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+ + + 11 + 3 + + 1864 + Mar + + + Hall's journal of health + Halls J Health + + Public Notice. + + 65-66 + + eng + + Journal Article + +
+ + United States + Halls J Health + 0011644 + +
+ + + + 1864 + 03 + 01 + + + 2022 + 12 + 9 + 12 + 28 + + + 1864 + 3 + 1 + 0 + 0 + + + 1864 + 3 + 1 + 0 + 0 + + + ppublish + + 36488189 + PMC9196372 + + +
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+ + + 11 + 3 + + 1864 + Mar + + + Hall's journal of health + Halls J Health + + Frenzy. + + 56-58 + + eng + + Journal Article + +
+ + United States + Halls J Health + 0011644 + +
+ + + + 1864 + 03 + 01 + + + 2022 + 12 + 9 + 12 + 28 + + + 1864 + 3 + 1 + 0 + 0 + + + 1864 + 3 + 1 + 0 + 0 + + + ppublish + + 36488187 + PMC9196370 + + +
+ + + 36488185 + + 2022 + 12 + 09 + +
+ + + 11 + 3 + + 1864 + Mar + + + Hall's journal of health + Halls J Health + + Parental Corrections. + + 47-56 + + eng + + Journal Article + +
+ + United States + Halls J Health + 0011644 + +
+ + + + 1864 + 03 + 01 + + + 2022 + 12 + 9 + 12 + 28 + + + 1864 + 3 + 1 + 0 + 0 + + + 1864 + 3 + 1 + 0 + 0 + + + ppublish + + 36488185 + PMC9196368 + + +
+ + + 36488175 + + 2022 + 12 + 09 + +
+ + + 11 + 9 + + 1864 + Sep + + + Hall's journal of health + Halls J Health + + Living beyond One's Means. + + 175-178 + + + + Bowen + H C + HC + + + eng + + Journal Article + +
+ + United States + Halls J Health + 0011644 + +
+ + + + 1864 + 09 + 01 + + + 2022 + 12 + 9 + 12 + 28 + + + 1864 + 9 + 1 + 0 + 0 + + + 1864 + 9 + 1 + 0 + 0 + + + ppublish + + 36488175 + PMC9196358 + + +
+ + + 36488184 + + 2022 + 12 + 09 + +
+ + + 11 + 3 + + 1864 + Mar + + + Hall's journal of health + Halls J Health + + Fidelity. + + 60-61 + + eng + + Journal Article + +
+ + United States + Halls J Health + 0011644 + +
+ + + + 1864 + 03 + 01 + + + 2022 + 12 + 9 + 12 + 28 + + + 1864 + 3 + 1 + 0 + 0 + + + 1864 + 3 + 1 + 0 + 0 + + + ppublish + + 36488184 + PMC9196367 + + +
+ + + 36488179 + + 2022 + 12 + 09 + +
+ + + 11 + 9 + + 1864 + Sep + + + Hall's journal of health + Halls J Health + + Health Tract, No. 213: Philosophy of Eating. + + 180 + + eng + + Journal Article + +
+ + United States + Halls J Health + 0011644 + +
+ + + + 1864 + 09 + 01 + + + 2022 + 12 + 9 + 12 + 28 + + + 1864 + 9 + 1 + 0 + 0 + + + 1864 + 9 + 1 + 0 + 0 + + + ppublish + + 36488179 + PMC9196362 + + +
+ + + 36488186 + + 2022 + 12 + 09 + +
+ + + 11 + 3 + + 1864 + Mar + + + Hall's journal of health + Halls J Health + + Health Tract, No. 201: Apoplexy. + + 67 + + eng + + Journal Article + +
+ + United States + Halls J Health + 0011644 + +
+ + + + 1864 + 03 + 01 + + + 2022 + 12 + 9 + 12 + 28 + + + 1864 + 3 + 1 + 0 + 0 + + + 1864 + 3 + 1 + 0 + 0 + + + ppublish + + 36488186 + PMC9196369 + + +
+ + + 36488192 + + 2022 + 12 + 09 + +
+ + + 11 + 8 + + 1864 + Aug + + + Hall's journal of health + Halls J Health + + Health Tract, No. 9: Uses of Ice. + + 165 + + eng + + Journal Article + +
+ + United States + Halls J Health + 0011644 + +
+ + + + 1864 + 08 + 01 + + + 2022 + 12 + 9 + 12 + 28 + + + 1864 + 8 + 1 + 0 + 0 + + + 1864 + 8 + 1 + 0 + 0 + + + ppublish + + 36488192 + PMC9196375 + + +
+ + + 36488188 + + 2022 + 12 + 09 + +
+ + + 11 + 3 + + 1864 + Mar + + + Hall's journal of health + Halls J Health + + How to Rise. + + 63-64 + + eng + + Journal Article + +
+ + United States + Halls J Health + 0011644 + +
+ + + + 1864 + 03 + 01 + + + 2022 + 12 + 9 + 12 + 28 + + + 1864 + 3 + 1 + 0 + 0 + + + 1864 + 3 + 1 + 0 + 0 + + + ppublish + + 36488188 + PMC9196371 + + +
+ + + 36488193 + + 2022 + 12 + 09 + +
+ + 1520-5126 + + + 2022 + Dec + 09 + + + Journal of the American Chemical Society + J Am Chem Soc + + DNA G-Quadruplex Recognition In Vitro and in Live Cells by a Structure-Specific Nanobody. + 10.1021/jacs.2c10656 + + G-quadruplexes (G4s) are four-stranded DNA secondary structures that occur in the human genome and play key roles in transcription, replication, and genome stability. G4-specific molecular probes are of vital importance to elucidate the structure and function of G4s. The scFv antibody BG4 has been a widely used G4 probe but has various limitations, including relatively poor in vitro expression and the inability to be expressed intracellularly to interrogate G4s in live cells. To address these considerations, we describe herein the development of SG4, a camelid heavy-chain-only derived nanobody that was selected against the human Myc DNA G4 structure. SG4 exhibits low nanomolar affinity for a wide range of folded G4 structures in vitro. We employed AlphaFold combined with molecular dynamics simulations to construct a molecular model for the G4-nanobody interaction. The structural model accurately explains the role of key amino acids and Kd measurements of SG4 mutants, including arginine-to-alanine point mutations that dramatically diminish G4 binding affinity. Importantly, predicted amino acid-G4 interactions were subsequently confirmed experimentally by biophysical measurements. We demonstrate that the nanobody can be expressed intracellularly and used to image endogenous G4 structures in live cells. We also use the SG4 protein to positionally map G4s in situ and also on fixed chromatin. SG4 is a valuable, new tool for G4 detection and mapping in cells. + + + + Galli + Silvia + S + 0000-0002-3316-0161 + + Cancer Research UK Cambridge Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, U.K. + + + Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K. + + + + Melidis + Larry + L + 0000-0001-6853-2722 + + Cancer Research UK Cambridge Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, U.K. + + + Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K. + + + + Flynn + Sean M + SM + 0000-0001-7326-2659 + + Cancer Research UK Cambridge Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, U.K. + + + + Varshney + Dhaval + D + 0000-0001-9197-9821 + + Cancer Research UK Cambridge Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, U.K. + + + + Simeone + Angela + A + 0000-0002-0663-0121 + + Cancer Research UK Cambridge Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, U.K. + + + + Spiegel + Jochen + J + 0000-0001-7641-1066 + + Cancer Research UK Cambridge Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, U.K. + + + Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K. + + + + Madden + Sarah K + SK + 0000-0001-6858-7651 + + Cancer Research UK Cambridge Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, U.K. + + + Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K. + + + + Tannahill + David + D + 0000-0002-3811-6864 + + Cancer Research UK Cambridge Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, U.K. + + + + Balasubramanian + Shankar + S + 0000-0002-0281-5815 + + Cancer Research UK Cambridge Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, U.K. + + + Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K. + + + School of Clinical Medicine, University of Cambridge, Cambridge CB2 0SP, U.K. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + J Am Chem Soc + 7503056 + 0002-7863 + + IM +
+ + + + 2022 + 12 + 9 + 12 + 32 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36488193 + 10.1021/jacs.2c10656 + + +
+ + + 36488190 + + 2022 + 12 + 09 + +
+ + + 11 + 3 + + 1864 + Mar + + + Hall's journal of health + Halls J Health + + Notices. + + 68 + + eng + + Journal Article + +
+ + United States + Halls J Health + 0011644 + +
+ + + + 1864 + 03 + 01 + + + 2022 + 12 + 9 + 12 + 28 + + + 1864 + 3 + 1 + 0 + 0 + + + 1864 + 3 + 1 + 0 + 0 + + + ppublish + + 36488190 + PMC9196373 + + +
+ + + 36488194 + + 2022 + 12 + 09 + +
+ + 1741-7899 + + + 2022 + Dec + 01 + + + Reproduction (Cambridge, England) + Reproduction + + Mouse uterine stem cells are affected by endocrine disruption and initiate uteropathies. + 10.1530/REP-22-0337 + REP-22-0337 + + Underlying pathomechanisms leading to initiation of uteropathies including non-receptive endometrium, hyperplasia, adenomyosis, endometriosis, fibroids, and cancer remain elusive. Two populations of stem cells exist in mouse uterus including pluripotent, very small embryonic-like stem cells (VSELs) and 'progenitors' endometrial stem cells (EnSCs) which express ERα, ERβ, PR and FSHR, participate in the regular remodelling and maintain life-long homeostasis. The present study aimed to delineate possible stem cell origins for various uteropathies. For this mouse pups were treated with estradiol or diethylstilbestrol and were studied for adult onset of various uteropathies. Treatment resulted in disrupted estrous cycles, reduced uterine weights, and marked hyperplasia in both epithelial and myometrial compartments, and the stromal compartment was also affected. VSELs were increased in numbers as judged by flow cytometry and increased expression of transcripts specific for Oct-4A, Sox-2, and Nanog but their further differentiation into a receptive endometrium was affected. Reduced 5-methyl cytosine expression suggested global hypomethylation and was associated with several oncogenic events including loss of tumor suppressor genes (Pten, p53), dysregulated DNA mismatch repair axis, and repair enzymes. Stem cells were epigenetically altered and showed increased expression of DNMTs, loss of imprinting loci (Igf2-H19, Dlk1-Meg3), and Ezh2. Increased co-expression of CD166 and ALDHA1 with OCT-4 in stem cells was associated with increased Esr-2 and reduced Pr in the endometrium while both were several folds upregulated in the myometrium. Study results suggest that various uteropathies ensue due to the dysfunction of tissue-resident stem cells and provide huge scope for further research. + + + + Singh + Pushpa + P + + P Singh, Stem Cell Biology Department, ICMR-National Institute for Research in Reproductive and Child Health, Mumbai, India. + + + + Bhartiya + Deepa + D + + D Bhartiya, Stem Cell Biology Department, ICMR-National Institute for Research in Reproductive and Child Health, Mumbai, India. + + + + eng + + Journal Article + + + 2022 + 12 + 01 + +
+ + England + Reproduction + 100966036 + 1470-1626 + + IM +
+ + + + 2022 + 07 + 08 + + + 2022 + 12 + 09 + + + 2022 + 12 + 9 + 12 + 32 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36488194 + 10.1530/REP-22-0337 + REP-22-0337 + + +
+ + + 36488195 + + 2022 + 12 + 09 + +
+ + 1741-7899 + + + 2022 + Dec + 01 + + + Reproduction (Cambridge, England) + Reproduction + + Placental leukocyte infiltration accompannies gestational changes induced by hyperthyroidism. + 10.1530/REP-22-0210 + REP-22-0210 + + Thyroid dysfunctions lead to metabolic, angiogenic, and developmental alterations at the maternal-fetal interface that cause reproductive complications. Thyroid hormones (THs) act through their nuclear receptors that interact with other steroid hormone receptors. Currently, immunological regulation by thyroid status has been characterized to a far less extent. It is well known that THs exert regulatory function on immune cells and modulate cytokine expression, but how hyperthyroidism (hyper) modulates placental immunological aspects leading to placental alterations is unknown. This work aims to throw light on how hyper modulates immunological and morphological placental aspects. Control and hyper (induced by a daily subcutaneous injection of T4 0,25 mg/kg) Wistar rats were mated eight days after starting T4 treatment, and euthanized on days 19 (G19) and 20 (G20) of pregnancy. We removed the placenta to perform qPCR, flow cytometry, immunohistochemistry, Western blot and histological analysis, and amniotic fluid and serum to evaluate hormone levels. We observed that hyper increases fetal number and weight, and placental weight on G19. Moreover, hyper induced an endocrine imbalance with higher serum corticosterone and changed placental morphology, specifically the basal zone and decidua. These changes were accompanied by an increased mRNA expression of GR and MCP-1, an increased mRNA and protein expression of PRL-R and an increase in CD45+ infiltration. Finally, by in vitro assays, we evidenced that TH induced immune cell activation. In summary, we demonstrated that hyper modulates immunological and morphological placental aspects and induces fetal phenotypic changes, which could be related to preterm labor observed in hyper. + + + + Sánchez + María Belén + MB + + M Sánchez, Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Mendoza, Argentina. + + + + Neira + Flavia Judith + FJ + + F Neira, Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), Consejo Nacional de Investigaciones Científicas y Técnicas, Mendoza, Argentina. + + + + Moreno-Sosa + Tamara + T + + T Moreno-Sosa, Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), Consejo Nacional de Investigaciones Científicas y Técnicas, Mendoza, Argentina. + + + + Michel Lara + María Cecilia + MC + + M Michel Lara, Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), Consejo Nacional de Investigaciones Científicas y Técnicas, Mendoza, Argentina. + + + + Viruel + Luciana Belén + LB + + L Viruel, Facultad de Ciencias Veterinarias y Ambientales, Universidad Juan Agustín Maza, Mendoza, Argentina. + + + + Germanó + María José + MJ + + M Germanó, Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Mendoza, Argentina. + + + + Pietrobon + Elisa Olivia + EO + + E Pietrobon, Instituto de Medicina y Biología Experimental de Cuyo, Centro Científico Tecnológico (CCT) - Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), República Argentina, Mendoza, Argentina. + + + + Troncoso + Mariana + M + + M Troncoso, Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Mendoza, Argentina. + + + + Soaje + Marta + M + + M Soaje, Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Mendoza, Argentina. + + + + Jahn + Graciela Alma + GA + + G Jahn, Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Mendoza, Argentina. + + + + Valdez + Susana Ruth + SR + + S Valdez, Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Mendoza, Argentina. + + + + Mackern-Oberti + Juan Pablo + JP + + J Mackern-Oberti, CONICET, IMBECU, Mendoza, Argentina. + + + + eng + + Journal Article + + + 2022 + 12 + 01 + +
+ + England + Reproduction + 100966036 + 1470-1626 + + IM +
+ + + + 2022 + 06 + 13 + + + 2022 + 12 + 09 + + + 2022 + 12 + 9 + 12 + 32 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36488195 + 10.1530/REP-22-0210 + REP-22-0210 + + +
+ + + 36488196 + + 2022 + 12 + 09 + +
+ + 1748-880X + + + 2022 + Dec + 09 + + + The British journal of radiology + Br J Radiol + + Breast MRI: an illustration of benign findings. + + 20220280 + + 10.1259/bjr.20220280 + + Despite its unparalleled sensitivity for aggressive breast cancer, breast MRI continually excites criticism for a specificity that lags behind that of modern mammographic techniques. Radiologists reporting breast MRI need to recognise the range of benign appearances on breast MRI to avoid unnecessary biopsy. This review summarises the reported diagnostic accuracy of breast MRI with particular attention to the technique's specificity, provides a referenced reporting strategy and discusses factors that compromise diagnostic confidence. We then present a pictorial review of benign findings on breast MRI. Enhancing radiological skills to discriminate malignant from benign findings will minimise false positive biopsies, enabling optimal use of multiparametric breast MRI for the benefit of screening clients and breast cancer patients. + + + + Jones + Lyn Isobel + LI + 0000-0001-7439-7037 + + Bristol Breast Care Centre, North Bristol NHS Trust, Bristol, United Kingdom. + + + + Klimczak + Katherine + K + + Bristol Breast Care Centre, North Bristol NHS Trust, Bristol, United Kingdom. + + + + Geach + Rebecca + R + + Bristol Breast Care Centre, North Bristol NHS Trust, Bristol, United Kingdom. + + + + eng + + Journal Article + Review + + + 2022 + 12 + 09 + +
+ + England + Br J Radiol + 0373125 + 0007-1285 + + IM +
+ + + + 2022 + 12 + 9 + 12 + 32 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36488196 + 10.1259/bjr.20220280 + + +
+ + + 36488197 + + 2022 + 12 + 09 + +
+ + 1466-187X + + + 2022 + Dec + 09 + + + Medical teacher + Med Teach + + Response to: 'Models of clinical integration into basic science education for first year medical students'. + + 1 + + 10.1080/0142159X.2022.2152666 + + + Cheung + Clement + C + + Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA, USA. + + + + eng + + Letter + + + 2022 + 12 + 09 + +
+ + England + Med Teach + 7909593 + 0142-159X + + IM +
+ + + + 2022 + 12 + 9 + 12 + 32 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36488197 + 10.1080/0142159X.2022.2152666 + + +
+ + + 36488198 + + 2022 + 12 + 09 + +
+ + 1466-187X + + + 2022 + Dec + 09 + + + Medical teacher + Med Teach + + The relationship of psychological health and primary emotional traits in medical students. + + 1-7 + + 10.1080/0142159X.2022.2152662 + + Several studies have called for attention to medical students' well-being. Building on the neuroevolutionary affective neuroscience perspective that views primary emotional systems as central to well-being and the foundation of personality, this study investigated the facets of medical students' psychological well-being that are challenged and the relationships between emotional traits, psychological well-being, and depression. + In a single-center cross-sectional study, medical students' primary emotional traits (SEEKING, FEAR, ANGER, SADNESS, CARE, PLAY and Spirituality), psychological well-being dimensions (autonomy, environmental mastery, positive relations, self-acceptance, purpose in life, and personal growth), and depressive symptoms were assessed using the Affective Neuroscience Personality Scale; the Psychological Well-being Scale, which provides normative data; and the Beck Depression Inventory. + Compared with the normative data, the medical students perceived lower psychological autonomy, positive relations, and self-acceptance but higher purpose in life. The medical students' emotional traits were related to specific psychological well-being facets and depression. SEEKING and, inversely, FEAR were related to well-being across dimensions and depressive symptoms. + Our findings are the first to show a link between emotional traits and specific facets of psychological health in medical students. Thus, this study encourages medical teachers to set learning environments that target multiple facets of well-being that harness primary emotional traits. + + + + Colonnello + Valentina + V + + Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy. + + + + Leonardi + Gloria + G + + Santa Viola Hospital, Colibrì Consortium, Bologna, Italy. + + + + Farinelli + Marina + M + + Clinical Psychology Service, Villa Bellombra Rehabilitation Hospital, Colibrì Consortium, Bologna, Italy. + + + + Russo + Paolo M + PM + + Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + England + Med Teach + 7909593 + 0142-159X + + IM + + Depression + affective neuroscience + emotions + individual differences + personality + well-being + +
+ + + + 2022 + 12 + 9 + 12 + 33 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36488198 + 10.1080/0142159X.2022.2152662 + + +
+ + + 36488201 + + 2022 + 12 + 09 + +
+ + + 11 + 8 + + 1864 + Aug + + + Hall's journal of health + Halls J Health + + Health Tract, No. 205: Cooking Meats. + + 164 + + eng + + Journal Article + +
+ + United States + Halls J Health + 0011644 + +
+ + + + 1864 + 08 + 01 + + + 2022 + 12 + 9 + 12 + 33 + + + 1864 + 8 + 1 + 0 + 0 + + + 1864 + 8 + 1 + 0 + 0 + + + ppublish + + 36488201 + PMC9196376 + + +
+ + + 36488199 + + 2022 + 12 + 09 + +
+ + 1931-7913 + + 22 + 1 + + 2023 + Mar + + + CBE life sciences education + CBE Life Sci Educ + + Exploring the Complementarity of Measures of Instructional Practices. + + ar1 + + 10.1187/cbe.22-03-0047 + + The assessment of instructional quality has been and continues to be a desirable, yet difficult endeavor in higher education. The development of new teaching evaluation frameworks along with instruments to measure various aspects of teaching practices holds promise. The challenge rests in the implementation of these frameworks and measures in authentic settings. Part of this challenge is for instructors, researchers, and administrators to parse through and select a meaningful set of tools from the plethora of existing instruments. In this study, we aim to start clarifying the landscape of measures of instructional practice by exploring the complementarity of two existing instruments: the Classroom Observation Protocol for Undergraduate STEM (COPUS) and the Learner-Centered Teaching Rubrics (LCTR). We collected classroom observations and course artifacts from 28 science instructors from research-intensive institutions across the United States. Results show the need to use both instruments to capture nuanced and comprehensive description of a faculty member's instructional practice. This study highlights the messiness of measuring instructional quality and the need to explore the implementation of teaching evaluation frameworks and measures of instructional practices in authentic settings. + + + + Shi + Lu + L + + Department of Chemistry, University of Virginia, Charlottesville, VA 22904. + + + + Popova + Maia + M + + Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC 27412. + + + + Erdmann + Robert M + RM + + Campus Learning Data and Technology, University of Minnesota Rochester, Rochester, MN 55904. + + + + Pellegrini + Anthony + A + + Applied Research Associates, Panama City, FL 32401. + + + + Johnson + Victoria + V + + Illinois College of Optometry, Chicago, IL 60616. + + + + Le + Binh + B + + ProScribe, Omaha, NE 68007. + + + + Popple + Trina + T + + Gretna High School, Gretna, NE 68028. + + + + Nelson + Zachary + Z + + Lincoln North Star High School, Lincoln, NE 68504. + + + + Gaston + Molly Undersander + MU + + Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588. + + + + Stains + Marilyne + M + + Department of Chemistry, University of Virginia, Charlottesville, VA 22904. + + + + eng + + Journal Article + +
+ + United States + CBE Life Sci Educ + 101269039 + 1931-7913 + + IM +
+ + + + 2022 + 12 + 9 + 12 + 33 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + ppublish + + 36488199 + 10.1187/cbe.22-03-0047 + + +
+ + + 36488219 + + 2022 + 12 + 09 + +
+ + + 11 + 2 + + 1864 + Feb + + + Hall's journal of health + Halls J Health + + Health Tract, No. 184: Kindness Rewarded. + + 36 + + eng + + Journal Article + +
+ + United States + Halls J Health + 0011644 + +
+ + + + 1864 + 02 + 01 + + + 2022 + 12 + 9 + 12 + 33 + + + 1864 + 2 + 1 + 0 + 0 + + + 1864 + 2 + 1 + 0 + 0 + + + ppublish + + 36488219 + PMC9196395 + + +
+ + + 36488218 + + 2022 + 12 + 09 + +
+ + + 11 + 2 + + 1864 + Feb + + + Hall's journal of health + Halls J Health + + Health Tract, No. 191: Curiosities of Eating. + + 45 + + eng + + Journal Article + +
+ + United States + Halls J Health + 0011644 + +
+ + + + 1864 + 02 + 01 + + + 2022 + 12 + 9 + 12 + 33 + + + 1864 + 2 + 1 + 0 + 0 + + + 1864 + 2 + 1 + 0 + 0 + + + ppublish + + 36488218 + PMC9196394 + + +
+ + + 36488212 + + 2022 + 12 + 09 + +
+ + + 11 + 11 + + 1864 + Nov + + + Hall's journal of health + Halls J Health + + Directions to Army-Surgeons on the Field of Battle. + + 218-222 + + eng + + Journal Article + +
+ + United States + Halls J Health + 0011644 + +
+ + + + 1864 + 11 + 01 + + + 2022 + 12 + 9 + 12 + 33 + + + 1864 + 11 + 1 + 0 + 0 + + + 1864 + 11 + 1 + 0 + 0 + + + ppublish + + 36488212 + PMC9196387 + + +
+ + + 36488208 + + 2022 + 12 + 09 + +
+ + + 11 + 8 + + 1864 + Aug + + + Hall's journal of health + Halls J Health + + A Strange People. + + 153-156 + + eng + + Journal Article + +
+ + United States + Halls J Health + 0011644 + +
+ + + + 1864 + 08 + 01 + + + 2022 + 12 + 9 + 12 + 33 + + + 1864 + 8 + 1 + 0 + 0 + + + 1864 + 8 + 1 + 0 + 0 + + + ppublish + + 36488208 + PMC9196383 + + +
+ + + 36488211 + + 2022 + 12 + 09 + +
+ + + 11 + 11 + + 1864 + Nov + + + Hall's journal of health + Halls J Health + + The Greatest Enemy. + + 216-217 + + eng + + Journal Article + +
+ + United States + Halls J Health + 0011644 + +
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+ + + 36488216 + + 2022 + 12 + 09 + +
+ + + 11 + 11 + + 1864 + Nov + + + Hall's journal of health + Halls J Health + + Health Tract, No. 153: Bilious Diarrhea. + + 231 + + eng + + Journal Article + +
+ + United States + Halls J Health + 0011644 + +
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+ + + 36488222 + + 2022 + 12 + 09 + +
+ + + 11 + 2 + + 1864 + Feb + + + Hall's journal of health + Halls J Health + + Health Tract, No. 183: The Sick School-Girl. + + 35 + + eng + + Journal Article + +
+ + United States + Halls J Health + 0011644 + +
+ + + + 1864 + 02 + 01 + + + 2022 + 12 + 9 + 12 + 33 + + + 1864 + 2 + 1 + 0 + 0 + + + 1864 + 2 + 1 + 0 + 0 + + + ppublish + + 36488222 + PMC9196398 + + +
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+ + + 11 + 2 + + 1864 + Feb + + + Hall's journal of health + Halls J Health + + Health Tract, No. 192: Mind and Body. + + 46 + + eng + + Journal Article + +
+ + United States + Halls J Health + 0011644 + +
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+ + 2633-8386 + + + 2022 + Dec + 01 + + + Reproduction & fertility + Reprod Fertil + + New perspectives on fertility in transwomen with regard to spermatogonial stem cells. + 10.1530/RAF-22-0022 + RAF-22-0022 + + Objective Germ cells of transwomen are affected by gender affirming hormone therapy (GAHT). Fertility will be lost after surgical intervention, thereby fertility preservation becomes an increasingly important topic. We investigated if the absolute number of spermatogonia in transwomen is comparable at the time of gender affirming surgery (GAS) to that in prepubertal boys. Methods We carried out a retrospective study of testicular tissues from 25 selected subjects, which had undergone a comparable sex hormone therapy regimen using cyproterone acetate (10 or 12.5 mg) and estrogens. As controls, testicular biopsies of 5 cisgender adult men (aged 35 - 48 years) and 5 pre-/pubertal boys (5 - 14 years) were included. Testicular tissues were immuno-histochemically stained for MAGE A4 positive cells, the most advanced germ cell type. The number of spermatogonia per area were assessed. Clinical values and serum hormone values for FSH, LH, testosterone, free testosterone, estradiol and prolactin were determined on the day of GAS for correlation analyses. Results Round spermatids were the most advanced germ cell type in 3 subjects, 5 had an arrest at spermatocyte stage while 17 showed a spermatogonial arrest. On average, testicular tissues of transwomen contained 25.15 spermatogonia/mm3, a number that was significantly reduced com-pared to the two control groups (P < 0.01, adult 80.65 spermatogonia/mm3, pre-/pubertal boys 78.55 sper-matogonia/mm3). Linear regression analysis revealed that testes with higher weight and high LH contained more spermatogonia. Conclusion Irrespective of treatment dose or duration spermatogenesis was impaired. Spermatogonial numbers were significantly reduced for transwomen compared to the control groups. + + + + Schneider + Florian Josef + FJ + + F Schneider, Department of Clinical Andrology, University Hospital Münster Centre of Reproductive Medicine and Andrology, Munster, Germany. + + + + Dabel + Jennifer + J + + J Dabel, Institute of Reproductive Medicine, University Hospital Münster Centre of Reproductive Medicine and Andrology, Munster, Germany. + + + + Wistuba + Joachim + J + + J Wistuba, Institute of Reproductive and Regenerative Medicine, Center of Reproductive Medicine and Andrology, University Hospital Münster Centre of Reproductive Medicine and Andrology, Munster, Germany. + + + + Kliesch + Sabine + S + + S Kliesch, Department of Clinical Andrology, University Hospital Münster Centre of Reproductive Medicine and Andrology, Munster, Germany. + + + + Schlatt + Stefan + S + + S Schlatt, CeRA, University Münster, Münster, 48149, Germany. + + + + Neuhaus + Nina + N + + N Neuhaus, Institute of Reproductive and Regenerative Medicine, University Hospital Münster Centre of Reproductive Medicine and Andrology, Munster, Germany. + + + + eng + + Journal Article + + + 2022 + 12 + 01 + +
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+ + 2194-802X + + + 2022 + Dec + 09 + + + Diagnosis (Berlin, Germany) + Diagnosis (Berl) + + Impact of diagnostic checklists on the interpretation of normal and abnormal electrocardiograms. + 10.1515/dx-2022-0092 + + Checklists that aim to support clinicians' diagnostic reasoning processes are often recommended to prevent diagnostic errors. Evidence on checklist effectiveness is mixed and seems to depend on checklist type, case difficulty, and participants' expertise. Existing studies primarily use abnormal cases, leaving it unclear how the diagnosis of normal cases is affected by checklist use. We investigated how content-specific and debiasing checklists impacted performance for normal and abnormal cases in electrocardiogram (ECG) diagnosis. + In this randomized experiment, 42 first year general practice residents interpreted normal, simple abnormal, and complex abnormal ECGs without a checklist. One week later, they were randomly assigned to diagnose the ECGs again with either a debiasing or content-specific checklist. We measured residents' diagnostic accuracy, confidence, patient management, and time taken to diagnose. Additionally, confidence-accuracy calibration was assessed. + Accuracy, confidence, and patient management were not significantly affected by checklist use. Time to diagnose decreased with a checklist (M=147s (77)) compared to without a checklist (M=189s (80), Z=-3.10, p=0.002). Additionally, residents' calibration improved when using a checklist (phase 1: R2=0.14, phase 2: R2=0.40). + In both normal and abnormal cases, checklist use improved confidence-accuracy calibration, though accuracy and confidence were not significantly affected. Time to diagnose was reduced. Future research should evaluate this effect in more experienced GPs. Checklists appear promising for reducing overconfidence without negatively impacting normal or simple ECGs. Reducing overconfidence has the potential to improve diagnostic performance in the long term. + © 2022 the author(s), published by De Gruyter, Berlin/Boston. + + + + Staal + Justine + J + + Erasmus Medical Center Rotterdam, Institute of Medical Education Research Rotterdam, Rotterdam, The Netherlands. + + + + Zegers + Robert + R + + Department of General Practice, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands. + + + + Caljouw-Vos + Jeanette + J + + General Practice Caljouw, Ridderkerk, The Netherlands. + + + + Mamede + Sílvia + S + https://orcid.org/0000-0003-1187-2392 + + Erasmus Medical Center Rotterdam, Institute of Medical Education Research Rotterdam, Rotterdam, The Netherlands. + + + Department of Psychology, Education and Child Studies, Erasmus School of Social and Behavioral Sciences, Rotterdam, The Netherlands. + + + + Zwaan + Laura + L + https://orcid.org/0000-0003-3940-1699 + + Erasmus Medical Center Rotterdam, Institute of Medical Education Research Rotterdam, Rotterdam, The Netherlands. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + Germany + Diagnosis (Berl) + 101654734 + 2194-802X + + IM + + ECG diagnosis + checklist + clinical reasoning + diagnostic error + general practice + +
+ + + + 2022 + 08 + 19 + + + 2022 + 11 + 27 + + + 2022 + 12 + 9 + 12 + 42 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36490202 + dx-2022-0092 + 10.1515/dx-2022-0092 + + + References + + Zia, SMR, Zahid, R, Ashraf, H. The WHO surgical safety checklist: a systematic literature review. Arch Surg Res 2021;2:27–30. + + + Thomassen, Ø, Storesund, A, Søfteland, E, Brattebø, G. The effects of safety checklists in medicine: a systematic review. Acta Anaesthesiol Scand 2014;58:5–18. https://doi.org/10.1111/aas.12207. + + + Woodward, HI, Mytton, OT, Lemer, C, Yardley, IE, Ellis, BM, Rutter, PD, et al.. What have we learned about interventions to reduce medical errors? Annu Rev Publ Health 2010;31:479–97. https://doi.org/10.1146/annurev.publhealth.012809.103544. + + + Pronovost, P, Needham, D, Berenholtz, S, Sinopoli, D, Chu, H, Cosgrove, S, et al.. An intervention to decrease catheter-related bloodstream infections in the ICU. 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+ + 1437-4315 + + + 2022 + Dec + 09 + + + Biological chemistry + Biol Chem + + Small-molecule metabolites in SARS-CoV-2 treatment: a comprehensive review. + 10.1515/hsz-2022-0323 + + The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has quickly spread all over the world. In this respect, traditional medicinal chemistry, repurposing, and computational approaches have been exploited to develop novel medicines for treating this condition. The effectiveness of chemicals and testing methods in the identification of new promising therapies, and the extent of preparedness for future pandemics, have been further highly advantaged by recent breakthroughs in introducing noble small compounds for clinical testing purposes. Currently, numerous studies are developing small-molecule (SM) therapeutic products for inhibiting SARS-CoV-2 infection and replication, as well as managing the disease-related outcomes. Transmembrane serine protease (TMPRSS2)-inhibiting medicinal products can thus prevent the entry of the SARS-CoV-2 into the cells, and constrain its spreading along with the morbidity and mortality due to the coronavirus disease 2019 (COVID-19), particularly when co-administered with inhibitors such as chloroquine (CQ) and dihydroorotate dehydrogenase (DHODH). The present review demonstrates that the clinical-stage therapeutic agents, targeting additional viral proteins, might improve the effectiveness of COVID-19 treatment if applied as an adjuvant therapy side-by-side with RNA-dependent RNA polymerase (RdRp) inhibitors. + © 2022 Walter de Gruyter GmbH, Berlin/Boston. + + + + Alipoor + Reza + R + https://orcid.org/0000-0003-2107-8192 + + Student Research Committee, Hormozgan University of Medical Sciences, Bandar Abbas, Iran. + + + + Ranjbar + Reza + R + https://orcid.org/0000-0001-8593-1514 + + Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran. + + + + eng + + Journal Article + Review + + + 2022 + 12 + 09 + +
+ + Germany + Biol Chem + 9700112 + 1431-6730 + + IM + + SARS-CoV-2 + anti-infectives + molecular mechanism + small-molecule metabolite + therapy + +
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+ + 1651-2014 + + + 2022 + Dec + 09 + + + Scandinavian journal of occupational therapy + Scand J Occup Ther + + Establishing the measurement properties of the Residential Environment Impact Scale (Version 4.0). + + 1-10 + + 10.1080/11038128.2022.2143891 + + Developed as an environment assessment informed by the Model of Human Occupation, the Residential Environment Impact Survey considered the physical, social and activity features of the environment, evaluating the impact of the environment on resident's quality of life. Clinicians reported that the Residential Environment Impact Survey was a useful tool; however, it had not been structured to be a measurement tool and did not have established psychometric properties. + This study examines the psychometric properties of the restructured Residential Environment Impact Scale Version 4.0 (REIS), which measures the level of environment support provided to residents. + The REIS was completed across residential sites for people with complex mental health needs. A many facets Rasch analysis was conducted to establish the reliability and validity of the REIS. + The REIS demonstrated reasonable psychometric properties, with items demonstrating internal scale validity and scale items following an expected pattern of increasingly challenging environment support. + Initial evidence suggests that the REIS provides a valid and reliable measure of environment support, providing a detailed assessment of how physical, social and activity elements of the environment support or inhibit participation and can be applied across a range of living environments. + + + + Harrison + Michele + M + 0000-0001-6088-2998 + + School of Health Sciences, Queen Margaret University, Edinburgh, Scotland. + + + + Forsyth + Kirsty + K + 0000-0002-6732-1699 + + School of Health Sciences, Queen Margaret University, Edinburgh, Scotland. + + + + Murray + Aja Louise + AL + + School of Health Sciences, Queen Margaret University, Edinburgh, Scotland. + + + School of Philosophy, Psychology and Language Sciences, University of Edinburgh, Edinburgh, Scotland. + + + + Angarola + Rocco + R + + School of Health Sciences, Queen Margaret University, Edinburgh, Scotland. + + + Midlothian Health and Social Care Partnership, Dalkeith, Scotland. + + + + Henderson + Shona + S + + School of Health Sciences, Queen Margaret University, Edinburgh, Scotland. + + + + Irvine Fitzpatrick + Linda + L + 0000-0002-9599-8015 + + Thrive Edinburgh, Edinburgh Health and Social Care Partnership, Edinburgh, Scotland. + + + + Fisher + Gail + G + 0000-0002-6839-8532 + + Department of Occupational Therapy, University of Illinois Chicago, Chicago, IL, USA. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + England + Scand J Occup Ther + 9502210 + 1103-8128 + + IM + + Activities of daily living + environment + mental health + occupational therapy + participation + +
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+ + 1527-1323 + + 43 + 1 + + 2023 + Jan + + + Radiographics : a review publication of the Radiological Society of North America, Inc + Radiographics + + Focal Nodular Hyperplasia-like Lesions in Patients with Extrahepatic Portal Vein Obstruction. + + e220164 + + 10.1148/rg.220164 + + + Madhusudhan + Kumble Seetharama + KS + 0000-0001-8806-2625 + + Department of Radiodiagnosis and Interventional Radiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India. + + + + eng + + Letter + +
+ + United States + Radiographics + 8302501 + 0271-5333 + + IM +
+ + + + 2022 + 12 + 9 + 12 + 52 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + ppublish + + 36490209 + 10.1148/rg.220164 + + +
+ + + 36490211 + + 2022 + 12 + 09 + +
+ + 1527-1323 + + 43 + 1 + + 2023 + Jan + + + Radiographics : a review publication of the Radiological Society of North America, Inc + Radiographics + + Deadly Fungi: Invasive Fungal Rhinosinusitis in the Head and Neck. + + e229015 + + 10.1148/rg.229015 + + + Kurokawa + Mariko + M + + + Kurokawa + Ryo + R + + + Baba + Akira + A + + + Kim + John + J + + + Tournade + Christopher + C + + + Mchugh + Jonathan + J + + + Trobe + Jonathan D + JD + + + Srinivasan + Ashok + A + + + Bapuraj + Jayapalli Rajiv + JR + + + Moritani + Toshio + T + + + eng + + Published Erratum + +
+ + United States + Radiographics + 8302501 + 0271-5333 + + IM + + + Radiographics. 2022 Nov-Dec;42(7):2075-2094 + 36178803 + + +
+ + + + 2022 + 12 + 9 + 12 + 52 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + ppublish + + 36490211 + 10.1148/rg.229015 + + +
+ + + 36490218 + + 2022 + 12 + 09 + +
+ + 1520-5827 + + + 2022 + Dec + 09 + + + Langmuir : the ACS journal of surfaces and colloids + Langmuir + + Jute-Fiber Precursor-Derived Low-Cost Sustainable Hard Carbon with Varying Micro/Mesoporosity and Distinct Storage Mechanisms for Sodium-Ion and Potassium-Ion Batteries. + 10.1021/acs.langmuir.2c02575 + + Hard carbon (HC) remains the most viable choice as a negative electrode for sodium-ion batteries (SIBs) and potassium-ion batteries (PIBs) owing to its higher energy density (discharge up to zero volts), higher capacity (distinct storage mechanisms), and cycling stability. Herein, a biomass jute fiber precursor HC anode (JPC) with varying porosity is reported for the first time as a low-cost and sustainable high-performance HC anode for SIBs and PIBs. Direct carbonization results in micro-meso porous HC (JPC-D), and micro-wave pretreated jute fiber results in ultramicroporous HC (JPC-M). The mesoporosity generated in JPC-D during synthesis outperforms the ultramicroporous JPC-M with a high reversible capacity of 328 mAh g-1 (iCE = 66%) at a current density of 30 mA g-1 (0.1C) with superior capacity retention of 84% after 100 cycles in SIBs. The Na+ ion and K+ ion storage in HCs, especially at lower voltages, shows distinct storage mechanisms that depend on the morphology and porosity of the material. JPC-D contributed 39% of its total capacity through the plateau region capacity (PRC), suggesting more pore filling from hierarchical porosity in SIBs. JPC-D and JPC-M exhibit more insertion-based capacity than pore-filling processes in PIBs. The presence of inorganic impurities (Ca, Si, Al, and Fe) encapsulated in the carbon structure plays a critical role in developing mesopores. The yield (%) of HC from direct carbonization per kilogram of jute is ∼34%, which makes it cheaper than HC from sugar-based precursors and 1.5 times more affordable than other biomass-derived HC. The jute-based micro-mesoporous HC is a novel, cost-effective, sustainable approach to designing HC for a PRC-based battery-type anode in SIBs and PIBs. + + + + Nagmani + 0000-0003-4618-4952 + + School of Energy Science & Engineering, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal 721302, India. + + + + Verma + Prakhar + P + + School of Energy Science & Engineering, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal 721302, India. + + + + Puravankara + Sreeraj + S + 0000-0002-9238-0148 + + School of Energy Science & Engineering, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal 721302, India. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + Langmuir + 9882736 + 0743-7463 + + IM +
+ + + + 2022 + 12 + 9 + 13 + 2 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36490218 + 10.1021/acs.langmuir.2c02575 + + +
+ + + 36490208 + + 2022 + 12 + 09 + +
+ + 1527-1323 + + 43 + 1 + + 2023 + Jan + + + Radiographics : a review publication of the Radiological Society of North America, Inc + Radiographics + + Cardiac Nuclear Medicine: Techniques, Applications, and Imaging Findings. + + e220027 + + 10.1148/rg.220027 + + + Panda + Ananya + A + 0000-0003-0862-0741 + + From the Department of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN 559905 (A.P., A.C.H., P.S.R.); Department of Radiology, All India Institute of Medical Sciences, Jodhpur, India (A.P); Department of Radiology, University of Tubingen, Tubingen, Germany (P.K., K.N.); and Department of Radiology, Cleveland Clinic Foundation, Cleveland, Ohio (S.S.H., W.J., M.A.B.). + + + + Homb + Andrew C + AC + + From the Department of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN 559905 (A.P., A.C.H., P.S.R.); Department of Radiology, All India Institute of Medical Sciences, Jodhpur, India (A.P); Department of Radiology, University of Tubingen, Tubingen, Germany (P.K., K.N.); and Department of Radiology, Cleveland Clinic Foundation, Cleveland, Ohio (S.S.H., W.J., M.A.B.). + + + + Krumm + Patrick + P + 0000-0003-1705-8439 + + From the Department of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN 559905 (A.P., A.C.H., P.S.R.); Department of Radiology, All India Institute of Medical Sciences, Jodhpur, India (A.P); Department of Radiology, University of Tubingen, Tubingen, Germany (P.K., K.N.); and Department of Radiology, Cleveland Clinic Foundation, Cleveland, Ohio (S.S.H., W.J., M.A.B.). + + + + Nikolaou + Konstantin + K + 0000-0003-2668-7325 + + From the Department of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN 559905 (A.P., A.C.H., P.S.R.); Department of Radiology, All India Institute of Medical Sciences, Jodhpur, India (A.P); Department of Radiology, University of Tubingen, Tubingen, Germany (P.K., K.N.); and Department of Radiology, Cleveland Clinic Foundation, Cleveland, Ohio (S.S.H., W.J., M.A.B.). + + + + Huang + Steve S + SS + 0000-0002-8260-737X + + From the Department of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN 559905 (A.P., A.C.H., P.S.R.); Department of Radiology, All India Institute of Medical Sciences, Jodhpur, India (A.P); Department of Radiology, University of Tubingen, Tubingen, Germany (P.K., K.N.); and Department of Radiology, Cleveland Clinic Foundation, Cleveland, Ohio (S.S.H., W.J., M.A.B.). + + + + Jaber + Wael + W + + From the Department of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN 559905 (A.P., A.C.H., P.S.R.); Department of Radiology, All India Institute of Medical Sciences, Jodhpur, India (A.P); Department of Radiology, University of Tubingen, Tubingen, Germany (P.K., K.N.); and Department of Radiology, Cleveland Clinic Foundation, Cleveland, Ohio (S.S.H., W.J., M.A.B.). + + + + Bolen + Michael A + MA + 0000-0002-0403-8343 + + From the Department of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN 559905 (A.P., A.C.H., P.S.R.); Department of Radiology, All India Institute of Medical Sciences, Jodhpur, India (A.P); Department of Radiology, University of Tubingen, Tubingen, Germany (P.K., K.N.); and Department of Radiology, Cleveland Clinic Foundation, Cleveland, Ohio (S.S.H., W.J., M.A.B.). + + + + Rajiah + Prabhakar Shantha + PS + 0000-0001-7538-385X + + From the Department of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN 559905 (A.P., A.C.H., P.S.R.); Department of Radiology, All India Institute of Medical Sciences, Jodhpur, India (A.P); Department of Radiology, University of Tubingen, Tubingen, Germany (P.K., K.N.); and Department of Radiology, Cleveland Clinic Foundation, Cleveland, Ohio (S.S.H., W.J., M.A.B.). + + + + eng + + Journal Article + +
+ + United States + Radiographics + 8302501 + 0271-5333 + + IM +
+ + + + 2022 + 12 + 9 + 12 + 52 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + ppublish + + 36490208 + 10.1148/rg.220027 + + +
+ + + 36490205 + + 2022 + 12 + 09 + +
+ + 1521-186X + + + 2022 + Dec + 09 + + + Bioelectromagnetics + Bioelectromagnetics + + Exposure to 10 Hz Pulsed Magnetic Field Induced Slight Apoptosis and Reactive Oxygen Species in Primary Human Gingival Fibroblasts. + 10.1002/bem.22428 + + Extremely low frequency pulsed magnetic fields (MFs) have been increasingly used as an effective method in oral therapy, but its potential impact on health has not been clarified. In this study, we investigated the impact of 10 Hz pulsed MF exposure on primary human gingival fibroblasts (HGFs) derived from eight healthy persons (four males and four females). Cells were exposed to 10 Hz pulsed MFs at 1.0 mT for 24 h. Cell apoptosis, cell cycle progression, intracellular reactive oxygen species levels, DNA damage, and cell proliferation were determined after exposure. The results showed that 10 Hz pulsed MFs exposure have slight effects on cellular apoptosis, cell cycle progression, and DNA damage in primary HGFs from some but not all samples. In addition, no significant effect was found on cell proliferation. © 2022 Bioelectromagnetics Society. + © 2022 Bioelectromagnetics Society. + + + + Huang + Zheng + Z + http://orcid.org/0000-0002-2778-0057 + + Stomatology Center, Affiliated Hospital of Hangzhou Normal University, Hangzhou, China. + + + School of Stomatology, Hangzhou Normal University, Hangzhou, China. + + + + Ding + Cheng + C + + Stomatology Center, Affiliated Hospital of Hangzhou Normal University, Hangzhou, China. + + + + Huang + Xinzhao + X + + Stomatology Center, Affiliated Hospital of Hangzhou Normal University, Hangzhou, China. + + + School of Stomatology, Hangzhou Normal University, Hangzhou, China. + + + + Sun + Chuan + C + http://orcid.org/0000-0003-3495-5641 + + Zhejiang Provincial Key Lab of Geriatrics & Geriatrics Institute of Zhejiang Province, Department of Geriatrics, Zhejiang Hospital, Hangzhou, China. + + + + Zhong + Liangjun + L + + Stomatology Center, Affiliated Hospital of Hangzhou Normal University, Hangzhou, China. + + + School of Stomatology, Hangzhou Normal University, Hangzhou, China. + + + + eng + + + 2021KY005 + Medical Science and Technology Project of Zhejiang Province + + + + 31700734 + National Science Foundation of China + + + + OO20200387 + Key medical disciplines of Hangzhou + + + + 20211231Y028 + Health and Science Project of Hangzhou + + + + A20210056 + Health and Science Project of Hangzhou + + + + 20211231Y028 + Guided Project of Science and Technology of Hangzhou + + + + 2021WJCY131 + Hangzhou Biological Medicine and Health Industry Development Support Science and Technology Progect + + + + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + Bioelectromagnetics + 8008281 + 0197-8462 + + IM + + DNA damage + apoptosis + gingival fibroblasts + pulsed electromagnetic fields + reactive oxygen species + +
+ + + + 2022 + 10 + 04 + + + 2022 + 03 + 04 + + + 2022 + 11 + 09 + + + 2022 + 12 + 9 + 12 + 42 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36490205 + 10.1002/bem.22428 + + + REFERENCES + + Abdelrahim A, Hassanein HR, Dahaba M. 2011. Effect of pulsed electromagnetic field on healing of mandibular fracture: A preliminary clinical study. J Oral Maxillofac Surg 69:1708-1717. + + + Acikgoz B, Ersoy N, Aksu I, Kiray A, Bagriyanik HA, Kiray M. 2022. Gender differences in effects of prenatal and postnatal exposure to electromagnetic field and prenatal zinc on behaviour and synaptic proteins in rats. J Chem Neuroanat 122:102092. + + + Bagheri Hosseinabadi M, Khanjani N, Mirzaii M, Norouzi P, Atashi A. 2019. DNA damage from long-term occupational exposure to extremely low-frequency electromagnetic fields among power plant workers. Mutat Res Genet Toxicol Environ Mutagen 846:403079. + + + Baranowska A, Skowron B, Gil K, Kaszuba-Zwoińska J. 2018. Effect of the pulsed electromagnetic field on the release of inflammatory mediators from adipose-derived stem cells (adscs) in rats. Folia Med Crac 58:21-34. + + + Bartold PM, Walsh LJ, Narayanan AS. 2000. Molecular and cell biology of the gingiva. Periodontology 2000 24:28-55. + + + Boonstra J, Post JA. 2004. Molecular events associated with reactive oxygen species and cell cycle progression in mammalian cells. Gene 337:1-13. + + + Brisdelli F, Bennato F, Bozzi A, Cinque B, Mancini F, Iorio R. 2014. Elf-mf attenuates quercetin-induced apoptosis in k562 cells through modulating the expression of bcl-2 family proteins. Mol Cell Biochem 397:33-43. + + + Chao HX, Poovey CE, Privette AA, Grant GD, Chao HY, Cook JG, Purvis JE. 2017. Orchestration of DNA damage checkpoint dynamics across the human cell cycle. Cell Syst 5:445-459. + + + Chiquet M, Katsaros C, Kletsas D. 2015. Multiple functions of gingival and mucoperiosteal fibroblasts in oral wound healing and repair. Periodontology 2000 68:21-40. + + + Cios A, Ciepielak M, Stankiewicz W, Szymański Ł. 2021. The influence of the extremely low frequency electromagnetic field on clear cell renal carcinoma. Int J Mol Sci 22:1342. + + + Costantini E, Sinjari B, D'Angelo C, Murmura G, Reale M, Caputi S. 2019. Human gingival fibroblasts exposed to extremely low-frequency electromagnetic fields: In vitro model of wound-healing improvement. Int J Mol Sci20:2108. + + + Di Loreto S, Falone S, Caracciolo V, Sebastiani P, D'Alessandro A, Mirabilio A, Zimmitti V, Amicarelli F. 2009. Fifty hertz extremely low-frequency magnetic field exposure elicits redox and trophic response in rat-cortical neurons. J Cell Physiol 219:334-343. + + + Engeland K. 2022. Cell cycle regulation: P53-p21-rb signaling. Cell Death Differ 29:946-960. + + + Focke F, Schuermann D, Kuster N, Schär P. 2010. DNA fragmentation in human fibroblasts under extremely low frequency electromagnetic field exposure. Mutat Res/Fundam Mol Mech Mutagen 683:74-83. + + + Hanlon CA, McCalley DM. 2022. Sex/gender as a factor that influences transcranial magnetic stimulation treatment outcome: Three potential biological explanations. Frontiers in psychiatry 13:869070. + + + Kim HS, Park BJ, Jang HJ, Ipper NS, Kim SH, Kim YJ, Jeon SH, Lee KS, Lee SK, Kim N, Ju YJ, Gimm YM, Kim YW. 2014. Continuous exposure to 60 Hz magnetic fields induces duration- and dose-dependent apoptosis of testicular germ cells. Bioelectromagnetics 35:100-107. + + + Lai H. 2021. Genetic effects of non-ionizing electromagnetic fields. Electromagn Biol Med 40:264-273. + + + Lee SK, Park S, Gimm YM, Kim YW. 2014. Extremely low-frequency magnetic fields induce spermatogenic germ cell apoptosis: Possible mechanism. BioMed Res Int 2014:567183. + + + Lekovic MH, Drekovic NE, Granica ND, Mahmutovic EH, Djordjevic NZ. 2020. Extremely low-frequency electromagnetic field induces a change in proliferative capacity and redox homeostasis of human lung fibroblast cell line mrc-5. Environ Sci Pollut Res 27:39466-39473. + + + Liu X, Wang J, Dong F, Li H, Hou Y. 2016. Human gingival fibroblasts induced and differentiated into vascular endothelial-like cells. Dev Growth Differ 58:702-713. + + + Lv Y, Chen S, Zhu B, Xu H, Xu S, Liu W, Shen Y, Zeng Q. 2021. Exposure to 50 hz extremely-low-frequency magnetic fields induces no DNA damage in cells by gamma h2ax technology. BioMed Res Int2021:8510315. + + + Matthews HK, Bertoli C, de Bruin RAM. 2022. Cell cycle control in cancer. Nat Rev Mol Cell Biol 23:74-88. + + + Mohajerani H, Tabeie F, Vossoughi F, Jafari E, Assadi M. 2019. Effect of pulsed electromagnetic field on mandibular fracture healing: A randomized control trial, (rct). J Stomatol Oral Maxillof Surg 120:390-396. + + + Nagashima Y, Kagaya H, Toda F, Aoyagi Y, Shibata S, Saitoh E, Abe K, Nakayama E, Ueda K. 2021. Effect of electromyography-triggered peripheral magnetic stimulation on voluntary swallow in healthy humans. J Oral Rehabil48:1354-1362. + + + Naskar S, Chandan I, Baskaran D, Roy Choudhury AN, Chatterjee S, Karunakaran S, Murthy BVS, Basu B. 2021. Dosimetry of pulsed magnetic field towards attaining bacteriostatic effect on Enterococcus faecalis: Implications for endodontic therapy. Int Endod J 54:1878-1891. + + + Nayak BP, Dolkart O, Satwalekar P, Kumar YP, Chandrasekar A, Fromovich O, Yakobson E, Barak S, Dayube U, Shibli JA. 2020. Effect of the pulsed electromagnetic field (pemf) on dental implants stability: A randomized controlled clinical trial. Materials 13:1667. + + + Nie Y, Du L, Mou Y, Xu Z, Weng L, Du Y, Zhu Y, Hou Y, Wang T. 2013. Effect of low frequency magnetic fields on melanoma: Tumor inhibition and immune modulation. BMC Cancer 13:582. + + + Nunes CMM, Ferreira CL, Bernardo DV, Lopes CCR, Collino L, da Silva Lima VC, de Camargo Reis Mello D, de Vasconcellos LMR, Jardini MAN. 2021. Evaluation of pulsed electromagnetic field protocols in implant osseointegration: In vivo and in vitro study. Clin Oral Investig 25:2925-2937. + + + Obeng E. 2021. Apoptosis (programmed cell death) and its signals-A review. Braz J Biol 81:1133-1143. + + + Palmer RM, Wilson RF, Hasan AS, Scott DA. 2005. Mechanisms of action of environmental factors-Tobacco smoking. J Clin Periodontol 32(Suppl 6):180-195. + + + Panagopoulos A, Altmeyer M. 2021. The hammer and the dance of cell cycle control. Trends Biochem Sci46:301-314. + + + Saliev T, Begimbetova D, Masoud AR, Matkarimov B. 2019. Biological effects of non-ionizing electromagnetic fields: Two sides of a coin. Progr Biophys Mol Biol141:25-36. + + + Schuermann D, Mevissen M. 2021. Manmade electromagnetic fields and oxidative stress-biological effects and consequences for health. Int J Mol Sci22:3773. + + + Serpico AF, Grieco D. 2020. Recent advances in understanding the role of cdk1 in the spindle assembly checkpoint. F1000Res 9:1057. + + + Shen JF, Du L, Chao YL, Xu C. 2007. [Effects of static magnetic field on the activity of superoxide dismutase of human gingival fibroblasts]. Sichuan da xue xue bao. Yi xue ban = J Sichuan Univer Med Sci Ed 38:276-278. + + + Showkatbakhsh R, Jamilian A, Showkatbakhsh M. 2010. The effect of pulsed electromagnetic fields on the acceleration of tooth movement. World J Orthod 11:52-56. + + + Sun C, Huang Z, Qin H, Zhang J, Wang S, Xu X, Ying S, Mao G. 2021. Exposure to 10 Hz pulsed magnetic fields do not induce cellular senescence in human fetal lung fibroblasts. Front Public Health 9:761069. + + + Uzbekov R, Prigent C. 2022. A journey through time on the discovery of cell cycle regulation. Cells 11:11. + + + Vallejo D, Hidalgo MA. 2012. Growth variations in OF1 mice following chronic exposure of parental and filial generations to a 15 μT, 50 Hz magnetic field. Electromagn Biol Med 31:19-33. + + + Verbon EH, Post JA, Boonstra J. 2012. The influence of reactive oxygen species on cell cycle progression in mammalian cells. Gene 511:1-6. + + + Wolf FI, Torsello A, Tedesco B, Fasanella S, Boninsegna A, D'Ascenzo M, Grassi C, Azzena GB, Cittadini A. 2005. 50-Hz extremely low-frequency electromagnetic fields enhance cell proliferation and DNA damage: Possible involvement of a redox mechanism. Biochim Biophys Acta 1743:120-129. + + + Yagci F, Kesim B. 2016. Cytotoxic and genotoxic effects on gingival fibroblasts from static magnetic fields produced by dental magnetic attachments. Gerodontology 33:421-427. + + + Yamaguchi H, Hosokawa K, Soda A, Miyamoto H, Kinouchi Y. 1993. Effects of seven months' exposure to a static 0.2 t magnetic field on growth and glycolytic activity of human gingival fibroblasts. Biochim Biophys Acta 1156:302-306. + + + Yang ML, Ye ZM. 2015. [extremely low frequency electromagnetic field induces apoptosis of osteosarcoma cells via oxidative stress]. Zhejiang da xue xue bao. Yi xue ban = J Zhejiang Unive Med Sci44:323-328. + + + Yuan LQ, Wang C, Lu DF, Zhao XD, Tan LH, Chen X. 2020. Induction of apoptosis and ferroptosis by a tumor suppressing magnetic field through ros-mediated DNA damage. Aging 12:3662-3681. + + + +
+ + + 36490210 + + 2022 + 12 + 09 + +
+ + 1527-1323 + + 43 + 1 + + 2023 + Jan + + + Radiographics : a review publication of the Radiological Society of North America, Inc + Radiographics + + Urinary Bladder Masses, Rare Subtypes, and Masslike Lesions: Radiologic-Pathologic Correlation. + + e220034 + + 10.1148/rg.220034 + + Urinary bladder masses are commonly encountered in clinical practice, with 95% arising from the epithelial layer and rarer tumors arising from the lamina propria, muscularis propria, serosa, and adventitia. The extent of neoplastic invasion into these bladder layers is assessed with multimodality imaging, and the MRI-based Vesical Imaging Reporting and Data System is increasingly used to aid tumor staging. Given the multiple layers and cell lineages, a diverse array of pathologic entities can arise from the urinary bladder, and distinguishing among benign, malignant, and nonneoplastic entities is not reliably feasible in most cases. Pathologic assessment remains the standard of care for classification of bladder masses. Although urothelial carcinoma accounts for most urinary bladder malignancies in the United States, several histopathologic entities exist, including squamous cell carcinoma, adenocarcinoma, melanoma, and neuroendocrine tumors. Furthermore, there are variant histopathologic subtypes of urothelial carcinoma (eg, the plasmacytoid variant), which are often aggressive. Atypical benign bladder masses are diverse and can have inflammatory or iatrogenic causes and mimic malignancy. © RSNA, 2022 Online supplemental material is available for this article. + + + + Hoegger + Mark J + MJ + 0000-0002-8214-8177 + + From the Mallinckrodt Institute of Radiology (M.J.H., B.S.S., D.H.B., C.L.S., A.S.S., V.M.M.) and Department of Pathology (R.C.W.), Washington University School of Medicine, Campus Box 8131, 510 Kingshighway Blvd, St Louis, MO 63110; and Department of Radiology (M.Y., A.K., M.Z.) and Department of Laboratory Medicine and Pathology (M.L.S.), Mayo Clinic Arizona, Scottsdale, Ariz. + + + + Strnad + Benjamin S + BS + 0000-0003-2308-1299 + + From the Mallinckrodt Institute of Radiology (M.J.H., B.S.S., D.H.B., C.L.S., A.S.S., V.M.M.) and Department of Pathology (R.C.W.), Washington University School of Medicine, Campus Box 8131, 510 Kingshighway Blvd, St Louis, MO 63110; and Department of Radiology (M.Y., A.K., M.Z.) and Department of Laboratory Medicine and Pathology (M.L.S.), Mayo Clinic Arizona, Scottsdale, Ariz. + + + + Ballard + David H + DH + 0000-0001-7470-3364 + + From the Mallinckrodt Institute of Radiology (M.J.H., B.S.S., D.H.B., C.L.S., A.S.S., V.M.M.) and Department of Pathology (R.C.W.), Washington University School of Medicine, Campus Box 8131, 510 Kingshighway Blvd, St Louis, MO 63110; and Department of Radiology (M.Y., A.K., M.Z.) and Department of Laboratory Medicine and Pathology (M.L.S.), Mayo Clinic Arizona, Scottsdale, Ariz. + + + + Siegel + Cary L + CL + 0000-0001-6581-3617 + + From the Mallinckrodt Institute of Radiology (M.J.H., B.S.S., D.H.B., C.L.S., A.S.S., V.M.M.) and Department of Pathology (R.C.W.), Washington University School of Medicine, Campus Box 8131, 510 Kingshighway Blvd, St Louis, MO 63110; and Department of Radiology (M.Y., A.K., M.Z.) and Department of Laboratory Medicine and Pathology (M.L.S.), Mayo Clinic Arizona, Scottsdale, Ariz. + + + + Shetty + Anup S + AS + 0000-0003-0333-9221 + + From the Mallinckrodt Institute of Radiology (M.J.H., B.S.S., D.H.B., C.L.S., A.S.S., V.M.M.) and Department of Pathology (R.C.W.), Washington University School of Medicine, Campus Box 8131, 510 Kingshighway Blvd, St Louis, MO 63110; and Department of Radiology (M.Y., A.K., M.Z.) and Department of Laboratory Medicine and Pathology (M.L.S.), Mayo Clinic Arizona, Scottsdale, Ariz. + + + + Weimholt + R Cody + RC + + From the Mallinckrodt Institute of Radiology (M.J.H., B.S.S., D.H.B., C.L.S., A.S.S., V.M.M.) and Department of Pathology (R.C.W.), Washington University School of Medicine, Campus Box 8131, 510 Kingshighway Blvd, St Louis, MO 63110; and Department of Radiology (M.Y., A.K., M.Z.) and Department of Laboratory Medicine and Pathology (M.L.S.), Mayo Clinic Arizona, Scottsdale, Ariz. + + + + Yano + Motoyo + M + + From the Mallinckrodt Institute of Radiology (M.J.H., B.S.S., D.H.B., C.L.S., A.S.S., V.M.M.) and Department of Pathology (R.C.W.), Washington University School of Medicine, Campus Box 8131, 510 Kingshighway Blvd, St Louis, MO 63110; and Department of Radiology (M.Y., A.K., M.Z.) and Department of Laboratory Medicine and Pathology (M.L.S.), Mayo Clinic Arizona, Scottsdale, Ariz. + + + + Stanton + Melissa L + ML + + From the Mallinckrodt Institute of Radiology (M.J.H., B.S.S., D.H.B., C.L.S., A.S.S., V.M.M.) and Department of Pathology (R.C.W.), Washington University School of Medicine, Campus Box 8131, 510 Kingshighway Blvd, St Louis, MO 63110; and Department of Radiology (M.Y., A.K., M.Z.) and Department of Laboratory Medicine and Pathology (M.L.S.), Mayo Clinic Arizona, Scottsdale, Ariz. + + + + Mellnick + Vincent M + VM + 0000-0003-4241-890X + + From the Mallinckrodt Institute of Radiology (M.J.H., B.S.S., D.H.B., C.L.S., A.S.S., V.M.M.) and Department of Pathology (R.C.W.), Washington University School of Medicine, Campus Box 8131, 510 Kingshighway Blvd, St Louis, MO 63110; and Department of Radiology (M.Y., A.K., M.Z.) and Department of Laboratory Medicine and Pathology (M.L.S.), Mayo Clinic Arizona, Scottsdale, Ariz. + + + + Kawashima + Akira + A + + From the Mallinckrodt Institute of Radiology (M.J.H., B.S.S., D.H.B., C.L.S., A.S.S., V.M.M.) and Department of Pathology (R.C.W.), Washington University School of Medicine, Campus Box 8131, 510 Kingshighway Blvd, St Louis, MO 63110; and Department of Radiology (M.Y., A.K., M.Z.) and Department of Laboratory Medicine and Pathology (M.L.S.), Mayo Clinic Arizona, Scottsdale, Ariz. + + + + Zulfiqar + Maria + M + 0000-0002-8662-3799 + + From the Mallinckrodt Institute of Radiology (M.J.H., B.S.S., D.H.B., C.L.S., A.S.S., V.M.M.) and Department of Pathology (R.C.W.), Washington University School of Medicine, Campus Box 8131, 510 Kingshighway Blvd, St Louis, MO 63110; and Department of Radiology (M.Y., A.K., M.Z.) and Department of Laboratory Medicine and Pathology (M.L.S.), Mayo Clinic Arizona, Scottsdale, Ariz. + + + + eng + + Journal Article + +
+ + United States + Radiographics + 8302501 + 0271-5333 + + IM +
+ + + + 2022 + 12 + 9 + 12 + 52 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + ppublish + + 36490210 + 10.1148/rg.220034 + + +
+ + + 36490206 + + 2022 + 12 + 09 + +
+ + 1097-0347 + + + 2022 + Dec + 09 + + + Head & neck + Head Neck + + Immunonutrition in major oncologic head and neck surgery: Analysis of complications, plasmatic equilibrium, and costs. + 10.1002/hed.27270 + + Malnutrition, in patients with solid tumors, is associated with a worse clinical outcome and about 40% of patients affected by head and neck cancers (HNC) are malnourished at the time of cancer diagnosis. We investigated the potential benefit of a standardized immunonutritional protocol (INP) to patients with HNC receiving major ablative surgery. + An observational study was conducted enrolling 199 patients: 50 treated with the INP and 149 with standard enteral nutrition. Complication rates, need for medications, and costs were considered as outcomes. + INP played a protective role in development of major surgical complications (OR 0.23, p = 0.023), albumin administration (RR 0.38, p = 0.018), and antibiotic duration (p < 0.001) and is cost-effective in patients with moderate or severe malnutrition (-6083€ and -11 988€, p < 0.05). + Our study supports the utility of INP, and accurate nutritional screening can help to identify malnourished patients who would receive the most benefits from this protocol. + © 2022 Wiley Periodicals LLC. + + + + Ascoli + Alessandro + A + https://orcid.org/0000-0002-7375-5581 + + IRCCS Ospedale Policlinico San Martino, Genoa, Italy. + + + Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genova, Genoa, Italy. + + + + Missale + Francesco + F + https://orcid.org/0000-0002-5357-5348 + + IRCCS Ospedale Policlinico San Martino, Genoa, Italy. + + + Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy. + + + Department of Head & Neck Oncology & Surgery Otorhinolaryngology, Antoni Van Leeuwenhoek, Nederlands Kanker Instituut, Amsterdam, The Netherlands. + + + + Giordano + Giorgio-Gregory + GG + https://orcid.org/0000-0002-7853-2889 + + IRCCS Ospedale Policlinico San Martino, Genoa, Italy. + + + Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genova, Genoa, Italy. + + + + Vallin + Alberto + A + https://orcid.org/0000-0003-0471-2286 + + IRCCS Ospedale Policlinico San Martino, Genoa, Italy. + + + Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genova, Genoa, Italy. + + + + Gradaschi + Raffaella + R + + IRCCS Ospedale Policlinico San Martino, Genoa, Italy. + + + Dietetics and Clinical Nutrition Unit, University of Genova, Genoa, Italy. + + + + Guiddo + Erica + E + + IRCCS Ospedale Policlinico San Martino, Genoa, Italy. + + + Dietetics and Clinical Nutrition Unit, University of Genova, Genoa, Italy. + + + + Schenone + Guido + G + + IRCCS Ospedale Policlinico San Martino, Genoa, Italy. + + + + Sukkar + Samir Giuseppe + SG + + IRCCS Ospedale Policlinico San Martino, Genoa, Italy. + + + Dietetics and Clinical Nutrition Unit, University of Genova, Genoa, Italy. + + + + Copello + Francesco + F + + IRCCS Ospedale Policlinico San Martino, Genoa, Italy. + + + Occupational Medicine Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy. + + + + Parrinello + Giampiero + G + + IRCCS Ospedale Policlinico San Martino, Genoa, Italy. + + + + Iandelli + Andrea + A + https://orcid.org/0000-0003-1187-3045 + + IRCCS Ospedale Policlinico San Martino, Genoa, Italy. + + + + Peretti + Giorgio + G + + IRCCS Ospedale Policlinico San Martino, Genoa, Italy. + + + Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genova, Genoa, Italy. + + + + Marchi + Filippo + F + https://orcid.org/0000-0002-7997-964X + + IRCCS Ospedale Policlinico San Martino, Genoa, Italy. + + + Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genova, Genoa, Italy. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + Head Neck + 8902541 + 1043-3074 + + IM + + albumin + complications + cost analysis + head and neck cancer + immunonutrition + surgery + +
+ + + + 2022 + 10 + 27 + + + 2022 + 06 + 22 + + + 2022 + 11 + 23 + + + 2022 + 12 + 9 + 12 + 42 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36490206 + 10.1002/hed.27270 + + + REFERENCES + + Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010;127(12):2893-2917. + + + Simard EP, Torre LA, Jemal A. International trends in head and neck cancer incidence rates: differences by country, sex and anatomic site. Oral Oncol. 2014;50(5):387-403. + + + Hammerlid E, Wirblad B, Sandin C, et al. Malnutrition and food intake in relation to quality of life in head and neck cancer patients. Head Neck. 1998;20(6):540-548. + + + van Wayenburg CAM, Rasmussen-Conrad EL, van den Berg MGA, et al. Weight loss in head and neck cancer patients little noticed in general practice. J Prim Health Care. 2010;2(1):16-21. + + + Ackerman D, Laszlo M, Provisor A, Yu A. Nutrition management for the head and neck cancer patient. Cancer Treat Res. 2018;174:187-208. + + + de van derSchuer B, van Leeuwen PA, Kuik DJ, et al. The impact of nutritional status on the prognoses of patients with advanced head and neck cancer. Cancer. 1999;86(3):519-527. + + + Yanni A, Dequanter D, Lechien JR, et al. Malnutrition in head and neck cancer patients: impacts and indications of a prophylactic percutaneous endoscopic gastrostomy. Eur Ann Otorhinolaryngol Head Neck Dis. 2019;136(3):S27-S33. + + + Geeganage C, Beavan J, Ellender S, Bath PMW. Interventions for dysphagia and nutritional support in acute and subacute stroke. Cochrane Database Syst Rev. 2012;10:CD000323. + + + Bianchini C, Ciorba A, Stomeo F, Pelucchi S, Pastore A. Immunonutrition in head and neck cancer: Have a look before surgery! Eur Arch Otorhinolaryngol. 2012;269(1):5-8. + + + Correia MITD, Waitzberg DL. The impact of malnutrition on morbidity, mortality, length of hospital stay and costs evaluated through a multivariate model analysis. Clin Nutr. 2003;22(3):235-239. + + + Spiro A, Baldwin C, Patterson A, Thomas J, Andreyev HJN. The views and practice of oncologists towards nutritional support in patients receiving chemotherapy. Br J Cancer. 2006;95(4):431-434. + + + Sorensen J, Kondrup J, Prokopowicz J, et al. EuroOOPS: an international, multicentre study to implement nutritional risk screening and evaluate clinical outcome. Clin Nutr. 2008;27(3):340-349. + + + Senesse P, Assenat E, Schneider S, et al. Nutritional support during oncologic treatment of patients with gastrointestinal cancer: who could benefit? Cancer Treat Rev. 2008;34(6):568-575. + + + Dewys WD, Begg C, Lavin PT, et al. Prognostic effect of weight loss prior to chemotherapy in cancer patients. Eastern Cooperative Oncology Group. Am J Med. 1980;69(4):491-497. + + + Pan H, Cai S, Ji J, et al. The impact of nutritional status, nutritional risk, and nutritional treatment on clinical outcome of 2248 hospitalized cancer patients: a multi-center, prospective cohort study in chinese teaching hospitals. Nutr Cancer. 2013;65(1):62-70. + + + Wie G-A, Cho Y-A, Kim S-Y, Kim S-M, Bae J-M, Joung H. Prevalence and risk factors of malnutrition among cancer patients according to tumor location and stage in the National Cancer Center in Korea. Nutrition. 2010;26(3):263-268. + + + Iwamoto M, Higashibeppu N, Arioka Y, Nakaya Y. Swallowing rehabilitation with nutrition therapy improves clinical outcome in patients with dysphagia at an acute care hospital. J Med Invest. 2014;61(3-4):353-360. + + + Ordoñez AM, Madalozzo Schieferdecker ME, Cestonaro T, Cardoso Neto J, Ligocki Campos AC. Nutritional status influences the length of stay and clinical outcomes in patients hospitalized in internal medicine wards. Nutr Hosp. 2013;28(4):1313-1320. + + + Pearce CB, Duncan HD. Enteral feeding. Nasogastric, nasojejunal, percutaneous endoscopic gastrostomy, or jejunostomy: its indications and limitations. Postgrad Med J. 2002;78(918):198-1204. + + + Valente da Silva HG, Santos SO, Silva NO, Ribeiro FD, Josua LL, Moreira ASB. Nutritional assessment associated with length of inpatients' hospital stay. Nutr Hosp. 2012;27(2):542-547. + + + Howes N, Atkinson C, Thomas S, Lewis SJ. Immunonutrition for patients undergoing surgery for head and neck cancer. Cochrane Database Syst Rev. 2018;8(8):CD010954. + + + Falewee MN, Schilf A, Boufflers E, et al. Reduced infections with perioperative immunonutrition in head and neck cancer: exploratory results of a multicenter, prospective, randomized, double-blind study. Clin Nutr. 2014;33(5):776-784. + + + de Luis DA, Culebras JM, Aller R, Eiros-Bouza JM. Surgical infection and malnutrition. Nutr Hosp. 2014;30(3):509-513. + + + Chandra RK. Nutrition and the immune system: an introduction. Am J Clin Nutr. 1997;66(2):460-463. + + + Gombart AF, Pierre A, Maggini S. A review of micronutrients and the immune system-working in harmony to reduce the risk of infection. Nutrients. 2020;12(1):236. + + + Di Carlo V, Gianotti L, Balzano G, Zerbi A, Braga M. Complications of pancreatic surgery and the role of perioperative nutrition. Dig Surg. 1999;16(4):320-326. + + + Gianotti L, Braga M, Nespoli L, Radaelli G, Beneduce A, Di Carlo V. A randomized controlled trial of preoperative oral supplementation with a specialized diet in patients with gastrointestinal cancer. Gastroenterology. 2002;122(7):1763-1770. + + + Wu GH, Zhang YW, Wu ZH. Modulation of postoperative immune and inflammatory response by immune-enhancing enteral diet in gastrointestinal cancer patients. World J Gastroenterol. 2001;7(3):357-362. + + + Piazza C, Del Bon F, Peretti G, Nicolai P. Narrow band imaging in endoscopic evaluation of the larynx. Curr Opin Otolaryngol Head Neck Surg. 2012;20(6):472-476. + + + Piazza C, Del Bon F, Paderno A, et al. The diagnostic value of narrow band imaging in different oral and oropharyngeal subsites. Eur Arch Otorhinolaryngol. 2016;273(10):3347-3353. + + + Seeburg DP, Baer AH, Aygun N. Imaging of patients with head and neck cancer: from staging to surveillance. Oral Maxillofac Surg Clin North Am. 2018;30(4):421-433. + + + Amin MB, Edge SB. AJCC Cancer Staging Manual. Vol 17. Springer; 2017:1032. + + + Dripps RD. New classification of physical status. Anesthesiology. 1963;24:111. + + + Kondrup J, Rasmussen HH, Hamberg O, Stanga Z. Nutritional risk screening (NRS 2002): a new method based on an analysis of controlled clinical trials. Clin Nutr. 2003;22(3):321-336. + + + Lam P, Stanschus S, Zaman R, Cichero JA. The International Dysphagia Diet Standardisation Initiative (IDDSI) framework: the Kempen pilot. Br J Neurosci Nurs. 2017;13(Suppl. 2):S18-S26. + + + Müller-Richter U, Betz C, Hartmann S, Brands RC. Nutrition management for head and neck cancer patients improves clinical outcome and survival. Nutr Res. 2017;48:1-8. + + + Barazzoni R, Deutz NEP, Biolo G, et al. Carbohydrates and insulin resistance in clinical nutrition: recommendations from the ESPEN expert group. Clin Nutr. 2017;36(2):355-363. + + + Duncan AE. Hyperglycemia and perioperative glucose management. Curr Pharm des. 2012;18(38):6195-6203. + + + Kirk SJ, Barbul A. Role of arginine in trauma, sepsis, and immunity. JPEN J Parenter Enteral Nutr. 1990;14(Suppl. 5):226-229. + + + Ljungqvist O. ERAS-enhanced recovery after surgery: moving evidence-based perioperative care to practice. JPEN J Parenter Enteral Nutr. 2014;38(5):559-566. + + + Riso S, Aluffi P, Brugnani M, Farinetti F, Pia F, D'Andrea F. Postoperative enteral immunonutrition in head and neck cancer patients. Clin Nutr. 2000;19(6):407-412. + + + Forget P, Echeverria G, Giglioli S, Bertrand B, et al. Biomarkers in immunonutrition programme, is there still a need for new ones? A brief review. Ecancermedicalscience. 2015;9:546. + + + Alshadwi A, Nadershah M, Carlson ER, Young LS, Burke PA, Daley BJ. Nutritional considerations for head and neck cancer patients: a review of the literature. J Oral Maxillofac Surg. 2013;71(11):1853-1860. + + + vanBokhorst-de van der Schueren MA, van Leeuwen PA, Sauerwein HP, Kuik DJ, Snow GB, Quak JJ. Assessment of malnutrition parameters in head and neck cancer and their relation to postoperative complications. Head Neck. 1997;19(5):419-425. + + + Friedlander AH, Tajima T, Kawakami KT, Wang MB, Tomlinson J. The relationship between measures of nutritional status and masticatory function in untreated patients with head and neck cancer. J Oral Maxillofac Surg. 2008;66(1):85-92. + + + Penn I. Immunosuppression and cancer. Importance in head and neck surgery. Arch Otolaryngol. 1975;101(11):667-670. + + + Duray A, Demoulin S, Hubert P, Delvenne P, Saussez S. Immune suppression in head and neck cancers: a review. Clin Dev Immunol. 2010;2010:1-15. + + + Tong CCL, Kao J, Sikora AG. Recognizing and reversing the immunosuppressive tumor microenvironment of head and neck cancer. Immunol Res. 2012;54(1-3):266-274. + + + Fanslow WC, Kulkarni AD, Van Buren CT, Rudolph FB. Effect of nucleotide restriction and supplementation on resistance to experimental murine candidiasis. JPEN J Parenter Enteral Nutr. 1988;12(1):49-52. + + + Surette ME. The science behind dietary omega-3 fatty acids. C Can Med Assoc J. 2008;178(2):177-180. + + + Aeberhard C, Mayer C, Meyer S, et al. Effect of preoperative immunonutrition on postoperative short-term outcomes of patients with head and neck squamous cell carcinoma. Head Neck. 2018;40(5):1057-1067. + + + Marimuthu K, Varadhan KK, Ljungqvist O, Lobo DN. A meta-analysis of the effect of combinations of immune modulating nutrients on outcome in patients undergoing major open gastrointestinal surgery. Ann Surg. 2012;255(6):1060-1068. + + + Zhang Y, Gu Y, Guo T, Li Y, Cai H. Perioperative immunonutrition for gastrointestinal cancer: a systematic review of randomized controlled trials. Surg Oncol. 2012;21(2):e87-e95. + + + Weimann A, Braga M, Carli F, et al. ESPEN guideline: Clinical nutrition in surgery. Clin Nutr. 2017;36(3):623-650. + + + Stableforth WD, Thomas S, Lewis SJ. A systematic review of the role of immunonutrition in patients undergoing surgery for head and neck cancer. Int J Oral Maxillofac Surg. 2009;38(2):103-110. + + + Mueller SA, Mayer C, Bojaxhiu B, et al. Effect of preoperative immunonutrition on complications after salvage surgery in head and neck cancer. J Otolaryngol Head Neck Surg. 2019;48(1):1-9. + + + Rowan NR, Johnson JT, Fratangelo CE, Smith BK, Kemerer PA, Ferris RL. Utility of a perioperative nutritional intervention on postoperative outcomes in high-risk head & neck cancer patients. Oral Oncol. 2016;54:42-46. + + + Vidal-Casariego A, Calleja-Fernández A, Villar-Taibo R, Kyriakos G, Ballesteros-Pomar MD. Efficacy of arginine-enriched enteral formulas in the reduction of surgical complications in head and neck cancer: a systematic review and meta-analysis. Clin Nutr. 2014;33(6):951-957. + + + de Luis DA, Izaola O, Cuellar L, Terroba MC, Martin T, Aller R. Clinical and biochemical outcomes after a randomized trial with a high dose of enteral arginine formula in postsurgical head and neck cancer patients. Eur J Clin Nutr. 2007;61(2):200-204. + + + van Bokhorst-de van der Schueren MA, Quak JJ, von Blomberg-van der Flier BM, et al. Effect of perioperative nutrition, with and without arginine supplementation, on nutritional status, immune function, postoperative morbidity, and survival in severely malnourished head and neck cancer patients. Am J Clin Nutr. 2001;73(2):323-332. + + + Mueller SA, Mayer C, Bojaxhiu B, et al. Effect of preoperative immunonutrition on complications after salvage surgery in head and neck cancer. J Otolaryngol Head Neck Surg. 2019;48(1):25. + + + de Luis DA, Aller R, Izaola O, Cuellar L, Terroba MC. Postsurgery enteral nutrition in head and neck cancer patients. Eur J Clin Nutr. 2002;56(11):1126-1129. + + + Nicholson JP, Wolmarans MR, Park GR. The role of albumin in critical illness. Br J Anaesth. 2000;85(4):599-610. + + + Huang W, Tang Y, Nong L, Sun Y. Risk factors for postoperative intra-abdominal septic complications after surgery in Crohn's disease: a meta-analysis of observational studies. J Crohns Colitis. 2015;9(3):293-301. + + + Galata C, Busse L, Birgin E, et al. Role of albumin as a nutritional and prognostic marker in elective intestinal surgery. Can J Gastroenterol Hepatol. 2020;2020:7028216-7028218. + + + Truong A, Hanna MH, Moghadamyeghaneh Z, Stamos MJ. Implications of preoperative hypoalbuminemia in colorectal surgery. World J Gastrointest Surg. 2016;8(5):353-362. + + + Braga M, Gianotti L, Vignali A, Schmid A, Nespoli L, Di Carlo V. Hospital resources consumed for surgical morbidity: effects of preoperative arginine and omega-3 fatty acid supplementation on costs. Nutrition. 2005;21(11-12):1078-1086. + + + +
+ + + 36490219 + + 2022 + 12 + 09 + +
+ + 1522-726X + + + 2022 + Dec + 09 + + + Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions + Catheter Cardiovasc Interv + + Incidence and severity of thrombocytopenia associated with use of intravascular microaxial ventricular assist devices for treatment of cardiogenic shock. + 10.1002/ccd.30520 + + The use of temporary mechanical circulatory support (MCS) for patients with refractory cardiogenic shock has increased over the past decade. Impella devices (intravascular microaxial ventricular assist devices [VADs]) have become common MCS options but reportedly cause thrombocytopenia. Limited published data regarding the incidence or severity of microaxial VAD-associated thrombocytopenia exists. + The goal of this study was to determine the incidence, timing, and severity of thrombocytopenia in a microaxial VAD population. + A retrospective multicenter review of electronic medical records identified all patients implanted with microaxial VAD at three US academic teaching hospitals between June 2015 and August 2017. Patients were excluded for short-term procedural microaxial VAD use during percutaneous coronary intervention. + Sixty-four patients underwent microaxial VAD insertion (95% for left-sided support) during the observed time period. Support was in place for a median duration of 5.2 (interquartile range [IQR]: 2.4-10.0) days. Within 7 days postinsertion, 98.5% of patients developed thrombocytopenia (platelet count <150,000/μl) and 81.3% of patients experienced a >50% platelet decrease. Average platelet count nadir was 68,200/μl or 63.9% from baseline occurring on median day 3.8 (IQR: 2.4-5.4). Twenty-four patients (38.1%) were tested for heparin-induced thrombocytopenia by the heparin-dependent antibody (HDA) test. All HDAs were either negative or had serotonin release assay negative confirmation. Postdevice removal, platelet counts returned to baseline or >150,000/μl in 63% of patients by Day 5. + Microaxial VAD-associated thrombocytopenia is common. Practitioners should consider this when evaluating supported patients for other causes of thrombocytopenia. Platelet counts return to preimplantation levels within days of device removal. + © 2022 Wiley Periodicals LLC. + + + + Goetz + Jenna + J + https://orcid.org/0000-0003-3083-8050 + + Department of Pharmacy, Barnes Jewish Hospital, St Louis, Missouri, USA. + + + + O'Brien + Michael + M + + Department of Pharmacy, Massachusetts General Hospital, Boston, Massachusetts, USA. + + + + Bream-Rouwenhorst + Heather + H + + Department of Pharmaceutical Care, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA. + + + + Toyoda + Alexander + A + + Department of Pharmacy, Massachusetts General Hospital, Boston, Massachusetts, USA. + + + + Hobbs + Ryan + R + + Department of Pharmaceutical Care, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA. + + + + Horwitz + Phillip A + PA + + Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + Catheter Cardiovasc Interv + 100884139 + 1522-1946 + + IM + + anticoagulation + critical care + microaxial ventricular assist device + thrombocytopenia + +
+ + + + 2022 + 10 + 31 + + + 2022 + 05 + 24 + + + 2022 + 11 + 28 + + + 2022 + 12 + 9 + 13 + 2 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36490219 + 10.1002/ccd.30520 + + + REFERENCES + + Shishehbor MH, Moazami N, Tong MZY, Unai S, Tang WHW, Soltesz EG. Cardiogenic shock: from ECMO to Impella and beyond. Cleve Clin J Med. 2017;84(4):287-295. + + + Pieri M, Contri R, Winterton D, et al. The contemporary role of Impella in a comprehensive mechanical circulatory support program: a single institutional experience. BMC Cardiovasc Disord. 2015;15:126. + + + Sodhi N, Lasala JM. Mechanical circulatory support in acute decompensated heart failure and shock. Interventional Cardiology Clinics. 2017;6(3):387-405. + + + Abiomed Inc. Impella 2.5 with the Automated Impella Controller Instructions for Use & Clinical Reference Manual. Abiomed Inc.; 2009. https://www.accessdata.fda.gov/cdrh_docs/pdf14/P140003c.pdf + + + Laliberte B, Reed BN. Use of an argatroban-based purge solution in a percutaneous ventricular assist device. Am J Health Syst Pharm. 2017;74(9):e163-e169. + + + Newsome AS, Taylor A, Garner S. Anticoagulation of a percutaneous left ventricular assist device using a low-dose heparin purge solution protocol: a case series. J Pharm Pract. 2020;33(4):471-476. + + + Shuster M, Konopka CI, Verlinden NJ. Incidence and timing of thrombocytopenia in patients receiving impella ventricular assist device support. ASAIO J. 2022;68:1135-1140. + + + Blum EC, Martz CR, Selektor Y, Nemeh H, Smith ZR, To L. Anticoagulation of percutaneous ventricular assist device using argatroban-based purge solution: a case series. J Pharm Pract. 2018;31(5):514-518. + + + Williamson DR, Albert M, Heels-Ansdell D, et al. Thrombocytopenia in critically ill patients receiving thromboprophylaxis. Chest. 2013;144(4):1207-1215. + + + Bream-rouwenhorst HR, Hobbs RA, Horwitz PA. Thrombocytopenia in patients treated with heparin, combination antiplatelet therapy, and intra-aortic balloon pump counterpulsation. J Interv Cardiol. 2008;21(4):350-356. + + + Arachchillage DRJ, Laffan M, Khanna S, et al. Frequency of thrombocytopenia and heparin-induced thrombocytopenia in patients receiving extracorporeal membrane oxygenation compared with cardiopulmonary bypass and the limited sensitivity of pretest probability score. Crit Care Med. 2020;48(5):e371-e379. + + + Sugimura Y, Bauer S, Immohr MB, et al. Heparin-induced thrombocytopenia under mechanical circulatory support by large impella for acute cardiogenic shock. J Cardiovasc Dev Dis. 2021;8(12):161. + + + Hohlfelder B, Militello MA, Tong MZ, Soltesz EG, Wanek MR. Anticoagulation with temporary Impella device in patients with heparin-induced thrombocytopenia: a case series. Int J Artif Organs. 2021;44(5):367-370. + + + Beavers CJ, DiDomenico RJ, Dunn SP, et al. Optimizing anticoagulation for patients receiving Impella support. Pharmacotherapy. 2021;41(11):932-942. + + + Al-Ayoubi AM, Bhavsar K, Hobbs RA, et al. Use of sodium bicarbonate purge solution in impella devices for heparin-induced thrombocytopenia. J Pharm Pract. 2022;44:8971900221089078. + + + Abiomed Inc. Impella Update: Use of Sodium Bicarbonate in Impella Pumps. Abiomed Inc.; 2021. Accessed online at: Impella Update: Use of Sodium Bicarbonate in Impella® Pumps | HeartRecovery.com. + + + +
+ + + 36490207 + + 2022 + 12 + 09 + +
+ + 1527-1323 + + 43 + 1 + + 2023 + Jan + + + Radiographics : a review publication of the Radiological Society of North America, Inc + Radiographics + + Sedation in Pediatric Imaging. + + e220168 + + 10.1148/rg.220168 + + + Merchant + Suleman Adam + SA + 0000-0001-6513-450X + + Radiology Department, Lokmanya Tilak Municipal Medical College and General Hospital, Mumbai 400022, India. + + + + Nadkarni + Prakash M + PM + + College of Nursing, University of Iowa Hospitals and Clinics, Iowa City, IA. + + + + eng + + Letter + +
+ + United States + Radiographics + 8302501 + 0271-5333 + + IM +
+ + + + 2022 + 12 + 9 + 12 + 52 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + ppublish + + 36490207 + 10.1148/rg.220168 + + +
+ + + 36490217 + + 2022 + 12 + 09 + +
+ + 1477-0962 + + + 2022 + Dec + 09 + + + Lupus + Lupus + + Relapses are common in severe hematologic systemic lupus erythematosus and may be prevented by early institution of immunosuppressive agents: Α real-life single-center study. + + 9612033221144425 + + 10.1177/09612033221144425 + + Hematologic manifestations are common in systemic lupus erythematosus (SLE), either at initial presentation or during the course of the disease, but data regarding their natural history are scarce. + To describe the characteristics, treatments, and outcomes of severe hematological manifestations in a large cohort of lupus patients. + Retrospective cohort study of patients in the "Attikon" lupus cohort who had a history of a severe hematologic manifestation, defined as autoimmune hemolytic anemia (AIHA) with hemoglobin < 8 g/dL, thrombocytopenia with platelet count < 30,000/mm3, Evans syndrome with hemoglobin < 8 g/dL, and/or platelet count < 30,000/mm3, neutropenia with < 500 neutrophils/mm3, thrombotic microangiopathy (TMA)/thrombotic thrombocytopenic purpura (TTP)-like syndrome, or macrophage activation syndrome (MAS). Demographic and clinical characteristics, treatments, and outcomes were recorded. + From over 300 patients with hematologic manifestations, 41 qualified as severe (70.7% women, mean [SD] age at SLE diagnosis 42.6 [18.0] years). Hematologic manifestations preceded SLE diagnosis in 13 patients (31.7%), was concomitant to SLE diagnosis in 16 patients (39%), and occurred during the course of the disease in 12 (29.3%) patients, with a mean (SD) disease duration of 8.7 (5.5) years. Thrombocytopenia was the most common severe hematological manifestation (56.1%), followed by AIHA (17.1%) and TTP-like syndrome (12.2%). For initial treatment, all patients were treated with glucocorticoids (GC), while rituximab and cyclophosphamide were the most frequently used immunosuppressive agents. Following initial treatment, relapse occurred in 22 patients (53.7%). Compared to patients that did not relapse, those that relapsed had less often received concomitant immunosuppressive agents following treatment of initial episode (n = 17/23, 73.9% vs 5/17, 29.4%, p = 0.005). + Severe hematologic disease in SLE has a high risk of relapse, which may be mitigated by the early institution of GC-sparing agents. + + + + Moysidou + Georgia-Savina + GS + 0000-0002-7591-9797 + + Rheumatology and Clinical Immunology Unit, 4th Department of Internal Medicine, Attikon University Hospital, Athens, Greece. + + + Faculty of Medicine, National and Kapodistrian University of Athens, Inflammation & Autoimmunity Lab, Biomedical Research Foundation of the Academy of Athens (BRFAA), Athens, Greece. + + + + Garantziotis + Panagiotis + P + + Faculty of Medicine, National and Kapodistrian University of Athens, Inflammation & Autoimmunity Lab, Biomedical Research Foundation of the Academy of Athens (BRFAA), Athens, Greece. + + + + Nikolopoulos + Dionysis + D + 0000-0002-9894-6966 + + Faculty of Medicine, National and Kapodistrian University of Athens, Inflammation & Autoimmunity Lab, Biomedical Research Foundation of the Academy of Athens (BRFAA), Athens, Greece. + + + + Katsimbri + Pelagia + P + + Rheumatology and Clinical Immunology Unit, 4th Department of Internal Medicine, Attikon University Hospital, Athens, Greece. + + + + Fanouriakis + Antonis + A + + Rheumatology and Clinical Immunology Unit, 4th Department of Internal Medicine, Attikon University Hospital, Athens, Greece. + + + 1st Department of Propaedeutic Internal Medicine, "Laiko" General Hospital, Athens, Greece. + + + Joint Academic Rheumatology Program, National and Kapodistrian University of Athens Medical School, Athens, Greece. + + + + Boumpas + Dimitrios T + DT + + Rheumatology and Clinical Immunology Unit, 4th Department of Internal Medicine, Attikon University Hospital, Athens, Greece. + + + Faculty of Medicine, National and Kapodistrian University of Athens, Inflammation & Autoimmunity Lab, Biomedical Research Foundation of the Academy of Athens (BRFAA), Athens, Greece. + + + Joint Academic Rheumatology Program, National and Kapodistrian University of Athens Medical School, Athens, Greece. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + England + Lupus + 9204265 + 0961-2033 + + IM + + haematologic changes + systemic lupus erythematosus + treatment + +
+ + + + 2022 + 12 + 9 + 13 + 2 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36490217 + 10.1177/09612033221144425 + + +
+ + + 36490220 + + 2022 + 12 + 09 + +
+ + 1365-2923 + + + 2022 + Dec + 09 + + + Medical education + Med Educ + + Health Advocacy Among Medical Learners: Unpacking Contextual Barriers and Affordances. + 10.1111/medu.15001 + + Learners and physicians are expected to practice as health advocates in Canadian contexts, but they rarely feel competent to practice this critical role when they complete their training. This is in part because advocacy is seen as "going above and beyond" routine practice and pushing the boundaries of systems that are resistant to change. Medical learning contexts are rife with barriers to learning about and practicing advocacy, and there is now a need to understand how contexts impact advocacy. + Using constructivist grounded theory study, we generated data through individual and group interviews with medical learners to explore the barriers and facilitators to advocacy in a variety of learning/practice contexts. We used purposeful and theoretical sampling to ensure that diverse learning contexts and learners who had different views on advocacy were represented. We constructed a theoretical model to understand advocacy decision making through cycles of initial, focused, and theoretical coding, using constant comparative analysis. + Learners' thinking about health advocacy was framed by their own unique knowledge and beliefs, as well as their institutional and organizational contexts. With these influences in mind, learners made decisions about when to advocate within a local decision-making context, guided by affordances and barriers to advocacy involved in their perceptions of: the patient, their own social position, resources available, and social norms. + This framework highlights critical aspects of context that influence learners' ability to learn about and practice as health advocates. If we are to adequately prepare learners for this important work, we must address aspects of their learning and practice contexts that make this work daunting, while we offer learners the tools required to address contexts that do not always support their efforts. + This article is protected by copyright. All rights reserved. + + + + Kahlke + Renate + R + https://orcid.org/0000-0002-4473-5039 + + Division of Education and Innovation, Department of Medicine and Scientist in the Medical Education Research, Innovation and Theory Program, McMaster University, Hamilton, ON, Canada. + + + + Scott + Ian + I + + Department of Family Practice and Director of the Centre for Health Education Scholarship, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada. + + + + van der Goes + Theresa + T + + Department of Family Practice, Faculty of Medicine, University of British Columbia, Nanaimo, BC, Canada. + + + + Hubinette + Maria M + MM + https://orcid.org/0000-0002-7928-555X + + Department of Family Practice and Scholar in the Centre for Health Education Scholarship, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + England + Med Educ + 7605655 + 0308-0110 + + IM +
+ + + + 2022 + 11 + 12 + + + 2022 + 07 + 20 + + + 2022 + 12 + 06 + + + 2022 + 12 + 9 + 13 + 2 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36490220 + 10.1111/medu.15001 + + +
+ + + 36490212 + + 2022 + 12 + 09 + +
+ + 1527-1323 + + 43 + 1 + + 2023 + Jan + + + Radiographics : a review publication of the Radiological Society of North America, Inc + Radiographics + + Comprehensive Palliative Musculoskeletal Interventional Radiology Care for Patients with Cancer. + + e229014 + + 10.1148/rg.229014 + + + Tomasian + Anderanik + A + + + Filippiadis + Dimitrios K + DK + + + Tutton + Sean + S + + + Deschamps + Frédéric + F + + + Cazzato + Roberto Luigi + RL + + + Prologo + John D + JD + + + Kelekis + Alexis + A + + + Levy + Jason + J + + + Gangi + Afshin + A + + + Garnon + Julien + J + + + Jennings + Jack W + JW + + + eng + + Published Erratum + +
+ + United States + Radiographics + 8302501 + 0271-5333 + + IM + + + Radiographics. 2022 Oct;42(6):1654-1669 + 36190860 + + +
+ + + + 2022 + 12 + 9 + 12 + 52 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + ppublish + + 36490212 + 10.1148/rg.229014 + + +
+ + + 36490214 + + 2022 + 12 + 09 + +
+ + 1552-5279 + + + 2022 + Dec + 09 + + + Alzheimer's & dementia : the journal of the Alzheimer's Association + Alzheimers Dement + + Alzheimer's Association names Dr. Joanne Pike its next chief executive officer. + 10.1002/alz.12911 + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + Alzheimers Dement + 101231978 + 1552-5260 + + IM +
+ + + + 2022 + 12 + 9 + 12 + 52 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36490214 + 10.1002/alz.12911 + + +
+ + + 36490213 + + 2022 + 12 + 09 + +
+ + 1938-291X + + + 2022 + Dec + 09 + + + Journal of economic entomology + J Econ Entomol + + Stable Isotopes Indicate Seasonal Changes in Natal Geographic Origins and Host Plants of Ostrinia furnacalis (Guenée) Migrants Across the Bohai Strait in China. + toac195 + 10.1093/jee/toac195 + + The Asian corn borer, Ostrinia furnacalis (Guenée), is a notorious pest of maize that migrates seasonally in Asia. Two migration peaks were found on Beihuang island in the Bohai Strait of China by observing the number of migrants. However, the origins and host plants of the migrants in the two migration periods remain unclear. Here, stable hydrogen (δ2H) and carbon (δ13C) isotope levels were measured to infer the origin and host plants of the O. furnacalis captured on Beihuang island in 2017-2019. δ2H in wings of spring-summer O. furnacalis captured from May to June ranged from -99 to -56‰, while that of autumn migrants from August to September ranged from -127 to -81‰. Based on the linear relationship between δ2H in the wing of migrants (δ2Hw) and δ2H in precipitation (δ2Hp), the spring-summer O. furnacalis likely originated from the summer maize area in the Huang-Huai-Hai Plain in China. In contrast, the autumn migrants came from the northern spring maize area in Liaoning, Jilin and Inner Mongolia. Based on δ13C, the spring-summer migrants fed on both C3 plants such as wheat (47.76%) and C4 weeds or belonged to the over winter individuals in maize field (52.24%), while the autumn migrants mainly fed on maize (C4, 91.21%). The results point to a northward migration in spring-summer and southward migration in autumn of O. furnacalis. Our study gives an important knowledge for improving the forecasting and management level of this pest. + © The Author(s) 2022. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. + + + + Shen + Xiujing + X + + State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, 100193, PR China. + + + Institute of Plant Protection, Beijing Academy of Agriculture and Forestry Sciences, Beijing, 100097, PR China. + + + + Guo + Jianglong + J + + State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, 100193, PR China. + + + Key Laboratory of Integrated Pest Management on Crops in Northern Region of North China, Ministry of Agriculture and Rural Affairs, IPM Center of Hebei Province, Plant Protection Institute, Hebei Academy of Agricultural and Forestry Sciences, Baoding, 071000, PR China. + + + + Yang + Xianming + X + + State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, 100193, PR China. + + + + Wei + Shujun + S + 0000-0001-7398-0968 + + Institute of Plant Protection, Beijing Academy of Agriculture and Forestry Sciences, Beijing, 100097, PR China. + + + + Wu + Kongming + K + 0000-0002-6130-4572 + + State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, 100193, PR China. + + + + eng + + + 31727901 + National Natural Sciences Foundation of China + + + + CARS-02 + China Agriculture Research System + + + + + Journal Article + + + 2022 + 12 + 09 + +
+ + England + J Econ Entomol + 2985127R + 0022-0493 + + IM + + + Ostrinia furnacalis + + host plant + origin + seasonal migration + stable isotope + +
+ + + + 2022 + 07 + 20 + + + 2022 + 12 + 9 + 12 + 52 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36490213 + 6885486 + 10.1093/jee/toac195 + + +
+ + + 36490216 + + 2022 + 12 + 09 + +
+ + 1097-0347 + + + 2022 + Dec + 09 + + + Head & neck + Head Neck + + Cross-legged modification for medial sural artery perforator flap harvest. + 10.1002/hed.27263 + + When thin and pliable free tissue is needed, the medial sural artery perforator (MSAP) flap provides an excellent option with minimal donor site morbidity. However, among its pitfalls include difficult patient positioning and surgeon ergonomics throughout the harvest. We describe a novel positioning technique that may significantly improve surgeon ergonomics and ease of MSAP flap harvest. A cross-legged modification may eliminate many of the issues associated with the classic frog-leg position. While the patient is cross-legged, the surgeon is afforded a normal field of view that is closer to their body, while simultaneously providing support to the lateral side of the gastrocnemius muscle. This pictorial essay describes this positioning technique and subsequent harvest. By incorporating a more ergonomic cross-legged position during flap elevation, many of thedrawbacks of the MSAP flap could be eliminated. + © 2022 Wiley Periodicals LLC. + + + + Feng + Allen L + AL + https://orcid.org/0000-0002-8040-5299 + + Department of Otolaryngology - Head and Neck Surgery, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA. + + + + Spector + Matthew E + ME + + Department of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA. + + + + Chinn + Steven B + SB + + Department of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA. + + + + Holcomb + Andrew J + AJ + https://orcid.org/0000-0001-8397-2312 + + Department of Otolaryngology - Head and Neck Surgery, Methodist Estabrook Cancer Center, Omaha, Nebraska, USA. + + + + Davies + Joel C + JC + + Department of Otolaryngology - Head and Neck Surgery, University of Toronto, Toronto, Ontario, Canada. + + + + Richmon + Jeremy D + JD + + Department of Otolaryngology - Head and Neck Surgery, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA. + + + + Lin + Derrick T + DT + + Department of Otolaryngology - Head and Neck Surgery, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA. + + + + Varvares + Mark A + MA + https://orcid.org/0000-0002-6570-5672 + + Department of Otolaryngology - Head and Neck Surgery, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + Head Neck + 8902541 + 1043-3074 + + IM + + MSAP flap + calf flap + head and neck reconstruction + medial sural artery + perforator flap + +
+ + + + 2022 + 10 + 25 + + + 2022 + 09 + 01 + + + 2022 + 11 + 23 + + + 2022 + 12 + 9 + 13 + 2 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36490216 + 10.1002/hed.27263 + + + REFERENCES + + Cavadas PC, Sanz-Gimenez-Rico JR, Gutierrez-de la Camara A, Navarro-Monzonis A, Soler-Nomdedeu S, Martinez-Soriano F. The medial sural artery perforator free flap. Plast Reconstr Surg. 2001;108:1609-1615. discussion 1616-1607. + + + Feng AL, Nasser HB, Casper KA, et al. The medial sural artery perforator flap: an underutilized flap in oral cavity reconstruction. Oral Oncol. 2022;124:105417. + + + Toyserkani NM, Sorensen JA. Medial sural artery perforator flap: a challenging free flap. Eur J Plast Surg. 2015;38:391-396. + + + Kao HK, Chang KP, Wei FC, Cheng MH. Comparison of the medial sural artery perforator flap with the radial forearm flap for head and neck reconstructions. Plast Reconstr Surg. 2009;124:1125-1132. + + + Howell A, Bartram A, Nugent M. Split table improves access for harvest of medial sural artery perforator flap. Br J Oral Maxillofac Surg. 2015;53:894. + + + Deek NFA, Hsiao JC, Do NT, et al. The medial sural artery perforator flap: lessons learned from 200 consecutive cases. Plast Reconstr Surg. 2020;146:630e-641e. + + + Lee CH, Chang NT, Hsiao JC, et al. Extended use of chimeric medial sural artery perforator flap for 3-dimensional defect reconstruction. Ann Plast Surg. 2019;82:S86-S94. + + + Akdeniz Dogan ZD, Cavus Ozkan M, Tuncer FB, Sacak B, Celebiler O. A comparative clinical study of flap thickness: medial sural artery perforator flap versus anterolateral thigh flap. Ann Plast Surg. 2018;81:472-474. + + + He Y, Jin SF, Zhang CP, Zhang ZY. Medial sural artery perforator flap aided by preoperative computed tomography angiography mapping for tongue reconstruction. Int J Oral Maxillofac Surg. 2014;43:1064-1068. + + + +
+ + + 36490215 + + 2022 + 12 + 09 + +
+ + 1877-8879 + + + 2022 + Dec + 09 + + + Scandinavian journal of pain + Scand J Pain + + Parameters of anger as related to sensory-affective components of pain. + 10.1515/sjpain-2022-0131 + + Comorbid with chronic pain are negative emotions, anger being particularly salient. To evaluate specific relationships between pain and anger, the present study deconstructed anger into five parameters and dichotomized pain into sensory vs. affective components. Hypotheses were (i) anger parameters would be significantly and positively correlated with affective pain more so than with sensory pain, and (ii) individual parameters would be differentially related to pain components. + The Anger Parameters Scale (APS) was used to rate five parameters of anger: frequency, duration, intensity, latency, and threshold. Also rated was the physical sensation of pain and the degree of distress from pain. The volunteer sample comprised n=51 chronic pain patients, varying in ethnicity/race and educational level. + Descriptive statistics revealed: APS total M=71.52, SD=16.68, Sensory pain M=6.27, SD=2.15, Affective pain M=5.76, SD=2.28. Sensory and affective pain were highly correlated, r=0.70. APS total was significantly associated with affective pain (r=+0.28) but hardly with sensory pain (r=0.12). Two anger parameters significantly correlated with affective pain: anger frequency (r=+0.30, p<0.05) and anger threshold (r=+0.33, p<0.05). Secondarily, certain educational levels (but not gender and ethnicity/race) were associated with significantly higher APS total scores. + Scores for all variables were in the mid-range. As hypothesized, anger was more strongly correlated with distress/suffering of pain than with physical sensation of pain, though both pain components were closely coupled. Specific findings regarding frequency and threshold imply that being angry often and being oversensitive to provocation are associated with greater distress in this context. In deconstructing anger and dichotomizing pain, the present study extends previous research by elaborating on what aspects of anger are most related to which components of pain. Moreover, certain educational levels with higher levels of anger may need special attention. Further research could examine if treatment of anger might lead to corresponding changes in chronic pain. + © 2022 Walter de Gruyter GmbH, Berlin/Boston. + + + + Fernandez + Ephrem + E + + Psychology Department, University of Texas San Antonio, San Antonio, TX, USA. + + + + Pham + Tuan M + TM + + University of Texas Medical Branch, Galveston, USA. + + + + Kolaparthi + Krishna + K + + University of Texas San Antonio, Institute for Health Disparities Research, San Antonio, USA. + + + + Sun + Renhao + R + + Department of Management Science & Statistics, University of Texas San Antonio, San Antonio, USA. + + + + Perez + Brandon S + BS + + University of Texas San Antonio, San Antonio, USA. + + + + Iwuala + Emmanuel C + EC + + University of Texas San Antonio, San Antonio, USA. + + + + Wu + Wenbo + W + + Department of Management Science & Statistics, University of Texas San Antonio, San Antonio, USA. + + + + Shattuck + Eric C + EC + + Institute for Health Disparities Research and Department of Public Health, University of Texas San Antonio, San Antonio, USA. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + Germany + Scand J Pain + 101520867 + 1877-8860 + + IM + + anger + chronic pain + emotional distress + emotions + pain assessments + psychology + +
+ + + + 2022 + 09 + 11 + + + 2022 + 11 + 22 + + + 2022 + 12 + 9 + 12 + 52 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36490215 + sjpain-2022-0131 + 10.1515/sjpain-2022-0131 + + + References + + Mailis, A, Tepperman, PS, Hapidou, EG. Chronic pain: evolution of clinical definitions and implications for practice. Psychol Inj Law 2020;13:412–26. https://doi.org/10.1007/s12207-020-09391-w. + + + Raja, SN, Carr, DB, Cohen, M, Finnerup, NB, Flor, H, Gibson, S, et al.. The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises. Pain 2020;161:1976–82. https://doi.org/10.1097/j.pain.0000000000001939. + + + World Health Organization. MG30.0 chronic primary pain [Internet]; 2020. Available from: https://icd.who.int/browse11/l-m/en#/http://id.who.int/icd/entity/1326332835. + + + Fernandez, E. Anxiety, depression, and anger in pain: research findings and clinical options. Dallas, TX: Advanced Psychological Resources; 2002. + + + Fernandez, E, Turk, DC. The scope and significance of anger in the experience of chronic pain. Pain 1995;61:165–75. https://doi.org/10.1016/0304-3959(95)00192-U. + + + HannaWatts, JA. Gunman who killed 4 at Oklahoma medical building had been a patient of a victim, police chief says [Internet] CNN. Cable News Network; 2022. Available from: https://www.cnn.com/2022/06/02/us/tulsa-hospital-shooting-thursday/index.html [Accessed 6 Jun 2022]. + + + Kristjánsdóttir, G. The relationship between pains and various discomforts in schoolchildren. Childhood 1997;4:491–504. https://doi.org/10.1177/0907568297004004008. + + + Okifuji, A, Turk, DC, Curran, SL. Anger in chronic pain: investigations of anger targets and intensity. J Psychosom Res 1999;47:1–12. https://doi.org/10.1016/s0022-3999(99)00006-9. + + + Greenwood, KA, Thurston, R, Rumble, M, Waters, SJ, Keefe, FJ. Anger and persistent pain: current status and future directions. Pain 2003;103:1–5. https://doi.org/10.1016/s0304-3959(03)00132-5. + + + Adachi, T, Yamada, K, Fujino, H, Enomoto, K, Shibata, M. Associations between anger and chronic primary pain: a systematic review and meta-analysis. Scand J Pain 2021;22:1–13. https://doi.org/10.1515/sjpain-2021-0154. + + + Spielberger, CD. STAXI-2: state-trait anger expression inventory-2. Odessa, Flor: Psychological Assessment Resources; 1999. + + + Fernandez, E, Day, A, Boyle, GJ. Measures of anger and hostility in adults. In: Boyle, GJ, Saklofske, D, Matthews, G, editors. Measures of Personality and Social Psychological Constructs. London, UK: Academic Press; 2015:74–100 pp. + + + Sommer, I, Lukic, N, Rössler, W, Ettlin, DA. Measuring anger in patients experiencing chronic pain - a systematic review. J Psychosom Res 2019;125:109778. https://doi.org/10.1016/j.jpsychores.2019.109778. + + + Fernandez, E, Arevalo, I, Vargas, R, Torralba, A. Norms for five parameters of anger: how do incarcerated adults differ from the community? Int J Forensic Ment Health 2014;13:18–24. https://doi.org/10.1080/14999013.2014.889256. + + + Fernandez, E, Woldgabreal, Y, Guharajan, D, Day, A, Kiageri, V, Ramtahal, N. Social desirability bias against admitting anger: bias in the test-taker or bias in the test? J Pers Assess 2019;101:644–52. https://doi.org/10.1080/00223891.2018.1464017. + + + Henderson, MM. The anger parameters scale and the anger expressions scale: a psychometric study (Order No. 10108503). San Antonio, TX: The University of Texas at San Antonio ProQuest Dissertations Publishing; 2016. + + + Gracely, RH. Affective dimensions of pain how many and how measured? APS J 1992;1:243–7. https://doi.org/10.1016/1058-9139(92)90056-I. + + + Price, DD, Harkins, SW, Baker, C. Sensory-affective relationships among different types of clinical and experimental pain. 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+ + + 36490221 + + 2022 + 12 + 09 + +
+ + 1095-8355 + + + 2022 + Dec + 09 + + + Cell biology international + Cell Biol Int + + Spatio-temporal metabolokinetics and therapeutic effect of CD106+ mesenchymal stem/stromal cells upon mice with acute lung injury. + 10.1002/cbin.11976 + + Longitudinal investigations have revealed the unique attributes of mesenchymal stem/stromal cells (MSCs) in regenerative medicine. However, the spatio-temporal metabolokinetics and efficacy of MSCs with vascular cell adhesion molecule 1 (also known as CD106) expression in phenotypes and therapeutic effect upon acute lung injury (ALI) mice are largely obscure. For the purpose, we took advantage of the "3IL"-based strategy and Lentivirus-mediated green fluorescent protein (GFP) delivery for the generation of the CD106+ subset (denote as CD106+ -MSCs) from umbilical cord-derived MSCs (denote as NT-MSCs). Therewith, the cellular phenotypes of CD106+ -MSCs including immunophenotypes, multilineage differentiation potential towards adipocytes and osteoblasts were confirmed by flow cytometry and qRT-PCR assay. Meanwhile, multifaceted characteristics of transcriptomic features were analyzed by utilizing the RNA-SEQ and bioinformatics. Furthermore, to compare the therapeutic effects and spatio-temporal dynamics of CD106+ -MSCs, we conducted in vivo fluorescent tracer, hematoxylin and eosin staining, blood smear, blood routine and cytokine detection in mice. Herein, we generated CD106+ -MSCs with GFP expression and confirmed the conservative property of phenotypes. Compared to NT-MSCs with minimal CD106 expression, CD106+ -MSCs manifested consistent distribution and metabolokinetics in vivo but with preferable ameliorative effect upon the pathological appearance and proinflammatory cytokine secretion in ALI mice. Collectively, our data indicated the preferable therapeutic effects of CD106+ -MSCs upon ALI mice, which would benefit the further exploration of the CD106+ subset for pulmonary diseases and investigational new drug application purposes. + © 2022 International Federation for Cell Biology. + + + + Zhang + Leisheng + L + https://orcid.org/0000-0001-6540-0943 + + School of Medicine, Nankai University, Tianjin, China. + + + Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu Province & NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor, Gansu Provincial Hospital, Lanzhou, China. + + + Center for Cellular Therapies, The First Affiliated Hospital of Shandong First Medical University, Ji-nan, China. + + + Key Laboratory of Radiation Technology and Biophysics, Hefei Institute of Physical Science, Chinese Academy of Sciences, Hefei, China. + + + + Zhuo + Yi + Y + + Department of Thoracic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China. + + + + Yu + Hao + H + + School of Medicine, Nankai University, Tianjin, China. + + + National Engineering Research Center of Cell Products, AmCellGene Engineering Co., Ltd, Tianjin, China. + + + Tianjin Key Laboratory of Engineering Technologies for Cell Pharmaceutical, Tianjin, China. + + + + eng + + + 20212BAB216073 + Natural Science Foundation of Jiangxi Province + + + + 82260031 + National Natural Science Foundation of China + + + + 2021GGB007 + Young and Middle-aged Talents Training Project of Fujian Health Science and Technology Plan + + + + ZR2020QC097 + project Youth Fund supported by Shandong Provincial Natural Science Foundation + + + + QKH-J-ZK[2021]-107 + Science and Technology Projects of Guizhou Province + + + + 2022J01266 + Natural Science Foundation of Fujian Province + + + + 2021Y9083 + Science and Technology Innovation joint Fund project of Fujian Province + + + + + Journal Article + + + 2022 + 12 + 09 + +
+ + England + Cell Biol Int + 9307129 + 1065-6995 + + IM + + ALI + CD106+-MSCs + cellular phenotypes + in vivo fluorescent tracer + transcriptome analyses + +
+ + + + 2022 + 09 + 12 + + + 2022 + 01 + 22 + + + 2022 + 11 + 29 + + + 2022 + 12 + 9 + 13 + 3 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36490221 + 10.1002/cbin.11976 + + + REFERENCES + + Aitong, W., Leisheng, Z., & Hao, Y. (2021). Visualized analyses of investigations upon mesenchymal stem/stromal cell-based cytotherapy and underlying mechanisms for COVID-19 associated ARDS. Current Stem Cell Research & Therapy, 17(1), 2-12. + + + Battula, V. L., Treml, S., Bareiss, P. M., Gieseke, F., Roelofs, H., de Zwart, P., Muller, I., Schewe, B., Skutella, T., Fibbe, W. E., Kanz, L., & Buhring, H. J. (2009). Isolation of functionally distinct mesenchymal stem cell subsets using antibodies against CD56, CD271, and mesenchymal stem cell antigen-1. Haematologica, 94, 173-184. + + + Carvello, M., Lightner, A., Yamamoto, T., Kotze, P. G., & Spinelli, A. (2019). Mesenchymal stem cells for perianal crohn's disease. Cells, 8, 764. + + + Costa, L. 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JNKi- and DAC-programmed mesenchymal stem/stromal cells from hESCs facilitate hematopoiesis and alleviate hind limb ischemia. Stem Cell Research & Therapy, 10, 186. + + + Wei, Y., Zhang, L., Chi, Y., Ren, X., Gao, Y., Song, B., Li, C., Han, Z., Zhang, L., & Han, Z. (2020). High-efficient generation of VCAM-1(+) mesenchymal stem cells with multidimensional superiorities in signatures and efficacy on aplastic anaemia mice. Cell Proliferation, 53, e12862. + + + Xiao, K., He, W., Guan, W., Hou, F., Yan, P., Xu, J., Zhou, T., Liu, Y., & Xie, L. (2020). Mesenchymal stem cells reverse EMT process through blocking the activation of NF-κB and Hedgehog pathways in LPS-induced acute lung injury. Cell Death & Disease, 11, 863. + + + Xu, W., He, H., Pan, S., Chen, Y., Zhang, M., Zhu, S., Gao, Z., Peng, L., & Li, J. (2019). Combination treatments of plasma exchange and umbilical cord-derived mesenchymal stem cell transplantation for patients with hepatitis B virus-related acute-on-Chronic liver failure: A clinical trial in China. Stem Cells International, 2019, 1-10. + + + Yao, J., Chen, N., Wang, X., Zhang, L., Huo, J., Chi, Y., Li, Z., & Han, Z. (2020). Human supernumerary teeth-derived apical papillary stem cells possess preferable characteristics and efficacy on hepatic fibrosis in mice. Stem Cells International, 2020, 1-12. + + + Ye, C., Li, H., Bao, M., Zhuo, R., Jiang, G., & Wang, W. (2020). Alveolar macrophage-Derived exosomes modulate severity and outcome of acute lung injury. Aging, 12, 6120-6128. + + + Zhang, L., Chi, Y., Wei, Y., Zhang, W., Wang, F., Zhang, L., Zou, L., Song, B., Zhao, X., & Han, Z. (2021a). Bone marrow-derived mesenchymal stem/stromal cells in patients with acute myeloid leukemia reveal transcriptome alterations and deficiency in cellular vitality. 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Therapeutic prospects of mesenchymal stem/stromal cells in COVID-19 associated pulmonary diseases: From bench to bedside. World Journal of Stem Cells, 13, 1058-71. + + + Zhang, W., Liu, C., Wu, D., Liang, C., Zhang, L., Zhang, Q., Liu, Y., Xia, M., Wang, H., Su, P., Feng, S., Han, M., Zhou, J., Wang, F., & Jiang, E. (2019). Decitabine improves platelet recovery by down-regulating IL-8 level in MDS/AML patients with thrombocytopenia. Blood Cells, Molecules, and Diseases, 76, 66-71. + + + Zhao, M., Liu, S., Wang, C., Wang, Y., Wan, M., Liu, F., Gong, M., Yuan, Y., Chen, Y., Cheng, J., Lu, Y., & Liu, J. (2021). Mesenchymal stem cell-derived extracellular vesicles attenuate mitochondrial damage and inflammation by stabilizing mitochondrial DNA. ACS Nano, 15, 1519-38. + + + Zhao, Q., Zhang, L., Wei, Y., Yu, H., Zou, L., Huo, J., Yang, H., Song, B., Wei, T., Wu, D., Zhang, W., Zhang, L., Liu, D., Li, Z., Chi, Y., Han, Z., & Han, Z. (2019). Systematic comparison of hUC-MSCs at various passages reveals the variations of signatures and therapeutic effect on acute graft-versus-host disease. Stem Cell Research & Therapy, 10, 354. + + + +
+ + + 36490222 + + 2022 + 12 + 09 + +
+ + 1557-4679 + + + 2022 + Dec + 09 + + + The international journal of biostatistics + Int J Biostat + + Bayesianism from a philosophical perspective and its application to medicine. + 10.1515/ijb-2022-0043 + + Bayesian philosophy and Bayesian statistics have diverged in recent years, because Bayesian philosophers have become more interested in philosophical problems other than the foundations of statistics and Bayesian statisticians have become less concerned with philosophical foundations. One way in which this divergence manifests itself is through the use of direct inference principles: Bayesian philosophers routinely advocate principles that require calibration of degrees of belief to available non-epistemic probabilities, while Bayesian statisticians rarely invoke such principles. As I explain, however, the standard Bayesian framework cannot coherently employ direct inference principles. Direct inference requires a shift towards a non-standard Bayesian framework, which further increases the gap between Bayesian philosophy and Bayesian statistics. This divergence does not preclude the application of Bayesian philosophical methods to real-world problems. Data consolidation is a key challenge for present-day systems medicine and other systems sciences. I show that data consolidation requires direct inference and that the non-standard Bayesian methods outlined here are well suited to this task. + © 2022 the author(s), published by De Gruyter, Berlin/Boston. + + + + Williamson + Jon + J + https://orcid.org/0000-0003-0514-4209 + + Department of Philosophy and Centre for Reasoning, University of Kent, Canterbury, UK. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + Germany + Int J Biostat + 101313850 + 1557-4679 + + IM + + Bayesian networks + Bayesianism + direct inference + formal epistemology + objective Bayesianism + systems medicine + +
+ + + + 2022 + 04 + 06 + + + 2022 + 10 + 03 + + + 2022 + 12 + 9 + 13 + 12 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36490222 + ijb-2022-0043 + 10.1515/ijb-2022-0043 + + + References + + Good, IJ. Good thinking: the foundations of probability and its applications. Minneapolis: University of Minnesota Press; 1983. + + + Mayo, DG. Statistical inference as severe testing: how to get beyond the statistics wars. Cambridge: Cambridge University Press; 2018. + + + Lenhard, J. A transformation of Bayesian statistics: computation, prediction, and rationality. Stud Hist Philos Sci 2022;92:144–51. https://doi.org/10.1016/j.shpsa.2022.01.017. + + + Kass, RE. Statistical inference: the big picture. Stat Sci 2011;26:1–9. https://doi.org/10.1214/10-sts337. + + + Bovens, L, Hartmann, S. Bayesian epistemology. Oxford: Oxford University Press; 2003. + + + Olsson, EJ. Bayesian epistemology. In: Hansson, SO, Hendricks, VF, editors. Introduction to formal philosophy. 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Systems biology and emerging technologies will catalyze the transition from reactive medicine to predictive, personalized, preventive and participatory (P4) medicine. Interdiscipl Bio Cent 2009;1:1–5. https://doi.org/10.4051/ibc.2009.2.0006. + + + Carusi, A. Validation and variability: dual challenges on the path from systems biology to systems medicine. Stud Hist Philos Sci C Stud Hist Philos Biol Biomed Sci 2014;48:28–37. https://doi.org/10.1016/j.shpsc.2014.08.008. + + + Williamson, J. Models in systems medicine. Disputatio 2017;9:429–69. https://doi.org/10.1515/disp-2017-0014. + + + D’Ozario, M, Di Zio, M, Scanu, M. Statistical matching: theory and practice. Chichester: Wiley; 2006. + + + Williamson, J. Objective bayesian nets. In: Artemov, S, Barringer, H, d’Avila Garcez, AS, Lamb, LC, Woods, J, editors. We will show hem! Essays in honour of Dov Gabbay, vol 2. London: College Publications; 2005:713–30 pp. + + + Landes, J, Williamson, J. Objective Bayesian nets from consistent datasets. In: Giffin, A, Knuth, KH, editors. Proceedings of the 35th international workshop on Bayesian inference and maximum entropy methods in science and engineering. Volume 1757 of American institute of physics conference proceedings. Potsdam, NY; 2016. + + + Landes, J, Williamson, J. Objective Bayesian Nets for integrating consistent datasets. J Artif Intell Res 2022;74:393–458. https://doi.org/10.1613/jair.1.13363. + + + Nagl, S, Williams, M, Williamson, J. Objective Bayesian nets for systems modelling and prognosis in breast cancer. In: Holmes, D, Jain, L, editors. Innovations in Bayesian networks: theory and applications. Berlin: Springer; 2008:131–67 pp. + + + Fridlyand, J, Snijders, A, Ylstra, B, Li, H, Olshen, A, Segraves, R, et al.. Breast tumor copy number aberration phenotypes and genomic instability. BMC Cancer 2006;6:96. https://doi.org/10.1186/1471-2407-6-96. + + + Endres, E, Augustin, T. Statistical matching of discrete data by Bayesian networks. In: Antonucci, A, Corani, G, Campos, CP, editors. Proceedings of the eighth international conference on probabilistic graphical models, vol 52; 2016:159–70 pp. Proceedings of Machine Learning Research. + + + Datta, GS, Sweeting, TJ. Probability matching priors. In: Dey, DK, Rao, CR, editors. Bayesian thinking: modeling and computation. Handbook of statistics 25. Amsterdam: Elsevier; 2005:91–114 pp. + + + Scricciolo, C. Probability matching priors: a review. J Ital Stat Soc 1999;8:83–100. https://doi.org/10.1007/bf03178943. + + + Dawid, AP. The well-calibrated Bayesian. J Am Stat Assoc 1982;77:604–13. https://doi.org/10.1080/01621459.1982.10477856. + + + Howson, C, Urbach, P. Scientific reasoning: the Bayesian approach. In: Open Court, 2nd ed. Chicago IL; 1989. + + + Price, KL, Xia, HA, Lakshminarayanan, M, Madigan, D, Manner, D, Scott, J, et al.. Bayesian methods for design and analysis of safety trials. Pharmaceut Stat 2014;13:13–24. https://doi.org/10.1002/pst.1586. + + + De Pretis, F, Landes, J, Osimani, B. E-synthesis: a Bayesian framework for causal assessment in pharmacosurveillance. Front Pharmacol 2019;10:1317. https://doi.org/10.3389/fphar.2019.01317. + + + De Pretis, F, Landes, J, Peden, W. Artificial intelligence methods for a Bayesian epistemology-powered evidence evaluation. J Eval Clin Pract 2021;27:504–12. https://doi.org/10.1111/jep.13542. + + + Chang, H. Is water H2O? Evidence, realism and pluralism. In: Boston studies in the philosophy of science. Dordrecht: Springer; 2012. + + + Ludwig, D, Ruphy, S. Scientific pluralism. In: Zalta, EN, editor. The Stanford encyclopedia of philosophy. Metaphysics Research Lab. Stanford University; 2021. + + + Gillies, D, Zheng, Y. Dynamic interactions with the philosophy of mathematics. Theoria 2001;16:437–59. + + + +
+ + + 36490227 + + 2022 + 12 + 09 + +
+ + 1748-3115 + + + 2022 + Dec + 09 + + + Disability and rehabilitation. Assistive technology + Disabil Rehabil Assist Technol + + Informing the development of a mobile application for the physical activity guidelines in multiple sclerosis: a qualitative, pluralistic approach. + + 1-9 + + 10.1080/17483107.2022.2153937 + + The uptake of Physical Activity Guidelines (PAGs) for adults with multiple sclerosis (MS) may be facilitated through mHealth solutions such as a mobile app. To date, there is limited information regarding preferred features of an app for people with MS. We explored desired features for an app that supports physical activity behaviour among persons with MS. + Using a pluralistic analytical approach, we conducted a secondary qualitative analysis on a portion of data collected from an earlier study to explore (i) what persons with MS wanted in an app based on the PAGs and (ii) how the PAG-based app should facilitate behaviour change. The data were subjected to deductive, content analysis to identify populous mentions of desired PAG-based app elements. We then used inductive, semantic reflexive thematic analysis to further explore the opinions and evaluations of participants. + Participants (n = 16) perceived features such as activity tracking, incentives for completing milestones, and customization as both triggers for doing PA and supporting engagement with the app. Participants desired a personalized PA prescription based on mobility and fitness level, expert feedback based on data entered in the app, and an exercise library with a range of evidence-based content. Participants insisted the app be backed by a solid scientific foundation and that accessibility of personal data be controlled by the user. + This study identifies several design considerations for an app based on the PAGs. The results suggest a simple, trustworthy, and evidence-based app that focuses on helping persons with MS reach the PAGs. + + + + Neal + Whitney N + WN + 0000-0002-8019-3759 + + Department of Health Behavior, University of Alabama, Birmingham, AL, USA. + + + + Richardson + Emma V + EV + + School of Sport and Exercise, University of Worchester, Worchester, UK. + + + + Motl + Robert W + RW + + Department of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL, USA. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + England + Disabil Rehabil Assist Technol + 101255937 + 1748-3107 + + IM + + mHealth technologies could be an empowering and inclusive method of supporting physical activity uptake among persons with multiple sclerosis (MS).Knowledge is currently lacking regarding how mHealth technologies, such as mobile apps, can facilitate uptake of Physical Activity Guidelines for Adults with MS (PAGs).People with MS (N = 16) desired an app grounded in a solid scientific foundation, but then translated into simple, accessible, personalized physical activity guidelines that focused on achieving activity goals.Motivational, functional, and personalization strategies should be included in the development of an app based on the PAGs. + + + Exercise + health promotion + qualitative inquiry + telehealth + +
+ + + + 2022 + 12 + 9 + 13 + 13 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36490227 + 10.1080/17483107.2022.2153937 + + +
+ + + 36490229 + + 2022 + 12 + 09 + +
+ + 1522-726X + + + 2022 + Dec + 09 + + + Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions + Catheter Cardiovasc Interv + + Short-term dual antiplatelet therapy for 1-3 months after percutaneous coronary intervention using drug eluting stents: A systematic review and meta-analysis of randomized clinical trials. + 10.1002/ccd.30521 + + The optimal dual antiplatelet therapy (DAPT) duration and regimen in patients undergoing percutaneous coronary intervention (PCI) using current generation drug eluting stents (DES) is still unclear. + To compare the safety and efficacy of short-term DAPT (S-DAPT) with longer duration DAPT (l-DAPT) after contemporary PCI. + We searched for studies comparing S-DAPT (≤3 months) followed by single antiplatelet therapy (SAPT) with aspirin or a P2Y12 inhibitor against L-DAPT (6-12 months) after PCI with current generation DES. Primary end-points of interest were major bleeding and stent thrombosis (ST) at 1 year. Random-effects meta-analyses were performed to calculate odds ratios with 95% CIs. + Eleven RCTs (n = 48,946) were included in the primary analysis. Major bleeding was significantly lower with S-DAPT (n = 24,424) (odd ratio [OR 0.65; 95% confidence interval, CI 0.52-0.80]) compared with L-DAPT (n = 24,486). There were no differences in ST between the two groups [OR 1.26; 95% CI 0.97-1.63]. There were no significant differences in risks of all-cause death, cardiovascular death or myocardial infarction between S-DAPT and L-DAPT groups. In a subgroup analysis, there was borderline significantly higher ST with 1 month S-DAPT [1.39; 1.0-1.92], but not with 3 months S-DAPT [1.07; 0.70-1.64], when compared to L-DAPT. Finally, there were no significant treatment interactions observed when trials using SAPT with aspirin were compared with those using P2Y12 inhibitor monotherapy. + Among patients undergoing current generation DES implantation, S-DAPT for 1-3 months reduces major bleeding without an increase in ischemic events compared with L-DAPT. Three months S-DAPT might provide a better risk-benefit profile based on current analysis. Further study is needed to define the SAPT of choice after 1-3 months DAPT. + © 2022 Wiley Periodicals LLC. + + + + Rout + Amit + A + http://orcid.org/0000-0002-0911-240X + + Division of Cardiology, University of Louisville, Kentucky, USA. + + + + Sharma + Abhishek + A + https://orcid.org/0000-0003-3480-5440 + + Division of Cardiology, Rutgers New Jersey Medical School, New Jersey, USA. + + + + Ikram + Sohail + S + + Division of Cardiology, University of Louisville, Kentucky, USA. + + + + Garg + Aakash + A + http://orcid.org/0000-0003-0126-0851 + + Division of Cardiology, Ellis Hospital, New York, USA. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + Catheter Cardiovasc Interv + 100884139 + 1522-1946 + + IM + + P2Y12 inhibitor + aspirin + drug eluting stents + dual antiplatelet therapy + percutaneous coronary intervention + +
+ + + + 2022 + 07 + 31 + + + 2022 + 11 + 20 + + + 2022 + 12 + 9 + 13 + 22 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36490229 + 10.1002/ccd.30521 + + + REFERENCES + + Levine GN, Bates ER, Bittl JA, et al. 2016 ACC/AHA guideline focused update on duration of dual antiplatelet therapy in patients with coronary artery disease: a report of the American college of Cardiology/American heart association task force on clinical practice guidelines. J Am Coll Cardiol. 2016;(68):1082-1115. + + + Valgimigli M, Bueno H, Byrne RA, et al. ESC scientific document group 2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS: the task force for dual antiplatelet therapy in coronary artery disease of the european society of cardiology (ESC) and of the european association for Cardio-Thoracic surgery (EACTS). Eur Heart J. 2018;39:213-260. + + + Mauri L, Kereiakes DJ, Yeh RW, et al. Twelve or 30 months of dual antiplatelet therapy after drug-eluting stents. N Engl J Med. 2014;371:2155-2166. + + + Kim BK, Hong MK, Shin DH, et al. A new strategy for discontinuation of dual antiplatelet therapy. J Am Coll Cardiol. 2012;60:1340-1348. + + + Feres F, Costa RA, Abizaid A, et al. Three vs twelve months of dual antiplatelet therapy after zotarolimus-eluting stents: the OPTIMIZE randomized trial. JAMA. 2013;310:2510-2522. + + + De Luca G, Damen SA, Camaro C, Collaborators Final results of the randomised evaluation of short-term dual antiplatelet therapy in patients with acute coronary syndrome treated with a new-generation stent (REDUCE trial). EuroIntervention. 2019;Dec 6 15(11):e990-e998. + + + Mehran R, Baber U, Sharma SK, et al. Ticagrelor with or without aspirin in high-risk patients after PCI. N Engl J Med. 2019;381:2032-2042. + + + Vranckx P, Valgimigli M, Jüni P, et al. Ticagrelor plus aspirin for 1 month, followed by ticagrelor monotherapy for 23 months vs aspirin plus clopidogrel or ticagrelor for 12 months, followed by aspirin monotherapy for 12 months after implantation of a drug-eluting stent: a multicentre, open-label, randomised superiority trial. Lancet (London, England). 2018;392:940-949. + + + Moher D, Shamseer L, Clarke M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. 2015;4:1. + + + Hahn JY, Song YB, Oh JH, et al. Effect of P2Y12 inhibitor monotherapy vs dual antiplatelet therapy on cardiovascular events in patients undergoing percutaneous coronary intervention: the SMART-CHOICE randomized clinical trial. JAMA. 2019;321:2428-2437. + + + Watanabe H, Domei T, Morimoto T, et al. Effect of 1-Month dual antiplatelet therapy followed by clopidogrel vs. 12-month dual antiplatelet therapy on cardiovascular and bleeding events in patients receiving PCI: the STOPDAPT-2 randomized clinical trial. JAMA. 2019;321:2414-2427. + + + Presented by Watanabe H, Short and Optimal Duration of Dual Antiplatelet Therapy After Everolimus-Eluting Cobalt-Chromium Stent-2 Acute Coronary Syndrome-STOPDAPT-2 ACS. European Society of Cardiology Virtual Congress. 2021. + + + Kim BK, Hong SJ, Cho YH, et al. Effect of ticagrelor monotherapy vs ticagrelor with aspirin on major bleeding and cardiovascular events in patients with acute coronary syndrome: the TICO randomized clinical trial. JAMA. 2020;323(23):2407-2416. + + + Smits PC, Frigoli E, Tijssen J, et al. MASTER DAPT investigators. abbreviated antiplatelet therapy in patients at high bleeding risk with or without oral anticoagulant therapy after coronary stenting: an Open-Label, randomized, controlled trial. Circulation. 2021;144:1196-1211. + + + Hong SJ, Kim JS, Hong SJ, et al. 1-Month Dual-Antiplatelet therapy followed by aspirin monotherapy after polymer-free drug-coated stent implantation: one-month DAPT trial. JACC. Cardiovasc interv. 2021;14(16):1801-1811. + + + Gwon HC, Hahn JY, Park KW, et al. Six-month versus 12-month dual antiplatelet therapy after implantation of drug-eluting stents: the efficacy of Xience/Promus versus cypher to reduce late loss after stenting (EXCELLENT) randomized, multicenter study. Circulation. 2012;125:505-513. + + + Schulz-Schüpke S, Byrne RA, Ten Berg JM, et al. ISAR-SAFE: a randomized, double-blind, placebo-controlled trial of 6 vs. 12 months of clopidogrel therapy after drug-eluting stenting. Eur Heart J. 2015;36:1252-1263. + + + Sharma A, Agrawal S, Garg A, Vallakati A, Lavie CJ, Helft G. Duration of dual antiplatelet therapy following drug-eluting stent implantation: a systemic review and meta-analysis of randomized controlled trials with longer follow up. Catheter Cardiovasc Interv. 2017;90:31-37. + + + Capodanno D, Mehran R, Valgimigli M, et al. Aspirin-free strategies in cardiovascular disease and cardioembolic stroke prevention. Nat Rev Cardiol. 2018;15(8):480-496. + + + Garg A, Rout A, Sharma A, et al. Safety and efficacy of antiplatelet regimens after percutaneous coronary intervention using drug eluting stents: a network meta-analysis of randomized controlled trials. Prog Cardiovasc Dis. 2020;63(3):243-248. + + + Kuramitsu S, Ohya M, Shinozaki T, et al. Risk factors and long-term clinical outcomes of second-generation drug-eluting stent thrombosis. Circulation: Cardiovasc Interv. 2019;12(6):e007822. + + + Giacoppo D, Matsuda Y, Fovino LN, et al. Short dual antiplatelet therapy followed by P2Y12 inhibitor monotherapy vs. prolonged dual antiplatelet therapy after percutaneous coronary intervention with second-generation drug-eluting stents: a systematic review and meta-analysis of randomized clinical trials. Eur Heart J. 2021;42(4):308-319. + + + Collet JP, Thiele H, Barbato E, et al. 2020 ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Eur Heart J. 2021;42(14):1289-1367. + + + Costa F, Van Klaveren D, Feres F, et al. Dual antiplatelet therapy duration based on ischemic and bleeding risks after coronary stenting. J Am Coll Cardiol. 2019;73(7):741-754. + + + Valgimigli M, Gragnano F, Branca M, et al. P2Y12 inhibitor monotherapy or dual antiplatelet therapy after coronary revascularisation: individual patient level meta-analysis of randomised controlled trials. BMJ. 2021;373:n1332. doi:10.1136/bmj.n1332 + + + Koo BK, Kang J, Park KW, et al. Aspirin versus clopidogrel for chronic maintenance monotherapy after percutaneous coronary intervention (HOST-EXAM): an investigator-initiated, prospective, randomised, open-label, multicentre trial. Lancet. 2021;397(10293):2487-2496. + + + +
+ + + 36490230 + + 2022 + 12 + 09 + +
+ + 1522-726X + + + 2022 + Dec + 09 + + + Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions + Catheter Cardiovasc Interv + + Comparison of radiation exposure associated with transradial and transfemoral access: An updated meta-analysis. + 10.1002/ccd.30513 + + To assess differences in radiation exposure between transradial access (TRA) and transfemoral access (TFA) for coronary procedures. + TRA is associated with increased radiation exposure as compared to TFA. We compared radiation exposure between the two access sites. + Databases were searched from June 2014 to August 2021 for randomized controlled trials (RCTs) reporting coprimary outcomes of fluoroscopy time (FT) and/or dose area product (DAP) comparing TRA with TFA. Meta-regression was performed to assess the behavior of weighted mean difference (WMD) in FT from 1995 to 2021. Observational study data was used for corroborative evidence. + Data from 8 RCTs (11,611 patients) showed the WMD of FT was 0.62 min (37 s) (95% confidence interval [CI]: [0.08-1.17], p = 0.023) in favor of TFA, WMD in DAP (9169 patients) was 1.94 Gy.cm2 (95% CI: [-2.1 to 5.9], p = 0.35) showing no significant difference. Pooled data from OBS and RCTs (83,990 patients) showed a similar trend. Studies from outside US between 1995 and 2021 showed WMD of FT between TRA and TFA of 0.88 min (52 s) (95% CI: [0.67-1.09], p = 0.005) versus 2.1 min (126 s) (95% CI: [1.38-2.8], p = 0.005) for US in favor of TFA. Meta-regression showed a declining WMD of FT between TRA and TFA from 1.6 min (96 s) in 1996 to 0.5 min (30 s) in 2020 with the lower limit of CI crossing the zero line in 2019. + Radiation exposure between TRA and TFA continues to decrease overtime and is becoming clinically nonsignificant. + © 2022 Wiley Periodicals LLC. + + + + Saqib + Najam + N + + The Wright Center for Graduate Medical Education, Scranton, Pennsylvania, USA. + + + + Pir + Muhammad S + MS + http://orcid.org/0000-0003-2750-2134 + + The Wright Center for Graduate Medical Education, Scranton, Pennsylvania, USA. + + + + Rajagopalan + Sharath + S + + The Wright Center for Graduate Medical Education, Scranton, Pennsylvania, USA. + + + + Patel + Tejas M + TM + http://orcid.org/0000-0001-9433-6493 + + Apex Heart Institute, Ahmedabad, India. + + + + Pancholy + Samir B + SB + http://orcid.org/0000-0001-7831-0699 + + The Wright Center for Graduate Medical Education, Scranton, Pennsylvania, USA. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + Catheter Cardiovasc Interv + 100884139 + 1522-1946 + + IM + + cardiac catheterization + radiation exposure + transradial access + +
+ + + + 2022 + 11 + 01 + + + 2022 + 03 + 04 + + + 2022 + 11 + 23 + + + 2022 + 12 + 9 + 13 + 22 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36490230 + 10.1002/ccd.30513 + + + REFERENCES + + Feldman DN, Swaminathan RV, Kaltenbach LA, et al. Adoption of radial access and comparison of outcomes to femoral access in percutaneous coronary intervention: an updated report from the national cardiovascular data registry (2007−2012). Circulation. 2013;127:2295-2306. + + + Bertrand OF, Bélisle P, Joyal D, et al. Comparison of transradial and femoral approaches for percutaneous coronary interventions: a systematic review and hierarchical Bayesian meta-analysis. Am Heart J. 2012;163:632-648. + + + Amin AP, House JA, Safley DM, et al. Costs of transradial percutaneous coronary intervention. JACC: Cardiovasc Interv. 2013;6:827-834. + + + Cooper CJ, El-Shiekh RA, Cohen DJ, et al. Effect of transradial access on quality of life and cost of cardiac catheterization: a randomized comparison. Am Heart J. 1999;138:430-436. + + + Rao SV, Hess CN, Barham B, et al. A registry-based randomized trial comparing radial and femoral approaches in women undergoing percutaneous coronary intervention. JACC: Cardiovasc Interv. 2014;7:857-867. + + + Romagnoli E, Biondi-Zoccai G, Sciahbasi A, et al. Radial versus femoral randomized investigation in ST-segment elevation acute coronary syndrome. J Am Coll Cardiol. 2012;60:2481-2489. + + + Rao SV, Tremmel JA, Gilchrist IC, et al. Best practices for transradial angiography and intervention: a consensus statement from the society for cardiovascular angiography and intervention's transradial working group. Catheter Cardiovasc Interv. 2014;83:228-236. + + + Lange HW, von Boetticher H. Randomized comparison of operator radiation exposure during coronary angiography and intervention by radial or femoral approach. Catheter Cardiovasc Interv. 2006;67:12-16. + + + Pancholy SB, Joshi P, Shah S, Rao SV, Bertrand OF, Patel TM. Effect of vascular access site choice on radiation exposure during coronary angiography. JACC: Cardiovasc Interv. 2015;8:1189-1196. + + + Lo TS, Ratib K, Chong AY, Bhatia G, Gunning M, Nolan J. Impact of access site selection and operator expertise on radiation exposure; a controlled prospective study. Am Heart J. 2012;164:455-461. + + + Plourde G, Pancholy SB, Nolan J, et al. Radiation exposure in relation to the arterial access site used for diagnostic coronary angiography and percutaneous coronary intervention: a systematic review and meta-analysis. Lancet. 2015;386:2192-2203. + + + Higgins JPT, Altman DG, Gotzsche PC, et al. The Cochrane collaboration's tool for assessing risk of bias in randomised trials. BMJ. 2011;343:d5928. + + + Wells G, Shea B, O'Connell D, et al. Newcastle-Ottawa quality assessment scale cohort studies University of Ottawa. 2014. + + + Hozo SP, Djulbegovic B, Hozo I. Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol. 2005;5:13. + + + Higgins JP, Thomas J, Chandler J, eds. Cochrane Handbook for Systematic Reviews of Interventions. John Wiley & Sons; 2019. + + + Tarighatnia A, Mohammad Alian AH, Ghojazadeh M, Farajollahi AR. Comparison of the patient radiation exposure during coronary angiography and angioplasty procedures using trans-radial and trans-femoral access. J Cardiovasc Thorac Res. 2016;8:77-82. + + + Tarighatnia A, Mohammadalian A, Ghojazade M, Pourafkari L, Farajollahi A. Beam projections and radiation exposure in transradial and transfemoral approaches during coronary angiography. Anatolian J Cardiol. 2017;18:298. + + + Bhat FA, Changal KH, Raina H, Tramboo NA, Rather HA. Transradial versus transfemoral approach for coronary angiography and angioplasty-a prospective, randomized comparison. BMC Cardiovasc Disord. 2017;17:23. + + + Sciahbasi A, Frigoli E, Sarandrea A, et al. Radiation exposure and vascular access in acute coronary syndromes. J Am Coll Cardiol. 2017;69:2530-2537. + + + Shanmugam A. [Abstract]. TCT-556 comparison of radiation exposure in PCI between radial and femoral approach using nanoDot dosimeters on patients and direct readout Pocket mini dosimeter on operators. J Am Coll Cardiol. 2018;72:B223. + + + Schernthaner C, Hammerer M, Harb S, et al. Radial versus femoral access site for percutaneous coronary intervention in patients suffering acute myocardial infarction. Wien Klin Wochenschr. 2018;130:182-189. + + + Le May M, Wells G, So D, et al. Safety and efficacy of femoral access vs radial access in ST-segment elevation myocardial infarction: the SAFARI-STEMI randomized clinical trial. JAMA Cardiol. 2020;5:126-134. + + + Kabir CS, Haq MM, Khan SR, Chowdhury MZ, Ali ML, Karim MR. Safety of radial vs. femoral artery access in coronary angiography. Bangladesh Heart J. 2016;30:68-73. + + + Dobies DR, Barber KR, Cohoon AL. Analysis of safety outcomes for radial versus femoral access for percutaneous coronary intervention from a large clinical registry. Open Heart. 2016;3(2):e000397. + + + Habibi M, Karyofyllis P, Voudris V. [Abstract]. 0368: radiation in transfemoral versus transradial access in diagnostic coronary angiography. Arch Cardiovasc Dis. 2016;8:4. + + + Habibi M, Kollaros N, Karyofyllis P, Mastorakou I, Voudris V. Factors affecting exposure parameters during diagnostic coronary catheterization. Phys Med. 2016;32:259. + + + Cross T, Semillion E, Spiro J, Schultz C, Alcock R. Radiation dose for transfemoral and transradial access in cardiac catheterisation procedures. Heart, Lung Circ. 2016;25:S192-S193. + + + Mujtaba SF, Saghir T, Naseeb K, Akbar J, H Rizvi SN. Comparison of radiation and contrast safety between radial and femoral approaches in patients undergoing coronary catheterization. Pakistan Heart J. 2018;51(2):99-103. + + + Dai Y, Li C, Zhang F, et al. Safety and efficacy of percutaneous coronary intervention via transradial versus transfemoral approach in bypass grafts. Angiology. 2018;69(2):136-142. + + + Rychlík J, Horňáček I, Tejc M, Petrikovits E, Klimsa Z. Impact of radial and femoral access on radiation dose and fluorography time in patients with acute coronary syndrome. Cor Vasa. 2018;60:e377-e380. + + + Üreyen ÇM, Coşansu K, Vural MG, et al. Is trans-radial approach related to an increased risk of radiation exposure in patients who underwent diagnostic coronary angiography or percutaneous coronary intervention (The SAKARYA study). Anatolian J Cardiol. 2019;22:5. + + + Mujtaba SF, Saghir T, Sial JA, Rizvi NH. Procedural determinants of fluoroscopy time in patients undergoing cardiac catheterization. Pak J Med Sci. 2019;35:166. + + + Hirzallah H, Amro A, Kusmic D, et al. Comparison of transradial and transfemoral approaches for coronary angiography and percutaneous intervention in patients with coronary bypass grafts. Cardiovasc Revascularization Med. 2020;21:2-5. + + + Amro A, Mansoor K, Amro M, et al. Transradial versus transfemoral approach for coronary angiography in females with prior bypass surgery. Cureus. 2020;12(1):e6797. + + + Baklanov DV, Kaltenbach LA, Marso SP, et al. The prevalence and outcomes of transradial percutaneous coronary intervention for ST-segment elevation myocardial infarction. J Am Coll Cardiol. 2013;61:420-426. + + + +
+ + + 36490233 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Integrated survey of helminthic neglected tropical diseases and comparison of two mosquito sampling methods for lymphatic filariasis molecular xenomonitoring in the River Galana area, Kilifi County, coastal Kenya. + + e0278655 + + 10.1371/journal.pone.0278655 + + A lymphatic filariasis (LF) endemic focus along the River Galana/ Sabaki in Kilifi County, coastal Kenya, provided a platform to conduct an integrated survey for three helminthic neglected tropical diseases (NTDs), namely soil-transmitted helminthiasis (STH), schistosomiasis (SCH) and LF. Additionally, the study compared the performance of two mosquito trapping methods for LF molecular xenomonitoring (MX). Cross-sectional surveys measuring STH, SCH and LF prevalence were conducted in four villages. Mosquitoes were trapped using the CDC light trap (CDC-LT) and the Ifakara A tent trap (Ifakara-TT) methods and stored in pools which were tested for Wuchereria bancrofti DNA using the real-time polymerase chain reaction assay. A total of 907 people (436 adults; 471 children) participated in the parasitological testing. Among the STH infections, Trichuris trichiura and hookworms were most prevalent among the children and adult populations, respectively. The schistosome worm eggs detected belonged to the species Schistosoma haematobium and the prevalence of the infection was generally higher among the children compared with the adult population. The prevalence of LF infection among the adult population ranged from 1.8% to 7.6% across all 4 villages (P < 0.05). A total of 3,652 mosquitoes, including Anopheles, Culex, Mansonia, and Aedes species were collected. One mosquito pool consisting of Anopheles mosquitoes tested positive for filarial DNA out of 1,055 pools that were tested. The CDC-LT caught significantly more mosquitoes compared with the Ifakara-TT (P < 0.001). This study demonstrated that integrated epidemiological surveys using standard parasitological and entomological methods can provide useful information on co-endemic parasitic diseases which could help direct interventions and surveillance activities. + Copyright: © 2022 Njenga et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Njenga + Sammy M + SM + https://orcid.org/0000-0001-6309-476X + + Eastern and Southern Africa Centre of International Parasite Control, Kenya Medical Research Institute, Nairobi, Kenya. + + + + Kanyi + Henry M + HM + + Eastern and Southern Africa Centre of International Parasite Control, Kenya Medical Research Institute, Nairobi, Kenya. + + + + Mwatele + Cassian M + CM + + Eastern and Southern Africa Centre of International Parasite Control, Kenya Medical Research Institute, Nairobi, Kenya. + + + + Mukoko + Dunstan A + DA + + Division of Vector Borne and Neglected Tropical Diseases, Ministry of Health, Nairobi, Kenya. + + + + Bockarie + Moses J + MJ + https://orcid.org/0000-0002-4022-8603 + + School of Community Health Sciences, Njala University, Bo, Sierra Leone. + + + + Kelly-Hope + Louise A + LA + + Department of Tropical Disease Biology, Centre for Neglected Tropical Diseases, Liverpool School of Tropical Medicine, Liverpool, United Kingdom. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 04 + 08 + + + 2022 + 11 + 21 + + + 2022 + 12 + 9 + 13 + 32 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490233 + 10.1371/journal.pone.0278655 + PONE-D-22-10379 + + +
+ + + 36490225 + + 2022 + 12 + 09 + +
+ + 1940-6215 + + + 2022 + Dec + 09 + + + Cancer prevention research (Philadelphia, Pa.) + Cancer Prev Res (Phila) + + Prospective Study of Avocado Consumption and Cancer Risk in US Men and Women. + CAPR-22-0298 + 10.1158/1940-6207.CAPR-22-0298 + + Avocados contain nutrients and phytochemicals that make it promising for cancer prevention, and chemopreventive properties have been demonstrated in prior studies. Prospective studies on avocado consumption and cancer risk have yet to be conducted. This study included data from 45,289 men in the Health Professionals Follow-Up Study (HPFS, 1986-2016) and 67,039 women in the Nurses' Health Study (NHS, 1986-2014). Avocado consumption was assessed using validated food frequency questionnaires every four years. Cox proportional hazards models calculated multivariable hazard ratios (HR) and 95% confidence intervals (CI) for associations between avocado consumption and risk of total and site-specific cancers in each cohort. In HPFS, consumption of ≥1 weekly serving of avocados was associated with decreased risk of total (HR 0.85; 95% CI 0.80-0.91), colorectal (HR 0.71; 95% CI 0.59-0.85), lung (HR 0.71; 95% CI 0.57-0.90), and bladder cancer (HR 0.72; 95% CI 0.57-0.90). In NHS, avocado consumption was associated with increased risk of breast cancer (HR 1.21; 95% CI 1.07-1.37). No associations were observed between avocado consumption and risk of total cancer (HR 1.06; 95% CI 0.98-1.14) or other site-specific cancers in NHS. Considering the surprising breast cancer finding, analyses were repeated using data from 93,230 younger women in the parallel NHSII (1991-2017). In NHSII, avocado consumption was not associated with breast cancer risk (HR 0.93, 95% CI 0.76-1.13). Overall, avocado consumption may be associated with reduced risk of total and some site-specific cancers in men. The positive association with breast cancer risk in NHS was not seen in the younger NHSII. + + + + Ericsson + Caroline I + CI + 0000-0001-6732-7006 + + Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States. + + + + Pacheco + Lorena S + LS + 0000-0002-0569-9506 + + Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States. + + + + Romanos-Nanclares + Andrea + A + 0000-0002-9694-7607 + + University of Navarra, Pamplona, Navarra, Spain. + + + + Ecsedy + Ethan + E + 0000-0001-8652-9201 + + Bowdoin College, Brunswick, Maine, United States. + + + + Giovannucci + Edward L + EL + 0000-0002-6123-0219 + + Harvard T.H. Chan School of Public Health, Boston, MA, United States. + + + + Eliassen + A Heather + AH + 0000-0002-3961-6609 + + Brigham and Women's Hospital, Boston, MA, United States. + + + + Mucci + Lorelei A + LA + 0000-0002-2551-4927 + + Harvard T.H. Chan School of Public Health, Boston, MA, United States. + + + + Fu + Benjamin C + BC + 0000-0001-6195-3647 + + Harvard T.H. Chan School of Public Health, Boston, MA, United States. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + Cancer Prev Res (Phila) + 101479409 + 1940-6215 + + IM +
+ + + + 2022 + 12 + 07 + + + 2022 + 06 + 24 + + + 2022 + 10 + 09 + + + 2022 + 12 + 9 + 13 + 13 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36490225 + 711584 + 10.1158/1940-6207.CAPR-22-0298 + + +
+ + + 36490231 + + 2022 + 12 + 09 + +
+ + 1935-2735 + + 16 + 12 + + 2022 + Dec + + + PLoS neglected tropical diseases + PLoS Negl Trop Dis + + Expression of Concern: Characterization of a Subunit of the Outer Dynein Arm Docking Complex Necessary for Correct Flagellar Assembly in Leishmania donovani. + + e0010981 + + 10.1371/journal.pntd.0010981 + + + PLOS Neglected Tropical Diseases Editors + + + eng + + Journal Article + Expression of Concern + + + 2022 + 12 + 09 + +
+ + United States + PLoS Negl Trop Dis + 101291488 + 1935-2727 + + IM + + + PLoS Negl Trop Dis. 2010 Jan 26;4(1):e586 + 20126266 + + +
+ + + + 2022 + 12 + 9 + 13 + 23 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490231 + 10.1371/journal.pntd.0010981 + PNTD-D-22-01488 + + +
+ + + 36490226 + + 2022 + 12 + 09 + +
+ + 1522-726X + + + 2022 + Dec + 09 + + + Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions + Catheter Cardiovasc Interv + + Novel application of intravascular lithotripsy in stent under-expansion: A single-center experience. + 10.1002/ccd.30516 + + Stent under-expansion due to calcification is associated with a less durable result. The development of intravascular lithotripsy (IVL) has provided clinicians with a readily available, simple-to-use treatment option for coronary calcification, but the use of IVL within a previously stented segment is currently off-license. There are, however, developing data suggesting that the use of IVL can be an effective treatment option for patients with calcific stent under-expansion. + This was a single-center study of all patients treated with IVL for calcific stent under-expansion between January 2019 and June 2021. The impact of IVL on quantitative coronary angiography (QCA) stenosis and on the minimal stent area (MSA) derived from intracoronary imaging were recorded. The presence of periprocedural complications and adverse cardiovascular events was obtained from the clinical record during the study timeframe. + Thirty-nine patients underwent IVL for calcific stent under-expansion during the study time frame with one patient treated with more than one lesion in the same session. In all lesions, there was an improvement in the QCA stenosis with 37 (92.5%) having a residual stenosis of ≤30%. The mean QCA stenosis pre-IVL was 68 ± 21% and following IVL the mean QCA was 18 ± 9% (p < 0.001). In all lesions, there was an improvement in the MSA, with 26 (92.9%) achieving an MSA of more than 4.5 mm2 . The mean MSA pre-IVL was 3.88 ± 1.51 mm2 and following IVL the mean MSA was 7.41 ± 2.34 mm2 (p < 0.001). There were no major procedural complications. Over a mean follow-up of 506 ± 277 days, one patient died from ventricular arrhythmia but there were no other major adverse cardiovascular events. + This single-center study demonstrates that IVL is a safe and effective treatment for calcific stent under-expansion with good medium-term results. + © 2022 Wiley Periodicals LLC. + + + + Hinton + Jonathan + J + http://orcid.org/0000-0003-1670-5550 + + Dorset Heart Centre, Royal Bournemouth Hospital, Bournemouth, UK. + + + + Mariathas + Mark + M + + Dorset Heart Centre, Royal Bournemouth Hospital, Bournemouth, UK. + + + + Chan + Elizabeth + E + + Dorset Heart Centre, Royal Bournemouth Hospital, Bournemouth, UK. + + + + Patel + Amit + A + + Dorset Heart Centre, Royal Bournemouth Hospital, Bournemouth, UK. + + + + Singh + Satnam + S + + Dorset Heart Centre, Royal Bournemouth Hospital, Bournemouth, UK. + + + + Konstantinou + Klio + K + + Dorset Heart Centre, Royal Bournemouth Hospital, Bournemouth, UK. + + + + Din + Jehangir + J + + Dorset Heart Centre, Royal Bournemouth Hospital, Bournemouth, UK. + + + + Kodoth + Vivek + V + + Dorset Heart Centre, Royal Bournemouth Hospital, Bournemouth, UK. + + + + Levy + Terry + T + + Dorset Heart Centre, Royal Bournemouth Hospital, Bournemouth, UK. + + + + Swallow + Rosie + R + + Dorset Heart Centre, Royal Bournemouth Hospital, Bournemouth, UK. + + + + Talwar + Suneel + S + + Dorset Heart Centre, Royal Bournemouth Hospital, Bournemouth, UK. + + + + O'Kane + Peter + P + + Dorset Heart Centre, Royal Bournemouth Hospital, Bournemouth, UK. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + Catheter Cardiovasc Interv + 100884139 + 1522-1946 + + IM + + acute coronary syndrome + complex coronary revascularization + coronary calcification + drug-eluting stent + +
+ + + + 2022 + 10 + 19 + + + 2022 + 05 + 08 + + + 2022 + 11 + 19 + + + 2022 + 12 + 9 + 13 + 13 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36490226 + 10.1002/ccd.30516 + + + REFERENCES + + Guedeney P, Claessen BE, Mehran R, et al. Coronary calcification and long-term outcomes according to drug-eluting stent generation. JACC Cardiovasc Interv. 2020;13(12):1417-1428. + + + Tada T, Miura K, Ikuta A, et al. Prevalence, predictors, and outcomes of in-stent restenosis with calcified nodules. EuroIntervention. 2022;17(16):1352-1361. + + + Choi SY, Maehara A, Cristea E, et al. Usefulness of minimum stent cross sectional area as a predictor of angiographic restenosis after primary percutaneous coronary intervention in acute myocardial infarction (from the HORIZONS-AMI Trial IVUS substudy). Am J Cardiol. 2012;109(4):455-460. + + + Nishi T, Kitahara H, Fujimoto Y, et al. Comparison of 3-dimensional and 2-dimensional quantitative coronary angiography and intravascular ultrasound for functional assessment of coronary lesions. J Cardiol. 2017;69(1):280-286. + + + Natalia M, Forero T, Daemen J. The coronary intravascular lithotripsy system. Interv Cardiol Rev. 2019;14(3):174-181. + + + Nan J, Joseph TA, Bell MR, Singh M, Sandoval Y, Gulati R. Outcomes of excimer laser-contrast angioplasty for stent underexpansion. EuroIntervention. 2021;17(1):78-80. + + + Lee T, Shlofmitz RA, Song L, et al. The effectiveness of excimer laser angioplasty to treat coronary in-stent restenosis with peri-stent calcium as assessed by optical coherence tomography. EuroIntervention. 2019;15(3):e279-e288. + + + Édes IF, Ruzsa Z, Szabó G, et al. Rotational atherectomy of undilatable coronary stents: stent ablation, a clinical perspective and recommendation. EuroIntervention. 2016;12(5):e632-e635. + + + Latib A, Takagi K, Chizzola G, et al. Excimer laser LEsion modification to expand non-dilatable stents: the ELLEMENT registry. Cardiovasc Revasc Med. 2014;15(1):8-12. + + + Hill JM, Kereiakes DJ, Shlofmitz RA, et al. Intravascular lithotripsy for treatment of severely calcified coronary artery disease. J Am Coll Cardiol. 2020;76(22):2635-2646. + + + Ali ZA, Nef H, Escaned J, et al. Safety and effectiveness of coronary intravascular lithotripsy for treatment of severely calcified coronary stenoses: the disrupt CAD II study. Circ Cardiovasc Interv. 2019;12(10):e008434. + + + Brinton TJ, Ali ZA, Hill JM, et al. Feasibility of shockwave coronary intravascular lithotripsy for the treatment of calcified coronary stenoses. Circulation. 2019;139(6):834-836. + + + Ali ZA, McEntegart M, Hill JM, Spratt JC. Intravascular lithotripsy for treatment of stent underexpansion secondary to severe coronary calcification. Eur Heart J. 2020;41(3):485-486. + + + Brunner FJ, Becher PM, Waldeyer C, et al. Intravascular lithotripsy for the treatment of calcium-mediated coronary in-stent restenoses. J Invasive Cardiol. 2021;33(1):25. + + + Alawami M, Thirunavukarasu S, Ahmed J, El-Omar M. Intravascular lithotripsy to treat an underexpanded coronary stent: 4-Month angiographic and OCT follow-up. Catheter Cardiovasc Interv. 2020;96(6):1251-1257. + + + Nikolakopoulos I, Vemmou E, Xenogiannis I, Brilakis ES. Combined use of intravascular lithotripsy and brachytherapy: a new approach for the treatment of recurrent coronary in-stent restenosis. Catheter Cardiovasc Interv. 2021;97(7):1402-1406. + + + Watkins S, Good R, Hill J, Brinton TJ, Oldroyd KG. Intravascular lithotripsy to treat a severely underexpanded coronary stent. EuroIntervention. 2019;15(1):124-125. + + + Alfonso F, Bastante T, Antuña P, et al. Coronary lithoplasty for the treatment of undilatable calcified de novo and in-stent restenosis lesions. JACC Cardiovasc Interv. 2019;12(5):497-499. + + + Tovar Forero MN, Wilschut J, Van Mieghem NM, Daemen J. Coronary lithoplasty: a novel treatment for stent underexpansion. Eur Heart J. 2019;40(2):221. + + + Tovar Forero MN, Sardella G, Salvi N, et al. Coronary lithotripsy for the treatment of underexpanded stents; the international multicentre CRUNCH registry. EuroIntervention. 2022;18:574-581. + + + Ielasi A, Moscarella E, Testa L, et al. Intravascular lithotripsylithotripsy for the management of undilatable coronarycoronary stent: the SMILE registry. Cardiovasc Revasc Med. 2020;21(12):1555-1559. + + + +
+ + + 36490234 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Relationship between sociodemographics, loss of income, and mental health among two-spirit, gay, bisexual, and queer men in Manitoba during the COVID-19 pandemic. + + e0278382 + + 10.1371/journal.pone.0278382 + + This study examined the relationship between loss of income due to the COVID-19 pandemic and worsening mental health among a sample of 366 Two-Spirit, gay, bisexual, queer (2SGBQ+) men in Manitoba. Data were drawn from a cross-sectional online survey among 2SGBQ+ men in Manitoba. Logistic regression assessed the relationship between sociodemographics, loss of income due to COVID-19 (independent variable) and worsening of mental health (analytic outcome). Among all respondents in the sample (N = 366), 55% indicated worsening of their mental health. In logistic regression, compared to participants who did not experience any loss of income, those who experienced loss of income due to the COVID-19 pandemic were significantly more likely to report worsening mental health (Adjusted Odds Ratio [AOR] = 8.32, 95% Confidence Interval[CI] = 3.54-19.54). Compared to participants who self-identified as gay, bisexual-identifying participants were less likely to report worsening mental health (AOR = .35, 95%CI = 0.13-0.96). Finally, as compared to participants who were married or partnered, participants who were dating (AOR = 3.14, 95%CI = 1.60-6.17), single (AOR = 4.08, 95%CI = 1.75-9.52), and separated/divorced/widowed (AOR = 15.08, 95%CI = 2.22-102.51) were all significantly more likely to report experiencing a worsening of mental health due to the COVID-19 pandemic. This study highlights the need to develop robust public strategies for sub-populations of 2SGBQ+ men (non-gay identified sexual minorities and 2SGBQ+ men who may be more socially isolated). Specific targeted and tailored public health interventions designed with the unique needs of 2SGBQ+ men in Manitoba may be required to increase their access to socio-economic and mental health supports. + Copyright: © 2022 Souleymanov et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Souleymanov + Rusty + R + https://orcid.org/0000-0002-2619-2704 + + Faculty of Social Work, University of Manitoba, Winnipeg, MB, Canada. + + + Manitoba HIV-STBBI Collective Impact Network, Winnipeg, MB, Canada. + + + + Amjad + Sana + S + + Department of Community Health Sciences, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. + + + + Moore + Samantha + S + + Department of Community Health Sciences, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. + + + + Star + Jared + J + + Department of Community Health Sciences, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. + + + + McLeod + Albert + A + + Manitoba HIV-STBBI Collective Impact Network, Winnipeg, MB, Canada. + + + Two-Spirit Consultants, Inc., Winnipeg, MB, Canada. + + + + Payne + Michael + M + + Manitoba HIV-STBBI Collective Impact Network, Winnipeg, MB, Canada. + + + Nine Circles Community Health Centre, Winnipeg, MB, Canada. + + + + Ringaert + Laurie + L + + Manitoba HIV-STBBI Collective Impact Network, Winnipeg, MB, Canada. + + + + Larcombe + Linda + L + + Manitoba HIV-STBBI Collective Impact Network, Winnipeg, MB, Canada. + + + Department of Internal Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. + + + + Restall + Gayle + G + + Manitoba HIV-STBBI Collective Impact Network, Winnipeg, MB, Canada. + + + Department of Occupational Therapy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 05 + 12 + + + 2022 + 11 + 15 + + + 2022 + 12 + 9 + 13 + 32 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490234 + 10.1371/journal.pone.0278382 + PONE-D-22-13964 + + +
+ + + 36490232 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Exploring the barriers and facilitators to accessing and utilising mental health services in regional, rural, and remote Australia: A scoping review protocol. + + e0278606 + + 10.1371/journal.pone.0278606 + + Australians from regional, rural, and remote areas face diverse and complex challenges in accessing and utilising mental health services. Previous research has pointed to a range of individual, community, structural, and systemic barriers at play, however, limited literature has synthesised the knowledge on this topic. Parallel to this, information on the facilitators to accessing and utilising mental health services for this group is not well documented. This protocol describes the methodology to undertake a scoping review, which aims to explore the barriers and facilitators associated with accessing and utilising mental health services in regional, rural, and remote Australia. In addition, the scoping review aims to geographically map the identified barriers and facilitators. + This protocol is guided by Arksey and O'Malley's methodological framework. A search strategy will be developed and implemented to identify relevant peer-reviewed and grey literature. Studies will be included if they report on the barriers and/or facilitators associated with accessing and/or utilising mental health services in regional, rural, and remote Australia. Two reviewers will independently screen the data at the title/abstract and full-text stage. One reviewer will extract the relevant data using a predetermined charting form and a second reviewer will validate the included data. A Geographical Information System program will be used to map the location of the studies; locations will be stratified according to the Modified Monash Model and relationships between barriers and facilitators will be analysed. Key findings will be presented in a narrative account and in text, tables, and maps. + This scoping review will provide a contemporary account on the barriers and facilitators to accessing and utilising mental health services for regional, rural, and remote Australians. It is anticipated that the results of this scoping review will have national policy relevance and may be useful to healthcare providers. + Copyright: © 2022 Kavanagh et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Kavanagh + Bianca E + BE + https://orcid.org/0000-0002-1656-2775 + + Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Deakin University, Geelong, VIC, Australia. + + + Deakin Rural Health, Deakin University, Geelong, VIC, Australia. + + + + Beks + Hannah + H + + Deakin Rural Health, Deakin University, Geelong, VIC, Australia. + + + + Versace + Vincent L + VL + + Deakin Rural Health, Deakin University, Geelong, VIC, Australia. + + + + Quirk + Shae E + SE + + Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Deakin University, Geelong, VIC, Australia. + + + Institute of Clinical Medicine, Psychiatry, University of Eastern Finland, Kuopio, Finland. + + + Institute of Clinical Medicine, Kuopio Musculoskeletal Research Unit (KMRU), University of Eastern Finland, Kuopio, Finland. + + + + Williams + Lana J + LJ + + Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Deakin University, Geelong, VIC, Australia. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors declare that they have no competing interests. +
+ + + + 2022 + 02 + 21 + + + 2022 + 11 + 18 + + + 2022 + 12 + 9 + 13 + 32 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490232 + 10.1371/journal.pone.0278606 + PONE-D-22-05190 + + +
+ + + 36490224 + + 2022 + 12 + 09 + +
+ + 1399-0012 + + 36 + 10 + + 2022 + Oct + + + Clinical transplantation + Clin Transplant + + Erratum. + + e14859 + + 10.1111/ctr.14859 + eng + + Published Erratum + +
+ + Denmark + Clin Transplant + 8710240 + 0902-0063 + + IM + + + Clin Transplant. 2022 Sep;36(9):e14706 + 35546523 + + +
+ + + + 2022 + 12 + 9 + 13 + 13 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + ppublish + + 36490224 + 10.1111/ctr.14859 + + +
+ + + 36490228 + + 2022 + 12 + 09 + +
+ + 1980-220X + + 56 + + 2022 + + + Revista da Escola de Enfermagem da U S P + Rev Esc Enferm USP + + Assessment tools for elder abuse: scoping review. + + e20220115 + + S0080-62342022000100808 + 10.1590/1980-220X-REEUSP-2022-0115en + + to map assessment tools for elder abuse and determine the psychometric properties of each one. + scoping review developed according to recommendations of the JBI Institute Reviewer's Manual in databases and gray literature. + seventeen tools were identified for measuring situations of elder abuse. They were categorized into 1) Tools for assessment of risk for abuse, and 2) Tools for identification of abuse. According to risk for abuse, Vulnerability to Abuse Screening Scale was the most prevalent in the literature, with factorial analysis acceptable through four domains, and good internal reliability (0,74). Therefore, Assessment Tool for Domestic Elder Abuse comprises the assessment of six types of elder abuse; however, the study shows psychometric limitation since the internal structure was not evaluated by validity evidences. + seventeen tools to determine the occurrence or risk for elder abuse were identified with different psychometric properties. We recommend the use of more than one of the tools identified for an appropriate measurement of elder abuse situations given the complexity of the phenomenon and the lack of a single instrument that contemplates all its consequences and forms of expression. + + + + Santos-Rodrigues + Renata Clemente Dos + RCD + http://orcid.org/0000-0003-2916-6832 + + Universidade Federal da Paraíba, Centro de Ciências da Saúde, Programa de Pós-Graduação em Enfermagem, João Pessoa, PB, Brazil. + + + + Brandão + Bárbara Maria Lopes da Silva + BMLDS + http://orcid.org/0000-0002-6652-9615 + + Universidade Federal da Paraíba, Centro de Ciências da Saúde, Programa de Pós-Graduação em Enfermagem, João Pessoa, PB, Brazil. + + + + Araújo-Monteiro + Gleicy Karine Nascimento de + GKN + http://orcid.org/0000-0002-4395-6518 + + Universidade Federal da Paraíba, Centro de Ciências da Saúde, Programa de Pós-Graduação em Enfermagem, João Pessoa, PB, Brazil. + + + + Marcolino + Emanuella de Castro + EC + http://orcid.org/0000-0002-6135-8853 + + Centro Universitário Unifacisa, Departamento de Enfermagem, Campina Grande, PB, Brazil. + + + + Moraes + Ronei Marcos de + RM + http://orcid.org/0000-0001-8436-8950 + + Universidade Federal da Paraíba, Centro de Ciências Exatas e da Natureza, Departamento de Estatística. João Pessoa, PB, Brazil. + + + + Souto + Rafaella Queiroga + RQ + http://orcid.org/0000-0002-7368-8497 + + Universidade Federal da Paraíba, Centro de Ciências da Saúde, Programa de Pós-Graduação em Enfermagem, João Pessoa, PB, Brazil. + + + + eng + + Journal Article + + + 2022 + 12 + 05 + +
+ + Brazil + Rev Esc Enferm USP + 0242726 + 0080-6234 + +
+ + + + 2022 + 04 + 05 + + + 2022 + 10 + 17 + + + 2022 + 12 + 9 + 13 + 22 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490228 + S0080-62342022000100808 + 10.1590/1980-220X-REEUSP-2022-0115en + + +
+ + + 36490223 + + 2022 + 12 + 09 + +
+ + 1399-0012 + + 36 + 10 + + 2022 + Oct + + + Clinical transplantation + Clin Transplant + + Are short-term complications associated with poor allograft and patient survival after liver transplantation? A systematic review of the literature and expert panel recommendations. + + e14704 + + 10.1111/ctr.14704 + + Maximizing patient and allograft survival after liver transplant (LT) is important from both a patient care and organ utilization perspective. Although individual studies have addressed the effects of short-term post-LT complications on a limited scale, there has not been a systematic review of the literature formally assessing the potential effects of early complications on long-term outcomes. + To identify whether short-term complications after LT affect allograft and overall survival, to identify short-term complications of particular clinical interest and significance, and to provide recommendations to improve post-LT graft and patient survival. + Ovid MEDLINE, Embase, Scopus, Google Scholar, and Cochrane Central. + A systematic review following PRISMA guidelines and recommendations using the GRADE approach derived from an international expert panel. + The literature review and analysis provided show that short-term complications have a large impact on allograft and patient survival after LT. The complications with the strongest effect on survival are acute kidney injury (AKI), biliary complications, and early allograft dysfunction (EAD). + This panel recommends taking measures to reduce the risk and incidence of short-term complications post-LT. Clinicians should pay particular attention to preventing or ameliorating AKI, biliary complications, and EAD (Quality of evidence; Moderate | Grade of Recommendation; Strong). + © 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. + + + + Alconchel + Felipe + F + https://orcid.org/0000-0002-5483-0312 + + Department of Surgery and Organ Transplantation, Virgen de la Arrixaca University Hospital, Murcia, Spain. + + + Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain. + + + + Tinguely + Pascale + P + https://orcid.org/0000-0001-6836-8045 + + Clinical Service of HPB Surgery and Liver Transplantation, Royal Free London Hospital, NHS Foundation Trust, London, UK. + + + + Frola + Carlo + C + + Clinical Service of HPB Surgery and Liver Transplantation, Royal Free London Hospital, NHS Foundation Trust, London, UK. + + + + Spiro + Michael + M + + Department of Anesthesia and Intensive Care Medicine, Royal Free Hospital, London, UK. + + + Division of Surgery & Interventional Science, University College London, London, UK. + + + + Ciria + Ruben + R + + HPB Surgery and Liver Transplantation, Reina Sofía University Hospital, Córdoba, Spain. + + + + Rodríguez + Gonzalo + G + https://orcid.org/0000-0002-8265-8468 + + Department of General & Digestive Surgery, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Hospital General Universitario de Alicante, Alicante, Spain. + + + + Petrowsky + Henrik + H + + Department of Surgery and Transplantation, University Hospital Zurich, Zurich, Switzerland. + + + + Raptis + Dimitri Aristotle + DA + + Clinical Service of HPB Surgery and Liver Transplantation, Royal Free London Hospital, NHS Foundation Trust, London, UK. + + + Division of Surgery & Interventional Science, University College London, London, UK. + + + + Brombosz + Elizabeth W + EW + https://orcid.org/0000-0002-1734-5959 + + Department of Surgery, Houston Methodist Hospital, Houston, TX, USA. + + + + Ghobrial + Mark + M + https://orcid.org/0000-0001-6077-9595 + + J.C. Walter Jr. Transplant Center, Department of Surgery, Weill Cornell Medical College, Houston Methodist Institute for Academic Medicine, Houston, USA. + + + + ERAS4OLT.org Working Group: Claus Niemann, San Francisco, CA, USA, Joerg-Matthias Pollok, London, UK, Marina Berenguer, Valencia, Spain, Shahi Abdul Ghani, London, UK and Ka Siu Fan, London, UK + + + eng + + Journal Article + +
+ + Denmark + Clin Transplant + 8710240 + 0902-0063 + + IM + + allograft survival + complications + liver transplantation + morbidity + patient survival + recipient survival + short-term outcomes + +
+ + + + 2021 + 12 + 28 + + + 2022 + 02 + 28 + + + 2022 + 12 + 9 + 13 + 13 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + ppublish + + 36490223 + 10.1111/ctr.14704 + + + REFERENCES + + Peng J-K, Hepgul N, Higginson IJ, Gao W. Symptom prevalence and quality of life of patients with end-stage liver disease: a systematic review and meta-analysis. Palliat Med. 2019;33(1):24-36. https://doi.org/10.1177/0269216318807051 + + + Asrani SK, Devarbhavi H, Eaton J, Kamath PS. Burden of liver diseases in the world. J Hepatol. 2019;70(1):151-171. https://doi.org/10.1016/j.jhep.2018.09.014 + + + Heron M. Deaths: leading causes for 2019. Natl Vital Stat Rep. 2021;70(9):1-114. + + + Kruckenberg KM, Shenai N, Dew MA, Switzer G, Hughes C, DiMartini AF. Transplant-related trauma, personal growth and alcohol use outcomes in a cohort of patients receiving transplants for alcohol associated liver disease. 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+ + + 36490235 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + The association between vitamin D receptor polymorphism and phases of chronic hepatitis B infection in HBV carriers in Thailand. + + e0277907 + + 10.1371/journal.pone.0277907 + + Vitamin D receptor (VDR) polymorphism partly regulates the immune system and is associated with hepatic flare in chronic Hepatitis B virus infection (HBV). Our study identified the association between two distinct phases, VDR polymorphisms and HBV inactive carrier (IC) and chronic hepatitis (CH). Chronic HBV patients were enrolled from February to August 2020. An HBV viral load (VL) < 2,000 IU/ml twice for 6 months apart, with no prior history of HBV treatment, defined the IC phase. Six common polymorphisms in the VDR gene, including CdX-2, GATA, FokI, Bsml, ApaI, and TaqI, were studied using real-time PCR. The different outcomes in allele, genotype, and haplotype frequencies in between groups and linkage disequilibrium (LD) mapping were analyzed. Among 324 enrolled patients, there were 163 patients in IC and 161 patients in CH phases. The mean vitamin D levels were not statistically different between groups. The proportion of allele frequencies of CdX-2 in IC and CH was 53.7% and 62.7% for G allele, and 46.3% and 37.3% for A allele (p 0.019). The proportion of GG genotype of CdX-2 was less frequently found in patients with IC compared to that in patients with CH (27% vs 41%, p 0.028). By multivariate analysis, CdX-2 G/A genotypes were independently associated with IC, with adjusted odd ratio (OR) 1.83 (1.10-3.04), p 0.019. The LD mapping of single nucleotide polymorphisms (SNP) revealed high LD scores in Bsml/ApaI/TaqI (BAT) haplotype in both groups while, CdX-2/GATA and GATA/FokI demonstrated high LD score only in CH group. CdX-2 G/A genotypes were independently associated with IC status in Thai patients with chronic HBV infection. The difference in LD of the CdX-2/GATA and GATA/FokI haplotypes in between groups may represent a non-random selection resulting in the variation of immune control. + Copyright: © 2022 Ananchuensook et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Ananchuensook + Prooksa + P + + Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. + + + + Suksawatamnauy + Sirinporn + S + + Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. + + + Center of Excellence in Liver Diseases, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand. + + + Research Unit of Hepatic Fibrosis and Cirrhosis, Department of Medicine, Chulalongkorn University, Bangkok, Thailand. + + + + Thaimai + Panarat + P + + Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. + + + Center of Excellence in Liver Diseases, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand. + + + Research Unit of Hepatic Fibrosis and Cirrhosis, Department of Medicine, Chulalongkorn University, Bangkok, Thailand. + + + + Sriphoosanaphan + Supachaya + S + + Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. + + + Center of Excellence in Liver Diseases, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand. + + + Research Unit of Hepatic Fibrosis and Cirrhosis, Department of Medicine, Chulalongkorn University, Bangkok, Thailand. + + + + Thanapirom + Kessarin + K + + Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. + + + Center of Excellence in Liver Diseases, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand. + + + Research Unit of Hepatic Fibrosis and Cirrhosis, Department of Medicine, Chulalongkorn University, Bangkok, Thailand. + + + + Teerapakpinyo + Chinachote + C + + Chula GenePRO Center, Research Affairs, Faculty of Medicine, Chulalongkorn University and The King Chulalongkorn Memorial Hospital, Bangkok, Thailand. + + + + Pooworawan + Yong + Y + + Center of Excellence in Clinical Virology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. + + + + Komolmit + Piyawat + P + https://orcid.org/0000-0002-1357-9547 + + Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. + + + Center of Excellence in Liver Diseases, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand. + + + Research Unit of Hepatic Fibrosis and Cirrhosis, Department of Medicine, Chulalongkorn University, Bangkok, Thailand. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 03 + 29 + + + 2022 + 11 + 04 + + + 2022 + 12 + 9 + 13 + 32 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490235 + 10.1371/journal.pone.0277907 + PONE-D-22-09302 + + +
+ + + 36490238 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Conjectures and refutations: Species diversity and phylogeny of Australoheros from coastal rivers of southern South America (Teleostei: Cichlidae). + + e0261027 + + 10.1371/journal.pone.0261027 + + Morphological and genetic analyses of species of Australoheros focusing on those distributed in coastal rivers from the Rio de La Plata north to the Rio Buranhém, support recognition of 17 valid species in the genus. Eight species are represented in coastal rivers: A acaroides, A. facetus, A. ipatinguensis, A. oblongus, A. ribeirae, and A. sanguineus are validated from earlier descriptions. Australoheros mboapari is a new species from the Rio Taquari in the Rio Jacuí drainage. Australoheros ricani is a new species from the upper Rio Jacuí. Specimens from the Rio Yaguarón and Rio Tacuary, affluents of Laguna Merín, and tributaries of the Rio Negro, tributary of the Rio Uruguay are assigned to A. minuano pending critical data on specimens from the type locality of A. minuano. Australoheros taura is a junior synonym of A. acaroides. Australoheros autrani, A. saquarema, A. capixaba, A. macaensis, A. perdi, and A. muriae are junior synonyms of A. ipatinguensis. Heros autochthon, A. mattosi, A. macacuensis, A. montanus, A. tavaresi, A. paraibae, and A. barbosae, are junior synonyms of A. oblongus. Heros jenynsii is a junior synonym of A. facetus. + Copyright: © 2022 Santos de Lucena et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Santos de Lucena + Carlos A + CA + + Laboratório de Ictiologia, Museu de Ciências e Tecnologia da Pontifícia Universidade Católica dRio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil. + + + + Kullander + Sven + S + https://orcid.org/0000-0001-6075-0266 + + Department of Zoology, Swedish Museum of Natural History, Stockholm, Sweden. + + + + Norén + Michael + M + https://orcid.org/0000-0003-2561-6760 + + Department of Zoology, Swedish Museum of Natural History, Stockholm, Sweden. + + + + Calegari + Bárbara + B + + Laboratório de Ictiologia, Museu de Ciências e Tecnologia da Pontifícia Universidade Católica dRio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil. + + + Department of Vertebrate Zoology, National Museum of Natural History, Smithsonian Institution, Washington, DC, United States of America. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2021 + 05 + 24 + + + 2021 + 11 + 22 + + + 2022 + 12 + 9 + 13 + 33 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490238 + 10.1371/journal.pone.0261027 + PONE-D-21-16876 + + +
+ + + 36490236 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Predictors of unfavourable treatment outcome in patients diagnosed with drug-resistant tuberculosis in the Torres Strait / Papua New Guinea border region. + + e0266436 + + 10.1371/journal.pone.0266436 + + Drug-resistant tuberculosis (DR-TB) is an ongoing challenge in the Torres Strait Islands (TSI) / Papua New Guinea (PNG) border region. Treatment success rates have historically been poor for patients diagnosed with DR-TB, leading to increased transmission. This study aimed to identify variables associated with unfavourable outcome in patients diagnosed with DR-TB to inform programmatic improvements. A retrospective study of all DR-TB cases who presented to Australian health facilities in the Torres Strait between 1 March 2000 and 31 March 2020 was performed. This time period covers four distinct TB programmatic approaches which reflect Australian and Queensland Government decisions on TB management in this remote region. Univariate and multivariate predictors of unfavourable outcome were analysed. Unfavourable outcome was defined as lost to follow up, treatment failure and death. Successful outcome was defined as cure and treatment completion. In total, 133 patients with resistance to at least one TB drug were identified. The vast majority (123/133; 92%) of DR-TB patients had pulmonary involvement; and of these, 41% (50/123) had both pulmonary and extrapulmonary TB. Unfavourable outcomes were observed in 29% (39/133) of patients. Patients living with human immunodeficiency virus, renal disease or diabetes (4/133; 4/133; 3/133) had an increased frequency of unfavourable outcome (p <0.05), but the numbers were small. Among all 133 DR-TB patients, 41% had a low lymphocyte count, which was significantly associated with unfavourable outcome (p <0.05). We noted a 50% increase in successful outcomes achieved in the 2016-2020 programmatic period, compared to earlier periods (OR 5.3, 95% Confidence Interval [1.3, 20.4]). Being a close contact of a known TB case was associated with improved outcome. While DR-TB treatment outcomes have improved over time, enhanced surveillance for DR-TB, better cross border collaboration and consistent diagnosis and management of comorbidities and other risk factors should further improve patient care and outcomes. + Copyright: © 2022 Foster et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Foster + J'Belle + J + https://orcid.org/0000-0002-4943-4315 + + James Cook University College of Medicine and Dentistry, Townsville, Queensland, Australia. + + + Torres and Cape Tuberculosis Control Unit, Thursday Island, Queensland, Australia. + + + Australian Institute of Tropical Health and Medicine, Townsville, Queensland, Australia. + + + + Mendez + Diana + D + + Australian Institute of Tropical Health and Medicine, Townsville, Queensland, Australia. + + + + Marais + Ben J + BJ + + Sydney Institute for Infectious Diseases and Biosecurity, Westmead, New South Wales, Australia. + + + + Peniyamina + Dunstan + D + + Cairns Tropical Public Health Service, Cairns, Queensland, Australia. + + + + McBryde + Emma S + ES + + James Cook University College of Medicine and Dentistry, Townsville, Queensland, Australia. + + + Torres and Cape Tuberculosis Control Unit, Thursday Island, Queensland, Australia. + + + Australian Institute of Tropical Health and Medicine, Townsville, Queensland, Australia. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 03 + 20 + + + 2022 + 11 + 24 + + + 2022 + 12 + 9 + 13 + 33 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490236 + 10.1371/journal.pone.0266436 + PONE-D-22-08304 + + +
+ + + 36490239 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Analysis and novel methods for capture of normative eye-tracking data in 2.5-month old infants. + + e0278423 + + 10.1371/journal.pone.0278423 + + Development of attention systems is essential for both cognitive and social behavior maturation. Visual behavior has been used to assess development of these attention systems. Yet, given its importance, there is a notable lack of literature detailing successful methods and procedures for using eye-tracking in early infancy to assess oculomotor and attention dynamics. Here we show that eye-tracking technology can be used to automatically record and assess visual behavior in infants as young as 2.5 months, and present normative data describing fixation and saccade behavior at this age. Features of oculomotor dynamics were analyzed from 2.5-month old infants who viewed videos depicting live action, cartoons, geometric shapes, social and non-social scenes. Of the 54 infants enrolled, 50 infants successfully completed the eye-tracking task and high-quality data was collected for 32 of those infants. We demonstrate that modifications specifically tailored for the infant population allowed for consistent tracking of pupil and corneal reflection and minimal data loss. Additionally, we found consistent fixation and saccade behaviors across the entire six-minute duration of the videos, indicating that this is a feasible task for 2.5-month old infants. Moreover, normative oculomotor metrics for a free-viewing task in 2.5-month old infants are documented for the first time as a result of this high-quality data collection. + Copyright: © 2022 Gharib, Thompson. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Gharib + Alma + A + + Department of Computer Science, University of Southern California, Los Angeles, California, United States of America. + + + Program in Developmental Neuroscience and Neurogenetics, The Saban Research Institute and Department of Pediatrics at Children's Hospital of Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America. + + + + Thompson + Barbara L + BL + https://orcid.org/0000-0002-7294-3900 + + Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, Grand Rapids, Michigan, United States of America. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + I have read the journal’s policy and the authors of this manuscript have the following competing interests: BT has received grants from Spectrum Health-MSU Alliance Corporation, a percent of salary from the JBP Foundation, and has served as a Scientific Reviewer for the Department of Defense, U.S. Army Medical Research and Materiel Command, Congressionally Directed Medical Research Programs. AG has received a percent of salary from the JPB Foundation and California Initiative to Advance Precision Medicine. This does not alter our adherence to PLOS ONE policies on sharing data and materials. +
+ + + + 2022 + 07 + 29 + + + 2022 + 11 + 15 + + + 2022 + 12 + 9 + 13 + 33 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490239 + 10.1371/journal.pone.0278423 + PONE-D-22-21369 + + +
+ + + 36490243 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + How does digital village construction influences carbon emission? The case of China. + + e0278533 + + 10.1371/journal.pone.0278533 + + Taking 30 provinces in China from 2011 to 2020 as a research sample, this paper empirically tests the impact of digital village construction on carbon emissions. This study found that there is an "inverted U" curve relationship between digital rural construction and rural carbon emissions. Agricultural planting structure and agricultural technology efficiency are important ways for digital village construction to reduce agricultural carbon emissions. The study also found that the higher the level of economic development, the stronger the carbon emission reduction effect of digital village construction. In addition, there are also significant differences in the carbon emission reduction effect of digital village construction in regions with different environmental regulation intensities. Finally, in terms of the relationship between digital economic activities and carbon emission reduction, the research conclusions of this paper have important implications. + Copyright: © 2022 Hao et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Hao + Aimin + A + + School of Economics, Zhengzhou University of Aeronautics, Zhengzhou, Henan, China. + + + + Hou + Yirui + Y + https://orcid.org/0000-0003-3136-3392 + + School of Economics, Zhengzhou University of Aeronautics, Zhengzhou, Henan, China. + + + + Tan + Jiayin + J + + School of Economics, Zhengzhou University of Aeronautics, Zhengzhou, Henan, China. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 09 + 28 + + + 2022 + 11 + 17 + + + 2022 + 12 + 9 + 13 + 33 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490243 + 10.1371/journal.pone.0278533 + PONE-D-22-26840 + + +
+ + + 36490237 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Hygienic practice during complementary food preparation and associated factors among mothers of children aged 6-24 months in Debark town, northwest Ethiopia, 2021: An overlooked opportunity in the nutrition and health sectors. + + e0275730 + + 10.1371/journal.pone.0275730 + + Hygienic practices during complementary food preparation are suboptimal in developing countries, in Ethiopia in particular. Hygienic complementary food preparation is crucial to prevent childhood communicable diseases like diarrhea and associated malnutrition among children aged 6-24 months. However, in Ethiopia, there is a paucity of evidence on the practice of hygiene during complementary food preparation. Thus, this study is aimed to assess the hygienic practice of complementary food preparation and associated factors among women having children aged 6-24 months in Debark town, northwest Ethiopia. + A community-based cross-sectional study was conducted among 423 mothers with 6-24 months of age children from December 1 to January 30, 2021. A simple random sampling technique was used to select the study participants. Data were collected using an interviewer-administered structured questionnaire. Epi-data version 4.6 and SPSS version 23 software were used for data entry and analysis, respectively. Binary logistic regressions (Bivariable and multivariable) were performed to identify statistically significant variables. Adjusted odds ratio with 95% CI was used to declare statistically significant variables on the basis of p-value < 0.05 in the multivariable logistic regression model. + The study revealed that 44.9% (95% CI (40.2, 49.4%)) of the mothers having children aged 6-24 months had good practice of complementary food preparation. Maternal age of 25-29 years[AOR:3.23, 95% CI: (1.555-9.031)], husband's attained secondary school and above (AOR:2.65, 95% CI (1.211-5.783)], using modern stove for cooking [AOR:3.33,95% CI (1.404-7.874)], having a separate kitchen[AOR: 8.59, 95%Cl: (2.084-35.376], and having a three bowl dishwashing system(AOR: 8.45, 95% CL: (4.444-16.053)) were significantly associated with good hygiene practice of complementary food preparation. + The findings have indicated that the majority of the mothers had poor hygienic practices of complementary food preparation. Mother's age, husband's educational status, type of stove used for cooking, having a separate kitchen, having a three bowl dishwashing system were factors that significantly influenced the hygiene practice of mothers during complementary food preparation. Therefore, training and counseling mothers and caregivers on complementary food processing and preparation is important and such endeavors which inform the development and implementation of complementary food hygiene interventions in urban communities are recommended. + Copyright: © 2022 Zeleke et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Zeleke + Agerie Mengistie + AM + https://orcid.org/0000-0002-9390-9189 + + Department of Midwifery, School of Public Health, Teda Health Science College, Gondar, Ethiopia. + + + + Bayeh + Gashaw Melkie + GM + + Department of Environmental Health, School of Public Health, Teda Health Science College, Gondar, Ethiopia. + + + + Azene + Zelalem Nigussie + ZN + + Department of Women's and Family Health, School of Midwifery, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests. +
+ + + + 2021 + 08 + 12 + + + 2022 + 09 + 06 + + + 2022 + 12 + 9 + 13 + 33 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490237 + 10.1371/journal.pone.0275730 + PONE-D-21-23675 + + +
+ + + 36490242 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Abundance of Phasi-Charoen-like virus in Aedes aegypti mosquito populations in different states of India. + + e0277276 + + 10.1371/journal.pone.0277276 + + Mosquitoes are known to harbor a large number of insect specific viruses (ISV) in addition to viruses of public health importance. These ISVs are highly species specific and are non-pathogenic to humans or domestic animals. However, there is a potential threat of these ISVs evolving into human pathogens by genome alterations. Some ISVs are known to modulate replication of pathogenic viruses by altering the susceptibility of vector mosquitoes to pathogenic viruses, thereby either inhibiting or enhancing transmission of the latter. In the present study, we report predominance of Phasi Charoen-like virus (PCLV, Family: Phenuviridae) contributing to >60% of the total reads in Aedes aegypti mosquitoes collected from Pune district of Maharashtra state using next generation sequencing based metagenomic analysis of viromes. Similar results were also obtained with mosquitoes from Assam, Tamil Nadu and Karnataka states of India. Comparison of Pune mosquito sequences with PCLV Rio (Brazil) isolate showed 98.90%, 99.027% and 98.88% homologies in the S, M and L segments respectively indicating less genetic heterogeneity of PCLV. The study also demonstrated occurrence of transovarial transmission as seen by detection of PCLV in eggs, larvae, pupae and male mosquitoes. Ae. aegypti mosquitoes collected from Pune also showed a large number of reads for viruses belonging to Baculoviridae, Rhabdoviridae, Genomoviridae and Bunyaviridae families. The role of PCLV in the replication of dengue and chikungunya virus is yet not clear. It warrants further studies to know the significance of PCLV and other ISVs on the replication and transmission of Ae. aegypti borne pathogenic viruses, especially in the absence of prophylactics or therapeutics. + Copyright: © 2022 Lole et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Lole + Kavita + K + + ICMR- National Institute of Virology, Pune, Maharashtra, India. + + + + Ramdasi + Ashwini + A + + ICMR- National Institute of Virology, Pune, Maharashtra, India. + + + + Patil + Sucheta + S + https://orcid.org/0000-0002-6188-3789 + + ICMR- National Institute of Virology, Pune, Maharashtra, India. + + + + Thakar + Shivani + S + + ICMR- National Institute of Virology, Pune, Maharashtra, India. + + + + Nath + Amol + A + + ICMR- National Institute of Virology, Pune, Maharashtra, India. + + + + Ghuge + Onkar + O + + ICMR- National Institute of Virology, Pune, Maharashtra, India. + + + + Gangopadhayya + Abhranil + A + + ICMR- National Institute of Virology, Pune, Maharashtra, India. + + + + Sudeep + Anakkathil B + AB + + ICMR- National Institute of Virology, Pune, Maharashtra, India. + + + + Cherian + Sarah + S + + ICMR- National Institute of Virology, Pune, Maharashtra, India. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interest exist. +
+ + + + 2022 + 06 + 16 + + + 2022 + 10 + 24 + + + 2022 + 12 + 9 + 13 + 33 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490242 + 10.1371/journal.pone.0277276 + PONE-D-22-17294 + + +
+ + + 36490240 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Understanding the domain of driving distraction with knowledge graphs. + + e0278822 + + 10.1371/journal.pone.0278822 + + This paper aims to provide insight into the driving distraction domain systematically on the basis of scientific knowledge graphs. For this purpose, 3,790 documents were taken into consideration after retrieving from Web of Science Core Collection and screening, and two types of knowledge graphs were constructed to demonstrate bibliometric information and domain-specific research content respectively. In terms of bibliometric analysis, the evolution of publication and citation numbers reveals the accelerated development of this domain, and trends of multidisciplinary and global participation could be identified according to knowledge graphs from Vosviewer. In terms of research content analysis, a new framework consisting of five dimensions was clarified, including "objective factors", "human factors", "research methods", "data" and "data science". The main entities of this domain were identified and relations between entities were extracted using Natural Language Processing methods with Python 3.9. In addition to the knowledge graph composed of all the keywords and relationships, entities and relations under each dimension were visualized, and relations between relevant dimensions were demonstrated in the form of heat maps. Furthermore, the trend and significance of driving distraction research were discussed, and special attention was given to future directions of this domain. + Copyright: © 2022 Xu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Xu + Wenxia + W + + School of Automotive Studies, Tongji University, Shanghai, China. + + + + Feng + Lei + L + + School of Automotive Studies, Tongji University, Shanghai, China. + + + + Ma + Jun + J + https://orcid.org/0000-0001-9486-7489 + + School of Automotive Studies, Tongji University, Shanghai, China. + + + College of Design and Innovation, Tongji University, Shanghai, China. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 03 + 14 + + + 2022 + 11 + 25 + + + 2022 + 12 + 9 + 13 + 33 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490240 + 10.1371/journal.pone.0278822 + PONE-D-22-07584 + + +
+ + + 36490248 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Depression, anxiety, and burnout among hospital workers during the COVID-19 pandemic: A cross-sectional study. + + e0276861 + + 10.1371/journal.pone.0276861 + + Healthcare personnel have faced unprecedented mental health challenges during the COVID-19 pandemic. The study objective is to assess differences in depression, anxiety, and burnout among healthcare personnel with various occupational roles and whether financial and job strain were associated with these mental health outcomes. + We employed an anonymous survey between July and August 2020 at an urban county hospital in California, USA. We assessed depression, anxiety, and burnout using validated scales, and asked questions on financial strain and job strain. We performed logistic and linear regression analyses. + Nurses (aOR 1.93, 95% CIs 1.12, 3.46), social workers (aOR 2.61, 95% CIs 1.35, 5.17), service workers (aOR 2.55, 95% CIs 1.20, 5.48), and administrative workers (aOR 2.93, 95% CIs 1.57, 5.61) were more likely than physicians to screen positive for depression. The odds of screening positive for anxiety were significantly lower for ancillary workers (aOR 0.32, 95% CIs 0.13-0.72) compared with physicians. Ancillary (aB = -1.77, 95% CIs -1.88, -0.47) and laboratory and pharmacy workers (aB -0.70, 95% CI -1.34, -0.06) reported lower levels of burnout compared with physicians. Financial strain partially accounted for differences in mental health outcomes across job categories. Lack of time to complete tasks and lack of supervisory support were associated with higher odds of screening positive for depression. Less job autonomy was associated with higher odds of screening positive for anxiety and higher burnout levels. + We found significant disparities in mental health outcomes across occupational roles. Policies to mitigate the adverse impact of COVID-19 on health workers' mental health should include non-clinical staff and address financial support and job characteristics for all occupational roles. + Copyright: © 2022 Pala et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Pala + Andrea Norcini + AN + + Columbia School of Social Work (CSSW), New York, NY, United States of America. + + + + Chuang + Jessica C + JC + + San Francisco (UCSF) Division of Occupational and Environmental Medicine, University of California, San Francisco, CA, United States of America. + + + + Chien + Ai + A + + San Francisco (UCSF) Division of Occupational and Environmental Medicine, University of California, San Francisco, CA, United States of America. + + + + Krauth + David M + DM + + San Francisco (UCSF) Division of HIV, University of California, Infectious Disease and Global Medicine, San Francisco, CA, United States of America. + + + + Leitner + Stefano A + SA + + San Francisco (UCSF) Division of Occupational and Environmental Medicine, University of California, San Francisco, CA, United States of America. + + + + Okoye + Nnenna M + NM + + San Francisco (UCSF) Division of Occupational and Environmental Medicine, University of California, San Francisco, CA, United States of America. + + + + Costello + Sadie C + SC + + Division of Environmental Health Sciences, University of California, Berkeley, School of Public Health, CA, United States of America. + + + + Rodriguez + Robert M + RM + + San Francisco (UCSF) Department of Emergency Medicine, University of California, San Francisco, CA, United States of America. + + + + Sheira + Lila A + LA + + San Francisco (UCSF) Division of HIV, University of California, Infectious Disease and Global Medicine, San Francisco, CA, United States of America. + + + + Solomon + Gina + G + + San Francisco (UCSF) Division of Occupational and Environmental Medicine, University of California, San Francisco, CA, United States of America. + + + + Weiser + Sheri D + SD + https://orcid.org/0000-0002-7807-4072 + + San Francisco (UCSF) Division of HIV, University of California, Infectious Disease and Global Medicine, San Francisco, CA, United States of America. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 01 + 12 + + + 2022 + 10 + 16 + + + 2022 + 12 + 9 + 13 + 33 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490248 + 10.1371/journal.pone.0276861 + PONE-D-22-01110 + + +
+ + + 36490247 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Alterations in biceps femoris long head fascicle length, Eccentric hamstring strength qualities and single-leg hop distance throughout the ninety minutes of TSAFT90 simulated football match. + + e0278222 + + 10.1371/journal.pone.0278222 + + Football matches show higher hamstring strain injuries (HSIs) than football training. The occurrence of HSIs increases in the last fifteen minutes of both halves of football matches and shows an incremental trend towards the end of the ninety minutes. + This study aimed to examine football-specific fatigue-induced alterations in risk factors of the HSIs, including biceps femoris long head fascicle length via ultrasonography (BFlh FL), single-leg hop distance, hamstrings' maximal eccentric strength, and single-leg hamstring bridge test (SLHB) performance. + During ninety minutes of the TSAFT90 football simulation, the BFlh FL and single-leg hop distance were measured three times (before, at half-time and after 90 minutes of simulated match-play), and maximal hamstrings eccentric strength and SLHB test scores were recorded twice (before and after simulated match-play) for both legs in physically active participants (n = 15). + Maximal eccentric hamstrings' strength (dominant leg (D): p < 0.001, Hedges' (adjusted) g effect size = -0.969; non-dominant leg (ND): p < 0.001, g = -0.929) and the SLHB performance (D: p < 0.001, g = -1.249; ND: p < 0.001, g = -1.108) showed large decrements immediately after the TSAFT90 intervention. There were no significant alterations in the BFlh FL, and the single-leg hop distance. + Maximal eccentric strength and the SLHB performance of hamstrings are reduced after 90 minutes of simulated football match-play. Practitioners may consider focusing on improving eccentric strength and the SLHB performance. Future studies should examine alterations in the BFlh fascicles' dynamic lengthening and shortening ability during a football match. + Copyright: © 2022 Yagiz et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Yagiz + Gokhan + G + https://orcid.org/0000-0002-9214-1948 + + Institute for Applied Human Physiology, School of Human and Behavioural Sciences, Bangor University, Bangor, United Kingdom. + + + + Dayala + Vinay Kumar + VK + + Institute for Applied Human Physiology, School of Human and Behavioural Sciences, Bangor University, Bangor, United Kingdom. + + + + Williams + Kevin + K + + Institute for Applied Human Physiology, School of Human and Behavioural Sciences, Bangor University, Bangor, United Kingdom. + + + + Owen + Julian Andrew + JA + https://orcid.org/0000-0002-9609-8422 + + Institute for Applied Human Physiology, School of Human and Behavioural Sciences, Bangor University, Bangor, United Kingdom. + + + + Kubis + Hans-Peter + HP + + Institute for Applied Human Physiology, School of Human and Behavioural Sciences, Bangor University, Bangor, United Kingdom. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + Gokhan Yagiz, Vinay Kumar Dayala, Kevin Williams, Julian Andrew Owen, and Hans-Peter Kubis declare that they have no conflict of interest in this article’s content. +
+ + + + 2022 + 08 + 04 + + + 2022 + 11 + 12 + + + 2022 + 12 + 9 + 13 + 33 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490247 + 10.1371/journal.pone.0278222 + PONE-D-22-21868 + + +
+ + + 36490251 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Urban spatial form analysis based on the architectural layout -- Taking Zhengzhou City as an example. + + e0277169 + + 10.1371/journal.pone.0277169 + + The analysis of urban spatial form is the basic research of urban development. Traditional fractal research often focuses on the urban spatial layout, which cannot visually express the specific form, change characteristics and development trend of urban architectural spaces.The urban architectural form is simplified and the basic architectural form templates are extracted, and then, the correlations between architecture form and fractal dimension are built. The results of the case study show that the architectural layout of Zhengzhou City exhibits obvious fractal characteristics, and the combination of the two-dimensional and three-dimensional fractal dimensions is helpful for comprehensively revealing the architectural layout information. Moreover, the fractal dimension of buildings shows that the gradient from the inner to outer ring decreases, similar to the 'annual growth rings' of trees. Obvious differences exist in the fractal dimensions of urban buildings in different directions, reflecting the urban expansion direction. This study promotes the visualization of fractal theory and the expression of fractal theory in spatial gradient, providing theoretical and data reference for urban spatial form optimization. + Copyright: © 2022 Fan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Fan + Qindong + Q + + School of Architecture, North China University of Water Resources and Electric Power, Zhengzhou, China. + + + + Mei + Xuejian + X + https://orcid.org/0000-0002-0027-4082 + + School of Architecture, North China University of Water Resources and Electric Power, Zhengzhou, China. + + + + Zhang + Chenming + C + + School of Architecture, North China University of Water Resources and Electric Power, Zhengzhou, China. + + + + Wang + Hang + H + + Henan Transportation Research Institute CO., LTD, Zhengzhou, China. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 01 + 07 + + + 2022 + 10 + 24 + + + 2022 + 12 + 9 + 13 + 33 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490251 + 10.1371/journal.pone.0277169 + PONE-D-21-40536 + + +
+ + + 36490245 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Impact of increased kidney function on clinical and biological outcomes in real-world patients treated with Direct Oral Anticoagulants. + + e0278693 + + 10.1371/journal.pone.0278693 + + Renal excretion of direct oral anticoagulants (DOACs) varies depending on the drug. Hypothetically, an increased glomerular filtration rate (GFR) may lead to suboptimal dosing and a higher thromboembolic events incidence. However, real-world patient data do not support the theoretical risk. The aim is to analyse DOAC outcomes in patients with normal and high (≥90 mL/min) GFR, focusing on biological parameters and thrombotic/haemorrhagic events. + Observational prospective single-centre study and registry of patients on DOACs. Follow-up was 1,343 patient-years. A bivariate analysis was performed of baseline variables according to GFR (<90 mL/min vs ≥90 mL/min). Anti-Xa activity before and after drug intake (HemosIL, Liquid Anti-Xa, Werfen) was measured for edoxaban, apixaban, and rivaroxaban; diluted thrombin time for dabigatran (HEMOCLOT); and additionally, plasma concentrations in edoxaban (HemosIl, Liquid Anti-Xa suitably calibrated). + 1,135 patients anticoagulated with DOACs were included and 152 patients with GFR ≥90 mL/min. Of 18 serious thrombotic complications during follow-up, 17 occurred in patients with GFR <90 mL/min, and 1 in a patient with GFR ≥90 mL/min. A higher incidence of complications was observed in patients with normal GFR, but the difference was not statistically significant (p>0.05). No statistically significant differences with clinical relevance were observed between the normal or supranormal groups in anti-Xa activity or in edoxaban plasma concentrations. + There was no increased incidence of thrombotic/haemorrhagic complications in our patients treated with DOACs, including 66% treated with edoxaban, and patients with GFR ≥90 mL/min. Likewise, drug anti-Xa activity and edoxaban plasma concentration did not seem to be influenced by GFR. + Copyright: © 2022 Corrochano et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Corrochano + Mariana + M + https://orcid.org/0000-0003-1070-3845 + + Thrombosis and Haemostasis Unit, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. + + + Intitut d'Investigacions Biomèdiques Sant Pau (IIB-Sant Pau), Barcelona, Spain. + + + + Acosta-Isaac + René + R + https://orcid.org/0000-0002-7000-3886 + + Thrombosis and Haemostasis Unit, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. + + + Intitut d'Investigacions Biomèdiques Sant Pau (IIB-Sant Pau), Barcelona, Spain. + + + + Plaza + Melania + M + https://orcid.org/0000-0002-1471-3672 + + Intitut d'Investigacions Biomèdiques Sant Pau (IIB-Sant Pau), Barcelona, Spain. + + + + Muñoz + Rodrigo + R + https://orcid.org/0000-0003-1245-6155 + + Intitut d'Investigacions Biomèdiques Sant Pau (IIB-Sant Pau), Barcelona, Spain. + + + + Mojal + Sergi + S + + Intitut d'Investigacions Biomèdiques Sant Pau (IIB-Sant Pau), Barcelona, Spain. + + + + Moret + Carla + C + https://orcid.org/0000-0002-0704-7456 + + Thrombosis and Haemostasis Unit, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. + + + Intitut d'Investigacions Biomèdiques Sant Pau (IIB-Sant Pau), Barcelona, Spain. + + + + Souto + Joan Carles + JC + + Thrombosis and Haemostasis Unit, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. + + + Intitut d'Investigacions Biomèdiques Sant Pau (IIB-Sant Pau), Barcelona, Spain. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + I have read the journal’s policy and the authors of this manuscript have the following competing interests: “The HSCSP Haemostasis and Thrombosis and the IIB-Sant Pau receive funding from Daiichi-Sankyo to develop and maintain the MACACOD (Real-life Clinical Outcomes of Direct Oral Anticoagulants) registry, of which this study is part. Only the authors have participated in study design, data collection and analysis, and manuscript preparation. Dr Souto has received honoraria or financial support for travel, accommodation, or expenses from Laboratorios Rovi, Leo Pharma, Baxter, Sanofi, Boehringer Ingelheim, Pfizer, Bristol Myers Squibb, Roche, Daiichi-Sankyo, and Stago Laboratories. He also holds advisory position in Devicare. The remaining authors declare no conflicts of interest. This does not alter our adherence to PLOS ONE policies on sharing data and materials. +
+ + + + 2022 + 06 + 02 + + + 2022 + 11 + 21 + + + 2022 + 12 + 9 + 13 + 33 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490245 + 10.1371/journal.pone.0278693 + PONE-D-22-15972 + + +
+ + + 36490241 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Factors associated with non-response to naldemedine for opioid-induced constipation in cancer patients: A subgroup analysis. + + e0278823 + + 10.1371/journal.pone.0278823 + + Opioid-induced constipation (OIC) is one of the most common adverse events of opioid therapy and can severely reduce quality of life (QOL). Naldemedine is the orally available peripheral-acting μ-opioid receptor antagonist approved for OIC treatment. However in daily clinical practice, some cancer patients show insufficient control of OIC even while receiving naldemedine. + To identify factors associated with non-response to naldemedine in cancer patients. + This study retrospectively analyzed 127 cancer patients prescribed naldemedine at Seirei Hamamatsu General Hospital in Japan between November 2016 and June 2021. For the regression analysis of factors associated with OIC, variables were extracted manually from electronic medical records. Naldemedine had been prescribed by the attending physician after the presence of OIC had been defined with reference to Rome IV diagnostic criteria. Naldemedine was evaluated as "effective" in cases where the number of defecations increased at least once in the first 3 days after starting naldemedine. Multivariate logistic regression analysis was performed to identify factors associated with non-response to naldemedine. The data used were from the group of patients who received naldemedine in our previous study. + Factors significantly associated with non-response to naldemedine included chemotherapy with taxanes within 1 month of evaluation of naldemedine effect (odds ratio [OR] = 0.063; 95% confidence interval [CI] = 0.007-0.568), and addition of or switching to naldemedine due to insufficient efficacy of prior laxatives (OR = 0.352, 95% CI = 0.129-0.966). + The identification of factors associated with non-response to naldemedine prescribed for OIC may help improve QOL among cancer patients. + Copyright: © 2022 Kanbayashi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Kanbayashi + Yuko + Y + https://orcid.org/0000-0002-0095-2293 + + Faculty of Pharmacy, Department of Education and Research Center for Clinical Pharmacy, Osaka Medical and Pharmaceutical University, Takatsuki, Japan. + + + + Shimizu + Mayumi + M + + Department of Pharmacy, Seirei Hamamatsu General Hospital, Hamamatsu, Japan. + + + + Ishizuka + Yuichi + Y + + Department of Pharmacy, Seirei Hamamatsu General Hospital, Hamamatsu, Japan. + + + + Sawa + Shohei + S + + Department of Pharmacy, Seirei Hamamatsu General Hospital, Hamamatsu, Japan. + + + + Yabe + Katsushige + K + + Department of Pharmacy, Seirei Hamamatsu General Hospital, Hamamatsu, Japan. + + + + Uchida + Mayako + M + + Department of Education and Research Center for Pharmacy Practice, Doshisha Women's College of Liberal Arts, Kyotanabe, Japan. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 05 + 21 + + + 2022 + 11 + 25 + + + 2022 + 12 + 9 + 13 + 33 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490241 + 10.1371/journal.pone.0278823 + PONE-D-22-14788 + + +
+ + + 36490249 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + A comparative study of RF heating of deep brain stimulation devices in vertical vs. horizontal MRI systems. + + e0278187 + + 10.1371/journal.pone.0278187 + + The majority of studies that assess magnetic resonance imaging (MRI) induced radiofrequency (RF) heating of the tissue when active electronic implants are present have been performed in horizontal, closed-bore MRI systems. Vertical, open-bore MRI systems have a 90° rotated magnet and a fundamentally different RF coil geometry, thus generating a substantially different RF field distribution inside the body. Little is known about the RF heating of elongated implants such as deep brain stimulation (DBS) devices in this class of scanners. Here, we conducted the first large-scale experimental study investigating whether RF heating was significantly different in a 1.2 T vertical field MRI scanner (Oasis, Fujifilm Healthcare) compared to a 1.5 T horizontal field MRI scanner (Aera, Siemens Healthineers). A commercial DBS device mimicking 30 realistic patient-derived lead trajectories extracted from postoperative computed tomography images of patients who underwent DBS surgery at our institution was implanted in a multi-material, anthropomorphic phantom. RF heating around the DBS lead was measured during four minutes of high-SAR RF exposure. Additionally, we performed electromagnetic simulations with leads of various internal structures to examine this effect on RF heating. When controlling for RMS B1+, the temperature increase around the DBS lead-tip was significantly lower in the vertical scanner compared to the horizontal scanner (0.33 ± 0.24°C vs. 4.19 ± 2.29°C). Electromagnetic simulations demonstrated up to a 17-fold reduction in the maximum of 0.1g-averaged SAR in the tissue surrounding the lead-tip in the vertical scanner compared to the horizontal scanner. Results were consistent across leads with straight and helical internal wires. Radiofrequency heating and power deposition around the DBS lead-tip were substantially lower in the 1.2 T vertical scanner compared to the 1.5 T horizontal scanner. Simulations with different lead structures suggest that the results may extend to leads from other manufacturers. + Copyright: © 2022 Vu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Vu + Jasmine + J + + Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, Illinois, United States of America. + + + Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America. + + + + Bhusal + Bhumi + B + + Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America. + + + + Nguyen + Bach T + BT + + Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America. + + + + Sanpitak + Pia + P + + Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, Illinois, United States of America. + + + Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America. + + + + Nowac + Elizabeth + E + + Illinois Bone and Joint Institute (IBJI), Wilmette, Illinois, United States of America. + + + + Pilitsis + Julie + J + + Department of Neurosciences & Experimental Therapeutics, Albany Medical College, Albany, New York, United States of America. + + + + Rosenow + Joshua + J + https://orcid.org/0000-0001-7726-2496 + + Department of Neurosurgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America. + + + + Golestanirad + Laleh + L + https://orcid.org/0000-0003-3869-6114 + + Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, Illinois, United States of America. + + + Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 08 + 16 + + + 2022 + 11 + 11 + + + 2022 + 12 + 9 + 13 + 33 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490249 + 10.1371/journal.pone.0278187 + PONE-D-22-22994 + + +
+ + + 36490250 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Effectively computing transition patterns with privacy-preserved trajectory datasets. + + e0278744 + + 10.1371/journal.pone.0278744 + + Recent advances in positioning techniques, along with the widespread use of mobile devices, make it easier to monitor and collect user trajectory information during their daily activities. An ever-growing abundance of data about trajectories of individual users paves the way for various applications that utilize user mobility information. One of the most common analysis tasks in these new applications is to extract the sequential transition patterns between two consecutive timestamps from a collection of trajectories. Such patterns have been widely exploited in diverse applications to predict and recommend next user locations based on the current position. Thus, in this paper, we explore the computation of the transition patterns, especially with a trajectory dataset collected using differential privacy, which is a de facto standard for privacy-preserving data collection and processing. Specifically, the proposed scheme relies on geo-indistinguishability, which is a variant of the well-known differential privacy, to collect trajectory data from users in a privacy-preserving manner, and exploits the functionality of the expectation-maximization algorithm to precisely estimate hidden transition patterns based on perturbed trajectory datasets collected under geo-indistinguishability. Experimental results using real trajectory datasets confirm that a good estimation of transition pattern can be achieved with the proposed method. + Copyright: © 2022 Kim, Jang. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Kim + Jong Wook + JW + https://orcid.org/0000-0001-8373-1893 + + Department of Computer Science, Sangmyung University, Seoul, Korea. + + + + Jang + Beakcheol + B + + Graduate School of Information, Yonsei University, Seoul, Korea. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 06 + 30 + + + 2022 + 11 + 22 + + + 2022 + 12 + 9 + 13 + 33 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490250 + 10.1371/journal.pone.0278744 + PONE-D-22-18635 + + +
+ + + 36490246 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Women engagement in agriculture and human capital development in developing countries: An African sub-regional analysis. + + e0277519 + + 10.1371/journal.pone.0277519 + + Considering the relevant role played by women in agriculture in Africa, this study sets out to examine how women's engagement in agriculture contributes to human capital development in selected African countries. The study engagedpanel data of selected 33 African countries spanning the period of 2000 to 2019. The study applied the Pooled Ordinary Least Squares (POLS) and the fixed effects based on the Hausman specification. Findings show that engagement of women in agriculture, though significant, but negatively related to human capital development in Africa. The implication of this is that an increase in women's engagement in agriculture without the required level of education and training and access to agricultural resources may have a negative impact on human capital development. Therefore, the study recommended that it is necessary to train women in terms of agricultural skills needed to improve human capital development in Africa. + Copyright: © 2022 Matthew et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Matthew + Oluwatoyin + O + + Department of Economics and Development Studies, Centre for Economic Policy and Development Research (CEPDeR), Covenant University, Ota, Nigeria. + + + + Osabohien + Romanus + R + https://orcid.org/0000-0003-4359-1368 + + Department of Economics and Development Studies, Centre for Economic Policy and Development Research (CEPDeR), Covenant University, Ota, Nigeria. + + + Honorary Research Fellow, ILMA University, Karachi, Pakistan. + + + + Lakhani + Kanwal Hammad + KH + + Department of Business Administration, ILMA University, Karachi, Pakistan. + + + + Aderounmu + Busayo + B + + Department of Economics and Development Studies, Centre for Economic Policy and Development Research (CEPDeR), Covenant University, Ota, Nigeria. + + + + Osadolor + Nneka E + NE + + Department of Economics, University of Benin, Benin City, Nigeria. + + + + Adediran + Oluwasogo + O + https://orcid.org/0000-0002-8598-8630 + + Department of Economics and Development Studies, Centre for Economic Policy and Development Research (CEPDeR), Covenant University, Ota, Nigeria. + + + + Mabinuori + Oladotun + O + + Department of Economics, Accounting and Finance, Bells University of Technology, Ota, Nigeria. + + + + Igharo + Amechi E + AE + + Department of Economics and Developmental Studies, Havilla University, Nde-Ikom, Nigeria. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2021 + 09 + 18 + + + 2022 + 10 + 29 + + + 2022 + 12 + 9 + 13 + 33 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490246 + 10.1371/journal.pone.0277519 + PONE-D-21-30219 + + +
+ + + 36490244 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + An early interactive human coaching via a mobile application to improve quality of life in patients who underwent gastrectomy for gastric cancer: Design and protocol of a randomized controlled trial. + + e0278370 + + 10.1371/journal.pone.0278370 + + After gastrectomy, patients may experience the postgastrectomy syndrome and face difficulties adapting to everyday diet. Recently, human health coaching via a mobile application (app) has been used for obese patients or patients with chronic diseases, with significant improvements in clinical outcomes. The aim of this study is to evaluate and compare the effects of human health coaching via a mobile app and conventional face-to-face counseling in patients who underwent gastrectomy for gastric cancers. + This study is a single-institution, prospective randomized controlled trial comparing the mobile health and face-to-face counselling groups. After randomization, participants assigned to the mobile health coaching group will receive health coaching via a mobile app for 3 months after discharge, and the assigned coaches will provide personalized advice based on the self-recorded health data. Participants in the face-to-face group will have 1- and 3-months postoperative dietary consultations with a clinical dietitian. The primary endpoint is the food restriction score on the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-STO22, and secondary endpoints included all other quality of life scale scores and nutritional parameters. The calculated sample size is 180, and the outcomes will be measured until 1-year post-surgery. + This study will show the efficacy of human health coaching via a mobile app on dietary adaptation in patients who underwent gastrectomy. A relational approach based on personal data and timely intervention using a mobile platform could reduce patients' trial and error and improve quality of life. + ClinicalTrials.gov, NCT04394585, Registered 19 May, 2020 -Retrospectively registered, http://clinicaltrials.gov/ct2/show/NCT040394585. + Copyright: © 2022 Kim et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Kim + Hak Jin + HJ + + Department of Cardiology, Center for Clinical Specialty, National Cancer Center, Goyang, Republic of Korea. + + + + Yoon + Hong Man + HM + + Center for Gastric Cancer, Research Institute & Hospital, National Cancer Center, Goyang, Republic of Korea. + + + + Ryu + Keun Won + KW + + Center for Gastric Cancer, Research Institute & Hospital, National Cancer Center, Goyang, Republic of Korea. + + + + Kim + Young-Woo + YW + + Center for Gastric Cancer, Research Institute & Hospital, National Cancer Center, Goyang, Republic of Korea. + + + + Kim + So Young + SY + + Department of Clinical Nutrition, National Cancer Center, Goyang, Republic of Korea. + + + + Oh + Jin Myoung + JM + + Department of Clinical Nutrition, National Cancer Center, Goyang, Republic of Korea. + + + + Wie + Gyung Ah + GA + + Department of Clinical Nutrition, National Cancer Center, Goyang, Republic of Korea. + + + + Ko + Hyunyoung + H + https://orcid.org/0000-0002-0791-1208 + + Research and Development Team, Noom Inc, Seoul, Republic of Korea. + + + + Lee + Jungeun + J + + Research and Development Team, Noom Inc, Seoul, Republic of Korea. + + + + Kim + Youngin + Y + + Research and Development Team, Noom Inc, Seoul, Republic of Korea. + + + + Cho + Hyunsoon + H + + Department of Cancer Control and Population Health, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea. + + + + Eom + Bang Wool + BW + https://orcid.org/0000-0002-0332-2051 + + Center for Gastric Cancer, Research Institute & Hospital, National Cancer Center, Goyang, Republic of Korea. + + + + eng + + + ClinicalTrials.gov + + NCT04394585 + + + + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have read the journal’s policy and have the following competing interests: HK, JL, and YK are paid employees of Noom Inc. There are no patents, products in development or marketed products associated with this research to declare. This does not alter our adherence to PLOS ONE policies on sharing data and materials. +
+ + + + 2021 + 05 + 24 + + + 2022 + 10 + 04 + + + 2022 + 12 + 9 + 13 + 33 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490244 + 10.1371/journal.pone.0278370 + PONE-D-21-12917 + + +
+ + + 36490253 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Obeticholic acid treatment ameliorates the cardiac dysfunction in NASH mice. + + e0276717 + + 10.1371/journal.pone.0276717 + + Suppression of cardiac iinflammasome, which can be inhibited by Farnesoid X receptor (FXR) agonist, can ameliorate cardiac inflammation and fibrosis. Increased cardiac inflammasome decrease the abundance of regulatory T (Treg) cells and exacerbate cardiac dysfunction. Interaction between cardiomyocytes and Treg cells is involved in the development of nonalcoholic steatohepatitis (NASH)-related cardiac dysfunction. + This study evaluates whether the FXR agonist obeticholic acid (OCA) treatment improves NASH-associated cardiac dysfunction. + The in vivo and in vitro mechanisms and effects of two weeks of OCA treatment on inflammasome and Treg dysregulation-related cardiac dysfunction in NASH mice (NASH-OCA) at systemic, tissue and cellular levels were investigated. + The OCA treatment suppressed the serum and cardiac inflammasome levels, reduced the cardiac infiltrated CD3+ T cells, increased the cardiac Treg-represented anti-inflammatory cytokines (IL-10/IL-10R) and improved cardiac inflammation, fibrosis and function [decreased left ventricle (LV) mass and increased fractional shortening (FS)] in NASH-OCA mice. The percentages of OCA-decreased cardiac fibrosis and OCA-increased FS were positively correlated with the percentage of OCA-increased levels of cardiac FXR and IL-10/IL-10R. In the Treg cells from NASH-OCA mice spleen, in comparison with the Treg cells of the NASH group, higher intracellular FXR but lower inflammasome levels, and more proliferative/active and less apoptotic cells were observed. Incubation of H9c2 cardiomyoblasts with Treg-NASHcm [supernatant of Treg from NASH mice as condition medium (cm)], increased inflammasome levels, decreased the proliferative/active cells, suppressed the intracellular FXR, and downregulated differentiation/contraction marker. The Treg-NASHcm-induced hypocontractility of H9c2 can be attenuated by co-incubation with OCA, and the OCA-related effects were abolished by siIL-10R pretreatment. + Chronic FXR activation with OCA is a potential strategy for activating IL-10/IL-10R signalling, reversing cardiac regulatory T cell dysfunction, and improving inflammasome-mediated NASH-related cardiac dysfunction. + Copyright: © 2022 Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Liu + Szu-Yu + SY + + Department of Medical Education, Clinical Innovation Center, Medical Innovation and Research Office, Taipei Veterans General Hospital, Taipei, Taiwan. + + + Faculty of Medicine, School of Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan. + + + + Huang + Chia-Chang + CC + https://orcid.org/0000-0002-1313-4628 + + Faculty of Medicine, School of Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan. + + + Faculty of Medicine, Institute of Clinical Medicine, School of Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan. + + + + Yang + Ying-Ying + YY + https://orcid.org/0000-0003-2919-9853 + + Department of Medical Education, Clinical Innovation Center, Medical Innovation and Research Office, Taipei Veterans General Hospital, Taipei, Taiwan. + + + Faculty of Medicine, School of Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan. + + + + Huang + Shiang-Fen + SF + + Faculty of Medicine, School of Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan. + + + Taipei Veterans General Hospital, Taipei, Taiwan. + + + + Lee + Tzung-Yan + TY + + Graduate Institute of Traditional Chinese Medicine, Chang Guang Memorial Hospital, Linkou, Taiwan. + + + + Li + Tzu-Hao + TH + + Faculty of Medicine, School of Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan. + + + Faculty of Medicine, Institute of Clinical Medicine, School of Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan. + + + Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Shin Kong Wu Ho-Su Memorial Foundation, Taipei, Taiwan. + + + + Hou + Ming-Chih + MC + + Faculty of Medicine, School of Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan. + + + Taipei Veterans General Hospital, Taipei, Taiwan. + + + + Lin + Han-Chieh + HC + + Taipei Veterans General Hospital, Taipei, Taiwan. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 07 + 13 + + + 2022 + 10 + 11 + + + 2022 + 12 + 9 + 13 + 33 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490253 + 10.1371/journal.pone.0276717 + PONE-D-22-19785 + + +
+ + + 36490252 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Abnormalities of hippocampus and frontal lobes in heart failure patients and animal models with cognitive impairment or depression: A systematic review. + + e0278398 + + 10.1371/journal.pone.0278398 + + This systematic review aimed to study the hippocampal and frontal changes of heart failure (HF) patients and HF animal models with cognitive impairment or depression. + A systematic review of the literature was conducted independently by reviewers using PubMed, Web of Science, Embase, and the Cochrane Library databases. + 30 studies were included, involving 17 pieces of clinical research on HF patients and 13 studies of HF animal models. In HF patients, the hippocampal injuries were shown in the reduction of volume, CBF, glucose metabolism, and gray matter, which were mainly observed in the right hippocampus. The frontal damages were only in reduced gray matter and have no difference between the right and left sides. The included HF animal model studies were generalized and demonstrated the changes in inflammation and apoptosis, synaptic reduction, and neurotransmitter disorders in the hippocampus and frontal lobes. The results of HF animal model studies complemented the clinical observations by providing potential mechanistic explanations of the changes in the hippocampus and frontal lobes. + Copyright: © 2022 Lu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Lu + Ziwen + Z + + Key Laboratory of Chinese Internal Medicine of Ministry of Education and Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China. + + + + Teng + Yu + Y + + Key Laboratory of Chinese Internal Medicine of Ministry of Education and Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China. + + + + Wang + Lei + L + + Key Laboratory of Chinese Internal Medicine of Ministry of Education and Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China. + + + + Jiang + Yangyang + Y + + Key Laboratory of Chinese Internal Medicine of Ministry of Education and Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China. + + + + Li + Tong + T + + Key Laboratory of Chinese Internal Medicine of Ministry of Education and Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China. + + + + Chen + Shiqi + S + + Key Laboratory of Chinese Internal Medicine of Ministry of Education and Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China. + + + + Wang + Baofu + B + + Key Laboratory of Chinese Internal Medicine of Ministry of Education and Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China. + + + + Li + Yang + Y + + Key Laboratory of Chinese Internal Medicine of Ministry of Education and Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China. + + + + Yang + Jingjing + J + + Key Laboratory of Chinese Internal Medicine of Ministry of Education and Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China. + + + + Wu + Xiaoxiao + X + + Key Laboratory of Chinese Internal Medicine of Ministry of Education and Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China. + + + + Cheng + Weiting + W + + Key Laboratory of Chinese Internal Medicine of Ministry of Education and Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China. + + + + Cui + Xiangning + X + + Department of Cardiovascular, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China. + + + + Zhao + Mingjing + M + https://orcid.org/0000-0003-2738-7500 + + Key Laboratory of Chinese Internal Medicine of Ministry of Education and Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 08 + 20 + + + 2022 + 11 + 15 + + + 2022 + 12 + 9 + 13 + 33 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490252 + 10.1371/journal.pone.0278398 + PONE-D-22-23143 + + +
+ + + 36490254 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Multiscale compression-induced restructuring of stacked lipid bilayers: From buckling delamination to molecular packing. + + e0275079 + + 10.1371/journal.pone.0275079 + + Lipid membranes in nature adapt and reconfigure to changes in composition, temperature, humidity, and mechanics. For instance, the oscillating mechanical forces on lung cells and alveoli influence membrane synthesis and structure during breathing. However, despite advances in the understanding of lipid membrane phase behavior and mechanics of tissue, there is a critical knowledge gap regarding the response of lipid membranes to micromechanical forces. Most studies of lipid membrane mechanics use supported lipid bilayer systems missing the structural complexity of pulmonary lipids in alveolar membranes comprising multi-bilayer interconnected stacks. Here, we elucidate the collective response of the major component of pulmonary lipids to strain in the form of multi-bilayer stacks supported on flexible elastomer substrates. We utilize X-ray diffraction, scanning probe microscopy, confocal microscopy, and molecular dynamics simulation to show that lipid multilayered films both in gel and fluid states evolve structurally and mechanically in response to compression at multiple length scales. Specifically, compression leads to increased disorder of lipid alkyl chains comparable to the effect of cholesterol on gel phases as a direct result of the formation of nanoscale undulations in the lipid multilayers, also inducing buckling delamination and enhancing multi-bilayer alignment. We propose this cooperative short- and long-range reconfiguration of lipid multilayered films under compression constitutes a mechanism to accommodate stress and substrate topography. Our work raises fundamental insights regarding the adaptability of complex lipid membranes to mechanical stimuli. This is critical to several technologies requiring mechanically reconfigurable surfaces such as the development of electronic devices interfacing biological materials. + Copyright: © 2022 Porras-Gómez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Porras-Gómez + Marilyn + M + https://orcid.org/0000-0002-1601-1308 + + Department of Materials Science and Engineering, University of Illinois Urbana-Champaign, Urbana, Illinois, United States of America. + + + + Kim + Hyunchul + H + + Department of Mechanical Science and Engineering, University of Illinois Urbana-Champaign, Urbana, Illinois, United States of America. + + + + Dronadula + Mohan Teja + MT + + Walker Department of Mechanical Engineering, Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, Texas, United States of America. + + + + Kambar + Nurila + N + + Department of Materials Science and Engineering, University of Illinois Urbana-Champaign, Urbana, Illinois, United States of America. + + + + Metellus + Christopher J B + CJB + https://orcid.org/0000-0002-2356-7195 + + Department of Mechanical Science and Engineering, University of Illinois Urbana-Champaign, Urbana, Illinois, United States of America. + + + + Aluru + Narayana R + NR + + Walker Department of Mechanical Engineering, Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, Texas, United States of America. + + + + van der Zande + Arend + A + + Department of Mechanical Science and Engineering, University of Illinois Urbana-Champaign, Urbana, Illinois, United States of America. + + + + Leal + Cecília + C + https://orcid.org/0000-0001-5972-508X + + Department of Materials Science and Engineering, University of Illinois Urbana-Champaign, Urbana, Illinois, United States of America. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 09 + 09 + + + 2022 + 11 + 23 + + + 2022 + 12 + 9 + 13 + 33 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490254 + 10.1371/journal.pone.0275079 + PONE-D-22-25179 + + +
+ + + 36490255 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Association of muscle mass measured by D3-Creatine (D3Cr), sarcopenic obesity, and insulin-glucose homeostasis in postmenopausal women. + + e0278723 + + 10.1371/journal.pone.0278723 + + The D3-Creatine (D3Cr) dilution method is a direct and accurate measure of skeletal muscle mass. In this study, we examined the association of D3Cr muscle mass with measures of insulin-glucose homeostasis in community dwelling postmenopausal women. Additionally, we examined association of sarcopenic obesity, defined as low D3Cr muscle mass and high percent body fat, with fasting plasma glucose, insulin, hemoglobin A1c and insulin resistance. Insulin resistance was measured by the homeostatic measure of insulin resistance (HOMA-IR). This pilot study included 74 participants (mean age = 82.3 years) from the Women's Health Initiative-Buffalo site. The D3Cr method was initiated at a clinic visit and used to measure muscle mass via remote urine sample collection. Descriptive and graphical approaches and age-adjusted linear regression models were used to analyze study data. We examined muscle mass as an absolute value (kg) and scaled to body weight (D3Cr muscle mass/kg). There was an inverse relationship between skeletal muscle mass, and impaired insulin-glucose homeostasis. Women with low muscle mass had higher levels of insulin (uIU/mL; β = -0.40; 95% CI: -0.79, -0.01), fasting plasma glucose (mg/dL; β = -0.1; 95% CI: -0.2, 0.03), HbA1c (%; β = -2.30; 95% CI: -5.7, 1.1), and calculated homeostatic model of insulin resistance, HOMA-IR, (β = -1.49; 95% CI: -2.9, -0.1). Sarcopenic obesity was common in this population of women; 41% of participants were categorized as having low muscle mass and high percent body fat. Results demonstrate that D3Cr muscle mass is independently associated with measures of insulin-glucose homeostasis, but obesity is a stronger predictor of insulin resistance than muscle mass. + Copyright: © 2022 Banack et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Banack + Hailey R + HR + https://orcid.org/0000-0002-6230-2245 + + Epidemiology Division, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada. + + + School of Public Health and Health Professions, University at Buffalo, Buffalo, New York, United States of America. + + + + LaMonte + Michael J + MJ + + School of Public Health and Health Professions, University at Buffalo, Buffalo, New York, United States of America. + + + + Manson + JoAnn E + JE + + Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America. + + + Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America. + + + + Zhu + Kexin + K + + School of Public Health and Health Professions, University at Buffalo, Buffalo, New York, United States of America. + + + + Evans + William J + WJ + + Duke University Medical Center, Division of Geriatrics, Durham, North Carolina, United States of America. + + + Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California, United States of America. + + + + Shankaran + Mahalakshmi + M + + Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California, United States of America. + + + + Wactawski-Wende + Jean + J + + School of Public Health and Health Professions, University at Buffalo, Buffalo, New York, United States of America. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 08 + 10 + + + 2022 + 11 + 21 + + + 2022 + 12 + 9 + 13 + 33 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490255 + 10.1371/journal.pone.0278723 + PONE-D-22-22442 + + +
+ + + 36490258 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Assessing the dimensionality of scores derived from the Revised Formal Thought Disorder Self-Report Scale in schizotypy. + + e0278841 + + 10.1371/journal.pone.0278841 + + The current work explored the dimensionality and convergent validity of responses to Barrera et al.'s (2015) 29-item Formal Thought Disorder-Self Scale (FTD-SS) obtained in two non-clinical samples. Exploratory factor analyses were conducted in Sample 1 (n = 324), yielding evidence of three correlated factors, although simple structure was not achieved until nine items were removed. Support for the correlated three factors model of responses to the revised 20-item scale (FTD-SS-R) was replicated when a confirmatory factor analysis was conducted in Sample 2 (n = 610). Finally, convergent associations were found between FTD-SS-R scores and scores from other schizotypy measures across both samples, though these measures only explained half of the variance in FTD-SS-R scores. Additional research is needed to evaluate the appropriateness of the items and incremental validity of the scale in non-clinical samples. + Copyright: © 2022 Sumner et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Sumner + Philip J + PJ + https://orcid.org/0000-0002-5025-3909 + + Centre for Mental Health, Swinburne University of Technology, Melbourne, VIC, Australia. + + + + Meyer + Denny + D + + Centre for Mental Health, Swinburne University of Technology, Melbourne, VIC, Australia. + + + + Carruthers + Sean P + SP + + Centre for Mental Health, Swinburne University of Technology, Melbourne, VIC, Australia. + + + + Amirul Islam + Fakir M + FM + + Department of Health Science and Biostatistics, Swinburne University of Technology, Melbourne, VIC, Australia. + + + + Rossell + Susan L + SL + + Centre for Mental Health, Swinburne University of Technology, Melbourne, VIC, Australia. + + + Department of Mental Health, St Vincent's Hospital, Melbourne, VIC, Australia. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2021 + 07 + 28 + + + 2022 + 11 + 24 + + + 2022 + 12 + 9 + 13 + 34 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490258 + 10.1371/journal.pone.0278841 + PONE-D-21-24412 + + +
+ + + 36490267 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Agronomic treatments to avoid presence of seeds in Nadorcott mandarin II. Effect on seed number per fruit and yield. + + e0278934 + + 10.1371/journal.pone.0278934 + + Nadorcott is a well-established and appreciated mandarin by the fresh market. However, it produces seeds due to cross-pollination with other compatible varieties, which is quite frequent in most producing countries. Consumers prefer seedless mandarins and, therefore, citrus growers need techniques to avoid seeds forming. This study aims to evaluate the effect of six treatments (ammonium nitrate, potassium nitrate, sulfur, saccharose, methylcellulose, callose) on seed number per fruit when applied to Nadorcott trees. In this way, we evaluate which of them is more efficient and can be used in the future as an agronomic treatment to avoid seeds in mandarins. The effect of treatments on yield and fruit quality is also reported. To fulfill this main objective, a randomized complete block design experiment with three applications at flowering was performed on trees. Of the six tested treatments, only elemental sulfur was able to significantly reduce seed number by 87% compared to the positive control. This is a very novel result because it is the first time that such an effective treatment has been found. The biggest seed number per fruit was obtained for the saccharose treatment. Treatments did not significantly influence yield or fruit quality. These results are entirely consistent with a previous study that evaluated the effect of the same products on pollen tube growth, and they can help to develop new techniques. Nevertheless, more studies are necessary to test, for example, different treatment doses. + Copyright: © 2022 Garmendia et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Garmendia + Alfonso + A + + Instituto Agroforestal Mediterráneo, Universitat Politècnica de València, Valencia, Spain. + + + + Raigón + María Dolores + MD + + Instituto de Conservación y Mejora de la Agrobiodiversidad Valenciana/Departamento de Química, Universitat Politècnica de València, Valencia, Spain. + + + + García-Breijo + Francisco + F + + Departamento de Ecosistemas Agroforestales, Universitat Politècnica de València, Valencia, Spain. + + + + Reig + José + J + + Instituto Cavanilles de Biodiversidad y Biología Evolutiva, Universidad de Valencia, Valencia, Spain. + + + + Beltrán + Roberto + R + + Departamento de Ecosistemas Agroforestales, Universitat Politècnica de València, Valencia, Spain. + + + + Zornoza + Carlos + C + + S.A. Explotaciones Agrícolas Serrano (SAEAS), Valencia, Spain. + + + + Cebrián + Nuria + N + + Departamento de Ecosistemas Agroforestales, Universitat Politècnica de València, Valencia, Spain. + + + + Merle + Hugo + H + https://orcid.org/0000-0002-0004-7162 + + Departamento de Ecosistemas Agroforestales, Universitat Politècnica de València, Valencia, Spain. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 06 + 14 + + + 2022 + 11 + 23 + + + 2022 + 12 + 9 + 13 + 34 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490267 + 10.1371/journal.pone.0278934 + PONE-D-22-16769 + + +
+ + + 36490257 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Incidence of major depressive disorder over time in patients with liver cirrhosis: A nationwide population-based study in Korea. + + e0278924 + + 10.1371/journal.pone.0278924 + + There is yet to be a large-scale longitudinal study on the course of depression incidence within the duration of cirrhosis. The aim of this study is to analyze the incidence of depression from before to after diagnosis of cirrhosis over time. Incidence Rate (IR) was defined as the number of newly diagnosed patients with MDD divided by the sum of observation periods by using claims database in Korea. Incidence Rate Ratio (IRR) was defined as the IR in the specific interest period divided by the IR in the control period. The control period was defied as 1 to 2 years before diagnosis of cirrhosis. The IRs before and after cirrhosis diagnosis were 3.56 and 7.54 per 100 person-year, respectively. The IRR was 2.12 (95% confidence Interval: 2.06-2.18). The IRR of developing depression mildly increased before diagnosis of cirrhosis (-360 days to -181 days, IRR 1.14, p < 0.001; -180 days to -90 days, IRR 1.24, p < 0.001; -90 days to -31 days, IRR 1.56, p < 0.001) and rapidly increased immediately after diagnosis of cirrhosis (+30 days to +89 days, IRR 2.12, 95% confidence interval: 2.06-2.18, p < 0.001). The pattern of increasing depression immediately after the diagnosis of cirrhosis was observed equally in all sexes and ages. Thus, clinicians must pay close attention to screening for depression within the first three months of liver cirrhosis diagnosis. + Copyright: © 2022 Seo, Yoo. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Seo + Gi Hyeon + GH + https://orcid.org/0000-0001-7414-0258 + + Health Insurance Review and Assessment Service, Wonju, South Korea. + + + + Yoo + Jeong-Ju + JJ + https://orcid.org/0000-0002-7802-0381 + + Department of Gastroenterology and Hepatology, Soonchunhyang University School of Medicine, Bucheon, South Korea. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 08 + 29 + + + 2022 + 11 + 23 + + + 2022 + 12 + 9 + 13 + 34 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490257 + 10.1371/journal.pone.0278924 + PONE-D-22-24164 + + +
+ + + 36490261 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Descriptive epidemiology of hospitalized patients with bacterial nosocomial pneumonia who experience 30-day readmission in the US, 2014-2019. + + e0276192 + + 10.1371/journal.pone.0276192 + + Nosocomial pneumonia (NP) remains associated with excess morbidity and mortality. The effect of NP on measures such as re-admission at 30 days remains unclear. Moreover, differing types of NP may have varying impacts on re-admissions. + We conducted a multicenter retrospective cohort study within the Premier Research database, a source containing administrative, pharmacy, and microbiology data. We compared NP patients readmitted with pneumonia (RaP) as the principal diagnosis to those readmitted for other reasons (RaO) with respect to the type of NP (ventilator-associated bacterial pneumonia [VABP], ventilated hospital-acquired bacterial pneumonia [vHABP], and non-ventilated HABP [nvHABP]), and characteristics and outcomes of the index hospitalization. + Among 17,819 patients with NP, 14,123 (79.3%) survived to discharge, of whom 2,151 (15.2%) required an acute readmission within 30 days of index discharge. Of these, 106 (4.9%) were RaP, and the remainder were RaO. At index hospitalization, RaP patients were older (mean age [SD] 67.4 (13.9] vs. 63.0 [15.2] years), more likely medical (44.3% vs. 36.7%), and less chronically ill (median [IQR] Charlson scores (3 [2-5] vs. 4 [2-5]) than persons with RaO. Bacteremia (10.4% vs. 17.5%), need for vasopressors (15.1% vs. 20.0%), dialysis (9.4% vs. 16.5%), and/or sepsis (9.4% vs. 16.5%) or septic shock 14.2% vs. 17.1%) occurred less frequently in the RaP group. With respect to NP type, nvHABP was most common in RaP (47.2%) and VABP in RaO (38.1%). + One in seven survivors of a hospitalization complicated by NP requires an acute rehospitalization within 30 days. However, few of these readmissions had a principal diagnosis of pneumonia, irrespective of NP type. Of the 5% of NP subjects with RaP, the plurality initially suffered from nvHABP. + Copyright: © 2022 Zilberberg et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Zilberberg + Marya D + MD + https://orcid.org/0000-0002-7266-9761 + + EviMed Research Group, LLC, Goshen, MA, United States of America. + + + + Nathanson + Brian H + BH + + OptiStatim, LLC, Longmeadow, MA, United States of America. + + + + Puzniak + Laura A + LA + + Merck & Co., Inc., Kenilworth, NJ, United States of America. + + + + Zilberberg + Noah W D + NWD + + EviMed Research Group, LLC, Goshen, MA, United States of America. + + + Universty of Massachusetts, Amherst, MA, United States of America. + + + + Shorr + Andrew F + AF + + Washington Hospital Center, Washington, DC, United States of America. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + I have read the journal’s policy. In addition to funding statement above, the following potential competing interest exist: •MDZ and AFS have received grant support and/or have served as consultants to Lungpacer, Melinta, Tetraphase, Pfizer, Astellas, Shionogi, The Medicines Company, Spero, and Theravance. +
+ + + + 2022 + 01 + 13 + + + 2022 + 09 + 30 + + + 2022 + 12 + 9 + 13 + 34 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490261 + 10.1371/journal.pone.0276192 + PONE-D-22-01197 + + +
+ + + 36490262 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Frameworks for mitigating the risk of waterborne diarrheal diseases: A scoping review. + + e0278184 + + 10.1371/journal.pone.0278184 + + Diarrhea is one of the major cause of death and morbidity around the world. + This scoping review summarizes existing frameworks that aim to mitigate the risks of waterborne diarrheal diseases and describe the strengths and weaknesses of these frameworks. + Published frameworks designed to mitigate the risks of waterborne diarrheal diseases. Frameworks published in English, from around the world and published since inception to date. + PubMed, Scopus, Web of Science, Google Scholar, Google Free Search, organization websites and reference lists of identified sources. + Data were charted using the Joanna Briggs Institute tool. Results were summarized and described narratively. A criterion to score the strengths and weaknesses of the included frameworks was also developed. + Five frameworks were identified including: the hygiene improvement framework, community led total sanitation, global action plan for pneumonia and diarrhea, participatory hygiene and sanitation transformation, and sanitation and family education. These frameworks shared several common components, including identification of problems and risk factors, identification and implementation of interventions, and evaluation and monitoring. The frameworks had several interventions including different infrastructure, health promotion and education, enabling environment and clinical treatments. Most of the frameworks included health promotion and education. All the frameworks were strengthened by including strategies for implementing and delivering intervention, human resource aspect, community involvement, monitoring, and evaluation. The main weakness included not having components for collecting, storing, and transferring electronic data and the frameworks not being specifically for mitigating waterborne diarrheal diseases. In addition, the identified frameworks were found to be effective in mitigating the risk of diarrhea diseases among other health effects. + Existing frameworks should be updated specifically for mitigating waterborne diarrheal diseases that includes the strengths and addresses weaknesses of reviewed frameworks. + Copyright: © 2022 Meki et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Meki + Chisala D + CD + https://orcid.org/0000-0002-2977-2288 + + School of Public Health, University of Zambia, Lusaka, Zambia. + + + Faculty of Health Sciences, School of Health Systems and Public Health, University of Pretoria, Pretoria, South Africa. + + + + Ncube + Esper J + EJ + https://orcid.org/0000-0003-0899-3871 + + Faculty of Health Sciences, School of Health Systems and Public Health, University of Pretoria, Pretoria, South Africa. + + + Rand Water, Johannesburg, South Africa. + + + + Voyi + Kuku + K + + Faculty of Health Sciences, School of Health Systems and Public Health, University of Pretoria, Pretoria, South Africa. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 05 + 19 + + + 2022 + 11 + 11 + + + 2022 + 12 + 9 + 13 + 34 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490262 + 10.1371/journal.pone.0278184 + PONE-D-22-14568 + + +
+ + + 36490264 + + 2022 + 12 + 09 + +
+ + 2327-6924 + + + 2022 + Dec + 09 + + + Journal of the American Association of Nurse Practitioners + J Am Assoc Nurse Pract + + Improving screening for major depressive disorder. + 10.1097/JXX.0000000000000817 + + Depression affects up to 20% of primary care patients and negatively affects patients' mental and physical health. + At a primary care clinic, a review of 291 patient records revealed that no patients were being screened for depression using a validated and reliable tool. + The problem was addressed through the implementation of a depression screening and management protocol based on the U.S. Preventive Services Task Force guidelines. Processes used were recommended by the American College of Preventive Medicine and Institute for Clinical Systems Improvement. + This project implemented a protocol to screen, treat, and manage patients with depression at this primary care clinic. Analysis compared preimplementation and postimplementation metrics, including the number of patients screened for depression, newly diagnosed with depression, offered antidepressants, offered referral, and managed with follow-up. + Implementing a depression screening and management protocol in this clinic significantly increased depression screenings, the percent of patients newly diagnosed with depression, and the number of patients offered treatment. + This quality improvement (QI) project improved screening, diagnosis, and management of patients with depression in this primary care clinic. A future QI project for this clinic should focus on measures to track improvements in patients with depression at this primary care clinic. + Copyright © 2022 American Association of Nurse Practitioners. + + + + Sharp + Lauren K + LK + 0000-0002-8769-0520 + + NextCare Urgent Care, Dumfries, Virginia. + + + + Montgomery + Susan L + SL + + Community/Mental Health Nursing, College of Nursing, University of South Alabama, Mobile, Alabama. + + + + Williams + Russell W + RW + + Stafford Primary Care Associates, Stafford, Virginia. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + J Am Assoc Nurse Pract + 101600770 + 2327-6886 + + Competing interests: The authors report no conflicts of interest. +
+ + + + 2022 + 04 + 08 + + + 2022 + 11 + 11 + + + 2022 + 12 + 9 + 13 + 34 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36490264 + 10.1097/JXX.0000000000000817 + 01741002-990000000-00068 + + + + Akincigil A., Matthew E. B. (2017). National rates and patterns of depression screening in primary care: Results from 2012 and 2013. Psychiatric Services, 68(7), 660–666. https://doi.org/10.1176/appi.ps.201600096 + + 10.1176/appi.ps.201600096 + + + + Arroll B., Chin W., Martis W., Goodyear-Smith F., Mount V., Kingsford D., Humm S., Blashki G., MacGilllivray S. (2016). Antidepressants for treatment of depression in primary care: A systematic review and meta-analysis. Journal of Primary Health Care, 8(4), 325–334. https://doi.org/10.1071/hc16008 + + 10.1071/hc16008 + + + + Bajracharya P., Summers L., Amatya A. K., DeBlieck C. (2016). Implementation of a depression screening protocol and tools to improve screening for depression in patients with diabetes in the primary care setting. The Journal for Nurse Practitioners, 12(10), 690–696. https://doi.org/10.1016/j.nurpra.2016.08.009 + + 10.1016/j.nurpra.2016.08.009 + + + + Ferenchick E. K., Ramanuj P., Pincus H. A. (2019). Depression in primary care: Part 1 – screening and diagnosis. BMJ, 365, l794. https://doi.org/10.1136/bmj.l794 + + 10.1136/bmj.l794 + + + + Hall H. R., Roussel L. A. (2017). Evidence-based practice: An integrative approach to research, administration, and practice (2nd ed.). Jones & Bartlett Learning. + + + Jackson W. C., Thase M. E. (2021). Setting the stage for major depressive disorder recovery: Strategies for the busy primary care provider. The Journal of Family Medicine, 70(1), S1–S19. https://doi.org/10.12788/jfp.0134 + + 10.12788/jfp.0134 + + + + Keller A. O., Valdes C. R., Schwei R. J., Jacobs E. A. (2016). Disclosure of depression in primary care: A qualitative study of women's perceptions. Women’s Health Issues, 25(5), 529–536. https://doi.org/10.1016/j.whi.2016.07.002 + + 10.1016/j.whi.2016.07.002 + + + + Kroenke K., Spitzer R. L., Williams J. B. W. (2003). The patient health questionnaire-2: Validity of a two-item depression screener. Medical Care, 41(11), 1284–1292. https://doi.org/10.1097/01.mlr.0000093487.78664.3c + + 10.1097/01.mlr.0000093487.78664.3c + + + + Kroenke K., Spitzer R. L., Williams J. B. W. (2001). The PHQ-9: Validity of a brief depression severity measure. Journal of General Internal Medicine, 16(9), 606–613. https://doi.org/10.1046/j.1525-1497.2001.016009606.x + + 10.1046/j.1525-1497.2001.016009606.x + + + + Moise N., Falzon L., Obi M., Ye S., Patel S., Gonzalez C., Bryant K., Kronish I. M. (2018). Interventions to increase depression treatment initiation in primary care patients: A systematic review. Journal of General Internal Medicine, 33(11), 1978–1989. https://doi.org/10.1007/s11606-018-4554-z + + 10.1007/s11606-018-4554-z + + + + Moran K., Burson R., Conrad D. (2020). The doctor of nursing practice project: A framework for success (3rd. Ed.). Jones & Bartlett Learning. + + + Mulrow C. D., Williams J. W., Gerety M. B., Ramirez G., Montiel O. M., Kerber C. (1995). Case-finding instruments in depression in primary care settings. Annals of Internal Medicine, 122(12), 913–921. https://doi.org/10.7326/0003-4819-122-12-199506150-00004 + + 10.7326/0003-4819-122-12-199506150-00004 + + + + Nimalasuriya K., Compton M. T., Guillory V. J. (2009). Screening adults for depression in primary care: A position statement of the American College of preventive Medicine. The Journal of Family Practice, 58(10), 535–538. https://www.mdedge.com/familymedicine/article/63746/mental-health/screening-adults-depression-primary-care-position + + + Parikh S. V., Quilty L. C., Ravitz P., Rosenbluth M., Pavlova B., Grigoriadis S., Velyvis V., Kennedy S. H., Lam R. W., MacQueen G. M., Milev R. V., Ravindram A. V., Uher R., & the CANMAT Depression Work Group. (2016). Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 clinical guidelines for the management of adults with major depressive disorder: Section 2. psychological treatments. The Canadian Journal of Psychiatry, 61(9), 524–539. https://doi.org/10.1177/0706743716659418 + + 10.1177/0706743716659418 + + + + Posner K., Brown G. K., Stanley B., Brent D. A., Yershova K. V., Oquendo M. A., Currier G. W., Melvin G. A., Greenhill L., Shen S., Mann J. J. (2011). The Columbia-Suicide Severity Rating Scale: Initial validity and internal consistency findings from three multisite studies with adolescents and adults. American Journal of Psychiatry, 168(12), 1266–1277. https://doi.org/10.1176/appi.ajp.2011.10111704 + + 10.1176/appi.ajp.2011.10111704 + + + + Ramanuj P., Ferenchick E. F., Pincus H. A. (2019). Depression in primary care: Part 2 – management. BMJ, 365, l835. https://doi.org/10.1136/bmj.l835 + + 10.1136/bmj.l835 + + + + Siu A. L., & US Preventive Services Task Force. (2016). Screening for depression in adults: US preventive Services Task Force recommendation. JAMA, 315(4), 380–387. https://doi.org/10.1001/jama.2015.18392 + + 10.1001/jama.2015.18392 + + + + Trangle M., Gursky J., Haight R., Hardwig J., Hinnenkamp T., Kessler D., Mack N., Myszkowski M. (2016, March). Adult Depression in Primary Care. Institute for Clinical Systems Improvement. https://www.icsi.org/wp-content/uploads/2019/01/Depr.pdf + + + Zaccagnini M. E., White K. W. (2017). The doctor of nursing practice essentials: A new model for advanced practice nursing (3rd ed.). Jones & Bartlett Learning. + + + +
+ + + 36490265 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + A quality improvement study on the relationship between intranasal povidone-iodine and anesthesia and the nasal microbiota of surgery patients. + + e0278699 + + 10.1371/journal.pone.0278699 + + The composition of the nasal microbiota in surgical patients in the context of general anesthesia and nasal povidone-iodine decolonization is unknown. The purpose of this quality improvement study was to determine: (i) if general anesthesia is associated with changes in the nasal microbiota of surgery patients and (ii) if preoperative intranasal povidone-iodine decolonization is associated with changes in the nasal microbiota of surgery patients. + One hundred and fifty-one ambulatory patients presenting for surgery were enrolled in a quality improvement study by convenience sampling. Pre- and post-surgery nasal samples were collected from patients in the no intranasal decolonization group (control group, n = 54). Pre-decolonization nasal samples were collected from the preoperative intranasal povidone-iodine decolonization group (povidone-iodine group, n = 97). Intranasal povidone-iodine was administered immediately prior to surgery and continued for 20 minutes before patients proceeded for surgery. Post-nasal samples were then collected. General anesthesia was administered to both groups. DNA from the samples was extracted for 16S rRNA sequencing on an Illumina MiSeq. + In the control group, there was no evidence of change in bacterial diversity between pre- and post-surgery samples. In the povidone-iodine group, nasal bacterial diversity was greater in post-surgery, relative to pre-surgery (Shannon's Diversity Index (P = 0.038), Chao's richness estimate (P = 0.02) and Inverse Simpson index (P = 0.027). Among all the genera, only the relative abundance of the genus Staphylococcus trended towards a decrease in patients after application (FDR adjusted P = 0.06). Abundant genera common to both povidone-iodine and control groups included Staphylococcus, Bradyrhizobium, Corynebacterium, Dolosigranulum, Lactobacillus, and Moraxella. + We found general anesthesia was not associated with changes in the nasal microbiota. Povidone-iodine treatment was associated with nasal microbial diversity and decreased abundance of Staphylococcus. Future studies should examine the nasal microbiota structure and function longitudinally in surgical patients receiving intranasal povidone-iodine. + Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. + + + + Hammond + Eric N + EN + https://orcid.org/0000-0003-2239-0727 + + Institute for Clinical and Translational Research, University of Wisconsin-Madison, Madison, WI, United States of America. + + + Division of Infectious Disease, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States of America. + + + + Kates + Ashley E + AE + + Division of Infectious Disease, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States of America. + + + William S. Middleton Memorial Veterans Hospital, Madison, WI, United States of America. + + + + Putman-Buehler + Nathan + N + https://orcid.org/0000-0003-2398-2265 + + Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin-Madison, Madison, WI, United States of America. + + + + Watson + Lauren + L + + SSM Health, St. Mary's Hospital, Madison, WI, United States of America. + + + + Godfrey + Jared J + JJ + + Division of Infectious Disease, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States of America. + + + William S. Middleton Memorial Veterans Hospital, Madison, WI, United States of America. + + + + Brys + Nicole + N + + Waisman Center, University of Wisconsin-Madison, Madison, WI, United States of America. + + + + Deblois + Courtney + C + https://orcid.org/0000-0002-1049-7212 + + Department of Bacteriology, University of Wisconsin-Madison, Madison, WI, United States of America. + + + Microbiology Doctoral Training Program, University of Wisconsin-Madison, Madison, WI, United States of America. + + + + Steinberger + Andrew J + AJ + + Department of Bacteriology, University of Wisconsin-Madison, Madison, WI, United States of America. + + + Microbiology Doctoral Training Program, University of Wisconsin-Madison, Madison, WI, United States of America. + + + + Cox + Madison S + MS + https://orcid.org/0000-0001-7092-2754 + + Department of Bacteriology, University of Wisconsin-Madison, Madison, WI, United States of America. + + + Microbiology Doctoral Training Program, University of Wisconsin-Madison, Madison, WI, United States of America. + + + + Skarlupka + Joseph H + JH + + Department of Bacteriology, University of Wisconsin-Madison, Madison, WI, United States of America. + + + Microbiology Doctoral Training Program, University of Wisconsin-Madison, Madison, WI, United States of America. + + + + Haleem + Ambar + A + + Division of Infectious Disease, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States of America. + + + + Bentz + Michael L + ML + + Division of Plastic and Reconstructive Surgery and Urology, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States of America. + + + + Suen + Garret + G + + Department of Bacteriology, University of Wisconsin-Madison, Madison, WI, United States of America. + + + + Safdar + Nasia + N + + Division of Infectious Disease, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States of America. + + + William S. Middleton Memorial Veterans Hospital, Madison, WI, United States of America. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 07 + 28 + + + 2022 + 11 + 22 + + + 2022 + 12 + 9 + 13 + 34 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490265 + 10.1371/journal.pone.0278699 + PONE-D-22-21286 + + +
+ + + 36490260 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Diversity matters in wheat mixtures: A genomic survey of the impact of genetic diversity on the performance of 12 way durum wheat mixtures grown in two contrasted and controlled environments. + + e0276223 + + 10.1371/journal.pone.0276223 + + In ecology, an increase in genetic diversity within a community in natural ecosystems increases its productivity, while in evolutionary biology, kinship selection predicts that relatedness on social traits improves fitness. Varietal mixtures, where different genotypes are grown together, show contrasting results, especially for grain yield where both positive and negative effects of mixtures have been reported. To understand the effect of diversity on field performance, we grew 96 independent mixtures each composed with 12 durum wheat (Triticum turgidum ssp. durum Thell.) inbred lines, under two contrasting environmental conditions for water availability. Using dense genotyping, we imputed allelic frequencies and a genetic diversity index on more than 96000 loci for each mixture. We then analyzed the effect of genetic diversity on agronomic performance using a genome-wide approach. We explored the stress gradient hypothesis, which proposes that the greater the unfavourable conditions, the more beneficial the effect of diversity on mixture performance. We found that diversity on average had a negative effect on yield and its components while it was beneficial on grain weight. There was little support for the stress gradient theory. We discuss how to use genomic data to improve the assembly of varietal mixtures. + Copyright: © 2022 Alsabbagh et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Alsabbagh + Pauline + P + https://orcid.org/0000-0001-7433-8248 + + UMR AGAP, CIRAD, INRAE, Institut Agro Montpellier, Université Montpellier, Montpellier, France. + + + + Gay + Laurène + L + + UMR AGAP, CIRAD, INRAE, Institut Agro Montpellier, Université Montpellier, Montpellier, France. + + + + Colombo + Michel + M + + UMR AGAP, CIRAD, INRAE, Institut Agro Montpellier, Université Montpellier, Montpellier, France. + + + + Montazeaud + Germain + G + + Department of Ecology and Evolution, University of Lausanne, Lausanne, Switzerland. + + + + Ardisson + Morgane + M + + UMR AGAP, CIRAD, INRAE, Institut Agro Montpellier, Université Montpellier, Montpellier, France. + + + + Rocher + Aline + A + + UMR AGAP, CIRAD, INRAE, Institut Agro Montpellier, Université Montpellier, Montpellier, France. + + + + Allard + Vincent + V + + UMR GDEC, INRAE, Université Clermont Auvergne, Clermont-Ferrand, France. + + + + David + Jacques L + JL + + UMR AGAP, CIRAD, INRAE, Institut Agro Montpellier, Université Montpellier, Montpellier, France. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors declare no competing interest. +
+ + + + 2021 + 11 + 03 + + + 2022 + 10 + 04 + + + 2022 + 12 + 9 + 13 + 34 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490260 + 10.1371/journal.pone.0276223 + PONE-D-21-35051 + + +
+ + + 36490268 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + The impact of modifier genes on cone-rod dystrophy heterogeneity: An explorative familial pilot study and a hypothesis on neurotransmission impairment. + + e0278857 + + 10.1371/journal.pone.0278857 + + Cone-rod dystrophies (CORDs) are a heterogeneous group of inherited retinopathies (IRDs) with more than 30 already known disease-causing genes. Uncertain phenotypes and extended range of intra- and interfamilial heterogenicity make still difficult to determine a precise genotype-phenotype correlation. Here, we used a next-generation sequencing approach to study a Sicilian family with a suspected form of CORD. Affected family members underwent ophthalmological examinations and a proband, blind from 50 years, underwent whole genome and exome sequencing. Variant analysis was enriched by pathway analysis and relevant variants were, then, investigated in other family members and in 100 healthy controls from Messina. CORD diagnosis with an intricate pattern of symptoms was confirmed by ophthalmological examinations. A total of about 50,000 variants were identified in both proband's genome and exome. All affected family members presented specific genotypes mainly determined by mutated GUCY2D gene, and different phenotypical traits, mainly related to focus and color perception. Thus, we looked for possible modifier genes. According to relationship with GUCY2D, predicted functional effects, eye localization, and ocular disease affinity, only 9 variants, carried by 6 genes (CACNG8, PAX2, RXRG, CCDC175, PDE4DIP and LTF), survived the filtering. These genes encode key proteins involved in cone development and survival, and retina neurotransmission. Among analyzed variants, CACNG8c.*6819A>T and the new CCDC175 c.76C>T showed extremely low frequency in the control group, suggesting a key role on disease phenotypes. Such discovery could enforce the role of modifier genes into CORD onset/progression, contributing to improve diagnostic test towards a better personalized medicine. + Copyright: © 2022 Donato et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Donato + Luigi + L + + Division of Medical Biotechnologies and Preventive Medicine, Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy. + + + Department of Biomolecular Strategies, Genetics, Cutting-Edge Therapies, I.E.ME.S.T., Palermo, Italy. + + + + Alibrandi + Simona + S + + Division of Medical Biotechnologies and Preventive Medicine, Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy. + + + Department of Biomolecular Strategies, Genetics, Cutting-Edge Therapies, I.E.ME.S.T., Palermo, Italy. + + + Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy. + + + + Scimone + Concetta + C + https://orcid.org/0000-0002-4824-1693 + + Division of Medical Biotechnologies and Preventive Medicine, Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy. + + + Department of Biomolecular Strategies, Genetics, Cutting-Edge Therapies, I.E.ME.S.T., Palermo, Italy. + + + + Rinaldi + Carmela + C + + Division of Medical Biotechnologies and Preventive Medicine, Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy. + + + + Dascola + Angela + A + + Division of Medical Biotechnologies and Preventive Medicine, Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy. + + + + Calamuneri + Alessandro + A + https://orcid.org/0000-0003-3164-6464 + + Division of Medical Biotechnologies and Preventive Medicine, Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy. + + + + D'Angelo + Rosalia + R + + Division of Medical Biotechnologies and Preventive Medicine, Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy. + + + + Sidoti + Antonina + A + + Division of Medical Biotechnologies and Preventive Medicine, Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 09 + 06 + + + 2022 + 11 + 23 + + + 2022 + 12 + 9 + 13 + 34 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490268 + 10.1371/journal.pone.0278857 + PONE-D-22-24836 + + +
+ + + 36490271 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Attitude and level of COVID-19 vaccination and its determinants among patients with chronic disease visiting Debre Tabor Comprehensive Specialized Hospital, Northwest Ethiopia: A cross-sectional study. + + e0278914 + + 10.1371/journal.pone.0278914 + + Coronavirus disease is a fatal viral disease caused by severe acute respiratory syndrome coronavirus 2. This study was aimed to assess the attitude, level of COVID-19 vaccine uptake, and its determinants among patients with chronic diseases visiting Debre Tabor Comprehensive Specialized Hospital, Northwest Ethiopia. + An institutional-based cross-sectional study was conducted among 422 randomly selected patients with chronic disease visiting Debre Tabor Comprehensive Specialized Hospital from February 1 to March 30, 2022. Bivariable and multivariable binary logistic regression analyses were done to identify associations between dependent and independent variables. + Among all participants, only 29.6% of patients were vaccinated with any of the COVID-19 vaccines at least one dose. Age from 31 to 40 years (AOR = 6.26, 95% CI: 2.69-14.56), attended collage and above (AOR = 6.3, 95% CI: 1.37, 28.68), positive attitude towards COVID-19 vaccine (AOR = 9.07, 95% CI: 4.51-18.22), good knowledge (AOR = 7.63, 95% CI: 1.08-16.85), history of COVID-19 (AOR = 4.33, 95% CI: 1.85-10.17), family history of COVID-19 (AOR = 3.99, 95% CI = 1.89-8.48), ever been tested for COVID-19 (AOR = 0.33, 95% CI: 0.15-0.74) were determinant factors for COVID-19 vaccine uptake. + COVID-19 vaccine uptake among patients with chronic disease was very low. The main reasons for not being vaccinated were doubts about vaccine efficacy, the vaccine may cause disease by itself, and fear of adverse effects. Therefore, different stakeholders should enforce vaccine uptake and awareness creation. + Copyright: © 2022 Dagnew Baye et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Dagnew Baye + Nega + N + + Department of Biomedical Sciences, College of Health Sciences, Debre Tabor University, Debretabor, Ethiopia. + + + + Agegnehu Teshome + Assefa + A + + Department of Biomedical Sciences, College of Health Sciences, Debre Tabor University, Debretabor, Ethiopia. + + + + Agimas Ayenew + Atalo + A + + Department of Biomedical Sciences, College of Health Sciences, Debre Tabor University, Debretabor, Ethiopia. + + + + Tilahun Mulu + Anmut + A + + Department of Biomedical Sciences, College of Health Sciences, Debre Tabor University, Debretabor, Ethiopia. + + + + Chekol Abebe + Endeshaw + E + + Department of Biomedical Sciences, College of Health Sciences, Debre Tabor University, Debretabor, Ethiopia. + + + + Tilahun Muche + Zelalem + Z + + Department of Biomedical Sciences, College of Health Sciences, Debre Tabor University, Debretabor, Ethiopia. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 06 + 28 + + + 2022 + 11 + 23 + + + 2022 + 12 + 9 + 13 + 34 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490271 + 10.1371/journal.pone.0278914 + PONE-D-22-18385 + + +
+ + + 36490263 + + 2022 + 12 + 09 + +
+ + 1935-5548 + + + 2022 + Dec + 09 + + + Diabetes care + Diabetes Care + + Association of Serum Uric Acid With All-Cause and Cardiovascular Mortality in Diabetes. + dc221339 + 10.2337/dc22-1339 + + To investigate whether serum uric acid (SUA) level is associated with all-cause and cardiovascular disease (CVD) mortality among individuals with diabetes. + In this prospective cohort study, we included patients with diabetes from the U.S. National Health and Nutritional Examination Survey (NHANES) 1999-2018. Mortality and underlying causes of death were ascertained by linkage to national death records through 31 December 2019. Weighted Cox proportional hazards regression models were used to evaluate hazard ratios (HRs) and 95% CIs for all-cause and CVD mortality. We also performed a meta-analysis of available cohort studies to combine the association between SUA level and mortality in diabetes. + Among the 7,101 patients with diabetes from NHANES 1999-2018, the weighted mean of SUA level was 5.7 mg/dL. During 57,926 person-years of follow-up, 1,900 deaths (n = 674 deaths from CVD) occurred. In the fully adjusted model, when compared with patients with diabetes in the lowest SUA quintile, those in the highest SUA quintile had the HRs (95% CIs) of 1.28 (1.03, 1.58) for all-cause mortality and 1.41 (1.03, 1.94) for CVD mortality. We included 13 cohort studies in the meta-analysis and found that the pooled HRs (95% CIs) were 1.08 (1.05, 1.11) for all-cause mortality and 1.05 (1.03, 1.06) for CVD mortality per 1 mg/dL increment of SUA level in patients with diabetes. + This study indicated that higher SUA levels were associated with increased risks of all-cause and CVD mortality in diabetes. Interventional studies are needed to elucidate the health effect of treatments to lower SUA levels. + © 2022 by the American Diabetes Association. + + + + Li + Benchao + B + + Department of Nutrition, Hygiene, and Toxicology, Academy of Nutrition and Health, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Public Health, Medical College, Wuhan University of Science and Technology, Wuhan 430065, China. + + + + Chen + Liangkai + L + 0000-0002-5227-4236 + + Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. + + + + Hu + Xueting + X + + Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. + + + + Tan + Ting + T + + Department of Nutrition, Hygiene, and Toxicology, Academy of Nutrition and Health, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Public Health, Medical College, Wuhan University of Science and Technology, Wuhan 430065, China. + + + + Yang + Jiajia + J + + Department of Nutrition, Hygiene, and Toxicology, Academy of Nutrition and Health, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Public Health, Medical College, Wuhan University of Science and Technology, Wuhan 430065, China. + + + + Bao + Wei + W + + Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China. + + + + Rong + Shuang + S + 0000-0002-8363-0862 + + Department of Nutrition, Hygiene, and Toxicology, Academy of Nutrition and Health, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Public Health, Medical College, Wuhan University of Science and Technology, Wuhan 430065, China. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + Diabetes Care + 7805975 + 0149-5992 + + IM +
+ + + + 2022 + 07 + 07 + + + 2022 + 11 + 01 + + + 2022 + 12 + 9 + 13 + 34 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36490263 + 148069 + 10.2337/dc22-1339 + + +
+ + + 36490256 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Household food insecurity risk indices for English neighbourhoods: Measures to support local policy decisions. + + e0267260 + + 10.1371/journal.pone.0267260 + + In England, the responsibility to address food insecurity lies with local government, yet the prevalence of this social inequality is unknown in small subnational areas. In 2018 an index of small-area household food insecurity risk was developed and utilised by public and third sector organisations to target interventions; this measure needed updating to better support decisions in different settings, such as urban and rural areas where pressures on food security differ. + We held interviews with stakeholders (n = 14) and completed a scoping review to identify appropriate variables to create an updated risk measure. We then sourced a range of open access secondary data to develop an indices of food insecurity risk in English neighbourhoods. Following a process of data transformation and normalisation, we tested combinations of variables and identified the most appropriate data to reflect household food insecurity risk in urban and rural areas. + Eight variables, reflecting both household circumstances and local service availability, were separated into two domains with equal weighting for a new index, the Complex Index, and a subset of these to make up the Simple Index. Within the Complex Index, the Compositional Domain includes population characteristics while the Structural Domain reflects small area access to resources such as grocery stores. The Compositional Domain correlated well with free school meal eligibility (rs = 0.705) and prevalence of childhood obesity (rs = 0.641). This domain was the preferred measure for use in most areas when shared with stakeholders, and when assessed alongside other configurations of the variables. Areas of highest risk were most often located in the North of England. + We recommend the use of the Compositional Domain for all areas, with inclusion of the Structural Domain in rural areas where locational disadvantage makes it more difficult to access resources. These measures can aid local policy makers and planners when allocating resources and interventions to support households who may experience food insecurity. + Copyright: © 2022 Smith et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Smith + Dianna M + DM + https://orcid.org/0000-0002-0650-6606 + + School of Geography and Environmental Science, University of Southampton, Southampton, United Kingdom. + + + NIHR Applied Research Collaboration Wessex, Southampton, United Kingdom. + + + + Rixson + Lauren + L + + School of Geography and Environmental Science, University of Southampton, Southampton, United Kingdom. + + + + Grove + Grace + G + + NIHR Applied Research Collaboration Wessex, Southampton, United Kingdom. + + + School of Primary Care, Population Sciences and Medical Education, Faculty of Medicine, University of Southampton, Southampton, United Kingdom. + + + + Ziauddeen + Nida + N + https://orcid.org/0000-0002-8964-5029 + + NIHR Applied Research Collaboration Wessex, Southampton, United Kingdom. + + + School of Primary Care, Population Sciences and Medical Education, Faculty of Medicine, University of Southampton, Southampton, United Kingdom. + + + + Vassilev + Ivaylo + I + + School of Health Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, United Kingdom. + + + + Taheem + Ravita + R + + Southampton City Council, Southampton, United Kingdom. + + + + Roderick + Paul + P + + NIHR Applied Research Collaboration Wessex, Southampton, United Kingdom. + + + School of Primary Care, Population Sciences and Medical Education, Faculty of Medicine, University of Southampton, Southampton, United Kingdom. + + + + Alwan + Nisreen A + NA + + NIHR Applied Research Collaboration Wessex, Southampton, United Kingdom. + + + School of Primary Care, Population Sciences and Medical Education, Faculty of Medicine, University of Southampton, Southampton, United Kingdom. + + + NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 04 + 04 + + + 2022 + 11 + 25 + + + 2022 + 12 + 9 + 13 + 34 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490256 + 10.1371/journal.pone.0267260 + PONE-D-22-09936 + + +
+ + + 36490269 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Barbell load distribution and lifting velocity affect bench press exercise volume and perceived exertion. + + e0278909 + + 10.1371/journal.pone.0278909 + + The intensity of barbell bench press exercise is generally prescribed as the load to be lifted for a specific number of repetitions; however, other factors (e.g., execution velocity) can affect bench press exercise intensity. Moreover, no study assessed whether load distribution (i.e., the distance between the disc stacks on the two sides of the barbell) affects exercise intensity. The present study aims to assess how different combinations of load, velocity, and barbell load distribution affect the number of repetitions to failure (REPfailure), and rating of perceived exertion (RPEfatigue) and number of repetitions (REPfatigue) at fatigue onset. + Ten males (age 23.3±1.8 years) performed bench press exercises to exhaustion using random combinations of three loads (50%, 65%, and 80% of 1 repetition maximum), three execution velocities (50%, 70%, and 90% of maximal concentric velocity), and two load distributions (narrow and wide). Three separate three-way repeated-measures ANOVAs were performed to assess the effect of load, velocity, and load distribution on REPfailure, RPEfatigue, and REPfatigue expressed as a percentage of REPfailure. + REPfailure was affected by load (p<0.001), velocity (p<0.001), and distribution (p = 0.005). The interactions between load and velocity (p<0.001) and load and distribution (p = 0.004) showed a significant effect on REPfailure, whereas the interaction between velocity and distribution was not significant (p = 0.360). Overall, more REPfailure were performed using lower loads, higher velocities, and a wider distribution. RPEfatigue and REPfatigue were affected by load (p<0.001 and p = 0.007, respectively) and velocity (p<0.001 and p<0.001, respectively), and not by distribution (p = 0.510 and p = 0.571, respectively) or the two-way interaction effects. Overall, using higher loads yielded higher RPEfatigue but lower REPfatigue, while RPEfatigue and REPfatigue were higher when slower velocities were used. + The current investigation shows that not only load but also velocity and barbell load distribution may influence bench press training volume and perceived exertion. + Copyright: © 2022 Ferri Marini et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Ferri Marini + Carlo + C + https://orcid.org/0000-0002-6866-997X + + Department of Biomolecular Sciences, Division of Exercise and Health Sciences, University of Urbino Carlo Bo, Carlo Bo, Italy. + + + + Shoaei + Vahid + V + + Department of Biomolecular Sciences, Division of Exercise and Health Sciences, University of Urbino Carlo Bo, Carlo Bo, Italy. + + + + Micheli + Lorenzo + L + + Department of Biomolecular Sciences, Division of Exercise and Health Sciences, University of Urbino Carlo Bo, Carlo Bo, Italy. + + + + Francia + Piergiorgio + P + https://orcid.org/0000-0001-5176-1449 + + Department of Biomolecular Sciences, Division of Exercise and Health Sciences, University of Urbino Carlo Bo, Carlo Bo, Italy. + + + + Grossi + Tommaso + T + + Department of Biomolecular Sciences, Division of Exercise and Health Sciences, University of Urbino Carlo Bo, Carlo Bo, Italy. + + + + Maggio + Serena + S + https://orcid.org/0000-0001-8778-6576 + + Department of Biomolecular Sciences, Division of Exercise and Health Sciences, University of Urbino Carlo Bo, Carlo Bo, Italy. + + + + Benelli + Piero + P + + Department of Biomolecular Sciences, Division of Exercise and Health Sciences, University of Urbino Carlo Bo, Carlo Bo, Italy. + + + + Federici + Ario + A + + Department of Biomolecular Sciences, Division of Exercise and Health Sciences, University of Urbino Carlo Bo, Carlo Bo, Italy. + + + + Lucertini + Francesco + F + https://orcid.org/0000-0003-3134-4511 + + Department of Biomolecular Sciences, Division of Exercise and Health Sciences, University of Urbino Carlo Bo, Carlo Bo, Italy. + + + + Zoffoli + Luca + L + + Department of Biomolecular Sciences, Division of Exercise and Health Sciences, University of Urbino Carlo Bo, Carlo Bo, Italy. + + + Scientific Research & Innovation Department, Technogym S.p.A., Italy. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 07 + 20 + + + 2022 + 11 + 28 + + + 2022 + 12 + 9 + 13 + 34 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490269 + 10.1371/journal.pone.0278909 + PONE-D-22-20454 + + +
+ + + 36490259 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Responses of soccer players performing repeated maximal efforts in simulated conditions of the FIFA World Cup Qatar 2022: A holistic approach. + + e0276314 + + 10.1371/journal.pone.0276314 + + This study aimed to assess the capacity for repeated maximal effort (RME) of soccer players in the thermo-natural conditions (NC) and in simulated conditions for the 2022 FIFA World Cup in Qatar (QSC). Twenty-four semi-professional soccer players participated in the study. The exercise test consisted of ten 6-second maximal efforts on a cycloergometer. A 90-second passive rest interval was used. The test was performed in a Weiss Technik WK-26 climate test chamber in two different conditions: 1) thermo-neutral conditions (NC-20.5°C; 58.7% humidity); and 2) simulated conditions for the 2022 World Cup in Qatar (QSC-28.5 ± 1.92°C; 58.7 ± 8.64% humidity). Power-related, physiological, psychomotor, blood, and electrolyte variables were recorded. Results showed that (1) players achieved higher peak power (max 1607,46 ± 192,70 [W] - 3rd rep), needed less time to peak power (min 0,95 ± 0,27 [s] - 3rd rep), and had a higher fatigue slope (max 218,67 ± 59,64 [W/sek] - 7th rep) in QSC than in NC (in each repetition of study protocol); (2) between the 1st repetition and subsequent repetitions a number of significants in among physiological, blood-related, and electrolyte variables were noted, but their direction was similar in both simulated conditions (e.g. V'O2/kg 37,59 ± 3,96 vs 37,95 ± 3,17 [ml/min/kg] - 3rd rep, LAC 13,16 ± 2,61 vs 14,18 ± 3,13 [mg/dl] - 10th rep or K 4,54 ± 0,29 vs 4,79 ± 0,36 [mmol/l] - 2nd rep when compare QCS and NC respectively); (3) an 8°C of temperature difference between the climatic conditions did not significantly affect the soccer players' physical and physiological responses in RME. The study results can be used in the design of training programs aimed to increase players' physiological adaptations by simulating soccer-specific conditions of play in terms of anaerobic capacity, in particular, repetitive maximal efforts. These findings will be useful during the upcoming 2022 World Cup in Qatar and in locations where high ambient temperatures are customary. + Copyright: © 2022 Chmura et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Chmura + Paweł + P + https://orcid.org/0000-0002-4211-0393 + + Department of Team Games, Wrocław University of Health and Sport Sciences, Wrocław, Poland. + + + + Liu + Hongyou + H + + School of Physical Education & Sports Science, Guangzhou Higher Education Mega Centre, South China Normal University, Guangzhou, China. + + + + Andrzejewski + Marcin + M + https://orcid.org/0000-0002-5127-711X + + Department of Methodology of Recreation, Poznań University of Physical Education, Poznań, Poland. + + + + Tessitore + Antonio + A + + Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", Rome, Italy. + + + + Sadowski + Jerzy + J + https://orcid.org/0000-0002-1751-9613 + + Department of Sport Science, Faculty of Physical Education and Health, Józef Piłsudski University of Physical Education in Warsaw, Warsaw, Poland. + + + + Chmura + Jan + J + + Department of Human Motor Skills, Wrocław University of Health and Sport Sciences, Wrocław, Poland. + + + + Rokita + Andrzej + A + + Department of Team Games, Wrocław University of Health and Sport Sciences, Wrocław, Poland. + + + + Tański + Wojciech + W + + 4th Military Teaching Hospital with Clinic, Independent Public Health Care Centre in Wrocław, Wrocław, Poland. + + + + Cicirko + Leszek + L + + Department of Physical Education and Sport, Faculty of Physical Education and Health in Biała Podlaska, Józef Piłsudski University of Physical Education in Warsaw, Warsaw, Poland. + + + + Konefał + Marek + M + + Department of Human Motor Skills, Wrocław University of Health and Sport Sciences, Wrocław, Poland. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 07 + 04 + + + 2022 + 10 + 05 + + + 2022 + 12 + 9 + 13 + 34 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490259 + 10.1371/journal.pone.0276314 + PONE-D-22-18881 + + +
+ + + 36490266 + + 2022 + 12 + 09 + +
+ + 2473-9537 + + + 2022 + Dec + 09 + + + Blood advances + Blood Adv + + Marginal zone B cells are responsible for the production of alloantibodies following platelet transfusion in mice. + bloodadvances.2022008411 + 10.1182/bloodadvances.2022008411 + + Alloimmunization against platelets remains a potentially serious adverse transfusion event. Alloantibodies produced by the recipient, mainly directed against HLA I donor antigens, can compromise the therapeutic efficacy of subsequent transfusions and may lead to refractoriness. Since the mechanism of anti-HLA alloantibody formation is poorly understood, the aim of this work was to identify the cells involved in the platelet immune response by focusing on the spleen, the main organ described to orchestrate this alloimmune response. In the spleen, transfused allogeneic platelets were located in the marginal zone and interacted with marginal zone B (MZB) cells, a specialized B cell population implicated in the capture and follicular delivery of blood-borne antigens. To study the involvement of MZB cells in alloantibody production, we used a murine model reproducing the MHC incompatibility between a donor (H2b) and a recipient (H2d) which occurs during platelet transfusion. Following weekly H2b platelet transfusions, recipient H2d mice produced anti-H2b IgG inducing a refractory state upon subsequent transfusions. Specific immunodepletion of MZB cells, or their displacement from the marginal zone to the B cell follicles by treatment with an S1P1 antagonist before each transfusion, prevented significant alloantibody formation. Under these conditions, transfused platelets were still circulating after 24 h, whereas they were rapidly removed from the circulation of alloimmunized mice. The identification of MZB cells as key players in the platelet alloimmune response opens up new perspectives to minimize platelet alloimmunization and avoid the associated refractory state in frequently transfused patients. + Copyright © 2022 American Society of Hematology. + + + + Couvidou + Adèle + A + 0000-0002-4141-6219 + + Université de Strasbourg, INSERM, EFS Grand-Est, BPPS UMR-S1255, FMTS, Strasbourg, France. + + + + Angénieux + Catherine + C + 0000-0002-0475-1165 + + EFS-Alsace, STRASBOURG, France. + + + + Ruch + Laurie + L + + Université de Strasbourg, INSERM, EFS Grand-Est, BPPS UMR-S1255, FMTS, Strasbourg cedex, France. + + + + Mangin + Pierre H + PH + 0000-0001-9522-6261 + + Université de Strasbourg, INSERM, EFS Grand Est, BPPS UMR-S1255, FMTS, Strasbourg, France. + + + + Gachet + Christian + C + 0000-0003-1303-4210 + + EFS, Inserm, Strasbourg, France. + + + + Maître + Blandine + B + + Université de Strasbourg, INSERM, EFS Grand-Est, BPPS UMR-S1255, FMTS, Strasbourg, France. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + Blood Adv + 101698425 + 2473-9529 + + IM +
+ + + + 2022 + 12 + 02 + + + 2022 + 06 + 24 + + + 2022 + 10 + 25 + + + 2022 + 12 + 9 + 13 + 34 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36490266 + 493604 + 10.1182/bloodadvances.2022008411 + + +
+ + + 36490281 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Impact of the COVID-19 pandemic on physical therapy practice in Saudi Arabia. + + e0278785 + + 10.1371/journal.pone.0278785 + + The new Coronavirus (COVID-19) pandemic has caused significant impact on the medical sector worldwide, including physical therapy (PT). The purpose of this study was to investigate the impact of the COVID-19 pandemic on the PT services, and the associated psychological distress endured by PT practitioners in Saudi Arabia. + A cross-sectional study was conducted to survey on-duty PT practitioners using a web-based questionnaire. Licensed PT practitioners working in Saudi Arabia (n = 265) participated and completed all the survey questions. The questionnaire comprised 30 questions covering the sociodemographic data and the outcome measures, which included the impact of the pandemic on the PT practice, use of telerehabilitation, administrative response during the pandemic, and PT practitioners' anxiety measured by the General Anxiety Disorder-7 scale. + During the lockdown, disruptive impact on the PT practice was reported by most of the participants (80%). The majority of PT clinics/departments were either partially (43.8%) or completely (31.3%) shutdown, and therapists treated patients less than usual. Around 30% of participants reported using a telerehabilitation approach during the pandemic to communicate with patients, and about 33% received online courses and webinars to adapt the PT practice in response to the pandemic. About 21% of participants endured moderate to severe levels of anxiety, which was more pronounced among females. + The COVID-19 pandemic significantly impacted the PT services in Saudi Arabia. Consequently, the number of patients treated was reduced, and therapists suffered notable psychological stress. Furthermore, although implemented, adaptive administrative measures were inadequate. Physical therapy practitioners and administrative authorities are encouraged to prioritize training and implementation of telerehabilitation as a likely prospective approach of PT practice. + Copyright: © 2022 Elsayed et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Elsayed + Walaa + W + https://orcid.org/0000-0001-5586-498X + + Department of Physical Therapy, College of Applied Medical Sciences, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia. + + + + Albagmi + Faisal + F + + Department of Physical Therapy, College of Applied Medical Sciences, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia. + + + + Hussain + Mehwish + M + + Department of Public Health, College of Public Health, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia. + + + + Alghamdi + Mohammed + M + + Department of Physical Therapy, College of Applied Medical Sciences, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia. + + + + Farrag + Ahmed + A + + Basic Science Department, Faculty of Physical Therapy, Cairo University, Cairo, Egypt. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2021 + 09 + 05 + + + 2022 + 11 + 11 + + + 2022 + 12 + 9 + 13 + 42 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490281 + 10.1371/journal.pone.0278785 + PONE-D-21-28813 + + +
+ + + 36490270 + + 2022 + 12 + 09 + +
+ + 1099-1166 + + 38 + 1 + + 2023 + Jan + + + International journal of geriatric psychiatry + Int J Geriatr Psychiatry + + What are the factors associated with people with advanced dementia refusing assistance with personal care? + + e5857 + + 10.1002/gps.5857 + + People with dementia sometimes refuse assistance with personal care activities such as washing or dressing. We aimed to investigate the factors associated with refusals of care in advanced dementia. + A cross-sectional study using informant-based measures. Participants were people with advanced dementia and their caregivers (family carers or care-home staff) (n = 260, 130 dyads) in the UK. Mixed effects linear models were used to examine the effects of neuropsychiatric behaviours, ability with activities of daily living, professional input, co-morbidities, psychotropic medications, environment modifications, and caregiver factors including type and training status on refusals of care. The Refusal of Care Informant Scale was used, range 1-13; higher scores indicate more refusal behaviours. + Higher independence in activities of daily living was associated with less refusal behaviours (coefficient = -0.11, p < 0.001 [95% confidence interval -0.15, -0.07]). Higher agitation was associated with more refusal behaviours (0.11, p < 0.001 [0.06, 0.15]). No other statistically significant differences were found. There was no demonstrable evidence of differences in number of refusals of care between family and care-home caregivers or between dementia-trained or -untrained caregivers. + Results suggest refusals of care have similar prevalence regardless of caregiver type (family or care home) or dementia training status, indicating that current dementia training has no impact on refusals of care or may not be implemented as intended. Improving independence in activities of daily living and reducing agitations may help prevent refusals of care. To establish causality, future research should consider embedding these factors into interventions targeting refusal of care. + © 2022 The Authors. International Journal of Geriatric Psychiatry published by John Wiley & Sons Ltd. + + + + Backhouse + Tamara + T + https://orcid.org/0000-0001-8194-4174 + + School of Health Sciences, University of East Anglia, Norwich, Norfolk, UK. + + + + Killett + Anne + A + + School of Health Sciences, University of East Anglia, Norwich, Norfolk, UK. + + + + Mioshi + Eneida + E + + School of Health Sciences, University of East Anglia, Norwich, Norfolk, UK. + + + + Khondoker + Mizanur + M + + Norwich Medical School, University of East Anglia, Norwich, Norfolk, UK. + + + + eng + + + National Institute for Health and Care Research Applied Research Collaboration East of England (ARC EoE) + + + + University of East Anglia + + + + AS-JF-17-002 + ALZS_ + Alzheimer's Society + United Kingdom + + + + Journal Article + +
+ + England + Int J Geriatr Psychiatry + 8710629 + 0885-6230 + + IM + + care home + dementia + family carer + refusals of care + resistance-to-care + +
+ + + + 2022 + 07 + 31 + + + 2022 + 11 + 21 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 9 + 13 + 34 + + + ppublish + + 36490270 + 10.1002/gps.5857 + + + REFERENCES + + World Health Organisation. Global Status Report on the Public Health Response to Dementia. 2021:137. Accessed November 28, 2022. https://www.who.int/publications/i/item/9789240033245 + + + Wittenberg R, Hu B, Barraza-Araiza B, Amritpal R. Projections of Older People with Dementia and Costs of Dementia Care in the UK 2019-2040. CPEC Working Paper 5, Care Policy and Evaluation Centre, London School of Economics and Political Science. 2019. + + + Reisberg B, Ferris SH, de Leon MJ, Crook T. The Global Deterioration Scale for assessment of primary degenerative dementia. Am J Psychiatr. 1982;139(9):1136-1139. + + + Giebel CM, Sutcliffe C, Challis D. Activities of daily living and quality of life across different stages of dementia: a UK study. Aging Ment Health. 2015;19(1):63-71. https://doi.org/10.1080/13607863.2014.915920 + + + O'Brien R, Beeke S, Pilnick A, Goldberg SE, Harwood RH. When people living with dementia say ‘no’: negotiating refusal in the acute hospital setting. Soc Sci Med. 2020;263:113188. https://doi.org/10.1016/j.socscimed.2020.113188 + + + Fauth EB, Femia EE, Zarit SH. Resistiveness to care during assistance with activities of daily living in non-institutionalized persons with dementia: associations with informal caregivers’ stress and well-being. Aging Ment Health. 2016;20(9):888-898. https://doi.org/10.1080/13607863.2015.1049114 + + + Backhouse T, Khondoker M, Killett A, Mioshi E. Most common refusals of personal care in advanced dementia: psychometric properties of the RoCIS. Gerontologist. 2022. + + + Kang B, Pan W, Karel MJ, McConnell ES. Rejection of care and aggression among older veterans with dementia: the influence of background factors and interpersonal triggers. J Am Med Dir Assoc. 2021;2(7):1435-1441. https://doi.org/10.1016/j.jamda.2021.03.032 + + + Featherstone K, Northcott A, Bridges J. Routines of resistance: an ethnography of the care of people living with dementia in acute hospital wards and its consequences. Int J Nurs Stud. 2019;96:53-60. https://doi.org/10.1016/j.ijnurstu.2018.12.009 + + + Rathnayake S, Jones C, Calleja P, Moyle M. Family carers' perspectives of managing activities of daily living and use of health applications in dementia care: a qualitative study. J Clin Nurs. 2019;28(23-24):4460-4470. https://doi.org/10.1111/jocn.15030 + + + Mortensen AH, Stojiljkovic M, Lillekroken D. Strategies to manage cognitive dissonance when experiencing resistiveness to care in people living with dementia: a qualitative study. J Adv Nurs. 2021;00:1-12. + + + Regier NG, Choi S, Gitlin LN. Rejection of care in persons with dementia. Innov Aging. 2019;3(suppl 1):S183. https://doi.org/10.1093/geroni/igz038.653 + + + Backhouse T. Understanding and reducing refusals of personal care in dementia. Nurs Resid Care. 2021;23:3-8. https://doi.org/10.12968/nrec.2021.23.3.8 + + + Backhouse T, Dudzinski E, Killett A, Mioshi E. Strategies and interventions to reduce or manage refusals in personal care in dementia: a systematic review. Int J Nurs Stud. 2020;109:103640. https://doi.org/10.1016/j.ijnurstu.2020.103640 + + + Belzil G, Vézina J. Impact of caregivers’ behaviors on resistiveness to care and collaboration in persons with dementia in the context of hygienic care: an interactional perspective. Int Psychogeriatr. 2015;27(11):1861-1873. https://doi.org/10.1017/s104161021500099x + + + Kang B, Karel MJ, Corazzini KN, McConnell ES. A mixed methods study on the manifestations of behavioural symptoms of dementia among veterans with and without posttraumatic stress disorder. J Adv Nurs. 2021;77(7):3176-3188. https://doi.org/10.1111/jan.14864 + + + Galindo-Garre F, Volicer L, van der Steen JT. Factors related to rejection of care and behaviors directed towards others: a longitudinal study in nursing home residents with dementia. Dement Geriatr Cogn Dis Extra. 2015;5(1):123-134. https://doi.org/10.1159/000369158 + + + Ishii S, Streim JE, Saliba D. Potentially reversible resident factors associated with rejection of care behaviors. J Am Geriatr Soc. 2010;58(9):1693-1700. https://doi.org/10.1111/j.1532-5415.2010.03020.x + + + Kable A, Guest M, McLeod M. Resistance to care: contributing factors and associated behaviours in healthcare facilities. J Adv Nurs. 2013;69(8):1747-1760. https://doi.org/10.1111/jan.12035 + + + Mioshi E, Hsieh S, Savage S, Hornberger M, Hodges JR. Clinical staging and disease progression in frontotemporal dementia. Neurology. 2010;74(20):1591-1597. https://doi.org/10.1212/wnl.0b013e3181e04070 + + + Care Quality Commission. The independent regulator of health and social care in England. Find a care home. Accessed April 04, 2022. https://www.cqc.org.uk/what-we-do/services-we-regulate/find-care-home + + + Mental Capacity Act, c.9. HMSO; 2005. + + + Faul F, Erdfelder E, Lang A.-G, Buchner A. A flexible statistical power analysis program for the social, behavioural, and biomedical sciences. Behav Res Methods. 2007;39(2):175-191. https://doi.org/10.3758/bf03193146 + + + Cummings J, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J. The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology. 1994;44(12):2308-2314. https://doi.org/10.1212/wnl.44.12.2308 + + + Cummings JL. The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. Neurology. 1997;48(Issue 5, supplement 6):S10-S16. https://doi.org/10.1212/wnl.48.5_suppl_6.10s + + + Cohen-Mansfield J. Agitated behaviors in the elderly II. Preliminary results in the cognitively deteriorated. 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+ + + 36490282 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Differential transcriptomic changes in the central nervous system and urinary bladders of mice infected with a coronavirus. + + e0278918 + + 10.1371/journal.pone.0278918 + + Multiple sclerosis (MS) often leads to the development of neurogenic lower urinary tract symptoms (LUTS). We previously characterized neurogenic bladder dysfunction in a mouse model of MS induced by a coronavirus, mouse hepatitis virus (MHV). The aim of the study was to identify genes and pathways linking neuroinflammation in the central nervous system with urinary bladder (UB) dysfunction to enhance our understanding of the mechanisms underlying LUTS in demyelinating diseases. Adult C57BL/6 male mice (N = 12) received either an intracranial injection of MHV (coronavirus-induced encephalomyelitis, CIE group), or sterile saline (control group). Spinal cord (SC) and urinary bladders (UB) were collected from CIE mice at 1 wk and 4 wks, followed by RNA isolation and NanoString nCounter Neuroinflammation assay. Transcriptome analysis of SC identified a significantly changed expression of >150 genes in CIE mice known to regulate astrocyte, microglia and oligodendrocyte functions, neuroinflammation and immune responses. Two genes were significantly upregulated (Ttr and Ms4a4a), and two were downregulated (Asb2 and Myct1) only in the UB of CIE mice. Siglec1 and Zbp1 were the only genes significantly upregulated in both tissues, suggesting a common transcriptomic link between neuroinflammation in the CNS and neurogenic changes in the UB of CIE mice. + Copyright: © 2022 Clarkson et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Clarkson + Taylor C + TC + + Division of Urology, Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America. + + + + Iguchi + Nao + N + + Division of Urology, Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America. + + + + Xie + Alison Xiaoqiao + AX + https://orcid.org/0000-0003-4395-8510 + + Division of Urology, Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America. + + + + Malykhina + Anna P + AP + https://orcid.org/0000-0002-9271-3096 + + Division of Urology, Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 09 + 21 + + + 2022 + 11 + 28 + + + 2022 + 12 + 9 + 13 + 42 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490282 + 10.1371/journal.pone.0278918 + PONE-D-22-25361 + + +
+ + + 36490272 + + 2022 + 12 + 09 + +
+ + 1099-1166 + + 38 + 1 + + 2023 + Jan + + + International journal of geriatric psychiatry + Int J Geriatr Psychiatry + + Are neuropsychiatric symptoms a marker of small vessel disease progression in older adults? Evidence from the Lothian Birth Cohort 1936. + + e5855 + + 10.1002/gps.5855 + + Neuropsychiatric symptoms could form part of an early cerebral small vessel disease prodrome that is detectable before stroke or dementia onset. We aimed to identify whether apathy, depression, anxiety, and subjective memory complaints associate with longitudinal white matter hyperintensity (WMH) progression. + Community-dwelling older adults from the observational Lothian Birth Cohort 1936 attended three visits at mean ages 73, 76, and 79 years, repeating MRI, Mini-Mental State Examination, neuropsychiatric (Dimensional Apathy Scale, Hospital Anxiety and Depression Scale), and subjective memory symptoms. We ran regression and mixed-effects models for symptoms and normalised WMH volumes (cube root of WMH:ICV × 10). + At age 73, 76, and 79, m = 672, n = 476, and n = 382 participants attended MRI respectively. Worse apathy at age 79 was associated with WMH volume increase (β = 0.27, p = 0.04) in the preceding 6 years. A 1SD increase in apathy score at age 79 associated with a 0.17 increase in WMH (β = 0.17 normalised WMH percent ICV, p = 0.009). In apathy subscales, executive (β = 0.13, p = 0.05) and emotional (β = 0.13, p = 0.04) scores associated with increasing WMH more than initiation scores (β = 0.11, p = 0.08). Increasing WMH also associated with age (β = 0.40, p = 0.002) but not higher depression (β = -0.01, p = 0.78), anxiety (β = 0.05, p = 0.13) scores, or subjective memory complaints (β = 1.12, p = 0.75). + Apathy independently associates with preceding longitudinal WMH progression, while depression, anxiety, and subjective memory complaints do not. Patients with apathy should be considered for enrolment to small vessel disease trials. + © 2022 The Authors. International Journal of Geriatric Psychiatry published by John Wiley & Sons Ltd. + + + + Clancy + Una + U + https://orcid.org/0000-0002-8062-7537 + + Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK. + + + UK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK. + + + + Radakovic + Ratko + R + + Department of Clinical Psychology and Psychological Therapies, University of East Anglia, Norwich, UK. + + + Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK. + + + Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK. + + + Euan MacDonald Centre for MND Research, University of Edinburgh, Edinburgh, UK. + + + + Doubal + Fergus + F + + Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK. + + + UK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK. + + + + Hernández + Maria Del C Valdés + MDCV + + Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK. + + + UK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK. + + + Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK. + + + Scottish Imaging Network, a Platform for Scientific Excellence (SINAPSE) Collaboration, Edinburgh, UK. + + + + Maniega + Susana Muñoz + SM + + Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK. + + + UK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK. + + + Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK. + + + Scottish Imaging Network, a Platform for Scientific Excellence (SINAPSE) Collaboration, Edinburgh, UK. + + + + Taylor + Adele M + AM + + Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK. + + + + Corley + Janie + J + + Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK. + + + + Chappell + Francesca M + FM + + Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK. + + + UK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK. + + + + Russ + Tom C + TC + + Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK. + + + Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK. + + + Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK. + + + + Cox + Simon R + SR + + Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK. + + + Scottish Imaging Network, a Platform for Scientific Excellence (SINAPSE) Collaboration, Edinburgh, UK. + + + + Bastin + Mark E + ME + + Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK. + + + UK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK. + + + Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK. + + + Scottish Imaging Network, a Platform for Scientific Excellence (SINAPSE) Collaboration, Edinburgh, UK. + + + + Deary + Ian J + IJ + + Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK. + + + Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK. + + + + Wardlaw + Joanna M + JM + + Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK. + + + UK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK. + + + Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK. + + + Scottish Imaging Network, a Platform for Scientific Excellence (SINAPSE) Collaboration, Edinburgh, UK. + + + + eng + + + Scottish Funding Council + + + + Alzheimer Scotland + + + + Mrs Gladys Row Fogo Charitable Trust + + + + Stroke Association + + + + Fondation Leducq + + + + UK Dementia Research Institute + + + + NHS Health Scotland + + + + Research Into Ageing + + + + NH + NIH HHS + United States + + + Age UK + + + + CSO_ + Chief Scientist Office + United Kingdom + + + BHF_ + British Heart Foundation + United Kingdom + + + NH + NIH HHS + United States + + + BB_ + Biotechnology and Biological Sciences Research Council + United Kingdom + + + MRC_ + Medical Research Council + United Kingdom + + + + Journal Article + +
+ + England + Int J Geriatr Psychiatry + 8710629 + 0885-6230 + + IM + + ageing + apathy + cerebral small vessel disease + cognition + longitudinal studies + white matter hyperintensities + +
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Fitting linear mixed-effects models using lme4. J Stat Softw. 2015;67(1):1-48. https://doi.org/10.18637/jss.v067.i01 + + + Baykara E , Gesierich B , Adam R , et al. A novel imaging marker for small vessel disease based on skeletonization of white matter tracts and diffusion histograms. Ann Neurol. 2016;80(4):581-592. https://doi.org/10.1002/ana.24758 + + + Deary IJ , Ritchie SJ , Muñoz Maniega S , et al. Brain peak width of skeletonized mean diffusivity (PSMD) and cognitive function in later life. Front Psychiatry. 2019;10:524. https://doi.org/10.3389/fpsyt.2019.00524 + + + Le Heron C , Manohar S , Plant O , et al. Dysfunctional effort-based decision-making underlies apathy in genetic cerebral small vessel disease. Brain J Neurol. 2018;141(11):3193-3210. https://doi.org/10.1093/brain/awy257 + + + Reyes S , Viswanathan A , Godin O , et al. Apathy: a major symptom in CADASIL. Neurology. 2009;72(10):905-910. https://doi.org/10.1212/01.wnl.0000344166.03470.f8 + + + +
+ + + 36490275 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Malnutrition among the aged population in Africa: A systematic review, meta-analysis, and meta-regression of studies over the past 20 years. + + e0278904 + + 10.1371/journal.pone.0278904 + + Nowadays, malnutrition among the advanced age (60 years and older) population is becoming a public health problem worldwide, especially in low-income countries including Africa. Hence, the prevalence in Africa is still not known. So, this review aimed to assess the pooled prevalence of under-nutrition among the advanced age population in Africa. + A study search was carried out using databases (such as African Journals Online, Web of Science, Global Index Medicus, Embess, and PubMed) and gray literature following PRISMA guidelines from April 20, 2022, to May 30, 2022, with no restriction on date of publication. We used a standardized extraction format to compile eligible studies as per the inclusion criteria. Then, systematic review and meta-analysis were employed using a random effect model to obtain the pooled prevalence of malnutrition among aged population living in Africa. The counter-funnel plot and at the 5% significance level, Egger's test and Begg's test were used to check for publication bias. Furthermore, a meta-regression analysis was carried out to identify the relationship between the outcome of interest and different predictors. + A total of 731 studies were identified and 28 met the inclusion criteria, which were conducted in 17 African countries. The pooled prevalence of under-nutrition in Africa was 17% (95%CI; 13.5-20.6). The prevalence of malnutrition among the elderly varied significantly across countries, ranging from 1.8% (95% CI; 0.96-2.63) in South Africa to 39.47% (95% CI; 31.70-47.24) in Kenya. According to meta-regression analysis, the likelihood of a malnutrition problem would be reduced by a factor of 9.84 (β = -9.84, 95 percent CI; _-14.97, -4.70, P = 0.00) in upper-middle income countries. In addition, based on the publication year, malnutrition has decreased by a factor of 0.75 (β = -0.75, 95%CI:-1.49, -0.01, P = 0.04) from 1998 to 2021. + There is a high prevalence of malnutrition among the aged population. So, this underserved population should be targeted for intervention programs and/or integrated into maternal and child nutrition programs. + Copyright: © 2022 Ewunie et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Ewunie + Temesgen Muche + TM + https://orcid.org/0000-0002-2922-1881 + + Department of Human Nutrition, College of Medicine and Health Science, Dilla University, Dilla, Ethiopia. + + + + Hareru + Habtamu Endashaw + HE + + School of Public Health, College of Medicine and Health Science, Dilla University, Dilla, Ethiopia. + + + + Dejene + Tadesse Mamo + TM + + Department of Public Health, Asrat Woldeyes Health Science Campus, Debre Birhan University, Debre Birhan, Ethiopia. + + + + Abate + Semagn Mekonen + SM + https://orcid.org/0000-0001-5661-8537 + + Department of Anesthesiology, College of Medicine and Health Science, Dilla University, Dilla, Ethiopia. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 06 + 30 + + + 2022 + 11 + 27 + + + 2022 + 12 + 9 + 13 + 34 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490275 + 10.1371/journal.pone.0278904 + PONE-D-22-18456 + + +
+ + + 36490278 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + The corneo-scleral junction assessed with optical coherence tomography. + + e0278884 + + 10.1371/journal.pone.0278884 + + To evaluate corneo-scleral junction (CSJ) using anterior segment optical coherence tomography (AS-OCT) and describe the pattern of cornea and sclera interfusion based on tissue reflectivity. + This prospective observational study enrolled candidates for vision correction. Eyes with previous ocular surgery or irregular corneas were excluded. Temporal and nasal CSJ width and reflectivity patterns were assessed with AS-OCT horizontal scans. Correlations between manual and automated variables and multivariate linear regression analyses with age and spherical equivalent were performed. + 101 right eyes were analysed. Temporal CSJ was wider (median 1.62; 1.13 to 2.22 mm) compared to the nasal side (median 1.18; 0.73 to 1.80 mm) (p<.0001). The temporal CSJ width showed negative correlation with ipsilateral anterior chamber angle measurements and positive correlation with horizontal visible iris diameter (HVID). These relationships were not statistically significant for the nasal CSJ width. No significant correlations with age or refractive error were observed at both sides. The pattern of temporal CSJ reflectivity was mostly V- or U-shaped. The eyes with V-shaped temporal CSJ had significantly larger HVID than the eyes with irregular temporal CSJ. The nasal CSJ presented irregular reflectivity in 47% of cases. + The temporal CSJ was wider and had regular (V or U-shaped) reflectivity patterns, while nasal CSJ was narrower and more irregular. The CSJ width was independent of age and refractive error and could not be predicted from other parameters. The HVID measurement accuracy may benefit from CSJ analysis based on AS-OCT. + Copyright: © 2022 Muzyka-Woźniak et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Muzyka-Woźniak + Maria + M + https://orcid.org/0000-0002-4666-2400 + + Ophthalmology Clinical Centre SPEKTRUM, Wrocław, Poland. + + + + Oleszko + Adam + A + + Ophthalmology Clinical Centre SPEKTRUM, Wrocław, Poland. + + + + Stróżecki + Łukasz + Ł + + Department of Anaesthesiology and Intensive Therapy, Wroclaw Medical University, Wrocław, Poland. + + + + Woźniak + Sławomir + S + + Department of Human Morphology and Embriology, Department of Anatomy, Wroclaw Medical University, Wrocław, Poland. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 03 + 05 + + + 2022 + 11 + 26 + + + 2022 + 12 + 9 + 13 + 35 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490278 + 10.1371/journal.pone.0278884 + PONE-D-22-06612 + + +
+ + + 36490274 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Association between dietary knowledge and overweight and obesity in Chinese children and adolescents: Evidence from the China Health and Nutrition Survey in 2004-2015. + + e0278945 + + 10.1371/journal.pone.0278945 + + To assess whether dietary knowledge of Chinese children and adolescents and their mothers was associated with childhood and adolescent overweight and obesity. + This cross-sectional study obtained data from the China Health and Nutrition Survey (CHNS) between 2004 and 2015. Dietary knowledge of children and adolescents and their mothers was assessed by asking questions and statements on diets, and clustered by K-means clustering. Body mass index (BMI) and waist circumference (WC) were used to evaluate overweight and obesity among children and adolescents. The association of dietary knowledge with childhood and adolescent overweight and obesity was evaluated by multivariate regression analysis, with odds ratios (ORs) and 95% confidence intervals (CIs) calculated. + A total of 2,338 children and adolescents were included. Children and adolescents with low dietary knowledge were demonstrated to have significantly higher risks of BMI-defined overweight or obesity (OR = 1.66, 95%CI = 1.21-2.28, P = 0.002), and WC-defined obesity (OR = 1.52, 95%CI = 1.12-2.06, P = 0.007) than those with high dietary knowledge. Compared with high dietary knowledge in mothers, low dietary knowledge was associated with significantly elevated risks of BMI-defined overweight or obesity (OR = 1.48, 95%CI = 1.08-2.02, P = 0.014), and WC-defined obesity (OR = 1.59, 95%CI = 1.18-2.16, P = 0.003). Furthermore, significantly increased odds of BMI-defined overweight or obesity and WC-defined non-obesity in children and adolescents were related to low dietary knowledge versus high dietary knowledge of children and adolescents (OR = 1.72, 95%CI = 1.08-2.74, P = 0.023), while there was no association of BMI-defined non-overweight and non-obesity and WC-defined obesity with dietary knowledge among children and adolescents (OR = 1.35, 95%CI = 0.89-2.04, P = 0.161). Additionally, no association was found between dietary knowledge of mothers and BMI-defined overweight or obesity and WC-defined non-obesity among children and adolescents (OR = 1.39, 95%CI = 0.89-2.17, P = 0.155), while low dietary knowledge of mothers was associated with increased odds of BMI-defined non-overweight and non-obesity and WC-defined obesity in children and adolescents (OR = 1.58, 95%CI = 1.03-2.43, P = 0.036). + Dietary knowledge of children and adolescents and their mothers was associated with childhood and adolescent overweight and obesity. Dietary knowledge of children and adolescents negatively related to the risk of BMI-defined overweight or obesity, and dietary knowledge of mothers to odds of WC-defined obesity. + Copyright: © 2022 Xu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Xu + Zhen + Z + + Department of Child healthcare, Kunming Children's Hospital, Kunming, Yunnan, China. + + + + Zhao + Yibin + Y + + Department of Child Rehabilitation, Kunming Children's Hospital, Kunming, Yunnan, China. + + + + Sun + Jingjing + J + + Department of Child healthcare, Kunming Children's Hospital, Kunming, Yunnan, China. + + + + Luo + Lisi + L + + Department of Child healthcare, Kunming Children's Hospital, Kunming, Yunnan, China. + + + + Ling + Yu + Y + https://orcid.org/0000-0002-1473-9311 + + Department of Child healthcare, Kunming Children's Hospital, Kunming, Yunnan, China. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 05 + 20 + + + 2022 + 11 + 24 + + + 2022 + 12 + 9 + 13 + 34 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490274 + 10.1371/journal.pone.0278945 + PONE-D-22-14519 + + +
+ + + 36490279 + + 2022 + 12 + 09 + +
+ + 1365-2923 + + + 2022 + Dec + 09 + + + Medical education + Med Educ + + Internal Medicine trainee perspectives on back-up call systems and relationships to burnout. + 10.1111/medu.15003 + + As burnout within medicine escalates, residency programs should strive to understand how training structures may contribute. Back-up call systems that address gaps in overnight resident call coverage are one possible contributing structure. However, the intersection between back-up call policies and burnout remains unclear. The authors explored residents' decision-making process when deciding whether or not to activate a back-up resident for call coverage, perspectives surrounding the legitimacy of call activations, and the impact of back-up call systems on education and experienced burnout. + Internal medicine residents at the University of Toronto were recruited through email. Eighteen semi-structured one-on-one interviews were conducted with residents from September 2019 to February 2020. Interviews explored participants' experiences and perceptions with back-up call and call activations. A constructivist grounded theory approach was used to develop a conceptual understanding of the back-up system as it relates to residents' decisions underlying activations, downstream impacts, and relationships to burnout. + Residents described a complex thought process when deciding whether to activate back-up. Decisions were coloured by inner conflicts including sense of collegiality, need to maintain an image, and time of year balanced against self-reported burnout. Residents described how back-up calls can lead to burnout, usually in the form of exhaustion, lowering their threshold to trigger future back-up activations. Impacts included anxiety of not knowing whether an activation would occur, decreased educational productivity and the "domino effect" of increased workload for colleagues. + Residents weigh inner tensions when deciding to activate back-up. Their collective experience suggests that burnout is both a trigger and consequence of back-up calls, creating a cyclical relationship. Escalating rates of call activations may signal that burnout amongst residents is high, warranting educational leads to assess for resident wellness and to critically evaluate the structure of such systems with respect to unintended consequences. + This article is protected by copyright. All rights reserved. + + + + Sheikh + Natasha + N + https://orcid.org/0000-0001-9001-4278 + + Internal Medicine Residency Program, Department of Medicine, University of Toronto, Toronto, Ontario, Canada. + + + + Ng + Stella L + SL + https://orcid.org/0000-0003-1433-6851 + + Centre for Interprofessional Education, and an Associate Professor, University of Toronto, Toronto, Ontario, Canada. + + + + Flett + Heather + H + + Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. + + + + Shah + Rupal + R + + Division of General Internal Medicine, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada and Faculty Member of the HoPingKong Centre for Excellence in Education and Practice, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + England + Med Educ + 7605655 + 0308-0110 + + IM +
+ + + + 2022 + 10 + 05 + + + 2022 + 05 + 31 + + + 2022 + 12 + 06 + + + 2022 + 12 + 9 + 13 + 35 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36490279 + 10.1111/medu.15003 + + +
+ + + 36490273 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Cognitive adverse effects of epilepsy and its predictors attending outpatient department of South Gondar zone hospitals, Amhara Region, Ethiopia 2020 /2021. + + e0278908 + + 10.1371/journal.pone.0278908 + + Epilepsy is the most common neurologic disorder which is further complicated by neurobehavioral co-morbidities, cognitive impairment, psychiatric disorders, and social problems. However, assessments of cognitive status of epileptic patients are far too low during clinical visits. This calls for early neuropsychological assessment soon after the diagnosis of epilepsy for a better treatment plan and outcome for epileptic patients. + This study aimed to assess the cognitive adverse effects of epilepsy and its predictors attending outpatient departments of South Gondar Zone hospitals Amhara region Ethiopia 2020/2021. + A multi-center institutional-based cross-sectional study was conducted. A total of 509 respondents were included with a response rate of 93.9%. Previously adapted pretested structured questionnaire was used containing, socio-demographic, clinical, and seizure related factors. Mini-Mental State Examination (MMSE) was used to measure cognitive impairment. A systematic random sampling technique was applied. Data were entered into Epi data version 4.4.2 then exported to SPSS version 24 for analysis. Descriptive statistics, bivariable and multivariable binary logistic regressions with odds ratios and 95% confidence interval were employed. The level of significance of association was determined at a p-value < 0.05. + Prevalence of cognitive impairment in this study was 69.2% (95%CI; 65.4, 73.1). Rural residents (AOR = 4.16,95%CI, 1.99,8.67), respondents who couldn't read and write (AOR = 2.62, 95%CI; 1.24, 5.5,) longer duration of seizure disorder (AOR = 4.59,95%CI; 2.01,10.52), taking combined Phenobarbital and Phenytoin (AOR = 4.69,95%CI; 1.88,11.69), having history of head injury (AOR = 3.29,95%CI;1.30,8.32), having depression (AOR = 4.76,95%CI;2.83,7.98), and anxiety (AOR = 3.11,95%CI; 1.58,6.12) were significantly associated with cognitive impairment. + Prevalence of cognitive impairment in this study was high. Regular neuropsychiatric assessment of patients with epilepsy should be encouraged especially for those participants with longer durations of illness, who are rural residents, who take combined Phenobarbital and Phenytoin, participants who had a history of head injury, depression, and anxiety. + Copyright: © 2022 Asnakew et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Asnakew + Sintayehu + S + https://orcid.org/0000-0002-1241-4468 + + Department of Psychiatry, School of Medicine, College of Health Science, Debre Tabor University, Debre Tabor, Ethiopia. + + + + Legas + Getasew + G + + Department of Psychiatry, School of Medicine, College of Health Science, Debre Tabor University, Debre Tabor, Ethiopia. + + + + Belete + Amsalu + A + + Department of Psychiatry, School of Medicine, College of Health Science, Debre Tabor University, Debre Tabor, Ethiopia. + + + + Admasu + Fitalew Tadele + FT + + Department of Biomedical Sciences, College of Health Science, Debre Tabor University, Debre Tabor, Ethiopia. + + + + Yitbarek + Getachew Yideg + GY + + Department of Biomedical Sciences, College of Health Science, Debre Tabor University, Debre Tabor, Ethiopia. + + + + Aytenew + Tigabu Munye + TM + + Department of Nursing, College of Health Science Debre Tabor University, Debre Tabor, Ethiopia. + + + + Demise + Biruk + B + + Departments of Social and Population Health, College of Health Science, Debre Tabor University, Debre Tabor, Ethiopia. + + + + Alemu + Eshetie Molla + EM + + Departments of Social and Population Health, College of Health Science, Debre Tabor University, Debre Tabor, Ethiopia. + + + + Alemu + Muluken Adela + MA + + Departemnt of Pharmacy, College of Health Science, Debre Tabor University, Debre Tabor, Ethiopia. + + + + Bayih + Wubet Alebachew + WA + + Department of Pediatrics and Child Health and Neonatal Nursing, College of Health Science, Debre Tabor University, Debre Tabor, Ethiopia. + + + + Feleke + Dejen Getaneh + DG + + Department of Pediatrics and Child Health and Neonatal Nursing, College of Health Science, Debre Tabor University, Debre Tabor, Ethiopia. + + + + Chanie + Ermias Sisay + ES + + Department of Pediatrics and Child Health and Neonatal Nursing, College of Health Science, Debre Tabor University, Debre Tabor, Ethiopia. + + + + Birhane + Binyam Munye + BM + + Department of Pediatrics and Child Health and Neonatal Nursing, College of Health Science, Debre Tabor University, Debre Tabor, Ethiopia. + + + + Kefale + Demewoz + D + + Department of Pediatrics and Child Health and Neonatal Nursing, College of Health Science, Debre Tabor University, Debre Tabor, Ethiopia. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 04 + 28 + + + 2022 + 11 + 28 + + + 2022 + 12 + 9 + 13 + 34 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490273 + 10.1371/journal.pone.0278908 + PONE-D-22-12489 + + +
+ + + 36490285 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Leader extraversion and team performance: A moderated mediation model. + + e0278769 + + 10.1371/journal.pone.0278769 + + Extraversion is the best and most consistent predictor of important leadership outcomes. However, there has been little exploration and examination of the mechanisms underlying the effects of extraverted leadership on performance. Drawing on distal-proximal motivational theory and situational strength theory, the present study proposes and examines a moderated mediation model that explains how leader extraversion affects team performance and how situational characteristics strengthen or constrain this relationship. Respondents were recruited through management team training courses run by the eight Chinese companies. We conducted two rounds of electronic questionnaire collection. The first round of data was collected during the training session. Four weeks later, we collected the data through the training courses' WeChat groups. Data collected from 226 Chinese team leaders was analyzed using SPSS 26 and Mplus 7. We find that leader extraversion predicts team performance through a motivational mechanism operationalized as leader work engagement. We further find that goal clarity and process clarity play an important role in strengthening the positive effect of leader extraversion on leader work engagement as well as the motivational mechanism, providing an empirical explanation of how leader extraversion affects team performance through a motivational mechanism operationalized as leader work engagement. We also explore how two potential situational characteristics, operationalized as goal clarity and process clarity of leaders, affect the relationship between leader extraversion and leader work engagement as well as the motivational mechanism. Addionally, the findings suggest important practical implications for the organizations seeking to identify effective team leaders. + Copyright: © 2022 Zhang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Zhang + Jun + J + https://orcid.org/0000-0001-8384-2227 + + Faculty of Humanities and Social Sciences, Beijing Institute of Petrochemical Technology, Beijing, People's Republic of China. + + + + Yin + Kui + K + + Donlinks School of Economics and Management, University of Science and Technology Beijing, Beijing, People's Republic of China. + + + + Li + SiQi + S + + Faculty of Humanities and Social Sciences, Beijing Institute of Petrochemical Technology, Beijing, People's Republic of China. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 07 + 19 + + + 2022 + 11 + 22 + + + 2022 + 12 + 9 + 13 + 43 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490285 + 10.1371/journal.pone.0278769 + PONE-D-22-19951 + + +
+ + + 36490283 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Collateral positives of COVID-19 for culturally and linguistically diverse communities in Western Sydney, Australia. + + e0278923 + + 10.1371/journal.pone.0278923 + + To investigate whether culturally and linguistically diverse (CALD) communities in Western Sydney have experienced any positive effects during the COVID-19 pandemic, and if so, what these were. + A cross-sectional survey with ten language groups was conducted from 21st March to 9th July 2021 in Sydney, Australia. Participants were recruited through bilingual multicultural health staff and health care interpreter service staff and answered a question, 'In your life, have you experienced any positive effects from the COVID-19 pandemic?' Differences were explored by demographic variables. Free-text responses were thematically coded using the Content Analysis method. + 707 people completed the survey, aged 18 to >70, 49% males and 51% females. Only 161 (23%) of those surveyed reported any positive impacts. There were significant differences in the proportion of those who reported positives based on age (p = 0.004), gender (p = 0.013), language (p = 0.003), health literacy (p = 0.014), English language proficiency (p = 0.003), education (p = <0.001) and whether participants had children less than 18 years at home (p = 0.001). Content Analysis of open-ended responses showed that, of those that did report positives, the top themes were 'Family time' (44%), 'Improved self-care' (31%) and, 'Greater connection with others' (17%). + Few surveyed participants reported finding any positives stemming from the COVID-19 pandemic. This finding is in stark contrast to related research in Australia with participants whose native language is English in which many more people experienced positives. The needs of people from CALD backgrounds must inform future responses to community crises to facilitate an equitable effect of any collateral positives that may arise. + Copyright: © 2022 Cornell et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Cornell + Samuel + S + https://orcid.org/0000-0003-4944-7826 + + Sydney Health Literacy Lab, School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. + + + + Ayre + Julie + J + https://orcid.org/0000-0002-5279-5189 + + Sydney Health Literacy Lab, School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. + + + + Mac + Olivia + O + + Sydney Health Literacy Lab, School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. + + + + Kapoor + Raveena + R + + Sydney Health Literacy Lab, School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. + + + + Pickles + Kristen + K + https://orcid.org/0000-0002-1621-3217 + + Sydney Health Literacy Lab, School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. + + + + Batcup + Carys + C + + Sydney Health Literacy Lab, School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. + + + + Dolan + Hankiz + H + + Sydney Health Literacy Lab, School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. + + + + Bonner + Carissa + C + + Sydney Health Literacy Lab, School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. + + + + Cvejic + Erin + E + https://orcid.org/0000-0002-6043-6071 + + Sydney Health Literacy Lab, School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. + + + + Mouwad + Dana + D + + Western Sydney Local Health District, North Parramatta, New South Wales, Australia. + + + + Zacharia + Dipti + D + + Western Sydney Local Health District, North Parramatta, New South Wales, Australia. + + + + Tularic + Una + U + + Nepean Blue Mountains Local Health District, Kingswood, New South Wales, Australia. + + + + Santalucia + Yvonne + Y + + Southwestern Sydney Local Health District, Warwick Farm, New South Wales, Australia. + + + + Chen + Ting Ting + TT + + Western Sydney Local Health District, North Parramatta, New South Wales, Australia. + + + + Basic + Gordana + G + + Western Sydney Local Health District, North Parramatta, New South Wales, Australia. + + + + McCaffery + Kirsten + K + https://orcid.org/0000-0003-2696-5006 + + Sydney Health Literacy Lab, School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. + + + + Muscat + Danielle + D + + Sydney Health Literacy Lab, School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors declare that they have no competing interests. +
+ + + + 2022 + 08 + 01 + + + 2022 + 11 + 23 + + + 2022 + 12 + 9 + 13 + 42 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490283 + 10.1371/journal.pone.0278923 + PONE-D-22-21636 + + +
+ + + 36490280 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Hybrid fuzzy inference rules of descent method and wavelet function for volatility forecasting. + + e0278835 + + 10.1371/journal.pone.0278835 + + This research employs the gradient descent learning (FIR.DM) approach as a learning process in a nonlinear spectral model of maximum overlapping discrete wavelet transform (MODWT) to improve volatility prediction of daily stock market prices using Saudi Arabia's stock exchange (Tadawul) data. The MODWT comprises five mathematical functions and fuzzy inference rules. The inputs are the oil price (Loil) and repo rate (Repo) according to multiple regression correlation, and the Engle and Granger Causality test Engle RF, (1987). The logarithm of the stock market price (LSCS) in Tadawul reflects the output variable. The correlation matrix reveals that there is no collinearity between the input variables, and the causality test demonstrates that the input variables significantly influence the outcome variable. According to the multiple regression, there is a substantial negative influence between Loil and LSCS but a significant positive effect between Repo and output. For the 80% dataset under ME (0.000005), MAE (0.003214), and MAPE (0.064497), the MODWT-LA8 (ARIMA(1,1,0) with drift) for the LSCS variable performs better than other WT functions. In the novel hybrid model MODWT-FIR.DM, each function's approximation coefficient (LSCS) is applied with input variables (Loil and Repo). We evaluate the performance of the proposed model (MODWT-LA8-FIR.DM) using different statistical measures (ME, RMSE, MAE, MPE) and compare it to two established models: the original FIR.DM and other MODWT-FIR.DM functions for forecasting 20% of datasets. The outcomes show that the MODWT-LA8-FIR.DM performs better than the traditional models based on lower ME (3.167586), RMSE (3.167638), MAE (3.167586), and MPE (80.860849). The proposed hybrid model may be a potential stock market forecasting model. + Copyright: © 2022 Alenezy et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Alenezy + Abdullah H + AH + + Department of mathematics, College of Science, University of Ha'il, Hail, Kingdom of Saudi Arabia. + + + School of Mathematical Science, Universiti Sains Malaysia, Penang, Malaysia. + + + + Ismail + Mohd Tahir + MT + + School of Mathematical Science, Universiti Sains Malaysia, Penang, Malaysia. + + + + Jaber + Jamil J + JJ + + Department of Finance, School of Business, The University of Jordan, Aqaba, Jordan. + + + + Wadi + S Al + SA + + Department of Finance, School of Business, The University of Jordan, Aqaba, Jordan. + + + + Alkhawaldeh + Rami S + RS + https://orcid.org/0000-0002-2413-7074 + + Department of Computer Information Systems, The University of Jordan, Aqaba, Jordan. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 06 + 06 + + + 2022 + 11 + 23 + + + 2022 + 12 + 9 + 13 + 35 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490280 + 10.1371/journal.pone.0278835 + PONE-D-22-16360 + + +
+ + + 36490276 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Direct in situ protein tagging in Chlamydomonas reinhardtii utilizing TIM, a method for CRISPR/Cas9-based targeted insertional mutagenesis. + + e0278972 + + 10.1371/journal.pone.0278972 + + Chlamydomonas reinhardtii is an important model organism for the study of many cellular processes, and protein tagging is an increasingly indispensable tool for these studies. To circumvent the disadvantages of conventional approaches in creating a tagged cell line, which involve transforming either a wild-type or null-mutant cell line with an exogenous DNA construct that inserts randomly into the genome, we developed a strategy to tag the endogenous gene in situ. The strategy utilizes TIM, a CRISPR/Cas9-based method for targeted insertional mutagenesis in C. reinhardtii. We have tested the strategy on two genes: LF5/CDKL5, lack of which causes a long-flagella phenotype, and Cre09.g416350/NAP1L1, which has not been studied previously in C. reinhardtii. We successfully tagged the C-terminus of wild-type LF5 with the hemagglutinin (HA) tag with an efficiency of 7.4%. Sequencing confirmed that these strains are correctly edited. Western blotting confirmed the expression of HA-tagged LF5, and immunofluorescence microscopy showed that LF5-HA is localized normally. These strains have normal length flagella and appear wild type. We successfully tagged the N-terminus of Cre09.g416350 with mNeonGreen-3xFLAG with an efficiency of 9%. Sequencing showed that the tag region in these strains is as expected. Western blotting confirmed the expression of tagged protein of the expected size in these strains, which appeared to have normal cell size, growth rate, and swimming speed. This is the first time that C. reinhardtii endogenous genes have been edited in situ to express a wild-type tagged protein. This effective, efficient, and convenient TIM-tagging strategy promises to be a useful tool for the study of nuclear genes, including essential genes, in C. reinhardtii. + Copyright: © 2022 Hou et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Hou + Yuqing + Y + https://orcid.org/0000-0002-7038-675X + + Division of Cell Biology and Imaging, Department of Radiology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America. + + + + Cheng + Xi + X + + Division of Cell Biology and Imaging, Department of Radiology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America. + + + + Witman + George B + GB + https://orcid.org/0000-0002-9497-9218 + + Division of Cell Biology and Imaging, Department of Radiology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 07 + 18 + + + 2022 + 11 + 28 + + + 2022 + 12 + 9 + 13 + 34 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490276 + 10.1371/journal.pone.0278972 + PONE-D-22-20272 + + +
+ + + 36490277 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Development of a customized mask retainer for improving the fit performance of surgical masks. + + e0278889 + + 10.1371/journal.pone.0278889 + + This study introduces a customized mask retainer to improve the fit performance of surgical masks using various advanced digital techniques. The participant's 3D face scans with and without a surgical mask were taken by using a smartphone. The mask retainer was designed using the 3D face scan data based on the facial anthropometric landmarks. The fitting was inspected and adjusted using the masked face scan data. The retainer was fabricated using a 3D printer. The effectiveness of the retainer on the augmentation of the fit of the surgical mask was tested according to the Chinese Standard (GB 19083-2010). A questionnaire was used to assess the effect of wearing surgical masks with and without retainers and N95 respirators on subjective perception of discomfort. The effectiveness test of the retainer on the augmentation of the fit performance showed a better than 25-fold increase in the overall fit factor, meeting the fit requirement for KN95 respirators in China. The subjective perception of discomfort of wearing N95 was significantly greater than surgical mask with and without retainers. The fit factor results indicated that by using the retainer, the overall fit factors and that of each exercise significantly increased compared to that of the group with the surgical mask alone. And compared with N95, the surgical mask with the retainer significant improved comfort. The surgical mask with the retainer can provide an alternative of personal protective equipment for healthcare workers. + Copyright: © 2022 Pan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Pan + Yuanyuan + Y + + Department of Prosthodontics, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China. + + + + Xi + Qi + Q + + Xuanwu Stomatological Hospital, Nanjing, China. + + + + Meng + Jiali + J + + Digital Engineering Center of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China. + + + + Chen + Xi + X + + Digital Stomatology Center, the Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, China. + + + + Wu + Guofeng + G + https://orcid.org/0000-0002-6531-9472 + + Department of Prosthodontics, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China. + + + Digital Engineering Center of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 07 + 24 + + + 2022 + 11 + 27 + + + 2022 + 12 + 9 + 13 + 34 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490277 + 10.1371/journal.pone.0278889 + PONE-D-22-20668 + + +
+ + + 36490284 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Pre-service factors associated with sexual misconduct among male U.S. Marines. + + e0278640 + + 10.1371/journal.pone.0278640 + + Sexual assault is a prevalent and persistent problem in the military, yet few studies have examined predictors of sexual offenses. The study aim was to determine pre-service factors associated with sexual offense conviction among U.S. Marines. + This retrospective cohort study analyzed data from male active duty U.S. Marines (2003-2018). Pre-service factors were assessed using survey data from the Recruit Assessment Program, obtained prior to recruit training at the Marine Corps Recruit Depot, San Diego, California. These survey data were linked with sexual offense conviction data obtained from the Naval Criminal Investigative Service Consolidated Law Enforcement Operations Center. + Of the 146,307 participants, the majority were 18-19 years old (66.7%) and non-Hispanic, White (62.1%) with a high school education or less (76.8%); 107 received convictions for a sexual offense. In unadjusted analyses, race and ethnicity, parental education, type of primary caregiver, parental death, family economic status, childhood emotional trauma, childhood physical abuse, childhood sexual abuse, and unprotected sex were associated with a sexual offense conviction. In the final multivariable model, race and ethnicity (American Indian/Alaskan Native, odds ratio [OR]: 5.28, 95% confidence interval [CI]: 1.86-14.98; Hispanic, OR: 1.83, 95% CI: 1.06-3.18; multiracial/other, OR: 3.28, 95% CI: 1.56-6.89), education (≤ high school, OR: 2.65; 95% CI: 1.21-5.80), parental death (OR: 2.27; 95% CI: 1.16-4.45), unprotected sex (OR: 1.78; 95% CI: 1.03-3.05), and school suspension/expulsion (OR: 1.64; 95% CI: 1.02-2.65) were significant predictors of a subsequent sexual offense conviction. + Results underscore the importance of understanding factors associated with sexual offense and highlight the large discrepancy between self-reported estimates of sexual assault and sexual offense convictions. Findings may inform the development of effective strategies to reduce sexual misconduct, such as technology-facilitated programs that provide private, targeted education; supportive assistance; and prevention materials to individuals who may have elevated sexual misconduct risk. + Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. + + + + LeardMann + Cynthia A + CA + https://orcid.org/0000-0002-3683-6016 + + Leidos, San Diego, California, United States of America. + + + Deployment Health Research Department, Naval Health Research Center, San Diego, California, United States of America. + + + + Haile + Yohannes G + YG + + Leidos, San Diego, California, United States of America. + + + Deployment Health Research Department, Naval Health Research Center, San Diego, California, United States of America. + + + + McAnany + Jennifer + J + + Leidos, San Diego, California, United States of America. + + + Deployment Health Research Department, Naval Health Research Center, San Diego, California, United States of America. + + + + Stander + Valerie A + VA + + Deployment Health Research Department, Naval Health Research Center, San Diego, California, United States of America. + + + + Williams + Diane + D + + Warfighter Performance Research Department, Naval Health Research Center, San Diego, California, United States of America. + + + + Millegan + Jeffrey + J + + Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America. + + + + Carlton + Keyia N + KN + + Deployment Health Research Department, Naval Health Research Center, San Diego, California, United States of America. + + + + Recruit Assessment Program + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 07 + 15 + + + 2022 + 11 + 19 + + + 2022 + 12 + 9 + 13 + 42 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490284 + 10.1371/journal.pone.0278640 + PONE-D-22-20056 + + +
+ + + 36490286 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Assessment and spatial partitioning of ecosystem services importance in Giant Panda National Park: To provide targeted ecological protection. + + e0278877 + + 10.1371/journal.pone.0278877 + + Giant Panda National Park is crucial for China's ecological security strategic pattern known as "two screens and three belts." The importance assessment and classification of ecosystem services in giant panda national parks has an important guiding role in the protection of giant panda national park ecosystems. In this study, we examined four indicators of habitat quality: carbon storage, water conservation, and soil and water conservation. Combined with data analysis were used to evaluate and classify the importance of ecosystem services in the study area. The results showed that: (1) the overall habitat quality index in the study area was relatively high, and the index was generally greater than 0.5. The total carbon storage was 60.5 × 106 t, and the highest carbon storage in the region was 16.9533 t. The area with the highest water conservation reached 715.275 mm. The total soil conservation was 2555.7 × 107 t. (2) From the perspective of spatial characteristics, the habitat quality in the study area presented a spatial distribution pattern of high-low from west to east. The carbon storage presented a spatial distribution pattern of high-low from east to west. The soil conservation presented a spatial pattern of decreasing from west to east, and the water conservation increased from west to east. (3) We divided the research into four levels of importance: The area of general importance in the study site accounted for 1017.58 km2 and was distributed in the northwest of the study site. The moderately important areas were distributed in the east of the study site, with an area of 1142.40 km2. The highly important areas were distributed in the west of the study site, totaling 2647.84 km2. Extremely important areas were distributed in the middle, with an area of 1451.32 km2. (4) The grid cell scale of the study area was used as the dataset to determine the weighting. This makes the weighting more objective and ensures that the spatial distribution of areas with different degrees of importance will be more accurate. + Copyright: © 2022 Li, Zhu. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Li + Zhigang + Z + + School of Management Science, Chengdu University of Technology, Chengdu, China. + + + Protection Policy Research Center for Key Ecological Functional Areas in the Upper Reaches of the Yangtze River, China. + + + + Zhu + Jiaxing + J + https://orcid.org/0000-0001-6468-2555 + + College of Earth Sciences, Chengdu Univ. of Technology, Chengdu, PR China. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 08 + 03 + + + 2022 + 11 + 24 + + + 2022 + 12 + 9 + 13 + 43 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490286 + 10.1371/journal.pone.0278877 + PONE-D-22-21836 + + +
+ + + 36490287 + + 2022 + 12 + 09 + +
+ + 2473-9537 + + + 2022 + Dec + 09 + + + Blood advances + Blood Adv + + Separate roles of LMAN1 and MCFD2 in ER-to-Golgi trafficking of FV and FVIII. + bloodadvances.2022008788 + 10.1182/bloodadvances.2022008788 + + Mutations in LMAN1 and MCFD2 cause the combined deficiency of FV and FVIII (F5F8D). LMAN1 and MCFD2 form a protein complex that transports FV and FVIII from the endoplasmic reticulum to the Golgi. Although both proteins are required for the cargo receptor function, little is known about the specific roles of LMAN1 and MCFD2 in transporting FV/FVIII. We used different LMAN1 and MCFD2 deficient cell lines to investigate the LMAN1/MCFD2-dependent FV/FVIII secretion pathway. LMAN1 deficiency led to more profound decreases in FV/FVIII secretion in HEK293T and HepG2 cells than in HCT116 cells, suggesting regulation of cargo transport by the LMAN1/MCFD2 pathway varies in different cell types. Using these cell lines, we developed functional assays to accurately assess the pathogenicity of recently reported potential LMAN1 and MCFD2 missense mutations. LMAN1 with mutations abolishing carbohydrate binding can still partially rescue FV/FVIII secretion, suggesting that N-glycan binding is not essential for FV/FVIII transport. Surprisingly, overexpression of either WT or mutant MCFD2 is sufficient to rescue FV/FVIII secretion defects in LMAN1 deficient cells. These results suggest that cargo binding and transport are carried out by MCFD2 and that LMAN1 primarily serves as a shuttling carrier of MCFD2. Finally, overexpression of both LMAN1 and MCFD2 does not further increase FV/FVIII secretion, suggesting that the amount of the LMAN1-MCFD2 receptor complex is not a rate-limiting factor in ER-Golgi transport of FV/FVIII. This study provides new insight into the molecular mechanism of F5F8D and the intracellular trafficking of FV and FVIII. + Copyright © 2022 American Society of Hematology. + + + + Zhang + Yuan + Y + + Cleveland Clinic Foundation Lerner Research Inst., Cleveland, Ohio, United States. + + + + Liu + Zhigang + Z + + Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, United States. + + + + Zhang + Bin + B + + Cleveland Clinic Foundation Lerner Research Inst., Cleveland, Ohio, United States. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + Blood Adv + 101698425 + 2473-9529 + + IM +
+ + + + 2022 + 12 + 03 + + + 2022 + 08 + 19 + + + 2022 + 12 + 02 + + + 2022 + 12 + 9 + 13 + 43 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36490287 + 493436 + 10.1182/bloodadvances.2022008788 + + +
+ + + 36490293 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Prevalence of childhood anemia: Potential sociodemographic and dietary factors in Nigeria. + + e0278952 + + 10.1371/journal.pone.0278952 + + Childhood anemia is a global public health issue. In this study, we assessed the potential sociodemographic and dietary factors associated with the prevalence of anemia among children aged 6-59 months in Nigeria. + In this cross-sectional study, we collected dietary information and demographic data on 6,338 children with anemia from the Nigerian Demographic and Health Surveys (2018). The association between the occurrence of anemia and the demographic and dietary factors was determined by conducting Chi-squared tests. Additionally, bivariate and multivariate order logit models were constructed and reported as odds ratios. + The results of the multivariate analysis showed that the risk of anemia was reduced by 13% and 44% in children aged 13-36 months (OR = 0.87; 95% CI = 0.77-0.98; p = 0.019) and 37-59 months (OR = 0.56; 95% CI = 0.49-0.63; p < 0.001), respectively, compared to the risk of anemia in children aged 6-12 months. Anemia was 28% less likely in children of non-anemic mothers (OR = 0.72; 95% CI = 0.66-0.80; p < 0.001) than children of anemic mothers. Children fed pumpkin, carrot, squash, and sweet potato showed a lower occurrence of anemia by 17% (OR = 0.83; 95% CI = 0.70-0.99; p = 0.036) compared to those who were not fed these vegetables. Chances of anemia increased by 14% in children who were fed white potatoes, white yams, manioc, cassava, and other root-based foods (OR = 1.14; 95% CI = 1.01-1.29; p = 0.036). + This study highlighted the impact of a plant-based diet on the high prevalence of childhood anemia in Nigeria. Therefore, reformation of dietary habits, the inclusion of nutritional supplements, and food-fortification programs with reductions in maternal anemia are recommended. + Copyright: © 2022 Shourove et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Shourove + Jahid Hasan + JH + https://orcid.org/0000-0002-6706-6333 + + Food Engineering and Tea Technology, Shahjalal University of Science and Technology, Sylhet, Bangladesh. + + + + Meem + Fariha Chowdhury + FC + https://orcid.org/0000-0001-6506-8506 + + Food Engineering and Tea Technology, Shahjalal University of Science and Technology, Sylhet, Bangladesh. + + + + Lima + Sabrina Akther + SA + + Rajshahi Medical College, Rajshahi, Bangladesh. + + + + Islam + G M Rabiul + GMR + https://orcid.org/0000-0001-7748-4160 + + Food Engineering and Tea Technology, Shahjalal University of Science and Technology, Sylhet, Bangladesh. + + + Harvard T.H. Chan School of Public Health, Harvard University, Cambridge, MA, United States of America. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 07 + 14 + + + 2022 + 11 + 28 + + + 2022 + 12 + 9 + 13 + 43 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490293 + 10.1371/journal.pone.0278952 + PONE-D-22-19930 + + +
+ + + 36490290 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Legacies of domestication, Neolithic diffusion and trade between Indian subcontinent and Island Southeast Asia shape maternal genetic diversity of Andaman cattle. + + e0278681 + + 10.1371/journal.pone.0278681 + + Andaman cattle is a precious indigenous livestock species endemic to Andaman and Nicobar Islands, India. Till date, origin and genetic makeup of the breed which is warranted for breed conservation is not known. Moreover, the spread of zebu cattle from Indus valley to different parts of Island Southeast Asia (ISEA) is not properly understood. Here, we report the genetic diversity, population structure of Andaman cattle and their evolution in the context of epicentre of zebu domestication and ISEA. High genetic diversity in complete mitochondrial D-loop sequences indicated the ability of the breed to withstand impending climate change. Total 81 haplotypes were detected and all of them except three belonged to Bos indicus. The presence of taurine haplotypes in Andaman cattle indicate introgression by European-derived cattle. A poor phylogenetic signal of Andaman cattle with genetic affinities with cattle of Indian subcontinent and ISEA was observed. The poor phylogenetic structure may be due to multidirectional gene flow from Indian subcontinent and ISEA, with which Andaman shares a close cultural and trade relationship from Neolithic age. We hypothesize that Andaman cattle is the outcome of Neolithic diffusion from centre of zebu domestication along with multidirectional commercial exchange between Indian subcontinent and ISEA. + Copyright: © 2022 De et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + De + Arun Kumar + AK + https://orcid.org/0000-0003-0083-9300 + + Animal Science Division, ICAR-Central Island Agricultural Research Institute, Port Blair, Andaman and Nicobar Islands, India. + + + + Sawhney + Sneha + S + + Animal Science Division, ICAR-Central Island Agricultural Research Institute, Port Blair, Andaman and Nicobar Islands, India. + + + + Muthiyan + Ramachandran + R + + Animal Science Division, ICAR-Central Island Agricultural Research Institute, Port Blair, Andaman and Nicobar Islands, India. + + + + Bhattacharya + Debasis + D + + Animal Science Division, ICAR-Central Island Agricultural Research Institute, Port Blair, Andaman and Nicobar Islands, India. + + + + Ponraj + Perumal + P + + Animal Science Division, ICAR-Central Island Agricultural Research Institute, Port Blair, Andaman and Nicobar Islands, India. + + + + Malakar + Dhruba + D + + Animal Biotechnology Centre, National Dairy Research Institute, Karnal, Haryana, India. + + + + Sunder + Jai + J + + Animal Science Division, ICAR-Central Island Agricultural Research Institute, Port Blair, Andaman and Nicobar Islands, India. + + + + Sujatha + T + T + + Animal Science Division, ICAR-Central Island Agricultural Research Institute, Port Blair, Andaman and Nicobar Islands, India. + + + + Kumar + Ashish + A + + CTARA, IIT Bombay, Mumbai, Maharashtra, India. + + + + Mondal + Samiran + S + + Department of Veterinary Pathology, West Bengal University of Animal and Fishery Sciences, Kolkata, West Bengal, India. + + + + Bera + Asit Kumar + AK + + Reservoir and Wetland Fisheries Division, ICAR-Central Inland Fishery Research Institute, Barrackpore, Kolkata, West Bengal, India. + + + + Bala + P A + PA + + Animal Science Division, ICAR-Central Island Agricultural Research Institute, Port Blair, Andaman and Nicobar Islands, India. + + + + Chakurkar + Eaknath B + EB + + Animal Science Division, ICAR-Central Island Agricultural Research Institute, Port Blair, Andaman and Nicobar Islands, India. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 04 + 21 + + + 2022 + 11 + 22 + + + 2022 + 12 + 9 + 13 + 43 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490290 + 10.1371/journal.pone.0278681 + PONE-D-22-11680 + + +
+ + + 36490295 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Imputation methods for missing failure times in recurrent-event survival analysis: Application to suicide attempts in the transgender population. + + e0278913 + + 10.1371/journal.pone.0278913 + + Suicide risk among transgender populations is an important public health issue. In a project evaluating association between gender affirmation and suicide attempts in the US Transgender Survey, we evaluated the relationship between gender affirmation and risk for suicide attempts. One of the challenges is that the age at suicide attempts was only collected for the first and last attempt. The initial zero-inflated negative binomial model enabled us to evaluate the association between gender affirmation and number of suicide attempts per 5 years adjusting for other covariates. However, ignoring missing failure times of recurrent events may have caused bias and loss of efficiency. In this paper, we use a recurrent-event survival analysis incorporating time-varying covariates with three approaches to impute the age at suicide attempt, estimates from three imputation approaches are similar. We were able to confirm the findings from the initial model and identify additional associations that were not detected in the initial analysis. Findings suggest the need to consider additional analytical approaches in settings with high data missingness by design. Research to validate and compare measures that ask first and last attempt to those which enumerate all attempts in this population will be important for future surveys. + Copyright: © 2022 Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Liu + Shanshan + S + https://orcid.org/0000-0002-3596-1827 + + Biostatistics and Research Design Center, Institutional Centers for Clinical and Translational Research, Boston Children's Hospital, Boston, Massachusetts, United States of America. + + + + Reisner + Sari L + SL + + Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Boston, Massachusetts, United States of America. + + + Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America. + + + Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America. + + + The Fenway Institute, Fenway Health, Boston, Massachusetts, United States of America. + + + + Herman + Jody L + JL + + Williams Institute, School of Law, University of California, Los Angeles, Los Angeles, California, United States of America. + + + + Weller + Edie + E + + Biostatistics and Research Design Center, Institutional Centers for Clinical and Translational Research, Boston Children's Hospital, Boston, Massachusetts, United States of America. + + + Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, United States of America. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 05 + 08 + + + 2022 + 11 + 23 + + + 2022 + 12 + 9 + 13 + 43 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490295 + 10.1371/journal.pone.0278913 + PONE-D-22-13479 + + +
+ + + 36490296 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Costs, effectiveness, and safety associated with Chimeric Antigen Receptor (CAR) T-cell therapy: Results from a comprehensive cancer center. + + e0278950 + + 10.1371/journal.pone.0278950 + + Real world effectiveness, toxicity and costs analyses from chimeric antigen receptor (CAR)-T cell therapy are of utmost relevance to determine whether and how to offer patients highly personalized immunotherapy. In this study, we aimed at describing CAR T-cells effectiveness, safety and costs in a Portuguese Comprehensive Cancer Center. We performed a retrospective descriptive study of adult patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL), primary mediastinal B-cell lymphoma and transformed follicular lymphoma referred to CAR T-cell therapy, between May 2019 and February 2021. Rates of treatment response, toxicity and survival (Kaplan-Meier method) were analyzed by intention-to-treat. Direct medical costs stratified by inpatient-care, outpatient-care, and diagnostic-therapeutic procedures (DTP) were derived based on resources used and their respective unit costs. In twenty patients (median age 49.5y; 55%male; 70%DLBCL; 50% with primary refractory disease), best overall and complete response rates were 65.0% and 45.0%, respectively. Median overall (OS) and progression-free survivals were 9.2 and 7.3 months; 12-month OS rate was 42.6% (95%CI:23.2-78.3). Grade≥3 cytokine release syndrome and neurotoxicity occurred in 5.6% and 11.1% of patients, respectively. CAR T-cell therapy expenditure, including adverse events costs, was 7 176 196€, or 286 238€ when excluding drug cost. Median cost for treated patient was 355 165€ with CAR T-cell drug cost accounting for 97.0% of the overall expense. Excluding CAR T-cell acquisition cost, inpatient-care and DTP accounted for 57% and 38% of total cost/patient, respectively. Our findings highlight the heavy economic burden of CAR T-cell therapy driven by drug acquisition costs. + Copyright: © 2022 Chacim et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Chacim + Sérgio + S + + Department of Onco-hematology, Portuguese Oncology Institute of Porto (IPO-Porto), Porto, Portugal. + + + Cancer Biology and Epigenetics Group, Portuguese Oncology Institute of Porto Research Center (CI-IPOP) / RISE@CI-IPOP (Health Research Network) / Porto Comprehensive Cancer Center (Porto.CCC), Porto, Portugal. + + + + Monjardino + Teresa + T + https://orcid.org/0000-0003-4944-3366 + + Cancer Epidemiology Group, Portuguese Oncology Institute of Porto Research Center (CI-IPOP) / RISE@CI-IPOP (Health Research Network) / Porto Comprehensive Cancer Center (Porto.CCC), Porto, Portugal. + + + + Cunha + José Luís + JL + + Outcomes Research Lab, Portuguese Oncology Institute of Porto (IPO-Porto), Porto, Portugal. + + + Management, Outcomes Research, and Economics in Healthcare Group, Portuguese Oncology Institute of Porto Research Center (CI-IPOP) / RISE@CI-IPOP (Health Research Network) / Porto Comprehensive Cancer Center (Porto.CCC), Porto, Portugal. + + + + Medeiros + Pedro + P + + Outcomes Research Lab, Portuguese Oncology Institute of Porto (IPO-Porto), Porto, Portugal. + + + Management, Outcomes Research, and Economics in Healthcare Group, Portuguese Oncology Institute of Porto Research Center (CI-IPOP) / RISE@CI-IPOP (Health Research Network) / Porto Comprehensive Cancer Center (Porto.CCC), Porto, Portugal. + + + Medicine and Oncological Medicine Departments Management, Portuguese Oncology Institute of Porto (IPO-Porto), Porto, Portugal. + + + + Redondo + Patrícia + P + + Outcomes Research Lab, Portuguese Oncology Institute of Porto (IPO-Porto), Porto, Portugal. + + + Management, Outcomes Research, and Economics in Healthcare Group, Portuguese Oncology Institute of Porto Research Center (CI-IPOP) / RISE@CI-IPOP (Health Research Network) / Porto Comprehensive Cancer Center (Porto.CCC), Porto, Portugal. + + + + Bento + Maria José + MJ + + Cancer Epidemiology Group, Portuguese Oncology Institute of Porto Research Center (CI-IPOP) / RISE@CI-IPOP (Health Research Network) / Porto Comprehensive Cancer Center (Porto.CCC), Porto, Portugal. + + + Department of Epidemiology, Portuguese Oncology Institute of Porto (IPO-Porto), Porto, Portugal. + + + Department of Population Studies, ICBAS-School of Medicine and Biomedical Sciences, University of Porto (ICBAS-UP), Porto, Portugal. + + + + Mariz + José Mário + JM + + Department of Onco-hematology, Portuguese Oncology Institute of Porto (IPO-Porto), Porto, Portugal. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 06 + 28 + + + 2022 + 11 + 24 + + + 2022 + 12 + 9 + 13 + 43 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490296 + 10.1371/journal.pone.0278950 + PONE-D-22-18355 + + +
+ + + 36490301 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + The impacts of improvements in the unified economic and environmental efficiency of transportation infrastructure on industrial structure transformation and upgrade from the perspective of resource factors. + + e0278722 + + 10.1371/journal.pone.0278722 + + As an important part of a modern economic system, a modern industrial system is the key to promoting high-quality economic development. China's modern industrial system construction focuses on industrial restructuring. At present, in order to strengthen the support and leading role of transportation in the modern economic system, China is actively promoting the construction of a competitive transportation power. Therefore, it is necessary to study whether large-scale investment in transportation infrastructure can promote industrial structure transformation and upgrade. This paper takes China as the research background. Firstly, a RAM model was employed to evaluate the unified economic and environmental efficiency of transportation infrastructure that measures the level of transportation infrastructure investment. Secondly, a PVAR model was built to evaluate the dynamic effects of transportation infrastructure investment on industrial structure transformation and upgrade. Finally, from the perspective of rational flow and optimal allocation of resource factors, the paper points out that transportation infrastructure investment can indirectly promote industrial structure transformation and upgrade through three paths, namely expanding market demand, reducing resource misallocation and increasing technological innovation, and the first half of these paths are positively regulated by policies. Then, an empirical test was done with the moderated mediation model. Research findings suggest that: first, improvements in the unified economic and environmental efficiency of transportation infrastructure can only promote industrial structure supererogation in a short time, but have no significant effect on promoting industrial structure rationalization in the short or long term. Second, in actual situation, transportation infrastructure investment can promote industrial structure transformation and upgrade only by expanding market demand and technological innovation, but not by reducing resource misallocation. Third, the first half of these paths through which transportation infrastructure investment promotes industrial structure transformation and upgrade are positively regulated by policies. This paper provided some theoretical reference for promoting industrial structure transformation and upgrade by virtue of the sustainable development of transportation. + Copyright: © 2022 Yijiao Wang. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Wang + Yijiao + Y + https://orcid.org/0000-0002-8215-477X + + School of Business, Xi'an University of Finance and Economics, Xi'an, Shaanxi, China. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 08 + 08 + + + 2022 + 11 + 21 + + + 2022 + 12 + 9 + 13 + 44 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490301 + 10.1371/journal.pone.0278722 + PONE-D-22-22250 + + +
+ + + 36490291 + + 2022 + 12 + 09 + +
+ + 1520-5851 + + + 2022 + Dec + 09 + + + Environmental science & technology + Environ Sci Technol + + Improving Building Envelope Efficiency Lowers Costs and Emissions from Rural Residential Heating in China. + 10.1021/acs.est.2c06863 + + In 2017, the Chinese government launched a clean heating campaign that replaced millions of rural coal stoves with various clean heaters. The clean heating program contributed to remarkable improvements in air quality. However, the benefits of reducing heating demand by improving building envelope efficiency were not sufficiently considered. This study provides a needed quantitative assessment of potential energy-savings, costs, greenhouse gas emission reductions, and adoption strategies for improving building envelope efficiency in Chinese rural residential buildings. We find that different strategies must be employed in existing and new buildings to achieve desired outcomes. For existing buildings, to encourage easy and beneficial building retrofits (e.g., air sealing, efficient windows), current fuel subsidies should be replaced with retrofit subsidies. Building retrofits can reduce the size and hence capital costs of new clean heaters. They can also reduce operating costs, hence reducing the likelihood of backsliding to coal. For new construction, whole-home insulation and heat pumps would best avoid carbon lock-in. These efficient technologies have high upfront costs but decrease heating costs and significantly reduce carbon emissions relative to current policies. Hence, subsidies and policies that encourage improvements in building envelopes as well as the uptake of clean and efficient heaters are critical. + + + + Liu + Shangwei + S + 0000-0003-4106-3959 + + Princeton School of Public and International Affairs, Princeton University, Princeton, New Jersey 08544, United States. + + + + Liu + Hongxun + H + + School of Economics and Finance, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, China. + + + + Mauzerall + Denise L + DL + 0000-0003-3479-1798 + + Princeton School of Public and International Affairs, Princeton University, Princeton, New Jersey 08544, United States. + + + Department of Civil and Environmental Engineering, Princeton University, Princeton, New Jersey 08544, United States. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + Environ Sci Technol + 0213155 + 0013-936X + + IM + + Building + China + Emissions + Energy Efficiency + Heating + +
+ + + + 2022 + 12 + 9 + 13 + 43 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36490291 + 10.1021/acs.est.2c06863 + + +
+ + + 36490294 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Classifying tasks performed by electrical line workers using a wrist-worn sensor: A data analytic approach. + + e0261765 + + 10.1371/journal.pone.0261765 + + Electrical line workers (ELWs) experience harsh environments, characterized by long shifts, remote operations, and potentially risky tasks. Wearables present an opportunity for unobtrusive monitoring of productivity and safety. A prerequisite to monitoring is the automated identification of the tasks being performed. Human activity recognition has been widely used for classification for activities of daily living. However, the literature is limited for electrical line maintenance/repair tasks due to task variety and complexity. We investigated how features can be engineered from a single wrist-worn accelerometer for the purpose of classifying ELW tasks. Specifically, three classifiers were investigated across three feature sets (time, frequency, and time-frequency) and two window lengths (4 and 10 seconds) to identify ten common ELW tasks. Based on data from 37 participants in a lab environment, two application scenarios were evaluated: (a) intra-subject, where individualized models were trained and deployed for each worker; and (b) inter-subject, where data was pooled to train a general model that can be deployed for new workers. Accuracies ≥ 93% were achieved for both scenarios, and increased to ≥96% with 10-second windows. Overall and class-specific feature importance were computed, and the impact of those features on the obtained predictions were explained. This work will contribute to the future risk mitigation of ELWs using wearables. + Copyright: © 2022 Ragani Lamooki et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Ragani Lamooki + Saeb + S + + Mechanical and Aerospace Engineering, University at Buffalo, Buffalo, NY, United States of America. + + + + Hajifar + Sahand + S + + Industrial and Systems Engineering, University at Buffalo, Buffalo, NY, United States of America. + + + + Hannan + Jacqueline + J + + Biomedical Engineering, University at Buffalo, Buffalo, NY, United States of America. + + + + Sun + Hongyue + H + + Industrial and Systems Engineering, University at Buffalo, Buffalo, NY, United States of America. + + + + Megahed + Fadel + F + https://orcid.org/0000-0003-2194-5110 + + Farmer School of Business, Miami University, Oxford, OH, United States of America. + + + + Cavuoto + Lora + L + https://orcid.org/0000-0003-4717-8378 + + Industrial and Systems Engineering, University at Buffalo, Buffalo, NY, United States of America. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2021 + 04 + 23 + + + 2021 + 12 + 09 + + + 2022 + 12 + 9 + 13 + 43 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490294 + 10.1371/journal.pone.0261765 + PONE-D-21-13597 + + +
+ + + 36490289 + + 2022 + 12 + 09 + +
+ + 2373-8227 + + + 2022 + Dec + 09 + + + ACS infectious diseases + ACS Infect Dis + + Optical Spectrophotometry as a Promising Method for Quantification and Stage Differentiation of Plasmodium falciparum Parasites. + 10.1021/acsinfecdis.2c00484 + + Malaria is one of the most life-threatening infectious diseases worldwide, claiming half a million lives yearly. Prompt and accurate diagnosis is crucial for disease control and elimination. Currently used diagnostic methods require blood sampling and fail to detect low-level infections. At the symptomatic stage of infection, the parasites feed on red blood cells' (RBCs) hemoglobin, forming inert crystals, the hemozoin, in the process. Thus, along with parasite maturation inside the RBCs, the hemoglobin and hemozoin proportion is inversely related, and they generate specific optical spectra, according to their concentration. Herein, to address the issues of finger prick sampling and the lack of sensitivity of the parasitological test, we explored the optical features of Plasmodium falciparum-infected RBCs through absorbance and reflectance spectrophotometric characterization, aiming for their detection. This is the first work fully characterizing the spectrophotometric properties of P. falciparum-infected RBCs by using only 16 specific wavelengths within the visible optical spectra and two different post-processing algorithms. With such an innovative methodology, low-level infections can be detected and quantified, and early- and late-stage development can be clearly distinguished, not only improving the current detection limits but also proving the successful applicability of spectrophotometry for competitive and accurate malaria diagnosis. + + + + Baptista + Vitória + V + + Microelectromechanical Systems Research Unit (CMEMS-UMinho), School of Engineering, University of Minho, Campus de Azurém, 4800-058 Guimarães, Portugal. + + + LABBELS─Associate Laboratory, 4800-058 Braga/Guimarães, Portugal. + + + Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal. + + + ICVS/3B's─PT Government Associate Laboratory, 4806-909 Guimarães, Braga/, Portugal. + + + + Silva + Miguel + M + + Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal. + + + ICVS/3B's─PT Government Associate Laboratory, 4806-909 Guimarães, Braga/, Portugal. + + + + Ferreira + Gabriel M + GM + + Microelectromechanical Systems Research Unit (CMEMS-UMinho), School of Engineering, University of Minho, Campus de Azurém, 4800-058 Guimarães, Portugal. + + + LABBELS─Associate Laboratory, 4800-058 Braga/Guimarães, Portugal. + + + + Calçada + Carla + C + + Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal. + + + ICVS/3B's─PT Government Associate Laboratory, 4806-909 Guimarães, Braga/, Portugal. + + + + Minas + Graça + G + 0000-0003-2460-0556 + + Microelectromechanical Systems Research Unit (CMEMS-UMinho), School of Engineering, University of Minho, Campus de Azurém, 4800-058 Guimarães, Portugal. + + + LABBELS─Associate Laboratory, 4800-058 Braga/Guimarães, Portugal. + + + + Veiga + Maria Isabel + MI + + Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal. + + + ICVS/3B's─PT Government Associate Laboratory, 4806-909 Guimarães, Braga/, Portugal. + + + + Catarino + Susana O + SO + 0000-0002-8962-0710 + + Microelectromechanical Systems Research Unit (CMEMS-UMinho), School of Engineering, University of Minho, Campus de Azurém, 4800-058 Guimarães, Portugal. + + + LABBELS─Associate Laboratory, 4800-058 Braga/Guimarães, Portugal. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + ACS Infect Dis + 101654580 + 2373-8227 + + IM + + absorbance + diagnosis + hemoglobin + hemozoin + malaria + reflectance + spectrophotometry + +
+ + + + 2022 + 12 + 9 + 13 + 43 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36490289 + 10.1021/acsinfecdis.2c00484 + + +
+ + + 36490303 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + The influence of race tactics for performance in the heats of an international sprint cross-country skiing competition. + + e0278552 + + 10.1371/journal.pone.0278552 + + The purpose of this study was to examine the influence of race tactics for performance in the heats of an international sprint cross-country (XC) skiing competition in the classical style. Thirty elite male XC skiers (age: 24±3 years, sprint International Ski Federation [FIS] points: 61±27) performed a sprint time-trial (STT) followed by one to three 'knock-out' heats on a 1.7 km racecourse. An integrated GNSS/IMU system was used to determine position, sub-technique distribution and kinematics. Positioning was analysed using the television broadcast of the race. STT rank correlated positively with the final rank [(rs (28) = .72, P = .001)]. The top-two finishers in each heat were on average ~3.8% slower in the heats compared to the STT (237.1±3.9 vs. 228.3±4.0 seconds, P = .001). On average, the skiers performed ~10 overtakings per 100 meters from the start to the last uphill segment but only ~3 overtakings per 100 meters in the last two segments in each heat. 93.8% of the top-two finishing skiers positioned themselves at top 2 before approaching the final uphill, in which the top-two finishers and the skiers ranked 3-4 were generally faster than those ranked 5-6 in the heats (both, P = .01). Here, top-four skiers employed 5.3% longer cycle lengths and 3.4% higher cycle rates in the diagonal sub-technique than skiers ranked 5-6 (all, P = .01). The present study demonstrates the importance of race tactics for performance in the heats of sprint XC skiing, in which the main performance-determining factors in the present racecourse were a front position when approaching the final uphill segment combined with the ability to ski fast in that segment. In general, this illustrates how accurate racecourse analyses may help skiers to optimize their race-individual race-strategies in the heats of sprint XC skiing competitions. + Copyright: © 2022 Haugnes et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Haugnes + Pål + P + https://orcid.org/0000-0003-0497-6230 + + Centre for Elite Sports Research, Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway. + + + + Kocbach + Jan + J + + Centre for Elite Sports Research, Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway. + + + NORCE Norwegian Research Centre AS, Bergen, Norway. + + + + Talsnes + Rune Kjøsen + RK + + Department of Sports Science and Physical Education, Nord University, Bodø, Norway. + + + + Noordhof + Dionne + D + + Centre for Elite Sports Research, Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway. + + + + Ettema + Gertjan + G + + Centre for Elite Sports Research, Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway. + + + + Sandbakk + Øyvind + Ø + https://orcid.org/0000-0002-9014-5152 + + Centre for Elite Sports Research, Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 06 + 15 + + + 2022 + 11 + 18 + + + 2022 + 12 + 9 + 13 + 44 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490303 + 10.1371/journal.pone.0278552 + PONE-D-22-17184 + + +
+ + + 36490288 + + 2022 + 12 + 09 + +
+ + 1098-2272 + + + 2022 + Dec + 09 + + + Genetic epidemiology + Genet Epidemiol + + Efficient identification of trait-associated loss-of-function variants in the UK Biobank cohort by exome-sequencing based genotype imputation. + 10.1002/gepi.22511 + + The large-scale open access whole-exome sequencing (WES) data of the UK Biobank ~200,000 participants is accelerating a new wave of genetic association studies aiming to identify rare and functional loss-of-function (LoF) variants associated with complex traits and diseases. We proposed to merge the WES genotypes and the genome-wide genotyping (GWAS) genotypes of 167,000 UKB homogeneous European participants into a combined reference panel, and then to impute 241,911 UKB homogeneous European participants who had the GWAS genotypes only. We then used the imputed data to replicate association identified in the discovery WES sample. The average imputation accuracy measure r2 is modest to high for LoF variants at all minor allele frequency intervals: 0.942 at MAF interval (0.01, 0.5), 0.807 at (1.0 × 10-3 , 0.01), 0.805 at (1.0 × 10-4 , 1.0 × 10-3 ), 0.664 at (1.0 × 10-5 , 1.0 × 10-4 ) and 0.410 at (0, 1.0 × 10-5 ). As applications, we studied associations of LoF variants with estimated heel BMD and four lipid traits. In addition to replicating dozens of previously reported genes, we also identified three novel associations, two genes PLIN1 and ANGPTL3 for high-density-lipoprotein cholesterol and one gene PDE3B for triglycerides. Our results highlighted the strength of WES based genotype imputation as well as provided useful imputed data within the UKB cohort. + © 2022 Wiley Periodicals LLC. + + + + Yu + Wen-Yuan + WY + + Department of Plastic Surgery, The Second Affiliated Hospital of Soochow University, Jiangsu, People's Republic of China. + + + Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College of Soochow University, Jiangsu, People's Republic of China. + + + + Yan + Shan-Shan + SS + + Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College of Soochow University, Jiangsu, People's Republic of China. + + + Department of Epidemiology and Health Statistics, School of Public Health, Medical College of Soochow University, Jiangsu, People's Republic of China. + + + + Zhang + Shu-Han + SH + + Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College of Soochow University, Jiangsu, People's Republic of China. + + + Department of Epidemiology and Health Statistics, School of Public Health, Medical College of Soochow University, Jiangsu, People's Republic of China. + + + + Ni + Jing-Jing + JJ + + Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College of Soochow University, Jiangsu, People's Republic of China. + + + Center for Genetic Epidemiology and Genomics, School of Public Health, Medical College of Soochow University, Jiangsu, People's Republic of China. + + + + Bin-Li + + Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College of Soochow University, Jiangsu, People's Republic of China. + + + Department of General Surgery, The Ninth Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People's Republic of China. + + + + Pei + Yu-Fang + YF + + Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College of Soochow University, Jiangsu, People's Republic of China. + + + Department of Epidemiology and Health Statistics, School of Public Health, Medical College of Soochow University, Jiangsu, People's Republic of China. + + + + Zhang + Lei + L + http://orcid.org/0000-0002-1007-4834 + + Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College of Soochow University, Jiangsu, People's Republic of China. + + + Center for Genetic Epidemiology and Genomics, School of Public Health, Medical College of Soochow University, Jiangsu, People's Republic of China. + + + + eng + + + National Natural Science Foundation of China + + + + Priority Academic Program Development of Jiangsu Higher Education Institutions + + + + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + Genet Epidemiol + 8411723 + 0741-0395 + + IM + + UK biobank cohort + genotype imputation + lipid traits + loss-of-function + whole exome sequencing + +
+ + + + 2022 + 11 + 22 + + + 2022 + 03 + 20 + + + 2022 + 11 + 28 + + + 2022 + 12 + 9 + 13 + 43 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36490288 + 10.1002/gepi.22511 + + + REFERENCES + + Barton, A. R., Sherman, M. A., Mukamel, R. E., & Loh, P. R. (2021). Whole-exome imputation within UK Biobank powers rare coding variant association and fine-mapping analyses. Nature Genetics, 53(8), 1260-1269. https://doi.org/10.1038/s41588-021-00892-1 + + + Das, S., Abecasis, G. R., & Browning, B. L. (2018). Genotype imputation from large reference panels. Annual Review of Genomics and Human Genetics, 19, 73-96. https://doi.org/10.1146/annurev-genom-083117-021602 + + + Das, S., Forer, L., Schönherr, S., Sidore, C., Locke, A. E., Kwong, A., Vrieze, S. I., Chew, E. Y., Levy, S., McGue, M., Schlessinger, D., Stambolian, D., Loh, P. R., Iacono, W. G., Swaroop, A., Scott, L. J., Cucca, F., Kronenberg, F., Boehnke, M., … Fuchsberger, C. (2016). Next-generation genotype imputation service and methods. Nature Genetics, 48(10), 1284-1287. https://doi.org/10.1038/ng.3656 + + + David, C. H. (2003). John W. Tukey and data analysis. Statistical Science, 18(3), 311-318. https://doi.org/10.1214/ss/1076102418 + + + Delaneau, O., Marchini, J., & Zagury, J. F. (2011). A linear complexity phasing method for thousands of genomes. Nature Methods, 9(2), 179-181. https://doi.org/10.1038/nmeth.1785 + + + Finucane, H. K., Bulik-Sullivan, B., Gusev, A., Trynka, G., Reshef, Y., Loh, P. R., Anttila, V., Xu, H., Zang, C., Farh, K., Ripke, S., Day, F. R., Purcell, S., Stahl, E., Lindstrom, S., Perry, J. R. B., Okada, Y., Raychaudhuri, S., Daly, M. J., … Price, A. L. (2015). Partitioning heritability by functional annotation using genome-wide association summary statistics. Nature Genetics, 47(11), 1228-1235. https://doi.org/10.1038/ng.3404 + + + Hormozdiari, F., Zhu, A., Kichaev, G., Ju, C. J. T., Segrè, A. V., Joo, J. W. J., Won, H., Sankararaman, S., Pasaniuc, B., Shifman, S., & Eskin, E. (2017). Widespread allelic heterogeneity in complex traits. The American Journal of Human Genetics, 100(5), 789-802. https://doi.org/10.1016/j.ajhg.2017.04.005 + + + Van Hout, C. V., Tachmazidou, I., Backman, J. D., Hoffman, J. D., Liu, D., Pandey, A. K., Gonzaga-Jauregui, C., Khalid, S., Ye, B., Banerjee, N., Li, A. H., O'Dushlaine, C., Marcketta, A., Staples, J., Schurmann, C., Hawes, A., Maxwell, E., Barnard, L., Lopez, A., … Baras, A. (2020). Exome sequencing and characterization of 49,960 individuals in the UK Biobank. Nature, 586(7831), 749-756. https://doi.org/10.1038/s41586-020-2853-0 + + + Howie, B., Fuchsberger, C., Stephens, M., Marchini, J., & Abecasis, G. R. (2012). Fast and accurate genotype imputation in genome-wide association studies through pre-phasing. Nature Genetics, 44(8), 955-959. https://doi.org/10.1038/ng.2354 + + + Karczewski, K. J., Francioli, L. C., Tiao, G., Cummings, B. B., Alföldi, J., Wang, Q., Collins, R. L., Laricchia, K. M., Ganna, A., Birnbaum, D. P., Gauthier, L. D., Brand, H., Solomonson, M., Watts, N. A., Rhodes, D., Singer-Berk, M., England, E. M., Seaby, E. G., Kosmicki, J. A., … Salomaa, V. (2020). The mutational constraint spectrum quantified from variation in 141,456 humans. Nature, 581(7809), 434-443. https://doi.org/10.1038/s41586-020-2308-7 + + + Kemp, J. P., Morris, J. A., Medina-Gomez, C., Forgetta, V., Warrington, N. M., Youlten, S. E., Zheng, J., Gregson, C. L., Grundberg, E., Trajanoska, K., Logan, J. G., Pollard, A. S., Sparkes, P. C., Ghirardello, E. J., Allen, R., Leitch, V. D., Butterfield, N. C., Komla-Ebri, D., Adoum, A. T., … Evans, D. M. (2017). Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis. Nature Genetics, 49(10), 1468-1475. https://doi.org/10.1038/ng.3949 + + + Kimmel, A. R., Brasaemle, D. L., McAndrews-Hill, M., Sztalryd, C., & Londos, C. (2010). Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins. Journal of Lipid Research, 51(3), 468-471. https://doi.org/10.1194/jlr.R000034 + + + Liu, D. J., Peloso, G. M., Yu, H., Butterworth, A. S., Wang, X., Mahajan, A., Saleheen, D., Emdin, C., Alam, D., Alves, A. C., Amouyel, P., Di Angelantonio, E., Arveiler, D., Assimes, T. L., Auer, P. L., Baber, U., Ballantyne, C. M., Bang, L. E., Benn, M., … Rasheed, A. (2017). Exome-wide association study of plasma lipids in >300,000 individuals. Nature Genetics, 49(12), 1758-1766. https://doi.org/10.1038/ng.3977 + + + Manichaikul, A., Mychaleckyj, J. C., Rich, S. S., Daly, K., Sale, M., & Chen, W. M. (2010). Robust relationship inference in genome-wide association studies. Bioinformatics, 26(22), 2867-2873. https://doi.org/10.1093/bioinformatics/btq559 + + + McLaren, W., Gil, L., Hunt, S. E., Riat, H. S., Ritchie, G. R. S., Thormann, A., Flicek, P., & Cunningham, F. (2016). The ensembl variant effect predictor. Genome Biology, 17, 122. https://doi.org/10.1186/s13059-016-0974-4 + + + Medina-Gomez, C., Kemp, J. P., Trajanoska, K., Luan, J., Chesi, A., Ahluwalia, T. S., Mook-Kanamori, D. O., Ham, A., Hartwig, F. P., Evans, D. S., Joro, R., Nedeljkovic, I., Zheng, H. F., Zhu, K., Atalay, M., Liu, C. T., Nethander, M., Broer, L., Porleifsson, G., … Rivadeneira, F. (2018). Life-course genome-wide association study meta-analysis of total body BMD and assessment of age-specific effects. The American Journal of Human Genetics, 102(1), 88-102. https://doi.org/10.1016/j.ajhg.2017.12.005 + + + Morris, J. A., Kemp, J. P., Youlten, S. E., Laurent, L., Logan, J. G., Chai, R. C., Vulpescu, N. A., Forgetta, V., Kleinman, A., Mohanty, S. T., Sergio, C. M., Quinn, J., Nguyen-Yamamoto, L., Luco, A. L., Vijay, J., Simon, M. M., Pramatarova, A., Medina-Gomez, C., Trajanoska, K., … Richards, J. B. (2019). An atlas of genetic influences on osteoporosis in humans and mice. Nature Genetics, 51(2), 258-266. https://doi.org/10.1038/s41588-018-0302-x + + + Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M. A. R., Bender, D., Maller, J., Sklar, P., de Bakker, P. I. W., Daly, M. J., & Sham, P. C. (2007). PLINK: a tool set for whole-genome association and population-based linkage analyses. The American Journal of Human Genetics, 81(3), 559-575. https://doi.org/10.1086/519795 + + + Regier, A. A., Farjoun, Y., Larson, D. E., Krasheninina, O., Kang, H. M., Howrigan, D. P., Chen, B. J., Kher, M., Banks, E., Ames, D. C., English, A. C., Li, H., Xing, J., Zhang, Y., Matise, T., Abecasis, G. R., Salerno, W., Zody, M. C., Neale, B. M., & Hall, I. M. (2018). Functional equivalence of genome sequencing analysis pipelines enables harmonized variant calling across human genetics projects. Nature Communications, 9(1), 4038. https://doi.org/10.1038/s41467-018-06159-4 + + + Szustakowski, J. D., Balasubramanian, S., Kvikstad, E., Khalid, S., Bronson, P. G., Sasson, A., Wong, E., Liu, D., Wade Davis, J., Haefliger, C., Katrina Loomis, A., Mikkilineni, R., Noh, H. J., Wadhawan, S., Bai, X., Hawes, A., Krasheninina, O., Ulloa, R., Lopez, A. E., … Ye, Z. (2021). Advancing human genetics research and drug discovery through exome sequencing of the UK Biobank. Nature Genetics, 53(7), 942-948. https://doi.org/10.1038/s41588-021-00885-0 + + + Willer, C. J., Schmidt, E. M., Sengupta, S., Peloso, G. M., Gustafsson, S., Kanoni, S., & Abecasis, G. R. (2013). Discovery and refinement of loci associated with lipid levels. Nature Genetics, 45(11), 1274-1283. https://doi.org/10.1038/ng.2797 + + + Zelenchuk, L. V., Hedge, A. M., & Rowe, P. S. N. (2015). Age dependent regulation of bone-mass and renal function by the MEPE ASARM-motif. Bone, 79, 131-142. https://doi.org/10.1016/j.bone.2015.05.030 + + + Zhang, L., Pei, Y. F., Fu, X., Lin, Y., Wang, Y. P., & Deng, H. W. (2014). FISH: fast and accurate diploid genotype imputation via segmental hidden Markov model. Bioinformatics, 30(13), 1876-1883. https://doi.org/10.1093/bioinformatics/btu143 + + + Zheng, H. F., Forgetta, V., Hsu, Y. H., Estrada, K., Rosello-Diez, A., Leo, P. J., Dahia, C. L., Park-Min, K. H., Tobias, J. H., Kooperberg, C., Kleinman, A., Styrkarsdottir, U., Liu, C. T., Uggla, C., Evans, D. S., Nielson, C. M., Walter, K., Pettersson-Kymmer, U., McCarthy, S., … Evans, D. M. (2015). Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture. Nature, 526(7571), 112-117. https://doi.org/10.1038/nature14878 + + + +
+ + + 36490292 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + The development of Cognitive Behavioural Therapy (CBT) for chronic loneliness in children and young people: Protocol for a single-case experimental design. + + e0278746 + + 10.1371/journal.pone.0278746 + + Loneliness is a significant problem for young people and is associated with a range of physical and mental health difficulties. Meta-analyses have identified that interventions aimed at young people who report loneliness as their primary problem are lacking within the literature. In adults, the most effective interventions for loneliness are those which target the underlying maladaptive social cognitions. Therefore, we have developed a modular Cognitive Behavioural Therapy (CBT) intervention for children and young people. The aim of this study is to conduct a multiple baseline single-case experimental design (SCED) to assess the efficacy, feasibility and acceptability of this intervention. In total 6-8 11-18-year-olds and their families will be recruited. The design consists of AB+ post-intervention, where A is the baseline phase, B is the intervention phase and then a post-intervention phase. Participants will complete a baseline assessment, before being randomised to one of four different baseline lengths (12 days, 19 days, 26 days or 33 days). Participants will then complete an average of 12 sessions of CBT, with the aim being to reduce their feelings of loneliness. Participants will then complete a 12-day post-intervention phase. Participant loneliness will be repeatedly assessed throughout the three phases of the intervention using the Three-item Loneliness Scale, which will be the primary outcome. Secondary outcomes will be reliable and clinically meaningful change on the UCLA Loneliness Scale, Revised Child Anxiety and Depression Scale (RCADS) and Strengths and Difficulties Questionnaire (SDQ). Feasibility and participant satisfaction will also be assessed and reported. Trial registration: ClinicalTrails.gov trial registration number: NCT05149963 (Date registered: 07.12.2021). https://www.clinicaltrials.gov/ct2/show/NCT05149963?term=cbt&cond=loneliness&draw=2&rank=1. + Copyright: © 2022 Cawthorne et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Cawthorne + Tom + T + https://orcid.org/0000-0003-4537-0016 + + Royal Holloway, University of London, Egham, United Kingdom. + + + Camden and Islington NHS Foundation Trust, London, United Kingdom. + + + + Käll + Anton + A + https://orcid.org/0000-0003-1579-8791 + + Department of Behavioural Sciences and Learning, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden. + + + + Bennett + Sophie + S + + UCL Great Ormond Street Institute of Child Health, London, England. + + + + Andersson + Gerhard + G + + Department of Behavioural Sciences and Learning, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden. + + + Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden. + + + + Shafran + Roz + R + https://orcid.org/0000-0003-2729-4961 + + UCL Great Ormond Street Institute of Child Health, London, England. + + + + eng + + + ClinicalTrials.gov + + NCT05149963 + + + + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2021 + 12 + 14 + + + 2022 + 11 + 21 + + + 2022 + 12 + 9 + 13 + 43 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490292 + 10.1371/journal.pone.0278746 + PONE-D-21-39379 + + +
+ + + 36490298 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Analysis of autonomic function during natural defecation in patients with irritable bowel syndrome using real-time recording with a wearable device. + + e0278922 + + 10.1371/journal.pone.0278922 + + Autonomic dysfunction is a factor in irritable bowel syndrome (IBS). However, there are no reports of autonomic nervous system (ANS) activity during natural defecation in patients with IBS. We aimed to clarify the relationship between ANS activity and life events, such as defecation and abdominal symptoms, using real-time recording. + Six patients with IBS and 14 healthy controls were enrolled in this prospective multicenter study. ANS activity was recorded for 24 h using a T-shirt wearable device, and life events were recorded simultaneously in real time using a smartphone application software. Low frequency/high frequency (LF/HF) and HF calculated by power spectrum analysis were defined as activity indicators of the sympathetic and parasympathetic nerves, respectively. + The means of LF/HF and HF in the period with positive symptoms were comparable between the groups; however, the sum of LF/HF, sum of ΔLF/HF, and the maximum variation in ΔLF/HF were significantly higher in the IBS group. In the IBS group, the sum of ΔLF/HF and LF/HF increased significantly from 2 min before defecation, and the sum of LF/HF remained significantly higher until 9 min after defecation. The sum of ΔLF/HF at 2 min before defecation was significantly positively correlated with the intensity of abdominal pain and diarrhea and constipation scores. In contrast, it was significantly negatively correlated with defecation satisfaction and health-related quality of life. + In patients with IBS, sympathetic nerve activity was activated 2 min before defecation, which was correlated with abdominal symptoms and lower QOL. + Copyright: © 2022 Nakata et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Nakata + Rieko + R + https://orcid.org/0000-0001-9977-7239 + + Department of Gastroenterology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan. + + + + Tanaka + Fumio + F + https://orcid.org/0000-0002-9186-1249 + + Department of Gastroenterology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan. + + + + Sugawara + Noriaki + N + + Second Department of Internal Medicine, Osaka Medical and Pharmaceutical University, Takatsuki City, Osaka, Japan. + + + + Kojima + Yuichi + Y + + Second Department of Internal Medicine, Osaka Medical and Pharmaceutical University, Takatsuki City, Osaka, Japan. + + + + Takeuchi + Toshihisa + T + + Second Department of Internal Medicine, Osaka Medical and Pharmaceutical University, Takatsuki City, Osaka, Japan. + + + + Shiba + Masatsugu + M + + Department of Gastroenterology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan. + + + + Higuchi + Kazuhide + K + + Premier Departmental Research of Medicine, Osaka Medical and Pharmaceutical University, Takatsuki City, Osaka, Japan. + + + + Fujiwara + Yasuhiro + Y + + Department of Gastroenterology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 08 + 01 + + + 2022 + 11 + 23 + + + 2022 + 12 + 9 + 13 + 43 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490298 + 10.1371/journal.pone.0278922 + PONE-D-22-21544 + + +
+ + + 36490297 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Inertial imitation method of MMC with hybrid topology for VSC-HVDC. + + e0277553 + + 10.1371/journal.pone.0277553 + + A new virtual synchronous generator (VSG) control strategy was researched and proposed for a VSC-HVDC (High Voltage Direct Current Based on Voltage Source Converter) transmission system. It can be applied to half-bridge or full-half-bridge hybrid topology modular multi-level converter (MMC) to improve the stability and reliability of the system. First, it is proposed that the energy stored in the equivalent capacitor of MMC power module was used to imitate the rotor inertial of synchronous generator. It can buffer transient power fluctuations and synchronize autonomously with the grid. Then the impedance characteristics of the proposed control method have been deduced and analyzed. The results show that the VSG control loop mainly improves the low frequency characteristics of the converter. Secondly, the ability to suppress transient fault current is weak. So, a method, that the given values of inner current loop are calculated by grid impedance matrix, was used. A double closed loop control structure composed by a power outer loop based on VSG control and a current inner loop is obtained. The simulation results show that it can effectively improve the current control capability during the transient process for systems with a 1:2 ratio of converter capacity to grid capacity (The grid short-circuit capacity is 60MW and the MMC is 30 MW). Finally, a hybrid MMC simulation model was built based on PSCAD and the steady-state and transient fault ride-through simulations were performed. The power adjustment time of MMC under the proposed VSG control is about 1s, while the adjustment time under the conventional control strategy is greater than 4s. + Copyright: © 2022 Wu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Wu + Jie + J + https://orcid.org/0000-0002-4624-1251 + + The College of Information, Mechanical and Electrical Engineering, Shanghai Normal University, Shanghai, China. + + + + Yin + Shiyi + S + https://orcid.org/0000-0002-0167-3341 + + The College of Information, Mechanical and Electrical Engineering, Shanghai Normal University, Shanghai, China. + + + + Li + Chuanjiang + C + + The College of Information, Mechanical and Electrical Engineering, Shanghai Normal University, Shanghai, China. + + + + Zhang + Qiaozhen + Q + + The College of Information, Mechanical and Electrical Engineering, Shanghai Normal University, Shanghai, China. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 02 + 28 + + + 2022 + 10 + 30 + + + 2022 + 12 + 9 + 13 + 43 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490297 + 10.1371/journal.pone.0277553 + PONE-D-22-05125 + + +
+ + + 36490307 + + 2022 + 12 + 09 + +
+ + 1540-8167 + + + 2022 + Dec + 09 + + + Journal of cardiovascular electrophysiology + J Cardiovasc Electrophysiol + + Validation of the accuracy of contact force measurement by contemporary force-sensing ablation catheters. + 10.1111/jce.15770 + + Contact force-sensing catheters are widely used for ablation of cardiac arrhythmias. They allow quantification of catheter-to-tissue contact, which is an important determinant for lesion formation and may reduce the risk of complications. The accuracy of these sensors may vary across the measurement range, catheter-to-tissue angle, and amongst manufacturers and we aim to compare the accuracy and reproducibility of four different force sensing ablation catheters. + A measurement setup containing a heated saline water bath with an integrated force measurement unit was constructed and validated. Subsequently, we investigated four different catheter models, each equipped with a unique measurement technology: Tacticath Quartz (Abbott), AcQBlate Force (Biotronik/Acutus), Stablepoint (Boston Scientific), and Smarttouch SF (Biosense Webster). For each model, the accuracy of three different catheters was measured within the range of 0-60 grams and at contact angles of 0°, 30°, 45°, 60°, and 90°. + In total, 6685 measurements were performed using 4x3 catheters (median of 568, IQR 511-606 measurements per catheter). Over the entire measurement-range, the force measured by the catheters deviated from the real force by the following absolute mean values: Tacticath 1.29g ±0.99g, AcQBlate Force 2.87g ±2.37g, Stablepoint 1.38g ±1.29g, and Smarttouch 2.26g ±2.70g. For some models, significant under- and overestimation of >10g were observed at higher forces. Mean absolute errors of all models across the range of 10-40g were <3g. + Contact measured by force-sensing catheters is accurate with 1-3g deviation within the range of 10g to 40g. Significant errors can occur at higher forces with potential clinical consequences. This article is protected by copyright. All rights reserved. + This article is protected by copyright. All rights reserved. + + + + Kueffer + Thomas + T + http://orcid.org/0000-0003-3553-4945 + + Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. + + + + Haeberlin + Andreas + A + http://orcid.org/0000-0002-9283-0110 + + Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. + + + ARTORG Center for Biomedical Engineering, University of Bern, Switzerland. + + + + Knecht + Sven + S + http://orcid.org/0000-0001-7122-021X + + Department of Cardiology, University Hospital Basel, Basel, Switzerland. + + + + Baldinger + Samuel H + SH + + Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. + + + + Madaffari + Antonio + A + + Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. + + + + Seiler + Jens + J + + Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. + + + + Mühl + Aline + A + + Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. + + + + Tanner + Hildegard + H + + Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. + + + + Roten + Laurent + L + http://orcid.org/0000-0002-0827-1329 + + Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. + + + + Reichlin + Tobias + T + http://orcid.org/0000-0002-7197-8415 + + Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + J Cardiovasc Electrophysiol + 9010756 + 1045-3873 + + IM + + Catheter Ablation + Contact Force + Force Sensing + Radiofrequency Ablation + +
+ + + + 2022 + 12 + 9 + 13 + 44 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36490307 + 10.1111/jce.15770 + + +
+ + + 36490300 + + 2022 + 12 + 09 + +
+ + 1935-2735 + + 16 + 12 + + 2022 + Dec + 09 + + + PLoS neglected tropical diseases + PLoS Negl Trop Dis + + Natural statin derivatives as potential therapy to reduce intestinal fluid loss in cholera. + + e0010989 + + 10.1371/journal.pntd.0010989 + + As a leading cause of death in children under 5 years old, secretory diarrheas including cholera are characterized by excessive intestinal fluid secretion driven by enterotoxin-induced cAMP-dependent intestinal chloride transport. This study aimed to identify fungal bioactive metabolites possessing anti-secretory effects against cAMP-dependent chloride secretion in intestinal epithelial cells. Using electrophysiological analyses in human intestinal epithelial (T84) cells, five fungus-derived statin derivatives including α,β-dehydrolovastatin (DHLV), α,β-dehydrodihydromonacolin K, lovastatin, mevastatin and simvastatin were found to inhibit the cAMP-dependent chloride secretion with IC50 values of 1.8, 8.9, 11.9, 11.4 and 5 μM, respectively. Being the most potent statin derivatives, DHLV was evaluated for its pharmacological properties including cellular toxicity, mechanism of action, target specificity and in vivo efficacy. DHLV at concentrations up to 20 μM did not affect cell viability and barrier integrity of T84 cells. Electrophysiological analyses indicated that DHLV inhibited cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-dependent apical chloride channel, via mechanisms not involving alteration of intracellular cAMP levels or its negative regulators including AMP-activated protein kinases and protein phosphatases. DHLV had no effect on Na+-K+ ATPase activities but inhibited Ca2+-dependent chloride secretion without affecting intracellular Ca2+ levels. Importantly, intraperitoneal (2 mg/kg) and intraluminal (20 μM) injections of DHLV reduced cholera toxin-induced intestinal fluid secretion in mice by 59% and 65%, respectively without affecting baseline intestinal fluid transport. This study identifies natural statin derivatives as novel natural product-derived CFTR inhibitors, which may be beneficial in the treatment of enterotoxin-induced secretory diarrheas including cholera. + Copyright: © 2022 Noitem et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Noitem + Rattikarn + R + + Program in Translational Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Ratchathewi, Bangkok, Thailand. + + + Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bang Phli, Samut Prakarn, Thailand. + + + + Pongkorpsakol + Pawin + P + + Princess Srisavangavadhana College of Medicine, Chulabhorn Royal Academy, Bangkok, Thailand. + + + + Changsen + Chartchai + C + + Department of Microbiology, Faculty of Science, Mahidol University, Ratchathewi, Bangkok, Thailand. + + + + Sukpondma + Yaowapa + Y + + Division of Physical Science and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, Thailand. + + + + Tansakul + Chittreeya + C + + Division of Physical Science and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, Thailand. + + + + Rukachaisirikul + Vatcharin + V + + Division of Physical Science and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, Thailand. + + + + Muanprasat + Chatchai + C + + Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bang Phli, Samut Prakarn, Thailand. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS Negl Trop Dis + 101291488 + 1935-2727 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 05 + 26 + + + 2022 + 11 + 28 + + + 2022 + 12 + 9 + 13 + 44 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36490300 + 10.1371/journal.pntd.0010989 + PNTD-D-22-00694 + + +
+ + + 36490306 + + 2022 + 12 + 09 + +
+ + 1520-5851 + + + 2022 + Dec + 09 + + + Environmental science & technology + Environ Sci Technol + + Reduction of Dimethylarsenate to Highly Toxic Dimethylarsenite in Paddy Soil and Rice Plants. + 10.1021/acs.est.2c07418 + + Dimethylarsenate [DMAs(V)] is a common methylated As species in soils and plants and can cause the physiological disorder straighthead disease in rice. Because DMAs(V) is relatively noncytotoxic, we hypothesize that phytotoxicity of DMAs(V) may arise from trivalent dimethylarsenite [DMAs(III)]. DMAs(III) has been detected in human urine samples but not in environmental samples, likely due to its instability under oxic conditions. We first established methods for preservation and detections of DMAs(III) in soil and plant samples. We showed that DMAs(III) was a major As species in soil solution from an anoxic paddy soil. Enrichment cultures for fermentative, sulfate-reducing, and denitrifying bacteria from the paddy soil could reduce DMAs(V) to DMAs(III). Twenty-two strains of anaerobic bacteria isolated from the soil showed some ability to reduce DMAs(V). Rice plants grown in hydroponic culture with DMAs(V) also showed the ability to reduce DMAs(V) to DMAs(III). Rice plants and grains grown in a flooded paddy soil contained both DMAs(V) and DMAs(III); their concentrations were higher in the spikelets with straighthead disease than those without. DMAs(III) was much more toxic to the protoplasts isolated from rice plants than DMAs(V). Taken together, the ability to reduce DMAs(V) to highly toxic DMAs(III) is common to soil anaerobes and rice plants. + + + + Chen + Chuan + C + + Jiangsu Key Laboratory for Organic Waste Utilization, Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization, College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, China. + + + + Yu + Yu + Y + + Jiangsu Key Laboratory for Organic Waste Utilization, Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization, College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, China. + + + + Wang + Yijie + Y + + Jiangsu Key Laboratory for Organic Waste Utilization, Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization, College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, China. + + + + Gao + Axiang + A + + Jiangsu Key Laboratory for Organic Waste Utilization, Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization, College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, China. + + + + Yang + Baoyun + B + + Jiangsu Key Laboratory for Organic Waste Utilization, Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization, College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, China. + + + + Tang + Zhu + Z + + Jiangsu Key Laboratory for Organic Waste Utilization, Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization, College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, China. + + + + Zhao + Fang-Jie + FJ + 0000-0002-0164-169X + + Jiangsu Key Laboratory for Organic Waste Utilization, Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization, College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, China. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + Environ Sci Technol + 0213155 + 0013-936X + + IM + + arsenic + arsenic biomethylation + dimethylarsenate + dimethylarsenite + paddy soil + rice + +
+ + + + 2022 + 12 + 9 + 13 + 44 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36490306 + 10.1021/acs.est.2c07418 + + +
+ + + 36490317 + + 2022 + 12 + 09 + +
+ + 1091-6490 + + 119 + 50 + + 2022 + Dec + 13 + + + Proceedings of the National Academy of Sciences of the United States of America + Proc Natl Acad Sci U S A + + Robert F. Curl, Jr.: Physical Chemist and Codiscoverer of Fullerenes. + + e2219056119 + + 10.1073/pnas.2219056119 + + + Brooks + Philip R + PR + + Department of Chemistry, Rice University, Houston, TX 77005. + + + + Weisman + R Bruce + RB + + Department of Chemistry, Rice University, Houston, TX 77005. + + + + Johnson + Bruce R + BR + + Department of Chemistry, Rice University, Houston, TX 77005. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + Proc Natl Acad Sci U S A + 7505876 + 0027-8424 + + IM +
+ + + + 2022 + 12 + 9 + 13 + 52 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + ppublish + + 36490317 + 10.1073/pnas.2219056119 + + +
+ + + 36490299 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Carotid and femoral bruits as cardiovascular risk indicators in a middle-aged Finnish population: A 20-year prospective study. + + e0278901 + + 10.1371/journal.pone.0278901 + + Effective treatment and prevention of cardiovascular (CV) diseases requires reliable methods of assessing individual CV event risk. Although standardized risk calculators like Systematic Coronary Risk Evaluation (SCORE) are sufficient in most instances, sometimes more specific clinical examination is needed to determine the most optimal intervention and its intensity. + To study whether carotid and femoral bruits provide prognostic information on CV events, CV mortality and all-cause mortality beyond traditional CV risk factors. + 1045 subjects (49.8% men), aged 51.3 ± 5.97 years were clinically examined in the beginning of 1990's. The subjects were followed for over 20 years and data on CV events and causes of deaths was collected. + During the follow-up period, 241 (23.1%) of the subjects died and 82 (34.6%) of the deaths were of CV origin. Carotid bruits were a significant risk factor for CV deaths only if subjects with previous CV events were included. After adjusting for age, sex, systolic blood pressure, smoking, diabetes, LDL cholesterol, coronary artery disease and stroke, carotid bruits posed a hazard ratio (HR) (95% confidence interval) of 4.15 (2.39-8.52) p<0.001 for CV deaths. After excluding subjects with previous CV events (after which n = 941) neither carotid nor femoral bruits were statistically associated with CV events or all-cause mortality. Adding carotid or femoral bruits in the baseline risk model with traditional CV risk factors did not improve C-statistic, reclassification, or discrimination of the subjects. + Carotid and femoral bruits do not provide clinically useful information in a pure primary prevention setting. Carotid bruits might be useful in evaluating the overall CV risk in a population where recurrent CV events may occur. + Copyright: © 2022 Parkkila et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Parkkila + Karri + K + https://orcid.org/0000-0003-4665-9364 + + Medical Research Center Oulu, Research Unit of Internal Medicine, Oulu University Hospital, University of Oulu, Oulu, Finland. + + + + Kiviniemi + Antti + A + https://orcid.org/0000-0002-1160-493X + + Medical Research Center Oulu, Research Unit of Internal Medicine, Oulu University Hospital, University of Oulu, Oulu, Finland. + + + + Tulppo + Mikko + M + + Department of Physiology, Research Unit of Biomedicine, Faculty of Medicine, University of Oulu, Oulu, Finland. + + + + Perkiömäki + Juha + J + + Medical Research Center Oulu, Research Unit of Internal Medicine, Oulu University Hospital, University of Oulu, Oulu, Finland. + + + + Kesäniemi + Y Antero + YA + + Medical Research Center Oulu, Research Unit of Internal Medicine, Oulu University Hospital, University of Oulu, Oulu, Finland. + + + + Ukkola + Olavi + O + https://orcid.org/0000-0001-7414-2608 + + Medical Research Center Oulu, Research Unit of Internal Medicine, Oulu University Hospital, University of Oulu, Oulu, Finland. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 04 + 06 + + + 2022 + 11 + 27 + + + 2022 + 12 + 9 + 13 + 43 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490299 + 10.1371/journal.pone.0278901 + PONE-D-22-09401 + + +
+ + + 36490308 + + 2022 + 12 + 09 + +
+ + 1750-3639 + + + 2022 + Dec + 09 + + + Brain pathology (Zurich, Switzerland) + Brain Pathol + + A 64-year-old woman with frontal lobe lesion and drug-resistant epilepsy. + + e13133 + + 10.1111/bpa.13133 + + + Jin + Xueting + X + https://orcid.org/0000-0003-3876-5298 + + Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. + + + + Abdullaev + Zied + Z + + Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. + + + + Butman + John A + JA + + Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA. + + + + Inati + Sara K + SK + + Surgical Neurology Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA. + + + + Rahman + Shareena A + SA + + Surgical Neurology Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA. + + + + Zaghloul + Kareem A + KA + + Surgical Neurology Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA. + + + + Papanicolau-Sengos + Antonios + A + + Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. + + + + Pratt + Drew W + DW + + Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. + + + + Aldape + Kenneth D + KD + + Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. + + + + Quezado + Martha M + MM + + Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. + + + + eng + + + BC011846-04 + CA + NCI NIH HHS + United States + + + + Case Reports + + + 2022 + 12 + 09 + +
+ + Switzerland + Brain Pathol + 9216781 + 1015-6305 + + IM + + DNA methylation + angiocentric glioma + epilepsy + glioma + +
+ + + + 2022 + 06 + 23 + + + 2022 + 11 + 16 + + + 2022 + 12 + 9 + 13 + 52 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36490308 + 10.1111/bpa.13133 + + + REFERENCES + + Slegers RJ, Blumcke I. Low-grade developmental and epilepsy associated brain tumors: a critical update 2020. Acta Neuropathol Commun. 2020;8(1):27. + + + Capper D, Jones DTW, Sill M, Hovestadt V, Schrimpf D, Sturm D, et al. DNA methylation-based classification of central nervous system tumours. Nature. 2018;555(7697):469-74. + + + Wang H, Zhu J, Zhu P, Luo C. Angiocentric glioma: a case report and review of the literature. J Clin Neurosci. 2021;94:179-85. + + + +
+ + + 36490302 + + 2022 + 12 + 09 + +
+ + 2473-9537 + + + 2022 + Dec + 09 + + + Blood advances + Blood Adv + + Stable and durable factor IX levels in hemophilia B patients over 3 years post etranacogene dezaparvovec gene therapy. + bloodadvances.2022008886 + 10.1182/bloodadvances.2022008886 + + Etranacogene dezaparvovec (AMT-061) is a recombinant adeno-associated virus serotype 5 (AAV5) vector containing a codon-optimized Padua variant human factor IX (FIX) transgene with a liver-specific promoter. Here we report 3-year outcomes from a Phase 2b, open-label, single-dose, single-arm, multi-center trial (NCT03489291) conducted in adults with severe or moderately severe hemophilia B (FIX ≤2%). All participants (n=3) received a single intravenous dose (2×1013 gene copies/kg) and will be followed for 5 years. The primary endpoint of FIX activity ≥5% at 6 weeks was met (mean 30.6% [min-max, 23.9%-37.8%]). Secondary endpoints included bleed frequency, FIX concentrate use, joint health, and adverse events (AEs). All participants required routine FIX prophylaxis and had neutralizing antibodies to AAV5 (mean titer at screening=39) prior to etranacogene dezaparvovec treatment. Post administration, FIX activity rose to a mean of 40.8% (min-max, 31.3%-50.2%) at year 1, sustained at year 3 (mean 36.9% [min-max, 32.3%-41.5%]). All participants discontinued FIX prophylaxis. Complete elimination of bleeds occurred in 2/3 participants. One participant required on-demand FIX replacement therapy post treatment per protocol due to elective surgeries, for 2 reported bleeding episodes, and twice for a single self-administered infusion due to an unreported reason. One participant experienced 2 mild, self-limiting AEs shortly after dosing. During the 3-year study period, there were no clinically significant elevations in liver enzymes, no requirement for steroids, no FIX inhibitor development, and no late emergent safety events in any participant. Etranacogene dezaparvovec was safe and effective in adults with hemophilia B through 3 years post-administration. ClinicalTrials.gov Identifier: NCT03489291. + Copyright © 2022 American Society of Hematology. + + + + von Drygalski + Annette + A + + University of California San Diego, San Diego, California, United States. + + + + Gomez + Esteban + E + + The Center for Inherited Blood Disorders, Orange, California, United States. + + + + Giermasz + Adam + A + + University of California, Davis, Sacramento, California, United States. + + + + Castaman + Giancarlo + G + + Center for Bleeding Disorders and Coagulation, Florence, Italy. + + + + Key + Nigel S + NS + 0000-0002-8930-4304 + + University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States. + + + + Lattimore + Susan S + SS + 0000-0001-6110-0257 + + Oregon Health & Science University, Portland, Oregon, United States. + + + + Leebeek + Frank W G + FWG + + Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands. + + + + Miesbach + Wolfgang A + WA + 0000-0002-4506-0061 + + University Hospital Frankfurt, Germany. + + + + Recht + Michael + M + 0000-0002-2805-1016 + + American Thrombosis and Hemostasis Network, United States. + + + + Gut + Robert Z + RZ + + uniQure Inc, Naples, Florida, United States. + + + + Dolmetsch + Ricardo + R + + uniQure, Lexington, Massachusetts, United States. + + + + Monahan + Paul E + PE + + CSL Behring, King of Prussia, Pennsylvania, United States. + + + + Le Quellec + Sandra + S + 0000-0002-6203-3946 + + CSL Behring (Europe), Hattersheim am Main, California, Germany. + + + + Pipe + Steven W + SW + 0000-0003-2558-2089 + + Yale University School of Medicine, United States. + + + + eng + + + ClinicalTrials.gov + + NCT03489291 + + + + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + Blood Adv + 101698425 + 2473-9529 + + IM +
+ + + + 2022 + 11 + 25 + + + 2022 + 09 + 12 + + + 2022 + 11 + 10 + + + 2022 + 12 + 9 + 13 + 44 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36490302 + 493567 + 10.1182/bloodadvances.2022008886 + + +
+ + + 36490304 + + 2022 + 12 + 09 + +
+ + 1932-6203 + + 17 + 12 + + 2022 + + + PloS one + PLoS One + + Impact of the COVID-19 Vaccination Program on case incidence, emergency department visits, and hospital admissions among children aged 5-17 Years during the Delta and Omicron Periods-United States, December 2020 to April 2022. + + e0276409 + + 10.1371/journal.pone.0276409 + + In the United States, national ecological studies suggest a positive impact of COVID-19 vaccination coverage on outcomes in adults. However, the national impact of the vaccination program on COVID-19 in children remains unknown. To determine the association of COVID-19 vaccination with U.S. case incidence, emergency department visits, and hospital admissions for pediatric populations during the Delta and Omicron periods. + We conducted an ecological analysis among children aged 5-17 and compared incidence rate ratios (RRs) of COVID-19 cases, emergency department visits, and hospital admissions by pediatric vaccine coverage, with jurisdictions in the highest vaccine coverage quartile as the reference. + RRs comparing states with lowest pediatric vaccination coverage to the highest pediatric vaccination coverage were 2.00 and 0.64 for cases, 2.96 and 1.11 for emergency department visits, and 2.76 and 1.01 for hospital admissions among all children during the Delta and Omicron periods, respectively. During the 3-week peak period of the Omicron wave, only children aged 12-15 and 16-17 years in the states with the lowest versus highest coverage, had a significantly higher rate of emergency department visits (RR = 1.39 and RR = 1.34, respectively). + COVID-19 vaccines were associated with lower case incidence, emergency department visits and hospital admissions among children during the Delta period but the association was weaker during the Omicron period. Pediatric COVID-19 vaccination should be promoted as part of a program to decrease COVID-19 impact among children; however, vaccine effectiveness may be limited when available vaccines do not match circulating viral variants. + Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. + + + + Topf + Katherine G + KG + + Booz Allen Hamilton, McLean, VA, United States of America. + + + + Sheppard + Michael + M + + CDC COVID-19 Response Team, U.S. Centers for Disease Control and Prevention, Atlanta, GA, United States of America. + + + + Marx + Grace E + GE + + CDC COVID-19 Response Team, U.S. Centers for Disease Control and Prevention, Atlanta, GA, United States of America. + + + U.S. Public Health Service Commissioned Corps, Atlanta, GA, United States of America. + + + + Wiegand + Ryan E + RE + https://orcid.org/0000-0002-9486-1850 + + CDC COVID-19 Response Team, U.S. Centers for Disease Control and Prevention, Atlanta, GA, United States of America. + + + + Link-Gelles + Ruth + R + + CDC COVID-19 Response Team, U.S. Centers for Disease Control and Prevention, Atlanta, GA, United States of America. + + + U.S. Public Health Service Commissioned Corps, Atlanta, GA, United States of America. + + + + Binder + Alison M + AM + + CDC COVID-19 Response Team, U.S. Centers for Disease Control and Prevention, Atlanta, GA, United States of America. + + + + Cool + Andrea J + AJ + + Booz Allen Hamilton, McLean, VA, United States of America. + + + + Lyons + B Casey + BC + + CDC COVID-19 Response Team, U.S. Centers for Disease Control and Prevention, Atlanta, GA, United States of America. + + + + Park + Sohyun + S + + CDC COVID-19 Response Team, U.S. Centers for Disease Control and Prevention, Atlanta, GA, United States of America. + + + + Fast + Hannah E + HE + + CDC COVID-19 Response Team, U.S. Centers for Disease Control and Prevention, Atlanta, GA, United States of America. + + + + Presnetsov + Arthur + A + + Booz Allen Hamilton, McLean, VA, United States of America. + + + + Azondekon + G Roseric + GR + https://orcid.org/0000-0001-9155-4153 + + CDC COVID-19 Response Team, U.S. Centers for Disease Control and Prevention, Atlanta, GA, United States of America. + + + + Soetebier + Karl A + KA + + CDC COVID-19 Response Team, U.S. Centers for Disease Control and Prevention, Atlanta, GA, United States of America. + + + + Adjemian + Jennifer + J + + CDC COVID-19 Response Team, U.S. Centers for Disease Control and Prevention, Atlanta, GA, United States of America. + + + U.S. Public Health Service Commissioned Corps, Atlanta, GA, United States of America. + + + + Barbour + Kamil E + KE + https://orcid.org/0000-0003-0546-6742 + + CDC COVID-19 Response Team, U.S. Centers for Disease Control and Prevention, Atlanta, GA, United States of America. + + + U.S. Public Health Service Commissioned Corps, Atlanta, GA, United States of America. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 10 + 05 + + + 2022 + 11 + 26 + + + 2022 + 12 + 9 + 13 + 44 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + epublish + + 36490304 + 10.1371/journal.pone.0276409 + PONE-D-22-27322 + + +
+ + + 36490312 + + 2022 + 12 + 09 + +
+ + 1536-0237 + + 38 + 1 + + 2023 + Jan + 01 + + + Journal of thoracic imaging + J Thorac Imaging + + Computed Tomography-derived Characterization of Pericoronary, Epicardial, and Paracardial Adipose Tissue and Its Association With Myocardial Ischemia as Assessed by Computed Fractional Flow Reserve. + + 46-53 + + 10.1097/RTI.0000000000000632 + + Increased pericoronary adipose tissue (PCAT) attenuation derived from coronary computed tomography (CT) angiography (CTA) relates to coronary inflammation and cardiac mortality. We aimed to investigate the association between CT-derived characterization of different cardiac fat compartments and myocardial ischemia as assessed by computed fractional flow reserve (FFRCT). + In all, 133 patients (median 64 y, 74% male) with coronary artery disease (CAD) underwent CTA including FFRCT measurement followed by invasive FFR assessment (FFRINVASIVE). CT attenuation and volume of PCAT were quantified around the proximal right coronary artery (RCA), left anterior descending artery (LAD), and left circumflex artery (LCX). Epicardial adipose tissue (EAT) and paracardial adipose tissue (PAT; all intrathoracic adipose tissue outside the pericardium) were quantified in noncontrast cardiac CT datasets. + Median FFRCT was 0.86 [0.79, 0.91] and median FFRINVASIVE was 0.87 [0.81, 0.93]. Subjects with the presence of myocardial ischemia (n=26) defined by an FFRCT-threshold of ≤0.75 showed significantly higher RCA PCAT attenuation than individuals without myocardial ischemia (n=107) (-75.1±10.8 vs. -81.1±10.6 HU, P=0.011). In multivariable analysis adjusted for age, body mass index, sex and risk factors, increased RCA PCAT attenuation remained a significant predictor of myocardial ischemia. Between individuals with myocardial ischemia compared with individuals without myocardial ischemia, there was no significant difference in the volume and CT attenuation of EAT and PAT or in the PCAT volume of RCA, LAD, and LCX. + Increased RCA PCAT attenuation is associated with the presence of myocardial ischemia as assessed by FFR, while PCAT volume, EAT, and PAT are not. + Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved. + + + + Duncker + Hendrik + H + + Department of Cardiology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany. + + + + Achenbach + Stephan + S + + Department of Cardiology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany. + + + + Moshage + Maximilian + M + + Department of Cardiology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany. + + + + Dey + Damini + D + + Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA. + + + + Bittner + Daniel O + DO + + Department of Cardiology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany. + + + + Ammon + Fabian + F + + Department of Cardiology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany. + + + + Marwan + Mohamed + M + + Department of Cardiology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany. + + + + Goeller + Markus + M + + Department of Cardiology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany. + + + + eng + + Journal Article + + + 2021 + 12 + 16 + +
+ + United States + J Thorac Imaging + 8606160 + 0883-5993 + + IM + The authors declare no conflicts of interest. +
+ + + + 2022 + 12 + 9 + 13 + 52 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + ppublish + + 36490312 + 10.1097/RTI.0000000000000632 + 00005382-202301000-00010 + + + + Ross R. Atherosclerosis—an inflammatory disease. N Engl J Med. 1999;340:115–126. + + + Bäck M, Yurdagul A, Tabas I, et al. Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities. Nat Rev Cardiol. 2019;16:389–406. + + + Goeller M, Achenbach S, Cadet S, et al. Pericoronary adipose tissue computed tomography attenuation and high-risk plaque characteristics in acute coronary syndrome compared with stable coronary artery disease. JAMA Cardiol. 2018;3:858–863. + + + Antonopoulos AS, Sanna F, Sabharwal N, et al. Detecting human coronary inflammation by imaging perivascular fat. Sci Transl Med. 2017;9:398. + + + Oikonomou EK, Marwan M, Desai MY, et al. Non-invasive detection of coronary inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP CT study): a post-hoc analysis of prospective outcome data. Lancet. 2018;392:929–939. + + + Goeller M, Tamarappoo BK, Kwan AC, et al. Relationship between changes in pericoronary adipose tissue attenuation and coronary plaque burden quantified from coronary computed tomography angiography. Eur Heart J Cardiovasc Imaging. 2019;20:636–643. + + + Antoniades C, Kotanidis CP, Berman DS. State-of-the-art review article. Atherosclerosis affecting fat: what can we learn by imaging perivascular adipose tissue? J Cardiovasc Comput Tomogr. 2019;13:288–296. + + + Marwan M, Achenbach S. Quantification of epicardial fat by computed tomography: why, when and how? J Cardiovasc Comput Tomogr. 2013;7:3–10. + + + Goeller M, Achenbach S, Marwan M, et al. Epicardial adipose tissue density and volume are related to subclinical atherosclerosis, inflammation and major adverse cardiac events in asymptomatic subjects. J Cardiovasc Comput Tomogr. 2018;12:67–73. + + + Konishi M, Sugiyama S, Sato Y, et al. Pericardial fat inflammation correlates with coronary artery disease. Atherosclerosis. 2010;213:649–655. + + + Nomura CH, Assuncao-Jr AN, Guimarães PO, et al. Association between perivascular inflammation and downstream myocardial perfusion in patients with suspected coronary artery disease. Eur Heart J Cardiovasc Imaging. 2020;21:599–605. + + + Hoshino M, Yang S, Sugiyama T, et al. Peri-coronary inflammation is associated with findings on coronary computed tomography angiography and fractional flow reserve. J Cardiovasc Comput Tomogr. 2020;14:483–489. + + + Yu M, Dai X, Deng J, et al. Diagnostic performance of perivascular fat attenuation index to predict hemodynamic significance of coronary stenosis: a preliminary coronary computed tomography angiography study. Eur Radiol. 2020;30:673–681. + + + Hell MM, Ding X, Rubeaux M, et al. Epicardial adipose tissue volume but not density is an independent predictor for myocardial ischemia. J Cardiovasc Comput Tomogr. 2016;10:141–149. + + + Du Y, Yang L, Liu Y, et al. Relation between quantity and quality of peri-coronary epicardial adipose tissue and its underlying hemodynamically significant coronary stenosis. BMC Cardiovasc Disord. 2020;20:226. + + + Janik M, Hartlage G, Alexopoulos N, et al. Epicardial adipose tissue volume and coronary artery calcium to predict myocardial ischemia on positron emission tomography-computed tomography studies. J Nucl Cardiol. 2010;17:841–847. + + + Otaki Y, Hell M, Slomka PJ, et al. Relationship of epicardial fat volume from noncontrast CT with impaired myocardial flow reserve by positron emission tomography. J Cardiovasc Comput Tomogr. 2015;9:303–309. + + + Romijn MA, Danad I, Bakkum MJ, et al. Incremental diagnostic value of epicardial adipose tissue for the detection of functionally relevant coronary artery disease. Atherosclerosis. 2015;242:161–166. + + + Mancio J, Azevedo D, Saraiva F, et al. Epicardial adipose tissue volume assessed by computed tomography and coronary artery disease: a systematic review and meta-analysis. Eur Heart J Cardiovasc Imaging. 2018;19:490–497. + + + Abbara S, Blanke P, Maroules CD, et al. SCCT guidelines for the performance and acquisition of coronary computed tomographic angiography: a report of the society of Cardiovascular Computed Tomography Guidelines Committee: Endorsed by the North American Society for Cardiovascular Imaging (NASCI). J Cardiovasc Comput Tomogr. 2016;10:435–449. + + + Agatston AS, Janowitz WR, Hildner FJ, et al. Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol. 1990;15:827–832. + + + Röther J, Moshage M, Dey D, et al. Comparison of invasively measured FFR with FFR derived from coronary CT angiography for detection of lesion-specific ischemia: results from a PC-based prototype algorithm. J Cardiovasc Comput Tomogr. 2018;12:101–107. + + + Itu L, Rapaka S, Passerini T, et al. A machine-learning approach for computation of fractional flow reserve from coronary computed tomography. J Appl Physiol (1985). 2016;121:42–52. + + + Schlundt C, Bietau C, Klinghammer L, et al. Comparison of intracoronary versus intravenous administration of adenosine for measurement of coronary fractional flow reserve. Circ Cardiovasc Interv. 2015;8:5. + + + Dey D, Nakazato R, Slomka PJ, et al. CT quantification of epicardial fat: implications for cardiovascular risk assessment. Curr Cardiovasc Imaging Rep. 2012;5:352–359. + + + Commandeur F, Goeller M, Betancur J, et al. Deep learning for quantification of epicardial and thoracic adipose tissue from non-contrast CT. IEEE Trans Med Imaging. 2018;37:1835–1846. + + + Tanami Y, Jinzaki M, Kishi S, et al. Lack of association between epicardial fat volume and extent of coronary artery calcification, severity of coronary artery disease, or presence of myocardial perfusion abnormalities in a diverse, symptomatic patient population: results from the CORE320 multicenter study. Circ Cardiovasc Imaging. 2015;8:e002676. + + + Tamarappoo B, Dey D, Shmilovich H, et al. Increased pericardial fat volume measured from noncontrast CT predicts myocardial ischemia by SPECT. JACC Cardiovasc Imaging. 2010;3:1104–1112. + + + Balcer B, Dykun I, Schlosser T, et al. Pericoronary fat volume but not attenuation differentiates culprit lesions in patients with myocardial infarction. Atherosclerosis. 2018;276:182–188. + + + Goeller M, Achenbach S, Duncker H, et al. State-of-the-art review article imaging of the pericoronary adipose tissue (PCAT) using cardiac computed tomography: modern clinical implications. J Thoracic Imaging. 2021;36:149–161. + + + Nørgaard BL, Hjort J, Gaur S, et al. Clinical use of coronary CTA-derived FFR for decision-making in stable CAD. JACC Cardiovasc Imaging. 2017;10:541–550. + + + Mancio J, Oikonomou EK, Antoniades C. Perivascular adipose tissue and coronary atherosclerosis. Heart. 2018;104:1654–1662. + + + McKenney-Drake ML, Rodenbeck SD, Bruning RS, et al. Epicardial adipose tissue removal potentiates outward remodeling and arrests coronary atherogenesis. Ann Thorac Surg. 2017;103:1622–1630. + + + Gil-Ortega M, Somoza B, Huang Y, et al. Regional differences in perivascular adipose tissue impacting vascular homeostasis. Trends Endocrinol Metab. 2015;26:367–375. + + + Lavi S, McConnell JP, Rihal CS, et al. Local production of lipoprotein-associated phospholipase A2 and lysophosphatidylcholine in the coronary circulation: association with early coronary atherosclerosis and endothelial dysfunction in humans. Circulation. 2007;115:2715–2721. + + + Dey D, Diaz Zamudio M, Schuhbaeck A, et al. Relationship between quantitative adverse plaque features from coronary computed tomography angiography and downstream impaired myocardial flow reserve by 13N-ammonia positron emission tomography: a pilot study. Circ Cardiovasc Imaging. 2015;8:e003255. doi: 10.1161/CIRCIMAGING.115.003255. + + 10.1161/CIRCIMAGING.115.003255 + + + + Ohyama K, Matsumoto Y, Takanami K, et al. Coronary adventitial and perivascular adipose tissue inflammation in patients with vasospastic angina. J Am Coll Cardiol. 2018;71:414–425. + + + +
+ + + 36490309 + + 2022 + 12 + 09 + +
+ + 1945-4589 + + 14 + + 2022 + Dec + 09 + + + Aging + Aging (Albany NY) + + Circulating levels of MOTS-c in patients with breast cancer treated with metformin. + 10.18632/aging.204423 + + The mitokine MOTS-c is a mitochondrially-encoded "exercise-mimetic peptide" expressed in multiple tissues, particularly skeletal muscles, which can be detected as a circulating hormone in the blood. MOTS-c mechanisms of action (MoA) involve insulin sensitization, enhanced glucose utilization, suppression of mitochondrial respiration, and targeting of the folate-AICAR-AMPK pathway. Although MOTS-c MoA largely overlap those of the anti-diabetic biguanide metformin, the putative regulatory actions of metformin on MOTS-c have not yet been evaluated in detail. Here, we measured circulating MOTS-c in paired baseline and post-treatment sera obtained from HER2-positive breast cancer patients randomized to receive either metformin combined with neoadjuvant chemotherapy and trastuzumab or an equivalent regimen without metformin. We failed to find any significant alteration of circulating MOTS-c -as measured using the commercially available competitive ELISA CEX132Hu- in response to 24 weeks of a neoadjuvant chemotherapy/trastuzumab regimen with or without daily metformin. Changes in circulating MOTS-c levels failed to reach statistical significance when comparing patients achieving pathological complete response (pCR), irrespective of metformin treatment. The inability of metformin to target skeletal muscle, the major tissue for MOTS-c production and secretion, might limit its regulatory effects on circulating MOTS-c. Further studies are needed to definitely elucidate the nature of the interaction between metformin and MOTS-c in cancer and non-cancer patients. + + + + Cuyàs + Elisabet + E + + Metabolism and Cancer Group, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology, Girona 17005, Spain. + + + Girona Biomedical Research Institute, Girona 17190, Spain. + + + + Verdura + Sara + S + + Metabolism and Cancer Group, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology, Girona 17005, Spain. + + + Girona Biomedical Research Institute, Girona 17190, Spain. + + + + Martin-Castillo + Begoña + B + + Girona Biomedical Research Institute, Girona 17190, Spain. + + + Clinical Research Unit, Catalan Institute of Oncology, Girona 17005, Spain. + + + + Menendez + Javier A + JA + + Metabolism and Cancer Group, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology, Girona 17005, Spain. + + + Girona Biomedical Research Institute, Girona 17190, Spain. + + + + METTEN study group + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + Aging (Albany NY) + 101508617 + 1945-4589 + + IM + + MOTS-c + breast cancer + metformin + +
+ + + + 2022 + 10 + 08 + + + 2022 + 11 + 19 + + + 2022 + 12 + 9 + 13 + 52 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36490309 + 204423 + 10.18632/aging.204423 + + +
+ + + 36490311 + + 2022 + 12 + 09 + +
+ + 1536-0237 + + 38 + 1 + + 2023 + Jan + 01 + + + Journal of thoracic imaging + J Thorac Imaging + + Coronary Artery Calcium Evaluation Using New Generation Photon-counting Computed Tomography Yields Lower Radiation Dose Compared With Standard Computed Tomography. + + 44-45 + + 10.1097/RTI.0000000000000685 + + Prospective head-to-head comparison of coronary calcium scores between standard computed tomography (CT) and photon-counting CT show no significant differences, while photon-counting CT administers substantially lower radiation dose. + Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved. + + + + Schwartz + Fides R + FR + + Departments of Radiology. + + + + Daubert + Melissa A + MA + + Cardiology, Duke University Health System, Durham, NC. + + + + Molvin + Lior + L + + Departments of Radiology. + + + + Ramirez-Giraldo + Juan C + JC + + Research and Development, Siemens Healthineers, Malvern, PA. + + + + Samei + Ehsan + E + + Departments of Radiology. + + + + Marin + Daniele + D + + Departments of Radiology. + + + + Tailor + Tina D + TD + + Departments of Radiology. + + + + eng + + Journal Article + + + 2022 + 10 + 17 + +
+ + United States + J Thorac Imaging + 8606160 + 0883-5993 + + IM + J.C.R.-G. is an employee of Siemens Healthineers. The remaining authors declare no conflicts of interest. +
+ + + + 2022 + 12 + 9 + 13 + 52 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + ppublish + + 36490311 + 10.1097/RTI.0000000000000685 + 00005382-202301000-00009 + + + + Pletcher MJ, Tice JA, Pignone M, et al. Using the coronary artery calcium score to predict coronary heart disease events: a systematic review and meta-analysis. Arch Intern Med. 2004;164:1285–1292. + + + McCollough CH, Leng S, Yu L, et al. Dual- and multi-energy CT: principles, technical approaches, and clinical applications. Radiology. 2015;276:637–653. + + + Flohr T, Petersilka M, Henning A, et al. Photon-counting CT review. Phys Med. 2020;79:126–136. + + + Willemink MJ, Persson M, Pourmorteza A, et al. Photon-counting CT: technical principles and clinical prospects. Radiology. 2018;289:293–312. + + + Agatston AS, Janowitz WR, Hildner FJ, et al. Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol. 1990;15:827–832. + + + Willemink MJ, Vliegenthart R, Takx RAP, et al. Coronary artery calcification scoring with state-of-the-art CT scanners from different vendors has substantial effect on risk classification. Radiology. 2014;273:695–702. + + + Symons R, Sandfort V, Mallek M, et al. Coronary artery calcium scoring with photon-counting CT: first in vivo human experience. Int J Cardiovasc Imaging. 2019;35:733–739. + + + +
+ + + 36490313 + + 2022 + 12 + 09 + +
+ + 2373-9878 + + + 2022 + Dec + 09 + + + ACS biomaterials science & engineering + ACS Biomater Sci Eng + + Synthesis and Characterization of a Biocompatible Nanoplatform Based on Silica-Embedded SPIONs Functionalized with Polydopamine. + 10.1021/acsbiomaterials.2c00946 + + Superparamagnetic iron oxide nanoparticles (SPIONs) have gained increasing interest in nanomedicine, but most of those that have entered the clinical trials have been withdrawn due to toxicity concerns. Therefore, there is an urgent need to design low-risk and biocompatible SPION formulations. In this work, we present an original safe-by-design nanoplatform made of silica nanoparticles loaded with SPIONs and decorated with polydopamine (SPIONs@SiO2-PDA) and the study of its biocompatibility performance by an ad hoc thorough in vitro to in vivo nanotoxicological methodology. The results indicate that the SPIONs@SiO2-PDA have excellent colloidal stability in serum-supplemented culture media, even after long-term (24 h) exposure, showing no cytotoxic or genotoxic effects in vitro and ex vivo. Physiological responses, evaluated in vivo using Caenorhabditis elegans as the animal model, showed no impact on fertility and embryonic viability, induction of an oxidative stress response, and a mild impact on animal locomotion. These tests indicate that the synergistic combination of the silica matrix and PDA coating we developed effectively protects the SPIONs, providing enhanced colloidal stability and excellent biocompatibility. + + + + Romano + Miriam + M + 0000-0002-3972-460X + + Department of Molecular and Translational Medicine, University of Brescia, Brescia25123, Italy. + + + Center for Colloid and Surface Science (CSGI), Florence50019, Italy. + + + Joint Mass Spectrometry Center (JMSC) at Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg85764, Germany. + + + + González Gómez + Manuel Antonio + MA + + NANOMAG Laboratory, Applied Physics Department, iMATUS Materials Institute, Universidade de Santiago de Compostela, Santiago de Compostela15782, Spain. + + + + Santonicola + Pamela + P + 0000-0002-4094-9996 + + Institute of Biosciences and BioResources (IBBR), National Research Council of Italy (CNR), Naples80131, Italy. + + + + Aloi + Noemi + N + 0000-0002-6424-8588 + + Institute for Biomedical Research and Innovation (IRIB), National Research Council of Italy (CNR), Palermo90146, Italy. + + + + Offer + Svenja + S + + Joint Mass Spectrometry Center (JMSC) at Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg85764, Germany. + + + + Pantzke + Jana + J + + Joint Mass Spectrometry Center (JMSC) at Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg85764, Germany. + + + + Raccosta + Samuele + S + + Institute of Biophysics (IBF), National Research Council of Italy (CNR), Palermo90146, Italy. + + + + Longo + Valeria + V + + Institute for Biomedical Research and Innovation (IRIB), National Research Council of Italy (CNR), Palermo90146, Italy. + + + + Surpi + Alessandro + A + + Institute of Nanostructured Materials (ISMN), National Research Council of Italy (CNR), Bologna40129, Italy. + + + + Alacqua + Silvia + S + + Department of Molecular and Translational Medicine, University of Brescia, Brescia25123, Italy. + + + Center for Colloid and Surface Science (CSGI), Florence50019, Italy. + + + Joint Mass Spectrometry Center (JMSC) at Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg85764, Germany. + + + + Zampi + Giuseppina + G + + Institute of Biosciences and BioResources (IBBR), National Research Council of Italy (CNR), Naples80131, Italy. + + + + Dediu + Valentin Alek + VA + + Institute of Nanostructured Materials (ISMN), National Research Council of Italy (CNR), Bologna40129, Italy. + + + + Michalke + Bernhard + B + + Research Unit Analytical BioGeoChemistry, Helmholtz Zentrum München, Neuherberg85764, Germany. + + + + Zimmerman + Ralf + R + + Joint Mass Spectrometry Center (JMSC) at Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg85764, Germany. + + + + Manno + Mauro + M + 0000-0001-9843-0428 + + Institute of Biophysics (IBF), National Research Council of Italy (CNR), Palermo90146, Italy. + + + + Piñeiro + Yolanda + Y + 0000-0003-4614-1629 + + NANOMAG Laboratory, Applied Physics Department, iMATUS Materials Institute, Universidade de Santiago de Compostela, Santiago de Compostela15782, Spain. + + + + Colombo + Paolo + P + + Institute for Biomedical Research and Innovation (IRIB), National Research Council of Italy (CNR), Palermo90146, Italy. + + + + Di Schiavi + Elia + E + + Institute of Biosciences and BioResources (IBBR), National Research Council of Italy (CNR), Naples80131, Italy. + + + + Rivas + José + J + 0000-0002-5059-3196 + + NANOMAG Laboratory, Applied Physics Department, iMATUS Materials Institute, Universidade de Santiago de Compostela, Santiago de Compostela15782, Spain. + + + + Bergese + Paolo + P + 0000-0002-4652-2168 + + Department of Molecular and Translational Medicine, University of Brescia, Brescia25123, Italy. + + + Center for Colloid and Surface Science (CSGI), Florence50019, Italy. + + + + Di Bucchianico + Sebastiano + S + 0000-0002-6396-892X + + Joint Mass Spectrometry Center (JMSC) at Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg85764, Germany. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + ACS Biomater Sci Eng + 101654670 + 2373-9878 + + IM + + C. elegans + SPION + coating materials + nanotoxicity + polydopamine + silica + +
+ + + + 2022 + 12 + 9 + 13 + 52 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36490313 + 10.1021/acsbiomaterials.2c00946 + + +
+ + + 36490314 + + 2022 + 12 + 09 + +
+ + 1091-6490 + + 119 + 50 + + 2022 + Dec + 13 + + + Proceedings of the National Academy of Sciences of the United States of America + Proc Natl Acad Sci U S A + + Ecology, evolution, and conservation of Ethiopia's biodiversity. + + e2206635119 + + 10.1073/pnas.2206635119 + + Ethiopia is home to one of the richest and most unique assemblages of fauna and flora on the African continent. Contained within its borders are two major centers of endemism, the mesic Roof of Africa (also known as the Ethiopian Highlands) and the arid Horn of Africa, resulting from the country's varied topography and consequent geographic isolation. These centers of endemism are crucial to global conservation as evidenced by their classification within the Eastern Afromontane and Horn of Africa biodiversity hotspots, respectively. Ethiopia's diverse ecosystems and the biodiversity they contain are increasingly threatened by climate change and the growing impacts of Africa's second largest human and largest livestock populations. In this paper, we focus on several key areas of recent and ongoing research on Ethiopian biodiversity that have broadened our understanding of nature and its conservation in Africa. Topics explored include the behavioral ecology of Ethiopia's large social mammals, the ecology and conservation of its unique coffee forests, and Ethiopian approaches to community conservation, fortress conservation, and nature-based solutions. We also highlight the increasing prominence of Ethiopian scientists in studies of the country's biodiversity in recent decades. We suggest promising avenues for future research in evolutionary biology, ecology, systematics, and conservation in Ethiopia and discuss how recent and ongoing work in Ethiopia is helping us better understand and conserve nature in the human-dominated landscapes of Africa and other tropical regions today. + + + + Fashing + Peter J + PJ + 0000-0003-3854-1999 + + Division of Anthropology & Environmental Studies Program, California State University Fullerton, Fullerton, CA 92834. + + + Centre for Ecological and Evolutionary Synthesis, Department of Biosciences, University of Oslo, Oslo 0371, Norway. + + + + Nguyen + Nga + N + + Division of Anthropology & Environmental Studies Program, California State University Fullerton, Fullerton, CA 92834. + + + Centre for Ecological and Evolutionary Synthesis, Department of Biosciences, University of Oslo, Oslo 0371, Norway. + + + + Demissew + Sebsebe + S + 0000-0002-0123-9596 + + Department of Plant Biology & Biodiversity Management, College of Natural Sciences, Addis Ababa University, Addis Ababa 1176, Ethiopia. + + + + Gizaw + Abel + A + 0000-0002-2045-1285 + + Department of Plant Biology & Biodiversity Management, College of Natural Sciences, Addis Ababa University, Addis Ababa 1176, Ethiopia. + + + Natural History Museum, University of Oslo, Oslo 0318, Norway. + + + + Atickem + Anagaw + A + 0000-0002-2397-6108 + + Department of Zoological Sciences, Addis Ababa University, Addis Ababa, Ethiopia. + + + + Mekonnen + Addisu + A + + Department of Anthropology and Archaeology, University of Calgary, Calgary, AB T2N 1NF Canada. + + + Department of Wildlife and Ecotourism Management, Bahir Dar University, Bahir Dar 79, Ethiopia. + + + + Nurmi + Niina O + NO + 0000-0003-2036-3346 + + University of Eastern Finland Library, University of Eastern Finland, Joensuu 80101, Finland. + + + + Kerby + Jeffrey T + JT + 0000-0002-2739-9096 + + Aarhus Institute of Advanced Studies, Aarhus University, Aarhus 8000, Denmark. + + + Section for Ecoinformatics and Biodiversity, Department of Biology, Aarhus University, Aarhus 8000, Denmark. + + + + Stenseth + Nils Chr + NC + 0000-0002-1591-5399 + + Centre for Ecological and Evolutionary Synthesis, Department of Biosciences, University of Oslo, Oslo 0371, Norway. + + + Department of Zoological Sciences, Addis Ababa University, Addis Ababa, Ethiopia. + + + + eng + + + None + Fulbright Norway (US-Norway Fulbright) + + + + None + San Diego Zoo Institute for Conservation Research (SDZICR) + + + + None + Carlsbergfondet (Carlsberg Foundation) + + + + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + Proc Natl Acad Sci U S A + 7505876 + 0027-8424 + + IM + + biodiversity hotspots + climate change + community conservation + +
+ + + + 2022 + 12 + 9 + 13 + 52 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + ppublish + + 36490314 + 10.1073/pnas.2206635119 + + +
+ + + 36490305 + + 2022 + 12 + 09 + +
+ + 1549-9626 + + + 2022 + Dec + 09 + + + Journal of chemical theory and computation + J Chem Theory Comput + + Interexcited State Photophysics I: Benchmarking Density Functionals for Computing Nonadiabatic Couplings and Internal Conversion Rate Constants. + 10.1021/acs.jctc.2c00888 + + We present the first benchmarking study of nonadiabatic matrix coupling elements (NACMEs) calculated using different density functionals. Using the S1S0 transition in perylene solvated in toluene as a case study, we calculate the photophysical properties and corresponding rate constants for a variety of density functionals from each rung of Jacob's ladder. The singlet photoluminescence quantum yield (sPLQY) is taken as a measure of accuracy, measured experimentally here as 0.955. Important quantum chemical parameters such as geometries, absorption, emission, and adiabatic energies, NACMEs, Hessians, and transition dipole moments were calculated for each density functional basis set combination (data set) using density functional theory based multireference configuration interaction (DFT/MRCI) and compared to experiment where possible. We were able to derive simple relations between the TDDFT and DFT/MRCI photophysical properties; with semiempirical damping factors of ∼0.843 ± 0.017 and ∼0.954 ± 0.064 for TDDFT transition dipole moments and energies to DFT/MRCI level approximations, respectively. NACMEs were dominated by out-of-plane derivative components belonging to the center-most ring atoms with weaker contributions from perturbations along the transverse and longitudinal axes. Calculated theoretical spectra compared well to both experiment and literature, with fluorescence lifetimes between 7.1 and 12.5 ns, agreeing within a factor of 2 with experiment. Internal conversion (IC) rates were then calculated and were found to vary wildly between 106-1016 s-1 compared with an experimental rate of the order 107 s-1. Following further testing by mixing data sets, we found a strong dependence on the method used to obtain the Hessian. The 5 characterized data sets ranked in order of most promising are PBE0/def2-TZVP, ωB97XD/def2-TZVP, HCTH407/TZVP, PBE/TZVP, and PBE/def2-TZVP. + + + + Manian + Anjay + A + 0000-0002-6184-275X + + ARC Centre of Excellence in Exciton Science, School of Science, RMIT University, Melbourne3000, Australia. + + + + Hudson + Rohan J + RJ + 0000-0001-7000-2253 + + ARC Centre of Excellence in Exciton Science, School of Chemistry, University of Melbourne, Parkville3010, Australia. + + + + Ramkissoon + Pria + P + 0000-0002-5001-8917 + + ARC Centre of Excellence in Exciton Science, School of Chemistry, University of Melbourne, Parkville3010, Australia. + + + + Smith + Trevor A + TA + 0000-0003-4453-9713 + + ARC Centre of Excellence in Exciton Science, School of Chemistry, University of Melbourne, Parkville3010, Australia. + + + + Russo + Salvy P + SP + 0000-0003-3589-3040 + + ARC Centre of Excellence in Exciton Science, School of Science, RMIT University, Melbourne3000, Australia. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + J Chem Theory Comput + 101232704 + 1549-9618 + + IM +
+ + + + 2022 + 12 + 9 + 13 + 44 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36490305 + 10.1021/acs.jctc.2c00888 + + +
+ + + 36490310 + + 2022 + 12 + 09 + +
+ + 1536-0237 + + 38 + 1 + + 2023 + Jan + 01 + + + Journal of thoracic imaging + J Thorac Imaging + + Editors' Recognition for Reviewing in 2022. + + 3 + + 10.1097/RTI.0000000000000686 + + + Schoepf + U Joseph + UJ + + + Kanne + Jeffrey P + JP + + + Shaham + Dorith + D + + + eng + + Journal Article + + + 2021 + 12 + 21 + +
+ + United States + J Thorac Imaging + 8606160 + 0883-5993 + + IM + The authors declare no conflicts of interest. +
+ + + + 2022 + 12 + 9 + 13 + 52 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + ppublish + + 36490310 + 10.1097/RTI.0000000000000686 + 00005382-202301000-00002 + + +
+ + + 36490315 + + 2022 + 12 + 09 + +
+ + 1091-6490 + + 119 + 50 + + 2022 + Dec + 13 + + + Proceedings of the National Academy of Sciences of the United States of America + Proc Natl Acad Sci U S A + + The BRCA1 BRCT promotes antisense RNA production and double-stranded RNA formation to suppress ribosomal R-loops. + + e2217542119 + + 10.1073/pnas.2217542119 + + R-loops, or RNA:DNA hybrids, can induce DNA damage, which requires DNA repair factors including breast cancer type 1 susceptibility protein (BRCA1) to restore genomic integrity. To date, several pathogenic mutations have been found within the tandem BRCA1 carboxyl-terminal (BRCT) domains that mediate BRCA1 interactions with proteins and DNA in response to DNA damage. Here, we describe a nonrepair role of BRCA1 BRCT in suppressing ribosomal R-loops via two mechanisms. Through its RNA binding and annealing activities, BRCA1 BRCT facilitates the formation of double-stranded RNA between ribosomal RNA (rRNA) and antisense-rRNA (as-rRNA), hereby minimizing rRNA hybridization to ribosomal DNA to form R-loops. BRCA1 BRCT also promotes RNA polymerase I-dependent transcription of as-rRNA to enhance double-stranded rRNA (ds-rRNA) formation. In addition, BRCA1 BRCT-mediated as-rRNA production restricts rRNA maturation in unperturbed cells. Hence, impairing as-rRNA transcription and ds-rRNA formation due to BRCA1 BRCT deficiency deregulates rRNA processing and increases ribosomal R-loops and DNA breaks. Our results link ribosomal biogenesis dysfunction to BRCA1-associated genomic instability. + + + + Chang + Chou-Wei + CW + + Vesign Therapeutics, Cambridge, MA 02139. + + + + Singh + Anup Kumar + AK + + Department of Cancer Genetics and Epigenetics, Beckman Research Institute of City of Hope, Duarte, CA 91010-3000. + + + + Li + Min + M + + Department of Cancer Genetics and Epigenetics, Beckman Research Institute of City of Hope, Duarte, CA 91010-3000. + + + + Guan + Li + L + + Department of Radiation Oncology, Stanford University, Stanford, CA 94305. + + + + Le + Nhung + N + + Department of Cancer Genetics and Epigenetics, Beckman Research Institute of City of Hope, Duarte, CA 91010-3000. + + + + Omabe + Kenneth + K + + Department of Cancer Genetics and Epigenetics, Beckman Research Institute of City of Hope, Duarte, CA 91010-3000. + + + + Liang + Feng + F + + Neuroscience Graduate Program, University of Southern California, Los Angeles, CA 90089. + + + + Liu + Yilun + Y + 0000-0001-6884-8487 + + Department of Cancer Genetics and Epigenetics, Beckman Research Institute of City of Hope, Duarte, CA 91010-3000. + + + + eng + + + R01 GM127602 + GM + NIGMS NIH HHS + United States + + + R01 CA225842 + HHS | NIH | National Cancer Institute (NCI) + + + + R01 CA130899 + CA + NCI NIH HHS + United States + + + T32CA186895 + HHS | NIH | National Cancer Institute (NCI) + + + + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + Proc Natl Acad Sci U S A + 7505876 + 0027-8424 + + IM + + BRCA1 + R-loops + antisense RNA + ribosomal RNA + +
+ + + + 2022 + 12 + 9 + 13 + 52 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + ppublish + + 36490315 + 10.1073/pnas.2217542119 + + +
+ + + 36490316 + + 2022 + 12 + 09 + +
+ + 1091-6490 + + 119 + 50 + + 2022 + Dec + 13 + + + Proceedings of the National Academy of Sciences of the United States of America + Proc Natl Acad Sci U S A + + SOBA: Development and testing of a soluble oligomer binding assay for detection of amyloidogenic toxic oligomers. + + e2213157119 + + 10.1073/pnas.2213157119 + + The formation of toxic Amyloid β-peptide (Aβ) oligomers is one of the earliest events in the molecular pathology of Alzheimer's Disease (AD). These oligomers lead to a variety of downstream effects, including impaired neuronal signaling, neuroinflammation, tau phosphorylation, and neurodegeneration, and it is estimated that these events begin 10 to 20 y before the presentation of symptoms. Toxic Aβ oligomers contain a nonstandard protein structure, termed α-sheet, and designed α-sheet peptides target this main-chain structure in toxic oligomers independent of sequence. Here we show that a designed α-sheet peptide inhibits the deleterious effects on neuronal signaling and also serves as a capture agent in our soluble oligomer binding assay (SOBA). Pre-incubated synthetic α-sheet-containing Aβ oligomers produce strong SOBA signals, while monomeric and β-sheet protofibrillar Aβ do not. α-sheet containing oligomers were also present in cerebrospinal fluid (CSF) from an AD patient versus a noncognitively impaired control. For the detection of toxic oligomers in plasma, we developed a plate coating to increase the density of the capture peptide. The proof of concept was achieved by testing 379 banked human plasma samples. SOBA detected Aβ oligomers in patients on the AD continuum, including controls who later progressed to mild cognitive impairment. In addition, SOBA discriminated AD from other forms of dementia, yielding sensitivity and specificity of 99% relative to clinical and neuropathological diagnoses. To explore the broader potential of SOBA, we adapted the assay for a-synuclein oligomers and confirmed their presence in CSF from patients with Parkinson's disease and Lewy body dementia. + + + + Shea + Dylan + D + + Molecular Engineering Program, University of Washington, Seattle, WA 98105. + + + Department of Bioengineering, University of Washington, Seattle, WA 98105. + + + + Colasurdo + Elizabeth + E + 0000-0002-3259-0098 + + Veterans Affairs Northwest Network Mental Illness Research, Education, and Clinical Center, Veteran Affairs Puget Sound Health Care System, Seattle, WA 98108. + + + + Smith + Alec + A + 0000-0002-0001-8484 + + Department of Physiology and Biophysics, University of Washington, Seattle, 98105. + + + + Paschall + Courtnie + C + 0000-0001-7614-9408 + + Department of Bioengineering, University of Washington, Seattle, WA 98105. + + + Department of Neurosurgery, University of Washington, Seattle, WA 98195. + + + + Jayadev + Suman + S + + Department of Neurology, University of Washington, Seattle, WA 98195. + + + + Keene + C Dirk + CD + 0000-0002-5291-1469 + + Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195. + + + + Galasko + Douglas + D + + Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093. + + + + Ko + Andrew + A + 0000-0002-6253-9891 + + Department of Neurosurgery, University of Washington, Seattle, WA 98195. + + + + Li + Ge + G + 0000-0001-7780-2042 + + Mental Illness Research, Education and Clinical Center Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108. + + + Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108. + + + Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195. + + + + Peskind + Elaine + E + + Veterans Affairs Northwest Network Mental Illness Research, Education, and Clinical Center, Veteran Affairs Puget Sound Health Care System, Seattle, WA 98108. + + + Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195. + + + + Daggett + Valerie + V + + Molecular Engineering Program, University of Washington, Seattle, WA 98105. + + + Department of Bioengineering, University of Washington, Seattle, WA 98105. + + + + eng + + + R01AG067476 + HHS | NIH | National Institute on Aging (NIA) + + + + P0105136 + HHS | NIH | National Institute on Aging (NIA) + + + + 532EB1650 + HHS | NIH | National Institute of Biomedical Imaging and Bioengineering (NIBIB) + + + + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + Proc Natl Acad Sci U S A + 7505876 + 0027-8424 + + IM + + Alzheimer’s disease + SOBA + alpha-sheet + detection + toxic oligomer + +
+ + + + 2022 + 12 + 9 + 13 + 52 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + ppublish + + 36490316 + 10.1073/pnas.2213157119 + + +
+ + + 36490318 + + 2022 + 12 + 09 + +
+ + 1091-6490 + + 119 + 50 + + 2022 + Dec + 13 + + + Proceedings of the National Academy of Sciences of the United States of America + Proc Natl Acad Sci U S A + + MipZ caps the plus-end of FtsZ polymers to promote their rapid disassembly. + + e2208227119 + + 10.1073/pnas.2208227119 + + The spatiotemporal regulation of cell division is a fundamental issue in cell biology. Bacteria have evolved a variety of different systems to achieve proper division site placement. In many cases, the underlying molecular mechanisms are still incompletely understood. In this study, we investigate the function of the cell division regulator MipZ from Caulobacter crescentus, a P-loop ATPase that inhibits the polymerization of the treadmilling tubulin homolog FtsZ near the cell poles, thereby limiting the assembly of the cytokinetic Z ring to the midcell region. We show that MipZ interacts with FtsZ in both its monomeric and polymeric forms and induces the disassembly of FtsZ polymers in a manner that is not dependent but enhanced by the FtsZ GTPase activity. Using a combination of biochemical and genetic approaches, we then map the MipZ-FtsZ interaction interface. Our results reveal that MipZ employs a patch of surface-exposed hydrophobic residues to interact with the C-terminal region of the FtsZ core domain. In doing so, it sequesters FtsZ monomers and caps the (+)-end of FtsZ polymers, thereby promoting their rapid disassembly. We further show that MipZ influences the conformational dynamics of interacting FtsZ molecules, which could potentially contribute to modulating their assembly kinetics. Together, our findings show that MipZ uses a combination of mechanisms to control FtsZ polymerization, which may be required to robustly regulate the spatiotemporal dynamics of Z ring assembly within the cell. + + + + Corrales-Guerrero + Laura + L + 0000-0002-0878-5231 + + Department of Biology, University of Marburg, 35043 Marburg, Germany. + + + + Steinchen + Wieland + W + 0000-0003-2990-3660 + + Center for Synthetic Microbiology (SYNMIKRO), 35043 Marburg, Germany. + + + Department of Chemistry, University of Marburg, 35043 Marburg, Germany. + + + + Ramm + Beatrice + B + 0000-0002-7402-1942 + + Department of Cellular and Molecular Biophysics, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany. + + + + Mücksch + Jonas + J + 0000-0002-1469-6956 + + Department of Cellular and Molecular Biophysics, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany. + + + + Rosum + Julia + J + + Department of Biology, University of Marburg, 35043 Marburg, Germany. + + + + Refes + Yacine + Y + + Department of Biology, University of Marburg, 35043 Marburg, Germany. + + + + Heimerl + Thomas + T + + Center for Synthetic Microbiology (SYNMIKRO), 35043 Marburg, Germany. + + + + Bange + Gert + G + 0000-0002-7826-0932 + + Center for Synthetic Microbiology (SYNMIKRO), 35043 Marburg, Germany. + + + Department of Chemistry, University of Marburg, 35043 Marburg, Germany. + + + Max Planck Fellow Group Molecular Physiology of Microbes, Max Planck Institute for Terrestrial Microbiology, 35043 Marburg, Germany. + + + + Schwille + Petra + P + 0000-0002-6106-4847 + + Department of Cellular and Molecular Biophysics, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany. + + + + Thanbichler + Martin + M + 0000-0002-1303-1442 + + Department of Biology, University of Marburg, 35043 Marburg, Germany. + + + Center for Synthetic Microbiology (SYNMIKRO), 35043 Marburg, Germany. + + + Max Planck Fellow Group Bacterial Cell Biology, Max Planck Institute for Terrestrial Microbiology, 35043 Marburg, Germany. + + + + eng + + + project 269423233 + Deutsche Forschungsgemeinschaft (DFG) + + + + Project 324652314 + Deutsche Forschungsgemeinschaft (DFG) + + + + Max Planck Fellowship + Max-Planck-Gesellschaft (MPG) + + + + Marie Sklodowska-Curie grant - agreement No 6591 + EC | Horizon 2020 Framework Programme (H2020) + + + + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + Proc Natl Acad Sci U S A + 7505876 + 0027-8424 + + IM + + FtsZ inhibitor + bacterial cell division + cytoskeleton + division site placement + divisome + +
+ + + + 2022 + 12 + 9 + 13 + 52 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + ppublish + + 36490318 + 10.1073/pnas.2208227119 + + +
+ + + 36490319 + + 2022 + 12 + 09 + +
+ + 1096-9101 + + + 2022 + Dec + 09 + + + Lasers in surgery and medicine + Lasers Surg Med + + Electrochemical lipolysis of subcutaneous adipose tissue in a porcine animal model. + 10.1002/lsm.23621 + + There is a considerable demand for noninvasive low-cost fat reduction methods with fewer side effects and shorter recovery times. This study aims to develop a fat-reduction method through electrochemical lipolysis of subcutaneous adipocytes using needle-based electrodes, body tissue fluids, and electrical current application. + Electrochemical lipolysis was performed by inserting a 4-pin needle electrode connected to a DC power supply into the pig's abdomen. Applied electrical current (0.5 and 1 mA) and treatment time (5 or 10 minutes) were varied systematically. Ultrasound imaging was performed before and after treatment to determine changes in fat thickness. Tissue samples were collected at 0, 2, and 4 weeks posttreatment for histological evaluation to determine the mechanism of action and the procedure's efficacy. + Electrochemical subcutaneous adipose tissue lipolysis in a porcine model was achieved through hydrolysis of physiologic fluid within the vicinity of the inserted electrode where an electric current is applied, leading to localized disruption of fat cell membranes and necrosis. Electric current configuration 1.0 mA showed more pronounced lipolysis effects applied for 10 minutes, significantly decreasing adipocyte content per treatment area. The electrochemical treatment method also stimulates collagen synthesis, which helps reduce fat. + Electrochemical lipolysis is a potential new noninvasive localized technique to reduce fat. The treatment method induces fat cell necrosis via in situ reduction-oxidation reaction by the electrochemical activation of physiologic fluid in the surrounding tissue. Electrochemical lipolysis is a simple, low-cost, fat-reducing treatment method without harmful side effects. + © 2022 Wiley Periodicals LLC. + + + + Bae + Jun Sang + JS + https://orcid.org/0000-0003-2589-797X + + Department of Otorhinolaryngology, College of Medicine, Dankook University, Cheonan, Korea. + + + Beckman Laser Institute-Korea, College of Medicine, Dankook University, Cheonan, Korea. + + + Medical Laser Center, College of Medicine, Dankook University, Cheonan, Korea. + + + + Abueva + Celine D G + CDG + https://orcid.org/0000-0002-8402-7838 + + Beckman Laser Institute-Korea, College of Medicine, Dankook University, Cheonan, Korea. + + + Medical Laser Center, College of Medicine, Dankook University, Cheonan, Korea. + + + + Park + Geun Hwan + GH + + Jeju Refresh Otorhinolaryngology Clinic, Jeju-do, Korea. + + + + Kim + Sehwan + S + + Beckman Laser Institute-Korea, College of Medicine, Dankook University, Cheonan, Korea. + + + Department of Biomedical Engineering, College of Medicine, Dankook University, Cheonan-si, Korea. + + + + Mo + Ji-Hun + JH + http://orcid.org/0000-0003-1331-364X + + Department of Otorhinolaryngology, College of Medicine, Dankook University, Cheonan, Korea. + + + Beckman Laser Institute-Korea, College of Medicine, Dankook University, Cheonan, Korea. + + + Medical Laser Center, College of Medicine, Dankook University, Cheonan, Korea. + + + + Ryu + Hyun Seok + HS + + Interdisciplinary Program for Medical Laser, Dankook University, Cheonan, Korea. + + + + Chung + Phil-Sang + PS + + Department of Otorhinolaryngology, College of Medicine, Dankook University, Cheonan, Korea. + + + Beckman Laser Institute-Korea, College of Medicine, Dankook University, Cheonan, Korea. + + + Medical Laser Center, College of Medicine, Dankook University, Cheonan, Korea. + + + + Woo + Seung Hoon + SH + https://orcid.org/0000-0001-7560-1140 + + Department of Otorhinolaryngology, College of Medicine, Dankook University, Cheonan, Korea. + + + Beckman Laser Institute-Korea, College of Medicine, Dankook University, Cheonan, Korea. + + + Medical Laser Center, College of Medicine, Dankook University, Cheonan, Korea. + + + + eng + + Case Reports + + + 2022 + 12 + 09 + +
+ + United States + Lasers Surg Med + 8007168 + 0196-8092 + + IM + + adipose + electrochemical lipolysis + fat reduction + lipolysis + +
+ + + + 2022 + 11 + 14 + + + 2022 + 08 + 30 + + + 2022 + 11 + 25 + + + 2022 + 12 + 9 + 13 + 53 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36490319 + 10.1002/lsm.23621 + + + REFERENCES + + Hedayati B, Juhász M, Chu S, Mesinkovska NA. Adverse events associated with cryolipolysis: a systematic review of the literature. Dermatol Surg. 2020;46:S8-13. + + + Goldberg DJ. Deletion of adipocytes induced by a novel device simultaneously delivering synchronized radiofrequency and hifem: human histological study. J Cosmet Dermatol. 2021;20(4):1104-9. + + + Martins MG, Martins MIM, de Souza AH, Antunes FTT, Pail PB, de Fátima Wiilland E, et al. Evaluation of lipolysis and toxicological parameters of low-level laser therapy at different wavelengths and doses in the abdominal subcutaneous tissue. Lasers Med Sci. 2022;37(2):1235-44. + + + Oh S, Kim HM, Batsukh S, Sun HJ, Kim T, Kang D, et al. High-intensity focused ultrasound induces adipogenesis via control of cilia in adipose-derived stem cells in subcutaneous adipose tissue. Int J Mol Sci. 2022;23(16):8866. + + + Afrooz PN, Pozner JN, DiBernardo BE. Noninvasive and minimally invasive techniques in body contouring. Clin Plast Surg. 2014;41(4):789-804. + + + Alizadeh Z, Halabchi F, Mazaheri R, Abolhasani M, Tabesh M. Review of the mechanisms and effects of noninvasive body contouring devices on cellulite and subcutaneous fat. Int J Endocrinol Metab. 2016;14(4):e36727. + + + Nestor MS, Newburger J, Zarraga MB. Body contouring using 635-nm low level laser therapy. Semin Cutan Med Surg. 2013;32(1):35-40. + + + Moy WJ, Su E, Chen JJ, Oh C, Jing JC, Qu Y, et al. Association of electrochemical therapy with optical, mechanical, and acoustic impedance properties of porcine skin. JAMA Facial Plastic Surg. 2017;19(6):502-9. + + + Hunter BM, Kallick J, Kissel J, Herzig M, Manuel C, Protsenko D, et al. Controlled-potential electromechanical reshaping of cartilage. Angew Chem Int Ed Engl. 2016;55(18):5497-5500. + + + Hu AC, Hong EM, Toubat O, Sivoraphonh R, Barnes C, Moy WJ, et al. Multiphoton microscopy of collagen structure in ex vivo human skin following electrochemical therapy. Lasers Surg Med. 2020;52(3):196-206. + + + Pham TT, Hong EM, Moy WJ, Zhao J, Hu AC, Barnes CH, et al. The biophysical effects of localized electrochemical therapy on porcine skin. J Dermatol Sci. 2020;97(3):179-86. + + + Chiappe de Cingolani GE, Vega FV. Effect of pH on lipolysis, cAMP and cAMP-dependent protein kinase activity in isolated rat fat cells. Arch Int Physiol Biochim. 1980;88(5):497-503. + + + Greenberg AS, Shen WJ, Muliro K, Patel S, Souza SC, Roth RA, et al. Stimulation of lipolysis and hormone-sensitive lipase via the extracellular signal-regulated kinase pathway. J Biol Chem. 2001;276(48):45456-61. + + + Koopman R, Schaart G, Hesselink MK. Optimisation of oil red O staining permits combination with immunofluorescence and automated quantification of lipids. Histochem Cell Biol. 2001;116(1):63-8. + + + Hutchison DM, Hakimi AA, Hong EM, Pham TT, Wijayaweera A, Seo S, et al. Electrochemolipolysis of human adipose tissue. Facial Plastic Surg Aesthet Med. 2020;22(2):86-92. + + + Kolonin MG, Saha PK, Chan L, Pasqualini R, Arap W. Reversal of obesity by targeted ablation of adipose tissue. Nature Med. 2004;10(6):625-32. + + + Decorato JW, Chen B, Sierra R. Subcutaneous adipose tissue response to a non-invasive hyperthermic treatment using a 1,060 nm laser. Lasers Surg Med. 2017;49(5):480-9. + + + Kwon T-R, Kim JH, Jang YN, Lee S-E, Hong J-Y, Yoo KH, et al. Comparison of different energy response for lipolysis using a 1,060-nm laser: an animal study of three pigs. Skin Res Technol. 2021;27(1):5-14. + + + Bechara FG, Mannherz HG, Jacob M, Mazur AJ, Sand M, Altmeyer P, et al. Induction of fat cell necrosis in human fat tissue after treatment with phosphatidylcholine and deoxycholate. J Eur Acad Dermatol Venereol. 2012;26(2):180-5. + + + Herold C, Rennekampff HO, Engeli S. Apoptotic pathways in adipose tissue. Apoptosis. 2013;18(8):911-6. + + + Arandjelovic S, Ravichandran KS. Phagocytosis of apoptotic cells in homeostasis. Nature Immunol. 2015;16(9):907-17. + + + Xue M, Jackson CJ. Extracellular matrix reorganization during wound healing and its impact on abnormal scarring. Adv Wound Care. 2015;4(3):119-36. + + + Manuel CT, Foulad A, Protsenko DE, Hamamoto A, Wong BJF. Electromechanical reshaping of costal cartilage grafts: a new surgical treatment modality. Laryngoscope. 2011;121(9):1839-42. + + + Oliaei S, Manuel C, Karam B, Hussain SF, Hamamoto A, Protsenko DE, et al. In vivo electromechanical reshaping of ear cartilage in a rabbit model: a minimally invasive approach for otoplasty. JAMA Facial Plastic Surgery. 2013;15(1):34-8. + + + +
+ + + 36490322 + + 2022 + 12 + 09 + +
+ + 1557-3125 + + + 2022 + Dec + 09 + + + Molecular cancer research : MCR + Mol Cancer Res + + Improved delineation of colorectal cancer molecular subtypes and functional profiles with a 62-gene panel. + MCR-22-0476 + 10.1158/1541-7786.MCR-22-0476 + + Since its establishment in 2015, the transcriptomics-based consensus molecular subtype (CMS) classification has unified our understanding of colorectal cancer (CRC). Each of the four CMS exhibited distinctive high-level molecular signatures that correlated well with prognosis and treatment response. Nonetheless, many key aspects of CRC progression and intra-subtype heterogeneity remain unresolved. This is partly because the bulk transcriptomic data used to define CMS contain substantial interference from non-tumor cells. Here, we propose a concise panel of 62 genes that not only accurately recapitulates all key characteristics of the four original CMS but also identifies three additional subpopulations with unique molecular signatures. Validation on independent cohorts confirm that the new CMS4 intra-subtypes coincide with single-cell-derived intrinsic subtypes and that the panel consists of many immune cell type markers that can capture the status of tumor microenvironment. Furthermore, a 2D embedding of CMS structure based on the proposed gene panel provides a high-resolution view of the functional pathways and cell type markers that underlie each CMS intra-subtype and the continuous progression from CMS2 to CMS4 subtypes. Our gene panel and 2D visualization refined the delineation of CRC subtypes and could aid further discovery of molecular mechanisms in CRC. Implications: Well-selected gene panel and representation can capture both the continuum of cancer cell states and tumor microenvironment status. + + + + Bhukdee + Dhup + D + 0000-0003-1984-1996 + + Mahidol University International College, Phutthamonthon, Nakhon Pathom, Thailand. + + + + Nuwongsri + Pattarin + P + 0000-0002-3253-9655 + + Chulalongkorn University, Bangkok, Bangkok, Thailand. + + + + Israsena + Nipan + N + 0000-0003-1954-6567 + + Chulalongkorn University, Bangkok, -, Thailand. + + + + Sriswasdi + Sira + S + 0000-0002-4117-3632 + + Chulalongkorn University, Bangkok, -, Thailand. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + Mol Cancer Res + 101150042 + 1541-7786 + + IM +
+ + + + 2022 + 12 + 07 + + + 2022 + 06 + 16 + + + 2022 + 11 + 01 + + + 2022 + 12 + 9 + 13 + 53 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36490322 + 711589 + 10.1158/1541-7786.MCR-22-0476 + + +
+ + + 36490320 + + 2022 + 12 + 09 + +
+ + 1752-0606 + + + 2022 + Dec + 09 + + + Journal of marital and family therapy + J Marital Fam Ther + + Sexual Health and Integrative Pleasure (SHIP) Model: Using a clinical case example to guide assessment and treatment. + 10.1111/jmft.12624 + + This manuscript presents a conceptual model-the Sexual Health and Integrative Pleasure (SHIP) Model-for the clinical assessment and intervention of sexual health concerns. The model was developed by a group of couple/marital family therapy and psychologists who specialize in the treatment of sexual problems. The model consists of five philosophical foundations (systems framework, intersectionality, biopsychosocial model, lifespan approach, and empiricism) and five core therapeutic components (sexual literacy, sexual adaptation and resilience, relational intimacy, pleasure-oriented positive sexuality, and multidisciplinary care). We define each foundation and component, and compare and contrast the SHIP model with other existing sexual health models. Finally, we demonstrate how the SHIP model was used to provide individual and couple therapy with a cis/heterosexual couple in a university-based sexual health clinic and make recommendations for additional clinical applications of the model. + © 2022 The Authors. Journal of Marital and Family Therapy published by Wiley Periodicals LLC on behalf of American Association for Marriage and Family Therapy. + + + + Girard + Abby + A + http://orcid.org/0000-0001-5102-844X + + Department of Family Medicine and Community Health, Institute for Sexual and Gender Health, University of Minnesota, Minneapolis, Minnesota, USA. + + + + Newstrom + Nicholas P + NP + + Marriage and Family Therapy Program, St Cloud State University, St Cloud, Minnesota, USA. + + + + Connor + Jennifer + J + + Department of Family Medicine and Community Health, Institute for Sexual and Gender Health, University of Minnesota, Minneapolis, Minnesota, USA. + + + + Arenella + Katherine + K + + California School of Professional Psychology, Alliant International University-Los Angeles, Los Angeles, California, USA. + + + + Vencill + Jennifer + J + + Department of Psychiatry and Psychology, Division of General Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA. + + + + Robinson + Beatrice Bean + BB + + Department of Family Medicine and Community Health, Institute for Sexual and Gender Health, University of Minnesota, Minneapolis, Minnesota, USA. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + J Marital Fam Ther + 7904614 + 0194-472X + + IM + + Clinical + Couples + Diversity + Intervention/Technique + Populations + Practice Development + Professional/Practice Issues + Theory/Model + +
+ + + + 2022 + 11 + 22 + + + 2022 + 01 + 14 + + + 2022 + 11 + 29 + + + 2022 + 12 + 9 + 13 + 53 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36490320 + 10.1111/jmft.12624 + + + REFERENCES + + Annon, J. S. (1975). The behavioral treatment of sexual problems, vol. 1: Brief therapy. Harper & Row. + + + Annon, J. S. (1976). The behavioral treatment of sexual problems, vol. 2: Intensive therapy. Enabling Systems. + + + Beck, A. M., & Robinson, J. W. (2015). Sexual resilience in couples. In K. Skerrett, & K. Fergus (Eds.), Couple resilience: Emerging perspectives (pp. 63-82). Springer. https://doi.org/10.1007/978-94-017-9909-6_4 + + + Bengtson, V. L., & Allen, K. R. (1993). The life course perspective applied to families over time. In P. G. Boss, W. J. Doherty, R. LaRossa, W. R. Schumm, & S. K. Steinmetz (Eds.), Sourcebook of family theories and methods: A contextual approach (pp. 469-504). Plenum Press. https://doi.org/10.1007/978-0-387-85764-0_19 + + + Berry, M. D., & Berry, P. D. (2013). Mentalization-based therapy for sexual addiction: Foundations for a clinical model. Sexual and Relationship Therapy, 29, 245-260. https://doi.org/10.1080/14681994.2013.856516 + + + Bubolz, M. M., & Sontag, M. S. (1993). Human ecology theory. In P. G. Boss, W. J. Doherty, R. LaRossa, W. R. Schumm, & S. K. Steinmetz (Eds.), Sourcebook of family theories and methods: A contextual approach (pp. 419-450). Plenum Press. https://doi.org/10.1007/978-0-387-85764-0_17 + + + Burnes, T. R., Singh, A. A., & Witherspoon, R. G. (2017). Sex positivity and counseling psychology: An introduction to the major contribution. The Counseling Psychologist, 45(4), 470-486. https://doi.org/10.1177/0011000017710216 + + + Crenshaw, K. (1991). Mapping the margins: Intersectionality, identity politics, and violence against women of color. Stanford Law Review, 43(6), 1241. https://doi.org/10.2307/1229039 + + + Donaghue, C. (2015). Sex outside the lines: Authentic sexuality in a sexually dysfunctional culture. BenBella Books. + + + Eaton, T., Abeles, N., & Gutfreund, M. (1993). Negative indicators, therapeutic alliance, and therapy outcome. Psychotherapy Research, 3(2), 115-123. https://doi.org/10.1080/10503309312331333719 + + + Fitzpatrick, M. R., Iwakabe, S., & Stalikas, A. (2005). Perspective divergence in the working alliance. Psychotherapy Research, 15(1-2), 69-80. https://doi.org/10.1080/10503300512331327056 + + + Foley, S., Wittmann, D., & Balon, R. (2010). A multidisciplinary approach to sexual dysfunction in medical education. Academic Psychiatry, 34(5), 386-389. https://doi.org/10.1176/appi.ap.34.5.386 + + + Fraley, R. C., Heffernan, M. E., Vicary, A. M., & Brumbaugh, C. C. (2011). The Experiences in Close Relationships-Relationship Structures questionnaire: A method for assessing attachment orientations across relationships. Psychological Assessment, 23(3), 615-625. https://doi.org/10.1037/a0022898 + + + Fried, E. I. (2020). Theories and models: What they are, what they are for, and what they are about. Psychological Inquiry, 31(4), 336-344. https://doi.org/10.1037/a0022898 + + + Glickman, C. (2000). The language of sex positivity. Electronic Journal of Human Sexuality, 3, 1-5. + + + Gottman, J., & Silver, N. (1999). The seven principles for making marriage work: A practical guide from the country's foremost relationship expert. Harmony Books. + + + Hendrick, S. S. (1988). A generic measure of relationship satisfaction. Journal of Marriage and the Family, 50(1), 93-98. https://doi.org/10.2307/352430 + + + Heredia Jr., D., & Rider, G. N. (2020). Intersectionality in sex therapy: Opportunities for promoting sexual wellness among queer people of color. Current Sexual Health Reports, 12(3), 195-201. https://doi.org/10.1007/s11930-020-00270-8 + + + Hertlein, K. M., Weeks, G. R., & Gambescia, N. (Eds.). (2015). Systemic sex therapy (2nd ed.). Routledge. + + + Howard, K. I., Lueger, R. J., Maling, M. S., & Martinovich, Z. (1993). A phase model of psychotherapy outcome: Causal mediation of change. Journal of Consulting and Clinical Psychology, 61(4), 678-685. https://doi.org/10.1037/0022-006X.61.4.678 + + + Johnson, S. M. (2004). The practice of emotionally focused couple therapy (2nd ed.). Brunner-Routledge. + + + Meana, M., Hall, K., & Binik, Y. M. (2014). Sex therapy in transition: Are we there yet? In M. Binik, & K. S. K. Hall (Eds.), Principles and practice of sex therapy (5th ed., pp. 541-547). Guilford Press. + + + Metz, M. E., Epstein, N. B., & McCarthy, B. (2018). Cognitive-behavioral therapy for sexual dysfunction. Routledge/Taylor & Francis Group. + + + Miner, M. H., Coleman, E., Center, B. A., Ross, M., & Rosser, B. R. S. (2007). The compulsive sexual behavior inventory: Psychometric properties. Archives of Sexual Behavior, 36(4), 579-587. https://doi.org/10.1007/s10508-006-9127-2 + + + Nadal, K. L. (2013). That's so gay! Microaggressions and the lesbian, gay, bisexual, and transgender community. American Psychological Association. + + + O'Donovan, A. (2010). Sex and sexuality across the lifespan. In C. Butler, A. O'Donovan, & E. Shaw (Eds.), Sex, sexuality and therapeutic practice: A manual for therapists and trainers (pp. 129-159). Routledge/Taylor & Francis Group. + + + Osborne, R. H., Batterham, R. W., Elsworth, G. R., Hawkins, M., & Buchbinder, R. (2013). The grounded psychometric development and initial validation of the Health Literacy Questionnaire (HLQ). BMC Public Health, 13, 658. https://doi.org/10.1186/1471-2458-13-658 + + + Reissing, E. D., & Giulio, G. D. (2010). Practicing clinical psychologists' provision of sexual health care services. 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+ + + 36490321 + + 2022 + 12 + 09 + +
+ + 1520-5126 + + + 2022 + Dec + 09 + + + Journal of the American Chemical Society + J Am Chem Soc + + Accessing Diverse Azole Carboxylic Acid Building Blocks via Mild C-H Carboxylation: Parallel, One-Pot Amide Couplings and Machine-Learning-Guided Substrate Scope Design. + 10.1021/jacs.2c10557 + + This manuscript describes a mild, functional group tolerant, and metal-free C-H carboxylation that enables direct access to azole-2-carboxylic acids, followed by amide coupling in one pot. This demonstrates a significant expansion of the accessible chemical space of azole-2-amides, compared to previously known methodologies. Key to the described reactivity is the use of silyl triflate reagents, which serve as reaction mediators in C-H deprotonation and stabilizers of (otherwise unstable) azole carboxylic acid intermediates. A diverse azole substrate scope designed via machine-learning-guided analysis demonstrates the broad utility of the sequence. Density functional theory calculations provide detailed insights into the role of silyl triflates in the reaction mechanism. Transferrable applications of the protocol are successfully established: (i) A low pressure (CO2 balloon) option for synthesizing azole-2-carboxylic acids without the need for high-pressure equipment; (ii) the use of 13CO2 for the synthesis of labeled compounds; (iii) isocyanates as alternative electrophiles for direct C-H amidation; (iv) and the use of the developed chemistry in a 24 × 12 parallel synthesis workflow with a 90% library success rate. Fundamentally, the reported protocol expands the use of heterocycle C-H functionalization from late-stage functionalization applications toward its use in library synthesis. It provides general access to densely functionalized azole-2-carboxylic acid building blocks and demonstrates their one-pot diversification. + + + + Felten + Stephanie + S + 0000-0002-5477-5026 + + Process Research & Development, MRL, Merck & Co. Inc, 126 E Lincoln Avenue, Rahway, New Jersey 07065, United States. + + + + He + Cyndi Qixin + CQ + + Computational and Structural Chemistry, MRL, Merck & Co. Inc, 126 E Lincoln Avenue, Rahway, New Jersey 07065, United States. + + + + Weisel + Mark + M + + Process Research & Development, MRL, Merck & Co. Inc, 126 E Lincoln Avenue, Rahway, New Jersey 07065, United States. + + + + Shevlin + Michael + M + 0000-0003-2566-5095 + + Process Research & Development, MRL, Merck & Co. Inc, 126 E Lincoln Avenue, Rahway, New Jersey 07065, United States. + + + + Emmert + Marion H + MH + 0000-0003-4375-8295 + + Process Research & Development, MRL, Merck & Co. Inc, 126 E Lincoln Avenue, Rahway, New Jersey 07065, United States. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + J Am Chem Soc + 7503056 + 0002-7863 + + IM +
+ + + + 2022 + 12 + 9 + 13 + 53 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36490321 + 10.1021/jacs.2c10557 + + +
+ + + 36490323 + + 2022 + 12 + 09 + +
+ + 1520-6882 + + + 2022 + Dec + 09 + + + Analytical chemistry + Anal Chem + + Hyperactive DNA Cutting for Unbiased UHPLC-MS/MS Quantification of Epigenetic DNA Marks by Engineering DNase I Mutants. + 10.1021/acs.analchem.2c04485 + + Epigenetic DNA modifications, such as 5-methylcytosine, 5-hydroxymethylcytosine, and 5-formylcytosine, are associated with a variety of diseases and potential biomarkers for cancer diagnosis and therapy. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) assays are considered to be the gold standard for qualitative and quantitative detection of DNA modifications. DNA digestion for converting long DNA polymer into 2'-deoxynucleosides is an important preprocessing step to achieve sensitive and accurate LC-MS/MS quantification. Here, we showed that, as stimulated by divalent metal ions, Mg2+ and Mn2+, the engineered human DNase I Q9R:E13R:N74K mutant can efficiently digest DNA in the presence of monovalent metal ions at a high concentration (e.g., 1 M NaCl), showing hyperactivity on DNA cutting. We also found that the engineered DNase I mutants display exceptional DNA-cutting activity over a wider pH range (5.5-9.5). Due to their hyperactivity and high salt tolerance, the engineered DNase I mutants cut DNA 5mC and dC efficiently. Benefitting from this DNA-cutting hyperactivity, we demonstrated an LC-MS/MS assay for unbiased and accurate quantification of DNA 5mC. + + + + Song + Xingrui + X + + Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China. + + + State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China. + + + + Song + Xinyue + X + + State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China. + + + + Lai + Weiyi + W + 0000-0002-8010-2490 + + State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China. + + + University of Chinese Academy of Sciences, Beijing 100049, China. + + + + Wang + Hailin + H + 0000-0002-1843-999X + + Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China. + + + State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China. + + + University of Chinese Academy of Sciences, Beijing 100049, China. + + + + eng + + Journal Article + + + 2022 + 12 + 09 + +
+ + United States + Anal Chem + 0370536 + 0003-2700 + + IM +
+ + + + 2022 + 12 + 9 + 13 + 53 + + + 2022 + 12 + 10 + 6 + 0 + + + 2022 + 12 + 10 + 6 + 0 + + + aheadofprint + + 36490323 + 10.1021/acs.analchem.2c04485 + + +
+
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+ + 2165-0497 + + + 2023 + Feb + 21 + + + Microbiology spectrum + Microbiol Spectr + + Novel In Situ Hybridization Assay for Chromogenic Single-Molecule Detection of Human Papillomavirus E6/E7 mRNA. + + e0389622 + + 10.1128/spectrum.03896-22 + + RNA plays a vital role in the physiological and pathological processes of cells and tissues. However, RNA in situ hybridization applications in clinical diagnostics are still limited to a few examples. In this study, we developed a novel in situ hybridization assay for human papillomavirus (HPV) E6/E7 mRNA by taking advantage of specific padlock probing and rolling circle amplification, combined with chromogenic readout. We designed padlock probes for 14 types of high-risk HPV and demonstrated that E6/E7 mRNA could be visualized in situ as discrete dot-like signals using bright-field microscopy. Overall, the results are consistent with the clinical diagnostics lab's hematoxylin and eosin (H&E) staining and p16 immunohistochemistry test results. Our work thus shows the potential applications of RNA in situ hybridization for clinical diagnostics using chromogenic single-molecule detection, offering an alternative technical option to the current commercially available kit based on branched DNA technology. IMPORTANCE In situ detection of viral mRNA expression in tissue samples is of great value for pathological diagnosis to access viral infection status. Unfortunately, conventional RNA in situ hybridization assays lack sensitivity and specificity for clinical diagnostic purposes. Currently, the commercially available branched DNA technology-based single-molecule RNA in situ detection method offers satisfactory results. Here, we present our padlock probe- and rolling circle amplification-based RNA in situ hybridization assay for detecting HPV E6/E7 mRNA expression in formalin-fixed paraffin-embedded tissue sections, providing an alternative yet robust method for viral RNA in situ visualization that is also applicable to different types of diseases. + + + + Rao + Xuelian + X + + School of Medicine, Huaqiao University, Xiamen, Fujian, China. + + + + Zheng + Liangkai + L + + Department of Pathology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China. + + + + Wei + Kaipeng + K + + Department of Pathology, The 910th Hospital, Quanzhou, Fujian, China. + + + + Li + Meiqing + M + + Department of Pathology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China. + + + + Jiang + Meng + M + + School of Medicine, Huaqiao University, Xiamen, Fujian, China. + + + + Qiu + Jianlong + J + + Department of Pathology, The 910th Hospital, Quanzhou, Fujian, China. + + + + Zhou + Yulin + Y + + United Diagnostic and Research Center for Clinical Genetics, Women and Children's Hospital, School of Medicine and School of Public Health, Xiamen University, Xiamen, Fujian, China. + + + + Ke + Rongqin + R + 0000-0002-9868-3713 + + School of Medicine, Huaqiao University, Xiamen, Fujian, China. + + + + Lin + Chen + C + + School of Medicine, Huaqiao University, Xiamen, Fujian, China. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Microbiol Spectr + 101634614 + 2165-0497 + + IM + + RNA in situ hybridization + human papillomavirus + padlock probe + rolling circle amplification + +
+ + + + 2023 + 2 + 22 + 13 + 32 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809088 + 10.1128/spectrum.03896-22 + + +
+ + + 36809091 + + 2023 + 02 + 22 + +
+ + 1087-2108 + + 28 + 6 + + 2022 + Dec + 15 + + + Dermatology online journal + Dermatol Online J + + Trichodysplasia spinulosa: a presentation of polyomavirus infection in immunosuppressed patients. + 10.5070/D328659724 + + Trichodysplasia spinulosa (TS) is a rare skin condition that occurs mainly in immunosuppressed patients. Although initially postulated to be an adverse effect of immunosuppressants, TS-associated polyomavirus (TSPyV) has since been isolated from TS lesions and is now considered to be the causative agent. Trichodysplasia spinulosa presents with folliculocentric papules with protruding keratin spines, most commonly on the central face. Trichodysplasia spinulosa can be diagnosed clinically, but the diagnosis can be confirmed with histopathological examination. Histological findings include the presence of hyperproliferating inner root sheath cells containing large eosinophilic trichohyaline granules. Polymerase chain reaction (PCR) can also be used to detect and quantify TSPyV viral load. Owing to the paucity of reports in the literature, TS is frequently misdiagnosed and there is no high-quality evidence to guide management. Herein, we present a renal transplant recipient with TS that did not respond to topical imiquimod but improved upon treatment with valganciclovir and reduction of the mycophenolate mofetil dose. Our case highlights the inverse relationship between immune status and disease progression in this condition. + + + + Ji-Xu + Antonio + A + + + Artounian + Kimberly + K + + + Fung + Maxwell A + MA + + + Burrall + Barbara A + BA + + Department of Dermatology, University of California, Davis, Sacramento, California, USA. baburrall@ucdavis.edu. + + + + eng + + Journal Article + + + 2022 + 12 + 15 + +
+ + United States + Dermatol Online J + 9610776 + 1087-2108 + + IM +
+ + + + 2022 + 12 + 27 + + + 2022 + 12 + 27 + + + 2023 + 2 + 22 + 13 + 32 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809091 + 10.5070/D328659724 + + +
+ + + 36809089 + + 2023 + 02 + 22 + +
+ + 1087-2108 + + 28 + 6 + + 2022 + Dec + 15 + + + Dermatology online journal + Dermatol Online J + + Characteristics of patients with juvenile dermatomyositis from 2001-2021 at a tertiary care center. + 10.5070/D328659719 + + Juvenile dermatomyositis (JDM) is the most common inflammatory myopathy in the pediatric population and can represent a medical emergency. However, many features of JDM remain poorly understood, disease presentation is highly variable, and predictors of disease course have yet to be identified. + This retrospective chart review included 47 JDM patients seen at a tertiary care center over a 20-year period. Characteristics such as demographics, clinical signs and symptoms, antibody positivity, dermatopathology features, and treatments were recorded. + All patients had evidence of cutaneous involvement, whereas 88.4% experienced muscle weakness. Constitutional symptoms and dysphagia were commonly present. The most frequent cutaneous findings were Gottron papules, heliotrope rash, and nailfold changes. Anti-TIF1? was the most prevalent myositis-specific autoantibody. Management involved systemic corticosteroids in nearly all cases. Strikingly, the dermatology department was only involved in the care of four in every ten (19/47) patients. + Prompt recognition of the strikingly reproducible skin findings present in JDM can improve disease outcomes in this population. This study highlights the need for increased education of such pathognomonic findings as well as more multidisciplinary care. In particular, a dermatologist should be involved in the care of patients presenting with muscle weakness and skin changes. + + + + Simmons + Elanee + E + + + Kazmi + Maha + M + + + Wilson + Machelle + M + + + Kiuru + Maija + M + + + Tartar + Danielle M + DM + + Department of Dermatology, University of California Davis, Sacramento, California. DTartar@UCDavis.edu. + + + + eng + + Journal Article + + + 2022 + 12 + 15 + +
+ + United States + Dermatol Online J + 9610776 + 1087-2108 + + IM +
+ + + + 2022 + 12 + 26 + + + 2022 + 12 + 26 + + + 2023 + 2 + 22 + 13 + 32 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809089 + 10.5070/D328659719 + + +
+ + + 36809086 + + 2023 + 02 + 22 + +
+ + 1619-3997 + + + 2023 + Feb + 22 + + + Journal of perinatal medicine + J Perinat Med + + Stem cell programming - prospects for perinatal medicine. + 10.1515/jpm-2022-0575 + + Recreating human cell and organ systems in vitro has tremendous potential for disease modeling, drug discovery and regenerative medicine. The aim of this short overview is to recapitulate the impressive progress that has been made in the fast-developing field of cell programming during the past years, to illuminate the advantages and limitations of the various cell programming technologies for addressing nervous system disorders and to gauge their impact for perinatal medicine. + © 2023 Walter de Gruyter GmbH, Berlin/Boston. + + + + Berg + Lea J + LJ + https://orcid.org/0000-0002-2746-6519 + + Institute of Reconstructive Neurobiology, University of Bonn Medical Faculty and University Hospital Bonn, Bonn, Germany. + + + + Brüstle + Oliver + O + https://orcid.org/0000-0002-1277-0980 + + Institute of Reconstructive Neurobiology, University of Bonn Medical Faculty and University Hospital Bonn, Bonn, Germany. + + + + eng + + Journal Article + Review + + + 2023 + 02 + 22 + +
+ + Germany + J Perinat Med + 0361031 + 0300-5577 + + IM + + cellular reprogramming techniques + disease models + regenerative medicine + +
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+ + + 36809092 + + 2023 + 02 + 22 + +
+ + 1087-2108 + + 28 + 6 + + 2022 + Dec + 15 + + + Dermatology online journal + Dermatol Online J + + Acne agminata: dermoscopic features and a short review. + 10.5070/D328659725 + + Acne agminata is a rare idiopathic inflammatory dermatosis. Treatment is variable with no clear consensus. We herein report a case of a 31-year-old man with sudden onset papulonodular eruptions on his face over two months. Histopathological examination revealed superficial granuloma composed of epithelioid histiocytes and scattered multinucleated giant cells, confirming acne agminata. Dermoscopy showed focal orangish structureless areas with follicular openings with white keratotic plugs. He achieved complete clinical resolution with oral prednisolone in 6 weeks. We also reviewed the literature regarding the reported treatment regimens used. + + + + Tan + Wen Hao + WH + + + Goh + Jia Yi + JY + + + Busmanis + Inny + I + + + Oh + Choon Chiat + CC + + Department of Dermatology, Singapore General Hospital, Singapore. oh.choon.chiat@singhealth.com.sg. + + + + eng + + Journal Article + + + 2022 + 12 + 15 + +
+ + United States + Dermatol Online J + 9610776 + 1087-2108 + + IM +
+ + + + 2022 + 12 + 27 + + + 2022 + 12 + 27 + + + 2023 + 2 + 22 + 13 + 32 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809092 + 10.5070/D328659725 + + +
+ + + 36809095 + + 2023 + 02 + 22 + +
+ + 1087-2108 + + 28 + 6 + + 2022 + Dec + 15 + + + Dermatology online journal + Dermatol Online J + + Hitchhiking spider: a case of unilateral vasculitis. + 10.5070/D328659740 + + A 63-year-old man presented with two days of palpable purpura over the right anterior shin and calf with notable point tenderness on the distal mid-calf without any palpable deep abnormality. Localized right calf pain worsened with walking and was associated with headache, chills, fatigue, and low-grade fevers. A punch biopsy of the anterior right lower leg showed necrotizing neutrophilic vasculitis of superficial and deep vessels. Direct immunofluorescence showed non-specific focal granular deposition of C3 within vessel walls. Three days after presentation, a live spider was found and microscopically identified as a male hobo spider. The patient suspected the spider arrived via packages shipped from Seattle, Washington. The patient was treated with a prednisone taper with full resolution of his cutaneous symptoms. Given the unilaterality of his symptoms and otherwise unexplained etiology, the patient was diagnosed with acute unilateral vasculitis secondary to hobo spider bite. Microscopic examination is required for identification of hobo spiders. Although not deadly, there have been several reports of cutaneous and systemic reactions resulting from hobo spider bites. Our case illustrates the importance of considering hobo spider bites in areas outside of their native regions, as they are known to travel in packaged items. + + + + Peterson + Malina Yamashita + MY + + + Han + Joohee + J + + + Xiong + Michelle + M + + + Werling + Robert + R + + + Neeley + Anne + A + + + Scherman + Joseph + J + + + Kozlowski + Anna + A + + Department of Dermatology, HealthPartners Institute, Minneapolis, Minnesota, USA. anna.m.kozlowski@healthpartners.com. + + + + eng + + Journal Article + + + 2022 + 12 + 15 + +
+ + United States + Dermatol Online J + 9610776 + 1087-2108 + + IM +
+ + + + 2022 + 12 + 27 + + + 2022 + 12 + 27 + + + 2023 + 2 + 22 + 13 + 32 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809095 + 10.5070/D328659740 + + +
+ + + 36809093 + + 2023 + 02 + 22 + +
+ + 1087-2108 + + 28 + 6 + + 2022 + Dec + 15 + + + Dermatology online journal + Dermatol Online J + + Primary cutaneous CD4+ small/medium-sized pleomorphic T-cell lymphoproliferative disorder in a young woman. + 10.5070/D328659726 + + Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder (CD4+PCSM-LPD) is a low-grade cutaneous T cell disorder. There is no standardized approach to treatment of CD4+ PCSM-LPD due to its rarity. Herein, we discuss a 33-year-old woman with CD4+PCSM-LPD which resolved after a partial biopsy. We highlight that conservative and local treatment modalities should be considered prior to utilizing more aggressive and invasive treatment options. + + + + Leeolou + Melissa C + MC + + + Young + Peter A + PA + + + Saleem + Atif + A + + + Narala + Saisindhu + S + + + Bae + Gordon H + GH + + Department of Dermatology, Stanford University School of Medicine, Stanford, California, USA. GBae@Stanford.edu. + + + + eng + + Journal Article + + + 2022 + 12 + 15 + +
+ + United States + Dermatol Online J + 9610776 + 1087-2108 + + IM +
+ + + + 2022 + 12 + 27 + + + 2022 + 12 + 27 + + + 2023 + 2 + 22 + 13 + 32 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809093 + 10.5070/D328659726 + + +
+ + + 36809111 + + 2023 + 02 + 22 + +
+ + 1573-286X + + + 2023 + Feb + 21 + + + Sexual abuse : a journal of research and treatment + Sex Abuse + + The Impact of Mental Illness and Intellectual Disability Information on General Public Perceptions of a Person Convicted of a Child Sex Offence. + + 10790632231159072 + + 10.1177/10790632231159072 + + A person convicted of sex offences (PCSO) is confronted with several challenges upon re-entry to the community, often facing difficulties accessing housing and employment, and experiencing stigmatisation, hostility and harassment from community members. Given the importance of community support for successful reintegration, we examined differences in public (N = 117) attitudes toward a PCSO against a child (PCSO-C) with mental illness or intellectual disability compared to a neurotypical PCSO-C in an online survey. At present, differences in attitudes towards these groups has not been explored. Results indicated the PCSO-Cs with intellectual disability or mental illness were seen to pose less risk of sexual reoffending and prompted higher levels of reintegration comfort than the neurotypical PCSO-C. Participants' prior personal exposure to mental illness or intellectual disability was unrelated to attitudes, but those who believed that PCSOs in general have a low capacity for change attributed greater risk of sexual reoffending, greater risk of future harm to children, higher levels of blame and lower reintegration comfort, regardless of MI and ID information. Female participants also perceived greater risk of future harm to adults, and older participants estimated higher risk of sexual reoffending than younger participants. Findings have implications for community acceptance of PCSO-Cs and jury decision-making processes and highlight the importance of public education regarding neurodiverse PCSO-Cs and PCSO capacity for change to encourage knowledge-based judgements. + + + + Brodie + Zara P + ZP + 0000-0002-1361-2239 + + Department of Clinical Psychology, University of Edinburgh, Edinburgh, UK. + + + + Shirlaw + Kirsty + K + + Department of Psychology, 3525Glasgow Caledonian University, Glasgow, UK. + + + + Hand + Christopher J + CJ + + Department of Education, 3526University of Glasgow, Glasgow, UK. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Sex Abuse + 9506704 + 1079-0632 + + IM + + attitudes towards sex offences + child sex offences + intellectual disability + mental illness + +
+ + + + 2023 + 2 + 22 + 13 + 32 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809111 + 10.1177/10790632231159072 + + +
+ + + 36809100 + + 2023 + 02 + 22 + +
+ + 1087-2108 + + 28 + 6 + + 2022 + Dec + 15 + + + Dermatology online journal + Dermatol Online J + + Large, linear pigmentation anomaly: an unusual dyspigmentation case. + 10.5070/D328659729 + + Segmental pigmentation anomalies can be further divided into segmental pigmentation disorder (SPD) complex and café-au-lait macules (CALMs). Both are congenital skin conditions characterized by hyper- or hypopigmentation. Segmental pigmentation disorder is a rare entity, whereas CALMs are common skin lesions that may be associated with various genetic conditions, especially when several are present and the patient has other indicators of a genetic abnormality. When the CALM is segmental, segmental neurofibromatosis (type V) may be considered in the differential diagnosis. Herein we present a 48-year-old woman with a history of malignant melanoma who presented with a large, linear, hyperpigmented patch on her shoulder and arm, present since around birth. The differential diagnosis consisted of CALM versus hypermelanosis (a subtype of SPD). Given a family history of a similar lesion, in addition to a personal and family history of melanoma and internal cancers, a hereditary cancer panel was completed demonstrating genetic variance of uncertain significance. This case brings attention to a rare dyspigmentation disorder and questions a possible association with melanoma. + + + + Vander Does + Ashley + A + + + Motosko + Catherine + C + + + Yosipovitch + Gil + G + + Dr Phillip Frost Department of Dermatology, University of Miami, Miami, Florida, USA. gyosipovitch@med.miami.edu. + + + + eng + + Journal Article + + + 2022 + 12 + 15 + +
+ + United States + Dermatol Online J + 9610776 + 1087-2108 + + IM +
+ + + + 2022 + 12 + 27 + + + 2022 + 12 + 27 + + + 2023 + 2 + 22 + 13 + 32 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809100 + 10.5070/D328659729 + + +
+ + + 36809101 + + 2023 + 02 + 22 + +
+ + 1087-2108 + + 28 + 6 + + 2022 + Dec + 15 + + + Dermatology online journal + Dermatol Online J + + Cerebriform eruption related to acute coral dermatitis. + 10.5070/D328659730 + + A 27-year-old woman presented with an acute, tender, geographic lesion on her left shin that developed after contact with a brain coral while scuba diving. Photographs obtained two hours after the incident reveal a well-demarcated, geographic, erythematous plaque with a serpiginous and cerebriform pattern at the site of contact, resembling the outermost surface contour of brain coral. The plaque resolved spontaneously over a three-week period. The biology of corals and potential biological features that lead to cutaneous eruptions are reviewed. + + + + Dyson + Mary E + ME + + + Kimyai-Asadi + Arash + A + + Division of Dermatology, Department of Medicine, Houston Methodist Hospital, Houston, Texas, USA Department of Dermatology, Weill Cornell Medical College, New York, New York, USA. akimyai@yahoo.com. + + + + eng + + Journal Article + + + 2022 + 12 + 15 + +
+ + United States + Dermatol Online J + 9610776 + 1087-2108 + + IM +
+ + + + 2022 + 12 + 27 + + + 2022 + 12 + 27 + + + 2023 + 2 + 22 + 13 + 32 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809101 + 10.5070/D328659730 + + +
+ + + 36809094 + + 2023 + 02 + 22 + +
+ + 1087-2108 + + 28 + 6 + + 2022 + Dec + 15 + + + Dermatology online journal + Dermatol Online J + + An unexpected case of non-uremic calciphylaxis in a patient with multiple risk factors. + 10.5070/D328659739 + + A 58-year-old woman with a history of morbid obesity, asthma, and prior warfarin use presented to the hospital with shortness of breath and a three-month history of painful, ulcerated ulcers with retiform purpura of her bilateral distal extremities. A punch biopsy specimen demonstrated focal necrosis and hyalinization of the adipose tissue with subtle arteriolar calcium deposition, findings consistent with calciphylaxis. We discuss the presentation of non-uremic calciphylaxis and review the risk factors, pathophysiology, and interdisciplinary management approach of this rare disease. + + + + Nugent + Shannon + S + + + Karaisz + Fred + F + + Department of Internal Medicine, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA. Fred.karaisz@osumc.edu. + + + + Elbadawi + Maisa + M + + + Touati + Andrew + A + + + Nikbakht + Neda + N + + + Lee + Jason B + JB + + + Arif + Hasan + H + + + eng + + Journal Article + + + 2022 + 12 + 15 + +
+ + United States + Dermatol Online J + 9610776 + 1087-2108 + + IM +
+ + + + 2022 + 12 + 27 + + + 2022 + 12 + 27 + + + 2023 + 2 + 22 + 13 + 32 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809094 + 10.5070/D328659739 + + +
+ + + 36809105 + + 2023 + 02 + 22 + +
+ + 1087-2108 + + 28 + 6 + + 2022 + Dec + 15 + + + Dermatology online journal + Dermatol Online J + + Sharps injuries during micrographic surgery and dermatologic oncology fellowship training. + 10.5070/D328659735 + + + Rosales Santillan + Monica + M + + Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts, USA. + + + + Salian + Prerna + P + + + Weiss + Jonathan + J + + + eng + + Journal Article + + + 2022 + 12 + 15 + +
+ + United States + Dermatol Online J + 9610776 + 1087-2108 + + IM +
+ + + + 2022 + 12 + 27 + + + 2022 + 12 + 27 + + + 2023 + 2 + 22 + 13 + 32 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809105 + 10.5070/D328659735 + + +
+ + + 36809103 + + 2023 + 02 + 22 + +
+ + 1087-2108 + + 28 + 6 + + 2022 + Dec + 15 + + + Dermatology online journal + Dermatol Online J + + A case series of tumor necrosis factor inhibitor-induced psoriasis in patients with hidradenitis suppurativa. + 10.5070/D328659732 + + + Kelly + Katherine A + KA + + Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. + + + + Edminister + John + J + + + Pichardo + Rita O + RO + + + Feldman + Steven R + SR + + + eng + + Journal Article + + + 2022 + 12 + 15 + +
+ + United States + Dermatol Online J + 9610776 + 1087-2108 + + IM +
+ + + + 2022 + 12 + 27 + + + 2022 + 12 + 27 + + + 2023 + 2 + 22 + 13 + 32 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809103 + 10.5070/D328659732 + + +
+ + + 36809097 + + 2023 + 02 + 22 + +
+ + 1087-2108 + + 28 + 6 + + 2022 + Dec + 15 + + + Dermatology online journal + Dermatol Online J + + Pyoderma gangrenosum associated with pseudo-Pelger-Huet anomaly in a patient with idiopathic myelofibrosis. + 10.5070/D328659742 + + Pseudo-Pelger-Huët anomaly is a condition in which almost all the granulocytes are hyposegmented and/or hypogranulated. It is typically recognized in peripheral blood smears and represents a marker of several disorders, such as myeloproliferative diseases and myelodysplasia. The occurrence of the pseudo-Pelger-Huët anomaly in the cutaneous infiltrate of pyoderma gangrenosum is very rare. We describe the case of a 70-year-old man with idiopathic myelofibrosis who developed pyoderma gangrenosum. Histological examination showed an infiltrate consisting of granulocytic elements with features of dysmaturity and segmentation anomalies (hypo- and hypersegmented forms), suggestive of pseudo-Pelger-Huët anomaly. Methylprednisolone treatment resulted in progressive improvement of pyoderma gangrenosum. + + + + Furci + Antonio + A + + Department of Medicine, Section of Dermatology, University of Verona, Verona, Italy. + + + + Bruni + Manfredo + M + + + Geat + Davide + D + + + Colato + Chiara + C + + + Girolomoni + Giampiero + G + + + Schena + Donatella + D + + + eng + + Journal Article + + + 2022 + 12 + 15 + +
+ + United States + Dermatol Online J + 9610776 + 1087-2108 + + IM +
+ + + + 2022 + 12 + 27 + + + 2022 + 12 + 27 + + + 2023 + 2 + 22 + 13 + 32 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809097 + 10.5070/D328659742 + + +
+ + + 36809106 + + 2023 + 02 + 22 + +
+ + 1087-2108 + + 28 + 6 + + 2022 + Dec + 15 + + + Dermatology online journal + Dermatol Online J + + Optimizing effective communication between physicians and patients by minimizing language and cultural barriers in health care. + 10.5070/D328659736 + + + Cohen + Philip R + PR + + Department of Dermatology, University of California Davis Medical Center, Sacramento, California, USA Touro University California College of Osteopathic Medicine, Vallejo, California, USA. + + + + eng + + Journal Article + + + 2022 + 12 + 15 + +
+ + United States + Dermatol Online J + 9610776 + 1087-2108 + + IM +
+ + + + 2022 + 12 + 27 + + + 2022 + 12 + 27 + + + 2023 + 2 + 22 + 13 + 32 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809106 + 10.5070/D328659736 + + +
+ + + 36809108 + + 2023 + 02 + 22 + +
+ + 1087-2108 + + 28 + 6 + + 2022 + Dec + 15 + + + Dermatology online journal + Dermatol Online J + + Analysis of patient attitudes and behavior regarding dermatologic care during the COVID-19 pandemic: a survey-based study at a single academic institution. + 10.5070/D328659738 + + + Gao + D X + DX + + Department of Dermatology, Tufts Medical Center, Boston, Massachusetts, USA. + + + + Kahn + J S + JS + + + Cohen + S R + SR + + + Dumont + N + N + + + Yang + F C + FC + + + Rosmarin + D + D + + + eng + + Journal Article + + + 2022 + 12 + 15 + +
+ + United States + Dermatol Online J + 9610776 + 1087-2108 + + IM +
+ + + + 2022 + 12 + 27 + + + 2022 + 12 + 27 + + + 2023 + 2 + 22 + 13 + 32 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809108 + 10.5070/D328659738 + + +
+ + + 36809114 + + 2023 + 02 + 22 + +
+ + 1096-4673 + + 44 + 2 + + 2023 + Feb + + + Issues in mental health nursing + Issues Ment Health Nurs + + Finding Hope in 2023. + + 91 + + 10.1080/01612840.2023.2166773 + + + Thomas + Sandra P + SP + + College of Nursing, University of Tennessee, Knoxville, Knoxville, Tennessee, USA. + + + + eng + + Editorial + +
+ + England + Issues Ment Health Nurs + 7907126 + 0161-2840 + +
+ + + + 2023 + 2 + 22 + 13 + 32 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809114 + 10.1080/01612840.2023.2166773 + + +
+ + + 36809096 + + 2023 + 02 + 22 + +
+ + 1087-2108 + + 28 + 6 + + 2022 + Dec + 15 + + + Dermatology online journal + Dermatol Online J + + A crack in the armor: Wolf isotopic response manifesting as cutaneous lupus. + 10.5070/D328659741 + + Wolf isotopic response represents the development of skin lesions of one particular morphology occurring at the same site as another morphologically distinct and unrelated skin lesion. Cutaneous lupus erythematosus (CLE) is an autoimmune connective tissue disorder encompassing a wide range of phenotypes that may be associated with systemic involvement. Although CLE is a well-described entity with a broad spectrum, the occurrence of lesions manifesting as an isotopic response is rare. We present a patient with systemic lupus erythematosus who developed CLE in a dermatomal distribution following herpes zoster. When CLE lesions present in a dermatomal distribution, these cases may be difficult to distinguish from recurrent herpes zoster infection in an immunosuppressed patient. Therefore, they pose a diagnostic challenge and require balancing antiviral therapy with immunosuppression to sufficiently maintain adequate control of the autoimmune disease while addressing possible infections. To avoid treatment delay, clinicians should have elevated suspicion for an isotopic response when disparate lesions erupt in areas previously affected by herpes zoster or in cases of persistent eruptions at sites of prior herpes zoster. We discuss this case within the context of Wolf isotopic response and review the literature for similar cases. + + + + Darsha + Adrija + A + + + Oldenburg + Reid + R + + + Hinds + Brian + B + + + Paravar + Taraneh + T + + Department of Dermatology, University of California San Diego, San Diego, California, USA. tparavar@health.ucsd.edu. + + + + eng + + Journal Article + + + 2022 + 12 + 15 + +
+ + United States + Dermatol Online J + 9610776 + 1087-2108 + + IM +
+ + + + 2022 + 12 + 27 + + + 2022 + 12 + 27 + + + 2023 + 2 + 22 + 13 + 32 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809096 + 10.5070/D328659741 + + +
+ + + 36809098 + + 2023 + 02 + 22 + +
+ + 1087-2108 + + 28 + 6 + + 2022 + Dec + 15 + + + Dermatology online journal + Dermatol Online J + + Bleeding complication following a shave biopsy in a patient taking ibrutinib. + 10.5070/D328659727 + + Ibrutinib is an oral Bruton tyrosine kinase inhibitor approved for use in patients with B-cell malignancies and has been shown to increase progression-free survival in patients with chronic lymphocytic leukemia (CLL). Ibrutinib is known to increase bleeding risk in patients with CLL. We report a patient with CLL on ibrutinib who experienced significant and prolonged bleeding after a routine superficial tangential shave biopsy for suspected squamous cell carcinoma. This prompted temporary cessation of this medication for the patient's subsequent Mohs surgery. This case demonstrates the possible severity of bleeding following routine dermatologic procedures. It is important to consider holding the medication prior to planned procedures such as dermatologic surgery. + + + + Esfandiari + Negar + N + + + Bombardier + Nathan + N + + + Pierson + Joseph C + JC + + The Larner College of Medicine, University of Vermont, Burlington, Vermont, USA Division of Dermatology, University of Vermont Medical Center, Burlington, Vermont, USA. Joseph.Pierson@uvmhealth.org. + + + + eng + + Journal Article + + + 2022 + 12 + 15 + +
+ + United States + Dermatol Online J + 9610776 + 1087-2108 + + IM +
+ + + + 2022 + 12 + 27 + + + 2022 + 12 + 27 + + + 2023 + 2 + 22 + 13 + 32 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809098 + 10.5070/D328659727 + + +
+ + + 36809115 + + 2023 + 02 + 22 + +
+ + 1096-4673 + + 44 + 2 + + 2023 + Feb + + + Issues in mental health nursing + Issues Ment Health Nurs + + Special Issue of Issues in Mental Health Nursing on the Topic of "The Future of Psychiatric-Mental Health Nursing". + + 92 + + 10.1080/01612840.2022.2158684 + eng + + Journal Article + +
+ + England + Issues Ment Health Nurs + 7907126 + 0161-2840 + +
+ + + + 2023 + 2 + 22 + 13 + 32 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809115 + 10.1080/01612840.2022.2158684 + + +
+ + + 36809099 + + 2023 + 02 + 22 + +
+ + 1087-2108 + + 28 + 6 + + 2022 + Dec + 15 + + + Dermatology online journal + Dermatol Online J + + Hemosiderotic (pigmented) atypical fibroxanthoma mimicking malignant melanoma. + 10.5070/D328659728 + + Atypical fibroxanthoma is a rare cutaneous malignancy that usually presents as a rapidly growing red papule on the head and neck in elderly white males. Several variants have been described. We report a patient who presented with a slowly enlarging pigmented lesion on his left ear that was clinically worrisome for malignant melanoma. Histopathologic evaluation with immunohistochemistry revealed an unusual case of hemosiderotic pigmented atypical fibroxanthoma. The tumor was successfully extirpated with Mohs micrographic surgery, with no recurrence at 6-month follow-up. + + + + Zhu + Tian Hao + TH + + + Painter + Collin + C + + + Hendrix + John D + JD + + Department of Dermatology, University of Virginia Health System, Charlottesville, Virginia, USA. dermsurgcv@mac.com. + + + + eng + + Journal Article + + + 2022 + 12 + 15 + +
+ + United States + Dermatol Online J + 9610776 + 1087-2108 + + IM +
+ + + + 2022 + 12 + 27 + + + 2022 + 12 + 27 + + + 2023 + 2 + 22 + 13 + 32 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809099 + 10.5070/D328659728 + + +
+ + + 36809102 + + 2023 + 02 + 22 + +
+ + 1087-2108 + + 28 + 6 + + 2022 + Dec + 15 + + + Dermatology online journal + Dermatol Online J + + Rapid and sustained response to apremilast in a patient with long-standing acrodermatitis continua of Hallopeau. + 10.5070/D328659731 + + + Fusta-Novell + Xavier + X + + Department of Dermatology, Althaia, Xarxa Assistencial Universitaria de Manresa, Manresa, Barcelona, Spain. + + + + Esquius + Mireia + M + + + Creus-Vila + Lidia + L + + + eng + + Journal Article + + + 2022 + 12 + 15 + +
+ + United States + Dermatol Online J + 9610776 + 1087-2108 + + IM +
+ + + + 2022 + 12 + 27 + + + 2022 + 12 + 27 + + + 2023 + 2 + 22 + 13 + 32 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809102 + 10.5070/D328659731 + + +
+ + + 36809110 + + 2023 + 02 + 22 + +
+ + 1557-8127 + + + 2023 + Feb + 21 + + + Assay and drug development technologies + Assay Drug Dev Technol + + Drug Repurposing Patent Applications October-December 2022. + 10.1089/adt.2023.008 + + + Mucke + Hermann A M + HAM + 0000-0002-1491-6250 + + H.M. Pharma Consultancy, Wien, Austria. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Assay Drug Dev Technol + 101151468 + 1540-658X + + IM +
+ + + + 2023 + 2 + 22 + 13 + 32 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809110 + 10.1089/adt.2023.008 + + +
+ + + 36809104 + + 2023 + 02 + 22 + +
+ + 1087-2108 + + 28 + 6 + + 2022 + Dec + 15 + + + Dermatology online journal + Dermatol Online J + + Chatbot utilization in dermatology: a potential amelioration to burnout in dermatology. + 10.5070/D328659734 + + + Diamond + Carrie + C + + School of Medicine, Duke University, Durham, North Carolina, USA. + + + + Rundle + Chandler W + CW + + + Albrecht + J Mark + JM + + + Nicholas + Matilda W + MW + + + eng + + Journal Article + + + 2022 + 12 + 15 + +
+ + United States + Dermatol Online J + 9610776 + 1087-2108 + + IM +
+ + + + 2022 + 12 + 27 + + + 2022 + 12 + 27 + + + 2023 + 2 + 22 + 13 + 32 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809104 + 10.5070/D328659734 + + +
+ + + 36809107 + + 2023 + 02 + 22 + +
+ + 1087-2108 + + 28 + 6 + + 2022 + Dec + 15 + + + Dermatology online journal + Dermatol Online J + + Perception of wig use in patients with hair loss. + 10.5070/D328659737 + + + Cook + Madison K + MK + + Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. + + + + Larrondo + Jorge + J + + + Feldman + Steven R + SR + + + McMichael + Amy J + AJ + + + eng + + Journal Article + + + 2022 + 12 + 15 + +
+ + United States + Dermatol Online J + 9610776 + 1087-2108 + + IM +
+ + + + 2022 + 12 + 27 + + + 2022 + 12 + 27 + + + 2023 + 2 + 22 + 13 + 32 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809107 + 10.5070/D328659737 + + +
+ + + 36809121 + + 2023 + 02 + 22 + +
+ + 1098-660X + + + 2023 + Feb + 21 + + + Journal of clinical microbiology + J Clin Microbiol + + Metagenomic Next-Generation Sequencing of Plasma for Diagnosis of COVID-19-Associated Pulmonary Aspergillosis. + + e0185922 + + 10.1128/jcm.01859-22 + + Timely diagnosis remains an unmet need in non-neutropenic patients at risk for aspergillosis, including those with COVID-19-associated pulmonary aspergillosis (CAPA), which in its early stages is characterized by tissue-invasive growth of the lungs with limited angioinvasion. Currently available mycological tests show limited sensitivity when testing blood specimens. Metagenomic next-generation sequencing (mNGS) to detect microbial cell-free DNA (mcfDNA) in plasma might overcome some of the limitations of conventional diagnostics. A two-center cohort study involving 114 COVID-19 intensive care unit patients evaluated the performance of plasma mcfDNA sequencing for the diagnosis of CAPA. Classification of CAPA was performed using the European Confederation for Medical Mycology (ECMM)/International Society for Human and Animal Mycoses (ISHAM) criteria. A total of 218 plasma samples were collected between April 2020 and June 2021 and tested for mcfDNA (Karius test). Only 6 patients were classified as probable CAPA, and 2 were classified as possible, while 106 patients did not fulfill CAPA criteria. The Karius test detected DNA of mold pathogens in 12 samples from 8 patients, including Aspergillus fumigatus in 10 samples from 6 patients. Mold pathogen DNA was detected in 5 of 6 (83% sensitivity) cases with probable CAPA (A. fumigatus in 8 samples from 4 patients and Rhizopus microsporus in 1 sample), while the test did not detect molds in 103 of 106 (97% specificity) cases without CAPA. The Karius test showed promising performance for diagnosis of CAPA when testing plasma, being highly specific. The test detected molds in all but one patient with probable CAPA, including cases where other mycological tests from blood resulted continuously negative, outlining the need for validation in larger studies. + + + + Hoenigl + Martin + M + 0000-0002-1653-2824 + + Division of Infectious Diseases, Excellence Center for Medical Mycology, Department of Internal Medicine, Medical University of Graz, Graz, Austria. + + + BioTechMed, Graz, Austria. + + + + Egger + Matthias + M + 0000-0002-7795-4406 + + Division of Infectious Diseases, Excellence Center for Medical Mycology, Department of Internal Medicine, Medical University of Graz, Graz, Austria. + + + BioTechMed, Graz, Austria. + + + + Price + Jessica + J + + Public Health Wales, Microbiology Cardiff, University Hospital of Wales, Cardiff, United Kingdom. + + + + Krause + Robert + R + + Division of Infectious Diseases, Excellence Center for Medical Mycology, Department of Internal Medicine, Medical University of Graz, Graz, Austria. + + + BioTechMed, Graz, Austria. + + + + Prattes + Juergen + J + + Division of Infectious Diseases, Excellence Center for Medical Mycology, Department of Internal Medicine, Medical University of Graz, Graz, Austria. + + + University of Cologne, Cologne, Germany. + + + University Hospital of Cologne, Department 1 for Internal Medicine, Infectious Diseases, Excellence Center for Medical Mycology, Cologne, Germany. + + + + White + P Lewis + PL + 0000-0003-3056-4205 + + Public Health Wales, Microbiology Cardiff, University Hospital of Wales, Cardiff, United Kingdom. + + + Division of Infection and Immunity, Center for Trials Research, Cardiff University, Cardiff, United Kingdom. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + J Clin Microbiol + 7505564 + 0095-1137 + + IM + + CAPA + COVID-19 + liquid biopsy + microbial cell-free DNA sequencing + +
+ + + + 2023 + 2 + 22 + 13 + 32 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809121 + 10.1128/jcm.01859-22 + + +
+ + + 36809120 + + 2023 + 02 + 22 + +
+ + 1476-8305 + + + 2023 + Feb + 21 + + + Nutritional neuroscience + Nutr Neurosci + + Triheptanoin, an odd-medium-chain triglyceride, impacts brain cognitive function in young and aged mice. + + 1-11 + + 10.1080/1028415X.2023.2178096 + + ABSTRACTThe brain aging process triggers cognitive function impairment, such as memory loss and compromised quality of life. Cognitive impairment is based on bioenergetic status, with reduced glucose uptake and metabolism in aged brains. Anaplerotic substrates are reported to promote mitochondrial ATP generation, having been tested in clinical trials for the treatment of neurological disorders and metabolic diseases.Objectives and Methods: To assess whether the improvement in oxidative capacity ameliorates cognitive function in adults (12 weeks), and aged (22-month-old) C57/6BJ mice, they received (1) a ketogenic diet, (2) a ketogenic diet supplemented with the anaplerotic substance, triheptanoin, or (3) a control diet for 12 weeks. Spontaneous alternation and time spent in a previously closed arm in the Y-maze test and time interacting with an unknown object in the novel object recognition test (NORT) were used to evaluate working memory. Acetylcholinesterase (AChE) activity in the prefrontal lobe, brain left hemisphere, and cerebellum was also evaluated. Glucose transporter 3 (GLUT3) expression in the prefrontal lobe was analyzed by western blotting.Results: The ketogenic diet (KD) reduced spontaneous alternation in aged mice, leading to lower AChE activity in the aged prefrontal lobe and cerebellum, and in the parieto-temporal-occipital lobe of adult mice. Furthermore, KD decreased GLUT3 protein expression in the frontal lobe of the adults.Discussion: Supplementation of KD with triheptanoin prevented memory impairment and showed similar values of AChE activity and GLUT3 expression compared to the controls. Our data suggest that triheptanoin has a potential role in the bioenergetic capacity of the brain, improving cognitive function. + + + + da Rocha + L S + LS + + Institute of Biological and Health Science, Federal University of Alagoas, Maceió, Brazil. + + + + Mendes + C B + CB + + Institute of Biological and Health Science, Federal University of Alagoas, Maceió, Brazil. + + + + Silva + J S + JS + + Institute of Biological and Health Science, Federal University of Alagoas, Maceió, Brazil. + + + + Alcides + R L G F + RLGF + + Institute of Biological and Health Science, Federal University of Alagoas, Maceió, Brazil. + + + + Mendonça + I P + IP + + Department of Physiology and Pharmacology, Federal University of Pernambuco, Recife, Brazil. + + + + Andrade-da-Costa + B L S + BLS + + Department of Physiology and Pharmacology, Federal University of Pernambuco, Recife, Brazil. + + + + Machado + S S + SS + + Chemistry and Biotechnology Institute, Federal University of Alagoas, Maceió, Brazil. + + + + Ximenes-da-Silva + A + A + 0000-0003-0422-4522 + + Institute of Biological and Health Science, Federal University of Alagoas, Maceió, Brazil. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Nutr Neurosci + 100892202 + 1028-415X + + IM + + Triheptanoin + aging + brain + ketogenic diet + memory + +
+ + + + 2023 + 2 + 22 + 13 + 32 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809120 + 10.1080/1028415X.2023.2178096 + + +
+ + + 36809113 + + 2023 + 02 + 22 + +
+ + 2150-7511 + + + 2023 + Feb + 21 + + + mBio + mBio + + Genome-Scale CRISPR Screening Reveals Host Factors Required for Ribosome Formation and Viral Replication. + + e0012723 + + 10.1128/mbio.00127-23 + + Viruses are known to co-opt host machinery for translation initiation, but less is known about which host factors are required for the formation of ribosomes used to synthesize viral proteins. Using a loss-of-function CRISPR screen, we show that synthesis of a flavivirus-encoded fluorescent reporter depends on multiple host factors, including several 60S ribosome biogenesis proteins. Viral phenotyping revealed that two of these factors, SBDS, a known ribosome biogenesis factor, and the relatively uncharacterized protein SPATA5, were broadly required for replication of flaviviruses, coronaviruses, alphaviruses, paramyxoviruses, an enterovirus, and a poxvirus. Mechanistic studies revealed that loss of SPATA5 caused defects in rRNA processing and ribosome assembly, suggesting that this human protein may be a functional ortholog of yeast Drg1. These studies implicate specific ribosome biogenesis proteins as viral host dependency factors that are required for synthesis of virally encoded protein and accordingly, optimal viral replication. IMPORTANCE Viruses are well known for their ability to co-opt host ribosomes to synthesize viral proteins. The specific factors involved in translation of viral RNAs are not fully described. In this study, we implemented a unique genome-scale CRISPR screen to identify previously uncharacterized host factors that are important for the synthesis of virally encoded protein. We found that multiple genes involved in 60S ribosome biogenesis were required for viral RNA translation. Loss of these factors severely impaired viral replication. Mechanistic studies on the AAA ATPase SPATA5 indicate that this host factor is required for a late step in ribosome formation. These findings reveal insight into the identity and function of specific ribosome biogenesis proteins that are critical for viral infections. + + + + Ohlson + Maikke B + MB + 0000-0002-1055-2269 + + Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA. + + + + Eitson + Jennifer L + JL + + Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA. + + + + Wells + Alexandra I + AI + + Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA. + + + + Kumar + Ashwani + A + + Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas, USA. + + + + Jang + Seoyeon + S + + Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA. + + + + Ni + Chunyang + C + + Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA. + + + + Xing + Chao + C + + Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas, USA. + + + Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, Texas, USA. + + + Department of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, Texas, USA. + + + + Buszczak + Michael + M + + Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA. + + + + Schoggins + John W + JW + 0000-0002-7944-6800 + + Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + mBio + 101519231 + + IM + + RNA virus + flavivirus + ribosomes + translation + virus-host interactions + +
+ + + + 2023 + 2 + 22 + 13 + 32 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809113 + 10.1128/mbio.00127-23 + + +
+ + + 36809112 + + 2023 + 02 + 22 + +
+ + 0250-832X + + + 2023 + Feb + 21 + + + Dento maxillo facial radiology + Dentomaxillofac Radiol + + MRI-based cephalometrics: A scoping review of current insights and future perspectives. + + 20230024 + + 10.1259/dmfr.20230024 + + This review aims to explore the current status of magnetic resonance imaging (MRI) as a cephalometric tool, summarize the equipment design and methods, and propose recommendations for future research. + A systematic search was conducted in electronic databases, including PubMed, Ovid MEDLINE, Scopus, Embase, Web of Science, EBSCOhost, LILACS, and Cochrane Library, using broad search terms. The articles published in any language till June 2022 were considered. Cephalometric studies conducted using the MRI dataset on human participants, phantom or cadaver were included. Two independent reviewers assessed the final eligible articles using the quality assessment score (QAS). + Nine studies were included in the final assessment. Studies used various methods, including 1.5 T or 3 T MRI systems and 3D or 2D MRI datasets. Among the imaging sequences, T1-weighted, T2-weighted and black bone MR images were used for cephalometric analysis. In addition, the reference standards varied among studies, such as traditional 2D cephalogram, cone-beam CT and phantom measurements. The mean QAS of all the included studies was 79% (± 14.4%). The main limitation of most studies was the small sample size and the heterogeneity of the methods, statistical tools used, and metric outcomes assessed. + Despite the heterogeneity and lack of metrological evidence on the effectiveness of MRI-based cephalometric analysis, the preliminary results demonstrated by in vivo and in vitro studies are encouraging. However, future studies exploring MRI sequences specific to cephalometric diagnosis are required for wider adoption of this technique in routine orthodontic practice. + + + + Sennimalai + Karthik + K + + Department of Orthodontics, All India Institute of Medical Sciences, Jammu 184120, Vijaypur, Jammu & Kashmir, India. + + + + Selvaraj + Madhanraj + M + + Consultant Orthodontist, PSG Institute of Management, Coimbatore 641005, Tamil Nadu, India. + + + + Kharbanda + Om Prakash + OP + + Pro Vice Chancellor- Health Sciences, Ramaiah University of Applied Sciences, Bengaluru 560054, Karnataka, India. + + + + Kandasamy + Devasenathipathy + D + + Department of Radiodiagnosis and Interventional Radiology, All India Institute of Medical Sciences, Ansari Nagar, Ansari Nagar 110029, New Delhi, India. + + + + Mohaideen + Kaja + K + + Department of Dentistry, All India Institute of Medical Sciences, Bilaspur 174001, Himachal Pradesh, India. + + + + eng + + Journal Article + Review + + + 2023 + 02 + 21 + +
+ + England + Dentomaxillofac Radiol + 7609576 + 0250-832X + + + cephalometry + diagnostic imaging + magnetic resonance imaging + nonionizing radiation + orthodontics + +
+ + + + 2023 + 2 + 22 + 13 + 32 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809112 + 10.1259/dmfr.20230024 + + +
+ + + 36809109 + + 2023 + 02 + 22 + +
+ + 2150-7511 + + + 2023 + Feb + 21 + + + mBio + mBio + + Ecological Stability Emerges at the Level of Strains in the Human Gut Microbiome. + + e0250222 + + 10.1128/mbio.02502-22 + + The human gut microbiome harbors substantial ecological diversity at the species level as well as at the strain level within species. In healthy hosts, species abundance fluctuations in the microbiome are thought to be stable, and these fluctuations can be described by macroecological laws. However, it is less clear how strain abundances change over time. An open question is whether individual strains behave like species themselves, exhibiting stability and following the macroecological relationships known to hold at the species level, or whether strains have different dynamics, perhaps due to the relatively close phylogenetic relatedness of cocolonizing lineages. Here, we analyze the daily dynamics of intraspecific genetic variation in the gut microbiomes of four healthy, densely longitudinally sampled hosts. First, we find that the overall genetic diversity of a large majority of species is stationary over time despite short-term fluctuations. Next, we show that fluctuations in abundances in approximately 80% of strains analyzed can be predicted with a stochastic logistic model (SLM), an ecological model of a population experiencing environmental fluctuations around a fixed carrying capacity, which has previously been shown to capture statistical properties of species abundance fluctuations. The success of this model indicates that strain abundances typically fluctuate around a fixed carrying capacity, suggesting that most strains are dynamically stable. Finally, we find that the strain abundances follow several empirical macroecological laws known to hold at the species level. Together, our results suggest that macroecological properties of the human gut microbiome, including its stability, emerge at the level of strains. IMPORTANCE To date, there has been an intense focus on the ecological dynamics of the human gut microbiome at the species level. However, there is considerable genetic diversity within species at the strain level, and these intraspecific differences can have important phenotypic effects on the host, impacting the ability to digest certain foods and metabolize drugs. Thus, to fully understand how the gut microbiome operates in times of health and sickness, its ecological dynamics may need to be quantified at the level of strains. Here, we show that a large majority of strains maintain stable abundances for periods of months to years, exhibiting fluctuations in abundance that can be well described by macroecological laws known to hold at the species level, while a smaller percentage of strains undergo rapid, directional changes in abundance. Overall, our work indicates that strains are an important unit of ecological organization in the human gut microbiome. + + + + Wolff + Richard + R + + Department of Ecology and Evolutionary Biology, UCLA, Los Angeles, California, USA. + + + + Shoemaker + William + W + 0000-0003-0111-4838 + + Department of Ecology and Evolutionary Biology, UCLA, Los Angeles, California, USA. + + + + Garud + Nandita + N + 0000-0003-4217-4407 + + Department of Ecology and Evolutionary Biology, UCLA, Los Angeles, California, USA. + + + Department of Human Genetics, UCLA, Los Angeles, California, USA. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + mBio + 101519231 + + IM + + ecology + human gut microbiome + macroecology + metagenomics + strains + +
+ + + + 2023 + 2 + 22 + 13 + 32 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809109 + 10.1128/mbio.02502-22 + + +
+ + + 36809118 + + 2023 + 02 + 22 + +
+ + 1559-8519 + + + 2023 + Feb + 21 + + + Journal of sex research + J Sex Res + + Fantasy Made Flesh - A Network Analysis of the Reciprocal Relationship between Sexual Fantasies, Pornography Usage, and Sexual Behavior. + + 1-15 + + 10.1080/00224499.2023.2170964 + + Based on different theories in media research (3AM, catalyst model of violent crime, reinforcing spirals model), we further explore the relationship between pornography use, sexual fantasy, and behavior. We suggest that pornography use appears so persistent across time and culture because it is related to a human universal, the ability to fantasize. Consequently, pornography use seems to be an opportunity to acquire media-mediated sexual fantasies, and we believe that pornography use interacts with sexual fantasies and, to a much weaker extent, with sexual behavior. To assess our assumptions, we conducted a network analysis with a large and diverse sample of N = 1338 hetero- and bisexual participants from Germany. Analyses were done separately for men and women. Our network analysis clustered parts of the psychological processes around the interaction of sexual fantasies, pornography use, and behavior into communities of especially strong interacting items. We detected meaningful communities (orgasm-centered intercourse, BDSM) consisting of sexual fantasies and behavior, with some containing pornography. However, pornography use was not part of communities we perceive to account for mainstream/everyday sexuality. Instead, our results show that non-mainstream behavior (e.g., BDSM) is affected by pornography use. Our study highlights the interaction between sexual fantasies, sexual behavior, and (parts of) pornography use. It advocates for a more interactionist view of human sexuality and media use. + + + + von Andrian-Werburg + Maximilian T P + MTP + 0000-0001-8713-8237 + + Institute Human-Computer-Media, Faculty of Human Sciences, University of Würzburg. + + + + Klopp + Eric + E + 0000-0002-6638-8912 + + Department of Education, Saarland University. + + + + Schwab + Frank + F + 0000-0001-5488-4321 + + Institute Human-Computer-Media, Faculty of Human Sciences, University of Würzburg. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + J Sex Res + 0062647 + 0022-4499 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 32 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809118 + 10.1080/00224499.2023.2170964 + + +
+ + + 36809124 + + 2023 + 02 + 22 + +
+ + 2165-0497 + + + 2023 + Feb + 21 + + + Microbiology spectrum + Microbiol Spectr + + Pharmacokinetics of Bictegravir in Older Japanese People Living with HIV-1. + + e0507922 + + 10.1128/spectrum.05079-22 + + Bictegravir (BIC) is an integrase strand transfer inhibitor widely used in the treatment of HIV-1. Although its potency and safety have been demonstrated in older patients, pharmacokinetics (PK) data remain limited in this patient population. Ten male patients aged 50 years or older with suppressed HIV RNA on other antiretroviral regimens were switched to a single-tablet regimen of BIC, emtricitabine, and tenofovir alafenamide (BIC+FTC+TAF). Four weeks later, plasma samples were collected at 9 time points for PK. Safety and efficacy were also assessed up to 48 weeks. The median age (range) of patients was 57.5 (50 to 75) years. Although 8 (80%) had lifestyle diseases requiring treatment, no participants had renal or liver failure. Nine (90%) were receiving dolutegravir-containing antiretroviral regimens at entry. The trough concentration of BIC was 2,324 (1,438 to 3,756) (geometric mean [95% confidence interval]) ng/mL, which was markedly above the 95% inhibitory concentration of the drug (162 ng/mL). All PK parameters, including area under the blood concentration-time curve and clearance, were similar to those in young HIV-negative Japanese participants in a previous study. No correlations between age and any PK parameters were observed in our study population. No participant experienced virological failure. Body weight, transaminase, renal function, lipid profiles, and bone mineral density were unchanged. Interestingly, urinary albumin was decreased after switching. PK of BIC was not affected by age, indicating that BIC+FTC+TAF may be safely used in older patients. IMPORTANCE BIC is a potent integrase strand transfer inhibitor (INSTI), widely used for the treatment of HIV-1 as part of a once-daily single-tablet regimen that includes emtricitabine and tenofovir alafenamide (BIC+FTC+TAF). Although the safety and efficacy of BIC+FTC+TAF have been confirmed in older patients with HIV-1, PK data in this patient population remain limited. Dolutegravir (DTG), an antiretroviral medication with a similar structural formula to BIC, causes neuropsychiatric adverse events. PK data for DTG have shown a higher maximum concentration (Cmax) among older patients than younger patients and are related to a higher frequency of adverse events. In the present study, we prospectively collected BIC PK data from 10 older HIV-1-infected patients and showed that PK of BIC are not affected by age. Our results support the safe use of this treatment regimen among older patients with HIV-1. + + + + Kawashima + Akira + A + + AIDS Clinical Center, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan. + + + + Trung + Hieu Tran + HT + + AIDS Clinical Center, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan. + + + The Joint Research Center for Human Retrovirus Infection Kumamoto University Campus, Kumamoto City, Kumamoto, Japan. + + + + Watanabe + Koji + K + 0000-0002-3190-8439 + + AIDS Clinical Center, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan. + + + + Takano + Misao + M + + AIDS Clinical Center, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan. + + + + Deguchi + Yoshimi + Y + + AIDS Clinical Center, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan. + + + + Kinoshita + Mai + M + + AIDS Clinical Center, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan. + + + + Uemura + Haruka + H + + AIDS Clinical Center, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan. + + + + Yanagawa + Yasuaki + Y + + AIDS Clinical Center, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan. + + + + Gatanaga + Hiroyuki + H + + AIDS Clinical Center, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan. + + + The Joint Research Center for Human Retrovirus Infection Kumamoto University Campus, Kumamoto City, Kumamoto, Japan. + + + + Kikuchi + Yoshimi + Y + + AIDS Clinical Center, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan. + + + + Oka + Shinichi + S + + AIDS Clinical Center, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan. + + + The Joint Research Center for Human Retrovirus Infection Kumamoto University Campus, Kumamoto City, Kumamoto, Japan. + + + + Tsuchiya + Kiyoto + K + + AIDS Clinical Center, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Microbiol Spectr + 101634614 + 2165-0497 + + IM + + Japanese + bictegravir + elderly + pharmacokinetics + +
+ + + + 2023 + 2 + 22 + 13 + 33 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809124 + 10.1128/spectrum.05079-22 + + +
+ + + 36809116 + + 2023 + 02 + 22 + +
+ + 1364-6915 + + + 2023 + Feb + 21 + + + Aging & mental health + Aging Ment Health + + Dimensionality and risk factors of the personal stigma of depression in adults aged 50 years and older at risk of depression. + + 1-8 + + 10.1080/13607863.2023.2179973 + + Objectives: Knowledge about the mechanism of the personal stigma of depression may inform strategies to reduce stigma and promote help-seeking. We examined the dimensionality and risk factors of the personal stigma of depression in older adults at risk of depression.Methods: Seven-hundred and one Hong Kong adults aged 50 years and older at risk of depression completed the personal stigma subscale of the depression Stigma Scale (DSS-personal) at two-time points. We used exploratory factor analysis (EFA) to explore the factor structure of DSS personal and confirmatory factor analysis to examine the model fit of the EFA-informed factor structure and structures proposed in previous studies. Regression analyses examined the relationships between risk factors and personal stigma dimensions.Results: Factor analyses identified a 3-factor structure of DSS-personal resembling the social-cognitive model consistent over time and included stereotype, prejudice, and discrimination (CFI = 0.95, TLI = 0.92, RMSEA = 0.05). Regression analyses indicated all stigma dimensions were associated with older age, less education, and no personal history of depression (B = -0.44 to 0.06); discrimination was also associated with more depressive symptoms (B = 0.10 to 0.12).Conclusion: Findings illustrated the potential theoretical underpinning of DSS-personal. Stigma reduction interventions could target and tailor to older adults with risk factors to enhance effectiveness and promote help-seeking. + + + + Leung + Dara Kiu Yi + DKY + 0000-0002-7255-2790 + + Department of Social Work and Social Administration, The University of Hong Kong, Hong Kong. + + + + Wong + Frankie Ho Chun + FHC + 0000-0001-9072-769X + + Department of Social Work and Social Administration, The University of Hong Kong, Hong Kong. + + + Philip Merrill College of Journalism, University of Maryland, College Park, USA. + + + + Yau + Jessie Ho-Yin + JH + 0000-0002-1673-3474 + + Department of Social Work and Social Administration, The University of Hong Kong, Hong Kong. + + + + Zhang + Anna Yan + AY + 0000-0001-8566-521X + + Department of Social Work and Social Administration, The University of Hong Kong, Hong Kong. + + + + Au + Walker Siu Hong + WSH + 0000-0002-9862-4457 + + Department of Social Work and Social Administration, The University of Hong Kong, Hong Kong. + + + + Liu + Tianyin + T + 0000-0002-8194-5342 + + Department of Social Work and Social Administration, The University of Hong Kong, Hong Kong. + + + + Wong + Gloria Hoi Yan + GHY + 0000-0002-1331-942X + + Department of Social Work and Social Administration, The University of Hong Kong, Hong Kong. + + + + Lum + Terry Yat Sang + TYS + 0000-0003-1196-5345 + + Department of Social Work and Social Administration, The University of Hong Kong, Hong Kong. + + + Sau Po Centre on Ageing, The University of Hong Kong, Hong Kong. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Aging Ment Health + 9705773 + 1360-7863 + + IM + + Stereotype + discrimination + prejudice + psychometrics + social-cognitive model + +
+ + + + 2023 + 2 + 22 + 13 + 32 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809116 + 10.1080/13607863.2023.2179973 + + +
+ + + 36809117 + + 2023 + 02 + 22 + +
+ + 2152-2723 + + 26 + 2 + + 2023 + Feb + + + Cyberpsychology, behavior and social networking + Cyberpsychol Behav Soc Netw + + The Effect of Previous Exposure on Virtual Reality Induced Public Speaking Anxiety: A Physiological and Behavioral Study. + + 127-133 + + 10.1089/cyber.2022.0121 + + Public speaking anxiety (PSA) is defined as a strong distress when performing a speech in front of an audience, causing impairment in terms of work possibilities and social relationships. Audience behavior and feedback received during a speech are a crucial variable to induce PSA, affecting performance and perception. In this study, two different virtual reality public speaking scenarios were developed to investigate the impact of positive (more assertive) versus negative (more hostile) audience behavior regarding perceived anxiety and physiological arousal during performance. Moreover, the presence of any carry-over effect based on first experiences (positive vs. negative) was investigated by using a within-between design. Both explicit (questionnaires) and implicit physiological measures (heart rate [HR]) were used to assess participants' experience. The results confirmed the influence of audience behavior on perceived anxiety. As expected, negative audience elicited greater anxiety and lower experience pleasantness. More interesting, the first experience influenced the perceived anxiety and arousal during performance, suggesting some sort of priming effect due to the valence of previous experience. In particular, starting with an encouraging feedback scenario did not increase the perceived anxiety and HR in front of a subsequent annoying audience. This modulation did not appear in the group who started with the annoying audience, which clearly reported higher HR and anxiety during the annoying exposure compared with the encouraging audience. These results are discussed considering previous evidence on the effect of feedback on performance. In addition, physiological results are interpreted considering the role of somatic marker theory in human performance. + + + + Girondini + Matteo + M + 0000-0003-4156-0779 + + Mind and Behavior Technological Center, University of Milano-Bicocca, Milano, Italy. + + + Department of Psychology, University of Milano-Bicocca, Milano, Italy. + + + + Stefanova + Milena + M + + Mind and Behavior Technological Center, University of Milano-Bicocca, Milano, Italy. + + + + Pillan + Margherita + M + + Department of Design, Politecnico di Milano, Milano, Italy. + + + + Gallace + Alberto + A + + Mind and Behavior Technological Center, University of Milano-Bicocca, Milano, Italy. + + + Department of Psychology, University of Milano-Bicocca, Milano, Italy. + + + + eng + + Journal Article + +
+ + United States + Cyberpsychol Behav Soc Netw + 101528721 + 2152-2715 + + IM + + audience behavior + physiological arousal + public speaking anxiety + virtual reality + +
+ + + + 2023 + 2 + 22 + 13 + 32 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809117 + 10.1089/cyber.2022.0121 + + +
+ + + 36809119 + + 2023 + 02 + 22 + +
+ + 2150-7511 + + + 2023 + Feb + 21 + + + mBio + mBio + + Of Murines and Humans: Modeling Persistent Powassan Disease in C57BL/6 Mice. + + e0360622 + + 10.1128/mbio.03606-22 + + Powassan infection is caused by two closely related, tick-transmitted viruses of the genus Flavivirus (family Flaviviridae): Powassan virus lineage I (POWV) and lineage II (known as deer tick virus [DTV]). Infection is typically asymptomatic or mild but can progress to neuroinvasive disease. Approximately 10% of neuroinvasive cases are fatal, and half of the survivors experience long-term neurological sequelae. Understanding how these viruses cause long-term symptoms as well as the possible role of viral persistence is important for developing therapies. We intraperitoneally inoculated 6-week-old C57BL/6 mice (50% female) with 103 focus-forming units (FFU) DTV and assayed for infectious virus, viral RNA, and inflammation during acute infection and 21, 56, and 84 days postinfection (dpi). Although most mice (86%) were viremic 3 dpi, only 21% of the mice were symptomatic and 83% recovered. Infectious virus was detected only in the brains of mice sampled during the acute infection. Viral RNA was detected in the brain until 84 dpi, but the magnitude decreased over time. Meningitis and encephalitis were visible in acute mice and from mice sampled at 21 dpi. Inflammation was observed until 56 dpi in the brain and 84 dpi in the spinal cord, albeit at low levels. These results suggest that the long-term neurological symptoms associated with Powassan disease are likely caused by lingering viral RNA and chronic inflammation in the central nervous system rather than by a persistent, active viral infection. The C57BL/6 model of persistent Powassan mimics illness in humans and can be used to study the mechanisms of chronic disease. IMPORTANCE Half of Powassan infection survivors experience long-term, mild to severe neurological symptoms. The progression from acute to chronic Powassan disease is not well understood, severely limiting treatment and prevention options. Infection of C57BL/6 mice with DTV mimics clinical disease in humans, and the mice exhibit CNS inflammation and viral RNA persistence until at least 86 dpi, while infectious virus is undetectable after 12 dpi. These findings suggest that the long-term neurological symptoms of chronic Powassan disease are in part due the persistence of viral RNA and the corresponding long-term inflammation of the brain and spinal cord. Our work demonstrates that C57BL/6 mice can be used to study the pathogenesis of chronic Powassan disease. + + + + Scroggs + Stacey L P + SLP + + Biology of Vector-Borne Viruses Section, Laboratory of Virology, Rocky Mountain Laboratories, Division of Intramural Research, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA. + + + Arthropod-Borne Animal Disease Research Unit, Center for Grain and Animal Health Research, Agricultural Research Service, United States Department of Agriculture, Manhattan, Kansas, USA. + + + + Offerdahl + Danielle K + DK + + Biology of Vector-Borne Viruses Section, Laboratory of Virology, Rocky Mountain Laboratories, Division of Intramural Research, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA. + + + + Stewart + Philip E + PE + + Biology of Vector-Borne Viruses Section, Laboratory of Virology, Rocky Mountain Laboratories, Division of Intramural Research, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA. + + + + Shaia + Carl + C + + Rocky Mountain Veterinary Branch, Rocky Mountain Laboratories, Division of Intramural Research, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA. + + + + Griffin + Amanda J + AJ + + Office of the Chief, Laboratory of Virology, Rocky Mountain Laboratories, Division of Intramural Research, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA. + + + + Bloom + Marshall E + ME + + Biology of Vector-Borne Viruses Section, Laboratory of Virology, Rocky Mountain Laboratories, Division of Intramural Research, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + mBio + 101519231 + + IM + + Powassan virus + animal model + chronic + deer tick virus + encephalitis + flavivirus + in vivo + inflammation + meningitis + mouse + tick-borne infection + +
+ + + + 2023 + 2 + 22 + 13 + 32 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809119 + 10.1128/mbio.03606-22 + + +
+ + + 36809122 + + 2023 + 02 + 22 + +
+ + 1949-1042 + + 14 + 1 + + 2023 + Dec + + + Nucleus (Austin, Tex.) + Nucleus + + The lamin A/C Ig-fold undergoes cell density-dependent changes that alter epitope binding. + + 2180206 + + 10.1080/19491034.2023.2180206 + + Lamins A/C are nuclear intermediate filament proteins that are involved in diverse cellular mechanical and biochemical functions. Here, we report that recognition of Lamins A/C by a commonly used antibody (JOL-2) that binds the Lamin A/C Ig-fold and other antibodies targeting similar epitopes is highly dependent on cell density, even though Lamin A/Clevels do not change. We propose that the effect is caused by partial unfolding or masking of the C'E and/or EF loops of the Ig-fold in response to cell spreading. Surprisingly, JOL-2 antibody labeling was insensitive to disruption of cytoskeletal filaments or the Linker of Nucleoskeleton and Cytoskeleton (LINC) complex. Furthermore, neither nuclear stiffness nor nucleo-cytoskeletal force transmission changed with cell density. These findings are important for the interpretation of immunofluorescence data for Lamin A/C and also raise the intriguing prospect that the conformational changes may play a role in Lamin A/C mediated cellular function. + + + + Wallace + Melanie + M + + Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA. + + + Weill Institute for Cell and Molecular Biology, Ithaca, NY, USA. + + + + Fedorchak + Gregory R + GR + + Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA. + + + Weill Institute for Cell and Molecular Biology, Ithaca, NY, USA. + + + + Agrawal + Richa + R + + Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA. + + + Weill Institute for Cell and Molecular Biology, Ithaca, NY, USA. + + + + Gilbert + Rachel M + RM + + Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA. + + + Weill Institute for Cell and Molecular Biology, Ithaca, NY, USA. + + + + Patel + Jineet + J + + Weill Institute for Cell and Molecular Biology, Ithaca, NY, USA. + + + + Park + Sangwoo + S + + Graduate Field of Biophysics, Cornell University, Ithaca, NY, USA. + + + + Paszek + Matthew + M + + Graduate Field of Biophysics, Cornell University, Ithaca, NY, USA. + + + Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, USA. + + + + Lammerding + Jan + J + + Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA. + + + Weill Institute for Cell and Molecular Biology, Ithaca, NY, USA. + + + + eng + + Journal Article + +
+ + United States + Nucleus + 101518322 + 1949-1034 + + IM + + Ig-fold + Lamins + cell density + cell spreading + immunofluorescence + immunolabeling + lamin A + lamin A/C + lamin C + mechanobiology + nuclear envelope + +
+ + + + 2023 + 2 + 22 + 13 + 32 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809122 + 10.1080/19491034.2023.2180206 + + +
+ + + 36809123 + + 2023 + 02 + 22 + +
+ + 2165-0497 + + + 2023 + Feb + 21 + + + Microbiology spectrum + Microbiol Spectr + + Multi-Omics Analysis Reveals the Resistance Mechanism and the Pathogens Causing Root Rot of Coptis chinensis. + + e0480322 + + 10.1128/spectrum.04803-22 + + Coptis chinensis is a traditional Chinese medicinal herb used for more than 2,000 years. Root rot in C. chinensis can cause brown discoloration (necrosis) in the fibrous roots and rhizomes, leading to plants wilting and dying. However, little information exists about the resistance mechanism and the potential pathogens of the root rot of C. chinensis plants. As a result, in order to investigate the relationship between the underlying molecular processes and the pathogenesis of root rot, transcriptome and microbiome analyses were performed on healthy and diseased C. chinensis rhizomes. This study found that root rot can lead to the significant reduction of medicinal components of Coptis, including thaliotrine, columbamine, epiberberin, coptisine, palmatine chloride, and berberine, affecting its efficacy quality. In the present study, Diaporthe eres, Fusarium avenaceum, and Fusarium solani were identified as the main pathogens causing root rot in C. chinensis. At the same time, the genes in phenylpropanoid biosynthesis, plant hormone signal transduction, plant-pathogen interaction, and alkaloid synthesis pathways were involved in the regulation of root rot resistance and medicinal component synthesis. In addition, harmful pathogens (D. eres, F. avenaceum and F. solani) also induce the expression of related genes in C. chinensis root tissues to reduce active medicinal ingredients. These results provide insights into the root rot tolerance study and pave the way for process disease resistance breeding and quality production of C. chinensis. IMPORTANCE Root rot disease significantly reduces the medicinal quality of Coptis chinensis. In the present study, results found that the C. chinensis fibrous and taproot have different tactics in response to rot pathogen infection. Diaporthe eres, Fusarium avenaceum, and Fusarium solani were isolated and identified to cause different degrees of C. chinensis root rot. These results are helpful for researchers to further explore the mechanism of resistance to rhizoma Coptis root rot. + + + + Song + Xuhong + X + 0000-0001-8596-8077 + + Chongqing Academy of Chinese Materia Medica, Chongqing, People's Republic of China. + + + + Mei + Pengying + P + + Chongqing Academy of Chinese Materia Medica, Chongqing, People's Republic of China. + + + + Dou + Tao + T + + Chongqing Academy of Chinese Materia Medica, Chongqing, People's Republic of China. + + + + Liu + Qundong + Q + + Chongqing Academy of Chinese Materia Medica, Chongqing, People's Republic of China. + + + + Li + Longyun + L + + Chongqing Academy of Chinese Materia Medica, Chongqing, People's Republic of China. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Microbiol Spectr + 101634614 + 2165-0497 + + IM + + Coptis chinensis + multi-omics + pathogen + resistance + root rot + +
+ + + + 2023 + 2 + 22 + 13 + 32 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809123 + 10.1128/spectrum.04803-22 + + +
+ + + 36809125 + + 2023 + 02 + 22 + +
+ + 1087-2108 + + 28 + 5 + + 2022 + Oct + 15 + + + Dermatology online journal + Dermatol Online J + + Efficacy of gabapentinoids for acute herpes zoster in preventing postherpetic neuralgia: a systematic review of randomized controlled trials. + 10.5070/D328559238 + + Gabapentinoids (e.g., gabapentin and pregabalin) have been established as a treatment for postherpetic neuralgia (PHN), but their effects on the prevention of PHN are unclear. This systematic review aimed to evaluate the efficacy of gabapentinoids for acute herpes zoster (HZ) in preventing PHN. PubMed, EMBASE, CENTRAL, and Web of Science were queried December 2020 to collect data on relevant randomized controlled trials (RCTs). A total of four RCTs (including 265 subjects) were retrieved. Overall, the incidence of PHN was lower, but not statistically significant in the gabapentinoid-treated group compared to the control group. Subjects treated with gabapentinoids were more likely to experience adverse events such as dizziness, somnolence, and gastrointestinal symptoms. This systematic review of RCTs showed that the addition of gabapentinoids during acute HZ are not significantly effective in preventing PHN. Nevertheless, the evidence on this subject remains limited. Physicians should carefully weigh the risks and benefits of prescribing gabapentinoids during the acute phase of HZ owing to its side effects. + + + + Menaldi + Sri Linuwih + SL + + Department of Dermatology and Venereology, Faculty of Medicine Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta, Indonesia. susetyo_mr@yahoo.com. + + + + Halim + Paulus Anthony + PA + + + Kurniawan + Kristian + K + + + eng + + Journal Article + + + 2022 + 10 + 15 + +
+ + United States + Dermatol Online J + 9610776 + 1087-2108 + + IM +
+ + + + 2022 + 10 + 19 + + + 2022 + 10 + 19 + + + 2023 + 2 + 22 + 13 + 33 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809125 + 10.5070/D328559238 + + +
+ + + 36809126 + + 2023 + 02 + 22 + +
+ + 1087-2108 + + 28 + 5 + + 2022 + Oct + 15 + + + Dermatology online journal + Dermatol Online J + + The use of oral vitamin A in acne management: a review. + 10.5070/D328559239 + + Changes to the iPLEDGE platform on December 13, 2021 made isotretinoin virtually inaccessible for many patients. Prior to the FDA approval of isotretinoin, a derivative of vitamin A, in 1982, vitamin A was used for severe acne. + To review the efficacy, safety, affordability, and practicality of vitamin A as a substitute for isotretinoin when the latter is inaccessible. + A literature review of PubMed was conducted using the key words: oral vitamin A, retinol, isotretinoin, Accutane, acne, iPLEDGE, hypervitaminosis A, and side effects. + We identified 9 studies (8 clinical trials and one case report); acne improved in 8 studies. Dosages ranged from 36,000IU daily to 500,000IU with 100,000IU as the most common. Mean duration until clinical improvement was 7 weeks to four months after initiation of therapy. Mucocutaneous side effects were most common, along with headaches, which resolved with either continued treatment or cessation. + Oral vitamin A is efficacious for the treatment of acne vulgaris, although the available studies have limited controls and outcomes. Side effects are qualitatively similar to those of isotretinoin and avoiding pregnancy for at least three months after stopping treatment is critical; like isotretinoin, vitamin A is a teratogen. + + + + Cook + Madison K + MK + + Department of Dermatology, Center for Dermatology Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. + + + + Perche + Patrick O + PO + + + Feldman + Steven R + SR + + + eng + + Journal Article + + + 2022 + 10 + 15 + +
+ + United States + Dermatol Online J + 9610776 + 1087-2108 + + IM +
+ + + + 2022 + 10 + 19 + + + 2022 + 10 + 19 + + + 2023 + 2 + 22 + 13 + 33 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809126 + 10.5070/D328559239 + + +
+ + + 36809130 + + 2023 + 02 + 22 + +
+ + 1087-2108 + + 28 + 5 + + 2022 + Oct + 15 + + + Dermatology online journal + Dermatol Online J + + Herpes manuum: a new name for non-digit herpetic whitlow. + 10.5070/D328559242 + + Herpes simplex virus (HSV) is one of the most prevalent infections worldwide. It consists of two types: HSV1 and HSV2 that primarily cause orofacial and genital disease. However, both types can infect any site. Rarely, HSV infection of the hand occurs and is often documented as herpetic whitlow. Herpetic whitlow is primarily recognized as an HSV infection of the digits and thus HSV infection of the hand is largely associated with infection of the fingers. This is problematic, as HSV is often left off the differential diagnosis of non-digit hand pathology. We present two cases of non-digit HSV infection of the hand that were misdiagnosed as bacterial infections. As our cases and others demonstrate, the lack of knowledge that HSV infections can occur on the hand leads to confusion and delayed diagnosis among a myriad of providers. Therefore, we seek to introduce the term "herpes manuum" to increase awareness that HSV can appear on the hand in locations aside from the digits and thus differentiate it from herpetic whitlow. By doing so, we hope to encourage more timely diagnosis of HSV hand infections to decrease associated morbidity. + + + + Miller + Austinn C + AC + + Center for Clinical Studies, Webster, Texas, USA. millerpublication@gmail.com. + + + + Jr + Alfredo Siller + AS + + + Adjei + Susuana + S + + + Temiz + Laurie A + LA + + + Tyring + Stephen K + SK + + + eng + + Journal Article + + + 2022 + 10 + 15 + +
+ + United States + Dermatol Online J + 9610776 + 1087-2108 + + IM +
+ + + + 2022 + 10 + 19 + + + 2022 + 10 + 19 + + + 2023 + 2 + 22 + 13 + 33 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809130 + 10.5070/D328559242 + + +
+ + + 36809145 + + 2023 + 02 + 22 + +
+ + 1087-2108 + + 28 + 5 + + 2022 + Oct + 15 + + + Dermatology online journal + Dermatol Online J + + Lichen planus related to COVID-19 vaccine: report of two cases. + 10.5070/D328559254 + + + Ceballos + Omar Al-Wattar + OA + + Department of Dermatology, Hospital General Universitario de Ciudad Real, Spain. omaralwattarmed@gmail.com. + + + + Rodriguez + Marcos Carmona + MC + + + Bolado + Fernando Moro + FM + + + Montalvo + Laura Martinez + LM + + + Garcia-Arpa + Monica + M + + + eng + + Journal Article + + + 2022 + 10 + 15 + +
+ + United States + Dermatol Online J + 9610776 + 1087-2108 + + IM +
+ + + + 2022 + 10 + 19 + + + 2022 + 10 + 19 + + + 2023 + 2 + 22 + 13 + 33 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809145 + 10.5070/D328559254 + + +
+ + + 36809127 + + 2023 + 02 + 22 + +
+ + 1087-2108 + + 28 + 5 + + 2022 + Oct + 15 + + + Dermatology online journal + Dermatol Online J + + Whole exome sequencing in a sample of Peruvian patients diagnosed with epidermolysis bullosa. + 10.5070/D328559240 + + Epidermolysis bullosa (EB) is a complex and heterogeneous dermatological disease. Four main types of EB have been described, each of them with distinct characteristics: EB simplex (EBS), dystrophic EB (DEB), junctional EB (JEB) and Kindler EB (KEB). Each main type varies in its manifestations, severity, and genetic abnormality. + We sought mutations in 19 genes known to cause EB and 10 genes associated with other dermatologic diseases in 35 Peruvian pediatric patients of a rich Amerindian genetic background. Whole exome sequencing and bioinformatics analysis was performed. + Thirty-four of 35 families revealed an EB mutation. Dystrophic EB was the most frequently diagnosed type, with 19 (56%) patients, followed by EBS (35%), JEB (6%), and KEB (3%). We found 37 mutations in seven genes; 27 (73%) were missense mutations; 22 (59%) were novel mutations. Five cases changed their initial diagnosis of EBS. Four were reclassified as DEB and one as JEB. Inspection into other non-EB genes revealed a variant, c.7130C&gt;A, in the gene FLGR2, which was present in 31 of the 34 patients (91%). + We were able to confirm and identify pathological mutations in 34 of 35 patients. + + + + Zevallos-Morales + Alejandro + A + + + Iberico + Rosario Torres + RT + + + Obispo + Daisy + D + + + Danos + Pierina + P + + + Sanchez + Rodrigo M + RM + + + Fujita + Ricardo + R + + + Guevara-Fujita + Maria L + ML + + Centro de Genetica y Biologia Molecular, Facultad de Medicina Humana, Universidad de San Martin de Porres. Lima, Peru. mguevarag@usmp.pe. + + + + eng + + Journal Article + + + 2022 + 10 + 15 + +
+ + United States + Dermatol Online J + 9610776 + 1087-2108 + + IM +
+ + + + 2022 + 10 + 19 + + + 2022 + 10 + 19 + + + 2023 + 2 + 22 + 13 + 33 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809127 + 10.5070/D328559240 + + +
+ + + 36809134 + + 2023 + 02 + 22 + +
+ + 1087-2108 + + 28 + 5 + + 2022 + Oct + 15 + + + Dermatology online journal + Dermatol Online J + + Questions raised by a case of adult-onset linear nodular scleroderma. + 10.5070/D328559245 + + Morphea presenting clinically with nodular or keloidal skin changes is extremely rare. Nodular scleroderma or keloidal morphea presenting in a linear distribution is even more uncommon. We present an otherwise healthy young woman with unilateral, linear, nodular scleroderma and review the somewhat confounding earlier literature in this area. To date, this young woman's skin changes have proven refractory to oral hydroxychloroquine and ultraviolet A1 phototherapy. Several aspects of this case including the patient's family history of Raynaud disease, her nodular sclerodermatous skin lesions, and the presence of U1RNP autoantibodies raised concern about her management with respect to future risk of developing systemic sclerosis. + + + + Marcelus + Christina + C + + + Jimenez + Amber + A + + + Zussman + Jamie + J + + + Hansen + Christopher B + CB + + + Sontheimer + Richard D + RD + + Department of Dermatology, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, Utah, USA. richard.sontheimer@hsc.utah.edu. + + + + eng + + Journal Article + + + 2022 + 10 + 15 + +
+ + United States + Dermatol Online J + 9610776 + 1087-2108 + + IM +
+ + + + 2022 + 10 + 19 + + + 2022 + 10 + 19 + + + 2023 + 2 + 22 + 13 + 33 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809134 + 10.5070/D328559245 + + +
+ + + 36809132 + + 2023 + 02 + 22 + +
+ + 1087-2108 + + 28 + 5 + + 2022 + Oct + 15 + + + Dermatology online journal + Dermatol Online J + + Multiple skin neoplasms at one site (MUSK IN A NEST): collision tumor consisting of epidermal (macular seborrheic keratosis) and dermal (lichen amyloidosis) components. + 10.5070/D328559259 + + A collision tumor is a neoplastic lesion comprised of two or more tumors consisting of distinct cell populations in the concurrent location. Multiple skin neoplasms at one site (MUSK IN A NEST) is a term recently coined to describe two or more cutaneous benign or malignant tumors occurring at the same anatomic site. In retrospective studies, seborrheic keratosis and cutaneous amyloidosis have both individually been documented as a component of a MUSK IN A NEST. This report describes a 42-year-old woman who presented with a pruritic skin condition on her arms and legs of 13 years' duration. Skin biopsy results showed epidermal hyperplasia with hyperkeratosis, hyperpigmentation of the basal layer with mild acanthosis, and evidence of amyloid deposition in the papillary dermis. Based on the clinical presentation and pathology findings, a concurrent diagnosis of macular seborrheic keratosis and lichen amyloidosis was established. A MUSK IN A NEST consisting of a macular seborrheic keratosis and lichen amyloidosis is likely a more common occurrence than implied by the paucity of published cases of this phenomenon. + + + + Laborada + Jennifer + J + + + Erickson + Christof P + CP + + + Calame + Antoanella + A + + + Cohen + Philip R + PR + + Department of Dermatology, University of California Davis Medical Center, Sacramento, CA; Touro University California College of Osteopathic Medicine, Vallejo, CA. mitehead@gmail.com. + + + + eng + + Journal Article + + + 2022 + 10 + 15 + +
+ + United States + Dermatol Online J + 9610776 + 1087-2108 + + IM +
+ + + + 2022 + 10 + 20 + + + 2022 + 10 + 20 + + + 2023 + 2 + 22 + 13 + 33 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809132 + 10.5070/D328559259 + + +
+ + + 36809140 + + 2023 + 02 + 22 + +
+ + 1087-2108 + + 28 + 5 + + 2022 + Oct + 15 + + + Dermatology online journal + Dermatol Online J + + A rare case of lues maligna in an HIV-negative woman. + 10.5070/D328559250 + + We describe an HIV-negative 43-year-old woman presenting with a diffuse ulceronodular eruption and positive serological tests for syphilis consistent with lues maligna. Lues maligna is a severe and rare variant of secondary syphilis characterized by prodromal constitutional symptoms followed by the formation of multiple well-circumscribed nodules with ulceration and crust. This case depicts a particularly rare presentation as lues maligna usually involves HIV-positive men. The clinical presentation of lues maligna can pose a diagnostic challenge, with infections, sarcoidosis, and cutaneous lymphoma as just a few entities in its broad differential diagnosis. However, with a high index of suspicion, clinicians can diagnose and treat this entity earlier and reduce morbidity. + + + + Nguyen + Christopher N + CN + + School of Medicine, Baylor College of Medicine, Texas, USA. christopher.nguyen42@gmail.com. + + + + Shaw + Fiona M + FM + + + Li + Monica M + MM + + + Blalock + Travis W + TW + + + eng + + Journal Article + + + 2022 + 10 + 15 + +
+ + United States + Dermatol Online J + 9610776 + 1087-2108 + + IM +
+ + + + 2022 + 10 + 19 + + + 2022 + 10 + 19 + + + 2023 + 2 + 22 + 13 + 33 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809140 + 10.5070/D328559250 + + +
+ + + 36809136 + + 2023 + 02 + 22 + +
+ + 1087-2108 + + 28 + 5 + + 2022 + Oct + 15 + + + Dermatology online journal + Dermatol Online J + + Treating linear porokeratosis with topical lovastatin/cholesterol cream. + 10.5070/D328559247 + + Linear porokeratosis is a rare variant of porokeratosis that is characterized by unilateral lesions along the lines of Blaschko. Like all variants of porokeratosis, linear porokeratosis is characterized by the histopathologic finding of cornoid lamellae bracketing the lesion. The underlying pathophysiology involves a two-hit post-zygotic knockdown of genes involved in mevalonate biosynthesis in embryonic keratinocytes. Although there is currently no standard or effective treatment, therapies targeted to rescue this pathway and restore keratinocyte cholesterol availability are promising. Presented here is a patient with a rare, extensive case of linear porokeratosis treated with compounded 2% lovastatin/2% cholesterol cream leading to partial resolution of the plaques. + + + + Buhle + Anna C + AC + + + Fagan + Kiley K + KK + + + Johnson + Nathan M + NM + + + Grider + Douglas J + DJ + + Section of Dermatology, Department of Internal Medicine, Virginia Tech Carilion School of Medicine, Roanoke, Virginia, USA Department of Basic Science Education, Virginia Tech Carilion School of Medicine, Roanoke, Virginia, USA. djgrider@carilionclinic.org. + + + + eng + + Journal Article + + + 2022 + 10 + 15 + +
+ + United States + Dermatol Online J + 9610776 + 1087-2108 + + IM +
+ + + + 2022 + 10 + 19 + + + 2022 + 10 + 19 + + + 2023 + 2 + 22 + 13 + 33 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809136 + 10.5070/D328559247 + + +
+ + + 36809138 + + 2023 + 02 + 22 + +
+ + 1087-2108 + + 28 + 5 + + 2022 + Oct + 15 + + + Dermatology online journal + Dermatol Online J + + Small lymphocytic lymphoma presenting as chronic diffuse lip swelling. + 10.5070/D328559249 + + Although rare, small lymphocytic lymphoma can present as chronic lip swelling and papules, thus mimicking the features of orofacial granulomatosis, a chronic inflammatory disorder characterized by subepithelial noncaseating granulomas, or papular mucinosis, characterized by localized dermal mucin deposition of mucin. When assessing lip swelling, one must carefully consider the clinical clues and have a low threshold to perform a diagnostic tissue biopsy, preventing delays in treatment or progression of the lymphoma. + + + + Yeh + Jennifer E + JE + + + Lorenzo + Mayra E + ME + + + Larocca + Cecilia + C + + + Fisher + David C + DC + + + Foreman + Ruth K + RK + + Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. rkforeman@partners.org,jeyeh@stanford.edu. + + + + eng + + Journal Article + + + 2022 + 10 + 15 + +
+ + United States + Dermatol Online J + 9610776 + 1087-2108 + + IM +
+ + + + 2022 + 10 + 19 + + + 2022 + 10 + 19 + + + 2023 + 2 + 22 + 13 + 33 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809138 + 10.5070/D328559249 + + +
+ + + 36809137 + + 2023 + 02 + 22 + +
+ + 1087-2108 + + 28 + 5 + + 2022 + Oct + 15 + + + Dermatology online journal + Dermatol Online J + + Telangiectasias of the breasts showing diffuse dermal angiomatosis in a patient with diffuse livedo reticularis. + 10.5070/D328559248 + + The breasts are a common location for diffuse dermal angiomatosis (DDA) in a context of obesity and macromastia. The typical clinical presentation includes erythematous or purplish plaques, reticulated telangiectasias, and sometimes livedo reticularis, often complicated by painful ulcerations of the breasts. Biopsy usually confirms a dermal proliferation of endothelial cells staining positively for CD31, CD34 and SMAa and negatively for HHV8. We report herein a woman with DDA of the breasts presenting as diffuse livedo reticularis and acrocyanosis, both long-standing and considered idiopathic following extensive investigations. Since a biopsy of the livedo did not document DDA features in our case, we suggest that our patient's livedo reticularis and telangiectasias could constitute a vascular predisposition for DDA, as its pathogenesis frequently involves an underlying disease involving ischemia, hypoxia, or hypercoagulability. + + + + Lemery + R + R + + Dermatology Department, University Hospital Centre Rennes, Rennes, France. Romain.LEMERY@chu-rennes.fr. + + + + Saillard + C + C + + + Le Gall + F + F + + + Bismut + M + M + + + Dupuy + A + A + + + eng + + Journal Article + + + 2022 + 10 + 15 + +
+ + United States + Dermatol Online J + 9610776 + 1087-2108 + + IM +
+ + + + 2022 + 10 + 19 + + + 2022 + 10 + 19 + + + 2023 + 2 + 22 + 13 + 33 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809137 + 10.5070/D328559248 + + +
+ + + 36809148 + + 2023 + 02 + 22 + +
+ + 2165-0497 + + + 2023 + Feb + 21 + + + Microbiology spectrum + Microbiol Spectr + + Antibodies to Nucleocapsid Are Not Diagnostic for Long COVID. + + e0490022 + + 10.1128/spectrum.04900-22 + + + Brandt + C T + CT + + Department of Infectious Diseases, Zealand University Hospital, University of Copenhagen, Roskilde, Denmark. + + + + Wiese + L + L + + Department of Infectious Diseases, Zealand University Hospital, University of Copenhagen, Roskilde, Denmark. + + + + Christiansen + K M + KM + + Department of Infectious Diseases, Odense University Hospital, Odense, Denmark. + + + + Agergaard + J + J + + Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark. + + + + eng + + Letter + + + 2023 + 02 + 21 + +
+ + United States + Microbiol Spectr + 101634614 + 2165-0497 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 33 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809148 + 10.1128/spectrum.04900-22 + + +
+ + + 36809141 + + 2023 + 02 + 22 + +
+ + 1087-2108 + + 28 + 5 + + 2022 + Oct + 15 + + + Dermatology online journal + Dermatol Online J + + Epidemiology of warts in U.S. adults: a survey study. + 10.5070/D328559251 + + + Perche + Patrick O + PO + + + Funk + Parker J + PJ + + + Cook + Madison K + MK + + + Hagen + Erin M + EM + + + Feldman + Steven R + SR + + Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA Department of Social Sciences &amp; Health Policy, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. sfeldman@wakehealth.edu. + + + + eng + + Journal Article + + + 2022 + 10 + 15 + +
+ + United States + Dermatol Online J + 9610776 + 1087-2108 + + IM +
+ + + + 2022 + 10 + 19 + + + 2022 + 10 + 19 + + + 2023 + 2 + 22 + 13 + 33 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809141 + 10.5070/D328559251 + + +
+ + + 36809129 + + 2023 + 02 + 22 + +
+ + 1087-2108 + + 28 + 5 + + 2022 + Oct + 15 + + + Dermatology online journal + Dermatol Online J + + Limited impact of teledermoscopy on referrals to face-to-face dermatology. + 10.5070/D328559241 + + Teledermoscopy improves teledermatology clinical outcomes, but the practical impact of this and other teleconsultation variables on patient management are unclear. We assessed the impact of these variables, including dermoscopy, on face-to-face (F2F) referrals to optimize effort by imagers and dermatologists. + Using retrospective chart review, we retrieved demographic, consultation, and outcome variables from 377 interfacility teleconsultations sent to San Francisco Veterans Affairs Health Care System (SFVAHCS) between September 2018 to March 2019 from another VA facility and its satellite clinics. Data were analyzed using descriptive statistics and logistic regression models. + Of 377 consults, 20 were excluded due to patient F2F self-referral without teledermatologist recommendation. Analysis of consults showed that age, clinical image, and problem number but not dermoscopy were associated with F2F referral. Analysis of problems contained in consults showed that lesion location and diagnostic category were also associated with F2F referral. Skin cancer history and problems on the head/neck were independently associated with skin growths in multivariate regression. + Teledermoscopy was associated with variables related to neoplasms but did not affect F2F referral rates. Rather than utilize teledermoscopy for all cases, our data suggests that referring sites prioritize teledermoscopy for consultations with variables associated with a likelihood of malignancy. + + + + Montejano + Rubi Danielle + RD + + + Oh + Dennis H + DH + + + Twigg + Amanda R + AR + + Department of Dermatology, University of California at San Francisco, San Francisco, California, USA Dermatology Research Unit, San Francisco VA Healthcare System, San Francisco, California, USA. amanda.twigg@ucsf.edu. + + + + eng + + Journal Article + + + 2022 + 10 + 15 + +
+ + United States + Dermatol Online J + 9610776 + 1087-2108 + + IM +
+ + + + 2022 + 10 + 19 + + + 2022 + 10 + 19 + + + 2023 + 2 + 22 + 13 + 33 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809129 + 10.5070/D328559241 + + +
+ + + 36809135 + + 2023 + 02 + 22 + +
+ + 1087-2108 + + 28 + 5 + + 2022 + Oct + 15 + + + Dermatology online journal + Dermatol Online J + + Leukocytoclastic vasculitis with features of flagellate purpura: a comparison with flagellate erythema. + 10.5070/D328559246 + + Leukocytoclastic vasculitis is a histopathologic term describing a type of small-vessel vasculitis characterized by a predominantly neutrophilic inflammatory infiltrate and nuclear debris. Skin involvement is common and can have a heterogeneous clinical presentation. Herein, we describe a 76-year-old woman with no history of chemotherapy or recent mushroom ingestion that presented with focal areas of flagellate purpura secondary to bacteremia. Histopathology revealed leukocytoclastic vasculitis and her rash resolved after antibiotic treatment. It is important to distinguish flagellate purpura from a similar condition, flagellate erythema, as they have been reported in association with distinct etiological and histopathological features. + + + + Ji-Xu + Antonio + A + + + Mansatta + Kushal + K + + + Bali + Radhika + R + + + Moezinia + Carine J + CJ + + University College London Centre for Rheumatology and Connective Tissue Diseases, Royal Free London NHS Foundation Trust, London, United Kingdom. cmoezinia@gmail.com. + + + + eng + + Journal Article + + + 2022 + 10 + 15 + +
+ + United States + Dermatol Online J + 9610776 + 1087-2108 + + IM +
+ + + + 2022 + 10 + 19 + + + 2022 + 10 + 19 + + + 2023 + 2 + 22 + 13 + 33 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809135 + 10.5070/D328559246 + + +
+ + + 36809128 + + 2023 + 02 + 22 + +
+ + 1087-2108 + + 28 + 5 + + 2022 + Oct + 15 + + + Dermatology online journal + Dermatol Online J + + Dermatology urgent care model reduces costs and healthcare utilization for psychodermatology patients - a retrospective chart review. + 10.5070/D328559260 + + Patients with psychiatric dermatoses may be high users of healthcare, especially emergency services. A dermatology urgent care model may reduce healthcare utilization in this population. + To determine whether a dermatology urgent care model can reduce healthcare utilization among patients with psychiatric dermatoses. + We conducted a retrospective chart review of patients seen in dermatology urgent care at Oregon Health and Science University between 2018 and 2020 with diagnoses of Morgellons disease and neurotic excoriations. Rates of diagnosis-related healthcare visits and emergency department visits were annualized before and during engagement with the dermatology department. Rates were compared using paired t-tests. + We found an 88.0% reduction in annual rates of healthcare visits (P&lt;0.001) and 77.0% reduction in emergency room visits (P&lt;0.003). Results were unchanged when controlled for gender identity, diagnosis, and substance use. + We could not account for healthcare use not included in electronic health record. + Urgent care models in dermatology may reduce overuse of healthcare and emergency services among patients with psychiatric dermatoses. + + + + Johnson + Jacob + J + + Department of Dermatology, Oregon Health and Science University, Center for Health and Healing, Oregon, USA. jpj2109@gmail.com. + + + + Cutler + Brett + B + + + Latour + Emile + E + + + Keller + Jesse J + JJ + + + eng + + Journal Article + + + 2022 + 10 + 15 + +
+ + United States + Dermatol Online J + 9610776 + 1087-2108 + + IM +
+ + + + 2022 + 10 + 20 + + + 2022 + 10 + 20 + + + 2023 + 2 + 22 + 13 + 33 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809128 + 10.5070/D328559260 + + +
+ + + 36809133 + + 2023 + 02 + 22 + +
+ + 1087-2108 + + 28 + 5 + + 2022 + Oct + 15 + + + Dermatology online journal + Dermatol Online J + + Cutaneous leukocytoclastic vasculitis after second dose of mRNA COVID-19 vaccine. + 10.5070/D328559244 + + Numerous cutaneous reactions following COVID-19 vaccination have already been described. Vasculitis, however, is a rare adverse event, occurring mainly after the first COVID-19 vaccination. Herein, we report a patient with IgA-positive cutaneous leukocytoclastic vasculitis, unresponsive to a moderate dose of systemic corticosteroid that erupted after the second dose of the Pfizer/BioNTech vaccine. Since booster vaccinations are being administered, we intend to raise awareness among clinicians and to highlight this potential reaction and its therapeutic approach. + + + + Simon + Sonja Cs + SC + + + Olsavszky + Victor + V + + Department of Dermatology, Venereology, and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology, Mannheim, Germany. victor.olsavszky@umm.de. + + + + eng + + Journal Article + + + 2022 + 10 + 15 + +
+ + United States + Dermatol Online J + 9610776 + 1087-2108 + + IM +
+ + + + 2022 + 10 + 19 + + + 2022 + 10 + 19 + + + 2023 + 2 + 22 + 13 + 33 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809133 + 10.5070/D328559244 + + +
+ + + 36809149 + + 2023 + 02 + 22 + +
+ + 1471-1753 + + + 2023 + Feb + 21 + + + The Journal of dermatological treatment + J Dermatolog Treat + + Exacerbation of psoriasis induced by lenalidomide in a patient with multiple myeloma. + + 1-3 + + 10.1080/09546634.2023.2182619 + + Lenalidomide is a relatively new targeted immunomodulatory drug, used for the treatment of multiple mieloma. We reported a case of a 54-year-old man with multiple mieloma, who developed psoriasis exacerbation concomitantly with lenalidomide treatment. We proposed to avoid discontinuation of the life-sparing agent and started topical treatment and phototherapy, finally achieving PASI 90. The mechanism by which these reactions occur is not fully understood, although an interaction between TNF-α and interferon alfa (IFN-α) has been suggested. To the best of our knowledge, this is the first reported case of psoriasis exacerbation by lenalidomide. + + + + Mioso + G + G + + Unit of Dermatology, Department of Medicine (DIMED), University of Padova, 35128 Padua Italy. + + + + Gnesotto + L + L + + Unit of Dermatology, Department of Medicine (DIMED), University of Padova, 35128 Padua Italy. + + + + Russo + I + I + + Unit of Dermatology, Department of Medicine (DIMED), University of Padova, 35128 Padua Italy. + + + Soft-Tissue, Peritoneum and Melanoma Surgical Oncology Unit, IOV- IRCCS, 35128 Padua, Italy. + + + + Piaserico + S + S + + Unit of Dermatology, Department of Medicine (DIMED), University of Padova, 35128 Padua Italy. + + + + Alaibac + M + M + + Unit of Dermatology, Department of Medicine (DIMED), University of Padova, 35128 Padua Italy. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + J Dermatolog Treat + 8918133 + 0954-6634 + + IM + + IFN-α + Lenalidomide + Multiple Myeloma + Psoriasis + TNF-α + +
+ + + + 2023 + 2 + 22 + 13 + 33 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809149 + 10.1080/09546634.2023.2182619 + + +
+ + + 36809131 + + 2023 + 02 + 22 + +
+ + 1087-2108 + + 28 + 5 + + 2022 + Oct + 15 + + + Dermatology online journal + Dermatol Online J + + Epidermolytic ichthyosis complicated by staphylococcal scalded skin syndrome in the newborn. + 10.5070/D328559243 + + Epidermolytic ichthyosis is characterized by erythema and blistering at birth. We present a neonate with epidermolytic ichthyosis who had a subtle change in clinical findings while hospitalized, including increased fussiness, erythema, and a change in her skin odor, which represented superimposed staphylococcal scalded skin syndrome. This case highlights the unique challenge of recognizing cutaneous infections in neonates with blistering skin disorders and emphasizes the importance of having a high suspicion for superinfection in this population. + + + + Peck + Gabrielle M + GM + + + Flood + Kelsey + K + + + Marathe + Kalyani + K + + Department of Dermatology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. Kalyani.Marathe@cchmc.org. + + + + eng + + Journal Article + + + 2022 + 10 + 15 + +
+ + United States + Dermatol Online J + 9610776 + 1087-2108 + + IM +
+ + + + 2022 + 10 + 19 + + + 2022 + 10 + 19 + + + 2023 + 2 + 22 + 13 + 33 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809131 + 10.5070/D328559243 + + +
+ + + 36809150 + + 2023 + 02 + 22 + +
+ + 1557-8992 + + + 2023 + Feb + 20 + + + Journal of child and adolescent psychopharmacology + J Child Adolesc Psychopharmacol + + Safety and Tolerability of Serdexmethylphenidate/Dexmethylphenidate Capsules in Children with Attention-Deficit/Hyperactivity Disorder: A 12-Month, Open-Label Safety Study. + 10.1089/cap.2022.0076 + + Objective: Serdexmethylphenidate/dexmethylphenidate (SDX/d-MPH) is approved for the treatment of patients aged ≥6 years with attention-deficit/hyperactivity disorder (ADHD). A pivotal double-blind (DB) study of children aged 6-12 years with ADHD demonstrated efficacy for ADHD with good tolerability. In this study, we assessed the safety and tolerability of daily oral SDX/d-MPH for up to 1 year in children with ADHD. Methods: This was a dose-optimized, open-label safety study with SDX/d-MPH in children aged 6-12 years with ADHD that included subjects who successfully completed the DB study (rollover) and new subjects. The study consisted of a 30-day screening phase, a dose optimization phase for new subjects only, a 360-day treatment phase, and follow-up. Adverse events (AEs) were assessed from the first day of SDX/d-MPH administration to the end of the study. During the treatment phase, ADHD Rating Scale-5 (ADHD-RS-5) and Clinical Global Impressions-Severity (CGI-S) scale assessments were used to evaluate ADHD severity. Results: Of the 282 subjects enrolled (70 rollover; 212 new), 28 discontinued treatment in the dose optimization phase and 254 entered the treatment phase. By study completion, 127 had discontinued and 155 had completed the study. The treatment-phase safety population included all enrolled subjects who received ≥1 dose of study drug and had ≥1 postdose safety assessment. Of 238 subjects assessed in the treatment-phase safety population, 143 (60.1%) had ≥1 treatment-emergent adverse events (TEAEs), and 36 (15.1%), 95 (39.9%), and 12 (5.0%) had mild, moderate, or severe TEAEs, respectively. The most common TEAEs were decreased appetite (18.5%), upper respiratory tract infection (9.7%), nasopharyngitis (8.0%), decreased weight (7.6%), and irritability (6.7%). There were no clinically meaningful trends in electrocardiograms, cardiac events, or blood pressure events, and none led to discontinuation. Two subjects had eight serious AEs that were unrelated to treatment. There were overall reductions in ADHD symptoms and severity as assessed by ADHD-RS-5 and CGI-S during the treatment phase. Conclusions: In this 1-year study, SDX/d-MPH was found to be safe and well tolerated and comparable with other methylphenidate products, with no unexpected safety findings. SDX/d-MPH also showed sustained efficacy during the 1-year treatment period. ClinicalTrials.gov identifier: NCT03460652. + + + + Childress + Ann C + AC + 0000-0001-5782-7891 + + Center for Psychiatry and Behavioral Medicine, Las Vegas, Nevada, USA. + + + + Marraffino + Andrea + A + + Accel Research Sites Network, Maitland, Florida, USA. + + + + Cutler + Andrew J + AJ + 0000-0001-5800-0378 + + SUNY Upstate Medical University, Syracuse, New York, USA. + + + Neuroscience Education Institute, Lakewood Ranch, Florida, USA. + + + + Oh + Charles + C + + Corium, LLC, Boston, Massachusetts, USA. + + + + Brams + Matthew N + MN + + Bayou City Research, Houston, Texas, USA. + + + + eng + + + ClinicalTrials.gov + + NCT03460652 + + + + + Journal Article + + + 2023 + 02 + 20 + +
+ + United States + J Child Adolesc Psychopharmacol + 9105358 + 1044-5463 + + IM + + ADHD-RS-5 + CGI-S + SDX/d-MPH + dexmethylphenidate + safety + serdexmethylphenidate + +
+ + + + 2023 + 2 + 22 + 13 + 33 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809150 + 10.1089/cap.2022.0076 + + +
+ + + 36809146 + + 2023 + 02 + 22 + +
+ + 1752-0371 + + + 2023 + Feb + 21 + + + Biomarkers in medicine + Biomark Med + + IL6R gene polymorphisms and their relation to chronic obstructive pulmonary disease susceptibility in the Chinese population. + 10.2217/bmm-2022-0342 + + Background: This work was designed to explore the correlation between IL6R polymorphisms and chronic obstructive pulmonary disease (COPD) susceptibility. Methods: Agena MassARRAY was used to genotype five SNPs of IL6R in 498 patients with COPD and 498 controls. Genetic models and haplotype analysis were used to assess the associations between SNPs and COPD risk. Results: Rs6689306 and rs4845625 increase the risk of COPD. Rs4537545, rs4129267 and rs2228145 were related to a decreased risk of COPD in different subgroups. Haplotype analysis revealed that GTCTC, GCCCA and GCTCA contributed to a reduced risk of COPD after adjustment. Conclusion: IL6R polymorphisms are significantly associated with COPD susceptibility. + + + + Wu + Haihong + H + 0000-0002-9397-1222 + + Department of General Practice, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, Hainan, 570311, China. + + + Department of Pulmonary & Critical Care Medicine, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, Hainan, 570311, China. + + + + He + Chanyi + C + 0000-0002-1058-2118 + + Department of General Practice, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, Hainan, 570311, China. + + + + Fu + Yihui + Y + 0000-0001-8790-8537 + + Department of General Practice, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, Hainan, 570311, China. + + + Department of Pulmonary & Critical Care Medicine, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, Hainan, 570311, China. + + + + Li + Xiukuan + X + 0000-0002-2753-6441 + + Department of General Practice, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, Hainan, 570311, China. + + + Meitai Health Center of Lingao County, Lingao, Hainan, 571824, China. + + + + Zheng + Yamei + Y + 0000-0002-9490-4961 + + Department of General Practice, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, Hainan, 570311, China. + + + Department of Pulmonary & Critical Care Medicine, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, Hainan, 570311, China. + + + + Mo + Rubing + R + 0000-0002-9922-2281 + + Department of General Practice, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, Hainan, 570311, China. + + + Department of Pulmonary & Critical Care Medicine, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, Hainan, 570311, China. + + + + Zhang + Lei + L + 0000-0002-9002-1731 + + Department of General Practice, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, Hainan, 570311, China. + + + Department of Pulmonary & Critical Care Medicine, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, Hainan, 570311, China. + + + + Zhao + Jie + J + 0000-0003-0941-7673 + + Department of General Practice, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, Hainan, 570311, China. + + + Department of Pulmonary & Critical Care Medicine, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, Hainan, 570311, China. + + + + Zhang + Bingli + B + 0000-0002-7507-806X + + Department of General Practice, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, Hainan, 570311, China. + + + Department of Pulmonary & Critical Care Medicine, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, Hainan, 570311, China. + + + + Lin + Qi + Q + 0000-0002-5864-3063 + + Department of General Practice, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, Hainan, 570311, China. + + + + Xie + Tian + T + 0000-0002-9422-6443 + + Department of General Practice, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, Hainan, 570311, China. + + + Department of Pulmonary & Critical Care Medicine, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, Hainan, 570311, China. + + + + Ding + Yipeng + Y + 0000-0002-5429-9939 + + Department of General Practice, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, Hainan, 570311, China. + + + Department of Pulmonary & Critical Care Medicine, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, Hainan, 570311, China. + + + + eng + + + 819QN354 + Hainan Provincial Natural Science Foundation of China + + + + 2018YFC2002304 + National Key Research and Development Program of China + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Biomark Med + 101312535 + 1752-0363 + + IM + + COPD + IL6R + case-control study + chronic obstructive pulmonary disease + polymorphisms + +
+ + + + 2023 + 2 + 22 + 13 + 33 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809146 + 10.2217/bmm-2022-0342 + + +
+ + + 36809139 + + 2023 + 02 + 22 + +
+ + 1087-2108 + + 28 + 5 + + 2022 + Oct + 15 + + + Dermatology online journal + Dermatol Online J + + Linear IgA bullous dermatosis of childhood. + 10.5070/D328559270 + + A 4-year-old boy presented with blistering on his face and distal upper and lower extremities. Subepidermal blisters containing neutrophils and eosinophils visualized on histology supported the diagnosis of linear IgA bullous dermatosis of childhood (LABDC). The dermatosis presents with vesicles and tense blisters in an annular distribution, erythematous papules, and/or excoriated plaques. Histopathology shows subepidermal blisters with a neutrophilic infiltrate in the dermis, mainly concentrated at the tips of dermal papillae in the early stage of the disease, which can be mistaken for the pattern of neutrophilic infiltration as seen in dermatitis herpetiformis. Dapsone is the treatment of choice, which is started at a dosage of 0.5mg/kg/day. Linear IgA bullous dermatosis of childhood is a rare autoimmune disease that can be mistaken for other conditions with similar presentations but should always be considered in the differential diagnosis of children with blistering. + + + + Nasri + Jasmin + J + + + Jungo + Pierre + P + + + Blickenstorfer + Marcel + M + + + Mühleisen + Beda + B + + + Navarini + Alexander A + AA + + + Juratli + Hazem A + HA + + + Lapides + Rebecca + R + + + Roider + Elisabeth + E + + Department of Dermatology, University Hospital Basel, Basel, Switzerland Kantonsspital Street Gallen und Universität Zurich, Street Gallen and Zurich, Schweiz, Switzerland. elisabeth.roider@usb.ch. + + + + eng + + Journal Article + + + 2022 + 10 + 15 + +
+ + United States + Dermatol Online J + 9610776 + 1087-2108 + + IM +
+ + + + 2022 + 10 + 22 + + + 2022 + 10 + 22 + + + 2023 + 2 + 22 + 13 + 33 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809139 + 10.5070/D328559270 + + +
+ + + 36809153 + + 2023 + 02 + 22 + +
+ + 2165-0497 + + + 2023 + Feb + 21 + + + Microbiology spectrum + Microbiol Spectr + + Synergy between Genome Mining, Metabolomics, and Bioinformatics Uncovers Antibacterial Chlorinated Carbazole Alkaloids and Their Biosynthetic Gene Cluster from Streptomyces tubbatahanensis sp. nov., a Novel Actinomycete Isolated from Sulu Sea, Philippines. + + e0366122 + + 10.1128/spectrum.03661-22 + + In this study, a novel actinomycete strain, DSD3025T, isolated from the underexplored marine sediments in Tubbataha Reefs Natural Park, Sulu Sea, Philippines, with the proposed name Streptomyces tubbatahanensis sp. nov., was described using polyphasic approaches and characterized using whole-genome sequencing. Its specialized metabolites were profiled using mass spectrometry and nuclear magnetic resonance analyses, followed by antibacterial, anticancer, and toxicity screening. The S. tubbatahanensis DSD3025T genome was comprised of 7.76 Mbp with a 72.3% G+C content. The average nucleotide identity and digital DNA-DNA hybridization values were 96.5% and 64.1%, respectively, compared with its closest related species, thus delineating the novelty of Streptomyces species. The genome encoded 29 putative biosynthetic gene clusters (BGCs), including a BGC region containing tryptophan halogenase and its associated flavin reductase, which were not found in its close Streptomyces relatives. The metabolite profiling unfolded six rare halogenated carbazole alkaloids, with chlocarbazomycin A as the major compound. A biosynthetic pathway for chlocarbazomycin A was proposed using genome mining, metabolomics, and bioinformatics platforms. Chlocarbazomycin A produced by S. tubbatahanensis DSD3025T has antibacterial activities against Staphylococcus aureus ATCC BAA-44 and Streptococcus pyogenes and showed antiproliferative activity against colon (HCT-116) and ovarian (A2780) human cancer cell lines. Chlocarbazomycin A exhibited no toxicity to liver cells but moderate and high toxicity to kidney and cardiac cell lines, respectively. IMPORTANCE Streptomyces tubbatahanensis DSD3025T is a novel actinomycete with antibiotic and anticancer activities from Tubbataha Reefs Natural Park, a United Nations Educational, Scientific and Cultural Organization World Heritage Site in Sulu Sea and considered one of the Philippines' oldest and most-well-protected marine ecosystems. In silico genome mining tools were used to identify putative BGCs that led to the discovery of genes involved in the production of halogenated carbazole alkaloids and new natural products. By integrating bioinformatics-driven genome mining and metabolomics, we unearthed the hidden biosynthetic richness and mined the associated chemical entities from the novel Streptomyces species. The bioprospecting of novel Streptomyces species from marine sediments of underexplored ecological niches serves as an important source of antibiotic and anticancer drug leads with unique chemical scaffolds. + + + + Tenebro + Chuckcris P + CP + + Center for Chemical Biology and Biotechnology, University of San Agustin, Iloilo City, Philippines. + + + + Trono + Dana Joanne V L + DJVL + + Center for Chemical Biology and Biotechnology, University of San Agustin, Iloilo City, Philippines. + + + + Balida + Lex Aliko P + LAP + + Center for Chemical Biology and Biotechnology, University of San Agustin, Iloilo City, Philippines. + + + + Bayog + Leah Katrine A + LKA + + Center for Chemical Biology and Biotechnology, University of San Agustin, Iloilo City, Philippines. + + + + Bruna + Julyanna R + JR + + Center for Chemical Biology and Biotechnology, University of San Agustin, Iloilo City, Philippines. + + + + Sabido + Edna M + EM + + Center for Chemical Biology and Biotechnology, University of San Agustin, Iloilo City, Philippines. + + + + Caspe + Dion Paul C + DPC + + Center for Natural Drug Discovery and Development, University of San Agustin, Iloilo City, Philippines. + + + + de Los Santos + Emmanuel Lorenzo C + ELC + + Research Analytics, Early Solutions Data & Translational Services, UCB Celltech, Slough, Berkshire, United Kingdom. + + + Balik Scientist Program, Department of Science and Technology, Philippine Council for Health Research and Development, Bicutan, Taguig City, Philippines. + + + + Saludes + Jonel P + JP + 0000-0001-9536-5982 + + Center for Natural Drug Discovery and Development, University of San Agustin, Iloilo City, Philippines. + + + Balik Scientist Program, Department of Science and Technology, Philippine Council for Health Research and Development, Bicutan, Taguig City, Philippines. + + + Department of Chemistry, College of Liberal Arts, Sciences, and Education, University of San Agustin, Iloilo City, Philippines. + + + + Dalisay + Doralyn S + DS + 0000-0003-2850-7797 + + Center for Chemical Biology and Biotechnology, University of San Agustin, Iloilo City, Philippines. + + + Balik Scientist Program, Department of Science and Technology, Philippine Council for Health Research and Development, Bicutan, Taguig City, Philippines. + + + Department of Biology, College of Liberal Arts, Sciences, and Education, University of San Agustin, Iloilo City, Philippines. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Microbiol Spectr + 101634614 + 2165-0497 + + IM + + Streptomyces + antibiotic + anticancer + biosynthetic gene clusters + flavin reductase + halogenated carbazole alkaloids + specialized metabolites + tryptophan halogenase + +
+ + + + 2023 + 2 + 22 + 13 + 33 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809153 + 10.1128/spectrum.03661-22 + + +
+ + + 36809144 + + 2023 + 02 + 22 + +
+ + 1087-2108 + + 28 + 5 + + 2022 + Oct + 15 + + + Dermatology online journal + Dermatol Online J + + A virtual dermatology elective for underrepresented in medicine medical students. + 10.5070/D328559253 + + + Chopra + Shara + S + + Penn State College of Medicine, Hershey, Pennsylvania, USA. + + + + Simmers + Jocelyn + J + + + Kirby + Joslyn + J + + + Flamm + Alexandra + A + + + eng + + Journal Article + + + 2022 + 10 + 15 + +
+ + United States + Dermatol Online J + 9610776 + 1087-2108 + + IM +
+ + + + 2022 + 10 + 19 + + + 2022 + 10 + 19 + + + 2023 + 2 + 22 + 13 + 33 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809144 + 10.5070/D328559253 + + +
+ + + 36809154 + + 2023 + 02 + 22 + +
+ + 1741-2684 + + + 2023 + Feb + 21 + + + Dementia (London, England) + Dementia (London) + + Living with dementia: Why I am thinking of 'death'. + + 14713012231158859 + + 10.1177/14713012231158859 + + Dementia is recognized globally as a massive burden on public health and wider society. It is a major cause of disability and mortality amongst older people. China has the largest population of people with dementia worldwide, accounting for approximately 25% of the entire global population of people with dementia. The study investigated the perceived experiences of care giving and care receiving in China, with one area identified in the data concerning the extent to which the participants discussed death. The research also explored the meaning of living with dementia in modern China, where the economy, demography and culture are rapidly changing. + The qualitative approach of interpretative phenomenological analysis was used for this study. Semi-structured interviews were used for data collection. + The paper reports on one specific finding concerning death as a way out of the situation that participants found themselves in. + The study described and interpreted one of the specific issues, 'death', in the participants' narratives. This finding reflects how psychological and social factors, such as stress, social support, healthcare cost, caring burden and medical practice have created the participants' thoughts of 'wishing to die' and the reasons why they believe 'death is a way to reduce burden'. It calls for an understanding, supportive social environment and a reconsideration of a culturally and economically appropriate family-based care system. + + + + Zhang + Xiubin + X + 0000-0003-2660-3937 + + National Heart and Lung Institute, 4615Imperial College London, London, UK. + + + + Clarke + Charlotte + C + 0000-0001-5263-5719 + + Social Sciences & Health, 3057Durham University, Durham, UK. + + + + Ding + Rong + R + + School of Heath in Social Science, The University of Edinburgh, Edinburgh, UK. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Dementia (London) + 101128698 + 1471-3012 + + IM + + China + death + dementia + interpretative phenomenological analysis + +
+ + + + 2023 + 2 + 22 + 13 + 33 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809154 + 10.1177/14713012231158859 + + +
+ + + 36809143 + + 2023 + 02 + 22 + +
+ + 1087-2108 + + 28 + 5 + + 2022 + Oct + 15 + + + Dermatology online journal + Dermatol Online J + + Pathological complete response to preoperative avelumab treatment in a patient with advanced Merkel cell carcinoma. + 10.5070/D328559252 + + + Mizuta + Haruki + H + + + Ogata + Dai + D + + Department of Dermatologic Oncology, National Cancer Center Hospital, Tokyo, Japan. dogata@ncc.go.jp. + + + + Jinnai + Shunichi + S + + + Namikawa + Kenjiro + K + + + Takahashi + Akira + A + + + Yamazaki + Naoya + N + + + eng + + Journal Article + + + 2022 + 10 + 15 + +
+ + United States + Dermatol Online J + 9610776 + 1087-2108 + + IM +
+ + + + 2022 + 10 + 19 + + + 2022 + 10 + 19 + + + 2023 + 2 + 22 + 13 + 33 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809143 + 10.5070/D328559252 + + +
+ + + 36809142 + + 2023 + 02 + 22 + +
+ + 1087-2108 + + 28 + 5 + + 2022 + Oct + 15 + + + Dermatology online journal + Dermatol Online J + + Acute localized pustular drug reaction to pembrolizumab. + 10.5070/D328559261 + + + Pineiro + Alexandra + A + + + Effle + Kaitlin E + KE + + + Abraham + Akhil + A + + + Cockerell + Clay J + CJ + + + Shanler + Stuart D + SD + + + Ondo + Andrew L + AL + + School of Medicine, University of New Mexico, Albuquerque, New Mexico. andyondo@yahoo.com. + + + + eng + + Journal Article + + + 2022 + 10 + 15 + +
+ + United States + Dermatol Online J + 9610776 + 1087-2108 + + IM +
+ + + + 2022 + 10 + 20 + + + 2022 + 10 + 20 + + + 2023 + 2 + 22 + 13 + 33 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809142 + 10.5070/D328559261 + + +
+ + + 36809151 + + 2023 + 02 + 22 + +
+ + 1748-880X + + + 2023 + Feb + 21 + + + The British journal of radiology + Br J Radiol + + The added value of brain MR spectroscopy in children with Crigler-Najjar syndrome Type-I: Correlation with demographic, neurodevelopmental, and laboratory findings. + + 20220433 + + 10.1259/bjr.20220433 + + The aim of this study is to demonstrate the role of proton magnetic resonance spectroscopy (1H-MRS) in the detection of brain microstructural changes in patients with Crigler-Najjar Syndrome type-I (CNs-I), and its correlation with demographic, neurodevelopmental and laboratory findings. + Prospective study was conducted on 25 children with CNs-I and 25 age and sex-matched children, who served as control. They underwent multivoxel 1H-MRS of basal ganglion at TE 135-144 ms. NAA/Cr and Ch/Cr were calculated and correlated with demographic, clinical, and laboratory findings of patients with CNs-I. + There was a significant difference in NAA/Cr and Ch/Cr between patients and controls. The cut-off value for NAA/Cr and Ch/Cr used to differentiate patients from controls were 1.8 and 1.2 with an area under the curve (AUC) of 0.91 and 0.84 respectively. There was a significant difference in MRS ratios between patients with neurodevelopmental delay (NDD) and patients without NDD. The cut-off values for NAA/Cr and Ch/Cr used to differentiate between patients with NDD and patients without NDD were 1.47 and 0.99, with AUC of 0.87 and 0.8 respectively. The NAA/Cr and Ch/Cr were well correlated with family history (p = 0.006 and p < 0.001) respectively, consanguinity (p < 0.001 and p = 0.001), neurodevelopmental delay (p = 0.001 and p = 0.004), serum bilirubin level (r = -0.77, p < 0.001), (r = -0.49, p = 0.014), phototherapy (p < 0.001 and p = 0.32), blood transfusion (p < 0.001 and p = 0.001) respectively. + 1H-MRS can be a useful tool in the detection of neurological changes in patients with CNs-I; NAA/Cr and Ch/Cr parameters are well correlated with demographic, clinical, and laboratory findings. + our study is the first report on using MRS in assessing neurological manifestations in CNs. 1H-MRS can be a useful tool in the detection of neurological changes in patients with CNs-I. + + + + Alnaghy + Eman + E + 0000-0003-0032-434X + + Radiology Department. Faculty of Medicine. Mansoura University, Mansoura, Egypt. + + + + Taman + Saher + S + + Radiology Department. Faculty of Medicine. Mansoura University, Mansoura, Egypt. + + + + Abdelhalim + Ebrahim + E + + Department of General surgery, Faculty of Medicine, Horus University, Damietta, Egypt. + + + + Abdel Razek + Ahmed + A + + Radiology Department. Faculty of Medicine. Mansoura University, Mansoura, Egypt. + + + + El-Shabrawi + Mortada + M + + Faculty of Medicine. Cairo university, Giza, Egypt. + + + + Ezz El Regal + Mohamed + M + + Children hospital. Faculty of Medicine. Mansoura University, Mansoura, Egypt. + + + + Megahed + Ahmed + A + + Children hospital. Faculty of Medicine. Mansoura University, Mansoura, Egypt. + + + + Elzeny + Sherine + S + + Children hospital. Faculty of Medicine. Mansoura University, Mansoura, Egypt. + + + + El Tantawi + Noha + N + + Children hospital. Faculty of Medicine. Mansoura University, Mansoura, Egypt. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Br J Radiol + 0373125 + 0007-1285 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 33 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809151 + 10.1259/bjr.20220433 + + +
+ + + 36809147 + + 2023 + 02 + 22 + +
+ + 1471-1753 + + + 2023 + Feb + 21 + + + The Journal of dermatological treatment + J Dermatolog Treat + + Development of a new classification and scoring system for scalp conditions: Scalp Photographic Index (SPI). + + 1-10 + + 10.1080/09546634.2023.2181655 + + There has been no validated tool for objectively quantifying the overall condition and characteristics of the scalp. This study aimed to establish and validate a new classification and scoring system for evaluating scalp conditions. + The Scalp Photographic Index (SPI) using a trichoscope grades 5 features of scalp conditions (Dryness, Oiliness, Erythema, Folliculitis, and Dandruff) on a score of 0 to 3. To evaluate the validity of SPI, SPI grading was performed by 3 experts on the scalps of 100 subjects along with a dermatologist's assessment of the scalps and a scalp-related symptom survey. For reliability assessment, 20 healthcare providers performed SPI grading for the 95 selected photographs of the scalp. + SPI grading and the dermatologist's scalp assessment showed good correlations for all five scalp features. Warmth showed a significant correlation with all features of SPI and the subjects' perception of a scalp pimple had a significant positive correlation with the folliculitis feature. SPI grading demonstrated good reliability with excellent internal consistency (Cronbach's α = 0.90) and strong inter- and intra-rater reliability (Kendall's W = 0.84, ICC(3,1) = 0.94). + SPI is an objective, reproducible, and validated numeric system for classifying and scoring scalp conditions. + + + + Kim + Bo Ri + BR + 0000-0002-2223-1606 + + Department of Dermatology, Seoul National University Bundang Hospital, Seongnam, Korea. + + + + Won + Seung Hyun + SH + + Medical Research Collaborating Center, Seoul National University Bundang Hospital, Seongnam, Korea. + + + + Kim + Jee Woo + JW + 0000-0003-1618-7327 + + Department of Dermatology, Seoul National University Bundang Hospital, Seongnam, Korea. + + + Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea. + + + + Kim + Minjae + M + + Department of Dermatology, Seoul National University Bundang Hospital, Seongnam, Korea. + + + Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea. + + + + Jeong + Jeong-Il + JI + + Aram Huvis Co., Ltd., Seongnam, Korea. + + + + Shin + Jung-Won + JW + + Department of Dermatology, Seoul National University Bundang Hospital, Seongnam, Korea. + + + Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea. + + + + Huh + Chang-Hun + CH + + Department of Dermatology, Seoul National University Bundang Hospital, Seongnam, Korea. + + + Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea. + + + + Na + Jung-Im + JI + + Department of Dermatology, Seoul National University Bundang Hospital, Seongnam, Korea. + + + Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + J Dermatolog Treat + 8918133 + 0954-6634 + + IM + + clinical dermatology + common skin diseases + diagnosis + hair disorders + +
+ + + + 2023 + 2 + 22 + 13 + 33 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809147 + 10.1080/09546634.2023.2181655 + + +
+ + + 36809155 + + 2023 + 02 + 22 + +
+ + 1944-0057 + + + 2023 + Feb + 21 + + + Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment + Food Addit Contam Part A Chem Anal Control Expo Risk Assess + + Correction. + + 1 + + 10.1080/19440049.2022.2160593 + eng + + Published Erratum + + + 2023 + 02 + 21 + +
+ + England + Food Addit Contam Part A Chem Anal Control Expo Risk Assess + 101485040 + 1944-0057 + + IM + + + Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2021 Feb;38(2):208-222 + 33451265 + + +
+ + + + 2023 + 2 + 22 + 13 + 33 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809155 + 10.1080/19440049.2022.2160593 + + +
+ + + 36809156 + + 2023 + 02 + 22 + +
+ + 2190-5142 + + 69 + 6 + + 2022 + Nov + + + Experimental psychology + Exp Psychol + + List of Reviewers 2022. + + 354 + + 10.1027/1618-3169/a000573 + eng + + Journal Article + +
+ + Germany + Exp Psychol + 101138477 + 1618-3169 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 33 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809156 + 10.1027/1618-3169/a000573 + + +
+ + + 36809152 + + 2023 + 02 + 22 + +
+ + 2165-0497 + + + 2023 + Feb + 21 + + + Microbiology spectrum + Microbiol Spectr + + New Insights into the Bacterial Targets of Antimicrobial Blue Light. + + e0283322 + + 10.1128/spectrum.02833-22 + + Antimicrobial blue light (aBL) offers efficacy and safety in treating infections. However, the bacterial targets for aBL are still poorly understood and may be dependent on bacterial species. Here, we investigated the biological targets of bacterial killing by aBL (λ = 410 nm) on three pathogens: Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. Initially, we evaluated the killing kinetics of bacteria exposed to aBL and used this information to calculate the lethal doses (LD) responsible for killing 90 and 99.9% of bacteria. We also quantified endogenous porphyrins and assessed their spatial distribution. We then quantified and suppressed reactive oxygen species (ROS) production in bacteria to investigate their role in bacterial killing by aBL. We also assessed aBL-induced DNA damage, protein carbonylation, lipid peroxidation, and membrane permeability in bacteria. Our data showed that P. aeruginosa was more susceptible to aBL (LD99.9 = 54.7 J/cm2) relative to S. aureus (LD99.9 = 158.9 J/cm2) and E. coli (LD99.9 = 195 J/cm2). P. aeruginosa exhibited the highest concentration of endogenous porphyrins and level of ROS production relative to the other species. However, unlike other species, DNA degradation was not observed in P. aeruginosa. Sublethal doses of blue light (<LD90) could damage the cell membrane in Gram-negative species but not in S. aureus. In all bacteria, oxidative damage to bacterial DNA (except P. aeruginosa), proteins, and lipids occurred after high aBL exposures (>LD99.9). We conclude that the primary targets of aBL depend on the species, which are probably driven by variable antioxidant and DNA-repair mechanisms. IMPORTANCE Antimicrobial-drug development is facing increased scrutiny following the worldwide antibiotic crisis. Scientists across the world have recognized the urgent need for new antimicrobial therapies. In this sense, antimicrobial blue light (aBL) is a promising option due to its antimicrobial properties. Although aBL can damage different cell structures, the targets responsible for bacterial inactivation have still not been completely established and require further exploration. In our study, we conducted a thorough investigation to identify the possible aBL targets and gain insights into the bactericidal effects of aBL on three relevant pathogens: Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. This research not only adds new content to blue light studies but opens new perspectives to antimicrobial applications. + + + + Dos Anjos + Carolina + C + 0000-0001-5725-8852 + + Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. + + + Department of Internal Medicine, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil. + + + + Leanse + Leon G + LG + + Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. + + + University of Gibraltar, Europa Point Campus, Gibraltar. + + + + Ribeiro + Martha S + MS + + Center for Lasers and Applications, Nuclear and Energy Research Institute (IPEN-CNEN), São Paulo, Brazil. + + + + Sellera + Fábio P + FP + + Department of Internal Medicine, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil. + + + School of Veterinary Medicine, Metropolitan University of Santos, Santos, Brazil. + + + + Dropa + Milena + M + + MicroRes Laboratory, School of Public Health, University of São Paulo, São Paulo, Brazil. + + + + Arana-Chavez + Victor E + VE + + Department of Biomaterials and Oral Biology, University of São Paulo, São Paulo, Brazil. + + + + Lincopan + Nilton + N + 0000-0003-0161-5800 + + Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil. + + + Department of Microbiology, Institute for Biomedical Sciences, University of São Paulo, São Paulo, Brazil. + + + + Baptista + Maurício S + MS + + Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil. + + + + Pogliani + Fabio C + FC + + Department of Internal Medicine, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil. + + + + Dai + Tianhong + T + 0000-0001-8960-8896 + + Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. + + + + Sabino + Caetano P + CP + + Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil. + + + Biolambda, Scientific and Commercial Ltd., São Paulo, Brazil. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Microbiol Spectr + 101634614 + 2165-0497 + + IM + + endogenous chromophores + lipid peroxidation + membrane permeabilization + protein carbonylation + reactive oxygen species + +
+ + + + 2023 + 2 + 22 + 13 + 33 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809152 + 10.1128/spectrum.02833-22 + + +
+ + + 36809158 + + 2023 + 02 + 22 + +
+ + 2190-5142 + + 69 + 6 + + 2022 + Nov + + + Experimental psychology + Exp Psychol + + Call for Papers. + + 352-353 + + 10.1027/1618-3169/a000574 + + + Saint-Aubin + Jean + J + + School of Psychology, Université de Moncton, New Brunswick, Canada. + + + + eng + + Journal Article + +
+ + Germany + Exp Psychol + 101138477 + 1618-3169 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 33 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809158 + 10.1027/1618-3169/a000574 + + +
+ + + 36809157 + + 2023 + 02 + 22 + +
+ + 2190-5142 + + 69 + 6 + + 2022 + Nov + + + Experimental psychology + Exp Psychol + + Task Demands Differentially Affect Processing of Intrinsic and Extrinsic Object Features in Working Memory. + + 320-334 + + 10.1027/1618-3169/a000572 + + Some argue that visual working memory operates on integrated object representations. Here, we contend that obligatory feature integration occurs with intrinsic but not extrinsic object features. Working memory for shapes and colors was assessed using a change-detection task with a central test probe, while recording event-related potentials (ERPs). Color was either an intrinsic surface feature of a shape or connected to the shape via a proximal but spatially disjunct extrinsic frame. There were two types of test: The direct test required memory for shape and color; the indirect test required only shape memory. Study-test changes of color were therefore either task-relevant or task-irrelevant. We assessed performance costs and event-related potential (ERP) effects arising from color changes. In the direct test, performance was poorer for extrinsic than intrinsic stimuli; task-relevant color changes elicited enhanced frontal negativity (N2, FN400) for both intrinsic and extrinsic stimuli. In the indirect test, performance costs and ERP effects associated with irrelevant color change were larger for intrinsic than extrinsic stimuli. This suggests intrinsic information is more readily integrated into the working-memory representation and evaluated against the test probe. Findings imply that feature integration is not obligatory under all conditions but influenced by stimulus-driven and task-related focus of attention. + + + + Kirmsse + Alexander + A + 0000-0001-5189-4882 + + Department of Psychology, Brain and Cognition Unit, Saarland University. + + + + Zimmer + Hubert D + HD + 0000-0003-4880-7842 + + Department of Psychology, Brain and Cognition Unit, Saarland University. + + + + Ecker + Ullrich K H + UKH + 0000-0003-4743-313X + + School of Psychological Science, University of Western Australia. + + + + eng + + Journal Article + +
+ + Germany + Exp Psychol + 101138477 + 1618-3169 + + IM + + FN400 + N2 + event-related potentials + feature binding + working memory + +
+ + + + 2023 + 2 + 22 + 13 + 33 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809157 + 10.1027/1618-3169/a000572 + + +
+ + + 36809159 + + 2023 + 02 + 22 + +
+ + 2190-5142 + + 69 + 6 + + 2022 + Nov + + + Experimental psychology + Exp Psychol + + The Effects of Semantic and Syntactic Prediction on Reading Aloud. + + 308-319 + + 10.1027/1618-3169/a000568 + + Semantic and syntactic prediction effects were investigated in a word naming task using semantic or syntactic contexts that varied between three and six words. Participants were asked to read the contexts silently and name a target word, which was indicated by a color change. Semantic contexts were composed of lists of semantically associated words without any syntactic information. Syntactic contexts were composed of semantically neutral sentences, in which the grammatical category but not the lexical identity of the final word was highly predictable. When the presentation time of the context words was long (1,200 ms), both semantically and syntactically related contexts facilitated reading aloud latencies of target words and syntactically related contexts produced larger priming effects than semantically related contexts in two out of three analyses. When the presentation time was short (200 ms), however, syntactic context effects disappeared, while semantic context effects remained significant. Across the three experiments, longer contexts produced faster response latencies, but longer contexts did not produce larger priming effects. The results are discussed in the context of the extant literature on semantic and syntactic priming and more recent evidence, suggesting that syntactic information constrains single word recognition. + + + + Gavard + Elisa + E + 0000-0001-5144-7767 + + Laboratoire de Psychologie Cognitive (UMR 7290), Aix-Marseille Univ, CNRS, Marseille, France. + + + + Ziegler + Johannes C + JC + 0000-0002-2061-5729 + + Laboratoire de Psychologie Cognitive (UMR 7290), Aix-Marseille Univ, CNRS, Marseille, France. + + + + eng + + Journal Article + +
+ + Germany + Exp Psychol + 101138477 + 1618-3169 + + IM + + reading aloud + semantic prediction + syntactic prediction + word recognition + +
+ + + + 2023 + 2 + 22 + 13 + 33 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809159 + 10.1027/1618-3169/a000568 + + +
+ + + 36809168 + + 2023 + 02 + 22 + +
+ + 1557-8585 + + 21 + 1 + + 2023 + Feb + + + Lymphatic research and biology + Lymphat Res Biol + + Research Matters. + + 97 + + 10.1089/lrb.2023.29137.wr + eng + + Journal Article + +
+ + United States + Lymphat Res Biol + 101163587 + 1539-6851 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 34 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809168 + 10.1089/lrb.2023.29137.wr + + +
+ + + 36809162 + + 2023 + 02 + 22 + +
+ + 2190-5142 + + 69 + 6 + + 2022 + Nov + + + Experimental psychology + Exp Psychol + + Correction to Murziakova et al., 2022. + + 351 + + 10.1027/1618-3169/a000570 + eng + + Published Erratum + +
+ + Germany + Exp Psychol + 101138477 + 1618-3169 + + IM + + + Exp Psychol. 2022 Jul;69(4):185-195 + 36305454 + + +
+ + + + 2023 + 2 + 22 + 13 + 33 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809162 + 10.1027/1618-3169/a000570 + + +
+ + + 36809167 + + 2023 + 02 + 22 + +
+ + 1557-8585 + + 21 + 1 + + 2023 + Feb + + + Lymphatic research and biology + Lymphat Res Biol + + Update February 2023. + + 78-96 + + 10.1089/lrb.2023.29136.fb + + + Blei + Francine + F + + Hassenfeld Children's Hospital at NYU Langone, NYU Grossman School of Medicine, New York, New York, USA. + + + + eng + + Journal Article + +
+ + United States + Lymphat Res Biol + 101163587 + 1539-6851 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 34 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809167 + 10.1089/lrb.2023.29136.fb + + +
+ + + 36809161 + + 2023 + 02 + 22 + +
+ + 2190-5142 + + 69 + 6 + + 2022 + Nov + + + Experimental psychology + Exp Psychol + + Alcohol-Induced Retrograde Facilitation? + + 335-350 + + 10.1027/1618-3169/a000569 + + Somewhat counterintuitively, alcohol consumption following learning of new information has been shown to enhance performance on a delayed subsequent memory test. This phenomenon has become known as the retrograde facilitation effect (Parker et al., 1981). Although conceptually replicated repeatedly, serious methodological problems are associated with most previous demonstrations of retrograde facilitation. Moreover, two potential explanations have been proposed, the interference and the consolidation hypothesis. So far, empirical evidence for and against both hypotheses is inconclusive (Wixted, 2004). To scrutinize the existence of the effect, we conducted a pre-registered replication that avoided common methodological pitfalls. In addition, we used Küpper-Tetzel and Erdfelder's (2012) multinomial processing tree (MPT) model to disentangle encoding, maintenance, and retrieval contributions to memory performance. With a total sample size of N = 93, we found no evidence for retrograde facilitation in overall cued or free recall of previously presented word pairs. In line with this, MPT analyses also showed no reliable difference in maintenance probabilities. However, MPT analyses revealed a robust alcohol advantage in retrieval. We conclude that alcohol-induced retrograde facilitation might exist and be driven by an underlying retrieval benefit. Future research is needed to investigate potential moderators and mediators of the effect explicitly. + + + + Quevedo Pütter + J + J + 0000-0002-7340-9937 + + Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany. + + + + Erdfelder + E + E + 0000-0003-1032-3981 + + Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany. + + + + eng + + Journal Article + +
+ + Germany + Exp Psychol + 101138477 + 1618-3169 + + IM + + alcohol + conceptual replication + consolidation hypothesis + interference hypothesis + multinomial processing tree (MPT) modeling + retrograde facilitation + +
+ + + + 2023 + 2 + 22 + 13 + 33 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809161 + 10.1027/1618-3169/a000569 + + +
+ + + 36809164 + + 2023 + 02 + 22 + +
+ + 2165-0497 + + + 2023 + Feb + 21 + + + Microbiology spectrum + Microbiol Spectr + + Trajectory of Humoral Responses to Two Doses of ChAdOx1 nCoV-19 Vaccination in Patients Receiving Maintenance Hemodialysis. + + e0344522 + + 10.1128/spectrum.03445-22 + + The ChAdOx1 nCoV-19 (AZD1222) vaccine is one of the most commonly delivered SARS-CoV-2 vaccines worldwide; however, few clinical studies have investigated its immunogenicity in dialysis patients. We prospectively enrolled 123 patients on maintenance hemodialysis at a medical center in Taiwan. All patients were infection-naive, had received two doses of the AZD1222 vaccine, and were monitored for 7 months. The primary outcomes were anti-SARS-CoV-2 receptor-binding domain (RBD) antibody concentrations before and after each dose and 5 months after the second dose and neutralization capacity against ancestral SARS-CoV-2, delta, and omicron variants. The anti-SARS-CoV-2 RBD antibody titers significantly increased with time following vaccination, with a peak at 1 month after the second dose (median titer, 498.8 U/mL; interquartile range, 162.5 to 1,050 U/mL), and a 4.7-fold decrease at 5 months. At 1 month after the second dose, 84.6, 83.7, and 1.6% of the participants had neutralizing antibodies against the ancestral virus, delta variant, and omicron variant, respectively, measured by a commercial surrogate neutralization assay. The geometric mean 50% pseudovirus neutralization titers for the ancestral virus, delta variant, and omicron variant were 639.1, 264.2, and 24.7, respectively. The anti-RBD antibody titers correlated well with neutralization capacity against the ancestral virus and delta variant. Transferrin saturation and C-reactive protein were associated with neutralization against the ancestral virus and delta variant. Although two doses of the AZD1222 vaccine initially elicited high anti-RBD antibody titers and neutralization against the ancestral virus and delta variant in hemodialysis patients, neutralizing antibodies against omicron variant were rarely detected, and the anti-RBD and neutralization antibodies waned over time. Additional/booster vaccinations are warranted in this population. IMPORTANCE Patients with kidney failure have worse immune response following vaccination compared to general population, but few clinical studies have investigated immunogenicity of ChAdOx1 nCoV-19 (AZD1222) vaccination in hemodialysis patients. Here, we showed two doses of AZD1222 vaccines lead to high seroconversion rate of anti-SARS-CoV-2 receptor-binding domain (RBD) antibodies, and more than 80% patients acquired neutralizing antibodies against ancestral virus and delta variant. However, seldom did they obtain neutralizing antibodies against the omicron variant. The geometric mean 50% pseudovirus neutralization titer against the ancestral virus was 25.9-fold higher than that against the omicron variant. Also, there was a substantial decay in anti-RBD titers with time. Our findings provided evidence supporting that more protective measures, including additional/booster vaccinations, is warranted in these patients during the current COVID-19 pandemic. + + + + Ling + Tsai-Chieh + TC + + Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. + + + + Chen + Po-Lin + PL + + Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. + + + Infection Control Center, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. + + + Department of Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan. + + + + Li + Nan-Yao + NY + + Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. + + + + Ko + Wen-Chien + WC + + Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. + + + Department of Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan. + + + + Sun + Chien-Yao + CY + + Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. + + + Department of Geriatrics and Gerontology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. + + + + Chao + Jo-Yen + JY + + Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. + + + + Shieh + Chi-Chang + CC + + Department of Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan. + + + Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. + + + Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan. + + + + Shen + Ching-Fen + CF + + Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. + + + Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan. + + + + Wu + Jia-Ling + JL + + Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. + + + Department of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan. + + + + Huang + Teng-Ching + TC + + Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. + + + + Chao + Chiao-Hsuan + CH + + Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan. + + + + Wang + Jen-Ren + JR + + Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan. + + + National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Tainan, Taiwan. + + + + Chang + Yu-Tzu + YT + 0000-0003-1449-9431 + + Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Microbiol Spectr + 101634614 + 2165-0497 + + IM + + COVID-19 + ChAdOx1 nCoV-19 vaccine + anti-SARS-CoV-2 RBD antibody + hemodialysis + neutralizing antibody + variants of concern + +
+ + + + 2023 + 2 + 22 + 13 + 33 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809164 + 10.1128/spectrum.03445-22 + + +
+ + + 36809172 + + 2023 + 02 + 22 + +
+ + 1471-1753 + + + 2023 + Feb + 21 + + + The Journal of dermatological treatment + J Dermatolog Treat + + Upadacitinib for the Treatment of Concomitant Psoriasis and Atopic Dermatitis: a Case Series. + + 1-5 + + 10.1080/09546634.2023.2183729 + + The overlap of psoriasis and atopic dermatitis (AD) is rare and treating moderate-to-severe cases can be challenging. Conventional immune-suppressive drugs cannot be used long-term, and no biological drugs are currently approved for treating both conditions.We report the cases of four patients with overlapping features of both psoriasis and AD. After being treated with several systemic drugs, including gold-standard treatments for both psoriasis and AD, they received upadacitinib 15 or 30 mg, achieving complete remission.Upadacitinib is an inhibitor of Janus Kinase 1, currently approved for treating moderate-to-severe AD. To date, very limited data are available regarding the efficacy of upadacitinib in psoriasis. In a phase-3 trial on the efficacy of upadacitinib 15 mg in patients affected by psoriatic arthritis, 52.3% of patients achieved a 75% improvement in Psoriasis Area and Severity Index (PASI75) after one year. Currently, no clinical trials are evaluating the efficacy of upadacitinib in plaque psoriasis. + + + + Gargiulo + Luigi + L + + Department of Biomedical Sciences, Humanitas University, Pieve Emanuele (MI), Italy. + + + Dermatology Unit, IRCCS Humanitas Research Hospital, Rozzano (MI), Italy. + + + + Ibba + Luciano + L + + Department of Biomedical Sciences, Humanitas University, Pieve Emanuele (MI), Italy. + + + Dermatology Unit, IRCCS Humanitas Research Hospital, Rozzano (MI), Italy. + + + + Pavia + Giulia + G + + Department of Biomedical Sciences, Humanitas University, Pieve Emanuele (MI), Italy. + + + Dermatology Unit, IRCCS Humanitas Research Hospital, Rozzano (MI), Italy. + + + + Avagliano + Jessica + J + + Dermatology Unit, IRCCS Humanitas Research Hospital, Rozzano (MI), Italy. + + + + Cortese + Andrea + A + + Department of Biomedical Sciences, Humanitas University, Pieve Emanuele (MI), Italy. + + + Dermatology Unit, IRCCS Humanitas Research Hospital, Rozzano (MI), Italy. + + + + Costanzo + Antonio + A + + Department of Biomedical Sciences, Humanitas University, Pieve Emanuele (MI), Italy. + + + Dermatology Unit, IRCCS Humanitas Research Hospital, Rozzano (MI), Italy. + + + + Narcisi + Alessandra + A + + Dermatology Unit, IRCCS Humanitas Research Hospital, Rozzano (MI), Italy. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + J Dermatolog Treat + 8918133 + 0954-6634 + + IM + + atopic dermatitis + psoriasis + upadacitinib + +
+ + + + 2023 + 2 + 22 + 13 + 34 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809172 + 10.1080/09546634.2023.2183729 + + +
+ + + 36809173 + + 2023 + 02 + 22 + +
+ + 1945-0257 + + + 2023 + Feb + 20 + + + Genetic testing and molecular biomarkers + Genet Test Mol Biomarkers + + Prognostic Value of Transglutaminase 2 in Patients with Solid Tumors: A Meta-analysis. + 10.1089/gtmb.2022.0088 + + Background: Transglutaminase 2 (TG2), a member of the transglutaminase family, also known as tissue transglutaminase, plays a fundamental role in cancer growth and progression. In this study, we aimed to comprehensively review the evidence of TG2 as a prognostic biomarker in solid tumors. Methods: PubMed, Embase, and Cochrane databases were searched for human studies with clearly described cancer types if they presented the relationship between TG2 expression and prognostic indicators from inception to February 2022. Two authors independently screened the eligible studies and extracted the relevant data. The association between TG2 and overall survival (OS), disease-free survival (DFS), and relapse-free survival (RFS) was described as hazard ratio (HR) and their corresponding 95% confidence intervals (CIs). Statistical heterogeneity was assessed using Cochrane Q-test and Higgins I-squared statistic. A sensitivity analysis was conducted by sequentially omitting the impact of each study. Publication bias was assessed by Egger's funnel plot. Results: A total of 2864 patients with various cancers from 11 individual studies were enrolled. Results showed that elevated TG2 protein expression and mRNA expression could predict a shorter OS, with a combined HR of 1.93 (95% CI: 1.41-2.63) or HR of 1.95 (95% CI: 1.27-2.99), respectively. Moreover, data suggested that elevated TG2 protein expression was correlated with a shorter DFS (HR = 1.76, 95% CI: 1.36-2.29); whereas elevated TG2 mRNA expression was associated with a shorter DFS (HR = 1.71, 95% CI: 1.30-2.24). Conclusions: Our meta-analysis indicated that TG2 might serve as a promising biomarker of cancer prognosis. + + + + Gao + Jie + J + + Department of Transfusion Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China. + + + + Wang + Shengjiang + S + + Department of Transfusion Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China. + + + + Wan + Haiyan + H + + Department of Transfusion Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China. + + + + Lan + Jinfeng + J + + Department of Transfusion Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China. + + + + Yan + Yong + Y + + Department of Transfusion Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China. + + + + Yin + Dongmei + D + + Department of Transfusion Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China. + + + + Zhou + Wenjing + W + + Department of Transfusion Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China. + + + + Hun + Shouyong + S + + Department of Transfusion Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China. + + + + He + Qi + Q + 0000-0002-1827-2456 + + Department of Transfusion Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China. + + + + eng + + Journal Article + + + 2023 + 02 + 20 + +
+ + United States + Genet Test Mol Biomarkers + 101494210 + 1945-0257 + + IM + + cancer biomarker + meta-analysis + solid tumor + transglutaminase 2 (TG2) + +
+ + + + 2023 + 2 + 22 + 13 + 34 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809173 + 10.1089/gtmb.2022.0088 + + +
+ + + 36809187 + + 2023 + 02 + 22 + +
+ + 1559-8519 + + + 2023 + Feb + 21 + + + Journal of sex research + J Sex Res + + Small Effects, Questionable Outcomes: Bremelanotide for Hypoactive Sexual Desire Disorder. + + 1-22 + + 10.1080/00224499.2023.2175192 + + Efficacy outcomes are only informative to the extent that they are validated. We examined the measurement properties of efficacy measures from the phase III ("RECONNECT") bremelanotide trials for hypoactive sexual desire disorder (HSDD) in women. Continuous efficacy outcomes, including a) the Female Sexual Function Index (FSFI) and its Desire domain (FSFI-D) and b) the Female Sexual Distress Scale-Desire/Arousal/Orgasm (FSDS-DAO) and its item assessing distress due to low desire (FSDS-DAO #13) have questionable, at best, validity evidence for women with HSDD. We found no validity evidence for previously published categorical treatment response outcomes from the RECONNECT trials. All efficacy results should be reported, but results on 8 of the 11 clinicaltrials.gov-specified efficacy outcomes were heretofore unpublished (including FSDS-DAO total score, FSFI total score, FSFI arousal domain, and items from the Female Sexual Encounter Profile-Revised). We analyzed these outcomes, upon which effect sizes ranged from nil to small. Several other continuous and categorical outcomes generated modest apparent benefits, though nearly all of these outcomes were likely derived post-hoc. Across RECONNECT trial data from two prior publications and the current study, bremelanotide's benefits are statistically modest and limited to outcomes for which scant evidence of validity among women with HSDD exists. + + + + Spielmans + Glen I + GI + + Department of Psychology, Metropolitan State University, Saint Paul, Minnesota, USA. + + + + Ellefson + Elaine M + EM + + Department of Psychology, Metropolitan State University, Saint Paul, Minnesota, USA. + + + + eng + + Journal Article + Review + + + 2023 + 02 + 21 + +
+ + United States + J Sex Res + 0062647 + 0022-4499 + + IM + + Bremelanotide + Female Sexual Distress Scale + Female Sexual Function Index + hypoactive sexual desire disorder + review + +
+ + + + 2023 + 2 + 22 + 13 + 35 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809187 + 10.1080/00224499.2023.2175192 + + +
+ + + 36809160 + + 2023 + 02 + 22 + +
+ + 2190-5142 + + 69 + 6 + + 2022 + Nov + + + Experimental psychology + Exp Psychol + + The Influence of Posture on Attention. + + 295-307 + + 10.1027/1618-3169/a000567 + + Smith et al. (2019) found standing resulted in better performance than sitting in three different cognitive control paradigms: a Stroop task, a task-switching, and a visual search paradigm. Here, we conducted close replications of the authors' three experiments using larger sample sizes than the original work. Our sample sizes had essentially perfect power to detect the key postural effects reported by Smith et al. The results from our experiments revealed that, in contrast to Smith et al., the postural interactions were quite limited in magnitude in addition to being only a fraction of the size of the original effects. Moreover, our results from Experiment 1 are consistent with two recent replications (Caron et al., 2020; Straub et al., 2022), which reported no meaningful influences of posture on the Stroop effect. In all, the current research provides further converging evidence that postural influences on cognition do not appear to be as robust, as was initially reported in prior work. + + + + Caron + Emilie E + EE + 0000-0003-4016-3560 + + Department of Psychology, University of Waterloo, Ontario, Canada. + + + + Marusich + Laura R + LR + 0000-0002-3524-6110 + + DEVCOM U.S. Army Research Laboratory, Austin, TX, USA. + + + + Bakdash + Jonathan Z + JZ + 0000-0002-1409-4779 + + DEVCOM U.S. Army Research Laboratory, Austin, TX, USA. + + + + Ballotti + Reynolds J + RJ + 0000-0001-7331-7891 + + Department of Psychology and Special Education, Texas A&M University-Commerce, Commerce, TX, USA. + + + + Tague + Andrew M + AM + + Department of Psychology and Special Education, Texas A&M University-Commerce, Commerce, TX, USA. + + + + Carriere + Jonathan S A + JSA + + Department of Psychology, Bishop's University, Sherbrook, Quebec, Canada. + + + + Smilek + Daniel + D + + Department of Psychology, University of Waterloo, Ontario, Canada. + + + + Harter + Derek + D + + Department of Computer Science and Information Systems, Texas A&M University-Commerce, Commerce, TX, USA. + + + + Lu + Shulan + S + + Department of Psychology and Special Education, Texas A&M University-Commerce, Commerce, TX, USA. + + + + Reynolds + Michael G + MG + + Department of Psychology, Trent University, Peterborough, Ontario, Canada. + + + + eng + + Journal Article + +
+ + Germany + Exp Psychol + 101138477 + 1618-3169 + + IM + + attention + cognitive control + embodiment + posture + standing + +
+ + + + 2023 + 2 + 22 + 13 + 33 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809160 + 10.1027/1618-3169/a000567 + + +
+ + + 36809163 + + 2023 + 02 + 22 + +
+ + 1945-0257 + + + 2023 + Feb + 20 + + + Genetic testing and molecular biomarkers + Genet Test Mol Biomarkers + + Socioeconomic Barriers Surrounding Genetic Counseling. + 10.1089/gtmb.2022.29066.persp + + + Korte + Kealy T + KT + + Genetic Alliance, Damascus, Maryland, USA. + + + University of Mississippi, Oxford, Mississippi, USA. + + + + Terry + Sharon F + SF + + Genetic Alliance, Damascus, Maryland, USA. + + + + eng + + Journal Article + + + 2023 + 02 + 20 + +
+ + United States + Genet Test Mol Biomarkers + 101494210 + 1945-0257 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 33 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809163 + 10.1089/gtmb.2022.29066.persp + + +
+ + + 36809166 + + 2023 + 02 + 22 + +
+ + 1879-0852 + + 177 + + 2022 + Dec + + + European journal of cancer (Oxford, England : 1990) + Eur J Cancer + + Immune checkpoint inhibitor-associated myocarditis and coronary artery disease: There may be more than meets the eye! + + 194-196 + + S0959-8049(22)00768-7 + 10.1016/j.ejca.2022.09.028 + + + Maria + Alexandre T J + ATJ + + Internal Medicine & Immuno-Oncology (MedI(2)O), Institute for Regenerative Medicine and Biotherapy (IRMB), Saint Eloi Hospital, Montpellier University Hospital, Montpellier, France. + + + + Delmas + Clement + C + + Cardiology Department INI-CRT PhyMedExp INSERM CNRS CHU de Montpellier Université de Montpellier France, France. + + + + Coustal + Cyrille + C + + Department of Internal Medicine, Multi-Organic Diseases, Local Referral Center for Rare Auto-immune Diseases, Montpellier University Hospital, Montpellier, France. + + + + Palassin + Pascale + P + + Regional Pharmacovigilance Centre, Department of Medical Pharmacology and Toxicology, Montpellier University Hospital, Montpellier, France. + + + + Roubille + François + F + + Cardiology Department INI-CRT PhyMedExp INSERM CNRS CHU de Montpellier Université de Montpellier France, France. Electronic address: francois.roubille@gmail.com. + + + + eng + + Editorial + + + 2022 + 10 + 04 + +
+ + England + Eur J Cancer + 9005373 + 0959-8049 + + IM + + Coronary angiogram + Heart failure + Immune checkpoint blocker + Immune-related adverse events + Myocardial biopsy + Myocarditis + + Conflict of interest statement The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. +
+ + + + 2022 + 09 + 05 + + + 2022 + 09 + 24 + + + 2023 + 2 + 22 + 13 + 34 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809166 + S0959-8049(22)00768-7 + 10.1016/j.ejca.2022.09.028 + + +
+ + + 36809169 + + 2023 + 02 + 22 + +
+ + 1557-8585 + + 21 + 1 + + 2023 + Feb + + + Lymphatic research and biology + Lymphat Res Biol + + Acknowledgment of Reviewers 2022. + + 98 + + 10.1089/lrb.2022.29135.ack + eng + + Journal Article + +
+ + United States + Lymphat Res Biol + 101163587 + 1539-6851 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 34 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809169 + 10.1089/lrb.2022.29135.ack + + +
+ + + 36809165 + + 2023 + 02 + 22 + +
+ + 1559-7016 + + + 2023 + Feb + 21 + + + Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism + J Cereb Blood Flow Metab + + A SPECT-based method for dynamic imaging of the glymphatic system in rats. + + 271678X231156982 + + 10.1177/0271678X231156982 + + The glymphatic system is a brain-wide waste drainage system that promotes cerebrospinal fluid circulation through the brain to remove waste metabolites. Currently, the most common methods for assessing glymphatic function are ex vivo fluorescence microscopy of brain slices, macroscopic cortical imaging, and MRI. While all these methods have been crucial for expanding our understanding of the glymphatic system, new techniques are required to overcome their specific drawbacks. Here, we evaluate SPECT/CT imaging as a tool to assess glymphatic function in different anesthesia-induced brain states using two radiolabeled tracers, [111In]-DTPA and [99mTc]-NanoScan. Using SPECT, we confirmed the existence of brain state-dependent differences in glymphatic flow and we show brain state-dependent differences of CSF flow kinetics and CSF egress to the lymph nodes. We compare SPECT and MRI for imaging glymphatic flow and find that the two imaging modalities show the same overall pattern of CSF flow, but that SPECT was specific across a greater range of tracer concentrations than MRI. Overall, we find that SPECT imaging is a promising tool for imaging the glymphatic system, and that qualities such as high sensitivity and the variety of available tracers make SPECT imaging a good alternative for glymphatic research. + + + + Sigurdsson + Björn + B + 0000-0002-7484-7779 + + Center for Translational Neuromedicine, University of Copenhagen, Denmark. + + + + Hauglund + Natalie L + NL + 0000-0002-2198-6329 + + Center for Translational Neuromedicine, University of Copenhagen, Denmark. + + + + Lilius + Tuomas O + TO + + Center for Translational Neuromedicine, University of Copenhagen, Denmark. + + + INDIVIDRUG Research Program, University of Helsinki, Finland. + + + Department of Pharmacology, University of Helsinki, Finland. + + + Department of Emergency Medicine and Services, Helsinki University Hospital and University of Helsinki, Finland. + + + + Mogensen + Frida L-H + FL + 0000-0002-3497-2321 + + Center for Translational Neuromedicine, University of Copenhagen, Denmark. + + + Neuro-Immunology Group, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg. + + + Doctoral School of Science and Technology, University of Luxembourg, Esch-sur-Alzette, Luxembourg. + + + + Mortensen + Kristian N + KN + + Center for Translational Neuromedicine, University of Copenhagen, Denmark. + + + + Beschorner + Natalie + N + + Center for Translational Neuromedicine, University of Copenhagen, Denmark. + + + + Klinger + Laura + L + + Center for Translational Neuromedicine, University of Copenhagen, Denmark. + + + + Bærentzen + Simone L + SL + + Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. + + + Department of Nuclear Medicine and PET Center, Aarhus University Hospital, Aarhus, Denmark. + + + + Rosenholm + Marko P + MP + 0000-0002-5437-8282 + + Center for Translational Neuromedicine, University of Copenhagen, Denmark. + + + + Shalgunov + Vladimir + V + + Department of Drug Design and Pharmacology, University of Copenhagen, Denmark. + + + + Herth + Matthias + M + + Department of Drug Design and Pharmacology, University of Copenhagen, Denmark. + + + Department of Clinical Physiology, Copenhagen University Hospital, Denmark. + + + + Mori + Yuki + Y + + Center for Translational Neuromedicine, University of Copenhagen, Denmark. + + + + Nedergaard + Maiken + M + + Center for Translational Neuromedicine, University of Copenhagen, Denmark. + + + Center for Translational Neuromedicine, University of Rochester Medical Center, USA. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + J Cereb Blood Flow Metab + 8112566 + 0271-678X + + IM + + Waste clearance + [111In]-DTPA + cerebrospinal fluid dynamics + lymph nodes + rat brain + +
+ + + + 2023 + 2 + 22 + 13 + 33 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809165 + 10.1177/0271678X231156982 + + +
+ + + 36809171 + + 2023 + 02 + 22 + +
+ + 1929-0748 + + 12 + + 2023 + Feb + 21 + + + JMIR research protocols + JMIR Res Protoc + + Using a Safety Planning Mobile App to Address Suicidality in Young People Attending Community Mental Health Services in Ireland: Protocol for a Pilot Randomized Controlled Trial. + + e44205 + + 10.2196/44205 + + Over 700,000 people die by suicide annually, making it the fourth leading cause of death among those aged 15-29 years globally. Safety planning is recommended best practice when individuals at risk of suicide present to health services. A safety plan, developed in collaboration with a health care practitioner, details the steps to be taken in an emotional crisis. SafePlan, a safety planning mobile app, was designed to support young people experiencing suicidal thoughts and behaviors and to record their plan in a way that is accessible immediately and in situ. + The aim of this study is to assess the feasibility and acceptability of the SafePlan mobile app for patients experiencing suicidal thoughts and behaviors and their clinicians within Irish community mental health services, examine the feasibility of study procedures for both patients and clinicians, and determine if the SafePlan condition yields superior outcomes when compared with the control condition. + A total of 80 participants aged 16-35 years accessing Irish mental health services will be randomized (1:1) to receive the SafePlan app plus treatment as usual or treatment as usual plus a paper-based safety plan. The feasibility and acceptability of the SafePlan app and study procedures will be evaluated using both qualitative and quantitative methodologies. The primary outcomes are feasibility outcomes and include the acceptability of the app to participants and clinicians, the feasibility of delivery in this setting, recruitment, retention, and app use. The feasibility and acceptability of the following measures in a full randomized controlled trial will also be assessed: the Beck Scale for Suicide Ideation, Columbia Suicide Severity Rating Scale, Coping Self-Efficacy Scale, Interpersonal Needs Questionnaire, and Client Service Receipt Inventory. A repeated measures design with outcome data collected at baseline, post intervention (8 weeks), and at 6-month follow-up will be used to compare changes in suicidal ideation for the intervention condition relative to the waitlist control condition. A cost-outcome description will also be undertaken. Thematic analyses will be used to analyze the qualitative data gathered through semistructured interviews with patients and clinicians. + As of January 2023, funding and ethics approval have been acquired, and clinician champions across mental health service sites have been established. Data collection is expected to commence by April 2023. The submission of completed manuscript is expected by April 2025. + The framework for Decision-making after Pilot and feasibility Trials will inform the decision to progress to a full trial. The results will inform patients, researchers, clinicians, and health services of the feasibility and acceptability of the SafePlan app in community mental health services. The findings will have implications for further research and policy regarding the broader integration of safety planning apps. + OSF Registries osf.io/3y54m; https://osf.io/3y54m. + PRR1-10.2196/44205. + ©Ruth Melia, Kady Francis, Jim Duggan, John Bogue, Mary O'Sullivan, Karen Young, Derek Chambers, Shane J McInerney, Edmond O'Dea, Rebecca Bernert. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 21.02.2023. + + + + Melia + Ruth + R + https://orcid.org/0000-0002-1152-5510 + + Department of Psychology, University of Limerick, Limerick, Ireland. + + + School of Psychology, University of Galway, Galway, Ireland. + + + Health Service Executive Community Healthcare Mid West, Limerick, Ireland. + + + + Francis + Kady + K + https://orcid.org/0000-0001-8161-4546 + + School of Psychology, University of Galway, Galway, Ireland. + + + Health Service Executive Community Healthcare West, Galway, Ireland. + + + + Duggan + Jim + J + https://orcid.org/0000-0002-7507-8617 + + Insight Centre for Data Analytics, University of Galway, Galway, Ireland. + + + + Bogue + John + J + https://orcid.org/0000-0002-7070-1561 + + School of Psychology, University of Galway, Galway, Ireland. + + + + O'Sullivan + Mary + M + https://orcid.org/0000-0003-0832-6921 + + Health Service Executive Community Healthcare West, Galway, Ireland. + + + + Young + Karen + K + https://orcid.org/0000-0002-9452-2293 + + College of Engineering and Informatics, University of Galway, Galway, Ireland. + + + + Chambers + Derek + D + https://orcid.org/0000-0002-7670-3058 + + Health Service Executive, Dublin, Ireland. + + + + McInerney + Shane J + SJ + https://orcid.org/0000-0003-1062-6464 + + Health Service Executive Community Healthcare West, Galway, Ireland. + + + Department of Psychiatry, University of Galway, Galway, Ireland. + + + + O'Dea + Edmond + E + https://orcid.org/0000-0003-2402-4093 + + Department of Psychology, University of Limerick, Limerick, Ireland. + + + + Bernert + Rebecca + R + https://orcid.org/0000-0002-1677-6749 + + Department of Psychiatry and Behavioral Science, Stanford University, Palo Alto, CA, United States. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Canada + JMIR Res Protoc + 101599504 + 1929-0748 + + + SafePlan + mHealth + mobile health + mobile phone + safety planning + suicide prevention + +
+ + + + 2022 + 11 + 10 + + + 2023 + 01 + 10 + + + 2023 + 01 + 09 + + + 2023 + 2 + 22 + 13 + 34 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809171 + v12i1e44205 + 10.2196/44205 + + +
+ + + 36809170 + + 2023 + 02 + 22 + +
+ + 1557-8585 + + 21 + 1 + + 2023 + Feb + + + Lymphatic research and biology + Lymphat Res Biol + + Lymphedema: A Symphony of Fat and Scar. + + 1 + + 10.1089/lrb.2023.29138.editorial + + + Rockson + Stanley G + SG + Editor-in-Chief + + Stanford University School of Medicine, Stanford, California, USA. + + + + eng + + Editorial + +
+ + United States + Lymphat Res Biol + 101163587 + 1539-6851 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 34 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809170 + 10.1089/lrb.2023.29138.editorial + + +
+ + + 36809188 + + 2023 + 02 + 22 + +
+ + 1524-4725 + + + 2023 + Feb + 20 + + + Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] + Dermatol Surg + + Earlobe Rejuvenation: A Review of Current Treatment Modalities. + 10.1097/DSS.0000000000003709 + + As one of the defining features of the face, the ear influences perceptions of beauty. Despite its significance, comparatively little is known about rejuvenation options for the ear. + To provide a comprehensive review of minimally invasive options for earlobe rejuvenation. + & Materials: Cochrane, Embase, and PubMed were used to identify articles exploring minimally invasive treatments for ear rejuvenation. + Topical medications, peels, fillers, lasers, photodynamic therapy, and dermabrasion are safe and efficacious for managing a variety of concerns related to earlobe aesthetics. + Numerous minimally invasive treatment modalities are available for earlobe rejuvenation; further investigation is needed to design a grading system and treatment algorithm. + Copyright © 2023 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved. + + + + Azzawi + Soraya + S + + Both authors are affiliated with the Phillip Frost Department of Dermatology, University of Miami. + + + + Aigen + Alyx Rosen + AR + + + eng + + Journal Article + + + 2023 + 02 + 20 + +
+ + United States + Dermatol Surg + 9504371 + 1076-0512 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 35 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809188 + 10.1097/DSS.0000000000003709 + 00042728-990000000-00296 + + + + Qian W, Zhang YK, Cao Q, Hou Y, et al. Clinical application of earlobe augmentation with hyaluronic acid filler in the Chinese population. Aesthet Plast Surg 2017;41:185–90. + + + Horlock N, Vögelin E, Bradbury ET, Grobbelaar AO, Gault DT. Psychosocial outcome of patients after ear reconstruction: a retrospective study of 62 patients. Ann Plast Surg 2005;54:517–24. doi: + + + Steffen A, Klaiber S, Katzbach R, Nitsch S, et al. The psychosocial consequences of reconstruction of severe ear defects or third-degree microtia with rib cartilage. Aesthet Surg J 2008;28:404–11 + + + Shonka DC Jr, Park SS. Ear defects. Facial Plast Surg Clin North Am 2009;17:429–43. + + + Farkas LG, Posnick JC, Hreczko TM. Anthropometric growth study of the ear. Cleft Palate-Craniofacial J 1992;29:324–9. PMID: 1643061. doi: + + + Adamson JE, Hortox CE, Crawford HH. The growth pattern of the external ear. Plast Reconstr Surg 1965;36:466–70. + + + Tolleth H. Artistic anatomy, dimensions, and proportions of the external ear. Clin Plast Surg 1978;5:337–45. PMID: 699488. + + + Posnick JC, al-Qattan MM, Whitaker LA. Assessment of the preferred vertical position of the ear. Plast Reconstr Surg 1993;91:1198–203. discussion 1204-7. PMID: 8497519. + + + Farkas LG. Anthropometry of the normal and defective ear. Clin Plast Surg 1990;17:213–21. PMID: 2189638. + + + Skiles MS, Randall P. The anesthetics of ear placement: an experimental study. Plast Reconstr Surg 1983;72:133–40. doi: .6878487. + + + Fu F, Luximon Y. A systematic review on ear anthropometry and its industrial design applications. Hum Factors Ergon Manufacturing Serv Industries 2020;30:176–94. + + + Alexander KS, Stott DJ, Sivakumar B, Kang N. A morphometric study of the human ear. J Plast Reconstr Aesthet Surg 2011;64:41–7. Epub 2010 May 5. PMID: 20447883. doi: + + + McKinney P, Giese S, Placik O. Management of the ear in rhytidectomy. Plast Reconstr Surg 1993;92:858–66. PMID: 8415967. + + + Azaria R, Adler N, Silfen R, Regev D, Hauben DJ. (Vol 111). DE.; 2003; pp. 2398–402. ; discussion 2403-4PMID: 12794488. doi: .Morphometry of the adult human earlobe: a study of 547 subjects and clinical applicationPlast Reconstr Surg7. + + + Mowlavi A, Meldrum DG, Wilhelmi BJ, Ghavami A, Zook EG. The aesthetic earlobe: classification of lobule ptosis on the basis of a survey of North American Caucasians. Plast Reconstr Surg 2003;112:266–72. discussion 273-4PMID: 12832904. doi: + + + Mowlavi A, Meldrum DG, Wilhelmi BJ, Zook EG. Incidence of earlobe ptosis and pseudoptosis in patients seeking facial rejuvenation surgery and effects of aging. Plast Reconstr Surg 2004;113:712–7. PMID: 14758240. doi: + + + Antoniou C, Kosmadaki MG, Stratigos AJ, Katsambas AD. (Vol 11). PMID; 201020141230; pp. 95–102. doi: .Photoaging: prevention and topical treatmentsAm J Clin Dermatol2. + + + Geng A, Weinstock MA, Hall R, Eilers D, et al. VATTC Trial Group. Tolerability of high-dose topical tretinoin: the Veterans Affairs topical tretinoin chemoprevention trial. Br J Dermatol 2009;161:918–24. Epub 2009 Jun 11. PMID: 19681859. doi: + + + Korgavkar K, Lee KC, Weinstock MA. (Vol 153). PMCID; 2017; pp. 1142PMC5710428–1146. doi: .Veterans Affairs keratinocyte carcinoma chemoprevention (VAKCC) trial group. Effect of topical fluorouracil cream on photodamage: secondary analysis of a randomized clinical trialJAMA Dermatol. + + + Stewart CE 4th, Kim JY. Application of mitomycin-C for head and neck keloids. Otolaryngol Head Neck Surg 2006;135:946–50. doi: + + + Jacob SE, Berman B, Nassiri M, Vincek V. Topical application of imiquimod 5% cream to keloids alters expression genes associated with apoptosis. Br J Dermatol 2003;149:62–5. PMID: 14616355. doi: + + + Martin-García RF, Busquets AC. Postsurgical use of imiquimod 5% cream in the prevention of earlobe keloid recurrences: results of an open-label, pilot study. Dermatol Surg 2005;31:1394–8. doi: + + + Har-Shai Y, Sabo E, Rohde E, Hyams M, et al. Intralesional cryosurgery enhances the involution of recalcitrant auricular keloids: a new clinical approach supported by experimental studies. Wound Repair Regeneration: Official Publication Wound Healing Soc [and] Eur Tissue Repair SocietyErratum Wound Repair Regen 2006;1415:18163–27. PMID: 16476068. doi: + + + Fikrle T, Pizinger K. Cryosurgery in the treatment of earlobe keloids: report of seven cases. Dermatol Surg 2005;31:1728–31. doi: + + + Froelich K, Staudenmaier R, Kleinsasser N, Hagen R. Therapy of auricular keloids: review of different treatment modalities and proposal for a therapeutic algorithm. Eur Arch Otorhinolaryngol 2007;264:1497–508. Epub 2007 Jul 13. PMID: 17628822. doi: + + + Lawrence WT. Treatment of earlobe keloids with surgery plus adjuvant intralesional verapamil and pressure earrings. Ann Plast Surg 1996;37:167–9. + + + Brauer JA, Patel U, Hale EK. Laser skin resurfacing, chemical peels, and other cutaneous treatments of the brow and upper lid. Clin Plast Surg 2013;40:91–9. PMID: 23186758. doi: + + + Camacho FM. Medium-depth and deep chemical peels. J Cosmet Dermatol 2005;4:117–28. doi: + + + Elle JJ, Wolff S. Skin peeling and scarification. JAMA 1991;116:934–41. + + + Fulton JE, Porumb S. Chemical peels: their place within the range of resurfacing techniques. Am J Clin Dermatol 2004;5:179–87. PMID: 15186197. doi: + + + Stuzin JM, Baker TJ, Gordon HL. Treatment of photoaging. Facial chemical peeling (phenol and trichloroacetic acid) and dermabrasion. Clin Plast Surg 1993;20:9–25. PMID: 8420712. + + + Lee JC, Daniels MA, Roth MZ. Mesotherapy, microneedling, and chemical peels. Clin Plast Surg 2016;43:583–95. Epub 2016 May 11. PMID: 27363773. doi: + + + de mendonça MCC, de oliveira ARMR, Araújo JMF, Tavares lopes silva MDG, Gamonal A. Nonsurgical technique for incomplete earlobe cleft repair. Dermatol Surg 2009;35:446–50. PMID: 19250307. doi: + + + Arora G, Arora S. Rejuvenating earlobe esthetics with dermal fillers. J Cosmet Dermatol 2021;21:2788–92. Epub ahead of print. PMID: 34687587. doi: + + + Di Gregorio C, D'Arpa S. Nonsurgical treatment of earlobe aging in Mowlavi stages I and II earlobe ptosis with Hyaluronic acid fillers. J Cosmet Dermatol 2019;18:508–10. Epub 2018 Jul 11. PMID: 29992721. doi: + + + Fallacara A, Manfredini S, Durini E, Vertuani S. Hyaluronic acid fillers in soft tissue RegenerationEpub 2017 feb 22. Erratum in. Facial Plast Surgfacial Plast Surg 2017;3333:087244–096. PMID: 28226376. doi: + + + Zeng Y, Zheng YQ. Successful treatment of congenital melanocytic nevus on tragus with CO2 laser. J Dermatol Treat 2014;25:287–9. PMID: 23534922. doi: + + + Rajpal N, Dilorenzo A, Parsa K, Hoa M, Ronkainen S. Bilateral epidermal nevi in the external auditory canals treated with CO2 laser. Pediatr Dermatol 2020;37:388–9. Epub 2020 Jan 10. PMID: 31922614. doi: + + + Sohn S, Kim S, Kang WH. Recurrent pigmented macules after q-switched alexandrite laser treatment of congenital melanocytic nevus. Dermatol Surg 2004;30:898–907. ; discussion 907. doi: + + + Herbich GJ. Laser surgery for traumatic incomplete earlobe clefts. Dermatol Surg 2002;28:761–2. + + + Ravanfar P, Alster TS. Laser earlobe revision. Dermatol Surg 2013;39:1056–61. Epub 2013 Apr 29. PMID: 23627931. doi: + + + Park JW, Shin SH, Koh YG, Seok J, et al. Keloid of earlobe treated with a combination of pneumatic injector device and CO2 fractional laser. Dermatol Ther 2022;35:e15474. Epub 2022 Apr 5. PMID: 35352443. doi: 10.1111/dth.15474 + + 10.1111/dth.15474 + + + + Piccolo D, Crisman G, Bovani B, Gennai A, et al. Combined laser treatment for ear keloids: case series. J Cosmet Dermatol 2022;21:296–306. Epub 2021 Nov 10. PMID: 34757676. doi: + + + Karrer S, Kohl E, Feise K, Hiepe-Wegener D, et al. Photodynamic therapy for skin rejuvenation: review and summary of the literature--results of a consensus conference of an expert group for aesthetic photodynamic therapy. JDDG: J der Deutschen Dermatologischen Gesellschaft 2013;11:137–48. PMID: 23190505. doi: + + + Rodriguez-Prieto MA. Treatment of earlobe keloids with intralesional photodynamic therapy. J Am Acad Dermatol 2016:AB291. + + + Weiss RA, Weiss MA, Beasley KL. Rejuvenation of photoaged skin: 5 years results with intense pulsed light of the face, neck, and chest. Dermatol Surg 2002;28:1115–9. doi: + + + Alster TS, Tanzi E. Improvement of neck and cheek laxity with a nonablative radiofrequency device: a lifting experience. Dermatol Surg 2004;30:503–7. discussion 507. doi: + + + Seo KY, Kim DH, Lee SE, Yoon MS, Lee HJ. Skin rejuvenation by microneedle fractional radiofrequency and a human stem cell conditioned medium in Asian skin: a randomized controlled investigator blinded split-face studyRetraction in. J Cosmet Laser Therj Cosmet Laser Ther 20132020;1522:25–33. PMID: 23368685. doi: + + + Ashique KT, Kaliyadan F, Ruth George R. Dermabrasion in earlobe repair. J Am Acad Dermatol 2017;77:e105–e106. PMID: 28917474. doi: + + + Bastazini I Jr, Bastazini I, de Melo MCC, Peres CS, da Silva Biscarde EF. Surgical pearl: dermabrasion for the correction of incomplete cleft earlobe. J Am Acad Dermatol 2005;52:688–9. doi: + + + +
+ + + 36809177 + + 2023 + 02 + 22 + +
+ + 1940-1574 + + + 2023 + Feb + 21 + + + Angiology + Angiology + + Percutaneous Coronary Intervention Offers Clinical Benefits to Diabetic Patients With Stable Chronic Total Occlusion. + + 33197231153246 + + 10.1177/00033197231153246 + + Whether percutaneous coronary intervention for chronic total occlusion (CTO-PCI) in diabetic patients offers more benefits compared with initial medical therapy (CTO-MT) is unclear. In this study, diabetic patients with one CTO (clinical manifestations: stable angina or silent ischemia) were enrolled. Consecutively, enrolled patients (n = 1605) were assigned to different groups: CTO-PCI (1044 [65.0%]) and initial CTO-MT (561 [35%]). After a median follow-up of 44 months, CTO-PCI tended to be superior to initial CTO-MT in major adverse cardiovascular events (adjusted hazard-ratio [aHR]: .81, 95% conference-interval: .65-1.02) and significantly superior in cardiac death (aHR: .58 [.39-.87]) and all-cause death (aHR: .678[.473-.970]). Such superiority mainly attributed to a successful CTO-PCI. CTO-PCI tended to be performed in patients with younger age, good collaterals, left anterior descending branch CTO, and right coronary artery CTO. While, those with left circumflex CTO and severe clinical/angiographic situations were more likely to be assigned to initial CTO-MT. However, none of these variables influenced the benefits of CTO-PCI. Thus, we concluded that for diabetic patients with stable CTO, CTO-PCI (mainly successful CTO-PCI) offered patients survival benefits over initial CTO-MT. These benefits were consistent regardless of clinical/angiographic characteristics. + + + + Yan + Yunfeng + Y + + 12667Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Beijing, China. + + + + Yuan + Fei + F + + 12667Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Beijing, China. + + + + Liu + Xinmin + X + + 12667Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Beijing, China. + + + + Luo + Taiyang + T + + 12667Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Beijing, China. + + + + Feng + Xu + X + + 12667Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Beijing, China. + + + + Yao + Jing + J + + 12667Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Beijing, China. + + + + Zhang + Mingduo + M + + 12667Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Beijing, China. + + + + Gu + Feifei + F + + Department of Cardiology, Emergency General Hospital, Beijing, China. + + + + Song + Guangyuan + G + + 12667Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Beijing, China. + + + + Lyu + Shuzheng + S + 0000-0002-4243-2341 + + 12667Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Beijing, China. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Angiology + 0203706 + 0003-3197 + + IM + + chronic total occlusion + diabetes + medical therapy + percutaneous coronary intervention + +
+ + + + 2023 + 2 + 22 + 13 + 34 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809177 + 10.1177/00033197231153246 + + +
+ + + 36809185 + + 2023 + 02 + 22 + +
+ + 1365-2346 + + + 2023 + Feb + 22 + + + European journal of anaesthesiology + Eur J Anaesthesiol + + The effect of dexamethasone on biomarkers of inflammation and neuronal damage in patients with hip fracture: A secondary analysis of a randomised controlled trial. + 10.1097/EJA.0000000000001810 + + + Kluger + Michal + M + + From the Department of Anaesthesiology and Perioperative Medicine, Te Whatu Ora Waitematā (MK, MS, JC), Health and Rehabilitation Research Institute Auckland University of Technology (DR, PM), AUT-Roche Diagnostics Laboratory, Auckland University of Technology (FM, KA, JR, SH), Auckland, New Zealand. + + + + Skarin + Monica + M + + + Collier + Jill + J + + + Rice + David + D + + + Merien + Fabrice + F + + + Almeida + Katia + K + + + Ross + Jordan + J + + + Hogan + Saraya + S + + + McNair + Peter + P + + + eng + + Journal Article + + + 2023 + 02 + 22 + +
+ + England + Eur J Anaesthesiol + 8411711 + 0265-0215 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 34 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809185 + 10.1097/EJA.0000000000001810 + 00003643-990000000-00067 + + + + Clemmesen CG, Tavenier J, Andersen O, et al. Methylprednisolone and inflammatory stress response in older people undergoing surgery for hip fracture: a secondary analysis of a randomized controlled trial. Eur Geriatr Med 2019; 10:913–921. + + + Kluger MT, Skarin M, Collier J, et al. Steroids to reduce the impact on delirium (STRIDE): a double-blind, randomised, placebo-controlled feasibility trial of preoperative dexamethasone in people with hip fracture. Anaesthesia 2021; 76:1031–1041. + + + Saribal D, Hocaoglu-Emre FS, Erdogan S, et al. Inflammatory cytokines IL-6 and TNF-alpha in patients with hip fracture. Osteoporos Int 2019; 30:1025–1031. + + + Vosoughian M, Dahi M, Dabir S, et al. Effects of general anesthesia versus spinal anesthesia on serum cytokine release after cesarean section: a randomized clinical trial. Anesth Pain Med 2021; 11:e111272. + + + Alhayyan A, McSorley S, Roxburgh C, et al. The effect of anesthesia on the postoperative systemic inflammatory response in patients undergoing surgery: a systematic review and meta-analysis. Surg Open Sci 2020; 2:1–21. + + + Clemmesen CG, Lunn TH, Kristensen MT, et al. Effect of a single preoperative 125 mg dose of methylprednisolone on postoperative delirium in hip fracture patients; a randomised, double-blind, placebo-controlled trial. Anaesthesia 2018; 73:1353–1360. + + + +
+ + + 36809183 + + 2023 + 02 + 22 + +
+ + 1940-5200 + + + 2023 + Feb + 20 + + + Journal of correctional health care : the official journal of the National Commission on Correctional Health Care + J Correct Health Care + + Implementing Opt-Out HIV Testing in the Alameda County Jails. + 10.1089/jchc.20.05.0032 + + Incorporating routine opt-out HIV testing in correctional settings is a critical component of an effective strategy to end the HIV/AIDS epidemic. Between 2012 and 2017, Alameda County jails implemented opt-out HIV testing to identify new cases, link those who were newly diagnosed to care, and reengage those who were previously diagnosed but not in care. Over a 6-year period, 15,906 tests were conducted, with a positivity rate of 0.55% for both newly diagnosed cases and previously diagnosed but out of care. Nearly 80% of those who tested positive were linked to care within 90 days. The high positivity and successful linkage and reengagement with care underscores the need to support HIV testing programs in correctional settings. + + + + Feld + Samantha + S + + Sonoma County Probation Department, Santa Rosa, California, USA. + + + + Steele + Jessica + J + + Uplift Family Services, Campbell, California, USA. + + + + Klinedinst + Shailey + S + + Cardea Services, Oakland, California, USA. + + + + Delgadillo + Holvis + H + + Alameda County Santa Rita Jail, Oakland, California, USA. + + + + Garcia + Jonathan + J + + Alameda County Santa Rita Jail, Oakland, California, USA. + + + + Hinojosa + Lorenzo + L + + Alameda County Public Health, Office of HIV Prevention, Oakland, California, USA. + + + + Winters + Amanda + A + 0000-0002-8620-6418 + + Cardea Services, Seattle, Washington, USA. + + + + eng + + Journal Article + + + 2023 + 02 + 20 + +
+ + United States + J Correct Health Care + 9503759 + 1078-3458 + + IM + + HIV testing + correctional setting + jail + linkage to care + reengagement with care + +
+ + + + 2023 + 2 + 22 + 13 + 34 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809183 + 10.1089/jchc.20.05.0032 + + +
+ + + 36809178 + + 2023 + 02 + 22 + +
+ + 1741-2889 + + + 2023 + Feb + 21 + + + Journal of child health care : for professionals working with children in the hospital and community + J Child Health Care + + Children and young people's participation in decision-making within healthcare organisations in New Zealand: An integrative review. + + 13674935231153430 + + 10.1177/13674935231153430 + + There is a paucity of literature on children and young people's participation in decision-making within healthcare organisations in New Zealand. This integrative review examined child self-reported peer-reviewed manuscripts and published guidelines, policy, reviews, expert opinion and legislation to explore how New Zealand children and young people participate in discussions and decision-making processes within healthcare settings and what are barriers and benefits to such participation. Four child self-reported peer-reviewed manuscripts and twelve expert opinion documents were retrieved from four electronic databases including academic, government and institutional websites. Inductive content thematic analysis generated one theme (a discourse in children and young people's participation within healthcare settings), four sub-themes, 11 categories, 93 codes and 202 findings. It is evident within this review that there is a discourse between what expert opinion are stating is required to promote children and young people's participation in discussions and decision-making processes within healthcare settings and what is occurring in practice. Despite literature reporting on how children and young people's participation and voice were essential for healthcare provision, there was sparse literature published on children and young people's participation in discussions and decision-making processes in healthcare delivery in New Zealand. + + + + Foster + Mandie + M + 0000-0002-3100-0885 + + School of Clinical Sciences, 1410Auckland University of Technology, Auckland, New Zealand. + + + School of Nursing and Midwifery, Edith Cowan University, Perth, WA, Australia. + + + Child and Youth Health Research Centre, 1410AUT, Auckland, New Zealand. + + + + Blamires + Julie + J + 0000-0002-8515-1769 + + School of Clinical Sciences, 1410Auckland University of Technology, Auckland, New Zealand. + + + Child and Youth Health Research Centre, 1410AUT, Auckland, New Zealand. + + + + Moir + Chris + C + + Child and Youth Health Research Centre, 1410AUT, Auckland, New Zealand. + + + Centre for Postgraduate Nursing Studies, 2494University of Otago, Christchurch, New Zealand. + + + + Jones + Virginia + V + + Child and Youth Health Research Centre, 1410AUT, Auckland, New Zealand. + + + Centre for Postgraduate Nursing Studies, 2494University of Otago, Christchurch, New Zealand. + + + + Shrestha-Ranjit + Jagamaya + J + 0000-0001-9240-5555 + + School of Clinical Sciences, 1410Auckland University of Technology, Auckland, New Zealand. + + + Child and Youth Health Research Centre, 1410AUT, Auckland, New Zealand. + + + + Fenton + Brie + B + + School of Clinical Sciences, 1410Auckland University of Technology, Auckland, New Zealand. + + + Child and Youth Health Research Centre, 1410AUT, Auckland, New Zealand. + + + + Dickinson + Annette + A + + School of Clinical Sciences, 1410Auckland University of Technology, Auckland, New Zealand. + + + Child and Youth Health Research Centre, 1410AUT, Auckland, New Zealand. + + + + eng + + Journal Article + Review + + + 2023 + 02 + 21 + +
+ + England + J Child Health Care + 9806360 + 1367-4935 + + + child advocacy + children’s participation + children’s rights + determination of healthcare needs + healthcare systems + +
+ + + + 2023 + 2 + 22 + 13 + 34 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809178 + 10.1177/13674935231153430 + + +
+ + + 36809174 + + 2023 + 02 + 22 + +
+ + 2156-535X + + + 2023 + Feb + 21 + + + Journal of adolescent and young adult oncology + J Adolesc Young Adult Oncol + + Do Fertility Preservation Outcomes in Patients Diagnosed with Lymphoma Differ Based on Cancer Stage? + 10.1089/jayao.2022.0069 + + Purpose: This study aims to investigate whether oocyte stimulation outcomes in fertility preservation (FP) vary in patients with different stages of lymphoma. Methods: This is a retrospective cohort study conducted at Northwestern Memorial Hospital (NMH). Between 2006 and 2017, 89 patients were identified with a diagnosis of lymphoma who contacted the FP navigator at NMH. Anti-müllerian hormone (AMH) levels and FP ovarian stimulation outcomes were collected for analysis. The data were analyzed using chi-squared and analysis of variance tests. A regression analysis was also done to adjust for potential confounding variables. Results: Of the 89 patients who contacted the FP navigator, there were 12 patients (13.5%) with stage 1 lymphoma, 43 patients (48.3%) with stage 2, 13 patients (14.6%) with stage 3, 13 patients (14.6%) with stage 4, and 8 patients (9.0%) where staging information was not available. Forty-five of the patients proceeded with ovarian stimulation before initiating cancer treatment. Patients who underwent ovarian stimulation had a mean AMH level of 2.62 and median peak estradiol levels of 1772.0 pg/mL. Median oocytes retrieved was 16.77, mature oocytes were 11.00 and median oocytes frozen after completing FP was 8.00. These measures were also stratified by stage of lymphoma. Conclusion: We found no significant difference in number of retrieved, mature or vitrified oocytes between different cancer stages. There was also no difference in AMH levels in the different cancer stage groups. This suggests that even in higher stages of lymphoma, many patients respond to ovarian stimulation techniques and have a successful stimulation cycle. + + + + Kocsuta + Victoria + V + + Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. + + + + Shah + Shriya + S + + Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. + + + + Lawson + Angela K + AK + + Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. + + + + Pavone + Mary Ellen + ME + 0000-0002-4181-5543 + + Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + J Adolesc Young Adult Oncol + 101543508 + 2156-5333 + + IM + + controlled ovarian hyperstimulation + cryopreservation + fertility preservation + lymphoma + +
+ + + + 2023 + 2 + 22 + 13 + 34 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809174 + 10.1089/jayao.2022.0069 + + +
+ + + 36809176 + + 2023 + 02 + 22 + +
+ + 1522-1547 + + + 2023 + Feb + 21 + + + American journal of physiology. Gastrointestinal and liver physiology + Am J Physiol Gastrointest Liver Physiol + + Spatial response of jejunal pacing defined by a novel high-resolution multi-electrode array. + 10.1152/ajpgi.00258.2022 + + Gastric pacing has shown preclinical success in modulating bioelectrical slow wave activity and has potential as a novel therapy for functional motility disorders. However, the translation of pacing techniques to the small intestine remains preliminary. This paper presents the first high-resolution framework for simultaneous pacing and response mapping of the small intestine. + A novel surface-contact electrode array, capable of simultaneous pacing and high-resolution mapping of the pacing response was developed and applied in vivo on the proximal jejunum of pigs. Pacing parameters including the input energy and pacing electrode orientation were systematically evaluated and the efficacy of pacing was determined by analyzing spatiotemporal characteristics of entrained slow waves. Histological analysis was conducted to determine if the pacing resulted in tissue damage. + A total of 54 studies were conducted on 11 pigs and pacemaker propagation patterns were successfully achieved at both low (2 mA, 50 ms) and high (4 mA, 100 ms) energy levels with the pacing electrodes oriented in the antegrade, retrograde and circumferential directions. The high energy level performed significantly better (p=0.014) in achieving spatial entrainment. Comparable success (greater than 70%) was achieved when pacing in the circumferential and antegrade pacing directions, and no tissue damage was observed at the pacing sites. + This study defined the spatial response of small intestine pacing in vivo revealing effective pacing parameters for slow wave entrainment in the jejunum. Intestinal pacing now awaits translation to restore disordered slow wave activity associated with motility disorders. + + + + Nagahawatte + Nipuni D + ND + + Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand. + + + + Avci + Recep + R + + Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand. + + + + Paskaranandavadivel + Niranchan + N + + Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand. + + + + Angeli-Gordon + Timothy R + TR + + Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand. + + + Department of Surgery, University of Auckland, Auckland, New Zealand. + https://ror.org/03b94tp07 + + + + Cheng + Leo K + LK + + Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand. + + + Department of Surgery, Vanderbilt University, Nashville, TN, United States. + + + Riddet Institute Centre of Research Excellence, Palmerston North, New Zealand. + + + + eng + + + University of Auckland + + + + Manatu Hauora | Health Research Council of New Zealand (HRC) + + + + Royal Society of New Zealand | Marsden Fund (Royal Society of New Zealand Marsden Fund) + + + + Riddet Institute (The Riddet Institute) + + + + Royal Society Te Apārangi (Royal Society of New Zealand) + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Am J Physiol Gastrointest Liver Physiol + 100901227 + 0193-1857 + + IM + + electroceuticals + electrode + pacing + small intestine + stimulation + +
+ + + + 2023 + 2 + 22 + 13 + 34 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809176 + 10.1152/ajpgi.00258.2022 + + +
+ + + 36809181 + + 2023 + 02 + 22 + +
+ + 1744-8328 + + + 2023 + Feb + 21 + + + Expert review of anticancer therapy + Expert Rev Anticancer Ther + + Breakthrough cancer pain in the radiotherapy setting: a systematic and critical review. + 10.1080/14737140.2023.2182773 + + Breakthrough pain (BP) is a complex phenomenon that has been reported to have a relevant role in the global management of cancer pain. Radiotherapy (RT) has a fundamental part in the treatment of many pain conditions, particularly oral mucositis and painful bone metastases. + The literature regarding the phenomenon of BP in the radiotherapy setting was reviewed. Three areas were assessed, including epidemiology, pharmacokinetics, and clinical data. + Qualitative and quantitative data regarding BP in the RT setting are poor in terms of scientific evidence. Most papers assessed fentanyl products, particularly fentanyl pectin nasal spray, to resolve possible problems with transmucosal absorption of fentanyl due to mucositis of the oral cavity in patients with head and neck cancer or to prevent and treat procedural pain during RT sessions. According to the lack of clinical studies with large number of patients, BP should be included in the agenda of radiation oncologists. + + + + Mercadante + Sebastiano + S + + Main regional center for pain relief & palliative/supportive care, La Maddalena Cancer Center, via San Lorenzo 312, 90146 Palermo. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Expert Rev Anticancer Ther + 101123358 + 1473-7140 + + IM + + breakthrough pain + cancer pain + pain management + procedural pain + radiotherapy + +
+ + + + 2023 + 2 + 22 + 13 + 34 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809181 + 10.1080/14737140.2023.2182773 + + +
+ + + 36809175 + + 2023 + 02 + 22 + +
+ + 2561-326X + + 7 + + 2023 + Feb + 21 + + + JMIR formative research + JMIR Form Res + + Integrating User Preferences for Asthma Tools and Clinical Guidelines Into Primary Care Electronic Medical Records: Mixed Methods Study. + + e42767 + + 10.2196/42767 + + Asthma is a chronic respiratory disease that poses a substantial burden on individuals and the health care system. Despite published national guidelines for the diagnosis and management of asthma, considerable care gaps exist. Suboptimal adherence to asthma diagnosis and management guidelines contributes to poor patient outcomes. The integration of electronic tools (eTools) into electronic medical records (EMRs) represents a knowledge translation opportunity to support best practices. + The purpose of this study was to determine how best to integrate evidence-based asthma eTools into primary care EMRs across Ontario and Canada to improve adherence to guidelines as well as measure and monitor performance. + In total, 2 focus groups comprising physicians and allied health professionals who were considered experts in primary care, asthma, and EMRs were convened. One focus group also included a patient participant. Focus groups used a semistructured discussion-based format to consider the optimal methods for integrating asthma eTools into EMRs. Discussions were held on the web via Microsoft Teams (Microsoft Corp). The first focus group discussed integrating asthma indicators into EMRs using eTools, and participants completed a questionnaire evaluating the clarity, relevance, and feasibility of collecting asthma performance indicator data at the point of care. The second focus group addressed how to incorporate eTools for asthma into a primary care setting and included a questionnaire evaluating the perceived utility of various eTools. Focus group discussions were recorded and analyzed using thematic qualitative analysis. The responses to focus group questionnaires were assessed using descriptive quantitative analysis. + Qualitative analysis of the 2 focus group discussions revealed 7 key themes: designing outcome-oriented tools, gaining stakeholder trust, facilitating open lines of communication, prioritizing the end user, striving for efficiency, ensuring adaptability, and developing within existing workflows. In addition, 24 asthma indicators were rated according to clarity, relevance, feasibility, and overall usefulness. In total, 5 asthma performance indicators were identified as the most relevant. These included smoking cessation support, monitoring using objective measures, the number of emergency department visits and hospitalizations, assessment of asthma control, and presence of an asthma action plan. The eTool questionnaire responses revealed that the Asthma Action Plan Wizard and Electronic Asthma Quality of Life Questionnaire were perceived to be the most useful in primary care. + Primary care physicians, allied health professionals, and patients consider that eTools for asthma care present a unique opportunity to improve adherence to best-practice guidelines in primary care and collect performance indicators. The strategies and themes identified in this study can be leveraged to overcome barriers associated with asthma eTool integration into primary care EMRs. The most beneficial indicators and eTools, along with the key themes identified, will guide future asthma eTool implementation. + ©Max Moloney, Madison MacKinnon, Emma Bullock, Alison Morra, David Barber, Samir Gupta, John A Queenan, Geneviève C Digby, Teresa To, M Diane Lougheed. Originally published in JMIR Formative Research (https://formative.jmir.org), 21.02.2023. + + + + Moloney + Max + M + https://orcid.org/0000-0003-2293-910X + + Asthma Research Unit, Kingston Health Sciences Centre, Kingston, ON, Canada. + + + Division of Respirology, Department of Medicine, Queen's University, Kingston, ON, Canada. + + + + MacKinnon + Madison + M + https://orcid.org/0000-0002-5041-0249 + + Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. + + + + Bullock + Emma + E + https://orcid.org/0000-0003-0453-8433 + + Asthma Research Unit, Kingston Health Sciences Centre, Kingston, ON, Canada. + + + Division of Respirology, Department of Medicine, Queen's University, Kingston, ON, Canada. + + + + Morra + Alison + A + https://orcid.org/0000-0002-4904-9978 + + Asthma Research Unit, Kingston Health Sciences Centre, Kingston, ON, Canada. + + + Division of Respirology, Department of Medicine, Queen's University, Kingston, ON, Canada. + + + + Barber + David + D + https://orcid.org/0000-0001-8057-2153 + + Canadian Primary Care Sentinel Surveillance Network, Kingston, ON, Canada. + + + Department of Family Medicine, Queen's University, Kingston, ON, Canada. + + + + Gupta + Samir + S + https://orcid.org/0000-0002-7307-6247 + + Division of Respirology, Department of Medicine, St Michael's Hospital, Toronto, ON, Canada. + + + Department of Medicine, University of Toronto, Toronto, ON, Canada. + + + + Queenan + John A + JA + https://orcid.org/0000-0003-3248-6685 + + Department of Family Medicine, Queen's University, Kingston, ON, Canada. + + + + Digby + Geneviève C + GC + https://orcid.org/0000-0002-1858-0387 + + Division of Respirology, Department of Medicine, Queen's University, Kingston, ON, Canada. + + + + To + Teresa + T + https://orcid.org/0000-0001-7463-3423 + + Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. + + + Child Health Evaluative Science, The Hospital for Sick Children, Toronto, ON, Canada. + + + + Lougheed + M Diane + MD + https://orcid.org/0000-0001-6387-8759 + + Asthma Research Unit, Kingston Health Sciences Centre, Kingston, ON, Canada. + + + Division of Respirology, Department of Medicine, Queen's University, Kingston, ON, Canada. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Canada + JMIR Form Res + 101726394 + 2561-326X + + + asthma + electronic medical records + knowledge translation + qualitative analysis + quality improvement + +
+ + + + 2022 + 09 + 16 + + + 2023 + 01 + 12 + + + 2023 + 01 + 11 + + + 2023 + 2 + 22 + 13 + 34 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809175 + v7i1e42767 + 10.2196/42767 + + +
+ + + 36809180 + + 2023 + 02 + 22 + +
+ + 1476-8259 + + + 2023 + Feb + 21 + + + Computer methods in biomechanics and biomedical engineering + Comput Methods Biomech Biomed Engin + + Assessment of a two-mass ground reaction force model applied to indoor overground running in adult recreational runners. + + 1-12 + + 10.1080/10255842.2023.2178846 + + Outdoor running kinetic measurements like vertical ground reaction force (vGRF) need simple and accurate models. A previous study assessed a two mass model (2MM) on an athletic adult population during treadmill running, but not recreational adults during overground running. The objectives were to compare accuracy of the overground 2MM and an optimized version to the reference study and force platform (FP) measurements. Overground vGRF, ankle position, and running speed were collected on 20 healthy subjects in a laboratory. The subjects ran at three self-selected speeds and with an opposite foot strike strategy. Reconstructed 2MM vGRF curves were calculated with the original parameter values (Model1), with parameters optimized each strike (ModelOpt), and with group-based optimal parameters (Model2). Root mean square error (RMSE), optimized parameters, and ankle kinematics were compared to the reference study; peak force and loading rate were compared to FP measurements. The original 2MM showed decreased accuracy with overground running. ModelOpt overall RMSE was lower than Model1 (p > 0.001, d = 3.4). ModelOpt overall peak force was different but most like FP signals (p < 0.01, d = 0.7) and Model1 was most different (p < 0.001, d = 1.3). ModelOpt overall loading rate was similar to FP signals and Model1 was different (p < 0.001, d = 2.1). Optimized parameters were different (p < 0.001) from the reference study. 2MM accuracy was largely attributable to curve parameter choice. These may be dependent on extrinsic factors like running surface and protocol and intrinsic factors like age and athletic caliber. Rigorous validation is needed if the 2MM is to be used in the field. + + + + Kraszewski + Andrew P + AP + + Department of Rehabilitation, Leon Root, MD Motion Analysis Laboratory, Hospital for Special Surgery, New York, NY, USA. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Comput Methods Biomech Biomed Engin + 9802899 + 1025-5842 + + IM + + Accuracy + impulse + kinetics + optimization + +
+ + + + 2023 + 2 + 22 + 13 + 34 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809180 + 10.1080/10255842.2023.2178846 + + +
+ + + 36809184 + + 2023 + 02 + 22 + +
+ + 1741-7899 + + + 2023 + Feb + 01 + + + Reproduction (Cambridge, England) + Reproduction + + Hypoxia-mediated chemotaxis and residence of macrophage in decidua by secreting VEGFA and CCL2 during normal pregnancy. + 10.1530/REP-22-0473 + REP-22-0473 + + Infiltration and residence of decidual macrophage (dM) are of great significance to pregnancy maintenance for its role in angiogenesis, placental development and inducing immune tolerance. Besides, hypoxia has now been acknowledged as an important biological event at maternal-fetal interface in the first trimester. However, whether and how hypoxia regulates biofunctions of dM remains elusive. Herein, we observed increased expression of C-C motif chemokine ligand 2 (CCL2) and residence of macrophages in decidua when comparing to secretory-phase endometrium. Moreover, hypoxia treatment on stromal cells improved migration and adhesion of dM. Mechanistically, these effects might be mediated by upregulated CCL2 and adhesion molecules (especially ICAM2 and ICAM5) on stromal cells in the presence of endogenous vascular endothelial growth factor-A (VEGFA) in hypoxia. These findings were also verified by recombinant VEGFA and indirect coculture, indicating the interaction between stromal cells and dM in hypoxia condition may facilitate dM recruitment and residence. In conclusion, VEGFA derived from hypoxic environment may manipulate CCL2/CCR2 and adhesion molecules to enhance the interactions between dM and stromal cells and thus contribute to the enrichment of macrophages in decidua during early normal pregnancy. + + + + Qin + Xue-Yun + XY + + X Qin, Hospital of Obstetrics and Gynecology, Fudan University Shanghai, Shanghai, China. + + + + Shen + Hui-Hui + HH + + H Shen, Hospital of Obstetrics and Gynecology, Fudan University Shanghai, Shanghai, China. + + + + Zhang + Xin-Yan + XY + + X Zhang, Hospital of Obstetrics and Gynecology, Fudan University Shanghai, Shanghai, China. + + + + Zhang + Xing + X + + X Zhang, Hospital of Obstetrics and Gynecology, Fudan University Shanghai, Shanghai, China. + + + + Xie + Feng + F + + F Xie, Hospital of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China. + + + + Wang + Wen-Jun + WJ + + W Wang, Hospital of Obstetrics and Gynecology, Fudan University Shanghai, Shanghai, China. + + + + Xiong + Yu + Y + + Y Xiong, Department of Obstetrics, Fudan University Shanghai, Shanghai, China. + + + + Mei + Jie + J + + J Mei, Department of Obstetrics and Gynecology, The Affiliated Hospital of Nanjing University Medicine School, Nanjing, China. + + + + Li + Ming-Qing + MQ + + M Li, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, China. + + + + eng + + Journal Article + + + 2023 + 02 + 01 + +
+ + England + Reproduction + 100966036 + 1470-1626 + + IM +
+ + + + 2022 + 12 + 15 + + + 2023 + 02 + 21 + + + 2023 + 2 + 22 + 13 + 34 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809184 + 10.1530/REP-22-0473 + REP-22-0473 + + +
+ + + 36809182 + + 2023 + 02 + 22 + +
+ + 2379-5077 + + + 2023 + Feb + 21 + + + mSystems + mSystems + + Consistent Stool Metagenomic Biomarkers Associated with the Response To Melanoma Immunotherapy. + + e0102322 + + 10.1128/msystems.01023-22 + + The human gut microbiome plays an important role in both health and disease. Recent studies have demonstrated a strong influence of the gut microbiome composition on the efficacy of cancer immunotherapy. However, available studies have not yet succeeded in finding reliable and consistent metagenomic markers that are associated with the response to immunotherapy. Therefore, the reanalysis of the published data may improve our understanding of the association between the composition of the gut microbiome and the treatment response. In this study, we focused on melanoma-related metagenomic data, which are more abundant than are data from other tumor types. We analyzed the metagenomes of 680 stool samples from 7 studies that were published earlier. The taxonomic and functional biomarkers were selected after comparing the metagenomes of patients showing different treatment responses. The list of selected biomarkers was also validated on additional metagenomic data sets that were dedicated to the influence of fecal microbiota transplantation on the response to melanoma immunotherapy. According to our analysis, the resulting cross-study taxonomic biomarkers included three bacterial species: Faecalibacterium prausnitzii, Bifidobacterium adolescentis, and Eubacterium rectale. 101 groups of genes were identified to be functional biomarkers, including those potentially involved in the production of immune-stimulating molecules and metabolites. Moreover, we ranked the microbial species by the number of genes encoding functionally relevant biomarkers that they contained. Thus, we put together a list of potentially the most beneficial bacteria for immunotherapy success. F. prausnitzii, E. rectale, and three species of bifidobacteria stood out as the most beneficial species, even though some useful functions were also present in other bacterial species. IMPORTANCE In this study, we put together a list of potentially the most beneficial bacteria that were associated with a responsiveness to melanoma immunotherapy. Another important result of this study is the list of functional biomarkers of responsiveness to immunotherapy, which are dispersed among different bacterial species. This result possibly explains the existing irregularities between studies regarding the bacterial species that are beneficial to melanoma immunotherapy. Overall, these findings can be utilized to issue recommendations for gut microbiome correction in cancer immunotherapy, and the resulting list of biomarkers might serve as a good stepping stone for the development of a diagnostic test that is aimed at predicting patients' responses to melanoma immunotherapy. + + + + Olekhnovich + Evgenii I + EI + 0000-0003-4899-342X + + Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russian Federation. + + + + Ivanov + Artem B + AB + 0000-0002-7997-0637 + + ITMO University, Saint Petersburg, Russian Federation. + + + + Babkina + Anna A + AA + + Moscow Institute of Physics and Technology, Moscow, Russian Federation. + + + + Sokolov + Arseniy A + AA + + Moscow Institute of Physics and Technology, Moscow, Russian Federation. + + + + Ulyantsev + Vladimir I + VI + 0000-0003-0802-830X + + ITMO University, Saint Petersburg, Russian Federation. + + + + Fedorov + Dmitry E + DE + 0000-0001-8468-7011 + + Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russian Federation. + + + + Ilina + Elena N + EN + 0000-0003-0130-5079 + + Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russian Federation. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + mSystems + 101680636 + 2379-5077 + + IM + + cancer immunotherapy + compositional data analysis + fecal transplantation + gut microbiota + melanoma + metagenomics + +
+ + + + 2023 + 2 + 22 + 13 + 34 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809182 + 10.1128/msystems.01023-22 + + +
+ + + 36809179 + + 2023 + 02 + 22 + +
+ + 2057-5858 + + 9 + 2 + + 2023 + Feb + + + Microbial genomics + Microb Genom + + Whole-genome-based characterization of Campylobacter jejuni from human patients with gastroenteritis collected over an 18 year period reveals increasing prevalence of antimicrobial resistance. + 10.1099/mgen.0.000941 + + Campylobacteriosis is the most common cause of acute gastrointestinal bacterial infection in Europe, with most infections linked to the consumption of contaminated food. While previous studies found an increasing rate of antimicrobial resistance (AMR) in Campylobacter spp. over the past decades, the investigation of additional clinical isolates is likely to provide novel insights into the population structure and mechanisms of virulence and drug resistance of this important human pathogen. Therefore, we combined whole-genome sequencing and antimicrobial-susceptibility testing of 340 randomly selected Campylobacter jejuni isolates from humans with gastroenteritis, collected in Switzerland over an 18 year period. In our collection, the most common multilocus sequence types (STs) were ST-257 (n=44), ST-21 (n=36) and ST-50 (n=35); the most common clonal complexes (CCs) were CC-21 (n=102), CC-257 (n=49) and CC-48 (n=33). High heterogeneity was observed among STs, with the most abundant STs recurring over the entire study period, while others were observed only sporadically. Source attribution based on ST assigned more than half of the strains to the 'generalist' category (n=188), 25  % as 'poultry specialist' (n=83), and only a few to 'ruminant specialist' (n=11) or 'wild bird' origin (n=9). The isolates displayed an increased frequency of AMR from 2003 to 2020, with the highest rates of resistance observed for ciprofloxacin and nalidixic acid (49.8 %), followed by tetracycline (36.9 %). Quinolone-resistant isolates carried chromosomal gyrA mutations T86I (99.4 %) and T86A (0.6 %), whereas tetracycline-resistant isolates carried tet(O) (79.8 %) or mosaic tetO/32/O (20.2 %) genes. A novel chromosomal cassette carrying several resistance genes, including aph(3')-III, satA and aad(6), and flanked by insertion sequence elements was detected in one isolate. Collectively, our data revealed an increasing prevalence of resistance to quinolones and tetracycline in C. jejuni isolates from Swiss patients over time, linked to clonal expansion of gyrA mutants and acquisition of the tet(O) gene. Investigation of source attribution suggests that infections are most likely related to isolates from poultry or generalist backgrounds. These findings are relevant to guide future infection prevention and control strategies. + + + + Ghielmetti + Giovanni + G + + Institute for Food Safety and Hygiene, Section of Veterinary Bacteriology, University of Zurich, Zurich, Switzerland. + + + Applied Microbiology Research, Department of Biomedicine, University of Basel, Basel, Switzerland. + + + + Seth-Smith + Helena M B + HMB + + Applied Microbiology Research, Department of Biomedicine, University of Basel, Basel, Switzerland. + + + Clinical Bacteriology and Mycology, University Hospital Basel, Basel, Switzerland. + + + Swiss Institute for Bioinformatics, Basel, Switzerland. + + + + Roloff + Tim + T + + Applied Microbiology Research, Department of Biomedicine, University of Basel, Basel, Switzerland. + + + Clinical Bacteriology and Mycology, University Hospital Basel, Basel, Switzerland. + + + Swiss Institute for Bioinformatics, Basel, Switzerland. + + + + Cernela + Nicole + N + + Institute for Food Safety and Hygiene, University of Zurich, Zurich, Switzerland. + + + + Biggel + Michael + M + + Institute for Food Safety and Hygiene, University of Zurich, Zurich, Switzerland. + + + + Stephan + Roger + R + + Institute for Food Safety and Hygiene, University of Zurich, Zurich, Switzerland. + + + + Egli + Adrian + A + + Applied Microbiology Research, Department of Biomedicine, University of Basel, Basel, Switzerland. + + + Clinical Bacteriology and Mycology, University Hospital Basel, Basel, Switzerland. + + + + eng + + Journal Article + +
+ + England + Microb Genom + 101671820 + 2057-5858 + + IM + + Campylobacter jejuni + Switzerland + antimicrobial resistance + chromosomal cassette + time-scaled phylogenetic analysis + whole-genome sequencing + +
+ + + + 2023 + 2 + 22 + 13 + 34 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809179 + 10.1099/mgen.0.000941 + + +
+ + + 36809186 + + 2023 + 02 + 22 + +
+ + 1748-880X + + + 2023 + Feb + 21 + + + The British journal of radiology + Br J Radiol + + T1 based oxygen-enhanced MRI in tumours; a scoping review of current research. + + 20220624 + + 10.1259/bjr.20220624 + + Oxygen-enhanced MRI (OE-MRI) or tissue oxygen-level dependent (TOLD) MRI is an imaging technique under investigation for its ability to quantify and map oxygen distributions within tumours. The aim of this study was to identify and characterise the research into OE-MRI for characterising hypoxia in solid tumours. + A scoping review of published literature was performed on the PubMed and Web of Science databases for articles published before 27th May 2022. Studies imaging solid tumours using proton-MRI to measure oxygen induced T1/R1 relaxation time/rate changes were included. Grey literature was searched from conference abstracts and active clinical trials. + 49 unique records met the inclusion criteria consisting of 34 journal articles and 15 conference abstracts. The majority of articles were pre-clinical studies (31 articles) with 15 human only studies. Pre-clinical studies in a range of tumour types demonstrated consistent correlation of OE-MRI with alternative hypoxia measurements. No clear consensus on optimal acquisition technique or analysis methodology was found. No prospective, adequately powered, multicentre clinical studies relating OE-MRI hypoxia markers to patient outcomes were identified. + There is good preclinical evidence of the utility of OE-MRI in tumour hypoxia assessment however there are significant gaps in clinical research that need to be addressed to develop OE-MRI into a clinically applicable tumour hypoxia imaging technique. + The evidence base of OE-MRI in tumour hypoxia assessment is presented along with a summary of the research gaps to be addressed to transform OE-MRI derived parameters into tumour hypoxia biomarkers. + + + + McCabe + Alastair + A + 0000-0002-8691-7690 + + Academic Unit of Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, United Kingdom. + + + Department of Clinical Oncology, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom. + + + + Martin + Stewart + S + + Academic Unit of Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, United Kingdom. + + + + Shah + Jagrit + J + + Department of Radiology, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom. + + + + Morgan + Paul S + PS + + Mental Health & Clinical Neurosciences Unit, School of Medicine, University of Nottingham, Nottingham, United Kingdom. + + + Department of Medical Physics & Clinical Engineering, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom. + + + + Panek + Rafal + R + + Mental Health & Clinical Neurosciences Unit, School of Medicine, University of Nottingham, Nottingham, United Kingdom. + + + Department of Medical Physics & Clinical Engineering, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Br J Radiol + 0373125 + 0007-1285 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 35 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809186 + 10.1259/bjr.20220624 + + +
+ + + 36809190 + + 2023 + 02 + 22 + +
+ + 1559-8519 + + + 2023 + Feb + 21 + + + Journal of sex research + J Sex Res + + Effects of Ginger on Disgust, Sexual Arousal, and Sexual Engagement: A Placebo-Controlled Experiment. + + 1-13 + + 10.1080/00224499.2023.2175191 + + Sexual problems are common complaints across countries and cultures, and behavioral immune system theory suggests disgust plays an essential role in sexual functioning. The current study investigated 1) if disgust induced by sexual body fluids would reduce sexual arousal, reduce the likelihood of sexual engagement, and enhance disgust toward subsequent erotic stimuli, and 2) if the administration of ginger would affect these reactions. We administered either ginger or placebo pills to a sample of 247 participants (Mage = 21.59, SD = 2.52; 122 women) and asked them to complete either behavioral approach tasks with sexual body fluids or with neutral fluids. Next, participants viewed and responded to questions concerning erotic stimuli (nude and seminude pictures of opposite-sex models). As expected, the sexual body fluids tasks induced disgust. The elevated disgust induced by sexual body fluids tasks resulted in lower sexual arousal in women, whereas ginger consumption counteracted this inhibiting effect of disgust on sexual arousal. Disgust elicited by sexual body fluids also increased disgust toward the subsequent erotic stimuli. Ginger increased sexual arousal toward the erotic stimuli in both men and women who had completed the neutral fluids tasks. Findings provide further evidence of the role of disgust in sexual problems, and, importantly, that ginger may improve the sexual function of individuals via its sexual arousal-enhancing effect. + + + + Wen + Guangju + G + 0000-0001-6514-9146 + + School of Psychology and Cognitive Science, East China Normal University. + + + Faculty of Arts and Sciences, NYU Shanghai. + + + + Zhang + Yikang + Y + 0000-0001-5173-562X + + Faculty of Psychology and Neuroscience, Maastricht University. + + + NYU-ECNU Institute for Social Development, NYU Shanghai. + + + + Nyman + Thomas J + TJ + 0000-0002-6409-2528 + + Faculty of Arts and Sciences, NYU Shanghai. + + + + Jern + Patrick + P + 0000-0001-9044-7604 + + Department of Psychology, Åbo Akademi University. + + + + Santtila + Pekka + P + 0000-0002-0459-1309 + + School of Psychology and Cognitive Science, East China Normal University. + + + Faculty of Arts and Sciences, NYU Shanghai. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + J Sex Res + 0062647 + 0022-4499 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 35 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809190 + 10.1080/00224499.2023.2175191 + + +
+ + + 36809189 + + 2023 + 02 + 22 + +
+ + 1522-1504 + + + 2023 + Feb + 21 + + + American journal of physiology. Lung cellular and molecular physiology + Am J Physiol Lung Cell Mol Physiol + + Mucociliary Clearance Augmenting Drugs Block SARS-Cov-2 Replication in Human Bronchial Epithelial Cells. + 10.1152/ajplung.00285.2022 + + The coronavirus disease (COVID-19) pandemic, caused by SARS-CoV-2 coronavirus, is devastatingly impacting human health. A prominent component of COVID-19 is the infection and destruction of the ciliated respiratory cells, which perpetuates dissemination and disrupts protective mucociliary transport (MCT) function, an innate defense of the respiratory tract. Thus, drugs that augment MCT could improve barrier function of the airway epithelium, reduce viral replication and, ultimately, COVID-19 outcomes. We tested five agents known to increase MCT through distinct mechanisms for activity against SARS-CoV-2 infection using a model of human respiratory epithelial cells terminally differentiated in an air/liquid interphase. Three of the five mucoactive compounds tested showed significant inhibitory activity against SARS-CoV-2 replication. An archetype mucoactive agent, ARINA-1, blocked viral replication and therefore epithelial cell injury, thus, it was further studied using biochemical, genetic and biophysical methods to ascertain mechanism of action via improvement of MCT. ARINA-1 antiviral activity was dependent on enhancing the MCT cellular response, since terminal differentiation, intact ciliary expression and motion was required for ARINA-1-mediated anti-SARS-CoV2 protection. Ultimately, we showed that improvement of cilia movement was caused by ARINA-1-mediated regulation of the redox state of the intracellular environment, which benefited MCT. Our study indicates that Intact MCT reduces SARS-CoV-2 infection, and its pharmacologic activation may be effective as an anti-COVID-19 treatment. + + + + Campos-Gomez + Javier + J + + Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States. + https://ror.org/008s83205 + + + Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL, United States. + https://ror.org/008s83205 + + + + Fernandez Petty + Courtney + C + + Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States. + https://ror.org/008s83205 + + + + Mazur + Marina + M + + Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States. + https://ror.org/008s83205 + + + Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL, United States. + https://ror.org/008s83205 + + + + Tang + Liping + L + + Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States. + https://ror.org/008s83205 + + + Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL, United States. + https://ror.org/008s83205 + + + + Solomon + George M + GM + + Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States. + https://ror.org/008s83205 + + + Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL, United States. + https://ror.org/008s83205 + + + + Joseph + Reny + R + + Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States. + https://ror.org/008s83205 + + + Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL, United States. + https://ror.org/008s83205 + + + + Li + Qian + Q + + Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States. + https://ror.org/008s83205 + + + Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL, United States. + https://ror.org/008s83205 + + + + Lever + Jacelyn E Peabody + JEP + + Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States. + https://ror.org/008s83205 + + + Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL, United States. + https://ror.org/008s83205 + + + Medical Scientist Training Program, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States. + https://ror.org/008s83205 + + + + Hussain + Shah Saddad + SS + + Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States. + https://ror.org/008s83205 + + + + Harrod + Kevin S + KS + + Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States. + https://ror.org/008s83205 + + + Department of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, AL, United States. + https://ror.org/008s83205 + + + + Onuoha + Ezinwanne E + EE + + Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, United States. + https://ror.org/008s83205 + + + + Kim + Harrison + H + + Department of Radiology, University of Alabama at Birmingham, Birmingham, AL, United States. + https://ror.org/008s83205 + + + + Rowe + Steven M + SM + + Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States. + https://ror.org/008s83205 + + + Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL, United States. + https://ror.org/008s83205 + + + + eng + + + R35 HL135816-04S1 + Foundation for the National Institutes of Health (FNIH) + + + + P30DK072482-12 + Foundation for the National Institutes of Health (FNIH) + + + + 5F31HL146083-02 + Foundation for the National Institutes of Health (FNIH) + + + + 3T32GM008361-30S1 + Foundation for the National Institutes of Health (FNIH) + + + + 2T32HL105346-11A1 + Foundation for the National Institutes of Health (FNIH) + + + + PHILLI20G0 + Cystic Fibrosis Foundation (CFF) + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Am J Physiol Lung Cell Mol Physiol + 100901229 + 1040-0605 + + IM + + Mucociliary transport + SARS-CoV-2 + antioxidant + cilia movement + mucoactive drug + +
+ + + + 2023 + 2 + 22 + 13 + 35 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809189 + 10.1152/ajplung.00285.2022 + + +
+ + + 36809191 + + 2023 + 02 + 22 + +
+ + 2192-5682 + + + 2023 + Feb + 21 + + + Global spine journal + Global Spine J + + Is Minimally Invasive Bipolar Technique a Better Alternative to Long Fusion for Adult Neuromuscular Scoliosis? + + 21925682231159347 + + 10.1177/21925682231159347 + + Prospective cohort study. + To report the results for an alternative technique based on minimally invasive fusion-less surgery. This approach is original in that it corrects deformities by proximal and distal fixation, with reliable pelvic fixation through the use of iliosacral screws on osteoporotic bones. + Adult cerebral palsy patients requiring spinal correction surgery were included prospectively between 2015 and 2019. The technique involved the use of a double-rod construct anchored proximally by four clawed hooks and distally by iliosacral screws, in a minimally invasive approach. Cobb angle and pelvic obliquity were measured before and after initial surgery and at final follow-up. Complications and functional results were reviewed. This group (P) was compared with a second group (R) of patients who underwent surgery between 2005 and 2015, for whom data were collected retrospectively. + Thirty-one patients were included in group P, and 15 in group R. The two groups were comparable for demographic data and deformity. At most recent follow-up (3 years for group P [2-6] and 5 years for group R [2-16]), neither correction nor surgical complications differed between the two groups. However, group P had 50% less blood loss and a lower medical complication rate than group R. + Our results confirm the effectiveness of this minimally invasive technique for neuromuscular scoliosis in adults. The results were similar to those obtained with the usual techniques, but with fewer medical complications. Confirmation of these results is now required for a longer follow-up period. + + + + Wolff + Stéphane + S + + Service de Chirurgie Orthopédique, 55662Groupe Hospitalier Paris Saint-Joseph, Paris, France. + + + + Moreau + Pierre-Emmanuel + PE + + Service de Chirurgie Orthopédique, 55662Groupe Hospitalier Paris Saint-Joseph, Paris, France. + + + + Miladi + Lotfi + L + + Assistance Publique des Hôpitaux de Paris, 246596Hôpital Necker Enfants Malades, Paris, France. + + + + Riouallon + Guillaume + G + 0000-0003-4499-621X + + Service de Chirurgie Orthopédique, 55662Groupe Hospitalier Paris Saint-Joseph, Paris, France. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Global Spine J + 101596156 + 2192-5682 + + + adult spinal deformity + bipolar technique + fusion-less surgery + iliosacral screws + minimally invasive technique + neuromuscular scoliosis + +
+ + + + 2023 + 2 + 22 + 13 + 35 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809191 + 10.1177/21925682231159347 + + +
+ + + 36809196 + + 2023 + 02 + 22 + +
+ + 2325-8306 + + + 2023 + Feb + 20 + + + LGBT health + LGBT Health + + Sexual Orientation Disparities in Depression and Substance Use Among Adults: Results from the Brazilian National Health Survey 2019. + 10.1089/lgbt.2022.0193 + + Purpose: We compared the prevalence of depression, hazardous alcohol use, daily tobacco use and hazardous alcohol and tobacco use (HATU) by sexual orientation and sex among Brazilian adults. Methods: Data were obtained from a national health survey conducted in 2019. This study included participants aged 18 years and older (N = 85,859). Adjusted prevalence ratios (APRs) and confidence intervals were estimated using Poisson regression models stratified by sex to examine the association between sexual orientation, depression, daily tobacco use, hazardous alcohol use, and HATU. Results: After controlling for the covariates, gay men showed a higher prevalence of depression, daily tobacco use, and HATU compared with heterosexual men (APR ranged from 1.71 to 1.92). Furthermore, bisexual men showed a higher prevalence (almost three times) of depression compared with heterosexual men. Lesbian women showed a higher prevalence of binge and heavy drinking, daily tobacco use, and HATU compared with heterosexual women (APR ranged from 2.55 to 4.44). Among bisexual women, the results were significant for all analyzed outcomes (APR ranged from 1.83 to 3.26). Conclusions: This study was the first to use a nationally representative survey to assess sexual orientation disparities related to depression and substance use by sex in Brazil. Our findings highlight the need for specific public policies aimed at the sexual minority population and for greater recognition and better management of these disorders by health professionals. + + + + L Gomes + Nayara + N + 0000-0001-9743-9850 + + Department of Epidemiology, Institute of Social Medicine, State University of Rio de Janeiro, Rio de Janeiro, Brazil. + + + Department of Study, Methods and Control, Brazilian Institute of Geography and Statistics, Rio de Janeiro, Brazil. + + + + S Lopes + Claudia + C + + Department of Epidemiology, Institute of Social Medicine, State University of Rio de Janeiro, Rio de Janeiro, Brazil. + + + + eng + + Journal Article + + + 2023 + 02 + 20 + +
+ + United States + LGBT Health + 101616707 + 2325-8292 + + IM + + Brazil + adults + depression + health disparities + sexual orientation + substance use/abuse + +
+ + + + 2023 + 2 + 22 + 13 + 35 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809196 + 10.1089/lgbt.2022.0193 + + +
+ + + 36809194 + + 2023 + 02 + 22 + +
+ + 1557-8100 + + + 2023 + Feb + 20 + + + Omics : a journal of integrative biology + OMICS + + Can Water-Only DNA Extraction Reduce the Logistical Footprint of Biosurveillance and Planetary Health Diagnostics? Toward a New Method. + 10.1089/omi.2022.0168 + + The coronavirus disease-2019 (COVID-19) pandemic has raised the stakes for planetary health diagnostics. Because pandemics pose enormous burdens on biosurveillance and diagnostics, reduction of the logistical burdens of pandemics and ecological crises is essential. Moreover, the disruptive effects of catastrophic bioevents impact the supply chains in both highly populated urban centers and rural communities. One "upstream" focus of methodological innovation in biosurveillance is the footprint of Nucleic Acid Amplification Test (NAAT)-based assays. We report in this study a water-only DNA extraction, as an initial step in developing future protocols that may require few expendables, and with low environmental footprints, in terms of wet and solid laboratory waste. In the present work, boiling-hot distilled water was used as the main cell lysis agent for direct polymerase chain reactions (PCRs) on crude extracts. After evaluation (1) in blood and mouth swabs for human biomarker genotyping, and (2) in mouth swabs and plant tissue for generic bacterial or fungal detection, and using different combinations of extraction volume, mechanical assistance, and extract dilution, we found the method to be applicable in low-complexity samples, but not in high-complexity ones such as blood and plant tissue. In conclusion, this study examined the doability of a lean approach for template extraction in the case of NAAT-based diagnostics. Testing our approach with different biosamples, PCR settings, and instruments, including portable ones for COVID-19 or dispersed applications, warrant further research. Minimal resources analysis is a concept and practice, vital and timely for biosurveillance, integrative biology, and planetary health in the 21st century. + + + + Goudoudaki + Stavroula + S + + ELGO-Demeter, Plant Protection Division of Patras, Patras, Greece. + + + + Kambouris + Manousos E + ME + 0000-0002-3205-4797 + + Department of Pharmacy, School of Health Sciences, University of Patras, Patras, Greece. + + + + Siamoglou + Stavroula + S + + Department of Pharmacy, School of Health Sciences, University of Patras, Patras, Greece. + + + + Gioula + Georgia + G + + Microbiology Department, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. + + + + Kantzanou + Maria + M + + Department of Microbiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece. + + + + Manoussopoulou + Marianna + M + + ELGO-Demeter, Plant Protection Division of Patras, Patras, Greece. + + + Department of Agronomics, Food, Natural Resources, Animals and Environment, University of Padua, Padua, Italy. + + + + Patrinos + George P + GP + 0000-0002-0519-7776 + + Department of Pharmacy, School of Health Sciences, University of Patras, Patras, Greece. + + + Department of Genetics and Genomics, and Zayed Center for Health Sciences, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates. + + + + Manoussopoulos + Yiannis + Y + + ELGO-Demeter, Plant Protection Division of Patras, Patras, Greece. + + + + eng + + Journal Article + + + 2023 + 02 + 20 + +
+ + United States + OMICS + 101131135 + 1536-2310 + + IM + + COVID-19 + biosurveillance + ecology + minimal resource analysis + one health + pandemic + +
+ + + + 2023 + 2 + 22 + 13 + 35 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809194 + 10.1089/omi.2022.0168 + + +
+ + + 36809204 + + 2023 + 02 + 22 + +
+ + 1537-1611 + + 24 + 3 + + 2023 + Mar + 01 + + + Journal of clinical neuromuscular disease + J Clin Neuromuscul Dis + + Guillain-Barre Syndrome After the Third BNT162b2 Dose in an Adolescent Without Side Effects After the First and Second Jab. + + 162-163 + + 10.1097/CND.0000000000000434 + + + Finsterer + Josef + J + + Neurology & Neurophysiology Center, Vienna, Austria. + + + + eng + + Journal Article + +
+ + United States + J Clin Neuromuscul Dis + 100887391 + 1522-0443 + + IM + The author reports no conflicts of interest. +
+ + + + 2023 + 2 + 22 + 13 + 36 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809204 + 10.1097/CND.0000000000000434 + 00131402-202303000-00006 + + + + Finsterer J, Scorza FA, Scorza CA. Post SARS-CoV-2 vaccination Guillain-Barre syndrome in 19 patients. Clinics (Sao Paulo). 2021;76:e3286. + + + Shao SC, Wang CH, Chang KC, et al. Guillain-​Barré syndrome associated with COVID-19 vaccination. Emerg Infect Dis. 2021;27:3175–3178. + + + Chen Y, Xu Z, Wang P, et al. New-onset autoimmune phenomena post-COVID-19 vaccination. Immunology. 2022;165:386–401. + + + Miller ER, McNeil MM, Moro PL, et al. The reporting sensitivity of the vaccine adverse event reporting system (VAERS) for anaphylaxis and for guillain-barré syndrome. Vaccine. 2020;38:7458–7463. + + + Toljan K, Amin M, Kunchok A, Ontaneda D. New diagnosis of multiple sclerosis in the setting of mRNA COVID-19 vaccine exposure. J Neuroimmunology. 2022;362:577785. + + + +
+ + + 36809195 + + 2023 + 02 + 22 + +
+ + 2471-254X + + 7 + 3 + + 2023 + Mar + 01 + + + Hepatology communications + Hepatol Commun + + Impact of setanaxib on quality of life outcomes in primary biliary cholangitis in a phase 2 randomized controlled trial. + + e0057 + + 10.1097/HC9.0000000000000057 + + There is a real unmet need for primary biliary cholangitis (PBC) treatments that can improve quality of life impacting symptoms. In this post hoc analysis, we evaluated potential effects of the NADP oxidase 1/4 inhibitor, setanaxib, on patient-reported quality of life from a phase 2 trial in PBC. + The underpinning double-blind, randomized, placebo-controlled trial (NCT03226067) recruited 111 patients with PBC and inadequate response/intolerance to ursodeoxycholic acid. Patients self-administered oral placebo (n=37), setanaxib 400 mg once daily (OD; n=38), or setanaxib 400 mg twice daily (BID; n=36), in addition to ursodeoxycholic acid for 24 weeks. Quality of life outcomes were assessed using the validated PBC-40 questionnaire. Patients were stratified post hoc by baseline fatigue severity. + At week 24, patients treated with setanaxib 400 mg BID reported greater mean (SE) absolute reductions from baseline in PBC-40 fatigue domain score [-3.6 (1.3)] versus those receiving setanaxib 400 mg OD [-0.8 (1.0)]) or placebo [0.6 (0.9)]. Similar observations were made across all PBC-40 domains except itch. In the setanaxib 400 mg BID arm, patients with moderate-to-severe fatigue at baseline had a greater reduction in mean fatigue score at week 24 [-5.8 (2.1)] versus those with mild fatigue [-0.6 (0.9)]; results were similar across all domains. Reduced fatigue was correlated with emotional, social, symptom, and cognitive improvements. + These results support further investigation of setanaxib as a treatment for patients with PBC, particularly for those with clinically significant fatigue. + Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Association for the Study of Liver Diseases. + + + + Jones + David + D + 0000-0002-0083-5564 + + Newcastle University Medical School, Newcastle Upon Tyne, UK. + + + + Carbone + Marco + M + 0000-0003-1445-0443 + + Division of Gastroenterology, Department of Medicine and Surgery, Centre for Autoimmune Liver Diseases, University of Milano-Bicocca, Monza, Italy. + + + European Reference Network on Hepatological Diseases (ERN RARE-LIVER), San Gerardo Hospital, Monza, Italy. + + + + Invernizzi + Pietro + P + 0000-0003-3262-1998 + + Division of Gastroenterology, Department of Medicine and Surgery, Centre for Autoimmune Liver Diseases, University of Milano-Bicocca, Monza, Italy. + + + European Reference Network on Hepatological Diseases (ERN RARE-LIVER), San Gerardo Hospital, Monza, Italy. + + + + Little + Nicola + N + 0000-0002-7007-30 + + Calliditas Therapeutics AB, Stockholm, Sweden. + + + + Nevens + Frederik + F + 0000-0003-2905-5112 + + Department of Gastroenterology and Hepatology, University Hospital KU Leuven, Health Care Provider of the ERN RARE-LIVER, Leuven, Belgium. + + + + Swain + Mark G + MG + 0000-0002-0919-4468 + + University of Calgary Liver Unit, Calgary, Alberta, Canada. + + + + Wiesel + Philippe + P + 000-0001-7287-2703 + + Genkyotex, Geneva, Switzerland. + + + + Levy + Cynthia + C + 0000-0001-5498-6037 + + Schiff Center for Liver Diseases, University of Miami, Florida, USA. + + + + eng + + Journal Article + + + 2023 + 02 + 20 + +
+ + United States + Hepatol Commun + 101695860 + 2471-254X + + IM +
+ + + + 2022 + 09 + 02 + + + 2022 + 12 + 04 + + + 2023 + 2 + 22 + 13 + 35 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809195 + 10.1097/HC9.0000000000000057 + 02009842-202303010-00020 + + + + Lleo A, Leung PSC, Hirschfield GM, Gershwin EM. The pathogenesis of primary biliary cholangitis: a comprehensive review. Semin Liver Dis. 2020;40:34–48. + + + Rannard A, Buck D, Jones DE, James OF, Jacoby A. Assessing quality of life in primary biliary cirrhosis. Clin Gastroenterol Hepatol. 2004;2:164–74. + + + Onofrio FQ, Hirschfield GM, Gulamhusein AF. A practical review of primary biliary cholangitis for the gastroenterologist. Gastroenterol Hepatol (N Y). 2019;15:145–54. + + + Purohit T, Cappell MS. Primary biliary cirrhosis: pathophysiology, clinical presentation and therapy. World J Hepatol. 2015;7:926–41. + + + Jin XY, Khan TM. Quality of life among patients suffering from cholestatic liver disease-induced pruritus: a systematic review. J Formos Med Assoc. 2016;115:689–702. + + + Hirschfield GM, Dyson JK, Alexander GJM, Chapman MH, Collier J, Hübscher S, et al. The British Society of Gastroenterology/UK-PBC primary biliary cholangitis treatment and management guidelines. Gut. 2018;67:1568–94. + + + Selmi C, Gershwin ME, Lindor KD, Worman HJ, Gold EB, Watnik M, et al. Quality of life and everyday activities in patients with primary biliary cirrhosis. Hepatology. 2007;46:1836–43. + + + Nevens F, Andreone P, Mazzella G, Strasser SI, Bowlus C, Invernizzi P, et al. A placebo-controlled trial of obeticholic acid in primary biliary cholangitis. N Engl J Med. 2016;375:631–43. + + + Lindor KD, Bowlus CL, Boyer J, Levy C, Mayo M. Primary biliary cholangitis: 2018 practice guidance from the American Association for the Study of Liver Diseases. Hepatology. 2019;69:394–419. + + + Phaw NA, Dyson JK, Mells G, Jones D. Understanding fatigue in primary biliary cholangitis. Dig Dis Sci. 2021;66:2380–6. + + + Hegade VS, Mells GF, Fisher H, Kendrick S, DiBello J, Gilchrist K, et al. Pruritus is common and undertreated in patients with primary biliary cholangitis in the United Kingdom. Clin Gastroenterol Hepatol. 2019;17:1379.e1373. + + + Khanna A, Hegade VS, Jones DE. Management of fatigue in primary biliary cholangitis. Curr Hepatol Rep. 2019;18:127–33. + + + Lindor KD, Dickson ER, Baldus WP, Jorgensen RA, Ludwig J, Murtaugh PA, et al. Ursodeoxycholic acid in the treatment of primary biliary cirrhosis. Gastroenterology. 1994;106:1284–90. + + + Heathcote EJ, Cauch-Dudek K, Walker V, Bailey RJ, Blendis LM, Ghent CN, et al. The Canadian multicenter double-blind randomized controlled trial of ursodeoxycholic acid in primary biliary cirrhosis. Hepatology. 1994;19:1149–56. + + + Combes B, Carithers RL, Maddrey WC, Lin D, McDonald MF, Wheeler DE, et al. A randomized, double-blind, placebo-controlled trial of ursodeoxycholic acid in primary biliary cirrhosis. Hepatology. 1995;22:759–66. + + + Hirschfield GM, Mason A, Luketic V, Lindor K, Gordon SC, Mayo M, et al. Efficacy of obeticholic acid in patients with primary biliary cirrhosis and inadequate response to ursodeoxycholic acid. Gastroenterology. 2015;148:751.e758. + + + Rudic JS, Poropat G, Krstic MN, Bjelakovic G, Gluud C. Ursodeoxycholic acid for primary biliary cirrhosis. Cochrane Database Syst Rev. 2012;12:CD000551. + + + Food and Drug Administration. Highlights of prescribing information: Ocaliva® (obeticholic acid). Accessed June 2022. https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/207999s007lbl.pdf + + + De Vries E, Bolier R, Goet J, Parés A, Verbeek J, De Vree M, et al. Fibrates for itch (FITCH) in fibrosing cholangiopathies: a double-blind, randomized, placebo-controlled trial. Gastroenterology. 2021;160:734.e736. + + + Corpechot C, Chazouillères O, Rousseau A, Le Gruyer A, Habersetzer F, Mathurin P, et al. A placebo-controlled trial of bezafibrate in primary biliary cholangitis. N Engl J Med. 2018;378:2171–81. + + + Kremer AE, Mayo MJ, Hirschfield G, Levy C, Bowlus CL, Jones DE, et al. Seladelpar improved measures of pruritus, sleep, and fatigue and decreased serum bile acids in patients with primary biliary cholangitis. Liver Int. 2022;42:112–23. + + + Huang J, Invernizzi P, Dalekos G, Nevens F, Van Vlierberghe H, Zigmond E, et al. The NOX1/4 inhibitor GKT831 achieves clinically meaningful reductions in liver stiffness, attenuates cholestasis, and improves quality of life in patients with primary biliary cholangitis [Abstract]. Hepatology. 2019;70(suppl):777A–8A. + + + ClinicalTrials.gov. Study to Assess Safety & Efficacy of GKT137831 in Patients With Primary Biliary Cholangitis Receiving Ursodiol. Accessed October 25, 2022. https://clinicaltrials.gov/ct2/show/NCT03226067 + + + Newton JL, Hudson M, Tachtatzis P, Sutcliffe K, Pairman J, Burt JA, et al. Population prevalence and symptom associations of autonomic dysfunction in primary biliary cirrhosis. Hepatology. 2007;45:1496–505. + + + Corpechot C, Carrat F, Poujol-Robert A, Gaouar F, Wendum D, Chazouillères O, et al. Noninvasive elastography-based assessment of liver fibrosis progression and prognosis in primary biliary cirrhosis. Hepatology. 2012;56:198–208. + + + Lammers WJ, van Buuren HR, Hirschfield GM, Janssen HL, Invernizzi P, Mason AL, et al. Levels of alkaline phosphatase and bilirubin are surrogate end points of outcomes of patients with primary biliary cirrhosis: an international follow-up study. Gastroenterology. 2014;147:1338.e1335. + + + Jacoby A, Rannard A, Buck D, Bhala N, Newton J, James O, et al. Development, validation, and evaluation of the PBC-40, a disease specific health related quality of life measure for primary biliary cirrhosis. Gut. 2005;54:1622–9. + + + Jopson L, Newton JL, Palmer J, Floudas A, Isaacs J, Qian J, et al. RITPBC: B-cell depleting therapy (rituximab) as a treatment for fatigue in primary biliary cirrhosis: study protocol for a randomised controlled trial. BMJ Open. 2015;5:e007985. + + + Khanna A, Jopson L, Howel D, Bryant A, Blamire A, Newton JL, et al. Rituximab is ineffective for treatment of fatigue in primary biliary cholangitis: a phase 2 randomized controlled trial. Hepatology. 2019;70:1646–57. + + + Overholser BR, Sowinski KM. Biostatistics primer: part 2. Nutr Clin Pract. 2008;23:76–84. + + + Lee JY, Danford CJ, Trivedi HD, Tapper EB, Patwardhan VR, Bonder A. Treatment of fatigue in primary biliary cholangitis: a systematic review and meta-analysis. Dig Dis Sci. 2019;64:2338–50. + + + Newton JL, Bhala N, Burt J, Jones DE. Characterisation of the associations and impact of symptoms in primary biliary cirrhosis using a disease specific quality of life measure. J Hepatol. 2006;44:776–83. + + + Kaps L, Grambihler A, Yemane B, Nagel M, Labenz C, Ploch P, et al. Symptom burden and treatment response in patients with primary biliary cholangitis (PBC). Dig Dis Sci. 2020;65:3006–13. + + + Carbone M, Bufton S, Monaco A, Griffiths L, Jones DE, Neuberger JM. The effect of liver transplantation on fatigue in patients with primary biliary cirrhosis: a prospective study. J Hepatol. 2013;59:490–94. + + + Swain MG, Jones DEJ. Fatigue in chronic liver disease: new insights and therapeutic approaches. Liver Int. 2019;39:6–19. + + + Pal R, Basu Thakur P, Li S, Minard C, Rodney GG. Real-time imaging of NADPH oxidase activity in living cells using a novel fluorescent protein reporter. PLoS One. 2013;8:e63989. + + + Kumar D, Tandon RK. Fatigue in cholestatic liver disease--a perplexing symptom. Postgrad Med J. 2002;78:404–7. + + + Quarneti C, Muratori P, Lalanne C, Fabbri A, Menichella R, Granito A, et al. Fatigue and pruritus at onset identify a more aggressive subset of primary biliary cirrhosis. Liver Int. 2015;35:636–41. + + + Jones DE, Al-Rifai A, Frith J, Patanwala I, Newton JL. The independent effects of fatigue and UDCA therapy on mortality in primary biliary cirrhosis: results of a 9 year follow-up. J Hepatol. 2010;53:911–7. + + + Mells GF, Pells G, Newton JL, Bathgate AJ, Burroughs AK, Heneghan MA, et al. Impact of primary biliary cirrhosis on perceived quality of life: the UK-PBC national study. Hepatology. 2013;58:273–83. + + + Jones D, Carlsson S, von Reedtz S, Levy C. A phase 2b/3 randomized, placebo-controlled, double-blind trial for treatment of primary biliary cholangitis (PBC) with setanaxib: objectives and study design [Abstract]. Hepatology. 2022;76(S1):S1461–S1462; Abstract 4700. + + + +
+ + + 36809205 + + 2023 + 02 + 22 + +
+ + 1537-1611 + + 24 + 3 + + 2023 + Mar + 01 + + + Journal of clinical neuromuscular disease + J Clin Neuromuscul Dis + + Complex Repetitive Discharges Seen in Polymyalgia Rheumatica. + + 163-164 + + 10.1097/CND.0000000000000427 + + + Skolka + Michael P + MP + + Department of Neurology, Mayo Clinic, Rochester, MN. + + + + Laughlin + Ruple S + RS + + + eng + + Journal Article + +
+ + United States + J Clin Neuromuscul Dis + 100887391 + 1522-0443 + + IM + The authors report no conflicts of interest. +
+ + + + 2023 + 2 + 22 + 13 + 36 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809205 + 10.1097/CND.0000000000000427 + 00131402-202303000-00007 + + + + Rubin DI. Normal and abnormal spontaneous activity. Handb Clin Neurol. 2019;160:257–279. + + + Fellows LK, Foster BJ, Chalk CH. Clinical significance of complex repetitive discharges: a case-control study. Muscle Nerve. 2003;28:504–507. + + + Trontelj J, Stålberg E. Bizarre repetitive discharges recorded with single fibre EMG. J Neurol Neurosurg Psychiatry. 1983;46:310–316. + + + Castañeda S, García-Castañeda N, Prieto-Peña D, et al. Treatment of polymyalgia rheumatica. Biochem Pharmacol. 2019;165:221–229. + + + Douglass-Molloy H, Limaye V. Prevalence of polymyalgia rheumatica in a cohort of patients with idiopathic inflammatory myopathy. Clin Rheumatol. 2020;39:1217–1221. + + + +
+ + + 36809197 + + 2023 + 02 + 22 + +
+ + 1748-880X + + + 2023 + Feb + 21 + + + The British journal of radiology + Br J Radiol + + Stereotactic radiation therapy for oligometastatic esophagogastric adenocarcinoma: outcome and prognostic factors. + + 20220771 + + 10.1259/bjr.20220771 + + The aim of this study was to evaluate clinical results and prognostic factors in a cohort of patient with oligometastatic esophagogastric adenocarcinoma treated with Stereotactic Radiation Therapy (SRT). + This retrospective study included patients affected by 1 to 3 metastases treated with SRT from 2013 to 2021. Local control (LC), overall survival (OS), progression free survival (PFS), time to polymetastatic dissemination (TTPD) and time to systemic therapy change/initiation (TTS) were evaluated. + Between 2013 and 2021, 55 patients were treated with SRT on 80 oligometastatic sites. Median follow-up was 20 months. Nine patients had local progression. 1 and 3 years LC was respectively 92 and 78%. 41 patients experienced further distant disease progression, median PFS was 9.6 months, 1 and 3 years PFS was respectively 40 and 15%. 34 patients died, median OS was 26.6 months, 1 and 3 years OS was respectively 78 and 40%. During follow up, 24 patients changed or initiated a new systemic therapy; median TTS time was 9 months. Twenty-seven patients experienced poliprogression, 44% after 1 year and 52% after 3 years. Median TTPD was 8 months. The best local response (LR), tyming of metastases and PS were related with prolonged PFS on multivariate analysis. LR was correlated with OS at multivariate analysis. + SRT represents a valid treatment for oligometastatic esophagogastric adenocarcinoma. CR correlated with PFS and OS, while metachronous metastasis and a good PS correlated with a better PFS. + In selected gastroesopagheal oligometastatic patients, SRT can prolong OSLocal response to SRT, metachronous timing of metastases and better PS improve PFSLocal response correlates with OS. + + + + Franceschini + Davide + D + 0000-0003-1142-2439 + + Department of Radiotherapy and Radiosurgery, IRCCS Humanitas Research Hospital, Via Manzoni, Rozzano, Milan, Italy. + + + + Teriaca + Maria Ausilia + MA + + Department of Radiotherapy and Radiosurgery, IRCCS Humanitas Research Hospital, Via Manzoni, Rozzano, Milan, Italy. + + + + Di Cristina + Luciana + L + + Department of Radiotherapy and Radiosurgery, IRCCS Humanitas Research Hospital, Via Manzoni, Rozzano, Milan, Italy. + + + Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy. + + + + Vernier + Veronica + V + + Department of Radiotherapy and Radiosurgery, IRCCS Humanitas Research Hospital, Via Manzoni, Rozzano, Milan, Italy. + + + Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy. + + + + Lo Faro + Lorenzo + L + + Department of Radiotherapy and Radiosurgery, IRCCS Humanitas Research Hospital, Via Manzoni, Rozzano, Milan, Italy. + + + Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy. + + + + Franzese + Ciro + C + + Department of Radiotherapy and Radiosurgery, IRCCS Humanitas Research Hospital, Via Manzoni, Rozzano, Milan, Italy. + + + Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy. + + + + Comito + Tiziana + T + + Department of Radiotherapy and Radiosurgery, IRCCS Humanitas Research Hospital, Via Manzoni, Rozzano, Milan, Italy. + + + + Clerici + Elena + E + + Department of Radiotherapy and Radiosurgery, IRCCS Humanitas Research Hospital, Via Manzoni, Rozzano, Milan, Italy. + + + + Bellu + Luisa + L + + Department of Radiotherapy and Radiosurgery, IRCCS Humanitas Research Hospital, Via Manzoni, Rozzano, Milan, Italy. + + + + Dominici + Luca + L + + Department of Radiotherapy and Radiosurgery, IRCCS Humanitas Research Hospital, Via Manzoni, Rozzano, Milan, Italy. + + + + Spoto + Ruggero + R + + Department of Radiotherapy and Radiosurgery, IRCCS Humanitas Research Hospital, Via Manzoni, Rozzano, Milan, Italy. + + + + Massaro + Maria + M + + Department of Radiotherapy and Radiosurgery, IRCCS Humanitas Research Hospital, Via Manzoni, Rozzano, Milan, Italy. + + + + Navarria + Piera + P + + Department of Radiotherapy and Radiosurgery, IRCCS Humanitas Research Hospital, Via Manzoni, Rozzano, Milan, Italy. + + + + Scorsetti + Marta + M + + Department of Radiotherapy and Radiosurgery, IRCCS Humanitas Research Hospital, Via Manzoni, Rozzano, Milan, Italy. + + + Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Br J Radiol + 0373125 + 0007-1285 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 35 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809197 + 10.1259/bjr.20220771 + + +
+ + + 36809203 + + 2023 + 02 + 22 + +
+ + 1537-1611 + + 24 + 3 + + 2023 + Mar + 01 + + + Journal of clinical neuromuscular disease + J Clin Neuromuscul Dis + + Characteristics of Peripheral Neuropathy in Patients With Livedoid Vasculopathy. + + 157-161 + + 10.1097/CND.0000000000000435 + + Livedoid vasculopathy (LV) is an ulcerative disorder of the lower extremities characterized by dermal vessel thrombosis with unclear cause. Recent reports of LV-associated upper extremity peripheral neuropathy and epineurial thrombosis suggest a systemic etiology for the condition. We sought to outline the characteristics of peripheral neuropathy in patients with LV. Cases of LV with concurrent peripheral neuropathy and reviewable electrodiagnostic testing reports were identified by electronic medical record database query and examined in detail. Of 53 patients with LV, 33 (62%) had peripheral neuropathy, 11 had reviewable electrodiagnostic reports, and 6 had no clear alternative explanation for neuropathy. Distal symmetric polyneuropathy was the most commonly observed pattern of neuropathy (n = 3) followed by mononeuropathy multiplex (n = 2). Most patients experienced symptoms in both upper and lower extremities (n = 4). Peripheral neuropathy is common in patients with LV. Whether this association is reflective of a systemic, prothrombotic etiology remains to be determined. + Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved. + + + + Eswaran + Harish + H + + Department of Medicine, Division of Hematology, University of North Carolina School of Medicine, Chapel Hill, NC. + + + + Traub + Rebecca + R + + Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, NC. + + + + Googe + Paul + P + + Department of Dermatology, University of North Carolina School of Medicine, Chapel Hill, NC; and. + + + + Moll + Stephan + S + + Department of Medicine, Division of Hematology, University of North Carolina School of Medicine, Chapel Hill, NC. + + + Blood Research Center, University of North Carolina School of Medicine, Chapel Hill, NC. + + + + eng + + Journal Article + +
+ + United States + J Clin Neuromuscul Dis + 100887391 + 1522-0443 + + IM + Dr. Traub has received research funding from Alnylam Pharmaceuticals, Ionis pharmaceuticals, Argenx, and Pharnext. The remaining authors report no conflicts of interest. +
+ + + + 2023 + 2 + 22 + 13 + 36 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809203 + 10.1097/CND.0000000000000435 + 00131402-202303000-00005 + + + + Schroeter AL, Diaz-Perez JL, Winkelmann RK, Jordan RE. Livedo vasculitis (the vasculitis of atrophie blanche). Immunohistopathologic study. Arch Dermatol. 1975;111:188–193. + + + Vasudevan B, Neema S, Verma R. Livedoid vasculopathy: a review of pathogenesis and principles of management. Indian J Dermatol Venereol Leprol. 2016;82:478–488. + + + Hairston BR, Davis MDP, Pittelkow MR, Ahmed I. Livedoid vasculopathy: further evidence for procoagulant pathogenesis. Arch Dermatol. 2006;142:1413–1418. + + + McCalmont CS, McCalmont TH, Jorizzo JL, et al. Livedo vasculitis: vasculitis or thrombotic vasculopathy? Clin Exp Dermatol. Clin Exp Dermatol. 1992;17:4–8. + + + Yang C-H, Shen S-C, Hui RC-Y, et al. Association between peripheral vascular endothelial dysfunction and livedoid vasculopathy. J Am Acad Dermatol. 2012;67:107–112. + + + Papi M, Didona B, De Pità O, et al. Livedo vasculopathy vs small vessel cutaneous vasculitis: cytokine and platelet P-selectin studies. Arch Dermatol. 1998;134:447–452. + + + Chow M, Swift R, Sutton A, Wysong A. Endovenous laser ablation treatment for lower extremity ulcers associated with livedoid vasculopathy. Dermatol Surg. 2020;46:853–854. + + + Soulages A, Maisonobe T, Auzou P, et al. Peripheral neuropathy and livedoid vasculopathy. J Neurol. 2022;269:3779–3788. + + + Allenbach Y, Tourte M, Stenzel W, et al. Expanding the spectrum of livedoid vasculopathy: peculiar neuromuscular manifestations. Neuropathol Appl Neurobiol. 2015;41:849–852. + + + Gardette E, Moguelet P, Bouaziz J-D, et al. Livedoid vasculopathy: a French observational study including therapeutic options. Acta Dermato Venereologica. 2018;98:842–847. + + + Reinhardt F, Wetzel T, Vetten S, et al. Peripheral neuropathy in chronic venous insufficiency. Muscle Nerve. 2000;23:883–887. + + + +
+ + + 36809200 + + 2023 + 02 + 22 + +
+ + 1537-1611 + + 24 + 3 + + 2023 + Mar + 01 + + + Journal of clinical neuromuscular disease + J Clin Neuromuscul Dis + + What Is in the Myopathy Literature? + + 130-139 + + 10.1097/CND.0000000000000440 + + This update begins with the results of a positive trial of intravenous immunoglobulin in dermatomyositis and a study of molecular and morphologic patterns in inclusion body myositis that may explain treatment refractoriness. Single center reports of muscular sarcoidosis and immune-mediated necrotizing myopathy follow. There is also a report of caveolae-associated protein 4 antibodies as a potential biomarker and cause of immune rippling muscle disease. The remainder covers updates on muscular dystrophies as well as congenital and inherited metabolic myopathies with an emphasis on genetic testing. Rare dystrophies, including one involving ANXA11 mutations and a series on oculopharyngodistal myopathy, are discussed. + Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved. + + + + Lacomis + David + D + + Departments of Neurology and Pathology (Neuropathology), University of Pittsburgh School of Medicine, Pittsburgh, PA. + + + + eng + + Journal Article + +
+ + United States + J Clin Neuromuscul Dis + 100887391 + 1522-0443 + + IM + The author reports no conflicts of interest. +
+ + + + 2023 + 2 + 22 + 13 + 36 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809200 + 10.1097/CND.0000000000000440 + 00131402-202303000-00002 + + + + Aggarwal R, Charles-Schoeman C, Schessl J, et al. Trial of intravenous immune globulin in dermatomyositis. N Engl J Med. 2022;387:1264–1278. + + + Kleefeld F, Uruha A, Schänzer A, et al. Morphologic and molecular patterns of polymyositis with mitochondrial pathology and inclusion body myositis. Neurology. 2022;99:e2212–e2222. + + + Praefcke GJK. Regulation of innate immune functions by guanylate-binding proteins. Int J Med Microbiol. 2018;308:237–245. + + + Greenberg SA, Pinkus JL, Kong SW, et al. Highly differentiated cytotoxic T cells in inclusion body myositis. Brain. 2019;142:2590–2604. + + + Britson KA, Ling JP, Braunstein KE, et al. Loss of TDP-43 function and rimmed vacuoles persist after T cell depletion in a xenograft model of sporadic inclusion body myositis. Sci Transl Med. 2022;14:eabi9196. + + + Greenberg SA. Inclusion body myositis: boundaries that may define transition to treatment refractoriness. Neurology. 2022;99:873–874. + + + Goel N, Soler-Ferran D, Coutreau M, et al. Depletion of KLRG1+ T cells in a first-in-human clinical trial of ABC008 in inclusion body myositis (IBM) [abstract]. Arthritis Rheumatol. 2021;(suppl 9):73. + + + NIH. Phase 1 Study of ABC008 in Adult Patients with Inclusion Body Myositis (IBM). 2022. Available at: https://clinicaltrials.gov/ct2/show/NCT04659031?cond=inclusion+body+myositis&draw=2&rank=1. Accessed December 8, 2022. + + + Chompoopong P, Liewluck T. Granulomatous myopathy: sarcoidosis and beyond. Muscle Nerve. 2022. Epub ahead of print. doi: 10.1002/mus.27741. + + 10.1002/mus.27741 + + + + Ten Dam L, Raaphorst J, van der Kooi AJ, et al. Clinical characteristics and outcome in muscular sarcoidosis: a retrospective cohort study and literature review. Neuromuscul Disord. 2022;32:557–563. + + + Wang JX, Wilkinson M, Oldmeadow C, et al. Outcome predictors of immune-mediated necrotizing myopathy-a retrospective, multicentre study. Rheumatology (Oxford). 2022;61:3824–3829. + + + Kocoloski A, Martinez S, Moghadam-Kia S, et al. Role of Intravenous Immunoglobulin in necrotizing autoimmune myopathy. J Clin Rheumatol. 2022;28:e517–e520. + + + Dubey D, Beecher G, Hammami MB, et al. Identification of caveolae-associated protein 4 autoantibodies as a biomarker of immune-mediated rippling muscle disease in adults. JAMA Neurol. 2022;79:808–816. + + + Wong WK, Bryen SJ, Bournazos A, et al. A genetic basis is identified in 74% cases of paediatric hyperCKaemia without weakness presenting to a tertiary paediatric neuromuscular centre. Neuromuscul Disord. 2022;32:707–717. + + + Fernandez C, de Paula AM, Figarella-Branger D, et al. Diagnostic evaluation of clinically normal subjects with chronic hyperCKemia. Neurology. 2006;66:1585–1587. + + + Simmons Z, Peterlin BL, Boyer PJ, et al. Muscle biopsy in the evaluation of patients with modestly elevated creatine kinase levels. Muscle Nerve. 2003;27:242–244. + + + Cabrera-Serrano M, Ravenscroft G. Recent advances in our understanding of genetic rhabdomyolysis. Curr Opin Neurol. 2022;35:651–657. + + + Kahraman AB, Karakaya B, Yıldız Y, et al. Two tales of LPIN1 deficiency: from fatal rhabdomyolysis to favorable outcome of acute compartment syndrome. Neuromuscul Disord. 2022;32:931–934. + + + Topf A, Johnson K, Bates A, et al. Sequential targeted exome sequencing of 1001 patients affected by unexplained limb‐girdle weakness. Genet Med. 2020;22:1478‐1488. + + + Krenn M, Tomschik M, Wagner M, et al. Clinico-genetic spectrum of limb-girdle muscular weakness in Austria: a multicentre cohort study. Eur J Neurol. 2022;29:1815–1824. + + + Johari M, Papadimas G, Papadopoulos C, et al. Adult-onset dominant muscular dystrophy in Greek families caused by Annexin A11. Ann Clin Transl Neurol. 2022;9:1660–1667. + + + Smith BN, Topp SD, Fallini C, et al. Mutations in the vesicular trafficking protein annexin A11 are associated with amyotrophic lateral sclerosis. Sci Transl Med. 2017;9:eaad9157. + + + Leoni TB, González‐Salazar C, Rezende TJR, et al. A novel multisystem proteinopathy caused by a missense ANXA11 variant. Ann Neurol. 2021;90:239‐252. + + + Satoyoshi E, Kinoshita M. Oculopharyngodistal myopathy. Arch Neurol. 1977;34:89–92. + + + Kumutpongpanich T, Liewluck T. Oculopharyngodistal myopathy: the recent discovery of an old disease. Muscle Nerve. 2022;66:650–652. + + + Ishiura H, Shibata S, Yoshimura J, et al. Noncoding CGG repeat expansions in neuronal intranuclear inclusion disease, oculopharyngodistal myopathy and an overlapping disease. Nat Genet. 2019;51:1222–1232. + + + Shimizu T, Ishiura H, Hara M, et al. Expanded clinical spectrum of oculopharyngodistal myopathy type 1. Muscle Nerve. 2022;66:679–685. + + + Yu J, Shan J, Yu M, et al. The CGG repeat expansion in RILPL1 is associated with oculopharyngodistal myopathy type 4. Am J Hum Genet. 2022;109:533–541. + + + Zeng YH, Yang K, Du GQ, et al. GGC repeat expansion of RILPL1 is associated with oculopharyngodistal myopathy. Ann Neurol. 2022;92:512–526. + + + Pinto MJ, Passos BA, Grangeia A, et al. Congenital myopathies in adults: a diagnosis not to overlook. Acta Neurol Scand. 2022;146:152–159. + + + +
+ + + 36809202 + + 2023 + 02 + 22 + +
+ + 1537-1611 + + 24 + 3 + + 2023 + Mar + 01 + + + Journal of clinical neuromuscular disease + J Clin Neuromuscul Dis + + Acute and Chronic Demyelinating Neuropathies After COVID-19 Vaccination: A Report of 4 Cases. + + 147-156 + + 10.1097/CND.0000000000000418 + + To report demyelinating neuropathies after COVID-19 vaccination. + Case report. + Four cases of demyelinating neuropathies after COVID-19 vaccination were identified at the University of Nebraska Medical Center from May to September 2021. Three were male and 1 was a female, ages 26-64 years. Three cases received Pfizer-BioNTech vaccine and 1 Johnson & Johnson. Symptom onset ranged from 2 to 21 days after vaccination. Two cases had progressive limb weakness, 3 had facial diplegia, and all had sensory symptoms and areflexia. The diagnosis was acute inflammatory demyelinating polyneuropathy in 1 case and chronic inflammatory demyelinating polyradiculoneuropathy in 3. All cases received treatment with intravenous immunoglobulin, with significant improvement in 3 of 4 who had a long-term outpatient follow-up. + Continued identification and reporting of cases of demyelinating neuropathies after COVID-19 vaccination is essential to determine whether a causative association is present. + Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved. + + + + Dennis + Erin + E + + Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE; and. + + + + Hartman + Elizabeth + E + + Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE; and. + + + + Cortes-Penfield + Nicolas + N + + Division of Infectious Diseases, University of Nebraska Medical Center, Omaha, NE. + + + + Piccione + Ezequiel + E + + Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE; and. + + + + Thaisetthawatkul + Pariwat + P + + Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE; and. + + + + eng + + Journal Article + +
+ + United States + J Clin Neuromuscul Dis + 100887391 + 1522-0443 + + IM + The authors report no conflicts of interest. +
+ + + + 2023 + 2 + 22 + 13 + 36 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809202 + 10.1097/CND.0000000000000418 + 00131402-202303000-00004 + + + + Koike H, Chiba A, Katsuno M. Emerging infection, vaccination, and Guillain-Barre syndrome: a review. Neurol Ther. 2021;12:1–15. + + + Yuki N, Hartung HP. Guillain-Barre syndrome. N Engl J Med. 2012;366:2294–2304. + + + Waheed S, Bayas A, Hindi F, et al. Neurological complications of COVID-19: Guillain-Barre syndrome following Pfizer COVID-19 vaccine. Cureus. 2021;13:e13426. + + + Maramottom BV, Krishnan P, Paul R, et al. Guillain-Barre syndrome following ChAdOx1-S/nCoV-19 vaccine. Ann Neurol. 2021;90:312–314. + + + Allen CM, Ramsamy S, Tarr AW, et al. Guillain-Barre syndrome variant occurring after SARS-CoV-2 vaccination. Ann Neurol. 2021;90:315–318. + + + Bonifacio GB, Patel D, Cook S, et al. Bilateral facial weakness and paresthesia variant of Guillain-Barre syndrome following Vaxzebria COVID-19 vaccine. J Neurol Neurosurg Psychiatry. 2021;93:341–342. + + + Nasuelli NA, De Marchi F, Cecchin M, et al. A case of acute demyelinating polyradiculoneuropathy with bilateral facial palsy after ChAdOx1 nCoV-19 vaccine. Neurol Sci. 2021;42:4747–4749. + + + Prasad A, Hurlburt G, Podury S, et al. A novel case of bifacial diplegia variant of Guillain-Barre syndrome following Janssen COVID-19 vaccination. Neurol Int. 2021;13:404–409. + + + Khayat-Khoei M, Bhattacharyya S, Katz J, et al. COVID-19 mRNA vaccination leading to CNS inflammation: a case series. J Neurol. 2021;269:1093–1106. + + + Wang W, Litchy WJ, Mauermann ML, et al. Blink R1 latency utility in diagnosis and treatment assessment of polyradiculoneuropathy-organomegaly-endocrinopathy-monoclonal protein-skin changes and chronic inflammatory demyelinating polyradiculoneuropathy. Muscle Nerve. 2018;57:E8–E13. + + + Doneddu PE, Bianchi E, Cocito D, et al. Risk factors for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): antecedent events, lifestyle and dietary habits; data from the Italian CIDP database. Eur J Neurol. 2020;27:136–143. + + + Nobile-Orazio E. Chronic inflammatory demyelinating polyradiculoneuropathy and variants: where we are and where we should go. J Peripher Nerv Syst. 2014;19:2–13. + + + Ayrignac X, Viala K, Koutlidis RM, et al. Sensory chronic inflammatory demyelinating polyneuropathy: an under-recognized entity? Muscle Nerve. 2013;48:727–732. + + + Abu-Rumeileh S, Garibashvili T, Ruf W, et al. Exacerbation of chronic inflammatory demyelinating polyneuropathy in concomitance with COVID-19. J Neurol Sci. 2020;418:117106. + + + Van Looy E, Veenker L, Steyaert A, et al. COVID-19- induced exacerbation of chronic inflammatory demyelinating polyneuropathy. J Neurol. 2021;268:3129–3131. + + + Rajabally YA, Peric S, Bozovic I, et al. Antecedent infections and vaccinations in chronic inflammatory demyelinating polyneuropathy: a European collaborative study. Muscle Nerve. 2021;64:657–661. + + + Lunn MP, Cornblath DR, Jacobs BC, et al. COVID-19 vaccine and Guillain-Barre syndrome: let's not leap to associations. Brain. 2021;144:357–360. + + + Marquez Loza AM, Holroyd KB, Johnson SA, et al. Guillain-Barre syndrome in the placebo and active arms of a COVID-19 vaccine clinical trial: temporal associations do not imply causality. Neurology. 2021. + + + Polack FP, Thomas SJ, Kitchin N, et al. C4591001 Clinical Trial Group. Safety and efficacy of the BNT162b2 mRNA COVID-19 vaccine. N Engl J Med. 2020;383:2603–2615. + + + Baden LR, El Sahly HM, Essink B, et al.; COVE Study GroupEfficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine. N Engl J Med. 2021;384:403–416. + + + Li X, Ostropolets A, Makadia R, et al. Characterizing the incidence of adverse events of special interest for COVID-19 vaccines across eight countries: a multinational network cohort study. BMJ. 2021;373:n1435. + + + Thakur KT, Epstein S, Bilski A, et al. Neurologic safety monitoring of COVID-19 vaccines: lessons from the past to inform the present. Neurology. 2021;97:767–775. + + + Patone M, Handunnetthi L, Saatci D, et al. Neurological complications after first dose of COVID-19 vaccines and SARS-CoV-2 infection. Nat Med. 2021;27:2144–2153. + + + Zivkovic SA, Gruener G, Narayanaswami P, et al. The AANEM Quality and Patient Safety Committee. Doctor- should I get the COVID-19 vaccine? Infection and immunization in individuals with neuromuscular disorders. Muscle Nerve. 2021;63:294–303. + + + Doneddu PE, Spina E, Briani C, et al. The Italian Peripheral Nervous System Association (ASNP). Acute and chronic inflammatory neuropathies and COVID-19 vaccines: practical recommendations from the task force of the Italian ASNP. J Peripher Nerv Sys. 2021;26:148–154. + + + +
+ + + 36809208 + + 2023 + 02 + 22 + +
+ + 1537-1611 + + 24 + 3 + + 2023 + Mar + 01 + + + Journal of clinical neuromuscular disease + J Clin Neuromuscul Dis + + Unilateral Facial Palsy After SARS-CoV-2 Booster Vaccination. + + 166-168 + + 10.1097/CND.0000000000000416 + + + Bains + Navpreet K + NK + + The Departments of Neurology, University of Missouri Columbia Medical Center, Columbia, MO. + + + + Attele + Dinanath Praveen + DP + 0000-0003-2222-1798 + + The Departments of Neurology, University of Missouri Columbia Medical Center, Columbia, MO. + + + + Qureshi + Adnan I + AI + + The Departments of Neurology, University of Missouri Columbia Medical Center, Columbia, MO. + + + Department of Neurology, Zeenat Qureshi Stroke Institute, St. Cloud, MN. + + + + eng + + Journal Article + +
+ + United States + J Clin Neuromuscul Dis + 100887391 + 1522-0443 + + IM + A. L. Qureshi has received an educational grant from KabaFusion. The remaining authors report no conflicts of interest. +
+ + + + 2023 + 2 + 22 + 13 + 36 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809208 + 10.1097/CND.0000000000000416 + 00131402-202303000-00010 + + + + Shemer A, Pras E, Einen-Lifshitz A, et al. Association of COVID-19 vaccination and facial nerve palsy—a case-control study. JAMA Otolaryngol Head Neck Surg. 2021;147:739–743. + + + Burrows A, Bartholomew T, Rudd J, et al. Sequential contralateral facial nerve palsies following COVID-19 vaccination first and second doses. BMJ Case Rep. 2021;14:e243829. + + + Yilmaz M, Tarakcioglu M, Bayazit N, et al. Serum cytokine levels in Bell's palsy. J Neurol Sci. 2002;197:69–72. + + + Greco A, Gallo A, Fusconi M, et al. Bell's palsy and autoimmunity. Autoimmun Rev. 2012;12:323–328. + + + REMAP-CAP. Effect of hydrocortisone on mortality and organ support in patients with severe COVID-19—the REMAP-CAP COVID-19 corticosteroid domain randomized clinical trial. JAMA. 2020;324:1317–1329. + + + +
+ + + 36809215 + + 2023 + 02 + 22 + +
+ + 1527-1315 + + + 2023 + Feb + 21 + + + Radiology + Radiology + + Prognostic Value of Cardiac MRI and FDG PET in Cardiac Sarcoidosis: A Systematic Review and Meta-Analysis. + + 222483 + + 10.1148/radiol.222483 + + Background There is no consensus regarding the relative prognostic value of cardiac MRI and fluorodeoxyglucose (FDG) PET in cardiac sarcoidosis. Purpose To perform a systematic review and meta-analysis of the prognostic value of cardiac MRI and FDG PET for major adverse cardiac events (MACE) in cardiac sarcoidosis. Materials and Methods In this systematic review, MEDLINE, Ovid Epub, CENTRAL, Embase, Emcare, and Scopus were searched from inception until January 2022. Studies that evaluated the prognostic value of cardiac MRI or FDG PET in adults with cardiac sarcoidosis were included. The primary outcome of MACE was assessed as a composite including death, ventricular arrhythmia, and heart failure hospitalization. Summary metrics were obtained using random-effects meta-analysis. Meta-regression was used to assess covariates. Risk of bias was assessed using the Quality in Prognostic Studies, or QUIPS, tool. Results Thirty-seven studies were included (3489 patients with mean follow-up of 3.1 years ± 1.5 [SD]); 29 studies evaluated MRI (2931 patients) and 17 evaluated FDG PET (1243 patients). Five studies directly compared MRI and PET in the same patients (276 patients). Left ventricular late gadolinium enhancement (LGE) at MRI and FDG uptake at PET were both predictive of MACE (odds ratio [OR], 8.0 [95% CI: 4.3, 15.0] [P < .001] and 2.1 [95% CI: 1.4, 3.2] [P < .001], respectively). At meta-regression, results varied by modality (P = .006). LGE (OR, 10.4 [95% CI: 3.5, 30.5]; P < .001) was also predictive of MACE when restricted to studies with direct comparison, whereas FDG uptake (OR, 1.9 [95% CI: 0.82, 4.4]; P = .13) was not. Right ventricular LGE and FDG uptake were also associated with MACE (OR, 13.1 [95% CI: 5.2, 33] [P < .001] and 4.1 [95% CI: 1.9, 8.9] [P < .001], respectively). Thirty-two studies were at risk for bias. Conclusion Left and right ventricular late gadolinium enhancement at cardiac MRI and fluorodeoxyglucose uptake at PET were predictive of major adverse cardiac events in cardiac sarcoidosis. Limitations include few studies with direct comparison and risk of bias. Systematic review registration no. CRD42021214776 (PROSPERO) © RSNA, 2023 Supplemental material is available for this article. + + + + Aitken + Matthew + M + 0000-0002-2475-8372 + + From the Department of Medical Imaging (M.A., C.U.F., P.T., K.H.) and Division of Cardiology (P.T., M.R.I., Y.M.), Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, University of Toronto, 585 University Ave, 1 PMB-298, Toronto, ON, Canada M5G 2N2; Faculty of Medicine, University of Toronto, Toronto, Canada (M.D.); Department of Radiology, Concord Hospital Clinical School, The University of Sydney, Sydney, Australia (M.V.C., Y.R.H.); Qscan Imaging Group, Clayfield, Australia (L.I.V.); Department of Radiology, Gold Coast University Hospital, Southport, Australia (B.J.M.); Cardiothoracic Imaging Unit, Hospital San Juan de Dios, HT Médica, Córdoba, Spain (J.B.); Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, Canada (P.T., K.H.); Department of Radiology and Epidemiology, University of Ottawa, Ottawa Hospital Research Institute Clinical Epidemiology Program, Ottawa, Canada (M.D.F.M.); Division of Molecular Imaging, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada (M.R.I.); Division of Respiratory Medicine, Sinai Health System, University of Toronto, Toronto, Canada (M.B.); and Department of Library and Information Services, University Health Network, University of Toronto, Toronto, Canada (A.F.). + + + + Davidson + Malcolm + M + 0000-0003-0953-2567 + + From the Department of Medical Imaging (M.A., C.U.F., P.T., K.H.) and Division of Cardiology (P.T., M.R.I., Y.M.), Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, University of Toronto, 585 University Ave, 1 PMB-298, Toronto, ON, Canada M5G 2N2; Faculty of Medicine, University of Toronto, Toronto, Canada (M.D.); Department of Radiology, Concord Hospital Clinical School, The University of Sydney, Sydney, Australia (M.V.C., Y.R.H.); Qscan Imaging Group, Clayfield, Australia (L.I.V.); Department of Radiology, Gold Coast University Hospital, Southport, Australia (B.J.M.); Cardiothoracic Imaging Unit, Hospital San Juan de Dios, HT Médica, Córdoba, Spain (J.B.); Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, Canada (P.T., K.H.); Department of Radiology and Epidemiology, University of Ottawa, Ottawa Hospital Research Institute Clinical Epidemiology Program, Ottawa, Canada (M.D.F.M.); Division of Molecular Imaging, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada (M.R.I.); Division of Respiratory Medicine, Sinai Health System, University of Toronto, Toronto, Canada (M.B.); and Department of Library and Information Services, University Health Network, University of Toronto, Toronto, Canada (A.F.). + + + + Chan + Michael V + MV + 0000-0002-6120-562X + + From the Department of Medical Imaging (M.A., C.U.F., P.T., K.H.) and Division of Cardiology (P.T., M.R.I., Y.M.), Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, University of Toronto, 585 University Ave, 1 PMB-298, Toronto, ON, Canada M5G 2N2; Faculty of Medicine, University of Toronto, Toronto, Canada (M.D.); Department of Radiology, Concord Hospital Clinical School, The University of Sydney, Sydney, Australia (M.V.C., Y.R.H.); Qscan Imaging Group, Clayfield, Australia (L.I.V.); Department of Radiology, Gold Coast University Hospital, Southport, Australia (B.J.M.); Cardiothoracic Imaging Unit, Hospital San Juan de Dios, HT Médica, Córdoba, Spain (J.B.); Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, Canada (P.T., K.H.); Department of Radiology and Epidemiology, University of Ottawa, Ottawa Hospital Research Institute Clinical Epidemiology Program, Ottawa, Canada (M.D.F.M.); Division of Molecular Imaging, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada (M.R.I.); Division of Respiratory Medicine, Sinai Health System, University of Toronto, Toronto, Canada (M.B.); and Department of Library and Information Services, University Health Network, University of Toronto, Toronto, Canada (A.F.). + + + + Urzua Fresno + Camila + C + + From the Department of Medical Imaging (M.A., C.U.F., P.T., K.H.) and Division of Cardiology (P.T., M.R.I., Y.M.), Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, University of Toronto, 585 University Ave, 1 PMB-298, Toronto, ON, Canada M5G 2N2; Faculty of Medicine, University of Toronto, Toronto, Canada (M.D.); Department of Radiology, Concord Hospital Clinical School, The University of Sydney, Sydney, Australia (M.V.C., Y.R.H.); Qscan Imaging Group, Clayfield, Australia (L.I.V.); Department of Radiology, Gold Coast University Hospital, Southport, Australia (B.J.M.); Cardiothoracic Imaging Unit, Hospital San Juan de Dios, HT Médica, Córdoba, Spain (J.B.); Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, Canada (P.T., K.H.); Department of Radiology and Epidemiology, University of Ottawa, Ottawa Hospital Research Institute Clinical Epidemiology Program, Ottawa, Canada (M.D.F.M.); Division of Molecular Imaging, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada (M.R.I.); Division of Respiratory Medicine, Sinai Health System, University of Toronto, Toronto, Canada (M.B.); and Department of Library and Information Services, University Health Network, University of Toronto, Toronto, Canada (A.F.). + + + + Vasquez + Leon I + LI + 0000-0002-2159-8537 + + From the Department of Medical Imaging (M.A., C.U.F., P.T., K.H.) and Division of Cardiology (P.T., M.R.I., Y.M.), Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, University of Toronto, 585 University Ave, 1 PMB-298, Toronto, ON, Canada M5G 2N2; Faculty of Medicine, University of Toronto, Toronto, Canada (M.D.); Department of Radiology, Concord Hospital Clinical School, The University of Sydney, Sydney, Australia (M.V.C., Y.R.H.); Qscan Imaging Group, Clayfield, Australia (L.I.V.); Department of Radiology, Gold Coast University Hospital, Southport, Australia (B.J.M.); Cardiothoracic Imaging Unit, Hospital San Juan de Dios, HT Médica, Córdoba, Spain (J.B.); Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, Canada (P.T., K.H.); Department of Radiology and Epidemiology, University of Ottawa, Ottawa Hospital Research Institute Clinical Epidemiology Program, Ottawa, Canada (M.D.F.M.); Division of Molecular Imaging, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada (M.R.I.); Division of Respiratory Medicine, Sinai Health System, University of Toronto, Toronto, Canada (M.B.); and Department of Library and Information Services, University Health Network, University of Toronto, Toronto, Canada (A.F.). + + + + Huo + Ya R + YR + 0000-0001-6282-7677 + + From the Department of Medical Imaging (M.A., C.U.F., P.T., K.H.) and Division of Cardiology (P.T., M.R.I., Y.M.), Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, University of Toronto, 585 University Ave, 1 PMB-298, Toronto, ON, Canada M5G 2N2; Faculty of Medicine, University of Toronto, Toronto, Canada (M.D.); Department of Radiology, Concord Hospital Clinical School, The University of Sydney, Sydney, Australia (M.V.C., Y.R.H.); Qscan Imaging Group, Clayfield, Australia (L.I.V.); Department of Radiology, Gold Coast University Hospital, Southport, Australia (B.J.M.); Cardiothoracic Imaging Unit, Hospital San Juan de Dios, HT Médica, Córdoba, Spain (J.B.); Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, Canada (P.T., K.H.); Department of Radiology and Epidemiology, University of Ottawa, Ottawa Hospital Research Institute Clinical Epidemiology Program, Ottawa, Canada (M.D.F.M.); Division of Molecular Imaging, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada (M.R.I.); Division of Respiratory Medicine, Sinai Health System, University of Toronto, Toronto, Canada (M.B.); and Department of Library and Information Services, University Health Network, University of Toronto, Toronto, Canada (A.F.). + + + + McAllister + Brylie J + BJ + 0000-0002-2468-3016 + + From the Department of Medical Imaging (M.A., C.U.F., P.T., K.H.) and Division of Cardiology (P.T., M.R.I., Y.M.), Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, University of Toronto, 585 University Ave, 1 PMB-298, Toronto, ON, Canada M5G 2N2; Faculty of Medicine, University of Toronto, Toronto, Canada (M.D.); Department of Radiology, Concord Hospital Clinical School, The University of Sydney, Sydney, Australia (M.V.C., Y.R.H.); Qscan Imaging Group, Clayfield, Australia (L.I.V.); Department of Radiology, Gold Coast University Hospital, Southport, Australia (B.J.M.); Cardiothoracic Imaging Unit, Hospital San Juan de Dios, HT Médica, Córdoba, Spain (J.B.); Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, Canada (P.T., K.H.); Department of Radiology and Epidemiology, University of Ottawa, Ottawa Hospital Research Institute Clinical Epidemiology Program, Ottawa, Canada (M.D.F.M.); Division of Molecular Imaging, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada (M.R.I.); Division of Respiratory Medicine, Sinai Health System, University of Toronto, Toronto, Canada (M.B.); and Department of Library and Information Services, University Health Network, University of Toronto, Toronto, Canada (A.F.). + + + + Broncano + Jordi + J + 0000-0002-0683-8061 + + From the Department of Medical Imaging (M.A., C.U.F., P.T., K.H.) and Division of Cardiology (P.T., M.R.I., Y.M.), Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, University of Toronto, 585 University Ave, 1 PMB-298, Toronto, ON, Canada M5G 2N2; Faculty of Medicine, University of Toronto, Toronto, Canada (M.D.); Department of Radiology, Concord Hospital Clinical School, The University of Sydney, Sydney, Australia (M.V.C., Y.R.H.); Qscan Imaging Group, Clayfield, Australia (L.I.V.); Department of Radiology, Gold Coast University Hospital, Southport, Australia (B.J.M.); Cardiothoracic Imaging Unit, Hospital San Juan de Dios, HT Médica, Córdoba, Spain (J.B.); Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, Canada (P.T., K.H.); Department of Radiology and Epidemiology, University of Ottawa, Ottawa Hospital Research Institute Clinical Epidemiology Program, Ottawa, Canada (M.D.F.M.); Division of Molecular Imaging, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada (M.R.I.); Division of Respiratory Medicine, Sinai Health System, University of Toronto, Toronto, Canada (M.B.); and Department of Library and Information Services, University Health Network, University of Toronto, Toronto, Canada (A.F.). + + + + Thavendiranathan + Paaladinesh + P + 0000-0002-6497-1098 + + From the Department of Medical Imaging (M.A., C.U.F., P.T., K.H.) and Division of Cardiology (P.T., M.R.I., Y.M.), Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, University of Toronto, 585 University Ave, 1 PMB-298, Toronto, ON, Canada M5G 2N2; Faculty of Medicine, University of Toronto, Toronto, Canada (M.D.); Department of Radiology, Concord Hospital Clinical School, The University of Sydney, Sydney, Australia (M.V.C., Y.R.H.); Qscan Imaging Group, Clayfield, Australia (L.I.V.); Department of Radiology, Gold Coast University Hospital, Southport, Australia (B.J.M.); Cardiothoracic Imaging Unit, Hospital San Juan de Dios, HT Médica, Córdoba, Spain (J.B.); Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, Canada (P.T., K.H.); Department of Radiology and Epidemiology, University of Ottawa, Ottawa Hospital Research Institute Clinical Epidemiology Program, Ottawa, Canada (M.D.F.M.); Division of Molecular Imaging, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada (M.R.I.); Division of Respiratory Medicine, Sinai Health System, University of Toronto, Toronto, Canada (M.B.); and Department of Library and Information Services, University Health Network, University of Toronto, Toronto, Canada (A.F.). + + + + McInnes + Matthew D F + MDF + 0000-0001-8404-4075 + + From the Department of Medical Imaging (M.A., C.U.F., P.T., K.H.) and Division of Cardiology (P.T., M.R.I., Y.M.), Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, University of Toronto, 585 University Ave, 1 PMB-298, Toronto, ON, Canada M5G 2N2; Faculty of Medicine, University of Toronto, Toronto, Canada (M.D.); Department of Radiology, Concord Hospital Clinical School, The University of Sydney, Sydney, Australia (M.V.C., Y.R.H.); Qscan Imaging Group, Clayfield, Australia (L.I.V.); Department of Radiology, Gold Coast University Hospital, Southport, Australia (B.J.M.); Cardiothoracic Imaging Unit, Hospital San Juan de Dios, HT Médica, Córdoba, Spain (J.B.); Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, Canada (P.T., K.H.); Department of Radiology and Epidemiology, University of Ottawa, Ottawa Hospital Research Institute Clinical Epidemiology Program, Ottawa, Canada (M.D.F.M.); Division of Molecular Imaging, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada (M.R.I.); Division of Respiratory Medicine, Sinai Health System, University of Toronto, Toronto, Canada (M.B.); and Department of Library and Information Services, University Health Network, University of Toronto, Toronto, Canada (A.F.). + + + + Iwanochko + Mark R + MR + 0000-0001-7455-4469 + + From the Department of Medical Imaging (M.A., C.U.F., P.T., K.H.) and Division of Cardiology (P.T., M.R.I., Y.M.), Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, University of Toronto, 585 University Ave, 1 PMB-298, Toronto, ON, Canada M5G 2N2; Faculty of Medicine, University of Toronto, Toronto, Canada (M.D.); Department of Radiology, Concord Hospital Clinical School, The University of Sydney, Sydney, Australia (M.V.C., Y.R.H.); Qscan Imaging Group, Clayfield, Australia (L.I.V.); Department of Radiology, Gold Coast University Hospital, Southport, Australia (B.J.M.); Cardiothoracic Imaging Unit, Hospital San Juan de Dios, HT Médica, Córdoba, Spain (J.B.); Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, Canada (P.T., K.H.); Department of Radiology and Epidemiology, University of Ottawa, Ottawa Hospital Research Institute Clinical Epidemiology Program, Ottawa, Canada (M.D.F.M.); Division of Molecular Imaging, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada (M.R.I.); Division of Respiratory Medicine, Sinai Health System, University of Toronto, Toronto, Canada (M.B.); and Department of Library and Information Services, University Health Network, University of Toronto, Toronto, Canada (A.F.). + + + + Balter + Meyer + M + 0000-0002-0259-5138 + + From the Department of Medical Imaging (M.A., C.U.F., P.T., K.H.) and Division of Cardiology (P.T., M.R.I., Y.M.), Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, University of Toronto, 585 University Ave, 1 PMB-298, Toronto, ON, Canada M5G 2N2; Faculty of Medicine, University of Toronto, Toronto, Canada (M.D.); Department of Radiology, Concord Hospital Clinical School, The University of Sydney, Sydney, Australia (M.V.C., Y.R.H.); Qscan Imaging Group, Clayfield, Australia (L.I.V.); Department of Radiology, Gold Coast University Hospital, Southport, Australia (B.J.M.); Cardiothoracic Imaging Unit, Hospital San Juan de Dios, HT Médica, Córdoba, Spain (J.B.); Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, Canada (P.T., K.H.); Department of Radiology and Epidemiology, University of Ottawa, Ottawa Hospital Research Institute Clinical Epidemiology Program, Ottawa, Canada (M.D.F.M.); Division of Molecular Imaging, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada (M.R.I.); Division of Respiratory Medicine, Sinai Health System, University of Toronto, Toronto, Canada (M.B.); and Department of Library and Information Services, University Health Network, University of Toronto, Toronto, Canada (A.F.). + + + + Moayedi + Yasbanoo + Y + 0000-0002-3288-7393 + + From the Department of Medical Imaging (M.A., C.U.F., P.T., K.H.) and Division of Cardiology (P.T., M.R.I., Y.M.), Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, University of Toronto, 585 University Ave, 1 PMB-298, Toronto, ON, Canada M5G 2N2; Faculty of Medicine, University of Toronto, Toronto, Canada (M.D.); Department of Radiology, Concord Hospital Clinical School, The University of Sydney, Sydney, Australia (M.V.C., Y.R.H.); Qscan Imaging Group, Clayfield, Australia (L.I.V.); Department of Radiology, Gold Coast University Hospital, Southport, Australia (B.J.M.); Cardiothoracic Imaging Unit, Hospital San Juan de Dios, HT Médica, Córdoba, Spain (J.B.); Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, Canada (P.T., K.H.); Department of Radiology and Epidemiology, University of Ottawa, Ottawa Hospital Research Institute Clinical Epidemiology Program, Ottawa, Canada (M.D.F.M.); Division of Molecular Imaging, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada (M.R.I.); Division of Respiratory Medicine, Sinai Health System, University of Toronto, Toronto, Canada (M.B.); and Department of Library and Information Services, University Health Network, University of Toronto, Toronto, Canada (A.F.). + + + + Farrell + Ashley + A + 0000-0002-4044-8585 + + From the Department of Medical Imaging (M.A., C.U.F., P.T., K.H.) and Division of Cardiology (P.T., M.R.I., Y.M.), Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, University of Toronto, 585 University Ave, 1 PMB-298, Toronto, ON, Canada M5G 2N2; Faculty of Medicine, University of Toronto, Toronto, Canada (M.D.); Department of Radiology, Concord Hospital Clinical School, The University of Sydney, Sydney, Australia (M.V.C., Y.R.H.); Qscan Imaging Group, Clayfield, Australia (L.I.V.); Department of Radiology, Gold Coast University Hospital, Southport, Australia (B.J.M.); Cardiothoracic Imaging Unit, Hospital San Juan de Dios, HT Médica, Córdoba, Spain (J.B.); Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, Canada (P.T., K.H.); Department of Radiology and Epidemiology, University of Ottawa, Ottawa Hospital Research Institute Clinical Epidemiology Program, Ottawa, Canada (M.D.F.M.); Division of Molecular Imaging, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada (M.R.I.); Division of Respiratory Medicine, Sinai Health System, University of Toronto, Toronto, Canada (M.B.); and Department of Library and Information Services, University Health Network, University of Toronto, Toronto, Canada (A.F.). + + + + Hanneman + Kate + K + 0000-0002-3077-2218 + + From the Department of Medical Imaging (M.A., C.U.F., P.T., K.H.) and Division of Cardiology (P.T., M.R.I., Y.M.), Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, University of Toronto, 585 University Ave, 1 PMB-298, Toronto, ON, Canada M5G 2N2; Faculty of Medicine, University of Toronto, Toronto, Canada (M.D.); Department of Radiology, Concord Hospital Clinical School, The University of Sydney, Sydney, Australia (M.V.C., Y.R.H.); Qscan Imaging Group, Clayfield, Australia (L.I.V.); Department of Radiology, Gold Coast University Hospital, Southport, Australia (B.J.M.); Cardiothoracic Imaging Unit, Hospital San Juan de Dios, HT Médica, Córdoba, Spain (J.B.); Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, Canada (P.T., K.H.); Department of Radiology and Epidemiology, University of Ottawa, Ottawa Hospital Research Institute Clinical Epidemiology Program, Ottawa, Canada (M.D.F.M.); Division of Molecular Imaging, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada (M.R.I.); Division of Respiratory Medicine, Sinai Health System, University of Toronto, Toronto, Canada (M.B.); and Department of Library and Information Services, University Health Network, University of Toronto, Toronto, Canada (A.F.). + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Radiology + 0401260 + 0033-8419 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 36 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809215 + 10.1148/radiol.222483 + + +
+ + + 36809193 + + 2023 + 02 + 22 + +
+ + 1530-0374 + + + 2023 + Feb + 21 + + + Menopause (New York, N.Y.) + Menopause + + A multicenter, randomized, placebo-controlled study to select the minimum effective dose of estetrol in postmenopausal participants (E4Relief): part 2-vaginal cytology, genitourinary syndrome of menopause, and health-related quality of life. + 10.1097/GME.0000000000002167 + + A phase 2 study showed that 15 mg estetrol (E4) alleviates vasomotor symptoms (VMS). Here, we present the effects of E4 15 mg on vaginal cytology, genitourinary syndrome of menopause, and health-related quality of life. + In a double-blind, placebo-controlled study, postmenopausal participants (n = 257, 40-65 y) were randomized to receive E4 2.5, 5, 10, or 15 mg or placebo once daily for 12 weeks. Outcomes were the vaginal maturation index and maturation value, genitourinary syndrome of menopause score, and the Menopause Rating Scale to assess health-related quality of life. We focused on E4 15 mg, the dose studied in ongoing phase 3 trials, and tested its effect versus placebo at 12 weeks using analysis of covariance. + Least square (LS) mean percentages of parabasal and intermediate cells decreased, whereas superficial cells increased across E4 doses; for E4 15 mg, the respective changes were -10.81% (P = 0.0017), -20.96% (P = 0.0037), and +34.17% (P < 0.0001). E4 15 mg decreased LS mean intensity score for vaginal dryness and dyspareunia (-0.40, P = 0.03, and -0.47, P = 0.0006, respectively); symptom reporting decreased by 41% and 50%, respectively, and shifted to milder intensity categories. The overall Menopause Rating Scale score decreased with E4 15 mg (LS mean, -3.1; P = 0.069) and across doses was associated with a decreasing frequency and severity of VMS (r = 0.34 and r = 0.31, P < 0.001). + E4 demonstrated estrogenic effects in the vagina and decreased signs of atrophy. E4 15 mg is a promising treatment option also for important menopausal symptoms other than VMS. + Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The North American Menopause Society. + + + + Gaspard + Ulysse + U + + From the Department of Obstetrics and Gynecology, University of Liège, Liège, Belgium. + + + + Taziaux + Mélanie + M + + Estetra SRL, Mithra Pharmaceuticals, Liège, Belgium. + + + + Jost + Maud + M + + Estetra SRL, Mithra Pharmaceuticals, Liège, Belgium. + + + + Coelingh Bennink + Herjan J T + HJT + + Pantarhei Bioscience, Zeist, the Netherlands. + + + + Utian + Wulf H + WH + + Case Western Reserve University School of Medicine, Cleveland, OH. + + + + Lobo + Rogerio A + RA + + Columbia University Medical Center, New York, NY. + + + + Foidart + Jean-Michel + JM + + + eng + + + ClinicalTrials.gov + + NCT04209543 + NCT02834312 + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Menopause + 9433353 + 1072-3714 + + IM + Financial disclosure/conflicts of interest: M.T. and M.J. are employees, U.G. and J.-M.F. are consultants, and W.H.U. and R.A.L. are members of the Scientific Advisory Board of Mithra Pharmaceuticals. W.H.U. received funding from Pharmavite, Los Angeles. H.J.T.C.B. is president and CEO of Pantarhei Bioscience. +
+ + + + 2023 + 2 + 22 + 13 + 35 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809193 + 10.1097/GME.0000000000002167 + 00042192-990000000-00160 + + + + Monteleone P, Mascagni G, Giannini A, Genazzani AR, Simoncini T. Symptoms of menopause — global prevalence, physiology and implications. Nat Rev Endocrinol 2018;14:199–215. doi: 10.1038/nrendo.2017.180 + + 10.1038/nrendo.2017.180 + + + + Mac Bride MB, Rhodes DJ, Shuster LT. Vulvovaginal atrophy. Mayo Clin Proc 2010;85:87–94. doi: 10.4065/mcp.2009.0413 + + 10.4065/mcp.2009.0413 + + + + Robinson D, Cardozo LD. The role of estrogens in female lower urinary tract dysfunction. Urology 2003;62(4 Suppl 1):45–51. doi: 10.1016/s0090-4295(03)00676-9 + + 10.1016/s0090-4295(03)00676-9 + + + + Portman DJ, Gass ML; Vulvovaginal Atrophy Terminology Consensus Conference Panel. 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Menopause 2018;25:1418–1423. doi: 10.1097/GME.0000000000001148 + + 10.1097/GME.0000000000001148 + + + + Thurston RC, Sutton-Tyrrell K, Everson-Rose SA, Hess R, Powell LH, Matthews KA. Hot flashes and carotid intima media thickness among midlife women. Menopause 2011;18:352–358. doi: 10.1097/gme.0b013e3181fa27fd + + 10.1097/gme.0b013e3181fa27fd + + + + Maki PM, Thurston RC. Menopause and brain health: hormonal changes are only part of the story. Front Neurol 2020;11:562275. doi: 10.3389/fneur.2020.562275 + + 10.3389/fneur.2020.562275 + + + + Utian WH, Woods NF. Impact of hormone therapy on quality of life after menopause. Menopause 2013;20:1098–1105. doi: 10.1097/GME.0b013e318298debe + + 10.1097/GME.0b013e318298debe + + + + The NAMS 2020 GSM Position Statement Editorial Panel. The 2020 genitourinary syndrome of menopause position statement of The North American Menopause Society. 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Estetrol (E4) is a unique native estrogen that does not modify coagulation markers in postmenopausal women and maintains sensitivity to activated protein C (APC). Menopause 2019;26:1464–1465. + + + Arnal JF, Lenfant F, Metivier R, et al. Membrane and nuclear estrogen receptor alpha actions: from tissue specificity to medical implications. Physiol Rev 2017;97:1045–1087. doi: 10.1152/physrev.00024.2016 + + 10.1152/physrev.00024.2016 + + + + Gerard C, Arnal JF, Jost M, et al. Profile of estetrol, a promising native estrogen for oral contraception and the relief of climacteric symptoms of menopause. Expert Rev Clin Pharmacol 2022;15:121–137. doi: 10.1080/17512433.2022.2054413 + + 10.1080/17512433.2022.2054413 + + + + Douxfils J, Morimont L, Gaspard U, Utian WH, Foidart JM. Estetrol is not a SERM but a NEST and has a specific safety profile on coagulation [published online September 16, 2022]. 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+ + + 36809199 + + 2023 + 02 + 22 + +
+ + 1537-1611 + + 24 + 3 + + 2023 + Mar + 01 + + + Journal of clinical neuromuscular disease + J Clin Neuromuscul Dis + + Landscape of Guillain-Barré Syndrome Interventional Clinical Trials. + + 119-129 + + 10.1097/CND.0000000000000441 + + Guillain-Barré syndrome (GBS) is an immune-mediated polyradiculoneuropathy that remains a debilitating disease despite medical treatment. Numerous challenges still exist, including the development of disease-modifying therapies that can improve prognosis, particularly in patients with poor prognostic outcomes. In this study, we explored clinical trials related to GBS, analyzed the trial characteristics, suggested some ideas for improvement, and discussed recent advances. + On December 30, 2021, the authors searched ClinicalTrials.gov for all interventional and therapeutic clinical trials related to GBS, without any restrictions on the date or location. Trial characteristics including trial duration, location, phase, sample size, and publications were retrieved and analyzed. + Twenty-one trials fulfilled the selection criteria. Clinical trials were conducted in 11 different countries, most of them occurring in Asia. On average, the trial duration across the phases was around 2 years. About two-thirds of trials were completed, and 39% of trials were in the early phases (1 and 2). Only 24% of all trials and 60% of completed trials have publications in this study. + The study revealed a low number of trials, lack of geographic diversity, scanty enrollment of patients, and paucity of clinical trial duration and publications regarding GBS clinical trials. Optimization of GBS trials is fundamental to achieving effective therapies for this disease. + Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved. + + + + Saleh + Mustafa + M + + Faculty of Medical Sciences, Lebanese University, Lebanon. + + + + Boukhdoud + Mona + M + + Faculty of Medical Sciences, Lebanese University, Lebanon. + + + + Boukhdoud + Hayam + H + + Faculty of Medical Sciences, Lebanese University, Lebanon. + + + + Al Zein + Mohammad + M + + Faculty of Medical Sciences, Lebanese University, Lebanon. + + + + Salameh + Pascale + P + + Faculty of Medical Sciences, Lebanese University, Lebanon. + + + School of Medicine, Lebanese American University, Byblos, Lebanon. + + + Institut National de Santé Publique, Epidémiologie Clinique et Toxicologie (INSPECT-LB), Beirut, Lebanon; and. + + + University of Nicosia Medical School, Nicosia, Cyprus. + + + + eng + + + ClinicalTrials.gov + + NCTID-an id + NCTID to re + NCT00411216 + NCT01306578 + + + + + Journal Article + +
+ + United States + J Clin Neuromuscul Dis + 100887391 + 1522-0443 + + IM + The authors report no conflicts of interest. +
+ + + + 2023 + 2 + 22 + 13 + 36 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809199 + 10.1097/CND.0000000000000441 + 00131402-202303000-00001 + + + + Criteria for diagnosis of Guillain-Barré syndrome. Ann Neurol. 1978;3:565–566. + + + Asbury AK, Cornblath DR. Assessment of current diagnostic criteria for Guillain-Barré syndrome. Ann Neurol. 1990;27(suppl l):S21–S24. + + + Pithadia AB, Kakadia N. Guillain-Barré syndrome (GBS). Pharmacol Rep. 2010;62:220–232. + + + Sejvar JJ, Baughman AL, Wise M, et al. Population incidence of Guillain-Barré syndrome: a systematic review and meta-analysis. Neuroepidemiology. 2011;36:123–133. + + + Donofrio PD. Guillain-Barré syndrome. Continuum (Minneap Minn). 2017;23:1295–1309. + + + Shahrizaila N, Lehmann HC, Kuwabara S. Guillain-Barré syndrome. Lancet. 2021;397:1214–1228. + + + Avila-Funes JA, Mariona-Montero VA, Melano-Carranza E. Guillain-Barre syndrome: etiology and pathogenesis. 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+ + + 36809201 + + 2023 + 02 + 22 + +
+ + 1537-1611 + + 24 + 3 + + 2023 + Mar + 01 + + + Journal of clinical neuromuscular disease + J Clin Neuromuscul Dis + + Neuropathy, Ataxia, and Retinitis Pigmentosa Syndrome. + + 140-146 + + 10.1097/CND.0000000000000422 + + To provide an overview about the phenotype, genotype, treatment, and outcome of neuropathy, ataxia, and retinitis pigmentosa (NARP) syndrome. + Systematic review by application of appropriate search terms. + NARP syndrome is a syndromic mitochondrial disorder due to pathogenic variants in MT-ATP6. The canonical phenotypic features of NARP syndrome include proximal muscle weakness, axonal neuropathy, cerebellar ataxia, and retinitis pigmentosa. Noncanonical phenotypic features in NARP include epilepsy, cerebral or cerebellar atrophy, optic atrophy, cognitive impairment, dementia, sleep apnea syndrome, hearing impairment, renal insufficiency, and diabetes. So far, 10 pathogenic variants in MT-ATP6 have been associated with NARP, NARP-like syndrome, or NARP/maternally inherited Leigh overlap syndrome. Most pathogenic MT-ATP6 variants are missense, but a few truncating pathogenic variants have been reported. The most common variant responsible for NARP is the transversion m.8993T>G. Only symptomatic treatment for NARP syndrome is available. In most of the cases, patients die prematurely. Patients with late-onset NARP survive longer. + NARP is a rare, syndromic, monogenic mitochondrial disorder due to pathogenic variants in MT-ATP6. The nervous system and the eyes are most commonly affected. Although only symptomatic treatment is available, the outcome is usually fair. + Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved. + + + + Finsterer + Josef + J + + Neurology & Neurophysiology Center, Vienna, Austria. + + + + eng + + Journal Article + +
+ + United States + J Clin Neuromuscul Dis + 100887391 + 1522-0443 + + IM + The author reports no conflicts of interest. +
+ + + + 2023 + 2 + 22 + 13 + 36 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809201 + 10.1097/CND.0000000000000422 + 00131402-202303000-00003 + + + + Stendel C, Neuhofer C, Floride E, et al.; ATP6 Study Group. Delineating MT-ATP6-associated disease: from isolated neuropathy to early onset neurodegeneration. Neurol Genet. 2020;6:e393. + + + Kytövuori L, Lipponen J, Rusanen H, et al. A novel mutation m.8561C>G in MT-ATP6/8 causing a mitochondrial syndrome with ataxia, peripheral neuropathy, diabetes mellitus, and hypergonadotropic hypogonadism. J Neurol. 2016;263:2188–2195. + + + Fragaki K, Chaussenot A, Serre V, et al. A novel variant m.8561C>T in the overlapping region of MT-ATP6 and MT-ATP8 in a child with early-onset severe neurological signs. Mol Genet Metab Rep. 2019;21:100543. + + + Thorburn DR, Rahman J, Rahman S. Mitochondrial DNA-associated Leigh syndrome and NARP. In: Adam MP, Ardinger HH, Pagon RA, et al, eds. GeneReviews® [Internet]. 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The pathogenic MT-ATP6 m.8851T>C mutation prevents proton movements within the n-side hydrophilic cleft of the membrane domain of ATP synthase. Biochim Biophys Acta Bioenerg. 2019;1860:562–572. + + + Gencer Öncül EB, Duman D, Eminoğlu FT, et al. Whole mitochondrial genome analysis in Turkish patients with mitochondrial diseases. Balkan Med J. 2021;39:96–106. + + + Kenvin S, Torregrosa-Muñumer R, Reidelbach M, et al. Threshold of heteroplasmic truncating MT-ATP6 mutation in reprogramming, Notch hyperactivation and motor neuron metabolism. Hum Mol Genet. 2021;31:958–974. + + + Bugiardini E, Bottani E, Marchet S, et al. Expanding the molecular and phenotypic spectrum of truncating MT-ATP6 mutations. Neurol Genet. 2020;6:e381. + + + Jackson CB, Hahn D, Schröter B, et al. A novel mitochondrial ATP6 frameshift mutation causing isolated complex V deficiency, ataxia and encephalomyopathy. Eur J Med Genet. 2017;60:345–351. + + + López-Gallardo E, Solano A, Herrero-Martín MD, et al. NARP syndrome in a patient harbouring an insertion in the MT-ATP6 gene that results in a truncated protein. J Med Genet. 2009;46:64–67. + + + Mordel P, Schaeffer S, Dupas Q, et al. A 2 bp deletion in the mitochondrial ATP 6 gene responsible for the NARP (neuropathy, ataxia, and retinitis pigmentosa) syndrome. Biochem Biophys Res Commun. 2017;494:133–137. + + + Enns GM, Bai RK, Beck AE, et al. Molecular-clinical correlations in a family with variable tissue mitochondrial DNA T8993G mutant load. Mol Genet Metab. 2006;88:364–371. + + + de Coo IF, Smeets HJ, Gabreëls FJ, et al. Isolated case of mental retardation and ataxia due to a de novo mitochondrial T8993G mutation. Am J Hum Genet. 1996;58:636–638. + + + Claeys KG, Abicht A, Häusler M, et al. Novel genetic and neuropathological insights in neurogenic muscle weakness, ataxia, and retinitis pigmentosa (NARP). Muscle Nerve. 2016;54:328–333. + + + Mattiazzi M, Vijayvergiya C, Gajewski CD, et al. The mtDNA T8993G (NARP) mutation results in an impairment of oxidative phosphorylation that can be improved by antioxidants. Hum Mol Genet. 2004;13:869–879. + + + Playán A, Solano-Palacios A, González de la Rosa JB, et al. Síndrome de Leigh producido por una mutación de novo T8993G en el ADN mitocondrial Leigh syndrome resulting from a de novo mitochondrial DNA mutation (T8993G). Rev Neurol. 2002;34:1124–1126. + + + Kara B, Arıkan M, Maraş H, et al. Whole mitochondrial genome analysis of a family with NARP/MILS caused by m.8993T>C mutation in the MT-ATP6 gene. Mol Genet Metab. 2012;107:389–393. + + + Jonckheere AI, Smeitink JA, Rodenburg RJ. Mitochondrial ATP synthase: architecture, function and pathology. J Inherit Metab Dis. 2012;35:211–225. + + + Craig K, Elliott HR, Keers SM, et al. Episodic ataxia and hemiplegia caused by the 8993T->C mitochondrial DNA mutation. J Med Genet. 2007;44:797–799. + + + Pfeffer G, Blakely EL, Alston CL, et al. Adult-onset spinocerebellar ataxia syndromes due to MTATP6 mutations. J Neurol Neurosurg Psychiatry. 2012;83:883–886. + + + Su TH, Lee NC, Wu CS, et al. Episodic weakness and axonal sensorimotor neuropathy caused by a mitochondrial MT-ATP6 mutation. J Formos Med Assoc. 2021;81:1810–1818. + + + Auré K, Dubourg O, Jardel C, et al. Episodic weakness due to mitochondrial DNA MT-ATP6/8 mutations. Neurology. 2013;81:1810–1818. + + + Hung PC, Wang HS. A previously undescribed leukodystrophy in Leigh syndrome associated with T9176C mutation of the mitochondrial ATPase 6 gene. Dev Med Child Neurol. 2007;49:65–67. + + + Ronchi D, Bordoni A, Cosi A, et al. Unusual adult-onset Leigh syndrome presentation due to the mitochondrial m.9176T>C mutation. Biochem Biophys Res Commun. 2011;412:245–248. + + + Kabala AM, Lasserre JP, Ackerman SH, et al. Defining the impact on yeast ATP synthase of two pathogenic human mitochondrial DNA mutations, T9185C and T9191C. 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Selective elimination of mutant mitochondrial genomes as therapeutic strategy for the treatment of NARP and MILS syndromes. Gene Ther. 2008;15:516–523. + + + Hsiao CW, Peng TI, Peng AC, et al. Long-term Aβ exposure augments mCa2+-independent mROS-mediated depletion of cardiolipin for the shift of a lethal transient mitochondrial permeability transition to its permanent mode in NARP cybrids: a protective targeting of melatonin. J Pineal Res. 2013;54:107–125. + + + Peng TI, Hsiao CW, Reiter RJ, et al. mtDNA T8993G mutation-induced mitochondrial complex V inhibition augments cardiolipin-dependent alterations in mitochondrial dynamics during oxidative, Ca(2+), and lipid insults in NARP cybrids: a potential therapeutic target for melatonin. J Pineal Res. 2012;52:93–106. + + + Dassa EP, Paupe V, Gonçalves S, et al. The mtDNA NARP mutation activates the actin-Nrf2 signaling of antioxidant defenses. Biochem Biophys Res Commun. 2008;368:620–624. + + + Gammage PA, Gaude E, Van Haute L, et al. Near-complete elimination of mutant mtDNA by iterative or dynamic dose-controlled treatment with mtZFNs. Nucleic Acids Res. 2016;44:7804–7816. + + + Sgarbi G, Casalena GA, Baracca A, et al. Human NARP mitochondrial mutation metabolism corrected with alpha-ketoglutarate/aspartate: a potential new therapy. Arch Neurol. 2009;66:951–957. + + + Poulton J, Finsterer J, Yu-Wai-Man P. Genetic counselling for maternally inherited mitochondrial disorders. Mol Diagn Ther. 2017;21:419–429. + + + Childs AM, Hutchin T, Pysden K, et al. Variable phenotype including Leigh syndrome with a 9185T>C mutation in the MTATP6 gene. Neuropediatrics. 2007;38:313–316. + + + Miyawaki T, Koto S, Ishihara H, et al. A case of neurologic muscle weakness, ataxia, and retinitis pigmentosa (NARP) syndrome with a novel mitochondrial mutation m.8729 G>A. Rinsho Shinkeigaku. 2015;55:91–95. + + + +
+ + + 36809217 + + 2023 + 02 + 22 + +
+ + 1527-1315 + + + 2023 + Feb + 21 + + + Radiology + Radiology + + Arteriovenous Graft Failure in the Veterans Health Administration: Outcome Disparities Associated with Race. + + 220619 + + 10.1148/radiol.220619 + + Background Vascular access for ongoing hemodialysis often fails, frequently requiring repeated procedures to maintain vascular patency. While research has shown racial discrepancies in multiple aspects of renal failure treatment, there is poor understanding of how these factors might relate to vascular access maintenance procedures after arteriovenous graft (AVG) placement. Purpose To evaluate racial disparities associated with premature vascular access failure after percutaneous access maintenance procedures following AVG placement using a retrospective national cohort from the Veterans Health Administration (VHA). Materials and Methods All hemodialysis vascular maintenance procedures performed at VHA hospitals between October 2016 and March 2020 were identified. To ensure the sample represented patients who consistently used the VHA, patients without AVG placement within 5 years of their first maintenance procedure were excluded. Access failure was defined as a repeat access maintenance procedure or as hemodialysis catheter placement occurring 1-30 days after the index procedure. Multivariable logistic regression analyses were performed to calculate prevalence ratios (PRs) measuring the association between hemodialysis maintenance failure and African American race compared with all other races. Models controlled for vascular access history, patient socioeconomic status, and procedure and facility characteristics. Results In total, 1950 access maintenance procedures in 995 patients (mean age, 69 years ± 9 [SD], 1870 men) with an AVG created in one of 61 VHA facilities were identified. Most procedures involved African American patients (1169 of 1950, 60%) and patients residing in the South (1002 of 1950, 51%). Premature access failure occurred in 215 of 1950 (11%) procedures. When compared with all other races, African American race was associated with premature access site failure (PR, 1.4; 95% CI: 1.07, 1.43; P = .02). Among the 1057 procedures in 30 facilities with interventional radiology resident training programs, there was no evidence of racial disparity in the outcome (PR, 1.1; P = .63). Conclusion African American race was associated with higher risk-adjusted rates of premature arteriovenous graft failure after dialysis maintenance. © RSNA, 2023 Supplemental material is available for this article. See also the editorial by Forman and Davis in this issue. + + + + Higgins + Mikhail C S S + MCSS + + From the Departments of Radiology (M.C.S.S.H.), Medical School (A.S., A.F.), Medicine (M.V.F.), and Surgery (H.J.M.), Boston University Chobanian & Avedisian School of Medicine, Boston, Mass; Department of Radiology, Boston Medical Center, Boston, Mass (M.C.S.S.H.); Center for Healthcare Organization and Implementation Research (M.F., D.J.S., K.H., R.P.L., W.B.E., H.J.M.), Department of Quality Management (M.V.F.), and Department of Medicine, Section of Infectious Diseases (W.B.E.), VA Boston Healthcare System, 150 S Huntington Ave, Boston, MA 02130; Office of Clinical Affairs, Commonwealth Medicine, University of Massachusetts Chan Medical School, Boston, Mass (N.B.); Department of Gastroenterology, Duke University School of Medicine, Durham, NC (B.A.S.); Cooperative Studies Program Epidemiology Center-Durham, Durham VA Health Care System, Durham, NC (B.A.S.); and Harvard Medical School, Boston, Mass (W.B.E.). + + + + Seren + Alex + A + 0000-0002-7438-6837 + + From the Departments of Radiology (M.C.S.S.H.), Medical School (A.S., A.F.), Medicine (M.V.F.), and Surgery (H.J.M.), Boston University Chobanian & Avedisian School of Medicine, Boston, Mass; Department of Radiology, Boston Medical Center, Boston, Mass (M.C.S.S.H.); Center for Healthcare Organization and Implementation Research (M.F., D.J.S., K.H., R.P.L., W.B.E., H.J.M.), Department of Quality Management (M.V.F.), and Department of Medicine, Section of Infectious Diseases (W.B.E.), VA Boston Healthcare System, 150 S Huntington Ave, Boston, MA 02130; Office of Clinical Affairs, Commonwealth Medicine, University of Massachusetts Chan Medical School, Boston, Mass (N.B.); Department of Gastroenterology, Duke University School of Medicine, Durham, NC (B.A.S.); Cooperative Studies Program Epidemiology Center-Durham, Durham VA Health Care System, Durham, NC (B.A.S.); and Harvard Medical School, Boston, Mass (W.B.E.). + + + + Foster + Marva V + MV + 0000-0002-2265-0413 + + From the Departments of Radiology (M.C.S.S.H.), Medical School (A.S., A.F.), Medicine (M.V.F.), and Surgery (H.J.M.), Boston University Chobanian & Avedisian School of Medicine, Boston, Mass; Department of Radiology, Boston Medical Center, Boston, Mass (M.C.S.S.H.); Center for Healthcare Organization and Implementation Research (M.F., D.J.S., K.H., R.P.L., W.B.E., H.J.M.), Department of Quality Management (M.V.F.), and Department of Medicine, Section of Infectious Diseases (W.B.E.), VA Boston Healthcare System, 150 S Huntington Ave, Boston, MA 02130; Office of Clinical Affairs, Commonwealth Medicine, University of Massachusetts Chan Medical School, Boston, Mass (N.B.); Department of Gastroenterology, Duke University School of Medicine, Durham, NC (B.A.S.); Cooperative Studies Program Epidemiology Center-Durham, Durham VA Health Care System, Durham, NC (B.A.S.); and Harvard Medical School, Boston, Mass (W.B.E.). + + + + Sturgeon + Daniel J + DJ + 0000-0002-9890-9161 + + From the Departments of Radiology (M.C.S.S.H.), Medical School (A.S., A.F.), Medicine (M.V.F.), and Surgery (H.J.M.), Boston University Chobanian & Avedisian School of Medicine, Boston, Mass; Department of Radiology, Boston Medical Center, Boston, Mass (M.C.S.S.H.); Center for Healthcare Organization and Implementation Research (M.F., D.J.S., K.H., R.P.L., W.B.E., H.J.M.), Department of Quality Management (M.V.F.), and Department of Medicine, Section of Infectious Diseases (W.B.E.), VA Boston Healthcare System, 150 S Huntington Ave, Boston, MA 02130; Office of Clinical Affairs, Commonwealth Medicine, University of Massachusetts Chan Medical School, Boston, Mass (N.B.); Department of Gastroenterology, Duke University School of Medicine, Durham, NC (B.A.S.); Cooperative Studies Program Epidemiology Center-Durham, Durham VA Health Care System, Durham, NC (B.A.S.); and Harvard Medical School, Boston, Mass (W.B.E.). + + + + Bart + Nina + N + 0000-0002-0969-0082 + + From the Departments of Radiology (M.C.S.S.H.), Medical School (A.S., A.F.), Medicine (M.V.F.), and Surgery (H.J.M.), Boston University Chobanian & Avedisian School of Medicine, Boston, Mass; Department of Radiology, Boston Medical Center, Boston, Mass (M.C.S.S.H.); Center for Healthcare Organization and Implementation Research (M.F., D.J.S., K.H., R.P.L., W.B.E., H.J.M.), Department of Quality Management (M.V.F.), and Department of Medicine, Section of Infectious Diseases (W.B.E.), VA Boston Healthcare System, 150 S Huntington Ave, Boston, MA 02130; Office of Clinical Affairs, Commonwealth Medicine, University of Massachusetts Chan Medical School, Boston, Mass (N.B.); Department of Gastroenterology, Duke University School of Medicine, Durham, NC (B.A.S.); Cooperative Studies Program Epidemiology Center-Durham, Durham VA Health Care System, Durham, NC (B.A.S.); and Harvard Medical School, Boston, Mass (W.B.E.). + + + + Hederstedt + Kierstin + K + + From the Departments of Radiology (M.C.S.S.H.), Medical School (A.S., A.F.), Medicine (M.V.F.), and Surgery (H.J.M.), Boston University Chobanian & Avedisian School of Medicine, Boston, Mass; Department of Radiology, Boston Medical Center, Boston, Mass (M.C.S.S.H.); Center for Healthcare Organization and Implementation Research (M.F., D.J.S., K.H., R.P.L., W.B.E., H.J.M.), Department of Quality Management (M.V.F.), and Department of Medicine, Section of Infectious Diseases (W.B.E.), VA Boston Healthcare System, 150 S Huntington Ave, Boston, MA 02130; Office of Clinical Affairs, Commonwealth Medicine, University of Massachusetts Chan Medical School, Boston, Mass (N.B.); Department of Gastroenterology, Duke University School of Medicine, Durham, NC (B.A.S.); Cooperative Studies Program Epidemiology Center-Durham, Durham VA Health Care System, Durham, NC (B.A.S.); and Harvard Medical School, Boston, Mass (W.B.E.). + + + + Friefeld + Alex + A + 0000-0002-6067-917X + + From the Departments of Radiology (M.C.S.S.H.), Medical School (A.S., A.F.), Medicine (M.V.F.), and Surgery (H.J.M.), Boston University Chobanian & Avedisian School of Medicine, Boston, Mass; Department of Radiology, Boston Medical Center, Boston, Mass (M.C.S.S.H.); Center for Healthcare Organization and Implementation Research (M.F., D.J.S., K.H., R.P.L., W.B.E., H.J.M.), Department of Quality Management (M.V.F.), and Department of Medicine, Section of Infectious Diseases (W.B.E.), VA Boston Healthcare System, 150 S Huntington Ave, Boston, MA 02130; Office of Clinical Affairs, Commonwealth Medicine, University of Massachusetts Chan Medical School, Boston, Mass (N.B.); Department of Gastroenterology, Duke University School of Medicine, Durham, NC (B.A.S.); Cooperative Studies Program Epidemiology Center-Durham, Durham VA Health Care System, Durham, NC (B.A.S.); and Harvard Medical School, Boston, Mass (W.B.E.). + + + + Lamkin + Rebecca P + RP + 0000-0002-5599-0924 + + From the Departments of Radiology (M.C.S.S.H.), Medical School (A.S., A.F.), Medicine (M.V.F.), and Surgery (H.J.M.), Boston University Chobanian & Avedisian School of Medicine, Boston, Mass; Department of Radiology, Boston Medical Center, Boston, Mass (M.C.S.S.H.); Center for Healthcare Organization and Implementation Research (M.F., D.J.S., K.H., R.P.L., W.B.E., H.J.M.), Department of Quality Management (M.V.F.), and Department of Medicine, Section of Infectious Diseases (W.B.E.), VA Boston Healthcare System, 150 S Huntington Ave, Boston, MA 02130; Office of Clinical Affairs, Commonwealth Medicine, University of Massachusetts Chan Medical School, Boston, Mass (N.B.); Department of Gastroenterology, Duke University School of Medicine, Durham, NC (B.A.S.); Cooperative Studies Program Epidemiology Center-Durham, Durham VA Health Care System, Durham, NC (B.A.S.); and Harvard Medical School, Boston, Mass (W.B.E.). + + + + Sullivan + Brian A + BA + 0000-0002-7098-6261 + + From the Departments of Radiology (M.C.S.S.H.), Medical School (A.S., A.F.), Medicine (M.V.F.), and Surgery (H.J.M.), Boston University Chobanian & Avedisian School of Medicine, Boston, Mass; Department of Radiology, Boston Medical Center, Boston, Mass (M.C.S.S.H.); Center for Healthcare Organization and Implementation Research (M.F., D.J.S., K.H., R.P.L., W.B.E., H.J.M.), Department of Quality Management (M.V.F.), and Department of Medicine, Section of Infectious Diseases (W.B.E.), VA Boston Healthcare System, 150 S Huntington Ave, Boston, MA 02130; Office of Clinical Affairs, Commonwealth Medicine, University of Massachusetts Chan Medical School, Boston, Mass (N.B.); Department of Gastroenterology, Duke University School of Medicine, Durham, NC (B.A.S.); Cooperative Studies Program Epidemiology Center-Durham, Durham VA Health Care System, Durham, NC (B.A.S.); and Harvard Medical School, Boston, Mass (W.B.E.). + + + + Branch-Elliman + Westyn + W + 0000-0002-9658-5124 + + From the Departments of Radiology (M.C.S.S.H.), Medical School (A.S., A.F.), Medicine (M.V.F.), and Surgery (H.J.M.), Boston University Chobanian & Avedisian School of Medicine, Boston, Mass; Department of Radiology, Boston Medical Center, Boston, Mass (M.C.S.S.H.); Center for Healthcare Organization and Implementation Research (M.F., D.J.S., K.H., R.P.L., W.B.E., H.J.M.), Department of Quality Management (M.V.F.), and Department of Medicine, Section of Infectious Diseases (W.B.E.), VA Boston Healthcare System, 150 S Huntington Ave, Boston, MA 02130; Office of Clinical Affairs, Commonwealth Medicine, University of Massachusetts Chan Medical School, Boston, Mass (N.B.); Department of Gastroenterology, Duke University School of Medicine, Durham, NC (B.A.S.); Cooperative Studies Program Epidemiology Center-Durham, Durham VA Health Care System, Durham, NC (B.A.S.); and Harvard Medical School, Boston, Mass (W.B.E.). + + + + Mull + Hillary J + HJ + 0000-0002-4484-0445 + + From the Departments of Radiology (M.C.S.S.H.), Medical School (A.S., A.F.), Medicine (M.V.F.), and Surgery (H.J.M.), Boston University Chobanian & Avedisian School of Medicine, Boston, Mass; Department of Radiology, Boston Medical Center, Boston, Mass (M.C.S.S.H.); Center for Healthcare Organization and Implementation Research (M.F., D.J.S., K.H., R.P.L., W.B.E., H.J.M.), Department of Quality Management (M.V.F.), and Department of Medicine, Section of Infectious Diseases (W.B.E.), VA Boston Healthcare System, 150 S Huntington Ave, Boston, MA 02130; Office of Clinical Affairs, Commonwealth Medicine, University of Massachusetts Chan Medical School, Boston, Mass (N.B.); Department of Gastroenterology, Duke University School of Medicine, Durham, NC (B.A.S.); Cooperative Studies Program Epidemiology Center-Durham, Durham VA Health Care System, Durham, NC (B.A.S.); and Harvard Medical School, Boston, Mass (W.B.E.). + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Radiology + 0401260 + 0033-8419 + + IM + + + Radiology. 2023 Feb 21;:223330 + 36809221 + + +
+ + + + 2023 + 2 + 22 + 13 + 36 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809217 + 10.1148/radiol.220619 + + +
+ + + 36809210 + + 2023 + 02 + 22 + +
+ + 1537-1611 + + 24 + 3 + + 2023 + Mar + 01 + + + Journal of clinical neuromuscular disease + J Clin Neuromuscul Dis + + Small-Fiber Neuropathy After Vaccination With mRNA-1273 SARS-CoV-2 Vaccine. + + 169-170 + + 10.1097/CND.0000000000000432 + + + Bernheimer + James H + JH + + Mercy Center for Neurology, Mercy Medical Center, Baltimore, MD. + + + + Pan + Baohan + B + + Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD. + + + + Gerecke + Bonnie J + BJ + + Mercy Center for Neurology, Mercy Medical Center, Baltimore, MD. + + + + eng + + Journal Article + + + 2023 + 02 + 16 + +
+ + United States + J Clin Neuromuscul Dis + 100887391 + 1522-0443 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 36 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809210 + 10.1097/CND.0000000000000432 + 00131402-202303000-00012 + + + + Lacomis D. Small-fiber neuropathy. Muscle Nerve. 2002;26:173–188. + + + Abrams RMC, Simpson DM, Navis A, et al. Small fiber neuropathy associated with SARS-CoV-2 infection. Muscle Nerve. 2022;65:440–443. + + + Souayah N, Ajroud-Driss S, Sander HW, et al. Small fiber neuropathy following vaccination for rabies, varicella, or Lyme disease. Vaccine. 2009;27:7322–7325. + + + Waheed W, Carey ME, Tandan SR, et al. Post COVID-19 vaccine small fiber neuropathy. Muscle Nerve. 2021;64:E1–E2. + + + Finsterer J. SARS-CoV-2 vaccinations may not only be complicated by GBS but also by distal small fibre neuropathy. J Neuroimmunol. 2021;360:577703. + + + Centers for Disease Control. COVID-19 Vaccinations in the United States. CDC COVID Data Tracker. Available at: https://covid.cdc.gov/covid-data-tracker/#vaccinations. Accessed May 30, 2022. + + + Vaccine Adverse Effect Reporting System (VAERS). United States Department of Health and Human Services (DHHS), Public Health Service (PHS), Centers for Disease Control (CDC)/Food and Drug Administration (FDA), Vaccine Adverse Reporting System (VAERS) 1990-3/19/2021, CDC Wonder On-line Database. Available at: http://wonder.cdc.gov/vaers.html. Accessed May 30, 2022. + + + +
+ + + 36809207 + + 2023 + 02 + 22 + +
+ + 1537-1611 + + 24 + 3 + + 2023 + Mar + 01 + + + Journal of clinical neuromuscular disease + J Clin Neuromuscul Dis + + Camptocormia as an Unusual Presenting Symptom of Myotonic Dystrophy Type 2: An Overlooked Cause of Axial Myopathy. + + 165-166 + + 10.1097/CND.0000000000000417 + + + Angelopoulou + Efthalia + E + + 1st Department of Neurology, Eginitio University Hospital, National and Kapodistrian University of Athens, Athens, Greece; and. + + + + Karadima + Georgia + G + + Neurogenetics Unit, 1st Department of Neurology, Eginitio University Hospital, National and Kapodistrian University of Athens, Athens, Greece. + + + + Pyrgelis + Efstratios-Stylianos + ES + + 1st Department of Neurology, Eginitio University Hospital, National and Kapodistrian University of Athens, Athens, Greece; and. + + + + Zambelis + Thomas + T + + 1st Department of Neurology, Eginitio University Hospital, National and Kapodistrian University of Athens, Athens, Greece; and. + + + + Zouvelou + Vasiliki + V + + 1st Department of Neurology, Eginitio University Hospital, National and Kapodistrian University of Athens, Athens, Greece; and. + + + + eng + + Journal Article + +
+ + United States + J Clin Neuromuscul Dis + 100887391 + 1522-0443 + + IM + The authors report no conflicts of interest. +
+ + + + 2023 + 2 + 22 + 13 + 36 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809207 + 10.1097/CND.0000000000000417 + 00131402-202303000-00009 + + + + Ali F, Matsumoto JY, Hassan A. Camptocormia: etiology, diagnosis, and treatment response. Neurol Clin Pract. 2018;8:240–248. + + + Schoser B, Timchenko L. Myotonic dystrophies 1 and 2: complex diseases with complex mechanisms. Curr Genomics. 2010;11:77–90. + + + Serratrice J, Weiller PJ, Pouget J, et al. An unrecognized cause of camptocormia: proximal myotonic myopathy [in French]. Presse Med. 2000;29:1121–1123. + + + Rimbaux S, Pellieux S, Bergemer AM, et al. Camptocornia presenting with a proximal myotonic myopathy [in French]. Rev Neurol (Paris). 2003;159:678–680. + + + Kocaaga Z, Bal S, Turan Y, et al. Camptocormia and dropped head syndrome as a clinic picture of myotonic myopathy. Joint Bone Spine. 2008;75:730–733. + + + +
+ + + 36809206 + + 2023 + 02 + 22 + +
+ + 1537-1611 + + 24 + 3 + + 2023 + Mar + 01 + + + Journal of clinical neuromuscular disease + J Clin Neuromuscul Dis + + Head and Neck Squamous Cell Carcinoma Presenting With Leptomeningeal Carcinomatosis and Myeloradiculopathy via Perineural Growth. + + 164-165 + + 10.1097/CND.0000000000000425 + + + San Luis + Carmela V + CV + + Departments of Neurology. + + + + Breaux + Sarah + S + + Departments of Neurology. + + + + Sotoudeh + Houman + H + + Radiology. + + + + Fallon + Kenneth + K + + Pathology, University of Alabama at Birmingham, Birmingham, AL. + + + + Nozaki + Kenkichi + K + 0000-0002-0992-1362 + + Departments of Neurology. + + + + eng + + Journal Article + +
+ + United States + J Clin Neuromuscul Dis + 100887391 + 1522-0443 + + IM + The authors report no conflicts of interest. +
+ + + + 2023 + 2 + 22 + 13 + 36 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809206 + 10.1097/CND.0000000000000425 + 00131402-202303000-00008 + + + + Denaro N, Merlano MC, Russi EG. Follow-up in head and neck cancer: do more does it mean do better? A systematic review and our proposal based on our experience. Clin Exp Otorhinolaryngol. 2016;9:287–297. + + + Pai SI, Westra WH. Molecular pathology of head and neck cancer: implications for diagnosis, prognosis, and treatment. Annu Rev Pathol. 2009;4:49–70. + + + Zammar SG, Hennessy M, Warrick J, et al. Leptomeningeal carcinomatosis from squamous cell carcinoma of the ethmoid sinus: a case report. Cureus 2019;11:e5281. + + + Roh J, Muelleman T, Tawfik O, et al. Perineural growth in head and neck squamous cell carcinoma: a review. Oral Oncol. 2015;51:16–23. + + + Ren S, Huang Y, Shah P, et al. Metastatic squamous cell carcinoma in cerebrospinal fluid: why a rare diagnosis on cytology? Acta Cytol. 2012;56:209–213. + + + +
+ + + 36809219 + + 2023 + 02 + 22 + +
+ + 1527-1315 + + + 2023 + Feb + 21 + + + Radiology + Radiology + + Point-of-Care MRI Shows Great Promise. + + 222071 + + 10.1148/radiol.222071 + + + Ditkofsky + Noah + N + 0000-0002-5851-8166 + + Division of Emergency, Trauma and Acute Care Radiology Department of Medical Imaging, St. Michael's Hospital, Unity Health Toronto, University of Toronto. + + + + Lin + Amy W + AW + 0000-0002-2505-7340 + + Division of Neuroradiology, Department of Medical Imaging, St. Michael's Hospital, Unity Health Toronto, University of Toronto. + + + + Mathur + Shobhit + S + + Division of Emergency, Trauma and Acute Care Radiology Department of Medical Imaging, St. Michael's Hospital, Unity Health Toronto, University of Toronto. + + + Division of Neuroradiology, Department of Medical Imaging, St. Michael's Hospital, Unity Health Toronto, University of Toronto. + + + Medical Imaging Office of Research and Innovation, Li Ka Shing Knowledge Institute, 30 Bond St, Toronto, ON, Canada M5B 1W8. + + + + Bharatha + Aditya + A + 0000-0002-7923-7865 + + Division of Neuroradiology, Department of Medical Imaging, St. Michael's Hospital, Unity Health Toronto, University of Toronto. + + + Medical Imaging Office of Research and Innovation, Li Ka Shing Knowledge Institute, 30 Bond St, Toronto, ON, Canada M5B 1W8. + + + + eng + + Letter + + + 2023 + 02 + 21 + +
+ + United States + Radiology + 0401260 + 0033-8419 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 36 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809219 + 10.1148/radiol.222071 + + +
+ + + 36809222 + + 2023 + 02 + 22 + +
+ + 1940-1574 + + + 2023 + Feb + 21 + + + Angiology + Angiology + + Comparison of Second-Generation Cryoballoon Ablation and Quantitative Radiofrequency Ablation Guided by Ablation Index for Atrial Fibrillation. + + 33197231159254 + + 10.1177/00033197231159254 + + We compared the efficacy and complication rates of quantitative radiofrequency ablation guided by ablation index (RFCA-AI) with those of second-generation cryoballoon ablation (CBA-2). Consecutive patients (n = 230) with symptomatic atrial fibrillation (AF) undergoing a first ablation CBA-2 (92 patients) or RFCA-AI (138 patients) procedure were enrolled in this study. The late recurrence rate in the CBA-2 group was higher than that in the RFCA-AI group (P = .012). Subgroup analysis showed the same result in patients with paroxysmal AF (PAF) (P = .039), but no difference was found in patients with persistent AF (P = .21). The average operation duration in the CBA-2 group (85 [75-99.5] minutes) was shorter than that in the RFCA-AI group (100 [84.5-120] minutes) (P < .0001), but the average exposure time (17.36(13.87-22.49) vs 5.49(4.00-8.24) minutes) in the CBA-2 group and X-ray dose (223.25(149.15-336.95) vs 109.15(80.75-168.7) mGym) were significantly longer than those in RFCA-AI group (P < .0001). Multivariate logistic regression analysis showed that left atrial diameter (LAD), early recurrence, and methods of ablation (cryoballoon ablation) were independent risk factors for late recurrence after AF ablation. Early recurrence of AF and LAD were independent risk factors for predicting late recurrence after AF ablation. + + + + Yan + Qin-Dan + QD + + Department of Rehabilitation, Xiamen Humanity Rehabilitation Hospital, Xiamen, China. + + + + Gong + Ke-Zeng + KZ + + Department of Cardiology, Fujian Heart Medical Center, Fujian Institute of Coronary Heart Disease, Fujian Clinical Medical Research Center for Heart and Macrovascular Diseases, 117890Fujian Medical University Union Hospital, Fuzhou, China. + + + + Chen + Xue-Hai + XH + + Department of Cardiology, Fujian Heart Medical Center, Fujian Institute of Coronary Heart Disease, Fujian Clinical Medical Research Center for Heart and Macrovascular Diseases, 117890Fujian Medical University Union Hospital, Fuzhou, China. + + + + Chen + Jian-Hua + JH + + Department of Cardiology, Fujian Heart Medical Center, Fujian Institute of Coronary Heart Disease, Fujian Clinical Medical Research Center for Heart and Macrovascular Diseases, 117890Fujian Medical University Union Hospital, Fuzhou, China. + + + + Xu + Zhe + Z + + Department of Cardiology, Fujian Heart Medical Center, Fujian Institute of Coronary Heart Disease, Fujian Clinical Medical Research Center for Heart and Macrovascular Diseases, 117890Fujian Medical University Union Hospital, Fuzhou, China. + + + + Wang + Wei-Wei + WW + + Department of Cardiology, Fujian Heart Medical Center, Fujian Institute of Coronary Heart Disease, Fujian Clinical Medical Research Center for Heart and Macrovascular Diseases, 117890Fujian Medical University Union Hospital, Fuzhou, China. + + + + Zhang + Fei-Long + FL + 0000-0002-4995-6615 + + Department of Cardiology, Fujian Heart Medical Center, Fujian Institute of Coronary Heart Disease, Fujian Clinical Medical Research Center for Heart and Macrovascular Diseases, 117890Fujian Medical University Union Hospital, Fuzhou, China. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Angiology + 0203706 + 0003-3197 + + IM + + Atrial fibrillation + ablation index + cryoablation + radiofrequency ablation + second-generation cryoballoon + +
+ + + + 2023 + 2 + 22 + 13 + 36 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809222 + 10.1177/00033197231159254 + + +
+ + + 36809214 + + 2023 + 02 + 22 + +
+ + 1527-1315 + + + 2023 + Feb + 21 + + + Radiology + Radiology + + Diversity and Inclusion in Radiology: A Challenge to Be Faced. + + 222098 + + 10.1148/radiol.222098 + + + Cardona Ortegón + José David + JD + 0000-0003-1647-0800 + + Department of Diagnostic Imaging, Fundación Santa Fe de Bogotá, 116 Street # 9-02, Bogotá, Colombia 110111. + + + + Cifuentes Gaitán + Karen + K + 0000-0002-2729-7460 + + Department of Diagnostic Imaging, Fundación Santa Fe de Bogotá, 116 Street # 9-02, Bogotá, Colombia 110111. + + + + Rueda + María Alejandra + MA + 0000-0002-1673-0329 + + Department of Diagnostic Imaging, Fundación Santa Fe de Bogotá, 116 Street # 9-02, Bogotá, Colombia 110111. + + + + Romero + Javier Andrés + JA + 0000-0003-1193-9980 + + Department of Diagnostic Imaging, Fundación Santa Fe de Bogotá, 116 Street # 9-02, Bogotá, Colombia 110111. + + + + eng + + Letter + + + 2023 + 02 + 21 + +
+ + United States + Radiology + 0401260 + 0033-8419 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 36 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809214 + 10.1148/radiol.222098 + + +
+ + + 36809192 + + 2023 + 02 + 22 + +
+ + 1526-2359 + + 30 + + 2023 Jan-Dec + + + Cancer control : journal of the Moffitt Cancer Center + Cancer Control + + Status and Determinants of Early Detection of Oral Premalignant and Malignant Lesions in India. + + 10732748231159556 + + 10.1177/10732748231159556 + + It has been over four decades since the launch of the National Cancer Control Programme in India, yet the cancer screening rates for oral cancer remain unremarkable. Moreover, India is bracing a large burden of oral cancer with poor survival rates. An effective public health programme implementation relies on a multitude of factors related to cost-effective evidence-based interventions, the healthcare delivery system, public health human resource management, community behaviour, partnership with stakeholders, identifying opportunities and political commitment. In this context, we discuss the various challenges in the early detection of oral premalignant and malignant lesions and potential solutions. + + + + Shruti + Tulika + T + + Departmentof Preventive Oncology, Mahamana Pandit Madan Mohan Malaviya Cancer Centre (MPMMCC) and Homi Bhabha Cancer Hospital (HBCH), Tata Memorial Centres, Varanasi, India. + + + + Khanna + Divya + D + 0000-0001-7856-8059 + + Departmentof Preventive Oncology, Mahamana Pandit Madan Mohan Malaviya Cancer Centre (MPMMCC) and Homi Bhabha Cancer Hospital (HBCH), Tata Memorial Centres, Varanasi, India. + + + + Khan + Aqusa + A + + Departmentof Preventive Oncology, Mahamana Pandit Madan Mohan Malaviya Cancer Centre (MPMMCC) and Homi Bhabha Cancer Hospital (HBCH), Tata Memorial Centres, Varanasi, India. + + + + Dandpat + Abhishek + A + + Departmentof Preventive Oncology, Mahamana Pandit Madan Mohan Malaviya Cancer Centre (MPMMCC) and Homi Bhabha Cancer Hospital (HBCH), Tata Memorial Centres, Varanasi, India. + + + + Tiwari + Manish + M + + Department of Head and Neck Oncology, Mahamana Pandit Madan Mohan Malaviya Cancer Centre (MPMMCC) and Homi Bhabha Cancer Hospital (HBCH), 221116Tata Memorial Centres, Varanasi, India. + + + + Singh + Arjun G + AG + + Department of Head and Neck Oncology, Tata Memorial Centre, Mumbai, India. + + + + Mishra + Aseem + A + + Department of Head and Neck Oncology, Mahamana Pandit Madan Mohan Malaviya Cancer Centre (MPMMCC) and Homi Bhabha Cancer Hospital (HBCH), 221116Tata Memorial Centres, Varanasi, India. + + + + Shetty + Anupama + A + 0000-0002-1033-2848 + + Biocon Foundation, Bengaluru, India. + + + + Birur + Praveen + P + + Department of Oral Medicine and Radiology, Consultant Biocon Foundation and Integrated Head and Neck Programme, Mazumdar Shaw Medical Foundation, KLES Institute of Dental Sciences, Bengaluru, India. + + + + Chaturvedi + Pankaj + P + + Department of Surgical Oncology, Homi Bhabha National Institute, Anushakti Nagar, India. + + + Centre for Cancer Epidemiology, 221116Tata Memorial Centre, Mumbai, India. + + + + eng + + Journal Article + Review + +
+ + United States + Cancer Control + 9438457 + 1073-2748 + + IM + + cancer screening + community health workers + health resources + mobile health + oral cancer + point-of-care + smokeless tobacco + +
+ + + + 2023 + 2 + 22 + 13 + 35 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809192 + 10.1177/10732748231159556 + + +
+ + + 36809213 + + 2023 + 02 + 22 + +
+ + 1527-1315 + + + 2023 + Feb + 21 + + + Radiology + Radiology + + Added Value of Pelvic CT after Treatment of HCC. + + 222314 + + 10.1148/radiol.222314 + + Background In patients with hepatocellular carcinoma (HCC) who undergo follow-up with CT after treatment, the benefit of routinely including pelvic coverage is not well substantiated. Purpose To investigate the added value of pelvic coverage at follow-up liver CT in detecting pelvic metastasis or incidental tumors in patients treated for HCC. Materials and Methods This retrospective study included patients who were diagnosed with HCC between January 2016 and December 2017 and followed up with liver CT after treatment. Cumulative rates of extrahepatic metastasis, isolated pelvic metastasis, and incidental pelvic tumor were estimated by using the Kaplan-Meier method. Cox proportional hazard models were used to identify risk factors for extrahepatic and isolated pelvic metastases. Radiation dose from pelvic coverage was also calculated. Results A total of 1122 patients (mean age, 60 years ± 10 [SD]; 896 men) were included. The cumulative rates at 3 years of extrahepatic metastasis, isolated pelvic metastasis, and incidental pelvic tumor were 14.4%, 1.4%, and 0.5%, respectively. At adjusted analysis, protein induced by vitamin K absence or antagonist-II (P = .001), size of the largest tumor (P = .02), T stage (P = .008), and initial treatment method (P < .001) were associated with extrahepatic metastasis. Only T stage was associated with isolated pelvic metastasis (P = .01). Because of pelvic coverage, the radiation dose increased by 29% and 39% in liver CT with and without contrast enhancement, respectively, compared with CT scans without pelvic coverage. Conclusion The incidence of isolated pelvic metastasis or incidental pelvic tumor was low in patients treated for hepatocellular carcinoma. © RSNA, 2023. + + + + Yeom + Arim + A + 0000-0001-6343-4648 + + From the Department of Radiology, Samsung Medical Center, Sungkyunkwan University, 81 Irwon-Ro, Gangnam-Gu, Seoul 06351, Korea (A.Y., K.D.S.); Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul, Korea (S.A.C.); and Biomedical Statistics Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea (S.A.C.). + + + + Chi + Sang Ah + SA + 0000-0002-4349-5248 + + From the Department of Radiology, Samsung Medical Center, Sungkyunkwan University, 81 Irwon-Ro, Gangnam-Gu, Seoul 06351, Korea (A.Y., K.D.S.); Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul, Korea (S.A.C.); and Biomedical Statistics Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea (S.A.C.). + + + + Song + Kyoung Doo + KD + 0000-0002-2767-3622 + + From the Department of Radiology, Samsung Medical Center, Sungkyunkwan University, 81 Irwon-Ro, Gangnam-Gu, Seoul 06351, Korea (A.Y., K.D.S.); Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul, Korea (S.A.C.); and Biomedical Statistics Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea (S.A.C.). + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Radiology + 0401260 + 0033-8419 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 36 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809213 + 10.1148/radiol.222314 + + +
+ + + 36809221 + + 2023 + 02 + 22 + +
+ + 1527-1315 + + + 2023 + Feb + 21 + + + Radiology + Radiology + + Even in Radiology, Race Matters. + + 223330 + + 10.1148/radiol.223330 + + + Forman + Howard P + HP + 0000-0002-3096-835X + + From the Department of Radiology and Biomedical Imaging, Yale School of Medicine, 333 Cedar St, Tompkins East 2-204, New Haven, CT 06520 (H.P.F., M.A.D.); Yale School of Management, New Haven, Conn (H.P.F.); Yale School of Public Health, New Haven, Conn (H.P.F.); and Economics Department, Yale University, New Haven, Conn (H.P.F.). + + + + Davis + Melissa A + MA + + From the Department of Radiology and Biomedical Imaging, Yale School of Medicine, 333 Cedar St, Tompkins East 2-204, New Haven, CT 06520 (H.P.F., M.A.D.); Yale School of Management, New Haven, Conn (H.P.F.); Yale School of Public Health, New Haven, Conn (H.P.F.); and Economics Department, Yale University, New Haven, Conn (H.P.F.). + + + + eng + + Editorial + Comment + + + 2023 + 02 + 21 + +
+ + United States + Radiology + 0401260 + 0033-8419 + + IM + + + Radiology. 2023 Feb 21;:220619 + 36809217 + + +
+ + + + 2023 + 2 + 22 + 13 + 36 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809221 + 10.1148/radiol.223330 + + +
+ + + 36809216 + + 2023 + 02 + 22 + +
+ + 1527-1315 + + + 2023 + Feb + 21 + + + Radiology + Radiology + + Dermatomyositis-associated Calcinosis Cutis on Digital Breast Tomosynthesis. + + 222173 + + 10.1148/radiol.222173 + + Supplemental material is available for this article. + + + + Fernández + Tomás + T + 0000-0002-8922-2771 + + From the Department of Radiology, Hospital Clínic, Villarroel 170, 08036 Barcelona, Spain. + + + + Ganau + Sergi + S + 0000-0002-6586-1712 + + From the Department of Radiology, Hospital Clínic, Villarroel 170, 08036 Barcelona, Spain. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Radiology + 0401260 + 0033-8419 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 36 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809216 + 10.1148/radiol.222173 + + +
+ + + 36809220 + + 2023 + 02 + 22 + +
+ + 1527-1315 + + + 2023 + Feb + 21 + + + Radiology + Radiology + + Quantification of Liver Iron Overload with MRI: Review and Guidelines from the ESGAR and SAR. + + 221856 + + 10.1148/radiol.221856 + + Accumulation of excess iron in the body, or systemic iron overload, results from a variety of causes. The concentration of iron in the liver is linearly related to the total body iron stores and, for this reason, quantification of liver iron concentration (LIC) is widely regarded as the best surrogate to assess total body iron. Historically assessed using biopsy, there is a clear need for noninvasive quantitative imaging biomarkers of LIC. MRI is highly sensitive to the presence of tissue iron and has been increasingly adopted as a noninvasive alternative to biopsy for detection, severity grading, and treatment monitoring in patients with known or suspected iron overload. Multiple MRI strategies have been developed in the past 2 decades, based on both gradient-echo and spin-echo imaging, including signal intensity ratio and relaxometry strategies. However, there is a general lack of consensus regarding the appropriate use of these methods. The overall goal of this article is to summarize the current state of the art in the clinical use of MRI to quantify liver iron content and to assess the overall level of evidence of these various methods. Based on this summary, expert consensus panel recommendations on best practices for MRI-based quantification of liver iron are provided. + © RSNA, 2023. + + + + Reeder + Scott B + SB + 0000-0003-4728-8171 + + From the Departments of Radiology (S.B.R., D.H.), Medical Physics (S.B.R., D.H.), Biomedical Engineering (S.B.R.), Medicine (S.B.R.), and Emergency Medicine (S.B.R.), University of Wisconsin, Room 2472, 1111 Highland Ave, Madison, WI 53705; Department of Radiology and Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Tex (T.Y.); Department of Radiology, Centro Hospitalar Universitário do Porto, Oporto, Portugal (M.F.); Biomedical Imaging Research Group (GIBI230-PREBI), Instituto de Investigación Sanitaria La Fe, Valencia, Spain (Á.A.B.); Quantitative Imaging Biomarkers in Medicine, Quibim SL, Valencia, Spain (Á.A.B.); Osatek, Magnetic Resonance Unit, Donostia University Hospital, San Sebastián, Spain (J.M.A.); Department of Radiology, University Hospital and University of Rennes 1, Rennes, France (Y.G.); Department of Radiology, Medical University of Innsbruck, Innsbruck, Austria (B.H.); Research Imaging NSW, Division of Research & Enterprise, University of New South Wales, Sydney, Australia (C.H.); Joint Department of Medical Imaging (K.J.) and Department of Medicine (R.W.), University Health Network, University of Toronto, Toronto, Canada; Liver Imaging Team, Department of Radiology, Hacettepe University School of Medicine, Ankara, Turkey (M.K.); Institute and Policlinic for Diagnostic and Interventional Radiology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany (J.P.K.); Department of Radiology, Division of Abdominal Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (A.M.); Department of Radiology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pa (S.D.S.); Division of Pediatric Cardiology, Children's Hospital of Los Angeles, Los Angeles, Calif (J.C.W.); Center of Radiology & Endoscopy, Department of Diagnostic & Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.Y.); and Medical Imaging Department and Biomedical Imaging Research Group, Hospital Universitario y Politécnico La Fe and Health Research Institute, Valencia, Spain (L.M.B.). + + + + Yokoo + Takeshi + T + 0000-0002-5092-6931 + + From the Departments of Radiology (S.B.R., D.H.), Medical Physics (S.B.R., D.H.), Biomedical Engineering (S.B.R.), Medicine (S.B.R.), and Emergency Medicine (S.B.R.), University of Wisconsin, Room 2472, 1111 Highland Ave, Madison, WI 53705; Department of Radiology and Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Tex (T.Y.); Department of Radiology, Centro Hospitalar Universitário do Porto, Oporto, Portugal (M.F.); Biomedical Imaging Research Group (GIBI230-PREBI), Instituto de Investigación Sanitaria La Fe, Valencia, Spain (Á.A.B.); Quantitative Imaging Biomarkers in Medicine, Quibim SL, Valencia, Spain (Á.A.B.); Osatek, Magnetic Resonance Unit, Donostia University Hospital, San Sebastián, Spain (J.M.A.); Department of Radiology, University Hospital and University of Rennes 1, Rennes, France (Y.G.); Department of Radiology, Medical University of Innsbruck, Innsbruck, Austria (B.H.); Research Imaging NSW, Division of Research & Enterprise, University of New South Wales, Sydney, Australia (C.H.); Joint Department of Medical Imaging (K.J.) and Department of Medicine (R.W.), University Health Network, University of Toronto, Toronto, Canada; Liver Imaging Team, Department of Radiology, Hacettepe University School of Medicine, Ankara, Turkey (M.K.); Institute and Policlinic for Diagnostic and Interventional Radiology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany (J.P.K.); Department of Radiology, Division of Abdominal Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (A.M.); Department of Radiology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pa (S.D.S.); Division of Pediatric Cardiology, Children's Hospital of Los Angeles, Los Angeles, Calif (J.C.W.); Center of Radiology & Endoscopy, Department of Diagnostic & Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.Y.); and Medical Imaging Department and Biomedical Imaging Research Group, Hospital Universitario y Politécnico La Fe and Health Research Institute, Valencia, Spain (L.M.B.). + + + + França + Manuela + M + 0000-0003-1068-8577 + + From the Departments of Radiology (S.B.R., D.H.), Medical Physics (S.B.R., D.H.), Biomedical Engineering (S.B.R.), Medicine (S.B.R.), and Emergency Medicine (S.B.R.), University of Wisconsin, Room 2472, 1111 Highland Ave, Madison, WI 53705; Department of Radiology and Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Tex (T.Y.); Department of Radiology, Centro Hospitalar Universitário do Porto, Oporto, Portugal (M.F.); Biomedical Imaging Research Group (GIBI230-PREBI), Instituto de Investigación Sanitaria La Fe, Valencia, Spain (Á.A.B.); Quantitative Imaging Biomarkers in Medicine, Quibim SL, Valencia, Spain (Á.A.B.); Osatek, Magnetic Resonance Unit, Donostia University Hospital, San Sebastián, Spain (J.M.A.); Department of Radiology, University Hospital and University of Rennes 1, Rennes, France (Y.G.); Department of Radiology, Medical University of Innsbruck, Innsbruck, Austria (B.H.); Research Imaging NSW, Division of Research & Enterprise, University of New South Wales, Sydney, Australia (C.H.); Joint Department of Medical Imaging (K.J.) and Department of Medicine (R.W.), University Health Network, University of Toronto, Toronto, Canada; Liver Imaging Team, Department of Radiology, Hacettepe University School of Medicine, Ankara, Turkey (M.K.); Institute and Policlinic for Diagnostic and Interventional Radiology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany (J.P.K.); Department of Radiology, Division of Abdominal Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (A.M.); Department of Radiology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pa (S.D.S.); Division of Pediatric Cardiology, Children's Hospital of Los Angeles, Los Angeles, Calif (J.C.W.); Center of Radiology & Endoscopy, Department of Diagnostic & Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.Y.); and Medical Imaging Department and Biomedical Imaging Research Group, Hospital Universitario y Politécnico La Fe and Health Research Institute, Valencia, Spain (L.M.B.). + + + + Hernando + Diego + D + 0000-0002-0016-0317 + + From the Departments of Radiology (S.B.R., D.H.), Medical Physics (S.B.R., D.H.), Biomedical Engineering (S.B.R.), Medicine (S.B.R.), and Emergency Medicine (S.B.R.), University of Wisconsin, Room 2472, 1111 Highland Ave, Madison, WI 53705; Department of Radiology and Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Tex (T.Y.); Department of Radiology, Centro Hospitalar Universitário do Porto, Oporto, Portugal (M.F.); Biomedical Imaging Research Group (GIBI230-PREBI), Instituto de Investigación Sanitaria La Fe, Valencia, Spain (Á.A.B.); Quantitative Imaging Biomarkers in Medicine, Quibim SL, Valencia, Spain (Á.A.B.); Osatek, Magnetic Resonance Unit, Donostia University Hospital, San Sebastián, Spain (J.M.A.); Department of Radiology, University Hospital and University of Rennes 1, Rennes, France (Y.G.); Department of Radiology, Medical University of Innsbruck, Innsbruck, Austria (B.H.); Research Imaging NSW, Division of Research & Enterprise, University of New South Wales, Sydney, Australia (C.H.); Joint Department of Medical Imaging (K.J.) and Department of Medicine (R.W.), University Health Network, University of Toronto, Toronto, Canada; Liver Imaging Team, Department of Radiology, Hacettepe University School of Medicine, Ankara, Turkey (M.K.); Institute and Policlinic for Diagnostic and Interventional Radiology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany (J.P.K.); Department of Radiology, Division of Abdominal Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (A.M.); Department of Radiology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pa (S.D.S.); Division of Pediatric Cardiology, Children's Hospital of Los Angeles, Los Angeles, Calif (J.C.W.); Center of Radiology & Endoscopy, Department of Diagnostic & Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.Y.); and Medical Imaging Department and Biomedical Imaging Research Group, Hospital Universitario y Politécnico La Fe and Health Research Institute, Valencia, Spain (L.M.B.). + + + + Alberich-Bayarri + Ángel + Á + 0000-0002-5932-2392 + + From the Departments of Radiology (S.B.R., D.H.), Medical Physics (S.B.R., D.H.), Biomedical Engineering (S.B.R.), Medicine (S.B.R.), and Emergency Medicine (S.B.R.), University of Wisconsin, Room 2472, 1111 Highland Ave, Madison, WI 53705; Department of Radiology and Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Tex (T.Y.); Department of Radiology, Centro Hospitalar Universitário do Porto, Oporto, Portugal (M.F.); Biomedical Imaging Research Group (GIBI230-PREBI), Instituto de Investigación Sanitaria La Fe, Valencia, Spain (Á.A.B.); Quantitative Imaging Biomarkers in Medicine, Quibim SL, Valencia, Spain (Á.A.B.); Osatek, Magnetic Resonance Unit, Donostia University Hospital, San Sebastián, Spain (J.M.A.); Department of Radiology, University Hospital and University of Rennes 1, Rennes, France (Y.G.); Department of Radiology, Medical University of Innsbruck, Innsbruck, Austria (B.H.); Research Imaging NSW, Division of Research & Enterprise, University of New South Wales, Sydney, Australia (C.H.); Joint Department of Medical Imaging (K.J.) and Department of Medicine (R.W.), University Health Network, University of Toronto, Toronto, Canada; Liver Imaging Team, Department of Radiology, Hacettepe University School of Medicine, Ankara, Turkey (M.K.); Institute and Policlinic for Diagnostic and Interventional Radiology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany (J.P.K.); Department of Radiology, Division of Abdominal Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (A.M.); Department of Radiology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pa (S.D.S.); Division of Pediatric Cardiology, Children's Hospital of Los Angeles, Los Angeles, Calif (J.C.W.); Center of Radiology & Endoscopy, Department of Diagnostic & Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.Y.); and Medical Imaging Department and Biomedical Imaging Research Group, Hospital Universitario y Politécnico La Fe and Health Research Institute, Valencia, Spain (L.M.B.). + + + + Alústiza + José María + JM + 0000-0002-0056-3829 + + From the Departments of Radiology (S.B.R., D.H.), Medical Physics (S.B.R., D.H.), Biomedical Engineering (S.B.R.), Medicine (S.B.R.), and Emergency Medicine (S.B.R.), University of Wisconsin, Room 2472, 1111 Highland Ave, Madison, WI 53705; Department of Radiology and Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Tex (T.Y.); Department of Radiology, Centro Hospitalar Universitário do Porto, Oporto, Portugal (M.F.); Biomedical Imaging Research Group (GIBI230-PREBI), Instituto de Investigación Sanitaria La Fe, Valencia, Spain (Á.A.B.); Quantitative Imaging Biomarkers in Medicine, Quibim SL, Valencia, Spain (Á.A.B.); Osatek, Magnetic Resonance Unit, Donostia University Hospital, San Sebastián, Spain (J.M.A.); Department of Radiology, University Hospital and University of Rennes 1, Rennes, France (Y.G.); Department of Radiology, Medical University of Innsbruck, Innsbruck, Austria (B.H.); Research Imaging NSW, Division of Research & Enterprise, University of New South Wales, Sydney, Australia (C.H.); Joint Department of Medical Imaging (K.J.) and Department of Medicine (R.W.), University Health Network, University of Toronto, Toronto, Canada; Liver Imaging Team, Department of Radiology, Hacettepe University School of Medicine, Ankara, Turkey (M.K.); Institute and Policlinic for Diagnostic and Interventional Radiology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany (J.P.K.); Department of Radiology, Division of Abdominal Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (A.M.); Department of Radiology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pa (S.D.S.); Division of Pediatric Cardiology, Children's Hospital of Los Angeles, Los Angeles, Calif (J.C.W.); Center of Radiology & Endoscopy, Department of Diagnostic & Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.Y.); and Medical Imaging Department and Biomedical Imaging Research Group, Hospital Universitario y Politécnico La Fe and Health Research Institute, Valencia, Spain (L.M.B.). + + + + Gandon + Yves + Y + 0000-0002-7729-6087 + + From the Departments of Radiology (S.B.R., D.H.), Medical Physics (S.B.R., D.H.), Biomedical Engineering (S.B.R.), Medicine (S.B.R.), and Emergency Medicine (S.B.R.), University of Wisconsin, Room 2472, 1111 Highland Ave, Madison, WI 53705; Department of Radiology and Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Tex (T.Y.); Department of Radiology, Centro Hospitalar Universitário do Porto, Oporto, Portugal (M.F.); Biomedical Imaging Research Group (GIBI230-PREBI), Instituto de Investigación Sanitaria La Fe, Valencia, Spain (Á.A.B.); Quantitative Imaging Biomarkers in Medicine, Quibim SL, Valencia, Spain (Á.A.B.); Osatek, Magnetic Resonance Unit, Donostia University Hospital, San Sebastián, Spain (J.M.A.); Department of Radiology, University Hospital and University of Rennes 1, Rennes, France (Y.G.); Department of Radiology, Medical University of Innsbruck, Innsbruck, Austria (B.H.); Research Imaging NSW, Division of Research & Enterprise, University of New South Wales, Sydney, Australia (C.H.); Joint Department of Medical Imaging (K.J.) and Department of Medicine (R.W.), University Health Network, University of Toronto, Toronto, Canada; Liver Imaging Team, Department of Radiology, Hacettepe University School of Medicine, Ankara, Turkey (M.K.); Institute and Policlinic for Diagnostic and Interventional Radiology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany (J.P.K.); Department of Radiology, Division of Abdominal Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (A.M.); Department of Radiology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pa (S.D.S.); Division of Pediatric Cardiology, Children's Hospital of Los Angeles, Los Angeles, Calif (J.C.W.); Center of Radiology & Endoscopy, Department of Diagnostic & Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.Y.); and Medical Imaging Department and Biomedical Imaging Research Group, Hospital Universitario y Politécnico La Fe and Health Research Institute, Valencia, Spain (L.M.B.). + + + + Henninger + Benjamin + B + 0000-0003-2872-840X + + From the Departments of Radiology (S.B.R., D.H.), Medical Physics (S.B.R., D.H.), Biomedical Engineering (S.B.R.), Medicine (S.B.R.), and Emergency Medicine (S.B.R.), University of Wisconsin, Room 2472, 1111 Highland Ave, Madison, WI 53705; Department of Radiology and Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Tex (T.Y.); Department of Radiology, Centro Hospitalar Universitário do Porto, Oporto, Portugal (M.F.); Biomedical Imaging Research Group (GIBI230-PREBI), Instituto de Investigación Sanitaria La Fe, Valencia, Spain (Á.A.B.); Quantitative Imaging Biomarkers in Medicine, Quibim SL, Valencia, Spain (Á.A.B.); Osatek, Magnetic Resonance Unit, Donostia University Hospital, San Sebastián, Spain (J.M.A.); Department of Radiology, University Hospital and University of Rennes 1, Rennes, France (Y.G.); Department of Radiology, Medical University of Innsbruck, Innsbruck, Austria (B.H.); Research Imaging NSW, Division of Research & Enterprise, University of New South Wales, Sydney, Australia (C.H.); Joint Department of Medical Imaging (K.J.) and Department of Medicine (R.W.), University Health Network, University of Toronto, Toronto, Canada; Liver Imaging Team, Department of Radiology, Hacettepe University School of Medicine, Ankara, Turkey (M.K.); Institute and Policlinic for Diagnostic and Interventional Radiology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany (J.P.K.); Department of Radiology, Division of Abdominal Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (A.M.); Department of Radiology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pa (S.D.S.); Division of Pediatric Cardiology, Children's Hospital of Los Angeles, Los Angeles, Calif (J.C.W.); Center of Radiology & Endoscopy, Department of Diagnostic & Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.Y.); and Medical Imaging Department and Biomedical Imaging Research Group, Hospital Universitario y Politécnico La Fe and Health Research Institute, Valencia, Spain (L.M.B.). + + + + Hillenbrand + Claudia + C + 0000-0001-8694-2178 + + From the Departments of Radiology (S.B.R., D.H.), Medical Physics (S.B.R., D.H.), Biomedical Engineering (S.B.R.), Medicine (S.B.R.), and Emergency Medicine (S.B.R.), University of Wisconsin, Room 2472, 1111 Highland Ave, Madison, WI 53705; Department of Radiology and Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Tex (T.Y.); Department of Radiology, Centro Hospitalar Universitário do Porto, Oporto, Portugal (M.F.); Biomedical Imaging Research Group (GIBI230-PREBI), Instituto de Investigación Sanitaria La Fe, Valencia, Spain (Á.A.B.); Quantitative Imaging Biomarkers in Medicine, Quibim SL, Valencia, Spain (Á.A.B.); Osatek, Magnetic Resonance Unit, Donostia University Hospital, San Sebastián, Spain (J.M.A.); Department of Radiology, University Hospital and University of Rennes 1, Rennes, France (Y.G.); Department of Radiology, Medical University of Innsbruck, Innsbruck, Austria (B.H.); Research Imaging NSW, Division of Research & Enterprise, University of New South Wales, Sydney, Australia (C.H.); Joint Department of Medical Imaging (K.J.) and Department of Medicine (R.W.), University Health Network, University of Toronto, Toronto, Canada; Liver Imaging Team, Department of Radiology, Hacettepe University School of Medicine, Ankara, Turkey (M.K.); Institute and Policlinic for Diagnostic and Interventional Radiology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany (J.P.K.); Department of Radiology, Division of Abdominal Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (A.M.); Department of Radiology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pa (S.D.S.); Division of Pediatric Cardiology, Children's Hospital of Los Angeles, Los Angeles, Calif (J.C.W.); Center of Radiology & Endoscopy, Department of Diagnostic & Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.Y.); and Medical Imaging Department and Biomedical Imaging Research Group, Hospital Universitario y Politécnico La Fe and Health Research Institute, Valencia, Spain (L.M.B.). + + + + Jhaveri + Kartik + K + + From the Departments of Radiology (S.B.R., D.H.), Medical Physics (S.B.R., D.H.), Biomedical Engineering (S.B.R.), Medicine (S.B.R.), and Emergency Medicine (S.B.R.), University of Wisconsin, Room 2472, 1111 Highland Ave, Madison, WI 53705; Department of Radiology and Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Tex (T.Y.); Department of Radiology, Centro Hospitalar Universitário do Porto, Oporto, Portugal (M.F.); Biomedical Imaging Research Group (GIBI230-PREBI), Instituto de Investigación Sanitaria La Fe, Valencia, Spain (Á.A.B.); Quantitative Imaging Biomarkers in Medicine, Quibim SL, Valencia, Spain (Á.A.B.); Osatek, Magnetic Resonance Unit, Donostia University Hospital, San Sebastián, Spain (J.M.A.); Department of Radiology, University Hospital and University of Rennes 1, Rennes, France (Y.G.); Department of Radiology, Medical University of Innsbruck, Innsbruck, Austria (B.H.); Research Imaging NSW, Division of Research & Enterprise, University of New South Wales, Sydney, Australia (C.H.); Joint Department of Medical Imaging (K.J.) and Department of Medicine (R.W.), University Health Network, University of Toronto, Toronto, Canada; Liver Imaging Team, Department of Radiology, Hacettepe University School of Medicine, Ankara, Turkey (M.K.); Institute and Policlinic for Diagnostic and Interventional Radiology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany (J.P.K.); Department of Radiology, Division of Abdominal Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (A.M.); Department of Radiology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pa (S.D.S.); Division of Pediatric Cardiology, Children's Hospital of Los Angeles, Los Angeles, Calif (J.C.W.); Center of Radiology & Endoscopy, Department of Diagnostic & Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.Y.); and Medical Imaging Department and Biomedical Imaging Research Group, Hospital Universitario y Politécnico La Fe and Health Research Institute, Valencia, Spain (L.M.B.). + + + + Karçaaltıncaba + Musturay + M + 0000-0002-3384-0909 + + From the Departments of Radiology (S.B.R., D.H.), Medical Physics (S.B.R., D.H.), Biomedical Engineering (S.B.R.), Medicine (S.B.R.), and Emergency Medicine (S.B.R.), University of Wisconsin, Room 2472, 1111 Highland Ave, Madison, WI 53705; Department of Radiology and Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Tex (T.Y.); Department of Radiology, Centro Hospitalar Universitário do Porto, Oporto, Portugal (M.F.); Biomedical Imaging Research Group (GIBI230-PREBI), Instituto de Investigación Sanitaria La Fe, Valencia, Spain (Á.A.B.); Quantitative Imaging Biomarkers in Medicine, Quibim SL, Valencia, Spain (Á.A.B.); Osatek, Magnetic Resonance Unit, Donostia University Hospital, San Sebastián, Spain (J.M.A.); Department of Radiology, University Hospital and University of Rennes 1, Rennes, France (Y.G.); Department of Radiology, Medical University of Innsbruck, Innsbruck, Austria (B.H.); Research Imaging NSW, Division of Research & Enterprise, University of New South Wales, Sydney, Australia (C.H.); Joint Department of Medical Imaging (K.J.) and Department of Medicine (R.W.), University Health Network, University of Toronto, Toronto, Canada; Liver Imaging Team, Department of Radiology, Hacettepe University School of Medicine, Ankara, Turkey (M.K.); Institute and Policlinic for Diagnostic and Interventional Radiology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany (J.P.K.); Department of Radiology, Division of Abdominal Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (A.M.); Department of Radiology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pa (S.D.S.); Division of Pediatric Cardiology, Children's Hospital of Los Angeles, Los Angeles, Calif (J.C.W.); Center of Radiology & Endoscopy, Department of Diagnostic & Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.Y.); and Medical Imaging Department and Biomedical Imaging Research Group, Hospital Universitario y Politécnico La Fe and Health Research Institute, Valencia, Spain (L.M.B.). + + + + Kühn + Jens-Peter + JP + 0000-0003-3258-930X + + From the Departments of Radiology (S.B.R., D.H.), Medical Physics (S.B.R., D.H.), Biomedical Engineering (S.B.R.), Medicine (S.B.R.), and Emergency Medicine (S.B.R.), University of Wisconsin, Room 2472, 1111 Highland Ave, Madison, WI 53705; Department of Radiology and Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Tex (T.Y.); Department of Radiology, Centro Hospitalar Universitário do Porto, Oporto, Portugal (M.F.); Biomedical Imaging Research Group (GIBI230-PREBI), Instituto de Investigación Sanitaria La Fe, Valencia, Spain (Á.A.B.); Quantitative Imaging Biomarkers in Medicine, Quibim SL, Valencia, Spain (Á.A.B.); Osatek, Magnetic Resonance Unit, Donostia University Hospital, San Sebastián, Spain (J.M.A.); Department of Radiology, University Hospital and University of Rennes 1, Rennes, France (Y.G.); Department of Radiology, Medical University of Innsbruck, Innsbruck, Austria (B.H.); Research Imaging NSW, Division of Research & Enterprise, University of New South Wales, Sydney, Australia (C.H.); Joint Department of Medical Imaging (K.J.) and Department of Medicine (R.W.), University Health Network, University of Toronto, Toronto, Canada; Liver Imaging Team, Department of Radiology, Hacettepe University School of Medicine, Ankara, Turkey (M.K.); Institute and Policlinic for Diagnostic and Interventional Radiology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany (J.P.K.); Department of Radiology, Division of Abdominal Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (A.M.); Department of Radiology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pa (S.D.S.); Division of Pediatric Cardiology, Children's Hospital of Los Angeles, Los Angeles, Calif (J.C.W.); Center of Radiology & Endoscopy, Department of Diagnostic & Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.Y.); and Medical Imaging Department and Biomedical Imaging Research Group, Hospital Universitario y Politécnico La Fe and Health Research Institute, Valencia, Spain (L.M.B.). + + + + Mojtahed + Amirkasra + A + 0000-0003-1879-9255 + + From the Departments of Radiology (S.B.R., D.H.), Medical Physics (S.B.R., D.H.), Biomedical Engineering (S.B.R.), Medicine (S.B.R.), and Emergency Medicine (S.B.R.), University of Wisconsin, Room 2472, 1111 Highland Ave, Madison, WI 53705; Department of Radiology and Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Tex (T.Y.); Department of Radiology, Centro Hospitalar Universitário do Porto, Oporto, Portugal (M.F.); Biomedical Imaging Research Group (GIBI230-PREBI), Instituto de Investigación Sanitaria La Fe, Valencia, Spain (Á.A.B.); Quantitative Imaging Biomarkers in Medicine, Quibim SL, Valencia, Spain (Á.A.B.); Osatek, Magnetic Resonance Unit, Donostia University Hospital, San Sebastián, Spain (J.M.A.); Department of Radiology, University Hospital and University of Rennes 1, Rennes, France (Y.G.); Department of Radiology, Medical University of Innsbruck, Innsbruck, Austria (B.H.); Research Imaging NSW, Division of Research & Enterprise, University of New South Wales, Sydney, Australia (C.H.); Joint Department of Medical Imaging (K.J.) and Department of Medicine (R.W.), University Health Network, University of Toronto, Toronto, Canada; Liver Imaging Team, Department of Radiology, Hacettepe University School of Medicine, Ankara, Turkey (M.K.); Institute and Policlinic for Diagnostic and Interventional Radiology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany (J.P.K.); Department of Radiology, Division of Abdominal Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (A.M.); Department of Radiology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pa (S.D.S.); Division of Pediatric Cardiology, Children's Hospital of Los Angeles, Los Angeles, Calif (J.C.W.); Center of Radiology & Endoscopy, Department of Diagnostic & Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.Y.); and Medical Imaging Department and Biomedical Imaging Research Group, Hospital Universitario y Politécnico La Fe and Health Research Institute, Valencia, Spain (L.M.B.). + + + + Serai + Suraj D + SD + + From the Departments of Radiology (S.B.R., D.H.), Medical Physics (S.B.R., D.H.), Biomedical Engineering (S.B.R.), Medicine (S.B.R.), and Emergency Medicine (S.B.R.), University of Wisconsin, Room 2472, 1111 Highland Ave, Madison, WI 53705; Department of Radiology and Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Tex (T.Y.); Department of Radiology, Centro Hospitalar Universitário do Porto, Oporto, Portugal (M.F.); Biomedical Imaging Research Group (GIBI230-PREBI), Instituto de Investigación Sanitaria La Fe, Valencia, Spain (Á.A.B.); Quantitative Imaging Biomarkers in Medicine, Quibim SL, Valencia, Spain (Á.A.B.); Osatek, Magnetic Resonance Unit, Donostia University Hospital, San Sebastián, Spain (J.M.A.); Department of Radiology, University Hospital and University of Rennes 1, Rennes, France (Y.G.); Department of Radiology, Medical University of Innsbruck, Innsbruck, Austria (B.H.); Research Imaging NSW, Division of Research & Enterprise, University of New South Wales, Sydney, Australia (C.H.); Joint Department of Medical Imaging (K.J.) and Department of Medicine (R.W.), University Health Network, University of Toronto, Toronto, Canada; Liver Imaging Team, Department of Radiology, Hacettepe University School of Medicine, Ankara, Turkey (M.K.); Institute and Policlinic for Diagnostic and Interventional Radiology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany (J.P.K.); Department of Radiology, Division of Abdominal Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (A.M.); Department of Radiology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pa (S.D.S.); Division of Pediatric Cardiology, Children's Hospital of Los Angeles, Los Angeles, Calif (J.C.W.); Center of Radiology & Endoscopy, Department of Diagnostic & Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.Y.); and Medical Imaging Department and Biomedical Imaging Research Group, Hospital Universitario y Politécnico La Fe and Health Research Institute, Valencia, Spain (L.M.B.). + + + + Ward + Richard + R + 0000-0002-4807-8603 + + From the Departments of Radiology (S.B.R., D.H.), Medical Physics (S.B.R., D.H.), Biomedical Engineering (S.B.R.), Medicine (S.B.R.), and Emergency Medicine (S.B.R.), University of Wisconsin, Room 2472, 1111 Highland Ave, Madison, WI 53705; Department of Radiology and Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Tex (T.Y.); Department of Radiology, Centro Hospitalar Universitário do Porto, Oporto, Portugal (M.F.); Biomedical Imaging Research Group (GIBI230-PREBI), Instituto de Investigación Sanitaria La Fe, Valencia, Spain (Á.A.B.); Quantitative Imaging Biomarkers in Medicine, Quibim SL, Valencia, Spain (Á.A.B.); Osatek, Magnetic Resonance Unit, Donostia University Hospital, San Sebastián, Spain (J.M.A.); Department of Radiology, University Hospital and University of Rennes 1, Rennes, France (Y.G.); Department of Radiology, Medical University of Innsbruck, Innsbruck, Austria (B.H.); Research Imaging NSW, Division of Research & Enterprise, University of New South Wales, Sydney, Australia (C.H.); Joint Department of Medical Imaging (K.J.) and Department of Medicine (R.W.), University Health Network, University of Toronto, Toronto, Canada; Liver Imaging Team, Department of Radiology, Hacettepe University School of Medicine, Ankara, Turkey (M.K.); Institute and Policlinic for Diagnostic and Interventional Radiology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany (J.P.K.); Department of Radiology, Division of Abdominal Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (A.M.); Department of Radiology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pa (S.D.S.); Division of Pediatric Cardiology, Children's Hospital of Los Angeles, Los Angeles, Calif (J.C.W.); Center of Radiology & Endoscopy, Department of Diagnostic & Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.Y.); and Medical Imaging Department and Biomedical Imaging Research Group, Hospital Universitario y Politécnico La Fe and Health Research Institute, Valencia, Spain (L.M.B.). + + + + Wood + John C + JC + + From the Departments of Radiology (S.B.R., D.H.), Medical Physics (S.B.R., D.H.), Biomedical Engineering (S.B.R.), Medicine (S.B.R.), and Emergency Medicine (S.B.R.), University of Wisconsin, Room 2472, 1111 Highland Ave, Madison, WI 53705; Department of Radiology and Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Tex (T.Y.); Department of Radiology, Centro Hospitalar Universitário do Porto, Oporto, Portugal (M.F.); Biomedical Imaging Research Group (GIBI230-PREBI), Instituto de Investigación Sanitaria La Fe, Valencia, Spain (Á.A.B.); Quantitative Imaging Biomarkers in Medicine, Quibim SL, Valencia, Spain (Á.A.B.); Osatek, Magnetic Resonance Unit, Donostia University Hospital, San Sebastián, Spain (J.M.A.); Department of Radiology, University Hospital and University of Rennes 1, Rennes, France (Y.G.); Department of Radiology, Medical University of Innsbruck, Innsbruck, Austria (B.H.); Research Imaging NSW, Division of Research & Enterprise, University of New South Wales, Sydney, Australia (C.H.); Joint Department of Medical Imaging (K.J.) and Department of Medicine (R.W.), University Health Network, University of Toronto, Toronto, Canada; Liver Imaging Team, Department of Radiology, Hacettepe University School of Medicine, Ankara, Turkey (M.K.); Institute and Policlinic for Diagnostic and Interventional Radiology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany (J.P.K.); Department of Radiology, Division of Abdominal Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (A.M.); Department of Radiology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pa (S.D.S.); Division of Pediatric Cardiology, Children's Hospital of Los Angeles, Los Angeles, Calif (J.C.W.); Center of Radiology & Endoscopy, Department of Diagnostic & Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.Y.); and Medical Imaging Department and Biomedical Imaging Research Group, Hospital Universitario y Politécnico La Fe and Health Research Institute, Valencia, Spain (L.M.B.). + + + + Yamamura + Jin + J + 0000-0003-3990-5125 + + From the Departments of Radiology (S.B.R., D.H.), Medical Physics (S.B.R., D.H.), Biomedical Engineering (S.B.R.), Medicine (S.B.R.), and Emergency Medicine (S.B.R.), University of Wisconsin, Room 2472, 1111 Highland Ave, Madison, WI 53705; Department of Radiology and Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Tex (T.Y.); Department of Radiology, Centro Hospitalar Universitário do Porto, Oporto, Portugal (M.F.); Biomedical Imaging Research Group (GIBI230-PREBI), Instituto de Investigación Sanitaria La Fe, Valencia, Spain (Á.A.B.); Quantitative Imaging Biomarkers in Medicine, Quibim SL, Valencia, Spain (Á.A.B.); Osatek, Magnetic Resonance Unit, Donostia University Hospital, San Sebastián, Spain (J.M.A.); Department of Radiology, University Hospital and University of Rennes 1, Rennes, France (Y.G.); Department of Radiology, Medical University of Innsbruck, Innsbruck, Austria (B.H.); Research Imaging NSW, Division of Research & Enterprise, University of New South Wales, Sydney, Australia (C.H.); Joint Department of Medical Imaging (K.J.) and Department of Medicine (R.W.), University Health Network, University of Toronto, Toronto, Canada; Liver Imaging Team, Department of Radiology, Hacettepe University School of Medicine, Ankara, Turkey (M.K.); Institute and Policlinic for Diagnostic and Interventional Radiology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany (J.P.K.); Department of Radiology, Division of Abdominal Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (A.M.); Department of Radiology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pa (S.D.S.); Division of Pediatric Cardiology, Children's Hospital of Los Angeles, Los Angeles, Calif (J.C.W.); Center of Radiology & Endoscopy, Department of Diagnostic & Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.Y.); and Medical Imaging Department and Biomedical Imaging Research Group, Hospital Universitario y Politécnico La Fe and Health Research Institute, Valencia, Spain (L.M.B.). + + + + Martí-Bonmatí + Luis + L + 0000-0002-8234-010X + + From the Departments of Radiology (S.B.R., D.H.), Medical Physics (S.B.R., D.H.), Biomedical Engineering (S.B.R.), Medicine (S.B.R.), and Emergency Medicine (S.B.R.), University of Wisconsin, Room 2472, 1111 Highland Ave, Madison, WI 53705; Department of Radiology and Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Tex (T.Y.); Department of Radiology, Centro Hospitalar Universitário do Porto, Oporto, Portugal (M.F.); Biomedical Imaging Research Group (GIBI230-PREBI), Instituto de Investigación Sanitaria La Fe, Valencia, Spain (Á.A.B.); Quantitative Imaging Biomarkers in Medicine, Quibim SL, Valencia, Spain (Á.A.B.); Osatek, Magnetic Resonance Unit, Donostia University Hospital, San Sebastián, Spain (J.M.A.); Department of Radiology, University Hospital and University of Rennes 1, Rennes, France (Y.G.); Department of Radiology, Medical University of Innsbruck, Innsbruck, Austria (B.H.); Research Imaging NSW, Division of Research & Enterprise, University of New South Wales, Sydney, Australia (C.H.); Joint Department of Medical Imaging (K.J.) and Department of Medicine (R.W.), University Health Network, University of Toronto, Toronto, Canada; Liver Imaging Team, Department of Radiology, Hacettepe University School of Medicine, Ankara, Turkey (M.K.); Institute and Policlinic for Diagnostic and Interventional Radiology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany (J.P.K.); Department of Radiology, Division of Abdominal Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (A.M.); Department of Radiology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pa (S.D.S.); Division of Pediatric Cardiology, Children's Hospital of Los Angeles, Los Angeles, Calif (J.C.W.); Center of Radiology & Endoscopy, Department of Diagnostic & Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.Y.); and Medical Imaging Department and Biomedical Imaging Research Group, Hospital Universitario y Politécnico La Fe and Health Research Institute, Valencia, Spain (L.M.B.). + + + + eng + + Journal Article + Review + + + 2023 + 02 + 21 + +
+ + United States + Radiology + 0401260 + 0033-8419 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 36 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809220 + 10.1148/radiol.221856 + + +
+ + + 36809212 + + 2023 + 02 + 22 + +
+ + 1540-0514 + + + 2023 + Feb + 22 + + + Shock (Augusta, Ga.) + Shock + + Effects of SARS COVID-19 positivity status on venous thrombosis and pulmonary embolism rates in trauma patients. + 10.1097/SHK.0000000000002097 + + COVID-19 Induced Coagulopathy (CIC) can increase the risk of thromboembolism without underlying clotting disorders, even when compared to other respiratory viruses. Trauma has a known association with hypercoagulability. Trauma patients with concurrent COVID-19 infection potentially have an even greater risk of thrombotic events. The purpose of this study was to evaluate venous thromboembolism (VTE) rates in trauma patients with COVID-19. + This study reviewed all adult patients (> 18 years of age) admitted to the Trauma Service from April through November 2020 for a minimum of 48 hours. Patients were grouped based off COVID-19 status and compared for inpatient VTE chemoprophylaxis regimen, thrombotic complications defined as DVT, PE, myocardial infarction, and cerebrovascular accident, ICU length of stay, hospital length of stay, and mortality. + A total of 2907 patients were reviewed and grouped into COVID-19 positive (n = 110) and COVID-19 negative (n = 2797) groups. There was no difference in terms of receiving DVT chemoprophylaxis or type, but a longer time to initiation in the positive group (p = 0.0012). VTE occurred in 5 (4.55%) positive and 60 (2.15%) negative patients without a significant difference between the groups, as well as no difference in type of VTE observed. Mortality was higher (p = 0.009) in the positive group (10.91%). Positive patients had longer median ICU LOS (p = 0.0012) and total LOS (p < 0.001). + There were no increased rates of VTE complications between COVID-19 positive and negative trauma patients, despite a longer time to initiation of chemoprophylaxis in the COVID-19 positive group. COVID-19 positive patients had increased ICU LOS, total LOS, and mortality, which are likely due to multifactorial causes but primarily related to their underlying COVID-19 infection. + Copyright © 2023 by the Shock Society. + + + + Kenney + Connor L + CL + + Brooke Army Medical Center, Fort Sam Houston, Texas, USA. + + + + Nelson + Austin R + AR + + Uniformed Services University of Health Sciences, Bethesda, Maryland, USA. + + + + Fahey + Ryan A + RA + + Brooke Army Medical Center, Fort Sam Houston, Texas, USA. + + + + Roubik + Daniel J + DJ + + Harborview Medical Center, Seattle, Washington, USA. + + + + How + Remealle A + RA + + + Radowsky + Jason S + JS + + + Sams + Valerie G + VG + + + Schauer + Steven G + SG + + United States Army Institute of Surgical Research, Fort Sam Houston, Texas, USA. + + + + Rizzo + Julie A + JA + + + eng + + Journal Article + + + 2023 + 02 + 22 + +
+ + United States + Shock + 9421564 + 1073-2322 + + IM + Conflicts of Interest: The authors report no conflict of interest. +
+ + + + 2023 + 2 + 22 + 13 + 36 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809212 + 10.1097/SHK.0000000000002097 + 00024382-990000000-00154 + + +
+ + + 36809209 + + 2023 + 02 + 22 + +
+ + 1537-1611 + + 24 + 3 + + 2023 + Mar + 01 + + + Journal of clinical neuromuscular disease + J Clin Neuromuscul Dis + + Refractory Seronegative Immune-Mediated Necrotizing Myopathy After Receiving mRNA-1273 SARS-CoV-2 Vaccine: A Case Report. + + 168-169 + + 10.1097/CND.0000000000000431 + + + Chang + Chin-Hen + CH + 0000-0002-8849-5399 + + Department of Physical Medicine and Rehabilitation, Reading Hospital-Tower Health, Reading, PA. + + + + Gupta + Riju + R + + Department of Internal Medicine, Reading Hospital-Tower Health, Reading, PA. + + + + Setyono + Devy + D + + Reading Hospital-Tower Health, Reading, PA. + + + + Cuevas-Ocampo + Areli K + AK + + Department of Pathology and Translational Pathobiology, Louisiana State University Shreveport, LO. + + + + Khoshnoodi + Mohammad A + MA + + Department of Neurology, Reading Hospital-Tower Health, Reading, PA. + + + + eng + + Journal Article + +
+ + United States + J Clin Neuromuscul Dis + 100887391 + 1522-0443 + + IM + The authors report no conflicts of interest. +
+ + + + 2022 + 07 + 13 + + + 2022 + 07 + 26 + + + 2023 + 2 + 22 + 13 + 36 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809209 + 10.1097/CND.0000000000000431 + 00131402-202303000-00011 + + + + Allenbach Y, Benveniste O, Stenzel W, et al. Immune-mediated necrotizing myopathy: clinical features and pathogenesis. Nat Rev Rheumatol. 2020;16:689–701. + + + Dalakas MC. Inflammatory myopathies: update on diagnosis, pathogenesis and therapies, and COVID-19-related implications. Acta Myol. 2020;39:289–301. + + + Wang MY, Zhao R, Gao LJ, et al. SARS-CoV-2: structure, biology, and structure-based therapeutics development. Front Cell Infect Microbiol. 2020;10:587269. + + + Kassardjian CD, Lennon VA, Alfugham NB, et al. Clinical features and treatment outcomes of necrotizing autoimmune myopathy. JAMA Neurol. 2015;72:996–1003. + + + Marotta DA, Zadourian A, Jabaay MJ, et al. Autoantibody-negative immune-mediated necrotizing myopathy responds to early and aggressive treatment: a case report. Cureus. 2020;12:e7827. + + + +
+ + + 36809211 + + 2023 + 02 + 22 + +
+ + 1715-5320 + + + 2023 + Feb + 21 + + + Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme + Appl Physiol Nutr Metab + + Folic acid protects against age-associated apoptosis and telomere attrition of neural stem cells in senescence-accelerated mouse prone 8. + 10.1139/apnm-2022-0111 + + Folic acid (FA) could improve cognitive performances and attenuate brain cell injury in the aging brain, FA supplementation is also associated with inhibiting neural stem cells (NSCs) apoptosis. However, its role in age-associated telomere attrition remains unclear. We hypothesized that FA supplementation attenuates age-associated apoptosis of NSCs via alleviating telomere attrition in senescence-accelerated mouse prone 8 (SAMP8). In this study, 4-month-old male SAMP8 mice were assigned equal numbers to four different diet groups (n=15). Fifteen age-matched senescence-accelerated mouse resistant 1 (SAMR1) (Con-R) were used as the standard aging control group, feeding the FA-normal diet. After folic acid treatment 6-month, all mice were sacrificed. NSCs apoptosis, proliferation, oxidative damage and telomere length have been evaluated by immunofluorescence and Q-fluorescent in situ hybridization. The results showed that FA supplementation inhibited age-associated NSCs apoptosis and prevented telomere attrition in the cerebral cortex of SAMP8 mice. Importantly, this effect might be interpreted by the decreased levels of oxidative damage. In conclusion, we demonstrate it may be one of the mechanisms that FA inhibiting age-associated NSCs apoptosis by alleviating telomere length shortening. + + + + Li + Zhenshu + Z + + Tianjin Medical University, 12610, Department of Nutrition and Food Science, Tianjin, China; lizhenshu@tmu.edu.cn. + + + + Cai + Ke + K + + Tianjin Medical University General Hospital, 117865, Department of Cardiology, Tianjin, China; caikebaozi@163.com. + + + + Sun + Yue + Y + + Tianjin Medical University, 12610, Department of Nutrition and Food Science, Tianjin, China; sunyuejy163@163.com. + + + + Zhou + Dezheng + D + + Tianjin Medical University, 12610, Department of Nutrition and Food Science, Tianjin, China; dezhengzhou@163.com. + + + + Yan + Jing + J + + Tianjin Medical University, 12610, Department of Social Medicine and Health Administration, Tianjin, China; yanjing@tmu.edu.cn. + + + + Luo + Suhui + S + + Tianjin Medical University, 12610, Tianjin, China; suhui12345@126.com. + + + + Huang + Guowei + G + + Tianjin Medical University, 12610, School of Public Health, Tianjin, Tianjin, China; huangguowei@tmu.edu.cn. + + + + Gao + Yuxia + Y + + Tianjin Medical University General Hospital, 117865, Department of Cardiology, Tianjin, China; gaoyuxiatj@tmu.edu.cn. + + + + Li + Wen + W + + Tianjin Medical University, 12610, Department of Nutrition and Food Science, Tianjin, China. + + + Tianjin Key Laboratory of Environment Nutrition and Public Health, Tianjin, China; liwen828@tmu.edu.cn. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Canada + Appl Physiol Nutr Metab + 101264333 + 1715-5312 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 36 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809211 + 10.1139/apnm-2022-0111 + + +
+ + + 36809218 + + 2023 + 02 + 22 + +
+ + 1527-1315 + + + 2023 + Feb + 21 + + + Radiology + Radiology + + Free-breathing Arterial Spin Labeling MRI for the Detection of Pulmonary Embolism. + + 221998 + + 10.1148/radiol.221998 + + Background Arterial spin labeling (ASL) MRI can be used to assess organ perfusion but has yet to be implemented for perfusion evaluation of the lung. Purpose To evaluate pseudo-continuous ASL (PCASL) MRI for the detection of acute pulmonary embolism (PE) and its potential as an alternative to CT pulmonary angiography (CTPA). Materials and Methods Between November 2020 and November 2021, 97 patients (median age, 61 years; 48 women) with suspected PE were enrolled in this prospective study. PCASL MRI was performed within a 72-hour period following CTPA under free-breathing conditions and included three orthogonal planes. The pulmonary trunk was labeled during systole, and the image was acquired during diastole of the subsequent cardiac cycle. Additionally, multisection, coronal, balanced, steady-state free-precession imaging was carried out. Two radiologists blindly assessed overall image quality, artifacts, and diagnostic confidence (five-point Likert scale, 5 = best). Patients were categorized as positive or negative for PE, and a lobe-wise assessment in PCASL MRI and CTPA was conducted. Sensitivity and specificity were calculated on a patient level with the final clinical diagnosis serving as the reference standard. Interchangeability between MRI and CTPA was also tested with use of an individual equivalence index (IEI). Results PCASL MRI was performed successfully in all patients with high scores for image quality, artifact, and diagnostic confidence (κ ≥ .74). Of the 97 patients, 38 were positive for PE. PCASL MRI depicted PE correctly in 35 of 38 patients with three false-positive and three false-negative findings, resulting in a sensitivity of 35 of 38 patients (92% [95% CI: 79, 98]) and a specificity of 56 of 59 patients (95% [95% CI: 86, 99]). Interchangeability analysis revealed an IEI of 2.6% (95% CI: 1.2, 3.8). Conclusion Free-breathing pseudo-continuous arterial spin labeling MRI depicted abnormal lung perfusion caused by acute pulmonary embolism and may be useful as a contrast material-free alternative to CT pulmonary angiography for selected patients. German Clinical Trials Register no. DRKS00023599 © RSNA, 2023. + + + + Othman + Ahmed E + AE + 0000-0002-3827-8695 + + From the Department of Diagnostic and Interventional Radiology, University Department of Radiology (A.E.O., C.L., Y.K., M.M., M.K., B.G., K.N., T.K., F.S.), Department of Cardiology and Angiology (D.R.), Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, University Department of Radiology (M.S., P.M.), and Medical Image and Data Analysis (MIDAS.LAB), Department of Diagnostic and Interventional Radiology (T.K.), University Hospital Tübingen, Hoppe-Seyler-Str 3, 72076 Tübingen, Germany; Department of Neuroradiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany (A.E.O.); and High-Field MR Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany (R.P.). + + + + Liang + Cecilia + C + 0000-0002-6937-1681 + + From the Department of Diagnostic and Interventional Radiology, University Department of Radiology (A.E.O., C.L., Y.K., M.M., M.K., B.G., K.N., T.K., F.S.), Department of Cardiology and Angiology (D.R.), Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, University Department of Radiology (M.S., P.M.), and Medical Image and Data Analysis (MIDAS.LAB), Department of Diagnostic and Interventional Radiology (T.K.), University Hospital Tübingen, Hoppe-Seyler-Str 3, 72076 Tübingen, Germany; Department of Neuroradiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany (A.E.O.); and High-Field MR Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany (R.P.). + + + + Komma + Yasmin + Y + 0000-0002-4431-1973 + + From the Department of Diagnostic and Interventional Radiology, University Department of Radiology (A.E.O., C.L., Y.K., M.M., M.K., B.G., K.N., T.K., F.S.), Department of Cardiology and Angiology (D.R.), Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, University Department of Radiology (M.S., P.M.), and Medical Image and Data Analysis (MIDAS.LAB), Department of Diagnostic and Interventional Radiology (T.K.), University Hospital Tübingen, Hoppe-Seyler-Str 3, 72076 Tübingen, Germany; Department of Neuroradiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany (A.E.O.); and High-Field MR Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany (R.P.). + + + + Munz + Max + M + 0000-0001-6931-1489 + + From the Department of Diagnostic and Interventional Radiology, University Department of Radiology (A.E.O., C.L., Y.K., M.M., M.K., B.G., K.N., T.K., F.S.), Department of Cardiology and Angiology (D.R.), Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, University Department of Radiology (M.S., P.M.), and Medical Image and Data Analysis (MIDAS.LAB), Department of Diagnostic and Interventional Radiology (T.K.), University Hospital Tübingen, Hoppe-Seyler-Str 3, 72076 Tübingen, Germany; Department of Neuroradiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany (A.E.O.); and High-Field MR Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany (R.P.). + + + + Kolb + Manuel + M + + From the Department of Diagnostic and Interventional Radiology, University Department of Radiology (A.E.O., C.L., Y.K., M.M., M.K., B.G., K.N., T.K., F.S.), Department of Cardiology and Angiology (D.R.), Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, University Department of Radiology (M.S., P.M.), and Medical Image and Data Analysis (MIDAS.LAB), Department of Diagnostic and Interventional Radiology (T.K.), University Hospital Tübingen, Hoppe-Seyler-Str 3, 72076 Tübingen, Germany; Department of Neuroradiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany (A.E.O.); and High-Field MR Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany (R.P.). + + + + Rath + Dominik + D + + From the Department of Diagnostic and Interventional Radiology, University Department of Radiology (A.E.O., C.L., Y.K., M.M., M.K., B.G., K.N., T.K., F.S.), Department of Cardiology and Angiology (D.R.), Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, University Department of Radiology (M.S., P.M.), and Medical Image and Data Analysis (MIDAS.LAB), Department of Diagnostic and Interventional Radiology (T.K.), University Hospital Tübingen, Hoppe-Seyler-Str 3, 72076 Tübingen, Germany; Department of Neuroradiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany (A.E.O.); and High-Field MR Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany (R.P.). + + + + Gückel + Brigitte + B + + From the Department of Diagnostic and Interventional Radiology, University Department of Radiology (A.E.O., C.L., Y.K., M.M., M.K., B.G., K.N., T.K., F.S.), Department of Cardiology and Angiology (D.R.), Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, University Department of Radiology (M.S., P.M.), and Medical Image and Data Analysis (MIDAS.LAB), Department of Diagnostic and Interventional Radiology (T.K.), University Hospital Tübingen, Hoppe-Seyler-Str 3, 72076 Tübingen, Germany; Department of Neuroradiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany (A.E.O.); and High-Field MR Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany (R.P.). + + + + Pohmann + Rolf + R + 0000-0002-6137-9590 + + From the Department of Diagnostic and Interventional Radiology, University Department of Radiology (A.E.O., C.L., Y.K., M.M., M.K., B.G., K.N., T.K., F.S.), Department of Cardiology and Angiology (D.R.), Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, University Department of Radiology (M.S., P.M.), and Medical Image and Data Analysis (MIDAS.LAB), Department of Diagnostic and Interventional Radiology (T.K.), University Hospital Tübingen, Hoppe-Seyler-Str 3, 72076 Tübingen, Germany; Department of Neuroradiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany (A.E.O.); and High-Field MR Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany (R.P.). + + + + Nikolaou + Konstantin + K + 0000-0003-2668-7325 + + From the Department of Diagnostic and Interventional Radiology, University Department of Radiology (A.E.O., C.L., Y.K., M.M., M.K., B.G., K.N., T.K., F.S.), Department of Cardiology and Angiology (D.R.), Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, University Department of Radiology (M.S., P.M.), and Medical Image and Data Analysis (MIDAS.LAB), Department of Diagnostic and Interventional Radiology (T.K.), University Hospital Tübingen, Hoppe-Seyler-Str 3, 72076 Tübingen, Germany; Department of Neuroradiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany (A.E.O.); and High-Field MR Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany (R.P.). + + + + Schwartz + Martin + M + 0000-0002-9006-7844 + + From the Department of Diagnostic and Interventional Radiology, University Department of Radiology (A.E.O., C.L., Y.K., M.M., M.K., B.G., K.N., T.K., F.S.), Department of Cardiology and Angiology (D.R.), Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, University Department of Radiology (M.S., P.M.), and Medical Image and Data Analysis (MIDAS.LAB), Department of Diagnostic and Interventional Radiology (T.K.), University Hospital Tübingen, Hoppe-Seyler-Str 3, 72076 Tübingen, Germany; Department of Neuroradiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany (A.E.O.); and High-Field MR Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany (R.P.). + + + + Küstner + Thomas + T + 0000-0002-0353-4898 + + From the Department of Diagnostic and Interventional Radiology, University Department of Radiology (A.E.O., C.L., Y.K., M.M., M.K., B.G., K.N., T.K., F.S.), Department of Cardiology and Angiology (D.R.), Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, University Department of Radiology (M.S., P.M.), and Medical Image and Data Analysis (MIDAS.LAB), Department of Diagnostic and Interventional Radiology (T.K.), University Hospital Tübingen, Hoppe-Seyler-Str 3, 72076 Tübingen, Germany; Department of Neuroradiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany (A.E.O.); and High-Field MR Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany (R.P.). + + + + Martirosian + Petros + P + 0000-0001-8383-0883 + + From the Department of Diagnostic and Interventional Radiology, University Department of Radiology (A.E.O., C.L., Y.K., M.M., M.K., B.G., K.N., T.K., F.S.), Department of Cardiology and Angiology (D.R.), Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, University Department of Radiology (M.S., P.M.), and Medical Image and Data Analysis (MIDAS.LAB), Department of Diagnostic and Interventional Radiology (T.K.), University Hospital Tübingen, Hoppe-Seyler-Str 3, 72076 Tübingen, Germany; Department of Neuroradiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany (A.E.O.); and High-Field MR Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany (R.P.). + + + + Seith + Ferdinand + F + 0000-0002-9696-2954 + + From the Department of Diagnostic and Interventional Radiology, University Department of Radiology (A.E.O., C.L., Y.K., M.M., M.K., B.G., K.N., T.K., F.S.), Department of Cardiology and Angiology (D.R.), Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, University Department of Radiology (M.S., P.M.), and Medical Image and Data Analysis (MIDAS.LAB), Department of Diagnostic and Interventional Radiology (T.K.), University Hospital Tübingen, Hoppe-Seyler-Str 3, 72076 Tübingen, Germany; Department of Neuroradiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany (A.E.O.); and High-Field MR Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany (R.P.). + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Radiology + 0401260 + 0033-8419 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 36 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809218 + 10.1148/radiol.221998 + + +
+ + + 36809198 + + 2023 + 02 + 22 + +
+ + 1550-5065 + + 38 + 2 + + 2023 Apr-Jun 01 + + + Journal of nursing care quality + J Nurs Care Qual + + Hypoglycemia Management Using a Bundled Care Approach: A Quality Improvement Project. + + E32-E33 + + 10.1097/NCQ.0000000000000699 + eng + + Journal Article + +
+ + United States + J Nurs Care Qual + 9200672 + 1057-3631 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 36 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809198 + 10.1097/NCQ.0000000000000699 + 00001786-202304000-00019 + + +
+ + + 36809223 + + 2023 + 02 + 22 + +
+ + 1540-2010 + + + 2023 + Feb + 21 + + + Behavioral sleep medicine + Behav Sleep Med + + Sex as a moderator of the sleep and cognition relationship in middle-aged and older adults: A preliminary investigation. + + 1-14 + + 10.1080/15402002.2023.2177293 + + Despite known sex differences in the prevalence of sleep disturbance and cognitive impairment, research investigating sex differences in sleep/cognition associations is limited. We examined sex as a moderator of associations between self-reported sleep and objective cognition in middle-aged/older adults. + Adults aged 50+ (32 men/31 women, Mage = 63.6 ± 7.7) completed the Pittsburgh Sleep Quality Index (PSQI) and cognitive tasks: Stroop (processing speed, inhibition), Posner (spatial attentional orienting) and Sternberg (working memory). Multiple regressions examined whether PSQI metrics (global score, sleep quality ratings, sleep duration, sleep efficiency) were independently or interactively (with sex) associated with cognition, controlling for age and education. + Sex interacted with sleep quality ratings in its association with endogenous spatial attentional orienting (∆R2 = .10, p = .01). Worse ratings of sleep quality were associated with worse orienting in women (B = 22.73, SE = 9.53, p = .02), not men (p = .24). Sex interacted with sleep efficiency in its associations with processing speed (∆R2 = .06, p = .04). Lower sleep efficiency was associated with slower Stroop control trial performance in women (B = -15.91, SE = 7.57, p = .04), not men (p = .48). + Preliminary findings suggest middle-aged/older women are more vulnerable to associations between poor sleep quality and low sleep efficiency on spatial attentional orienting and processing speed, respectively. Future studies in larger samples investigating sex-specific prospective sleep and cognition associations are warranted. + + + + Curtis + Ashley F + AF + 0000-0002-2311-5674 + + College of Nursing, University of South Florida, Tampa, Florida, USA. + + + Department of Psychiatry, University of Missouri-Columbia, Columbia, Missouri, USA. + + + Department of Psychological Sciences, University of Missouri-Columbia, Columbia, Missouri, USA. + + + + Costa + Amy N + AN + + Department of Psychological Sciences, University of Missouri-Columbia, Columbia, Missouri, USA. + + + + Musich + Madison + M + + Department of Psychiatry, University of Missouri-Columbia, Columbia, Missouri, USA. + + + + Schmiedeler + Anthony + A + + Department of Psychiatry, University of Missouri-Columbia, Columbia, Missouri, USA. + + + Department of Educational, School, and Counseling Psychology, University of Missouri-Columbia, Columbia, Missouri, USA. + + + + Jagannathan + Sadhika + S + + Department of Behavioral Medicine and Psychiatry, West Virginia University. + + + + Connell + Maggie + M + + Department of Psychiatry, University of Missouri-Columbia, Columbia, Missouri, USA. + + + + Atkinson + Angela + A + + Department of Psychiatry, University of Missouri-Columbia, Columbia, Missouri, USA. + + + + Miller + Mary Beth + MB + + Department of Psychiatry, University of Missouri-Columbia, Columbia, Missouri, USA. + + + + McCrae + Christina S + CS + + College of Nursing, University of South Florida, Tampa, Florida, USA. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Behav Sleep Med + 101149327 + 1540-2002 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 36 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809223 + 10.1080/15402002.2023.2177293 + + +
+ + + 36809225 + + 2023 + 02 + 22 + +
+ + 1537-4513 + + + 2023 + Feb + 20 + + + Journal of immunotherapy (Hagerstown, Md. : 1997) + J Immunother + + A Novel Cell-based Luciferase Reporter Platform for the Development and Characterization of T-Cell Redirecting Therapies and Vaccine Development. + 10.1097/CJI.0000000000000453 + + T-cell immunotherapies are promising strategies to generate T-cell responses towards tumor-derived or pathogen-derived antigens. Adoptive transfer of T cells genetically modified to express antigen receptor transgenes has shown promise for the treatment of cancer. However, the development of T-cell redirecting therapies relies on the use of primary immune cells and is hampered by the lack of easy-to-use model systems and sensitive readouts to facilitate candidate screening and development. Particularly, testing T-cell receptor (TCR)-specific responses in primary T cells and immortalized T cells is confounded by the presence of endogenous TCR expression which results in mixed alpha/beta TCR pairings and compresses assay readouts. Herein, we describe the development of a novel cell-based TCR knockout (TCR-KO) reporter assay platform for the development and characterization of T-cell redirecting therapies. CRISPR/Cas9 was used to knockout the endogenous TCR chains in Jurkat cells stably expressing a human interleukin-2 promoter-driven luciferase reporter gene to measure TCR signaling. Reintroduction of a transgenic TCR into the TCR-KO reporter cells results in robust antigen-specific reporter activation compared with parental reporter cells. The further development of CD4/CD8 double-positive and double-negative versions enabled low-avidity and high-avidity TCR screening with or without major histocompatibility complex bias. Furthermore, stable TCR-expressing reporter cells generated from TCR-KO reporter cells exhibit sufficient sensitivity to probe in vitro T-cell immunogenicity of protein and nucleic acid-based vaccines. Therefore, our data demonstrated that TCR-KO reporter cells can be a useful tool for the discovery, characterization, and deployment of T-cell immunotherapy. + Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. + + + + Grailer + Jamison + J + + Department of Research, Promega Corporation, Madison, WI. + + + + Cheng + Zhijie Jey + ZJ + + + Hartnett + Jim + J + + + Slater + Michael + M + + + Fan + Frank + F + + + Cong + Mei + M + + + eng + + Journal Article + + + 2023 + 02 + 20 + +
+ + United States + J Immunother + 9706083 + 1524-9557 + + IM +
+ + + + 2022 + 07 + 15 + + + 2023 + 01 + 23 + + + 2023 + 2 + 22 + 13 + 36 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809225 + 10.1097/CJI.0000000000000453 + 00002371-990000000-00040 + + + + Kochenderfer JN, Rosenberg SA. Treating B-cell cancer with T cells expressing anti-CD19 chimeric antigen receptors. Rev Clin Oncol. 2013;10:267–276. + + + Schuster SJ, Bishop MR, Tam CS, et al. Tisagenlecleucel in adult relapsed or refractory diffuse large B-cell lymphoma. N Engl J Med. 2019;380:45–56. + + + Munshi NC, Anderson LD Jr, Shah N, et al. Idecabtagene vicleucel in relapsed and refractory multiple myeloma. N Engl J Med. 2021;384:705–716. + + + Call ME, Wucherpfenning KW. The T cell receptor: critical role of the membrane environment in receptor assembly and function. Annu Rev Immunol. 2005;23:101–125. + + + Harris DT, Kranz DM. Adoptive T cell therapies: a comparison of T cell receptors and chimeric antigen receptors. Trends Pharmacol Sci. 2016;37:220–230. + + + Jensen MC, Riddell SR. Designing chimeric antigen receptors to effectively and safely target tumors. Curr Opin Immunol. 2015;33:9–15. + + + Artyomov MN, Lis M, Devadas S, et al. CD4 and CD8 binding to MHC molecules primarily acts to enhance Lck delivery. Proc Natl Acad Sci USA. 2010;107:16916–16921. + + + Li QJ, Dinner AR, Qi S, et al. CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse. Nat Immunol. 2004;5:791–799. + + + Smith TW Jr, Nishimura MI. Targeting cancer with genetically engineered TCR T cells. Recent Results Cancer Res. 2020;214:129–151. + + + Liu Y, Yan X, Zhang F, et al. TCR-T immunotherapy: the challenges and solutions. Front Oncol. 2022;11:794183. + + + Hansen SG, Ford JC, Lewis MS, et al. Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine. Nature. 2011;473:523–527. + + + Swadling L, Capone S, Antrobus RD, et al. A human vaccine strategy based on chimpanzee adenoviral and MVA vectors that primes, boosts, and sustains functional HCV-specific T cell memory. Sci Transl Med. 2014;6:261ra153. + + + Panagioti E, Redeker A, van Duikeren S, et al. The breadth of synthetic long peptide vaccine-induced CD8+ T cell responses determines the efficacy against mouse cytomegalovirus infection. PLoS Pathog. 2016;12:e1005895. + + + Moss P. The T cell immune response against SARS-CoV-2. Nat Immunol. 2022;23:186–193. + + + McMahan K, Yu J, Mercado NB, et al. Correlates of protection against SARS-CoV-2 in rhesus macaques. Nature. 2021;590:630–634. + + + Sanyal G, Sarnefalt A, Kumar A. Considerations for bioanalytical characterization and batch release of COVID-19 vaccines. NPJ Vaccines. 2021;6:53. + + + Linnemann C, Heemskerk B, Kvistborg P, et al. High-throughput identification of antigen-specific TCRs by TCR gene capture. Nat Med. 2013;19:1534–1541. + + + Spindler MJ, Nelson AL, Wagner EK, et al. Massively parallel interrogation and mining of natively paired human TCRαβ repertoires. Nat Biotechnol. 2020;38:609–619. + + + Scheper W, Kelderman S, Fanchi LF, et al. Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers. Nat Med. 2019;25:89–94. + + + Abraham RT, Weiss A. Jurkat T cells and development of the T-cell receptor signalling paradigm. Nat Rev Immunol. 2004;4:301–308. + + + Muller TR, Schuler C, Hammel M, et al. A T-cell reporter platform for high-throughput and reliable investigation of TCR function and biology. Clin Transl Immunol. 2020;9:e1216. + + + Jutz S, Leitner J, Schmetterer K, et al. Assessment of costimulation and coinhibition in a triple parameter T cell reporter line: simultaneous measurement of NF-κB, NFAT and AP-1. J Immunol Methods. 2016;430:10–20. + + + Legut M, Dolton G, Mian AA, et al. CRISPR-mediated TCR replacement generates superior anticancer transgenic T cells. Blood. 2018;131:311–322. + + + Okamoto S, Mineno J, Ikeda H, et al. Improved expression and reactivity of transduced tumor-specific TCRs in human lymphocytes by specific silencing of endogenous TCR. Cancer Res. 2009;69:9003–9011. + + + Ahmadi M, King JW, Xue S-A, et al. CD3 limits the efficacy of TCR gene therapy in vivo. Blood. 2011;118:3528–3537. + + + van Loenen MM, de Boer R, Amir AL, et al. Mixed T cell receptor dimers harbor potentially harmful neoreactivity. Proc Natl Acad Sci USA. 2010;107:10972–10977. + + + Scholtalbers J, Boegel S, Bukur T, et al. TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression. Genome Med. 2015;7:118. + + + Hewitt CR, Lamb JR, Hayball J, et al. Major histocompatibility complex independent clonal T cell anergy by direct interaction of Staphylococcus aureus enterotoxin B with the T cell antigen receptor. J Exp Med. 1992;175:1493–1499. + + + Borbulevych OY, Santhanagopolan SM, Hossain M, et al. TCRs used in cancer gene therapy cross-react with MART-1/Melan-A tumor antigens via distinct mechanisms. J Immunol. 2011;187:2453–2463. + + + Johnson LA, Heemskerk B, Powell DJ Jr, et al. Gene transfer of tumor-reactive TCR confers both high avidity and tumor reactivity to nonreactive peripheral blood mononuclear cells and tumor-infiltrating lymphocytes. J Immunol. 2006;177:6548–6559. + + + Draper LM, Kwong MLM, Gros A, et al. Targeting of HPV-16+ epithelial cancer cells by TCR gene engineered T cells directed against E6. Clin Cancer Res. 2015;21:4431–4439. + + + Berges C, Naujokat C, Tinapp S, et al. A cell line model for the differentiation of human dendritic cells. Biochem Biophys Res Commun. 2005;333:896–907. + + + Hall MP, Unch J, Binkowski BF, et al. Engineered luciferase reporter from a deep sea shrimp utilizing a novel imidazopyrazinone substrate. ACS Chem Biol. 2012;7:1848–1857. + + + Hennecke J, Wiley DC. Structure of a complex of the human alpha/beta T cell receptor (TCR) HA1.7, influenza hemagglutinin peptide, and major histocompatibility complex class II molecule, HLA-DR4 (DRA-0101 and DRB1-0401): insight into TCR cross-restriction and alloreactivity. J Exp Med. 2002;195:571–581. + + + Hennecke J, Carfi A, Wiley DC. Structure of a covalently stabilized complex of a human alphabeta T-cell receptor, influenza HA peptide and MHC class II molecule, HLA-DR1. EMBO J. 2000;19:5611–5624. + + + Lamb JR, Eckels DD, Lake P, et al. Human T-cell clones recognize chemically synthesized peptides of influenza haemagglutinin. Nature. 1982;300:66–69. + + + Camp FA, Slansky JE. Implications of antigen selection on T cell-based immunotherapy. Pharmaceuticals (Basel). 2021;14:993. + + + Madura F, Rizkallah PJ, Legut M, et al. TCR-induced alteration of primary MHC peptide anchor residue. Eur J Immunol. 2019;49:1052–1066. + + + Borbulevych OY, Insaidoo FK, Baxter TK, et al. Structures of MART-126/27–35 peptide/HLA-A2 complex reveal a remarkable disconnect between antigen structural homology and T cell recognition. J Mol Biol. 2007;372:1123–1136. + + + Bravery CA, Carmen J, Fong T, et al. Potency assay development for cellular therapy products: an ISCT review of the requirements and experiences in the industry. Cytotherapy. 2013;15:9–19. + + + Schaft N, Lankiewicz B, Gratama JW, et al. Flexible and sensitive method to functionally validate tumor-specific receptors via activation of NFAT. J Immunol Methods. 2003;280:13–24. + + + Dykema AG, Zhang B, Woldemeskel BA, et al. Functional characterization of CD4+ T cell receptors crossreactive for SARS-CoV-2 and endemic coronaviruses. J Clin Invest. 2021;131:e146922. + + + En Tay R, Richardson EK, Chong Toh H. Revisiting the role of CD4+ T cells in cancer immunotherapy—new insights into old paradigms. Cancer Gene Ther. 2021;28:5–17. + + + Stone JD, Kranz DM. Role of T cell receptor affinity in the efficacy and specificity of adoptive T cell therapies. Front Immunol. 2013;4:244. + + + Li Y, Huo Y, Yu L, et al. Quality control and nonclinical research on CAR-T cell products: general principles and key issues. Engineering. 2019;5:122–131. + + + Lapazio L, Braun M, Grandien K. H2-M and H2-O as targeting vehicles for the MHC class II processing compartment promote antigen-specific CD4+ T cell activation. Vaccines (Basel). 2021;9:1053. + + + +
+ + + 36809227 + + 2023 + 02 + 22 + +
+ + 1530-0374 + + + 2023 + Feb + 21 + + + Menopause (New York, N.Y.) + Menopause + + Clinical considerations for menopause and associated symptoms in women with HIV: Released November 15, 2022. + 10.1097/GME.0000000000002146 + + Worldwide, more women with HIV are aging and entering menopause. Although a limited number of evidenced-based care recommendations are published, formal guidelines for the management of menopause in women with HIV are not available. Many women with HIV receive primary care from HIV infectious disease specialists, without any detailed assessment of menopause. Women's healthcare professionals specializing in menopause may have limited knowledge regarding the care of women with HIV. Clinical considerations for menopausal women with HIV include distinguishing menopause from amenorrhea because of other etiologies, early assessment of symptoms, and recognizing unique clinical, social, and behavioral comorbidities to facilitate care management. + Copyright © 2023 by The North American Menopause Society. + + + + Looby + Sara E + SE + + From Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Menopause + 9433353 + 1072-3714 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 36 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809227 + 10.1097/GME.0000000000002146 + 00042192-990000000-00158 + + + + UNAIDS. Global HIV & AIDS Statistics—Fact Sheet. 2021. www.unaids.org/en/resources/fact-sheet. Accessed August 30, 2022. + + + Centers for Disease Control and Prevention. Diagnosis of HIV infection in the United States and dependent areas, 2019. www.cdc.gov/hiv/library/reports/hiv-surveillance.html. May 2021. Accessed August 31, 2022. + + + Tariq S. British Medical Society Tools for Clinicians: HIV and the menopause. Post Reproductive Health 2019;25:38–39. doi: 10.1177/2053369119833884 + + 10.1177/2053369119833884 + + + + Cvetkovic A, King E, Skerritt L, et al. A practical clinical guide to counseling on and managing contraception, pre-conception planning, and menopause for women living with HIV. JAMMI 2021;6:278–295. doi: 10.3138/jammi-2021-0014 + + 10.3138/jammi-2021-0014 + + + + Andany N, Kaida A, de Pokomandy A, et al; CHIWOS Research Team. Prevalence and correlates of early-onset menopause among women living with HIV in Canada. Menopause 2020;27:66–75. doi: 10.1097/GME.0000000000001423 + + 10.1097/GME.0000000000001423 + + + + Looby SE, Shifren J, Corless I, et al. Increased hot flash severity and related interference in perimenopausal human immunodeficiency virus-infected women. Menopause 2014;21:403–409. doi: 10.1097/GME.0b013e31829d4c4c + + 10.1097/GME.0b013e31829d4c4c + + + + Rivard C, Philpotts LL, Flanagan J, Looby SE. Health characteristics associated with hot flashes in women with HIV during menopause: an integrative review. J Assoc Nurses AIDS Care 2019;30:87–97. doi: 10.1097/JNC.00000000000000248 + + 10.1097/JNC.00000000000000248 + + + + Solomon D, Sabin CA, Burns F, et al. The association between severe menopausal symptoms and engagement with HIV care and treatment in women living with HIV. AIDS Care 2021;33:101–108. doi: 10.1080/09540121.2020.1748559 + + 10.1080/09540121.2020.1748559 + + + + Schnall R, Jia H, Olender S, Gradilla M, Reame N. In people living with HIV (PLWH), menopause (natural or surgical) contributes to the greater symptom burden in women: results from an online US survey. Menopause 2018;25:744–752. doi: 10.1097/GME.0000000000001083 + + 10.1097/GME.0000000000001083 + + + + Alston C. Why all HIV care must be trauma-informed care. 2020. www.thebodypro.com/article/why-all-hiv-care-must-be-trauma-informed-care. Accessed August 29, 2022. + + + +
+ + + 36809226 + + 2023 + 02 + 22 + +
+ + 1091-6490 + + 120 + 8 + + 2023 + Feb + 21 + + + Proceedings of the National Academy of Sciences of the United States of America + Proc Natl Acad Sci U S A + + In This Issue. + + eiti0823120 + + 10.1073/iti0823120 + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Proc Natl Acad Sci U S A + 7505876 + 0027-8424 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 36 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809226 + 10.1073/iti0823120 + + +
+ + + 36809231 + + 2023 + 02 + 22 + +
+ + 1532-5040 + + + 2023 + Feb + 21 + + + Physiotherapy theory and practice + Physiother Theory Pract + + Online activity - A beaming good initiative! Delivering alternative exercise opportunities for people with cystic fibrosis. + + 1-7 + + 10.1080/09593985.2023.2182654 + + Increasing physical activity in people with Cystic Fibrosis (pwCF) can positively influence their physical and mental wellbeing. Online activities provide opportunity for outpatient CF populations to enhance physical activity. + PwCF within a large Scottish CF unit were invited to participate in a pilot study of online exercise and education sessions. Those participating shared opinions on motivation, fitness habits, types of activities enjoyed pre and during shielding, and desirable goals for online activity. Subsequently, an online activity timetable was created offering daily exercise classes. Educational presentations driven by patient request were delivered in context appropriate to health, wellbeing, and infection control needs during the pandemic and the advent of modulator therapies. Twenty-eight group exercise sessions and 12 educational sessions occurred over the six-week pilot, following which, a post-pilot questionnaire was sent to those who had participated in the sessions. Risk assessment and exercise modifications ensured safe practice and accommodation for all levels of respiratory disease. + Twenty-six pwCF attended one or more exercise sessions and 37 pwCF attended one or more education sessions. Group exercise and education improved time efficiency compared to in-person face-to-face delivery. The post-pilot questionnaire demonstrated increases in motivation and perceived fitness, with positive comments regarding peer support and enhanced socialization. Personal fitness goals were fully or partially achieved by 91% of participants. + Patient feedback suggested the implementation of online exercise and education sessions for pwCF was a satisfactory and convenient way to deliver exercise allowing for optimization and progression of personal goals. + + + + Morrison + L + L + + West of Scotland Adult CF Unit, Queen Elizabeth University Hospital, Glasgow, UK. + + + + McCrea + G + G + + West of Scotland Adult CF Unit, Queen Elizabeth University Hospital, Glasgow, UK. + + + + Palmer + S + S + + West of Scotland Adult CF Unit, Queen Elizabeth University Hospital, Glasgow, UK. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Physiother Theory Pract + 9015520 + 0959-3985 + + IM + + Cystic fibrosis + physical activity + telehealth + +
+ + + + 2023 + 2 + 22 + 13 + 37 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809231 + 10.1080/09593985.2023.2182654 + + +
+ + + 36809233 + + 2023 + 02 + 22 + +
+ + 2795-4552 + + + 2023 + Feb + 12 + + + ARP rheumatology + ARP Rheumatol + + Parameniscal cyst: an important differential diagnosis in slow growing masses of the knee. + + + + + Parameniscal cysts are small cystic lesions, near the meniscus, involving medial and lateral compartments at equal frequency. Frequently, parameniscal cysts are so small that patients do not notice them, being asymptomatic. However, they can grow and exceed 2 centimeters in diameter, causing pain and alarm due to the slow growing mass. Magnetic Resonance Imaging (MRI) is the gold standard for diagnosis. + Case report of a patient admitted to rheumatology department in the Centro Hospitalar e Universitário de Coimbra. + We report a case of a 47-year-old male with idiopathic juvenile arthritis, who presented with a slow-growing mass over the medial aspect of the right knee. MRI revealed a conspicuous cystic ovoid lesion, compatible with a parameniscal cyst, associated with structural heterogeneity of the posterior edge of the internal meniscus with a longitudinal fracture at this level. + This is the first case of parameniscal cyst reported in patients with inflammatory rheumatic disease and the differential diagnosis with synovial cyst, baker cyst, ganglion cyst, bursitis, hematoma and neoplasms is of utmost importance. + + + + Saraiva + Liliana + L + + Centro Hospitalar e Universitário de Coimbra. + + + + Saraiva + André Pinto + AP + + Centro Hospitalar e Universitário de Coimbra. + + + + Coutinho + Margarida + M + + Centro Hospitalar e Universitário de Coimbra. + + + + Pereira da Silva + José António + JA + + Centro Hospitalar e Universitário de Coimbra. + + + + eng + + Journal Article + + Parameniscal cyst: an important differential diagnosis in slow growing masses of the knee. + + 2023 + 02 + 12 + +
+ + Portugal + ARP Rheumatol + 9918402287906676 + 2795-4552 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 37 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809233 + IR220296 + + +
+ + + 36809234 + + 2023 + 02 + 22 + +
+ + 2164-554X + + + 2023 + Feb + 21 + + + Human vaccines & immunotherapeutics + Hum Vaccin Immunother + + Biomarkers for predicting tumor response to PD-1 inhibitors in patients with advanced pancreatic cancer. + + 2178791 + + 10.1080/21645515.2023.2178791 + + Pancreatic cancer is among the most lethal malignant neoplasms, and few patients with pancreatic cancer benefit from immunotherapy. We retrospectively analyzed advanced pancreatic cancer patients who received PD-1 inhibitor-based combination therapies during 2019-2021 in our institution. The clinical characteristics and peripheral blood inflammatory markers (neutrophil-to-lymphocyte ratio [NLR], platelet-to-lymphocyte ratio [PLR], lymphocyte-to-monocyte ratio [LMR], and lactate dehydrogenase [LDH]) were collected at baseline. Chi-squared and Fisher's exact tests were used to evaluate relationships between the above parameters and tumor response. Cox regression analyses were employed to assess the effects of baseline factors on patients' survival and immune-related adverse events (irAEs). Overall, 67 patients who received at least two cycles of PD-1 inhibitor were considered evaluable. A lower NLR was independent predictor for objective response rate (38.1% vs. 15.2%, P = .037) and disease control rate (81.0% vs. 52.2%, P = .032). In our study population, patients with lower LDH had superior progression-free survival (PFS) and overall survival(OS) (mPFS, 5.4 vs. 2.8 months, P < .001; mOS, 13.3 vs. 3.6 months, P < .001). Liver metastasis was verified to be a negative prognostic factor for PFS (2.4 vs. 7.8 months, P < .001) and OS (5.7 vs. 18.0 months, P < .001). The most common irAEs were hypothyroidism (13.4%) and rash (10.5%). Our study demonstrated that the pretreatment inflammatory markers were independent predictors for tumor response, and the baseline LDH level and liver metastasis were potential prognostic markers of survival in patients with pancreatic cancer treated with PD-1 inhibitors. + + + + Qiu + Xin + X + + The Comprehensive Cancer Center of Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing, China. + + + The Comprehensive Cancer Center of Drum Tower Hospital, Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China. + + + + Shi + Zhan + Z + + The Comprehensive Cancer Center of Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing, China. + + + + Tong + Fan + F + + The Comprehensive Cancer Center of Drum Tower Hospital, Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China. + + + + Lu + Changchang + C + + The Comprehensive Cancer Center of Drum Tower Hospital, Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China. + + + + Zhu + Yahui + Y + + The Comprehensive Cancer Center of Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing, China. + + + + Wang + Qiaoli + Q + + The Comprehensive Cancer Center of Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing, China. + + + + Gu + Qing + Q + + National Institute of Healthcare Data Science, Nanjing University, Nanjing, China. + + + + Qian + Xiaoping + X + + The Comprehensive Cancer Center of Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing, China. + + + + Meng + Fanyan + F + + The Comprehensive Cancer Center of Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing, China. + + + + Liu + Baorui + B + + The Comprehensive Cancer Center of Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing, China. + + + + Du + Juan + J + + The Comprehensive Cancer Center of Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing, China. + + + The Comprehensive Cancer Center of Drum Tower Hospital, Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Hum Vaccin Immunother + 101572652 + 2164-5515 + + IM + + PD-1 inhibitors + Pancreatic cancer + biomarkers + inflammatory markers + liver metastasis + +
+ + + + 2023 + 2 + 22 + 13 + 37 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809234 + 10.1080/21645515.2023.2178791 + + +
+ + + 36809224 + + 2023 + 02 + 22 + +
+ + 1437-4315 + + + 2023 + Feb + 23 + + + Biological chemistry + Biol Chem + + The second PI(3,5)P2 binding site in the S0 helix of KCNQ1 stabilizes PIP2-at the primary PI1 site with potential consequences on intermediate-to-open state transition. + 10.1515/hsz-2022-0247 + + The Phosphatidylinositol 3-phosphate 5-kinase Type III PIKfyve is the main source for selectively generated phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2), a known regulator of membrane protein trafficking. PI(3,5)P2 facilitates the cardiac KCNQ1/KCNE1 channel plasma membrane abundance and therewith increases the macroscopic current amplitude. Functional-physical interaction of PI(3,5)P2 with membrane proteins and its structural impact is not sufficiently understood. This study aimed to identify molecular interaction sites and stimulatory mechanisms of the KCNQ1/KCNE1 channel via the PIKfyve-PI(3,5)P2 axis. Mutational scanning at the intracellular membrane leaflet and nuclear magnetic resonance (NMR) spectroscopy identified two PI(3,5)P2 binding sites, the known PIP2 site PS1 and the newly identified N-terminal α-helix S0 as relevant for functional PIKfyve effects. Cd2+ coordination to engineered cysteines and molecular modeling suggest that repositioning of S0 stabilizes the channel s open state, an effect strictly dependent on parallel binding of PI(3,5)P2 to both sites. + © 2022 Walter de Gruyter GmbH, Berlin/Boston. + + + + Dellin + Maurice + M + + IfGH-Cellular Electrophysiology, Department of Cardiology and Angiology, University Hospital of Münster, Robert-Koch Str. 45, D-48149, Münster, Germany. + + + + Rohrbeck + Ina + I + + IfGH-Cellular Electrophysiology, Department of Cardiology and Angiology, University Hospital of Münster, Robert-Koch Str. 45, D-48149, Münster, Germany. + + + + Asrani + Purva + P + + Faculty of Chemistry and Biochemistry, Biomolecular NMR Spectroscopy and RUBiospek|NMR, Ruhr University of Bochum, Universitätsstraße 150, D-44780, Bochum, Germany. + + + + Schreiber + Julian A + JA + + IfGH-Cellular Electrophysiology, Department of Cardiology and Angiology, University Hospital of Münster, Robert-Koch Str. 45, D-48149, Münster, Germany. + + + Institut für Pharmazeutische und Medizinische Chemie, Westfälische Wilhelms-Universität Münster, Corrensstraße 48, D-48149, Münster, Germany. + + + + Ritter + Nadine + N + + IfGH-Cellular Electrophysiology, Department of Cardiology and Angiology, University Hospital of Münster, Robert-Koch Str. 45, D-48149, Münster, Germany. + + + GRK 2515, Chemical biology of ion channels (Chembion), Westfälische Wilhelms-Universität Münster, Münster, Germany. + + + + Glorius + Frank + F + + GRK 2515, Chemical biology of ion channels (Chembion), Westfälische Wilhelms-Universität Münster, Münster, Germany. + + + Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, D-48149, Münster, Germany. + + + + Wünsch + Bernhard + B + https://orcid.org/0000-0002-9030-8417 + + Institut für Pharmazeutische und Medizinische Chemie, Westfälische Wilhelms-Universität Münster, Corrensstraße 48, D-48149, Münster, Germany. + + + GRK 2515, Chemical biology of ion channels (Chembion), Westfälische Wilhelms-Universität Münster, Münster, Germany. + + + + Budde + Thomas + T + https://orcid.org/0000-0002-5263-8183 + + GRK 2515, Chemical biology of ion channels (Chembion), Westfälische Wilhelms-Universität Münster, Münster, Germany. + + + Institute of Physiology I, Westfälische Wilhelms-Universität, Robert-Koch-Str. 27a, D-48149, Münster, Germany. + + + + Temme + Louisa + L + + Institut für Pharmazeutische und Medizinische Chemie, Westfälische Wilhelms-Universität Münster, Corrensstraße 48, D-48149, Münster, Germany. + + + GRK 2515, Chemical biology of ion channels (Chembion), Westfälische Wilhelms-Universität Münster, Münster, Germany. + + + + Strünker + Timo + T + https://orcid.org/0000-0003-0812-1547 + + GRK 2515, Chemical biology of ion channels (Chembion), Westfälische Wilhelms-Universität Münster, Münster, Germany. + + + Centre of Reproductive Medicine and Andrology, University Hospital Münster, University of Münster, Domagkstraße 11, D-48149, Münster, Germany. + + + Cells in Motion Interfaculty Centre, University of Münster, Münster, Germany. + + + + Stallmeyer + Birgit + B + + Institute of Reproductive Genetics, University of Münster, Vesaliusweg 12-14, D-48149, Münster, Germany. + + + + Tüttelmann + Frank + F + https://orcid.org/0000-0003-2745-9965 + + Institute of Reproductive Genetics, University of Münster, Vesaliusweg 12-14, D-48149, Münster, Germany. + + + + Meuth + Sven G + SG + + Department of Neurology, Heinrich Heine University Düsseldorf, Moorenstraße 5, D-40225, Düsseldorf, Germany. + + + + Spehr + Marc + M + + Department of Chemosensation, Institute for Biology II, RWTH Aachen University, Worringerweg 3, D-52074, Aachen, Germany. + + + + Matschke + Johann + J + https://orcid.org/0000-0003-4878-8741 + + Institute of Cell Biology (Cancer Research), University Hospital Essen, University of Duisburg-Essen, D-45147, Essen, Germany. + + + + Steinbicker + Andrea + A + + Goethe University Frankfurt and University Hospital Frankfurt, Theodor-Stern-Kai 7, D-60590, Frankfurt, Germany. + + + + Gatsogiannis + Christos + C + https://orcid.org/0000-0002-4922-4545 + + Institute for Medical Physics and Biophysics and Center for Soft Nanoscience, Westfälische Wilhelms-Universität Münster, Münster, Busso-Peus Strasse 10, D-48149, Germany. + + + + Stoll + Raphael + R + https://orcid.org/0000-0003-2890-8419 + + Faculty of Chemistry and Biochemistry, Biomolecular NMR Spectroscopy and RUBiospek|NMR, Ruhr University of Bochum, Universitätsstraße 150, D-44780, Bochum, Germany. + + + + Strutz-Seebohm + Nathalie + N + + IfGH-Cellular Electrophysiology, Department of Cardiology and Angiology, University Hospital of Münster, Robert-Koch Str. 45, D-48149, Münster, Germany. + + + + Seebohm + Guiscard + G + + IfGH-Cellular Electrophysiology, Department of Cardiology and Angiology, University Hospital of Münster, Robert-Koch Str. 45, D-48149, Münster, Germany. + + + GRK 2515, Chemical biology of ion channels (Chembion), Westfälische Wilhelms-Universität Münster, Münster, Germany. + + + + eng + + Journal Article + + + 2023 + 02 + 23 + +
+ + Germany + Biol Chem + 9700112 + 1431-6730 + + IM + + electrophysiology + molecular modeling + phosphatidylinositol + phosphoinositides + phospholipid + potassium channels + +
+ + + + 2022 + 08 + 05 + + + 2022 + 12 + 13 + + + 2023 + 2 + 22 + 13 + 36 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809224 + hsz-2022-0247 + 10.1515/hsz-2022-0247 + + + + de Araujo, M.E.G., Liebscher, G., Hess, M.W., and Huber, L.A. (2020). Lysosomal size matters. Traffic 21: 60–75, https://doi.org/10.1111/tra.12714 . + + 10.1111/tra.12714 + + + + Bargal, R., Avidan, N., Ben-Asher, E., Olender, Z., Zeigler, M., Frumkin, A., Raas-Rothschild, A., Glusman, G., Lancet, D., and Bach, G. (2000). Identification of the gene causing mucolipidosis type IV. Nat. Genet. 26: 118–123, https://doi.org/10.1038/79095 . + + 10.1038/79095 + + + + Barhanin, J., Lesage, F., Guillemare, E., Fink, M., Lazdunski, M., and Romey, G. (1996). K(v)LQT1 and IsK (minK) proteins associate to form the I-Ks cardiac potassium current. Nature 384: 78–80, https://doi.org/10.1038/384078a0 . + + 10.1038/384078a0 + + + + Berridge, M.J. (1984). Inositol trisphosphate and diacylglycerol as second messengers. Biochem. J. 220: 345–360, https://doi.org/10.1042/bj2200345 . + + 10.1042/bj2200345 + + + + Chen, K.E., Healy, M.D., and Collins, B.M. (2019). Towards a molecular understanding of endosomal trafficking by Retromer and Retriever. Traffic 20: 465–478, https://doi.org/10.1111/tra.12649 . + + 10.1111/tra.12649 + + + + Cheng, W.W.L., Arcario, M.J., Petroff, J.T. (2021). Druggable lipid binding sites in pentameric ligand-gated ion channels and transient receptor potential channels. Front. Physiol. 12: 798102, https://doi.org/10.3389/fphys.2021.798102 . + + 10.3389/fphys.2021.798102 + + + + Cullen, P.J. and Steinberg, F. (2018). To degrade or not to degrade: mechanisms and significance of endocytic recycling. Nat. Rev. Mol. Cell Biol. 19: 679–696, https://doi.org/10.1038/s41580-018-0053-7 . + + 10.1038/s41580-018-0053-7 + + + + De Craene, J.O., Bertazzi, D.L., Bar, S., and Friant, S. (2017). Phosphoinositides, major actors in membrane trafficking and lipid signaling pathways. Int. J. Mol. Sci. 18: 634, https://doi.org/10.3390/ijms18030634 . + + 10.3390/ijms18030634 + + + + Delmas, P. and Brown, D.A. (2005). Pathways modulating neural KCNQ/M (Kv7) potassium channels. Nat. Rev. Neurosci. 6: 850–862, https://doi.org/10.1038/nrn1785 . + + 10.1038/nrn1785 + + + + Dickson, E.J. and Hille, B. (2019). Understanding phosphoinositides: rare, dynamic, and essential membrane phospholipids. Biochem. J. 476: 1–23, https://doi.org/10.1042/bcj20180022 . + + 10.1042/bcj20180022 + + + + Dove, S.K., Dong, K., Kobayashi, T., Williams, F.K., and Michell, R.H. (2009). Phosphatidylinositol 3, 5-bisphosphate and Fab1p/PIKfyve underPPIn endo-lysosome function. Biochem. J. 419: 1–13, https://doi.org/10.1042/bj20081950 . + + 10.1042/bj20081950 + + + + Eckey, K., Wrobel, E., Strutz-Seebohm, N., Pott, L., Schmitt, N., and Seebohm, G. (2014). 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Pflüger’s Arch 437: 172–174, https://doi.org/10.1007/s004240050765 . + + 10.1007/s004240050765 + + + + Rink, J., Ghigo, E., Kalaidzidis, Y., and Zerial, M. (2005). Rab conversion as a mechanism of progression from early to late endosomes. Cell 122: 735–749, https://doi.org/10.1016/j.cell.2005.06.043 . + + 10.1016/j.cell.2005.06.043 + + + + Royal, A.A., Tinker, A., and Harmer, S.C. (2017). Phosphatidylinositol-4, 5-bisphosphate is required for KCNQ1/KCNE1 channel function but not anterograde trafficking. PLoS One 12: e0186293, https://doi.org/10.1371/journal.pone.0186293 . + + 10.1371/journal.pone.0186293 + + + + Rutherford, A.C., Traer, C., Wassmer, T., Pattni, K., Bujny, M.V., Carlton, J.G., Stenmark, H., and Cullen, P.J. (2006). The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport. 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A study of interaction of cadmium(II) ions with cysteine. Listy Cukrov. a Reparske 126: 422. + + + Zolov, S.N., Bridges, D., Zhang, Y., Lee, W.W., Riehle, E., Verma, R., Lenk, G.M., Converso-Baran, K., Weide, T., Albin, R.L., et al.. (2012). In vivo, Pikfyve generates PI(3, 5)P2, which serves as both a signaling lipid and the major precursor for PI5P. Proc. Natl. Acad. Sci. U.S.A. 109: 17472–17477, https://doi.org/10.1073/pnas.1203106109 . + + 10.1073/pnas.1203106109 + + + + +
+ + + 36809228 + + 2023 + 02 + 22 + +
+ + 2162-2973 + + + 2023 + Feb + 21 + + + Applied neuropsychology. Child + Appl Neuropsychol Child + + Prospective evaluation of 24-hour movement behaviors among adolescents recovering from a sport-related concussion. + + 1-9 + + 10.1080/21622965.2023.2181082 + + This study aimed to describe the 24-hour composition of movement behaviors, including sleep, sedentary behavior, and physical activity (PA), among pediatric sports-related concussion (SRC) patients over their recovery period, assess the association between movement compositions and recovery time, and understand feasibility of 24-hour accelerometry in the study population. A cohort of 50 pediatric SRC patients were asked to wear a wrist-worn accelerometer continuously for the duration of their recovery. Among all enrolled participants, the sample was primarily 14 or 15 years of age (65%), female (55%), and recovered in under 28 days (88%). Accelerometer compliance was moderate; 35 participants (70%) were compliant with the protocol. Compositional analysis was used to address time-use objectives in 33 participants who provided adequate data for inclusion. Overall, participants spent an average of 50% of their 24-hour day sedentary, 33% sleeping, 11% in light intensity PA, and 6% in moderate or vigorous intensity PA. The 24-hour composition of movement behaviors was not associated with recovery time (p = .09-.99). However, the limited sample size may have contributed to null findings. Given recent evidence supporting the effects of sedentary behavior and PA on concussion recovery, future studies should aim to further validate these findings in a larger sample. + + + + Brayton + Riley P + RP + 0000-0003-3458-2750 + + Research Staff, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston (UTHealth), Dallas, Texas, USA. + + + + Price + August M + AM + + Concussion Program Director, Sports Neuropsychology, Bellapianta Orthopaedics and Sports Medicine, Montclair, New Jersey, USA. + + + + Jones + Carrie + C + + Certified Athletic Trainer, Sport Neuropsychology, Children's Health Andrews Institute for Orthopedics and Sports Medicine, Plano, Texas, USA. + + + + Ellis + Christine + C + + Pediatric Nurse Practitioner, Sport Neuropsychology, Children's Health Andrews Institute for Orthopedics and Sports Medicine, Plano, Texas, USA. + + + + Burkhart + Scott + S + + Senior Program Director, Sport Neuropsychology, Children's Health Andrews Institute for Orthopedics and Sports Medicine, Plano, TX, USA. + + + + Knell + Gregory + G + + Assistant Professor, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston (UTHealth), Dallas, Texas, USA. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Appl Neuropsychol Child + 101584990 + 2162-2965 + + IM + + Concussion + compositional analysis + movement behavior + time-use + +
+ + + + 2023 + 2 + 22 + 13 + 36 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809228 + 10.1080/21622965.2023.2181082 + + +
+ + + 36809229 + + 2023 + 02 + 22 + +
+ + 1464-5033 + + + 2023 + Feb + 21 + + + Annals of human biology + Ann Hum Biol + + The genetic structure and admixture of Manchus and Koreans in northeast China. + + 1-26 + + 10.1080/03014460.2023.2182912 + + The fine-scale genetic profiles and population history of Manchus and Koreans remain unclear. + To infer a fine-scale genetic structure and admixture of Manchu and Korean populations. + We collected and genotyped 16 Manchus from Liaoning and 18 Koreans from Jilin province with about 700K genome-wide SNPs. We analysed the data using principal component analysis (PCA), ADMIXTURE, Fst, TreeMix, f-statistics, qpWave, and qpAdm. + Manchus and Koreans showed a genetic affinity with northern East Asians. Chinese Koreans showed a long-term genetic continuity with Bronze Age populations from the West Liao River and had a strong affinity with Koreans in South Korea and Japan. Manchus had a different genetic profile compared with other Tungusic populations since the Manchus received additional genetic influence from the southern Chinese but didn't have West Eurasian-related admixture. + The genetic formation of Manchus involving southern Chinese was consistent with the extensive interactions between Manchus and populations from central and southern China. The large-scale genetic continuity between ancient West Liao River farmers and Koreans highlighted the role farming expansion played in the peopling of the Korean Peninsula. + + + + Sun + Na + N + + College of Foreign Languages, Huaqiao University, 362021, Quanzhou, China. + + + + Tao + Le + L + + State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen 361102, China. + + + + Wang + Rui + R + + State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen 361102, China. + + + + Zhu + Kongyang + K + + State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen 361102, China. + + + + Hai + Xiangjun + X + + Key Laboratory of Environmental Ecology and Population Health in Northwest Minority Areas, Northwest Minzu University, Lanzhou, China. + + + + Wang + Chuan-Chao + CC + + State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen 361102, China. + + + Department of Anthropology and Ethnology, Institute of Anthropology, School of Sociology and Anthropology, Xiamen University 361005, Xiamen, China. + + + State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen 361102, China. + + + Institute of Artificial Intelligence, Xiamen University, Xiamen 361005, China. + + + Ministry of Education Key Laboratory of Contemporary Anthropology, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Ann Hum Biol + 0404024 + 0301-4460 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 36 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809229 + 10.1080/03014460.2023.2182912 + + +
+ + + 36809238 + + 2023 + 02 + 22 + +
+ + 1366-5928 + + + 2023 + Feb + 21 + + + Xenobiotica; the fate of foreign compounds in biological systems + Xenobiotica + + The Metabolism of the Dual Orexin Receptor Antagonist Daridorexant. + + 1-37 + + 10.1080/00498254.2023.2183159 + + Daridorexant is a dual orexin receptor antagonist developed for the treatment of insomnia disorder and has shown improvement in sleep outcomes and daytime functioning. The present work describes its biotransformation pathways in vitro and in vivo and provides a cross-species comparison between the animal species used in preclinical safety assessments and man.Daridorexant clearance is driven by metabolism along seven distinct pathways. Metabolic profiles were characterized by downstream products while primary metabolic products were of minor importance. The metabolic pattern differed between rodent species, with the rat reflecting the human pattern better than the mouse.In rodents, daridorexant is mostly excreted via the bile after extensive metabolism while urinary excretion was negligible in the rat. Only traces of parent drug were detected in urine, bile or faeces.Daridorexant has three major metabolites which are well covered in these preclinical safety species. All of them retain some residual affinity towards orexin receptors. However, none of these is considered to contribute to the pharmacological effect of daridorexant as their active concentrations in human brain are too low. + + + + Treiber + Alexander + A + + Department of Non-clinical Pharmacokinetics and Metabolism and. + + + + Delahaye + Stephane + S + + Department of Non-clinical Pharmacokinetics and Metabolism and. + + + + Weigel + Aude + A + + Department of Non-clinical Pharmacokinetics and Metabolism and. + + + + Aeänismaa + Päivi + P + + Department of Non-clinical Pharmacokinetics and Metabolism and. + + + + Gatfield + John + J + + Department of Biology, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland. + + + + Seeland + Swen + S + + Department of Non-clinical Pharmacokinetics and Metabolism and. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Xenobiotica + 1306665 + 0049-8254 + + IM + + Insomnia + clearance + daridorexant + excretion + human + metabolism + metabolite + mouse + orexin + rat + +
+ + + + 2023 + 2 + 22 + 13 + 37 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809238 + 10.1080/00498254.2023.2183159 + + +
+ + + 36809249 + + 2023 + 02 + 22 + +
+ + 1935-2735 + + 17 + 2 + + 2023 + Feb + 21 + + + PLoS neglected tropical diseases + PLoS Negl Trop Dis + + Data-driven predictions of potential Leishmania vectors in the Americas. + + e0010749 + + 10.1371/journal.pntd.0010749 + + The incidence of vector-borne diseases is rising as deforestation, climate change, and globalization bring humans in contact with arthropods that can transmit pathogens. In particular, incidence of American Cutaneous Leishmaniasis (ACL), a disease caused by parasites transmitted by sandflies, is increasing as previously intact habitats are cleared for agriculture and urban areas, potentially bringing people into contact with vectors and reservoir hosts. Previous evidence has identified dozens of sandfly species that have been infected with and/or transmit Leishmania parasites. However, there is an incomplete understanding of which sandfly species transmit the parasite, complicating efforts to limit disease spread. Here, we apply machine learning models (boosted regression trees) to leverage biological and geographical traits of known sandfly vectors to predict potential vectors. Additionally, we generate trait profiles of confirmed vectors and identify important factors in transmission. Our model performed well with an average out of sample accuracy of 86%. The models predict that synanthropic sandflies living in areas with greater canopy height, less human modification, and within an optimal range of rainfall are more likely to be Leishmania vectors. We also observed that generalist sandflies that are able to inhabit many different ecoregions are more likely to transmit the parasites. Our results suggest that Psychodopygus amazonensis and Nyssomia antunesi are unidentified potential vectors, and should be the focus of sampling and research efforts. Overall, we found that our machine learning approach provides valuable information for Leishmania surveillance and management in an otherwise complex and data sparse system. + Copyright: © 2023 Vadmal et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Vadmal + Gowri M + GM + https://orcid.org/0000-0002-2549-8496 + + Department of Biology, Stanford University, Stanford, California, United States of America. + + + + Glidden + Caroline K + CK + + Department of Biology, Stanford University, Stanford, California, United States of America. + + + + Han + Barbara A + BA + + Cary Institute of Ecosystem Studies, Millbrook, New York, United States of America. + + + + Carvalho + Bruno M + BM + + Climate and Health Program, Barcelona Institute for Global Health, Barcelona, Spain. + + + + Castellanos + Adrian A + AA + + Cary Institute of Ecosystem Studies, Millbrook, New York, United States of America. + + + + Mordecai + Erin A + EA + + Department of Biology, Stanford University, Stanford, California, United States of America. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS Negl Trop Dis + 101291488 + 1935-2727 + + IM + The authors declare that they have no conflict of interest. +
+ + + + 2022 + 08 + 17 + + + 2023 + 01 + 24 + + + 2023 + 2 + 22 + 13 + 38 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809249 + 10.1371/journal.pntd.0010749 + PNTD-D-22-01062 + + +
+ + + 36809246 + + 2023 + 02 + 22 + +
+ + 1532-5040 + + + 2023 + Feb + 21 + + + Physiotherapy theory and practice + Physiother Theory Pract + + Perceived preparedness and training needs of new graduate physiotherapists' working with First Nations Australians. + + 1-14 + + 10.1080/09593985.2023.2179382 + + There is a considerable and ongoing health gap experienced by First Nations Australians. Physiotherapists play an integral role in the health care of this population; however, little is known about new graduate preparedness and training needs to work in a First Nations context. + To explore the perceptions of new graduate physiotherapists regarding their preparedness and training needs for working with First Nation Australians. + Qualitative telephone, semi-structured interviews of new graduate physiotherapists (n = 13) who have worked with First Nations Australians in the last two years. Inductive, reflexive thematic analysis was used. + Five themes were generated: 1) limitations of pre-professional training; 2) benefits of work integrated learning; 3) 'on the job' development; 4) intrapersonal factors and efforts; and 5) insights into improving training. + New graduate physiotherapists perceive that their preparedness to work in a First Nations health context is supported by practical and varied learning experiences. At the pre-professional level, new graduates benefit from work integrated learning and opportunities that evoke critical self-reflection. At the professional level, new graduates express a need for 'on the job' development, peer supervision, and tailored professional development, that focuses on the unique perspectives of the specific community in which they work. + + + + Nelson + Curtley + C + 0000-0002-3475-3209 + + School of Health and Rehabilitation Sciences, University of Queensland, St Lucia, Australia. + + + + Mandrusiak + Allison + A + 0000-0003-4180-9167 + + School of Health and Rehabilitation Sciences, University of Queensland, St Lucia, Australia. + + + + Forbes + Roma + R + 0000-0002-9959-3875 + + School of Health and Rehabilitation Sciences, University of Queensland, St Lucia, Australia. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Physiother Theory Pract + 9015520 + 0959-3985 + + IM + + First Nations Australians + First Nations Peoples + curriculum + indigenous + physiotherapy + qualitative + training + +
+ + + + 2023 + 2 + 22 + 13 + 37 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809246 + 10.1080/09593985.2023.2179382 + + +
+ + + 36809236 + + 2023 + 02 + 22 + +
+ + 1654-9880 + + 16 + 1 + + 2023 + Dec + 31 + + + Global health action + Glob Health Action + + Maintaining HIV testing and treatment services in Zambia during COVID-19: a story of success and resilience. + + 2175992 + + 10.1080/16549716.2023.2175992 + + Coronavirus disease 2019 (COVID-19) is caused by a virus called severe acute respiratory syndrome coronavirus. As countries struggled to control the spread of the virus through among other measures closure of health facilities, repurposing of health care workers, and restrictions on people's movement, HIV service delivery was affected. + To assess the impact of COVID-19 on HIV service delivery in Zambia by comparing uptake of HIV services before and during COVID-19. + We used repeated cross-sectional quarterly and monthly data on HIV testing, HIV positivity rate, people living with HIV initiating ART and use of essential hospital services from July 2018 to December 2020. We assessed quarterly trends and measured proportionate changes comparing periods before and during COVID-19 divided into three different comparison time frames: (1) annual comparison 2019 versus 2020; (2) April to December 2019 versus same period in 2020; and (3) Quarter 1 of 2020 as base period versus each of the other quarters of year 2020. + Annual HIV testing dropped by 43.7% (95%CI 43.6-43.7) in 2020 compared to 2019 and was similar by sex. Overall, annual recorded number of newly diagnosed PLHIV fell by 26.5% (95% CI 26.37-26.73) in 2020 compared to 2019, but HIV positivity rate was higher in 2020, 6.44% (95%CI 6.41-6.47) compared to 4.94% (95% CI 4.92-4.96) in 2019. Annual ART initiation dropped by 19.9% (95%CI 19.7-20.0) in 2020 compared to 2019 while use of essential hospital services dropped during the early months of COVID-19 April to August 2020 but picked up later in the year. + While COVID-19 had a negative impact on health service delivery, its impact on HIV service delivery was not huge. HIV policies that were implemented before COVID-19 on testing made it easier to adopt COVID-19 control measures and to continue providing HIV testing services without much disruption. + + + + Chisenga + Tina + T + + Ministry of Health Zambia, Department of Communicable Diseases, Lusaka, Zambia. + + + + Chihana + Menard + M + 0000-0003-2616-9894 + + World Health Organization, Global HIV, Hepatitis and STI Programmes, Geneva, Switzerland. + + + + Chishimba + Paul + P + + Ministry of Health Zambia, Department of Monitoring and Evaluation, Lusaka, Zambia. + + + + Chitembo + Lastone + L + + World Health Organization, Department of HIV, Viral Hepatitis and STIs, Lusaka, Zambia. + + + + Mulenga + Lloyd + L + + Department of Infectious Disease, University Teaching Hospital, Lusaka, Zambia. + + + + Silumesii + Andrew + A + + Ministry of Health Zambia, Department of Monitoring and Evaluation, Lusaka, Zambia. + + + + Maman + David + D + + World Health Organization, Global HIV, Hepatitis and STI Programmes, Geneva, Switzerland. + + + The Global Fund, Technical Advice and Partnership Department, Geneva, Switzerland. + + + + Johnson + Cheryl + C + 0000-0001-5499-5523 + + World Health Organization, Global HIV, Hepatitis and STI Programmes, Geneva, Switzerland. + + + + eng + + Journal Article + +
+ + United States + Glob Health Action + 101496665 + 1654-9880 + + IM + + ART + Covid-19 + HIV + HIV testing services + health service delivery + +
+ + + + 2023 + 2 + 22 + 13 + 37 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809236 + 10.1080/16549716.2023.2175992 + + +
+ + + 36809242 + + 2023 + 02 + 22 + +
+ + 1744-5213 + + + 2023 + Feb + 21 + + + Journal of the history of the neurosciences + J Hist Neurosci + + Illustrating insanity: Allan McLane Hamilton, Types of Insanity, and physiognomy in late nineteenth-century American medicine. + + 1-31 + + 10.1080/0964704X.2022.2162343 + + This article examines the divisive reception history of American psychiatrist and neurologist Alexander McLane Hamilton's physiognomy publication, Types of Insanity (1883). By analyzing 23 book reviews published in late-nineteenth-century medical journals, the authors present a bibliographic case study that traces the mixed professional reactions to Hamilton's work, thus revealing the fraught nature of physiognomy in the American medical community. In effect, the authors argue that the interprofessional disagreements that emerged among journal reviewers indicate the nascent efforts of psychiatrists and neurologists to oppose physiognomy in the interest of professionalization. By extension, the authors emphasize the historical value of book reviews and reception literature. Often overlooked as ephemera, book reviews register the shifting ideologies, temperaments, and attitudes of an era's readership. + + + + Galbo + Sebastian C + SC + 0000-0003-0321-2976 + + Abbott Library, Robert L. Brown History of Medicine Collection, Buffalo, New York, USA. + + + Department of English, University at Buffalo, Buffalo, New York, USA. + + + + Mages + Keith C + KC + 0000-0003-2102-1858 + + Abbott Library, Robert L. Brown History of Medicine Collection, Buffalo, New York, USA. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + J Hist Neurosci + 9441330 + 0964-704X + + IM + + Book reviews + United States + brain + diagnosis + facial expression + facies + mentally ill persons + mind + nineteenth century + phrenology + physiognomy + professionalization + psychiatry + visual culture + +
+ + + + 2023 + 2 + 22 + 13 + 37 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809242 + 10.1080/0964704X.2022.2162343 + + +
+ + + 36809252 + + 2023 + 02 + 22 + +
+ + 1932-6203 + + 18 + 2 + + 2023 + + + PloS one + PLoS One + + Prevalence and determinants of neonatal near miss in Ethiopia: A systematic review and meta-analysis. + + e0278741 + + 10.1371/journal.pone.0278741 + + Neonatal near miss is a condition of newborn infant characterized by severe morbidity (near miss), but survived these conditions within the first 27 days of life. It is considered as the first step to design management strategies that can contribute in reducing long term complication and mortality. The aim of this study was to assess prevalence and determinants of neonatal near miss in Ethiopia. + The protocol of this systematic review and meta-analysis was registered at the Prospero with a registration number of (PROSPERO 2020: CRD42020206235). International online databases such as PubMed, CINAHL, Google scholar, Global Health, Directory of open Access journal and African Index Medicus were used to search articles. Data extraction was undertaken with Microsoft Excel and STATA11 was used to conduct the Meta-Analysis. Random effect model analysis was considered when there was evidence of heterogeneity between the studies. + The overall pooled prevalence of neonatal near miss was 35.51% (95%CI: 20.32-50.70, I2 = 97.0%, p = 0.000). Primiparity (OR = 2.52, 95%CI: 1.62, 3.42), referral linkage (OR = 3.92, 95%CI: 2.73, 5.12), premature rupture of membrane (OR = 5.05, 95%CI: 2.03, 8.08), Obstructed labor (OR = 4.27, 95%CI: 1.62, 6.91) and maternal medical complications during pregnancy (OR = 7.10, 95%CI: 1.23, 12.98) had shown significant statistical association with neonatal near miss. + The prevalence of neonatal near miss in Ethiopia is evidenced to be high. Primiparity, referral linkage, premature rupture of membrane, obstructed labor and maternal medical complications during pregnancy were found to be determinant factors of neonatal near miss. + Copyright: © 2023 Deressa, Desta. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Deressa + Ababe Tamirat + AT + https://orcid.org/0000-0002-7016-2860 + + School of Nursing, Saint Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia. + + + + Desta + Melese Siyoum + MS + https://orcid.org/0000-0001-5451-5665 + + Department of Midwifery, College of Medicine and Health Sciences, Hawassa University, Hawassa, Ethiopia. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2020 + 10 + 20 + + + 2022 + 11 + 22 + + + 2023 + 2 + 22 + 13 + 38 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809252 + 10.1371/journal.pone.0278741 + PONE-D-20-32942 + + +
+ + + 36809235 + + 2023 + 02 + 22 + +
+ + 1553-7358 + + 19 + 2 + + 2023 + Feb + 21 + + + PLoS computational biology + PLoS Comput Biol + + Resonant learning in scale-free networks. + + e1010894 + + 10.1371/journal.pcbi.1010894 + + Large networks of interconnected components, such as genes or machines, can coordinate complex behavioral dynamics. One outstanding question has been to identify the design principles that allow such networks to learn new behaviors. Here, we use Boolean networks as prototypes to demonstrate how periodic activation of network hubs provides a network-level advantage in evolutionary learning. Surprisingly, we find that a network can simultaneously learn distinct target functions upon distinct hub oscillations. We term this emergent property resonant learning, as the new selected dynamical behaviors depend on the choice of the period of the hub oscillations. Furthermore, this procedure accelerates the learning of new behaviors by an order of magnitude faster than without oscillations. While it is well-established that modular network architecture can be selected through evolutionary learning to produce different network behaviors, forced hub oscillations emerge as an alternative evolutionary learning strategy for which network modularity is not necessarily required. + Copyright: © 2023 Goldman et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Goldman + Samuel + S + https://orcid.org/0000-0002-3928-6873 + + Department of Molecular and Cellular Biology, Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, United States of America. + + + + Aldana + Maximino + M + + Instituto de Ciencias Fisicas, Universidad Nacional Autónoma de México, Cuernavaca, Mexico. + + + Centro de Ciencias de la Complejidad, Universidad Nacional Autónoma de México, Coyoacán, Mexico City, Mexico. + + + + Cluzel + Philippe + P + https://orcid.org/0000-0001-8545-1879 + + Department of Molecular and Cellular Biology, Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, United States of America. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS Comput Biol + 101238922 + 1553-734X + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 07 + 13 + + + 2023 + 01 + 24 + + + 2023 + 2 + 22 + 13 + 37 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809235 + 10.1371/journal.pcbi.1010894 + PCOMPBIOL-D-22-01074 + + +
+ + + 36809230 + + 2023 + 02 + 22 + +
+ + 1092-874X + + + 2023 + Feb + 21 + + + International journal of toxicology + Int J Toxicol + + Safety Assessment of Apple-Derived Ingredients as Used in Cosmetics. + + 10915818231156873 + + 10.1177/10915818231156873 + + The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of 26 apple-derived ingredients, which reportedly function mostly as skin conditioning agents in cosmetic products. Because apple-derived ingredients may be obtained from different apple cultivars, the composition of ingredients derived from different cultivars should be similar to that of ingredients reviewed in this safety assessment. Additionally, industry should continue to use good manufacturing practices to limit impurities that could be present in botanical ingredients. The Panel reviewed the available data to determine the safety of these ingredients and concluded that 21 of these ingredients are safe in cosmetics in the present practices of use and concentrations described in this safety assessment. However, the Panel also determined that the available data are insufficient to determine the safety of Pyrus Malus (Apple) Root Extract, Pyrus Malus (or Malus Domestica) (Apple) Stem Extract, Malus Domestica (Apple) Callus Extract, and Malus Domestica (Apple) Oil. + + + + Johnson + Wilbur + W + + Cosmetic Ingredient Review Former Senior Scientific Analyst/Writer. + + + + Bergfeld + Wilma F + WF + + Expert Panel for Cosmetic Ingredient Safety Member. + + + + Belsito + Donald V + DV + + Expert Panel for Cosmetic Ingredient Safety Member. + + + + Hill + Ronald A + RA + + Expert Panel for Cosmetic Ingredient Safety Former Member. + + + + Klaassen + Curtis D + CD + + Expert Panel for Cosmetic Ingredient Safety Member. + + + + Liebler + Daniel C + DC + + Expert Panel for Cosmetic Ingredient Safety Former Member. + + + + Marks + James G + JG + + Expert Panel for Cosmetic Ingredient Safety Former Member. + + + + Shank + Ronald C + RC + + Expert Panel for Cosmetic Ingredient Safety Former Member. + + + + Slaga + Thomas J + TJ + + Expert Panel for Cosmetic Ingredient Safety Member. + + + + Snyder + Paul W + PW + + Expert Panel for Cosmetic Ingredient Safety Member. + + + + Gill + Lillian J + LJ + + Cosmetic Ingredient Review Former Director. + + + + Heldreth + Bart + B + + Cosmetic Ingredient Review Executive Director. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Int J Toxicol + 9708436 + 1091-5818 + + IM + + Pyrus Malus + apple + cosmetics + safety + +
+ + + + 2023 + 2 + 22 + 13 + 36 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809230 + 10.1177/10915818231156873 + + +
+ + + 36809245 + + 2023 + 02 + 22 + +
+ + 1553-7404 + + 19 + 2 + + 2023 + Feb + 21 + + + PLoS genetics + PLoS Genet + + GRAS-1 is a novel regulator of early meiotic chromosome dynamics in C. elegans. + + e1010666 + + 10.1371/journal.pgen.1010666 + + Chromosome movements and licensing of synapsis must be tightly regulated during early meiosis to ensure accurate chromosome segregation and avoid aneuploidy, although how these steps are coordinated is not fully understood. Here we show that GRAS-1, the worm homolog of mammalian GRASP/Tamalin and CYTIP, coordinates early meiotic events with cytoskeletal forces outside the nucleus. GRAS-1 localizes close to the nuclear envelope (NE) in early prophase I and interacts with NE and cytoskeleton proteins. Delayed homologous chromosome pairing, synaptonemal complex (SC) assembly, and DNA double-strand break repair progression are partially rescued by the expression of human CYTIP in gras-1 mutants, supporting functional conservation. However, Tamalin, Cytip double knockout mice do not exhibit obvious fertility or meiotic defects, suggesting evolutionary differences between mammals. gras-1 mutants show accelerated chromosome movement during early prophase I, implicating GRAS-1 in regulating chromosome dynamics. GRAS-1-mediated regulation of chromosome movement is DHC-1-dependent, placing it acting within the LINC-controlled pathway, and depends on GRAS-1 phosphorylation at a C-terminal S/T cluster. We propose that GRAS-1 coordinates the early steps of homology search and licensing of SC assembly by regulating the pace of chromosome movement in early prophase I. + Copyright: © 2023 Martinez-Garcia et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Martinez-Garcia + Marina + M + https://orcid.org/0000-0001-8491-2557 + + Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, United States of America. + + + + Naharro + Pedro Robles + PR + + Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, United States of America. + + + + Skinner + Marnie W + MW + https://orcid.org/0000-0003-2928-7693 + + Biochemistry and Molecular Biology Department, John Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland, United States of America. + + + Department of Biochemistry and Molecular Biology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America. + + + + Baran + Kerstin A + KA + + Biochemistry and Molecular Biology Department, John Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland, United States of America. + + + + Lascarez-Lagunas + Laura I + LI + + Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, United States of America. + + + + Nadarajan + Saravanapriah + S + https://orcid.org/0000-0001-5273-4514 + + Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, United States of America. + + + + Shin + Nara + N + https://orcid.org/0000-0002-9910-4971 + + Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, United States of America. + + + + Silva-García + Carlos G + CG + https://orcid.org/0000-0002-0434-7787 + + Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Harvard University, Boston, Massachusetts, United States of America. + + + + Saito + Takamune T + TT + + Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, United States of America. + + + + Beese-Sims + Sara + S + + Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, United States of America. + + + + Diaz-Pacheco + Brianna N + BN + https://orcid.org/0000-0001-9014-1234 + + Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, United States of America. + + + + Berson + Elizaveta + E + + Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, United States of America. + + + + Castañer + Ana B + AB + + Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, United States of America. + + + + Pacheco + Sarai + S + https://orcid.org/0000-0002-3425-4901 + + MRC London Institute of Medical Sciences, London, United Kingdom. + + + + Martinez-Perez + Enrique + E + + MRC London Institute of Medical Sciences, London, United Kingdom. + + + + Jordan + Philip W + PW + https://orcid.org/0000-0003-4890-2647 + + Biochemistry and Molecular Biology Department, John Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland, United States of America. + + + Department of Biochemistry and Molecular Biology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America. + + + + Colaiácovo + Monica P + MP + https://orcid.org/0000-0001-7803-4372 + + Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, United States of America. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS Genet + 101239074 + 1553-7390 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 10 + 27 + + + 2023 + 02 + 13 + + + 2023 + 2 + 22 + 13 + 37 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809245 + 10.1371/journal.pgen.1010666 + PGENETICS-D-22-01241 + + +
+ + + 36809232 + + 2023 + 02 + 22 + +
+ + 1465-3966 + + + 2023 + Feb + 21 + + + Psychology, health & medicine + Psychol Health Med + + Tracking COVID-19 vaccination expectancies and vaccination refusal in the United States. + + 1-20 + + 10.1080/13548506.2023.2181977 + + To identify factors that predict COVID-19 vaccination refusal and show how expectancies affect vaccination acceptance for non-vaccinated adults, we used a monthly repeated cross-sectional sample from June/2021 to October/2021 to collect data on vaccination behaviors and predictor variables for 2,116 US adults over 50 years of age. Selection bias modeling - which is required when data availability is a result of behavioral choice - predicts two outcomes: (1) no vaccination vs. vaccination for the entire sample and (2) the effects of expectancy indices predicting vaccination Refuser vs. vaccination Accepters for the unvaccinated group. Vaccine refusers were younger and less educated, endorsed common misconceptions about the COVID-19 epidemic, and were Black. Vaccination expectancies were related to vaccination refusal in the unvaccinated eligible group: negative expectancies increased vaccine refusal, while positive expectancies decreased it. We conclude that behavior-related expectancies (as opposed to more stable psychological traits) are important to identify because they are often modifiable and provide a point of intervention, not just for COVID-19 vaccination acceptance but also for other positive health behaviors. + + + + Hennessy + Michael + M + + Department of Communication, University of Delaware, Newark, DE, United States. + + + + Bleakley + Amy + A + + Department of Communication, University of Delaware, Newark, DE, United States. + + + + Langbaum + Jessica B + JB + + Banner Alzheimer's Institute, Phoenix, AZ, United States. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Psychol Health Med + 9604099 + 1354-8506 + + IM + + COVID-19 vaccination intention + Expectancy value + vaccine refusers + +
+ + + + 2023 + 2 + 22 + 13 + 37 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809232 + 10.1080/13548506.2023.2181977 + + +
+ + + 36809244 + + 2023 + 02 + 22 + +
+ + 1521-057X + + + 2023 + Feb + 21 + + + The Journal of legal medicine + J Leg Med + + Editor's Note. + + 1 + + 10.1080/01947648.2023.2179848 + + + Piorkowski + Joseph D + JD + Jr + + + eng + + Editorial + + + 2023 + 02 + 21 + +
+ + United States + J Leg Med + 8000151 + 0194-7648 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 37 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809244 + 10.1080/01947648.2023.2179848 + + +
+ + + 36809253 + + 2023 + 02 + 22 + +
+ + 1969-6213 + + + 2023 + Feb + 17 + + + EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology + EuroIntervention + + Reproducibility of bolus versus continuous thermodilution for assessment of coronary microvascular function in patients with ANOCA. + EIJ-D-22-00772 + 10.4244/EIJ-D-22-00772 + + A bolus thermodilution-derived index of microcirculatory resistance (IMR) has emerged as the standard for assessing coronary microvascular dysfunction (CMD). Continuous thermodilution has recently been introduced as a tool to quantify absolute coronary flow and microvascular resistance directly. Microvascular resistance reserve (MRR) derived from continuous thermodilution has been proposed as a novel metric of microvascular function, which is independent of epicardial stenoses and myocardial mass. + We aimed to assess the reproducibility of bolus and continuous thermodilution in assessing coronary microvascular function. + Patients with angina and non-obstructive coronary artery disease (ANOCA) at angiography were prospectively enrolled. Bolus and continuous intracoronary thermodilution measurements were obtained in duplicate in the left anterior descending artery (LAD). Patients were randomly assigned in a 1:1 ratio to undergo either bolus thermodilution first or continuous thermodilution first. + A total of 102 patients were enrolled. The mean fractional flow reserve (FFR) was 0.86±0.06. Coronary flow reserve (CFR) calculated with continuous thermodilution (CFRcont) was significantly lower than bolus thermodilution-derived CFR (CFRbolus; 2.63±0.65 vs 3.29±1.17; p<0.001). CFRcont showed a higher reproducibility than CFRbolus (variability: 12.7±10.4% continuous vs 31.26±24.85% bolus; p<0.001). MRR showed a higher reproducibility than IMR (variability 12.4±10.1% continuous vs 24.2±19.3% bolus; p<0.001). No correlation was found between MRR and IMR (r=0.1, 95% confidence interval: -0.09 to 0.29; p=0.305). + In the assessment of coronary microvascular function, continuous thermodilution demonstrated significantly less variability on repeated measurements than bolus thermodilution. + + + + Gallinoro + Emanuele + E + + Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium. + + + Department of Translational Medical Sciences, University of Campania 'Luigi Vanvitelli', Naples, Italy. + + + + Bertolone + Dario Tino + DT + + Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium. + + + Department of Advanced Biomedical Sciences, University Federico II, Naples, Italy. + + + + Fernandez-Peregrina + Estefania + E + + Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium. + + + + Paolisso + Pasquale + P + + Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium. + + + Department of Advanced Biomedical Sciences, University Federico II, Naples, Italy. + + + + Bermpeis + Konstantinos + K + + Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium. + + + + Esposito + Giuseppe + G + + Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium. + + + Department of Advanced Biomedical Sciences, University Federico II, Naples, Italy. + + + + Gomez-Lopez + Andrea + A + + Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium. + + + + Candreva + Alessandro + A + + Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium. + + + Department of Cardiology, Zurich University Hospital, Zurich, Switzerland. + + + Department of Mechanical and Aerospace Engineering, PolitoBIO Med Lab, Politecnico di Torino, Italy. + + + + Mileva + Niya + N + + Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium. + + + + Belmonte + Marta + M + + Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium. + + + + Mizukami + Takuya + T + + Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium. + + + + Fournier + Stephane + S + + Department of Cardiology, Lausanne University Hospital, Lausanne, Switzerland. + + + + Vanderheyden + Marc + M + + Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium. + + + + Wyffels + Eric + E + + Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium. + + + + Bartunek + Jozef + J + + Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium. + + + + Sonck + Jeroen + J + + Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium. + + + + Barbato + Emanuele + E + + Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium. + + + Department of Advanced Biomedical Sciences, University Federico II, Naples, Italy. + + + + Collet + Carlos + C + + Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium. + + + + De Bruyne + Bernard + B + + Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium. + + + Department of Cardiology, Lausanne University Hospital, Lausanne, Switzerland. + + + + eng + + Journal Article + + + 2023 + 02 + 17 + +
+ + France + EuroIntervention + 101251040 + 1774-024X + + IM +
+ + + + 2023 + 2 + 22 + 13 + 38 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809253 + EIJ-D-22-00772 + 10.4244/EIJ-D-22-00772 + + +
+ + + 36809239 + + 2023 + 02 + 22 + +
+ + 1553-7358 + + 19 + 2 + + 2023 + Feb + 21 + + + PLoS computational biology + PLoS Comput Biol + + Phenotypic pliancy and the breakdown of epigenetic polycomb mechanisms. + + e1010889 + + 10.1371/journal.pcbi.1010889 + + Epigenetic regulatory mechanisms allow multicellular organisms to develop distinct specialized cell identities despite having the same total genome. Cell-fate choices are based on gene expression programs and environmental cues that cells experience during embryonic development, and are usually maintained throughout the life of the organism despite new environmental cues. The evolutionarily conserved Polycomb group (PcG) proteins form Polycomb Repressive Complexes that help orchestrate these developmental choices. Post-development, these complexes actively maintain the resulting cell fate, even in the face of environmental perturbations. Given the crucial role of these polycomb mechanisms in providing phenotypic fidelity (i.e. maintenance of cell fate), we hypothesize that their dysregulation after development will lead to decreased phenotypic fidelity allowing dysregulated cells to sustainably switch their phenotype in response to environmental changes. We call this abnormal phenotypic switching phenotypic pliancy. We introduce a general computational evolutionary model that allows us to test our systems-level phenotypic pliancy hypothesis in-silico and in a context-independent manner. We find that 1) phenotypic fidelity is an emergent systems-level property of PcG-like mechanism evolution, and 2) phenotypic pliancy is an emergent systems-level property resulting from this mechanism's dysregulation. Since there is evidence that metastatic cells behave in a phenotypically pliant manner, we hypothesize that progression to metastasis is driven by the emergence of phenotypic pliancy in cancer cells as a result of PcG mechanism dysregulation. We corroborate our hypothesis using single-cell RNA-sequencing data from metastatic cancers. We find that metastatic cancer cells are phenotypically pliant in the same manner as predicted by our model. + Copyright: © 2023 Lambros et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Lambros + Maryl + M + https://orcid.org/0000-0002-8434-2459 + + Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, New York, United States of America. + + + + Sella + Yehonatan + Y + + Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, New York, United States of America. + + + + Bergman + Aviv + A + https://orcid.org/0000-0002-6340-2125 + + Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, New York, United States of America. + + + Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, United States of America. + + + Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, United States of America. + + + Santa Fe Institute, Santa Fe, New Mexico, United States of America. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS Comput Biol + 101238922 + 1553-734X + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 03 + 29 + + + 2023 + 01 + 23 + + + 2023 + 2 + 22 + 13 + 37 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809239 + 10.1371/journal.pcbi.1010889 + PCOMPBIOL-D-22-00497 + + +
+ + + 36809240 + + 2023 + 02 + 22 + +
+ + 1744-5078 + + + 2023 + Feb + 21 + + + Ocular immunology and inflammation + Ocul Immunol Inflamm + + A Thematic Analysis of Online Uveitis Support Groups. + + 1-6 + + 10.1080/09273948.2023.2178937 + + To report the availability and activity of online uveitis support groups. + An online search was conducted for support groups for uveitis. Member count and activity were recorded. Posts and comments were graded along five themes: emotional or personal story sharing, information seeking, offer of outside information, emotional support, and expressions of gratitude. + An online search resulted in 32 support groups for uveitis. Across all groups, there was a median membership of 725 (IQR 1410.5). Of the 32 groups, five were active and accessible at the time of study. In these five groups, 337 posts and 1406 comments were made within the past year. The most prevalent theme in posts consisted of information seeking (84%) while the most prevalent theme in comments consisted of emotion or personal story sharing (65%). + Online uveitis support groups provide a unique space for emotional support, information sharing, and community building.Abbreviations: OIUF - Ocular Inflammation and Uveitis Foundation. + + + + Rasheed + Haroon Adam + HA + 0000-0003-4544-2497 + + David Geffen School of Medicine at UCLA, Los Angeles, California, USA. + + + + Rasheed + Yusuf Salman + YS + + Yale University, New Haven, Connecticut, USA. + + + + Syed-Quadri + Shafee + S + + University of California, Davis, California, USA. + + + + Tsui + Edmund + E + 0000-0001-7532-9191 + + Ocular Inflammatory Disease Center, UCLA Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, California, USA. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Ocul Immunol Inflamm + 9312169 + 0927-3948 + + IM + + Education + social media + support group + uveitis + +
+ + + + 2023 + 2 + 22 + 13 + 37 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809240 + 10.1080/09273948.2023.2178937 + + +
+ + + 36809255 + + 2023 + 02 + 22 + +
+ + 1935-2735 + + 17 + 2 + + 2023 + Feb + 21 + + + PLoS neglected tropical diseases + PLoS Negl Trop Dis + + Borrelia miyamotoi a neglected tick-borne relapsing fever spirochete in Thailand. + + e0011159 + + 10.1371/journal.pntd.0011159 + + Borrelia miyamotoi is a relapsing fever spirochete that shares the same vector [fas Lyme disease causing Borrelia. This epidemiological study of B. miyamotoi was conducted in rodent reservoirs, tick vectors and human populations simultaneously. A total of 640 rodents and 43 ticks were collected from Phop Phra district, Tak province, Thailand. The prevalence rate for all Borrelia species was 2.3% and for B. miyamotoi was 1.1% in the rodent population, while the prevalence rate was quite high in ticks collected from rodents with an infection rate of 14.5% (95% CI: 6.3-27.6%). Borrelia miyamotoi was detected in Ixodes granulatus collected from Mus caroli and Berylmys bowersi, and was also detected in several rodent species (Bandicota indica, Mus spp., and Leopoldamys sabanus) that live in a cultivated land, increasing the risk of human exposure. Phylogenetic analysis revealed that the B. miyamotoi isolates detected in rodents and I. granulatus ticks in this study were similar to isolates detected in European countries. Further investigation was conducted to determine the serological reactivity to B. miyamotoi in human samples received from Phop Phra hospital, Tak province and in rodents captured from Phop Phra district using an in-house, direct enzyme-linked immunosorbent assay (ELISA) assay with B. miyamotoi recombinant glycerophosphodiester-phosphodiesterase (rGlpQ) protein as coated antigen. The results showed that 17.9% (15/84) of human patients and 9.0% (41/456) of captured rodents had serological reactivity to B. miyamotoi rGlpQ protein in the study area. While a low level of IgG antibody titers (100-200) was observed in the majority of seroreactive samples, higher titers (400-1,600) were also detected in both humans and rodents. This study provides the first evidence of B. miyamotoi exposure in human and rodent populations in Thailand and the possible roles of local rodent species and Ixodes granulatus tick in its enzootic transmission cycle in nature. + Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. + + + + Takhampunya + Ratree + R + https://orcid.org/0000-0001-5136-3547 + + Department of Entomology, United States Army Medical Directorate-Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand. + + + + Longkunan + Asma + A + + Department of Entomology, United States Army Medical Directorate-Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand. + + + + Somchaimongkol + Sakbuncha + S + + Phop Phra Hospital, 245 Moo 2 Phop Phra District, Tak Province, Thailand. + + + + Youngdech + Nittayaphon + N + + Department of Entomology, United States Army Medical Directorate-Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand. + + + + Chanarat + Nitima + N + + Department of Entomology, United States Army Medical Directorate-Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand. + + + + Sakolvaree + Jira + J + + Department of Entomology, United States Army Medical Directorate-Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand. + + + + Tippayachai + Bousaraporn + B + + Department of Entomology, United States Army Medical Directorate-Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand. + + + + Promsathaporn + Sommai + S + + Department of Entomology, United States Army Medical Directorate-Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand. + + + + Phanpheuch + Bhakdee + B + + Phop Phra Hospital, 245 Moo 2 Phop Phra District, Tak Province, Thailand. + + + + Poole-Smith + Betty K + BK + + Department of Entomology, United States Army Medical Directorate-Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand. + + + + McCardle + Patrick W + PW + + Department of Entomology, United States Army Medical Directorate-Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand. + + + + Lindroth + Erica J + EJ + + Department of Entomology, United States Army Medical Directorate-Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS Negl Trop Dis + 101291488 + 1935-2727 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 09 + 04 + + + 2023 + 02 + 10 + + + 2023 + 2 + 22 + 13 + 38 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809255 + 10.1371/journal.pntd.0011159 + PNTD-D-22-01143 + + +
+ + + 36809250 + + 2023 + 02 + 22 + +
+ + 2191-0308 + + + 2023 + Feb + 22 + + + Reviews on environmental health + Rev Environ Health + + Monkeypox and drug repurposing: seven potential antivirals to combat the viral disease. + 10.1515/reveh-2023-0001 + + The growing concern about the monkeypox (Mpox) virus infection has garnered a lot of public attention. However, the treatment options available to combat the same is limited to tecovirimat. Additionally, in a possible incidence of resistance, hypersensitivity, or adverse drug reaction, it is imperative to devise and reinforce the second-line therapy. Thus, in this editorial, the authors suggest seven antiviral drugs that could potentially be repurposed to combat the viral illness. + © 2023 Walter de Gruyter GmbH, Berlin/Boston. + + + + Varghese + Ryan + R + https://orcid.org/0000-0001-6817-2261 + + Poona College of Pharmacy, Bharati Vidyapeeth (Deemed to be) University, Pune Maharashtra, India. + + + Department of Clinical Pharmacology, Advanced Centre for Treatment, Research, and Education in Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai, India. + + + + Patel + Pal + P + https://orcid.org/0000-0001-8891-6352 + + Department of Genetic Engineering, College of Engineering and Technology, SRM Institute of Science and Technology, Kattankalathur, Tamil Nadu, India. + + + + Kumar + Dileep + D + https://orcid.org/0000-0002-3418-4325 + + Poona College of Pharmacy, Bharati Vidyapeeth (Deemed to be) University, Pune Maharashtra, India. + + + Department of Entomology, University of California, Davis, CA, USA. + + + UC Davis Comprehensive Cancer Center, University of California, Davis, CA, USA. + + + + Sharma + Rohit + R + https://orcid.org/0000-0002-3682-3573 + + Department of Rasa Shastra and Bhaishajya Kalpana, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India. + + + + eng + + Letter + + + 2023 + 02 + 22 + +
+ + Germany + Rev Environ Health + 0425754 + 0048-7554 + + IM + + antivirals + brincidofovir + drug repurposing + monkey pox + mpox + orthopoxviruses + pharmaceuticals + tecovirimat + +
+ + + + 2023 + 01 + 04 + + + 2023 + 02 + 02 + + + 2023 + 2 + 22 + 13 + 38 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809250 + reveh-2023-0001 + 10.1515/reveh-2023-0001 + + + + Adler, H, Gould, S, Hine, P, Snell, LB, Wong, W, Houlihan, CF, et al.. Clinical features and management of human monkeypox: a retrospective observational study in the UK. Lancet Infect Dis 2022;22:1153–62. https://doi.org/10.1016/s1473-3099(22)00228-6 . + + 10.1016/s1473-3099(22)00228-6 + + + + Desai, AN, Thompson, GR, Neumeister, SM, Arutyunova, AM, Trigg, K, Cohen, SH. Compassionate use of tecovirimat for the treatment of monkeypox infection. JAMA 2022;328:1348. https://doi.org/10.1001/jama.2022.15336 . + + 10.1001/jama.2022.15336 + + + + Thornhill, JP, Barkati, S, Walmsley, S, Rockstroh, J, Antinori, A, Harrison, LB, et al.. Monkeypox virus infection in humans across 16 countries — april–june 2022. N Engl J Med 2022;387:679–91. https://doi.org/10.1056/nejmoa2207323 . + + 10.1056/nejmoa2207323 + + + + Guarner, J, del Rio, C, Malani, PN. Monkeypox in 2022—what clinicians need to know. JAMA 2022;328:139. https://doi.org/10.1001/jama.2022.10802 . + + 10.1001/jama.2022.10802 + + + + Kozlov, M. How does monkeypox spread? What scientists know. Nature 2022;608:655–6. https://doi.org/10.1038/d41586-022-02178-w . + + 10.1038/d41586-022-02178-w + + + + Branswell, H. With monkeypox spreading globally, many experts believe the virus can’t be contained. STAT health . Available from:  https://www.statnews.com/2022/07/19/monkeypox-spread-many-experts-believe-the-virus-cant-be-contained/ [Accessed 07 Sep 2022]. + + + Jeyaraman, M, Selvaraj, P, Halesh, MB, Jeyaraman, N, Nallakumarasamy, A, Gupta, M, et al.. Monkeypox: an emerging global public health emergency. Life 2022;12:1590. https://doi.org/10.3390/life12101590 . + + 10.3390/life12101590 + + + + Abduljalil, JM, Elfiky, AA. Repurposing antiviral drugs against the human monkeypox virus DNA-dependent RNA polymerase; in silico perspective. J Infect 2022;85:702–69. https://doi.org/10.1016/j.jinf.2022.09.002 . + + 10.1016/j.jinf.2022.09.002 + + + + Sahoo, AK, Augusthian, PD, Muralitharan, I, Vivek-Ananth, RP, Kumar, K, Kumar, G, et al.. In silico identification of potential inhibitors of vital monkeypox virus proteins from FDA approved drugs. Mol Divers 2022;1–16. https://doi.org/10.1007/s11030-022-10550-1 . + + 10.1007/s11030-022-10550-1 + + + + Lam, HYI, Guan, JS, Mu, Y. Silico repurposed drugs against monkeypox virus. Molecules 2022;27:5277. https://doi.org/10.3390/molecules27165277 . + + 10.3390/molecules27165277 + + + + Miskovsky, P. Hypericin - a new antiviral and antitumor photosensitizer: mechanism of action and interaction with biological macromolecules. Curr Drug Targets 2002;3. https://doi.org/10.2174/1389450023348091 . + + 10.2174/1389450023348091 + + + + Akash, S, Islam, MR, Rahman, MM, Hossain, MS, Azad, AK, Sharma, R. Investigation of the new inhibitors by modified derivatives of pinocembrin for the treatment of monkeypox and marburg virus with different computational approaches. Biointerface Res Appl Chem 2023;13. [Ahead of print]. + + + +
+ + + 36809243 + + 2023 + 02 + 22 + +
+ + 1932-6203 + + 18 + 2 + + 2023 + + + PloS one + PLoS One + + Community-based serum chloride abnormalities predict mortality risk. + + e0279837 + + 10.1371/journal.pone.0279837 + + This population-based study aimed to investigate the prognostic value of ambulatory serum chloride abnormalities, often ignored by physicians. + The study population included all non-hospitalized adult patients, insured by "Clalit" Health Services in Israel's southern district, who underwent at least 3 serum chloride tests in community-based clinics during 2005-2016. For each patient, each period with low (≤97 mmol/l), high (≥107 mmol/l) or normal chloride levels were recorded. A Cox proportional hazards model was used to estimate the mortality risk of hypochloremia and hyperchloremia periods. + 664,253 serum chloride tests from 105,655 subjects were analyzed. During a median follow up of 10.8 years, 11,694 patients died. Hypochloremia (≤ 97 mmol/l) was independently associated with elevated all-cause mortality risk after adjusting for age, co-morbidities, hyponatremia and eGFR (HR 2.41, 95%CI 2.16-2.69, p<0.001). Crude hyperchloremia (≥107 mmol/L) was not associated with all-cause mortality (HR 1.03, 95%CI 0.98-1.09 p = 0.231); as opposed to hyperchloremia ≥108 mmol/l (HR 1.14, 95%CI 1.06-1.21 p<0.001). Secondary analysis revealed a dose-dependent elevated mortality risk for chloride levels of 105 mmol/l and below, well within the "normal" range. + In the outpatient setting, hypochloremia is independently associated with an increased mortality risk. This risk is dose-dependent where the lower the chloride level, the higher is the risk. + Copyright: © 2023 Shafat et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Shafat + Tali + T + + Clinical Research Center, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheba, Israel. + + + Department of Internal Medicine F, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheba, Israel. + + + + Novack + Victor + V + + Clinical Research Center, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheba, Israel. + + + + Barski + Leonid + L + + Department of Internal Medicine F, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheba, Israel. + + + + Haviv + Yosef S + YS + https://orcid.org/0000-0002-8875-6093 + + Nephrology Department, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheba, Israel. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2021 + 06 + 21 + + + 2022 + 12 + 15 + + + 2023 + 2 + 22 + 13 + 37 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809243 + 10.1371/journal.pone.0279837 + PONE-D-21-20343 + + +
+ + + 36809254 + + 2023 + 02 + 22 + +
+ + 1932-6203 + + 18 + 2 + + 2023 + + + PloS one + PLoS One + + Multilayer perceptron-genetic algorithm as a promising tool for modeling cultivation substrate of Auricularia cornea Native to Iran. + + e0281982 + + 10.1371/journal.pone.0281982 + + Auricularia cornea Ehrenb (syn. A. polytricha) is a wood-decaying fungi known as black ear mushroom. Earlike gelatinous fruiting body distinguishes them from other fungi. Industrial wastes have the potential to be used as the basic substrate to produce mushrooms. Therefore, 16 substrate formulations were prepared from different ratios of beech (BS) and hornbeam sawdust (HS) supplemented with wheat (WB) and rice brans (RB). The pH and initial moisture content of substrate mixtures were adjusted to 6.5 and 70%, respectively. The comparison of in vitro growth characteristics of the fungal mycelia under the different temperatures (25, 28, and 30°C), and culture media [yeast extract agar (YEA), potato extract agar (PEA), malt extract agar (MEA), and also HS and BS extract agar media supplemented with maltose, dextrose, and fructose revealed that the highest mycelial growth rate (MGR; 7.5 mm/day) belonged to HS and BS extract agar media supplemented with three mentioned sugar at 28°C. In A. cornea spawn study, the substrate combination of BS (70%) + WB (30%) at 28°C and moisture contents of 75% displayed the highest mean MGR (9.3 mm/day) and lowest spawn run period (9.0 days). In the bag test, "BS (70%) + WB (30%)" was the best substrate displaying the shortest spawn run period (19.7 days), and the highest fresh sporophore yield (131.7 g/bag), biological efficiency (53.1%) and number of basidiocarp (9.0/bag) of A. cornea. Also, A. cornea cultivation was processed to model yield, biological efficiency (BE), spawn run period (SRP), days for pinhead formation (DPHF), days for the first harvest (DFFH), and total cultivation period (TCP) by multilayer perceptron-genetic algorithm (MLP-GA). MLP-GA (0.81-0.99) exhibited a higher predictive ability than stepwise regression (0.06-0.58). The forecasted values of the output variables were in good accordance with their observed ones corroborating the good competency of established MLP-GA models. MLP-GA modeling exhibited a powerful tool for forecasting and thus selecting the optimal substrate for maximum A. cornea production. + Copyright: © 2023 Jahedi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Jahedi + Akbar + A + + Department of Plant Pathology, Tarbiat Modares University, Jalal, Iran. + + + + Salehi + Mina + M + + Department of Plant Genetics and Breeding, Tarbiat Modares University, Jalal, Iran. + + + + Goltapeh + Ebrahim Mohammadi + EM + + Department of Plant Pathology, Tarbiat Modares University, Jalal, Iran. + + + + Safaie + Naser + N + https://orcid.org/0000-0001-6065-7010 + + Department of Plant Pathology, Tarbiat Modares University, Jalal, Iran. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 09 + 10 + + + 2023 + 02 + 05 + + + 2023 + 2 + 22 + 13 + 38 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809254 + 10.1371/journal.pone.0281982 + PONE-D-22-24789 + + +
+ + + 36809251 + + 2023 + 02 + 22 + +
+ + 1932-6203 + + 18 + 2 + + 2023 + + + PloS one + PLoS One + + Deep-learning-based prognostic modeling for incident heart failure in patients with diabetes using electronic health records: A retrospective cohort study. + + e0281878 + + 10.1371/journal.pone.0281878 + + Patients with type 2 diabetes mellitus (T2DM) have more than twice the risk of developing heart failure (HF) compared to patients without diabetes. The present study is aimed to build an artificial intelligence (AI) prognostic model that takes in account a large and heterogeneous set of clinical factors and investigates the risk of developing HF in diabetic patients. We carried out an electronic health records- (EHR-) based retrospective cohort study that included patients with cardiological clinical evaluation and no previous diagnosis of HF. Information consists of features extracted from clinical and administrative data obtained as part of routine medical care. The primary endpoint was diagnosis of HF (during out-of-hospital clinical examination or hospitalization). We developed two prognostic models using (1) elastic net regularization for Cox proportional hazard model (COX) and (2) a deep neural network survival method (PHNN), in which a neural network was used to represent a non-linear hazard function and explainability strategies are applied to estimate the influence of predictors on the risk function. Over a median follow-up of 65 months, 17.3% of the 10,614 patients developed HF. The PHNN model outperformed COX both in terms of discrimination (c-index 0.768 vs 0.734) and calibration (2-year integrated calibration index 0.008 vs 0.018). The AI approach led to the identification of 20 predictors of different domains (age, body mass index, echocardiographic and electrocardiographic features, laboratory measurements, comorbidities, therapies) whose relationship with the predicted risk correspond to known trends in the clinical practice. Our results suggest that prognostic models for HF in diabetic patients may improve using EHRs in combination with AI techniques for survival analysis, which provide high flexibility and better performance with respect to standard approaches. + Copyright: © 2023 Gandin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Gandin + Ilaria + I + https://orcid.org/0000-0003-3196-2491 + + Department of Medical Sciences, Biostatistics Unit, University of Trieste, Trieste, Italy. + + + + Saccani + Sebastiano + S + + Aindo, Trieste, Italy. + + + + Coser + Andrea + A + + Aindo, Trieste, Italy. + + + + Scagnetto + Arjuna + A + + Cardiovascular Center, University Hospital and Health Services of Trieste, Trieste, Italy. + + + + Cappelletto + Chiara + C + + Cardiovascular Center, University Hospital and Health Services of Trieste, Trieste, Italy. + + + + Candido + Riccardo + R + + Diabetes Center, University Hospital and Health Services of Trieste, Trieste, Italy. + + + + Barbati + Giulia + G + + Department of Medical Sciences, Biostatistics Unit, University of Trieste, Trieste, Italy. + + + + Di Lenarda + Andrea + A + https://orcid.org/0000-0001-8482-4872 + + Cardiovascular Center, University Hospital and Health Services of Trieste, Trieste, Italy. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 10 + 11 + + + 2023 + 02 + 02 + + + 2023 + 2 + 22 + 13 + 38 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809251 + 10.1371/journal.pone.0281878 + PONE-D-22-28129 + + +
+ + + 36809237 + + 2023 + 02 + 22 + +
+ + 1553-7358 + + 19 + 2 + + 2023 + Feb + 21 + + + PLoS computational biology + PLoS Comput Biol + + Kinome inhibition states and multiomics data enable prediction of cell viability in diverse cancer types. + + e1010888 + + 10.1371/journal.pcbi.1010888 + + Protein kinases play a vital role in a wide range of cellular processes, and compounds that inhibit kinase activity emerging as a primary focus for targeted therapy development, especially in cancer. Consequently, efforts to characterize the behavior of kinases in response to inhibitor treatment, as well as downstream cellular responses, have been performed at increasingly large scales. Previous work with smaller datasets have used baseline profiling of cell lines and limited kinome profiling data to attempt to predict small molecule effects on cell viability, but these efforts did not use multi-dose kinase profiles and achieved low accuracy with very limited external validation. This work focuses on two large-scale primary data types, kinase inhibitor profiles and gene expression, to predict the results of cell viability screening. We describe the process by which we combined these data sets, examined their properties in relation to cell viability and finally developed a set of computational models that achieve a reasonably high prediction accuracy (R2 of 0.78 and RMSE of 0.154). Using these models, we identified a set of kinases, several of which are understudied, that are strongly influential in the cell viability prediction models. In addition, we also tested to see if a wider range of multiomics data sets could improve the model results and found that proteomic kinase inhibitor profiles were the single most informative data type. Finally, we validated a small subset of the model predictions in several triple-negative and HER2 positive breast cancer cell lines demonstrating that the model performs well with compounds and cell lines that were not included in the training data set. Overall, this result demonstrates that generic knowledge of the kinome is predictive of very specific cell phenotypes, and has the potential to be integrated into targeted therapy development pipelines. + Copyright: © 2023 Berginski et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Berginski + Matthew E + ME + https://orcid.org/0000-0002-4798-3273 + + Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America. + + + + Joisa + Chinmaya U + CU + + Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, North Carolina, United States of America. + + + + Golitz + Brian T + BT + + Eshelman Institute for Innovation, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America. + + + + Gomez + Shawn M + SM + + Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America. + + + Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, North Carolina, United States of America. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS Comput Biol + 101238922 + 1553-734X + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 05 + 23 + + + 2023 + 01 + 20 + + + 2023 + 2 + 22 + 13 + 37 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809237 + 10.1371/journal.pcbi.1010888 + PCOMPBIOL-D-22-00783 + + +
+ + + 36809247 + + 2023 + 02 + 22 + +
+ + 1549-1676 + + 20 + 2 + + 2023 + Feb + 21 + + + PLoS medicine + PLoS Med + + Health worker compliance with severe malaria treatment guidelines in the context of implementing pre-referral rectal artesunate in the Democratic Republic of the Congo, Nigeria, and Uganda: An operational study. + + e1004189 + + 10.1371/journal.pmed.1004189 + + For a full treatment course of severe malaria, community-administered pre-referral rectal artesunate (RAS) should be completed by post-referral treatment consisting of an injectable antimalarial and oral artemisinin-based combination therapy (ACT). This study aimed to assess compliance with this treatment recommendation in children under 5 years. + This observational study accompanied the implementation of RAS in the Democratic Republic of the Congo (DRC), Nigeria, and Uganda between 2018 and 2020. Antimalarial treatment was assessed during admission in included referral health facilities (RHFs) in children under 5 with a diagnosis of severe malaria. Children were either referred from a community-based provider or directly attending the RHF. RHF data of 7,983 children was analysed for appropriateness of antimalarials; a subsample of 3,449 children was assessed additionally for dosage and method of ACT provision (treatment compliance). A parenteral antimalarial and an ACT were administered to 2.7% (28/1,051) of admitted children in Nigeria, 44.5% (1,211/2,724) in Uganda, and 50.3% (2,117/4,208) in DRC. Children receiving RAS from a community-based provider were more likely to be administered post-referral medication according to the guidelines in DRC (adjusted odds ratio (aOR) = 2.13, 95% CI 1.55 to 2.92, P < 0.001), but less likely in Uganda (aOR = 0.37, 95% CI 0.14 to 0.96, P = 0.04) adjusting for patient, provider, caregiver, and other contextual factors. While in DRC, inpatient ACT administration was common, ACTs were often prescribed at discharge in Nigeria (54.4%, 229/421) and Uganda (53.0%, 715/1,349). Study limitations include the unfeasibility to independently confirm the diagnosis of severe malaria due to the observational nature of the study. + Directly observed treatment was often incomplete, bearing a high risk for partial parasite clearance and disease recrudescence. Parenteral artesunate not followed up with oral ACT constitutes an artemisinin monotherapy and may favour the selection of resistant parasites. In connection with the finding that pre-referral RAS had no beneficial effect on child survival in the 3 study countries, concerns about an effective continuum of care for children with severe malaria seem justified. Stricter compliance with the WHO severe malaria treatment guidelines is critical to effectively manage this disease and further reduce child mortality. + ClinicalTrials.gov (NCT03568344). + Copyright: © 2023 Signorell et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Signorell + Aita + A + https://orcid.org/0000-0003-3890-3910 + + Swiss Tropical and Public Health Institute, Allschwil, Switzerland. + + + University of Basel, Basel, Switzerland. + + + + Awor + Phyllis + P + + Makerere University School of Public Health, Kampala, Uganda. + + + + Okitawutshu + Jean + J + https://orcid.org/0000-0001-8937-222X + + Swiss Tropical and Public Health Institute, Allschwil, Switzerland. + + + University of Basel, Basel, Switzerland. + + + Kinshasa School of Public Health, Kinshasa, Democratic Republic of the Congo. + + + + Tshefu + Antoinette + A + + Kinshasa School of Public Health, Kinshasa, Democratic Republic of the Congo. + + + + Omoluabi + Elizabeth + E + https://orcid.org/0000-0003-1754-5384 + + Akena Associates, Abuja, Nigeria. + + + + Hetzel + Manuel W + MW + https://orcid.org/0000-0002-5285-3254 + + Swiss Tropical and Public Health Institute, Allschwil, Switzerland. + + + University of Basel, Basel, Switzerland. + + + + Athieno + Proscovia + P + https://orcid.org/0000-0003-3312-3915 + + Makerere University School of Public Health, Kampala, Uganda. + + + + Kimera + Joseph + J + https://orcid.org/0000-0002-5075-9512 + + Makerere University School of Public Health, Kampala, Uganda. + + + + Tumukunde + Gloria + G + + Makerere University School of Public Health, Kampala, Uganda. + + + + Angiro + Irene + I + + Makerere University School of Public Health, Kampala, Uganda. + + + + Kalenga + Jean-Claude + JC + + Kinshasa School of Public Health, Kinshasa, Democratic Republic of the Congo. + + + + Akano + Babatunde K + BK + https://orcid.org/0000-0002-5140-9135 + + Akena Associates, Abuja, Nigeria. + + + + Ayodeji + Kazeem + K + + Akena Associates, Abuja, Nigeria. + + + + Okon + Charles + C + https://orcid.org/0000-0003-3568-7888 + + Akena Associates, Abuja, Nigeria. + + + + Yusuf + Ocheche + O + + Akena Associates, Abuja, Nigeria. + + + + Delvento + Giulia + G + + Swiss Tropical and Public Health Institute, Allschwil, Switzerland. + + + University of Basel, Basel, Switzerland. + + + + Lee + Tristan T + TT + https://orcid.org/0000-0002-7391-8379 + + Swiss Tropical and Public Health Institute, Allschwil, Switzerland. + + + University of Basel, Basel, Switzerland. + + + + Brunner + Nina C + NC + https://orcid.org/0000-0001-8488-690X + + Swiss Tropical and Public Health Institute, Allschwil, Switzerland. + + + University of Basel, Basel, Switzerland. + + + + Lambiris + Mark J + MJ + https://orcid.org/0000-0003-1337-1778 + + Swiss Tropical and Public Health Institute, Allschwil, Switzerland. + + + University of Basel, Basel, Switzerland. + + + + Okuma + James + J + + Swiss Tropical and Public Health Institute, Allschwil, Switzerland. + + + University of Basel, Basel, Switzerland. + + + + Cereghetti + Nadja + N + https://orcid.org/0000-0001-8129-7034 + + Swiss Tropical and Public Health Institute, Allschwil, Switzerland. + + + University of Basel, Basel, Switzerland. + + + + Buj + Valentina + V + https://orcid.org/0000-0001-6650-4584 + + UNICEF, New York, New York, United States of America. + + + + Visser + Theodoor + T + https://orcid.org/0000-0002-5669-027X + + Clinton Health Access Initiative, Boston, Massachusetts, United States of America. + + + + Napier + Harriet G + HG + https://orcid.org/0000-0001-8788-6796 + + Clinton Health Access Initiative, Boston, Massachusetts, United States of America. + + + + Lengeler + Christian + C + https://orcid.org/0000-0002-8883-7950 + + Swiss Tropical and Public Health Institute, Allschwil, Switzerland. + + + University of Basel, Basel, Switzerland. + + + + Burri + Christian + C + + Swiss Tropical and Public Health Institute, Allschwil, Switzerland. + + + University of Basel, Basel, Switzerland. + + + + eng + + + ClinicalTrials.gov + + NCT03568344 + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS Med + 101231360 + 1549-1277 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 07 + 22 + + + 2023 + 02 + 02 + + + 2023 + 2 + 22 + 13 + 37 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809247 + 10.1371/journal.pmed.1004189 + PMEDICINE-D-22-02521 + + +
+ + + 36809248 + + 2023 + 02 + 22 + +
+ + 1465-2099 + + 104 + 2 + + 2023 + Feb + + + The Journal of general virology + J Gen Virol + + Modulation of cellular autophagy by genotype 1 hepatitis E virus ORF3 protein. + 10.1099/jgv.0.001824 + + Hepatitis E virus (HEV) egresses from infected hepatocytes as quasienveloped particles containing open reading frame 3 (ORF3) protein. HEV ORF3 (small phosphoprotein) interacts with host proteins to establish a favourable environment for virus replication. It is a functional viroporin that plays an important role during virus release. Our study provides evidence that pORF3 plays a pivotal role in inducing Beclin1-mediated autophagy that helps HEV-1 replication as well as its exit from cells. The ORF3 interacts with host proteins involved in regulation of transcriptional activity, immune response, cellular and molecular processes, and modulation of autophagy, by interacting with proteins, DAPK1, ATG2B, ATG16L2 and also several histone deacetylases (HDACs). For autophagy induction, the ORF3 utilizes non-canonical NF-κB2 pathway and sequesters p52NF-κB and HDAC2 to upregulate DAPK1 expression, leading to enhanced Beclin1 phosphorylation. By sequestering several HDACs, HEV may prevent histone deacetylation to maintain overall cellular transcription intact to promote cell survival. Our findings highlight a novel crosstalk between cell survival pathways participating in ORF3-mediated autophagy. + + + + Srivastava + Manjita + M + + Division of Hepatitis, National Institute of Virology, Pune, India. + + + + Bhukya + Prudhvi Lal + PL + + Division of Hepatitis, National Institute of Virology, Pune, India. + + + ICMR-National Animal Resource Facility for Biomedical Research, Hyderabad, India. + + + + Barman + Muneesh Kumar + MK + + Laboratory for HIV Research, National Centre for Cell Sciences, Pune, India. + + + + Bhise + Neha + N + + Division of Hepatitis, National Institute of Virology, Pune, India. + + + + Lole + Kavita S + KS + + Division of Hepatitis, National Institute of Virology, Pune, India. + + + + eng + + Journal Article + +
+ + England + J Gen Virol + 0077340 + 0022-1317 + + IM + + ATG7 + Beclin1 + DAPK1 + HEV ORF3 + autophagy + +
+ + + + 2023 + 2 + 22 + 13 + 37 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809248 + 10.1099/jgv.0.001824 + + +
+ + + 36809241 + + 2023 + 02 + 22 + +
+ + 1935-2735 + + 17 + 2 + + 2023 + Feb + + + PLoS neglected tropical diseases + PLoS Negl Trop Dis + + Untargeted serum metabolomics analysis of Trichinella spiralis-infected mouse. + + e0011119 + + 10.1371/journal.pntd.0011119 + + Trichinellosis, caused by a parasitic nematode of the genus Trichinella, is a zoonosis that affects people worldwide. After ingesting raw meat containing Trichinella spp. larvae, patients show signs of myalgia, headaches, and facial and periorbital edema, and severe cases may die from myocarditis and heart failure. The molecular mechanisms of trichinellosis are unclear, and the sensitivity of the diagnostic methods used for this disease are unsatisfactory. Metabolomics is an excellent tool for studying disease progression and biomarkers; however, it has never been applied to trichinellosis. We aimed to elucidate the impacts of Trichinella infection on the host body and identify potential biomarkers using metabolomics. + Mice were infected with T. spiralis larvae, and sera were collected before and 2, 4, and 8 weeks after infection. Metabolites in the sera were extracted and identified using untargeted mass spectrometry. Metabolomic data were annotated via the XCMS online platform and analyzed with Metaboanalyst version 5.0. A total of 10,221 metabolomic features were identified, and the levels of 566, 330, and 418 features were significantly changed at 2-, 4-, and 8-weeks post-infection, respectively. The altered metabolites were used for further pathway analysis and biomarker selection. A major pathway affected by Trichinella infection was glycerophospholipid metabolism, and glycerophospholipids comprised the main metabolite class identified. Receiver operating characteristic revealed 244 molecules with diagnostic power for trichinellosis, with phosphatidylserines (PS) being the primary lipid class. Some lipid molecules, e.g., PS (18:0/19:0)[U] and PA (O-16:0/21:0), were not present in metabolome databases of humans and mice, thus they may have been secreted by the parasites. + Our study highlighted glycerophospholipid metabolism as the major pathway affected by trichinellosis, hence glycerophospholipid species are potential markers of trichinellosis. The findings of this study represent the initial steps in biomarker discovery that may benefit future trichinellosis diagnosis. + Copyright: © 2023 Chienwichai et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Chienwichai + Peerut + P + + Princess Srisavangavadhana College of Medicine, Chulabhorn Royal Academy, Bangkok, Thailand. + + + + Thiangtrongjit + Tipparat + T + + Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. + + + + Tipthara + Phornpimon + P + + Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. + + + + Tarning + Joel + J + + Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. + + + Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom. + + + + Adisakwattana + Poom + P + + Department of Helminthology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. + + + + Reamtong + Onrapak + O + https://orcid.org/0000-0002-1154-6485 + + Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS Negl Trop Dis + 101291488 + 1935-2727 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 10 + 03 + + + 2023 + 01 + 23 + + + 2023 + 2 + 22 + 13 + 37 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809241 + 10.1371/journal.pntd.0011119 + PNTD-D-22-01255 + + +
+ + + 36809260 + + 2023 + 02 + 22 + +
+ + 1932-6203 + + 18 + 2 + + 2023 + + + PloS one + PLoS One + + Cervical kinematic change after posterior full-endoscopic cervical foraminotomy for disc herniation or foraminal stenosis. + + e0281926 + + 10.1371/journal.pone.0281926 + + Posterior full-endoscopic cervical foraminotomy (PECF) is one of minimally invasive surgical techniques for cervical radiculopathy. Because of minimal disruption of posterior cervical structures, such as facet joint, cervical kinematics was minimally changed. However, a larger resection of facet joint is required for cervical foraminal stenosis (FS) than disc herniation (DH). The objective was to compare the cervical kinematics between patients with FS and DH after PECF. + Consecutive 52 patients (DH, 34 vs. FS, 18) who underwent PECF for single-level radiculopathy were retrospectively reviewed. Clinical parameters (neck disability index, neck pain and arm pain), and segmental, cervical and global radiological parameters were compared at postoperative 3, 6, and 12 months, and yearly thereafter. A linear mixed-effect model was used to assess interactions between groups and time. Any occurrence of significant pain during follow-up was recorded during a mean follow-up period of 45.5 months (range 24-113 months). + Clinical parameters improved after PECF, with no significant differences between groups. Recurrent pain occurred in 6 patients and surgery (PECF, anterior discectomy and fusion) was performed in 2 patients. Pain-free survival rate was 91% for DH and 83% for FS, with no significant difference between the groups (P = 0.29). Radiological changes were not different between groups (P > 0.05). Segmental neutral and extension curvature became more lordotic. Cervical curvature became more lordotic on neutral and extension X-rays, and the range of cervical motion increased. The mismatch between T1-slope and cervical curvature decreased. Disc height did not change, but the index level showed degeneration at postoperative 2 years. + Clinical and radiological outcomes after PECF were not different between DH and FS patients and kinematics were significantly improved. These findings may be informative in a shared decision-making process. + Copyright: © 2023 Paik et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Paik + Seungyoon + S + + Department of Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. + + + + Choi + Yunhee + Y + + Division of Medical Statistics, Medical Research Collaborating Center, Seoul National University Hospital, Seoul, Republic of Korea. + + + + Chung + Chun Kee + CK + + Department of Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. + + + Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Republic of Korea. + + + Department of Neurosurgery, Seoul National University Hospital, Seoul, Republic of Korea. + + + Department of Brain and Cognitive Sciences, Seoul National University, Seoul, Republic of Korea. + + + + Won + Young Il + YI + + Department of Neurosurgery, Chungnam National University Sejong Hospital, Sejong, Republic of Korea. + + + + Park + Sung Bae + SB + + Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Republic of Korea. + + + Department of Neurosurgery, Seoul National University Hospital, Seoul, Republic of Korea. + + + Department of Neurosurgery, Seoul National University Boramae Hospital, Seoul, Republic of Korea. + + + + Yang + Seung Heon + SH + + Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Republic of Korea. + + + Department of Neurosurgery, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea. + + + + Lee + Chang-Hyun + CH + https://orcid.org/0000-0003-0134-2101 + + Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Republic of Korea. + + + Department of Neurosurgery, Seoul National University Hospital, Seoul, Republic of Korea. + + + + Rhee + John Min + JM + + Department of Orthopaedic Surgery, Emory University School of Medicine, Atlanta, Georgia, United States of America. + + + + Kim + Kyoung-Tae + KT + + Department of Neurosurgery, Kyungpook National University Hospital, Daegu, Republic of Korea. + + + Department of Neurosurgery, School of Medicine, Kyungpook National University, Daegu, Republic of Korea. + + + + Kim + Chi Heon + CH + https://orcid.org/0000-0003-0497-1130 + + Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Republic of Korea. + + + Department of Neurosurgery, Seoul National University Hospital, Seoul, Republic of Korea. + + + Department of Medical Device Development, Seoul National University College of Medicine, Seoul, Republic of Korea. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + I have read the journal’s policy and the authors of this manuscript have the following competing interests: The corresponding author (CHK) is a consultant of RIWOspine GmBH. All the other authors declare that they have no conflicts of interest concerning the materials/methods used in this study or the findings described in this paper. No benefits in any form have been or will be received from any commercial party related directly or indirectly to the subject of this manuscript. This does not alter our adherence to PLOS ONE policies on sharing data and materials. +
+ + + + 2022 + 01 + 18 + + + 2023 + 02 + 04 + + + 2023 + 2 + 22 + 13 + 38 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809260 + 10.1371/journal.pone.0281926 + PONE-D-22-01741 + + +
+ + + 36809261 + + 2023 + 02 + 22 + +
+ + 1932-6203 + + 18 + 2 + + 2023 + + + PloS one + PLoS One + + Conditional ablation of heparan sulfate expression in stromal fibroblasts promotes tumor growth in vivo. + + e0281820 + + 10.1371/journal.pone.0281820 + + Heparan sulfate (HS) is a glycocalyx component present in the extracellular matrix and cell-surface HS proteoglycans (HSPGs). Although HSPGs are known to play functional roles in multiple aspects of tumor development and progression, the effect of HS expression in the tumor stroma on tumor growth in vivo remains unclear. We conditionally deleted Ext1, which encodes a glycosyltransferase essential for the biosynthesis of HS chains, using S100a4-Cre (S100a4-Cre; Ext1f/f) to investigate the role of HS in cancer-associated fibroblasts, which is the main component of the tumor microenvironment. Subcutaneous transplantation experiments with murine MC38 colon cancer and Pan02 pancreatic cancer cells demonstrated substantially larger subcutaneous tumors in S100a4-Cre; Ext1f/f mice. Additionally, the number of myofibroblasts observed in MC38 and Pan02 subcutaneous tumors of S100a4-Cre; Ext1f/f mice decreased. Furthermore, the number of intratumoral macrophages decreased in MC38 subcutaneous tumors in S100a4-Cre; Ext1f/f mice. Finally, the expression of matrix metalloproteinase-7 (MMP-7) markedly increased in Pan02 subcutaneous tumors in S100a4-Cre; Ext1f/f mice, suggesting that it may contribute to rapid growth. Therefore, our study demonstrates that the tumor microenvironment with HS-reduced fibroblasts provides a favorable environment for tumor growth by affecting the function and properties of cancer-associated fibroblasts, macrophages, and cancer cells. + Copyright: © 2023 Niwa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Niwa + Ayumi + A + + Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu City, Japan. + + + + Taniguchi + Toshiaki + T + + Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu City, Japan. + + + + Tomita + Hiroyuki + H + https://orcid.org/0000-0002-3291-0274 + + Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu City, Japan. + + + + Okada + Hideshi + H + https://orcid.org/0000-0002-7775-4308 + + Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu City, Japan. + + + + Kinoshita + Takamasa + T + + Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu City, Japan. + + + Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu City, Japan. + + + + Mizutani + Chika + C + + Department of Gastroenterological Surgery/Pediatric Surgery, Gifu University Graduate School of Medicine, Gifu City, Japan. + + + + Matsuo + Mikiko + M + + Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu City, Japan. + + + + Imaizumi + Yuko + Y + + Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu City, Japan. + + + + Kuroda + Takahito + T + + Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu City, Japan. + + + + Ichihashi + Koki + K + + Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu City, Japan. + + + + Sugiyama + Takaaki + T + https://orcid.org/0000-0002-9935-6749 + + Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu City, Japan. + + + + Kanayama + Tomohiro + T + + Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu City, Japan. + + + + Yamaguchi + Yu + Y + + Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, United States of America. + + + + Sugie + Shigeyuki + S + + Department of Pathology, Asahi University Hospital, Gifu, Japan. + + + + Matsuhashi + Nobuhisa + N + + Department of Gastroenterological Surgery/Pediatric Surgery, Gifu University Graduate School of Medicine, Gifu City, Japan. + + + + Hara + Akira + A + + Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu City, Japan. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 07 + 19 + + + 2023 + 02 + 02 + + + 2023 + 2 + 22 + 13 + 38 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809261 + 10.1371/journal.pone.0281820 + PONE-D-22-20421 + + +
+ + + 36809259 + + 2023 + 02 + 22 + +
+ + 1932-6203 + + 18 + 2 + + 2023 + + + PloS one + PLoS One + + ADHD and political participation: An observational study. + + e0280445 + + 10.1371/journal.pone.0280445 + + Over the past decade, researchers have been seeking to understand the consequences of adult attention-deficit/hyperactivity disorder (ADHD) for different types of everyday behaviors. In this study, we investigated the associations between ADHD and political participation and attitudes, as ADHD may impede their active participation in the polity. + This observational study used data from an online panel studying the adult Jewish population in Israel, collected prior the national elections of April 2019 (N = 1369). ADHD symptoms were assessed using the 6-item Adult ADHD Self-Report (ASRS-6). Political participation (traditional and digital), news consumption habits, and attitudinal measures were assessed using structured questionnaires. Multivariate linear regression analyses were conducted to analyze the association between ADHD symptoms (ASRS score <17) and reported political participation and attitudes. + 200 respondents (14.6%) screened positive for ADHD based on the ASRS-6. Our findings show that individuals with ADHD are more likely to participate in politics than individuals without ADHD symptoms (B = 0.303, SE = 0.10, p = .003). However, participants with ADHD are more likely to be passive consumers of news, waiting for current political news to reach them instead of actively searching for it (B = 0.172, SE = 0.60, p = .004). They are also more prone to support the idea of silencing other opinions (B = 0.226, SE = 0.10, p = .029). The findings hold when controlling for age, sex, level of education, income, political orientation, religiosity, and stimulant therapy for ADHD symptoms. + Overall, we find evidence that individuals with ADHD display a unique pattern of political activity, including greater participation and less tolerance of others' views, but not necessarily showing greater active interest in politics. Our findings add to a growing body of literature that examines the impact of ADHD on different types of everyday behaviors. + Copyright: © 2023 Waismel-Manor et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Waismel-Manor + Israel + I + https://orcid.org/0000-0001-6202-8111 + + Department of Government and Political Theory Division, School of Political Science, University of Haifa, Haifa, Israel. + + + + Kaplan + Yael R + YR + https://orcid.org/0000-0002-6172-0744 + + Department of Government and Political Theory Division, School of Political Science, University of Haifa, Haifa, Israel. + + + + Shenhav + Shaul R + SR + + Department of Political Science, The Hebrew University of Jerusalem, Jerusalem, Israel. + + + + Zlotnik + Yair + Y + + Department of Neurology, Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheba, Israel. + + + + Dvir Gvirsman + Shira + S + + Department of Communication, Tel Aviv University, Tel Aviv, Israel. + + + + Ifergane + Gal + G + + Department of Neurology, Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheba, Israel. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 07 + 23 + + + 2022 + 12 + 31 + + + 2023 + 2 + 22 + 13 + 38 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809259 + 10.1371/journal.pone.0280445 + PONE-D-22-20625 + + +
+ + + 36809266 + + 2023 + 02 + 22 + +
+ + 1530-0293 + + 51 + 3 + + 2023 + Mar + 01 + + + Critical care medicine + Crit Care Med + + Extubation Anxiety, It Is All in the Brain. + + 424-427 + + 10.1097/CCM.0000000000005784 + + + Nyquist + Paul + P + + Anesthesia and Critical Care Medicine, Neurosurgery, General Integral Medicine, Johns Hopkins University School of Medicine, Baltimore, MD. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Crit Care Med + 0355501 + 0090-3493 + + IM + Dr. Nyquist has disclosed that he does not have any potential conflicts of interest. +
+ + + + 2023 + 2 + 22 + 13 + 38 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809266 + 10.1097/CCM.0000000000005784 + 00003246-202303000-00012 + + + + Ely EW, Baker AM, Dunagan DP, et al.: Effect on the duration of mechanical ventilation of identifying patients capable of breathing spontaneously. N Engl J Med. 1996; 335:1864–1869 + + + Klompas M, Li L, Kleinman K, et al.: Associations between ventilator bundle components and outcomes. JAMA Intern Med. 2016; 176:1277–1283 + + + Girard TD, Alhazzani W, Kress JP, et al.: An official American Thoracic Society/American College of Chest Physicians clinical practice guideline: Liberation from mechanical ventilation in critically ill adults. Rehabilitation protocols, ventilator liberation protocols, and cuff leak tests. Am J Respir Crit Care Med. 2017; 195:120–133 + + + Roquilly A, Cinotti R, Jaber S, et al.: Implementation of an evidence-based extubation readiness bundle in 499 brain-injured patients. A before-after evaluation of a quality improvement project. Am J Respir Crit Care Med. 2013; 188:958–966 + + + Balas MC, Tan A, Mion LC, et al.: Factors associated with spontaneous awakening trial and spontaneous breathing trial performance in adults with critical illness: Analysis of a multicenter, nationwide, cohort study. Chest. 2022; 162:588–602 + + + Esteban A, Anzueto A, Frutos F, et al.: Characteristics and outcomes in adult patients receiving mechanical ventilation: A 28-day international study. JAMA. 2002; 287:345–355 + + + Pelosi P, Ferguson ND, Frutos-Vivar F, et al.: Management and outcome of mechanically ventilated neurologic patients. Crit Care Med. 2011; 39:1482–1492 + + + Zygun DA, Kortbeek JB, Fick GH, et al.: Non-neurologic organ dysfunction in severe traumatic brain injury. Crit Care Med. 2005; 33:654–660 + + + Coplin WM, Pierson DJ, Cooley KD, et al.: Implications of extubation delay in brain-injured patients meeting standard weaning criteria. Am J Respir Crit Care Med. 2000; 161:1530–1536 + + + Namen AM, Ely EW, Tatter SB, et al.: Predictors of successful extubation in neurosurgical patients. Am J Respir Crit Care Med. 2001; 163(3 Pt 1):658–664 + + + Cinotti R, Bouras M, Roquilly A, et al.: Management and weaning from mechanical ventilation in neurologic patients. Ann Transl Med. 2018; 6:381–381 + + + Bosel J, Niesen WD, Salih F, et al.: Effect of early vs standard approach to tracheostomy on functional outcome at 6 months among patients with severe stroke receiving mechanical ventilation: The SETPOINT2 randomized clinical trial. JAMA. 2022; 327:1899–1909 + + + Taran S, Angeloni N, Pinto R, et al.: Prognostic Factors Associated With Extubation Failure in Acutely Brain-Injured Patients: A Systematic Review and Meta-Analysis. Crit Care Med. 2023; 51:401–412 + + + Karanjia N, Nordquist D, Stevens R, et al.: A clinical description of extubation failure in patients with primary brain injury. Neurocrit Care. 2011; 15:4–12 + + + Pandian V, Datta M, Nakka S, et al.: Intensive care unit readmission in patients with primary brain injury and tracheostomy. Am J Crit Care. 2019; 28:56–63 + + + +
+ + + 36809268 + + 2023 + 02 + 22 + +
+ + 1530-0293 + + 51 + 3 + + 2023 + Mar + 01 + + + Critical care medicine + Crit Care Med + + Activation of an Efferent Cholinergic Pathway Produces Strong Protection Against Myocardial Ischemia/Reperfusion Injury in Rats: Retraction. + + e90 + + 10.1097/CCM.0000000000005779 + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Crit Care Med + 0355501 + 0090-3493 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 38 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809268 + 10.1097/CCM.0000000000005779 + 00003246-202303000-00016 + + + REFERENCE + + Mioni C, Bazzani C, Giuliani D, et al.: Activation of an efferent cholinergic pathway produces strong protection against myocardial ischemia/reperfusion injury in rats. Crit Care Med. 2005; 33:2621–2628 + + + +
+ + + 36809265 + + 2023 + 02 + 22 + +
+ + 1530-0293 + + 51 + 3 + + 2023 + Mar + 01 + + + Critical care medicine + Crit Care Med + + When the Electric Circuit Is Not Working, It Is Time to Check All Outlets: How Status Epilepticus May Impact Cardiac Electric Activity. + + 420-424 + + 10.1097/CCM.0000000000005771 + + + Maciel + Carolina B + CB + + Departments of Neurology and Neurosurgery, Division of Neurocritical Care, University of Florida College of Medicine, Gainesville, FL. + + + + Barlow + Brooke + B + + Department of Pharmacy, Memorial Hermann The Woodlands, The Woodlands, TX. + + + + Busl + Katharina M + KM + + Departments of Neurology and Neurosurgery, Division of Neurocritical Care, University of Florida College of Medicine, Gainesville, FL. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Crit Care Med + 0355501 + 0090-3493 + + IM + Dr. Busl received funding from Guidepoint Global, Techspert, and the American Academy of Neurology; she disclosed that she is a member of the board of trustees for Art-in-Medicine, an Editorial Board Member for Neurocritical Care, and an Associate Editor for Critical Care Explorations. The remaining authors have disclosed that they do not have any potential conflicts of interest. +
+ + + + 2023 + 2 + 22 + 13 + 38 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809265 + 10.1097/CCM.0000000000005771 + 00003246-202303000-00011 + + + + Hawkes MA, Hocker SE: Systemic complications following status epilepticus. Curr Neurol Neurosci Rep. 2018; 18:7 + + + Sutter R, Dittrich T, Semmlack S, et al.: Acute systemic complications of convulsive status epilepticus-a systematic review. Crit Care Med. 2018; 46:138–145 + + + Samuels MA: The brain-heart connection. Circulation. 2007; 116:77–84 + + + Busl KM, Samuels MA: Acute brain injury and heart disease in cardiology. In: McGraw-Hill Specialty Board Review. Baliga RR (Ed). New York, NY, McGraw-Hill Education, 2012, pp 93–102 + + + Leutmezer F, Schernthaner C, Lurger S, et al.: Electrocardiographic changes at the onset of epileptic seizures. Epilepsia. 2003; 44:348–354 + + + Opherk C, Coromilas J, Hirsch LJ: Heart rate and EKG changes in 102 seizures: Analysis of influencing factors. Epilepsy Res. 2002; 52:117–127 + + + Cheng CY, Hsu CY, Wang TC, et al.: The risk of cardiac mortality in patients with status epilepticus: A 10-year study using data from the Centers for Disease Control and Prevention (CDC). Epilepsy Behav. 2021; 117:107901 + + + Chinardet P, Gilles F, Cochet H, et al.: Electrocardiographic Changes at the Early Stage of Status Epilepticus: First Insights From the ICTAL Registry. Crit Care Med. 2023; 51:388–400 + + + Rautaharju PM, Park LP, Chaitman BR, et al.: The Novacode criteria for classification of ECG abnormalities and their clinically significant progression and regression. J Electrocardiol. 1998; 31:157–187 + + + Christensen H, Boysen G, Christensen AF, et al.: Insular lesions, ECG abnormalities, and outcome in acute stroke. J Neurol Neurosurg Psychiatry. 2005; 76:269 + + + Oppenheimer SM, Gelb A, Girvin JP, et al.: Cardiovascular effects of human insular cortex stimulation. Neurology. 1992; 42:1727–1732 + + + Chouchou F, Mauguière F, Vallayer O, et al.: How the insula speaks to the heart: Cardiac responses to insular stimulation in humans. Hum Brain Mapp. 2019; 40:2611–2622 + + + +
+ + + 36809257 + + 2023 + 02 + 22 + +
+ + 1932-6203 + + 18 + 2 + + 2023 + + + PloS one + PLoS One + + What factors matter in the amount of alcohol consumed? An analysis among Brazilian adolescents. + + e0281065 + + 10.1371/journal.pone.0281065 + + Alcohol consumption in the under-18 age group has been growing in recent years, leading to various health risks. Considering the problems this habit brings, the present study contributes to the literature dedicated to categorizing different types of drinkers. The study objective is to verify the factors associated with the intensity of alcohol use among elementary school students in the year 2015. The dataset came from the National Adolescent School-based Health Survey (PeNSE). The applied methodology was a logit model of sequential response (continuation ratio). The main results are as follows. It was found that being female is associated with a lesser chance of having consumed alcohol in the reference period, however, with a greater chance of consuming five or more doses. Economic condition and formal paid employment are positively associated with alcohol consumption, which increases with the progression of the student's age. The number of friends who drink alcohol and consumption of products originating from tobacco and illicit drugs, are good predictors of alcohol use by students. The time spent practicing physical activities increased the chance of male students consuming alcohol. The results showed that, in general, the characteristics associated with different alcohol consumption profiles remain similar but differ between genders. Intervention strategies aimed at preventing alcohol consumption by minors are suggested in order to reduce the negative effects of substance use and abuse. + Copyright: © 2023 Bianchi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Bianchi + Lorenzo L + LL + https://orcid.org/0000-0002-0890-8086 + + National School of Public Administration, Evidência Express, Brasília, Brazil. + + + + da Silva + Cristiane + C + https://orcid.org/0000-0001-9272-4564 + + Universidade do Vale do Rio dos Sinos, Porto Alegre, Rio Grande do Sul, Brazil. + + + + Lazaretti + Lauana Rossetto + LR + https://orcid.org/0000-0002-6275-5914 + + Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul, Brazil. + + + + França + Marco Túlio Aniceto + MTA + + Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2021 + 09 + 14 + + + 2023 + 01 + 14 + + + 2023 + 2 + 22 + 13 + 38 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809257 + 10.1371/journal.pone.0281065 + PONE-D-21-29811 + + +
+ + + 36809258 + + 2023 + 02 + 22 + +
+ + 1558-8238 + + + 2023 + Feb + 21 + + + The Journal of clinical investigation + J Clin Invest + + Pathogenic human variant that dislocates GATA2 zinc fingers disrupts hematopoietic gene expression and signaling networks. + 10.1172/JCI162685 + e162685 + + Although certain human genetic variants are conspicuously loss-of-function, decoding the impact of many variants is challenging. Previously, we described a leukemia predisposition syndrome (GATA2-deficiency) patient with a germline GATA2 variant that inserts nine amino acids between the two zinc fingers (9aa-Ins). Here, we conducted mechanistic analyses using genomic technologies and a genetic rescue system with Gata2 enhancer-mutant hematopoietic progenitor cells to compare how GATA2 and 9aa-Ins function genome-wide. Despite nuclear localization, 9aa-Ins was severely defective in occupying and remodeling chromatin and regulating transcription. Variation of the inter-zinc finger spacer length revealed that insertions were more deleterious to activation than repression. GATA2-deficiency generated a lineage-diverting gene expression program and a hematopoiesis-disrupting signaling network in progenitors with reduced Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) and elevated Interleukin-6 (IL-6) signaling. As insufficient GM-CSF signaling causes pulmonary alveolar proteinosis and excessive IL-6 signaling promotes bone marrow failure, GATA2-deficiency patient phenotypes, these results inform mechanisms underlying GATA2-linked pathologies. + + + + Jung + Mabel Minji + MM + + Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, United States of America. + + + + Shen + Siqi + S + + Department of Biostatistics and Medical Informatics, University of Wisconsin School of Medicine and Public Health, Madison, United States of America. + + + + Botten + Giovanni A + GA + + Children's Research Institute, University of Texas Southwestern Medical Center, Dallas, United States of America. + + + + Olender + Thomas + T + + Ottawa Hospital Research Institute, Ottawa Hospital Research Institute, Ottawa, Canada. + + + + Katsumura + Koichi R + KR + + Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, United States of America. + + + + Johnson + Kirby D + KD + + Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, United States of America. + + + + Soukup + Alexandra A + AA + + Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, United States of America. + + + + Liu + Peng + P + + Department of Biostatistics and Medical Informatics, University of Wisconsin School of Medicine and Public Health, Madison, United States of America. + + + + Zhang + Qingzhou + Q + + Ottawa Hospital Research Institute, Ottawa Hospital Research Institute, Ottawa, Canada. + + + + Jensvold + Zena D + ZD + + Department of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health, Madison, United States of America. + + + + Lewis + Peter W + PW + + Department of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health, Madison, United States of America. + + + + Beagrie + Robert A + RA + + Radcliffe Department of Medicine, The University of Oxford, Oxford, United Kingdom. + + + + Low + Jason Kk + JK + + Life and Environmental Sciences, University of Sydney, Sydney, Australia. + + + + Yang + Lihua + L + + Life and Environmental Sciences, University of Sydney, Sydney, Australia. + + + + Mackay + Joel P + JP + + Life and Environmental Sciences, University of Sydney, Sydney, Australia. + + + + Godley + Lucy A + LA + + Section of Hematology/Oncology, The University of Chicago, Chicago, United States of America. + + + + Brand + Marjorie + M + + Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, United States of America. + + + + Xu + Jian + J + + Children's Research Institute, University of Texas Southwestern Medical Center, Dallas, United States of America. + + + + Keles + Sunduz + S + + Department of Biostatistics and Medical Informatics, University of Wisconsin School of Medicine and Public Health, Madison, United States of America. + + + + Bresnick + Emery H + EH + + Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, United States of America. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + J Clin Invest + 7802877 + 0021-9738 + + IM + + Genetic variation + Genetics + Hematology + Signal transduction + Transcription + +
+ + + + 2023 + 2 + 22 + 13 + 38 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809258 + 162685 + 10.1172/JCI162685 + + +
+ + + 36809262 + + 2023 + 02 + 22 + +
+ + 1530-0293 + + 51 + 3 + + 2023 + Mar + 01 + + + Critical care medicine + Crit Care Med + + Baricitinib or Tocilizumab? Treatment of Patients Hospitalized With Severe COVID-19. + + 413-415 + + 10.1097/CCM.0000000000005757 + + + Cawcutt + Kelly A + KA + + Both authors: Department of Internal Medicine, Division of Infectious Diseases, University of Nebraska Medical Center, Omaha, NE. + + + + Kalil + Andre C + AC + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Crit Care Med + 0355501 + 0090-3493 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 38 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809262 + 10.1097/CCM.0000000000005757 + 00003246-202303000-00008 + + + + National Institutes of Health: COVID-19 Treatment Guidelines. Available at https://www.covid19treatmentguidelines.nih.gov/. Accessed September 30, 2022 + + + Albuquerque AM, Eckert I, Tramujas L, et al.: Effect of tocilizumab, sarilumab, and baricitinib on mortality among patients hospitalized for COVID-19 treated with corticosteroids: A systematic review and meta-analysis. Clin Microbiol Infect. 2022 Jul 19; S1198-743X(22)00372-X + + + Peterson JH, Paranjape NS, Grundlingh N, et al.: Outcomes and adverse effects of baricitinib versus tocilizumab in the management of severe COVID-19. Crit Care Med. 2023; 51:337–346 + + + Abani O, Abbas A, Abbas F, et al.: Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): A randomised, controlled, open-label, platform trial and updated meta-analysis. Lancet. 2022; 400:359–368 + + + Shankar-Hari M, Vale C, Godolphin P, et al.: WHO rapid evidence appraisal for COVID-19 Therapies (REACT) Working Group: Association between administration of IL-6 antagonists and mortality among patients hospitalized for COVID-19: A meta-analysis. JAMA. 2021; 326:499–518 + + + Kumar G, Adams A, Hererra M, et al.: Predictors and outcomes of healthcare-associated infections in COVID-19 patients. Int J Infect Dis. 2021; 104:287–292 + + + Martínez-Martínez M, Plata-Menchaca EP, Nuvials FX, et al.: Risk factors and outcomes of ventilator-associated pneumonia in COVID-19 patients: A propensity score matched analysis. Crit Care. 2021; 25:235 + + + Prattes J, Wauters J, Giacobbe DR, et al.: Risk factors and outcome of pulmonary aspergillosis in critically ill coronavirus disease 2019 patients—A multinational observational study by the European Confederation of Medical Mycology. Clin Microbiol Infect. 2022; 28:580–587 + + + Kalil AC, Patterson TF, Mehta AK, et al.: Baricitinib plus remdesivir for hospitalized adults with COVID-19. N Engl J Med. 2021; 384:795–807 + + + Marconi VC, Ramanan AV, de Bono S, et al.: COV-BARRIER study group: Efficacy and safety of baricitinib for the treatment of hospitalised adults with COVID-19 (COV-BARRIER): A randomised, double-blind, parallel-group, placebo-controlled phase 3 trial. Lancet Respir Med. 2021; 9:1407–1418 + + + Ely EW, Ramanan AV, Kartman CE, et al.: COV-BARRIER study group: Efficacy and safety of baricitinib plus standard of care for the treatment of critically ill hospitalised adults with COVID-19 on invasive mechanical ventilation or extracorporeal membrane oxygenation: An exploratory, randomised, placebo-controlled trial. Lancet Respir Med. 2022; 10:327–336 + + + Wolfe CR, Tomashek KM, Patterson TF, et al.: Baricitinib versus dexamethasone for adults hospitalised with COVID-19 (ACTT-4): A randomised, double-blind, double placebo-controlled trial. Lancet Respir Med. 2022; 10:888–899 + + + Cantini F, Niccoli L, Matarrese D, et al.: Baricitinib therapy in COVID-19: A pilot study on safety and clinical impact. J Infection. 2020; 81:318–356 + + + Bronte V, Ugel S, Tinazzi E, et al.: Baricitinib restrains the immune dysregulation in patients with severe COVID-19. J Clin Invest. 2020; 130:6409–6416 + + + Rodriguez-Garcia JL, Sanchez-Nievas G, Arevalo-Serrano J, et al.: Baricitinib improves respiratory function in patients treated with corticosteroids for SARS-CoV-2 pneumonia: An observational cohort study. Rheumatology. 2021; 60:399–407 + + + Stebbing J, Sánchez Nievas G, Falcone M, et al.: JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality. Sci Adv. 2021; 7:eabe4724 + + + +
+ + + 36809256 + + 2023 + 02 + 22 + +
+ + 1969-6213 + + + 2023 + Feb + 21 + + + EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology + EuroIntervention + + Prediction of mortality and heart failure hospitalisations in patients undergoing M-TEER: external validation of the COAPT risk score. + EIJ-D-22-00992 + 10.4244/EIJ-D-22-00992 + + A risk score was recently derived from the Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients with Functional Mitral Regurgitation (COAPT) Trial. However, external validation of this score is still lacking. + We aimed to validate the COAPT risk score in a large multicentre population undergoing mitral transcatheter edge-to-edge repair (M-TEER) for secondary mitral regurgitation (SMR). + The Italian Society of Interventional Cardiology (GIse) Registry of Transcatheter Treatment of Mitral Valve RegurgitaTiOn (GIOTTO) population was stratified according to COAPT score quartiles. The performance of the COAPT score for 2-year all-cause death or heart failure (HF) hospitalisation was evaluated in the overall population and in patients with or without a COAPT-like profile. + Among the 1,659 patients included in the GIOTTO registry, 934 had SMR and complete data for a COAPT risk score calculation. Incidence of 2-year all-cause death or HF hospitalisation progressively increased through the COAPT score quartiles in the overall population (26.4% vs 44.5% vs 49.4% vs 59.7%; log-rank p<0.001) and COAPT-like patients (24.7% vs 32.4% vs 52.3% vs. 53.4%; log-rank p=0.004), but not in those with a non-COAPT-like profile. The COAPT risk score had poor discrimination and good calibration in the overall population, moderate discrimination and good calibration in COAPT-like patients and very poor discrimination and poor calibration in non-COAPT-like patients. + The COAPT risk score has a poor performance in the prognostic stratification of real-world patients undergoing M-TEER. However, after application to patients with a COAPT-like profile, moderate discrimination and good calibration were observed. + + + + Adamo + Marianna + M + + Cardiology and Cardiac catheterization laboratory, ASST Spedali Civili di Brescia, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy. + + + + Rubbio + Antonio Popolo + AP + + Department of Cardiology, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy. + + + + Zaccone + Gregorio + G + + Cardiology and Cardiac catheterization laboratory, ASST Spedali Civili di Brescia, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy. + + + + Pighi + Michele + M + + Division of Cardiology, Department of Medicine, University of Verona, Verona, Italy. + + + + Massussi + Mauro + M + + Cardiology and Cardiac catheterization laboratory, ASST Spedali Civili di Brescia, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy. + + + + Tomasoni + Daniela + D + + Cardiology and Cardiac catheterization laboratory, ASST Spedali Civili di Brescia, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy. + + + + Pancaldi + Edoardo + E + + Cardiology and Cardiac catheterization laboratory, ASST Spedali Civili di Brescia, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy. + + + + Testa + Luca + L + + Department of Cardiology, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy. + + + + Tusa + Maurizio B + MB + + Department of Cardiology, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy. + + + + De Marco + Federico + F + + Centro Cardiologico Monzino, IRCCS, Milan, Italy. + + + + Giannini + Cristina + C + + Cardiac Catheterization Laboratory, Cardiothoracic and Vascular Department, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy. + + + + Grasso + Carmelo + C + + Division of Cardiology, Centro Alte Specialità e Trapianti (CAST), Azienda Ospedaliero-Universitaria Policlinico Vittorio Emanuele, University of Catania, Catania, Italy. + + + + De Felice + Francesco + F + + Division of Interventional Cardiology, Azienda Ospedaliera S. Camillo Forlanini, Rome, Italy. + + + + Denti + Paolo + P + + Cardiac Surgery Department, San Raffaele University Hospital, Milan, Italy. + + + + Godino + Cosmo + C + + Cardio-Thoracic-Vascular Department, San Raffaele University Hospital, Milan, Italy. + + + + Mongiardo + Annalisa + A + + Division of Cardiology, University Magna Graecia, Catanzaro, Italy. + + + + Crimi + Gabriele + G + + Cardiology Unit, Cardiothoracic and Vascular Department (DICATOV) IRCCS, Ospedale Policlinico San Martino Genoa, Genova, Italy. + + + + Villa + Emmanuel + E + + Cardiac Surgery Unit and Transcatheter Valve Therapy Group, Poliambulanza Foundation Hospital, Brescia, Italy. + + + + Monteforte + Ida + I + + AORN Ospedali dei Colli, Monaldi Hospital, Naples, Italy. + + + + Citro + Rodolfo + R + + University Hospital San Giovanni di Dio e Ruggi d'Aragona, Salerno, Italy. + + + + Giordano + Arturo + A + + Invasive Cardiology Unit, Pineta Grande Hospital, Castel Volturno, Caserta, Italy. + + + + Bertorelli + Antonio L + AL + + Centro Cardiologico Monzino, IRCCS, Milan, Italy. + + + + Petronio + Anna Sonia + AS + + Cardiac Catheterization Laboratory, Cardiothoracic and Vascular Department, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy. + + + + Chizzola + Giuliano + G + + Cardiology and Cardiac catheterization laboratory, ASST Spedali Civili di Brescia, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy. + + + + Tarantini + Giuseppe + G + + Department of Cardiac, Thoracic and Vascular Science, Interventional Cardiology Unit, University of Padua, Padua, Italy. + + + + Tamburino + Corrado + C + + Division of Cardiology, Centro Alte Specialità e Trapianti (CAST), Azienda Ospedaliero-Universitaria Policlinico Vittorio Emanuele, University of Catania, Catania, Italy. + + + + Bedogni + Francesco + F + + Department of Cardiology, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy. + + + + Metra + Marco + M + + Cardiology and Cardiac catheterization laboratory, ASST Spedali Civili di Brescia, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + France + EuroIntervention + 101251040 + 1774-024X + + IM +
+ + + + 2023 + 2 + 22 + 13 + 38 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809256 + EIJ-D-22-00992 + 10.4244/EIJ-D-22-00992 + + +
+ + + 36809269 + + 2023 + 02 + 22 + +
+ + 1530-0293 + + 51 + 3 + + 2023 + Mar + 01 + + + Critical care medicine + Crit Care Med + + Recombinant Human Erythropoietin Improves Angiogenesis and Wound Healing in Experimental Burn Wounds: Retraction. + + e91 + + 10.1097/CCM.0000000000005780 + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Crit Care Med + 0355501 + 0090-3493 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 38 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809269 + 10.1097/CCM.0000000000005780 + 00003246-202303000-00017 + + + REFERENCE + + Galeano M, Altavilla D, Bitto A, et al.: Recombinant human erythropoietin improves angiogenesis and wound healing in experimental burn wounds. Crit Care Med. 2006; 34:1139–1146 + + + +
+ + + 36809267 + + 2023 + 02 + 22 + +
+ + 1530-0293 + + 51 + 3 + + 2023 + Mar + 01 + + + Critical care medicine + Crit Care Med + + Storage Wars: Is It Time to Retire the Myth of the "Storage Lesion" in Red Cell Transfusion? + + 427-430 + + 10.1097/CCM.0000000000005786 + + + Dilday + Joshua C + JC + + Both authors: Division of Trauma and Acute Care Surgery, Department of Surgery, Los Angeles County + USC Medical Center, Los Angeles, CA. + + + + Martin + Matthew J + MJ + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Crit Care Med + 0355501 + 0090-3493 + + IM + The authors have disclosed that they do not have any potential conflicts of interest. +
+ + + + 2023 + 2 + 22 + 13 + 38 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809267 + 10.1097/CCM.0000000000005786 + 00003246-202303000-00013 + + + + Sapiano MRP, Savinkina AA, Ellingson KD, et al.: Supplemental findings from the national blood collection and utilization surveys, 2013 and 2015. Transfusion. 2017; 57 Suppl 2(Suppl 2):1599–1624 + + + Lewis M, Shulman I, Hudgins J, et al.: Essentials of emergency transfusion-The complement to stop the bleed. J Trauma Acute Care Surg. 2019; 87:420–429 + + + Hod EA, Zhang N, Sokol SA, et al.: Transfusion of red blood cells after prolonged storage produces harmful effects that are mediated by iron and inflammation. Blood. 2010; 115:4284–4292 + + + Solomon SB, Wang D, Sun J, et al.: Mortality increases after massive exchange transfusion with older stored blood in canines with experimental pneumonia. Blood. 2013; 121:1663–1672 + + + Zallen G, Offner PJ, Moore EE, et al.: Age of transfused blood is an independent risk factor for postinjury multiple organ failure. Am J Surg. 1999; 178:570–572 + + + Pettilä V, Westbrook AJ, Nichol AD, et al.: Age of red blood cells and mortality in the critically ill. Crit Care. 2011; 15:R116 + + + Wang D, Sun J, Solomon SB, et al.: Transfusion of older stored blood and risk of death: A meta-analysis. Transfusion. 2012; 52:1184–1195 + + + Lacroix J, Hébert PC, Fergusson DA, et al.: Age of transfused blood in critically ill adults. N Engl J Med. 2015; 372:1410–1418 + + + Dhabangi A, Ainomugisha B, Cserti-Gazdewich C, et al.: Effect of transfusion of red blood cells with longer vs shorter storage duration on elevated blood lactate levels in children with severe anemia: The TOTAL randomized clinical trial. JAMA. 2015; 314:2514–2523 + + + Fergusson DA, Hébert P, Hogan DL, et al.: Effect of fresh red blood cell transfusions on clinical outcomes in premature, very low-birth-weight infants: The ARIPI randomized trial. JAMA. 2012; 308:1443–1451 + + + Lehr AR, Hébert P, Fergusson D, et al.: Association Between Length of Storage of Transfused Packed RBC Units and Outcome of Surgical Critically Ill Adults: A Subgroup Analysis of the Age of Blood Evaluation Randomized Trial. Crit Care Med. 2023; 51:e73–e80 + + + Cook RJ, Heddle NM, Lee KA, et al.: Red blood cell storage and in-hospital mortality: A secondary analysis of the INFORM randomised controlled trial. Lancet Haematol. 2017; 4:e544–ee52 + + + Heddle NM, Cook RJ, Arnold DM, et al.: Effect of short-term vs. long-term blood storage on mortality after transfusion. N Engl J Med. 2016; 375:1937–1945 + + + Cooper DJ, McQuilten ZK, Nichol A, et al.: Age of red cells for transfusion and outcomes in critically ill adults. N Engl J Med. 2017; 377:1858–1867 + + + Cartotto R, Taylor SL, Holmes JH, et al.: The effects of storage age of blood in massively transfused burn patients: A secondary analysis of the randomized transfusion requirement in burn care evaluation study. Crit Care Med. 2018; 46:e1097–ee104 + + + Sowers N, Froese PC, Erdogan M, et al.: Impact of the age of stored blood on trauma patient mortality: A systematic review. Can J Surg. 2015; 58:335–342 + + + Steiner ME, Ness PM, Assmann SF, et al.: Effects of red-cell storage duration on patients undergoing cardiac surgery. N Engl J Med. 2015; 372:1419–1429 + + + Zhang W, Yu K, Chen N, et al.: Age of red cells for transfusion and outcomes in critically ill patients: A meta-analysis. Transfus Med Hemother. 2019; 46:248–256 + + + +
+ + + 36809264 + + 2023 + 02 + 22 + +
+ + 1530-0293 + + 51 + 3 + + 2023 + Mar + 01 + + + Critical care medicine + Crit Care Med + + Surviving Critical Illness: Alive and Kicking or Alive and Agonizing? + + 418-419 + + 10.1097/CCM.0000000000005785 + + + Galvagno + Samuel M + SM + + Department of Anesthesiology, University of Maryland School of Medicine, R Adams Cowley Shock Trauma Center, Baltimore, MD. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Crit Care Med + 0355501 + 0090-3493 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 38 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809264 + 10.1097/CCM.0000000000005785 + 00003246-202303000-00010 + + + + Saab G: The Last Checkmate. New York, NY, Harper Collins, 2021 + + + Hofhuis JGM, Schrijvers AJP, Schermer T, et al.: Health-related quality of life in ICU survivors-10 years later. Sci Rep. 2021; 11:15189 + + + Cuthbertson BH, Scott J, Strachan M, et al.: Quality of life before and after intensive care. Anaesthesia. 2005; 60:332–339 + + + Langerud AK, Rustøen T, Småstuen MC, et al.: Health-related quality of life in intensive care survivors: Associations with social support, comorbidity, and pain interference. PLoS One. 2018; 13:e0199656 + + + Griffiths RD, Jones C: Recovering lives: The follow-up of ICU survivors. Am J Respir Crit Care Med. 2011; 183:833–834 + + + Adrion C, Weiss B, Paul N, et al.: Enhanced recovery after intensive care (ERIC): Study protocol for a German stepped wedge cluster randomised controlled trial to evaluate the effectiveness of a critical care telehealth program on process quality and functional outcomes. BMJ Open. 2020; 10:e036096 + + + Paul N, Cittadino J, Weiss B, et al.: Subjective Ratings of Mental and Physical Health Correlate With EQ-5D-5L Index Values in Survivors of Critical Illness: A Construct Validity Study. Crit Care Med. 2023; 51:365–375 + + + Cuthbertson BH: Life after intensive care--It’s life... but not as we know it!. Crit Care Med. 2008; 36:1668–1669 + + + Santacruz CA, Pereira AJ, Celis E, et al.: Which multicenter randomized controlled trials in critical care medicine have shown reduced mortality? A systematic review. Crit Care Med. 2019; 47:1680–1691 + + + +
+ + + 36809280 + + 2023 + 02 + 22 + +
+ + 1537-1611 + + 24 + 1S + + 2023 + Feb + 01 + + + Journal of clinical neuromuscular disease + J Clin Neuromuscul Dis + + 45th ANNUAL CARRELL-KRUSEN NEUROMUSCULAR SYMPOSIUM, Dallas, Texas, Thursday-Friday, February 23-24, 2023: Meeting Convener: Susan T. Iannaccone, MD, FAAN. + + S1-S24 + + 10.1097/CND.0000000000000443 + eng + + Journal Article + +
+ + United States + J Clin Neuromuscul Dis + 100887391 + 1522-0443 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 39 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809280 + 10.1097/CND.0000000000000443 + 00131402-202302001-00001 + + +
+ + + 36809271 + + 2023 + 02 + 22 + +
+ + 1530-0293 + + 51 + 3 + + 2023 + Mar + 01 + + + Critical care medicine + Crit Care Med + + Melanocortin 4 Receptor Stimulation Decreases Pancreatitis Severity in Rats by Activation of the Cholinergic Anti-Inflammatory Pathway: Retraction. + + e93 + + 10.1097/CCM.0000000000005782 + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Crit Care Med + 0355501 + 0090-3493 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 38 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809271 + 10.1097/CCM.0000000000005782 + 00003246-202303000-00019 + + + REFERENCE + + Minutoli L, Squadrito F, Nicotina PA, et al.: Melanocortin 4 receptor stimulation decreases pancreatitis severity in rats by activation of the cholinergic anti-inflammatory pathway. Crit Care Med. 2011; 39:1089–1096 + + + +
+ + + 36809263 + + 2023 + 02 + 22 + +
+ + 1530-0293 + + 51 + 3 + + 2023 + Mar + 01 + + + Critical care medicine + Crit Care Med + + From Pac-Man to UltraMan. + + 415-418 + + 10.1097/CCM.0000000000005777 + + + Graham + Jeffrey D + JD + + Division of Pulmonary and Critical Care, University of Utah, Salt Lake City, UT. + + + Department of Pulmonary and Critical Care, Intermountain Healthcare, Salt Lake City, UT. + + + + Grissom + Colin K + CK + + Division of Pulmonary and Critical Care, University of Utah, Salt Lake City, UT. + + + Department of Pulmonary and Critical Care, Intermountain Healthcare, Salt Lake City, UT. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Crit Care Med + 0355501 + 0090-3493 + + IM + The authors have disclosed that they do not have any potential conflicts of interest. +
+ + + + 2023 + 2 + 22 + 13 + 38 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809263 + 10.1097/CCM.0000000000005777 + 00003246-202303000-00009 + + + + Donald I, Macvicar J, Brown TG: Investigation of abdominal masses by pulsed ultrasound. Lancet. 1958; 1:1188–1195 + + + Lee L, DeCara JM: Point-of-care ultrasound. Curr Cardiol Rep. 2020; 22:149 + + + Fryback DG, Thornbury JR: The efficacy of diagnostic imaging. Med Decis Making. 1991; 11:88–94 + + + Harvey S, Harrison DA, Singer M, et al.; PAC-Man study collaboration: Assessment of the clinical effectiveness of pulmonary artery catheters in management of patients in intensive care (PAC-Man): A randomised controlled trial. Lancet. 2005; 366:472–477 + + + Wheeler AP, Bernard GR, Thompson BT, et al.; National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network: Pulmonary-artery versus central venous catheter to guide treatment of acute lung injury. N Engl J Med. 2006; 354:2213–2224 + + + Heldeweg MLA, Lopez Matta JE, Pisani L, et al.: The Impact of Thoracic Ultrasound on Clinical Management of Critically Ill Patients (UltraMan): An International Prospective Observational Study. Crit Care Med. 2023; 51:357–364 + + + Arbelot C, Dexheimer Neto FL, Gao Y, et al.; APECHO Study Group: Lung ultrasound in emergency and critically ill patients: Number of supervised exams to reach basic competence. Anesthesiology. 2020; 132:899–907 + + + Hew M, Tay TR: The efficacy of bedside chest ultrasound: From accuracy to outcomes. Eur Respir Rev. 2016; 25:230–246 + + + House DR, Amatya Y, Nti B, et al.: Lung ultrasound training and evaluation for proficiency among physicians in a low-resource setting. Ultrasound J. 2021; 13:34 + + + Via G, Hussain A, Wells M, et al.: International evidence-based recommendations for focused cardiac ultrasound. J Am Soc Echocardiogr. 2014; 27:683.e1–683.e33 + + + Vieillard-Baron A, Millington SJ, Sanfilippo F, et al.: A decade of progress in critical care echocardiography: A narrative review. Intensive Care Med. 2019; 45:770–788 + + + Sarkar PK, Boivin M, Mayo PH: Effectiveness of an advanced critical care echocardiography course. J Intensive Care Med. 2020; 35:1332–1337 + + + Yu K, Zhang S, Chen N, et al.; CCUGDT Study Group: Critical care ultrasound goal-directed versus early goal-directed therapy in septic shock. Intensive Care Med. 2022; 48:121–123 + + + +
+ + + 36809283 + + 2023 + 02 + 22 + +
+ + 1932-6203 + + 18 + 2 + + 2023 + + + PloS one + PLoS One + + Comparison of four multilocus sequence typing schemes and amino acid biosynthesis based on genomic analysis of Bacillus subtilis. + + e0282092 + + 10.1371/journal.pone.0282092 + + Bacillus subtilis, a valuable industrial microorganism used in starter cultures in soybean fermentation, is a species of bacteria with interspecies diversity. Here, four multilocus sequence typing (MLST) schemes developed to assess the diversity of B. subtilis or Bacillus spp. were applied and compared to confirm the interspecies diversity of B. subtilis. In addition, we analyzed correlations between amino acid biosynthesis genes and sequence types (STs); this is important because amino acids are key taste components in fermented foods. On applying the four MLST methods to 38 strains and the type strain of B. subtilis, 30 to 32 STs were identified. The discriminatory power was 0.362-0.964 for the genes used in the MLST methods; the larger the gene, the greater the number of alleles and polymorphic sites. All four MLST methods showed a correlation between STs and strains that do not possess the hutHUIG operon (which contains genes required for the production of glutamate from histidine). This correlation was verified using 168 further genome-sequence strains. + Copyright: © 2023 Lee et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Lee + Gawon + G + + Department of Food and Nutrition, Dongduk Women's University, Seoul, Republic of Korea. + + + + Heo + Sojeong + S + + Department of Food and Nutrition, Dongduk Women's University, Seoul, Republic of Korea. + + + + Kim + Tao + T + + Department of Food and Nutrition, Dongduk Women's University, Seoul, Republic of Korea. + + + + Na + Hong-Eun + HE + + Department of Food and Nutrition, Dongduk Women's University, Seoul, Republic of Korea. + + + + Lee + Jong-Hoon + JH + https://orcid.org/0000-0001-8889-5504 + + Department of Food Science and Biotechnology, Kyonggi University, Suwon, Republic of Korea. + + + + Jeong + Do-Won + DW + https://orcid.org/0000-0001-6586-748X + + Department of Food and Nutrition, Dongduk Women's University, Seoul, Republic of Korea. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 09 + 14 + + + 2023 + 02 + 06 + + + 2023 + 2 + 22 + 13 + 39 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809283 + 10.1371/journal.pone.0282092 + PONE-D-22-25606 + + +
+ + + 36809277 + + 2023 + 02 + 22 + +
+ + 1932-6203 + + 18 + 2 + + 2023 + + + PloS one + PLoS One + + Constructing the festival tourist attraction from the perspective of Peircean semiotics: The case of Guangzhou, China. + + e0282102 + + 10.1371/journal.pone.0282102 + + Based on the Peircean semiotic theory, this study aims to explore the semiotic construction of a festival tourist attraction using the Guangfu Temple Fair in China as a case. A qualitative research method of grounded theory was used to analyze the organizers' planning scheme, conference materials, 7 interviews, and 45 tourists' interviews. We found that festival organizers produce festivalscape based on social values and tourists' expectations, including safety assurance, cultural activity, personnel service, facilities, creative interaction, food, a trade show, and the festival atmosphere. Tourists in the festivalscape, through cultural, novel, social, and emotional experience and collateral observations, assign meaning to the festival's attractiveness in terms of cultural diversity, vibrant activities, distinctive features, and a sense of ceremony. These findings indicate that organizers' sign production and tourists' sign interpretation constitute the conceptual model of the semiotic construction of festivals as tourist attractions. Furthermore, the study extends the understanding of tourist attractions and will help organizers to create successful festival attractions. + Copyright: © 2023 Li, Yu. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Li + Jing + J + https://orcid.org/0000-0002-9462-2876 + + School of Foreign Languages & International Business, Guangdong Mechanical and Electrical Polytechnic, Guangzhou, China. + + + + Yu + Gouxiong + G + + School of Business Administration, Guangdong University of Finance, Guangzhou, China. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 05 + 06 + + + 2023 + 02 + 07 + + + 2023 + 2 + 22 + 13 + 38 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809277 + 10.1371/journal.pone.0282102 + PONE-D-22-12570 + + +
+ + + 36809273 + + 2023 + 02 + 22 + +
+ + 1932-6203 + + 18 + 2 + + 2023 + + + PloS one + PLoS One + + Antisense-acting riboswitches: A poorly characterized yet important model of transcriptional regulation in prokaryotic organisms. + + e0281744 + + 10.1371/journal.pone.0281744 + + Riboswitches are RNA elements involved in regulating genes that participate in the biosynthesis or transport of essential metabolites. They are characterized by their ability to recognize their target molecules with high affinity and specificity. Riboswitches are commonly cotranscribed with their target genes and are located at the 5' end of their transcriptional units. To date, only two exceptional cases of riboswitches being situated at the 3' end and transcribing in the antisense direction of their regulated genes have been described. The first case involves a SAM riboswitch located at the 3' end of the ubiG-mccB-mccA operon in Clostridium acetobutylicum involved in converting methionine to cysteine. The second case concerns a Cobalamin riboswitch in Listeria monocytogenes that regulates the transcription factor PocR related to this organism's pathogenic process. In almost a decade since the first descriptions of antisense-acting riboswitches, no new examples have been described. In this work, we performed a computational analysis to identify new examples of antisense-acting riboswitches. We found 292 cases in which, according to the available information, we infer that the expected regulation of the riboswitch is consistent with the signaling molecule it senses and the metabolic function of the regulated gene. The metabolic implications of this novel type of regulation are thoroughly discussed. + Copyright: © 2023 Serrano-Gutiérrez, Merino. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Serrano-Gutiérrez + Mariela + M + + Departamento de Microbiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, México. + + + + Merino + Enrique + E + https://orcid.org/0000-0002-0374-0640 + + Departamento de Microbiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, México. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 11 + 07 + + + 2023 + 01 + 30 + + + 2023 + 2 + 22 + 13 + 38 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809273 + 10.1371/journal.pone.0281744 + PONE-D-22-30662 + + +
+ + + 36809270 + + 2023 + 02 + 22 + +
+ + 1530-0293 + + 51 + 3 + + 2023 + Mar + 01 + + + Critical care medicine + Crit Care Med + + Metallothionein Alleviates Glutathione Depletion-Induced Oxidative Cardiomyopathy in Murine Hearts: Retraction. + + e92 + + 10.1097/CCM.0000000000005781 + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Crit Care Med + 0355501 + 0090-3493 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 38 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809270 + 10.1097/CCM.0000000000005781 + 00003246-202303000-00018 + + + REFERENCE + + Ren J, Privratsky JR, Yang X, et al.: Metallothionein alleviates glutathione depletion-induced oxidative cardiomyopathy in murine hearts. Crit Care Med. 2008; 36:2106–2116 + + + +
+ + + 36809281 + + 2023 + 02 + 22 + +
+ + 1932-6203 + + 18 + 2 + + 2023 + + + PloS one + PLoS One + + The impact of higher levels of autistic traits on risk of hikikomori (pathological social withdrawal) in young adults. + + e0281833 + + 10.1371/journal.pone.0281833 + + Hikikomori is an extreme state of social withdrawal, originally identified in Japan but more recently recognised internationally. Many countries imposed restrictions during the COVID-19 pandemic which may have had a detrimental impact on those at risk of hikikomori, specifically young adults and those with high levels of autistic traits. + To explore whether levels of autistic traits mediate the relationship between psychological wellbeing and hikikomori risk. We also looked at whether autistic traits mediated between lockdown experiences (e.g. not leaving the house) and hikikomori risk. + 646 young people (aged 16-24) from a wide range of countries completed an online questionnaire assessing psychological wellbeing, autistic traits and experiences of lockdown for this cross-sectional study. + Autistic traits mediated the relationship between both psychological wellbeing and hikikomori risk, as well as frequency of leaving the house during lockdown and hikikomori risk. Greater hikikomori risk was associated with poor psychological wellbeing, higher autistic traits and leaving the house less frequently during the COVID-19 pandemic. + These findings suggest similarities with Japanese hikikomori research and are consistent with suggestions that psychological wellbeing and COVID-19 restrictions are associated with increased hikikomori risk in young adults, and both associations are mediated by higher levels of autistic traits. + Copyright: © 2023 Brosnan, Gavin. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Brosnan + Mark + M + https://orcid.org/0000-0002-0683-1492 + + Department of Psychology, Centre for Applied Autism Research, University of Bath, Bath, United Kingdom. + + + + Gavin + Jeff + J + + Department of Psychology, Centre for Applied Autism Research, University of Bath, Bath, United Kingdom. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 11 + 14 + + + 2023 + 02 + 01 + + + 2023 + 2 + 22 + 13 + 39 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809281 + 10.1371/journal.pone.0281833 + PONE-D-22-30711 + + +
+ + + 36809285 + + 2023 + 02 + 22 + +
+ + 1530-0374 + + + 2023 + Feb + 21 + + + Menopause (New York, N.Y.) + Menopause + + Low-serum anti-Müllerian hormone in middle-aged women associates with obesity markers. + 10.1097/GME.0000000000002164 + + + Pru + James K + JK + + From the Program in Reproductive Biology, University of Wyoming, Laramie, WY. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Menopause + 9433353 + 1072-3714 + + IM + Financial disclosure/conflicts of interest: None reported. +
+ + + + 2023 + 2 + 22 + 13 + 39 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809285 + 10.1097/GME.0000000000002164 + 00042192-990000000-00159 + + + + Jost A. Problems of fetal endocrinology—the gonadal and hypophyseal hormones. Recent Prog Horm Res 1953;8:379–418. + + + Kobayashi A, Behringer RR. Developmental genetics of the female reproductive tract in mammals. Nat Rev Genet 2003;4:969–980. doi: 10.1038/nrg1225 + + 10.1038/nrg1225 + + + + Mullen RD, Berhinger RR. Molecular genetics of Müllerian duct formation, regression and differentiation. Sex Dev 2014;8:281–296. doi: 10.1159/000364935 + + 10.1159/000364935 + + + + Adolfi MC, Nakajima RT, Nobrega RH, Schartl M. Intersex, hermaphrodism, and gonadal plasticity in venerates: evolution of Müllerian duct and amh/amhr2 signaling. Annu Rev Anim Biosci 2019;7:149–172. doi: 10.1146/annurev-animal-020518-114955 + + 10.1146/annurev-animal-020518-114955 + + + + Nelson SM. Biomarkers of ovarian response: current and future applications. Fertil Steril 2013;99:963–969. doi: 10.1016/j.fertnstert.2012.11.051 + + 10.1016/j.fertnstert.2012.11.051 + + + + Broer SL, Broekmans FJM, Laven JS, Fauser BC. Anti-Müllerian hormone: ovarian reserve testing and its potential clinical implications. Hum Reprod Update 2014;20:688–701. doi: 10.1093/humupd/dmu020 + + 10.1093/humupd/dmu020 + + + + Laurich VM, Trbovich AM, O'Neill FH, et al. Müllerian inhibiting substance blocks the protein kinase A–induced expression of cytochrome p 450 17alpha-hydroxylase/C(17-20) lyase mRNA in a mouse Leydig cell line independent of cAMP responsive elements binding protein phosphorylation. Endocrinology 2002;143:3351–3360. doi: 10.1210/en.2001-211352 + + 10.1210/en.2001-211352 + + + + Trbovich AM, Sluss PM, Laurich VM, et al. Müllerian inhibiting substance lowers testosterone in luetinizing hormone-stimulated rodents. Proc Natl Acad Sci 2001;98:3393–3397. doi: 10.1073/pnas.051632298 + + 10.1073/pnas.051632298 + + + + di Clemente N, Racine C, Pierre A, Taieb J. Anti-Müllerian hormone in female reproduction. Endocr Rev 2021;42:753–782. doi: 10.1210/endrev/bnab012 + + 10.1210/endrev/bnab012 + + + + Kushnir VA, Seifer DB, Barad DH, Sen A, Gleicher N. Potential therapeutic applications of human anti-Müllerian hormone (AMH) analogues in reproductive medicine. J Assist Reprod Genet 2017;34:1105–1113. doi: 10.1007/s10815-017-0977-4 + + 10.1007/s10815-017-0977-4 + + + + Bleil ME, Grogorich SE, McConnell D, Rosen MP, Cedars MI. Does accelerated reproductive aging underlie premenopausal risk for cardiovascular disease? Menopause 2013;20:1139–1146. doi: 10.1097/GME.0b013e31828950fa + + 10.1097/GME.0b013e31828950fa + + + + Freeman EW, Gracia CR, Sammel MD, Lin H, Lim LC, Strauss JF 3rd. Association of anti-Müllerian hormone levels with obesity in late reproductive-age women. Fertil Steril 2007;87:1001–1106. doi: 10.1016/j.fertnstert.2006.05.074 + + 10.1016/j.fertnstert.2006.05.074 + + + + Amiri M, Ramezani TF, Rahmati M, Firouszi F, Azizi F. Do trends in adiposity and metabolic parameters vary in women with different ovarian reserve status? A population-based cohort study. Menopause 2020;27:684–692. doi: 10.1097/GME.0000000000001513 + + 10.1097/GME.0000000000001513 + + + + Kim S, Kim JJ, Kim MJ, et al. Relationship between serum anti-Müllerian hormone with vitamin D and metabolic syndrome risk factors in late reproductive-age women. Gynecol Endocrinol 2018;34:327–331. doi: 10.1080/09513590.2017.1397113 + + 10.1080/09513590.2017.1397113 + + + + Francis EC, Oken E, Hivert MF, Rifas-Shiman SL, Chavarro JE, Perng W. Anti-Müllerian hormone and adiposity across mid-life among women in Project Viva. Menopause 2023;30:247–253. doi: 10.1097/GME.0000000000002143 + + 10.1097/GME.0000000000002143 + + + + Oken E, Baccarelli AA, Gold DR, et al. Cohort profile: project viva. Int J Epidemiol 2015;44:37–48. doi: 10.1093/ije/dyu008 + + 10.1093/ije/dyu008 + + + + +
+ + + 36809272 + + 2023 + 02 + 22 + +
+ + 1530-0293 + + 51 + 3 + + 2023 + Mar + 01 + + + Critical care medicine + Crit Care Med + + Protective Effects of Melanocortins on Short-Term Changes in a Rat Model of Traumatic Brain Injury: Retraction. + + e94 + + 10.1097/CCM.0000000000005783 + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Crit Care Med + 0355501 + 0090-3493 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 38 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809272 + 10.1097/CCM.0000000000005783 + 00003246-202303000-00020 + + + REFERENCE + + Bitto A, Polito F, Irrera N, et al.: Protective effects of melanocortins on short-term changes in a rat model of traumatic brain injury. Crit Care Med. 2012; 40:945–951 + + + +
+ + + 36809279 + + 2023 + 02 + 22 + +
+ + 1932-6203 + + 18 + 2 + + 2023 + + + PloS one + PLoS One + + Oncometabolic role of mitochondrial sirtuins in glioma patients. + + e0281840 + + 10.1371/journal.pone.0281840 + + Mitochondrial sirtuins have diverse role specifically in aging, metabolism and cancer. In cancer, these sirtuins play dichotomous role as tumor suppressor and promoter. Previous studies have reported the involvement of sirtuins in different cancers. However, till now no study has been published with respect to mitochondrial sirtuins and glioma risks. Present study was purposed to figure out the expression level of mitochondrial sirtuins (SIRT3, SIRT4, SIRT5) and related genes (GDH, OGG1-2α, SOD1, SOD2, HIF1α and PARP1) in 153 glioma tissue samples and 200 brain tissue samples from epilepsy patients (taken as controls). To understand the role of selected situins in gliomagenesis, DNA damage was measured using the comet assay and oncometabolic role (oxidative stress level, ATP level and NAD level) was measured using the ELISA and quantitative PCR. Results analysis showed significant down-regulation of SIRT4 (p = 0.0337), SIRT5 (p<0.0001), GDH (p = 0.0305), OGG1-2α (p = 0.0001), SOD1 (p<0.0001) and SOD2 (p<0.0001) in glioma patients compared to controls. In case of SIRT3 (p = 0.0322), HIF1α (p = 0.0385) and PARP1 (p = 0.0203), significant up-regulation was observed. ROC curve analysis and cox regression analysis showed the good diagnostic and prognostic value of mitochondrial sirtuins in glioma patients. Oncometabolic rate assessment analysis showed significant increased ATP level (p<0.0001), NAD+ level [(NMNAT1 (p<0.0001), NMNAT3 (p<0.0001) and NAMPT (p<0.04)] and glutathione level (p<0.0001) in glioma patients compared to controls. Significant increased level of damage ((p<0.04) and decrease level of antioxidant enzymes include superoxide dismutase (SOD, p<0.0001), catalase (CAT, p<0.0001) and glutathione peroxidase (GPx, p<0.0001) was observed in patients compared to controls. Present study data suggest that variation in expression pattern of mitochondrial sirtuins and increased metabolic rate may have diagnostic and prognostic significance in glioma patients. + Copyright: © 2023 Haq et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Haq + Maria Fazal Ul + MFU + + Cancer Genetics and Epigenetics Research Group, Department of Biosciences, COMSATS University Islamabad, Islamabad, Pakistan. + + + + Hussain + Muhammad Zahid + MZ + + Department of Rheumatology, Military hospital, Rawalpindi, Pakistan. + + + + Mahjabeen + Ishrat + I + https://orcid.org/0000-0002-6392-672X + + Cancer Genetics and Epigenetics Research Group, Department of Biosciences, COMSATS University Islamabad, Islamabad, Pakistan. + + + + Akram + Zertashia + Z + + Cancer Genetics and Epigenetics Research Group, Department of Biosciences, COMSATS University Islamabad, Islamabad, Pakistan. + + + + Saeed + Nadia + N + + Cancer Genetics and Epigenetics Research Group, Department of Biosciences, COMSATS University Islamabad, Islamabad, Pakistan. + + + + Shafique + Rabia + R + + Cancer Genetics and Epigenetics Research Group, Department of Biosciences, COMSATS University Islamabad, Islamabad, Pakistan. + + + + Abbasi + Sumaira Fida + SF + + Cancer Genetics and Epigenetics Research Group, Department of Biosciences, COMSATS University Islamabad, Islamabad, Pakistan. + + + + Kayani + Mahmood Akhtar + MA + https://orcid.org/0000-0001-9886-180X + + Cancer Genetics and Epigenetics Research Group, Department of Biosciences, COMSATS University Islamabad, Islamabad, Pakistan. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 09 + 19 + + + 2023 + 01 + 31 + + + 2023 + 2 + 22 + 13 + 39 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809279 + 10.1371/journal.pone.0281840 + PONE-D-22-26011 + + +
+ + + 36809275 + + 2023 + 02 + 22 + +
+ + 1932-6203 + + 18 + 2 + + 2023 + + + PloS one + PLoS One + + Study protocol for cholera vaccination as a model to measure the inflammatory response in the gut: A case of modulation with a Lactobacillus plantarum K8 lysate. + + e0281817 + + 10.1371/journal.pone.0281817 + + It is crucial for human health that the immune system of the gastrointestinal tract works effectively. Dietary modulation is one of the factors that regulate the immune response in the gut. This study aims to develop a safe human challenge model to study gastrointestinal inflammation and immune function. This study focuses on evaluating gut stimulation induced by the oral cholera vaccine in healthy people. In addition, this paper describes the study design for assessing the efficacy and safety of a probiotic lysate, identifying whether functional ingredients in food can modulate inflammatory response induced by oral cholera vaccine. Forty-six males aged 20 to 50 with healthy bowel habits will be randomly allocated to the placebo or intervention group. Participants will consume 1 capsule of probiotic lysate or placebo twice daily for 6 weeks, take oral cholera vaccines on visit 2 (day 15) and visit 5 (day 29). The level of fecal calprotectin, a marker of gut inflammation, will be the primary outcome. The changes of cholera toxin-specific antibody levels and local/systemic inflammatory responses will be evaluated in blood. The purpose of this study is to evaluate gut stimulation of the oral cholera vaccine and investigate the effect of a probiotic lysate on improving the mild inflammatory response induced by the vaccine or supporting the immune response in healthy subjects. Trial registration: * This trial is registered in the International Clinical Trials Registry Platform of WHO (ICTRP, registration number: KCT0002589). + Copyright: © 2023 Park et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Park + Min Young + MY + + Department of Nutritional Science and Food Management, Ewha Womans University, Seoul, Republic of Korea. + + + + Park + Soo-Yeon + SY + + Department of Food Science and Technology, Seoul National University of Science and Technology, Seoul, Republic of Korea. + + + + Hartog + Anita + A + + Department of Health, NIZO, Ede, The Netherlands. + + + + van Hoffen + Els + E + + Department of Health, NIZO, Ede, The Netherlands. + + + + Kardinaal + Alwine + A + + Department of Health, NIZO, Ede, The Netherlands. + + + + Kim + Joohee + J + + BiofoodCRO Co., Ltd., Seoul, Republic of Korea. + + + + Choi + Hee Jung + HJ + + Division of Infectious Diseases, Office of Infection Control, Ewha Woman's University Medical Center, Seoul, Republic of Korea. + + + + Kwon + Oran + O + + Department of Nutritional Science and Food Management, Ewha Womans University, Seoul, Republic of Korea. + + + System Health & Engineering Major in Graduate School, Ewha Womans University, Seoul, Republic of Korea. + + + + Kim + Ji Yeon + JY + https://orcid.org/0000-0002-4316-2726 + + Department of Food Science and Technology, Seoul National University of Science and Technology, Seoul, Republic of Korea. + + + Department of Nutritional Science and Food Management, Graduate Program in System Health Science and Engineering, Ewha Womans University, Seoul, Republic of Korea. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 03 + 30 + + + 2023 + 01 + 20 + + + 2023 + 2 + 22 + 13 + 38 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809275 + 10.1371/journal.pone.0281817 + PONE-D-22-04882 + + +
+ + + 36809286 + + 2023 + 02 + 22 + +
+ + 1932-6203 + + 18 + 2 + + 2023 + + + PloS one + PLoS One + + Self-management of multiple long-term conditions: A systematic review of the barriers and facilitators amongst people experiencing socioeconomic deprivation. + + e0282036 + + 10.1371/journal.pone.0282036 + + Multiple long-term conditions are rising across all groups but people experiencing socioeconomic deprivation are found to have a higher prevalence. Self-management strategies are a vital part of healthcare for people with long-term conditions and effective strategies are associated with improved health outcomes in a variety of health conditions. The management of multiple long-term conditions are, however, less effective in people experiencing socioeconomic deprivation, leaving them more at risk of health inequalities. The purpose of this review is to identify and synthesise qualitative evidence on the barriers and facilitators of self-management on long-term conditions in those experiencing socioeconomic deprivation. + MEDLINE, EMBASE, AMED, PsycINFO and CINAHL Plus were searched for qualitative studies concerning self-management of multiple long-term conditions among socioeconomically disadvantaged populations. Data were coded and thematically synthesised using NVivo. + From the search results, 79 relevant qualitative studies were identified after the full text screening and 11 studies were included in the final thematic synthesis. Three overarching analytical themes were identified alongside a set of sub-themes: (1) Challenges of having multiple long-term conditions; prioritisation of conditions, impact of multiple long-term conditions on mental health and wellbeing, polypharmacy, (2) Socioeconomic barriers to self-management; financial, health literacy, compounding impact of multiple long-term conditions and socioeconomic deprivation, (3) Facilitators of self-management in people experiencing socioeconomic deprivation; maintaining independence, 'meaningful' activities, support networks. + Self-management of multiple long-term conditions is challenging for people experiencing socioeconomic deprivation due to barriers around financial constraints and health literacy, which can lead to poor mental health and wellbeing. To support targeted interventions, greater awareness is needed among health professionals of the barriers/challenges of self-management among these populations. + Copyright: © 2023 Woodward et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Woodward + Abi + A + https://orcid.org/0000-0001-6250-9070 + + Research Department of Primary Care and Population Health, University College London, London, United Kingdom. + + + + Davies + Nathan + N + https://orcid.org/0000-0001-7757-5353 + + Research Department of Primary Care and Population Health, University College London, London, United Kingdom. + + + + Walters + Kate + K + + Research Department of Primary Care and Population Health, University College London, London, United Kingdom. + + + + Nimmons + Danielle + D + + Research Department of Primary Care and Population Health, University College London, London, United Kingdom. + + + + Stevenson + Fiona + F + + Research Department of Primary Care and Population Health, University College London, London, United Kingdom. + + + + Protheroe + Joanne + J + https://orcid.org/0000-0002-9608-1487 + + School of Medicine, Keele University, Staffordshire, United Kingdom. + + + + Chew-Graham + Carolyn A + CA + + School of Medicine, Keele University, Staffordshire, United Kingdom. + + + + Armstrong + Megan + M + + Research Department of Primary Care and Population Health, University College London, London, United Kingdom. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 10 + 10 + + + 2023 + 02 + 06 + + + 2023 + 2 + 22 + 13 + 39 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809286 + 10.1371/journal.pone.0282036 + PONE-D-22-27698 + + +
+ + + 36809282 + + 2023 + 02 + 22 + +
+ + 1932-6203 + + 18 + 2 + + 2023 + + + PloS one + PLoS One + + A numerical simulation method for pressure drop and normal air velocity of pleated filters during dust loading. + + e0282026 + + 10.1371/journal.pone.0282026 + + Pressure drop is an important indicator that affects the filtration performance of the pleated filter, and the deposition of dust particles within the pleats is crucial to the evolution of the pressure drop. In this study, the pressure drop during PM10 loading process was investigated for a series of V-shaped and U-shaped filters with a pleat height of 20 mm and different pleat ratios (the ratio of pleat height to pleat width: α = 0.71-3.57). In the numerical simulations, numerical models suitable for different pleated geometries were obtained through experimental verification on the local air velocity. Then, assuming that the dust cake thickness is proportional to the normal air velocity of the filters, the variation of the pressure drop with the dust deposition is derived by means of successive numerical simulations. This simulation method saved a significant amount of CPU time required for the growth of dust cake. It was found that the relative average deviations between experimental and simulated pressure drops were 3.12% and 1.19% for V-shaped and U-shaped filters, respectively. Furthermore, it was found that under the same pleat ratio and the mass of dust deposition per unit area, both the pressure drop and unevenness of normal air velocity of the U-shaped filter were lower than the V-shaped filter. Therefore, the U-shaped filter is recommended due to its better filtration performance. + Copyright: © 2023 Teng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Teng + Guangping + G + + School of Safety Engineering, China University of Mining and Technology, Xuzhou, China. + + + School of Safety and Management Engineering, Hunan Institute of Technology, Hengyang, China. + + + + Shi + Guoqing + G + https://orcid.org/0000-0003-0915-8616 + + School of Safety Engineering, China University of Mining and Technology, Xuzhou, China. + + + State Key Laboratory of Coal Resources and Safe Mining, China University of Mining and Technology, Xuzhou, China. + + + + Zhu + Jintuo + J + + School of Safety Engineering, China University of Mining and Technology, Xuzhou, China. + + + + Qi + Jiamin + J + + School of Safety Engineering, China University of Mining and Technology, Xuzhou, China. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 09 + 15 + + + 2023 + 02 + 07 + + + 2023 + 2 + 22 + 13 + 39 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809282 + 10.1371/journal.pone.0282026 + PONE-D-22-25653 + + +
+ + + 36809278 + + 2023 + 02 + 22 + +
+ + 1932-6203 + + 18 + 2 + + 2023 + + + PloS one + PLoS One + + Encouraging brisk walking with the free Active10 app in postnatal women who had a hypertensive pregnancy: "Just Walk It" feasibility study. + + e0282066 + + 10.1371/journal.pone.0282066 + + To explore the feasibility of a future trial to investigate whether encouraging use of the free NHS smartphone app Active10 increases brisk walking and reduces blood pressure (BP) in postnatal mothers who had hypertensive disorders of pregnancy (HDP). + 3-month feasibility study. + London maternity unit. + 21 women with HDP. + At recruitment we recorded initial (booking) clinic BP and asked participants to complete a questionnaire. Two months after delivery all participants were sent (by post/email/WhatsApp) a "Just Walk It" leaflet encouraging them to download the Active10 app and walk briskly for at least 10 minutes/day. This was backed by a telephone call after 2-weeks. Assessments were repeated 3-months later, and included telephone interviews about the acceptability and use of Active10. + Were recruitment rate, follow-up rate and acceptability/use of Active10. + Of 28 women approached, 21 (75%, 95% CI 55.1-89.3%) agreed to participate. Age range was 21-46 years and five (24%) self-identified as black ethnicity. One woman dropped out of the study, and one became ill. The remaining participants (90%, 19/21, 95% CI 69.6-98.8%) were followed up after 3-months. Ninety-five percent (18/19) downloaded the Active10 app and 74% (14/19) continued using it at 3-months, averaging 27-minutes brisk walking/day according to Active10 weekly screenshots. Comments included: "Brilliant app", "Really motivates me". Mean BP was 130/81mmHg at booking and 124/80mmHg at 3-months follow-up. + The Active10 app was acceptable to postnatal women after HDP and may have increased minutes of brisk walking. A future trial could explore whether this simple, low-cost intervention could reduce long-term BP in this vulnerable group. + Copyright: © 2023 Razai et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Razai + Mohammad S + MS + https://orcid.org/0000-0002-6671-5557 + + Population Health Research Institute, St George's University of London, London, United Kingdom. + + + + Trinder + Bonnie + B + + St George's University Hospital NHS Trust, London, United Kingdom. + + + + Perry + Alice + A + + St George's University Hospital NHS Trust, London, United Kingdom. + + + + Cauldwell + Matthew + M + + St George's University Hospital NHS Trust, London, United Kingdom. + + + + Reid + Fiona + F + + Kings College London, London, United Kingdom. + + + + Oakeshott + Pippa + P + + Population Health Research Institute, St George's University of London, London, United Kingdom. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 03 + 05 + + + 2023 + 02 + 04 + + + 2023 + 2 + 22 + 13 + 39 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809278 + 10.1371/journal.pone.0282066 + PONE-D-22-06604 + + +
+ + + 36809276 + + 2023 + 02 + 22 + +
+ + 1537-4513 + + + 2023 + Feb + 22 + + + Journal of immunotherapy (Hagerstown, Md. : 1997) + J Immunother + + Elevated PD-L1 Expression and Microsatellite Instability in Elderly Patients With Gastric Cancer. + 10.1097/CJI.0000000000000458 + + Immunotherapy in combination with chemotherapy is the current treatment of choice for frontline programmed cell death ligand 1 (PD-L1)-positive gastric cancer. However, the best treatment strategy remains an unmet medical need for elderly or fragile patients with gastric cancer. Previous studies have revealed that PD-L1 expression, Epstein-Barr virus association, and microsatellite instability-high (MSI-H) are the potential predictive biomarkers for immunotherapy use in gastric cancer. In this study, we showed that PD-L1 expression, tumor mutation burden, and the proportion of MSI-H were significantly elevated in elderly patients with gastric cancer who were older than 70 years compared with patients younger than 70 years from analysis of The Cancer Genome Atlas gastric adenocarcinoma cohort [≥70/<70: MSI-H: 26.8%/15.0%, P=0.003; tumor mutation burden: 6.7/5.1 Mut/Mb, P=0.0004; PD-L1 mRNA: 5.6/3.9 counts per million mapped reads, P=0.005]. In our real-world study, 416 gastric cancer patients were analyzed and showed similar results (≥70/<70: MSI-H: 12.5%/6.6%, P=0.041; combined positive score ≥1: 38.1%/21.5%, P<0.001). We also evaluated 16 elderly patients with gastric cancer treated with immunotherapy and revealed an objective response of 43.8%, a median overall survival of 14.8 months, and a median progression-free survival of 7.0 months. Our research showed that a durable clinical response could be expected when treating elderly patients with gastric cancer with immunotherapy, and this approach is worth further study. + Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved. + + + + Chen + Tien-Hua + TH + + Division of Medical Oncology, Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan. + + + Department of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan. + + + + Chen + Ming-Huang + MH + + Division of Medical Oncology, Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan. + + + Department of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan. + + + Center for Immuno-Oncology, Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan. + + + + Hung + Yi-Ping + YP + + Division of Medical Oncology, Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan. + + + Department of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan. + + + Center for Immuno-Oncology, Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan. + + + + Chiang + Nai-Jung + NJ + + Division of Medical Oncology, Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan. + + + National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan. + + + + Huang + Kuo-Hung + KH + + Department of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan. + + + Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan. + + + + Lin + Yi-Hsiang + YH + + Institute of Biomedical Informatics, National Yang Ming Chiao Tung University, Taipei, Taiwan. + + + + Lin + Ryan Weihsiang + RW + + Institute of Biomedical Informatics, National Yang Ming Chiao Tung University, Taipei, Taiwan. + + + + Chao + Yee + Y + + Division of Medical Oncology, Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan. + + + Department of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan. + + + Center for Immuno-Oncology, Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan. + + + + Li + Anna Fen-Yau + AF + + Department of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan. + + + Department of Pathology, and Laboratory Medicine Taipei Veterans General Hospital, Taipei, Taiwan. + + + + Yu + Hung-Yuan + HY + + Department of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan. + + + Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan. + + + Hospitalist ward, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan. + + + + Hwang + Hsuen-En + HE + + Department of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan. + + + Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan. + + + + Yeh + Yi-Chen + YC + + Department of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan. + + + Institute of Biomedical Informatics, National Yang Ming Chiao Tung University, Taipei, Taiwan. + + + Department of Pathology, and Laboratory Medicine Taipei Veterans General Hospital, Taipei, Taiwan. + + + + Wang + Yu-Chao + YC + + Institute of Biomedical Informatics, National Yang Ming Chiao Tung University, Taipei, Taiwan. + + + + Fang + Wen-Liang + WL + + Department of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan. + + + Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan. + + + + eng + + Journal Article + + + 2023 + 02 + 22 + +
+ + United States + J Immunother + 9706083 + 1524-9557 + + IM +
+ + + + 2022 + 07 + 25 + + + 2023 + 01 + 25 + + + 2023 + 2 + 22 + 13 + 38 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809276 + 10.1097/CJI.0000000000000458 + 00002371-990000000-00042 + + + + Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68:394–424. + + + Etemadi A, Safiri S, Sepanlou SG, et al. The global, regional, and national burden of stomach cancer in 195 countries, 1990–2017: a systematic analysis for the Global Burden of Disease study 2017. Lancet Gastroenterol Hepatol. 2020;5:42–54. + + + Lin YT, Chiang CJ, Yang YW, et al. Secular decreasing trends in gastric cancer incidence in Taiwan: a population-based cancer registry study. World J Gastroenterol. 2021;27:5764–5774. + + + Shah SC, McKinley M, Gupta S, et al. Population-based analysis of differences in gastric cancer incidence among races and ethnicities in individuals age 50 years and older. Gastroenterology. 2020;159:1705–1714 e2. + + + Al-Batran SE, Hartmann JT, Probst S, et al. Phase III trial in metastatic gastroesophageal adenocarcinoma with fluorouracil, leucovorin plus either oxaliplatin or cisplatin: a study of the Arbeitsgemeinschaft Internistische Onkologie. J Clin Oncol. 2008;26:1435–1442. + + + Enzinger PC, Burtness BA, Niedzwiecki D, et al. CALGB 80403 (Alliance)/E1206: a randomized phase II study of three chemotherapy regimens plus cetuximab in metastatic esophageal and gastroesophageal junction cancers. J Clin Oncol. 2016;34:2736–2742. + + + Kim GM, Jeung HC, Rha SY, et al. A randomized phase II trial of S-1-oxaliplatin versus capecitabine-oxaliplatin in advanced gastric cancer. Eur J Cancer. 2012;48:518–526. + + + Lorenzen S, Schuster T, Porschen R, et al. Cetuximab plus cisplatin-5-fluorouracil versus cisplatin-5-fluorouracil alone in first-line metastatic squamous cell carcinoma of the esophagus: a randomized phase II study of the Arbeitsgemeinschaft Internistische Onkologie. Ann Oncol. 2009;20:1667–1673. + + + Janjigian YY, Shitara K, Moehler M, et al. First-line nivolumab plus chemotherapy versus chemotherapy alone for advanced gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma (CheckMate 649): a randomised, open-label, phase 3 trial. Lancet. 2021;398:27–40. + + + Fuchs CS, Doi T, Jang RW, et al. Safety and efficacy of pembrolizumab monotherapy in patients with previously treated advanced gstric and gastroesophageal junction cancer: phase 2 clinical KEYNOTE-059 trial. JAMA Oncol. 2018;4:e180013. + + + Chen LT, Satoh T, Ryu MH, et al. A phase 3 study of nivolumab in previously treated advanced gastric or gastroesophageal junction cancer (ATTRACTION-2): 2-year update data. Gastric Cancer. 2020;23:510–519. + + + Hall PS, Swinson D, Waters JS, et al. Optimizing chemotherapy for frail and elderly patients (pts) with advanced gastroesophageal cancer (aGOAC): the GO2 phase III trial. J Clin Oncol. 2019;37(suppl 15):4006–4006. + + + Thakkar JP, McCarthy BJ, Villano JL. Age-specific cancer incidence rates increase through the oldest age groups. Am J Med Sci. 2014;348:65–70. + + + Hall PS, Swinson D, Cairns DA, et al. Efficacy of reduced-intensity chemotherapy with oxaliplatin and capecitabine on quality of life and cancer control among older and frail patients with advanced gastroesophageal cancer: the GO2 phase 3 randomized clinical trial. JAMA Oncol. 2021;7:869–877. + + + Yu HY, Li CP, Huang YH, et al. Microsatellite instability, Epstein-Barr virus, and programmed cell death ligand 1 as predictive markers for immunotherapy in gastric cancer. Cancers (Basel). 2022;14:218. + + + Ellrott K, Bailey MH, Saksena G, et al. Scalable open science approach for mutation calling of tumor exomes using multiple genomic pipelines. Cell Syst. 2018;6:271–281. e7. + + + Cancer Genome Atlas Research N. Comprehensive molecular characterization of gastric adenocarcinoma. Nature. 2014;513:202–209. + + + Cerami E, Gao J, Dogrusoz U, et al. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2012;2:401–404. + + + Huang MN, McPherson JR, Cutcutache I, et al. MSIseq: software for assessing microsatellite instability from catalogs of somatic mutations. Sci Rep. 2015;5:13321. + + + Fang WL, Chang SC, Lan YT, et al. Microsatellite instability is associated with a better prognosis for gastric cancer patients after curative surgery. World J Surg. 2012;36:2131–2138. + + + Fang WL, Huang KH, Chang SC, et al. Comparison of the clinicopathological characteristics and genetic alterations between patients with gastric cancer with or without Helicobacter pylori infection. Oncologist. 2019;24:e845–e853. + + + Fang WL, Huang KH, Lan YT, et al. Mutations in PI3K/AKT pathway genes and amplifications of PIK3CA are associated with patterns of recurrence in gastric cancers. Oncotarget. 2016;7:6201–6220. + + + Erbe R, Wang Z, Wu S, et al. Evaluating the impact of age on immune checkpoint therapy biomarkers. Cell Rep. 2021;36:109599. + + + Rong L, Liu Y, Hui Z, et al. PD-L1 expression and its clinicopathological correlation in advanced esophageal squamous cell carcinoma in a Chinese population. Diagn Pathol. 2019;14:6. + + + Yu Z, Wang J, Feng L, et al. Association of tumor mutational burden with age in solid tumors. J Clin Oncol. 2020;38(15_suppl):e13590–e13590. doi: 10.1200/JCO.2020.38.15_suppl.e13590 + + 10.1200/JCO.2020.38.15_suppl.e13590 + + + + Shitara K, Van Cutsem E, Bang YJ, et al. Efficacy and safety of pembrolizumab or pembrolizumab plus chemotherapy vs chemotherapy alone for patients with first-line, advanced gastric cancer: the KEYNOTE-062 phase 3 randomized clinical trial. JAMA Oncol. 2020;6:1571–1580. + + + Davis AA, Patel VG. The role of PD-L1 expression as a predictive biomarker: an analysis of all US Food and Drug Administration (FDA) approvals of immune checkpoint inhibitors. J Immunother Cancer. 2019;7:278. + + + Xie T, Liu Y, Zhang Z, et al. Positive status of Epstein-Barr virus as a biomarker for gastric cancer immunotherapy: a prospective observational study. J Immunother. 2020;43:139–144. + + + Kim ST, Cristescu R, Bass AJ, et al. Comprehensive molecular characterization of clinical responses to PD-1 inhibition in metastatic gastric cancer. Nat Med. 2018;24:1449–1458. + + + Le DT, Kavan P, Kim TW, et al. KEYNOTE-164: Pembrolizumab for patients with advanced microsatellite instability high (MSI-H) colorectal cancer. J Clin Oncol. 2018;36(15_suppl):3514–3514. + + + Overman MJ, McDermott R, Leach JL, et al. Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study. Lancet Oncol. 2017;18:1182–1191. + + + Marabelle A, Fakih M, Lopez J, et al. Association of tumour mutational burden with outcomes in patients with advanced solid tumours treated with pembrolizumab: prospective biomarker analysis of the multicohort, open-label, phase 2 KEYNOTE-158 study. The Lancet Oncology. 2020;21:1353–1365. + + + Elias R, Giobbie-Hurder A, McCleary NJ, et al. Efficacy of PD-1 & PD-L1 inhibitors in older adults: a meta-analysis. J Immunother Cancer. 2018;6:26. + + + Jain V, Hwang WT, Venigalla S, et al. Association of age with efficacy of immunotherapy in metastatic melanoma. Oncologist. 2020;25:e381–e385. + + + Daste A, Domblides C, Gross-Goupil M, et al. Immune checkpoint inhibitors and elderly people: a review. Eur J Cancer. 2017;82:155–166. + + + +
+ + + 36809274 + + 2023 + 02 + 22 + +
+ + 2379-3708 + + + 2023 + Feb + 21 + + + JCI insight + JCI Insight + + Mapping the metabolic reprogramming induced by sodium-glucose cotransporter 2 inhibition. + 10.1172/jci.insight.164296 + e164296 + + Diabetes is associated with increased risk for kidney and liver diseases, congestive heart failure, and mortality. Urinary glucose excretion using sodium-glucose cotransporter 2 (SGLT2) inhibitors prevents these adverse outcomes. We performed in vivo metabolic labeling with 13C-glucose in normoglycemic and diabetic mice treated with or without the SGLT2 inhibitor dapagliflozin, followed by simultaneous metabolomics and metabolic flux analyses in different organs and the plasma. We found that in diabetes, glycolysis and glucose oxidation are impaired in the kidney, liver, and heart. Treatment with dapagliflozin failed to rescue glycolysis and further inhibited pyruvate kinase activity in the liver. SGLT2 inhibition increased glucose oxidation in all organs; in the kidney, this effect was associated with modulation of the redox state, which may protect against oxidative stress. In addition, diabetes was associated with altered methionine cycle metabolism, evident by decreased betaine and methionine levels, whereas treatment with SGLT2i increased hepatic betaine along with decreased homocysteine levels. mTORC1 activity was inhibited by SGLT2i along with stimulation of AMPK in both normoglycemic and diabetic animals, possibly explaining the protective effects against kidney, liver, and heart diseases. Collectively, our findings suggest that SGLT2i induces metabolic reprogramming orchestrated by AMPK-mTORC1 signaling with common and distinct effects in various tissues with implications for diabetes and aging. + + + + Kogot-Levin + Aviram + A + + Diabetes Unit and Endocrine Service, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. + + + + Riahi + Yael + Y + + Diabetes Unit and Endocrine Service, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. + + + + Abramovich + Ifat + I + + The Laboratory for Metabolism in Health and Disease, Technion-Israel Institute of Technology, Haifa, Israel. + + + + Mosenzon + Ofri + O + + Diabetes Unit and Endocrine Service, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. + + + + Agranovich + Bella + B + + The Laboratory for Metabolism in Health and Disease, Technion-Israel Institute of Technology, Haifa, Israel. + + + + Kadosh + Liat + L + + Diabetes Unit and Endocrine Service, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. + + + + Ben-Haroush Schyr + Rachel + R + + Developmental Biology and Cancer Research, Hadassah-Hebrew University Medical School, Jerusalem, Israel. + + + + Kleiman + Doron + D + + Developmental Biology and Cancer Research, Hadassah-Hebrew University Medical School, Jerusalem, Israel. + + + + Hinden + Liad + L + + The Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel. + + + + Cerasi + Erol + E + + Diabetes Unit and Endocrine Service, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. + + + + Ben-Zvi + Danny + D + + Developmental Biology and Cancer Research, Hadassah-Hebrew University Medical School, Jerusalem, Israel. + + + + Bernal-Mizrachi + Ernesto + E + + Department of Internal Medicine, The University of Miami Miller School of Medicine, Miami, United States of America. + + + + Tam + Joseph + J + + The Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel. + + + + Gottlieb + Eyal + E + + The Laboratory for Metabolism in Health and Disease, Technion-Israel Institute of Technology, Haifa, Israel. + + + + Leibowitz + Gil + G + + Hadassah-Hebrew University Medical Center, Jerusalem, Israel. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + JCI Insight + 101676073 + 2379-3708 + + IM + + Diabetes + Glucose metabolism + Metabolism + Signal transduction + Therapeutics + +
+ + + + 2023 + 2 + 22 + 13 + 38 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809274 + 164296 + 10.1172/jci.insight.164296 + + +
+ + + 36809284 + + 2023 + 02 + 22 + +
+ + 1527-6473 + + + 2023 + Jan + 03 + + + Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society + Liver Transpl + + Efficacy and safety of adhesion barrier in living-donor liver transplantation with right liver graft to prevent delayed gastric emptying. + 10.1097/LVT.0000000000000056 + + Delayed gastric emptying (DGE) is a common complication of liver transplantation. This study aimed to clarify the efficacy and safety of the application of an adhesion barrier for preventing DGE in living-donor liver transplantation. This retrospective study included 453 patients who underwent living-donor liver transplantation using a right lobe graft between January 2018 and August 2019, and the incidence of postoperative DGE and complications was compared between patients in whom adhesion barrier was used (n=179 patients) and those in whom adhesion barrier was not used (n=274 patients). We performed 1:1 propensity score matching between the 2 groups, and 179 patients were included in each group. DGE was defined according to the International Study Group for Pancreatic Surgery classification. The use of adhesion barrier was significantly associated with a lower overall incidence of postoperative DGE in liver transplantation (30.7 vs. 17.9%; p=0.002), including grades A (16.8 vs. 9.5%; p=0.03), B (7.3 vs. 3.4%; p=0.08), and C (6.6 vs. 5.5%; p=0.50). After propensity score matching, similar results were observed for the overall incidence of DGE (29.6 vs. 17.9%; p=0.009), including grades A (16.8 vs. 9.5%; p=0.04), B (6.7 vs. 3.4%; p=0.15), and C (6.1 vs. 5.0%; p=0.65). Univariate and multivariate analyses showed a significant correlation between the use of adhesion barrier and a low incidence of DGE. There were no statistically significant differences in postoperative complications between the 2 groups. The application of an adhesion barrier could be a safe and feasible method to reduce the incidence of postoperative DGE in living-donor liver transplantation. + Copyright © 2023 American Association for the Study of Liver Diseases. + + + + Kim + Sang-Hoon + SH + 0000-0002-8025-1816 + + Department of Surgery, Division of Liver Transplantation and Hepatobiliary Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. + + + + Lee + Sung-Gyu + SG + 0000-0001-9161-3491 + + + Hwang + Shin + S + 0000-0002-9045-2531 + + + Ahn + Chul-Soo + CS + 0000-0002-3844-3646 + + + Kim + Ki-Hun + KH + 0000-0002-4016-0995 + + + Moon + Deok-Bog + DB + 0000-0002-8209-3540 + + + Ha + Tea-Yong + TY + 0000-0001-9932-0212 + + + Song + Gi-Won + GW + 0000-0002-4235-0434 + + + Park + Gil-Chun + GC + 0000-0003-1631-3258 + + + Yoon + Young-In + YI + 0000-0002-9308-0366 + + + Kang + Woo-Hyoung + WH + 0000-0002-3734-3352 + + + Cho + Hwui-Dong + HD + 0000-0001-8501-3385 + + + Ha + Su-Min + SM + 0000-0001-7071-4963 + + + Na + Byeong-Gon + BG + 0000-0002-3150-4645 + + + Kim + Minjae + M + 0000-0001-6743-0636 + + + Kim + Sung-Min + SM + 0000-0003-2079-6141 + + + Yang + Geunhyeok + G + 0000-0002-8260-1525 + + + Oh + Rak-Kyun + RK + 0000-0002-6027-9432 + + + Jung + Dong-Hwan + DH + 0000-0001-5984-023 + + + eng + + Journal Article + + + 2023 + 01 + 03 + +
+ + United States + Liver Transpl + 100909185 + 1527-6465 + + IM +
+ + + + 2022 + 05 + 29 + + + 2022 + 10 + 31 + + + 2023 + 2 + 22 + 13 + 39 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809284 + 10.1097/LVT.0000000000000056 + 01445473-990000000-00055 + + + + Yoshida H, Mamada Y, Taniai N, Mizuguchi Y, Shimizu T, Kakinuma D, et al. Fixation of the greater omentum for prevention of delayed gastric emptying after left hepatectomy with lymphadenectomy for cholangiocarcinoma. J Hepatobiliary Pancreat Surg. 2007;14:392–6. + + + Navas CM, Wadas ED, Zbib NH, Crowell MD, Lacy BE. Gastroparesis and severity of delayed gastric emptying: comparison of patient characteristics, treatments and medication adverse events. Dig Dis Sci. 2021;66:526–34. + + + Wang H, Griesemer AD, Parsons RF, Graham JA, Emond JC, Samstein B. Delayed gastric emptying after living donor hepatectomy for liver transplantation. Case Rep Transplant. 2014;2014:1–5. + + + Oida T, Mimatsu K, Kawasaki A, Kanou H, Kuboi Y, Amano S. Fixation of the round ligament to the peritoneum and wrapping of the cut surface of the liver for prevention of early delayed gastric emptying after hepatic lateral segmentectomy. Langenbeck’s Arch Surg. 2010;395:655–9. + + + Okano K, Asano E, Oshima M, Yamamoto N, Yachida S, Nishizawa Y, et al. Omental flap wrapping with fixation to the cut surface of the liver for reducing delayed gastric emptying after left-sided hepatectomy. Surg Today. 2013;43:1425–32. + + + Okubo S, Shindoh J, Kobayashi Y, Hashimoto M. Safety of bioabsorbable membrane (Seprafilim®) in hepatectomy in the era of aggressive liver surgery. HPB. 2021;23:528–32. + + + Takatsuki M, Hidaka M, Natsuda K, Adachi T, Ono S, Hamada T, et al. Prevention of delayed gastric emptying after living donor left hepatectomy. Asian J Surg. 2021;44:1274–7. + + + Takagi K, Umeda Y, Yoshida R, Watanabe N, Kuise T, Yoshida K, et al. Short-term and long-term outcomes in living donors for liver transplantation: Cohort study. Int J Surg. 2020;84:147–53. + + + Diamond MP, Burns EL, Accomando B, Mian S, Holmdahl L. Seprafilm® adhesion barrier: (2) a review of the clinical literature on intraabdominal use. Gynecol Surg. 2012;9:247–57. + + + Becker JM, Dayton MT, Fazio VW, Beck DE, Stryker SJ, Wexner SD, et al. Prevention of postoperative abdominal adhesions by a sodium hyaluronate-based bioresorbable membrane: a prospective, randomized, double-blind multicenter study. J Am Coll Surg. 1996;183:297–306. + + + Shimizu A, Hasegawa K, Masuda K, Omichi K, Miyata A, Kokudo N. Efficacy of hyaluronic acid/carboxymethyl cellulose-based bioresorbable membranes in reducing perihepatic adhesion formation: a prospective Cohort study. Dig Surg. 2018;35:95–103. + + + Klingler PJ, Floch NR, Seelig MH, Branton SA, Wolfe JT, Metzger PP. Seprafilm®-induced peritoneal inflammation: a previously unknown complication. Dis Colon Rectum. 1999;42:1639–42. + + + Braunwarth E, Primavesi F, Göbel G, Cardini B, Oberhuber R, Margreiter C, et al. Is bile leakage after hepatic resection associated with impaired long-term survival? Eur J Surg Oncol. 2019;45:1077–83. + + + Itoh S, Uchiyama H, Ikeda Y, Morita K, Harada N, Sugimachi K, et al. Post-hepatectomy refractory ascites in cirrhotic patients with hepatocellular carcinoma: risk factor analysis to overcome this problematic complication. Anticancer Res. 2017;37:1381–5. + + + Wente MN, Bassi C, Dervenis C, Fingerhut A, Gouma DJ, Izbicki JR, et al. Delayed gastric emptying (DGE) after pancreatic surgery: a suggested definition by the International Study Group of Pancreatic Surgery (ISGPS). Surgery. 2007;142:761–8. + + + Moon DB, Lee SG, Hwang S, Ahn CS, Kim KH, Ha TY, et al. Splenic devascularization can replace splenectomy during adult living donor liver transplantation—a historical cohort study. Transpl Int. 2019;32:535–45. + + + Moon DB, Lee SG, Hwang S, Kim KH, Ahn CS, Ha TY, et al. No-touch en bloc right lobe living-donor liver transplantation with inferior vena cava replacement for hepatocellular carcinoma close to retrohepatic inferior vena cava: Case report. Transplant Proc. 2013;45:3135–9. + + + Alicia JM, Teresa CH, Michele LP, Leah CS, William RJM. Guideline for Prevention of Surgical Site Infection, 1999. Am J Infect Control. 1999;27:134. + + + Koch M, Garden OJ, Padbury R, Rahbari NN, Adam R, Capussotti L, et al. Bile leakage after hepatobiliary and pancreatic surgery: a definition and grading of severity by the International Study Group of Liver Surgery. Surgery. 2011;149:680–8. + + + Park CS, Hwang S, Ahn CS, Kim KH, Moon DB, Ha TY, et al. A comparative study regarding the effect of an intraperitoneal anti-adhesive agent application in left-liver living donors. Korean J Hepato-Biliary-Pancreatic Surg. 2014;18:26–28. + + + Sugimachi K, Shirabe K, Tokunaga N, Akiho H, Taketomi A, Soejima Y, et al. Assessment of delayed gastric emptying after major hepatectomy using a 13C-acetic acid breath test. Surg Today. 2012;42:1046–50. + + + Igami T, Nishio H, Ebata T, Yokoyama Y, Sugawara G, Nagino M. Using the greater omental flap to cover the cut surface of the liver for prevention of delayed gastric emptying after left-sided hepatobiliary resection: a prospective randomized controlled trial. J Hepatobiliary Pancreat Sci. 2011;18:176–83. + + + Malleo G, Crippa S, Butturini G, Salvia R, Partelli S, Rossini R, et al. Delayed gastric emptying after pylorus-preserving pancreaticoduodenectomy: validation of International Study Group of Pancreatic Surgery classification and analysis of risk factors. HPB. 2010;12:610–8. + + + Kwon JH, Jung DH, Hwang S, Kim KH, Ahn CS, Moon DB, et al. Feasibility of modified endarterectomized aortic allograft for middle hepatic vein reconstruction in living donor liver transplantation: a retrospective cohort study. Int J Surg. 2021;94:106–24. + + + Hwang S, Jung DH, Ha TY, Ahn CS, Moon DB, Kim KH, et al. Usability of ringed polytetrafluoroethylene grafts for middle hepatic vein reconstruction during living donor liver transplantation. Liver Transplant. 2012;18:955–65. + + + Jung HK, Choung RS, Locke GR, Schleck CD, Zinsmeister AR, Szarka LA, et al. The incidence, prevalence, and outcomes of patients with gastroparesis in Olmsted County, Minnesota, From 1996 to 2006. Gastroenterology. 2009;136:1225–33. + + + Monés J, Carrió I, Calabuig R, Estorch M, Sainz S, Berná L, et al. Influence of the menstrual cycle and of menopause on the gastric emptying rate of solids in female volunteers. Eur J Nucl Med. 1993;20:600–2. + + + Arnold W, David HV, Leah H, Judith SG, Kimberly ME, Raymond V, et al. Gastrointestinal transit: the effect of the menstrual cycle. Gastroenterology. 1981;80:1497–500.. + + + Stanghellini V, Tosetti C, Paternico A, Barbara G, Morselli-Labate AM, Monetti N, et al. Risk indicators of delayed gastric emptying of solids in patients with functional dyspepsia. Gastroenterology. 1996;110:1036–42. + + + Kobayashi Y, Shindoh J, Okubo S, Tani K, Morito M, Igata Y, et al. Hyaluronic acid/carboxymethyl cellulose-based adhesion barrier reduces surgical difficulty and complication in repeat hepatectomy. Hpb. 2021;23:907–14. + + + Clavien PA, Barkun J, De Oliveira ML, Vauthey JN, Dindo D, Schulick RD, et al. The Clavien-Dindo classification of surgical complications: five-year experience. Ann Surg. 2009;250:187–96. + + + +
+ + + 36809287 + + 2023 + 02 + 22 + +
+ + 1538-9855 + + 48 + 2 + + 2023 Mar-Apr 01 + + + Nurse educator + Nurse Educ + + Using Classroom Response Systems to Create Next-Generation NCLEX Clinical Judgment Scenarios. + + 64 + + 10.1097/NNE.0000000000001281 + + + Thomas + Rebecca + R + 0000-0002-3427-4259 + + By Rebecca Thomas, DNP, RN, Brady Urquhart, MSN, RN, Lisbeth Emley, MSN, RN, and Bailey Mosley, MSN, RN, University of South Alabama College of Nursing, Mobile, rthomas@southalabama.edu. + + + + Urquhart + Brady + B + + + Emley + Lisbeth + L + + + Mosley + Bailey + B + + + eng + + Journal Article + + + 2022 + 08 + 03 + +
+ + United States + Nurse Educ + 7701902 + 0363-3624 + + The authors declare no conflicts of interest. +
+ + + + 2023 + 2 + 22 + 13 + 39 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809287 + 10.1097/NNE.0000000000001281 + 00006223-202303000-00002 + + +
+ + + 36809290 + + 2023 + 02 + 22 + +
+ + 1932-6203 + + 18 + 2 + + 2023 + + + PloS one + PLoS One + + Merlin tumor suppressor function is regulated by PIP2-mediated dimerization. + + e0281876 + + 10.1371/journal.pone.0281876 + + Neurofibromatosis Type 2 is an inherited disease characterized by Schwann cell tumors of cranial and peripheral nerves. The NF2 gene encodes Merlin, a member of the ERM family consisting of an N-terminal FERM domain, a central α-helical region, and a C-terminal domain. Changes in the intermolecular FERM-CTD interaction allow Merlin to transition between an open, FERM accessible conformation and a closed, FERM-inaccessible conformation, modulating Merlin activity. Merlin has been shown to dimerize, but the regulation and function Merlin dimerization is not clear. We used a nanobody based binding assay to show that Merlin dimerizes via a FERM-FERM interaction, orientated with each C-terminus close to each other. Patient derived and structural mutants show that dimerization controls interactions with specific binding partners, including HIPPO pathway components, and correlates with tumor suppressor activity. Gel filtration experiments showed that dimerization occurs after a PIP2 mediated transition from closed to open conformation monomers. This process requires the first 18 amino acids of the FERM domain and is inhibited by phosphorylation at serine 518. The discovery that active, open conformation Merlin is a dimer represents a new paradigm for Merlin function with implications for the development of therapies designed to compensate for Merlin loss. + Copyright: © 2023 Hennigan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Hennigan + Robert F + RF + https://orcid.org/0000-0002-7054-8384 + + Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, OH, United States of America. + + + + Thomson + Craig S + CS + + Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, OH, United States of America. + + + + Stachowski + Kye + K + https://orcid.org/0000-0003-2378-6651 + + Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, OH, United States of America. + + + + Nassar + Nicolas + N + + Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, OH, United States of America. + + + + Ratner + Nancy + N + + Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, OH, United States of America. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 10 + 24 + + + 2023 + 01 + 30 + + + 2023 + 2 + 22 + 13 + 39 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809290 + 10.1371/journal.pone.0281876 + PONE-D-22-27439 + + +
+ + + 36809294 + + 2023 + 02 + 22 + +
+ + 2561-326X + + + 2023 + Feb + 13 + + + JMIR formative research + JMIR Form Res + + Leveraging Mobile Phone Sensors, Machine Learning and Explainable Artificial Intelligence to Predict Imminent Same-Day Binge Drinking Events to Support Just-In-Time Adaptive Interventions: A Feasibility Study. + 10.2196/39862 + + Digital Just-In-Time Adaptive Interventions (JITAIs) can reduce binge drinking events (BDEs: consuming 4+/5+ drinks per occasion for women/men) in young adults, but need to be optimized for timing and content. Delivering just-in-time support messages in the hours prior to BDEs could improve intervention impact. + We determined the feasibility of developing a machine learning model to accurately predict future, that is, same-day, 1 to 6-hours prior BDEs using smartphone sensor data. We aimed to identify the most informative phone sensor features associated with BDEs on weekend and weekdays, respectively, to determine the key features that explain prediction model performance. + We collected phone sensor data from 75 young adults (ages 21-25; mean =22.4, SD=1.9) with risky drinking behavior who reported drinking behavior over 14 weeks. Participants in this secondary analysis were enrolled in a clinical trial. We developed machine learning models testing different algorithms (e.g., XGBoost, decision tree) to predict same-day BDEs (versus low-risk drinking events and non-drinking periods) using smartphone sensor data (e.g., accelerometer, GPS). We tested various "prediction distance" time windows (more proximal: 1-hour; to distant: 6-hour) from drinking onset. We also tested various analysis time windows (i.e., amount of data to be analyzed), ranging from 1 to 12 hours prior to drinking onset, because this determines the amount of data that needs to be stored on the phone to compute the model. Explainable AI (XAI) was used to explore interactions between the most informative phone sensor features contributing to BDEs. + The XGBoost model performed best in predicting imminent same-day BDE, with 95.0% accuracy on weekends and 94.3% accuracy on weekdays (F1 score = 0.95 and 0.94, respectively). This XGBoost model needed 12- and 9-hours of phone sensor data at 3- and 6- hours prediction distance from the onset of drinking, on weekends and weekdays, respectively, prior to predicting same-day BDEs. The most informative phone sensor features for BDE prediction were time (e.g., time of day) and GPS-derived, such as radius of gyration (an indicator of travel). Interactions among key features (e.g., time of day, GPS-derived features) contributed to prediction of same-day BDE. + We demonstrated the feasibility and potential use of smartphone sensor data and machine learning to accurately predict imminent (same-day) BDEs in young adults. The prediction model provides "windows of opportunity" and with the adoption of XAI, we identified "key contributing features" to trigger JITAI prior to the onset of BDEs, with the potential to reduce the likelihood of BDEs in young adults. + + + + + Bae + Sang Won + SW + + Stevens Institute of Technology, Human-Computer Interaction and Human-Centered AI Systems Lab. AI for Healthcare Lab, 1 Castle Point Terrace, Hoboken, US. + + + + Suffoletto + Brian + B + + Department of Emergency Medicine, Stanford University, Stanford, US. + + + + Zhang + Tongze + T + + Stevens Institute of Technology, Human-Computer Interaction and Human-Centered AI Systems Lab. AI for Healthcare Lab, 1 Castle Point Terrace, Hoboken, US. + + + + Chung + Tammy + T + + Institute for Health, Healthcare Policy and Aging Research, Rutgers University, Newark, US. + + + + Ozolcer + Melik + M + + Stevens Institute of Technology, Human-Computer Interaction and Human-Centered AI Systems Lab. AI for Healthcare Lab, 1 Castle Point Terrace, Hoboken, US. + + + + Islam + Mohammad Rahul + MR + + Stevens Institute of Technology, Human-Computer Interaction and Human-Centered AI Systems Lab. AI for Healthcare Lab, 1 Castle Point Terrace, Hoboken, US. + + + + Dey + Anind + A + + Information School, University of Washington, Seattle, US. + + + + eng + + Journal Article + + + 2023 + 02 + 13 + +
+ + Canada + JMIR Form Res + 101726394 + 2561-326X + +
+ + + + 2023 + 2 + 22 + 13 + 40 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809294 + 10.2196/39862 + + +
+ + + 36809293 + + 2023 + 02 + 22 + +
+ + 1950-6007 + + 158 + + 2023 + Feb + + + Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie + Biomed Pharmacother + + Celastrol: The new dawn in the treatment of vascular remodeling diseases. + + 114177 + + S0753-3322(22)01566-9 + 10.1016/j.biopha.2022.114177 + + Evidence is mounting that abnormal vascular remodeling leads to many cardiovascular diseases (CVDs). This suggests that vascular remodeling can be a crucial target for the prevention and treatment of CVDs. Recently, celastrol, an active ingredient of the broadly used Chinese herb Tripterygium wilfordii Hook F, has attracted extensive interest for its proven potential to improve vascular remodeling. Substantial evidence has shown that celastrol improves vascular remodeling by ameliorating inflammation, hyperproliferation, and migration of vascular smooth muscle cells, vascular calcification, endothelial dysfunction, extracellular matrix remodeling, and angiogenesis. Moreover, numerous reports have proven the positive effects of celastrol and its therapeutic promise in treating vascular remodeling diseases such as hypertension, atherosclerosis, and pulmonary artery hypertension. The present review summarizes and discusses the molecular mechanism of celastrol regulating vascular remodeling and provides preclinical proof for future clinical applications of celastrol. + Copyright © 2023. Published by Elsevier Masson SAS. + + + + Tan + Jun-Lan + JL + + Department of Respiratory Diseases, School of Medicine, Hunan University of Chinese Medicine, Changsha 410208, Hunan, China; Hunan Provincial Key Laboratory of Vascular Biology and Translational Medicine, Changsha 410208, Hunan, China. + + + + Yi + Jian + J + + The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410021, Hunan, China. + + + + Cao + Xian-Ya + XY + + Department of Respiratory Diseases, School of Medicine, Hunan University of Chinese Medicine, Changsha 410208, Hunan, China; Hunan Provincial Key Laboratory of Vascular Biology and Translational Medicine, Changsha 410208, Hunan, China. + + + + Wang + Fei-Ying + FY + + Department of Respiratory Diseases, School of Medicine, Hunan University of Chinese Medicine, Changsha 410208, Hunan, China; Hunan Provincial Key Laboratory of Vascular Biology and Translational Medicine, Changsha 410208, Hunan, China. + + + + Xie + Si-Lin + SL + + Department of Respiratory Diseases, School of Medicine, Hunan University of Chinese Medicine, Changsha 410208, Hunan, China; Hunan Provincial Key Laboratory of Vascular Biology and Translational Medicine, Changsha 410208, Hunan, China. + + + + Zhou + Ling-Ling + LL + + Department of Respiratory Diseases, School of Medicine, Hunan University of Chinese Medicine, Changsha 410208, Hunan, China; Hunan Provincial Key Laboratory of Vascular Biology and Translational Medicine, Changsha 410208, Hunan, China. + + + + Qin + Li + L + + Hunan Provincial Key Laboratory of Vascular Biology and Translational Medicine, Changsha 410208, Hunan, China; Laboratory of Stem Cell Regulation with Chinese Medicine and Its Application, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, Hunan, China. Electronic address: lqin@hnucm.edu.cn. + + + + Dai + Ai-Guo + AG + + Department of Respiratory Diseases, School of Medicine, Hunan University of Chinese Medicine, Changsha 410208, Hunan, China; Hunan Provincial Key Laboratory of Vascular Biology and Translational Medicine, Changsha 410208, Hunan, China; Department of Respiratory Medicine, The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410021, Hunan, China. Electronic address: daiaiguo@hnucm.edu.cn. + + + + eng + + Journal Article + Review + + + 2023 + 01 + 03 + +
+ + France + Biomed Pharmacother + 8213295 + 0753-3322 + + IM + + Cardiovascular diseases + Celastrol + Endothelial dysfunction + Vascular remodeling + Vascular smooth muscle cells + + Conflict of interest statement The authors declare that there are no conflicts of interest. +
+ + + + 2022 + 10 + 31 + + + 2022 + 12 + 16 + + + 2022 + 12 + 28 + + + 2023 + 2 + 22 + 13 + 40 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809293 + S0753-3322(22)01566-9 + 10.1016/j.biopha.2022.114177 + + +
+ + + 36809296 + + 2023 + 02 + 22 + +
+ + 2379-3708 + + + 2023 + Feb + 21 + + + JCI insight + JCI Insight + + Distinct stage-specific transcriptional states of B cells derived from human tonsillar tissue. + 10.1172/jci.insight.155199 + e155199 + + B cells within secondary lymphoid tissues (SLTs) encompass a diversity of activation states and multiple maturation processes that reflect antigen recognition and transition through the germinal center (GC) reaction, in which mature B cells differentiate into memory and antibody-secreting cells (ASCs). Here, utilizing single-cell RNA-seq, we identify a range of distinct activation and maturation states of tonsillar-derived B cells. In particular, we identify a previously uncharacterized CCL4/CCL3 chemokine-expressing B-cell population with an expression pattern consistent with BCR/CD40 activation. Furthermore, we present a computational method leveraging regulatory network inference and pseudotemporal modeling to identify upstream transcription factor modulation along a GC to ASC axis of transcriptional maturation. Our dataset provides valuable insight into diverse B-cell functional profiles and will be a useful resource for further studies into the B-cell immune compartment. + + + + Espinoza + Diego A + DA + + Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America. + + + + Le Coz + Carole + C + + Division of Immunology and Allergy, Children's Hospital of Philadelphia, Philadelphia, United States of America. + + + + Cruz Cabrera + Emylette + E + + Division of Immunology and Allergy, Children's Hospital of Philadelphia, Philadelphia, United States of America. + + + + Romberg + Neil + N + + Division of Immunology and Allergy, Children's Hospital of Philadelphia, Philadelphia, United States of America. + + + + Bar-Or + Amit + A + + Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America. + + + + Li + Rui + R + + Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + JCI Insight + 101676073 + 2379-3708 + + IM + + Bioinformatics + Cell Biology + Immunology + +
+ + + + 2023 + 2 + 22 + 13 + 40 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809296 + 155199 + 10.1172/jci.insight.155199 + + +
+ + + 36809304 + + 2023 + 02 + 22 + +
+ + 1531-698X + + + 2023 + Feb + 22 + + + Current opinion in pediatrics + Curr Opin Pediatr + + A global update of mpox (monkeypox) in children. + 10.1097/MOP.0000000000001232 + + Human mpox disease (formerly monkeypox) was first diagnosed in an infant in the Democratic Republic of the Congo in 1970. Mpox was rarely reported outside West and Central Africa until the global outbreak in May 2022. On 23 July 2022, the WHO declared mpox a public health emergency of international concern. These developments warrant a global update on pediatric mpox. + Mpox epidemiology in endemic African countries has changed from predominantly affecting children under 10 years to adults 20-40 years old. This shift also applies to the global outbreak, where 18-44-year-old adult men who have sex with men are disproportionately affected. Furthermore, the proportion of children affected in the global outbreak is less than 2%, while children under 18 years constitute nearly 40% of cases in African countries. The highest mortality rates remain among both children and adults in African countries. + Mpox epidemiology has shifted to adults and is affecting relatively few children in the current global outbreak. However, infants, immunocompromised children and African children are still at high risk of severe disease. Mpox vaccines and therapeutic interventions should be accessible to at-risk and affected children globally, especially to those living in endemic African countries. + Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved. + + + + Sam-Agudu + Nadia A + NA + + International Research Center of Excellence, Institute of Human Virology Nigeria, Abuja, Nigeria. + + + Division of Epidemiology and Prevention, Institute of Human Virology. + + + Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA. + + + Department of Paediatrics and Child Health, University of Cape Coast School of Medical Sciences, Cape Coast. + + + + Martyn-Dickens + Charles + C + + Paediatric Infectious Diseases Unit, Directorate of Child Health, Komfo Anokye Teaching Hospital, Kumasi, Ghana. + + + + Ewa + Atana U + AU + + Respiratory/Infectious Diseases Unit, Department of Paediatrics, University of Calabar and University of Calabar Teaching Hospital, Calabar, Nigeria. + + + + eng + + Journal Article + + + 2023 + 02 + 22 + +
+ + United States + Curr Opin Pediatr + 9000850 + 1040-8703 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 40 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809304 + 10.1097/MOP.0000000000001232 + 00008480-990000000-00074 + + + + World Health Organization. Mpox (monkeypox) 2022. Available at: https://www.who.int/health-topics/monkeypox#tab=tab_1. [Accessed 4 December 2022]. + + + World Health Organization WHO Director-General's statement at the press conference following IHR Emergency Committee regarding the multicountry outbreak of monkeypox – 23 July 2022. 2022; Geneva, Switzerland:World Health Organization, Available at: https://www.who.int/director-general/speeches/detail/who-director-general-s-statement-on-the-press-conference-following-IHR-emergency-committee-regarding-the-multi-country-outbreak-of-monkeypox--23-july-2022. [Accessed 26 November 2022]. + + + World Health Organization. WHO recommends new name for monkeypox disease 2022. Available at: https://www.who.int/news/item/28-11-2022-who-recommends-new-name-for-monkeypox-disease. [Accessed 22 November 2022]. + + + [No authors listed] Monkeypox in Africa: future health hazard or public health nuisance? Lancet 1987; 1:369. + + + Sklenovská N, Van Ranst M. Emergence of monkeypox as the most important orthopoxvirus infection in humans. Front Public Health 2018; 6:241. + + + World Health Organization The global eradication of smallpox: final report of the global commission for the certification of smallpox eradication. 1979; Geneva, Switzerland:WHO, Available at: https://apps.who.int/iris/bitstream/handle/10665/39253/a41438.pdf?sequence=1&isAllowed=y. [Accessed 26 November 2022]. + + + Bunge EM, Hoet B, Chen L, et al. The changing epidemiology of human monkeypox—a potential threat? A systematic review. PLoS Negl Trop Dis 2022; 16:e0010141. + + + Rimoin AW, Kisalu N, Kebela-Ilunga B, et al. Endemic human monkeypox, Democratic Republic of Congo, 2001–2004. Emerg Infect Dis J 2007; 13:934. + + + Huhn GD, Bauer AM, Yorita K, et al. Clinical characteristics of human monkeypox, and risk factors for severe disease. Clin Infect Dis 2005; 41:1742–1751. + + + Besombes C, Mbrenga F, Schaeffer L, et al. National monkeypox surveillance, Central African Republic, 2001–2021. Emerg Infect Dis 2022; 28:2435–2445. + + + Beeson AM, Haston J, McCormick DW, et al. Mpox in children and adolescents: epidemiology, clinical features, diagnosis, and management. Pediatrics 2022; 151:e2022060179. + + + World Health Organization. Monkeypox – Democratic Republic of the Congo 2020. Available at: https://www.who.int/emergencies/disease-outbreak-news/item/monkeypox-democratic-republic-of-the-congo [Accessed 14 December 2022]. + + + Africa Centres for Disease Control and Prevention. Outbreak brief 25: monkeypox in Africa Union Member States 2023. Available at: https://africacdc.org/wp-content/uploads/2023/01/AfricaCDC_MpoxBrief-25-4Jan22.docx.pdf [Accessed 20 January 2023]. + + + Nigeria Centre for Disease Control and Prevention. Update of Monkeypox in Nigeria, Week 43 2022. Available at: https://ncdc.gov.ng/themes/common/files/sitreps/c647ad12b2789fde6292a941932f0b39.pdf. [Accessed 15 December 2022]. + + + World Health Organization. 2022 mpox (monkeypox) outbreak: global trends 2022. Available at: https://worldhealthorg.shinyapps.io/mpx_global/#4_Africa_in_Focus. [Accessed 15 December 2022]. + + + Mileto D, Riva A, Cutrera M, et al. New challenges in human monkeypox outside Africa: a review and case report from Italy. Travel Med Infect Dis 2022; 49:102386. + + + Kava CM, Rohraff DM, Wallace B, et al. Epidemiologic features of the monkeypox outbreak and the public health response – United States, May 17–October 6, 2022. MMWR Morb Mortal Wkly Rep 2022; 71:1449–1456. + + + United States Centers for Disease Control and Prevention. Clinical Considerations for Mpox in Children and Adolescents 2022. Available at: https://www.cdc.gov/poxvirus/monkeypox/clinicians/pediatric.html. [Accessed 20 January 2023]. + + + Thornhill JP, Barkati S, Walmsley S, et al. Monkeypox virus infection in humans across 16 countries – April–June 2022. N Engl J Med 2022; 387:679–691. + + + Alakunle E, Moens U, Nchinda G, Okeke MI. Monkeypox virus in Nigeria: infection biology, epidemiology, and evolution. Viruses 2020; 12:1257. + + + Yinka-Ogunleye A, Aruna O, Dalhat M, et al. Outbreak of human monkeypox in Nigeria in 2017–18: a clinical and epidemiological report. Lancet Infect Dis 2019; 19:872–879. + + + Nigeria Centre for Disease Control and Prevention. National monkeypox public health response guidelines 2019. Available at: https://ncdc.gov.ng/themes/common/docs/protocols/96_1577798337.pdf. [Accessed 11 December 2022]. + + + Ogoina D, Iroezindu M, James HI, et al. Clinical course and outcome of human monkeypox in Nigeria. Clin Infect Dis 2020; 71:e210–e214. + + + Titanji BK, Tegomoh B, Nematollahi S, et al. Monkeypox: a contemporary review for healthcare professionals. Open Forum Infect Dis 2022; 9:ofac310. + + + United States Centers for Disease Control and Prevention. Measles (rubella): for healthcare professionals 2022. Available at: https://www.cdc.gov/measles/hcp/index.html. [Accessed 20 January 2023]. + + + United States Centers for Disease Control and Prevention. Chickenpox (varicella): For Healthcare Professionals 2022. Available at: https://www.cdc.gov/chickenpox/hcp/index.html#features. [Accessed 20 January 2023]. + + + United States Centers for Disease Control and Prevention. Molluscum contagiosum 2022. Available at: https://www.cdc.gov/poxvirus/molluscum-contagiosum/index.html. [Accessed 20 January 2023]. + + + Guerra AM, Orille E, Waseem M. Hand foot and mouth disease. 2022; Treasure Island, FL:StatPearls Publishing, Copyright© 2022, StatPearls Publishing LLC. + + + Jezek Z, Grab B, Szczeniowski MV, et al. Human monkeypox: secondary attack rates. Bull World Health Organ 1988; 66:465–470. + + + Rimoin AW, Mulembakani PM, Johnston SC, et al. Major increase in human monkeypox incidence 30 years after smallpox vaccination campaigns cease in the Democratic Republic of Congo. Proc Natl Acad Sci U S A 2010; 107:16262–16267. + + + World Health Organization. Vaccines and immunization for monkeypox: Interim guidance 2022 November 16. Available at: https://apps.who.int/iris/rest/bitstreams/1479264/retrieve. [Accessed 24 December 2022]. + + + World Health Organization. Background document for the SAGE October 2022 session on monkeypox vaccines 2022 November 16. Available at: https://apps.who.int/iris/bitstream/handle/10665/364528/WHO-MPX-Immunization-Background-2022.3-eng.pdf?sequence=1&isAllowed=y. [Accessed 24 December 2022]. + + + Sam-Agudu NA, Titanji BK, Okumu F, Pai M. The pandemic is following a very predictable and depressing pattern 2022 March. Available at: https://www.theatlantic.com/health/archive/2022/03/pandemic-global-south-disease-health-crisis/624179/. [Accessed 17 December 2022]. + + + Africa Centres for Disease Control and Prevention. The Republic of Korea to donate first batch of mpox vaccine to Africa 2022 November 29. Available at: https://africacdc.org/news-item/the-republic-of-korea-to-donate-first-batch-of-mpox-vaccine-to-africa/. [Accessed 24 December 2022]. + + + Saied AA, Dhawan M, Metwally AA, et al. Disease history, pathogenesis, diagnostics, and therapeutics for human monkeypox disease: a comprehensive review. Vaccines (Basel) 2022; 10:2091. + + + World Health Organization. Monkeypox treatment trial begins in the Democratic Republic of the Congo 2022 Oct 12. Available at: https://www.nih.gov/news-events/news-releases/monkeypox-treatment-trial-begins-democratic-republic-congo. [Accessed 19 December 2022]. + + + ClinicalTrials.gov. Tecovirimat for treatment of monkeypox virus 2022. Available at: https://clinicaltrials.gov/ct2/show/NCT05559099. [Accessed 19 December 2022]. + + + ClinicalTrials.gov. Study of tecovirimat for human monkeypox virus (STOMP) 2022. Available at: https://clinicaltrials.gov/ct2/show/NCT05534984. [Accessed 19 December 2022]. + + + ClinicalTrials.gov. Assessment of the efficacy and safety of tecovirimat in patients with monkeypox virus disease (UNITY 2022). Available at: https://clinicaltrials.gov/ct2/show/NCT05597735. [Accessed 19 December 2022]. + + + Mbrenga F, Nakouné E, Malaka C, et al. Tecovirimat for monkeypox in Central African Republic under expanded access. N Engl J Med 2022; 387:2294–2295. + + + +
+ + + 36809297 + + 2023 + 02 + 22 + +
+ + 2379-3708 + + + 2023 + Feb + 21 + + + JCI insight + JCI Insight + + Lipogenesis promotes mitochondrial fusion and maintains cancer stemness in human NSCLC. + 10.1172/jci.insight.158429 + e158429 + + Cancer stem-like cells (CSCs) are critically involved in cancer metastasis and chemoresistance, acting as one major obstacle in clinical practice. While accumulating studies have implicated the metabolic reprogramming of CSCs, mitochondrial dynamics in such cells remain poorly understood. Here we pinpointed OPA1high with mitochondrial fusion as a metabolic feature of human lung CSCs, licensing their stem-like properties. Specifically, human lung CSCs exerted enhanced lipogenesis, inducing OPA1 expression via transcription factor SPDEF. In consequence, OPA1high promoted mitochondrial fusion and stemness of CSCs. Such lipogenesishigh, SPDEFhigh, and OPA1high metabolic adaptions were verified with primary CSCs from lung cancer patients. Accordingly, blocking lipogenesis and mitochondrial fusion efficiently impeded CSC expansion and growth of lung cancer patient-derived organoids. Together, lipogenesis regulates mitochondrial dynamics via OPA1 for controlling CSCs in human lung cancer. + + + + Liu + Zhen + Z + + Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China. + + + + Lei + Jiaxin + J + + Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China. + + + + Wu + Tong + T + + Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China. + + + + Hu + Weijie + W + + Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China. + + + + Zheng + Ming + M + + Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China. + + + + Wang + Ying + Y + + Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China. + + + + Song + Jingdong + J + + National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China. + + + + Ruan + Hang + H + + Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China. + + + + Xu + Lin + L + + Department for Immunobiology, Zunyi Medical University, Zunyi, China. + + + + Ren + Tao + T + + Department of Respiratory Medicine, Shanghai Sixth People's Hospital, Shanghai, China. + + + + Xu + Wei + W + + Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China. + + + + Wen + Zhenke + Z + + Soochow University, Suzhou, China. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + JCI Insight + 101676073 + 2379-3708 + + IM + + Lung cancer + Mitochondria + Oncology + +
+ + + + 2023 + 2 + 22 + 13 + 40 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809297 + 158429 + 10.1172/jci.insight.158429 + + +
+ + + 36809301 + + 2023 + 02 + 22 + +
+ + 1365-2346 + + + 2023 + Feb + 22 + + + European journal of anaesthesiology + Eur J Anaesthesiol + + A randomised controlled trial for the effectiveness of an audiovisual device on anxiety and pain perception during a nerve block for chronic pain relief. + 10.1097/EJA.0000000000001809 + + + Wisman + Eva + E + + From the Spaarne Gasthuis Academy, Spaarne Gasthuis Hospital, Hoofddorp (EW, KJvS), Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, Amsterdam (SIBP) and Department of Anesthesiology, Spaarne Gasthuis Hospital, Hoofddorp, The Netherlands (RDHdB). + + + + Perry + Sander I B + SIB + + + de Boer + Remco D H + RDH + + + van Stralen + Karlijn J + KJ + + + eng + + Journal Article + + + 2023 + 02 + 22 + +
+ + England + Eur J Anaesthesiol + 8411711 + 0265-0215 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 40 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809301 + 10.1097/EJA.0000000000001809 + 00003643-990000000-00068 + + + + Valet M, Sprenger T, Boecker H, et al. Distraction modulates connectivity of the cingulo-frontal cortex and the midbrain during pain--an fMRI analysis. Pain 2004; 109:399–408. + + + Ploeg van der H. Validity of the zelf-beoordelings-vragenlijst (a Dutch version of the Spielberger State-Trait Anxiety Inventory). Ned Tijdschr Psychol 1982; 35:243–249. + + + Dings SJM, van Stralen KJ, Struben VMD, et al. Pain and anxiety during vasectomies while distracting patients with video glasses or virtual reality glasses. BJU Int 2021; 128:561–567. + + + Smith V, Warty RR, Kashyap R, et al. A randomised controlled trial to assess the feasibility of utilising virtual reality to facilitate analgesia during external cephalic version. Sci Rep 2020; 10:3141. + + + Fang AS, Movva L, Ahmed S, et al. Clinical efficacy, safety, and feasibility of using video glasses during interventional radiologic procedures: a randomized trial. J Vasc Interv Radiol 2016; 27:260–267. + + + Basak T, Demirtas A, Yorubulut SM. Virtual reality and distraction cards to reduce pain during intramuscular benzathine penicillin injection procedure in adults: a randomized controlled trial. J Adv Nurs 2021; 77:2511–2518. + + + Wong MS, Spiegel BMR, Gregory KD. Virtual reality reduces pain in laboring women: a randomized controlled trial. Am J Perinatol 2021; 38 (S01):e167–e172. + + + +
+ + + 36809291 + + 2023 + 02 + 22 + +
+ + 1535-4970 + + + 2023 + Feb + 21 + + + American journal of respiratory and critical care medicine + Am J Respir Crit Care Med + + Waxing and Waning Cysts and Nodules. + 10.1164/rccm.202109-2196IM + + + Zhang + Ting + T + 0000-0003-0035-0011 + + Peking Union Medical College Hospital, 34732, Pulmonary and Critical Care Medicine, Beijing, China. + + + + Peng + Min + M + + Peking Union Medical College Hospital, 34732, Pulmonary and Critical Care Medicine, Beijing, China. + + + + Chang + Xiaoyan + X + + Peking Union Medical College Hospital, 34732, Pathology, Beijing, China. + + + + Shi + Juhong + J + + Peking Union Medical College Hospital, 34732, Pulmonary and critical care medicine, Beijing, China; shijh@pumch.cn. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Am J Respir Crit Care Med + 9421642 + 1073-449X + + IM + + Pulmonary hemorrhage + vascular Ehlers-Danlos syndrome + +
+ + + + 2023 + 2 + 22 + 13 + 39 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809291 + 10.1164/rccm.202109-2196IM + + +
+ + + 36809295 + + 2023 + 02 + 22 + +
+ + 1744-6848 + + + 2023 + Feb + 21 + + + Soft matter + Soft Matter + + Amorphous entangled active matter. + 10.1039/d2sm01573k + + The design of amorphous entangled systems, specifically from soft and active materials, has the potential to open exciting new classes of active, shape-shifting, and task-capable 'smart' materials. However, the global emergent mechanics that arise from the local interactions of individual particles are not well understood. In this study, we examine the emergent properties of amorphous entangled systems in an in silico collection of u-shaped particles ("smarticles") and in living entangled aggregate of worm blobs (L. variegatus). In simulations, we examine how material properties change for a collective composed of smarticles as they undergo different forcing protocols. We compare three methods of controlling entanglement in the collective: external oscillations of the ensemble, sudden shape-changes of all individuals, and sustained internal oscillations of all individuals. We find that large-amplitude changes of the particle's shape using the shape-change procedure produce the largest average number of entanglements, with respect to the aspect ratio (l/w), thus improving the tensile strength of the collective. We demonstrate applications of these simulations by showing how the individual worm activity in a blob can be controlled through the ambient dissolved oxygen in water, leading to complex emergent properties of the living entangled collective, such as solid-like entanglement and tumbling. Our work reveals principles by which future shape-modulating, potentially soft robotic systems may dynamically alter their material properties, advancing our understanding of living entangled materials, while inspiring new classes of synthetic emergent super-materials. + + + + Savoie + William + W + + School of Physics, Georgia Institute of Technology, Atlanta, GA 30318, USA. + + + + Tuazon + Harry + H + http://orcid.org/0000-0001-8512-4325 + + School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30318, USA. daniel.goldman@physics.gatech.edu. + + + + Tiwari + Ishant + I + http://orcid.org/0000-0003-0250-757X + + School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30318, USA. daniel.goldman@physics.gatech.edu. + + + + Bhamla + M Saad + MS + http://orcid.org/0000-0002-9788-9920 + + School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30318, USA. daniel.goldman@physics.gatech.edu. + + + + Goldman + Daniel I + DI + + School of Physics, Georgia Institute of Technology, Atlanta, GA 30318, USA. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Soft Matter + 101295070 + 1744-683X + + IM +
+ + + + 2023 + 2 + 22 + 13 + 40 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809295 + 10.1039/d2sm01573k + + +
+ + + 36809292 + + 2023 + 02 + 22 + +
+ + 1932-6203 + + 18 + 2 + + 2023 + + + PloS one + PLoS One + + Evaluating the feasibility and efficacy of a home-based combined high intensity interval and moderate intensity training program for increasing physical activity among low-active adults: A randomized pilot trial. + + e0281985 + + 10.1371/journal.pone.0281985 + + High intensity interval training (HIIT), which includes short bursts of high-intensity physical activity (PA) followed by recovery, can increase PA by addressing time barriers and improving PA enjoyment. The purpose of this pilot study was to examine the feasibility and preliminary efficacy of a home-based HIIT intervention on PA. + Low active adults (n = 47) were randomly assigned to a home-based HIIT intervention or wait-list control lasting 12 weeks. Participants in the HIIT intervention received motivational phone sessions based on Self-Determination Theory and accessed a website that included workout instructions and videos demonstrating proper form. + The HIIT intervention appears feasible based on retention, recruitment, adherence to the counseling sessions, follow-up rates, and the consumer satisfaction survey. HIIT participants reported more minutes of vigorous intensity PA at six weeks relative to control (no differences at 12 weeks). HIIT participants reported higher levels of self-efficacy for PA, enjoyment of PA, outcome expectations related to PA, and positive engagement with PA than the control. + This study provides evidence for feasibility and possible efficacy of a home-based HIIT intervention for vigorous intensity PA; however, additional studies are needed with larger samples sizes to confirm efficacy of home-based HIIT interventions. + Clinical Trials Number: NCT03479177. + Copyright: © 2023 Lewis et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Lewis + Beth A + BA + https://orcid.org/0000-0002-6034-568X + + School of Kinesiology, University of Minnesota, Minneapolis, Minnesota, United States of America. + + + + Schuver + Katie + K + https://orcid.org/0000-0002-1830-987X + + School of Kinesiology, University of Minnesota, Minneapolis, Minnesota, United States of America. + + + + Dunsiger + Shira + S + + Center for Health Promotion and Health Equity, Brown University, Providence, Rhode Island, United States of America. + + + + eng + + + ClinicalTrials.gov + + NCT03479177 + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2021 + 08 + 23 + + + 2023 + 02 + 05 + + + 2023 + 2 + 22 + 13 + 40 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809292 + 10.1371/journal.pone.0281985 + PONE-D-21-25777 + + +
+ + + 36809302 + + 2023 + 02 + 22 + +
+ + 1552-5783 + + 64 + 2 + + 2023 + Feb + 01 + + + Investigative ophthalmology & visual science + Invest Ophthalmol Vis Sci + + Choriocapillaris Flow Signal Impairment in Patients With Pseudoxanthoma Elasticum. + + 21 + + 10.1167/iovs.64.2.21 + + To quantify choriocapillaris flow alterations in patients with pseudoxanthoma elasticum (PXE) in pre-atrophic stages and its association with structural changes of the choroid and outer retina. + Thirty-two eyes of 21 patients with PXE and 35 healthy eyes of 35 controls were included. The density of choriocapillaris flow signal deficits (FDs) was quantified on 6 × 6-mm optical coherence tomography angiography (OCTA) images. Spectral-domain optical coherence tomography (SD-OCT) images were analyzed for thicknesses of the choroid and outer retinal microstructure and correlated with choriocapillaris FDs in the respective Early Treatment Diabetic Retinopathy Study subfield. + The multivariable mixed model analysis for choriocapillaris FDs revealed significantly higher FDs associated with the group (PXE patients vs. controls +13.6; 95% confidence interval [CI] 9.87-17.3; P < 0.001), with increasing age (+0.22% per year; 95% CI 0.12-0.33; P < 0.001), and with retinal location (significantly higher FDs in nasal compared to temporal subfields). Choroidal thickness (CT) did not differ significantly between both groups (P = 0.078). The CT and choriocapillaris FDs were inversely correlated (-1.92 µm per %FDs; interquartile range -2.81 to -1.03; P < 0.001). Larger values of the choriocapillaris FDs were associated with significant thinning of the overlying photoreceptor layers (outer segments: -0.21 µm per %FDs, P < 0.001; inner segments: -0.12 µm per %FDs, P = 0.001; outer nuclear layer: -0.72 µm per %FDs; P < 0.001). + Patients with PXE display significant alterations of the choriocapillaris on OCTA even in pre-atrophic stages and in the absence of significant choroidal thinning. The analysis favors choriocapillaris FDs over choroidal thickness as a potential early outcome measure for future interventional trials in PXE. Further, increased FDs in nasal compared to temporal locations mirror the centrifugal spread of Bruch's membrane calcification in PXE. + + + + Loewinger + Anne-Sophie + AS + + Department of Ophthalmology, University Hospital Bonn, Bonn, Germany. + + + + Pfau + Maximilian + M + + Department of Ophthalmology, University Hospital Bonn, Bonn, Germany. + + + Ophthalmic Genetics and Visual Function Branch, National Eye Institute, Bethesda, Maryland, United States. + + + + Herrmann + Philipp + P + + Department of Ophthalmology, University Hospital Bonn, Bonn, Germany. + + + + Holz + Frank G + FG + + Department of Ophthalmology, University Hospital Bonn, Bonn, Germany. + + + + Pfau + Kristina + K + + Department of Ophthalmology, University Hospital Bonn, Bonn, Germany. + + + Division of Epidemiology and Clinical Applications, National Eye Institute, Bethesda, Maryland, United States. + + + + eng + + Journal Article + +
+ + United States + Invest Ophthalmol Vis Sci + 7703701 + 0146-0404 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 40 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809302 + 2785386 + 10.1167/iovs.64.2.21 + + +
+ + + 36809300 + + 2023 + 02 + 22 + +
+ + 1537-4513 + + + 2023 + Feb + 22 + + + Journal of immunotherapy (Hagerstown, Md. : 1997) + J Immunother + + Pembrolizumab-Induced Acral Vasculitis. + 10.1097/CJI.0000000000000457 + + Immune checkpoint inhibitors (ICIs) have emerged as groundbreaking new therapies for a variety of solid tumors. ICIs stimulate the host immune system to attack cancer cells. However, this nonspecific immune activation can cause autoimmunity across multiple organ systems-this is referred to as an immune-related adverse event. Vasculitis secondary to ICI administration is an extremely rare event seen in <1% of cases. We identified 2 cases of pembrolizumab-induced acral vasculitis at our institution. The first patient, with stage IV adenocarcinoma of the lung, developed antinuclear antibody-positive vasculitis 4 months after initiation of treatment with pembrolizumab. The second patient had stage IV oropharyngeal cancer and presented with acral vasculitis 7 months after starting pembrolizumab. Unfortunately, both cases resulted in dry gangrene and poor outcomes. Here, we discuss the incidence, pathophysiology, clinical features, treatment, and prognosis of patients with ICI-induced vasculitis with the intention of raising awareness about this rare and potentially fatal immune-related adverse event. Early diagnosis and discontinuation of ICIs are critical for improving clinical outcomes in this situation. + Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved. + + + + Yohannan + Binoy + B + + Division of Hematology/Oncology. + + + + Truly + Tate + T + + Department of Internal Medicine. + + + + Kala + Jaya + J + + Division of Renal Diseases and Hypertension, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX. + + + + Jafri + Syed Hasan + SH + + Division of Hematology/Oncology. + + + + eng + + Journal Article + + + 2023 + 02 + 22 + +
+ + United States + J Immunother + 9706083 + 1524-9557 + + IM +
+ + + + 2022 + 06 + 01 + + + 2023 + 01 + 25 + + + 2023 + 2 + 22 + 13 + 40 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809300 + 10.1097/CJI.0000000000000457 + 00002371-990000000-00041 + + + + Boland P, Heath J, Sandigursky S. Immune checkpoint inhibitors and vasculitis. Curr Opin Rheumatol. 2020;32:53–56. + + + Richter MD, Crowson C, Kottschade LA, et al. Rheumatic syndromes associated with immune checkpoint inhibitors: a single‐center cohort of sixty‐one patients. Arthritis Rheumatol. 2019;71:468–475. + + + Daste A, Domblides C, Gross-goupil M, et al. Immune checkpoint inhibitors and elderly people: a review. Eur J Cancer. 2017;82:155–166. + + + Martins F, Sofiya L, Sykiotis GP, et al. Adverse effects of immune-checkpoint inhibitors: epidemiology, management and surveillance. Nat Rev Clin Oncol. 2019;16:563–580. + + + Mikami T, Liaw B, Asada M, et al. Neuroimmunological adverse events associated with immune checkpoint inhibitor: a retrospective, pharmacovigilance study using FAERS database. J Neurooncol. 2021;152:135–144. + + + Daxini A, Cronin K, Sreih AG. Vasculitis associated with immune checkpoint inhibitors—a systematic review. Clin Rheumatol. 2018;37:2579–2584. + + + Salem JE, Manouchehri A, Moey M, et al. Cardiovascular toxicities associated with immune checkpoint inhibitors: an observational, retrospective, pharmacovigilance study. Lancet Oncol. 2018;19:1579–1589. + + + Zou W, Wolchok JD, Chen L. PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations. Sci Transl Med. 2016;8:328rv4. doi: 10.1126/scitranslmed.aad7118. + + 10.1126/scitranslmed.aad7118 + + + + Lee K, Kronbichler A, Pereira Vasconcelos D, et al. Genetic variants in antineutrophil cytoplasmic antibody-associated vasculitis: a Bayesian approach and systematic review. J Clin Med. 2019;8:266. + + + Schneider BJ, Naidoo J, Santomasso BD, et al. Management of immune-related adverse events in patients treated with immune checkpoint inhibitor therapy: ASCO guideline update. J Clin Oncol. 2021;39:4073–4126. + + + +
+ + + 36809303 + + 2023 + 02 + 22 + +
+ + 1552-5783 + + 64 + 2 + + 2023 + Feb + 01 + + + Investigative ophthalmology & visual science + Invest Ophthalmol Vis Sci + + Topical Decorin Reduces Corneal Inflammation and Imparts Neuroprotection in a Mouse Model of Benzalkonium Chloride-induced Corneal Neuropathy. + + 20 + + 10.1167/iovs.64.2.20 + + We evaluated the neuroprotective and immunomodulatory effects of topical decorin in a murine model of benzalkonium chloride (BAK)-induced corneal neuropathy. + Topical BAK (0.1%) was administered daily to both eyes of female C57BL/6J mice (n = 14) for 7 days. One group of mice received topical decorin (1.07 mg/mL) eye drops to one eye and saline (0.9%) to the contralateral eye; the other group received saline eye drops to both eyes. All eye drops were given three times daily over the experimental period. A control group (n = 8) received daily topical saline only, instead of BAK. Optical coherence tomography imaging was performed before (at day 0) and after (day 7) treatment to evaluate the central corneal thickness. Whole-mount immunofluorescence staining was performed to evaluate the density of corneal intraepithelial nerves and immune cells. + BAK-exposed eyes showed corneal epithelial thinning, infiltration of inflammatory macrophages and neutrophils, and a lower density of intraepithelial nerves. No change to the corneal stromal thickness or dendritic cell density was observed. After BAK exposure, decorin-treated eyes had a lower density of macrophages and less neutrophil infiltration and a higher nerve density than the saline-treated group. Contralateral eyes from the decorin-treated animals showed fewer macrophages and neutrophils relative to saline-treated animals. A negative correlation was found between corneal nerve density and macrophage or neutrophil density. + Topical decorin provides neuroprotective and anti-inflammatory effects in a chemical model of BAK-induced corneal neuropathy. The attenuation of corneal inflammation by decorin may contribute to decreasing corneal nerve degeneration induced by BAK. + + + + Wu + Mengliang + M + + Department of Optometry and Vision Sciences, The University of Melbourne, Parkville, Victoria, Australia. + + + + Downie + Laura E + LE + + Department of Optometry and Vision Sciences, The University of Melbourne, Parkville, Victoria, Australia. + + + + Hill + Lisa J + LJ + + School of Biomedical Sciences, Institute of Clinical Sciences, University of Birmingham, Birmingham, United Kingdom. + + + + Chinnery + Holly R + HR + + Department of Optometry and Vision Sciences, The University of Melbourne, Parkville, Victoria, Australia. + + + + eng + + Journal Article + +
+ + United States + Invest Ophthalmol Vis Sci + 7703701 + 0146-0404 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 40 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809303 + 2785387 + 10.1167/iovs.64.2.20 + + +
+ + + 36809305 + + 2023 + 02 + 22 + +
+ + 1365-2168 + + + 2023 + Feb + 21 + + + The British journal of surgery + Br J Surg + + Author response to: Comment on: A randomized clinical trial of isolated ambulatory phlebectomy versus saphenous thermal ablation with concomitant phlebectomy (SAPTAP Trial). + znad037 + 10.1093/bjs/znad037 + + + Scheerders + Eveline R Y + ERY + 0000-0002-1688-7107 + + Department of Dermatology, Erasmus Medical Centre, Rotterdam, the Netherlands. + + + + van den Bos + Renate R + RR + + Department of Dermatology, Erasmus Medical Centre, Rotterdam, the Netherlands. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Br J Surg + 0372553 + 0007-1323 + + IM +
+ + + + 2023 + 01 + 30 + + + 2023 + 02 + 01 + + + 2023 + 2 + 22 + 13 + 40 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809305 + 7049701 + 10.1093/bjs/znad037 + + +
+ + + 36809288 + + 2023 + 02 + 22 + +
+ + 1538-9855 + + 48 + 2 + + 2023 Mar-Apr 01 + + + Nurse educator + Nurse Educ + + Using Guided Learning Templates to Practice Clinical Reasoning. + + 70 + + 10.1097/NNE.0000000000001282 + + + Eilts + Jennifer + J + + By Jennifer Eilts, MSN, RN, CNEn, Department of Nursing, Nebraska Wesleyan University, Lincoln, jeilts@nebrwesleyan.edu. + + + + eng + + Journal Article + + + 2022 + 08 + 03 + +
+ + United States + Nurse Educ + 7701902 + 0363-3624 + + The author declares no conflicts of interest. +
+ + + + 2023 + 2 + 22 + 13 + 39 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809288 + 10.1097/NNE.0000000000001282 + 00006223-202303000-00004 + + +
+ + + 36809289 + + 2023 + 02 + 22 + +
+ + 1538-9855 + + 48 + 2 + + 2023 Mar-Apr 01 + + + Nurse educator + Nurse Educ + + Competency-Based Education in Nursing: Getting Started With Program Evaluation. + + 108-109 + + 10.1097/NNE.0000000000001366 + + + Oermann + Marilyn H + MH + 0000-0002-4534-8962 + + Editor-in-Chief, Nurse Educator; Thelma M. Ingles Professor of Nursing, Duke University School of Nursing, Durham, North Carolina. + + + + eng + + Journal Article + +
+ + United States + Nurse Educ + 7701902 + 0363-3624 + + The author declares no conflicts of interest. +
+ + + + 2023 + 2 + 22 + 13 + 39 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809289 + 10.1097/NNE.0000000000001366 + 00006223-202303000-00016 + + + + American Association of Colleges of Nursing. The Essentials: Core Competencies for Professional Nursing Education. American Association of Colleges of Nursing; 2021. + + + Oermann MH. Some principles to guide assessment of competencies. Nurse Educ. 2022.47(1):1. doi:10.1097/NNE.0000000000001143 + + + Oermann MH. Program evaluation: what is it? In: Oermann MH, ed. A Systematic Approach to Evaluation of Nursing Programs. 2nd ed. National League for Nursing/Wolters Kluwer; 2023:1–9. + + + Van Melle E, Hall AK, Schumacher DJ, et al. Capturing outcomes of competency-based medical education: the call and the challenge. Med Teach. 2021;43(7):794–800. doi:10.1080/0142159X.2021.1925640 + + + +
+ + + 36809298 + + 2023 + 02 + 22 + +
+ + 1932-6203 + + 18 + 2 + + 2023 + + + PloS one + PLoS One + + Detailed chemical analysis of honey bee (Apis mellifera) worker brood volatile profile from egg to emergence. + + e0282120 + + 10.1371/journal.pone.0282120 + + Chemical communication is a widely used mode of communication for social insects and has been demonstrated to be involved in many behaviours and physiological processes such as reproduction, nutrition or the fight against parasites and pathogens. In the honey bee, Apis mellifera, the release of chemical compounds by the brood plays a role in worker behaviour, physiology, and foraging activities and colony health as a whole. Several compounds have already been described as brood pheromones, such as components of the brood ester pheromone and (E)-β-ocimene. Several other compounds originating from diseased or varroa-infested brood cells have been described as triggering the hygienic behaviour of workers. So far, studies of brood emissions have focused on specific stages of development and little is known about the emission of volatile organic compounds by the brood. In this study, we investigate the semiochemical profile of worker honey bee brood during its whole developmental cycle, from egg to emergence, with a specific focus on volatile organic compounds. We describe variation in emissions of thirty-two volatile organic compounds between brood stages. We highlight candidate compounds that are particularly abundant in specific stages and discuss their potential biological significance. + Copyright: © 2023 Noël et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Noël + Amélie + A + https://orcid.org/0000-0002-9737-4820 + + INRAE, UR 406 Abeilles et Environnement, Avignon, France. + + + + Dumas + Charlène + C + + INRAE, UR 406 Abeilles et Environnement, Avignon, France. + + + + Rottier + Emilien + E + + INRAE, UR 406 Abeilles et Environnement, Avignon, France. + + + + Beslay + Dominique + D + + INRAE, UR 406 Abeilles et Environnement, Avignon, France. + + + + Costagliola + Guy + G + + INRAE, UR 1115 Plantes et Systèmes de Culture Horticoles, Avignon, France. + + + + Ginies + Christian + C + + INRAE, UMR 408 Sécurité et Qualité des Produits d'Origine Végétale, Avignon, France. + + + + Nicolè + Florence + F + + Université de Lyon, UJM-Saint-Etienne, CNRS, LBVpam, Saint-Étienne, France. + + + + Rau + Andrea + A + https://orcid.org/0000-0001-6469-488X + + INRAE, UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France. + + + BioEcoAgro Joint Research Unit, INRAE, Université de Liège, Université de Lille, Université de Picardie Jules Verne, Estrées-Mons, France. + + + + Le Conte + Yves + Y + + INRAE, UR 406 Abeilles et Environnement, Avignon, France. + + + + Mondet + Fanny + F + + INRAE, UR 406 Abeilles et Environnement, Avignon, France. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 07 + 05 + + + 2023 + 02 + 07 + + + 2023 + 2 + 22 + 13 + 40 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809298 + 10.1371/journal.pone.0282120 + PONE-D-22-19029 + + +
+ + + 36809312 + + 2023 + 02 + 22 + +
+ + 1539-2864 + + + 2023 + Jan + 31 + + + Retina (Philadelphia, Pa.) + Retina + + Ultra-wide-field optical coherence tomography angiography in mild familial exudative vitreoretinopathy. + 10.1097/IAE.0000000000003754 + + To investigate ultra-wide-field optical coherence tomography angiography (UWF-OCTA) to detect and evaluate mild familial exudative vitreoretinopathy (FEVR) and compare the detective ratio of UWF-OCTA with ultra-wide-field scanning laser ophthalmoscopy (UWF-SLO) and ultra-wide-field fluorescein angiography (UWF-FA). + The patients with FEVR were included in this study. UWF-OCTA, using a 24 × 20 mm montage, was performed for all patients. All the images were independently tested for the presence of FEVR-associated lesions. Statistical analysis was performed with SPSS V.24.0. + Forty-six eyes of twenty-six participants were included in the study. UWF-OCTA was found to be greatly superior to UWF-SLO in detecting peripheral retinal vascular abnormality (p < 0.001) and peripheral retinal avascular zone (p < 0.001). The detection rates of peripheral retinal vascular abnormality, peripheral retinal avascular zone, retinal neovascularization, macular ectopia, and temporal mid-peripheral vitreoretinal interface abnormality were comparable with UWF-FA images (p > 0.05). Furthermore, vitreoretinal traction (17/46, 37%) and small foveal avascular zone (17/46, 37%) were detected effectively on UWF-OCTA. + UWF-OCTA is a reliable non-invasive tool to detect FEVR lesions, especially in mild patients or asymptomatic family members. The unique manifestation of UWF-OCTA offers an alternative to UWF-FA for the screening and diagnosis of FEVR. + + + + Wang + You + Y + + State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060, China. + + + + Lai + Yanting + Y + + + Zhou + Xiaodi + X + + + Zhang + Ting + T + + + Sun + Limei + L + + + Zhang + Zhaotian + Z + + + Huang + Li + L + + + Li + Songshan + S + + + Ding + Xiaoyan + X + + + eng + + Journal Article + + + 2023 + 01 + 31 + +
+ + United States + Retina + 8309919 + 0275-004X + + IM +
+ + + + 2023 + 2 + 22 + 13 + 41 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809312 + 10.1097/IAE.0000000000003754 + 00006982-990000000-00281 + + +
+ + + 36809314 + + 2023 + 02 + 22 + +
+ + 1538-0254 + + + 2023 + Feb + 21 + + + Journal of biomolecular structure & dynamics + J Biomol Struct Dyn + + Allosteric modulation of conserved motifs and helices in 5HT2BR: Advances drug discovery and therapeutic approach towards drug resistant epilepsy. + + 1-14 + + 10.1080/07391102.2023.2178508 + + The 5HT2BR, class-A GPCR is a new target, and its significance for seizure reduction in Dravet syndrome is just now gaining interest, suggesting its specific role in epileptic seizure management. Homology modeling of human 5HT2BR (P41595), was performed using a template 4IB4, the modeled structure was cross-validated (stereo chemical hindrance, Ramachandran plot, enrichment analysis) to mimic a closer native structure. Virtual screening (8532 compounds), drug-likeliness, mutagenicity, and carcinogenicity profiling prioritized six compounds for molecular dynamics (500 ns), Rgyr, DCCM. The receptor's C-alpha fluctuation upon bound agonist (6.91 Å), known antagonist (7.03 Å), and LAS 52115629 (5.83 Å) binding varies, leading to receptor stabilization. The residues C-alpha side-chain in active site strongly interacts (hydrogen bonds) with bound agonist (100% interaction: ASP135), known antagonist (95%:ASP135), and LAS 52115629 (100%:ASP135). The Rgyr for receptor-ligand complex, LAS 52115629 (25.68 Å), lies close to bound agonist-Ergotamine, and DCCM analysis also shows strong positive correlations for LAS 52115629 as compared to known drugs. LAS 52115629 is less likely to cause toxicity than known drugs. The structural parameters in the modeled receptor's conserved motifs (DRY, PIF, NPY) were altered for receptor activation upon ligand-binding, which otherwise was in the in-activated state. The ligand (LAS 52115629)-binding further alters the helices-III, V, VI (G-protein bound), and VII, which form potential interacting sites with the receptor and are proven necessary for activating the receptor. Therefore, LAS 52115629 can act as a potential 5HT2BR agonist, targeting drug-resistant epilepsy.Communicated by Ramaswamy H. Sarma. + + + + Chauhan + Arushi + A + 0000-0003-2653-1128 + + Department of Biophysics, Postgraduate Institute of Medical Education and Research, Chandigarh, India. + + + + Sangwan + Namrata + N + 0000-0001-8880-4641 + + Department of Biophysics, Postgraduate Institute of Medical Education and Research, Chandigarh, India. + + + + Singh + Jitender + J + 0000-0001-9716-2046 + + Department of Biophysics, Postgraduate Institute of Medical Education and Research, Chandigarh, India. + + + + Prakash + Ajay + A + 0000-0002-3487-8482 + + Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. + + + + Medhi + Bikash + B + 0000-0002-4017-641X + + Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. + + + + Avti + Pramod K + PK + 0000-0001-5603-4523 + + Department of Biophysics, Postgraduate Institute of Medical Education and Research, Chandigarh, India. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + J Biomol Struct Dyn + 8404176 + 0739-1102 + + IM + + 5HT2BR + Conserved motifs + G-Protein coupled receptor (GPCR) + molecular dynamics simulations + pharmaco-resistant epilepsy + +
+ + + + 2023 + 2 + 22 + 13 + 41 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809314 + 10.1080/07391102.2023.2178508 + + +
+ + + 36809316 + + 2023 + 02 + 22 + +
+ + 2162-2906 + + + 2023 + Feb + 21 + + + Journal of the Air & Waste Management Association (1995) + J Air Waste Manag Assoc + + Evaluating the feasibility of air environment management system for VOCs through 'VOCs specification' of petroleum refining industry. + 10.1080/10962247.2023.2182385 + + The chemical industry releases various types of volatile organic compounds (VOCs) into the atmosphere, and the concentration of VOCs emitted from chimneys is regulated worldwide. However, some VOCs such as benzene are highly carcinogenic, while others such as ethylene and propylene may cause secondary air pollution, owing to their high ozone-generating ability. Accordingly, the US EPA(United State, Environment Protect Agency) introduced a fenceline monitoring system that regulates the concentration of VOCs at the boundary of a facility, away from the chimney source. This system was first introduced in the petroleum refining industry, which simultaneously emits benzene, affecting the local community because of its high carcinogenicity, and ethylene, propylene, xylene, and toluene, which have a high photochemical ozone creation potential (POCP). These emissions contribute to air pollution. In Korea, the concentration at the chimney is regulated; however, the concentration at the plant boundary is not considered. In accordance with the EPA regulations, Korea's petroleum refining industries were identified and the limitations of the Clean Air Conservation Act were studied. The average concentration of benzene at the research facility examined in this study was 8.53 µg/m3, which complied with the benzene action level of 9 µg/m3. However, this value was exceeded at some points along the fenceline, in proximity to the benzene-toluene-xylene (BTX) manufacturing process. The composition ratios of toluene and xylene were 27% and 16%, respectively, which were higher than those of ethylene or propylene. These results suggest that reduction measures in the BTX manufacturing process are necessary. This study shows that legal regulations should enforce reduction measures through continuous monitoring at the fenceline of petroleum refineries in Korea. + + + + Kim + Min-Gyu + MG + + Department of Health and Safety Convergence Science, Korea University, Seongbuk-gu, Korea. + + + + Kim + Jeong Hun + JH + + Environmental Research Complex, National Institute of Environmental Research, Incheon, Korea. + + + + Yoon + Seok J + SJ + + Department of Health Science, Korea University, Seongbuk-gu, Korea. + + + + Cho + Sung Hwan + SH + + Environmental Research Complex, National Institute of Environmental Research, Incheon, Korea. + + + + Yu + Jeong Ung + JU + + Environmental Research Complex, National Institute of Environmental Research, Incheon, Korea. + + + + Kang + Cheon Woong + CW + + Environmental Research Complex, National Institute of Environmental Research, Incheon, Korea. + + + + Moon + Kyong Whan + KW + + Department of Health and Environmental Science, Korea University, Seong-buk-gu, Korea. + + + BK21 FOUR R&E Center for Learning Health System, Korea University, Seongbuk-gu, Korea. + + + + Lee + Hyo Eun + HE + 0000-0002-5707-1382 + + Department of Health Science, Korea University, Seongbuk-gu, Korea. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + J Air Waste Manag Assoc + 9503111 + 1096-2247 + + IM + + Fenceline monitoring + Photochemical ozone creation potential + VOC speciation + Volatile organic compound + petroleum refinery + +
+ + + + 2023 + 2 + 22 + 13 + 41 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809316 + 10.1080/10962247.2023.2182385 + + +
+ + + 36809315 + + 2023 + 02 + 22 + +
+ + 1619-3997 + + + 2023 + Feb + 23 + + + Journal of perinatal medicine + J Perinat Med + + Chorioangioma: a single tertiary care center retrospective study. + 10.1515/jpm-2021-0085 + + Chorioangioma represents a challenge due to the rarity of the condition, paucity of sufficient management guidelines, and controversies regarding the best invasive fetal therapy option; most of the scientific evidence for clinical treatment has been limited to case reports. The aim of this retrospective study was to review the natural antenatal history, maternal and fetal complications, and therapeutic modalities used in pregnancies complicated with placental chorioangioma at a single Center. + This retrospective study was conducted at King Faisal Specialist Hospital and Research Center (KFSH&RC) in Riyadh, Saudi Arabia. Our study population included all pregnancies with ultrasound features of chorioangioma, or histologically confirmed chorioangiomas, between January 2010 and December 2019. Data were collected from the patients' medical records, including the ultrasound reports and histopathology results. All subjects were kept anonymous; case numbers were used as identifiers. Data collected by the investigators were entered into Excel worksheets in an encrypted format. A MEDLINE database was used to retrieve 32 articles for literature review. + Over a 10-year period between January 2010 and December 2019, 11 cases of chorioangioma were identified. Ultrasound remains the gold standard for diagnosis and follow-up of the pregnancy. Seven of the 11 cases were detected by ultrasound, allowing proper fetal surveillance and antenatal follow-up. Of the remaining six patients, one underwent radiofrequency ablation, two underwent intrauterine transfusion for fetal anemia due to placenta chorioangioma, one had vascular embolization with an adhesive material, and two were managed conservatively until term with ultrasound surveillance. + Ultrasound remains the gold standard modality for prenatal diagnosis and follow-up of pregnancies with suspected chorioangiomas. Tumor size and vascularity play a significant role in the development of maternal-fetal complications and the success of fetal interventions. To determine the superior modality of fetal intervention mandates more data and research; nevertheless, Fetoscopic Laser Photocoagulation and embolization with adhesive material seem to be a lead choice, with reasonable fetal survival. + © 2023 Walter de Gruyter GmbH, Berlin/Boston. + + + + Saeed + Bashayer + B + + Department of Obstetrics & Gynecology, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia. + + + + Tulbah + Asma + A + + Department of Pathology & Laboratory Medicine, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia. + + + + Bintalib + Marwah + M + + Department of Obstetrics & Gynecology, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia. + + + + De Vol + Edward Bentz + EB + + Biostatistics, Epidemiology & Scientific Computing, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia. + + + + Almogbel + Samar + S + + Biostatistics, Epidemiology & Scientific Computing, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia. + + + + BaAli + Mawadah + M + + Biostatistics, Epidemiology & Scientific Computing, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia. + + + + Bukhari + Hanifa + H + + Department of Obstetrics & Gynecology, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia. + + + + Foudaneel + Meshayel + M + + Department of Obstetrics & Gynecology, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia. + + + + Almutairi + Jawaher + J + + Women & Infant Nursing, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia. + + + + Mahfodh + Maram Bin + MB + + College of Medicine, AlFaisal University, Riyadh, Saudi Arabia. + + + + Tulbah + Maha + M + + Department of Obstetrics & Gynecology, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia. + + + + Alnemer + Maha + M + + Department of Obstetrics & Gynecology, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia. + + + + Kurdi + Wesam + W + + Department of Obstetrics & Gynecology, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia. + + + + eng + + Journal Article + + + 2023 + 02 + 23 + +
+ + Germany + J Perinat Med + 0361031 + 0300-5577 + + IM + + chorioangioma + hydrops fetalis + maternal-fetal Doppler ultrasound + maternal-fetal medicine + placental tumors + prenatal diagnosis + +
+ + + + 2021 + 02 + 19 + + + 2022 + 11 + 16 + + + 2023 + 2 + 22 + 13 + 41 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809315 + jpm-2021-0085 + 10.1515/jpm-2021-0085 + + + + Fan, M, Skupski, DW. Placental chorioangioma: literature review. J Perinat Med 2014;42:273–9. https://doi.org/10.1515/jpm-2013-0170 . + + 10.1515/jpm-2013-0170 + + + + Resnik, R, Lockwood, CJ, Moore, T, Greene, MF, Copel, J, Silver, RM. Creasy and Resnik’s maternal-fetal medicine: principles and practice , 8th ed. Elsevier Health Sciences; 2018. Available from: https://www.us.elsevierhealth.com/creasy-and-resniks-maternal-fetal-medicine-principles-and-practice-9780323479103.html . + + + Sepulveda, W, Alcalde, JL, Schnapp, C, Bravo, M. Perinatal outcome after prenatal diagnosis of placental chorioangioma. Obstet Gynecol 2003;102:1028–33. https://doi.org/10.1097/00006250-200311000-00025 . + + 10.1097/00006250-200311000-00025 + + + + Liu, H, Gu, W, Li, X. Natural history and pregnancy outcome in patients with placental chorioangioma. J Clin Ultrasound 2014;42:74–80. https://doi.org/10.1002/jcu.22101 . + + 10.1002/jcu.22101 + + + + Taori, K, Patil, P, Attarde, V, Singh, A, Rangankar, V. Chorioangioma of placenta: sonographic features. J Clin Ultrasound 2008;36:113–5. https://doi.org/10.1002/jcu.20366 . + + 10.1002/jcu.20366 + + + + Shafqat, G, Iqbal, F, Rizvi, F. Chorioangioma of the placenta with hydrops foetalis. J Pak Med Assoc 2009;59:411–2. + + + Escribano, D, Galindo, A, Arbués, J, Puente, JM, De la Fuente, P. Prenatal management of placental chorioangioma: value of the middle placental artery peak systolic velocity. Fetal Diagn Ther 2006;21:489–93. https://doi.org/10.1159/000095659 . + + 10.1159/000095659 + + + + Ercan, CM, Coksuer, H, Karasahin, KE, Alanbay, I, Baser, I. Combined approach in a large placental chorioangioma case with intratumoral alcohol injection, cordocentesis, IU transfusion, and amnioreduction. 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+ + + 36809306 + + 2023 + 02 + 22 + +
+ + 1531-7013 + + + 2023 + Feb + 16 + + + Current opinion in organ transplantation + Curr Opin Organ Transplant + + Update on Covid-19: vaccines, timing of transplant after COVID-19 infection and use of positive donors. + 10.1097/MOT.0000000000001056 + + SARS-CoV-2 resulted in a global pandemic that had a chilling effect on transplantation early in the pandemic and continues to result in significant morbidity and mortality of transplant recipients. Over the past 2.5 years, our understanding of the clinical utility of vaccination and mAbs to prevent COVID-19 in solid organ transplant (SOT) recipients has been studied. Likewise, approach to donors and candidates with SARS-CoV-2 has been better understood. This review will attempt to summarize our current understanding of these important COVID-19 topics. + Vaccination against SARS-CoV-2 is effective in reducing the risk of severe disease and death among transplant patients. Unfortunately, humoral and, to a lesser extent, cellular immune response to existing COVID-19 vaccines is reduced in SOT recipients compared with healthy controls. Additional doses of vaccine are required to optimize protection of this population and still may be insufficient in those who are highly immunosuppressed, those receiving belatacept, rituximab and other B-cell active mAbs. Until recently, mAbs were options for the prevention of SARS-CoV-2 but are markedly less effective with recent omicron variants. SARS-CoV-2-infected donors can generally be used for nonlung, nonsmall bowel transplants unless they have died of acute severe COVID-19 or COVID-19-associated clotting disorders. + Our transplant recipients require a three-dose mRNA or adenovirus-vector and one dose of mRNA vaccine to be optimally protected initially; they then need to receive a bivalent booster 2+ months after completing their initial series. Most nonlung, nonsmall bowel donors with SARS-CoV-2 can be utilized as organ donors. + Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved. + + + + Boutin + Catherine-Audrey + CA + + Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois. + + + + Alamri + Maha + M + + Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois. + + + + Ison + Michael G + MG + + Respiratory Diseases Branch, Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. + + + + eng + + Journal Article + + + 2023 + 02 + 16 + +
+ + United States + Curr Opin Organ Transplant + 9717388 + 1087-2418 + + IM +
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+ + + 36809317 + + 2023 + 02 + 22 + +
+ + 1538-3598 + + 329 + 7 + + 2023 + Feb + 21 + + + JAMA + JAMA + + JAMA. + + 525-526 + + 10.1001/jama.2022.15799 + eng + + Journal Article + +
+ + United States + JAMA + 7501160 + 0098-7484 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 41 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809317 + 2801672 + 10.1001/jama.2022.15799 + + +
+ + + 36809313 + + 2023 + 02 + 22 + +
+ + 1758-5368 + + + 2023 + Feb + 21 + + + The journals of gerontology. Series B, Psychological sciences and social sciences + J Gerontol B Psychol Sci Soc Sci + + A Phenomenological Understanding of the Intersectionality of Ageism and Racism Among Older Adults: Individual-Level Experiences. + gbad031 + 10.1093/geronb/gbad031 + + Ageism is a prevalent, insidious social justice issue which has harmful effects on the health of older adults. Preliminary literature explores the intersectionality of ageism with sexism, ableism, and ageism experienced among LGBTQ+ older adults. Yet, the intersectionality of ageism with racism remains largely absent from the literature. Therefore, this study explores the lived experience of the intersectionality of ageism and racism among older adults. + This qualitative study applied a phenomenological approach. Twenty participants 60+ years of age (M=69) in the U.S. Mountain West identifying as Black, Latino(a), Asian-American/Pacific Islander, Indigenous, or White engaged in a one-hour interview between February and July 2021. A three-cycle coding process applied constant comparison methods. Five coders independently coded interviews, engaging in critical discussion to resolve disagreements. An audit trail, member checking, and peer debriefing enhanced credibility. + This study focuses on individual-level experiences exemplified by four umbrella themes and nine sub-themes. The umbrella themes are: 1) racism experienced differently based on age, 2) ageism experienced differently based on race, 3) comparing/contrasting experiences of ageism and racism, and 4) "othering" or discrimination. + The findings indicate how ageism may be racialized through stereotypes such as mental incapability. Practitioners can apply the findings to enhance support for older adults by designing interventions aimed at reducing racialized ageist stereotypes and increasing collaboration through education across anti-ageism/anti-racism initiatives. Future research should focus on the impacts of the intersectionality of ageism and racism on specific health outcomes in addition to structural-level interventions. + © The Author(s) 2023. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. + + + + Steward + Andrew + A + 0000-0001-8372-1871 + + Assistant Professor, University of Wisconsin-Milwaukee Helen Bader School of Social Welfare. + + + + De Fries + Carson M + CM + 0000-0002-4086-399X + + University of Denver Graduate School of Social Work. + + + + Dunbar + Annie Zean + AZ + + University of Denver Graduate School of Social Work. + + + + Trujillo + Miguel + M + + University of Denver Graduate School of Social Work. + + + + Zhu + Yating + Y + + University of Denver Morgridge College of Education. + + + + Nicotera + Nicole + N + + University of Denver Graduate School of Social Work. + + + + Hasche + Leslie + L + + University of Denver Graduate School of Social Work. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + J Gerontol B Psychol Sci Soc Sci + 9508483 + 1079-5014 + + IM + + ageism + intersectionality + phenomenology + racism + +
+ + + + 2022 + 08 + 23 + + + 2023 + 2 + 22 + 13 + 41 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809313 + 7049937 + 10.1093/geronb/gbad031 + + +
+ + + 36809309 + + 2023 + 02 + 22 + +
+ + 1477-0539 + + + 2023 + Feb + 21 + + + Organic & biomolecular chemistry + Org Biomol Chem + + Aniline assisted dimerization of phenylalanines: convenient synthesis of 2-aroyl-3-arylquinoline in an I2-DMSO system. + 10.1039/d2ob02283d + + We herein report an efficient synthesis of 2-aroyl-3-arylquinolines from phenylalanines and anilines. The mechanism involves I2-mediated Strecker degradation enabled catabolism and reconstruction of amino acids and a cascade aniline-assisted annulation. Both DMSO and water act as oxygen sources in this convenient protocol. + + + + Ma + Jin-Tian + JT + + Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China. chwuax@mail.ccnu.edu.cn. + + + + Chen + Ting + T + + Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China. chwuax@mail.ccnu.edu.cn. + + + + Chen + Xiang-Long + XL + + Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China. chwuax@mail.ccnu.edu.cn. + + + + Zhou + You + Y + + Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China. chwuax@mail.ccnu.edu.cn. + + + + Yu + Zhi-Cheng + ZC + + Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China. chwuax@mail.ccnu.edu.cn. + + + + Zhuang + Shi-Yi + SY + + Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China. chwuax@mail.ccnu.edu.cn. + + + + Wu + Yan-Dong + YD + + Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China. chwuax@mail.ccnu.edu.cn. + + + + Xiang + Jia-Chen + JC + http://orcid.org/0000-0003-2422-6103 + + School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China. xiangjiachen@seu.edu.cn. + + + + Wu + An-Xin + AX + http://orcid.org/0000-0001-7673-210X + + Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China. chwuax@mail.ccnu.edu.cn. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Org Biomol Chem + 101154995 + 1477-0520 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 41 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809309 + 10.1039/d2ob02283d + + +
+ + + 36809307 + + 2023 + 02 + 22 + +
+ + 1365-2346 + + + 2023 + Feb + 22 + + + European journal of anaesthesiology + Eur J Anaesthesiol + + Variable ventilation versus stepwise lung recruitment manoeuvres for lung recruitment: A comparative study in an experimental model of atelectasis. + 10.1097/EJA.0000000000001808 + + Variable ventilation recruits alveoli in atelectatic lungs, but it is unknown how it compares with conventional recruitment manoeuvres. + To test whether mechanical ventilation with variable tidal volumes and conventional recruitment manoeuvres have comparable effects on lung function. + Randomised crossover study. + University hospital research facility. + Eleven juvenile mechanically ventilated pigs with atelectasis created by saline lung lavage. + Lung recruitment was performed using two strategies, both with an individualised optimal positive-end expiratory pressure (PEEP) associated with the best respiratory system elastance during a decremental PEEP trial: conventional recruitment manoeuvres (stepwise increase of PEEP) in pressure-controlled mode) followed by 50 min of volume-controlled ventilation (VCV) with constant tidal volume, and variable ventilation, consisting of 50 min of VCV with random variation in tidal volume. + Before and 50 min after each recruitment manoeuvre strategy, lung aeration was assessed by computed tomography, and relative lung perfusion and ventilation (0% = dorsal, 100% = ventral) were determined by electrical impedance tomography. + After 50 min, variable ventilation and stepwise recruitment manoeuvres decreased the relative mass of poorly and nonaerated lung tissue (percent lung mass: 35.3 ± 6.2 versus 34.2 ± 6.6, P = 0.303); reduced poorly aerated lung mass compared with baseline (-3.5 ± 4.0%, P = 0.016, and -5.2 ± 2.8%, P < 0.001, respectively), and reduced nonaerated lung mass compared with baseline (-7.2 ± 2.5%, P < 0.001; and -4.7 ± 2.8%, P < 0.001 respectively), while the distribution of relative perfusion was barely affected (variable ventilation: -0.8 ± 1.1%, P = 0.044; stepwise recruitment manoeuvres: -0.4 ± 0.9%, P = 0.167). Compared with baseline, variable ventilation and stepwise recruitment manoeuvres increased PaO2 (172 ± 85mmHg, P = 0.001; and 213 ± 73 mmHg, P < 0.001, respectively), reduced PaCO2 (-9.6 ± 8.1 mmHg, P = 0.003; and -6.7 ± 4.6 mmHg, P < 0.001, respectively), and decreased elastance (-11.4 ± 6.3 cmH2O, P < 0.001; and -14.1 ± 3.3 cmH2O, P < 0.001, respectively). Mean arterial pressure decreased during stepwise recruitment manoeuvres (-24 ± 8 mmHg, P = 0.006), but not variable ventilation. + In this model of lung atelectasis, variable ventilation and stepwise recruitment manoeuvres effectively recruited lungs, but only variable ventilation did not adversely affect haemodynamics. + This study was registered and approved by Landesdirektion Dresden, Germany (DD24-5131/354/64). + Copyright © 2023 European Society of Anaesthesiology and Intensive Care. Unauthorized reproduction of this article is prohibited. + + + + Vivona + Luigi + L + + From the Department of Anesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany (LV, RH, AB, MS, JW, TK, PH, MH, MM, MGA, TB), Department of Pathophysiology and Transplantation, University of Milan, Italy (LV), Institute of Nuclear Medicine, University Hospital Carl Gustav Carus, Dresden (AB), Department of Anesthesiology, Elblandklinikum Radebeul, Radebeul (TK), Institute of Biomedical Engineering, Karlsruhe Institute of Technology (KIT), Karlsruhe (MK), Drägerwerk AG & Co KGaA, Lübeck, Germany (MK), IRCCS San Martino IST, Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy (MM), Department of Intensive Care and Resuscitation (MGA) and Department of Outcomes Research, Anesthesiology Institute, Cleveland Clinic, Cleveland, Ohio, USA (MGA). + + + + Huhle + Robert + R + + + Braune + Anja + A + + + Scharffenberg + Martin + M + + + Wittenstein + Jakob + J + + + Kiss + Thomas + T + + + Kircher + Michael + M + + + Herzog + Paul + P + + + Herzog + Moritz + M + + + Millone + Marco + M + + + Gama de Abreu + Marcelo + M + + + Bluth + Thomas + T + + + eng + + Journal Article + + + 2023 + 02 + 22 + +
+ + England + Eur J Anaesthesiol + 8411711 + 0265-0215 + + IM +
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Prevention and reversal of lung collapse during the intra-operative period. Best Pract Res Clin Anaesthesiol 2010; 24:183–197. + + + Cavalcanti AB, Suzumura ÉA, et al. Writing Group for the Alveolar Recruitment for Acute Respiratory Distress Syndrome Trial (ART) Investigators Effect of lung recruitment and titrated positive end-expiratory pressure (PEEP) vs low PEEP on mortality in patients with acute respiratory distress syndrome: a randomized clinical trial. JAMA 2017; 318:1335–1345. + + + Hanouz JL, Coquerel A, Persyn C, et al. Changes in stroke volume during an alveolar recruitment maneuvers through a stepwise increase in positive end expiratory pressure and transient continuous positive airway pressure in anesthetized patients. A prospective observational pilot study. J Anaesthesiol Clin Pharmacol 2019; 35:453–459. + + + Wittenstein J, Huhle R, Scharffenberg M, et al. Effects of two stepwise lung recruitment strategies on respiratory function and haemodynamics in anaesthetised pigs: a randomised crossover study. Eur J Anaesthesiol 2021; 38:634–643. + + + Lim S-C, Adams AB, Simonson DA, et al. Transient hemodynamic effects of recruitment maneuvers in three experimental models of acute lung injury. Crit Care Med 2004; 32:2378–2384. + + + Hemmes SNT, Gama de Abreu M, et al. PROVE Network Investigators for the Clinical Trial Network of the European Society of Anaesthesiology High versus low positive end-expiratory pressure during general anaesthesia for open abdominal surgery (PROVHILO trial): a multicentre randomised controlled trial. Lancet 2014; 384:495–503. + + + Bluth T, Serpa Neto A, et al. Writing Committee for the PROBESE Collaborative Group of the PROtective VEntilation Network (PROVEnet) for the Clinical Trial Network of the European Society of Anaesthesiology Effect of intraoperative high positive end-expiratory pressure (PEEP) with recruitment maneuvers vs low PEEP on postoperative pulmonary complications in obese patients: a randomized clinical trial. JAMA 2019; 321:2292–2305. + + + Lim S-C, Adams AB, Simonson DA, et al. Intercomparison of recruitment maneuver efficacy in three models of acute lung injury. Crit Care Med 2004; 32:2371–2377. + + + Samary CS, Moraes L, Santos CL, et al. Lung functional and biologic responses to variable ventilation in experimental pulmonary and extrapulmonary acute respiratory distress syndrome. Crit Care Med 2016; 44:e553–e562. + + + +
+ + + 36809310 + + 2023 + 02 + 22 + +
+ + 2471-254X + + 7 + 3 + + 2023 + Mar + 01 + + + Hepatology communications + Hepatol Commun + + Hepatic MCPIP1 protein levels are reduced in NAFLD patients and are predominantly expressed in cholangiocytes and liver endothelium. + + e0008 + + 10.1097/HC9.0000000000000008 + + NAFLD is characterized by the excessive accumulation of fat in hepatocytes. NAFLD can range from simple steatosis to the aggressive form called NASH, which is characterized by both fatty liver and liver inflammation. Without proper treatment, NAFLD may further progress to life-threatening complications, such as fibrosis, cirrhosis, or liver failure. Monocyte chemoattractant protein-induced protein 1 (MCPIP1, alias Regnase 1) is a negative regulator of inflammation, acting through the cleavage of transcripts coding for proinflammatory cytokines and the inhibition of NF-κB activity. + In this study, we investigated MCPIP1 expression in the liver and peripheral blood mononuclear cells (PBMCs) collected from a cohort of 36 control and NAFLD patients hospitalized due to bariatric surgery or primary inguinal hernia laparoscopic repair. Based on liver histology data (hematoxylin and eosin and Oil Red-O staining), 12 patients were classified into the NAFL group, 19 into the NASH group, and 5 into the control (non-NAFLD) group. Biochemical characterization of patient plasma was followed by expression analysis of genes regulating inflammation and lipid metabolism. The MCPIP1 protein level was reduced in the livers of NAFL and NASH patients in comparison to non-NAFLD control individuals. In addition, in all groups of patients, immunohistochemical staining showed that the expression of MCPIP1 was higher in the portal fields and bile ducts in comparison to the liver parenchyma and central vein. The liver MCPIP1 protein level negatively correlated with hepatic steatosis but not with patient body mass index or any other analyte. The MCPIP1 level in PBMCs did not differ between NAFLD patients and control patients. Similarly, in patients' PBMCs there were no differences in the expression of genes regulating β-oxidation (ACOX1, CPT1A, and ACC1) and inflammation (TNF, IL1B, IL6, IL8, IL10, and CCL2), or transcription factors controlling metabolism (FAS, LCN2, CEBPB, SREBP1, PPARA, and PPARG). + We have demonstrated that MCPIP1 protein levels are reduced in NAFLD patients, but further research is needed to investigate the specific role of MCPIP1 in NAFL initiation and the transition to NASH. + Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Association for the Study of Liver Diseases. + + + + Pydyn + Natalia + N + 0000-0002-9145-1979 + + Department of General Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland. + + + + Kadluczka + Justyna + J + 0000-0002-2341-2994 + + Department of General Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland. + + + Department of Neuropsychopharmacology, Maj Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland. + + + + Major + Piotr + P + 0000-0001-6552-7979 + + 2nd Department of General Surgery, Jagiellonian University Medical College, Krakow, Poland. + + + + Hutsch + Tomasz + T + 0000-0001-6491-3800 + + Department of Pathology and Veterinary Diagnostics, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland. + + + Veterinary Diagnostic Laboratory ALAB Bioscience, Warsaw, Poland. + + + + Belamri + Kinga + K + 0000-0001-8698-3068 + + Veterinary Diagnostic Laboratory ALAB Bioscience, Warsaw, Poland. + + + + Malczak + Piotr + P + 0000-0002-2142-7121 + + 2nd Department of General Surgery, Jagiellonian University Medical College, Krakow, Poland. + + + + Radkowiak + Dorota + D + 0000-0002-8158-6116 + + 2nd Department of General Surgery, Jagiellonian University Medical College, Krakow, Poland. + + + + Budzynski + Andrzej + A + 0000-0003-3021-6470 + + 2nd Department of General Surgery, Jagiellonian University Medical College, Krakow, Poland. + + + + Miekus + Katarzyna + K + 0000-0002-2716-203 + + Department of General Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland. + + + + Jura + Jolanta + J + 0000-0002-0816-3475 + + Department of General Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland. + + + + Kotlinowski + Jerzy + J + 0000-0002-3133-3364 + + Department of General Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland. + + + + eng + + Journal Article + + + 2023 + 02 + 20 + +
+ + United States + Hepatol Commun + 101695860 + 2471-254X + + IM +
+ + + + 2022 + 05 + 30 + + + 2022 + 09 + 20 + + + 2023 + 2 + 22 + 13 + 41 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809310 + 10.1097/HC9.0000000000000008 + 02009842-202303010-00016 + + + + Estes C, Anstee QM, Arias-Loste MT, Bantel H, Bellentani S, Caballeria J, et al. Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016–2030. J Hepatol. 2018;69:896–904. + + + Pydyn N, Miękus K, Jura J, Kotlinowski J. New therapeutic strategies in nonalcoholic fatty liver disease: a focus on promising drugs for nonalcoholic steatohepatitis. Pharmacol Rep. 2020;72:1–12. + + + Singh S, Allen AM, Wang Z, Prokop LJ, Murad MH, Loomba R. Fibrosis progression in nonalcoholic fatty liver versus nonalcoholic steatohepatitis: a systematic review and meta-analysis of paired-biopsy studies. Clin Gastroenterol Hepatol. 2015;13:643–654. + + + Musson R, Szukała W, Jura J. MCPIP1 RNase and Its Multifaceted Role. Int J Mol Sci. 2020;21:7183. + + + Mino T, Murakawa Y, Fukao A, Vandenbon A, Wessels HH, et al. Regnase-1 and roquin regulate a common element in inflammatory mRNAs by spatiotemporally distinct mechanisms. Cell. 2015;161:1058–1073. + + + Suzuki H, Arase M, Matsuyama H, Choi YL, Ueno T, Mano H, et al. MCPIP1 ribonuclease antagonizes dicer and terminates microRNA biogenesis through precursor microRNA degradation. Mol Cell. 2011;44:424–436. + + + Liang J, Saad Y, Lei T, Wang J, Qi D, Yang Q, et al. MCP-induced protein 1 deubiquitinates TRAF proteins and negatively regulates JNK and NF-kappaB signaling. J Exp Med. 2010;207:2959–2973. + + + Pydyn N, Żurawek D, Kozieł J, Kus E, Wojnar-Lason K, Jasztal A, et al. Role of Mcpip1 in obesity-induced hepatic steatosis as determined by myeloid and liver-specific conditional knockouts. FEBS J. 2021;288:6563–6580. + + + Kotlinowski J, Hutsch T, Czyzynska-Cichon I, Wadowska M, Pydyn N, Jasztal A, et al. Deletion of Mcpip1 in Mcpip1fl/flAlbCre mice recapitulates the phenotype of human primary biliary cholangitis. Biochim Biophys Acta Mol Basis Dis. 2021;1867:166086. + + + Sun P, Lu YX, Cheng D, Zhang K, Zheng J, Liu Y, et al. Monocyte chemoattractant protein-induced protein 1 targets hypoxia-inducible factor 1α to protect against hepatic ischemia/reperfusion injury. Hepatology. 2018;68:2359–2375. + + + Lipert B, Wegrzyn P, Sell H, Eckel J, Winiarski M, Budzynski A, et al. Monocyte chemoattractant protein-induced protein 1 impairs adipogenesis in 3T3-L1 cells. Biochim Biophys Acta. 2014;1843:780–788. + + + Losko M, Dolicka D, Pydyn N, Jankowska U, Kedracka-Krok S, Kulecka M, et al. Integrative genomics reveal a role for MCPIP1 in adipogenesis and adipocyte metabolism. Cell Mol Life Sci. 2020;77:4899–4919. + + + Losko M, Lichawska-Cieslar A, Kulecka M, Paziewska A, Rumienczyk I, Mikula M, et al. Ectopic overexpression of MCPIP1 impairs adipogenesis by modulating microRNAs. Biochim Biophys Acta Mol Cell Res. 2018;1865:186–195. + + + Lipert B, Wilamowski M, Gorecki A, Jura J. MCPIP1, alias Regnase-1 binds and cleaves mRNA of C/EBPβ. PLoS One. 2017;12:e0174381. + + + Pawlak M, Lefebvre P, Staels B. Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease. J Hepatol. 2015;62:720–733. + + + Montagner A, Polizzi A, Fouche E, Ducheix S, Lippi Y, et al. Liver PPARalpha is crucial for whole-body fatty acid homeostasis and is protective against NAFLD. Gut. 2016;65:1202–1214. + + + Régnier M, Polizzi A, Smati S, Lukowicz C, Fougerat A, et al. Hepatocyte-specific deletion of Pparα promotes NAFLD in the context of obesity. Sci Rep. 2020;10:6489. + + + Francque S, Verrijken A, Caron S, Prawitt J, Paumelle R, Derudas B, et al. PPARalpha gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis. J Hepatol. 2015;63:164–173. + + + Fernandez-Miranda C, Perez-Carreras M, Colina F, Lopez-Alonso G, Vargas C, Solis-Herruzo JA. A pilot trial of fenofibrate for the treatment of non-alcoholic fatty liver disease. Dig Liver Dis. 2008;40:200–205. + + + Basaranoglu M, Acbay O, Sonsuz A. A controlled trial of gemfibrozil in the treatment of patients with nonalcoholic steatohepatitis. J Hepatol. 1999;31:384. + + + Nakamuta M, Morizono S, Soejima Y, Yoshizumi T, Aishima S, Takasugi S, et al. Short-term intensive treatment for donors with hepatic steatosis in living-donor liver transplantation. Transplantation. 2005;80:608–612. + + + Matsushita K, Takeuchi O, Standley DM, Kumagai Y, Kawagoe T, Miyake T, et al. Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay. Nature. 2009;458:1185–1190. + + + Wang K, Niu J, Kim H, Kolattukudy PE. Osteoclast precursor differentiation by MCPIP via oxidative stress, endoplasmic reticulum stress, and autophagy. J Mol Cell Biol. 2011;3:360–368. + + + Roy A, Zhang M, Saad Y, Kolattukudy PE. Antidicer RNAse activity of monocyte chemotactic protein-induced protein-1 is critical for inducing angiogenesis. Am J Physiol. 2015;305:C1021–C1032. + + + Dobosz E, Wilamowski M, Lech M, Bugara B, Jura J, Potempa J, et al. MCPIP-1, alias Regnase-1, controls epithelial inflammation by posttranscriptional regulation of IL-8 production. J Innate Immun. 2016;8:564–578. + + + Zhou Z, Miao R, Huang S, Elder B, Quinn T, Papasian CJ, et al. MCPIP1 deficiency in mice results in severe anemia related to autoimmune mechanisms. PLoS One. 2013;8:e82542. + + + Dobosz E, Lorenz G, Ribeiro A, Würf V, Wadowska M, Kotlinowski J, et al. Murine myeloid cell MCPIP1 suppresses autoimmunity by regulating B-cell expansion and differentiation. Dis Model Mech. 2021;14:dmm047589. + + + Brancale J, Vilarinho S. A single cell gene expression atlas of 28 human livers. J Hepatol. 2021;75:219–220. + + + Crujeiras AB, Parra D, Milagro FI, Goyenechea E, Larrarte E, Margareto J, et al. Differential expression of oxidative stress and inflammation related genes in peripheral blood mononuclear cells in response to a low-calorie diet: a nutrigenomics study. OMICS. 2008;12:251–261. + + + Caimari A, Oliver P, Keijer J, Palou A. Peripheral blood mononuclear cells as a model to study the response of energy homeostasis-related genes to acute changes in feeding conditions. OMICS. 2010;14:129–141. + + + Goldstein S, Blecher M, Binder R, Perrino PV, Recant L. Hormone receptors, 5. Binding of glucagon and insulin to human circulating mononuclear cells in diabetes mellitus. Endocr Res Commun. 1975;2:367–376. + + + Tsiotra PC, Pappa V, Raptis SA, Tsigos C. Expression of the long and short leptin receptor isoforms in peripheral blood mononuclear cells: implications for leptin’s actions. Metabolism. 2000;49:1537–1541. + + + Mizgalska D, Wegrzyn P, Murzyn K, Kasza A, Koj A, Jura J, et al. Interleukin-1-inducible MCPIP protein has structural and functional properties of RNase and participates in degradation of IL-1beta mRNA. FEBS J. 2009;276:7386–7399. + + + Kado A, Tsutsumi T, Enooku K, Fujinaga H, Ikeuchi K, Okushin K, et al. Noninvasive diagnostic criteria for nonalcoholic steatohepatitis based on gene expression levels in peripheral blood mononuclear cells. J Gastroenterol. 2019;54:730–741. + + + Lin SZ, Fan JG. Peripheral immune cells in NAFLD patients: a spyhole to disease progression. EBioMedicine. 2022;75:103768. + + + Diedrich T, Kummer S, Galante A, Drolz A, Schlicker V, Lohse AW, et al. Characterization of the immune cell landscape of patients with NAFLD. PLoS One. 2020;15:e0230307. + + + +
+ + + 36809308 + + 2023 + 02 + 22 + +
+ + 1935-5548 + + + 2023 + Feb + 21 + + + Diabetes care + Diabetes Care + + Performance of the Dexcom G6 Continuous Glucose Monitoring (CGM) System During Cardiac Surgery Using Hypothermic Extracorporeal Circulation. + dc222260 + 10.2337/dc22-2260 + + Continuous glucose monitoring (CGM) may be challenged by extreme conditions during cardiac surgery using hypothermic extracorporeal circulation (ECC). + We evaluated the Dexcom G6 sensor in 16 subjects undergoing cardiac surgery with hypothermic ECC, of whom 11 received deep hypothermic circulatory arrest (DHCA). Arterial blood glucose, quantified by the Accu-Chek Inform II meter, served as reference. + Intrasurgery mean absolute relative difference (MARD) of 256 paired CGM/reference values was 23.8%. MARD was 29.1% during ECC (154 pairs) and 41.6% immediately after DHCA (10 pairs), with a negative bias (signed relative difference: -13.7%, -26.6%, and -41.6%). During surgery, 86.3% pairs were in Clarke error grid zones A or B and 41.0% of sensor readings fulfilled the International Organization for Standardization (ISO) 15197:2013 norm. Postsurgery, MARD was 15.0%. + Cardiac surgery using hypothermic ECC challenges the accuracy of the Dexcom G6 CGM although recovery appears to occur thereafter. + © 2023 by the American Diabetes Association. + + + + Herzig + David + D + + Department Diabetes, Endocrinology, Nutritional Medicine and Metabolism, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. + + + + Vettoretti + Martina + M + + Department of Information Engineering, University of Padova, Padova, Italy. + + + + Guensch + Dominik P + DP + + Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. + + + + Melmer + Andreas + A + + Department Diabetes, Endocrinology, Nutritional Medicine and Metabolism, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. + + + + Schürch + Daniel + D + + Department Diabetes, Endocrinology, Nutritional Medicine and Metabolism, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. + + + + Roos + Jonathan + J + + Department Diabetes, Endocrinology, Nutritional Medicine and Metabolism, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. + + + + Goerg + Arna M C + AMC + + Department Diabetes, Endocrinology, Nutritional Medicine and Metabolism, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. + + + + Krutkyte + Gabija + G + + Department Diabetes, Endocrinology, Nutritional Medicine and Metabolism, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. + + + + Cecchini + Luca + L + + Department Diabetes, Endocrinology, Nutritional Medicine and Metabolism, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. + + + Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. + + + + Facchinetti + Andrea + A + + Department of Information Engineering, University of Padova, Padova, Italy. + + + + Vogt + Andreas P + AP + + Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. + + + + Bally + Lia + L + 0000-0003-1993-7672 + + Department Diabetes, Endocrinology, Nutritional Medicine and Metabolism, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Diabetes Care + 7805975 + 0149-5992 + + IM +
+ + + + 2022 + 11 + 20 + + + 2023 + 01 + 23 + + + 2023 + 2 + 22 + 13 + 41 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809308 + 148431 + 10.2337/dc22-2260 + + +
+ + + 36809311 + + 2023 + 02 + 22 + +
+ + 1479-683X + + + 2023 + Feb + 21 + + + European journal of endocrinology + Eur J Endocrinol + + The ultra-acute steroid response to traumatic injury: a cohort study. + lvad024 + 10.1093/ejendo/lvad024 + + Trauma-induced steroid changes have been studied post-hospital admission, resulting in a lack of understanding of the speed and extent of the immediate endocrine response to injury. The Golden Hour Study was designed to capture the ultra-acute response to traumatic injury. + An observational cohort study including adult male trauma patients <60 years, with blood samples drawn <1 hour of major trauma by pre-hospital emergency responders. + We recruited 31 adult male trauma patients (mean age 28 (range 19-59) years) with a mean injury severity score of 16 (IQR 10-21). The median time to first sample was 35 (range 14-56) minutes, with follow-up samples collected 4-12 and 48-72 hours post-injury. Serum steroids in patients and age- and sex-matched healthy controls (n=34) were analysed by tandem mass spectrometry. + Within one hour of injury, we observed an increase in glucocorticoid and adrenal androgen biosynthesis. Cortisol and 11-hydroxyandrostendione increased rapidly while cortisone and 11-ketoandrostenedione decreased, reflective of increased cortisol and 11-oxygenated androgen precursor biosynthesis by 11β-hydroxylase and increased cortisol activation by 11β-hydroxysteroid dehydrogenase type 1. Active classic gonadal androgens testosterone and 5α-dihydrotestosterone decreased while the active 11-oxygenated androgen 11-ketotestosterone maintained pre-injury levels. + Changes in steroid biosynthesis and metabolism occur within minutes of traumatic injury. Studies that address whether ultra-early changes in steroid metabolism are associated with patient outcomes are now required. + © The Author(s) 2023. Published by Oxford University Press on behalf of (ESE) European Society of Endocrinology. + + + + Bentley + Conor + C + + Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom. + + + National Institute for Health Research Surgical Reconstruction and Microbiology Research Centre, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom. + + + School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United Kingdom. + + + + Hazeldine + Jon + J + 0000-0002-4280-4889 + + Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom. + + + National Institute for Health Research Surgical Reconstruction and Microbiology Research Centre, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom. + + + + Bravo + Laura + L + + Institute of Cancer and Genomic Sciences, Centre for Computational Biology, University of Birmingham, Birmingham, B15 2TT, United Kingdom. + + + + Taylor + Angela E + AE + + Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, B15 2TT, United Kingdom. + + + + Gilligan + Lorna C + LC + + Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, B15 2TT, United Kingdom. + + + + Shaheen + Fozia + F + + Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, B15 2TT, United Kingdom. + + + + Acharjee + Animesh + A + 0000-0003-2735-7010 + + National Institute for Health Research Surgical Reconstruction and Microbiology Research Centre, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom. + + + Institute of Cancer and Genomic Sciences, Centre for Computational Biology, University of Birmingham, Birmingham, B15 2TT, United Kingdom. + + + Institute of Translational Medicine, University Hospitals Birmingham NHS Foundation Trust, B15 2TT, Birmingham, United Kingdom. + + + + Gkoutos + George + G + + National Institute for Health Research Surgical Reconstruction and Microbiology Research Centre, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom. + + + Institute of Cancer and Genomic Sciences, Centre for Computational Biology, University of Birmingham, Birmingham, B15 2TT, United Kingdom. + + + Institute of Translational Medicine, University Hospitals Birmingham NHS Foundation Trust, B15 2TT, Birmingham, United Kingdom. + + + Medical Research Council Health Data Research UK (HDR), United Kingdom. + + + + Foster + Mark A + MA + + Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom. + + + National Institute for Health Research Surgical Reconstruction and Microbiology Research Centre, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom. + + + Royal Centre for Defence Medicine, Birmingham Research Park, Birmingham, B15 2SQ, United Kingdom. + + + + Arlt + Wiebke + W + 0000-0001-5106-9719 + + Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, B15 2TT, United Kingdom. + + + National Institute for Health Research Birmingham Biomedical Research Centre, University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Birmingham, B15 2GW, Birmingham. + + + + Lord + Janet M + JM + + Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom. + + + National Institute for Health Research Surgical Reconstruction and Microbiology Research Centre, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom. + + + National Institute for Health Research Birmingham Biomedical Research Centre, University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Birmingham, B15 2GW, Birmingham. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Eur J Endocrinol + 9423848 + 0804-4643 + + IM + + 11-oxygenated androgens + glucocorticoids + major trauma + mass spectrometry + steroids + +
+ + + + 2022 + 05 + 18 + + + 2022 + 12 + 21 + + + 2023 + 02 + 08 + + + 2023 + 2 + 22 + 13 + 41 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809311 + 7049580 + 10.1093/ejendo/lvad024 + + +
+ + + 36809299 + + 2023 + 02 + 22 + +
+ + 2379-3708 + + + 2023 + Feb + 21 + + + JCI insight + JCI Insight + + Mechanism and intervention of murine transfusion-related acute lung injury caused by anti-CD36 antibodies. + 10.1172/jci.insight.165142 + e165142 + + Anti-CD36 antibodies have been suggested to induce transfusion-related acute lung injury (TRALI) upon blood transfusion, particularly in Asian populations. However, little is known about the pathological mechanism of anti-CD36-mediated TRALI, and potential therapies haven't yet been identified. Here, we developed a murine model of anti-CD36-mediated TRALI to address these questions. We found that administration of mouse monoclonal antibody against CD36 (mAb GZ1) or human anti-CD36 IgG, but not GZ1 F(ab')2 fragments, induced severe TRALI in Cd36+/+ male mice. Pre-depletion of recipient monocytes or complement, but not neutrophils or platelets, prevented the development of murine TRALI. Moreover, plasma C5a levels after TRALI induction by anti-CD36 were increased more than 3-fold, implying a critical role of complement C5 activation in the mechanism of Fc-dependent anti-CD36-mediated TRALI. Administration of GZ1 F(ab')2, antioxidant (NAC) or C5-blocker (mAb BB5.1) before TRALI induction completely protected mice from anti-CD36-mediated TRALI. Although no significant amelioration in TRALI was observed when mice were injected with GZ1 F(ab')2 after TRALI induction, significant improvement was achieved when mice were treated post-induction with NAC or anti-C5. Importantly, anti-C5 treatment completely rescued mice from TRALI, suggesting the potential role of existing anti-C5 drugs in the treatment of patients with TRALI caused by anti-CD36. + + + + Chen + Da-Wei + DW + + Guangzhou Blood Centre, Guangzhou, China. + + + + Kang + Tian + T + + The First School of Clinical Medicine, Southern Medical University, Guangzhou, China. + + + + Xu + Xiu-Zhang + XZ + + Institute of Blood Transfusion, Guangzhou Blood Centre, Guangzhou, China. + + + + Xia + Wen-Jie + WJ + + Institute of Blood Transfusion, Guangzhou Blood Centre, Guangzhou, China. + + + + Ye + Xin + X + + Institute of Blood Transfusion, Guangzhou Blood Centre, Guangzhou, China. + + + + Wu + Yong-Bin + YB + + Blood Transfusion, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. + + + + Xu + Yao-Ri + YR + + Institute of Blood Transfusion, Guangzhou Blood Centre, Guangzhou, China. + + + + Liu + Jing + J + + Institute of Blood Transfusion, Guangzhou Blood Centre, Guangzhou, China. + + + + Ren + Hui + H + + Institute of Blood Transfusion, Guangzhou Blood Centre, Guangzhou, China. + + + + Deng + Jing + J + + Institute of Blood Transfusion, Guangzhou Blood Centre, Guangzhou, China. + + + + Chen + Yang-Kai + YK + + Institute of Blood Transfusion, Guangzhou Blood Centre, Guangzhou, China. + + + + Ding + Hao-Qiang + HQ + + Institute of Blood Transfusion, Guangzhou Blood Centre, Guangzhou, China. + + + + Aslam + Muhammad + M + + Department of Cardiology and Angiology, Justus Liebig University, Giessen, Germany. + + + + Zelek + Wioleta M + WM + + Dementia Research Institute, Cardiff University, Cardiff, United Kingdom. + + + + Morgan + B Paul + BP + + Dementia Research Institute, Cardiff University, Cardiff, United Kingdom. + + + + Kapur + Rick + R + + Department of Experimental Immunohematology, Sanquin Research, Amsterdam, Netherlands. + + + + Santoso + Sentot + S + + Institute of Clinical Immunology and Transfusion Medicine, Justus Liebig University, Giessen, Germany. + + + + Fu + Yong-Shui + YS + + Institute of Blood Transfusion, Guangzhou Blood Centre, Guangzhou, China. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + JCI Insight + 101676073 + 2379-3708 + + IM + + Complement + Drug therapy + Immunology + Monocytes + Pulmonology + +
+ + + + 2023 + 2 + 22 + 13 + 40 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809299 + 165142 + 10.1172/jci.insight.165142 + + +
+ + + 36809319 + + 2023 + 02 + 22 + +
+ + 1538-3598 + + 329 + 7 + + 2023 + Feb + 21 + + + JAMA + JAMA + + Notice of Retraction and Replacement. Ellison-Barnes et al. Trends in Obesity Prevalence Among Adults Aged 18 Through 25 Years, 1976-2018. JAMA. 2021;326(20):2073-2074. + + 595-596 + + 10.1001/jama.2022.23438 + + + Ellison-Barnes + Alejandra + A + + Division of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland. + + + + Johnson + Sara + S + + Division of General Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland. + + + + Gudzune + Kimberly + K + + Division of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland. + + + + eng + + Journal Article + +
+ + United States + JAMA + 7501160 + 0098-7484 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 41 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809319 + 2801674 + 10.1001/jama.2022.23438 + + +
+ + + 36809318 + + 2023 + 02 + 22 + +
+ + 1538-3598 + + 329 + 7 + + 2023 + Feb + 21 + + + JAMA + JAMA + + Glioblastoma and Other Primary Brain Malignancies in Adults: A Review. + + 574-587 + + 10.1001/jama.2023.0023 + + Malignant primary brain tumors cause more than 15 000 deaths per year in the United States. The annual incidence of primary malignant brain tumors is approximately 7 per 100 000 individuals and increases with age. Five-year survival is approximately 36%. + Approximately 49% of malignant brain tumors are glioblastomas, and 30% are diffusely infiltrating lower-grade gliomas. Other malignant brain tumors include primary central nervous system (CNS) lymphoma (7%) and malignant forms of ependymomas (3%) and meningiomas (2%). Symptoms of malignant brain tumors include headache (50%), seizures (20%-50%), neurocognitive impairment (30%-40%), and focal neurologic deficits (10%-40%). Magnetic resonance imaging before and after a gadolinium-based contrast agent is the preferred imaging modality for evaluating brain tumors. Diagnosis requires tumor biopsy with consideration of histopathological and molecular characteristics. Treatment varies by tumor type and often includes a combination of surgery, chemotherapy, and radiation. For patients with glioblastoma, the combination of temozolomide with radiotherapy improved survival when compared with radiotherapy alone (2-year survival, 27.2% vs 10.9%; 5-year survival, 9.8% vs 1.9%; hazard ratio [HR], 0.6 [95% CI, 0.5-0.7]; P < .001). In patients with anaplastic oligodendroglial tumors with 1p/19q codeletion, probable 20-year overall survival following radiotherapy without vs with the combination of procarbazine, lomustine, and vincristine was 13.6% vs 37.1% (80 patients; HR, 0.60 [95% CI, 0.35-1.03]; P = .06) in the EORTC 26951 trial and 14.9% vs 37% in the RTOG 9402 trial (125 patients; HR, 0.61 [95% CI, 0.40-0.94]; P = .02). Treatment of primary CNS lymphoma includes high-dose methotrexate-containing regimens, followed by consolidation therapy with myeloablative chemotherapy and autologous stem cell rescue, nonmyeloablative chemotherapy regimens, or whole brain radiation. + The incidence of primary malignant brain tumors is approximately 7 per 100 000 individuals, and approximately 49% of primary malignant brain tumors are glioblastomas. Most patients die from progressive disease. First-line therapy for glioblastoma is surgery followed by radiation and the alkylating chemotherapeutic agent temozolomide. + + + + Schaff + Lauren R + LR + + Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York. + + + Department of Neurology, Weill Cornell Medicine, New York, New York. + + + + Mellinghoff + Ingo K + IK + + Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York. + + + Department of Neurology, Weill Cornell Medicine, New York, New York. + + + Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York. + + + Department of Pharmacology, Weill Cornell Medicine, New York, New York. + + + + eng + + Journal Article + +
+ + United States + JAMA + 7501160 + 0098-7484 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 41 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809318 + 2801673 + 10.1001/jama.2023.0023 + + +
+ + + 36809328 + + 2023 + 02 + 22 + +
+ + 1538-3598 + + 329 + 7 + + 2023 + Feb + 21 + + + JAMA + JAMA + + Review of Pulmonary Embolism. + + 592 + + 10.1001/jama.2022.22235 + + + Porres-Aguilar + Mateo + M + + Department of Internal Medicine, Texas Tech University Health Sciences Center, El Paso. + + + + Anaya-Ayala + Javier E + JE + + Division of Vascular Surgery, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México City, México. + + + + Mukherjee + Debabrata + D + + Division of Cardiovascular Diseases, Texas Tech University Health Sciences Center, El Paso. + + + + eng + + Journal Article + +
+ + United States + JAMA + 7501160 + 0098-7484 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 42 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809328 + 2801687 + 10.1001/jama.2022.22235 + + +
+ + + 36809329 + + 2023 + 02 + 22 + +
+ + 1538-3598 + + 329 + 7 + + 2023 + Feb + 21 + + + JAMA + JAMA + + Review of Pulmonary Embolism. + + 592-593 + + 10.1001/jama.2022.22232 + + + Xiong + Wei + W + + Department of Pulmonary and Critical Care Medicine, Xinhua Hospital, Shanghai, China. + + + + eng + + Journal Article + +
+ + United States + JAMA + 7501160 + 0098-7484 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 42 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809329 + 2801688 + 10.1001/jama.2022.22232 + + +
+ + + 36809320 + + 2023 + 02 + 22 + +
+ + 1538-3598 + + 329 + 7 + + 2023 + Feb + 21 + + + JAMA + JAMA + + The Hole. + + 597 + + 10.1001/jama.2023.0212 + + + O'Connor + Deirdre + D + + Bucknell University, Lewisburg, Pennsylvania. + + + + eng + + Journal Article + +
+ + United States + JAMA + 7501160 + 0098-7484 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 42 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809320 + 2801676 + 10.1001/jama.2023.0212 + + +
+ + + 36809323 + + 2023 + 02 + 22 + +
+ + 1538-3598 + + 329 + 7 + + 2023 + Feb + 21 + + + JAMA + JAMA + + Association of African Ancestry-Specific APOE Missense Variant R145C With Risk of Alzheimer Disease. + + 551-560 + + 10.1001/jama.2023.0268 + + Numerous studies have established the association of the common APOE ε2 and APOE ε4 alleles with Alzheimer disease (AD) risk across ancestries. Studies of the interaction of these alleles with other amino acid changes on APOE in non-European ancestries are lacking and may improve ancestry-specific risk prediction. + To determine whether APOE amino acid changes specific to individuals of African ancestry modulate AD risk. + Case-control study including 31 929 participants and using a sequenced discovery sample (Alzheimer Disease Sequencing Project; stage 1) followed by 2 microarray imputed data sets derived from the Alzheimer Disease Genetic Consortium (stage 2, internal replication) and the Million Veteran Program (stage 3, external validation). This study combined case-control, family-based, population-based, and longitudinal AD cohorts, which recruited participants (1991-2022) in primarily US-based studies with 1 US/Nigerian study. Across all stages, individuals included in this study were of African ancestry. + Two APOE missense variants (R145C and R150H) were assessed, stratified by APOE genotype. + The primary outcome was AD case-control status, and secondary outcomes included age at AD onset. + Stage 1 included 2888 cases (median age, 77 [IQR, 71-83] years; 31.3% male) and 4957 controls (median age, 77 [IQR, 71-83] years; 28.0% male). In stage 2, across multiple cohorts, 1201 cases (median age, 75 [IQR, 69-81] years; 30.8% male) and 2744 controls (median age, 80 [IQR, 75-84] years; 31.4% male) were included. In stage 3, 733 cases (median age, 79.4 [IQR, 73.8-86.5] years; 97.0% male) and 19 406 controls (median age, 71.9 [IQR, 68.4-75.8] years; 94.5% male) were included. In ε3/ε4-stratified analyses of stage 1, R145C was present in 52 individuals with AD (4.8%) and 19 controls (1.5%); R145C was associated with an increased risk of AD (odds ratio [OR], 3.01; 95% CI, 1.87-4.85; P = 6.0 × 10-6) and was associated with a reported younger age at AD onset (β, -5.87 years; 95% CI, -8.35 to -3.4 years; P = 3.4 × 10-6). Association with increased AD risk was replicated in stage 2 (R145C was present in 23 individuals with AD [4.7%] and 21 controls [2.7%]; OR, 2.20; 95% CI, 1.04-4.65; P = .04) and was concordant in stage 3 (R145C was present in 11 individuals with AD [3.8%] and 149 controls [2.7%]; OR, 1.90; 95% CI, 0.99-3.64; P = .051). Association with earlier AD onset was replicated in stage 2 (β, -5.23 years; 95% CI, -9.58 to -0.87 years; P = .02) and stage 3 (β, -10.15 years; 95% CI, -15.66 to -4.64 years; P = 4.0 × 10-4). No significant associations were observed in other APOE strata for R145C or in any APOE strata for R150H. + In this exploratory analysis, the APOE ε3[R145C] missense variant was associated with an increased risk of AD among individuals of African ancestry with the ε3/ε4 genotype. With additional external validation, these findings may inform AD genetic risk assessment in individuals of African ancestry. + + + + Le Guen + Yann + Y + + Department of Neurology and Neurological Sciences, Stanford University, Stanford, California. + + + Institut du Cerveau-Paris Brain Institute-ICM, Paris, France. + + + + Raulin + Ana-Caroline + AC + + Department of Neuroscience, Mayo Clinic, Jacksonville, Florida. + + + + Logue + Mark W + MW + + National Center for PTSD, Behavioral Sciences Division, VA Boston Healthcare System, Boston, Massachusetts. + + + Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts. + + + Biomedical Genetics, Boston University School of Medicine, Boston, Massachusetts. + + + Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts. + + + + Sherva + Richard + R + + Biomedical Genetics, Boston University School of Medicine, Boston, Massachusetts. + + + + Belloy + Michael E + ME + + Department of Neurology and Neurological Sciences, Stanford University, Stanford, California. + + + + Eger + Sarah J + SJ + + Department of Neurology and Neurological Sciences, Stanford University, Stanford, California. + + + + Chen + Annabel + A + + Department of Neurology and Neurological Sciences, Stanford University, Stanford, California. + + + + Kennedy + Gabriel + G + + Department of Neurology and Neurological Sciences, Stanford University, Stanford, California. + + + + Kuchenbecker + Lindsey + L + + Department of Neuroscience, Mayo Clinic, Jacksonville, Florida. + + + + O'Leary + Justin P + JP + + Department of Neuroscience, Mayo Clinic, Jacksonville, Florida. + + + + Zhang + Rui + R + + National Center for PTSD, Behavioral Sciences Division, VA Boston Healthcare System, Boston, Massachusetts. + + + + Merritt + Victoria C + VC + + Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, California. + + + Department of Psychiatry, University of California, San Diego, La Jolla. + + + VA San Diego Healthcare System, San Diego, California. + + + + Panizzon + Matthew S + MS + + Department of Psychiatry, University of California, San Diego, La Jolla. + + + Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla. + + + Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. + + + + Hauger + Richard L + RL + + Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, California. + + + Department of Psychiatry, University of California, San Diego, La Jolla. + + + Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla. + + + + Gaziano + J Michael + JM + + Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. + + + Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston. + + + + Bu + Guojun + G + + Department of Neuroscience, Mayo Clinic, Jacksonville, Florida. + + + + Thornton + Timothy A + TA + + Department of Biostatistics, University of Washington, Seattle. + + + + Farrer + Lindsay A + LA + + Biomedical Genetics, Boston University School of Medicine, Boston, Massachusetts. + + + + Napolioni + Valerio + V + + School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy. + + + + He + Zihuai + Z + + Department of Neurology and Neurological Sciences, Stanford University, Stanford, California. + + + Quantitative Sciences Unit, Department of Medicine, Stanford University, Stanford, California. + + + + Greicius + Michael D + MD + + Department of Neurology and Neurological Sciences, Stanford University, Stanford, California. + + + + eng + + Journal Article + +
+ + United States + JAMA + 7501160 + 0098-7484 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 42 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809323 + 2801680 + 10.1001/jama.2023.0268 + + +
+ + + 36809327 + + 2023 + 02 + 22 + +
+ + 1538-3598 + + 329 + 7 + + 2023 + Feb + 21 + + + JAMA + JAMA + + Review of Pulmonary Embolism. + + 593 + + 10.1001/jama.2022.22238 + + + Vinson + David R + DR + + Department of Emergency Medicine, Kaiser Permanente Roseville Medical Center, Roseville, California. + + + + Sperling + Jeffrey D + JD + + Department of Maternal-Fetal Medicine, Kaiser Permanente Modesto Medical Center, Modesto, California. + + + + Roubinian + Nareg H + NH + + Department of Pulmonary and Critical Care Medicine, Kaiser Permanente Oakland Medical Center, Oakland, California. + + + + eng + + Journal Article + +
+ + United States + JAMA + 7501160 + 0098-7484 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 42 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809327 + 2801686 + 10.1001/jama.2022.22238 + + +
+ + + 36809322 + + 2023 + 02 + 22 + +
+ + 1538-3598 + + 329 + 7 + + 2023 + Feb + 21 + + + JAMA + JAMA + + History of Low Hourly Wage and All-Cause Mortality Among Middle-aged Workers. + + 561-573 + + 10.1001/jama.2023.0367 + + Earning a low wage is an increasingly recognized public health concern, yet little research exists on the long-term health consequences of sustained low-wage earning. + To examine the association of sustained low-wage earning and mortality in a sample of workers with hourly wage reported biennially during peak midlife earning years. + This longitudinal study included 4002 US participants, aged 50 years or older, from 2 subcohorts of the Health and Retirement Study (1992-2018) who worked for pay and reported earning hourly wages at 3 or more time points during a 12-year period during their midlife (1992-2004 or 1998-2010). Outcome follow-up occurred from the end of the respective exposure periods until 2018. + Low-wage-less than the hourly wage for full-time, full-year work at the federal poverty line-earning history was categorized as never earning a low wage, intermittently earning a low wage, and sustained earning a low wage. + Cox proportional hazards and additive hazards regression models sequentially adjusted for sociodemographics, and economic and health covariates were used to estimate associations between low-wage history and all-cause mortality. We examined interaction with sex or employment stability on multiplicative and additive scales. + Of the 4002 workers (aged 50-57 years at the beginning of exposure period and 61-69 years at the end), 1854 (46.3%) were female; 718 (17.9%) experienced employment instability; 366 (9.1%) had a history of sustained low-wage earning; 1288 (32.2%) had intermittent low-wage earning periods; and 2348 (58.7%) had never earned a low wage. In unadjusted analyses, those who had never earned low wages experienced 199 deaths per 10 000 person-years, those with intermittent low wages, 208 deaths per 10 000 person-years, and those with sustained low wages, 275 deaths per 10 000 person-years. In models adjusted for key sociodemographic variables, sustained low-wage earning was associated with mortality (hazard ratio [HR], 1.35; 95% CI, 1.07-1.71) and excess deaths (66; 95% CI, 6.6-125); these findings were attenuated with additional adjustments for economic and health covariates. Significant excess death and elevated mortality risk were observed for workers with sustained low-wage exposure and employment fluctuations (eg, for sustained low-wage × employment fluctuated, HR, 2.18; 95% CI, 1.35-3.53; for sustained low-wage × stable employment, HR, 1.17; 95% CI, 0.89,-1.54; P for interaction = .003). + Sustained low-wage earning may be associated with elevated mortality risk and excess deaths, especially when experienced alongside unstable employment. If causal, our findings suggest that social and economic policies that improve the financial standing of low-wage workers (eg, minimum wage laws) could improve mortality outcomes. + + + + Kezios + Katrina L + KL + + Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York. + + + + Lu + Peiyi + P + + Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York. + + + + Calonico + Sebastian + S + + Department of Health Policy and Management, Mailman School of Public Health, Columbia University, New York, New York. + + + + Al Hazzouri + Adina Zeki + AZ + + Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York. + + + + eng + + Journal Article + +
+ + United States + JAMA + 7501160 + 0098-7484 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 42 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809322 + 2801679 + 10.1001/jama.2023.0367 + + +
+ + + 36809330 + + 2023 + 02 + 22 + +
+ + 1538-3598 + + 329 + 7 + + 2023 + Feb + 21 + + + JAMA + JAMA + + Dissemination of the Results of Pediatric Clinical Trials Funded by the US National Institutes of Health. + + 590-592 + + 10.1001/jama.2022.24025 + + + Rees + Chris A + CA + + Division of Pediatric Emergency Medicine, Emory University School of Medicine, Atlanta, Georgia. + + + + Narang + Claire + C + + Computational Health Informatics Program, Boston Children's Hospital, Boston, Massachusetts. + + + + Westbrook + Adrianna + A + + Pediatric Biostatistics Core, Emory University School of Medicine, Atlanta, Georgia. + + + + Bourgeois + Florence T + FT + + Department of Pediatrics, Harvard Medical School, Boston, Massachusetts. + + + + eng + + Journal Article + +
+ + United States + JAMA + 7501160 + 0098-7484 + + IM + + This study examines practices related to trial registration and results submission in ClinicalTrials.gov and publication of pediatric clinical trials funded by the National Institutes of Health. + +
+ + + + 2023 + 2 + 22 + 13 + 42 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809330 + 2801689 + 10.1001/jama.2022.24025 + + +
+ + + 36809325 + + 2023 + 02 + 22 + +
+ + 1538-3598 + + 329 + 7 + + 2023 + Feb + 21 + + + JAMA + JAMA + + Review of Pulmonary Embolism-Reply. + + 593-594 + + 10.1001/jama.2022.22241 + + + Freund + Yonathan + Y + + Sorbonne Université, Hôpital Pitié-Salpêtrière, Paris, France. + + + + Cohen-Aubart + Fleur + F + + Sorbonne Université, Hôpital Pitié-Salpêtrière, Paris, France. + + + + Bloom + Ben + B + + Emergency Department, Barts Health NHS Trust, London, United Kingdom. + + + + eng + + Journal Article + +
+ + United States + JAMA + 7501160 + 0098-7484 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 42 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809325 + 2801684 + 10.1001/jama.2022.22241 + + +
+ + + 36809326 + + 2023 + 02 + 22 + +
+ + 1538-3598 + + 329 + 7 + + 2023 + Feb + 21 + + + JAMA + JAMA + + Roflumilast Cream vs Vehicle Cream and Chronic Plaque Psoriasis. + + 594-595 + + 10.1001/jama.2022.22646 + + + Smith + Brandon + B + + Drexel University College of Medicine, Philadelphia, Pennsylvania. + + + + Collier + Michael R + MR + + USF Health Morsani College of Medicine, Tampa, Florida. + + + + Wu + Jashin J + JJ + + University of Miami Miller School of Medicine, Miami, Florida. + + + + eng + + Journal Article + +
+ + United States + JAMA + 7501160 + 0098-7484 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 42 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809326 + 2801685 + 10.1001/jama.2022.22646 + + +
+ + + 36809324 + + 2023 + 02 + 22 + +
+ + 1538-3598 + + 329 + 7 + + 2023 + Feb + 21 + + + JAMA + JAMA + + Roflumilast Cream vs Vehicle Cream and Chronic Plaque Psoriasis-Reply. + + 595 + + 10.1001/jama.2022.22649 + + + Lebwohl + Mark G + MG + + Icahn School of Medicine at Mount Sinai, New York, New York. + + + + Hebert + Adelaide A + AA + + SkiN Centre for Dermatology, Peterborough, Ontario, Canada. + + + + Gooderham + Melinda J + MJ + + McGovern Medical School at UTHealth Houston, Houston, Texas. + + + + eng + + Journal Article + +
+ + United States + JAMA + 7501160 + 0098-7484 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 42 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809324 + 2801683 + 10.1001/jama.2022.22649 + + +
+ + + 36809321 + + 2023 + 02 + 22 + +
+ + 1538-3598 + + 329 + 7 + + 2023 + Feb + 21 + + + JAMA + JAMA + + Aspirin Discontinuation at 24 to 28 Weeks' Gestation in Pregnancies at High Risk of Preterm Preeclampsia: A Randomized Clinical Trial. + + 542-550 + + 10.1001/jama.2023.0691 + + Aspirin reduces the incidence of preterm preeclampsia by 62% in pregnant individuals at high risk of preeclampsia. However, aspirin might be associated with an increased risk of peripartum bleeding, which could be mitigated by discontinuing aspirin before term (37 weeks of gestation) and by an accurate selection of individuals at higher risk of preeclampsia in the first trimester of pregnancy. + To determine whether aspirin discontinuation in pregnant individuals with normal soluble fms-like tyrosine kinase-1 to placental growth factor (sFlt-1:PlGF) ratio between 24 and 28 weeks of gestation was noninferior to aspirin continuation to prevent preterm preeclampsia. + Multicenter, open-label, randomized, phase 3, noninferiority trial conducted in 9 maternity hospitals across Spain. Pregnant individuals (n = 968) at high risk of preeclampsia during the first-trimester screening and an sFlt-1:PlGF ratio of 38 or less at 24 to 28 weeks of gestation were recruited between August 20, 2019, and September 15, 2021; of those, 936 were analyzed (intervention: n = 473; control: n = 463). Follow-up was until delivery for all participants. + Enrolled patients were randomly assigned in a 1:1 ratio to aspirin discontinuation (intervention group) or aspirin continuation until 36 weeks of gestation (control group). + Noninferiority was met if the higher 95% CI for the difference in preterm preeclampsia incidences between groups was less than 1.9%. + Among the 936 participants, the mean (SD) age was 32.4 (5.8) years; 3.4% were Black and 93% were White. The incidence of preterm preeclampsia was 1.48% (7/473) in the intervention group and 1.73% (8/463) in the control group (absolute difference, -0.25% [95% CI, -1.86% to 1.36%]), indicating noninferiority. + Aspirin discontinuation at 24 to 28 weeks of gestation was noninferior to aspirin continuation for preventing preterm preeclampsia in pregnant individuals at high risk of preeclampsia and a normal sFlt-1:PlGF ratio. + ClinicalTrials.gov Identifier: NCT03741179 and ClinicalTrialsRegister.eu Identifier: 2018-000811-26. + + + + Mendoza + Manel + M + + Maternal Fetal Medicine Unit, Department of Obstetrics, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona, Barcelona, Spain. + + + + Bonacina + Erika + E + + Maternal Fetal Medicine Unit, Department of Obstetrics, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona, Barcelona, Spain. + + + + Garcia-Manau + Pablo + P + + Maternal Fetal Medicine Unit, Department of Obstetrics, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona, Barcelona, Spain. + + + + López + Monica + M + + Department of Obstetrics, Hospital Universitari de Tarragona Joan XXIII, Tarragona, Spain. + + + + Caamiña + Sara + S + + Department of Obstetrics, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain. + + + + Vives + Àngels + À + + Department of Obstetrics, Consorci Sanitari de Terrassa, Terrassa, Spain. + + + + Lopez-Quesada + Eva + E + + Department of Obstetrics, Hospital Universitari Mútua Terrassa, Terrassa, Spain. + + + + Ricart + Marta + M + + Department of Obstetrics, Hospital Universitari Germans Trias i Pujol, Badalona, Spain. + + + + Maroto + Anna + A + + Department of Obstetrics, Hospital Universitari de Girona Doctor Josep Trueta, Girona, Spain. + + + + de Mingo + Laura + L + + Department of Obstetrics, Hospital Universitario Severo Ochoa, Leganés, Spain. + + + + Pintado + Elena + E + + Department of Obstetrics, Hospital Universitario de Getafe, Getafe, Spain. + + + + Ferrer-Costa + Roser + R + + Department of Biochemistry, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain. + + + + Martin + Lourdes + L + + Department of Obstetrics, Hospital Universitari de Tarragona Joan XXIII, Tarragona, Spain. + + + + Rodríguez-Zurita + Alicia + A + + Department of Obstetrics, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain. + + + + Garcia + Esperanza + E + + Department of Obstetrics, Consorci Sanitari de Terrassa, Terrassa, Spain. + + + + Pallarols + Mar + M + + Department of Obstetrics, Hospital Universitari Mútua Terrassa, Terrassa, Spain. + + + + Vidal-Sagnier + Laia + L + + Department of Obstetrics, Hospital Universitari Germans Trias i Pujol, Badalona, Spain. + + + + Teixidor + Mireia + M + + Department of Obstetrics, Hospital Universitari de Girona Doctor Josep Trueta, Girona, Spain. + + + + Orizales-Lago + Carmen + C + + Department of Obstetrics, Hospital Universitario Severo Ochoa, Leganés, Spain. + + + + Pérez-Gomez + Adela + A + + Department of Obstetrics, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain. + + + + Ocaña + Vanesa + V + + Department of Obstetrics, Hospital Universitario de Getafe, Getafe, Spain. + + + + Puerto + Linda + L + + Department of Obstetrics, Hospital Universitari de Tarragona Joan XXIII, Tarragona, Spain. + + + + Millán + Pilar + P + + Department of Obstetrics, Consorci Sanitari de Terrassa, Terrassa, Spain. + + + + Alsius + Mercè + M + + Department of Biochemistry, Hospital Universitari de Girona Doctor Josep Trueta, Girona, Spain. + + + + Diaz + Sonia + S + + Department of Obstetrics, Hospital Universitario de Getafe, Getafe, Spain. + + + + Maiz + Nerea + N + + Maternal Fetal Medicine Unit, Department of Obstetrics, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona, Barcelona, Spain. + + + + Carreras + Elena + E + + Maternal Fetal Medicine Unit, Department of Obstetrics, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona, Barcelona, Spain. + + + + Suy + Anna + A + + Maternal Fetal Medicine Unit, Department of Obstetrics, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona, Barcelona, Spain. + + + + eng + + + ClinicalTrials.gov + + NCT03741179 + + + + + Journal Article + +
+ + United States + JAMA + 7501160 + 0098-7484 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 42 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809321 + 2801678 + 10.1001/jama.2023.0691 + + +
+ + + 36809332 + + 2023 + 02 + 22 + +
+ + 1538-3598 + + 329 + 7 + + 2023 + Feb + 21 + + + JAMA + JAMA + + Audio Highlights. + + e2215800 + + 10.1001/jama.2022.15800 + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + JAMA + 7501160 + 0098-7484 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 42 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809332 + 2801692 + 10.1001/jama.2022.15800 + + +
+ + + 36809336 + + 2023 + 02 + 22 + +
+ + 1813-9175 + + 2023 + + 2023 + Feb + 21 + + + Multimedia manual of cardiothoracic surgery : MMCTS + Multimed Man Cardiothorac Surg + + Chimney technique for a solitary pelvic kidney. + 10.1510/mmcts.2022.119 + + The combination of a solitary pelvic kidney and an abdominal aortic aneurysm is extremely rare. We demonstrate a chimney graft implant in a patient with a solitary pelvic kidney. A 63-year-old man was diagnosed with an abdominal aortic aneurysm found incidentally. Preoperative computed tomography illustrated a fusiform abdominal aortic aneurysm accompanying a solitary ectopic kidney in the pelvis with an aberrant renal artery. A bifurcated endograft was implanted, and a covered stent graft was placed into the renal artery using the chimney technique. Good patency of the chimney graft was documented with early postoperative and first month scans. To the best of our knowledge, this is the first report of the chimney technique used for a solitary pelvic kidney. + © The Author 2023. Published by MMCTS on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved. + + + + Ertugay + Serkan + S + + Ege University, School of Medicine, Department of Cardiovascular Surgery, Izmir, Türkiye. + + + + Posacioglu + Hakan + H + + Ege University, School of Medicine, Department of Cardiovascular Surgery, Izmir, Türkiye. + + + + Bozkaya + Halil + H + + Medicana Hospital, Department of Radiology, Izmir, Türkiye. + + + + Parildar + Mustafa + M + + Ege University, School of Medicine, Department. Of Radiology, Izmir, Türkiye. + + + + eng + + Video-Audio Media + + + 2023 + 02 + 21 + +
+ + England + Multimed Man Cardiothorac Surg + 101495626 + 1813-9175 + + IM + + Aneurysm + Aorta + Endovascular aortic repair + +
+ + + + 2023 + 2 + 22 + 13 + 42 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809336 + 10.1510/mmcts.2022.119 + + +
+ + + 36809331 + + 2023 + 02 + 22 + +
+ + 1538-3598 + + 329 + 7 + + 2023 + Feb + 21 + + + JAMA + JAMA + + Seasonal Variability of Disease. + + 598 + + 10.1001/jama.2022.15801 + eng + + Journal Article + +
+ + United States + JAMA + 7501160 + 0098-7484 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 42 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809331 + 2801690 + 10.1001/jama.2022.15801 + + +
+ + + 36809342 + + 2023 + 02 + 22 + +
+ + 1432-0932 + + + 2023 + Feb + 21 + + + European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society + Eur Spine J + + How to select the lowest instrumented vertebra in NF-1 non-dystrophic scoliosis. + 10.1007/s00586-023-07600-z + + To investigate lowest instrumented vertebra (LIV) selection strategy for neurofibromatosis type 1 (NF-1) non-dystrophic scoliosis. + Consecutive eligible subjects with NF-1 non-dystrophic scoliosis were included. All patients were followed up at least for 24 months. Enrolled patients with LIV in stable vertebra were divided into stable vertebra group (SV group), and the other patients with LIV above the stable vertebra were divided into above stable vertebra group (ASV group). Demographic data, operative data, preoperative and postoperative radiographic data, and clinical outcome were collected and analyzed. + There were 14 patients in SV group (ten males and four females, mean age 13.9 ± 4.1 years) and 14 patients in ASV group (nine males and five females, mean age 12.9 ± 3.5 years). The mean follow-up period was 31.7 ± 17.4 months for patients in SV group and 33.6 ± 17.4 months for patients in ASV group, respectively. No significant differences were found in demographic data between two groups. The coronal Cobb angle, C7-CSVL, AVT, LIVDA, LIV tilt and SRS-22 questionnaire outcome significantly improved at the final follow-up in both groups. However, significantly higher loss of correction rate and increasement of LIVDA were found in ASV group. Two patients (14.3%) in ASV group but none in SV group suffered adding-on phenomenon. + Although patients in both SV and ASV groups obtained improved therapeutic efficacy at final follow-up, the radiographic and clinical outcome seemed more likely to deteriorate in ASV group after surgery. The stable vertebra should be recommended as LIV for NF-1 non-dystrophic scoliosis. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Shao + Xiexiang + X + + Spine Center, Xinhua Hospital Affiliated to Shanghai Jiao Tong University Shanghai Jiao Tong University, Shanghai, 200092, China. + + + + Zhang + Tianyuan + T + + Spine Center, Xinhua Hospital Affiliated to Shanghai Jiao Tong University Shanghai Jiao Tong University, Shanghai, 200092, China. + + + + Yang + Jingfan + J + + Spine Center, Xinhua Hospital Affiliated to Shanghai Jiao Tong University Shanghai Jiao Tong University, Shanghai, 200092, China. + + + + Deng + Yaolong + Y + + Spine Center, Xinhua Hospital Affiliated to Shanghai Jiao Tong University Shanghai Jiao Tong University, Shanghai, 200092, China. + + + + Huang + Zifang + Z + + Department of Spine Surgery, Sun Yat-Sen University Third Affiliated Hospital, Guangzhou, 510630, China. + + + + Yang + Junlin + J + + Spine Center, Xinhua Hospital Affiliated to Shanghai Jiao Tong University Shanghai Jiao Tong University, Shanghai, 200092, China. yangjunlin@xinhuamed.com.cn. + + + + Sui + Wenyuan + W + + Spine Center, Xinhua Hospital Affiliated to Shanghai Jiao Tong University Shanghai Jiao Tong University, Shanghai, 200092, China. suiwenyuan@hotmail.com. + + + + eng + + + YG2021QN42 + The Medical-engineering Cross Fund of Rising Star Plan in Shanghai Jiao Tong University + + + + 82072519 + National Natural Science Foundation of China + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Eur Spine J + 9301980 + 0940-6719 + + IM + + Lowest instrumented vertebrae selection + Neurofibromatosis type 1 + Non-dystrophic scoliosis + Stable vertebra + +
+ + + + 2022 + 05 + 04 + + + 2023 + 02 + 09 + + + 2023 + 02 + 01 + + + 2023 + 2 + 22 + 13 + 42 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809342 + 10.1007/s00586-023-07600-z + 10.1007/s00586-023-07600-z + + + + Tamura R (2021) Current understanding of neurofibromatosis type 1, 2, and schwannomatosis. Int J Mol Sci. https://doi.org/10.3390/ijms22115850 + + 10.3390/ijms22115850 + 35008728 + 8745386 + + + + Yao Z, Li H, Zhang X, Li C, Qi X (2018) Incidence and risk factors for instrumentation-related complications after scoliosis surgery in pediatric patients with NF-1. Spine 43:1719–1724. https://doi.org/10.1097/BRS.0000000000002720 + + 10.1097/BRS.0000000000002720 + 29762338 + + + + Vitale MG, Guha A, Skaggs DL (2002) Orthopaedic manifestations of neurofibromatosis in children: an update. Clin Orthop Relat Res. https://doi.org/10.1097/00003086-200208000-00013 + + 10.1097/00003086-200208000-00013 + 12151887 + + + + Toro G, Santoro C, Ambrosio D, Landi G, Scilipoti M, Moretti A, Paoletta M, Liguori S, Schiavone Panni A, Picariello S, Iolascon G (2021) Natural history of scoliosis in children with NF1: an observation study. Healthcare. https://doi.org/10.3390/healthcare9070881 + + 10.3390/healthcare9070881 + 34356257 + 8303287 + + + + Park BJ, Hyun SJ, Wui SH, Jung JM, Kim KJ, Jahng TA (2020) Surgical outcomes and complications following all posterior approach for spinal deformity associated with neurofibromatosis type-1. J Korean Neurosurg Soc 63:738–746. https://doi.org/10.3340/jkns.2019.0218 + + 10.3340/jkns.2019.0218 + 32512989 + 7671774 + + + + Shao X, Sui W, Deng Y, Yang J, Chen J, Yang J (2022) How to select the lowest instrumented vertebra in Lenke 5/6 adolescent idiopathic scoliosis patients with derotation technique. Eur Spine J 31:996–1005. https://doi.org/10.1007/s00586-021-07040-7 + + 10.1007/s00586-021-07040-7 + 34743244 + + + + Kim HW, Weinstein SL (1997) Spine update. The management of scoliosis in neurofibromatosis. Spine 22:2770–2776. https://doi.org/10.1097/00007632-199712010-00014 + + 10.1097/00007632-199712010-00014 + 9431613 + + + + Lyu Q, Zhou C, Song Y, Liu L, Wang L, Zhou Z (2017) Does spinal deformity correction of non-dystrophic scoliosis in neurofibromatosis type I with one-stage posterior pedicle screw technique produce outcomes similar to adolescent idiopathic scoliosis? Spine J 17:1850–1858. https://doi.org/10.1016/j.spinee.2017.06.011 + + 10.1016/j.spinee.2017.06.011 + 28645674 + + + + Kurucan E, Bernstein DN, Thirukumaran C, Jain A, Menga EN, Rubery PT, Mesfin A (2018) National trends in spinal fusion surgery for neurofibromatosis. Spine Deform 6:712–718. https://doi.org/10.1016/j.jspd.2018.03.012 + + 10.1016/j.jspd.2018.03.012 + 30348349 + + + + Sun Z, Qiu G, Zhao Y, Wang Y, Zhang J, Shen J (2014) Lowest instrumented vertebrae selection for selective posterior fusion of moderate thoracolumbar/lumbar idiopathic scoliosis: lower-end vertebra or lower-end vertebra+1? Eur Spine J 23:1251–1257. https://doi.org/10.1007/s00586-014-3276-0 + + 10.1007/s00586-014-3276-0 + 24664427 + + + + Rose PS, Lenke LG (2007) Classification of operative adolescent idiopathic scoliosis: treatment guidelines. Orthop Clin North Am 38:521–529. https://doi.org/10.1016/j.ocl.2007.06.001 + + 10.1016/j.ocl.2007.06.001 + 17945131 + + + + Zhuang Q, Zhang J, Wang S, Yang Y, Lin G (2021) How to select the lowest instrumented vertebra in Lenke type 5 adolescent idiopathic scoliosis patients? Spine J 21:141–149. https://doi.org/10.1016/j.spinee.2020.08.006 + + 10.1016/j.spinee.2020.08.006 + 32805433 + + + + Shufflebarger HL (1989) Cotrel-Dubousset instrumentation in neurofibromatosis spinal problems. Clin Orthop Relat Res 24–28 + + + Crawford AH (1986) Neurofibromatosis in children. Acta Orthop Scand Suppl 218:1–60 + + 3083645 + + + + Yang N, Luo M, Zhao S, Wang W, Xia L (2020) Morphological differences between the pedicles in nondystrophic scoliosis secondary to neurofibromatosis type 1 and those in adolescent idiopathic scoliosis. World Neurosurg 144:e9–e14. https://doi.org/10.1016/j.wneu.2020.06.036 + + 10.1016/j.wneu.2020.06.036 + 32540291 + + + + Tsirikos AI, Saifuddin A, Noordeen MH (2005) Spinal deformity in neurofibromatosis type-1: diagnosis and treatment. Eur Spine J 14:427–439. https://doi.org/10.1007/s00586-004-0829-7 + + 10.1007/s00586-004-0829-7 + 15712001 + 3454658 + + + + Crawford AH (1989) Pitfalls of spinal deformities associated with neurofibromatosis in children. Clin Orthop Relat Res 29–42 + + + Durrani AA, Crawford AH, Chouhdry SN, Saifuddin A, Morley TR (2000) Modulation of spinal deformities in patients with neurofibromatosis type 1. Spine 25:69–75. https://doi.org/10.1097/00007632-200001010-00013 + + 10.1097/00007632-200001010-00013 + 10647163 + + + + Jett K, Friedman JM (2010) Clinical and genetic aspects of neurofibromatosis 1. Genet Med 12:1–11. https://doi.org/10.1097/GIM.0b013e3181bf15e3 + + 10.1097/GIM.0b013e3181bf15e3 + 20027112 + + + + Lykissas MG, Schorry EK, Crawford AH, Gaines S, Rieley M, Jain VV (2013) Does the presence of dystrophic features in patients with type 1 neurofibromatosis and spinal deformities increase the risk of surgery? Spine 38:1595–1601. https://doi.org/10.1097/BRS.0b013e31829a7779 + + 10.1097/BRS.0b013e31829a7779 + 23680833 + + + + Wang Z, Liu Y (2010) Research update and recent developments in the management of scoliosis in neurofibromatosis type 1. Orthopedics 33:335–341. https://doi.org/10.3928/01477447-20100329-20 + + 10.3928/01477447-20100329-20 + 20507037 + + + + Crawford AH, Parikh S, Schorry EK, Von Stein D (2007) The immature spine in type-1 neurofibromatosis. J Bone Jt Surg Am 89(Suppl 1):123–142. https://doi.org/10.2106/JBJS.F.00836 + + 10.2106/JBJS.F.00836 + + + + Panjabi MM, Takata K, Goel V, Federico D, Oxland T, Duranceau J, Krag M (1991) Thoracic human vertebrae. Quantitative three-dimensional anatomy. Spine 16:888–901. https://doi.org/10.1097/00007632-199108000-00006 + + 10.1097/00007632-199108000-00006 + 1948374 + + + + Liu Z, Qiu Y, Li Y, Zhao ZH, Wang B, Zhu F, Yu Y, Sun X, Zhu ZZ (2017) Clinical application of three-dimensional O-arm navigation system in treating patients with dystrophic scoliosis secondary to neurofibromatosis type I. Zhonghua Wai Ke Za Zhi 55:186–191. https://doi.org/10.3760/cma.j.issn.0529-5815.2017.03.005 + + 10.3760/cma.j.issn.0529-5815.2017.03.005 + 28241719 + + + + Wang Z, Fu C, Leng J, Qu Z, Xu F, Liu Y (2015) Treatment of dystrophic scoliosis in neurofibromatosis Type 1 with one-stage posterior pedicle screw technique. Spine J 15:587–595. https://doi.org/10.1016/j.spinee.2014.10.014 + + 10.1016/j.spinee.2014.10.014 + 25452011 + + + + Deng A, Zhang HQ, Tang MX, Liu SH, Wang YX, Gao QL (2017) Posterior-only surgical correction of dystrophic scoliosis in 31 patients with neurofibromatosis Type 1 using the multiple anchor point method. J Neurosurg Pediatr 19:96–101. https://doi.org/10.3171/2016.7.PEDS16125 + + 10.3171/2016.7.PEDS16125 + 27739946 + + + + Marrache M, Suresh KV, Miller DJ, Hwang S, Schorry EK, Rios JJ, Sponseller PD (2021) Early-onset spinal deformity in neurofibromatosis type 1: natural history, treatment, and imaging surveillance. JBJS Rev. https://doi.org/10.2106/JBJS.RVW.20.00285 + + 10.2106/JBJS.RVW.20.00285 + 34297709 + + + + Hu Z, Liu Z, Qiu Y, Xu L, Yan H, Zhu Z (2016) Morphological differences in the vertebrae of scoliosis secondary to neurofibromatosis type 1 with and without paraspinal neurofibromas. Spine 41:598–602. https://doi.org/10.1097/BRS.0000000000001455 + + 10.1097/BRS.0000000000001455 + 26780616 + + + + +
+ + + 36809333 + + 2023 + 02 + 22 + +
+ + 1538-3598 + + 329 + 7 + + 2023 + Feb + 21 + + + JAMA + JAMA + + Biomarkers and the Risk of Preeclampsia. + + 539-541 + + 10.1001/jama.2022.24906 + + + Emeruwa + Ukachi N + UN + + Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego, La Jolla. + + + + Gyamfi-Bannerman + Cynthia + C + + Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego, La Jolla. + + + + Laurent + Louise C + LC + + Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego, La Jolla. + + + + eng + + Journal Article + +
+ + United States + JAMA + 7501160 + 0098-7484 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 42 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809333 + 2801702 + 10.1001/jama.2022.24906 + + +
+ + + 36809344 + + 2023 + 02 + 22 + +
+ + 1365-2346 + + + 2023 + Feb + 10 + + + European journal of anaesthesiology + Eur J Anaesthesiol + + Global Anaesthesia (Oxford specialist handbook in anaesthesia). + 10.1097/EJA.0000000000001801 + eng + + Journal Article + + + 2023 + 02 + 10 + +
+ + England + Eur J Anaesthesiol + 8411711 + 0265-0215 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 42 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809344 + 10.1097/EJA.0000000000001801 + 00003643-990000000-00065 + + +
+ + + 36809347 + + 2023 + 02 + 22 + +
+ + 1460-2105 + + + 2023 + Feb + 21 + + + Journal of the National Cancer Institute + J Natl Cancer Inst + + Use of menopausal hormone therapy and ovarian cancer risk in a French cohort study. + djad035 + 10.1093/jnci/djad035 + + Epidemiological studies have found that menopausal hormone therapy (MHT) use is associated with an increased ovarian cancer risk. However, whether different MHT types confer the same level of risk is unclear. We estimated the associations between different MHT types and the risk of ovarian cancer in a prospective cohort. + The study population included 75,606 postmenopausal women from the E3N cohort. Exposure to MHT was identified from self-reports in biennial questionnaires between 1992 and 2004 and from drug claim data matched to the cohort between 2004 and 2014. Hazard ratios (HR) and 95% confidence intervals (CI) of ovarian cancer were estimated using multivariable Cox proportional hazards models with MHT as a time-varying exposure. Tests of statistical significance were 2-sided. + Over an average 15.3 years follow-up, 416 ovarian cancers were diagnosed. HRs of ovarian cancer associated with ever use of estrogens combined with progesterone or dydrogesterone and ever use of estrogens combined with other progestagen were equal to 1.28 (95%CI 1.04 to 1.57) and 0.81 (0.65 to 1.00), respectively (p-homogeneity = 0.003), compared with never use. The HR for unopposed estrogen use was 1.09 (0.82 to 1.46). We found no trend according to duration of use or time since last use except for estrogens combined with progesterone/dydrogesterone which showed decreasing risk with increasing time since last use. + Different MHT types may impact ovarian cancer risk differentially. The possibility that MHT containing progestagens other than progesterone or dydrogesterone may confer some protection should be evaluated in other epidemiological studies. + © The Author(s) 2023. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com. + + + + Fournier + Agnès + A + + Université Paris-Saclay, Inserm, Institut Gustave Roussy, "Exposome, heredity, cancer and health" team, Centre for Epidemiology and Population Health (CESP UMR 1018), Villejuif, 94805, France. + + + + Cairat + Manon + M + + Université Paris-Saclay, Inserm, Institut Gustave Roussy, "Exposome, heredity, cancer and health" team, Centre for Epidemiology and Population Health (CESP UMR 1018), Villejuif, 94805, France. + + + + Severi + Gianluca + G + + Université Paris-Saclay, Inserm, Institut Gustave Roussy, "Exposome, heredity, cancer and health" team, Centre for Epidemiology and Population Health (CESP UMR 1018), Villejuif, 94805, France. + + + Department of Statistics, Computer Science and Applications « G. Parenti », University of Florence, Italy. + + + + Gunter + Marc J + MJ + + Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France. + + + + Rinaldi + Sabina + S + + Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France. + + + + Dossus + Laure + L + + Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + J Natl Cancer Inst + 7503089 + 0027-8874 + + IM +
+ + + + 2022 + 11 + 28 + + + 2023 + 02 + 08 + + + 2023 + 02 + 13 + + + 2023 + 2 + 22 + 13 + 43 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809347 + 7049521 + 10.1093/jnci/djad035 + + +
+ + + 36809338 + + 2023 + 02 + 22 + +
+ + 2047-4881 + + + 2023 + Feb + 21 + + + European journal of preventive cardiology + Eur J Prev Cardiol + + Reference values of aerobic fitness in the contemporary paediatric population. + zwad054 + 10.1093/eurjpc/zwad054 + + There has been a growing interest in the use of markers of aerobic physical fitness (VO2max assessed by cardiopulmonary exercise testing (CPET)) in the follow-up of paediatric chronic diseases. The dissemination of CPET in paediatrics requires valid paediatric VO2max reference values to define the upper and lower normal limits. This study aimed to establish VO2max reference Z-scores values, from a large cohort of children representative of the contemporary paediatric population, including those with extreme weights. + In this cross-sectional study, 909 children aged 5 to 18-years-old from the general French population (development cohort), and 232 children from the general German and US populations (validation cohort) underwent a CPET, following the guidelines on high-quality CPET assessment. Linear, quadratic, and polynomial mathematical regression equations were applied to identify the best VO2max Z-score model. Predicted and observed VO2max values using the VO2maxZ-score model, and the existing linear equations were compared, in both development and validation cohorts. For both sexes, the mathematical model using natural logarithms of VO2max, height, and BMI was the best fit for the data. This Z-score model could be applied to normal and extreme weights and was more reliable than the existing linear equations, in both internal and external validity analyses (https://play.google.com/store/apps/details?id=com.d2l.zscore). + This study established reference Z-score values for paediatric cycloergometer VO2max using a logarithmic function of VO2max, height and BMI, applicable to normal and extreme weights. Providing Z-scores to assess aerobic fitness in the paediatric population should be useful in the follow-up of children with chronic diseases. + © The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. + + + + Gavotto + Arthur + A + 0000-0001-6485-7634 + + Paediatric and Congenital Cardiology Department, M3C Regional Reference CHD Centre, Montpellier University Hospital, Montpellier, France. + + + PhyMedExp, CNRS, INSERM, University of Montpellier, Montpellier, France. + + + + Mura + Thibault + T + + INSERM, University of Montpellier, U1061, Neuropsychiatry: Epidemiological and Clinical Research, Montpellier, France. + + + Department of Biostatistics, Clinical Epidemiology, Public Health, and Innovation in Methodology, Nimes University Hospital, University of Montpellier, Nimes, France. + + + + Rhodes + Jonathan + J + + Department of Cardiology, Boston Children's Hospital, Boston, USA. + + + + Yin + Suellen Moli + SM + + Department of Cardiology, Boston Children's Hospital, Boston, USA. + + + + Hager + Alfred + A + 0000-0002-2481-2017 + + Clinic for Paediatric Cardiology and Congenital Heart Diseases, German Heart Centre, Munich, Germany. + + + + Hock + Julia + J + + Clinic for Paediatric Cardiology and Congenital Heart Diseases, German Heart Centre, Munich, Germany. + + + + Guillaumont + Sophie + S + + Paediatric and Congenital Cardiology Department, M3C Regional Reference CHD Centre, Montpellier University Hospital, Montpellier, France. + + + Paediatric Cardiology and Rehabilitation Unit, St-Pierre Institute, Palavas-Les-Flots, France. + + + + Vincenti + Marie + M + + Paediatric and Congenital Cardiology Department, M3C Regional Reference CHD Centre, Montpellier University Hospital, Montpellier, France. + + + Paediatric Cardiology and Rehabilitation Unit, St-Pierre Institute, Palavas-Les-Flots, France. + + + + De La Villeon + Gregoire + G + + Paediatric and Congenital Cardiology Department, M3C Regional Reference CHD Centre, Montpellier University Hospital, Montpellier, France. + + + Paediatric Cardiology and Rehabilitation Unit, St-Pierre Institute, Palavas-Les-Flots, France. + + + + Requirand + Anne + A + + Paediatric and Congenital Cardiology Department, M3C Regional Reference CHD Centre, Montpellier University Hospital, Montpellier, France. + + + + Picot + Marie-Christine + MC + + Clinical Research and Epidemiology Unit, Montpellier University Hospital, INSERM-CIC 1411, Clinical Investigation Centre, University of Montpellier, Montpellier, France. + + + + Huguet + Helena + H + + Clinical Research and Epidemiology Unit, Montpellier University Hospital, INSERM-CIC 1411, Clinical Investigation Centre, University of Montpellier, Montpellier, France. + + + + Souilla + Luc + L + + PhyMedExp, CNRS, INSERM, University of Montpellier, Montpellier, France. + + + + Moreau + Johan + J + + Paediatric and Congenital Cardiology Department, M3C Regional Reference CHD Centre, Montpellier University Hospital, Montpellier, France. + + + PhyMedExp, CNRS, INSERM, University of Montpellier, Montpellier, France. + + + + Matecki + Stefan + S + + Paediatric and Congenital Cardiology Department, M3C Regional Reference CHD Centre, Montpellier University Hospital, Montpellier, France. + + + PhyMedExp, CNRS, INSERM, University of Montpellier, Montpellier, France. + + + + Amedro + Pascal + P + 0000-0003-3649-0294 + + Paediatric and Congenital Cardiology Department, M3C National Reference Centre, Bordeaux University Hospital, Bordeaux, France. + + + IHU Liryc, Electrophysiology and Heart Modelling Institute, INSERM 1045, Bordeaux University Foundation, Pessac, France. + + + + eng + + + ClinicalTrials.gov + + NCT04876209 + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Eur J Prev Cardiol + 101564430 + 2047-4873 + + IM + + The dissemination of CPET in paediatrics requires valid paediatric VO2max reference values to define the upper and lower normal limits. Existing linear equations may not be appropriate for the contemporary paediatric population, especially for extreme weights. + For both sexes, the mathematical model using natural logarithms of VO2max, height, and BMI was the best fit for the data. This Z-score model could be applied to normal and extreme weights and was more reliable than linear equations. + Providing Z-scores to assess aerobic fitness in the paediatric population should be useful in the follow-up of children with chronic diseases. + ClinicalTrials.gov NCT04876209. + + + VO2 + Z-score + cardiopulmonary exercise test + obesity + paediatrics + +
+ + + + 2022 + 10 + 06 + + + 2022 + 12 + 21 + + + 2023 + 02 + 20 + + + 2023 + 2 + 22 + 13 + 42 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809338 + 7049938 + 10.1093/eurjpc/zwad054 + + +
+ + + 36809341 + + 2023 + 02 + 22 + +
+ + 1530-8898 + + + 2023 + Feb + 20 + + + Journal of cognitive neuroscience + J Cogn Neurosci + + Dimension-wise Sequential Update for Learning a Multidimensional Environment in Human. + + 1-15 + + 10.1162/jocn_a_01975 + + When confronted with multidimensional environment problems, humans may need to jointly update multiple state-action-outcome associations across various dimensions. Computational modeling of human behavior and neural activities suggests that such updates are implemented based upon Bayesian update principle. However, it is unclear whether humans perform these updates individually or sequentially. If the update occurs sequentially, the order in which the associations are updated matters and can influence the updated results. To address this question, we tested a few computational models with different update orders using both human behavior and EEG data. Our results indicated that a model undertaking dimension-wise sequential updates was the best fit to human behavior. In this model, ordering the dimensions was decided using entropy, which indexed the uncertainty of associations. Simultaneously collected EEG data revealed evoked potentials that were correlated to the proposed timing of this model. These findings provide new insights into the temporal processes underlying Bayesian update in multidimensional environments. + © 2023 Massachusetts Institute of Technology. + + + + Higashi + Hiroshi + H + 0000-0001-8880-3411 + + Kyoto University, Japan. + + + + eng + + Journal Article + + + 2023 + 02 + 20 + +
+ + United States + J Cogn Neurosci + 8910747 + 0898-929X + + IM +
+ + + + 2023 + 2 + 22 + 13 + 42 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809341 + 114942 + 10.1162/jocn_a_01975 + + +
+ + + 36809337 + + 2023 + 02 + 22 + +
+ + 1929-0748 + + 12 + + 2023 + Feb + 21 + + + JMIR research protocols + JMIR Res Protoc + + Developing Early Markers of Cognitive Decline and Dementia Derived From Survey Response Behaviors: Protocol for Analyses of Preexisting Large-scale Longitudinal Data. + + e44627 + + 10.2196/44627 + + Accumulating evidence shows that subtle alterations in daily functioning are among the earliest and strongest signals that predict cognitive decline and dementia. A survey is a small slice of everyday functioning; nevertheless, completing a survey is a complex and cognitively demanding task that requires attention, working memory, executive functioning, and short- and long-term memory. Examining older people's survey response behaviors, which focus on how respondents complete surveys irrespective of the content being sought by the questions, may represent a valuable but often neglected resource that can be leveraged to develop behavior-based early markers of cognitive decline and dementia that are cost-effective, unobtrusive, and scalable for use in large population samples. + This paper describes the protocol of a multiyear research project funded by the US National Institute on Aging to develop early markers of cognitive decline and dementia derived from survey response behaviors at older ages. + Two types of indices summarizing different aspects of older adults' survey response behaviors are created. Indices of subtle reporting mistakes are derived from questionnaire answer patterns in a number of population-based longitudinal aging studies. In parallel, para-data indices are generated from computer use behaviors recorded on the backend server of a large web-based panel study known as the Understanding America Study (UAS). In-depth examinations of the properties of the created questionnaire answer pattern and para-data indices will be conducted for the purpose of evaluating their concurrent validity, sensitivity to change, and predictive validity. We will synthesize the indices using individual participant data meta-analysis and conduct feature selection to identify the optimal combination of indices for predicting cognitive decline and dementia. + As of October 2022, we have identified 15 longitudinal ageing studies as eligible data sources for creating questionnaire answer pattern indices and obtained para-data from 15 UAS surveys that were fielded from mid-2014 to 2015. A total of 20 questionnaire answer pattern indices and 20 para-data indices have also been identified. We have conducted a preliminary investigation to test the utility of the questionnaire answer patterns and para-data indices for the prediction of cognitive decline and dementia. These early results are based on only a subset of indices but are suggestive of the findings that we anticipate will emerge from the planned analyses of multiple behavioral indices derived from many diverse studies. + Survey response behaviors are a relatively inexpensive data source, but they are seldom used directly for epidemiological research on cognitive impairment at older ages. This study is anticipated to develop an innovative yet unconventional approach that may complement existing approaches aimed at the early detection of cognitive decline and dementia. + DERR1-10.2196/44627. + ©Haomiao Jin, Doerte U Junghaenel, Bart Orriens, Pey-Jiuan Lee, Stefan Schneider. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 21.02.2023. + + + + Jin + Haomiao + H + https://orcid.org/0000-0001-8908-1959 + + School of Health Sciences, University of Surrey, Guildford, United Kingdom. + + + Center for Economic and Social Research, University of Southern California, Los Angeles, CA, United States. + + + + Junghaenel + Doerte U + DU + https://orcid.org/0000-0002-7733-571X + + Center for Economic and Social Research, University of Southern California, Los Angeles, CA, United States. + + + Center for Self-Report Sciences, University of Southern California, Los Angeles, CA, United States. + + + Department of Psychology, University of Southern California, Los Angeles, CA, United States. + + + + Orriens + Bart + B + https://orcid.org/0000-0002-1304-7735 + + Center for Economic and Social Research, University of Southern California, Los Angeles, CA, United States. + + + + Lee + Pey-Jiuan + PJ + https://orcid.org/0000-0001-6163-2325 + + Center for Economic and Social Research, University of Southern California, Los Angeles, CA, United States. + + + + Schneider + Stefan + S + https://orcid.org/0000-0002-4562-0524 + + Center for Economic and Social Research, University of Southern California, Los Angeles, CA, United States. + + + Center for Self-Report Sciences, University of Southern California, Los Angeles, CA, United States. + + + Department of Psychology, University of Southern California, Los Angeles, CA, United States. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Canada + JMIR Res Protoc + 101599504 + 1929-0748 + + + dementia + early markers + epidemiology + mild cognitive impairment + survey response behaviors + +
+ + + + 2022 + 11 + 27 + + + 2023 + 01 + 24 + + + 2023 + 01 + 10 + + + 2023 + 2 + 22 + 13 + 42 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809337 + v12i1e44627 + 10.2196/44627 + + +
+ + + 36809343 + + 2023 + 02 + 22 + +
+ + 1432-0932 + + + 2023 + Feb + 21 + + + European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society + Eur Spine J + + Sagittal alignment cut-off values for predicting future fall-related fractures in community-dwelling osteoporotic women. + 10.1007/s00586-023-07599-3 + + Determining the optimal cut-off value of sagittal alignment for detecting osteoporotic patients at high risk for fall-related fractures is essential for understanding fracture risk and informing clinicians and physical therapists. We determined the optimal cut-off value of sagittal alignment for detecting osteoporotic patients at high risk for fall-related fractures in this study. + In the retrospective cohort study, we enrolled a total of 255 women aged ≥ 65 years who visited an outpatient osteoporosis clinic. We measured participants' bone mineral density and sagittal alignment, including sagittal vertical axis (SVA), pelvic tilt, thoracic kyphosis, pelvic incidence, lumbar lordosis, global tilt, and gap score at the initial visit. The cut-off value for sagittal alignment that was significantly associated with fall-related fractures was calculated after using multivariate Cox proportional hazards regression analysis. + Ultimately, 192 patients were included in the analysis. After a mean follow-up of 3.0 years, 12.0% (n = 23) had fractures due to falls. Multivariate Cox regression analysis confirmed that SVA (hazard ratio [HR] = 1.022, 95% confidence interval [CI] = 1.005-1.039) was the only independent predictor of fall-related fracture occurrence. The predictive ability of SVA for the occurrence of fall-related fractures was moderate (area under the curve [AUC] = 0.728, 95% CI = 0.623-0.834), with a cut-off value of 100 mm for SVA. SVA classified by cut-off value was also associated with an increased risk of developing fall-related fractures (HR = 17.002, 95% CI = 4.102-70.475). + We found that assessing the cut-off value of sagittal alignment would be useful information in understanding fracture risk in postmenopausal older women. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Asahi + Ryoma + R + http://orcid.org/0000-0002-7475-795X + + School of Health Sciences, Japan University of Health Sciences, 2-555, Hirasuka, Satte City, Saitama, 340-0145, Japan. r-asahi@jhsu.ac.jp. + + + + Nakamura + Yutaka + Y + + Saitama Spine Center, Higashi Saitama General Hospital, 517-5, Yoshino, Satte City, Saitama, 340-0153, Japan. + + + + Koike + Yoshinao + Y + + Saitama Spine Center, Higashi Saitama General Hospital, 517-5, Yoshino, Satte City, Saitama, 340-0153, Japan. + + + + Kanai + Masayoshi + M + + Saitama Spine Center, Higashi Saitama General Hospital, 517-5, Yoshino, Satte City, Saitama, 340-0153, Japan. + + + + Yuguchi + Satoshi + S + + School of Health Sciences, Japan University of Health Sciences, 2-555, Hirasuka, Satte City, Saitama, 340-0145, Japan. + + + + Kamo + Tomohiko + T + + Department of Rehabilitation, Gunma Paz University, 1-7-1 Tonyamachi, Takasaki City, Gunma, 370-0006, Japan. + + + + Azami + Masato + M + + School of Health Sciences, Japan University of Health Sciences, 2-555, Hirasuka, Satte City, Saitama, 340-0145, Japan. + + + + Ogihara + Hirofumi + H + + Division of Physical Therapy, Department of Rehabilitation, Faculty of Health Sciences, Nagano University of Health and Medicine, 11-1, Imaihara, Kawanakajima-Machi, Nagano City, Nagano, 381-2227, Japan. + + + + Asano + Satoshi + S + + Saitama Spine Center, Higashi Saitama General Hospital, 517-5, Yoshino, Satte City, Saitama, 340-0153, Japan. + + + + eng + + + JP20K19221 + Japan Society for the Promotion of Science + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Eur Spine J + 9301980 + 0940-6719 + + IM + + Cut-off value + Fall-related fractures + Osteoporotic women + Sagittal alignment + +
+ + + + 2022 + 06 + 24 + + + 2023 + 02 + 09 + + + 2023 + 01 + 12 + + + 2023 + 2 + 22 + 13 + 42 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809343 + 10.1007/s00586-023-07599-3 + 10.1007/s00586-023-07599-3 + + + + Lubitz J, Cai L, Kramarow E, Lentzner H (2003) Health, life expectancy, and health care spending among the elderly. N Engl J Med 349:1048–1055. https://doi.org/10.1056/nejmsa020614 + + 10.1056/nejmsa020614 + 12968089 + + + + Odén A, McCloskey EV, Kanis JA et al (2015) Burden of high fracture probability worldwide: secular increases 2010–2040. Osteoporos Int 26:2243–2248. https://doi.org/10.1007/s00198-015-3154-6 + + 10.1007/s00198-015-3154-6 + 26018089 + + + + Orimo H, Yaegashi Y, Hosoi T et al (2016) Hip fracture incidence in Japan: estimates of new patients in 2012 and 25-year trends. Osteoporos Int 27:1777–1784. https://doi.org/10.1007/s00198-015-3464-8 + + 10.1007/s00198-015-3464-8 + 26733376 + 4873530 + + + + Horii M, Fujiwara H, Ikeda T et al (2013) Urban versus rural differences in the occurrence of hip fractures in Japan’s Kyoto prefecture during 2008–2010: a comparison of femoral neck and trochanteric fractures. BMC Musculoskelet Disord 25(14):304. https://doi.org/10.1186/1471-2474-14-304 + + 10.1186/1471-2474-14-304 + + + + Johnell O, Kanis JA (2006) An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int 17:1726–1733. https://doi.org/10.1007/s00198-006-0172-4 + + 10.1007/s00198-006-0172-4 + 16983459 + + + + Sambrook PN, Cameron ID, Chen JS et al (2007) Influence of fall related factors and bone strength on fracture risk in the frail elderly. Osteoporos Int 18:603–610. https://doi.org/10.1007/s00198-006-0290-z + + 10.1007/s00198-006-0290-z + 17216131 + + + + Tiedemann A, Shimada H, Sherrington C et al (2008) The comparative ability of eight functional mobility tests for predicting falls in community-dwelling older people. Age Ageing 37:430–435. https://doi.org/10.1093/ageing/afn100 + + 10.1093/ageing/afn100 + 18487264 + + + + Nevitt MC, Cummings SR, Kidd S, Black D (1989) Risk factors for recurrent nonsyncopal falls: a prospective study. JAMA J Am Med Assoc 261:2663–2668. https://doi.org/10.1001/jama.1989.03420180087036 + + 10.1001/jama.1989.03420180087036 + + + + Barrey C, Roussouly P, Le Huec JC et al (2013) Compensatory mechanisms contributing to keep the sagittal balance of the spine. Eur Spine J 22:834–841. https://doi.org/10.1007/s00586-013-3030-z + + 10.1007/s00586-013-3030-z + 3830026 + + + + Miyakoshi N, Kudo D, Hongo M et al (2017) Comparison of spinal alignment, muscular strength, and quality of life between women with postmenopausal osteoporosis and healthy volunteers. Osteoporos Int 28:3153–3160. https://doi.org/10.1007/s00198-017-4184-z + + 10.1007/s00198-017-4184-z + 28785980 + + + + Asahi R, Nakamura Y, Kanai M et al (2022) Association with sagittal alignment and osteoporosis-related fractures in outpatient women with osteoporosis. Osteoporos Int 33:1275–1284. https://doi.org/10.1007/s00198-021-06282-x + + 10.1007/s00198-021-06282-x + 35091788 + + + + Baek SW, Kim C, Chang H (2015) The relationship between the spinopelvic balance and the incidence of adjacent vertebral fractures following percutaneous vertebroplasty. Osteoporos Int 26:1507–1513. https://doi.org/10.1007/s00198-014-3021-x + + 10.1007/s00198-014-3021-x + 25619632 + + + + Schwab F, Patel A, Ungar B et al (2010) Adult spinal deformity-postoperative standing imbalance: How much can you tolerate? An overview of key parameters in assessing alignment and planning corrective surgery. Spine (Phila Pa 1976) 35:2224–2231. https://doi.org/10.1097/BRS.0b013e3181ee6bd4 + + 10.1097/BRS.0b013e3181ee6bd4 + 21102297 + + + + Yurube T, Ito M, Takeoka T et al (2019) Possible improvement of the sagittal spinopelvic alignment and balance through “locomotion training” exercises in patients with “locomotive syndrome”: a literature review. Adv Orthop 2019:1–7. https://doi.org/10.1155/2019/6496901 + + 10.1155/2019/6496901 + + + + Boseker EH, Moe JH, Winter RB, Koop SE (2000) Determination of “normal” thoracic kyphosis: a roentgenographic study of 121 “normal” children. J Pediatr Orthop 20:796–798. https://doi.org/10.1097/01241398-200011000-00019 + + 10.1097/01241398-200011000-00019 + 11097257 + + + + Faro FD, Marks MC, Pawelek J, Newton PO (2004) Evaluation of a functional position for lateral radiograph acquisition in adolescent idiopathic scoliosis. Spine (Phila Pa 1976) 29:2284–2289. https://doi.org/10.1097/01.brs.0000142224.46796.a7 + + 10.1097/01.brs.0000142224.46796.a7 + 15480143 + + + + Pan C, Wang G, Li Y et al (2021) Predictive model of global tilt (GT) determined by individual thoracic kyphosis, lumbar lordosis and pelvic incidence in the human degenerative spine. Eur Spine J 30:3191–3199. https://doi.org/10.1007/s00586-021-06947-5 + + 10.1007/s00586-021-06947-5 + 34331586 + + + + Obeid I, Boissière L, Yilgor C et al (2016) Global tilt: a single parameter incorporating spinal and pelvic sagittal parameters and least affected by patient positioning. Eur Spine J 25:3644–3649. https://doi.org/10.1007/s00586-016-4649-3 + + 10.1007/s00586-016-4649-3 + 27323962 + + + + Boissière L, Takemoto M, Bourghli A et al (2017) Global tilt and lumbar lordosis index: two parameters correlating with health-related quality of life scores—but how do they truly impact disability? Spine J 17:480–488. https://doi.org/10.1016/j.spinee.2016.10.013 + + 10.1016/j.spinee.2016.10.013 + 27815217 + + + + Wegner AM, Iyer S, Lenke LG et al (2020) Global alignment and proportion (GAP) scores in an asymptomatic, nonoperative cohort: a divergence of age-adjusted and pelvic incidence-based alignment targets. Eur Spine J 29:2362–2367. https://doi.org/10.1007/s00586-020-06474-9 + + 10.1007/s00586-020-06474-9 + 32488438 + + + + Yilgor C, Sogunmez N, Boissiere L et al (2017) Global alignment and proportion (GAP) score: development and validation of a new method of analyzing spinopelvic alignment to predict mechanical complications after adult spinal deformity surgery. J Bone Jt Surg Am 99:1661–1672. https://doi.org/10.2106/JBJS.16.01594 + + 10.2106/JBJS.16.01594 + + + + DeLong ER, DeLong DM, Clarke-Pearson DL (1988) Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics 44:837. https://doi.org/10.2307/2531595 + + 10.2307/2531595 + 3203132 + + + + Jiang X, Westermann LB, Galleo GV et al (2013) Age as a predictor of osteoporotic fracture compared with current risk-prediction models. Obstet Gynecol 122:1040–1046. https://doi.org/10.1097/AOG.0b013e3182a7e29b + + 10.1097/AOG.0b013e3182a7e29b + 24104773 + + + + Kung AWC, Ho AYY, Ben SW et al (2003) Comparison of a simple clinical risk index and quantitative bone ultrasound for identifying women at increased risk of osteoporosis. Osteoporos Int 14:716–721. https://doi.org/10.1007/s00198-003-1428-x + + 10.1007/s00198-003-1428-x + 12897978 + + + + Michalski AS, Besler BA, Burt LA, Boyd SK (2021) Opportunistic CT screening predicts individuals at risk of major osteoporotic fracture. Osteoporos Int 32:1639–1649. https://doi.org/10.1007/s00198-021-05863-0 + + 10.1007/s00198-021-05863-0 + 33566138 + + + + Schwab FJ, Blondel B, Bess S et al (2013) Radiographical spinopelvic parameters and disability in the setting of adult spinal deformity: a prospective multicenter analysis. Spine Phila Pa (1976) 38:803–812. https://doi.org/10.1097/BRS.0b013e318292b7b9 + + 10.1097/BRS.0b013e318292b7b9 + + + + Imagama S, Ito Z, Wakao N et al (2013) Influence of spinal sagittal alignment, body balance, muscle strength, and physical ability on falling of middle-aged and elderly males. Eur Spine J 22:1346–1353. https://doi.org/10.1007/s00586-013-2721-9 + + 10.1007/s00586-013-2721-9 + 23443680 + 3676567 + + + + Bess S, Line B, Fu KM et al (2016) The health impact of symptomatic adult spinal deformity: Comparison of deformity types to United States population norms and chronic diseases. Spine Phila Pa (1976) 41:224–233. https://doi.org/10.1097/BRS.0000000000001202 + + 10.1097/BRS.0000000000001202 + 26571174 + + + + Hasegawa K, Okamoto M, Hatsushikano S et al (2016) Normative values of spino-pelvic sagittal alignment, balance, age, and health-related quality of life in a cohort of healthy adult subjects. Eur Spine J 25:3675–3686. https://doi.org/10.1007/s00586-016-4702-2 + + 10.1007/s00586-016-4702-2 + 27432430 + + + + Itoi E (1991) Roentgenographic analysis of posture in spinal osteoporotics. Spine Phila Pa (1976) 41:750–756. https://doi.org/10.1097/00007632-199107000-00011 + + 10.1097/00007632-199107000-00011 + + + + Yokoyama K, Kawanishi M, Yamada M et al (2017) Age-related variations in global spinal alignment and sagittal balance in asymptomatic Japanese adults. Neurol Res 39:414–418. https://doi.org/10.1080/01616412.2017.1296654 + + 10.1080/01616412.2017.1296654 + 28248611 + + + + Kim J, Hwang JY, Oh JK et al (2017) The association between whole body sagittal balance and risk of falls among elderly patients seeking treatment for back pain. Bone Jt Res 6:337–344. https://doi.org/10.1302/2046-3758.65.BJR-2016-0271.R2 + + 10.1302/2046-3758.65.BJR-2016-0271.R2 + + + + Smorgick Y, Geftler A, Goldstein S et al (2020) Response to: determination of any correlation between sagittal spinopelvic configuration and progressive collapse of acute osteoporotic compression spine fractures: a retrospective radiological analysis. Asian Spine J 14:770–771. https://doi.org/10.31616/asj.2020.0453.r2 + + 10.31616/asj.2020.0453.r2 + 33108844 + 7595807 + + + + Amanda LL, Joanne MM, Mohamed J, Ali G, Brett TA, Laiji Y, Douglas PK, Cupples LA, Mary LB, Thomas G, Travison EJS (2017) Thoracic kyphosis and physical function: the framingham study. J Am Geriatr Soc 65:2257–2264. https://doi.org/10.1111/jgs.15038.Thoracic + + 10.1111/jgs.15038.Thoracic + + + + Ha WS, Shin MH (2019) Postoperative lower limb compensation in patient with adult spinal deformity. J Clin Neurosci 59:106–111. https://doi.org/10.1016/j.jocn.2018.10.119 + + 10.1016/j.jocn.2018.10.119 + 30409531 + + + + +
+ + + 36809334 + + 2023 + 02 + 22 + +
+ + 2050-084X + + 12 + + 2023 + Feb + 21 + + + eLife + Elife + + The role of macrophages in non-small cell lung cancer and advancements in 3D co-cultures. + 10.7554/eLife.82998 + e82998 + + Lung cancer (LC) is the leading cause of cancer-related deaths worldwide. Traditional therapeutic approaches such as chemotherapy or radiotherapy have provided only a marginal improvement in the treatment of lung carcinomas. Inhibitors targeting specific genetic aberrations present in non-small cell lung cancer (NSCLC), the most common subtype (85%), have improved the prognostic outlook, but due to the complexity of the LC mutational spectrum, only a fraction of patients benefit from these targeted molecular therapies. More recently, the realization that the immune infiltrate surrounding solid tumors can foster tumor-promoting inflammation has led to the development and implementation of anticancer immunotherapies in the clinic. In NSCLC, one of the most abundant leukocyte infiltrates is macrophages. These highly plastic phagocytes, which are part of the cellular repertoire of the innate immunity, can have a pivotal role in early NSCLC establishment, malignant progression, and tumor invasion. Emerging macrophage-targeting therapies have been focused on the re-differentiation of the macrophages toward an antitumorigenic phenotype, depletion of tumor-promoting macrophage subtypes, or combination therapies combining traditional cytotoxic treatments with immunotherapeutic agents. The most extensively used models employed for the exploration of NSCLC biology and therapy have been 2D cell lines and murine models. However, studying cancer immunology requires appropriately complex models. 3D platforms, including organoid models, are quickly advancing powerful tools to study immune cell-epithelial cell interactions within the tumor microenvironment. Co-cultures of immune cells along with NSCLC organoids allow for an in vitro observation of the tumor microenvironment dynamics closely resembling in vivo settings. Ultimately, the implementation of 3D organoid technology into tumor microenvironment-modeling platforms might facilitate the exploration of macrophage-targeted therapies in NSCLC immunotherapeutic research, thus establishing a new frontier in NSCLC treatment. + © 2023, Baláž, Balážová et al. + + + + Balážová + Katarína + K + https://orcid.org/0000-0001-9615-6963 + + Hubrecht Institute for Developmental Biology and Stem Cell Research-KNAW & University Medical Centre Utrecht, Utrecht, Netherlands. + + + Oncode Institute, Hubrecht Institute-KNAW, Utrecht, Netherlands. + + + + Clevers + Hans + H + + Roche Pharma Research and early Development, Basel, Switzerland. + + + + Dost + Antonella F M + AFM + https://orcid.org/0000-0001-8705-2409 + + Hubrecht Institute for Developmental Biology and Stem Cell Research-KNAW & University Medical Centre Utrecht, Utrecht, Netherlands. + + + Oncode Institute, Hubrecht Institute-KNAW, Utrecht, Netherlands. + + + + eng + + + Accelerate Lung Regeneration Consortium BREATH 12.0.18.002 + Lung Foundation Netherlands + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Elife + 101579614 + 2050-084X + + IM + + NSCLC + cancer biology + co-culture + lung cancer + macrophages + organoids + + KB, AD No competing interests declared, HC is inventor on patents, owned by the Royal Netherlands Academy of Sciences and related to organoid research. The relevant International Application Numbers are: PCT/NL2008/050543 (Publication Number WO2009/022907) and PCT/NL2010/000017 (Publication Number WO2010/090513). Furthermore, HC is currently employed by Roche (Basel, Switzerland) as head of Pharma Research and Early Development. His full disclosure: www.uu.nl/staff/JCClevers/Additional +
+ + + + 2022 + 11 + 02 + + + 2023 + 02 + 09 + + + 2023 + 2 + 22 + 13 + 42 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809334 + 10.7554/eLife.82998 + 82998 + + +
+ + + 36809339 + + 2023 + 02 + 22 + +
+ + 1553-7404 + + 19 + 2 + + 2023 + Feb + 21 + + + PLoS genetics + PLoS Genet + + Off-target piRNA gene silencing in Drosophila melanogaster rescued by a transposable element insertion. + + e1010598 + + 10.1371/journal.pgen.1010598 + + Transposable elements (TE) are selfish genetic elements that can cause harmful mutations. In Drosophila, it has been estimated that half of all spontaneous visible marker phenotypes are mutations caused by TE insertions. Several factors likely limit the accumulation of exponentially amplifying TEs within genomes. First, synergistic interactions between TEs that amplify their harm with increasing copy number are proposed to limit TE copy number. However, the nature of this synergy is poorly understood. Second, because of the harm posed by TEs, eukaryotes have evolved systems of small RNA-based genome defense to limit transposition. However, as in all immune systems, there is a cost of autoimmunity and small RNA-based systems that silence TEs can inadvertently silence genes flanking TE insertions. In a screen for essential meiotic genes in Drosophila melanogaster, a truncated Doc retrotransposon within a neighboring gene was found to trigger the germline silencing of ald, the Drosophila Mps1 homolog, a gene essential for proper chromosome segregation in meiosis. A subsequent screen for suppressors of this silencing identified a new insertion of a Hobo DNA transposon in the same neighboring gene. Here we describe how the original Doc insertion triggers flanking piRNA biogenesis and local gene silencing. We show that this local gene silencing occurs in cis and is dependent on deadlock, a component of the Rhino-Deadlock-Cutoff (RDC) complex, to trigger dual-strand piRNA biogenesis at TE insertions. We further show how the additional Hobo insertion leads to de-silencing by reducing flanking piRNA biogenesis triggered by the original Doc insertion. These results support a model of TE-mediated gene silencing by piRNA biogenesis in cis that depends on local determinants of transcription. This may explain complex patterns of off-target gene silencing triggered by TEs within populations and in the laboratory. It also provides a mechanism of sign epistasis among TE insertions, illuminates the complex nature of their interactions and supports a model in which off-target gene silencing shapes the evolution of the RDC complex. + Copyright: © 2023 Miller et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Miller + Danny E + DE + https://orcid.org/0000-0001-6096-8601 + + Stowers Institute for Medical Research, Kansas City, Missouri, United States of America. + + + Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, United States of America. + + + Division of Genetic Medicine, Department of Pediatrics, University of Washington and Seattle Children's Hospital, Seattle, Washington, United States of America. + + + Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States of America. + + + + Dorador + Ana P + AP + + Department of Ecology and Evolutionary Biology, University of Kansas, Lawrence, Kansas, United States of America. + + + + Van Vaerenberghe + Kelley + K + + Department of Ecology and Evolutionary Biology, University of Kansas, Lawrence, Kansas, United States of America. + + + Division of Biological Sciences, University of Montana, Missoula, Montana, United States of America. + + + + Li + Angela + A + + Department of Ecology and Evolutionary Biology, University of Kansas, Lawrence, Kansas, United States of America. + + + + Grantham + Emily K + EK + + Department of Ecology and Evolutionary Biology, University of Kansas, Lawrence, Kansas, United States of America. + + + + Cerbin + Stefan + S + https://orcid.org/0000-0002-6873-7688 + + Department of Ecology and Evolutionary Biology, University of Kansas, Lawrence, Kansas, United States of America. + + + + Cummings + Celeste + C + + Department of Ecology and Evolutionary Biology, University of Kansas, Lawrence, Kansas, United States of America. + + + + Barragan + Marilyn + M + + Department of Ecology and Evolutionary Biology, University of Kansas, Lawrence, Kansas, United States of America. + + + + Egidy + Rhonda R + RR + + Stowers Institute for Medical Research, Kansas City, Missouri, United States of America. + + + + Scott + Allison R + AR + + Stowers Institute for Medical Research, Kansas City, Missouri, United States of America. + + + + Hall + Kate E + KE + + Stowers Institute for Medical Research, Kansas City, Missouri, United States of America. + + + + Perera + Anoja + A + https://orcid.org/0000-0003-3965-5293 + + Stowers Institute for Medical Research, Kansas City, Missouri, United States of America. + + + + Gilliland + William D + WD + + Department of Biological Sciences, DePaul University, Chicago, Illinois, United States of America. + + + + Hawley + R Scott + RS + + Stowers Institute for Medical Research, Kansas City, Missouri, United States of America. + + + Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, United States of America. + + + + Blumenstiel + Justin P + JP + https://orcid.org/0000-0001-6221-9292 + + Department of Ecology and Evolutionary Biology, University of Kansas, Lawrence, Kansas, United States of America. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS Genet + 101239074 + 1553-7390 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 07 + 07 + + + 2023 + 01 + 04 + + + 2023 + 2 + 22 + 13 + 42 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809339 + 10.1371/journal.pgen.1010598 + PGENETICS-D-22-00802 + + +
+ + + 36809350 + + 2023 + 02 + 22 + +
+ + 2048-8734 + + + 2023 + Feb + 21 + + + European heart journal. Acute cardiovascular care + Eur Heart J Acute Cardiovasc Care + + Coronary disease in refractory cardiac arrest undergoing resuscitation with extracorporeal membrane oxygenation (E-CPR). + zuad012 + 10.1093/ehjacc/zuad012 + + Because reestablishment of spontaneous circulation (ROSC) in patients with cardiac arrest is frequently not achieved by conventional cardiopulmonary resuscitation (C-CPR), selected patients may undergo resuscitation with extracorporeal membrane oxygenation (E-CPR). We compared angiographic features and percutaneous coronary intervention (PCI) between patients undergoing E-CPR and those with ROSC after C-CPR. + Forty-nine consecutive E-CPR patients undergoing immediate coronary angiography admitted between August 2013 and August 2022 were matched to 49 patients with ROSC after C-CPR. + Multivessel disease (69.4% vs 34.7%; p = 0.001),  ≥ 50% unprotected left main (ULM) stenosis (18.4% vs 4.1%; p = 0.025) and ≥1 chronic total occlusion (CTO) (28.6% vs 10.2%; p = 0.021) were more often documented in E-CPR group. There was no significant differences in the incidence, features and distribution of acute culprit lesion which was present in >90%. SYNTAX (27.6 vs 13.4; p = 0.002) and GENSINI (86.2 vs 46.0; p = 0.001) scores were increased in E-CPR group. Optimal cut-off predicting E-CPR was 19.75 for SYNTAX (sensitivity 74%, specificity 87%) and 60.50 (sensitivity 69%, specificity 75%) for GENSINI score. More lesions were treated (1.3 vs 1.1 lesions/patient; p = 0.002) and stents implanted (2.0 vs 1.3/patient; p < 0.001) in E-CPR group. Final TIMI 3 flow was comparable (88.6% vs 95.7%; p = 0.196) but residual SYNTAX (13.6 vs 3.1; p < 0.001) and GENSINI (36.7 vs 10.9; p < 0.001) scores remained increased in E-CPR group. + E-CPR patients have more multivessel disease, ULM stenosis and CTO but similar incidence, features and distribution of acute culprit lesion. Despite more complex PCI, revascularization is less complete. + © The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. + + + + Franco + Danilo + D + + Center for Intensive Internal Medicine, University Medical Center, Zaloska 7, 1000 Ljubljana, Slovenia. + + + Department of Advance Biomedical Sciences, Federico II University, Via Pansini 5, 80131 Naples, Italy. + + + + Goslar + Tomaz + T + + Center for Intensive Internal Medicine, University Medical Center, Zaloska 7, 1000 Ljubljana, Slovenia. + + + Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia. + + + + Radsel + Peter + P + + Center for Intensive Internal Medicine, University Medical Center, Zaloska 7, 1000 Ljubljana, Slovenia. + + + Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia. + + + + De Luca + Nicola + N + + Department of Advance Biomedical Sciences, Federico II University, Via Pansini 5, 80131 Naples, Italy. + + + + Mancusi + Costantino + C + 0000-0001-6690-1408 + + Department of Advance Biomedical Sciences, Federico II University, Via Pansini 5, 80131 Naples, Italy. + + + + Barbato + Emanuele + E + + Department of Clinical and Molecular Medicine, Sapienza University of Rome, Via di Grottarossa 1035, 00189 Rome, Italy. + + + + Noc + Marko + M + 0000-0003-3303-4306 + + Center for Intensive Internal Medicine, University Medical Center, Zaloska 7, 1000 Ljubljana, Slovenia. + + + Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Eur Heart J Acute Cardiovasc Care + 101591369 + 2048-8726 + + IM + + Refractory cardiac arrest + coronary angiography + percutaneous coronary intervention + +
+ + + + 2023 + 01 + 20 + + + 2023 + 02 + 16 + + + 2023 + 02 + 19 + + + 2023 + 2 + 22 + 13 + 43 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809350 + 7049703 + 10.1093/ehjacc/zuad012 + + +
+ + + 36809340 + + 2023 + 02 + 22 + +
+ + 1558-8238 + + + 2023 + Feb + 21 + + + The Journal of clinical investigation + J Clin Invest + + Local senolysis in aged mice only partially replicates the benefits of systemic senolysis. + 10.1172/JCI162519 + e162519 + + Clearance of senescent cells (SnCs) can prevent several age-related pathologies, including bone loss. However, the local versus systemic roles of SnCs in mediating tissue dysfunction remain unclear. Thus, we developed a mouse model (p16-LOX-ATTAC) that allows for inducible SnC elimination (senolysis) in a cell-specific manner and compared the effects of local versus systemic senolysis during aging using bone as a prototype tissue. Specific removal of Sn osteocytes prevented age-related bone loss at the spine, but not the femur, by improving bone formation without affecting osteoclasts or marrow adipocytes. By contrast, systemic senolysis prevented bone loss at the spine and femur and not only improved bone formation, but also reduced osteoclasts and marrow adipocytes. Transplantation of SnCs into the peritoneal cavity of young mice caused bone loss and also induced senescence in distant host osteocytes. Collectively, our findings provide the first proof-of-concept evidence that local senolysis has health benefits in the context of aging, but importantly, local senolysis only partially replicates the benefits of systemic senolysis. Further, we establish that SnCs, through their SASP, lead to senescence in distant cells. Therefore, our study indicates that optimizing senolytic drugs may require systemic instead of local SnC targeting to extend healthy aging. + + + + Farr + Joshua N + JN + + Endocrinology, Mayo Clinic, Rochester, United States of America. + + + + Saul + Dominik + D + + Kogod Center on Aging, Mayo Clinic, Rochester, United States of America. + + + + Doolittle + Madison L + ML + + Kogod Center on Aging, Mayo Clinic, Rochester, United States of America. + + + + Kaur + Japneet + J + + Kogod Center on Aging, Mayo Clinic, Rochester, United States of America. + + + + Rowsey + Jennifer L + JL + + Endocrinology, Mayo Clinic, Rochester, United States of America. + + + + Vos + Stephanie J + SJ + + Kogod Center on Aging, Mayo Clinic, Rochester, United States of America. + + + + Froemming + Mitchell N + MN + + Kogod Center on Aging, Mayo Clinic, Rochester, United States of America. + + + + Lagnado + Anthony B + AB + + Physiology, Mayo Clinic, Rochester, United States of America. + + + + Zhu + Yi + Y + + Mayo Clinic, Rochester, United States of America. + + + + Weivoda + Megan M + MM + + Department of Medicine, Mayo Clinic, Rochester, United States of America. + + + + Ikeno + Yuji + Y + + Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, United States of America. + + + + Pignolo + Robert J + RJ + + Mayo Clinic, Rochester, United States of America. + + + + Niedernhofer + Laura J + LJ + + Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, United States of America. + + + + Robbins + Paul D + PD + + Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, United States of America. + + + + Jurk + Diana + D + + Mayo Clinic, Rochester, United States of America. + + + + Passos + João F + JF + + Kogod Center on Aging, Mayo Clinic, Rochester, United States of America. + + + + LeBrasseur + Nathan K + NK + + Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, United States of America. + + + + Tchkonia + Tamara + T + + Mayo Clinic, Rochester, United States of America. + + + + Kirkland + James L + JL + + Mayo Clinic, Rochester, United States of America. + + + + Monroe + David G + DG + + Kogod Center on Aging, Mayo Clinic, Rochester, United States of America. + + + + Khosla + Sundeep + S + + Mayo Clinic, Rochester, United States of America. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + J Clin Invest + 7802877 + 0021-9738 + + IM + + Aging + Bone Biology + Bone disease + Cellular senescence + Osteoporosis + +
+ + + + 2023 + 2 + 22 + 13 + 42 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809340 + 162519 + 10.1172/JCI162519 + + +
+ + + 36809349 + + 2023 + 02 + 22 + +
+ + 1527-6473 + + + 2023 + Jan + 03 + + + Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society + Liver Transpl + + Timing is everything: sleeve gastrectomy and liver transplantation. + 10.1097/LVT.0000000000000005 + + + Ryan + Randi J + RJ + + Mayo Clinic, Transplantation Surgery, Rochester, MN. + + + + Heimbach + Julie K + JK + + + Diwan + Tayyab D + TD + + + eng + + Journal Article + + + 2023 + 01 + 03 + +
+ + United States + Liver Transpl + 100909185 + 1527-6465 + + IM +
+ + + + 2022 + 10 + 10 + + + 2022 + 10 + 10 + + + 2023 + 2 + 22 + 13 + 43 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809349 + 10.1097/LVT.0000000000000005 + 01445473-990000000-00004 + + + + Wong RJ, Singal AK. Trends in liver disease etiology among adults awaiting liver transplantation in the United States, 2014-2019. JAMA Netw Open. 2020;3:e1920294. + + + Perez-Protto SE, Quintini C, Reynolds LF, You J, Cywinski JB, Sessler DI, et al. Comparable graft and patient survival in lean and obese liver transplant recipients. Liver Transpl. 2013;19:907–15. + + + Leonard J, Heimbach JK, Malinchoc M, Watt K, Charlton M. The impact of obesity on long-term outcomes in liver transplant recipients-results of the NIDDK liver transplant database. Am J Transplant. 2008;8:667–72. + + + Spengler EK, O’Leary JG, Te HS, Rogal S, Pillai AA, Al-Osaimi A, et al. Liver transplantation in the obese cirrhotic patient. Transplantation. 2017;101:2288–2296. + + + Conzen KD, Vachharajani N, Collins KM, Anderson CD, Lin Y, Wellen JR, et al. Morbid obesity in liver transplant recipients adversely affects longterm graft and patient survival in a single-institution analysis. HPB (Oxford). 2015;17:251–7. + + + Dare AJ, Plank LD, Phillips AR, Gane EJ, Harrison B, Orr D, et al. Additive effect of pretransplant obesity, diabetes, and cardiovascular risk factors on outcomes after liver transplantation. Liver Transpl. 2014;20:281–90. + + + Borges-Canha M, Neves JS, Mendonca F, Silva MM, Costa C, Cabral PM, et al. The impact of bariatric surgery on hepatic function and predictors of liver steatosis and fibrosis. Obes Surg. 2020;30:2935–2941. + + + Heimbach JK, Watt KD, Poterucha JJ, Ziller NF, Cecco SD, Charlton MR, et al. Combined liver transplantation and gastric sleeve resection for patients with medically complicated obesity and end-stage liver disease. Am J Transplant. 2013;13:363–8. + + + Morris MC, Jung AD, Kim Y, Lee TC, Kaiser TE, Thompson JR, et al. Delayed sleeve gastrectomy following liver transplantation: a 5-year experience. Liver Transpl. 2019;25:1673–1681. + + + Tariq N, Saharia A, Nwokedi U, Hobeika MJ, Mobley CM, Hsu D, et al. Combined liver transplant and sleeve gastrectomy: report of a brief-interval staged approach. Liver Transpl. 2022. + + + +
+ + + 36809345 + + 2023 + 02 + 22 + +
+ + 2471-254X + + 7 + 3 + + 2023 + Mar + 01 + + + Hepatology communications + Hepatol Commun + + Copper deficiency is an independent risk factor for mortality in patients with advanced liver disease. + + e0076 + + 10.1097/HC9.0000000000000076 + + Copper is an essential trace metal serving as a cofactor in innate immunity, metabolism, and iron transport. We hypothesize that copper deficiency may influence survival in patients with cirrhosis through these pathways. + We performed a retrospective cohort study involving 183 consecutive patients with cirrhosis or portal hypertension. Copper from blood and liver tissues was measured using inductively coupled plasma mass spectrometry. Polar metabolites were measured using nuclear magnetic resonance spectroscopy. Copper deficiency was defined by serum or plasma copper below 80 µg/dL for women or 70 µg/dL for men. + The prevalence of copper deficiency was 17% (N=31). Copper deficiency was associated with younger age, race, zinc and selenium deficiency, and higher infection rates (42% vs. 20%, p=0.01). Serum copper correlated positively with albumin, ceruloplasmin, hepatic copper, and negatively with IL-1β. Levels of polar metabolites involved in amino acids catabolism, mitochondrial transport of fatty acids, and gut microbial metabolism differed significantly according to copper deficiency status. During a median follow-up of 396 days, mortality was 22.6% in patients with copper deficiency compared with 10.5% in patients without. Liver transplantation rates were similar (32% vs. 30%). Cause-specific competing risk analysis showed that copper deficiency was associated with a significantly higher risk of death before transplantation after adjusting for age, sex, MELD-Na, and Karnofsky score (HR: 3.40, 95% CI, 1.18-9.82, p=0.023). + In advanced cirrhosis, copper deficiency is relatively common and is associated with an increased infection risk, a distinctive metabolic profile, and an increased risk of death before transplantation. + Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Association for the Study of Liver Diseases. + + + + Yu + Lei + L + 0000-0002-4622-657 + + Department of Medicine, Division of Gastroenterology and Center for Liver Investigation Fostering Discovery, University of Washington, Seattle, Washington, USA. + + + + Yousuf + Sarim + S + + College of Medicine, Ziauddin University, Karachi, Pakistan. + + + + Yousuf + Shahrukh + S + + Department of Medicine, Division of Gastroenterology and Center for Liver Investigation Fostering Discovery, University of Washington, Seattle, Washington, USA. + + + + Yeh + Jeffrey + J + + Department of Medicine, Division of Gastroenterology and Center for Liver Investigation Fostering Discovery, University of Washington, Seattle, Washington, USA. + + + + Biggins + Scott W + SW + + Department of Medicine, Division of Gastroenterology and Center for Liver Investigation Fostering Discovery, University of Washington, Seattle, Washington, USA. + + + + Morishima + Chihiro + C + 0000-0001-5330-9464 + + Department of Lab Medicine and Pathology, University of Washington, Seattle, Washington, USA. + + + + Shyu + Irene + I + + Department of Lab Medicine and Pathology, University of Washington, Seattle, Washington, USA. + + + + O'Shea-Stone + Galen + G + + Department of Chemistry, Montana State University, Bozeman, Montana, USA. + + + + Eilers + Brian + B + + Department of Chemistry, Montana State University, Bozeman, Montana, USA. + + + + Waldum + Annie + A + + Department of Chemistry, Montana State University, Bozeman, Montana, USA. + + + + Copié + Valérie + V + 0000-0002-2778-1463 + + Department of Chemistry, Montana State University, Bozeman, Montana, USA. + + + + Burkhead + Jason + J + 0000-0001-5457-311 + + Department of Biological Sciences, University of Alaska Anchorage, Anchorage, Alaska, USA. + + + + eng + + Journal Article + + + 2023 + 02 + 20 + +
+ + United States + Hepatol Commun + 101695860 + 2471-254X + + IM +
+ + + + 2022 + 07 + 19 + + + 2022 + 11 + 17 + + + 2023 + 2 + 22 + 13 + 43 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809345 + 10.1097/HC9.0000000000000076 + 02009842-202303010-00019 + + + + Asrani SK, Kouznetsova M, Ogola G, Taylor T, Masica A, Pope B, et al. Increasing health care burden of chronic liver disease compared with other chronic diseases, 2004-13. Gastroenterology. 2018;155:719–729.e4. + + + European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu, European Association for the Study of the Liver. EASL Clinical Practice Guidelines on nutrition in chronic liver disease. J Hepatol. 2019;70:172–93. + + + Lai JC, Tandon P, Bernal W, Tapper EB, Ekong U, Dasarathy S, et al. Malnutrition, frailty, and sarcopenia in patients with cirrhosis: 2021 Practice Guidance by the American Association for the Study of Liver Diseases. Hepatology. 2021;74:1611–44. + + + Uauy R, Olivares M, Gonzalez M. 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Free Radic Biol Med. 1996;20:483–8. + + + Owen CA. Distribution of copper in the rat. Am J Physiol. 1964;207:446–8. + + + Moctezuma-Velazquez C, Ebadi M, Bhanji RA, Stirnimann G, Tandon P, Montano-Loza AJ. Limited performance of subjective global assessment compared to computed tomography-determined sarcopenia in predicting adverse clinical outcomes in patients with cirrhosis. Clin Nutr. 2019;38:2696–703. + + + Figueiredo FAF, Perez RM, Freitas MM, Kondo M. Comparison of three methods of nutritional assessment in liver cirrhosis: subjective global assessment, traditional nutritional parameters, and body composition analysis. J Gastroenterol. 2006;41:476–82. + + + Schosinsky KH, Lehmann HP, Beeler MF. Measurement of ceruloplasmin from its oxidase activity in serum by use of o-dianisidine dihydrochloride. Clin Chem. 1974;20:1556–63. + + + +
+ + + 36809348 + + 2023 + 02 + 22 + +
+ + 1613-9860 + + + 2023 + Feb + 21 + + + Translational behavioral medicine + Transl Behav Med + + Cost and cost-effectiveness analysis of a digital diabetes prevention program: results from the PREDICTS trial. + ibad008 + 10.1093/tbm/ibad008 + + Although technology-assisted diabetes prevention programs (DPPs) have been shown to improve glycemic control and weight loss, information are limited regarding relevant costs and their cost-effectiveness. To describe a retrospective within-trial cost and cost-effectiveness analysis (CEA) to compare a digital-based DPP (d-DPP) with small group education (SGE), over a 1-year study period. The costs were summarized into direct medical costs, direct nonmedical costs (i.e., times that participants spent engaging with the interventions), and indirect costs (i.e., lost work productivity costs). The CEA was measured by the incremental cost-effectiveness ratio (ICER). Sensitivity analysis was performed using nonparametric bootstrap analysis. Over 1 year, the direct medical costs, direct nonmedical costs, and indirect costs per participant were $4,556, $1,595, and $6,942 in the d-DPP group versus $4,177, $1,350, and $9,204 in the SGE group. The CEA results showed cost savings from d-DPP relative to SGE based on a societal perspective. Using a private payer perspective for d-DPP, ICERs were $4,739 and $114 to obtain an additional unit reduction in HbA1c (%) and weight (kg), and were $19,955 for an additional unit gain of quality-adjusted life years (QALYs) compared to SGE, respectively. From a societal perspective, bootstrapping results indicated that d-DPP has a 39% and a 69% probability, at a willingness-to-pay of $50,000/QALY and $100,000/QALY, respectively, of being cost-effective. The d-DPP was cost-effective and offers the prospect of high scalability and sustainability due to its program features and delivery modes, which can be easily translated to other settings. + © Society of Behavioral Medicine 2023. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. + + + + Michaud + Tzeyu L + TL + 0000-0002-2053-3942 + + Department of Health Promotion, College of Public Health, University of Nebraska Medical Center, Omaha, NE, USA. + + + Center for Reducing Health Disparities, College of Public Health, University of Nebraska Medical Center, Omaha, NE, USA. + + + + Wilson + Kathryn E + KE + 0000-0001-5847-5461 + + Department of Kinesiology and Health, College of Education & Human Development, Georgia State University, Atlanta, GA, USA. + + + Center for the Study of Stress, Trauma, and Resilience, College of Education and Human Development, Georgia State University, Atlanta, GA, USA. + + + + Katula + Jeffrey A + JA + + Department of Health and Exercise Science, Wake Forest University, Winston-Salem, NC, USA. + + + + You + Wen + W + + Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA. + + + + Estabrooks + Paul A + PA + + Department of Health and Kinesiology, College of Health, University of Utah, Salt Lake City, UT, USA. + + + + eng + + + Omada Health + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Transl Behav Med + 101554668 + 1613-9860 + + IM + + Although technology-assisted DPPs have been shown to improve glycemic control and/or weight loss, information is limited on examining relevant costs and the cost-effectiveness of DPPs with the use of remote technologies within a randomized controlled trial design. We evaluated the costs associated with a d-DPP and further examined the cost-effectiveness of the d-DPP with an enhanced usual care condition. The d-DPP was cost-effective in achieving HbA1c reduction and weight loss and offers the prospect of high scalability and sustainability due to its program features and delivery modes, which can be easily translated to other settings. + + + absenteeism + digital health + economic evaluation + lifestyle intervention + presenteeism + work productivity + +
+ + + + 2023 + 2 + 22 + 13 + 43 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809348 + 7049675 + 10.1093/tbm/ibad008 + + +
+ + + 36809346 + + 2023 + 02 + 22 + +
+ + 2471-254X + + 7 + 3 + + 2023 + Mar + 01 + + + Hepatology communications + Hepatol Commun + + Dexamethasone mitigates remdesivir-induced liver toxicity in human primary hepatocytes and COVID-19 patients. + + e0034 + + 10.1097/HC9.0000000000000034 + + Coronavirus disease 2019 (COVID-19) is a global pandemic that has caused more than 600 million cases and over six million deaths worldwide. Despite the availability of vaccination, COVID-19 cases continue to grow making pharmacological interventions essential. Remdesivir (RDV) is an FDA-approved antiviral drug for treatment of both hospitalized and non-hospitalized COVID-19 patients, albeit with potential for hepatotoxicity. This study characterizes the hepatotoxicity of RDV and its interaction with dexamethasone (DEX), a corticosteroid often co-administered with RDV for inpatient treatment of COVID-19. + Human primary hepatocytes and HepG2 cells were used as in vitro models for toxicity and drug-drug interaction studies. Real-world data from hospitalized COVID-19 patients were analyzed for drug-induced elevation of serum ALT and AST. + In cultured hepatocytes, RDV markedly reduced the hepatocyte viability and albumin synthesis, while it increased the cleavage of caspase-8 and caspase-3, phosphorylation of histone H2AX, and release of ALT and AST in a concentration-dependent manner. Importantly, co-treatment with DEX partially reversed RDV-induced cytotoxic responses in human hepatocytes. Moreover, data from COVID-19 patients treated with RDV with and without DEX co-treatment suggested that among 1037 patients matched by propensity score, receiving the drug combination was less likely to result in elevation of serum AST and ALT levels (≥ 3 × ULN) compared to the RDV alone treated patients (OR = 0.44, 95% CI = 0.22-0.92, p = 0.03). + Our findings obtained from in vitro cell-based experiments and patient data analysis provide evidence suggesting combination of DEX and RDV holds the potential to reduce the likelihood of RDV-induced liver injury in hospitalized COVID-19 patients. + Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Association for the Study of Liver Diseases. + + + + Liu + Kaiyan + K + 0000-0001-9416-8565 + + Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland, USA. + + + + Stern + Sydney + S + 0000-0002-1479-605 + + Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland, USA. + + + + Heil + Emily L + EL + 0000-0002-6644-6684 + + Department of Pharmacy Practice and Science, University of Maryland School of Pharmacy, Baltimore, Maryland, USA. + + + + Li + Linhao + L + 0000-0003-3204-0915 + + Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland, USA. + + + + Khairi + Rula + R + 0000-0003-0054-6786 + + Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland, USA. + + + + Heyward + Scott + S + 0000-0001-7805-3522 + + BioIVT, 1450 S Rolling Rd, Halethorpe, Maryland, USA. + + + + Wang + Hongbing + H + 0000-0002-6224-6888 + + Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland, USA. + + + + eng + + Journal Article + + + 2023 + 02 + 20 + +
+ + United States + Hepatol Commun + 101695860 + 2471-254X + + IM +
+ + + + 2023 + 2 + 22 + 13 + 43 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809346 + 10.1097/HC9.0000000000000034 + 02009842-202303010-00018 + + + + Mishra SK, Tripathi T. One year update on the COVID-19 pandemic: Where are we now? Acta Trop. 2021;214:105778. + + + Verity R, Okell LC, Dorigatti I, Winskill P, Whittaker C, Imai N, et al. Estimates of the severity of coronavirus disease 2019: a model-based analysis. Lancet Infect Dis. 2020;20:669–677. + + + Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395:1054–1062. + + + Porter DP, Weidner JM, Gomba L, Bannister R, Blair C, Jordan R, et al. Remdesivir (GS-5734) is efficacious in cynomolgus macaques infected with marburg virus. J Infect Dis. 2020;222:1894–1901. + + + Warren TK, Jordan R, Lo MK, Ray AS, Mackman RL, Soloveva V, et al. Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys. Nature. 2016;531:381–385. + + + de Wit E, Feldmann F, Cronin J, Jordan R, Okumura A, Thomas T, et al. Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection. Proc Natl Acad Sci U S A. 2020;117:6771–6776. + + + Wang M, Cao R, Zhang L, Yang X, Liu J, Xu M, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020;30:269–271. + + + Gordon CJ, Tchesnokov EP, Woolner E, Perry JK, Feng JY, Porter DP, et al. Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency. J Biol Chem. 2020;295:6785–6797. + + + Runfeng L, Yunlong H, Jicheng H, Weiqi P, Qinhai M, Yongxia S, et al. Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2). Pharmacol Res. 2020;156:104761. + + + Beigel JH, Tomashek KM, Dodd LE, Mehta AK, Zingman BS, Kalil AC, et al. Remdesivir for the Treatment of Covid-19 - Final Report. N Engl J Med. 2020;383:1813–1826. + + + Mozaffari E, Chandak A, Zhang Z, Liang S, Thrun M, Gottlieb RL, et al. Remdesivir treatment in hospitalized patients with COVID-19: a comparative analysis of in-hospital all-cause mortality in a large multi-center observational cohort. Clin Infect Dis. 2021;75:e450–e458. + + + Gottlieb RL, Vaca CE, Paredes R, Mera J, Webb BJ, Perez G, et al. Early Remdesivir to Prevent Progression to Severe COVID-19 in Outpatients. N Engl J Med. 2021;386(4):305–315. + + + Consortium WHOST. Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses. Lancet. 2022;399:1941–1953. + + + Zampino R, Mele F, Florio LL, Bertolino L, Andini R, Galdo M, et al. Liver injury in remdesivir-treated COVID-19 patients. Hepatol Int. 2020;14:881–883. + + + Aleem A, Mahadevaiah G, Shariff N, Kothadia JP. Hepatic manifestations of COVID-19 and effect of remdesivir on liver function in patients with COVID-19 illness. Proc (Bayl Univ Med Cent). 2021;34:473–477. + + + Xu Y, Barauskas O, Kim C, Babusis D, Murakami E, Kornyeyev D, et al. Off-target in vitro profiling demonstrates that remdesivir is a highly selective antiviral agent. Antimicrob Agents Chemother. 2021;65:e02237–20. + + + Carothers C, Birrer K, Vo M. Acetylcysteine for the treatment of suspected remdesivir-associated acute liver failure in COVID-19: A Case Series. Pharmacotherapy. 2020;40:1166–1171. + + + Group RC, Horby P, Lim WS, Emberson JR, Mafham M, Bell JL, et al. Dexamethasone in hospitalized patients with COVID-19. N Engl J Med. 2021;384:693–704. + + + Tomazini BM, Maia IS, Cavalcanti AB, Berwanger O, Rosa RG, Veiga VC, et al. Effect of dexamethasone on days alive and ventilator-free in patients with moderate or severe acute respiratory distress syndrome and COVID-19: The CoDEX randomized clinical trial. JAMA. 2020;324:1307–1316. + + + Benfield T, Bodilsen J, Brieghel C, Harboe ZB, Helleberg M, Holm C, et al. Improved survival among hospitalized patients with COVID-19 treated with remdesivir and dexamethasone. A nationwide population-based cohort study. Clin Infect Dis. 2021;73:2031–2036. + + + NIH. Coronavirus Disease 2019 (COVID-19) Treatment Guidelines. In; 2022. + + + Chou JY, Wan YJ, Sakiyama T. Regulation of rat liver maturation in vitro by glucocorticoids. Mol Cell Biol. 1988;8:203–209. + + + Li L, Welch MA, Li Z, Mackowiak B, Heyward S, Swaan PW, et al. Mechanistic insights of phenobarbital-mediated activation of human but not mouse pregnane X receptor. Mol Pharmacol. 2019;96:345–354. + + + Humeniuk R, Mathias A, Cao H, Osinusi A, Shen G, Chng E, et al. Safety, tolerability, and pharmacokinetics of remdesivir, an antiviral for treatment of COVID-19, in healthy subjects. Clin Transl Sci. 2020;13:896–906. + + + FDA. VEKLURY (remdesivir) package insert. In; 2022. + + + FDA. CDER. Guidance for Industry Drug-Induced Liver Injury: Premarketing Clinical Evaluation. FDA document, CDER, Silver Spring, MD. FDA document, CDER, Silver Spring, MD. 2009. + + + Valdiglesias V, Giunta S, Fenech M, Neri M, Bonassi S. gammaH2AX as a marker of DNA double strand breaks and genomic instability in human population studies. Mutat Res. 2013;753:24–40. + + + Abu-Qare AW, Abou-Donia MB. Biomarkers of apoptosis: release of cytochrome c, activation of caspase-3, induction of 8-hydroxy-2'-deoxyguanosine, increased 3-nitrotyrosine, and alteration of p53 gene. J Toxicol Environ Health B Crit Rev. 2001;4:313–332. + + + Tummers B, Green DR. Caspase-8: regulating life and death. Immunol Rev. 2017;277:76–89. + + + Johnson CR, Jarvis WD. Caspase-9 regulation: an update. Apoptosis. 2004;9:423–427. + + + Mah LJ, El-Osta A, Karagiannis TC. gammaH2AX: a sensitive molecular marker of DNA damage and repair. Leukemia. 2010;24:679–686. + + + Wen W, Chen C, Tang J, Wang C, Zhou M, Cheng Y, et al. Efficacy and safety of three new oral antiviral treatment (molnupiravir, fluvoxamine and Paxlovid) for COVID-19a meta-analysis. Ann Med. 2022;54:516–523. + + + Sidhu JS, Liu F, Omiecinski CJ. Phenobarbital responsiveness as a uniquely sensitive indicator of hepatocyte differentiation status: requirement of dexamethasone and extracellular matrix in establishing the functional integrity of cultured primary rat hepatocytes. Exp Cell Res. 2004;292:252–264. + + + FDA. HEMADY (dexamethasone tablets) package insert. In; 2019. + + + Abouir K, Gosselin P, Guerrier S, Daali Y, Desmeules J, Grosgurin O, et al. Dexamethasone exposure in normal-weight and obese hospitalized COVID-19 patients: An observational exploratory trial. Clin Transl Sci. 2022;15:1796–1804. + + + McGill MR. The past and present of serum aminotransferases and the future of liver injury biomarkers. EXCLI J. 2016;15:817–828. + + + Spinella R, Sawhney R, Jalan R. Albumin in chronic liver disease: structure, functions and therapeutic implications. Hepatol Int. 2016;10:124–132. + + + Khalatbari A, Aghazadeh Z, Ji C. Adverse effects of Anti-Covid-19 drug candidates and alcohol on cellular stress responses of hepatocytes. Hepatol Commun. 2021;6:1262–1277. + + + Oh HY, Namkoong S, Lee SJ, Por E, Kim CK, Billiar TR, et al. Dexamethasone protects primary cultured hepatocytes from death receptor-mediated apoptosis by upregulation of cFLIP. Cell Death Differ. 2006;13:512–523. + + + Bailly-Maitre B, de Sousa G, Boulukos K, Gugenheim J, Rahmani R. Dexamethasone inhibits spontaneous apoptosis in primary cultures of human and rat hepatocytes via Bcl-2 and Bcl-xL induction. Cell Death Differ. 2001;8:279–288. + + + Li R, Liclican A, Xu Y, Pitts J, Niu C, Zhang J, et al. Key metabolic enzymes involved in remdesivir activation in human lung cells. Antimicrob Agents Chemother. 2021;65:e0060221. + + + Shen Y, Eades W, Yan B. The COVID-19 medicine remdesivir is therapeutically activated by carboxylesterase-1, and excessive hydrolysis increases cytotoxicity. Hepatol Commun. 2021;5:1622–1623. + + + Zhu W, Song L, Zhang H, Matoney L, LeCluyse E, Yan B. Dexamethasone differentially regulates expression of carboxylesterase genes in humans and rats. Drug Metab Dispos. 2000;28:186–191. + + + Senior JR. Alanine aminotransferase: a clinical and regulatory tool for detecting liver injury-past, present, and future. Clin Pharmacol Ther. 2012;92:332–339. + + + Kunutsor SK, Laukkanen JA. Hepatic manifestations and complications of COVID-19: A systematic review and meta-analysis. J Infect. 2020;81:e72–e74. + + + +
+ + + 36809351 + + 2023 + 02 + 22 + +
+ + 1861-0692 + + + 2023 + Feb + 21 + + + Clinical research in cardiology : official journal of the German Cardiac Society + Clin Res Cardiol + + Thrombotic ST-segment elevation myocardial infarction caused by a caseous mitral annular calcification. + 10.1007/s00392-023-02167-7 + + + Al-Kassou + Baravan + B + http://orcid.org/0000-0003-2967-6613 + + Heart Center Bonn, Department of Medicine II, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany. + + + + Weber + Marcel + M + + Heart Center Bonn, Department of Medicine II, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany. + + + + Nickenig + Georg + G + + Heart Center Bonn, Department of Medicine II, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany. + + + + Zimmer + Sebastian + S + + Heart Center Bonn, Department of Medicine II, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany. sebastian.zimmer@ukbonn.de. + + + + eng + + Letter + + + 2023 + 02 + 21 + +
+ + Germany + Clin Res Cardiol + 101264123 + 1861-0684 + + IM +
+ + + + 2023 + 01 + 06 + + + 2023 + 02 + 02 + + + 2023 + 2 + 22 + 13 + 43 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809351 + 10.1007/s00392-023-02167-7 + 10.1007/s00392-023-02167-7 + + + + Churchill TW, Yucel E, Deferm S, Levine RA, Hung J, Bertrand PB (2022) Mitral valve dysfunction in patients with annular calcification: JACC review topic of the week. J Am Coll Cardiol 80:739–751 + + 10.1016/j.jacc.2022.05.032 + 35953139 + + + + Chehab O, Roberts-Thomson R, Bivona A et al (2022) Management of patients with severe mitral annular calcification: JACC state-of-the-art review. J Am Coll Cardiol 80:722–738 + + 10.1016/j.jacc.2022.06.009 + 35953138 + + + + Curl E, Riemer E (2018) Caseous calcification of the mitral annulus: case report and brief review. Eur Heart J Case Rep 2:124 + + + Harpaz D, Auerbach I, Vered Z, Motro M, Tobar A, Rosenblatt S (2001) Caseous calcification of the mitral annulus: a neglected, unrecognized diagnosis. J Am Soc Echocardiogr 14:825–831 + + 10.1067/mje.2001.111877 + 11490332 + + + + Elgendy IY, Conti CR (2013) Caseous calcification of the mitral annulus: a review. Clin Cardiol 36:E27-31 + + 24038099 + 6649616 + + + + Mayr A, Muller S, Feuchtner G (2021) The spectrum of caseous mitral annulus calcifications. JACC Case Rep 3:104–108 + + 10.1016/j.jaccas.2020.09.039 + 34317479 + + + + Movahed MR, Saito Y, Ahmadi-Kashani M, Ebrahimi R (2007) Mitral annulus calcification is associated with valvular and cardiac structural abnormalities. Cardiovasc Ultrasound 5:14 + + 10.1186/1476-7120-5-14 + 17359540 + 1838405 + + + + Dietl CA, Hawthorn CM, Raizada V (2016) Risk of cerebral embolization with caseous calcification of the mitral annulus: review article. Open Cardiovasc Med J 10:221–232 + + 10.2174/1874192401610010221 + 27990181 + 5120388 + + + + Matsuyama TA, Ishibashi-Ueda H, Ikeda Y et al (2012) Critical multi-organ emboli originating from collapsed, vulnerable caseous mitral annular calcification. Pathol Int 62:496–499 + + 10.1111/j.1440-1827.2012.02826.x + 22726070 + + + + +
+ + + 36809335 + + 2023 + 02 + 22 + +
+ + 2164-2591 + + 12 + 2 + + 2023 + Feb + 01 + + + Translational vision science & technology + Transl Vis Sci Technol + + Transcorneal Electrical Stimulation Dose-Dependently Slows the Visual Field Loss in Retinitis Pigmentosa. + + 29 + + 10.1167/tvst.12.2.29 + + To assess whether transcorneal electrical stimulation (TcES) current-dependently slows progressive loss of visual field area (VFA) in retinitis pigmentosa (RP). + Data from 51 patients with RP who received monocular TcES treatment once weekly over 1 year in an interventional, randomized study have been analyzed a posteriori. Current amplitudes were 0.1 to 1.0 mA in the TcES-treated group (n = 31) and 0.0 mA in the sham group (n = 20). VFA was assessed in both eyes (semiautomatic kinetic perimetry, Goldmann targets V4e, III4e). Annual decline rate (ADR) of exponential loss and model-independent percentage reduction of VFA at treatment cessation were correlated to current amplitude. + For V4e, mean ADR was -4.1% in TcES-treated eyes, -6.4% in untreated fellow eyes, and -7.2% in placebo-treated eyes; mean VFA reduction in TcES-treated eyes was 64% less than in untreated fellow eyes (P = 0.013) and 72% less than in placebo-treated eyes (P = 0.103). Individual VFA reductions correlated with current amplitude (P = 0.043) and tended toward zero in patients who received 0.8 to 1.0 mA. For III4e, there was a marginally significant current-dependency of interocular difference in reduction (P = 0.11). ADR and VFA reduction did not significantly correlate with baseline VFA. + Loss of VFA (V4e) in patients with RP was significantly reduced in treated eyes compared to untreated eyes by regular use of TcES in a dose-dependent manner. No dependence of effects on the initial extent of VFA loss was found. + TcES provides potential for preservation of visual field in patients with RP. + + + + Stett + Alfred + A + + Okuvision GmbH, Reutlingen, Germany. + + + + Schatz + Andreas + A + + Centre for Ophthalmology, University Eye Hospital, Eberhard-Karls University Tübingen, Tübingen, Germany. + + + + Gekeler + Florian + F + + Centre for Ophthalmology, University Eye Hospital, Eberhard-Karls University Tübingen, Tübingen, Germany. + + + Department of Ophthalmology, Klinikum Stuttgart, Stuttgart, Germany. + + + + Franklin + Jeremy + J + + Institute of Medical Statistics and Computational Biology, University of Cologne, Cologne, Germany. + + + + eng + + Journal Article + +
+ + United States + Transl Vis Sci Technol + 101595919 + 2164-2591 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 42 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809335 + 2785389 + 10.1167/tvst.12.2.29 + + +
+ + + 36809352 + + 2023 + 02 + 22 + +
+ + 1559-713X + + + 2023 + Feb + 21 + + + Simulation in healthcare : journal of the Society for Simulation in Healthcare + Simul Healthc + + Applicability of Artificial Societies to Evaluate Health Care Policies. + 10.1097/SIH.0000000000000718 + + We propose the use of artificial societies to support health care policymakers in understanding and forecasting the impact and adverse effects of policies. Artificial societies extend the agent-based modeling paradigm using social science research to allow integrating the human component. We simulate individuals as socially capable software agents with their individual parameters in their situated environment including social networks. We describe the application of our method to better understand policy effects on the opioid crisis in Washington, DC, as an example. We document how to initialize the agent population with a mix of empiric and synthetic data, calibrate the model, and make forecasts of possible developments. The simulation forecasts a rise in opioid-related deaths as they were observed during the pandemic. This article demonstrates how to take human aspects into account when evaluating health care policies. + Copyright © 2023 Society for Simulation in Healthcare. + + + + Tolk + Andreas + A + + From the The MITRE Corporation (A.T., B.S.P., J.C.C., S.A.R.), Charlottesville, VA; Georgetown University (W.B.R.), Washington, DC; Virginia Modeling Analysis and Simulation Center (S.Y.D.), Old Dominion University, Norfolk, VA. + + + + Rouse + William B + WB + + + Pires + Bianica S + BS + + + Cline + Jon C + JC + + + Diallo + Saikou Y + SY + + + Russell + Sybil A + SA + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Simul Healthc + 101264408 + 1559-2332 + + IM + The authors declare no conflict of interest. +
+ + + + 2023 + 2 + 22 + 13 + 43 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809352 + 10.1097/SIH.0000000000000718 + 01266021-990000000-00055 + + + + Pool R. The third branch of science debuts: computer simulation has opened a new eye on the world, giving scientists in fields from biology to high-energy physics a way to perform experiments that would be otherwise impossible. Science 1992;256(5053):44–47. + + + Nealon J, Moreno A. Agent-based applications in health care. In: Moreno A, Nealon J, eds. Applications of Software Agent Technology in the Health Care Domain. Basel, Switzerland: Birkhäuser; 2003:3–18. + + + Gaba DM. The future vision of simulation in healthcare. Simul Healthc 2007;2(2):126–135. + + + Rohleder TR, Lewkonia P, Bischak DP, Duffy P, Hendijani R. Using simulation modeling to improve patient flow at an outpatient orthopedic clinic. Health Care Manag Sci 2011;14(2):135–145. + + + Gilbert N, Ahrweiler P, Barbrook-Johnson P, Narasimhan KP, Wilkinson H. Computational modelling of public policy: reflections on practice. J Artif Soc Soc Simul 2018;21(1):3669. + + + Rouse WB. Understanding the complexity of health. Systems Research and Behavioral Science 2021;38(2):197–203. + + + Braveman P, Gottlieb L. The social determinants of health: it's time to consider the causes of the causes. Public Health Rep 2014;129(suppl 2):19–31. + + + Squazzoni F, Polhill JG, Edmonds B, et al. Computational models that matter during a global pandemic outbreak: a call to action. J Artif Soc Soc Simul 2020;23(2):4298. + + + Shults FL, Wildman WJ, Diallo S, Puga-Gonzalez I, Voas D. The artificial society analytics platform. In: Verhagen H, Borit M, Bravo G, et al, eds. Advances in Social Simulation. Cham, Switzerland: Springer; 2020:411–426. + + + Ozik J, Wozniak JM, Collier N, Macal CM, Binois M. A population data-driven workflow for COVID-19 modeling and learning. The International Journal of High Performance Computing Applications 2021;35(5):483–499. + + + Keskinocak P, Oruc BE, Baxter A, Asplund J, Serban N. The impact of social distancing on COVID19 spread: state of Georgia case study. PLoS One 2020;15(10):e0239798. + + + Chen J, Vullikanti A, Hoops S, et al. Medical costs of keeping the US economy open during COVID-19. Sci Rep 2020;10(1):18422. + + + Amari E, Rehm J, Goldner E, Fischer B. Nonmedical prescription opioid use and mental health and pain comorbidities: a narrative review. Can J Psychiatry 2011;56(8):495–502. + + + Cantu R, Fields-Johnson D, Savannah S. Applying a social determinants of health approach to the opioid epidemic. Health Promot Pract 2023;24(1):16–19. + + + Centers for Disease Control and Prevention. Overdose deaths accelerating during COVID-19. Available at: https://www.cdc.gov/media/releases/2020/p1218-overdose-deaths-covid-19.html Accessed June 10, 2022. + + + Northern Lights Group, LLC. Curis Meditor. Available at: https://curismeditor.com/. Accessed June 10, 2022. + + + Walonoski J, Kramer M, Nichols J, et al. Synthea: an approach, method, and software mechanism for generating synthetic patients and the synthetic electronic health care record. J Am Med Inform Assoc 2018;25(3):230–238. + + + Wheaton WD. 2005–2009 U.S. Synthetic Population Ver. 2. 2012. RTI International. Available at: https://www.rti.org/impact/rti-us-synthetic-household-population%E2%84%A2. Accessed February 2, 2023. + + + Troitzsch KG. Validating simulation models. In: Horton G, ed. Proceedings of the 18th European Simulation Multiconference. Erlangen, Germany: SCS; 2004:98–106. + + + Diallo SY, Wildman WJ, Shults FL, Tolk A. Human Simulation: Perspectives, Insights, and Applications. Berlin, Germany: Springer; 2019. + + + Government of the District of Columbia. DC Health Opioid Dashboard. Available at: https://dchealth.dc.gov/page/opioid-dashboard#. Accessed June 10, 2022. + + + Diallo SY, Shults FL, Wildman WJ. Minding morality: ethical artificial societies for public policy modeling. AI Soc 2021;36(1):49–57. + + + Government of the District of Columbia, Office of the Chief Medical Examiner. Opioid-related fatal overdoses: January 1, 2016 to April 30, 2020. Available at: https://ocme.dc.gov/sites/default/files/dc/sites/ocme/agency_content/Opioid%20related%20Overdoses%20Deaths%20Rev%208.14.2020.pdf. Accessed June 10, 2022. + + + Washington Post. Rise in fatal drug overdoses in DC region likely tied to pandemic, officials say. Available at: https://www.washingtonpost.com/local/drug-overdose-washington-coronavirus/2020/08/20/2a4c64b8-e0a4-11ea-ade1-28daf1a5e919_story.html. Accessed June 10, 2022. + + + Davis PK, O'Mahony A, Pfautz J. Social-Behavioral Modeling for Complex Systems. Hoboken, NJ: John Wiley & Sons; 2019. + + + +
+ + + 36809359 + + 2023 + 02 + 22 + +
+ + 1932-6203 + + 18 + 2 + + 2023 + + + PloS one + PLoS One + + Idealism as an educational philosophy of mathematics teachers in Al Ain City Schools of the United Arab Emirates. + + e0279576 + + 10.1371/journal.pone.0279576 + + Educational philosophy, in general, is at the heart of the growth of education. It outlines the institution's goals, subject matters, teaching methods, roles of teachers as well as the role of students, assessment methods, and teaching/learning experiences. The study aimed to identify the educational philosophical implications of idealism in schools in Al Ain city of the United Arab Emirates from the perspectives of mathematics teachers. The researchers used a questionnaire with thirty-two Likert-type items as a quantitative method for data collection. The instrument was administered to a randomly selected sample of 82 (46 male and 36 female) mathematics teachers in Al Ain city. The data were analyzed in IBM SPSS version 28 for one sample t-tests and independent samples t-tests to compare teachers' perceptions of curriculum, education values, school functions, roles of teachers, and teaching methods with gender and school type. Further analyses included a one-way ANOVA for teaching experiences and teaching cycles, bivariate correlations between the variables, and a generalized linear model to identify the significant predictors of the teaching method. The findings of the study showed that mathematics teachers in Al Ain city embrace an idealistic philosophy of curriculum, educational values, the role of schools and teachers, and teaching methods in general. The teachers' perceptions of the curriculum and school functions were found to be significant predictors of their teaching methods. These findings have both pedagogical and curricular implications. + Copyright: © 2023 Khasawneh et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Khasawneh + Omar M + OM + + College of Education, Yarmouk University-Irbid, Irbid, Jordan. + + + + Jarrah + Adeeb M + AM + https://orcid.org/0000-0002-8216-8848 + + Department of Curriculum and Instruction, Emirates College for Advanced Education, Khalifa City, Abu Dhabi, United Arab Emirates (UAE). + + + + Bani Hani + Mohammad S + MS + https://orcid.org/0000-0002-3305-115X + + College of Education, Yarmouk University-Irbid, Irbid, Jordan. + + + + Belbase + Shashidhar + S + https://orcid.org/0000-0003-3722-756X + + Department of Curriculum and Instruction, College of Education, United Arab Emirates University, Al Ain, United Arab Emirates (UAE). + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 01 + 22 + + + 2022 + 12 + 09 + + + 2023 + 2 + 22 + 13 + 43 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809359 + 10.1371/journal.pone.0279576 + PONE-D-22-01954 + + +
+ + + 36809362 + + 2023 + 02 + 22 + +
+ + 1935-2735 + + 17 + 2 + + 2023 + Feb + 21 + + + PLoS neglected tropical diseases + PLoS Negl Trop Dis + + Modelling modifiable factors associated with the probability of human rabies deaths among self-reported victims of dog bites in Abuja, Nigeria. + + e0011147 + + 10.1371/journal.pntd.0011147 + + Canine-mediated rabies kills tens of thousands of people annually in lesser-developed communities of Asia, Africa, and the Americas, primarily through bites from infected dogs. Multiple rabies outbreaks have been associated with human deaths in Nigeria. However, the lack of quality data on human rabies hinders advocacy and resource allocation for effective prevention and control. We obtained 20 years of dog bite surveillance data across 19 major hospitals in Abuja, incorporating modifiable and environmental covariates. To overcome the challenge of missing information, we used a Bayesian approach with expert-solicited prior information to jointly model missing covariate data and the additive effects of the covariates on the predicted probability of human death after rabies virus exposure. Only 1155 cases of dog bites were recorded throughout the study period, out of which 4.2% (N = 49) died of rabies. The odds for risk of human death were predicted to decrease among individuals who were bitten by owned dogs compared to those bitten by free-roaming dogs. Similarly, there was a predicted decrease in the probability of human death among victims bitten by vaccinated dogs compared to those bitten by unvaccinated dogs. The odds for the risk of human death after bitten individuals received rabies prophylaxis were predicted to decrease compared to no prophylaxis. We demonstrate the practical application of a regularised Bayesian approach to model sparse dog bite surveillance data to uncover risk factors for human rabies, with broader applications in other endemic rabies settings with similar profiles. The low reporting observed in this study underscores the need for community engagement and investment in surveillance to increase data availability. Better data on bite cases will help to estimate the burden of rabies in Nigeria and would be important to plan effective prevention and control of this disease. + Copyright: © 2023 Mshelbwala et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Mshelbwala + Philip P + PP + https://orcid.org/0000-0002-6834-1456 + + School of Veterinary Science, The University of Queensland, Gatton, Australia. + + + Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Abuja, Abuja, Nigeria. + + + + J Soares Magalhães + Ricardo + R + + School of Veterinary Science, The University of Queensland, Gatton, Australia. + + + Children's Health and Environment Program, UQ Children's Health Research Centre, The University of Queensland, South Brisbane, Australia. + + + + Weese + J Scott + JS + + Department of Pathobiology, Ontario Veterinary College, Guelph, Canada. + + + + Ahmed + Nasir O + NO + + Nigeria Centre for Disease Control, Abuja, Nigeria. + + + + Rupprecht + Charles E + CE + + LYSSA LLC, Atlanta, Georgia, United States of America. + + + Auburn University, Auburn, Alabama, United States of America. + + + + Clark + Nicholas J + NJ + + School of Veterinary Science, The University of Queensland, Gatton, Australia. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS Negl Trop Dis + 101291488 + 1935-2727 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 04 + 06 + + + 2023 + 02 + 07 + + + 2023 + 2 + 22 + 13 + 44 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809362 + 10.1371/journal.pntd.0011147 + PNTD-D-22-00440 + + +
+ + + 36809353 + + 2023 + 02 + 22 + +
+ + 1553-7358 + + 19 + 2 + + 2023 + Feb + 21 + + + PLoS computational biology + PLoS Comput Biol + + Neural adaptation and fractional dynamics as a window to underlying neural excitability. + + e1010527 + + 10.1371/journal.pcbi.1010527 + + The relationship between macroscale electrophysiological recordings and the dynamics of underlying neural activity remains unclear. We have previously shown that low frequency EEG activity (<1 Hz) is decreased at the seizure onset zone (SOZ), while higher frequency activity (1-50 Hz) is increased. These changes result in power spectral densities (PSDs) with flattened slopes near the SOZ, which are assumed to be areas of increased excitability. We wanted to understand possible mechanisms underlying PSD changes in brain regions of increased excitability. We hypothesized that these observations are consistent with changes in adaptation within the neural circuit. We developed a theoretical framework and tested the effect of adaptation mechanisms, such as spike frequency adaptation and synaptic depression, on excitability and PSDs using filter-based neural mass models and conductance-based models. We compared the contribution of single timescale adaptation and multiple timescale adaptation. We found that adaptation with multiple timescales alters the PSDs. Multiple timescales of adaptation can approximate fractional dynamics, a form of calculus related to power laws, history dependence, and non-integer order derivatives. Coupled with input changes, these dynamics changed circuit responses in unexpected ways. Increased input without synaptic depression increases broadband power. However, increased input with synaptic depression may decrease power. The effects of adaptation were most pronounced for low frequency activity (< 1Hz). Increased input combined with a loss of adaptation yielded reduced low frequency activity and increased higher frequency activity, consistent with clinical EEG observations from SOZs. Spike frequency adaptation and synaptic depression, two forms of multiple timescale adaptation, affect low frequency EEG and the slope of PSDs. These neural mechanisms may underlie changes in EEG activity near the SOZ and relate to neural hyperexcitability. Neural adaptation may be evident in macroscale electrophysiological recordings and provide a window to understanding neural circuit excitability. + Copyright: © 2023 Lundstrom, Richner. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Lundstrom + Brian Nils + BN + https://orcid.org/0000-0002-5310-5549 + + Neurology Department, Mayo Clinic, Rochester, Minnesota, United States of America. + + + + Richner + Thomas J + TJ + + Neurology Department, Mayo Clinic, Rochester, Minnesota, United States of America. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS Comput Biol + 101238922 + 1553-734X + + IM + I have read the journal’s policy and the authors of this manuscript have the following competing interests: BNL declares intellectual property licensed to Cadence Neuroscience Inc (contractual rights waived; all funds to Mayo Clinic) and Seer Medical Inc (contractual rights waived; all funds to Mayo Clinic), site investigator (Medtronic EPAS, NeuroPace RESPONSE, Neuroelectrics tDCS for Epilepsy), and industry consultant (Epiminder, Medtronic, Neuropace, Philips Neuro; all funds to Mayo Clinic). +
+ + + + 2022 + 09 + 01 + + + 2023 + 01 + 29 + + + 2023 + 2 + 22 + 13 + 43 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809353 + 10.1371/journal.pcbi.1010527 + PCOMPBIOL-D-22-01304 + + +
+ + + 36809356 + + 2023 + 02 + 22 + +
+ + 1436-3771 + + + 2023 + Feb + 21 + + + Clinical oral investigations + Clin Oral Investig + + Effects of reducing excess dental adhesive on bacterial adhesion in the bracket periphery. + 10.1007/s00784-023-04924-4 + + White spot lesions are one of the most common side effects of orthodontic therapy with a multibracket appliance and may indicate a preliminary stage of caries, also known as initial caries. Several approaches may be utilized to prevent these lesions, such as reducing bacterial adhesion in the area surrounding the bracket. This bacterial colonization can be adversely affected by a number of local characteristics. In this context, the effects of excess dental adhesive in the bracket periphery were investigated by comparing a conventional bracket system with the APC flash-free bracket system. + Both bracket systems were applied to 24 extracted human premolars, and bacterial adhesion with Streptoccocus sobrinus (S. sobrinus) was performed for 24 h, 48 h, 7 d, and 14 d. After incubation, bacterial colonization was examined in specific areas by electron microscopy. + Overall, significantly fewer bacterial colonies were found in the adhesive area around the APC flash-free brackets (n = 507 ± 13 bacteria) than the conventionally bonded bracket systems (n = 850 ± 56 bacteria). This is a significant difference (**p = 0.004). However, APC flash-free brackets tend to create marginal gaps with more bacterial adhesion in this area than conventional bracket systems (n = 265 ± 31 bacteria). This bacterial accumulation in the marginal-gap area is also significant (*p = 0.029). + A smooth adhesive surface with minimal adhesive excess is beneficial for reducing bacterial adhesion but also poses a risk of marginal gap formation with subsequent bacterial colonization, which can potentially trigger carious lesions. + To reduce bacterial adhesion, the APC flash-free bracket adhesive system with low adhesive excess might be beneficial. APC flash-free brackets reduce the bacterial colonization in the bracket environment. A lower number of bacteria can minimize white spot lesions in the bracket environment. APC flash-free brackets tend to form marginal gaps between the bracket adhesive and the tooth. + © 2023. The Author(s). + + + + Hennig + Christoph-Ludwig + CL + http://orcid.org/0000-0002-7776-1129 + + Department of Orthodontics, Center of Dental Medicine, University Hospital Jena, An Der Alten Post 4, 07743, Jena, Germany. Christoph-Ludwig.Hennig@med.uni-jena.de. + + + + Blochberger + Bijan + B + + Department of Orthodontics, Center of Dental Medicine, University Hospital Jena, An Der Alten Post 4, 07743, Jena, Germany. + + + + Symmank + Judit + J + + Department of Orthodontics, Center of Dental Medicine, University Hospital Jena, An Der Alten Post 4, 07743, Jena, Germany. + + + + Nitzsche + Ánn + Á + + Department of Orthodontics, Center of Dental Medicine, University Hospital Jena, An Der Alten Post 4, 07743, Jena, Germany. + + + + Nietzsche + Sandor + S + + Electron Microscopy Center, University Hospital Jena, Ziegelmühlenweg 1, 07743, Jena, Germany. + + + + Steiniger + Frank + F + + Electron Microscopy Center, University Hospital Jena, Ziegelmühlenweg 1, 07743, Jena, Germany. + + + + Dederichs + Marco + M + + Department of Prosthodontics, Center of Dental Medicine, University Hospital Jena, An Der Alten Post 4, 07743, Jena, Germany. + + + + Güllmar + André + A + + Department of Conservative Dentistry and Periodontology, Center of Dental Medicine, University Hospital Jena, An Der Alten Post 4, 07743, Jena, Germany. + + + + Reise + Markus + M + + Department of Conservative Dentistry and Periodontology, Center of Dental Medicine, University Hospital Jena, An Der Alten Post 4, 07743, Jena, Germany. + + + + Schulze-Späte + Ulrike + U + + Department of Conservative Dentistry and Periodontology, Center of Dental Medicine, University Hospital Jena, An Der Alten Post 4, 07743, Jena, Germany. + + + Section of Geriodontics, Department of Conservative Dentistry and Periodontology, Center of Dental Medicine, University Hospital Jena, An Der Alten Post 4, 07743, Jena, Germany. + + + + Sigusch + Bernd + B + + Department of Conservative Dentistry and Periodontology, Center of Dental Medicine, University Hospital Jena, An Der Alten Post 4, 07743, Jena, Germany. + + + + Jacobs + Collin + C + + Department of Orthodontics, Center of Dental Medicine, University Hospital Jena, An Der Alten Post 4, 07743, Jena, Germany. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Clin Oral Investig + 9707115 + 1432-6981 + + + Bacterial adhesion + Biofilm formation + Bracket periphery + Flash-free brackets + White spot lesion + +
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Angle Orthod 83(4):641–647. https://doi.org/10.2319/071712-584.1 + + 10.2319/071712-584.1 + 23289733 + 8754044 + + + + O’Reilly MM, Featherstone JD (1987) Demineralization and remineralization around orthodontic appliances: an in vivo study. Am J Orthod Dentofac Orthop 92(1):33–40. https://doi.org/10.1016/0889-5406(87)90293-9 + + 10.1016/0889-5406(87)90293-9 + + + + Weitman RT, Eames WB (1975) Plaque accumulation on composite surfaces after various finishing procedures. Oral Health 65(12):29–33 + + 1074131 + + + + Anhoury P, Nathanson D, Hughes CV, Socransky S, Feres M, Chou LL (2002) Microbial profile on metallic and ceramic bracket materials. Angle Orthod 72(4):338–343. https://doi.org/10.1043/0003-3219(2002)072%3c0338:MPOMAC%3e2.0.CO;2 + + 10.1043/0003-3219(2002)072<0338:MPOMAC>2.0.CO;2 + 12169034 + + + + ElSherifa MT, Shamaa MS, Montasser MA (2020) Enamel around orthodontic brackets coated with flash-free and conventional adhesives. J Orofac Orthop 81(6):419–426. https://doi.org/10.1007/s00056-020-00241-7 + + 10.1007/s00056-020-00241-7 + 32696069 + + + + Sukontapatipark W, El-Agroudi MA, Selliseth NJ, Thunold K, Selvig KA (2001) Bacterial colonization associated with fixed orthodontic appliances. A scanning electron microscopy study. Eur J Orthod 23(5):475–484. https://doi.org/10.1093/ejo/23.5.475 + + 10.1093/ejo/23.5.475 + 11668867 + + + + Grünheid T, Sudit GN, Larson BE (2015) Debonding and adhesive remnant cleanup: an in vitro comparison of bond quality, adhesive remnant cleanup, and orthodontic acceptance of a flash-free product. Eur J Orthod 37(5):497–502. https://doi.org/10.1093/ejo/cju080 + + 10.1093/ejo/cju080 + 25548144 + + + + Grünheid T, Larson BE (2018) A comparative assessment of bracket survival and adhesive removal time using flash-free or conventional adhesive for orthodontic bracket bonding: a split-mouth randomized controlled clinical trial. Am J Orthod Dentofacial Orthop 154(5):621–628. https://doi.org/10.1016/j.ajodo.2018.05.012 + + 10.1016/j.ajodo.2018.05.012 + 30384932 + + + + Soliman TA, Ghorab S, Baeshen H (2022) Effect of surface treatments and flash-free adhesive on the shear bond strength of ceramic orthodontic brackets to CAD/CAM provisional materials. Clin Oral Invest 26(1):481–492. https://doi.org/10.1007/s00784-021-04022-3 + + 10.1007/s00784-021-04022-3 + + + + König KG (1971) Kariesprophylaxe gestern, heute, morgen [Caries prophylaxis in the past, present and future]. Osterreichische Z Stomatol 68(9):382–386 + + + Kim J, Kanavakis G, Finkelman MD, Lee M (2016) Microleakage under ceramic flash-free orthodontic brackets after thermal cycling. Angle Orthod 86(6):905–908. https://doi.org/10.2319/021016-115.1 + + 10.2319/021016-115.1 + 27182779 + 8597331 + + + + Ash S, Hay N (1996) Adhesive pre-coated brackets, a comparative clinical study. Br J Orthod 23(4):325–329. https://doi.org/10.1179/bjo.23.4.325 + + 10.1179/bjo.23.4.325 + 8985569 + + + + Wong M, Power S (2003) A prospective randomized clinical trial to compare pre-coated and non-pre-coated brackets. J Orthod 30(2):155–128. https://doi.org/10.1093/ortho/30.2.155 + + 10.1093/ortho/30.2.155 + 12835432 + + + + +
+ + + 36809361 + + 2023 + 02 + 22 + +
+ + 1932-6203 + + 18 + 2 + + 2023 + + + PloS one + PLoS One + + Multi‑objective optimization of nitrile rubber and thermosets modified bituminous mix using desirability approach. + + e0281418 + + 10.1371/journal.pone.0281418 + + A variety of materials, including waste and rubber products, have been used in road construction to improve the performance of bituminous pavements. The present investigation is focused on modifying bitumen using Nitrile rubber (NBR) with different thermosets namely Bakelite (B), Furan Resin (FR), and Epoxy resin (ER). The emphasis of the problem is to arrive at a mix to achieve maximum Marshall Stability (MS) and minimum flow value of Modified Bituminous Concrete. Taguchi DOE technique has been used to design the experiments using Minitab software. Analysis of Variance (ANOVA) and Multi-objective optimization has been performed using the desirability approach in Design expert software. ANOVA analysis predicts that NBR, B, ER, and FR are the major significant parameters for Marshall Stability (MS) and Flow Value (FV). It has also been analyzed from SEM and EDS images of modified bitumen that sample S1 (5% NBR, 10% Bakelite, 10% FR, 2.5% ER) has a fine surface with small pores as compared to sample S34 (10% NBR, 0% Bakelite 10% FR, 2.5% ER). Multi-optimization results suggested the optimal conditions are achieved at NBR-7.6%, Bakelite-4.8%, FR-2.5%, and ER-2.6% for MS and FV. The maximum MS is 14.84 KN and the minimum FV is 2.84 mm is obtained using optimum conditions. To validate the optimization results, the confirmation runs have been conducted, and obtained results are within 5% error with optimal conditions. + Copyright: © 2023 Chopra et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Chopra + Avani + A + + Department of Civil Engineering, Chandigarh University, Mohali, Punjab, India. + + + + Singh + Sandeep + S + + Department of Civil Engineering, Chandigarh University, Mohali, Punjab, India. + + + + Kanoungo + Abhishek + A + + Department of Civil Engineering, Chitkara School of Engineering & Technology, Chitkara University, Himachal Pradesh, India. + + + + Singh + Gurpreet + G + + Department of Mechanical Engineering, Chandigarh University, Mohali, Punjab, India. + + + + Gupta + Naveen Kumar + NK + + Mechanical Engineering Department, Institute of Engineering and Technology, GLA University, Mathura, UP, India. + + + + Sharma + Shubham + S + + Mechanical Engineering Department, University Centre for Research and Development, Chandigarh University, Mohali, Punjab, India. + + + School of Mechanical and Automotive Engineering, Qingdao University of Technology, Qingdao, China. + + + + Joshi + Sanjeev Kumar + SK + + Uttaranchal Institute of Technology, Uttaranchal University, Dehradun, India. + + + + Eldin + Sayed M + SM + https://orcid.org/0000-0003-3151-9967 + + Center of Research, Faculty of Engineering, Future University in Egypt, New Cairo, Egypt. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 11 + 15 + + + 2023 + 01 + 24 + + + 2023 + 2 + 22 + 13 + 43 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809361 + 10.1371/journal.pone.0281418 + PONE-D-22-31489 + + +
+ + + 36809364 + + 2023 + 02 + 22 + +
+ + 1528-1159 + + + 2023 + Feb + 20 + + + Spine + Spine (Phila Pa 1976) + + Postoperative Dural Sac Cross-sectional Area as an Association for Outcome after Surgery for Lumbar Spinal Stenosis. Clinical and Radiological Results from the Nordsten-spinal Stenosis Trial. + 10.1097/BRS.0000000000004565 + + Prospective cohort study. + To investigate the association between postoperative Dural Sac Cross-sectional Area (DSCA) after decompressive surgery for Lumbar Spinal Stenosis (LSS), and clinical outcome. Furthermore, to investigate if there is a minimum threshold for how extensive a posterior decompression needs to be to achieve a satisfactory clinical result. + There is limited scientific evidence for how extensive a lumbar decompression needs to be to obtain a good clinical outcome in patients with symptomatic LSS. + All patients were included from the Spinal Stenosis Trial (SST) of the NORwegian Degenerative spondylolisthesis and spinal STENosis (NORDSTEN)-study. The patients underwent decompression according to 3 different methods. DSCA measured on lumbar MRI at baseline and at three months follow up, and patient reported outcome at baseline and at two-year follow up were registered in a total of 393 patients. Mean age was 68 (SD 8.3), proportion of males were 204/393 (52%), proportion of smokers were 80/393 (20%), and mean BMI was 27.8 (SD 4.2).The cohort was divided into quintiles based on the achieved DSCA postoperatively, numeric, and relative increase of DSCA, and the association between the increase in DSCA and clinical outcome were evaluated. + At baseline, the mean DSCA in the whole cohort was 51.1 mm2 (SD 21.1). Postoperatively the area increased to a mean area of 120.6 mm2 (SD 46.9). The change in ODI in the quintile with the largest DSCA was -22.0 (95% CI: -25.6 - -18), and in the quintile with the lowest DSCA the ODI change was -18.9 (95% CI: -22.4 - -15.3). There were only minor differences in clinical improvement for patients in the different DSCA quintiles. + Less aggressive decompression performed similarly to wider decompression across multiple different patient-reported outcome measures at 2 years following surgery. + Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. + + + + Hermansen + Erland + E + + Department of Orthopedic Surgery, Ålesund Hospital, Møre and Romsdal Hospital Trust. + + + Kysthospitalet in Hagevik. Orthopedic Clinic, Haukeland University Hospital, Bergen. + + + Department of Clinical Medicine, University of Bergen, Bergen, Norway. + + + + Myklebust + Tor Åge + + + Department of Research and Innovation, Møre and Romsdal Hospital Trust, Ålesund, Norway. + + + Department of Registration, Cancer Registry Norway, Oslo, Norway. + + + + Weber + Clemens + C + + Department of Neurosurgery, Stavanger University Hospital. + + + Department of Quality and Health Technology, University of Stavanger. + + + + Brisby + Helena + H + + Dept of Orthopedics, Sahlgrenska University Hospital, Gothenburg, Sweden. + + + Dept. of Orthopedics, Institute for clinical sciences, Sahlgrenska Academy, University of Gothenburg, Sweden. + + + + Austevoll + Ivar Magne + IM + + Kysthospitalet in Hagevik. Orthopedic Clinic, Haukeland University Hospital, Bergen. + + + + Hellum + Christian + C + + Division of Orthopedic Surgery, Oslo University Hospital Ullevål, Oslo, Norway. + + + + Storheim + Kjersti + K + + Communication and Research Unit for Musculoskeletal Health (FORMI), Oslo University Hospital Oslo, Norway. + + + + Aaen + Jørn + J + + Department of Orthopedic Surgery, Ålesund Hospital, Møre and Romsdal Hospital Trust. + + + Department of Circulation and Medical Imaging, Faculty of medicine and health sciences, Norwegian University of Science and Technology. + + + + Banitalebi + Hasan + H + + Department of Diagnostic Imaging, Akershus University Hospital. + + + Institute of Clinical Medicine, University of Oslo, Oslo, Norway. + + + + Brox + Jens Ivar + JI + + Department of Physical Medicine and Rehabilitation, Oslo University Hospital. + + + + Grundnes + Oliver + O + + Department of Orthopedics, Akershus University Hospital. + + + + Rekeland + Frode + F + + Kysthospitalet in Hagevik. Orthopedic Clinic, Haukeland University Hospital, Bergen. + + + Department of Clinical Medicine, University of Bergen, Bergen, Norway. + + + + Solberg + Tore + T + + Department of Neurosurgery and the Norwegian Registry for spine surgery (NORspine), University Hospital of Northern Norway. + + + Institute of Clinical Medicine, The Arctic University of Norway. + + + + Franssen + Eric + E + + Department of Orthopedic surgery, Stavanger University Hospital. + + + + Indrekvam + Kari + K + + Kysthospitalet in Hagevik. Orthopedic Clinic, Haukeland University Hospital, Bergen. + + + Department of Clinical Medicine, University of Bergen, Bergen, Norway. + + + + eng + + Journal Article + + + 2023 + 02 + 20 + +
+ + United States + Spine (Phila Pa 1976) + 7610646 + 0362-2436 + + IM + "The authors report no conflicts of interest." +
+ + + + 2022 + 09 + 19 + + + 2022 + 12 + 01 + + + 2023 + 2 + 22 + 13 + 44 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809364 + 10.1097/BRS.0000000000004565 + 00007632-990000000-00242 + + +
+ + + 36809357 + + 2023 + 02 + 22 + +
+ + 1553-7404 + + 19 + 2 + + 2023 + Feb + 21 + + + PLoS genetics + PLoS Genet + + The identification of mediating effects using genome-based restricted maximum likelihood estimation. + + e1010638 + + 10.1371/journal.pgen.1010638 + + Mediation analysis is commonly used to identify mechanisms and intermediate factors between causes and outcomes. Studies drawing on polygenic scores (PGSs) can readily employ traditional regression-based procedures to assess whether trait M mediates the relationship between the genetic component of outcome Y and outcome Y itself. However, this approach suffers from attenuation bias, as PGSs capture only a (small) part of the genetic variance of a given trait. To overcome this limitation, we developed MA-GREML: a method for Mediation Analysis using Genome-based Restricted Maximum Likelihood (GREML) estimation. Using MA-GREML to assess mediation between genetic factors and traits comes with two main advantages. First, we circumvent the limited predictive accuracy of PGSs that regression-based mediation approaches suffer from. Second, compared to methods employing summary statistics from genome-wide association studies, the individual-level data approach of GREML allows to directly control for confounders of the association between M and Y. In addition to typical GREML parameters (e.g., the genetic correlation), MA-GREML estimates (i) the effect of M on Y, (ii) the direct effect (i.e., the genetic variance of Y that is not mediated by M), and (iii) the indirect effect (i.e., the genetic variance of Y that is mediated by M). MA-GREML also provides standard errors of these estimates and assesses the significance of the indirect effect. We use analytical derivations and simulations to show the validity of our approach under two main assumptions, viz., that M precedes Y and that environmental confounders of the association between M and Y are controlled for. We conclude that MA-GREML is an appropriate tool to assess the mediating role of trait M in the relationship between the genetic component of Y and outcome Y. Using data from the US Health and Retirement Study, we provide evidence that genetic effects on Body Mass Index (BMI), cognitive functioning and self-reported health in later-life run partially through educational attainment. For mental health, we do not find significant evidence for an indirect effect through educational attainment. Further analyses show that the additive genetic factors of these four outcomes do partially (cognition and mental health) and fully (BMI and self-reported health) run through an earlier realization of these traits. + Copyright: © 2023 Rietveld et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Rietveld + Cornelius A + CA + https://orcid.org/0000-0003-4053-1861 + + Department of Applied Economics, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, The Netherlands. + + + Erasmus University Rotterdam Institute for Behavior and Biology, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, The Netherlands. + + + + de Vlaming + Ronald + R + https://orcid.org/0000-0001-6416-6067 + + Department of Economics, School of Business and Economics, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. + + + + Slob + Eric A W + EAW + https://orcid.org/0000-0002-1644-0735 + + Department of Applied Economics, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, The Netherlands. + + + Erasmus University Rotterdam Institute for Behavior and Biology, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, The Netherlands. + + + Medical Research Council Biostatistics Unit, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS Genet + 101239074 + 1553-7390 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 06 + 24 + + + 2023 + 01 + 23 + + + 2023 + 2 + 22 + 13 + 43 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809357 + 10.1371/journal.pgen.1010638 + PGENETICS-D-22-00746 + + +
+ + + 36809355 + + 2023 + 02 + 22 + +
+ + 1436-3771 + + + 2023 + Feb + 21 + + + Clinical oral investigations + Clin Oral Investig + + Effect of whitening products on sound enamel and on artificial caries lesions during a cariogenic challenge. + 10.1007/s00784-023-04916-4 + + To investigate the effect of fluoride-containing whitening products on sound enamel and on artificial caries lesions during a cariogenic challenge. + Bovine enamel specimens (n = 120) with three areas [non-treated sound enamel (NSE), treated sound enamel (TSE), and treated artificial caries lesion (TACL)] were randomly assigned to the four groups: whitening mouthrinse (WM: 2.5% hydrogen peroxide-100 ppm F-), placebo mouthrinse (PM: 0% hydrogen peroxide-100 ppm F-), whitening gel (WG: 10% carbamide peroxide-1130 ppm F-), and deionized water (negative control; NC). The treatments (2 min for WM, PM, and NC, and 2 h for WG) were carried out during a 28-day pH-cycling model (6 × 60 min demineralization/day). Relative surface reflection intensity (rSRI) and transversal microradiography (TMR) analyses were performed. Fluoride uptake (surface and subsurface) was measured in additional enamel specimens. + For TSE, a higher value of rSRI was observed in WM (89.99% ± 6.94), and a greater decrease in rSRI was observed for WG and NC, and no sign of mineral loss was verified for all groups (p > 0.05). For TACL, rSRI significantly decreased after pH-cycling for all experimental groups with no difference between them (p < 0.05). Higher amounts of fluoride were found in WG. WG and WM exhibited intermediate values of mineral loss, similar to PM. + The whitening products did not potentialize the enamel demineralization under a severe cariogenic challenge, and they did not exacerbate mineral loss of the artificial caries lesions. + Low concentrated hydrogen peroxide whitening gel and mouthrinse containing fluoride do not intensify the progression of caries lesions. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Mailart + M C + MC + http://orcid.org/0000-0001-8967-0374 + + Department of Restorative Dentistry, Institute of Science and Technology, São Paulo State University, Avenida Engenheiro Francisco José Longo, 777, Jardim São Dimas, São José Dos Campos, SP, 12245-000, Brazil. + + + Department of Restorative, Preventive and Pediatric Dentistry, School of Dental Medicine, University of Bern, Freiburgstrasse 7, 3010, Bern, CH, Switzerland. + + + + Borges + A B + AB + http://orcid.org/0000-0001-7686-089X + + Department of Restorative Dentistry, Institute of Science and Technology, São Paulo State University, Avenida Engenheiro Francisco José Longo, 777, Jardim São Dimas, São José Dos Campos, SP, 12245-000, Brazil. alessandra.buhler@unesp.br. + + + + Wierichs + R J + RJ + http://orcid.org/0000-0002-4239-199X + + Department of Restorative, Preventive and Pediatric Dentistry, School of Dental Medicine, University of Bern, Freiburgstrasse 7, 3010, Bern, CH, Switzerland. + + + + Torres + C R G + CRG + http://orcid.org/0000-0002-9485-5514 + + Department of Restorative Dentistry, Institute of Science and Technology, São Paulo State University, Avenida Engenheiro Francisco José Longo, 777, Jardim São Dimas, São José Dos Campos, SP, 12245-000, Brazil. + + + + Carvalho + T S + TS + http://orcid.org/0000-0002-2435-1169 + + Department of Restorative, Preventive and Pediatric Dentistry, School of Dental Medicine, University of Bern, Freiburgstrasse 7, 3010, Bern, CH, Switzerland. + + + + eng + + + 2020/13036-7 + Fundação de Amparo à Pesquisa do Estado de São Paulo + + + + #304110/2020-5 + Conselho Nacional de Desenvolvimento Científico e Tecnológico + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Clin Oral Investig + 9707115 + 1432-6981 + + + At-home bleaching + Enamel + Fluoride + Initial caries lesions + Whitening mouthrinse + pH-cycling + +
+ + + + 2022 + 11 + 18 + + + 2023 + 02 + 03 + + + 2023 + 2 + 22 + 13 + 43 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809355 + 10.1007/s00784-023-04916-4 + 10.1007/s00784-023-04916-4 + + + + Mailart MC, Sakassegawa PA, Santos KC et al (2021) One-year follow-up comparing at-home bleaching systems outcomes and the impact on patient’s satisfaction: randomized clinical trial. J Esthet Restor Dent 33:1175–1185 + + 34453873 + 10.1111/jerd.12814 + + + + Aka B, Celik EU (2017) Evaluation of the efficacy and color stability of two different at-home bleaching systems on teeth of different shades: a randomized controlled clinical trial. J Esthet Restor Dent 29:325–338 + + 28322505 + 10.1111/jerd.12296 + + + + Demarco FF, Meireles SS, Masotti AS (2009) Over-the-counter whitening agents: a concise review. Braz Oral Res 23:64–70 + + 19838560 + 10.1590/S1806-83242009000500010 + + + + Hegedüs C, Bistey T, Flóra-Nagy E et al (1999) An atomic force microscopy study on the effect of bleaching agents on enamel surface. J Dent 27:509–515 + + 10507207 + 10.1016/S0300-5712(99)00006-8 + + + + Cakir FY, Korkmaz Y, Firat E et al (2011) Chemical analysis of enamel and dentin following the application of three different at-home bleaching systems. Oper Dent 36:529–536 + + 21834707 + 10.2341/11-050-L + + + + Cavalli V, Rodrigues LKA, Paes-Leme AF et al (2011) Effects of the addition of fluoride and calcium to low-concentrated carbamide peroxide agents on the enamel surface and subsurface. Photomed Laser Surg 29:319–325 + + 21204703 + 10.1089/pho.2010.2797 + + + + Jurema ALB, de Souza MY, Torres CRG et al (2018) Effect of pH on whitening efficacy of 35% hydrogen peroxide and enamel microhardness. J Esthet Restor Dent 30:E39–E44 + + 29392894 + 10.1111/jerd.12367 + + + + Bistey T, Nagy IP, Simó A, Hegedus C (2007) In vitro FT-IR study of the effects of hydrogen peroxide on superficial tooth enamel. J Dent 35:325–330 + + 17116354 + 10.1016/j.jdent.2006.10.004 + + + + Kim Y, Son HH, Yi K et al (2016) Bleaching effects on color, chemical, and mechanical properties of white spot lesions. Oper Dent 41:318–326 + + 26669503 + 10.2341/15-015-L + + + + Al-Shahrani AA, Levon JA, Hara AT et al (2020) The ability of dual whitening anti-caries mouthrinses to remove extrinsic staining and enhance caries lesion remineralization – an in vitro study. J Dent 103S:100022 + + 34059305 + 10.1016/j.jjodo.2020.100022 + + + + Borges AB, Yui KCK, D’Avila TC et al (2010) Influence of remineralizing gels on bleached enamel microhardness in different time intervals. Oper Dent 35:180–186 + + 20420061 + 10.2341/09-117-L + + + + Robinson C, Hallsworth A, Shore R, Kirkham J (1990) Effect of surface zone deproteinisation on the access of mineral ions into subsurface carious lesions of human enamel. Caries Res 24:226–230 + + 2276155 + 10.1159/000261272 + + + + Salomão DLF, Santos DM, Nogueira RD et al (2014) Acid demineralization susceptibility of dental enamel submitted to different bleaching techniques and fluoridation regimens. Oper Dent 39:E178–E185 + + 24673418 + 10.2341/13-140 + + + + Zero D, Rahbek I, Fu J et al (1990) Comparison of the iodide permeability test, the surface microhardness test, and mineral dissolution of bovine enamel following acid challenge. Caries Res 24:181–188 + + 2364403 + 10.1159/000261263 + + + + Niemeyer SH, Baumann T, Lussi A et al (2021) Salivary pellicle modification with polyphenol-rich teas and natural extracts to improve protection against dental erosion. 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J Biomed Opt 16:107002 + + 22029364 + 3206927 + 10.1117/1.3631791 + + + + Sieber KR, Schmidt C, Baumann T et al (2019) Acquired enamel pellicle modification with casein and mucin in different concentrations and its impact on initial dental erosion. Caries Res 53:457–466 + + 31085905 + 10.1159/000499579 + + + + Carvalho TS, Pham KN, Niemeyer SH, Baumann T (2021) The effect of red wine in modifying the salivary pellicle and modulating dental erosion kinetics. Eur J Oral Sci 129:e12749 + + 33381873 + 10.1111/eos.12749 + + + + Carvalho TS, Bönecker M, Altenburger MJ et al (2015) Fluoride varnishes containing calcium glycerophosphate: fluoride uptake and the effect on in vitro enamel erosion. Clin Oral Investig 19:1429–1436 + + 25416637 + 10.1007/s00784-014-1363-6 + + + + Wierichs RJ, Musiol J, Erdwey D et al (2020) Re- and demineralization characteristics of dentin depending on fluoride application and baseline characteristics in situ. J Dent 94:103305 + + 32112909 + 10.1016/j.jdent.2020.103305 + + + + Altenburger MJ, Schirrmeister JF, Lussi A et al (2009) In situ fluoride retention and remineralization of incipient carious lesions after the application of different concentrations of fluoride. Eur J Oral Sci 117:58–63 + + 19196319 + 10.1111/j.1600-0722.2008.00585.x + + + + Borges A, de Abreu F, Mailart M et al (2021) Efficacy and safety of bleaching gels according to application protocol. Oper Dent 46:E105–E116 + + 34086959 + 10.2341/19-253-L + + + + Berger SB, Pavan S, dos Santos PH et al (2012) Effect of bleaching on sound enamel and with early artificial caries lesions using confocal laser microscopy. Braz Dent J 23:110–115 + + 22666767 + 10.1590/S0103-64402012000200004 + + + + Basting RT, Rodrigues AL, Serra MC (2003) The effects of seven carbamide peroxide bleaching agents on enamel microhardness over time. J Am Dent Assoc 134:1335–1342 + + 14620012 + 10.14219/jada.archive.2003.0047 + + + + Xu B, Li Q, Wang Y (2011) Effects of pH values of hydrogen peroxide bleaching agents on enamel surface properties. Oper Dent 36:554–562 + + 21859312 + 10.2341/11-045-1 + + + + Borges AB, Torres CRG, de Souza PAB et al (2012) Bleaching gels containing calcium and fluoride: effect on enamel erosion susceptibility. Int J Dent 2012:347848 + + 23193404 + 3501936 + 10.1155/2012/347848 + + + + Torres C, Bonicio G, Crastechini É et al (2018) Effect of whitening mouthrinses on enamel toothbrush abrasion. Am J Dent 31:285–289 + + 30658373 + + + + Carvalho T, Stauffacher S, Eick S et al (2021) Using an optical reflectometer to measure caries lesion activity on enamel. BMC Oral Health. https://doi.org/10.21203/rs.3.rs-1053628/v1 + + 10.21203/rs.3.rs-1053628/v1 + 33706734 + 7948342 + + + + Kidd E, Fejerskov O (2004) What constitutes dental caries? Histopathology of carious enamel and dentin related to the action of cariogenic biofilms. J Dent Res 83:C35–C38 + + 15286119 + 10.1177/154405910408301s07 + + + + Ando M, Shaikh S, Eckert G (2018) Determination of caries lesion activity: reflection and roughness for characterization of caries progression. Oper Dent 43:301–306 + + 29676973 + 10.2341/16-236-L + + + + Sullivan HR (1954) The solubility of enamel surfaces. J Dent Res 33:504–510 + + 13184039 + 10.1177/00220345540330041001 + + + + Mailart MC, Ferracioli C de S, Torres CRG et al (2020) Hydrogen peroxide degradation of bleaching systems with different trays: randomized clinical trial. Am J Dent 33:89–94 + + 32259414 + + + + Guilherme C, Lopes L, Bonissoni D et al (2002) Effect of bleaching agents on the hardness and morphology of enamel. J Esthet Restor Dent 14:24–30 + + 10.1111/j.1708-8240.2002.tb00144.x + + + + Santos LFTF, Torres CRG, Caneppele TMF et al (2016) Effect of home-bleaching gels modified by calcium and/or fluoride and the application of nano-hydroxyapatite paste on in vitro enamel erosion susceptibility. Acta Odontol Scand 74:121–126 + + 26083582 + 10.3109/00016357.2015.1053150 + + + + Andrade ACM, Tenuta LMA, Borges AB, Torres CRG (2021) Effect of a hydrogen peroxide bleaching agent with calcium and phosphorus-containing salts on enamel surface hardness and roughness. Am J Dent 34:215–221 + + 34370915 + + + + Duckworth RM, Maguire A, Omid N et al (2009) Effect of rinsing with mouthwashes after brushing with a fluoridated toothpaste on salivary fluoride concentration. Caries Res 43:391–396 + + 19776570 + 10.1159/000239753 + + + + Gao SS, Zhang S, Mei ML et al (2016) Caries remineralisation and arresting effect in children by professionally applied fluoride treatment - a systematic review. 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+ + + 36809363 + + 2023 + 02 + 22 + +
+ + 1471-8405 + + + 2023 + Feb + 21 + + + Occupational medicine (Oxford, England) + Occup Med (Lond) + + Psychometric properties of the HSE Indicator Tool: evidence from Argentina. + kqad010 + 10.1093/occmed/kqad010 + + The Health and Safety Executive's Management Standards Indicator Tool (MSIT) is a 35-item self-report questionnaire that assesses seven psychosocial risk factors associated with work-related stress. Although the instrument has been validated in the UK, Italy, Iran and Malta, no validation studies have been carried out in Latin America. + To examine the factor structure, validity and reliability of the MSIT among Argentine employees. + A sample of employees of different organizations from Rafaela and Rosario, Argentina, completed an anonymous questionnaire that included the Argentine MSIT and specific scales to measure job satisfaction, workplace resilience and perceived mental and physical health (12-item Short Form Health Survey). Confirmatory factor analysis was used to determine the factor structure of the Argentine MSIT. + A total of 532 employees participated in the study (74% response rate). After testing three measurement models, the final respecified model was composed of 24 items distributed in six factors (demands, control, manager support, peer support, relationships and role clarity), showing satisfactory fit indices. The original MSIT change factor was discarded. Composite reliability ranged from 0.70 to 0.82. Although all dimensions showed adequate discriminant validity, convergent validity for control, role clarity and relationships is a matter of concern (average variance extracted values ≤ 0.50). Criterion-related validity was demonstrated by significant correlations between the MSIT subscales and job satisfaction, workplace resilience and mental and physical health. + The Argentine version of the MSIT presents good psychometric properties for use among employees of the region. Further research is needed to provide more evidence on the convergent validity of the questionnaire. + © The Author(s) 2023. Published by Oxford University Press on behalf of the Society of Occupational Medicine. All rights reserved. For Permissions, please email: journals.permissions@oup.com. + + + + Vaamonde + J D + JD + 0000-0002-2205-5075 + + School of Society, State and Government, National University of Rafaela, Rafaela 2300, Argentina. + + + School of Psychology, National University of Rosario, Rosario 2000, Argentina. + + + + Giacobino + A + A + + School of Society, State and Government, National University of Rafaela, Rafaela 2300, Argentina. + + + National Scientific and Technical Research Council (CONICET), Rafaela 2300, Argentina. + + + + eng + + + Expte. Nº 220 + Universidad Nacional de Rafaela + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Occup Med (Lond) + 9205857 + 0962-7480 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 44 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809363 + 7049602 + 10.1093/occmed/kqad010 + + +
+ + + 36809358 + + 2023 + 02 + 22 + +
+ + 1932-6203 + + 18 + 2 + + 2023 + + + PloS one + PLoS One + + Relationship of masked obesity to self-reported lifestyle habits, ideal body image, and anthropometric measures in Japanese university students: A cross-sectional study. + + e0281599 + + 10.1371/journal.pone.0281599 + + Masked obesity (MO) is defined as a normal body mass index (BMI) with a high body fat percentage (%BF), and is associated with the onset of lifestyle-related diseases. However, little is known about the current status of MO. Therefore, we investigated the relationship of MO to physical characteristics and lifestyle habits among Japanese university students. + Between 2011 and 2019, we conducted a survey of 10,168 males and 4,954 females with BMI within the normal range (18.5 ≤ BMI < 25 kg/m2). MO was defined as %BF ≥ 20% in males and %BF ≥ 30% in females. Students completed a questionnaire containing items about lifestyle habits. Systolic and diastolic blood pressures were measured, and hypertension was defined as systolic above 140 mmHg and/or diastolic blood pressure above 90 mmHg. A multivariate logistic regression analysis was performed to evaluate the relationships as follows: the relationship of masked obesity to self-reported lifestyle habits, ideal body image, and anthropometric measures; the relationship between hypertension and body indices. + The proportion of students with MO in 2019 was 13.4% in males and 25.8% in females, and the proportion of females increased over time. MO was associated with desire for weight loss (odds ratio, 95% confidence interval: 1.76, 1.53-2.02), intake of five macronutrients (0.79, 0.67-0.93), rice and wheat intakes (1.22, 1.01-1.47), sleep duration of < 7hr (0.85, 0.74-0.98), and exercise habit (0.71, 0.63-0.81) in males; and with balanced diet intake (0.79, 0.64-0.99) and exercise habit (0.65, 0.51-0.82) in females. There was a significant association of MO with hypertension in males (1.29, 1.09-1.53). + The percentage of female students with MO increased during the study period, and in males, MO may be a risk factor for hypertension. These results suggest that intervention for MO is needed in Japanese university students. + Copyright: © 2023 Yamashiro et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Yamashiro + Kaito + K + https://orcid.org/0000-0002-7785-1490 + + Laboratory of Public Health, Faculty of Pharmacy, Kindai University, Higashi-Osaka, Osaka, Japan. + + + + Yamaguchi + Naho + N + + Laboratory of Public Health, Faculty of Pharmacy, Kindai University, Higashi-Osaka, Osaka, Japan. + + + + Sagawa + Kazunori + K + + Antiaging Center, Kindai University, Higashi-Osaka, Osaka, Japan. + + + + Tanei + Shigeharu + S + + Faculty of Pharmaceutical Sciences, Nihon Pharmaceutical University, Kitaadachi-gun, Saitama, Japan. + + + + Ogata + Fumihiko + F + + Laboratory of Public Health, Faculty of Pharmacy, Kindai University, Higashi-Osaka, Osaka, Japan. + + + + Nakamura + Takehiro + T + + Laboratory of Public Health, Faculty of Pharmacy, Kindai University, Higashi-Osaka, Osaka, Japan. + + + + Kawasaki + Naohito + N + https://orcid.org/0000-0002-9412-0868 + + Laboratory of Public Health, Faculty of Pharmacy, Kindai University, Higashi-Osaka, Osaka, Japan. + + + Antiaging Center, Kindai University, Higashi-Osaka, Osaka, Japan. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 09 + 10 + + + 2023 + 01 + 27 + + + 2023 + 2 + 22 + 13 + 43 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809358 + 10.1371/journal.pone.0281599 + PONE-D-22-25190 + + +
+ + + 36809354 + + 2023 + 02 + 22 + +
+ + 1436-3771 + + + 2023 + Feb + 21 + + + Clinical oral investigations + Clin Oral Investig + + Protective effect of Chromobacterium violaceum and violacein against bone resorption by periodontitis. + 10.1007/s00784-023-04891-w + + The aim of this study was to evaluate the potential protective effect of Chromobacterium violaceum and violacein against periodontitis, in experimental models. + A double-blind experimental study on the exposure to C. violaceum or violacein in experimentally ligature-induced periodontitis, as preventive factors against alveolar bone loss by periodontitis. Bone resorption was assessed by morphometry. Antibacterial potential of violacein was assessed in an in vitro assay. Its cytotoxicity and genotoxicity were evaluated using the Ames test and SOS Chromotest assay, respectively. + The potential of C. violaceum to prevent/limit bone resorption by periodontitis was confirmed. Daily exposure to 106 cells/ml in water intake since birth and only during the first 30 days of life significantly reduced bone loss from periodontitis in teeth with ligature. Violacein extracted from C. violaceum was efficient in inhibiting or limiting bone resorption and had a bactericidal effect against Porphyromonas gingivalis in the in vitro assay. + We conclude that C. violaceum and violacein have the potential to prevent or limit the progression of periodontal diseases, in an experimental model. + The effect of an environmental microorganism with potential action against bone loss in animal models with ligature-induced periodontitis represents the possibility of understanding the etiopathogenesis of periodontal diseases in populations exposed to C. violaceum and the possibility of new probiotics and antimicrobials. This would imply new preventive and therapeutic possibilities. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + da Silva Barbirato + Davi + D + + Laboratory of Molecular Radiobiology - Biophysics Institute Carlos Chagas Filho, Federal University of Rio de Janeiro, 373 Carlos Chagas Filho Avenue, G1-003, Cidade Universitária, Ilha Do Fundão, Rio de Janeiro, RJ, 21941-902, Brazil. davibarbirato@gmail.com. + + + + Fogacci + Mariana Fampa + MF + + Department of Clinical and Preventive Dentistry, Federal University of Pernambuco, Recife, PE, Brazil. + + + + Guimarães + Taísa Coelho + TC + + Department of Integrated Clinic, Division of Periodontics, Dental School, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. + + + + de Carvalho + Denise Pires + DP + + Laboratory of Endocrine Physiology Doris Rosenthal - Biophysics Institute Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. + + + + Rurr + Janine Cardoso + JC + + Laboratory of Radiation in Biology - Biophysics Institute Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. + + + + Takiya + Christina Maeda + CM + + Laboratory of Immunopathology, Biophysics Institute Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. + + + + Scharfstein + Julio + J + + Laboratory of Molecular Immunology - Biophysics Institute Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. + + + + da Costa Leitão + Alvaro Augusto + AA + + Laboratory of Molecular Radiobiology - Biophysics Institute Carlos Chagas Filho, Federal University of Rio de Janeiro, 373 Carlos Chagas Filho Avenue, G1-003, Cidade Universitária, Ilha Do Fundão, Rio de Janeiro, RJ, 21941-902, Brazil. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Clin Oral Investig + 9707115 + 1432-6981 + + + Bone resorption + Chromobacterium violaceum + Periodontitis + Prevention and control + Wistar, rats + +
+ + + + 2022 + 08 + 16 + + + 2023 + 02 + 01 + + + 2023 + 2 + 22 + 13 + 43 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809354 + 10.1007/s00784-023-04891-w + 10.1007/s00784-023-04891-w + + + + Boisbaudran LECOQ (1882) Matière colorante se formant dans la colle de farine. Comp Rend Acad Sci 94:562–563 + + + Strong FM (1944) Isolation of violacein. Science 100:2596–3287. https://doi.org/10.1126/science.100.2596.287 + + 10.1126/science.100.2596.287 + + + + August PR, Grossman TH, Minor C et al (2000) Sequence analysis and functional characterization of the violacein biosynthetic pathway from Chromobacterium violaceum. J Mol Microbiol Biotechnol 2:513–519 + + 11075927 + + + + de Vasconcelos ATR, de Almeida DF, Hungria M et al (2003) The complete genome sequence of Chromobacteriumviolaceum reveals remarkable and exploitable bacterial adaptability. Proc Natl Acad Sci USA. https://doi.org/10.1073/pnas.1832124100 + + + Hungria M, Astolfi-Filho S, Chueire LMO et al (2005) Genetic characterization of Chromobacterium isolates from black water environments in the Brazilian Amazon. Lett Appl Microbiol. https://doi.org/10.1111/j.1472-765X.2005.01724.x + + + Antonisamy P, Ignacimuthu S (2010) Immunomodulatory, analgesic and antipyretic effects of violacein isolated from Chromobacterium violaceum. Phytomedicine. https://doi.org/10.1016/j.phymed.2009.05.018 + + + Lopes SCP, Blanco YC, Justo GZ et al (2009) Violacein extracted from Chromobacteriumviolaceum inhibits Plasmodium growth in vitro and in vivo. Antimicrob Agents Chemother. https://doi.org/10.1128/AAC.00693-08 + + + Rettori D, Durán N (1998) Production, extraction and purification of violacein: an antibiotic pigment produced by Chromobacterium violaceum. 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+ + + 36809365 + + 2023 + 02 + 22 + +
+ + 1540-0514 + + + 2023 + Feb + 22 + + + Shock (Augusta, Ga.) + Shock + + High molecular weight hyaluronan - a potential adjuvant to fluid resuscitation in abdominal sepsis? + 10.1097/SHK.0000000000002089 + + While fluid resuscitation is fundamental in the treatment of sepsis-induced tissue hypo-perfusion, a sustained positive fluid balance is associated with excess mortality. Hyaluronan, an endogenous glycosaminoglycan with high affinity to water, has not been tested previously as adjuvant to fluid resuscitation in sepsis.In a prospective, parallel-grouped, blinded model of porcine peritonitis-sepsis, we randomized animals to intervention with adjuvant hyaluronan (add-on to standard therapy) (n = 8) or 0.9% saline (n = 8). After the onset of hemodynamic instability the animals received an initial bolus of 0.1 % hyaluronan (1 mg/kg/10 min) or placebo (0.9% saline) followed by a continuous infusion of 0.1% hyaluronan (1 mg/kg/h) or saline during the experiment. We hypothesized that the administration of hyaluronan would reduce the volume of fluid administered (aiming at stroke volume variation <13%) and/or attenuate the inflammatory reaction.Total volumes of intravenous fluids infused were 17.5 ± 11 ml/kg/h vs. 19.0 ± 7 ml/kg/h in intervention and control groups, respectively (p = 0.442). Plasma IL-6 increased to 2450 (1420 - 6890) pg/ml and 3690 (1410 - 11960) pg/ml (18 hours of resuscitation) in the intervention and control groups (NS). The intervention counteracted the increase in proportion of fragmented hyaluronan associated with peritonitis-sepsis (mean peak elution fraction (18 hours of resuscitation) intervention group: 16.8 ± 0.9 vs. control group: 17.9 ± 0.6 (p = 0.031)).In conclusion, hyaluronan did not reduce the volume needed for fluid resuscitation or decrease the inflammatory reaction, even though it counterbalanced the peritonitis induced shift towards increased proportion of fragmented hyaluronan. + Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American College of Sports Medicine. + + + + Barrueta Tenhunen + Annelie + A + + Dept of Surgical Sciences, Division of Anesthesiology and Intensive Care, Uppsala University, Uppsala, Sweden. + + + + van der Heijden + Jaap + J + + Dept of Surgical Sciences, Division of Anesthesiology and Intensive Care, Uppsala University, Uppsala, Sweden. + + + + Dogné + Sophie + S + + Molecular Physiology Research Unit (URPhyM), Namur Research Institute for Life Sciences (NARILIS), University of Namur (Unamur), Belgium. + + + + Flamion + Bruno + B + + Molecular Physiology Research Unit (URPhyM), Namur Research Institute for Life Sciences (NARILIS), University of Namur (Unamur), Belgium. + + + + Weigl + Wojciech + W + + Dept of Surgical Sciences, Division of Anesthesiology and Intensive Care, Uppsala University, Uppsala, Sweden. + + + + Frithiof + Robert + R + + Dept of Surgical Sciences, Division of Anesthesiology and Intensive Care, Uppsala University, Uppsala, Sweden. + + + + Skorup + Paul + P + + Dept of Medical Sciences, Division of Infectious Diseases, Uppsala University, Uppsala, Sweden. + + + + Larsson + Anders + A + + Dept of Medical Sciences, Division of Clinical Chemistry, Uppsala University, Uppsala, Sweden. + + + + Larsson + Anders + A + + Hedenstierna Laboratory, Dept of Surgical Sciences, Uppsala University, Uppsala, Sweden. + + + + Tenhunen + Jyrki + J + + Dept of Surgical Sciences, Division of Anesthesiology and Intensive Care, Uppsala University, Uppsala, Sweden. + + + + eng + + Journal Article + + + 2023 + 02 + 22 + +
+ + United States + Shock + 9421564 + 1073-2322 + + IM + Conflicts of Interest and Source of Funding: The study was financed by grants from the Swedish state under the agreement between the Swedish government and the county councils, the ALF-agreement. The authors declare no conflicts of interest. +
+ + + + 2023 + 2 + 22 + 13 + 44 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809365 + 10.1097/SHK.0000000000002089 + 00024382-990000000-00155 + + +
+ + + 36809360 + + 2023 + 02 + 22 + +
+ + 1432-1904 + + 110 + 2 + + 2023 + Feb + 21 + + + Die Naturwissenschaften + Naturwissenschaften + + Spatially associated or composite life traces from Holocene paleosols and dune sands provide evidence for past biotic interactions. + + 9 + + 10.1007/s00114-023-01837-w + + Biotic interactions (e.g., predation, competition, commensalism) where organisms directly or indirectly influenced one another are of great interest to those studying the history of life but have been difficult to ascertain from fossils. Considering the usual caveats about the temporal resolution of paleontological data, traces and trace fossils in the sedimentary record can record co-occurrences of organisms or their behaviours with relatively high spatial fidelity in a location. Neoichnological studies and studies on recently buried traces, where direct trophic links or other connections between tracemakers are well-known, may help interpret when and where overlapping traces represented true biotic interactions. Examples from Holocene paleosols and other buried continental sediments in Poland include the tight association between mole and earthworm burrows, forming an ichnofabric representing a predator-prey relationship, and that of intersecting insect and root traces demonstrating the impact of trees as both ecosystem engineers and the basis for food chains. Trampling by ungulates, which leaves hoofprints and other sedimentary disturbances, may result in amensal or commensal effects on some biota in the short term and create heterogeneity that later trace-making organisms, such as invertebrate burrowers, can also respond to in turn, though such modified or composite traces may be challenging to interpret. + © 2023. The Author(s). + + + + Hsieh + Shannon + S + http://orcid.org/0000-0002-8074-547X + + Faculty of Geography and Geology, Institute of Geological Sciences, Jagiellonian University, Gronostajowa 3a, 30387, Kraków, Poland. shannonhsieh1@gmail.com. + + + + Uchman + Alfred + A + http://orcid.org/0000-0002-0591-777X + + Faculty of Geography and Geology, Institute of Geological Sciences, Jagiellonian University, Gronostajowa 3a, 30387, Kraków, Poland. + + + + eng + + + Daina 1 + Narodowe Centrum Nauki + + + + grant agreement No 2017/27/L/ST10/03370 + Narodowe Centrum Nauki + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Naturwissenschaften + 0400767 + 0028-1042 + + IM + + Aeolian environment + Ecosystem engineering + Ichnology + Neoichnology + Paleosol + +
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+ + + 36809366 + + 2023 + 02 + 22 + +
+ + 1432-5233 + + + 2023 + Feb + 21 + + + Acta diabetologica + Acta Diabetol + + Diagnostic value of visceral adiposity index in chronic kidney disease: a meta-analysis. + 10.1007/s00592-023-02048-5 + + Several studies have revealed inconsistencies about the predictive properties of visceral adiposity index (VAI) in identifying chronic kidney disease (CKD). To date, it is unclear whether the VAI is a valuable diagnostic tool for CKD. This study intended to evaluate the predictive properties of the VAI in identifying CKD. + The PubMed, Embase, Web of Science, and Cochrane databases were searched for all studies that met our criteria from the earliest available article until November 2022. Articles were assessed for quality using the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2). The heterogeneity was explored with the Cochran Q test and I2 test. Publication bias was detected using Deek's Funnel plot. Review Manager 5.3, Meta-disc 1.4, and STATA 15.0 were used for our study. + Seven studies involving 65,504 participants met our selection criteria and were therefore included in the analysis. Pooled sensitivity (Sen), specificity (Spe), positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR) and area under the curve (AUC) were 0.67 (95%CI: 0.54-0.77), 0.75 (95%CI: 0.65-0.83), 2.7 (95%CI: 1.7-4.2), 0.44 (95%CI: 0.29-0.66), 6 (95%CI:3.00-14.00) and 0.77 (95%CI: 0.74-0.81), respectively. Subgroup analysis indicated that mean age of subjects was the potential source of heterogeneity. The Fagan diagram found that the predictive properties of CKD were 73% when the pretest probability was set to 50%. + The VAI is a valuable agent in predicting CKD and may be helpful in the detection of CKD. More studies are needed for further validation. + © 2023. Springer-Verlag Italia S.r.l., part of Springer Nature. + + + + Fang + Tingting + T + http://orcid.org/0000-0002-6871-2923 + + School of Public Health, Hangzhou Normal University, Hangzhou, 311121, Zhejiang Province, China. + + + + Zhang + Qiuling + Q + + Department of Endocrinology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, 311121, Zhejiang Province, China. + + + + Wang + Yanmei + Y + + Gongli Hospital of Shanghai Pudong New Area, Pudong New Area, Shanghai, 200120, China. + + + + Zha + Hui + H + + Department of Blood Transfusion, Lianshui People's Hospital of Kangda College, Affiliated to Nanjing Medical University, Huai'an, 223400, Jiangsu Province, China. zhahui_ha@163.com. + + + + eng + + + Grant No. PWRl2020-04 + Shanghai Municipal Human Resources Development Program for Outstanding Leaders in Medical Disciplines + + + + + Journal Article + Review + + + 2023 + 02 + 21 + +
+ + Germany + Acta Diabetol + 9200299 + 0940-5429 + + IM + + Chronic kidney disease (CKD) + Meta-analysis + Visceral adiposity index (VAI) + +
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J Clin Invest 116(11):3015–3025. https://doi.org/10.1172/jci28898 + + 10.1172/jci28898 + 17053832 + 1616196 + + + + Schilling JD, Machkovech HM, He L et al (2013) Palmitate and lipopolysaccharide trigger synergistic ceramide production in primary macrophages. J Biol Chem 288(5):2923–2932. https://doi.org/10.1074/jbc.M112.419978 + + 10.1074/jbc.M112.419978 + 23250746 + + + + Zhu Y, Chen YL, Li C et al (2014) The effect of inhibition of endoplasmic reticulum stress on lipolysis in white adipose tissue in a rat model of chronic kidney disease. Acta Pharmacol Sin 35(3):356–362. https://doi.org/10.1038/aps.2013.177 + + 10.1038/aps.2013.177 + 24442147 + 4647896 + + + + Kershaw EE, Flier JS (2004) Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 89(6):2548–2556. https://doi.org/10.1210/jc.2004-0395 + + 10.1210/jc.2004-0395 + 15181022 + + + + Martínez-García C, Izquierdo-Lahuerta A, Vivas Y et al (2015) Renal lipotoxicity-associated inflammation and insulin resistance affects actin cytoskeleton organization in podocytes. PLoS ONE 10(11):e0142291. https://doi.org/10.1371/journal.pone.0142291 + + 10.1371/journal.pone.0142291 + 26545114 + 4636358 + + + + Yi X, Zhu S, Zhu L (2022) Diagnostic accuracy of the visceral adiposity index in patients with metabolic-associated fatty liver disease: a meta-analysis. Lipids Health Dis 21(1):28. https://doi.org/10.1186/s12944-022-01636-8 + + 10.1186/s12944-022-01636-8 + 35249545 + 8898453 + + + + Bijari M, Jangjoo S, Emami N et al (2021) The Accuracy of Visceral Adiposity Index for the Screening of Metabolic Syndrome: A Systematic Review and Meta-Analysis. Int J Endocrinol 2021:6684627. https://doi.org/10.1155/2021/6684627 + + 10.1155/2021/6684627 + 34354748 + 8331306 + + + + Hu L, Huang X, You C et al (2017) Prevalence of overweight, obesity, abdominal obesity and obesity-related risk factors in southern China. PLoS ONE 12(9):e0183934. https://doi.org/10.1371/journal.pone.0183934 + + 10.1371/journal.pone.0183934 + 28910301 + 5598943 + + + + Folsom AR, Kaye SA, Sellers TA et al (1993) Body fat distribution and 5-year risk of death in older women. JAMA 269(4):483–487 + + 10.1001/jama.1993.03500040049035 + 8419667 + + + + Arum O, Boparai RK, Saleh JK et al (2014) Specific suppression of insulin sensitivity in growth hormone receptor gene-disrupted (GHR-KO) mice attenuates phenotypic features of slow aging. Aging Cell 13(6):981–1000. https://doi.org/10.1111/acel.12262 + + 10.1111/acel.12262 + 25244225 + 4326932 + + + + Barzilai N, Huffman DM, Muzumdar RH et al (2012) The critical role of metabolic pathways in aging. Diabetes 61(6):1315–1322. https://doi.org/10.2337/db11-1300 + + 10.2337/db11-1300 + 22618766 + 3357299 + + + + +
+ + + 36809370 + + 2023 + 02 + 22 + +
+ + 1932-6203 + + 18 + 2 + + 2023 + + + PloS one + PLoS One + + Maternal prenatal screening programs that predict trisomy 21, trisomy 18, and neural tube defects in offspring. + + e0281201 + + 10.1371/journal.pone.0281201 + + To determine the efficacy of three different maternal screening programs (first-trimester screening [FTS], individual second-trimester screening [ISTS], and first- and second-trimester combined screening [FSTCS]) in predicting offspring with trisomy 21, trisomy 18, and neural tube defects (NTDs). + A retrospective cohort involving 108,118 pregnant women who received prenatal screening tests during the first (9-13+6 weeks) and second trimester (15-20+6 weeks) in Hangzhou, China from January-December 2019, as follows: FTS, 72,096; ISTS, 36,022; and FSTCS, 67,631 gravidas. + The high and intermediate risk positivity rates for trisomy 21 screening with FSTCS (2.40% and 5.57%) were lower than ISTS (9.02% and 16.14%) and FTS (2.71% and 7.19%); there were statistically significant differences in the positivity rates among the screening programs (all P < 0.05). Detection of trisomy 21 was as follows: ISTS, 68.75%; FSTCS, 63.64%; and FTS, 48.57%. Detection of trisomy 18 was as follows; FTS and FSTCS, 66.67%; and ISTS, 60.00%. There were no statistical differences in the detection rates for trisomy 21 and 18 among the 3 screening programs (all P > 0.05). The positive predictive values (PPVs) for trisomy 21 and 18 were highest with FTS, while the false positive rate (FPR) was lowest with FSTCS. + FSTCS was superior to FTS and ISTS screening and substantially reduced the number of high risk pregnancies for trisomy 21 and 18; however, FSTCS was not significantly different in detecting fetal trisomy 21 and 18 and other confirmed cases with chromosomal abnormalities. + Copyright: © 2023 Chen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Chen + Yiming + Y + https://orcid.org/0000-0003-1532-6049 + + Department of Prenatal Diagnosis and Screening Center, Hangzhou Women's Hospital (Hangzhou Maternity and Child Health Care Hospital), Hangzhou, Zhejiang. + + + Department of the Fourth Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang. + + + + Ning + Wenwen + W + + Department of the Fourth Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang. + + + + Shi + Yezhen + Y + + Data Analysis Department, Zhejiang Biosan Biochemical Technologies Co, Ltd, Hangzhou, Zhejiang, China. + + + + Chen + Yijie + Y + + Department of the Fourth Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang. + + + + Zhang + Wen + W + + Department of Prenatal Diagnosis and Screening Center, Hangzhou Women's Hospital (Hangzhou Maternity and Child Health Care Hospital), Hangzhou, Zhejiang. + + + + Li + Liyao + L + + Department of Prenatal Diagnosis and Screening Center, Hangzhou Women's Hospital (Hangzhou Maternity and Child Health Care Hospital), Hangzhou, Zhejiang. + + + + Wang + Xiaoying + X + + Department of Prenatal Diagnosis and Screening Center, Hangzhou Women's Hospital (Hangzhou Maternity and Child Health Care Hospital), Hangzhou, Zhejiang. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 01 + 14 + + + 2023 + 01 + 18 + + + 2023 + 2 + 22 + 13 + 44 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809370 + 10.1371/journal.pone.0281201 + PONE-D-22-00752 + + +
+ + + 36809374 + + 2023 + 02 + 22 + +
+ + 2163-0763 + + + 2023 + Feb + 21 + + + The journal of trauma and acute care surgery + J Trauma Acute Care Surg + + Incidence of Multiple Organ Failure in Adult Polytrauma Patients: A Systematic Review and Meta-Analysis. + 10.1097/TA.0000000000003923 + + Postinjury multiple organ failure (MOF) is the leading cause of late death in trauma patients. Although MOF was first described 50 years ago, its definition, epidemiology and change in incidence over time are poorly understood. We aimed to describe the incidence of MOF in the context of different MOF definitions, study inclusion criteria, and its change over time. + Cochrane Library, EMBASE, MEDLINE, PubMed and Web of Science databases were searched for articles published between 1977-2022 in English and German. Random effects meta-analysis was performed when applicable. + The search returned 11440 results, of which 842 full-text articles were screened. MOF incidence was reported in 284 studies that used 11 unique inclusion criteria and 40 MOF definitions. 108 studies published from 1992-2018 were included. Weighted MOF incidence by publication year fluctuated from 11%-56% without significant decrease over time. MOF was defined using four scoring systems (Denver, Goris, Marshall, SOFA) and 12 different cut-off values. Overall, 353718 trauma patients were included, of whom 83766 (24%) developed MOF. The weighted incidences of MOF from meta-analysis of 30 eligible studies were: 14.7% (95% CI:12.1%-17.2%) in Denver>3, 12.7% (95% CI:9.3-16.1%) in Denver>3 with blunt injuries only, 28.6% (95% CI:12%-45.1%) in Denver>8, 25.6% (95% CI:10.4%-40.7%) in Goris>4, 29.9% (95% CI:14.9%-45%) in Marshall>5, 20.3% (95% CI:9.4%-31.2%) in Marshall>5 with blunt injuries only, 39.2% (95% CI:33.7%-44.7%) in SOFA>3, 47.3% (95% CI:29.1%-65.5%) in SOFA>4, 55.6% (95% CI:49.1%-62.2%) in SOFA>4 with blunt injuries only, 51.6% (95% CI:45.5%-57.7%) in SOFA>6. + The incidence of postinjury MOF varies largely due to lack of a consensus definition and study population. Until a consensus is reached, further research will be hindered. + Level III, Systematic Review and Meta-Analysis. + Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Association for the Surgery of Trauma. + + + + Ting + Ryan S + RS + 0000-0003-0106-3129 + + + Lewis + Daniel P + DP + 0000-0002-4924-5653 + + + Yang + Kevin X + KX + 0000-0003-1516-0958 + + + Nguyen + Tam Anh + TA + 0000-0002-8401-5466 + + + Sarrami + Pooria + P + 0000-0002-4034-1059 + + + Daniel + Lovana + L + 0000-0003-1241-6567 + + + Hourigan + Samuel + S + + + King + Kate + K + + + Lassen + Christine + C + + + Sarrami + Mahsa + M + + + Ridley + William + W + 0000-0003-1335-7327 + + + Alkhouri + Hatem + H + 0000-0002-5569-704 + + + Dinh + Michael + M + 0000-0002-0086-455 + + + Balogh + Zsolt J + ZJ + 0000-0002-0277-4822 + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + J Trauma Acute Care Surg + 101570622 + 2163-0755 + + IM + Conflict of Interest: The authors declare no conflict of interest. +
+ + + + 2023 + 2 + 22 + 13 + 44 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809374 + 10.1097/TA.0000000000003923 + 01586154-990000000-00276 + + +
+ + + 36809372 + + 2023 + 02 + 22 + +
+ + 1935-2735 + + 17 + 2 + + 2023 + Feb + 21 + + + PLoS neglected tropical diseases + PLoS Negl Trop Dis + + Cost-effectiveness of human T-cell leukemia virus type 1 (HTLV-1) antenatal screening for prevention of mother-to-child transmission. + + e0011129 + + 10.1371/journal.pntd.0011129 + + Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia-lymphoma (ATL) and HTLV-1-associated myelopathy-tropical spastic paraparesis (HAM/TSP) with a poor prognosis. This study aimed to evaluate the cost-effectiveness and health impact of HTLV-1 antenatal screening. + A state-transition model was developed for HTLV-1 antenatal screening and no screening over a lifetime horizon from a healthcare payer perspective. A hypothetical cohort of 30-year-old individuals was targeted. The main outcomes were costs, quality-adjusted life-years (QALYs), life expectancy life-years (LYs), incremental cost-effectiveness ratios (ICERs), HTLV-1 carriers, ATL cases, HAM/TSP cases, ATL-associated deaths, and HAM/TSP-associated deaths. The willingness-to-pay (WTP) threshold was set at US$50,000 per QALY gained. In the base-case analysis, HTLV-1 antenatal screening (US$76.85, 24.94766 QALYs, 24.94813 LYs, ICER; US$40,100 per QALY gained) was cost-effective compared with no screening (US$2.18, 24.94580 QALYs, 24.94807 LYs). Cost-effectiveness was sensitive to the maternal HTLV-1 seropositivity rate, HTLV-1 transmission rate with long-term breastfeeding from HTLV-1 seropositive mothers to children, and the cost of the HTLV-1 antibody test. HTLV-1 antenatal screening was cost-effective when the maternal HTLV-1 seropositivity rate was greater than 0.0022 and the cost of the HTLV-1 antibody test was lower than US$94.8. Probabilistic sensitivity analysis using a second-order Monte-Carlo simulation showed that HTLV-1 antenatal screening was 81.1% cost-effective at a WTP threshold of US$50,000 per QALY gained. For 10,517,942 individuals born between 2011 and 2021, HTLV-1 antenatal screening costs US$785 million, increases19,586 QALYs and 631 LYs, and prevents 125,421 HTLV-1 carriers, 4,405 ATL cases, 3,035 ATL-associated deaths, 67 HAM/TSP cases, and 60 HAM/TSP-associated deaths, compared with no screening over a lifetime. + HTLV-1 antenatal screening is cost-effective and has the potential to reduce ATL and HAM/TSP morbidity and mortality in Japan. The findings strongly support the recommendation for HTLV-1 antenatal screening as a national infection control policy in HTLV-1 high-prevalence countries. + Copyright: © 2023 Akiko Kowada. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Kowada + Akiko + A + https://orcid.org/0000-0001-5200-4300 + + Department of Occupational Health, Kitasato University Graduate School of Medical Sciences, Sagamihara, Kanagawa, Japan. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS Negl Trop Dis + 101291488 + 1935-2727 + + IM + The author has declared that no competing interests exist. +
+ + + + 2022 + 08 + 13 + + + 2023 + 01 + 31 + + + 2023 + 2 + 22 + 13 + 44 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809372 + 10.1371/journal.pntd.0011129 + PNTD-D-22-01040 + + +
+ + + 36809371 + + 2023 + 02 + 22 + +
+ + 0168-6577 + + 39 + 1 + + 2023 + Feb + 21 + + + European journal of population = Revue europeenne de demographie + Eur J Popul + + Double Disadvantage in a Nordic Welfare State: A Demographic Analysis of the Single-Parent Employment Gap in Finland, 1987-2018. + + 2 + + 10.1007/s10680-023-09651-w + + This study demonstrates how an evolving negative educational gradient of single parenthood can interact with changing labour market conditions to shape labour market inequalities between partnered and single parents. We analysed trends in employment rates among Finnish partnered and single mothers and fathers from 1987 to 2018. In the late 1980s' Finland, single mothers' employment was internationally high and on par with that of partnered mothers, and single fathers' employment rate was just below that of partnered fathers. The gaps between single and partnered parents emerged and increased during the 1990s recession, and after the 2008 economic crisis, it widened further. In 2018, the employment rates of single parents were 11-12 percentage points lower than those of partnered parents. We ask how much of this single-parent employment gap could be explained by compositional factors, and the widening educational gradient of single parenthood in particular. We use Chevan and Sutherland's decomposition technique on register data, which allows us to decompose the single-parent employment gap into the composition and rate effects by each category of the background variables. The findings point to an increasing double disadvantage of single parents: the gradually evolving disadvantage in educational backgrounds together with large differences in employment rates between single and partnered parents with low education explain large parts of the widening employment gap. Sociodemographic changes in interaction with changes in the labour market can produce inequalities by family structure in a Nordic society known for its extensive support for combining childcare and employment for all parents. + © 2023. The Author(s). + + + + Härkönen + Juho + J + http://orcid.org/0000-0001-9687-1932 + + European University Institute, Florence, Italy. juho.harkonen@eui.eu. + + + Stockholm University, Stockholm, Sweden. juho.harkonen@eui.eu. + + + + Jalovaara + Marika + M + http://orcid.org/0000-0003-1501-7078 + + Department of Social Research, University of Turku, Turku, Finland. + + + + Lappalainen + Eevi + E + http://orcid.org/0000-0002-7868-3265 + + Department of Social Research, University of Turku, Turku, Finland. + + + + Miettinen + Anneli + A + http://orcid.org/0000-0001-7581-4971 + + Department of Social Research, University of Turku, Turku, Finland. + + + Social Insurance Institution, Helsinki, Finland. + + + + eng + + + 321264 + academy of finland + + + + 320162 + academy of finland + + + + 293103 + academy of finland + + + + 724363 + horizon 2020 framework programme + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Netherlands + Eur J Popul + 8511777 + 0168-6577 + + + Education + Employment + Finland + Inequality + Single fathers + Single mothers + Single parents + +
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H., & Wiik, K. A. (2020). Parenthood and couples’ relative earnings in Norway. European Sociological Review, 36(2), 218–235. https://doi.org/10.1093/esr/jcz062 + + 10.1093/esr/jcz062 + + + + Bernardi, F., & Boertien, D. (2017). Non-intact families and diverging educational destinies: A decomposition analysis for Germany, Italy, the United Kingdom and the United States. Social Science Research, 63(2), 181–191. https://doi.org/10.1016/j.ssresearch.2016.09.004 + + 10.1016/j.ssresearch.2016.09.004 + + + + Brady, D., & Burroway, R. (2012). Targeting, universalism, and single-mother poverty: A multilevel analysis across 18 affluent democracies. Demography, 49(2), 719–746. https://doi.org/10.1007/s13524-012-0094-z + + 10.1007/s13524-012-0094-z + + + + Brady, D., Finnigan, R. M., & Hübgen, S. (2017). Rethinking the risks of poverty: A framework for analyzing risks and penalties. American Journal of Sociology, 123(3), 740–786. https://doi.org/10.1086/693678 + + 10.1086/693678 + + + + Brown, B. 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Cabrera & C. S. Tamis-LeMonda (Eds.), Handbook of father involvement: Multidisciplinary perspectives, 2nd ed., (pp. 338–357). Lawrence Erlbaum Associates. + + + Eggebeen, D. J., Snyder, A. R., & Manning, W. D. (1996). Children in single-father families in demographic perspective. Journal of Family Issues, 17(4), 441–465. https://doi.org/10.1177/019251396017004002 + + 10.1177/019251396017004002 + + + + Esping-Andersen, G. (1999). Social foundations of postindustrial economies. Oxford University Press. + + 10.1093/0198742002.001.0001 + + + + Esser, I., & Olsen, K. M. (2017). Matched on job qualities? Single and coupled parents in European comparison. In R. Nieuwenhuis & L. C. Maldonado (Eds.), The triple bind of single-parent families. Resources, employment and policies to improve well-being (pp. 285–310). Policy Press. + + + Galarneau, D. (2005). Education and income of lone parents. Perspectives on Labour and Income, Issue no 2005112. Statistics Canada. 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+ + + 36809368 + + 2023 + 02 + 22 + +
+ + 1435-1102 + + + 2023 + Feb + 21 + + + Archives of women's mental health + Arch Womens Ment Health + + Maternal postnatal bonding disorder and developmental delays in children: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. + 10.1007/s00737-023-01298-0 + + Although there is some evidence regarding an association between maternal bonding disorder and child development, studies have mainly focused on development during the period of infancy. We aimed to examine the associations between maternal postnatal bonding disorder and developmental delays in children beyond 2 years of age. We analyzed data from 8380 mother-child pairs who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Maternal bonding disorder was defined as Mother-to-Infant Bonding Scale score of ≥5 at 1 month after delivery. The Ages & Stages Questionnaires, Third Edition, which consists of five developmental areas, was used to assess developmental delays in children at 2 and 3.5 years of age. Multiple logistic regression analyses were conducted to examine the associations between postnatal bonding disorder and developmental delays after adjustment for age, education, income, parity, feelings toward pregnancy, postnatal depressive symptoms, child's sex, preterm birth, and birth defects. Bonding disorder was associated with developmental delays in children at 2 and 3.5 years of age: the odds ratios (95% confidence intervals) were 1.55 (1.32-1.83) and 1.60 (1.34-1.90), respectively. Bonding disorder was associated with delay in communication only at 3.5 years of age. Bonding disorder was associated with delay in gross motor, fine motor, and problem solving, but not delay in the personal-social domain, at 2 and 3.5 years of age. In conclusion, maternal bonding disorder 1 month after delivery was associated with an increased risk of developmental delays in children beyond 2 years of age. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature. + + + + Murakami + Keiko + K + http://orcid.org/0000-0003-2103-4106 + + Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8573, Japan. mkeiko-tky@umin.ac.jp. + + + Graduate School of Medicine, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan. mkeiko-tky@umin.ac.jp. + + + + Noda + Aoi + A + + Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8573, Japan. + + + Graduate School of Medicine, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan. + + + Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan. + + + + Ishikuro + Mami + M + + Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8573, Japan. + + + Graduate School of Medicine, Tohoku University, 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University, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan. + + + Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan. + + + + Metoki + Hirohito + H + + Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8573, Japan. + + + Faculty of Medicine, Tohoku Medical and Pharmaceutical University, 1-15-1 Fukumuro, Miyagino-ku, Sendai, Miyagi, 983-8536, Japan. + + + + Kikuya + Masahiro + M + + Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8573, Japan. + + + Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605, Japan. + + + + Saito + Masatoshi + M + + Graduate School of Medicine, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan. + + + Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan. + + + + Sugawara + Junichi + J + + Tohoku Medical Megabank 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PLoS One 14:e0222998 + + 10.1371/journal.pone.0222998 + 31550274 + 6759162 + + + + World Health Organization (2020) Improving early childhood development: WHO guideline. World Health Organization, Geneva + + + Yoshida K, Yamashita H, Conroy S, Marks M, Kumar C (2012) A Japanese version of Mother-to-Infant Bonding Scale: factor structure, longitudinal changes and links with maternal mood during the early postnatal period in Japanese motherse. Arch Womens Ment Health 15:343–352 + + 10.1007/s00737-012-0291-1 + 22733162 + 3443344 + + + + +
+ + + 36809373 + + 2023 + 02 + 22 + +
+ + 1528-1159 + + + 2023 + Feb + 20 + + + Spine + Spine (Phila Pa 1976) + + Hypoalbuminemia as a Predictor of Mortality, Disability, and Readmission in Patients Undergoing Spine Surgery: A Retrospective Analysis. + 10.1097/BRS.0000000000004607 + + Retrospective Cohort Study. + To clarify the association between preoperative albumin status and mortality and morbidity in lumbar spine surgery. + Hypoalbuminemia is a known marker of inflammation and is associated with frailty. Hypoalbuminemia is an identified risk factor for mortality following spine surgery for metastases, yet has not been well studied among spine surgical cohorts outside of metastatic cancer. + We identified patients with preoperative serum albumin lab values who underwent lumbar spine surgery at a US public university health system between 2014 and 2021. Demographic, comorbidity, and mortality data were collected along with pre- and postoperative Oswestry Disability Index (ODI) scores. Any cause readmission within one year of surgery was recorded. Hypoalbuminemia was defined as <3.5 g/dL in serum. We examined Kaplan-Meier survival plots based on serum albumin. Multivariable regression models were used to identify the association between preoperative hypoalbuminemia with mortality, readmission and ODI, while controlling for age, sex, race, ethnicity, procedure and Charlson Comorbidity Index. + Of 2,573 patients, 79 were identified as hypoalbuminemic. Hypoalbuminemic patients had significantly greater adjusted risk of mortality through 1 year (OR 10.2; 95% CI 3.1 - 33.5; P<0.001), and 7 years (HR 4.18; 95% CI 2.29 - 7.65; P<0.001). Hypoalbuminemic patients had ODI scores 13.5 points higher (95%CI 5.7 - 21.4; P<0.001) at baseline. Adjusted readmission rates were not different between groups through 1 year (OR 1.15; 0.5 - 2.62; P=0.75) or through full surveillance (HR 0.82; 95%CI 0.44 - 1.54; P=0.54). + Preoperative hypoalbuminemia was strongly associated with postoperative mortality. Hypoalbuminemic patients did not have demonstrably worse outcomes in their functional disability beyond 6 months. Within the first 6 months following surgery, the hypoalbuminemic group improved at a similar rate to the normoalbuminemic group despite having greater preoperative disability. However, causal inference is limited in this retrospective study. + Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved. + + + + Randell + Zane + Z + + University of Utah, Department of Orthopaedics, Salt Lake City, Utah. + + + + Martin + Brook + B + + University of Utah, Department of Orthopaedics, Salt Lake City, Utah. + + + + Hendrickson + Nathan + N + + University of Minnesota, Department of Orthopedic Surgery, Minneapolis, Minnesota. + + + + Brodke + Darrel + D + + University of Utah, Department of Orthopaedics, Salt Lake City, Utah. + + + + Spiker + Ryan + R + + University of Utah, Department of Orthopaedics, Salt Lake City, Utah. + + + + Lawrence + Brandon + B + + University of Utah, Department of Orthopaedics, Salt Lake City, Utah. + + + + Spina + Nicholas + N + + University of Utah, Department of Orthopaedics, Salt Lake City, Utah. + + + + eng + + Journal Article + + + 2023 + 02 + 20 + +
+ + United States + Spine (Phila Pa 1976) + 7610646 + 0362-2436 + + IM + The author reports no conflicts of interest. +
+ + + + 2022 + 05 + 31 + + + 2023 + 01 + 01 + + + 2023 + 2 + 22 + 13 + 44 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809373 + 10.1097/BRS.0000000000004607 + 00007632-990000000-00241 + + +
+ + + 36809375 + + 2023 + 02 + 22 + +
+ + 1935-2735 + + 17 + 2 + + 2023 + Feb + 21 + + + PLoS neglected tropical diseases + PLoS Negl Trop Dis + + Stool biomarkers as measures of enteric pathogen infection in infants from Addis Ababa informal settlements. + + e0011112 + + 10.1371/journal.pntd.0011112 + + Frequent enteric infections in children may be an important cause of growth faltering; however, we do not fully understand the mechanisms by which pathogen infections and the physiological responses to these infections result in poorer growth. Commonly used protein fecal biomarkers (anti-alpha trypsin, neopterin, and myeloperoxidase) provide broad immunological information on an inflammatory response; however, they do not provide information on non-immune processes (e.g., gut integrity) that may be important indicators of chronic end states such as environmental enteric dysfunction (EED). To explore how additional biomarkers will better inform which physiological pathways (both immune and non-immune) are impacted by pathogen exposure we added to the traditional panel of 3 protein fecal biomarkers 4 novel fecal mRNA transcript biomarkers (sucrase isomaltase, caudal homeobox 1, S100A8, and mucin 12) and analyzed stool samples from infants living in informal settlements in Addis Ababa, Ethiopia. To test how this expanded biomarker panel captures distinct pathogen exposure processes we used two different scoring systems. First, we used a theory-based approach to assign each biomarker to specific physiological attributes based on prior understanding of each biomarker. Second, we used data reduction methods to categorize biomarkers and then assign physiological attributes to those categories. We used linear models to examine the association between the derived biomarker scores (based on mRNA and protein levels) and stool pathogen gene counts to determine pathogen specific effects on gut physiology and immune responses. Inflammation scores were positively associated with Shigella and enteropathogenic E.Coli (EPEC) infection, while gut integrity scores were negatively associated with Shigella, EPEC and, shigatoxigenic E.coli (STEC) infection. Our expanded panel of biomarkers hold promise as tools to measure systemic outcomes of enteric pathogen infection. mRNA biomarkers complement established protein biomarkers by providing important cell-specific physiological and immunological consequences of pathogen carriage that can lead to chronic end states such as EED. + Copyright: © 2023 Espira et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Espira + Leon M + LM + https://orcid.org/0000-0002-1320-3056 + + Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, United States of America. + + + + Lee + Gwenyth O + GO + + Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, United States of America. + + + Rutgers Global Health Institute & Department of Biostatistics and Epidemiology School of Public Health Rutgers, The State University of New Jersey, New Brunswick, New Jersey, United States of America. + + + + Baye + Kaleab + K + + Center for Food Science and Nutrition, College of Natural and Computational Sciences, Addis Ababa University, Addis Ababa, Ethiopia. + + + + Jones + Andrew D + AD + + Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, United States of America. + + + + Love + Nancy G + NG + + Department of Civil and Environmental Engineering, University of Michigan, Ann Arbor, Michigan, United States of America. + + + + Eisenberg + Joseph N S + JNS + + Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, United States of America. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS Negl Trop Dis + 101291488 + 1935-2727 + + IM + The authors have no competing interests to disclose. +
+ + + + 2022 + 07 + 18 + + + 2023 + 01 + 19 + + + 2023 + 2 + 22 + 13 + 44 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809375 + 10.1371/journal.pntd.0011112 + PNTD-D-22-00935 + + +
+ + + 36809376 + + 2023 + 02 + 22 + +
+ + 1432-1904 + + 110 + 2 + + 2023 + Feb + 21 + + + Die Naturwissenschaften + Naturwissenschaften + + Parasites either reduce or increase host vulnerability to fishing: a case study of a parasitic copepod and its salmonid host. + + 10 + + 10.1007/s00114-023-01836-x + + Parasites generally increase host vulnerability to predators via host manipulation for trophic transmission and reduction of host activities. Predators also select prey depending on the parasite infection status. Despite such parasites' roles in prey-predator interactions in wild animals, how parasites affect human hunting probability and resource consumption remains unknown. We examined the effects of the ectoparasitic copepod Salmincola cf. markewitschi on fish vulnerability to angling. We found that infected fish were less vulnerable compared with non-infected fish when the fish body condition was low, which was probably due to reduced foraging activity. On the contrary, infected fish were more vulnerable when the host body condition was high, probably due to the compensation of parasites' negative effects. A Twitter analysis also suggested that people avoided eating fish with parasites and that anglers' satisfaction decreased when captured fish were parasitized. Thus, we should consider how animal hunting is affected by parasites not only for catchability but also for avoiding parasite infection sources in many local regions. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Hasegawa + Ryota + R + http://orcid.org/0000-0002-3563-7031 + + Graduate School of Environmental Science, Hokkaido University, N10W5 Sapporo, Hokkaido, 060-0810, Japan. ryotahase344922@gmail.com. + + + + Koizumi + Itsuro + I + http://orcid.org/0000-0001-8934-8561 + + Graduate School of Environmental Science, Hokkaido University, N10W5 Sapporo, Hokkaido, 060-0810, Japan. + + + Faculty of Environmental Earth Science, Hokkaido University, N10W5 Sapporo, Hokkaido, 060-0810, Japan. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Naturwissenschaften + 0400767 + 0028-1042 + + IM + + Ectoparasite + Host–parasite relationship + Human hunting + Parasite avoidance + Recreational angling + Salmincola + +
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J Fish Biol 73:2228–2237. https://doi.org/10.1111/j.1095-8649.2008.02050.x + + + White CF, Gray MA, Kidd KA, Duffy MS, Lento J, Monk WA (2020) Prevalence and intensity of Salmincola edwardsii in brook trout in northwest New Brunswick, Canada. J Aquat Anim Health 32:11–20. https://doi.org/10.1002/aah.10091 + + + Wilson DS, Coleman K, Clark AB, Biederman L (1993) Shy-bold continuum in pumpkinseed sunfish (Lepomis gibbosus): An ecological study of a psychological trait. J Comp Psychol 107:250–260. https://doi.org/10.1037/0735-7036.107.3.250 + + + Wilson AD, Binder TR, McGrath KP, Cooke SJ, Godin JGJ (2011) Capture technique and fish personality: angling targets timid bluegill sunfish, Lepomis macrochirus. Can J Fish Aquat Sci 68:749–757. https://doi.org/10.1139/f2011-019 + + + Wilson AD, Brownscombe JW, Sullivan B, Jain-Schlaepfer S, Cooke SJ (2015) Does angling technique selectively target fishes based on their behavioural type? PloS ONE 10:e0135848. https://doi.org/10.1371/journal.pone.0135848 + + 10.1371/journal.pone.0135848 + 26284779 + 4540471 + + + + Wood CL, Johnson PT (2015) A world without parasites: exploring the hidden ecology of infection. Front Ecol Environ 13:425–434. https://doi.org/10.1890/140368 + + 10.1890/140368 + 28077932 + 5222570 + + + + +
+ + + 36809382 + + 2023 + 02 + 22 + +
+ + 1559-131X + + 40 + 3 + + 2023 + Feb + 21 + + + Medical oncology (Northwood, London, England) + Med Oncol + + Relationship between glioblastoma multiforme (GBM) and Alzheimer's disease (AD): is there any reporting bias? + + 101 + + 10.1007/s12032-023-01951-9 + + + Ibne Mokbul + Mobin + M + http://orcid.org/0000-0001-9798-2909 + + Dhaka Medical College Hospital, Dhaka, Bangladesh. mobin.dmc@gmail.com. + + + + Siddik + Abu Bakar + AB + + Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA. + + + + eng + + Letter + + + 2023 + 02 + 21 + +
+ + United States + Med Oncol + 9435512 + 1357-0560 + + IM +
+ + + + 2022 + 10 + 24 + + + 2023 + 01 + 15 + + + 2023 + 2 + 22 + 13 + 45 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809382 + 10.1007/s12032-023-01951-9 + 10.1007/s12032-023-01951-9 + + + + Seddighi S, Houck AL, Rowe JB, Pharoah PDP. Evidence of a causal association between cancer and Alzheimer’s disease: a mendelian randomization analysis. Sci Rep. 2019;9(1):13548. https://doi.org/10.1038/s41598-019-49795-6 . (PMID: 31537833 PMCID: PMC6753207). + + 10.1038/s41598-019-49795-6 + 31537833 + 6753207 + + + + Cheray M, Stratoulias V, Joseph B, Grabert K. The rules of engagement: do microglia seal the fate in the inverse relation of glioma and Alzheimer’s disease? Front Cell Neurosci. 2019;20(13):522. https://doi.org/10.3389/fncel.2019.00522 . (PMID: 31824268 PMCID:PMC6879422). + + 10.3389/fncel.2019.00522 + + + + Glioma LS, Disease A. Glioma and Alzheimer’s disease. J Alzheimers Dis Rep. 2018;2(1):213–8. https://doi.org/10.3233/ADR-180084 . (PMID: 30560246 PMCID:PMC6294584). + + 10.3233/ADR-180084 + + + + Sánchez-Valle J, Tejero H, Ibáñez K, Portero JL, Krallinger M, Al-Shahrour F, Tabarés-Seisdedos R, Baudot A, Valencia A. A molecular hypothesis to explain direct and inverse co-morbidities between Alzheimer’s disease, glioblastoma and lung cancer. Sci Rep. 2017;7(1):4474. https://doi.org/10.1038/s41598-017-04400-6 . (PMID:28667284 PMCID:PMC5493619). + + 10.1038/s41598-017-04400-6 + 28667284 + 5493619 + + + + Poole EC, Kepes JJ. Glioblastoma multiforme of the hippocampus in advanced Alzheimer’s disease. Neuropathol Appl Neurobiol. 1991;17(6):509–13. https://doi.org/10.1111/j.1365-2990.1991.tb00753.x . (PMID: 1666175). + + 10.1111/j.1365-2990.1991.tb00753.x + 1666175 + + + + Nelson JS. Alzheimer pathology in elderly patients with glioblastoma multiforme. Arch Pathol Lab Med. 2002;126(12):1515–7. https://doi.org/10.5858/2002-126-1515-APIEPW . (PMID: 12456214). + + 10.5858/2002-126-1515-APIEPW + 12456214 + + + + Cai J, Ye L, Hu Y, Ye Z, Gao L, Wang Y, Sun Q, Tong S, Yang J, Chen Q. Exploring the inverse association of glioblastoma multiforme and Alzheimer’s disease via bioinformatics analysis. Med Oncol. 2022;39(12):182. https://doi.org/10.1007/s12032-022-01786-w . (PMID: 36071287). + + 10.1007/s12032-022-01786-w + 36071287 + + + + Lawrie TA, Gillespie D, Dowswell T, Evans J, Erridge S, Vale L, Kernohan A, Grant R. Long-term neurocognitive and other side effects of radiotherapy, with or without chemotherapy, for glioma. Cochrane Database Syst Rev. 2019;8:013047. https://doi.org/10.1002/14651858.CD013047.pub2 . + + 10.1002/14651858.CD013047.pub2 + + + + Ording AG, Horváth-Puhó E, Veres K, Glymour MM, Rørth M, Sørensen HT, Henderson VW. Cancer and risk of Alzheimer’s disease: small association in a nationwide cohort study. Alzheimers Dement. 2020;16(7):953–64. https://doi.org/10.1002/alz.12090 . (PMID: 32432415 PMCID: PMC7351601). + + 10.1002/alz.12090 + 32432415 + 7351601 + + + + Kim M, Ladomersky E, Mozny A, Kocherginsky M, O’Shea K, Reinstein ZZ, Zhai L, Bell A, Lauing KL, Bollu L, Rabin E, Dixit K, Kumthekar P, Platanias LC, Hou L, Zheng Y, Wu J, Zhang B, Hrachova M, Merrill SA, Mrugala MM, Prabhu VC, Horbinski C, James CD, Yamini B, Ostrom QT, Johnson MO, Reardon DA, Lukas RV, Wainwright DA. Glioblastoma as an age-related neurological disorder in adults. Neurooncol Adv. 2021;3(1):125. https://doi.org/10.1093/noajnl/vdab125 . (PMID: 34647022 PMCID: PMC8500689). + + 10.1093/noajnl/vdab125 + + + + Hedna R, Kovacic H, Pagano A, Peyrot V, Robin M, Devred F, Breuzard G. Tau protein as therapeutic target for cancer? Focus on glioblastoma. Cancers (Basel). 2022;14(21):5386. https://doi.org/10.3390/cancers14215386 . (PMID: 36358803 PMCID: PMC9653627). + + 10.3390/cancers14215386 + 36358803 + + + + Kraus JL. Therapeutic links between Alzheimer’s disease and brain cancer: drug discovery consequences. ChemMedChem. 2013;8(5):689–92. https://doi.org/10.1002/cmdc.201300006 . (PMID: 23444291). + + 10.1002/cmdc.201300006 + 23444291 + + + + Dhenain M, Lam S, Gary C, Herard AS, Koch J, Petit F, Gipchtein P, Sawiak S, Caillierez R, Eddarkaoui S, Colin M, Aujard F, Deslys J-P, Duyckaerts C, Brouillet E, Comoy E, Pifferi F, Picq JL. Iatrogenic transmission of Alzheimer’s disease: evidence based on experimental inoculation of Alzheimer’s brains into a primate. Alzheimer’s Dement. 2020;16:e042957. https://doi.org/10.1002/alz.042957 . + + 10.1002/alz.042957 + + + + Jaunmuktane Z, Banerjee G, Paine S, Parry-Jones A, Rudge P, Grieve J, Toma AK, Farmer SF, Mead S, Houlden H, Werring DJ, Brandner S. Alzheimer’s disease neuropathological change three decades after iatrogenic amyloid-β transmission. Acta Neuropathol. 2021;142(1):211–5. https://doi.org/10.1007/s00401-021-02326-y . (PMID: 34047818 PMCID: PMC8217014). + + 10.1007/s00401-021-02326-y + 34047818 + 8217014 + + + + +
+ + + 36809369 + + 2023 + 02 + 22 + +
+ + 1553-7404 + + 19 + 2 + + 2023 + Feb + 21 + + + PLoS genetics + PLoS Genet + + CLOCK and TIMELESS regulate rhythmic occupancy of the BRAHMA chromatin-remodeling protein at clock gene promoters. + + e1010649 + + 10.1371/journal.pgen.1010649 + + Circadian clock and chromatin-remodeling complexes are tightly intertwined systems that regulate rhythmic gene expression. The circadian clock promotes rhythmic expression, timely recruitment, and/or activation of chromatin remodelers, while chromatin remodelers regulate accessibility of clock transcription factors to the DNA to influence expression of clock genes. We previously reported that the BRAHMA (BRM) chromatin-remodeling complex promotes the repression of circadian gene expression in Drosophila. In this study, we investigated the mechanisms by which the circadian clock feeds back to modulate daily BRM activity. Using chromatin immunoprecipitation, we observed rhythmic BRM binding to clock gene promoters despite constitutive BRM protein expression, suggesting that factors other than protein abundance are responsible for rhythmic BRM occupancy at clock-controlled loci. Since we previously reported that BRM interacts with two key clock proteins, CLOCK (CLK) and TIMELESS (TIM), we examined their effect on BRM occupancy to the period (per) promoter. We observed reduced BRM binding to the DNA in clk null flies, suggesting that CLK is involved in enhancing BRM occupancy to initiate transcriptional repression at the conclusion of the activation phase. Additionally, we observed reduced BRM binding to the per promoter in flies overexpressing TIM, suggesting that TIM promotes BRM removal from DNA. These conclusions are further supported by elevated BRM binding to the per promoter in flies subjected to constant light and experiments in Drosophila tissue culture in which the levels of CLK and TIM are manipulated. In summary, this study provides new insights into the reciprocal regulation between the circadian clock and the BRM chromatin-remodeling complex. + Copyright: © 2023 Tabuloc et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Tabuloc + Christine A + CA + https://orcid.org/0000-0001-5167-314X + + Department of Entomology and Nematology, College of Agricultural and Environmental Sciences, University of California Davis, Davis, California, United States of America. + + + + Cai + Yao D + YD + https://orcid.org/0000-0002-3571-2978 + + Department of Entomology and Nematology, College of Agricultural and Environmental Sciences, University of California Davis, Davis, California, United States of America. + + + + Kwok + Rosanna S + RS + + Department of Entomology and Nematology, College of Agricultural and Environmental Sciences, University of California Davis, Davis, California, United States of America. + + + + Chan + Elizabeth C + EC + + Department of Entomology and Nematology, College of Agricultural and Environmental Sciences, University of California Davis, Davis, California, United States of America. + + + + Hidalgo + Sergio + S + https://orcid.org/0000-0002-2604-156X + + Department of Entomology and Nematology, College of Agricultural and Environmental Sciences, University of California Davis, Davis, California, United States of America. + + + + Chiu + Joanna C + JC + https://orcid.org/0000-0001-7613-8127 + + Department of Entomology and Nematology, College of Agricultural and Environmental Sciences, University of California Davis, Davis, California, United States of America. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS Genet + 101239074 + 1553-7390 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 10 + 17 + + + 2023 + 02 + 02 + + + 2023 + 2 + 22 + 13 + 44 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809369 + 10.1371/journal.pgen.1010649 + PGENETICS-D-22-01191 + + +
+ + + 36809377 + + 2023 + 02 + 22 + +
+ + 1932-6203 + + 18 + 2 + + 2023 + + + PloS one + PLoS One + + Passion fruit plants alter the soil microbial community with continuous cropping and improve plant disease resistance by recruiting beneficial microorganisms. + + e0281854 + + 10.1371/journal.pone.0281854 + + Passion fruit (Passiflora edulis) is widely grown in tropical and subtropical regions, showing high economic and ornamental value. Microorganisms are indicators for the stability and health of the soil ecosystem, which can affect the yield and quality of passion fruit under continuous cropping. High-throughput sequencing and interactive analysis were used to analyse the variation of microbial communities in the noncultivated soil (NCS), cultivated soil (CS), and the rhizosphere soil of purple passion fruit (Passiflora edulis f. edulis ×Passiflora edulis f. flavicarpa, RP) and yellow passion fruit (Passiflora edulis f. flavicarpa, RY). An average of 98,001 high-quality fungal internal transcribed spacer (ITS) sequences, mainly from Ascomycota, Basidiomycota, Mortierellomycota, Mucoromycota and Glomeromycota, as well as an average of 71,299 high-quality bacterial 16S rRNA sequences, mainly from Proteobacteria, Actinobacteria, Acidobacteria, Firmicutes and Chloroflexi, were obtained per sample. It was found that the continuous cropping of passion fruit increased the richness but reduced the diversity of soil fungi, while it dramatically increased the richness and diversity of soil bacteria. In addition, during the continuous cropping, grafting different scions in the same rootstock contributed to the aggregation of differential rhizosphere microbial communities. Among fungal genera, Trichoderma showed higher abundance in RY than in RP and CS, while the opposite was observed in the pathogen Fusarium. Moreover, the co-occurrence network and potential function analyses also showed that the appearance of Trichoderma was related to Fusarium and its contribution to plant metabolism was significantly greater in RY than in RP and CS. In conclusion, the rhizosphere of yellow passion fruit may be beneficial for the enrichment of disease-resistant microbes, such as Trichoderma, which may be an important factor inducing stronger resistance to stem rot. It will help to form a potential strategy for overcoming the pathogen-mediated obstacles in passion fruit and improve its yield and quality. + Copyright: © 2023 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Wang + Ye + Y + + Guizhou Botanical Garden, Guizhou Academy of Sciences, Guiyang, Guizhou, China. + + + Institute of Mountain Resources of Guizhou Province, Guizhou Academy of Sciences, Guiyang, Guizhou, China. + + + + Teng + Yao + Y + + Guizhou Botanical Garden, Guizhou Academy of Sciences, Guiyang, Guizhou, China. + + + Institute of Mountain Resources of Guizhou Province, Guizhou Academy of Sciences, Guiyang, Guizhou, China. + + + + Zhang + Jianli + J + + College of Eco-environmental Engineering, Guizhou Minzu University, Guiyang, Guizhou, China. + + + + Zhang + Zixiong + Z + + Guizhou Botanical Garden, Guizhou Academy of Sciences, Guiyang, Guizhou, China. + + + + Wang + Chen + C + + Guizhou Botanical Garden, Guizhou Academy of Sciences, Guiyang, Guizhou, China. + + + + Wu + Xiukun + X + + Guizhou Botanical Garden, Guizhou Academy of Sciences, Guiyang, Guizhou, China. + + + + Long + Xiuqin + X + https://orcid.org/0000-0002-3167-2542 + + Guizhou Botanical Garden, Guizhou Academy of Sciences, Guiyang, Guizhou, China. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + the authors have declared that no competing interests exist. +
+ + + + 2022 + 03 + 01 + + + 2023 + 02 + 02 + + + 2023 + 2 + 22 + 13 + 44 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809377 + 10.1371/journal.pone.0281854 + PONE-D-22-00927 + + +
+ + + 36809380 + + 2023 + 02 + 22 + +
+ + 1932-6203 + + 18 + 2 + + 2023 + + + PloS one + PLoS One + + Clinical practice guideline recommendation summaries for pediatric oncology health care professionals: A qualitative study. + + e0281890 + + 10.1371/journal.pone.0281890 + + To develop a summary format of clinical practice guideline (CPG) recommendations to improve understandability among health care professionals. + We developed a summary format based on current research and used the "Think Aloud" technique in one-on-one cognitive interviews to iteratively improve it. Interviews of health care professionals from Children's Oncology Group-member, National Cancer Institute Community Oncology Research Program sites were conducted. After every five interviews (a round), responses were reviewed, and changes made to the format until it was well understood and no new, substantive suggestions for revision were raised. We took a directed (deductive) approach to content analysis of the interview notes to identify concerns related to recommendation summary usability, understandability, validity, applicability and visual appeal. + During seven rounds of interviews with 33 health care professionals, we identified important factors that influenced understandability. Participants found understanding weak recommendations more challenging than strong recommendations. Understanding was improved when the term 'conditional' recommendation was used instead of 'weak' recommendation. Participants found a Rationale section to be very helpful but desired more information when a recommendation entailed a practice change. In the final format, the recommendation strength is clearly indicated in the title, highlighted, and defined within a text box. The rationale for the recommendation is in a column on the left, with supporting evidence on the right. In a bulleted list, the Rationale section describes the benefits and harms and additional factors, such as implementation, that were considered by the CPG developers. Each bullet under the supporting evidence section indicates the level of evidence with an explanation and the supporting studies with hyperlinks when applicable. + A summary format to present strong and conditional recommendations was created through an iterative interview process. The format is straightforward, making it easy for organizations and CPG developers to use it to communicate recommendations clearly to intended users. + Copyright: © 2023 Santesso et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Santesso + Nancy + N + + Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada. + + + + Beauchemin + Melissa + M + + Columbia University School of Nursing/Herbert Irving Cancer Center, New York, New York, United States of America. + + + + Robinson + Paula D + PD + + Pediatric Oncology Group of Ontario, Toronto, Ontario, Canada. + + + + Walsh + Alexandra M + AM + + Center for Cancer and Blood Disorders, Phoenix Children's Hospital, University of Arizona, Phoenix, Arizona, United States of America. + + + + Sugalski + Aaron J + AJ + + University of Texas Health Science Center San Antonio, San Antonio, Texas, United States of America. + + + + Lo + Tammy + T + + Department of Research and Evaluation, Kaiser Permanente, Pasadena, California, United States of America. + + + + Dang + Ha + H + + Biostatistics and Data Management, Johnson and Johnson Medical Devices Companies, Irvine, California, United States of America. + + + + Fisher + Brian T + BT + + The Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America. + + + + Grimes + Allison C + AC + + University of Texas Health Science Center San Antonio, San Antonio, Texas, United States of America. + + + + Wrightson + Andrea Rothfus + AR + + Nemours Center for Cancer and Blood Disorders, Wilmington, Delaware, United States of America. + + + + Yu + Lolie C + LC + + LSUHSC/Children's Hospital, New Orleans, Louisiana, United States of America. + + + + Sung + Lillian + L + + Division of Haematology/Oncology, The Hospital for Sick Children and Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada. + + + + Dupuis + L Lee + LL + https://orcid.org/0000-0002-7699-1061 + + Research Institute, The Hospital for Sick Children and Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 02 + 06 + + + 2023 + 02 + 03 + + + 2023 + 2 + 22 + 13 + 44 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809380 + 10.1371/journal.pone.0281890 + PONE-D-22-03727 + + +
+ + + 36809383 + + 2023 + 02 + 22 + +
+ + 1932-6203 + + 18 + 2 + + 2023 + + + PloS one + PLoS One + + Frequency and types of alternative breeding strategies employed by nesting American black ducks in North Carolina. + + e0278905 + + 10.1371/journal.pone.0278905 + + Although most birds are considered to be at least partially monogamous, molecular evidence continues to uncover that many species can have multiple sexual mates. Many species of Waterfowl (Order Anseriformes) consistently deploy alternative breeding strategies, and although cavity nesting species have been well studied, few attempts to understand rates of alternative breeding strategies exist in the Anatini tribe. Here, we assay mitochondrial DNA and thousands of nuclear markers across 20 broods of American black ducks (Anas rubripes; "black duck") that included 19 females and 172 offspring to study population structure as well as types and rates of secondary breeding strategies in coastal North Carolina. First, we report high levels of relatedness among nesting black ducks and offspring and while 17 (of 19) females were of pure black duck descent, three were found to be black duck x mallard (A. platyrhynchos) hybrids. Next, we evaluated for mismatched mitochondrial DNA and paternity identities across each female's clutch to determine types and frequency of alternative or secondary breeding strategies. Although we report that nest parasitism occurred in two nests, 37% (7 of 19) of the sampled nests were multi-paternal as a result of extra-pair copulation. In addition to being part of a mix of strategies used to increase fecundity by successfully breeding females, we posit nest densities providing easier alternative mate access for males also explains high rates of extra-pair copulation among our sampled black ducks. Ultimately, however, while some proportion of females of many species engage in forms of secondary breeding strategies, we conclude that the decision to do so appears to be seasonally flexible for each individual. + Copyright: © 2023 Lavretsky et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Lavretsky + Philip + P + https://orcid.org/0000-0002-5904-8821 + + Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas, United States of America. + + + + Hoyt + Amanda + A + + Department of Entomology and Wildlife Ecology, University of Delaware, Newark, Delaware, United States of America. + + + + Musni + Vergie M + VM + + Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas, United States of America. + + + + Howell + Doug + D + + North Carolina Wildlife Resources Commission, Edenton, North Carolina, United States of America. + + + + Williams + Christopher K + CK + + Department of Entomology and Wildlife Ecology, University of Delaware, Newark, Delaware, United States of America. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 08 + 01 + + + 2022 + 11 + 27 + + + 2023 + 2 + 22 + 13 + 45 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809383 + 10.1371/journal.pone.0278905 + PONE-D-22-21635 + + +
+ + + 36809378 + + 2023 + 02 + 22 + +
+ + 1932-6203 + + 18 + 2 + + 2023 + + + PloS one + PLoS One + + Reaction moments matter when designing lower-extremity robots for tripping recovery. + + e0280158 + + 10.1371/journal.pone.0280158 + + Balance recovery after tripping often requires an active adaptation of foot placement. Thus far, few attempts have been made to actively assist forward foot placement for balance recovery employing wearable devices. This study aims to explore the possibilities of active forward foot placement through two paradigms of actuation: assistive moments exerted with the reaction moments either internal or external to the human body, namely 'joint' moments and 'free' moments, respectively. Both paradigms can be applied to manipulate the motion of segments of the body (e.g., the shank or thigh), but joint actuators also exert opposing reaction moments on neighbouring body segments, altering posture and potentially inhibiting tripping recovery. We therefore hypothesised that a free moment paradigm is more effective in assisting balance recovery following tripping. The simulation software SCONE was used to simulate gait and tripping over various ground-fixed obstacles during the early swing phase. To aid forward foot placement, joint moments and free moments were applied either on the thigh to augment hip flexion or on the shank to augment knee extension. Two realizations of joint moments on the hip were simulated, with the reaction moment applied to either the pelvis or the contralateral thigh. The simulation results show that assisting hip flexion with either actuation paradigm on the thigh can result in full recovery of gait with a margin of stability and leg kinematics closely matching the unperturbed case. However, when assisting knee extension with moments on the shank, free moment effectively assist balance but joint moments with the reaction moment on the thigh do not. For joint moments assisting hip flexion, placement of the reaction moment on the contralateral thigh was more effective in achieving the desired limb dynamics than placing the reaction on the pelvis. Poor choice of placement of reaction moments may therefore have detrimental consequences for balance recovery, and removing them entirely (i.e., free moment) could be a more effective and reliable alternative. These results challenge conventional assumptions and may inform the design and development of a new generation of minimalistic wearable devices to promote balance during gait. + Copyright: © 2023 Jabeen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Jabeen + Saher + S + + Department of Biomechanical Engineering, Delft University of Technology, Delft, The Netherlands. + + + + Baines + Patricia M + PM + https://orcid.org/0000-0002-1841-2551 + + Department of Biomechanical Engineering, Delft University of Technology, Delft, The Netherlands. + + + + Harlaar + Jaap + J + + Department of Biomechanical Engineering, Delft University of Technology, Delft, The Netherlands. + + + Department of Orthopedics, Erasmus University Medical Center, Rotterdam, The Netherlands. + + + + Vallery + Heike + H + + Department of Biomechanical Engineering, Delft University of Technology, Delft, The Netherlands. + + + Department of Rehabilitation Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands. + + + + Berry + Andrew + A + https://orcid.org/0000-0001-7075-8675 + + Department of Biomechanical Engineering, Delft University of Technology, Delft, The Netherlands. + + + Department of Rehabilitation Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 01 + 18 + + + 2022 + 12 + 21 + + + 2023 + 2 + 22 + 13 + 44 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809378 + 10.1371/journal.pone.0280158 + PONE-D-22-01641 + + +
+ + + 36809381 + + 2023 + 02 + 22 + +
+ + 1932-6203 + + 18 + 2 + + 2023 + + + PloS one + PLoS One + + Satisfaction with pandemic management and compliance with public health measures: Evidence from a German household survey on the COVID-19 crisis. + + e0281893 + + 10.1371/journal.pone.0281893 + + We study how satisfaction with government efforts to respond to the COVID-19 crisis affects compliance with pandemic mitigation measures. Using a novel longitudinal household survey for Germany, we overcome the identification and endogeneity challenges involved in estimating individual compliance by using an instrumental variable approach that exploits exogenous variation in two indicators measured before the crisis: political party preferences and the mode of information measured by the frequency of using social media and reading newspapers. We find that a one unit increase in subjective satisfaction (on the 0-10 scale) improves protective behavior by 2-4 percentage points. Satisfaction with the government's COVID-19 management is lower among individuals with right-wing partisan preferences and among individuals who use only social media as an information source. Overall, our results indicate that the effectiveness of uniform policy measures in various domains, such as the health system, social security or taxation, especially during pandemic crises, cannot be fully evaluated without taking individual preferences for collective action into account. + Copyright: © 2023 Jaschke et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Jaschke + Philipp + P + https://orcid.org/0000-0003-3880-6520 + + Institute for Employment Research (IAB), Nuremberg, Germany. + + + + Keita + Sekou + S + https://orcid.org/0000-0002-0235-5951 + + Institute for Employment Research (IAB), Nuremberg, Germany. + + + + Vallizadeh + Ehsan + E + + Institute for Employment Research (IAB), Nuremberg, Germany. + + + University of Bamberg, Bamberg, Germany. + + + + Kühne + Simon + S + https://orcid.org/0000-0002-9257-2297 + + Bielefeld University, Bielefeld, Germany. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 07 + 04 + + + 2023 + 02 + 03 + + + 2023 + 2 + 22 + 13 + 45 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809381 + 10.1371/journal.pone.0281893 + PONE-D-22-18518 + + +
+ + + 36809379 + + 2023 + 02 + 22 + +
+ + 1573-2959 + + 195 + 3 + + 2023 + Feb + 21 + + + Environmental monitoring and assessment + Environ Monit Assess + + Radiological health assessment of infant milk in Erbil Governorate, Iraq. + + 419 + + 10.1007/s10661-023-11010-5 + + In this research, the radioactivity caused by natural radionuclides (40 K, 232Th, and 226Ra) was evaluated in infant milk consumed in Erbil, Iraq. The measurements were performed using an HPGe gamma-ray spectrometer. The variation of activity concentrations in milk samples was (99.56-256.9 Bq kg-1) for 40 K, (BDL-0.53 Bq kg-1) for 232Th, and (0.27-5.59 Bq kg-1) for 226Ra, as determined by the results. The radiological parameters of Eing, Dorg, and ELCR were calculated and compared to international standards. The correlation between computed radiological hazard parameters and natural radionuclides was analyzed statistically using Pearson's correlation. Overall, the results indicate that infant milk consumption in Erbil is radiologically safe and that consumers of these brands of milk are unlikely to be directly exposed to radiological health risks. + © 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG. + + + + Samad + Ahmed I + AI + + Department of Physics, College of Science, Salahaddin University-Erbil, Kurdistan Region, Erbil City, Iraq. ahmed.samad@su.edu.krd. + + + + Ahmed + Ali H + AH + + Department of Physics, College of Science, Salahaddin University-Erbil, Kurdistan Region, Erbil City, Iraq. + + + + Ahmad + Saddon T + ST + + Faculty of Medicine, Koya University, Kurdistan Region - F.R, Koya KOY45, Erbil City, Iraq. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Netherlands + Environ Monit Assess + 8508350 + 0167-6369 + + IM + + Cancer risk + Erbil + HPGe + Milk + Radioactivity + +
+ + + + 2022 + 08 + 17 + + + 2023 + 02 + 06 + + + 2023 + 2 + 22 + 13 + 44 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809379 + 10.1007/s10661-023-11010-5 + 10.1007/s10661-023-11010-5 + + + + Ababneh, Z. Q., Alyassin, A. M., Aljarrah, K. M., & Ababneh, A. M. (2010). Measurement of natural and artificial radioactivity in powdered milk consumed in Jordan and estimates of the corresponding annual effective dose. Radiation Protection Dosimetry, 138(3), 278–283. + + 10.1093/rpd/ncp260 + + + + Abdel-Rahman, M. A. E., El-Mongy, S. A., et al. (2018). Study of some parameters affecting efficiency of HpGe detectors for accurate radionuclides analysis. In The International Conference on Chemical and Environmental Engineering, 9, 371–388. + + + Adam, A. M. A., & Eltayeb, M. A. H. (2012). Multivariate statistical analysis of radioactive variables in two phosphate ores from Sudan. Journal of Environmental Radioactivity, 107, 23–43. + + 10.1016/j.jenvrad.2011.11.021 + + + + Agbalagba, E. O., Agbalagba, H. O., & Avwiri, G. O. (2016). Cost-benefit analysis approach to risk assessment of natural radioactivity in powdered and liquid milk products consumed in Nigeria. Environmental Forensics, 17(3), 191–202. + + 10.1080/15275922.2016.1177753 + + + + Agus, Y. (2017). Radioactivity concentrations of the milk and dairy products. BAUN Institute of Science and Technology, 19(2), 169–176. + + + Al-Zahrani, J. H. (2012). Natural radioactivity and heavy metals in milk consumed in Saudi Arabia and population dose rate estimates. Life Science Journal, 9(2), 651–656. + + + Alamoudi, Z. M. (2013). Assessment of natural radionuclides in powdered milk consumed in Saudi Arabia and estimates of the corresponding annual effective dose. Journal of American Science, 9(6), 267–273. + + + Alrefae, T., Nageswaran, T. N., Al-Failakawi, A., & Al-Shemali, T. (2012). Radioactivity of long lived gamma emitters in milk powder consumed in Kuwait and estimates of annual effective doses. Kuwait Journal of Science and Engineering, 39(1A), 143–158. + + + Bambynek, W. (1987). Uncertainty assignment in radionuclide metrology. Proc. of the First International Summer School La Rabida, Huelva, Spain, M. Garcia-Leon, G. Madurga, editors World Scientific, New-Jersey. + + + Begam, K., Rahman, M. M., Kabir, M. A., Tamim, U., Hossain, S. M., & Begum, A. (2020). Natural radioactivity level of 238 U, 232 Th, and 40 K in baby food and committed annual effective dose assessment in Bangladesh. International Journal of Environmental Monitoring and Analysis, 8(6), 187. + + 10.11648/j.ijema.20200806.12 + + + + Bell, S. J., Judge, S. M., & Regan, P. H. (2012). An investigation of HPGe gamma efficiency calibration software (ANGLE V. 3) for applications in nuclear decommissioning. Applied Radiation and Isotopes, 70(12), 2737–2741. + + 10.1016/j.apradiso.2012.08.007 + + + + Benaissa, K., Seladji, L. N., Kadum, A., & Dahmani, B. (2020). Radionuclide assessment in imported powdered infant milk consumed in algeria and radiation hazard indices. Radiochemistry, 62(5), 673–680. + + 10.1134/S106636222005015X + + + + Desideri, D., Meli, M. A., Roselli, C., Forini, N., Rongoni, A., & Feduzi, L. (2014). Natural radionuclides in Italian diet and their annual intake. Journal of Radioanalytical and Nuclear Chemistry, 299(3), 1461–1467. + + 10.1007/s10967-013-2860-9 + + + + Duong, V. H., Nguyen, T. D., Hegedűs, M., Tóth-Bodrogi, E., & Kovács, T. (2021). Assessment of 232Th, 226Ra, 137Cs, and 40 K concentrations and annual effective dose due to the consumption of Vietnamese fresh milk. Journal of Radioanalytical and Nuclear Chemistry, 328(3), 1399–1404. + + + FAO/WHO. (1995). Report of the twenty-first session of the Joint FAO/WHO Codex Alimentarius Commission, Rome, 3–8 July 1995. In Report of the twenty-first session of the Joint FAO/WHO Codex Alimentarius Commission, Rome, 3–8 July 1995. + + + Giri, S., Singh, G., Jha, V. N., & Tripathi, R. M. (2011). Risk assessment due to ingestion of natural radionuclides and heavy metals in the milk samples: A case study from a proposed uranium mining area, Jharkhand. Environmental Monitoring and Assessment, 175(1), 157–166. + + 10.1007/s10661-010-1502-8 + + + + Groeneveld, R. A., & Meeden, G. (1984). Measuring skewness and kurtosis. Journal of the Royal Statistical Society: Series D (The Statistician), 33(4), 391–399. + + + IAEA. (2011). Safety of Radiation Sources: International Basic Safety Standards--Interim Edition, General Safety Requirements Part 3 No. GSR Part 3 (Interim). Vienna: International Atomic Energy Agency. + + + ICRP. (1996). Age-dependent doses to members of the public from intake of radionuclides: Part 5 compilation of ingestion and inhalation dose coefficients (ICRP Publication 72). IOP Publishing. + + + ICRP. (2007). ICRP publication 103. Ann ICRP, 37(2.4), 2. + + + Jemii, E., & Alharbi, T. (2018). Measurements of natural radioactivity in infant formula and radiological risk assessment. Journal of Radioanalytical and Nuclear Chemistry, 315(2), 157–161. + + 10.1007/s10967-017-5646-7 + + + + Marmuleva, N. I., Barinov, E. Y., & Petukhov, V. L. (2003). Radionuclides accumulation in milk and its products. In Journal de Physique IV (Proceedings), 107, 827–829. + + + Najam, L. A., Tawfiq, N. F., & Kitha, F. H. (2015). Measuring radioactivity level in various types of rice using NaI (Tl) detector. American Journal of Engineering Research, 4(3), 126–132. + + + Poltabtim, W., & Saenboonruang, K. (2019). Assessment of activity concentrations and their associated radiological health risks in commercial infant formulas in Thailand. Chiang Mai Journal of Science, 46, 778–786. + + + Rajeshwari, T., Rajesh, S., Kerur, B. R., Anilkumar, S., Krishnan, N., & Pant, A. D. (2014). Natural radioactivity studies of Bidar soil samples using gamma spectrometry. Journal of Radioanalytical and Nuclear Chemistry, 300(1), 61–65. + + 10.1007/s10967-014-2947-y + + + + Salahel Din, K. (2020). Assessment of natural and artificial radioactivity in infants’ powdered milk and their associated radiological health risks. Journal of Radioanalytical and Nuclear Chemistry, 324(3), 977–981. + + 10.1007/s10967-020-07170-0 + + + + Samad, A. I., Ahmed, A. H., & Ezzulddin, S. K. (2017). Assessment of natural radioactive concentration levels in the oil drilling wells in Erbil Governorate blocks. + + + Sarker, M. S. D., Rahman, R., Siraz, M. M. M., Khandaker, M. U., & Yeasmin, S. (2021). The presence of primordial radionuclides in powdered milk and estimation of the concomitant ingestion dose. Radiation Physics and Chemistry, 188, 109597. + + 10.1016/j.radphyschem.2021.109597 + + + + Taskin, H., Karavus, M., Ay, P., Topuzoglu, A., Hidiroglu, S., & Karahan, G. (2009). Radionuclide concentrations in soil and lifetime cancer risk due to gamma radioactivity in Kirklareli, Turkey. Journal of Environmental Radioactivity, 100(1), 49–53. + + 10.1016/j.jenvrad.2008.10.012 + + + + Tawalbeh, A., Abumurad, K. M., Abu-Nameh, E. S. M., & Qaisi, A. M. (2020). Measurement of natural radionuclides levels and their aannual effective doses in different types of powdered milk consumed by infants in Jordan. Jordan Journal of Pharmaceutical Sciences, 13(1). + + + Tawalbeh, A., Abumurad, K. M., Samat, S. B., Yasir, M. S., & Others. (2011). A study of natural radionuclide activities and radiation hazard index in some grains consumed in Jordan. Malaysian Journal of Analytical Sciences, 15(1), 61–69. + + + UNSCEAR, S. (2000). Effects of ionizing radiation. United Nations, New York, 453–487. + + + Uwatse, O. B., Olatunji, M. A., Khandaker, M. U., Amin, Y. M., Bradley, D. A., Alkhorayef, M., & Alzimami, K. (2015). Measurement of natural and artificial radioactivity in infant powdered milk and estimation of the corresponding annual effective dose. Environmental Engineering Science, 32(10), 838–846. + + 10.1089/ees.2015.0114 + + + + WHO. (1993). Guideline for drinking water quality; measurement of natural and artificial radioactivity in powder milk corresponding Annual Effective Dose Radiation Protection Vol. 1 Recommendations Geneva. + + + +
+ + + 36809385 + + 2023 + 02 + 22 + +
+ + 1573-6822 + + + 2023 + Feb + 21 + + + Cell biology and toxicology + Cell Biol Toxicol + + EGR1 is crucial for the chlorogenic acid-provided promotion on liver regeneration and repair after APAP-induced liver injury. + 10.1007/s10565-023-09795-9 + + Improper use of acetaminophen (APAP) will induce acute liver failure. This study is designed to investigate whether early growth response-1 (EGR1) participated in the promotion on liver repair and regeneration after APAP-induced hepatotoxicity provided by natural compound chlorogenic acid (CGA). APAP induced the nuclear accumulation of EGR1 in hepatocytes regulated by extracellular-regulated protein kinase (ERK)1/2. In Egr1 knockout (KO) mice, the liver damage caused by APAP (300 mg/kg) was more severe than in wild-type (WT) mice. Results of chromatin immunoprecipitation and sequencing (ChIP-Seq) manifested that EGR1 could bind to the promoter region in Becn1, Ccnd1, and Sqstm1 (p62) or the catalytic/modify subunit of glutamate-cysteine ligase (Gclc/Gclm). Autophagy formation and APAP-cysteine adduct (APAP-CYS) clearance were decreased in Egr1 KO mice administered with APAP. The EGR1 deletion reduced hepatic cyclin D1 expression at 6, 12, or 18 h post APAP administration. Meanwhile, the EGR1 deletion also decreased hepatic p62, Gclc and Gclm expression, GCL enzymatic activity, and glutathione (GSH) content and decreased nuclear factor erythroid 2-related factor 2 (Nrf2) activation and thus aggravated oxidative liver injury induced by APAP. CGA increased EGR1 nuclear accumulation; enhanced hepatic Ccnd1, p62, Gclc, and Gclm expression; and accelerated the liver regeneration and repair in APAP-intoxicated mice. In conclusion, EGR1 deficiency aggravated liver injury and obviously delayed liver regeneration post APAP-induced hepatotoxicity through inhibiting autophagy, enhancing liver oxidative injury, and retarding cell cycle progression, but CGA promoted the liver regeneration and repair in APAP-intoxicated mice via inducing EGR1 transcriptional activation. + © 2023. The Author(s), under exclusive licence to Springer Nature B.V. + + + + Wei + Mengjuan + M + + The MOE Key Laboratory for Standardization of Chinese Medicines, Shanghai Key Laboratory of Compound Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. + + + + Gu + Xinnan + X + + The MOE Key Laboratory for Standardization of Chinese Medicines, Shanghai Key Laboratory of Compound Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. + + + + Li + Han + H + + Center for Drug Safety Evaluation and Research, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. + + + + Zheng + Zhiyong + Z + + The MOE Key Laboratory for Standardization of Chinese Medicines, Shanghai Key Laboratory of Compound Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. + + + + Qiu + Zhimiao + Z + + The MOE Key Laboratory for Standardization of Chinese Medicines, Shanghai Key Laboratory of Compound Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. + + + + Sheng + Yuchen + Y + + Center for Drug Safety Evaluation and Research, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. + + + + Lu + Bin + B + + The MOE Key Laboratory for Standardization of Chinese Medicines, Shanghai Key Laboratory of Compound Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. + + + + Wang + Zhengtao + Z + + The MOE Key Laboratory for Standardization of Chinese Medicines, Shanghai Key Laboratory of Compound Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. + + + + Ji + Lili + L + + The MOE Key Laboratory for Standardization of Chinese Medicines, Shanghai Key Laboratory of Compound Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. lichenyue1307@126.com. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Netherlands + Cell Biol Toxicol + 8506639 + 0742-2091 + + IM + + APAP + CGA + EGR1 + Liver injury + Liver regeneration + +
+ + + + 2022 + 11 + 17 + + + 2023 + 01 + 31 + + + 2023 + 2 + 22 + 13 + 45 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809385 + 10.1007/s10565-023-09795-9 + 10.1007/s10565-023-09795-9 + + + + Apte U, Singh S, Zeng G, Cieply B, Virji MA, Wu T, et al. Beta-catenin activation promotes liver regeneration after acetaminophen-induced injury. Am J Pathol. 2009;175(3):1056–65. + + 19679878 + 2731124 + 10.2353/ajpath.2009.080976 + + + + Bai QY, Yan HY, Sheng YC, Jin Y, Shi L, Ji LL, et al. Long-term acetaminophen treatment induced liver fibrosis in mice and the involvement of Egr-1. Toxicology. 2017;382:47–58. + + 28286204 + 10.1016/j.tox.2017.03.008 + + + + Bhushan B, Apte U. Liver regeneration after acetaminophen hepatotoxicity: mechanisms and therapeutic opportunities. Am J Pathol. 2019;189(4):719–29. + + 30653954 + 6446224 + 10.1016/j.ajpath.2018.12.006 + + + + Bhushan B, Borude P, Edwards G, Walesky C, Cleveland J, Li F, et al. Role of bile acids in liver injury and regeneration following acetaminophen overdose. Am J Pathol. 2013;183(5):1518–26. + + 24007882 + 3814573 + 10.1016/j.ajpath.2013.07.012 + + + + Bhushan B, Walesky C, Manley M, Gallagher T, Borude P, Edwards G, et al. Pro-regenerative signaling after acetaminophen-induced acute liver injury in mice identified using a novel incremental dose model. Am J Pathol. 2014;184(11):3013–25. + + 25193591 + 4215032 + 10.1016/j.ajpath.2014.07.019 + + + + Bhushan B, Chavan H, Borude P, Xie YC, Du K, Mcgill MR, et al. Dual role of epidermal growth factor receptor in liver injury and regeneration after acetaminophen overdose in mice. Toxicol Sci. 2017;155(2):363–78. + + 28123000 + 10.1093/toxsci/kfw213 + + + + Bunchorntavakul CM, Reddy KR. Acetaminophen-related hepatotoxicity. Clin Liver Dis. 2013;17(4):587–607. + + 24099020 + 10.1016/j.cld.2013.07.005 + + + + Bunchorntavakul CM, Reddy KR. Acetaminophen (APAP or N-acetyl-p-aminophenol) and acute liver failure. 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+ + + 36809367 + + 2023 + 02 + 22 + +
+ + 2795-4552 + + + 2023 + Feb + 21 + + + ARP rheumatology + ARP Rheumatol + + Impact of biologic therapies on risk of adverse cardiovascular events in patients with Ankylosing Spondylitis or Psoriatic Arthritis: A systematic literature review. + + + + + Recent evidence highlights increased mortality and morbidity due to cardiovascular disease (CVD), especially within the two major forms of Spondyloarthropathies (SpAs), Ankylosing Spondylitis (AS) and Psoriatic Arthritis (PsA). Healthcare professionals and patients in these populations should be alerted regarding the high risk of cardiovascular (CV) events and thus, customize the treatment strategy accordingly. + This systematic literature review aimed to determine the effects of biological therapies on serious CV events in AS and PsA. + Screening for the study was carried out using PubMed and Scopus databases from the database's inception to the 17th of July 2021. The literature search strategy for this review is based on the Population, Intervention, Comparator, Outcomes (PICOs) framework. Randomized controlled trials (RCTs) of biologic therapies for the treatment of AS and/or PsA were included. The primary outcome measure was the number of serious CV events reported during the placebo-controlled phase. + 4,422 articles were generated from keywords, eligibility criteria, and databases. Following the screening, we retained 13 studies for analysis: 3 in AS and 10 in PsA. Meta-analysis of results was not feasible due to the small number of the identified studies, the heterogeneity of the biologic treatment and the included populations, as well as the infrequently reported requested endpoint. According to our review, biologic treatments are safe options as for CV risk in patients with PsA or AS. + Further and more extensive trials in AS/PsA patients at high risk of CV events are needed before firm conclusions can be drawn. + + + + Magiouf + Konstantina Samira + KS + + National and Kapodistrian University of Athens, Greece. + + + + Fragiadaki + Kalliopi + K + + National and Kapodistrian University of Athens School of Health Sciences, Athens, Greece. + + + + Charpidou + Adrianni + A + + "Sotiria" Hospital for Diseases of the Chest, National and Kapodistrian University of Athens, Athens, Greece. + + + + Syrigos + Alexandros + A + + "Sotiria" Hospital for Diseases of the Chest, National and Kapodistrian University of Athens, Athens, Greece. + + + + Kotteas + Elias + E + + "Sotiria" Hospital for Diseases of the Chest, National and Kapodistrian University of Athens, Athens, Greece. + + + + Kourlaba + Georgia + G + + University of Peloponnese, Tripoli, Greece. + + + + eng + + Journal Article + + Impact of biologic therapies on risk of adverse cardiovascular events in patients with Ankylosing Spondylitis or Psoriatic Arthritis: A systematic literature review. + + 2023 + 02 + 21 + +
+ + Portugal + ARP Rheumatol + 9918402287906676 + 2795-4552 + + IM + + Ankylosing Spondylitis + Psoriatic Arthritis + Spondyloarthropathies + serious cardiovascular events biologic therapies. + +
+ + + + 2023 + 2 + 22 + 13 + 44 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809367 + AR220236 + + +
+ + + 36809384 + + 2023 + 02 + 22 + +
+ + 1932-6203 + + 18 + 2 + + 2023 + + + PloS one + PLoS One + + Towards an explainable clinical decision support system for large-for-gestational-age births. + + e0281821 + + 10.1371/journal.pone.0281821 + + A myriad of maternal and neonatal complications can result from delivery of a large-for-gestational-age (LGA) infant. LGA birth rates have increased in many countries since the late 20th century, partially due to a rise in maternal body mass index, which is associated with LGA risk. The objective of the current study was to develop LGA prediction models for women with overweight and obesity for the purpose of clinical decision support in a clinical setting. Maternal characteristics, serum biomarkers and fetal anatomy scan measurements for 465 pregnant women with overweight and obesity before and at approximately 21 weeks gestation were obtained from the PEARS (Pregnancy Exercise and Nutrition with smart phone application support) study data. Random forest, support vector machine, adaptive boosting and extreme gradient boosting algorithms were applied with synthetic minority over-sampling technique to develop probabilistic prediction models. Two models were developed for use in different settings: a clinical setting for white women (AUC-ROC of 0.75); and a clinical setting for women of all ethnicity and regions (AUC-ROC of 0.57). Maternal age, mid upper arm circumference, white cell count at the first antenatal visit, fetal biometry and gestational age at fetal anatomy scan were found to be important predictors of LGA. Pobal HP deprivation index and fetal biometry centiles, which are population-specific, are also important. Moreover, we explained our models with Local Interpretable Model-agnostic Explanations (LIME) to improve explainability, which was proven effective by case studies. Our explainable models can effectively predict the probability of an LGA birth for women with overweight and obesity, and are anticipated to be useful to support clinical decision-making and for the development of early pregnancy intervention strategies to reduce pregnancy complications related to LGA. + Copyright: © 2023 Du et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Du + Yuhan + Y + + UCD Perinatal Research Centre, School of Computer Science, University College Dublin, Dublin, Ireland. + + + + Rafferty + Anthony R + AR + + UCD Perinatal Research Centre, School of Medicine, University College Dublin, National Maternity Hospital, Dublin, Ireland. + + + + McAuliffe + Fionnuala M + FM + + UCD Perinatal Research Centre, School of Medicine, University College Dublin, National Maternity Hospital, Dublin, Ireland. + + + + Mehegan + John + J + + UCD School of Public Health, Physiotherapy and Sports Science, University College Dublin, Dublin, Ireland. + + + + Mooney + Catherine + C + https://orcid.org/0000-0002-7696-1364 + + UCD Perinatal Research Centre, School of Computer Science, University College Dublin, Dublin, Ireland. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2021 + 11 + 30 + + + 2023 + 01 + 31 + + + 2023 + 2 + 22 + 13 + 45 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809384 + 10.1371/journal.pone.0281821 + PONE-D-21-37959 + + +
+ + + 36809390 + + 2023 + 02 + 22 + +
+ + 1875-8312 + + + 2023 + Feb + 21 + + + The international journal of cardiovascular imaging + Int J Cardiovasc Imaging + + Aortic root rotational position associates with aortic valvar incompetence and aortic dilation after arterial switch operation for transposition of the great arteries. + 10.1007/s10554-023-02794-1 + + Aortic dilation and valvar regurgitation can develop in transposition of the great arteries (TGA) after the arterial switch operation (ASO). Variation in aortic root rotational position affects flow dynamics in patients without congenital heart disease. The aim of this study was to assess neo-aortic root (neo-AoR) rotational position and its association with neo-AoR dilation, ascending aorta (AAo) dilation, and neo-aortic valvar regurgitation in TGA following ASO. + Patients with TGA repaired by ASO who underwent cardiac magnetic resonance (CMR) were reviewed. Neo-AoR rotational angle, neo-AoR and AAo dimensions indexed (to height), indexed left ventricular end diastolic volume (LVEDVI), and neo-aortic valvar regurgitant fraction (RF) were obtained from CMR. + Among 36 patients, the median age at CMR was 17.1 years (12.3, 21.9). Neo-AoR rotational angle (range - 52 to + 78°) was clockwise ( ≥ + 15°) in 50%, counterclockwise (<-9°) in 25%, and central (-9 to + 14°) in 25% of patients. A quadratic term for neo-AoR rotational angle, indicating increasing extremes of counterclockwise and clockwise angles, was associated with neo-AoR dilation (R2 = 0.132, p = 0.03), AAo dilation (R2 = 0.160, p = 0.016), and LVEDVI (R2 = 0.20, p = 0.007). These associations remained statistically significant on multivariable analyses. Rotational angle was negatively associated with neo-aortic valvar RF on univariable (p < 0.05) and multivariable analyses (p < 0.02). Rotational angle was associated with smaller bilateral branch pulmonary arteries (p = 0.02). + In patients with TGA after ASO, neo-AoR rotational position likely affects valvar function and hemodynamics, leading to a risk of neo-AoR and AAo dilation, aortic valvar incompetence, increasing left ventricular size, and smaller branch pulmonary arteries. + © 2023. The Author(s), under exclusive licence to Springer Nature B.V. + + + + Tseng + Stephanie Y + SY + + The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. stephanie.tseng@nationwidechildrens.org. + + + The Heart Center, Nationwide Children's Hospital, Columbus, OH, USA. stephanie.tseng@nationwidechildrens.org. + + + + Tretter + Justin T + JT + + The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. + + + Department of Pediatric Cardiology, The Heart, Vascular, and Thoracic Institute, Cleveland Clinic Children's, Cleveland Clinic, Cleveland, OH, USA. + + + + Gao + Zhiqian + Z + + The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. + + + + Ollberding + Nicholas J + NJ + + Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. + + + Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. + + + + Lang + Sean M + SM + + The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. + + + Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Int J Cardiovasc Imaging + 100969716 + 1569-5794 + + IM + + Aortic regurgitation + Aortic root dilation + Arterial switch operation + Transposition of the great arteries + +
+ + + + 2022 + 07 + 06 + + + 2023 + 01 + 02 + + + 2023 + 2 + 22 + 13 + 45 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809390 + 10.1007/s10554-023-02794-1 + 10.1007/s10554-023-02794-1 + + + + Williams WG, McCrindle BW, Ashburn DA, Jonas RA, Mavroudis C, Blackstone EH, and Congenital Heart Surgeon’s S (2003) Outcomes of 829 neonates with complete transposition of the great arteries 12–17 years after repair. Eur J Cardiothorac Surg 24(1);1–9; discussion 9–10. https://doi.org/10.1016/s1010-7940(03)00264-1 + + + Fricke TA, d’Udekem Y, Richardson M, Thuys C, Dronavalli M, Ramsay JM, Wheaton G, Grigg LE, Brizard CP, Konstantinov IE (2012) Outcomes of the arterial switch operation for transposition of the great arteries: 25 years of experience. 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Eur J Radiol 89:60–66. https://doi.org/10.1016/j.ejrad.2017.01.009 + + 10.1016/j.ejrad.2017.01.009 + 28267550 + + + + Powell SK, Almeneisi H, Alsaied T, Shikany A, Riley L, Miller E, Belonis A, Weaver KN, Brown N, Mori S, Tretter JT (2021) Rotational position of the aortic Root is Associated with increased aortic dimensions in Marfan and Loeys-Dietz Syndrome. https://doi.org/10.1007/s00246-021-02594-1 . Pediatr Cardiol + + + Cohen MS, Eidem BW, Cetta F, Fogel MA, Frommelt PC, Ganame J, Han BK, Kimball TR, Johnson RK, Mertens L, Paridon SM, Powell AJ, Lopez L (2016) Multimodality Imaging Guidelines of patients with transposition of the great arteries: a report from the American Society of Echocardiography developed in collaboration with the Society for Cardiovascular magnetic resonance and the Society of Cardiovascular computed Tomography. J Am Soc Echocardiogr 29(7):571–621. https://doi.org/10.1016/j.echo.2016.04.002 + + 10.1016/j.echo.2016.04.002 + 27372954 + + + + Tretter JT, Mori S (2019) Two-dimensional imaging of a Complex Three-Dimensional structure: measurements of aortic Root Dimensions. J Am Soc Echocardiogr 32(6):792–794. https://doi.org/10.1016/j.echo.2019.02.001 + + 10.1016/j.echo.2019.02.001 + 30926407 + + + + Zafar MA, Li Y, Rizzo JA, Charilaou P, Saeyeldin A, Velasquez CA, Mansour AM, Bin Mahmood SU, Ma WG, Brownstein AJ, Tranquilli M, Dumfarth J, Theodoropoulos P, Thombre K, Tanweer M, Erben Y, Peterss S, Ziganshin BA, Elefteriades JA (2018) Height alone, rather than body surface area, suffices for risk estimation in ascending aortic aneurysm. J Thorac Cardiovasc Surg 155(5):1938–1950. https://doi.org/10.1016/j.jtcvs.2017.10.140 + + 10.1016/j.jtcvs.2017.10.140 + 29395211 + + + + van der Bom T, van der Palen RL, Bouma BJ, van Veldhuisen SL, Vliegen HW, Konings TC, Zwinderman AH, Blom NA, Koolbergen DR, Hazekamp MG, Mulder BJ (2014) Persistent neo-aortic growth during adulthood in patients after an arterial switch operation. Heart 100(17):1360–1365. https://doi.org/10.1136/heartjnl-2014-305702 + + 10.1136/heartjnl-2014-305702 + 24837983 + + + + Sundstrom E, Jonnagiri R, Gutmark-Little I, Gutmark E, Critser P, Taylor MD, Tretter JT (2020) Effects of normal variation in the Rotational position of the aortic Root on Hemodynamics and tissue biomechanics of the thoracic aorta. Cardiovasc Eng Technol 11(1):47–58. https://doi.org/10.1007/s13239-019-00441-2 + + 10.1007/s13239-019-00441-2 + 31701357 + + + + Toh H, Mori S, Tretter JT, Izawa Y, Shimoyama S, Suzuki M, Takahashi Y, Tsuda D, Toba T, Fujiwara S, Hirata KI, Anderson RH (2020) Living anatomy of the ventricular myocardial crescents supporting the coronary aortic sinuses. Semin Thorac Cardiovasc Surg 32(2):230–241. https://doi.org/10.1053/j.semtcvs.2020.01.001 + + 10.1053/j.semtcvs.2020.01.001 + 31954834 + + + + Marino BS, Wernovsky G, McElhinney DB, Jawad A, Kreb DL, Mantel SF, van der Woerd WL, Robbers-Visser D, Novello R, Gaynor JW, Spray TL, Cohen MS (2006) Neo-aortic valvar function after the arterial switch. Cardiol Young 16(5):481–489. https://doi.org/10.1017/S1047951106000953 + + 10.1017/S1047951106000953 + 16984700 + + + + Grotenhuis HB, Cifra B, Mertens LL, Riessenkampff E, Manlhiot C, Seed M, Yoo SJ, Grosse-Wortmann L (2019) Left ventricular remodelling in long-term survivors after the arterial switch operation for transposition of the great arteries. Eur Heart J Cardiovasc Imaging 20(1):101–107. https://doi.org/10.1093/ehjci/jey072 + + 10.1093/ehjci/jey072 + 29800129 + + + + Kuebler JD, Chen MH, Alexander ME, Rhodes J (2016) Exercise Performance in Patients with D-Loop Transposition of the great arteries after arterial switch operation: Long-Term Outcomes and Longitudinal Assessment. Pediatr Cardiol 37(2):283–289. https://doi.org/10.1007/s00246-015-1275-5 + + 10.1007/s00246-015-1275-5 + 26439943 + + + + Raju V, Burkhart HM, Durham LA 3, Eidem BW, Phillips SD, Li Z, Schaff HV, Dearani JA (2013) Reoperation after arterial switch: a 27-year experience. Ann Thorac Surg 95(6);2105-12; discussion 2112-3. https://doi.org/10.1016/j.athoracsur.2013.02.040 + + + +
+ + + 36809387 + + 2023 + 02 + 22 + +
+ + 1430-2772 + + + 2023 + Feb + 21 + + + Psychological research + Psychol Res + + Octave illusion: stimulation frequencies can modulate perception. + 10.1007/s00426-023-01805-z + + The octave illusion (Deutsch, 1974) is a well-known auditory illusion elicited by presenting a dichotic sequence of two tones separated by an octave during which the high and low tones alternate between both ears. This illusion engages an important mechanism of auditory perception, which is pitch perception. Previous studies used central frequencies of the useful musical spectrum to elicit the illusion. However, these studies did not cover part of that spectrum where musical pitch perception decreases (below 200 and above 1600 Hz). The present study aimed to investigate how the relative frequency distribution of percepts changes across a greater proportion of the musical scale to better understand the influence of pitch on illusion perception. Participants were presented with 7 pairs of frequencies from 40-80 Hz to 2000-4000 Hz and had to select a choice (octave, simple, complex) corresponding to their perception. When using pairs of stimuli towards the upper and lower boundaries of the selected range: (1) distributions of percepts significantly differ from the classic 400-800 Hz, (2) the octave percept was reported less frequently, particularly at very low frequencies. Results from this study revealed that the illusion perception differs significantly at the low and high limits of the musical spectrum where reduced accuracy of pitch perception is known to occur. These results support past studies who investigated pitch perception. Furthermore, these results support the model proposed by Deutsch where pitch perception is one of the central frameworks of illusion perception. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Whittom + Alexis + A + + Faculty of Medicine, Université Laval, Quebec City, Canada. + + + CERVO Brain Research Center, Quebec City, Canada. + + + + Couture + Florence + F + + Faculty of Medicine, Université Laval, Quebec City, Canada. + + + + Chauvette + Loonan + L + + Faculty of Medicine, Université Laval, Quebec City, Canada. + + + CERVO Brain Research Center, Quebec City, Canada. + + + + Sharp + Andréanne + A + http://orcid.org/0000-0001-8483-6961 + + Faculty of Medicine, Université Laval, Quebec City, Canada. andreanne.sharp@fmed.ulaval.ca. + + + CERVO Brain Research Center, Quebec City, Canada. andreanne.sharp@fmed.ulaval.ca. + + + + eng + + + 102099 + CERVO Brain Research Center + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Psychol Res + 0435062 + 0340-0727 + + IM +
+ + + + 2022 + 05 + 24 + + + 2023 + 02 + 09 + + + 2023 + 2 + 22 + 13 + 45 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809387 + 10.1007/s00426-023-01805-z + 10.1007/s00426-023-01805-z + + + + Attneave, F., & Olson, R. K. (1971). Pitch as a medium: a new approach to psychophysical scaling. The American journal of psychology, 147–166. + + + Besson, M., Schön, D., Moreno, S., Santos, A., & Magne, C. (2007). Influence of musical expertise and musical training on pitch processing in music and language. Restorative Neurology and Neuroscience, 25(3–4), 399–410. + + 17943015 + + + + Biasutti, M. (1997). Sharp low-and high-frequency limits on musical chord recognition. Hearing Research, 105(1–2), 77–84. https://doi.org/10.1016/S0378-5955(96)00205-5 + + 10.1016/S0378-5955(96)00205-5 + 9083806 + + + + Brancucci, A., Padulo, C., & Tommasi, L. (2009). “Octave illusion” or “Deutsch’s illusion”? Psychological Research Psychologische Forschung, 73(3), 303–307. https://doi.org/10.1007/s00426-008-0153-7 + + 10.1007/s00426-008-0153-7 + 18504606 + + + + Brancucci, A., Padulo, C., Franciotti, R., Tommasi, L., & Della Penna, S. (2018). Involvement of ordinary what and where auditory cortical areas during illusory perception. Brain Structure and Function, 223(2), 965–979. https://doi.org/10.1007/s00429-017-1538-4 + + 10.1007/s00429-017-1538-4 + 29071383 + + + + Bregman, A. S. (1994). Auditory scene analysis: The perceptual organization of sound. MIT Press. https://doi.org/10.7551/mitpress/1486.001.0001 + + 10.7551/mitpress/1486.001.0001 + + + + Bregman, A. S., & Steiger, H. (1980). Auditory streaming and vertical localization: Interdependence of “what” and “where” decisions in audition. Perception & Psychophysics, 28(6), 539–546. https://doi.org/10.3758/BF03198822 + + 10.3758/BF03198822 + + + + Brennan, D., & Stevens, C. (2002). Specialist musical training and the octave illusion: analytical listening and veridical perception by pipe organists. Acta Psychologica, 109(3), 301–314. https://doi.org/10.1016/S0001-6918(01)00063-4 + + 10.1016/S0001-6918(01)00063-4 + 11881905 + + + + Chambers, C. D., Mattingley, J. B., & Moss, S. A. (2002). The octave illusion revisited: suppression or fusion between ears? Journal of Experimental Psychology: Human Perception and Performance, 28(6), 1288–1302. https://doi.org/10.1037/0096-1523.28.6.1288 + + 10.1037/0096-1523.28.6.1288 + 12542128 + + + + Chambers, C. D., Mattingley, J. B., & Moss, S. A. (2004a). Reconsidering evidence for the suppression model of the octave illusion. Psychonomic Bulletin & Review, 11(4), 642–666. https://doi.org/10.3758/BF03196617 + + 10.3758/BF03196617 + + + + Chambers, C. D., Mattingley, J. B., & Moss, S. A. (2004b). The suppression model remains unsound: A reply to Deutsch. Psychonomic Bulletin & Review, 11(4), 677–680. https://doi.org/10.3758/BF03196619 + + 10.3758/BF03196619 + + + + Champely, S. (2020). pwr: Basic Functions for Power Analysis. R package, version 1.3–0, URL: https://CRAN.R-project.org/package=pwr + + + Cherry, E. C. (1953). Some experiments on the recognition of speech, with one and with two ears. The Journal of the Acoustical Society of America, 25(5), 975–979. https://doi.org/10.1121/1.1907229 + + 10.1121/1.1907229 + + + + Deutsch, D. (1974a). An auditory illusion. The Journal of the Acoustical Society of America., 55, S18. https://doi.org/10.1121/1.1919587 + + 10.1121/1.1919587 + + + + Deutsch, D. (1974b). An auditory illusion. Nature, 251(5473), 307–309. https://doi.org/10.1038/251307a0 + + 10.1038/251307a0 + 4427654 + + + + Deutsch, D. (1975). Musical illusions. Scientific American, 233(4), 92–105. + + 10.1038/scientificamerican1075-92 + 1162325 + + + + Deutsch, D. (1978). Lateralization by frequency for repeating sequences of dichotic 400 Hz and 800 Hz tones. The Journal of the Acoustical Society of America, 63, 184–186. https://doi.org/10.1121/1.381710 + + 10.1121/1.381710 + 632409 + + + + Deutsch, D. (1980a). Ear dominance and sequential interactions. Journal of the Acoustical Society of America, 67(1), 220–228 + + + Deutsch, D. (1980b). The octave illusion and the what-where connection. In R. S. Nickerson (ed.), Attention and performance (Vol. VIII, pp. 575–594). Hillsdale, NJ: Erlbaum. + + + Deutsch, D. (1981). The octave illusion and auditory perceptual integration. Hearing Research and Theory, 1(99), 142. + + + Deutsch, D. (1983). The octave illusion in relation to handedness and familial handedness background. Neuropsychologia, 21(3), 289–293. + + + Deutsch, D. (1988). Lateralization and sequential relationships in the octave illusion. The Journal of the Acoustical Society of America, 83(1), 365–369. https://doi.org/10.1121/1.396249 + + 10.1121/1.396249 + 3343449 + + + + Deutsch, D. (2004a). The octave illusion revisited again. Journal of Experimental Psychology: Human Perception and Performance, 30(2), 355. https://doi.org/10.1037/0096-1523.30.2.355 + + 10.1037/0096-1523.30.2.355 + 15053694 + + + + Deutsch, D. (2004b). Reply to “Reconsidering evidence for the suppression model of the octave illusion”, by CD Chambers, JB Mattingley, and SA Moss. Psychonomic Bulletin & Review, 11(4), 667–676. https://doi.org/10.3758/BF03196618 + + 10.3758/BF03196618 + + + + Deutsch, D., & Roll, P. L. (1976). Separate “what” and “where” decision mechanisms in processing a dichotic tonal sequence. Journal of Experimental Psychology: Human Perception and Performance, 2(1), 23. https://doi.org/10.1037/0096-1523.2.1.23 + + 10.1037/0096-1523.2.1.23 + 1262796 + + + + Fastl, H., & Zwicker, E. (2007). Psychoacoustics. Springer. + + + Henning, G. B. (1966). Frequency discrimination of random-amplitude tones. The Journal of the Acoustical Society of America, 39(2), 336–339. https://doi.org/10.1121/1.1939478 + + 10.1121/1.1939478 + 5908437 + + + + Herholz, S. C., & Zatorre, R. J. (2012). Musical training as a framework for brain plasticity: behavior, function, and structure. Neuron, 76(3), 486–502. https://doi.org/10.1016/j.neuron.2012.10.011 + + 10.1016/j.neuron.2012.10.011 + 23141061 + + + + Horbach, M., Verhey, J. L., & Hots, J. (2018). On the pitch strength of bandpass noise in normal-hearing and hearing-impaired listeners. Trends in Hearing., 22, 2331216518787067. https://doi.org/10.1177/2331216518787067 + + 10.1177/2331216518787067 + 30009682 + 6048668 + + + + Houtsma, A. J., & Goldstein, J. L. (1972). The central origin of the pitch of complex tones: evidence from musical interval recognition. The Journal of the Acoustical Society of America, 51(2B), 520–529. https://doi.org/10.1121/1.1912873 + + 10.1121/1.1912873 + + + + Jonas Brännström, K., & Nilsson, P. (2011). Octave illusion elicited by overlapping narrowband noises. The Journal of the Acoustical Society of America, 129(5), 3213–3220. https://doi.org/10.1121/1.3571425 + + 10.1121/1.3571425 + 21568423 + + + + Lamminmäki, S., & Hari, R. (2000). Auditory cortex activation associated with octave illusion. NeuroReport, 11(7), 1469–1472. + + 10.1097/00001756-200005150-00022 + 10841359 + + + + McClurkin, R. H., & Hall, J. W., III. (1981). Pitch and timbre in a two-tone dichotic auditory illusion. The Journal of the Acoustical Society of America, 69(2), 592–594. https://doi.org/10.1121/1.385376 + + 10.1121/1.385376 + 7462482 + + + + Oehler, M., & Reuter, C. (2013). The octave illusion and handedness: A replication of Deutsch’s 1974 study. Musicae Scientiae, 17(3), 277–289. + + + R Core Team. (2022). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. URL: https://www.R-project.org/ + + + Rea, L. M., & Parker, R. A. (1992). Designing and conducting survey research. Jossey-Bass. + + + Ross, J., Tervaniemi, M., & Näätänen, R. (1996). Neural mechanisms of the octave illusion: electrophysiological evidence for central origin. NeuroReport, 8(1), 303–306. https://doi.org/10.1097/00001756-199612200-00060 + + 10.1097/00001756-199612200-00060 + 9051800 + + + + Shepard, R. N. (1964). Circularity in judgments of relative pitch. The Journal of the Acoustical Society of America, 36(12), 2346–2353. https://doi.org/10.1121/1.1919362 + + 10.1121/1.1919362 + + + + Shower, E. G., & Biddulph, R. (1931). Differential pitch sensitivity of the ear. The Journal of the Acoustical Society of America, 3(2A), 275–287. https://doi.org/10.1121/1.1915561 + + 10.1121/1.1915561 + + + + Tanaka, K., Kurasaki, H., & Kuriki, S. (2018). Neural representation of octave illusion in the human cortex revealed with functional magnetic resonance imaging. Hearing Research, 359, 85–90. https://doi.org/10.1016/j.heares.2018.01.001 + + 10.1016/j.heares.2018.01.001 + 29352610 + + + + Wever, E. G., & Wedell, C. H. (1941). Pitch discrimination at high frequencies. Psychological Bulletin, 38, 727. + + + +
+ + + 36809391 + + 2023 + 02 + 22 + +
+ + 1945-7170 + + + 2023 + Feb + 21 + + + Endocrinology + Endocrinology + + It's Not Just for Pain: A New Metabolic Function of Aspirin. + bqad036 + 10.1210/endocr/bqad036 + + + Perry + Rachel J + RJ + 0000-0003-0748-8064 + + Departments of Internal Medicine (Endocrinology) and Cellular & Molecular Physiology, Yale School of Medicine. + + + + eng + + Editorial + Comment + + + 2023 + 02 + 21 + +
+ + United States + Endocrinology + 0375040 + 0013-7227 + + IM + + + Endocrinology. 2023 Jan 9;164(3): + 36592127 + + + + Aspirin + Hepatic Glucose Production + Inositol 3-Triphosphate + Phospholipase C + +
+ + + + 2023 + 01 + 31 + + + 2023 + 02 + 14 + + + 2023 + 02 + 20 + + + 2023 + 2 + 22 + 13 + 45 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809391 + 7049714 + 10.1210/endocr/bqad036 + + +
+ + + 36809394 + + 2023 + 02 + 22 + +
+ + 1558-5646 + + + 2023 + Feb + 21 + + + Evolution; international journal of organic evolution + Evolution + + Multi-generation selective landscapes and sub-lethal injuries in stickleback. + qpad032 + 10.1093/evolut/qpad032 + + The interaction between predation landscape and phenotypic variability within prey populations is of substantial significance in evolutionary biology. Extending from several decades of studies at a remote freshwater lake on Haida Gwaii, western Canada, we analyse the incidence of predator-induced sub-lethal injuries in 8069 wild-captured threespine stickleback (Gasterosteus aculeatus) and using cohort analyses test whether the distribution of injuries informs the selective landscape influencing the bell-shaped frequency distribution of the traits. Our results indicate that 1: the incidence of injuries varies among phenotypes differing in the number and position of lateral plates, 2: these differences occur only among younger fish, 3: the incidence of injuries is inversely related to the estimated population frequencies of plate phenotypes, with the modal phenotype generally having the fewest injuries, 4: direct estimates of selective differentials and relative fitness based on analyses of 1735 fish from six independent yearly cohorts indicates statistically informative elevated differentials in phenotypes with greater number of plates and elevated relative fitness of non-modal phenotypes and 5: there are significant differences among yearly cohorts in strength and direction of selection, and an increased prevalence of diversifying versus stabilizing selection despite longer term stasis (four decades) in trait means. We conclude that the presence of multiple 'optimal' phenotypes complements the renewed interests in quantifying short-term temporal or spatial variation in ecological processes in studies of fitness landscapes and intrapopulation variability. + © The Author(s) 2023. Published by Oxford University Press on behalf of The Society for the Study of Evolution (SSE). All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. + + + + Reimchen + Thomas E + TE + 0000-0002-5578-8531 + + Department of Biology, University of Victoria, PO Box 1700, Victoria, B.C., Canada. + + + + Bergstrom + Carolyn A + CA + + Department of Natural Sciences, Biology Program, University of Alaska, Juneau, AK 99801 USA. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Evolution + 0373224 + 0014-3820 + + IM + + + Gasterosteus + + Fitness + fluctuating selection + lateral plates + predator-prey + unsuccessful predation + +
+ + + + 2022 + 11 + 17 + + + 2023 + 2 + 22 + 13 + 46 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809394 + 7049771 + 10.1093/evolut/qpad032 + + +
+ + + 36809386 + + 2023 + 02 + 22 + +
+ + 1430-2772 + + + 2023 + Feb + 21 + + + Psychological research + Psychol Res + + What do you focus on? An investigation of goal focus from childhood to old age. + 10.1007/s00426-023-01804-0 + + Goals constitute an important construct in developmental psychology. They represent a central way in which individuals shape their development. Here, we present two studies on age-related differences in one important goal dimension, goal focus, that is, the relative salience of the means and ends of goal pursuit. Extant studies on age-related differences in adults suggest a shift from focusing on the ends to focusing on the means across adulthood. The current studies aimed to expand this research to encompass the entire lifespan including childhood. The first cross-sectional study included participants spanning from early childhood into old age (N = 312, age range: 3-83 years) and used a multimethodological approach comprising eye tracking, behavioral, and verbal measures of goal focus. The second study investigated the verbal measures of the first study in more detail in an adult sample (N = 1550, age range: 17-88 years). Overall, the results do not show a clear pattern, making them difficult to interpret. There was little convergence of the measures, pointing to the difficulties in assessing a construct such as goal focus across a large range of age groups differing in social-cognitive and verbal skills. + © 2023. The Author(s). + + + + Moersdorf + Lea + L + + Department of Psychology, University of Zurich, Binzmuehlestrasse 14, Box 21, 8050, Zurich, Switzerland. moersdorf@psychologie.uzh.ch. + + + + Freund + Alexandra M + AM + + Department of Psychology, University of Zurich, Binzmuehlestrasse 14, Box 21, 8050, Zurich, Switzerland. freund@psychologie.uzh.ch. + + + University Research Priority Program "Dynamics of Healthy Aging", University of Zurich, Zurich, Switzerland. freund@psychologie.uzh.ch. + + + NCCR LIVES, Lausanne, Switzerland. freund@psychologie.uzh.ch. + + + + Daum + Moritz M + MM + + Department of Psychology, University of Zurich, Binzmuehlestrasse 14, Box 21, 8050, Zurich, Switzerland. moritz.daum@uzh.ch. + + + Jacobs Center for Productive Youth Development, University of Zurich, Zurich, Switzerland. moritz.daum@uzh.ch. + + + + eng + + + F-63206-18-01 + Jacobs Foundation + + + + F-63206-18-01 + Jacobs Foundation + + + + F-63206-18-01 + Jacobs Foundation + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Psychol Res + 0435062 + 0340-0727 + + IM +
+ + + + 2022 + 10 + 28 + + + 2023 + 02 + 06 + + + 2023 + 2 + 22 + 13 + 45 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809386 + 10.1007/s00426-023-01804-0 + 10.1007/s00426-023-01804-0 + + + + Baumeister, R. F., Vohs, K. D., & Funder, D. C. (2007). Psychology as the science of self-reports and finger movements: Whatever happened to actual behavior? Perspectives on Psychological Science, 2, 396–403. https://doi.org/10.1111/j.1745-6916.2007.00051.x + + 10.1111/j.1745-6916.2007.00051.x + 26151975 + + + + Brainerd, C. J., & Reyna, V. F. (2004). Fuzzy-trace theory and memory development. Developmental Review, 24, 396–439. https://doi.org/10.1016/j.dr.2004.08.005 + + 10.1016/j.dr.2004.08.005 + + + + Buon, M., Jacob, P., Margules, S., Brunet, I., Dutat, M., Cabrol, D., & Dupoux, E. (2014). Friend or foe? Early social evaluation of human interactions. 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+ + + 36809396 + + 2023 + 02 + 22 + +
+ + 2050-7518 + + + 2023 + Feb + 21 + + + Journal of materials chemistry. B + J Mater Chem B + + Core-shell bioceramic fiber-derived biphasic granules with adjustable core compositions for tuning bone regeneration efficacy. + 10.1039/d2tb02702j + + Silicate-based biomaterials-clinically applied fillers and promising candidates-can act as a highly biocompatible substrate for osteostimulative osteogenic cell growth in vitro and in vivo. These biomaterials have been proven to exhibit a variety of conventional morphologies in bone repair, including scaffolds, granules, coatings and cement pastes. Herein, we aim to develop a series of novel bioceramic fiber-derived granules with core-shell structures which have a hardystonite (HT) shell layer and changeable core components-that is, the chemical compositions of a core layer can be tuned to include a wide range of silicate candidates (e.g., wollastonite (CSi)) with doping of functional ions (e.g., Mg, P, and Sr). Meanwhile, it is versatile to control the biodegradation and bioactive ion release sufficiently for stimulating new bone growth after implantation. Our method employs rapidly gelling ultralong core-shell CSi@HT fibers derived from different polymer hydrosol-loaded inorganic powder slurries through the coaxially aligned bilayer nozzles, followed by cutting and sintering treatments. It was demonstrated that the nonstoichiometric CSi core component could contribute to faster bio-dissolution and biologically active ion release in tris buffer in vitro. The rabbit femoral bone defect repair experiments in vivo indicated that core-shell bioceramic granules with an 8% P-doped CSi-core could significantly stimulate osteogenic potential favorable for bone repair. It is worth concluding that such a tunable component distribution strategy in fiber-type bioceramic implants may develop new-generation composite biomaterials endowed with time-dependent biodegradation and high osteostimulative activities for a range of bone repair applications in situ. + + + + Bao + Zhaonan + Z + + Bio-nanomaterials and Regenerative Medicine Research Division, Zhejiang-California International Nanosystem Institute, Zhejiang University, Hangzhou 310058, China. zhrgou@zju.edu.cn. + + + + Yang + Jun + J + + Department of Orthopaedic Surgery, Rui'an People's Hospital & the 3rd Hospital Affiliated to Wenzhou Medical University, Rui'an 325200, China. + + + + Shen + Jian + J + + Department of Orthopedics, the First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, Zhejiang, 310003, China. mds@zju.edu.cn. + + + + Wang + Cong + C + + Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310008, China. + + + + Li + Yifan + Y + http://orcid.org/0000-0001-7817-3241 + + Department of Orthopedics, the First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, Zhejiang, 310003, China. mds@zju.edu.cn. + + + + Zhang + Yan + Y + + Bio-nanomaterials and Regenerative Medicine Research Division, Zhejiang-California International Nanosystem Institute, Zhejiang University, Hangzhou 310058, China. zhrgou@zju.edu.cn. + + + + Yang + Guojing + G + + Department of Orthopaedic Surgery, Rui'an People's Hospital & the 3rd Hospital Affiliated to Wenzhou Medical University, Rui'an 325200, China. + + + + Zhong + Cheng + C + http://orcid.org/0000-0002-9241-2840 + + Department of Orthopedics, the First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, Zhejiang, 310003, China. mds@zju.edu.cn. + + + + Xu + Sanzhong + S + http://orcid.org/0000-0002-1881-2723 + + Department of Orthopedics, the First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, Zhejiang, 310003, China. mds@zju.edu.cn. + + + + Xie + Lijun + L + + Bio-nanomaterials and Regenerative Medicine Research Division, Zhejiang-California International Nanosystem Institute, Zhejiang University, Hangzhou 310058, China. zhrgou@zju.edu.cn. + + + + Shen + Miaoda + M + http://orcid.org/0000-0002-7450-4645 + + Department of Orthopedics, the First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, Zhejiang, 310003, China. mds@zju.edu.cn. + + + + Gou + Zhongru + Z + + Bio-nanomaterials and Regenerative Medicine Research Division, Zhejiang-California International Nanosystem Institute, Zhejiang University, Hangzhou 310058, China. zhrgou@zju.edu.cn. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + J Mater Chem B + 101598493 + 2050-750X + + IM +
+ + + + 2023 + 2 + 22 + 13 + 46 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809396 + 10.1039/d2tb02702j + + +
+ + + 36809395 + + 2023 + 02 + 22 + +
+ + 1615-2573 + + + 2023 + Feb + 21 + + + Heart and vessels + Heart Vessels + + Association of peak C-reactive protein with long-term clinical outcomes in patients with ST-segment elevation myocardial infarction. + 10.1007/s00380-023-02250-z + + Peak C-reactive protein (CRP) levels following ST-segment elevation myocardial infarction (STEMI) are associated with left ventricular thrombus formation or cardiac rupture. However, the impact of peak CRP on long-term outcomes in patients with STEMI is not completely understood. The purpose of this retrospective study was to compare the long-term all-cause death after STEMI between patients with and without high peak CRP levels. We included 594 patients with STEMI, and divided them into the high CRP group (n = 119) and the low-moderate CRP group (n = 475) according to the quintile of peak CRP levels. The primary endpoint was all-cause death after the discharge of the index admission. The mean peak CRP level was 19.66 ± 5.14 mg/dL in the high CRP group, whereas that was 6.43 ± 3.86 mg/dL in the low-moderate CRP group (p < 0.001). During the median follow-up duration of 1045 days (Q1 284 days, Q3 1603 days), a total of 45 all-cause deaths were observed. The Kaplan-Meier curves showed that all-cause death was more frequently observed in the high CRP group than in the low-moderate CRP group (p = 0.002). The multivariate Cox hazard analysis revealed that high CRP was significantly associated with all-cause death (hazard ratio 2.325, 95% confidence interval 1.246-4.341, p = 0.008) after controlling for confounding factors. In conclusion, high peak CRP was significantly associated with all-cause death in patients with STEMI. Our results suggest that peak CRP may be useful to stratify patients with STEMI for the risk of future death. + © 2023. Springer Nature Japan KK, part of Springer Nature. + + + + Hori + Yoichi + Y + + Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya, Saitama City, 330-8503, Japan. + + + + Sakakura + Kenichi + K + http://orcid.org/0000-0003-3566-0394 + + Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya, Saitama City, 330-8503, Japan. ksakakura@jichi.ac.jp. + + + + Jinnouchi + Hiroyuki + H + + Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya, Saitama City, 330-8503, Japan. + + + + Taniguchi + Yousuke + Y + + Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya, Saitama City, 330-8503, Japan. + + + + Tsukui + Takunori + T + + Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya, Saitama City, 330-8503, Japan. + + + + Watanabe + Yusuke + Y + + Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya, Saitama City, 330-8503, Japan. + + + + Yamamoto + Kei + K + + Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya, Saitama City, 330-8503, Japan. + + + + Seguchi + Masaru + M + + Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya, Saitama City, 330-8503, Japan. + + + + Wada + Hiroshi + H + + Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya, Saitama City, 330-8503, Japan. + + + + Fujita + Hideo + H + + Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya, Saitama City, 330-8503, Japan. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Japan + Heart Vessels + 8511258 + 0910-8327 + + IM + + Acute myocardial infarction + C-reactive protein + Clinical outcomes + +
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+ + + 36809388 + + 2023 + 02 + 22 + +
+ + 1432-0614 + + + 2023 + Feb + 21 + + + Applied microbiology and biotechnology + Appl Microbiol Biotechnol + + AnAzf1 acts as a positive regulator of ochratoxin A biosynthesis in Aspergillus niger. + 10.1007/s00253-023-12404-8 + + Aspergillus niger produces genotoxic and carcinogenic ochratoxin A (OTA) that severely threatens human and animal health. Transcription factor Azf1 is essential in regulating fungal cell development and primary metabolism. However, its effect and mechanism on secondary metabolism are unclear. Here, we characterized and deleted a Azf1 homolog gene, An15g00120 (AnAzf1), in A. niger, which completely blocked OTA production, and repressed the OTA cluster genes, p450, nrps, hal, and bzip at the transcriptional level. The results indicated that AnAzf1 was a positive regulator of OTA biosynthesis. Transcriptome sequencing results showed that the AnAzf1 deletion significantly upregulated antioxidant genes and downregulated oxidative phosphorylation genes. Enzymes involved in reactive oxygen species (ROS) scavenging, including catalase (CAT) and peroxidase (POD) were increased, and the corresponding ROS levels were decreased. Upregulation of genes (cat, catA, hog1, and gfd) in the MAPK pathway and downregulation of genes in iron homeostasis were associated with decreased ROS levels, linking the altered MAPK pathway and iron homeostasis to lower ROS levels caused by AnAzf1 deletion. Additionally, enzymes including complex I (NADH-ubiquinone oxidoreductase), and complex V (ATP synthase), as well as ATP levels, were significantly decreased, indicating impaired oxidative phosphorylation caused by the AnAzf1-deletion. During lower ROS levels and impaired oxidative phosphorylation, OTA was not produced in ∆AnAzf1. Together, these results strongly suggested that AnAzf1 deletion blocked OTA production in A. niger by a synergistic interference of ROS accumulation and oxidative phosphorylation. KEY POINTS: • AnAzf1 positively regulated OTA biosynthesis in A. niger. • Deletion of AnAzf1 decreased ROS levels and impaired oxidative phosphorylation. • An altered MAPK pathway and iron homeostasis were associated with lower ROS levels. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Wei + Shan + S + + College of Bioengineering, Henan University of Technology, Zhengzhou, 450001, People's Republic of China. + + + Henan Provincial Key Laboratory of Biological Processing and Nutritional Function of Wheat, Zhengzhou, 450001, People's Republic of China. + + + + Hu + Chaojiang + C + + College of Bioengineering, Henan University of Technology, Zhengzhou, 450001, People's Republic of China. + + + Henan Provincial Key Laboratory of Biological Processing and Nutritional Function of Wheat, Zhengzhou, 450001, People's Republic of China. + + + + Zhang + Yige + Y + + College of Bioengineering, Henan University of Technology, Zhengzhou, 450001, People's Republic of China. + + + Henan Provincial Key Laboratory of Biological Processing and Nutritional Function of Wheat, Zhengzhou, 450001, People's Republic of China. + + + + Lv + Yangyong + Y + + College of Bioengineering, Henan University of Technology, Zhengzhou, 450001, People's Republic of China. + + + Henan Provincial Key Laboratory of Biological Processing and Nutritional Function of Wheat, Zhengzhou, 450001, People's Republic of China. + + + + Zhang + Shuaibing + S + + College of Bioengineering, Henan University of Technology, Zhengzhou, 450001, People's Republic of China. + + + Henan Provincial Key Laboratory of Biological Processing and Nutritional Function of Wheat, Zhengzhou, 450001, People's Republic of China. + + + + Zhai + Huanchen + H + + College of Bioengineering, Henan University of Technology, Zhengzhou, 450001, People's Republic of China. + + + Henan Provincial Key Laboratory of Biological Processing and Nutritional Function of Wheat, Zhengzhou, 450001, People's Republic of China. + + + + Hu + Yuansen + Y + http://orcid.org/0000-0002-5611-8783 + + College of Bioengineering, Henan University of Technology, Zhengzhou, 450001, People's Republic of China. huyuansen@haut.edu.cn. + + + Henan Provincial Key Laboratory of Biological Processing and Nutritional Function of Wheat, Zhengzhou, 450001, People's Republic of China. huyuansen@haut.edu.cn. + + + + eng + + + 31401269 + the High-level Talent Scientific Research Fund Project of Henan University of Technology + + + + 31972176 + the National Natural Science Foundation of China + + + + 2020ZKCJ01 + the Innovative Funds Plan of Henan University of Technology + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Appl Microbiol Biotechnol + 8406612 + 0175-7598 + + IM + + AnAzf1, + Aspergillus niger + Ochratoxin A, + Oxidative phosphorylation, + ROS, + +
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+ + + 36809398 + + 2023 + 02 + 22 + +
+ + 1753-4887 + + + 2023 + Feb + 21 + + + Nutrition reviews + Nutr Rev + + Considerations for developing a targeted amino acid supplement for people with Parkinson's disease that promotes health while accounting for pathophysiology and medication interference. + nuad008 + 10.1093/nutrit/nuad008 + + For individuals with Parkinson's disease (PD), dietary habits affect disease symptoms, progression, and overall health. Protein consumption is of great interest because of the direct and indirect effects of specific amino acids (AAs) on disease progression and interference with levodopa medication. Proteins comprise 20 distinct AAs with varying effects on overall health, disease progression, and medication interference. Therefore, it is important to consider both the potential beneficial and detrimental effects of each AA when considering supplementation for an individual with PD. Such consideration is of particular importance because PD pathophysiology, altered dietary patterns associated with PD, and competitive absorption with levodopa have been shown to result in characteristically altered AA profiles (eg, some AAs are stored in excess while others are deficient). To address this problem, considerations for the development of a precision nutritional supplement that targets AAs specific to the needs of people with PD are discussed. The objective of this review is to provide a theoretical framework for such a supplement, detailing the current state of knowledge relating relevant evidence to such a supplement, and highlighting areas of future research. Specifically, the general need for such a supplement is discussed before a systematic examination is provided of the potential benefits and risks of dietary supplementation of each AA in people with PD. As a part of this discussion, evidence-based recommendations are provided regarding the inclusion or exclusion of each AA for such a supplement for people with PD, and areas are highlighted where additional research is needed. + © The Author(s) 2023. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. + + + + Earp + Jacob E + JE + 0000-0003-4524-7886 + + Department of Kinesiology, University of Connecticut, Storrs, Connecticut, USA. + + + + Colon-Semenza + Cristina + C + + Department of Kinesiology, University of Connecticut, Storrs, Connecticut, USA. + + + + LoBuono + Dara L + DL + + Department of Health and Exercise Science, Rowan University, Glassboro, New Jersey, USA. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Nutr Rev + 0376405 + 0029-6643 + + IM + + Parkinson’s disease + amino acid + dietary protein + essential amino acid + levodopa + pharmacokinetics + +
+ + + + 2023 + 2 + 22 + 13 + 46 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809398 + 7049590 + 10.1093/nutrit/nuad008 + + +
+ + + 36809389 + + 2023 + 02 + 22 + +
+ + 1432-0614 + + + 2023 + Feb + 21 + + + Applied microbiology and biotechnology + Appl Microbiol Biotechnol + + Development of a novel double-antibody sandwich quantitative ELISA for detecting SADS-CoV infection. + 10.1007/s00253-023-12432-4 + + Swine acute diarrhea syndrome coronavirus (SADS-CoV) is an emerging swine enteric alphacoronavirus that can cause acute diarrhea, vomiting, dehydration, and death of newborn piglets. In this study, we developed a double-antibody sandwich quantitative enzyme-linked immunosorbent assay (DAS-qELISA) for detection of SADS-CoV by using an anti-SADS-CoV N protein rabbit polyclonal antibody (PAb) and a specific monoclonal antibody (MAb) 6E8 against the SADS-CoV N protein. The PAb was used as the capture antibodies and HRP-labeled 6E8 as the detector antibody. The detection limit of the developed DAS-qELISA assay was 1 ng/mL of purified antigen and 101.08TCID50/mL of SADS-CoV, respectively. Specificity assays showed that the developed DAS-qELISA has no cross-reactivity with other swine enteric coronaviruses, such as porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), and porcine deltacoronavirus (PDCoV). Three-day-old piglets were challenged with SADS-CoV and collected anal swab samples which were screened for the presence of SADS-CoV by using DAS-qELISA and reverse transcriptase PCR (RT-PCR). The coincidence rate of the DAS-qELISA and RT-PCR was 93.93%, and the kappa value was 0.85, indicating that DAS-qELISA is a reliable method for applying antigen detection of clinical samples. KEY POINTS: • The first double-antibody sandwich quantitative enzyme-linked immunosorbent assay for detection SADS-CoV infection. • The custom ELISA is useful for controlling the SADS-CoV spread. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Cao + Liyan + L + + Institute of Urban Agriculture, Chinese Academy of Agricultural Sciences, Chengdu, China. + + + State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, National Foot and Mouth Diseases Reference Laboratory, Chinese Academy of Agricultural Sciences, Lanzhou, China. + + + Chengdu National Agricultural Science and Technology Center, Chengdu, China. + + + + Kong + Xiangyu + X + + Institute of Urban Agriculture, Chinese Academy of Agricultural Sciences, Chengdu, China. + + + State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, National Foot and Mouth Diseases Reference Laboratory, Chinese Academy of Agricultural Sciences, Lanzhou, China. + + + Chengdu National Agricultural Science and Technology Center, Chengdu, China. + + + + Zhang + Yu + Y + + Institute of Urban Agriculture, Chinese Academy of Agricultural Sciences, Chengdu, China. + + + State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, National Foot and Mouth Diseases Reference Laboratory, Chinese Academy of Agricultural Sciences, Lanzhou, China. + + + Chengdu National Agricultural Science and Technology Center, Chengdu, China. + + + + Suo + Xuepeng + X + + Institute of Urban Agriculture, Chinese Academy of Agricultural Sciences, Chengdu, China. + + + State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, National Foot and Mouth Diseases Reference Laboratory, Chinese Academy of Agricultural Sciences, Lanzhou, China. + + + Chengdu National Agricultural Science and Technology Center, Chengdu, China. + + + + Li + Xiangtong + X + + Institute of Urban Agriculture, Chinese Academy of Agricultural Sciences, Chengdu, China. + + + State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, National Foot and Mouth Diseases Reference Laboratory, Chinese Academy of Agricultural Sciences, Lanzhou, China. + + + Chengdu National Agricultural Science and Technology Center, Chengdu, China. + + + + Duan + Yueyue + Y + + Institute of Urban Agriculture, Chinese Academy of Agricultural Sciences, Chengdu, China. + + + State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, National Foot and Mouth Diseases Reference Laboratory, Chinese Academy of Agricultural Sciences, Lanzhou, China. + + + Chengdu National Agricultural Science and Technology Center, Chengdu, China. + + + + Yuan + Cong + C + + Institute of Urban Agriculture, Chinese Academy of Agricultural Sciences, Chengdu, China. + + + State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, National Foot and Mouth Diseases Reference Laboratory, Chinese Academy of Agricultural Sciences, Lanzhou, China. + + + Chengdu National Agricultural Science and Technology Center, Chengdu, China. + + + + Zheng + Haixue + H + + State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, National Foot and Mouth Diseases Reference Laboratory, Chinese Academy of Agricultural Sciences, Lanzhou, China. haixuezheng@163.com. + + + + Wang + Qi + Q + http://orcid.org/0000-0001-6942-2410 + + Institute of Urban Agriculture, Chinese Academy of Agricultural Sciences, Chengdu, China. qiwang@caas.cn. + + + State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, National Foot and Mouth Diseases Reference Laboratory, Chinese Academy of Agricultural Sciences, Lanzhou, China. qiwang@caas.cn. + + + Chengdu National Agricultural Science and Technology Center, Chengdu, China. qiwang@caas.cn. + + + + eng + + + 2022YFN0008 + Sichuan Provincial Administration of Traditional Chinese Medicine + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Appl Microbiol Biotechnol + 8406612 + 0175-7598 + + IM + + Antigen detection + DAS-qELISA + Monoclonal antibody + Nucleocapsid protein + Swine acute diarrhea syndrome coronavirus (SADS-CoV) + +
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+ + + 36809397 + + 2023 + 02 + 22 + +
+ + 1931-7573 + + 18 + 1 + + 2023 + Feb + 21 + + + Nanoscale research letters + Nanoscale Res Lett + + Performance improvement of a tunnel junction memristor with amorphous insulator film. + + 20 + + 10.1186/s11671-023-03800-0 + + This study theoretically demonstrated the oxygen vacancy (VO2+)-based modulation of a tunneling junction memristor (TJM) with a high and tunable tunneling electroresistance (TER) ratio. The tunneling barrier height and width are modulated by the VO2+-related dipoles, and the ON and OFF-state of the device are achieved by the accumulation of VO2+ and negative charges near the semiconductor electrode, respectively. Furthemore, the TER ratio of TJMs can be tuned by varying the density of the ion dipoles (Ndipole), thicknesses of ferroelectric-like film (TFE) and SiO2 (Tox), doping concentration (Nd) of the semiconductor electrode, and the workfunction of the top electrode (TE). An optimized TER ratio can be achieved with high oxygen vacancy density, relatively thick TFE, thin Tox, small Nd, and moderate TE workfunction. + © 2023. The Author(s). + + + + Liu + Fenning + F + + State Key Discipline Laboratory of Wide Band Gap Semiconductor Technology, School of Microelectronics, Xidian University, Xi'an, 710071, People's Republic of China. + + + + Peng + Yue + Y + + State Key Discipline Laboratory of Wide Band Gap Semiconductor Technology, School of Microelectronics, Xidian University, Xi'an, 710071, People's Republic of China. ypeng@xidian.edu.cn. + + + + Liu + Yan + Y + + State Key Discipline Laboratory of Wide Band Gap Semiconductor Technology, School of Microelectronics, Xidian University, Xi'an, 710071, People's Republic of China. xdliuyan@xidian.edu.cn. + + + + Xiao + Wenwu + W + + Xi'an UniIC Semiconductors, Xi'an, 710075, China. + + + + Hao + Yue + Y + + State Key Discipline Laboratory of Wide Band Gap Semiconductor Technology, School of Microelectronics, Xidian University, Xi'an, 710071, People's Republic of China. + + + + Han + Genquan + G + + State Key Discipline Laboratory of Wide Band Gap Semiconductor Technology, School of Microelectronics, Xidian University, Xi'an, 710071, People's Republic of China. + + + Emerging Device and Chip Laboratory, Hangzhou Institute of Technology, Xidian University, Hangzhou, 311200, People's Republic of China. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
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+ + + 36809393 + + 2023 + 02 + 22 + +
+ + 1573-9686 + + + 2023 + Feb + 21 + + + Annals of biomedical engineering + Ann Biomed Eng + + Tuning the Microenvironment to Create Functionally Distinct Mesenchymal Stromal Cell Spheroids. + 10.1007/s10439-023-03162-9 + + Mesenchymal stromal cells (MSCs) are under investigation for wound healing and tissue regeneration due to their potent secretome. Compared to monodisperse cells, MSC spheroids exhibit increased cell survival and enhanced secretion of endogenous factors such as vascular endothelial growth factor (VEGF) and prostaglandin E2 (PGE2), two key factors in wound repair. We previously upregulated the proangiogenic potential of homotypic MSC spheroids by manipulating microenvironmental culture conditions. However, this approach depends on the responsiveness of host endothelial cells (ECs)-a limitation when attempting to restore large tissue deficits and for patients with chronic wounds in which ECs are dysfunctional and unresponsive. To address this challenge, we used a Design of Experiments (DOE) approach to engineer functionally distinct MSC spheroids that maximize VEGF production (VEGFMAX) or PGE2 production (PGE2,MAX) while incorporating ECs that could serve as the basic building blocks for vessel formation. VEGFMAX produced 22.7-fold more VEGF with enhanced endothelial cell migration compared to PGE2,MAX, while PGE2,MAX produced 16.7-fold more PGE2 with accelerated keratinocyte migration compared to VEGFMAX. When encapsulated together in engineered protease-degradable hydrogels as a model of cell delivery, VEGFMAX and PGE2,MAX spheroids exhibited robust spreading into the biomaterial and enhanced metabolic activity. The distinct bioactivities of these MSC spheroids demonstrate the highly tunable nature of spheroids and provide a new approach to leverage the therapeutic potential of cell-based therapies. + © 2023. The Author(s). + + + + Thai + Victoria L + VL + http://orcid.org/0000-0003-1009-6432 + + Department of Biomedical Engineering, University of California, Davis, Davis, CA, 95616, USA. + + + Department of Orthopaedic Surgery, UC Davis Health, 4860 Y Street, Suite 3800, Sacramento, CA, 95817, USA. + + + + Candelas + Diego O + DO + + Department of Biomedical Engineering, University of California, Davis, Davis, CA, 95616, USA. + + + + Leach + J Kent + JK + http://orcid.org/0000-0002-1673-3335 + + Department of Biomedical Engineering, University of California, Davis, Davis, CA, 95616, USA. jkleach@ucdavis.edu. + + + Department of Orthopaedic Surgery, UC Davis Health, 4860 Y Street, Suite 3800, Sacramento, CA, 95817, USA. jkleach@ucdavis.edu. + + + + eng + + + R01 DE025475 + DE + NIDCR NIH HHS + United States + + + R01 DE025899 + DE + NIDCR NIH HHS + United States + + + R01 AR079211 + AR + NIAMS NIH HHS + United States + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Ann Biomed Eng + 0361512 + 0090-6964 + + IM + + Design of experiments + Endothelial cell + Mesenchymal stromal cell + PEG-4MAL + Spheroids + Wound healing + +
+ + + + 2022 + 11 + 08 + + + 2023 + 02 + 06 + + + 2023 + 2 + 22 + 13 + 45 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809393 + 10.1007/s10439-023-03162-9 + 10.1007/s10439-023-03162-9 + + + + Ahangar, P., S. J. Mills, and A. J. Cowin. Mesenchymal stem cell secretome as an emerging cell-free alternative for improving wound repair. Int. J. Mol. Sci. 21(19):5, 2020 + + 10.3390/ijms21197038 + + + + An, Y., W. J. Liu, P. Xue, Y. Ma, L. Q. Zhang, B. Zhu, et al. Autophagy promotes msc-mediated vascularization in cutaneous wound healing via regulation of vegf secretion. Cell Death Dis. 9(2):58, 2018 + + 10.1038/s41419-017-0082-8 + 29352190 + 5833357 + + + + Bussche, L., and G. R. Van de Walle. Peripheral blood-derived mesenchymal stromal cells promote angiogenesis via paracrine stimulation of vascular endothelial growth factor secretion in the equine model. Stem Cells Transl. 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+ + + 36809392 + + 2023 + 02 + 22 + +
+ + 2191-1991 + + 13 + 1 + + 2023 + Feb + 21 + + + Health economics review + Health Econ Rev + + The intangible costs of overweight and obesity in Germany. + + 14 + + 10.1186/s13561-023-00426-x + + Previous literature documents the direct and indirect economic costs of obesity, yet none has attempted to quantify the intangible costs of obesity. This study focuses on quantifying the intangible costs of one unit body mass index (BMI) increase and being overweight and obese in Germany. + By applying a life satisfaction-based compensation value analysis to 2002-2018 German Socio-Economic Panel Survey data for adults aged 18-65, the intangible costs of overweight and obesity are estimated. We apply individual income as a reference for estimating the value of the loss of subjective well-being due to overweight and obesity. + The intangible costs of overweight and obesity in 2018 amount to 42,450 and 13,853 euros, respectively. A one unit increase in BMI induced a 2553 euros annual well-being loss in the overweight and obese relative to those of normal weight. When extrapolated to the entire country, this figure represents approximately 4.3 billion euros, an intangible cost of obesity similar in magnitude to the direct and indirect costs documented in other studies for Germany. These losses, our analysis reveals, have remained remarkably stable since 2002. + Our results underscore how existing research into obesity's economic toll may underestimate its true costs, and they strongly imply that if obesity interventions took the intangible costs of obesity into account, the economic benefits would be considerably larger. + © 2023. The Author(s). + + + + Meng + Fan + F + + Institute for Health Care & Public Management, University of Hohenheim, 70599, Stuttgart, Germany. + + + + Nie + Peng + P + + Institute for Health Care & Public Management, University of Hohenheim, 70599, Stuttgart, Germany. + + + School of Economics and Finance, Xi'an Jiaotong University, Xi'an, 710061, China. + + + IZA, Bonn, Germany. + + + Health Econometrics and Data Group, University of York, York, UK. + + + + Sousa-Poza + Alfonso + A + + Institute for Health Care & Public Management, University of Hohenheim, 70599, Stuttgart, Germany. alfonso.sousa-poza@uni-hohenheim.de. + + + IZA, Bonn, Germany. alfonso.sousa-poza@uni-hohenheim.de. + + + + eng + + + 202008080268 + China Scholarship Council + + + + 71804142; 72074178 + National Natural Science Foundation of China + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Health Econ Rev + 101583209 + 2191-1991 + + + Germany + Intangible costs + Obesity + Overweight + +
+ + + + 2022 + 09 + 06 + + + 2023 + 02 + 10 + + + 2023 + 2 + 22 + 13 + 45 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809392 + 10.1186/s13561-023-00426-x + 10.1186/s13561-023-00426-x + + + + Mensink GBM, Schienkiewitz A, Haftenberger M, Lampert T, Ziese T, Scheidt-Nave C. Overweight and obesity in Germany. Bundesgesundheitsbl. 2013;56(5–6):786–94. + + 10.1007/s00103-012-1656-3 + + + + OECD/European Observatory on Health Systems and Policies. Germany: Country health profile 2019, State of Health in the EU [Internet]. Paris: OECD Publishing; 2019. (State of health in the EU). https://doi.org/10.1787/36e21650-en . + + + Schienkiewitz A, Mensink GBM, Kuhnert R, Lange C. Übergewicht und Adipositas bei Erwachsenen in Deutschland. J Health Monit. 2017;2(2):21–8. + + + Kahn SE, Hull RL, Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. 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Determinants and consequences of obesity. Am J Public Health. 2016;106(9):1656–62. + + 27459460 + 4981805 + 10.2105/AJPH.2016.303326 + + + + World Health Organization. Global action plan for the prevention and control of noncommunicable diseases 2013–2020 [internet]. World Health Organization; 2013. Available from: https://www.who.int/publications/i/item/9789241506236 . Accessed 14 Oct 2021. + + + Sander B, Bergemann R. Economic burden of obesity and its complications in Germany. Eur J Health Econ. 2003;4(4):248–53. + + 15609192 + 10.1007/s10198-003-0178-1 + + + + Konnopka A, Bödemann M, König HH. Health burden and costs of obesity and overweight in Germany. Eur J Health Econ. 2011;12(4):345–52. + + 20401679 + 10.1007/s10198-010-0242-6 + + + + Lehnert T, Stuhldreher N, Streltchenia P, Riedel-Heller SG, König HH. Sick leave days and costs associated with overweight and obesity in Germany. J Occup Environ Med. 2014;56(1):20–7. + + 24351899 + 10.1097/JOM.0000000000000065 + + + + Lehnert T, Streltchenia P, Konnopka A, Riedel-Heller SG, König HH. Health burden and costs of obesity and overweight in Germany: an update. Eur J Health Econ. 2015;16(9):957–67. + + 25381038 + 10.1007/s10198-014-0645-x + + + + Sonntag D, Ali S, De Bock F. Lifetime indirect cost of childhood overweight and obesity: a decision analytic model. Obesity. 2016;24(1):200–6. + + 26638187 + 10.1002/oby.21323 + + + + Effertz T, Engel S, Verheyen F, Linder R. The costs and consequences of obesity in Germany: a new approach from a prevalence and life-cycle perspective. Eur J Health Econ. 2016;17(9):1141–58. + + 26701837 + 10.1007/s10198-015-0751-4 + + + + Yates N, Teuner CM, Hunger M, Holle R, Stark R, Laxy M, et al. The economic burden of obesity in Germany: results from the population-based KORA studies. Obes Facts. 2016;9(6):397–409. + + 27951530 + 5644792 + 10.1159/000452248 + + + + Katsaiti MS. 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+ + + 36809415 + + 2023 + 02 + 22 + +
+ + 0102-7972 + + 36 + 1 + + 2023 + Feb + 21 + + + Psicologia, reflexao e critica : revista semestral do Departamento de Psicologia da UFRGS + Psicol Reflex Crit + + Validity and reliability of the Chinese version of Threats of Artificial Intelligence Scale (TAI) in Chinese adults. + + 5 + + 10.1186/s41155-023-00247-1 + + With the outbreak of the COVID-19 pandemic, artificial intelligence (AI) has been widely used in fields such as medical treatment, while the threat of artificial intelligence has also received extensive attention. However, this topic has been only limitedly explored in China. To provide a measurement tool for AI threat research in China, this study aimed to examine the validity and reliability of the Threats of Artificial Intelligence Scale (TAI) in two Chinese samples of adults (N1 = 654, N2 = 1483). Results of exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) suggested that the one-factor model of TAI as the best fitting model. Furthermore, the Chinese TAI was significantly related to Positive and Negative Affect Scale and Self-Rating Anxiety Scale, proving good criterion-related validity of the Chinese TAI. In sum, this study suggested the Chinese version of the TAI as a reliable and effective tool in assessing AI threat in the Chinese context. Limitations and future directions are discussed. + © 2023. The Author(s). + + + + Cai + Jie + J + http://orcid.org/0000-0001-9175-3048 + + Department of Psychology, Zhejiang Sci-Tech University, Hangzhou, China. + + + + Xu + Zixuan + Z + http://orcid.org/0000-0001-5504-9854 + + Department of Psychology, Zhejiang Sci-Tech University, Hangzhou, China. + + + + Sun + Xiaoning + X + http://orcid.org/0000-0001-5797-2124 + + Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. + + + + Guo + Xiaojun + X + http://orcid.org/0000-0001-6694-3827 + + School of Education Science, Gannan Normal University, Ganzhou, China. + + + + Fu + Xurong + X + http://orcid.org/0000-0002-0980-4094 + + Institute of Mental Health, Nanjing Xiaozhuang University, Nanjing, China. fuxurongnjnu@163.com. + + + + eng + + + 21062112-Y + Science Foundation of Zhejiang Sci-Tech University(ZSTU) + + + + 21JY49 + the Social Science Planning Program of Jiangxi + + + + XL20203 + the Humanities in Colleges and Universities in Jiangxi Province + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Brazil + Psicol Reflex Crit + 9616730 + 0102-7972 + + + Artificial intelligence + Chinese + Scale development + Threat perceptions + Validity + +
+ + + + 2022 + 07 + 19 + + + 2023 + 01 + 19 + + + 2023 + 2 + 22 + 13 + 46 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809415 + 10.1186/s41155-023-00247-1 + 10.1186/s41155-023-00247-1 + + + + Albuquerque, J., Bittencourt, I. I., Coelho, J. A. P. M., & Silva, A. P. (2017). Does gender stereotype threat in gamified educational environments cause anxiety? An experimental study. Computers and Education,115, 161–170. https://doi.org/10.1016/j.compedu.2017.08.005 + + 10.1016/j.compedu.2017.08.005 + + + + Bahrammirzaee, A. (2010). A comparative survey of artificial intelligence applications in finance: Artificial neural networks, expert system and hybrid intelligent systems. Neural Computing and Applications,19(8), 1165–1195. https://doi.org/10.1007/s00521-010-0362-z + + 10.1007/s00521-010-0362-z + + + + Bar-Haim, Y., Kerem, A., Lamy, D., & Zakay, D. (2010). When time slows down: The influence of threat on time perception in anxiety. Cognition and Emotion,24(2), 255–263. https://doi.org/10.1080/02699930903387603 + + 10.1080/02699930903387603 + + + + Bedyńska, S., & Żołnierczyk-Zreda, D. (2015). Stereotype threat as a determinant of burnout or work engagement. Mediating role of positive and negative emotions. International Journal of Occupational Safety and Ergonomics,21(1), 1–8. https://doi.org/10.1080/10803548.2015.1017939 + + 10.1080/10803548.2015.1017939 + 26327256 + 4536935 + + + + Berggren, N., & Eimer, M. (2021). The role of trait anxiety in attention and memory-related biases to threat: An event-related potential study. Psychophysiology,58(3), 1–10. https://doi.org/10.1111/psyp.13742 + + 10.1111/psyp.13742 + + + + Bilandzic, H., Kalch, A., & Soentgen, J. (2017). Effects of goal framing and emotions on perceived threat and willingness to sacrifice for climate change. Science Communication,39(4), 466–491. https://doi.org/10.1177/1075547017718553 + + 10.1177/1075547017718553 + + + + Bitkina, O. V., Jeong, H., Lee, B. C., Park, J., Park, J., & Kim, H. K. (2020). Perceived trust in artificial intelligence technologies: A preliminary study. Human Factors and Ergonomics in Manufacturing,30(4), 282–290. https://doi.org/10.1002/hfm.20839 + + 10.1002/hfm.20839 + + + + Cai, J., Sun, Q., Mu, Z., & Sun, X. (2022). Psychometric properties of the Chinese version of the trust between People and Automation Scale (TPAS) in Chinese adults. Psicologia: Reflexão e Crítica, 35(15), Advance online publication. https://doi.org/10.1186/s41155-022-00219-x + + + Chen, Y., Li, L., Ybarra, O., & Zhao, Y. (2020). Symbolic threat affects negative self-conscious emotions. Journal of Pacific Rim Psychology,14, 1–8. https://doi.org/10.1017/prp.2020.3 + + 10.1017/prp.2020.3 + + + + Chi, O. H., Jia, S., Li, Y., & Gursoy, D. (2021). Developing a formative scale to measure consumers’ trust toward interaction with artificially intelligent (AI) social robots in service delivery. 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International Journal of Qualitative Methods,9(1), 16–26. https://doi.org/10.1177/160940691000900103 + + 10.1177/160940691000900103 + + + + The General Attitudes towards Artificial Intelligence Scale ( GAAIS ): Confirmatory Validation and Associations with Personality , Corporate Distrust , and General Trust The General Attitudes towards Artificial Intelligence Scale ( GAAIS ): Confirmatory G. International Journal of Human–Computer Interaction, 0(0), 1–18. https://doi.org/10.1080/10447318.2022.2085400 + + + Tambe, P., Cappelli, P., & Yakubovich, V. (2019). Artificial intelligence in human resources management: Challenges and a path forward. California Management Review,61(4), 15–42. https://doi.org/10.1177/0008125619867910 + + 10.1177/0008125619867910 + + + + Tempel, T., & Neumann, R. (2014). Stereotype threat, test anxiety, and mathematics performance. 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D., & William, W. K. (1971). A rating instrument for anxiety disorders. Psychosomatics,12(6), 371–379. https://doi.org/10.1016/S0033-3182(71)71479-0 + + 10.1016/S0033-3182(71)71479-0 + 5172928 + + + + +
+ + + 36809403 + + 2023 + 02 + 22 + +
+ + 1573-9368 + + + 2023 + Feb + 21 + + + Transgenic research + Transgenic Res + + Digestion and utilization of plant-based diets by transgenic pigs secreting β-glucanase, xylanase, and phytase in their salivary glands. + 10.1007/s11248-023-00339-9 + + Novel transgenic (TG) pigs co-expressing three microbial enzymes, β-glucanase, xylanase, and phytase, in their salivary glands were previously generated, which exhibited reduced phosphorus and nitrogen emissions and improved growth performances. In the present study, we attempted to explore the age-related change of the TG enzymic activity, the residual activity of the enzymes in the simulated gastrointestinal tract, and the effect of the transgenes on the digestion of nitrogen and phosphorus content in the fiber-rich, plant-based diets. Results showed that all the three enzymes were stably expressed over the growing and finishing periods in the F2 generation TG pigs. In simulated gastric juice, all the three enzymes exhibited excellent gastrointestinal environment adaptability. The apparent total tract digestibility of phosphorus was increased by 69.05% and 499.64%, while fecal phosphate outputs were decreased by 56.66% and 37.32%, in the TG pigs compared with the wild-type littermates fed with low non-starch polysaccharides diets and high fiber diets, respectively. Over half of available phosphorus and water-soluble phosphorus in fecal phosphorus were reduced. We also found the performance of phosphorus, calcium, and nitrogen retention rates were significantly improved, resulting in faster growth performance in TG pigs. The results indicate that TG pigs can effectively digest the high-fiber diets and exhibit good growth performance compared with wild type pigs. + © 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG. + + + + Yang + Shanxin + S + + College of Animal Science, South China Agricultural University, Guangzhou, 510642, China. + + + + Liu + Tingting + T + + College of Animal Science, South China Agricultural University, Guangzhou, 510642, China. + + + + Mo + Jianxin + J + + Yunfu Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Yunfu, 527400, China. + + + National Engineering Research Center for Breeding Swine Industry, Wens Foodstuff Group Co., Ltd, Yunfu, 527400, China. + + + + Yang + Huaqiang + H + + Yunfu Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Yunfu, 527400, China. + + + College of Animal Science, South China Agricultural University, Guangzhou, 510642, China. + + + National Engineering Research Center for Breeding Swine Industry, Wens Foodstuff Group Co., Ltd, Yunfu, 527400, China. + + + + Wang + Haoqiang + H + + College of Animal Science, South China Agricultural University, Guangzhou, 510642, China. + + + + Huang + Guangyan + G + + College of Animal Science, South China Agricultural University, Guangzhou, 510642, China. + + + + Cai + Gengyuan + G + + Yunfu Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Yunfu, 527400, China. + + + College of Animal Science, South China Agricultural University, Guangzhou, 510642, China. + + + National Engineering Research Center for Breeding Swine Industry, Wens Foodstuff Group Co., Ltd, Yunfu, 527400, China. + + + + Wu + Zhenfang + Z + + Yunfu Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Yunfu, 527400, China. + + + College of Animal Science, South China Agricultural University, Guangzhou, 510642, China. + + + National Engineering Research Center for Breeding Swine Industry, Wens Foodstuff Group Co., Ltd, Yunfu, 527400, China. + + + + Zhang + Xianwei + X + + Yunfu Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Yunfu, 527400, China. zxianw@163.com. + + + National Engineering Research Center for Breeding Swine Industry, Wens Foodstuff Group Co., Ltd, Yunfu, 527400, China. zxianw@163.com. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Netherlands + Transgenic Res + 9209120 + 0962-8819 + + IM + + Nitrogen + Phosphorus + Phytase + Pig + Transgene + +
+ + + + 2022 + 12 + 01 + + + 2023 + 02 + 13 + + + 2023 + 2 + 22 + 13 + 46 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809403 + 10.1007/s11248-023-00339-9 + 10.1007/s11248-023-00339-9 + + + + Allen ND, Cran DG, Barton SC, Hettle S, Reik W, Surani MA (1988) Transgenes as probes for active chromosomal domains in mouse development. Nature 333(6176):852–855. https://doi.org/10.1038/333852a0 + + 10.1038/333852a0 + 3386733 + + + + Allgrove J (2009) Physiology of calcium, phosphate and magnesium. Endocr Dev 16:8–31. https://doi.org/10.1159/000223685 + + 10.1159/000223685 + 19494658 + + + + Al-Shawi R, Kinnaird J, Burke J, Bishop JO (1990) Expression of a foreign gene in a line of transgenic mice is modulated by a chromosomal position effect. 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Biotechnol Lett 36(4):797–803. https://doi.org/10.1007/s10529-013-1413-1 + + 10.1007/s10529-013-1413-1 + 24322768 + + + + Fan MZ, Archbold T (2012) Effects of dietary true digestible calcium to phosphorus ratio on growth performance and efficiency of calcium and phosphorus use in growing pigs fed corn and soybean meal-based diets. J Anim Sci 90(Suppl 4):254–256. https://doi.org/10.2527/jas.54005 + + 10.2527/jas.54005 + 23365347 + + + + Gaillard C, Brossard L, Dourmad JY (2020) Review: improvement of feed and nutrient efficiency in pig production through precision feeding. Anim Feed Sci Technol 268:114611 + + 10.1016/j.anifeedsci.2020.114611 + + + + Golovan S, Wang G, Zhang J, Forsberg CW (2000) Characterization and overproduction of the Escherichia coli appA encoded bifunctional enzyme that exhibits both phytase and acid phosphatase activities. Can J Microbiol 46(1):59–71. https://doi.org/10.1139/cjm-46-1-59 + + 10.1139/cjm-46-1-59 + 10696472 + + + + Golovan SP, Meidinger RG, Ajakaiye A, Cottrill M, Wiederkehr MZ, Barney DJ, Plante C, Pollard JW, Fan MZ, Hayes MA, Laursen J, Hjorth JP, Hacker RR, Phillips JP, Forsberg CW (2001) Pigs expressing salivary phytase produce low-phosphorus manure. Nat Biotechnol 19(8):741–745. https://doi.org/10.1038/90788 + + 10.1038/90788 + 11479566 + + + + Gutzwiller A, Schlegel P, Guggisberg D, Stoll P (2014) Effects of Benzoic acid and dietary calcium: phosphorus ratio on performance and mineral metabolism of weanling pigs. Asian Austral J Anim 27(4):530–536. https://doi.org/10.5713/ajas.2013.13527 + + 10.5713/ajas.2013.13527 + + + + Högberg A, Lindberg JE, Leser T, Wallgren P (2004) Influence of cereal non-starch polysaccharides on ileo-caecal and rectal microbial populations in growing pigs. Acta Vet Scand 45(1–2):87–98. https://doi.org/10.1186/1751-0147-45-87 + + 10.1186/1751-0147-45-87 + 15535089 + 1820981 + + + + Jha R, Berrocoso J (2016) Dietary fiber and protein fermentation in the intestine of swine and their interactive effects on gut health and on the environment: a review. Anim Feed Sci Technol 212:18–26 + + 10.1016/j.anifeedsci.2015.12.002 + + + + Ji F, Casper DP, Brown PK, Spangler DA, Haydon KD, Pettigrew JE (2008) Effects of dietary supplementation of an enzyme blend on the ileal and fecal digestibility of nutrients in growing pigs. J Anim Sci 86(7):1533–1543. https://doi.org/10.2527/jas.2007-0262 + + 10.2527/jas.2007-0262 + 18344302 + + + + Kiarie E, Owusu-Asiedu A, Péron A, Simmins PH, Nyachoti CM (2012) Efficacy of xylanase and β-glucanase blend in mixed grains and grain co-products-based diets for fattening pigs. Livest Sci 148(1–2):129–133 + + 10.1016/j.livsci.2012.05.020 + + + + Luo H, Yang J, Yang P, Li J, Huang H, Shi P, Bai Y, Wang Y, Fan Y, Yao B (2010) Gene cloning and expression of a new acidic family 7 endo-β-1,3–1,4-glucanase from the acidophilic fungus Bispora sp. MEY-1. Appl Microbiol Biotechnol 85(4):1015–1023. https://doi.org/10.1007/s00253-009-2119-0 + + 10.1007/s00253-009-2119-0 + 19590866 + + + + Merchant HA, McConnell EL, Liu F, Ramaswamy C, Kulkarni RP, Basit AW, Murdan S (2011) Assessment of gastrointestinal pH, fluid and lymphoid tissue in the guinea pig, rabbit and pig, and implications for their use in drug development. Eur J Pharm Sci 42(1–2):3–10. https://doi.org/10.1016/j.ejps.2010.09.019 + + 10.1016/j.ejps.2010.09.019 + 20932902 + + + + Metzler-Zebeli BU, Rosenfelder-Kuon P, Brehm H, Eklund M, Mosenthin R (2020) Improved simple T-cannula technique to facilitate surgery and daily skin care of growing pigs. J Anim Sci 98(4):skaa091. https://doi.org/10.1093/jas/skaa091 + + + Mo J, Li G, Huang G, Wang H, Shi J, Zhou R, Cai G, Wu Z, Zhang X (2021) Adaptation of gut microbiome to transgenic pigs secreting beta-glucanase, xylanase, and phytase. Front Genet 12:631071. https://doi.org/10.3389/fgene.2021.631071 + + 10.3389/fgene.2021.631071 + 33747047 + 7971306 + + + + Morgan CA, Whittemore CT (1988) Dietary fibre and nitrogen excretion and retention by pigs. Anim Feed Sci Technol 19(1):185–189 + + 10.1016/0377-8401(88)90066-1 + + + + National Research Council (NRC) (2012) Nutrient requirements of swine. 11th Edition, National Academies Press, Washington DC + + + Ping D, Li D, Cao Y, Lu W, Wang C (2006) Cloning of a gene encoding an acidophilic endo-β-1,4-xylanase obtained from Aspergillus niger CGMCC1067 and constitutive expression in Pichia pastoris. 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Biotechnol Bus. http://en.cnki.com.cn/Article_en/CJFDTotal-SWCY201903011.htm + + + Zhang X, Li Z, Yang H, Liu D, Cai G, Li G, Mo J, Wang D, Zhong C, Wang H, Sun Y, Shi J, Zheng E, Meng F, Zhang M, He X, Zhou R, Zhang J, Huang M, Zhang R, Li N, Fan M, Yang J, Wu Z (2018) Novel transgenic pigs with enhanced growth and reduced environmental impact. Elife 7:e34286. https://doi.org/10.7554/eLife.34286 + + 10.7554/eLife.34286 + 29784082 + 5963925 + + + + +
+ + + 36809413 + + 2023 + 02 + 22 + +
+ + 1573-4994 + + + 2023 + Feb + 21 + + + Journal of fluorescence + J Fluoresc + + Green Constant-wavelength Concurrent Selective Fluorescence Method for Assay of Ibuprofen and Chlorzoxazone in Presence of Chlorzoxazone Degradation Product. + 10.1007/s10895-023-03175-6 + + Lower back pain is a universal dilemma leaving a negative effect on both health and life quality. It was found that a fixed dose combination of chlorzoxazone and ibuprofen gave a higher efficiency than analgesic alone in treatment of acute lower back pain. Based on the significant benefit of that combination, a green, sensitive, rapid, direct, and cost-effective method is created for concurrent determination of ibuprofen and chlorzoxazone in presence of 2-amino para chlorophenol (a synthetic precursor and potential impurity of chlorzoxazone) adopting the synchronous spectrofluorimetric technique. Synchronous spectrofluorimetric technique is adopted to avoid the highly overlapped native spectra of both drugs. The synchronous spectrofluorometric method was applied at Δλ = 50 nm, ibuprofen was measured at 227 nm while chlorzoxazone was measured at 282 nm with no hindering from one to another. The various experimental variables affecting the performance of the suggested technique were explored and adjusted. The suggested technique showed good linearity from 0.02 to 0.6 and 0.1 to 5.0 µg/mL for ibuprofen and chlorzoxazone, respectively. The produced detection limits were 0.27 × 10-3 and 0.03, while the quantitation limits were 0.82 × 10-3 and 0.09 µg/mL for ibuprofen and chlorzoxazone, respectively. The suggested approach was successfully applied for the analysis of the studied drugs in the synthetic mixture, different pharmaceutical preparations, and spiked human plasma. The suggested technique was validated with respect to the International Council of Harmonization (ICH) recommendations. The suggested technique was found to be simpler and greener with lower cost compared to the earlier reported methods which required complicated techniques, longer time of analysis, and less safe solvents and reagents. Green profile assessment for the developed method compared with the reported spectrofluorometric method was performed using four assessment tools. These tools confirmed that the recommended technique attained the most possible green parameters, so it could be used as a greener option in routine quality control for analyzing the two drugs in genuine form and pharmaceutical preparations. + © 2023. The Author(s). + + + + Abdallah + Nora A + NA + + Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt. noraabdallah91@mans.edu.eg. + + + + Fathy + Mona E + ME + + Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt. + + + + Tolba + Manar M + MM + + Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt. + + + + El-Brashy + Amina M + AM + + Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt. + + + + Ibrahim + Fawzia A + FA + + Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Netherlands + J Fluoresc + 9201341 + 1053-0509 + + IM + + 2-amino 4-chlorophenol + Chlorzoxazone + Chlorzoxazone impurity + Greenness assessment tools + Ibuprofen + Pharmaceutical preparations and biological fluids + Spectrofluorimetry + +
+ + + + 2023 + 01 + 28 + + + 2023 + 02 + 11 + + + 2023 + 2 + 22 + 13 + 46 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809413 + 10.1007/s10895-023-03175-6 + 10.1007/s10895-023-03175-6 + + + + Skoog DA, Holler FJ, Crouch SR (2017) Principles of instrumental analysis. Cengage Learn + + + Abu-hassan AA, Ali R, Derayea SM (2020) One-pot micellar augmented native fluorescence for facile fluorimetric assay of dapoxetine hydrochloride in biological plasma and tablets. Spectrochim Acta Part A Mol Biomol Spectrosc 239:118512 + + 10.1016/j.saa.2020.118512 + + + + Abu-hassan AA, Omar MA, Derayea SM (2020) New approach for stability study and determination of fluvoxamine in raw materials and pharmaceuticals through condensation with 2,2-dihydroxyindane-1,3-dione. Luminescence 35:934–940 + + 10.1002/bio.3807 + 32314859 + + + + Abu-hassan AA, Omar MA, Derayea SM (2020) Use of acetylacetone for nano-level assay of fluvoxamine maleate in pure form and pharmaceutical formulation. Luminescence 35:1360–1365 + + 10.1002/bio.3898 + 32519373 + + + + Abu-hassan AA, El Hamd MA, El-Maghrabey MH, Mahdi WA, Alshehri S, Shaaban Mohammed B (2023) Application of isoindole fluorophore formation for determination of linagliptin in the sole and co-formulated tablets: Application for plasma assay and content uniformity testing. Spectrochim Acta Part A Mol Biomol Spectrosc 291:122390 + + 10.1016/j.saa.2023.122390 + + + + Abu-hassan AA, Ali R, Derayea SM (2020) One-pot reaction for determination of Asenapine maleate through facile complex formation with xanthine based dye: Application to content uniformity test. 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+ + + 36809399 + + 2023 + 02 + 22 + +
+ + 1540-9538 + + 220 + 5 + + 2023 + May + 01 + + + The Journal of experimental medicine + J Exp Med + + Retinoic acid signaling during priming licenses intestinal CD103+ CD8 TRM cell differentiation. + e20210923 + 10.1084/jem.20210923 + + CD8 tissue-resident memory T (TRM) cells provide frontline protection at barrier tissues; however, mechanisms regulating TRM cell development are not completely understood. Priming dictates the migration of effector T cells to the tissue, while factors in the tissue induce in situ TRM cell differentiation. Whether priming also regulates in situ TRM cell differentiation uncoupled from migration is unclear. Here, we demonstrate that T cell priming in the mesenteric lymph nodes (MLN) regulates CD103+ TRM cell differentiation in the intestine. In contrast, T cells primed in the spleen were impaired in the ability to differentiate into CD103+ TRM cells after entry into the intestine. MLN priming initiated a CD103+ TRM cell gene signature and licensed rapid CD103+ TRM cell differentiation in response to factors in the intestine. Licensing was regulated by retinoic acid signaling and primarily driven by factors other than CCR9 expression and CCR9-mediated gut homing. Thus, the MLN is specialized to promote intestinal CD103+ CD8 TRM cell development by licensing in situ differentiation. + © 2023 Qiu et al. + + + + Qiu + Zhijuan + Z + 0000-0003-3097-7181 + + Department of Microbiology and Immunology, Center for Infectious Diseases, Renaissance School of Medicine, Stony Brook University , Stony Brook, NY, USA. + https://ror.org/05qghxh33 + + + + Khairallah + Camille + C + 0000-0003-2687-9634 + + Department of Microbiology and Immunology, Center for Infectious Diseases, Renaissance School of Medicine, Stony Brook University , Stony Brook, NY, USA. + https://ror.org/05qghxh33 + + + + Chu + Timothy H + TH + 0000-0003-3822-3253 + + Department of Microbiology and Immunology, Center for Infectious Diseases, Renaissance School of Medicine, Stony Brook University , Stony Brook, NY, USA. + https://ror.org/05qghxh33 + + + + Imperato + Jessica N + JN + 0000-0003-1708-5680 + + Department of Microbiology and Immunology, Center for Infectious Diseases, Renaissance School of Medicine, Stony Brook University , Stony Brook, NY, USA. + https://ror.org/05qghxh33 + + + + Lei + Xinyuan + X + 0000-0001-5049-6188 + + Department of Microbiology and Immunology, Center for Infectious Diseases, Renaissance School of Medicine, Stony Brook University , Stony Brook, NY, USA. + https://ror.org/05qghxh33 + + + + Romanov + Galina + G + 0000-0001-8160-636X + + Department of Microbiology and Immunology, Center for Infectious Diseases, Renaissance School of Medicine, Stony Brook University , Stony Brook, NY, USA. + https://ror.org/05qghxh33 + + + + Atakilit + Amha + A + 0000-0002-8586-7230 + + Lung Biology Center, Department of Medicine, University of California, San Francisco , San Francisco, CA, USA. + https://ror.org/043mz5j54 + + + + Puddington + Lynn + L + 0000-0002-5355-9647 + + Department of Immunology, University of Connecticut Health , Farmington, CT, USA. + + + + Sheridan + Brian S + BS + 0000-0002-3299-5888 + + Department of Microbiology and Immunology, Center for Infectious Diseases, Renaissance School of Medicine, Stony Brook University , Stony Brook, NY, USA. + https://ror.org/05qghxh33 + + + + eng + + + K12GM102778 + NH + NIH HHS + United States + + + Stony Brook University + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + J Exp Med + 2985109R + 0022-1007 + + IM +
+ + + + 2021 + 04 + 29 + + + 2022 + 12 + 02 + + + 2023 + 02 + 01 + + + 2023 + 2 + 22 + 13 + 46 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809399 + 213882 + 10.1084/jem.20210923 + + +
+ + + 36809404 + + 2023 + 02 + 22 + +
+ + 1432-0851 + + + 2023 + Feb + 21 + + + Cancer immunology, immunotherapy : CII + Cancer Immunol Immunother + + Correction to: TIGIT blockade enhances tumor response to radiotherapy via a CD103 + dendritic cell-dependent mechanism. + 10.1007/s00262-023-03402-w + + + Zhao + Kaikai + K + + Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China. + + + Department of Radiation Oncology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, China. + + + + Jiang + Liyang + L + + Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China. + + + + Si + Youjiao + Y + + Department of Radiology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China. + + + Department of Radiology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, China. + + + + Zhou + Shujie + S + + Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China. + + + Cheeloo College of Medicine, Shandong University, Jinan, China. + + + + Huang + Zhaoqin + Z + + Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China. devin813@163.com. + + + + Meng + Xiangjiao + X + + Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China. mengxiangjiao@126.com. + + + + eng + + Published Erratum + + + 2023 + 02 + 21 + +
+ + Germany + Cancer Immunol Immunother + 8605732 + 0340-7004 + + IM + + + Cancer Immunol Immunother. 2023 Jan;72(1):193-209 + 35794399 + + +
+ + + + 2023 + 2 + 22 + 13 + 46 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809404 + 10.1007/s00262-023-03402-w + 10.1007/s00262-023-03402-w + + +
+ + + 36809411 + + 2023 + 02 + 22 + +
+ + 1573-4994 + + + 2023 + Feb + 21 + + + Journal of fluorescence + J Fluoresc + + Benzil Bis-Hydrazone Based Fluorescence 'Turn-on' Sensor for Highly Sensitive and Selective Detection of Zn(II) Ions. + 10.1007/s10895-023-03178-3 + + In this study, a novel Benzil Bis-Hydrazone (BBH) sensor with two C = N-N = C moieties was designed and synthesized based on the condensation reaction between benzil-dihydrazone (b) and cinnamaldehyde. The BBH probe in dimethylsulfoxide showed extremely weak fluorescence. However, the same solution exhibited an intensive fluorescence enhancement (152-fold) with the introduction of Zn(II) ions. In contrast, no or negligible fluorescence changes were observed when other ions were added. The fluorogenic behavior of BBH towards the examined cations indicated an excellent selectivity of the BBH sensor for Zn(II) cations without any interference from other cations like Fe(II), Mg(II), Cu(II), Co(II), Mn(II), Cr(III), Hg(II), Sn(II), Al(I), La(III), Ca(II), Ba(II), Na(I), K(I), and especially Cd(II). Moreover, the UV-vis spectrophotometric titrations revealed that a 1:1 stoichiometric complex BBH-Zn(II) was formed during the Zn(II) sensing and the binding constant value for this complex was calculated to be equal to 106.8. Further, in order to show the affinity of the BBH sensor for Zn(II) cations, it was deemed necessary to determine the limit of detection (LOD) which was found to equal to 2.5 10-4 M. + © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. + + + + Hamzi + I + I + http://orcid.org/0000-0002-5394-6145 + + Laboratoire de Catalyse Et Synthèse en Chimie Organique, Faculté Des Sciences, Université de Tlemcen, B.P.119, 13000, Tlemcen, Algeria. imenehamzi13@yahoo.com. + + + Faculté de Médecine, Université de Tlemcen, 12 B P 123 Hamri Ahmed, 13000, Tlemcen, Algeria. imenehamzi13@yahoo.com. + + + + Touati + Y + Y + + Laboratoire de Catalyse Et Synthèse en Chimie Organique, Faculté Des Sciences, Université de Tlemcen, B.P.119, 13000, Tlemcen, Algeria. + + + + Mostefa-Kara + B + B + + Laboratoire de Catalyse Et Synthèse en Chimie Organique, Faculté Des Sciences, Université de Tlemcen, B.P.119, 13000, Tlemcen, Algeria. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Netherlands + J Fluoresc + 9201341 + 1053-0509 + + IM + + Bis-hydrazone + Chemosensor + Fluorescence + Zn(II) ions + +
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+ + + 36809405 + + 2023 + 02 + 22 + +
+ + 1432-0851 + + + 2023 + Feb + 21 + + + Cancer immunology, immunotherapy : CII + Cancer Immunol Immunother + + Correction to: Determinants of activity and efficacy of anti-PD1/PD-L1 therapy in patients with advanced solid tumors recruited in a clinical trials unit: a longitudinal prospective biomarker-based study. + 10.1007/s00262-023-03396-5 + + + García-Corbacho + Javier + J + + Medical Oncology Department, Hospital Clinic of Barcelona, Barcelona, Spain. + + + Medical Oncology Department (UGCI), Virgen de La Victoria and Regional University Hospital / IBIMA, Málaga, Spain. + + + + Indacochea + Alberto + A + + Medical Oncology Department, Hospital Clinic of Barcelona, Barcelona, Spain. + + + Medical Oncology Department, Hospital General of Granollers, Barcelona, Spain. + + + + González Navarro + Azucena E + AE + + Immunology Department, Hospital Clinic of Barcelona, Barcelona, Spain. + + + + Victoria + Iván + I + + Medical Oncology Department, Hospital Clinic of Barcelona, Barcelona, Spain. + + + + Moreno + Débora + D + + Medical Oncology Department, Hospital Clinic of Barcelona, Barcelona, Spain. + + + + Pesántez + David + D + + Medical Oncology Department, Hospital Clinic of Barcelona, Barcelona, Spain. + + + + Angelats + Laura + L + + Medical Oncology Department, Hospital Clinic of Barcelona, Barcelona, Spain. + + + Translational Genomics and Targeted Therapies in Solid Tumours Group, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain. + + + + Modrego-Sanchez + Andrea + A + + Medical Oncology Department, University Hospital, 12 de Octubre, Madrid, Spain. + + + + Sanfeliu + Esther + E + + Translational Genomics and Targeted Therapies in Solid Tumours Group, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain. + + + Pathology Department, Diagnostic Biomedical Center, Hospital Clinic of Barcelona, Barcelona, Spain. + + + + Castillo + Oleguer + O + + Translational Genomics and Targeted Therapies in Solid Tumours Group, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain. + + + + Blasco + Paula + P + + Translational Genomics and Targeted Therapies in Solid Tumours Group, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain. + + + + Mezquita + Laura + L + + Medical Oncology Department, Hospital Clinic of Barcelona, Barcelona, Spain. + + + Translational Genomics and Targeted Therapies in Solid Tumours Group, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain. + + + Departament de Medicina, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, c. Casanova, 143, 08036, Barcelona, Spain. + + + + Viñolas + Nuria + N + + Medical Oncology Department, Hospital Clinic of Barcelona, Barcelona, Spain. + + + Translational Genomics and Targeted Therapies in Solid Tumours Group, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain. + + + + Nogué + Miquel + M + + Medical Oncology Department, Hospital General of Granollers, Barcelona, Spain. + + + + Galván + Patricia + P + + Translational Genomics and Targeted Therapies in Solid Tumours Group, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain. + + + + Adamo + Barbara + B + + Medical Oncology Department, Hospital Clinic of Barcelona, Barcelona, Spain. + + + Translational Genomics and Targeted Therapies in Solid Tumours Group, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain. + + + + Basté + Neus + N + + Medical Oncology Department, Hospital Clinic of Barcelona, Barcelona, Spain. + + + Translational Genomics and Targeted Therapies in Solid Tumours Group, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain. + + + + Sauri + Tamara + T + + Medical Oncology Department, Hospital Clinic of Barcelona, Barcelona, Spain. + + + Translational Genomics and Targeted Therapies in Solid Tumours Group, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain. + + + + Juan + Manel + M + + Immunology Department, Hospital Clinic of Barcelona, Barcelona, Spain. + + + + Prat + Aleix + A + + Medical Oncology Department, Hospital Clinic of Barcelona, Barcelona, Spain. alprat@clinic.cat. + + + Translational Genomics and Targeted Therapies in Solid Tumours Group, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain. alprat@clinic.cat. + + + Departament de Medicina, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, c. Casanova, 143, 08036, Barcelona, Spain. alprat@clinic.cat. + + + + Schettini + Francesco + F + + Medical Oncology Department, Hospital Clinic of Barcelona, Barcelona, Spain. schettini@clinic.cat. + + + Translational Genomics and Targeted Therapies in Solid Tumours Group, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain. schettini@clinic.cat. + + + Departament de Medicina, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, c. Casanova, 143, 08036, Barcelona, Spain. schettini@clinic.cat. + + + + eng + + Published Erratum + + + 2023 + 02 + 21 + +
+ + Germany + Cancer Immunol Immunother + 8605732 + 0340-7004 + + IM + + + Cancer Immunol Immunother. 2023 Jan 10;: + 36625938 + + +
+ + + + 2023 + 2 + 22 + 13 + 46 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809405 + 10.1007/s00262-023-03396-5 + 10.1007/s00262-023-03396-5 + + +
+ + + 36809401 + + 2023 + 02 + 22 + +
+ + 1618-0860 + + + 2023 + Feb + 21 + + + Journal of plant research + J Plant Res + + Biochemical responses in leaf tissues of alkaloid producing Psychotria brachyceras under multiple stresses. + 10.1007/s10265-023-01441-z + + Under natural conditions plants are generally subjected to complex scenarios of combined or sequential environmental stresses. Among the various components of plant biochemistry modulated by abiotic variables, a pivotal role is played by antioxidant systems, including specialized metabolites and their interaction with central pathways. To help address this knowledge gap, a comparative analysis of metabolic changes in leaf tissues of the alkaloid accumulating plant Psychotria brachyceras Müll Arg. under individual, sequential, and combined stress conditions was carried out. Osmotic and heat stresses were evaluated. Protective systems (accumulation of the major antioxidant alkaloid brachycerine, proline, carotenoids, total soluble protein, and activity of the enzymes ascorbate peroxidase and superoxide dismutase) were measured in conjunction with stress indicators (total chlorophyll, ChA/ChB ratio, lipid peroxidation, H2O2 content and electrolyte leakage). Metabolic responses had a complex profile in sequential and combined stresses compared to single ones, being also modified over time. Different stress application schemes affected alkaloid accumulation in distinct ways, exhibiting similar profile to proline and carotenoids, constituting a complementary triad of antioxidants. These complementary non-enzymatic antioxidant systems appeared to be essential for mitigating stress damage and re-establishing cellular homeostasis. The data herein provides clues that may aid the development of a key component framework of stress responses and their appropriate balance to modulate tolerance and yield of target specialized metabolites. + © 2023. The Author(s) under exclusive licence to The Botanical Society of Japan. + + + + De Palma + Nicolás + N + http://orcid.org/0000-0001-7514-7240 + + Plant Physiology Laboratory, Department of Botany, Biosciences Institute, Federal University of Rio Grande do Sul, CP 15005, Porto Alegre, RS, 91501-970, Brazil. + + + + Yendo + Anna Carolina Alves + ACA + http://orcid.org/0000-0002-3252-324X + + Plant Physiology Laboratory, Department of Botany, Biosciences Institute, Federal University of Rio Grande do Sul, CP 15005, Porto Alegre, RS, 91501-970, Brazil. + + + Plant Physiology Laboratory, Center for Biotechnology, Federal University of Rio Grande do Sul, CP 15005, Porto Alegre, RS, 91501-970, Brazil. + + + + Vilasboa + Johnatan + J + http://orcid.org/0000-0002-0674-7661 + + Plant Physiology Laboratory, Department of Botany, Biosciences Institute, Federal University of Rio Grande do Sul, CP 15005, Porto Alegre, RS, 91501-970, Brazil. + + + + Chacon + Daisy Sotero + DS + + Pharmacognosy Laboratory, Department of Pharmacy, Federal University of Rio Grande do Norte, CP 59000, Natal, RN, 59012-570, Brazil. + + + + Fett-Neto + Arthur Germano + AG + http://orcid.org/0000-0001-5477-2610 + + Plant Physiology Laboratory, Department of Botany, Biosciences Institute, Federal University of Rio Grande do Sul, CP 15005, Porto Alegre, RS, 91501-970, Brazil. fett.neto@ufrgs.br. + + + Plant Physiology Laboratory, Center for Biotechnology, Federal University of Rio Grande do Sul, CP 15005, Porto Alegre, RS, 91501-970, Brazil. fett.neto@ufrgs.br. + + + + eng + + + Finance Code 01 + Coordenação de Aperfeiçoamento de Pessoal de Nível Superior + + + + Project 310775/2021-3 + Conselho Nacional de Desenvolvimento Científico e Tecnológico + + + + 19/2551-0001709-0 + Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Japan + J Plant Res + 9887853 + 0918-9440 + + IM + + Abiotic stress + Combined stress + Heat stress + Osmotic stress + Psychotria + Sequential stress + +
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+ + + 36809407 + + 2023 + 02 + 22 + +
+ + 1432-069X + + + 2023 + Feb + 21 + + + Archives of dermatological research + Arch Dermatol Res + + The relationship of quality of life and acne severity with chronotype and insomnia in patients with acne vulgaris. + 10.1007/s00403-023-02569-7 + + This study aimed to examine the relationship between acne severity and quality of life, insomnia, and chronotype. This study included 151 patients diagnosed with acne vulgaris, aged 18-30 years. A sociodemographic data form was completed by the clinician, and acne severity was evaluated using the Global Acne Grading System (GAGS). The Visual Analogue Scale (VAS), Acne Quality of Life Scale (AQLS), Hospital Anxiety Depression Scale (HADS), Insomnia Severity Index (ISI), and Morningness-Eveningness Questionnaire (MEQ) were completed by the participants. There was a significant difference between the MEQ scores of the participants who were divided into three groups according to the severity of global acne, as mild, moderate, and severe. In the post hoc analysis, the MEQ scores of the patients with mild acne were determined to be significantly higher than the scores of the patients with moderate and severe acne. A statistically significant negative correlation was observed between the GAGS scores and the MEQ scores. In addition, a statistically significant positive correlation was found between the participants' ISI scores and AQLS scores. Considering the variables related to chronotype and sleep in the treatment planning for patients with acne vulgaris may be appropriate within the scope of integrative treatment. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Güler + Dilara + D + + Department of Dermatology, Afyonkarahisar Health Sciences University, Afyonkarahisar, 03030, Turkey. dr.dilaraguler@gmail.com. + + + Department of Dermatology, Konya Meram State Hospital, Konya, Turkey. dr.dilaraguler@gmail.com. + + + + Soylu + Seçil + S + + Department of Dermatology, Afyonkarahisar Health Sciences University, Afyonkarahisar, 03030, Turkey. + + + + Güler + Hasan Ali + HA + + Department of Child and Adolescent Psychiatry, Faculty of Medicine, Selcuk University, Konya, Turkey. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Arch Dermatol Res + 8000462 + 0340-3696 + + IM + + Acne + Chronotype + Insomnia + Quality of life + +
+ + + + 2022 + 11 + 14 + + + 2023 + 02 + 07 + + + 2023 + 01 + 17 + + + 2023 + 2 + 22 + 13 + 46 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809407 + 10.1007/s00403-023-02569-7 + 10.1007/s00403-023-02569-7 + + + + Williams HC, Dellavalle RP, Garner S (2001) Acne vulgaris. Lancet 379:361–372 + + 10.1016/S0140-6736(11)60321-8 + + + + Schäfer T, Nienhaus A, Vieluf D et al (2001) Epidemiology of acne in the general population: the risk of smoking. Br J Dermatol 145:100–104 + + 10.1046/j.1365-2133.2001.04290.x + 11453915 + + + + Güngör E (2012) Akne. Turkish J Dermatol 6:138–149 + + + Kligman A (1991) Postadolescent acne in women. Cutis 48:75–77 + + 1831118 + + + + Koo JY, Smith LL (1991) Psychologic aspects of acne. Pediatr Dermatol 8:185–188 + + 10.1111/j.1525-1470.1991.tb00856.x + 1836060 + + + + Erturan İ, Aktepe E, Kocaman O et al (2014) Akneli ergenlerin yaşam kalitesi, yalnızlık ve yaşam doyumu düzeylerinin değerlendirilmesi. TÜRKDERM-Deri Hastalıkları ve Frengi Arşivi 48:172–176 + + + Kerkhof GA (1985) Inter-individual differences in the human circadian system: a review. Biol Psychol 20:83–112 + + 10.1016/0301-0511(85)90019-5 + 3888298 + + + + Lacoste V, Wetterberg L (1993) Individual variations of rhythms in morning and evening types with special emphasis on seasonal differences. In: Wetterberg L (ed) Light and biological rhythms in man. Pergamon Press, Oxford, pp 287–304 + + 10.1016/B978-0-08-042279-4.50024-8 + + + + Mecacci L, Rocchetti G (1998) Morning and evening types: stress-related personality aspects. Pers Individ Differ 25:537–542 + + 10.1016/S0191-8869(98)00087-7 + + + + Saçmacı H, Gürel G (2019) Sleep disorders in patients with psoriasis: a cross-sectional study using non-polysomnographical methods. Sleep Breath 23:893–898 + + 10.1007/s11325-019-01820-8 + 30859369 + + + + Selvi Y, Aydin A, Boysan M et al (2010) Associations between chronotype, sleep quality, suicidality, and depressive symptoms in patients with major depression and healthy controls. Chronobiol Int 27:1813–1828 + + 10.3109/07420528.2010.516380 + 20969525 + + + + Bilgili SG, Aydin A, Selvi Y et al (2013) The role of patient chronotypes on circadian pattern of chronic pruritus: a latent growth modeling analysis. Biol Rhythm Res 44:807–814 + + 10.1080/09291016.2012.756275 + + + + Henry A, Kyle S, Chisholm A et al (2017) A cross-sectional survey of the nature and correlates of sleep disturbance in people with psoriasis. Br J Dermatol 177:1052–1059 + + 10.1111/bjd.15469 + 28314054 + + + + Doshi A, Zaheer A, Stiller MJ (1997) A comparison of current acne grading systems and proposal of a novel system. Int J Dermatol 36:416–418 + + 10.1046/j.1365-4362.1997.00099.x + 9248884 + + + + Sadick NS, Laver Z, Laver L (2010) Treatment of mild-to-moderate acne vulgaris using a combined light and heat energy device: home-use clinical study. J Cosmet Laser Ther 12:276–283 + + 10.3109/14764172.2010.538409 + 21142737 + + + + Gupta MA, Johnson AM, Gupta AK (1998) The development of an Acne Quality of Life scale: reliability, validity, and relation to subjective acne severity in mild to moderate acne vulgaris. Acta Derm-Venereol 78:451–456 + + 10.1080/000155598442773 + 9833047 + + + + Demirçay Z, Şenol A, Seçkin D, Demir F (2006) Reliability of Turkish version of acne quality of life scale in patients with acne vulgaris. TURKDERM-Turk Arch Dermatol Venereol 40:94–97 + + + Zigmond AS, Snaith RP (1983) The hospital anxiety and depression scale. Acta Psychiatr Scand 67:361–370 + + 10.1111/j.1600-0447.1983.tb09716.x + 6880820 + + + + Aydemir Ö, Guvenir T, Kuey L, Kultur S (1997) Validity and reliability of Turkish version of hospital anxiety and depression scale. Turk Psikiyatri Derg 8:280–287 + + + Boysan M, Güleç M, Besiroglu L, Kalafat T (2010) Uykusuzluk Siddeti Indeksi’nin Türk örneklemindeki psikometrik özellikleri. Anadolu Psikiyatri Dergisi 11:248–252 + + + Agargun MY, Cilli AS, Boysan M et al (2007) Turkish version of morningness-eveningness questionnaire (MEQ). Sleep Hypn 9:16–23 + + + Viticchi G, Falsetti L, Paolucci M et al (2019) Influence of chronotype on migraine characteristics. Neurol Sci 40:1841–1848 + + 10.1007/s10072-019-03886-4 + 31044321 + + + + Chrobak AA, Nowakowski J, Zwolińska-Wcisło M et al (2018) Associations between chronotype, sleep disturbances and seasonality with fatigue and inflammatory bowel disease symptoms. Chronobiol Int 35:1142–1152 + + 29737879 + + + + Türkoğlu G, Selvi Y (2020) The relationship between chronotype, sleep disturbance, severity of fibromyalgia, and quality of life in patients with fibromyalgia. Chronobiol Int 37:68–81 + + 10.1080/07420528.2019.1684314 + 31687843 + + + + Kandeger A, Egilmez U, Sayin AA, Selvi Y (2018) The relationship between night eating symptoms and disordered eating attitudes via insomnia and chronotype differences. Psychiatry Res 268:354–357 + + 10.1016/j.psychres.2018.08.003 + 30098543 + + + + Yazdi Z, Sadeghniiat-Haghighi K, Javadi ARHS, Rikhtegar G (2014) Sleep quality and insomnia in nurses with different circadian chronotypes: morningness and eveningness orientation. Work 47:561–567 + + 10.3233/WOR-131664 + 23823210 + + + + Schrom KP, Ahsanuddin S, Baechtold M et al (2019) Acne severity and sleep quality in adults. Clocks Sleep 1:510–516 + + 10.3390/clockssleep1040039 + 33089183 + 7445853 + + + + Martin A, Lookingbill D, Botek A et al (2001) Health-related quality of life among patients with facial acne− assessment of a new acne-specific questionnaire. Clin Exp Dermatol 26:380–385 + + 10.1046/j.1365-2230.2001.00839.x + 11488820 + + + + Watson NF, Badr MS, Belenky G et al (2015) Recommended amount of sleep for a healthy adult: a joint consensus statement of the American Academy of Sleep Medicine and Sleep Research Society. Sleep 38:843–844 + + 26039963 + 4434546 + + + + +
+ + + 36809406 + + 2023 + 02 + 22 + +
+ + 1432-069X + + + 2023 + Feb + 21 + + + Archives of dermatological research + Arch Dermatol Res + + Fractional CO2 laser in the treatment of nail psoriasis: how can it help? + 10.1007/s00403-023-02574-w + + Treating nail psoriasis is often a time-consuming challenge with an unsecure outcome. Response to the treatment is variable and relapses are common. Systemic treatments have multiple systemic side effects and lack of the patient compliance makes intra-lesional therapies not the best choice for treatment of nail psoriasis. We aimed to evaluate and compare the efficacy and side effects of methotrexate versus calcipotriol plus betamethasone two-compound formula when applied topically to psoriatic nails after fractional CO2 laser. This comparative pilot study included 20 patients with nail psoriasis. One side was treated with fractional CO2 laser followed by the application of topical methotrexate (Group A) and the other side with fractional CO2 laser followed by topical (Calcipotriol 0.05 mg/gm + Betamethasone 0.5 mg/gm) (Group B). 4 sessions were done, once every 2 weeks. There was a high statistical significant decrease in total NAPSI score in group A at 1(P = 0.000) and 2 months (P = 0.000). There was a high statistical significant decrease in total NAPSI score in group B at 1(P = 0.001) and 2 months (P = 0.001). There was no statistical significant difference regarding total NAPSI score between both group A and B at 0 (P = 0.271), 1(P = 0.513) and 2 months (P = 0.647). Combined fractional CO2 laser with either topical MTX or topical betamethasone plus calcipotriol two-compound formula is effective treatment for nail psoriasis. + © 2023. The Author(s). + + + + Afify + Ahmed Abdelfattah + AA + + Dermatology, Venereology and Andrology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. dr.ahmed_abdelfattah1982@yahoo.com. + + + + Shaheen + Maha Adel + MA + + Dermatology, Venereology and Andrology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. + + + + El-Banna + Mahmoud Gamal + MG + + Dermatology, Venereology and Andrology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Arch Dermatol Res + 8000462 + 0340-3696 + + IM + + Fractional + How-Help + Laser + Nail + Psoriasis + +
+ + + + 2022 + 11 + 29 + + + 2023 + 02 + 07 + + + 2023 + 02 + 04 + + + 2023 + 2 + 22 + 13 + 46 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809406 + 10.1007/s00403-023-02574-w + 10.1007/s00403-023-02574-w + + + + Schlager JG, Rosumeck S, Werner RN, Jacobs A, Schmitt J, Schlager C, Nast A (2017) Topical treatments for scalp psoriasis: summary of a cochrane systematic review. Br J Dermatol 176(3):604–614 + + 10.1111/bjd.14811 + 27312814 + + + + Maranda EL, Nguyen AH, Lim VM, Hafeez F, Jimenez JJ (2016) Laser and light therapies for the treatment of nail psoriasis. J Eur Acad Dermatol Venerol 30(8):1278–1284 + + 10.1111/jdv.13678 + + + + Afshar A, Tabrizi A (2017) Nail psoriasis triggered by the reconstruction of syndactyly. Arch Bone Jt Surg 5(3):193–195 + + 28656168 + 5466865 + + + + Lorizzo M (2015) Tips to treat the 5 most common nail disorders. Dermatol clin 33(2):175–183 + + 10.1016/j.det.2014.12.001 + + + + Omi T, Numano K (2014) The role of the CO2 laser and fractional CO2 laser in dermatology. Laser Ther 23(1):49–60 + + 10.5978/islsm.14-RE-01 + 24771971 + 3999431 + + + + Haustein UF, Rytter M (2000) Methotrexate in psoriasis: 26 years’ experience with low-dose long-term treatment. J Eur Acad Dermatol Venereol 14(5):382–388 + + 10.1046/j.1468-3083.2000.00058.x + 11305380 + + + + Grover C, Daulatabad D, Singal A (2017) Role of nail bed methotrexate injections in isolated nail psoriasis: conventional drug via an unconventional route. Clin Exp Dermatol 42(4):420–423 + + 10.1111/ced.13087 + 28397295 + + + + Nguyen HX, Banga AK (2018) Effect of ablative laser on in vitro transungual delivery. Int J Pharm 544(2):402–414 + + 10.1016/j.ijpharm.2017.09.048 + 28951347 + + + + Alakad R, Nassar A, Atef H, Eldeeb F (2022) Fractional CO2 laser-assisted delivery versus intralesional injection of methotrexate in psoriatic nails. Dermatol Surg 48(5):539–544 + + 10.1097/DSS.0000000000003418 + 35333217 + + + + Rigopoulos D, Gregoriou S, Daniel Iii CR, Belyayeva H, Larios G, Verra P, Stamou C, Kontochristopoulos G, Avgerinou G, Katsambas A (2009) Treatment of nail psoriasis with a two-compound formulation of calcipotriol plus betamethasone dipropionate ointment. Dermatology 218(4):338–341 + + 10.1159/000202179 + 19212110 + + + + Emam A, Fathy G, Hathoot H (2014) A randomized placebo-controlled pilot study to assess the efficacy of botulinum toxin A in reducing sebum production in oily skin. Asian Acad Res J Multidiscil 23(1):621–639 + + + Ventura A, Mazzeo M, Gaziano R, Galluzzo M, Bianchi L, Campione E (2017) New insight into the pathogenesis of nail psoriasis and overview of treatment strategies. Drug Des Devel Ther 11:2527–2535 + + 10.2147/DDDT.S136986 + 28919705 + 5587086 + + + + Tan ES, Chong WS, Tey HL (2012) Nail psoriasis: a review. Am J Clin Dermatol 13(6):375–388 + + 10.2165/11597000-000000000-00000 + 22784035 + + + + Oram Y, Akkaya AD (2013) Treatment of nail psoriasis: common concepts and new trends. Dermatol Res Pract 2013:180496 + + 10.1155/2013/180496 + 23762032 + 3666424 + + + + Pasch MC (2016) Nail psoriasis: a review of treatment options. Drugs 76(6):675–705 + + 10.1007/s40265-016-0564-5 + 27041288 + 4833799 + + + + Haneke E (2017) Nail psoriasis: clinical features, pathogenesis, differential diagnoses, and management. Psoriasis (Auckl) 7:51–63 + + 29387608 + + + + Nassar A, Elakad R, Saeed HA (2021) Laser therapy of nail psoriasis. Eur J Mol Clin Med 8(4):852–856 + + + +
+ + + 36809412 + + 2023 + 02 + 22 + +
+ + 1573-4994 + + + 2023 + Feb + 21 + + + Journal of fluorescence + J Fluoresc + + Optical Sensing Capability Evaluation for Methylammonium Based Perovskites for Explosive. + 10.1007/s10895-023-03174-7 + + Here, we have synthesized methylammonium based two metal halide perovskites (MHP) such as MAPbBr3, and MAPbI3 using methylammonium bromide, methylammonium iodide, lead bromide, respective at room temperature under certain experimental conditions. All synthesized MHPs have been confirmed through X-ray diffraction technique (XRD), scanning electron microscope (SEM), Fourier transform infra-red (FTIR) and photoluminescence (PL) analysis. Afterward, comparative evaluation on optical sensing capability has been made for both MHPs using PL in different solvents. Importantly, we find out that MAPbBr3 exhibit an excellent optical feature over MAPbI3 in hexane only. Afterward, MAPbBr3 has also been explored to know the sensing capability for nitrobenzene sensing. Our model study confirms that MAPbBr3 is an excellent sensing material with R square (0.87), selectivity (16.9%) and Stern Volmer constant (Ksv=10- 2 × 0.464) for nitrobenzene in hexane. + © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. + + + + Sikka + Rajat + R + + Materials Application Research Lab, Department of Nano Sciences and Materials, Central University of Jammu, 181143, Jammu, India. + + + + Kumar + Pawan + P + + Materials Application Research Lab, Department of Nano Sciences and Materials, Central University of Jammu, 181143, Jammu, India. pawan.nsm@cujammu.ac.in. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Netherlands + J Fluoresc + 9201341 + 1053-0509 + + IM + + MAPbBr3 + MAPbI3 + Nitrobenzene + Perovskites + sensing + +
+ + + + 2023 + 01 + 02 + + + 2023 + 02 + 07 + + + 2023 + 2 + 22 + 13 + 46 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809412 + 10.1007/s10895-023-03174-7 + 10.1007/s10895-023-03174-7 + + + + Kojima A, Teshima K, Shirai Y, Miyasaka T (2009) Organometal halide perovskites as visible-light sensitizers for photovoltaic cells. J Am Chem Soc 131(17):6050–6051 + + 10.1021/ja809598r + 19366264 + + + + Lee MM, Teuscher J, Miyasaka T, Murakami TN, Snaith HJ (2012) Efficient hybrid solar cells based on meso-superstructured organometal halide perovskites. Science 338(6107):643–647 + + 10.1126/science.1228604 + 23042296 + + + + Xing G, Mathews N, Lim SS, Yantara N, Liu X, Sabba D, …, Sum TC (2014) Low-temperature solution-processed wavelength-tunable perovskites for lasing. Nat Mater 13(5):476–480 + + 10.1038/nmat3911 + 24633346 + + + + Deschler F, Price M, Pathak S, Klintberg LE, Jarausch DD, Higler R, Friend RH (2014) High photoluminescence efficiency and optically pumped lasing in solution-processed mixed halide perovskite semiconductors. J Phys Chem Lett 5(8):1421–1426 + + 10.1021/jz5005285 + 26269988 + + + + Zhang Q, Ha ST, Liu X, Sum TC, Xiong Q (2014) Room-temperature near-infrared high-Q perovskite whispering-gallery planar nanolasers. Nano Lett 14(10):5995–6001 + + 10.1021/nl503057g + 25118830 + + + + Zhu H, Fu Y, Meng F, Wu X, Gong Z, Ding Q, Zhu XY (2015) Lead halide perovskite nanowire lasers with low lasing thresholds and high-quality factors. Nat Mater 14(6):636–642 + + 10.1038/nmat4271 + 25849532 + + + + Correa-Baena JP, Saliba M, Buonassisi T, Grätzel M, Abate A, Tress W, Hagfeldt A (2017) Promises and challenges of perovskite solar cells. Science 358(6364):739–744 + + 10.1126/science.aam6323 + 29123060 + + + + Lu L, Weng W, Ma Y, Liu Y, Han S, Liu X, Luo J (2022) Anisotropy in a 2D Perovskite Ferroelectric drives self-powered polarization‐sensitive photoresponse for Ultraviolet Solar‐Blind Polarized‐Light Detection. Angewandte Chemie + + + Liu Y, Pan X, Liu X, Han S, Wang J, Lu L, Luo J (2022) Tailoring interlayered spacers of Two-Dimensional Cesium‐Based Perovskite ferroelectrics toward exceptional Ferro‐Pyro‐Phototronic Effects. Small 18(11):2106888 + + 10.1002/smll.202106888 + + + + Lu LQ, Tan T, Tian XK, Li Y, Deng P (2017) Visual and sensitive fluorescent sensing for ultratrace mercury ions by perovskite quantum dots. Anal Chim Acta 986:109–114 + + 10.1016/j.aca.2017.07.014 + 28870314 + + + + Sheng X, Liu Y, Wang Y, Li Y, Wang X, Wang X, Xu X (2017) Cesium lead halide perovskite quantum dots as a photoluminescence probe for metal ions. Adv Mater 29(37):1700150 + + 10.1002/adma.201700150 + + + + Dou L, Wong AB, Yu Y, Lai M, Kornienko N, Eaton SW, Yang P (2015) Atomically thin two-dimensional organic-inorganic hybrid perovskites. Science 349(6255):1518–1521 + + 10.1126/science.aac7660 + 26404831 + + + + Tabuchi Y, Asai K, Rikukawa M, Sanui K, Ishigure K (2000) Preparation and characterization of natural lower dimensional layered perovskite-type compounds. J Phys Chem Solids 61(6):837–845 + + 10.1016/S0022-3697(99)00402-3 + + + + Manser JS, Saidaminov MI, Christians JA, Bakr OM, Kamat PV (2016) Making and breaking of lead halide perovskites. Acc Chem Res 49(2):330–338 + + 10.1021/acs.accounts.5b00455 + 26789596 + + + + Li CC, Zhang W, Ang H, Yu H, Xia BY, Wang X, …, Yan Q (2014) Compressed hydrogen gas-induced synthesis of Au–Pt core–shell nanoparticle chains towards high-performance catalysts for Li–O 2 batteries. J Mater Chem A 2(27):10676–10681 + + 10.1039/C4TA01475H + + + + Niu G, Guo X, Wang L (2015) Review of recent progress in chemical stability of perovskite solar cells. J Mater Chem A 3(17):8970–8980 + + 10.1039/C4TA04994B + + + + Kumar P, Paul AK, Deep A (2014) Sensitive chemo-sensing of nitro group containing organophosphate pesticides with MOF-5. Microporous Mesoporous Mater 195:60–66 + + 10.1016/j.micromeso.2014.04.017 + + + + McKenna B, Shivkumar A, Charles B, Evans RC (2020) Synthetic factors affecting the stability of methylammonium lead halide perovskite nanocrystals. Nanoscale 12(21):11694–11702 + + 10.1039/D0NR03227A + 32441286 + + + + Elbaz GA, Straus DB, Semonin OE, Hull TD, Paley DW, Kim P, …, Roy X (2017) Unbalanced hole and electron diffusion in lead bromide perovskites. Nano Lett 17(3):1727–1732 + + 10.1021/acs.nanolett.6b05022 + 28240556 + + + + Li TI, Stucky GD (1973) Exchange interactions in polynuclear transition metal complexes. Structural properties of cesium tribromocuprate (II), CsCuBr3, a strongly coupled copper (II) system. Inorg Chem 12(2):441–445 + + 10.1021/ic50120a040 + + + + Yamada Y, Yamada T, Phuong LQ, Maruyama N, Nishimura H, Wakamiya A, Kanemitsu Y (2015) Dynamic optical properties of CH3NH3PbI3 single crystals as revealed by one-and two-photon excited photoluminescence measurements. J Am Chem Soc 137(33):10456–10459 + + 10.1021/jacs.5b04503 + 26263192 + + + + McGovern L, Futscher MH, Muscarella LA, Ehrler B (2020) Understanding the stability of MAPbBr3 versus MAPbI3: suppression of methylammonium migration and reduction of halide migration. J Phys Chem Lett 11(17):7127–7132 + + 10.1021/acs.jpclett.0c01822 + 32787314 + 7476026 + + + + Levchuk I, Herre P, Brandl M, Osvet A, Hock R, Peukert W, Brabec CJ (2017) Ligand-assisted thickness tailoring of highly luminescent colloidal CH3 NH3 PbX3 (X = br and I) perovskite nanoplatelets. Chem Commun 53(1):244–247 + + 10.1039/C6CC09266G + + + + Nagabhushanaa GP, Shivaramaiaha R, Navrotsky A (2016) Direct calorimetric verification of thermodynamic instability of lead halide hybrid perovskites. Proceedings of the National Academy of Sciences, 113(28), 7717–7721 + + + Bagheri M, Masoomi MY, Morsali A, Schoedel A (2016) Two-dimensional host–guest metal–organic framework sensor with high selectivity and sensitivity to picric acid, vol 8. ACS applied materials & interfaces, pp 21472–21479 + + + Nagarkar SS, Desai AV, Samanta P, Ghosh SK (2015) Aqueous phase selective detection of 2, 4, 6- trinitrophenol using a fluorescent metal–organic framework with a pendant recognition site. Dalton Trans 44:15175–15180 + + 10.1039/C5DT00397K + 25797881 + + + + +
+ + + 36809400 + + 2023 + 02 + 22 + +
+ + 1618-0860 + + + 2023 + Feb + 21 + + + Journal of plant research + J Plant Res + + Sympatric co-existence of two ecotypes of Impatiens noli-tangere (Balsaminaceae) with different morphology and flowering phenology. + 10.1007/s10265-023-01444-w + + In angiosperms, intraspecific variation of flowering phenology may affect reproductive isolation and, consequently, speciation. This study focused on Impatiens noli-tangere (Balsaminaceae), which is distributed over broad latitudinal and altitudinal ranges in Japan. We aimed to reveal the phenotypic mixture of two ecotypes of I. noli-tangere with different flowering phenology and morphological traits in a narrow contact zone. Previous studies have shown that I. noli-tangere has early- and late-flowering types. The early-flowering type makes buds in June and is distributed at high-elevation sites. The late-flowering type makes buds in July and is distributed at low-elevation sites. In this study, we analyzed the flowering phenology of individuals at an intermediate elevation site where the early- and late-flowering types grow in sympatry (contact zone). We found no individuals showing intermediate flowering phenology at the contact zone, and early- and late-flowering types were clearly distinguishable. We also found that the differences in many other phenotypic traits between the early- and late-flowering types were maintained, including the number of flowers produced (total number of chasmogamous and cleistogamous flowers), leaf morphology (aspect ratio, number of serrations), seed traits (aspect ratio), and flower bud formation positions on the plant. This study showed that these two flowering ecotypes maintain many different traits in sympatry. + © 2023. The Author(s) under exclusive licence to The Botanical Society of Japan. + + + + Toji + Tsubasa + T + http://orcid.org/0000-0003-4899-3390 + + Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. tsubasa.toji@gmail.com. + + + + Yamamoto + Tetsuya + T + + Department of Biology, Faculty of Science, Shinshu University, Matsumoto, 3-1-1 Asahi, Nagano, 390-8621, Japan. + + + + Kondo + Hikaru + H + + Department of Biology, Faculty of Science, Shinshu University, Matsumoto, 3-1-1 Asahi, Nagano, 390-8621, Japan. + + + + Shinohara + Yoshinori + Y + + Department of Biology, Faculty of Science, Shinshu University, Matsumoto, 3-1-1 Asahi, Nagano, 390-8621, Japan. + + + + Itino + Takao + T + http://orcid.org/0000-0001-6797-7623 + + Department of Biology, Faculty of Science, Shinshu University, Matsumoto, 3-1-1 Asahi, Nagano, 390-8621, Japan. + + + Institute of Mountain Science, Shinshu University, Matsumoto, 3-1-1 Asahi, Nagano, 390-8621, Japan. + + + + eng + + + 19J22443 + Japan Society for the Promotion of Science + + + + 19H03300 + Japan Society for the Promotion of Science + + + + 22J00636 + Japan Society for the Promotion of Science + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Japan + J Plant Res + 9887853 + 0918-9440 + + IM + + Contact zone + Flowering ecotype + Leaf morphology + Seed morphology + Trait differentiation + +
+ + + + 2023 + 01 + 04 + + + 2023 + 02 + 13 + + + 2023 + 2 + 22 + 13 + 46 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809400 + 10.1007/s10265-023-01444-w + 10.1007/s10265-023-01444-w + + + + Alexander J, Edwards P, Poll M, Parks C, Dietz H (2009) Establishment of parallel altitudinal clines in traits of native and introduced forbs. Ecology 90:612–622 + + 10.1890/08-0453.1 + 19341133 + + + + Bennington CC, McGraw JB (1995) Natural selection and ecotypic differentiation in Impatiens pallida. Ecol Monogr 65:303–323 + + 10.2307/2937062 + + + + Bronstein JL, Gouyon P-H, Gliddon C, Kjellberg F, Michaloud G (1990) The ecological consequences of flowering asynchrony in monoecious figs: a simulation study. Ecology 71:2145–2156 + + 10.2307/1938628 + + + + Fabbro T, Korner C (2004) Altitudinal differences in flower traits and reproductive allocation. Flora 199:70–81 + + 10.1078/0367-2530-00128 + + + + Freeman BG, Lee-Yaw JA, Sunday JM, Hargreaves AL (2018) Expanding, shifting and shrinking: the impact of global warming on species’ elevational distributions. Glob Ecol Biogeogr 27:1268–1276 + + 10.1111/geb.12774 + + + + Hatcher PE (2003) Impatiens noli-tangere L. J Ecol 91:147–167 + + 10.1046/j.1365-2745.2003.00741.x + + + + Itino T, Hirao AS (2016) Plant genetic diversity and plant–pollinator interactions along altitudinal gradients. In: Kudo G (ed) Structure and function of mountain ecosystems in Japan. Springer, Tokyo, pp 63–88 + + 10.1007/978-4-431-55954-2_4 + + + + Jonas CS, Geber MA (1999) Variation among populations Clarkia unguiculata (Onagraceae) along altitudinal and latitudinal gradients. Am J Bot 86:333–343 + + 10.2307/2656755 + 10077496 + + + + Korner C (1999) Alpine plant life: functional plant ecology of high mountain ecosystems. Springer, Berlin + + 10.1007/978-3-642-98018-3 + + + + Liu P, Bu C, Chen P, Zhang D, Song Y (2022) Identification of YAB11-NGAL1 controlling leaf serrations through enhanced genome-wide association studies of Populus. bioRxiv + + + Luzuriaga AL, Escudero A, Pérez-García F (2006) Environmental maternal effects on seed morphology and germination in Sinapis arvensis (Cruciferae). Weed Res 46:163–174 + + 10.1111/j.1365-3180.2006.00496.x + + + + Masuda M, Yahara T (1994) Reproductive ecology of a cleistogamous annual, Impatiens noli-tangere L., occurring under different environmental conditions. Ecol Res 9:67–75 + + 10.1007/BF02347243 + + + + Mitsui Y, Nomura N, Isagi Y, Tobe H, Setoguchi H (2010) Ecological barriers to gene flow between riparian and forest species of Ainsliaea (Asteraceae). Evolution 65:335–349 + + 10.1111/j.1558-5646.2010.01129.x + 20840597 + + + + Munguía-Rosas MA, Ollerton J, Parra-Tabla V, De Nova JA (2011) Meta-analysis of phenotypic selection on flowering phenology suggests that early flowering plants are favoured. Ecol Lett 14:511–521 + + 10.1111/j.1461-0248.2011.01601.x + 21332621 + + + + Nomura Y, Shimono Y, Mizuno N, Miyoshi I, Iwakami S, Sato K, Tominaga T (2022) Drastic shift in flowering phenology of F1 hybrids causing rapid reproductive isolation in Imperata cylindrica in Japan. J Ecol 110:1548–1560 + + 10.1111/1365-2745.13890 + + + + Palgunadi MA, Oka NP, Achmad A (2021) Differences in microhabitat and morphology of two sympatric congeneric species Palaquium maliliensis and Palaquium obovatum in the education forest of Hasanuddin University. Earth Environ Sci 886:012043 + + + Pellmyr O (1986) Three pollination morphs in Cimicifuga simplex; incipient speciation due to inferiority in competition. Oecologia 68:304–307 + + 10.1007/BF00384804 + 28310144 + + + + R Core Team (2013) R: A language and environment for statistical computing. R Foundation for Statistical Computing + + + Rathcke B (1983) Competition and facilitation among plants for pollination. In: Real L (ed) Pollination biology. Academic Press, Orlando, pp 305–329 + + 10.1016/B978-0-12-583980-8.50019-3 + + + + Satake Y, Ohwi J, Kitamura S, Watari S, Tominari T (1982) Wild flowers of Japan II—herbaceous plants Choripetalae. Heibonsya, Tokyo + + + Schemske DW (1984) Population structure and local selection in Impatiens pallida (Balsaminaceae), a selfing annual. Evolution 38:817–832 + + 10.2307/2408393 + 28555822 + + + + Schneider CA, Rasband WS, Eliceiri KW (2012) NIH Image to ImageJ: 25 years of image analysis. Nat Methods 9:671–675 + + 10.1038/nmeth.2089 + 22930834 + 5554542 + + + + Setoguchi H, Kajimaru G (2004) Leaf morphology of the rheophyte, Rhododendron indicum f. otakumi (Ericaceae). Acta Phytotaxon Geobot 55:45–54 + + + Shinohara Y, Hattori M, Itino T (2015) Flowering phenology and number polymorphism of Impatiens noli-tangere L. (Balsaminaceae) in Nagano prefecture Japan. Bull Bot Soc Nagano 48:25–28 (in Japanese) + + + Suzuki M, Kaya Y, Ishida TA, Hattori K, Miki K, Nakamura T, Kimura MT (2007) Flowering phenology and survival of two annual plants Impatiens noli-tangere and Persicaria thunbergii co-occurring in streamside environments. Ecol Res 22:496–501 + + 10.1007/s11284-006-0037-5 + + + + Taylor RS, Friesen VL (2017) The role of allochrony in speciation. Mol Ecol 26:3330–3342 + + 10.1111/mec.14126 + 28370658 + + + + Toji T, Itino T (2020) Differences in sex expression and mating systems in three pollination morphs of Cimicifuga simplex. Plant Species Biol 35:112–119 + + 10.1111/1442-1984.12265 + + + + Toji T, Ishimoto N, Itino T (2020) Seasonal change of flower sex ratio and pollinator dynamics in three reproductive ecotypes of protandrous plant. Ecosphere 11:e03251 + + 10.1002/ecs2.3251 + + + + Tokuda N, Hattroi M, Abe K, Shinohara Y, Nagano Y, Itino T (2015) Demonstration of pollinator-mediated competition between two native Impatiens species, Impatiens noli-tangere and I. textori (Balsaminaceae). Ecol Evol 5:1271–1277 + + 10.1002/ece3.1431 + 25859332 + 4377270 + + + + Tsukaya H (2002) Leaf anatomy of rheophyte, Dendranthema yoshinaganthum (Asteraceae), and of hybrids between D. yoshinaganthum and a closely related non-rheophyte. D Indicum J Plant Res 115:329–333 + + 10.1007/s10265-002-0041-y + 12579357 + + + + Yates MJ, Anthony Verboom G, Rebelo AG, Cramer MD (2010) Ecophysiological significance of leaf size variation in Proteaceae from the Cape Floristic Region. Funct Ecol 24:485–492 + + 10.1111/j.1365-2435.2009.01678.x + + + + +
+ + + 36809402 + + 2023 + 02 + 22 + +
+ + 1526-4637 + + + 2023 + Feb + 21 + + + Pain medicine (Malden, Mass.) + Pain Med + + A tactile pain evaluation scale for visually deficient persons. + pnad013 + 10.1093/pm/pnad013 + + Pain evaluation scales often rely on the sense of sight. There is so far no pain assessment scale specifically designed for persons with visual impairment. + This study aims to validate a tactile pain evaluation scale, Visiodol©, in blind/visually impaired persons, by correlation with a numeric pain scale (NPS). + The study took place in University Hospital Clermont-Fd, France. + Pain intensity for a range of thermal stimuli (Pathway Medoc®) was evaluated with Visiodol© and NPS; secondary outcomes including pain thresholds, catastrophizing, emotion and quality of life were compared in blind/visually impaired and sighted persons. Lin's concordance correlation coefficient was estimated; weighted Cohen κ accounted for degrees of disagreement between scales with 95% confidence interval (95%CI). + 21 healthy sighted and 21 healthy non-sighted volunteers (n = 13 congenital, n = 8 acquired) were included. + Lin's correlation coefficient for repeated data was 0.967 (95%CI, 0.956; 0.978; P < 0.001) for visually impaired participants with a good agreement at each temperature plateau. Weighted Cohen κ of 0.90 (95% CI, 0.84-0.92) and 92.9% percentage of agreement for visually impaired participants was satisfactory. Pain perception, psychological components and quality of life were more impaired in blind/visually impaired persons than in sighted persons. + This study validates Visiodol©, a tactile scale for blind/visually impaired persons and addresses healthcare inequalities in the context of pain evaluation. It will now be tested on a larger population of patients in order to give the millions of blind/visually impaired persons worldwide, an option for pain intensity evaluation in clinical situations. + © The Author(s) 2023. Published by Oxford University Press on behalf of the American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. + + + + Pickering + Gisèle + G + + Plateforme d'Investigation Clinique (PIC/CIC), University Hospital Clermont-Ferrand, INSERM CIC 1405, F-63000, Clermont-Ferrand, France. + + + University Clermont Auvergne, Inserm 1107, F-63000, Clermont-Ferrand, France. + + + + Morel + Véronique + V + + Plateforme d'Investigation Clinique (PIC/CIC), University Hospital Clermont-Ferrand, INSERM CIC 1405, F-63000, Clermont-Ferrand, France. + + + + Goubayon + Jonathan + J + + Plateforme d'Investigation Clinique (PIC/CIC), University Hospital Clermont-Ferrand, INSERM CIC 1405, F-63000, Clermont-Ferrand, France. + + + + Touron + Ambre + A + + Plateforme d'Investigation Clinique (PIC/CIC), University Hospital Clermont-Ferrand, INSERM CIC 1405, F-63000, Clermont-Ferrand, France. + + + + Leray + Vincent + V + + Plateforme d'Investigation Clinique (PIC/CIC), University Hospital Clermont-Ferrand, INSERM CIC 1405, F-63000, Clermont-Ferrand, France. + + + + Pereira + Bruno + B + + Clinical Research and Innovation Department, University Hospital Clermont-Ferrand, F-63000, Clermont-Ferrand, France. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Pain Med + 100894201 + 1526-2375 + + IM + + blindness + pain assessment + quality of life + +
+ + + + 2022 + 09 + 26 + + + 2023 + 01 + 17 + + + 2023 + 01 + 17 + + + 2023 + 2 + 22 + 13 + 46 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809402 + 7049536 + 10.1093/pm/pnad013 + + +
+ + + 36809417 + + 2023 + 02 + 22 + +
+ + 1432-5195 + + + 2023 + Feb + 21 + + + International orthopaedics + Int Orthop + + Synovial plica of the elbow - detailed measurements and how to implicate its relevance in clinical practice. + 10.1007/s00264-023-05726-9 + + The synovial plica of the elbow is a fold of synovial tissue, which is said to be a remnant of the embryonic septa of normal articular development and is located around the radiocapitellar joint. The objective of the present study was to provide morphometric properties of the synovial plica of the elbow and its relation to surrounding structures in asymptomatic patients. + A retrospective study was conducted to establish the morphometric characteristics of the synovial plica of the elbow. The results of 216 consecutive patients, who for different reasons during the five year period of time underwent magnetic resonance imaging (MRI) of an elbow, were analyzed. + Plica was found in a total of 161 of 216 elbows (74.5%). The mean width of the plica was set to be 3.00 mm (SD: 1.39). The mean length of the plica was established at 2.91 mm (SD: 1.13). An analysis of sexual dimorphism was also included. Potential correlations were analyzed for each of the categories and age. + The synovial plica of the elbow is a clinically relevant anatomical structure. Analyzing the morphometric parameters of the synovial plica is necessary to properly evaluate synovial plica syndrome, which can commonly be confused with other sources of lateral elbow pain such as tennis elbow, oppression of the radial and/or posterior interosseous nerve, or snapping of the triceps tendon. The authors suggest that the thickness of the plica may not be the golden diagnostic feature as there are no statistically significant differences in this parameter between symptomatic and asymptomatic patients. A precise and accurate diagnosis of synovial fold syndrome and/or differentiation from other sources of lateral elbow pain must be performed, as the surgical treatment, even if performed properly, will be unsuccessful because of a misdiagnosed source of pain. + © 2023. The Author(s). + + + + Bonczar + Michał + M + http://orcid.org/0000-0003-2080-165X + + Department of Anatomy, Jagiellonian University Medical College, Mikołaja Kopernika 12, 33-332, Cracow, Poland. michalbonczar01@gmail.com. + + + Youthoria, Youth Research Organization, Cracow, Poland. michalbonczar01@gmail.com. + + + + Ostrowski + Patryk + P + + Department of Anatomy, Jagiellonian University Medical College, Mikołaja Kopernika 12, 33-332, Cracow, Poland. + + + Youthoria, Youth Research Organization, Cracow, Poland. + + + + Bednarz + Wojciech + W + + Department of Anatomy, Jagiellonian University Medical College, Mikołaja Kopernika 12, 33-332, Cracow, Poland. + + + Department of Radiology, Jagiellonian University Medical College, Cracow, Poland. + + + + Wojciechowski + Wadim + W + + Department of Radiology, Jagiellonian University Medical College, Cracow, Poland. + + + + Walocha + Jerzy + J + + Department of Anatomy, Jagiellonian University Medical College, Mikołaja Kopernika 12, 33-332, Cracow, Poland. + + + Youthoria, Youth Research Organization, Cracow, Poland. + + + + Koziej + Mateusz + M + + Department of Anatomy, Jagiellonian University Medical College, Mikołaja Kopernika 12, 33-332, Cracow, Poland. + + + Youthoria, Youth Research Organization, Cracow, Poland. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Int Orthop + 7705431 + 0341-2695 + + IM + + Elbow pain + Elbow synovial fold + Elbow synovial fold syndrome + Lateral elbow + Plica + Radiohumeral joint + +
+ + + + 2023 + 01 + 17 + + + 2023 + 02 + 07 + + + 2023 + 2 + 22 + 13 + 46 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809417 + 10.1007/s00264-023-05726-9 + 10.1007/s00264-023-05726-9 + + + + Cerezal L, Rodriguez-Sammartino M, Canga A et al (2013) Elbow synovial fold syndrome. Am J Roentgenol 201:W88–W96. https://doi.org/10.2214/AJR.12.8768 + + 10.2214/AJR.12.8768 + + + + Duparc F, Putz R, Michot C et al (2002) The synovial fold of the humeroradial joint: anatomical and histological features, and clinical relevance in lateral epicondylalgia of the elbow. Surg Radiol Anat 24:302–307. https://doi.org/10.1007/s00276-002-0055-0 + + 10.1007/s00276-002-0055-0 + 12497221 + + + + Isogai S, Murakami G, Wada T, Ishii S (2001) Which morphologies of synovial folds result from degeneration and/or aging of the radiohumeral joint: an anatomic study with cadavers and embryos. J Shoulder Elbow Surg 10:169–181. https://doi.org/10.1067/mse.2001.112956 + + 10.1067/mse.2001.112956 + 11307082 + + + + Lubiatowski P, Wałecka J, Dzianach M et al (2020) Synovial plica of the elbow and its clinical relevance. EFORT Open Rev 5:549–557. https://doi.org/10.1302/2058-5241.5.200027 + + 10.1302/2058-5241.5.200027 + 33072407 + 7528666 + + + + Kholinne E, Nanda A, Liu H et al (2021) The elbow plica: a systematic review of terminology and characteristics. J Shoulder Elbow Surg 30:e185–e198. https://doi.org/10.1016/j.jse.2020.09.011 + + 10.1016/j.jse.2020.09.011 + 33038495 + + + + Koh S, Morris RP, Andersen CL et al (2007) Ultrasonographic examination of the synovial fold of the radiohumeral joint. J Shoulder Elbow Surg 16:609–615. https://doi.org/10.1016/j.jse.2006.10.019 + + 10.1016/j.jse.2006.10.019 + 17507252 + + + + Husarik DB, Saupe N, Pfirrmann CWA et al (2010) Ligaments and plicae of the elbow: normal MR imaging variability in 60 asymptomatic subjects. Radiology 257:185–194. https://doi.org/10.1148/radiol.10092163 + + 10.1148/radiol.10092163 + 20697117 + + + + Choi S-H, Ji SK, Lee SA et al (2017) Magnetic resonance imaging of posterolateral plica of the elbow joint: asymptomatic vs. symptomatic subjects. PLoS One 12:e0174320. https://doi.org/10.1371/journal.pone.0174320 + + 10.1371/journal.pone.0174320 + 28622337 + 5473528 + + + + Antuna SA, O’Driscoll SW (2001) Snapping plicae associated with radiocapitellar chondromalacia. Arthrosc - J Arthrosc Relat Surg 17:491–495. https://doi.org/10.1053/jars.2001.20096 + + 10.1053/jars.2001.20096 + + + + Awaya H, Schweitzer ME, Feng SA et al (2001) Elbow synovial fold syndrome. Am J Roentgenol 177:1377–1381. https://doi.org/10.2214/ajr.177.6.1771377 + + 10.2214/ajr.177.6.1771377 + + + + Ruiz de Luzuriaga BC, Helms CA, Kosinski AS, Vinson EN (2013) Elbow MR imaging findings in patients with synovial fringe syndrome. Skeletal Radiol 42:675–680. https://doi.org/10.1007/s00256-012-1523-1 + + 10.1007/s00256-012-1523-1 + 23011477 + + + + Celikyay F, Inanir A, Bilgic E, Ozmen Z (2015) Ultrasonographic evaluation of the posterolateral radiohumeral plica in asymptomatic subjects and patients with osteoarthritis. Med Ultrason 17:155. https://doi.org/10.11152/mu.2013.2066.172.usev + + 10.11152/mu.2013.2066.172.usev + 26052564 + + + + Obuchowicz R, Bonczar M (2016) Ultrasonographic differentiation of lateral elbow pain. Ultrasound Int Open 02:E38–E46. https://doi.org/10.1055/s-0035-1569455 + + 10.1055/s-0035-1569455 + + + + Abhimanyu V, Ritika P, Osama N et al (2021) Lateral epicondylitis: are we missing out on radial nerve involvement? A cross-sectional study. J Bodyw Mov Ther 27:352–357. https://doi.org/10.1016/j.jbmt.2021.01.014 + + 10.1016/j.jbmt.2021.01.014 + 34391257 + + + + +
+ + + 36809410 + + 2023 + 02 + 22 + +
+ + 1530-8898 + + + 2023 + Feb + 20 + + + Journal of cognitive neuroscience + J Cogn Neurosci + + Behavioral and Neural Trajectories of Risk Taking for Peer and Parent in Adolescence. + + 1-14 + + 10.1162/jocn_a_01974 + + One feature of adolescence is a rise in risk-taking behaviors, whereby the consequences of adolescents' risky action often impact their immediate surrounding such as their peers and parents (vicarious risk taking). Yet, little is known about how vicarious risk taking develops, particularly depending on who the risk affects and the type of risky behavior. In a 3-wave longitudinal fMRI study, 173 adolescents completed 1-3 years of a risky decision-making task where they took risks to win money for their best friend and parent (N with behavioral and fMRI data ranges from 139-144 and 100-116 participants, respectively, per wave). Results of this preregistered study suggest that adolescents did not differentially take adaptive (sensitivity to the expected value of reward during risk taking) and general (decision-making when the expected values of risk taking and staying safe are equivalent) risks for their best friend and parent from sixth to ninth grade. At the neural level, preregistered ROI analyses revealed no differences in the ventral striatum and ventromedial pFC during general nor adaptive risk taking for best friend versus parent over time. Furthermore, exploratory longitudinal whole-brain analyses revealed subthreshold differences between best friend and parent trajectories within regulatory regions during general vicarious risk taking and social-cognitive regions during adaptive vicarious risk taking. Our findings demonstrate that brain regions implicated in cognitive control and social-cognitive processes may distinguish behaviors involving peers and parents over time. + © 2023 Massachusetts Institute of Technology. + + + + Kwon + Seh-Joo + SJ + 0000-0002-0136-5074 + + University of North Carolina, Chapel Hill. + + + + Flannery + Jessica E + JE + + University of North Carolina, Chapel Hill. + + + + Turpyn + Caitlin C + CC + + University of North Carolina, Chapel Hill. + + + + Prinstein + Mitchell J + MJ + + University of North Carolina, Chapel Hill. + + + + Lindquist + Kristen A + KA + + University of North Carolina, Chapel Hill. + + + + Telzer + Eva H + EH + + University of North Carolina, Chapel Hill. + + + + eng + + + F32DA04946 + National Institutes of Health + + + + R01DA039923 + National Institutes of Health + + + + SES 1459719 + National Science Foundation + + + + + Journal Article + + + 2023 + 02 + 20 + +
+ + United States + J Cogn Neurosci + 8910747 + 0898-929X + + IM +
+ + + + 2023 + 2 + 22 + 13 + 46 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809410 + 114945 + 10.1162/jocn_a_01974 + + +
+ + + 36809414 + + 2023 + 02 + 22 + +
+ + 1436-5073 + + 190 + 3 + + 2023 + Feb + 21 + + + Mikrochimica acta + Mikrochim Acta + + Self-powered DNA nanomachines for fluorescence detection of lead. + + 99 + + 10.1007/s00604-023-05673-7 + + A versatile DNA nanomachine detection system has been developed via the combination of DNAzyme with catalytic hairpin assembly (CHA) technology for achieving accurate and sensitive detection of lead ions (Pb2+). In the presence of target Pb2+, capture DNA nanomachine formed by AuNP and DNAzyme recognized and reacted with Pb2+, which yielded an "active" DNAzyme, that induced the cleavage of substrate strand, and then released the initiator DNA (TT) for CHA. With the help of the initiator DNA TT, self-powered CHA was activated to achieve the signal amplification reaction in the detection of DNA nanomachine. Meanwhile, the initiator DNA TT was released and hybridized with the other H1 strand to initiate another CHA, replacement, and turnovers, producing enhanced fluorescence signal of fluorophore FAM (excitation 490 nm/emission 520 nm) for sensitive determination of Pb2+. Under the optimized conditions, the DNA nanomachine detection system revealed high selectivity toward Pb2+ in the concentration range 50-600 pM, with the limit of detection (LOD) of 31 pM. Recovery tests demonstrated that the DNA nanomachine detection system has excellent detection capability in real samples. Therefore, the proposed strategy can be extended and act as a basic platform for highly accurate and sensitive detection of various heavy metal ions. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature. + + + + Li + Xiang-Ling + XL + http://orcid.org/0000-0001-8198-9778 + + State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, People's Republic of China. + + + + Jiang + Han + H + + State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, People's Republic of China. + + + + Zhao + Lei + L + + State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, People's Republic of China. + + + + Song + Tian Shun + TS + + State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, People's Republic of China. + + + + Xie + Jing Jing + JJ + + State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, People's Republic of China. xiej@njtech.edu.cn. + + + + eng + + + 2018YFA0901300 + the National Key Research and Development Program of China + + + + 21878150 + National Natural Science Foundation of China + + + + 21904092 + National Natural Science Foundation of China + + + + 22078149 + National Natural Science Foundation of China + + + + BK20220002 + Natural Science Foundation of Jiangsu Province + + + + 20KJB150020 + Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions + + + + 39808129 + Fundamental Research Funds for Promotion Project + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Austria + Mikrochim Acta + 7808782 + 0026-3672 + + IM + + Catalytic hairpin assembly + DNAzyme + Lead ions + Self-powered + +
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+ + + 36809416 + + 2023 + 02 + 22 + +
+ + 1432-1750 + + + 2023 + Feb + 21 + + + Lung + Lung + + Association between serum Vitamin D levels and asthma severity and control in children and adolescents. + 10.1007/s00408-023-00605-x + + To assess the association of serum Vitamin D (vitD) levels with asthma control and severity in children and adolescents in different seasons of the year. + Longitudinal, prospective study with 7- to 17-year-old children and adolescents diagnosed with asthma. All participants underwent two assessments conducted in opposite seasons of the year which included a clinical assessment, a questionnaire for classification of asthma control (Asthma Control Test), spirometry, and blood collection to measure serum vitD levels. + In total, 141 individuals with asthma were evaluated. The mean vitD was lower in females (p = 0.006) and sunlight exposure appears not to be an influencing factor for vitD levels. We found no differences in mean vitD of patients with controlled and uncontrolled asthma (p = 0.703; p = 0.956). However, the severe asthma group had lower mean Vitamin D than the mild/moderate asthma group for both assessments (p = 0.013; p = 0.032). In the first assessment, the group with vitD insufficiency had a higher prevalence of severe asthma (p = 0.015). Vitamin D was positively correlated with FEV1 in both assessments (p = 0.008; p = 0.006) and with FEF25-75% in the first assessment (p = 0.038). + In a tropical climate zone, there is no evidence of association between seasonality and serum vitD levels or between serum vitD levels and asthma control in children and adolescents. However, vitD and lung function were positively correlated and the group with vitD insufficiency had a higher prevalence of severe asthma. + © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. + + + + Malheiro + Ana Paula G + APG + http://orcid.org/0000-0002-7556-4893 + + Child and Adolescent Health Postgraduate Program, State University of Campinas, Campinas, Brazil. anamgaban@gmail.com. + + + Laboratory of Pulmonary Physiology, School of Medical Sciences, Center for Investigation in Pediatrics, Universitária Zeferino Vaz, Tessália Vieira de Camargo Street, 126, Cidade, Campinas, São Paulo, 13083-887, Brazil. anamgaban@gmail.com. + + + + Gianfrancesco + Lívea + L + http://orcid.org/0000-0003-2963-8860 + + Child and Adolescent Health Postgraduate Program, State University of Campinas, Campinas, Brazil. + + + Laboratory of Pulmonary Physiology, School of Medical Sciences, Center for Investigation in Pediatrics, Universitária Zeferino Vaz, Tessália Vieira de Camargo Street, 126, Cidade, Campinas, São Paulo, 13083-887, Brazil. + + + + Nogueira + Roberto José N + RJN + http://orcid.org/0000-0002-4833-3571 + + Department of Pediatrics, School of Medical Sciences, State University of Campinas, Campinas, Brazil. + + + Department of Pediatrics, School of Medicine, São Leopoldo Mandic, Campinas, Brazil. + + + + Grotta + Milena B + MB + http://orcid.org/0000-0002-1483-049X + + Laboratory of Pulmonary Physiology, School of Medical Sciences, Center for Investigation in Pediatrics, Universitária Zeferino Vaz, Tessália Vieira de Camargo Street, 126, Cidade, Campinas, São Paulo, 13083-887, Brazil. + + + Department of Pediatrics, School of Medical Sciences, State University of Campinas, Campinas, Brazil. + + + + Morcillo + André M + AM + http://orcid.org/0000-0002-2088-972X + + Department of Pediatrics, School of Medical Sciences, State University of Campinas, Campinas, Brazil. + + + + Ribeiro + José Dirceu + JD + http://orcid.org/0000-0002-3387-5642 + + Laboratory of Pulmonary Physiology, School of Medical Sciences, Center for Investigation in Pediatrics, Universitária Zeferino Vaz, Tessália Vieira de Camargo Street, 126, Cidade, Campinas, São Paulo, 13083-887, Brazil. + + + Department of Pediatrics, School of Medical Sciences, State University of Campinas, Campinas, Brazil. + + + + Toro + Adyléia A D C + AADC + http://orcid.org/0000-0001-5777-1146 + + Laboratory of Pulmonary Physiology, School of Medical Sciences, Center for Investigation in Pediatrics, Universitária Zeferino Vaz, Tessália Vieira de Camargo Street, 126, Cidade, Campinas, São Paulo, 13083-887, Brazil. + + + Department of Pediatrics, School of Medical Sciences, State University of Campinas, Campinas, Brazil. + + + + eng + + + 174296 + Coordenação de Aperfeiçoamento de Pessoal de Nível Superior , Brasil + + + + 2016/22102-8 + Fundação de Amparo à Pesquisa do Estado de São Paulo + + + + 2016/22102-8 + Fundação de Amparo à Pesquisa do Estado de São Paulo + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Lung + 7701875 + 0341-2040 + + IM + + 25-hydroxyvitamin D + Asthma Control Test + Child + Lung function + Seasons + +
+ + + + 2022 + 12 + 13 + + + 2023 + 02 + 03 + + + 2023 + 2 + 22 + 13 + 46 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809416 + 10.1007/s00408-023-00605-x + 10.1007/s00408-023-00605-x + + + + Pfeffer PE, Hawrylowicz CM (2018) Vitamin D in asthma: mechanisms of action and considerations for clinical trials. Chest 153:1229–1239 + + 10.1016/j.chest.2017.09.005 + 28923762 + + + + Wang M, Liu M, Wang C, Xiao Y, An T, Zou M, Cheng G (2019) Association between vitamin D status and asthma control: a meta-analysis of randomized trials. Respir Med 150:85–94 + + 10.1016/j.rmed.2019.02.016 + 30961957 + + + + Hall SC, Agrawal DK (2017) Vitamin D and bronchial asthma: an overview of data from the past 5 years. Clin Ther 39:917–929 + + 10.1016/j.clinthera.2017.04.002 + 28449868 + 5607643 + + + + Jat KR, Khairwa A (2017) Vitamin D and asthma in children: A systematic review and meta-analysis of observational studies. Lung India 34:355–363 + + 10.4103/0970-2113.209227 + 28671167 + 5504893 + + + + Cassim R, Russell MA, Lodge CJ, Lowe AJ, Koplin JJ, Dharmage SC (2015) The role of circulating 25 hydroxyvitamin D in asthma: a systematic review. Allergy 70:339–354 + + 10.1111/all.12583 + 25631639 + + + + Gupta A, Bhat G, Pianosi P (2018) What is new in the management of childhood asthma? The Indian Journal of Pediatrics 85:773–781 + + 10.1007/s12098-018-2705-1 + 29948729 + + + + de Paula FJ, Rosen CJ (2012) Vitamin D safety and requirements. Arch Biochem Biophys 523:64–72 + + 10.1016/j.abb.2011.12.002 + 22179017 + + + + Litonjua AA (2019) Vitamin D and childhood asthma: causation and contribution to disease activity. Curr Opin Allergy Clin Immunol 19:126–131 + + 10.1097/ACI.0000000000000509 + 30608234 + 6395509 + + + + Paul G, Brehm JM, Alcorn JF, Holguín F, Aujla SJ, Celedón JC (2012) Vitamin D and asthma. Am J Respir Crit Care Med 185:124–132 + + 10.1164/rccm.201108-1502CI + 22016447 + 3297088 + + + + Szymczak I, Pawliczak R (2018) Can vitamin D help in achieving asthma control? Vitamin D “revisited”: an updated insight. Adv Respir Med 86:103–109 + + 10.5603/ARM.2018.0015 + 29709052 + + + + Özdoğan Ş (2019) Seasonal, sex variations in vitamin d levels and their association with pulmonary function in children with asthma. Turk J Med Sci 49:1534–1539 + + 10.3906/sag-1904-112 + 31651126 + 7018226 + + + + Global Initiative for Asthma [Internet]. R: Global strategy for asthma management and prevention. Updated 2020 [cited 2021–06–21]. Available from: www.ginaasthma.org . + + + Purple JPF, Bridge EV, Branches DCB, Pimentel L, Junior ADO, Cross AA (2010) English-language version of the asthma control test: validation for use in Brazil. J Bras Pneumol 36:159–166 + + + Holgate ST, Price D, Valovirta E (2006) Asthma out of control? A structured review of recent patient surveys. BMC Pulm Med 6(Suppl 1):S2 + + 10.1186/1471-2466-6-S1-S2 + 17140420 + 1698495 + + + + Voorend-van Bergen S, Vaessen-Verberne AA, de Jongste JC, Pijnenburg MW (2015) Asthma control questionnaires in the management of asthma in children: a review. Pediatr Pulmonol 50:202–208 + + 10.1002/ppul.23098 + 25187271 + + + + Pedersen S (2015) Asthma control in children: is it important and can we measure it? Acta Paediatr Respir Rev 17:36–38 + + + Graham BL, Steenbruggen I, Miller MR, Barjaktarevic IZ, Cooper BG, Hall GL et al (2019) Standardization of Spirometry 2019 Update. An Official American Thoracic Society and European Respiratory Society Technical Statement. Am J Respir Crit Care Med 200:e70–e88 + + 10.1164/rccm.201908-1590ST + 31613151 + 6794117 + + + + Sociedade Brasileira de Pediatria. Hipovitaminose D em pediatria: recomendações para diagnóstico, tratamento e prevenção. Departamento Científico de Endocrinologia. 2016; 1–11. Available from: https://www.sbp.com.br/fileadmin/user_upload/2016/12/Endcrino-Hipovitaminose-D.pdf + + + Batmaz SB, Arıkoğlu T, Tamer L, Eskandari G, Kuyucu S (2018) Seasonal variation of asthma control, lung function tests and allergic inflammation in relation to vitamin D levels: a prospective annual study. Postepy Dermatol Alergol 35:99–105 + + 10.5114/ada.2017.71421 + 29599679 + 5872241 + + + + Kerley CP, Lenoir B, Faul J, Cormican L (2015) Vitamin D as an adjunctive therapy in asthma. part 1: A review of potential mechanisms. Pulm Pharmacol Ther 32:60–74 + + 10.1016/j.pupt.2015.02.004 + 25732539 + + + + Hughes AM, Lucas RM, Ponsonby AL, Chapman C, Coulthard A, Dear K et al (2010) The role of latitude, ultraviolet radiation exposure and vitamin D in childhood asthma and hayfever: an Australian multicenter study. Pediatr Allergy Immunol 22:327–333 + + 10.1111/j.1399-3038.2010.01099.x + 20880353 + + + + Mendes MM, Hart KH, Botelho PB, Lanham-New SA (2018) Vitamin D status in the tropics: Is sunlight exposure the main determinant? Nutr Bull 43:428–434 + + 10.1111/nbu.12349 + + + + Amorim CLCG, Oliveira JM, Rodrigues A, Furlanetto KC, Pitta F (2020) Vitamin D: association with eosinophil counts and IgE levels in children with asthma. J Bras Pneumol 47:e20200279 + + 33174974 + + + + Voorend-van Bergen S, Vaessen-Verberne AA, Landstra AM, Brackel HJ, van den Berg NJ, Caudri D et al (2014) Monitoring childhood asthma: web-based diaries and the asthma control test. J Allergy Clin Immunol 133:1599–605.e2 + + 10.1016/j.jaci.2013.10.005 + 24290276 + + + + Passeron T, Bouillon R, Callender V, Cestari T, Diepgen TL, Green AC et al (2019) Sunscreen photoprotection and vitamin D status. Br J Dermatol 181:916–931 + + 10.1111/bjd.17992 + 31069788 + 6899926 + + + + Binkley N, Novotny R, Krueger D, Kawahara T, Daida YG, Lensmeyer G et al (2007) Low vitamin D status despite abundant sun exposure. J Clin Endocrinol Metab 92:2130–2135 + + 10.1210/jc.2006-2250 + 17426097 + + + + Abboud M, Rybchyn MS, Rizk R, Fraser DR, Mason RS (2017) Sunlight exposure is just one of the factors which influence vitamin D status. Photochem Photobiol Sci 16:302–313 + + 10.1039/c6pp00329j + 28139795 + + + + AlQuaiz AM, Kazi A, Fouda M, Alyousefi N (2018) Age and gender differences in the prevalence and correlates of vitamin D deficiency. Arch Osteoporos 13:4 + + 10.1007/s11657-018-0461-5 + + + + Alansari K, Davidson BL, Yousef KI, Mohamed ANH, Alattar I (2017) Rapid vs Maintenance vitamin D supplementation in deficient children with asthma to prevent exacerbations. Chest 152:527–536 + + 10.1016/j.chest.2017.06.021 + 28651793 + + + + Sharif A, Haddad Kashani H, Sharif MR (2020) Association of 25-hydroxy vitamin D with asthma and its severity in children: a case-control study. Clin Mol Allergy 18:7 + + 10.1186/s12948-020-00122-9 + 32390767 + 7197187 + + + + Montero-Arias F, Sedó-Mejía G, Ramos-Esquivel A (2013) Vitamin D insufficiency and asthma severity in adults from Costa Rica. Allergy Asthma Immunol Res 5:283–288 + + 10.4168/aair.2013.5.5.283 + 24003384 + 3756174 + + + + Brehm JM, Schuemann B, Fuhlbrigge AL, Hollis BW, Strunk RC, Zeiger RS, Weiss ST, Litonjua AA, Childhood Asthma Management Program Research Group (2010) Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study. J Allergy Clin Immunol 126(5):2–58 + + + Liu J, Dong YQ, Yin J, Yao J, Shen J, Sheng GJ, Li K, Lv HF, Fang X, Wu WF (2019) Meta-analysis of vitamin D and lung function in patients with asthma. Respir Res 20:161 + + 10.1186/s12931-019-1072-4 + 31590675 + 6781357 + + + + +
+ + + 36809408 + + 2023 + 02 + 22 + +
+ + 1432-069X + + + 2023 + Feb + 21 + + + Archives of dermatological research + Arch Dermatol Res + + Immune checkpoint inhibitor-induced vitiligo in cancer patients: characterization and management. + 10.1007/s00403-023-02577-7 + + This study highlights the range of non-melanoma cancers where ICI-induced vitiligo can be present and challenges the exclusivity of this phenomenon to melanoma. We believe our manuscript will encourage awareness in our colleagues and stimulate interest in further studies to elucidate the mechanisms of ICI-induced vitiligo in both melanoma and non-melanoma cancers, and to understand whether this phenomenon holds the same positive prognostic value in both cancer groups. This is a retrospective cohort study from a single-institution's electronic medical record for cancer patients treated with ICIs who subsequently developed vitiligo. We identified 151 patients with ICI-induced vitiligo, 19 (12.6%) non-melanoma and 132 (77.4%) melanoma patients. Time to onset of vitiligo was nearly doubled in the non-melanoma cohort, however, this is confounded by possible delayed diagnosis or under reporting of this asymptomatic condition in patients who do not regularly receive skin exams. The majority of patients had a stable course of vitiligo with 91.4% receiving no treatment in this largely Caucasian cohort. Two patients with non-melanoma cancers and Fitzpatrick type IV or above skin received treatment with narrowband ultraviolet B light therapy and topical steroids with near-complete response. This study highlights the occurrence of ICI-induced vitiligo in a variety of non-melanoma cancers, where skin of color patients will be more prevalent and the need for treatment will potentially be more urgent. Further study is needed to elucidate the mechanism of ICI-induced vitiligo and determine if non-melanoma cancers have the same association between vitiligo and increased tumor response. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Lo + Jonathan + J + + Baylor College of Medicine, Houston, TX, USA. + + + + Hanania + Hannah L + HL + http://orcid.org/0000-0002-6155-2226 + + Baylor College of Medicine, Houston, TX, USA. + + + + Keiser + Monika F + MF + http://orcid.org/0000-0003-2990-9456 + + University of Texas McGovern Medical School, Houston, TX, USA. + + + + Patel + Anisha B + AB + http://orcid.org/0000-0002-5372-784X + + Department of Dermatology, University of Texas MD Anderson Cancer Center, Houston, TX, USA. Apatel11@mdanderson.org. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Arch Dermatol Res + 8000462 + 0340-3696 + + IM + + Cutaneous adverse events + Immune checkpoint inhibitor + Non-melanoma + Vitiligo + +
+ + + + 2022 + 06 + 13 + + + 2023 + 02 + 08 + + + 2023 + 01 + 04 + + + 2023 + 2 + 22 + 13 + 46 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809408 + 10.1007/s00403-023-02577-7 + 10.1007/s00403-023-02577-7 + + + + Geisler AN, Phillips GS, Barrios DM et al (2020) Immune checkpoint inhibitor-related dermatologic adverse events. J Am Acad Dermatol 83(5):1255–1268. https://doi.org/10.1016/j.jaad.2020.03.132 + + 10.1016/j.jaad.2020.03.132 + 32454097 + 7572894 + + + + Failla CM, Carbone ML, Fortes C, Pagnanelli G, D’Atri S (2019) Melanoma and vitiligo in: good company. Int J Mol Sci 20(22):5731. https://doi.org/10.3390/ijms20225731 + + 10.3390/ijms20225731 + 31731645 + 6888090 + + + + Lolli C, Medri M, Ricci M et al (2018) Vitiligo-like lesions in a patient treated with nivolumab for renal cell carcinoma. Medicine (Baltimore) 97(52):e13810. https://doi.org/10.1097/MD.0000000000013810 + + 10.1097/MD.0000000000013810 + 30593172 + + + + Liu RC, Consuegra G, Chou S, Fernandez Peñas P (2019) Vitiligo-like depigmentation in oncology patients treated with immunotherapies for nonmelanoma metastatic cancers. Clin Exp Dermatol 44(6):643–646. https://doi.org/10.1111/ced.13867 + + 10.1111/ced.13867 + 30618056 + + + + Uenami T, Hosono Y, Ishijima M et al (2017) Vitiligo in a patient with lung adenocarcinoma treated with nivolumab: a case report. Lung Cancer 109:42–44. https://doi.org/10.1016/j.lungcan.2017.04.019 + + 10.1016/j.lungcan.2017.04.019 + 28577948 + + + + Bulat V, Likic R, Bradic L, Speeckaert R, Azdajic MD (2021) Pembrolizumab-induced vitiligo in a patient with lung adenocarcinoma: a case report. Br J Clin Pharmacol 87(6):2614–2618. https://doi.org/10.1111/bcp.14663 + + 10.1111/bcp.14663 + 33217043 + + + + Kosche C, Mohindra N, Choi JN (2018) Vitiligo in a patient undergoing nivolumab treatment for non-small cell lung cancer. JAAD Case Rep 4(10):1042–1044. https://doi.org/10.1016/j.jdcr.2018.08.009 + + 10.1016/j.jdcr.2018.08.009 + 30456282 + 6232635 + + + + Rodríguez-Lomba E, Molina-López I, Suárez-Fernández R, Baniandrés-Rodríguez O (2018) Vitiligo-like lesions and immune checkpoint inhibition therapy: is it truly an adverse event exclusive to patients with melanoma? Clin Exp Dermatol 43(5):598–599. https://doi.org/10.1111/ced.13382 + + 10.1111/ced.13382 + 29333653 + + + + Hua C, Boussemart L, Mateus C et al (2016) Association of vitiligo with tumor response in patients with metastatic melanoma treated with pembrolizumab. JAMA Dermatol 152(1):45. https://doi.org/10.1001/jamadermatol.2015.2707 + + 10.1001/jamadermatol.2015.2707 + 26501224 + + + + Teulings H-E, Limpens J, Jansen SN et al (2015) Vitiligo-like depigmentation in patients with stage iii–iv melanoma receiving immunotherapy and its association with survival: a systematic review and meta-analysis. JCO 33(7):773–781. https://doi.org/10.1200/JCO.2014.57.4756 + + 10.1200/JCO.2014.57.4756 + + + + Freeman-keller M, Kim Y, Cronin H, Richards A, Gibney G, Weber JS (2016) Nivolumab in resected and unresectable metastatic melanoma: characteristics of immune-related adverse events and association with outcomes. Clin Cancer Res 22(4):886–894 + + 10.1158/1078-0432.CCR-15-1136 + 26446948 + + + + Villadolid J, Amin A (2015) Immune checkpoint inhibitors in clinical practice: update on management of immune-related toxicities. Transl Lung Cancer Res 4(5):560–575 + + 26629425 + 4630514 + + + + Quaglino P, Marenco F, Osella-Abate S et al (2010) Vitiligo is an independent favourable prognostic factor in stage III and IV metastatic melanoma patients: results from a single-institution hospital-based observational cohort study. Ann Oncol 21(2):409–414. https://doi.org/10.1093/annonc/mdp325 + + 10.1093/annonc/mdp325 + 19622589 + + + + Karri PV, Tahseen D, Patel AB (2020) Treatment of checkpoint inhibitor-induced vitiligo in a patient with metastatic renal cell cancer. Dermatitis. https://doi.org/10.1097/DER.0000000000000670 + + 10.1097/DER.0000000000000670 + + + + Grimes PE, Miller MM (2018) Vitiligo: patient stories, self-esteem, and the psychological burden of disease. Int J Womens Dermatol 4(1):32–37. https://doi.org/10.1016/j.ijwd.2017.11.005 + + 10.1016/j.ijwd.2017.11.005 + 29872674 + 5986114 + + + + Seneschal J, Harris JE, Le Poole IC, Passeron T, Speeckaert R, Boniface K (2021) Editorial: immunology of vitiligo. Front Immunol 12:711080 + + 10.3389/fimmu.2021.711080 + 34249018 + 8264751 + + + + Hodi FS, Chesney J, Pavlick AC et al (2016) Combined nivolumab and ipilimumab versus ipilimumab alone in patients with advanced melanoma: 2-year overall survival outcomes in a multicentre, randomised, controlled, phase 2 trial. Lancet Oncol 17:1558–1568. https://doi.org/10.1016/S1470-2045(16)30366-7 + + 10.1016/S1470-2045(16)30366-7 + 27622997 + 5630525 + + + + Larkin J, Chiarion-Sileni V, Gonzalez R et al (2019) Five-year survival with combined nivolumab and ipilimumab in advanced melanoma. N Engl J Med 381(16):1535–1546. https://doi.org/10.1056/NEJMoa1910836 + + 10.1056/NEJMoa1910836 + 31562797 + + + + Topalian SL, Sznol M, McDermott DF et al (2014) Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab. J Clin Oncol 32(10):1020–1030. https://doi.org/10.1200/JCO.2013.53.0105 + + 10.1200/JCO.2013.53.0105 + 24590637 + 4811023 + + + + Robert C, Schachter J, Long GV et al (2015) Pembrolizumab versus ipilimumab in advanced melanoma. N Engl J Med 372(26):2521–2532. https://doi.org/10.1056/NEJMoa1503093 + + 10.1056/NEJMoa1503093 + 25891173 + + + + Hamid O, Robert C, Daud A et al (2019) Five-year survival outcomes for patients with advanced melanoma treated with pembrolizumab in KEYNOTE-001. Ann Oncol 30(4):582–588. https://doi.org/10.1093/annonc/mdz011 + + 10.1093/annonc/mdz011 + 30715153 + 6503622 + + + + +
+ + + 36809409 + + 2023 + 02 + 22 + +
+ + 1432-069X + + + 2023 + Feb + 21 + + + Archives of dermatological research + Arch Dermatol Res + + Fractional carbon dioxide laser alone and as an assisted drug delivery for treatment of alopecia areata: a clinical, dermoscopic and immunohistochemical study. + 10.1007/s00403-023-02565-x + + Alopecia areata (AA) is a common cause of hair loss with no available universally successful treatment. Thus, new innovative treatments are urgently needed. This research aimed to evaluate the effectiveness of fractional carbon dioxide laser (FCL) alone or combined with triamcinolone acetonide (TA) solution, platelet-rich plasma (PRP), or vitamin D3 solution in treating AA. Sixty-four AA patients with 185 lesions were recruited and divided into four treatment groups. All patients received FCL either alone (group A, n = 19) or followed by topical TA (group B, n = 16) or PRP (group C, n = 15), or vitamin D3 solution (group D, n = 14). The response was assessed using Alopecia Areata Severity Index (AASI), MacDonald Hull and Norris grading, and trichoscopy. Histopathological features and immunohistochemical decorin expression were studied. All groups showed significant improvement in AASI compared to the baseline, with insignificant differences between them. Post-treatment, trichoscopic features of disease activity significantly decreased in all groups. Compared to control biopsies, both anagen follicles and decorin expression were significantly decreased in all pretreatment specimens. After treatment, all groups showed significantly increased anagen follicles and decorin expression compared to the baseline. Accordingly, FCL is an effective treatment for AA alone or combined with TA, PRP, or vitamin D3 solution. In AA, Decorin expression was downregulated, while enhanced expression following successful treatment occurred. This suggests the role of decorin in AA pathogenesis. However, further research is still recommended to clarify the exact role of decorin in AA pathogenesis and to investigate the therapeutic benefits of decorin-based therapy. + © 2023. The Author(s). + + + + Meguid + Azza Mahfouz Abdel + AMA + + Dermatology, Venereology and Andrology Department, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt. + + + + Ghazally + Alaa + A + + Dermatology, Venereology and Andrology Department, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt. + + + + Ahmed + Asmaa M + AM + + Pathology Department, Faculty of Medicine, Assiut University, Assiut, Egypt. + + + + Bakr + Radwa M + RM + + Dermatology, Venereology and Andrology Department, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt. radwabakr@aun.edu.eg. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Arch Dermatol Res + 8000462 + 0340-3696 + + IM + + Alopecia areata + Decorin + Fractional carbon dioxide laser + Platelet-rich plasma + Triamcinolone acetonide + Vitamin D3 solution + +
+ + + + 2022 + 12 + 22 + + + 2023 + 02 + 01 + + + 2022 + 12 + 22 + + + 2023 + 2 + 22 + 13 + 46 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809409 + 10.1007/s00403-023-02565-x + 10.1007/s00403-023-02565-x + + + + Abou-Taleb D, Abd El Hameed MA, Moubasher AE (2021) Psychological impact of alopecia areata on Egyptian patients. J Clin Exp Dermatol Res 12(5):1–4. https://doi.org/10.35248/2155-9554.21.12.568 + + 10.35248/2155-9554.21.12.568 + + + + Pratt CH et al (2017) Alopecia areata Nature reviews. Dis Primers 3:17011. https://doi.org/10.1038/nrdp.2017.11 + + 10.1038/nrdp.2017.11 + + + + Olayinka JJT, Richmond JM (2021) Immunopathogenesis of alopecia areata. Curr Res Immunol 2:7–11. https://doi.org/10.1016/j.crimmu.2021.02.001 + + 10.1016/j.crimmu.2021.02.001 + 35492401 + + + + Wadstein J, Thom E, Gadzhigoroeva A (2020) Integral roles of specific proteoglycans in hair growth and hair loss: mechanisms behind the bioactivity of proteoglycan replacement therapy with Nourkrin® with Marilex® in pattern hair loss and telogen effluvium. Dermatol Res Pract. https://doi.org/10.1155/2020/8125081 + + 10.1155/2020/8125081 + 32425997 + 7222612 + + + + Inui S, Itami S (2014) A newly discovered linkage between proteoglycans and hair biology: decorin acts as an anagen inducer. Exp Dermatol 23(8):547–548. https://doi.org/10.1111/exd.12471 + + 10.1111/exd.12471 + 24942290 + + + + Miyachi K et al (2018) Extracellular proteoglycan decorin maintains human hair follicle stem cells. 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+ + + 36809422 + + 2023 + 02 + 22 + +
+ + 1590-3478 + + + 2023 + Feb + 21 + + + Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology + Neurol Sci + + Patient and carer involvement in the formulation of research questions: findings from the Italian guideline on palliative care in adults with glioma. + 10.1007/s10072-023-06687-y + + In 2017, the European Association for Neuro-Oncology (EANO) published the guideline for palliative care (PC) in adults with glioma. The Italian Society of Neurology (SIN), the Italian Association for Neuro-Oncology (AINO), and the Italian Society for Palliative Care (SICP) joined forces to update and adapt this guideline to the Italian context and aimed to involve patients and carers in the formulation of the clinical questions. + During semi-structured interviews with glioma patients and focus group meetings (FGMs) with family carers of deceased patients, participants rated the importance of a set of pre-specified intervention topics, shared their experience, and suggested additional topics. Interviews and FGMs were audio-recorded, transcribed, coded, and analyzed (framework and content analysis). + We held 20 interviews and five FGMs (28 carers). Both parties considered the pre-specified topics as important, chiefly information/communication, psychological support, symptoms management, and rehabilitation. Patients aired the impact of focal neurological and cognitive deficits. Carers reported difficulties in dealing with patient's behavior and personality changes and appreciated the preservation of patient's functioning via rehabilitation. Both affirmed the importance of a dedicated healthcare path and patient's involvement in the decision-making process. Carers expressed the need to be educated and supported in their caregiving role. + Interviews and FGMs were well informative and emotionally challenging. Both parties confirmed the importance of the pre-specified topics, and carers suggested one additional topic: education/support to caregivers. Our findings strengthen the importance of a comprehensive care approach and of addressing the needs of both patients and their family carers. + © 2023. Fondazione Società Italiana di Neurologia. + + + + Veronese + Simone + S + http://orcid.org/0000-0002-9555-7252 + + Palliative Care and Research Department, Fondazione FARO, Turin, Italy. + + + + Bertocchi + Elisabetta + E + http://orcid.org/0000-0002-9595-6384 + + Palliative Care Unit, Azienda USL-IRCCS Di Reggio Emilia, Reggio Emilia, Italy. + + + + Lissoni + Barbara + B + + Hospice and Palliative Care Unit, Niguarda Hospital, Milan, Italy. + + + + Rudà + Roberta + R + http://orcid.org/0000-0001-9134-1537 + + Division of Neuro-Oncology, Dept of Neuroscience, City of Health and Science and University of Turin, Turin, Italy. + + + + Silvani + Antonio + A + http://orcid.org/0000-0002-4791-1042 + + Department of Neuro-Oncology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy. + + + + Simonetti + Giorgia + G + http://orcid.org/0000-0002-0064-5509 + + Department of Neuro-Oncology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy. + + + + Pisanello + Anna + A + + Unit of Neuro-Oncology, Azienda USL - IRCCS Di Reggio Emilia, Reggio Emilia, Italy. + + + + Ieraci + Sonia + S + + Psychology Unit, IRCCS-Regina Elena National Cancer Institute, Rome, Italy. + + + + Salmaggi + Andrea + A + http://orcid.org/0000-0001-6925-3434 + + Unit of Neurology, Presidio A. Manzoni, ASST Lecco, Lecco, Italy. + + + + Merli + Rossella + R + + Unit of Neurosurgery, ASST Papa Giovanni 23, Bergamo, Italy. + + + + Verza + Marina + M + + Associazione IRENE Onlus, Rome, Italy. + + + + De Panfilis + Ludovica + L + http://orcid.org/0000-0002-5509-7626 + + Bioethics Unit, Azienda USL - IRCCS Di Reggio Emilia, Reggio Emilia, Italy. + + + + Solari + Alessandra + A + http://orcid.org/0000-0001-9930-7579 + + Unit of Neuroepidemiology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133, Milan, Italy. Alessandra.Solari@istituto-besta.it. + + + + Pace + Andrea + A + http://orcid.org/0000-0002-9407-6916 + + Neuro-Oncology Unit, IRCCS-Regina Elena National Cancer Institute, Rome, Italy. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Italy + Neurol Sci + 100959175 + 1590-1874 + + IM + + Brain tumors + Consumer involvement + Gliomas + Palliative care + Practice guideline + Qualitative study + +
+ + + + 2023 + 01 + 30 + + + 2023 + 02 + 13 + + + 2023 + 2 + 22 + 13 + 47 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809422 + 10.1007/s10072-023-06687-y + 10.1007/s10072-023-06687-y + + + References + + Pace A, Dirven L, Koekkoek LAF, Golla H, Fleming J et al (2017) EANO guidelines for palliative care in adult glioma patients. Lancet Oncol 18(6):e330–e340 + + 10.1016/S1470-2045(17)30345-5 + 28593859 + + + + Radbruch L, De Lima L, Knaul F, Wenk R, Ali Z et al (2020) Redefining palliative care. A new consensus-based definition. J Pain Symptom Manage 60(4):754–764 + + 10.1016/j.jpainsymman.2020.04.027 + 32387576 + 8096724 + + + + Temel J, Greer JA, Muzikansky A, Gallagher ER, Admane S et al (2010) Early palliative care for patients with metastatic non–small-cell lung cancer. N Engl J Med 363(8):733–742 + + 10.1056/NEJMoa1000678 + 20818875 + + + + Committee on Standards for Developing Trustworthy Clinical Practice Guidelines, Graham R, Mancher M, Miller Wolman D, Greenfield S, Steinberg E, eds (2011) Clinical practice guidelines we can trust. Washington, DC: The National Academies Press. http://www.nationalacademies.org/hmd/Reports/2011/Clinical-Practice-Guidelines-We-Can-Trust.aspx . Accessed 5 Sept 2022 + + + Armstrong MJ, Rueda JD, Gronseth GS, Mullins CD (2017) Framework for enhancing clinical practice guidelines through continuous patient engagement. Health Expect 20(1):3–10 + + 10.1111/hex.12467 + 27115476 + + + + Armstrong MJ, Bloom JA (2017) Patient involvement in guidelines is poor five years after institute of medicine standards: review of guideline methodologies. Res Involv Engagem 3(1):19 + + 10.1186/s40900-017-0070-2 + 29062544 + 5623959 + + + + Brouwers MC et al (2017) Understanding optimal approaches to patient and caregiver engagement in the development of cancer practice guidelines: a mixed methods study. BMC Health Serv Res 17(1):186 + + 10.1186/s12913-017-2107-5 + 28279216 + 5345242 + + + + Köpke S, Giordano A, Veronese S, Rahn AC, Kleiter I et al (2019) Patient and caregiver involvement in the formulation of guideline questions: findings from the European Academy of Neurology guideline on palliative care of people with severe multiple sclerosis. Eur J Neurol 26(1):41–50 + + 10.1111/ene.13760 + 30035845 + + + + Solari A, Veronese S, Verde GD, De Panfilis L, Bertocchi E, et al. (2023) Health professional involvement in the formulation of research questions: findings from the Italian guideline on palliative care in adults with glioma. Neurol Sci 4. https://doi.org/10.1007/s10072-022-06593-9 + + + Tong A, Sainsbury P, Craig J (2007) Consolidated criteria for reporting qualitative research (COREQ): a 32- item checklist for interviews and focus groups. Int J Qual Health Care 19(6):349–357 + + 10.1093/intqhc/mzm042 + 17872937 + + + + Silverman D (2006) Interpreting qualitative data, 3rd edn. Sage, London + + + Kim C, Berta WB, Gagliardi AR (2021) Exploring approaches to identify, incorporate and report patient preferences in clinical guidelines: qualitative interviews with guideline developers. Patient Educ Couns 104:703–708 + + 10.1016/j.pec.2020.10.001 + 33059950 + + + + Halkett GKB, Lobb EA, Phillips JL, McDougall E et al (2023) Carer preparedness improved by providing a supportive educational intervention for carers of patients with high-grade glioma: RCT results. J Neuro-Oncol. https://doi.org/10.1007/s11060-023-04239-0 + + 10.1007/s11060-023-04239-0 + + + + Coolbrandt A, Sterckx W, Clement P, Borgenon S, Decruyenaere M et al (2015) Family caregivers of patients with a high-grade glioma: a qualitative study of their lived experience and needs related to professional care. Cancer Nurs 38(5):406–413 + + 10.1097/NCC.0000000000000216 + 25521908 + + + + Sterckx W, Coolbrandt A, Clement P, Borgenon S, Decruyenaere M et al (2015) Living with a high-grade glioma: a qualitative study of patients’ experiences and care needs. Eur J Oncol Nurs 19(4):383–390 + + 10.1016/j.ejon.2015.01.003 + 25697546 + + + + Piil K, Jakobsen J, Christensen KB, Juhler M, Guetterman TC et al (2018) Needs and preferences among patients with high-grade glioma and their caregivers - a longitudinal mixed methods study. Eur J Cancer Care 27(2):e12806.3 + + 10.1111/ecc.12806 + + + + +
+ + + 36809419 + + 2023 + 02 + 22 + +
+ + 1432-1971 + + + 2023 + Feb + 21 + + + Pediatric cardiology + Pediatr Cardiol + + A Preliminary Study of One Year Safety and Tolerability of Attention-Deficit/Hyperactivity Disorder Medications in Youth with Fontan Palliation or Heart Transplant. + 10.1007/s00246-023-03128-7 + + There are no published studies that examine the safety and tolerability of medication to treat attention-deficit/hyperactivity disorder (ADHD) in children with histories of Fontan palliation (Fontan) or heart transplant (HT), despite the high prevalence of ADHD in these populations. To address this gap, we examined the cardiac course, somatic growth, and incidence of side effects for one year after medication initiation amongst children with Fontan or HT and comorbid ADHD. The final sample comprised 24 children with Fontan (12 medication-treated, 12 control) and 20 children with HT (10 medication-treated, 10 control). Demographic, somatic growth (height and weight percentile-for age), and cardiac data (blood pressure, heart rate, results of 24 h Holter monitoring, electrocardiograms) were extracted from electronic medical records. Medication-treated and control subjects were matched by cardiac diagnosis (Fontan or HT), age, and sex. Nonparametric statistical tests were utilized to compare between- and within-group differences prior to, and one year post, medication initiation. There were no differences in somatic growth or cardiac data when comparing medication-treated participants to matched controls, regardless of cardiac diagnosis. Within the medication group, a statistically significant increase in blood pressure was observed, though the group average remained within clinically acceptable limits. While results are preliminary in nature due to our very limited sample size, our findings suggest that ADHD medications can be tolerated with minimal cardiac or somatic growth effects amongst complex cardiac patients. Our preliminary results favor treating ADHD with medication, which has considerable implications for long-term academic/employment outcomes and quality of life for this population. Close collaboration between pediatricians, psychologists, and cardiologists is essential to individualizing and optimizing interventions and outcomes for children with Fontan or HT. + © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. + + + + Jassal + Yasmine R + YR + + Children's Hospital Colorado, 13123 East 16Th Avenue, Aurora, CO, 80045, USA. Yasmine.jassal@childrenscolorado.org. + + + University of Colorado School of Medicine, Aurora, CO, USA. Yasmine.jassal@childrenscolorado.org. + + + + Slomowitz + Rebecca + R + + Children's Hospital Colorado, 13123 East 16Th Avenue, Aurora, CO, 80045, USA. + + + + Everitt + Melanie D + MD + + Children's Hospital Colorado, 13123 East 16Th Avenue, Aurora, CO, 80045, USA. + + + University of Colorado School of Medicine, Aurora, CO, USA. + + + + Christofferson + Elizabeth S + ES + + Children's Hospital Colorado, 13123 East 16Th Avenue, Aurora, CO, 80045, USA. + + + University of Colorado School of Medicine, Aurora, CO, USA. + + + + von Alvensleben + Johannes C + JC + + Children's Hospital Colorado, 13123 East 16Th Avenue, Aurora, CO, 80045, USA. + + + University of Colorado School of Medicine, Aurora, CO, USA. + + + + Di Maria + Michael + M + + Children's Hospital Colorado, 13123 East 16Th Avenue, Aurora, CO, 80045, USA. + + + University of Colorado School of Medicine, Aurora, CO, USA. + + + + Wolfe + Kelly R + KR + + Children's Hospital Colorado, 13123 East 16Th Avenue, Aurora, CO, 80045, USA. + + + University of Colorado School of Medicine, Aurora, CO, USA. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Pediatr Cardiol + 8003849 + 0172-0643 + + IM + + Attention-deficit/hyperactivity disorder + Congenital heart disease + Fontan palliation + Heart transplant + +
+ + + + 2022 + 11 + 14 + + + 2023 + 02 + 06 + + + 2023 + 2 + 22 + 13 + 47 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809419 + 10.1007/s00246-023-03128-7 + 10.1007/s00246-023-03128-7 + + + + Hoffman JL, Kaplan S (2002) The incidence of congenital heart disease. J Am Coll Cardiol 39(12):1890–1900 + + 10.1016/S0735-1097(02)01886-7 + 12084585 + + + + Oster M, Lee K, Honein M et al (2013) Temporal trends in survival for infants with critical congenital heart defects. Pediatr 131(5):e1502-1508 + + 10.1542/peds.2012-3435 + + + + d’Udekem Y, Iyengar AJ, Galati JC et al (2014) Redefining expectations of long-term survival after the Fontan procedure. Circulation 130(11):32–38 + + + Miatton M, de Wolf D, Francois K et al (2007) Neuropsychological performance in school-aged children with surgically corrected congenital heart disease. J Pediatr 151(1):73–78 + + 10.1016/j.jpeds.2007.02.020 + 17586194 + + + + Baum M, Freier MC, Freeman K et al (2004) Neuropsychological outcome of infant heart transplant recipients. J Pediatr 145(3):365–372 + + 10.1016/j.jpeds.2004.05.047 + 15343193 + + + + Polanczyk G, de Lima MS, Horta BL et al (2007) The worldwide prevalence of ADHD: a systematic review and metaregression analysis. Amer J Psychiatry 164(6):942–948 + + 10.1176/ajp.2007.164.6.942 + + + + Marino BS, Lipkin PH, Newburger JW et al (2012) Neurodevelopmental outcomes in children with congenital heart disease: evaluation and management. Circulation 126(9):1143–1172 + + 10.1161/CIR.0b013e318265ee8a + 22851541 + + + + Baum M, Freier MC, Chinnock E (2003) Neurodevelopmental outcome of solid organ transplantation in children. Pediatr Clin North Am 50(6):1493–1503 + + 10.1016/S0031-3955(03)00152-4 + 14710789 + + + + Hirsch JC, Jacobs ML, Andropoulos D et al (2012) Protecting the infant brain during cardiac surgery: a systematic review. Ann Thorac Surg 94(4):1365–1373 + + 10.1016/j.athoracsur.2012.05.135 + 23006704 + 4249676 + + + + Mahle WT, Clancy RR, Moss EM et al (2000) Neurodevelopmental and lifestyle assessment in school-aged and adolescent children with hypoplastic left heart syndrome. Pediatr 105:1082–1089 + + 10.1542/peds.105.5.1082 + + + + DeMaso DR, Calderon J, Taylor GA et al (2017) Psychiatric disorders in adolescents with single ventricle congenital heart disease. Pediatrics. https://doi.org/10.1542/peds.2016-2241 + + 10.1542/peds.2016-2241 + 28148729 + 5330395 + + + + Shillingford AJ, Glanzman MM, Ittenbach FR et al (2008) Inattention, hyperactivity, and school performance in a population of school-age children with complex congenital heart disease. Pediatrics 121:e759-767 + + 10.1542/peds.2007-1066 + 18381503 + + + + Wolfe KR, Kelly SL, Steinberg E et al (2020) Predictors of neuropsychological functioning and medication adherence in pediatric heart transplant recipients referred for neuropsychological evaluation. Pediatr Trasnplant 24:e13615 + + + Danielson ML, Bitsko RH, Ghandour RM et al (2016) Prevalence of parent-reported ADHD diagnosis and associated treatment among US children and adolescents. J Clin Child Adolesc Psychol 47(2):199–212 + + 10.1080/15374416.2017.1417860 + + + + Gutgesell H, Atkins D, Barst R et al (1999) AHA scientific statement: cardiovascular monitoring of children and adolescents receiving psychotropic drugs. Circulation 99:979–982 + + 10.1161/01.CIR.99.7.979 + 10027824 + + + + Batra AS, Alexander ME, Silka MJ (2011) Attention-deficit/hyperactivity disorder, stimulant therapy, and the patient with congenital heart disease: evidence and reason. Pediatr Cardiol 22:394–401 + + + Rajeh A, Amanullah S, Shivakumar K et al (2017) Interventions in ADHD: a comparative review of stimulant medications and behavioral therapies. Asian J Psychiatr 25:131–135 + + 10.1016/j.ajp.2016.09.005 + 28262134 + + + + Findling RL, Biederman J, Wilens TE et al (2005) Short- and long-term cardiovascular effects of mixed amphetamine salts extended release in children. J Pediatr 147:348–354 + + 10.1016/j.jpeds.2005.03.014 + 16182674 + + + + Torres-Acosta N, O’Keefe JH, O’Keefe CL et al (2020) Cardiovascular effects of ADHD therapies: JACC review topic of the week. J Am Coll Cardiol 76(7):858–866 + + 10.1016/j.jacc.2020.05.081 + 32792083 + + + + Childress AC, Spender T, Lopez F et al (2008) Efficacy and safety of dexmethylphenidate extended-release capsules administered once daily to children with attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharm 19(4):351–361 + + 10.1089/cap.2009.0007 + + + + Rapport MD, Moffitt C (2002) Attention deficit/hyperactivity disorder and methylphenidate. a review of height/weight, cardiovascular, and complaint side effects. Clin Psychol Rev 22(8):1107–1131 + + 10.1016/S0272-7358(02)00129-0 + 12436807 + + + + Medoff-Cooper B, Ravishankar C (2013) Nutrition and growth in congenital heart disease: a challenge in children. Curr Opin Cardiol 28(2):122–129 + + 10.1097/HCO.0b013e32835dd005 + 23370229 + + + + Peterson RE, Perens GS, Alejos JC et al (2008) Growth and weight gain of prepubertal children after cardiac transplantation. Pediatr Transplant 12(4):436–441 + + 10.1111/j.1399-3046.2007.00826.x + 18466430 + + + + Liptzin DR, Di Maria MV, Younoszai A et al (2018) Pulmonary screening in subjects after the fontan procedure. J Pediatr 199:140–143 + + 10.1016/j.jpeds.2018.03.050 + 29747936 + + + + American Academy of Pediatrics (2004) Steering committee on quality improvement and management. classifying recommendations for clinical practice guidelines. Pediatrics 144:874–877 + + + Donner R, Michaels MA, Ambrosini PJ (2007) Cardiovascular effects of mixed amphetamine salts extended release in the treatment of school-aged children with attention-deficit/hyperactivity disorder. Biol Psychiatry 61(5):706–712 + + 10.1016/j.biopsych.2006.05.002 + 16899230 + + + + United States Census Bureau. QuickFacts: Colorado. Updated July 1, 2021. Accessed May 5, 2022. https://www.census.gov/quickfacts/CO + + + National Institutes of Health. Blood pressure levels for boys and girls by age and height percentile. Accessed February 1, 2022. https://www.nhlbi.nih.gov/files/docs/guidelines/child_tbl.pdf + + + Fleming S, Thompson M, Stevens R et al (2011) Normal ranges of heart rate and respiratory rate in children from birth to 18 years: a systematic review of observational studies. The Lancet 377(9770):1011–1018 + + 10.1016/S0140-6736(10)62226-X + + + + Cox DJ, Merkel L, Kovatchev B et al (2000) Effect of stimulant medication on driving performance of young adults with attention-deficit hyperactivity disorder. J Nerv Ment Dis 188:230–234 + + 10.1097/00005053-200004000-00006 + 10790000 + + + + Biederman J, Wilens TE, Mick E et al (1998) Does attention-deficit hyperactivity disorder impact the developmental course of drug and alcohol abuse and dependence? Bioi Psychiatry 44(4):269–273 + + 10.1016/S0006-3223(97)00406-X + + + + Cox DJ, Humphrey JW, Merkel RL et al (2004) Controlled-release methylphenidate improves attention during on-road driving by adolescents with attention-deficit/hyperactivity disorder. J Am Board Fam Pract 17(4):235–239 + + 10.3122/jabfm.17.4.235 + 15243010 + + + + Biederman J (2003) Pharmacotherapy for attention-deficit/hyperactivity disorder (ADHD) decreases the risk for substance abuse: findings from a longitudinal follow-up of youths with and without ADHD. J Clin Psychiatry 64(suppl 11):3–8 + + 14529323 + + + + Schermann H, Gurel R, Ankory R et al (2018) Lower risk of fractures under methylphenidate treatment for ADHD: a dose-response effect. J Orthope Res 36(12):3328–3333 + + 10.1002/jor.24129 + + + + Shaw M, Hodgkins P, Caci H et al (2012) A systematic review and analysis of long-term outcomes in attention-deficit/hyperactivity disorder: effects of treatment and non-treatment. BMC Med 10(99):1–15 + + + Rychik J, Atz A, Celemajer DS et al (2019) Evaluation and management of the child and adult with fontan circulation: a scientific statement from the American Heart association. Circulation 140:234–284 + + 10.1161/CIR.0000000000000696 + + + + +
+ + + 36809420 + + 2023 + 02 + 22 + +
+ + 1590-3478 + + + 2023 + Feb + 21 + + + Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology + Neurol Sci + + MRI and steroid-responsive encephalopathy associated with autoimmune thyroiditis: first report of conus medullaris involvement and literature review of the known neuroimaging profiles. + 10.1007/s10072-023-06642-x + + Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT) is a rare but potentially reversible autoimmune encephalopathy. The most frequent neuroimaging correlates are normal brain MRI or non-specific white matter hyperintensities. + We present the first description of conus medullaris involvement, also providing an extensive review of MRI patterns described so far. + Our results show that in less than 30% of cases, it is possible to find focal SREAT neuroanatomical correlates. Among these, T2w/FLAIR temporal hyperintensities are the most frequent, followed by basal ganglia/thalamic and brainstem involvement, respectively. + Unfortunately, spinal cord investigation is an uncommon practice in the diagnostic approach of encephalopathies, thus neglecting potential pathological lesions of the medulla spinalis. In our opinion, the extension of the MRI study to the cervical, thoracic, and lumbosacral regions may allow finding new, and hopefully specific, anatomical correlates. + © 2023. Fondazione Società Italiana di Neurologia. + + + + Cipriano + Lorenzo + L + http://orcid.org/0000-0002-5651-4970 + + Department of Advanced Medical and Surgical Sciences, University of Campania "L. Vanvitelli", Naples, Italy. lorenzo.cipriano@studenti.unicampania.it. + + + + Miele + Giuseppina + G + + Department of Advanced Medical and Surgical Sciences, University of Campania "L. Vanvitelli", Naples, Italy. + + + + Ugga + Lorenzo + L + + Department of Advanced Biomedical Sciences, University of Naples "Federico II", Naples, Italy. + + + + Abbadessa + Gianmarco + G + + Department of Advanced Medical and Surgical Sciences, University of Campania "L. Vanvitelli", Naples, Italy. + + + + Caranci + Ferdinando + F + + Department of Precision Medicine, University of Campania Luigi Vanvitelli, Naples, Italy. + + + + Bonavita + Simona + S + + Department of Advanced Medical and Surgical Sciences, University of Campania "L. Vanvitelli", Naples, Italy. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Italy + Neurol Sci + 100959175 + 1590-1874 + + IM + + Conus medullaris + Encephalopathy + Hashimoto + SREAT + +
+ + + + 2022 + 10 + 31 + + + 2023 + 01 + 22 + + + 2023 + 2 + 22 + 13 + 47 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809420 + 10.1007/s10072-023-06642-x + 10.1007/s10072-023-06642-x + + + + Gini B, Laura L, Riccardo C et al (2008) Novel autoantigens recognized by CSF IgG from Hashimoto’s encephalitis revealed by a proteomic approach. J Neuroimmunol 196:153–158. https://doi.org/10.1016/j.jneuroim.2008.02.015 + + 10.1016/j.jneuroim.2008.02.015 + 18407358 + + + + Laurent C, Capron J, Quillerou B et al (2016) Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT): characteristics, treatment and outcome in 251 cases from the literature. Autoimmun Rev 15:1129–1133. https://doi.org/10.1016/J.AUTREV.2016.09.008 + + 10.1016/J.AUTREV.2016.09.008 + 27639840 + + + + Ferracci F, Moretto G, Candeago RM et al (2003) Antithyroid antibodies in the CSF. Neurol 60:712–714. https://doi.org/10.1212/01.WNL.0000048660.71390.C6 + + 10.1212/01.WNL.0000048660.71390.C6 + + + + Kelley BP, Patel SC, Marin HL et al (2017) Autoimmune encephalitis: pathophysiology and imaging review of an overlooked diagnosis. Am J Neuroradiol 38:1070–1078. https://doi.org/10.3174/AJNR.A5086 + + 10.3174/AJNR.A5086 + 28183838 + 7960083 + + + + Graus F, Titulaer MJ, Balu R et al (2016) A clinical approach to diagnosis of autoimmune encephalitis. Lancet Neurol 15:391–404. https://doi.org/10.1016/S1474-4422(15)00401-9 + + 10.1016/S1474-4422(15)00401-9 + 26906964 + 5066574 + + + + +
+ + + 36809418 + + 2023 + 02 + 22 + +
+ + 1292-895X + + 46 + 2 + + 2023 + Feb + 21 + + + The European physical journal. E, Soft matter + Eur Phys J E Soft Matter + + Experimental realization of constant current device using hydrogen bond ferroelectric liquid crystals. + + 7 + + 10.1140/epje/s10189-023-00264-z + + Electrical, thermal, and spectral characterizations of ferroelectric liquid crystal obtained from the precursors namely camphoric acid and heptyloxy benzoic acid abbreviated as CA + 7BAO. This mesogen exhibits two phases smectic C* and smectic G* in its exothermic run. DSC thermograms reveals the phase transition temperatures and enthalpy values of those phases. The spectral information recorded through Fourier transform infrared spectroscope reveals the possession of hydrogen bond. An interesting feature of this work lies in realizing the constant current device with variation to both temperature as well as potential. The same observation shall be utilized for the sensitive biomedical instruments where the current rating above few µA increment do have significant effect. Furthermore, the research work also reveals the information about the linearity of the thermo-electric graph with respect to phase transition temperatures. Thermoelectric Plot. + © 2023. The Author(s), under exclusive licence to EDP Sciences, SIF and Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Kishor + Muchenedi Hari + MH + http://orcid.org/0000-0002-2005-7296 + + Department of Analytics, Vellore Institute of Technology, Vellore, 632014, India. mharikishor@gmail.com. + + + + Madhu Mohan + M L N + MLN + + Liquid Crystal Research Laboratory, Bannari Amman Institute of Technology, Sathyamangalam, 638401, India. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + France + Eur Phys J E Soft Matter + 101126530 + 1292-8941 + + IM +
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+ + 1590-3478 + + + 2023 + Feb + 21 + + + Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology + Neurol Sci + + The first MS attack after methanol toxicity in a young man: a case report. + 10.1007/s10072-023-06689-w + + + Ebadi + Zahra + Z + + Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. + + + + Asadollahzade + Elnaz + E + + Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. + + + + Ghadiri + Fereshteh + F + + Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. + + + + Naser Moghadasi + Abdorreza + A + http://orcid.org/0000-0002-8598-0911 + + Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. abdorrezamoghadasi@gmail.com. + + + + eng + + Letter + + + 2023 + 02 + 21 + +
+ + Italy + Neurol Sci + 100959175 + 1590-1874 + + IM +
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+ + 1741-0444 + + + 2023 + Feb + 21 + + + Medical & biological engineering & computing + Med Biol Eng Comput + + Colorectal cancer lymph node metastasis prediction with weakly supervised transformer-based multi-instance learning. + 10.1007/s11517-023-02799-x + + Lymph node metastasis examined by the resected lymph nodes is considered one of the most important prognostic factors for colorectal cancer (CRC). However, it requires careful and comprehensive inspection by expert pathologists. To relieve the pathologists' burden and speed up the diagnostic process, in this paper, we develop a deep learning system with the binary positive/negative labels of the lymph nodes to solve the CRC lymph node classification task. The multi-instance learning (MIL) framework is adopted in our method to handle the whole slide images (WSIs) of gigapixels in size at once and get rid of the labor-intensive and time-consuming detailed annotations. First, a transformer-based MIL model, DT-DSMIL, is proposed in this paper based on the deformable transformer backbone and the dual-stream MIL (DSMIL) framework. The local-level image features are extracted and aggregated with the deformable transformer, and the global-level image features are obtained with the DSMIL aggregator. The final classification decision is made based on both the local and the global-level features. After the effectiveness of our proposed DT-DSMIL model is demonstrated by comparing its performance with its predecessors, a diagnostic system is developed to detect, crop, and finally identify the single lymph nodes within the slides based on the DT-DSMIL and the Faster R-CNN model. The developed diagnostic model is trained and tested on a clinically collected CRC lymph node metastasis dataset composed of 843 slides (864 metastasis lymph nodes and 1415 non-metastatic lymph nodes), achieving the accuracy of 95.3% and the area under the receiver operating characteristic curve (AUC) of 0.9762 (95% confidence interval [CI]: 0.9607-0.9891) for the single lymph node classification. As for the lymph nodes with micro-metastasis and macro-metastasis, our diagnostic system achieves the AUC of 0.9816 (95% CI: 0.9659-0.9935) and 0.9902 (95% CI: 0.9787-0.9983), respectively. Moreover, the system shows reliable diagnostic region localizing performance: the model can always identify the most likely metastases, no matter the model's predictions or manual labels, showing great potential in avoiding false negatives and discovering incorrectly labeled slides in actual clinical use. + © 2023. The Author(s). + + + + Tan + Luxin + L + + Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Pathology, Peking University Cancer Hospital & Institute, Beijing, 100142, China. + + + + Li + Huan + H + + Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Pathology, Peking University Cancer Hospital & Institute, Beijing, 100142, China. + + + + Yu + Jinze + J + + Beijing Advanced Innovation Center for Big Data and Brain Computing, Beihang University, Beijing, 100191, China. + + + School of Computer Science and Engineering, Beihang University, Beijing, 100191, China. + + + Shenyuan Honors College, Beihang University, Beijing, 100191, China. + + + + Zhou + Haoyi + H + + Beijing Advanced Innovation Center for Big Data and Brain Computing, Beihang University, Beijing, 100191, China. + + + College of Software, Beihang University, Beijing, 100191, China. + + + + Wang + Zhi + Z + + Blot Info & Tech (Beijing) Co. Ltd, Beijing, China. + + + + Niu + Zhiyong + Z + + Blot Info & Tech (Beijing) Co. Ltd, Beijing, China. niuzhiyong@blothealth.com. + + + + Li + Jianxin + J + + Beijing Advanced Innovation Center for Big Data and Brain Computing, Beihang University, Beijing, 100191, China. lijx@act.buaa.edu.cn. + + + School of Computer Science and Engineering, Beihang University, Beijing, 100191, China. lijx@act.buaa.edu.cn. + + + + Li + Zhongwu + Z + http://orcid.org/0000-0003-3440-9077 + + Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Pathology, Peking University Cancer Hospital & Institute, Beijing, 100142, China. zhwuli@hotmail.com. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Med Biol Eng Comput + 7704869 + 0140-0118 + + IM + + Colorectal cancer + Computer-aided diagnosing + Deep learning + Lymph node metastasis + Multi-instance learning + Vision transformer + Whole slide image + +
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+ + 1590-3478 + + + 2023 + Feb + 21 + + + Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology + Neurol Sci + + Autonomic dysfunction-dominant phenotype in a Chinese family with biallelic GGC repeat expansions in NOTCH2NLC. + 10.1007/s10072-023-06688-x + + The GGC repeat expansions in the NOTCH2NLC gene are associated with multiple neurodegenerative disorders. Herein, we report the clinical phenotype in a family with biallelic GGC expansions in NOTCH2NLC. Autonomic dysfunction was a prominent clinical manifestation in three genetically confirmed patients without dementia, parkinsonism, and cerebellar ataxia for > 12 years. A 7-T brain magnetic resonance imaging in two patients revealed a change in the small cerebral veins. The biallelic GGC repeat expansions may not modify the disease progression in neuronal intranuclear inclusion disease. Autonomic dysfunction-dominant may expand the clinical phenotype of NOTCH2NLC. + © 2023. Fondazione Società Italiana di Neurologia. + + + + Chen + Bin + B + + Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No.119 South 4Th Ring West Road, Fengtai District, Beijing, 100070, China. + + + China National Clinical Research Center for Neurological Diseases, Beijing, China. + + + + Jing + Jing + J + + Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No.119 South 4Th Ring West Road, Fengtai District, Beijing, 100070, China. + + + China National Clinical Research Center for Neurological Diseases, Beijing, China. + + + Tiantan Nenroimaging Center of Excellence, Beijing, China. + + + + Dong + Gehong + G + + Department of Pathology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. + + + + Shi + Yuzhi + Y + + Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No.119 South 4Th Ring West Road, Fengtai District, Beijing, 100070, China. + + + China National Clinical Research Center for Neurological Diseases, Beijing, China. + + + + Zhang + Cuiping + C + + Department of Ultrastructural Pathology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. + + + + Zhang + Yumei + Y + + China National Clinical Research Center for Neurological Diseases, Beijing, China. + + + Monogenic Disease Research Center for Neurological Disorders, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. + + + + Wang + An + A + + Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No.119 South 4Th Ring West Road, Fengtai District, Beijing, 100070, China. + + + China National Clinical Research Center for Neurological Diseases, Beijing, China. + + + + Tai + Hongfei + H + + Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No.119 South 4Th Ring West Road, Fengtai District, Beijing, 100070, China. + + + China National Clinical Research Center for Neurological Diseases, Beijing, China. + + + + Niu + Songtao + S + + Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No.119 South 4Th Ring West Road, Fengtai District, Beijing, 100070, China. + + + China National Clinical Research Center for Neurological Diseases, Beijing, China. + + + + Wang + Xingao + X + + Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No.119 South 4Th Ring West Road, Fengtai District, Beijing, 100070, China. + + + China National Clinical Research Center for Neurological Diseases, Beijing, China. + + + + Pan + Hua + H + + Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No.119 South 4Th Ring West Road, Fengtai District, Beijing, 100070, China. + + + China National Clinical Research Center for Neurological Diseases, Beijing, China. + + + + Zhang + Zaiqiang + Z + http://orcid.org/0000-0002-0053-3451 + + Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No.119 South 4Th Ring West Road, Fengtai District, Beijing, 100070, China. ttyy0142011@126.com. + + + China National Clinical Research Center for Neurological Diseases, Beijing, China. ttyy0142011@126.com. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Italy + Neurol Sci + 100959175 + 1590-1874 + + IM + + Autonomic dysfunction + Biallelic GGC repeat expansions + Deep medullary veins + NOTCH2NLC + Neuronal intranuclear inclusion disease + +
+ + + + 2022 + 08 + 28 + + + 2023 + 02 + 12 + + + 2023 + 2 + 22 + 13 + 47 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809423 + 10.1007/s10072-023-06688-x + 10.1007/s10072-023-06688-x + + + + Sone J, Mori K, Inagaki T et al (2016) Clinicopathological features of adult-onset neuronal intranuclear inclusion disease. Brain 139:3170–3186 + + 10.1093/brain/aww249 + 27797808 + 5382941 + + + + Sone J, Mitsuhashi S, Fujita A et al (2019) Long-read sequencing identifies GGC repeat expansions in NOTCH2NLC associated with neuronal intranuclear inclusion disease. Nat Genet 51:1215–1221 + + 10.1038/s41588-019-0459-y + 31332381 + + + + Ogasawara M, Iida A, Kumutpongpanich T et al (2020) CGG expansion in NOTCH2NLC is associated with oculopharyngodistal myopathy with neurological manifestations. Acta Neuropathol Commun 8:204 + + 10.1186/s40478-020-01084-4 + 33239111 + 7690190 + + + + Yu J, Deng J, Guo X et al (2021) The GGC repeat expansion in NOTCH2NLC is associated with oculopharyngodistal myopathy type 3. Brain 144:1819–1832 + + 10.1093/brain/awab077 + 33693509 + 8320266 + + + + Tian Y, Zhou L, Gao J et al (2022) Clinical features of NOTCH2NLC-related neuronal intranuclear inclusion disease. J Neurol Neurosurg Psychiatry 93:1289–1298 + + 36150844 + + + + Kameyama S, Mizuguchi T, Doi H et al (2022) Patients with biallelic GGC repeat expansions in NOTCH2NLC exhibiting a typical neuronal intranuclear inclusion disease phenotype. Genomics 114:110469 + + 10.1016/j.ygeno.2022.110469 + 36041634 + + + + Liang H, Wang B, Li Q et al (2020) Clinical and pathological features in adult-onset NIID patients with cortical enhancement. J Neurol 267:3187–3198 + + 10.1007/s00415-020-09945-7 + 32535679 + + + + Fang P, Yu Y, Yao S et al (2020) Repeat expansion scanning of the NOTCH2NLC gene in patients with multiple system atrophy. Ann Clin Transl Neurol 7:517–526 + + 10.1002/acn3.51021 + 32250060 + 7187708 + + + + Zannolli R, Gilman S, Rossi S et al (2002) Hereditary neuronal intranuclear inclusion disease with autonomic failure and cerebellar degeneration. Arch Neurol 59:1319–1326 + + 10.1001/archneur.59.8.1319 + 12164731 + + + + Nakamura M, Ueki S, Kubo M et al (2018) Two cases of sporadic adult-onset neuronal intranuclear inclusion disease preceded by urinary disturbance for many years. J Neurol Sci 392:89–93 + + 10.1016/j.jns.2018.07.012 + 30031993 + + + + +
+ + + 36809424 + + 2023 + 02 + 22 + +
+ + 1590-3478 + + + 2023 + Feb + 21 + + + Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology + Neurol Sci + + Correction to: The effects of exercise intervention on cognition and motor function in stroke survivors: a systematic review and meta‑analysis. + 10.1007/s10072-023-06691-2 + + + Li + Wenxuan + W + http://orcid.org/0000-0003-1105-2220 + + School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, China. + + + + Luo + Ziyan + Z + + School of Nursing, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. + + + + Jiang + Jieting + J + + School of Nursing, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. + + + + Li + Kunpeng + K + + School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. xyfyli@163.com. + + + + Wu + Caiqin + C + http://orcid.org/0000-0002-9420-8958 + + School of Nursing, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. yuwuchina@aliyun.com. + + + + eng + + Published Erratum + + + 2023 + 02 + 21 + +
+ + Italy + Neurol Sci + 100959175 + 1590-1874 + + IM + + + Neurol Sci. 2023 Feb 14;: + 36781567 + + +
+ + + + 2023 + 2 + 22 + 13 + 47 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809424 + 10.1007/s10072-023-06691-2 + 10.1007/s10072-023-06691-2 + + +
+ + + 36809426 + + 2023 + 02 + 22 + +
+ + 1619-7089 + + + 2023 + Feb + 21 + + + European journal of nuclear medicine and molecular imaging + Eur J Nucl Med Mol Imaging + + Clinical prospective study of Gallium 68 (68Ga)-labeled fibroblast-activation protein inhibitor PET/CT in the diagnosis of biliary tract carcinoma. + 10.1007/s00259-023-06137-z + + This study is to investigate the [68Ga]Ga-DOTA-FAPI PET/CT diagnosis performance in biliary tract carcinoma (BTC) and analyze the association between [68Ga]Ga-DOTA-FAPI PET/CT and clinical indexes. + A prospective study (NCT05264688) was performed between January 2022 and July 2022. Fifty participants were scanned using [68Ga]Ga-DOTA-FAPI and [18F]FDG PET/CT and acquired pathological tissue. We employed the Wilcoxon signed-rank test to compare the uptake of [68Ga]Ga-DOTA-FAPI and [18F]FDG, and the McNemar test was used to compare the diagnostic efficacy between the two tracers. Spearman or Pearson correlation was used to assess the association between [68 Ga]Ga-DOTA-FAPI PET/CT and clinical indexes. + In total, 47 participants (mean age 59.09 ± 10.98 [range 33-80 years]) were evaluated. The [68Ga]Ga-DOTA-FAPI detection rate was greater than [18F]FDG in primary tumors (97.62% vs. 85.71%), nodal metastases (90.05% vs. 87.06%), and distant metastases (100% vs. 83.67%). The uptake of [68Ga]Ga-DOTA-FAPI was higher than [18F]FDG in primary lesions (intrahepatic cholangiocarcinoma, 18.95 ± 7.47 vs. 11.86 ± 0.70, p = 0.001; extrahepatic cholangiocarcinoma, 14.57 ± 6.16 vs. 8.80 ± 4.74, p = 0.004), abdomen and pelvic cavity nodal metastases (6.91 ± 6.56 vs. 3.94 ± 2.83, p < 0.001), and distant metastases (pleural, peritoneum, omentum, and mesentery, 6.37 ± 4.21 vs. 4.50 ± 1.96, p = 0.01; bone, 12.15 ± 6.43 vs. 7.51 ± 4.54, p = 0.008). There was a significant correlation between [68Ga]Ga-DOTA-FAPI uptake and fibroblast-activation protein (FAP) expression (Spearman r = 0.432, p = 0.009), carcinoembryonic antigen (CEA) (Pearson r = 0.364, p = 0.012), and platelet (PLT) (Pearson r = 0.35, p = 0.016). Meanwhile, a significant relationship between [68Ga]Ga-DOTA-FAPI metabolic tumor volume and carbohydrate antigen199 (CA199) (Pearson r = 0.436, p = 0.002) was confirmed. + [68Ga]Ga-DOTA-FAPI had a higher uptake and sensitivity than [18F]FDG in the diagnosis of BTC primary and metastatic lesions. The correlation between [68Ga]Ga-DOTA-FAPI PET/CT indexes and FAP expression, CEA, PLT, and CA199 were confirmed. + clinicaltrials.gov: NCT 05,264,688. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Jinghua + Li + L + + Department of Hepatobiliary and Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China. + + + Clinical Medicine Research Center for Minimally Invasive Procedure of Hepatobiliary &, Pancreatic Diseases of Hubei Province, Wuhan, Hubei, China. + + + + Kui + Xu + X + + Department of Nuclear Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China. + + + + Deliang + Guo + G + + Department of Hepatobiliary and Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China. + + + Clinical Medicine Research Center for Minimally Invasive Procedure of Hepatobiliary &, Pancreatic Diseases of Hubei Province, Wuhan, Hubei, China. + + + + Bo + Liao + L + + Department of Hepatobiliary and Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China. + + + Clinical Medicine Research Center for Minimally Invasive Procedure of Hepatobiliary &, Pancreatic Diseases of Hubei Province, Wuhan, Hubei, China. + + + + Qian + Zhu + Z + + Department of Hepatobiliary and Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China. + + + Clinical Medicine Research Center for Minimally Invasive Procedure of Hepatobiliary &, Pancreatic Diseases of Hubei Province, Wuhan, Hubei, China. + + + + Haitao + Wang + W + + Department of Hepatobiliary and Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China. + + + Clinical Medicine Research Center for Minimally Invasive Procedure of Hepatobiliary &, Pancreatic Diseases of Hubei Province, Wuhan, Hubei, China. + + + + Yaqun + Jiang + J + + Clinical Medicine Research Center for Minimally Invasive Procedure of Hepatobiliary &, Pancreatic Diseases of Hubei Province, Wuhan, Hubei, China. + + + Department of Nuclear Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China. + + + + Dongde + Wu + W + + Department of Hepatobiliary and Pancreatic Surgery, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. + + + + Xigang + Xia + X + + Department of Hepatobiliary Surgery, Jingzhou Central Hospital, Jingzhou, Hubei, China. + + + + Ping + Jiang + J + + Department of Hepatobiliary and Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China. + + + Clinical Medicine Research Center for Minimally Invasive Procedure of Hepatobiliary &, Pancreatic Diseases of Hubei Province, Wuhan, Hubei, China. + + + + Shengli + Tang + T + + Department of Hepatobiliary and Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China. + + + Clinical Medicine Research Center for Minimally Invasive Procedure of Hepatobiliary &, Pancreatic Diseases of Hubei Province, Wuhan, Hubei, China. + + + + Zhiyong + Yang + Y + + Department of Hepatobiliary and Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China. + + + Clinical Medicine Research Center for Minimally Invasive Procedure of Hepatobiliary &, Pancreatic Diseases of Hubei Province, Wuhan, Hubei, China. + + + + Yueming + He + H + + Department of Hepatobiliary and Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China. + + + Clinical Medicine Research Center for Minimally Invasive Procedure of Hepatobiliary &, Pancreatic Diseases of Hubei Province, Wuhan, Hubei, China. + + + + Zhonglin + Zhang + Z + + Department of Hepatobiliary and Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China. zhonglinzhang@whu.edu.cn. + + + Clinical Medicine Research Center for Minimally Invasive Procedure of Hepatobiliary &, Pancreatic Diseases of Hubei Province, Wuhan, Hubei, China. zhonglinzhang@whu.edu.cn. + + + + Yong + He + H + + Clinical Medicine Research Center for Minimally Invasive Procedure of Hepatobiliary &, Pancreatic Diseases of Hubei Province, Wuhan, Hubei, China. heyong@znhospital.cn. + + + Department of Nuclear Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China. heyong@znhospital.cn. + + + + Yufeng + Yuan + Y + + Department of Hepatobiliary and Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China. yuanyf1971@whu.edu.cn. + + + Clinical Medicine Research Center for Minimally Invasive Procedure of Hepatobiliary &, Pancreatic Diseases of Hubei Province, Wuhan, Hubei, China. yuanyf1971@whu.edu.cn. + + + TaiKang Center for Life and Medical Sciences, Wuhan University, Wuhan, Hubei, China. yuanyf1971@whu.edu.cn. + + + + eng + + + 2021BCA114 + Key Research and Development Program of Hubei Province + + + + WJ2021M255 + Research Fund of the Health Commission of Hubei Province + + + + ZLYNXM202004 + Cancer research and translational platform project of Zhongnan Hospital of Wuhan University + + + + + Journal Article + + + 2023 + 02 + 21 + +
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+ + + 36809428 + + 2023 + 02 + 22 + +
+ + 1590-1262 + + 28 + 1 + + 2023 + Feb + 21 + + + Eating and weight disorders : EWD + Eat Weight Disord + + Predictors of caregiver burden before starting family-based treatment for adolescent anorexia nervosa and associations with weight gain during treatment. + + 21 + + 10.1007/s40519-023-01553-4 + + Caregivers play a pivotal role in the success of family-based treatment (FBT) for anorexia nervosa (AN). Caregiver burden is frequently demonstrated in eating disorders (EDs) and may impact FBT outcomes. This study examined factors associated with caregiver burden before starting FBT and whether pre-treatment caregiver burden was associated with weight gain during FBT. + Participants included 114 adolescents with AN or atypical AN (mean age = 15.6 years, SD = 1.4) and a primary caregiver (87.6% mothers) who received FBT in the United States. Before starting treatment, participants completed self-report measures of caregiver burden (via the Eating Disorder Symptom Impact Scale), caregiver anxiety, caregiver depression, and ED symptoms. Clinical characteristics and percentage of target goal weight (%TGW) at FBT session 1 and 3 and 6 months after starting treatment were obtained via retrospective chart review. Hierarchical regressions examined predictors of caregiver burden before FBT initiation. Associations between pre-treatment caregiver burden and %TGW gain at 3 and 6 months after starting FBT were assessed with hierarchical regressions. + Caregiver anxiety (p < 0.001), family history of EDs (p = 0.028), adolescent mental health treatment history (p = 0.024), and ED symptoms (p = 0.042) predicted caregiver burden before starting FBT. Pre-treatment caregiver burden was not associated with %TGW gain at 3 or 6 months. Males demonstrated less %TGW gain than females at 3 months (p = 0.010) and 6 months (p = 0.012). + Proactively evaluating caregiver burden before starting FBT is suggested. Providing recommendations and/or referrals for identified caregiver vulnerabilities could indirectly impact FBT progress. Males in FBT could require longer courses of treatment and extra vigilance to this demographic is suggested. + Level III, case-control analytic study. + © 2023. The Author(s). + + + + Matthews + Abigail + A + http://orcid.org/0000-0002-1548-2589 + + Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. abigail.matthews@cchmc.org. + + + Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. abigail.matthews@cchmc.org. + + + + Bruening + Amanda B + AB + + Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. + + + Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. + + + + Aarnio-Peterson + Claire M + CM + + Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. + + + Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. + + + + Kramer + Rachel + R + + Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Eat Weight Disord + 9707113 + 1124-4909 + + IM + + Adolescents + Anorexia nervosa + Caregiver burden + Family-based treatment + +
+ + + + 2022 + 10 + 18 + + + 2023 + 02 + 10 + + + 2023 + 2 + 22 + 13 + 47 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809428 + 10.1007/s40519-023-01553-4 + 10.1007/s40519-023-01553-4 + + + + Lock J, Le Grange D (2019) Family-based treatment: where are we and where should we be going to improve recovery in child and adolescent eating disorders. Int J Eat Disord 52:481–487. https://doi.org/10.1002/eat.22980 + + 10.1002/eat.22980 + 30520532 + + + + Couturier J, Kimber M, Szatmari P (2013) Efficacy of family-based treatment for adolescents with eating disorders: a systematic review and meta-analysis. Int J Eat Disord 46:3–11. https://doi.org/10.1002/eat.22042 + + 10.1002/eat.22042 + 22821753 + + + + Crow SJ, Nyman JA (2004) The cost-effectiveness of anorexia nervosa treatment. 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Int J Eat Disord 44:731–734. https://doi.org/10.1002/eat.20877 + + 10.1002/eat.20877 + 22072411 + + + + Rienecke RD, Lebow J, Lock J, Le Grange D (2017) Family profiles of expressed emotion in adolescent patients with anorexia nervosa and their parents. J Clin Child Adolesc Psychol 46:428–436. https://doi.org/10.1080/15374416.2015.1030755 + + 10.1080/15374416.2015.1030755 + 25945418 + + + + Monteleone AM, Pellegrino F, Coratto G, Carfagno M, Hilbert A et al (2022) Treatment of eating disorders: a systematic meta-review of meta-analyses and network meta-analyses. Neurosci Biobehav Rev 142:104857. https://doi.org/10.1016/j.neubiorev.2022.104857 + + 10.1016/j.neubiorev.2022.104857 + 36084848 + + + + Zabala MJ, Macdonald P, Treasure J (2009) Appraisal of caregiving burden, expressed emotion and psychological distress in families of people with eating disorders: a systematic review. Eur Eat Disord Rev 17(5):338–349. https://doi.org/10.1002/erv.925 + + 10.1002/erv.925 + 19367608 + + + + Duclos J, Dorard G, Berthoz S, Curt F, Faucher S, Falissard B, Godart N (2014) Expressed emotion in anorexia nervosa: what is inside the “black box”? Compr Psychiatry 55:71–79. https://doi.org/10.1016/j.comppsych.2013.10.002 + + 10.1016/j.comppsych.2013.10.002 + 24199888 + + + + Kyriacou O, Treasure J, Schmidt U (2008) Expressed emotion in eating disorders assessed via self-report: an examination of factors associated with expressed emotion in carers of people with anorexia nervosa in comparison to control families. Int J Eat Disord 41:37–46. https://doi.org/10.1002/eat.20469 + + 10.1002/eat.20469 + 17922532 + + + + Padierna A, Martín J, Aguirre U, González N, Muñoz P, Quintana JM (2013) Burden of caregiving amongst family caregivers of patients with eating disorders. Soc Psychiatry Psychiatr Epidemiol 48:151–161. https://doi.org/10.1007/s00127-012-0525-6 + + 10.1007/s00127-012-0525-6 + 22722535 + + + + Coomber K, King RM (2012) Coping strategies and social support as predictors and mediators of eating disorder carer burden and psychological distress. Soc Psychiatry Psychiatr Epidemiol 47:789–796. https://doi.org/10.1007/s00127-011-0384-6 + + 10.1007/s00127-011-0384-6 + 21516510 + + + + Kyriacou O, Treasure J, Schmidt U (2008) Understanding how parents cope with living with someone with anorexia nervosa: modelling the factors that are associated with carer distress. Int J Eat Disord 41:233–242. https://doi.org/10.1002/eat.20488 + + 10.1002/eat.20488 + 18008326 + + + + Matthews A, Lenz KR, Peugh J, Copps EC, Peterson CM (2018) Caregiver burden and illness perceptions in caregivers of medically hospitalized youth with anorexia nervosa. Eat Behav 29:14–18. https://doi.org/10.1016/j.eatbeh.2018.01.003 + + 10.1016/j.eatbeh.2018.01.003 + 29413819 + + + + Whitney J, Haigh R, Weinman J, Treasure J (2007) Caring for people with eating disorders: factors associated with psychological distress and negative caregiving appraisals in carers of people with eating disorders. Br J Clin Psychol 46:413–428. https://doi.org/10.1348/014466507X173781 + + 10.1348/014466507X173781 + 17535529 + + + + Stefanini MC, Troiani MR, Caselli M, Dirindelli P, Lucarelli S, Caini S, Martinetti MG (2019) Living with someone with an eating disorder: factors affecting the caregivers’ burden. Eat Weight Disord 24(6):1209–1214. https://doi.org/10.1007/s40519-018-0480-7 + + 10.1007/s40519-018-0480-7 + 29368292 + + + + Macdonald P, Rhind C, Hibbs R, Goddard E, Raenker S, Todd G, Schmidt U, Treasure J (2014) Carers’ assessment, skills, and information sharing (CASIS) trial: a qualitative study of the experiential perspective of caregivers and patients. Eur Eat Disord Rev 22:430–438. https://doi.org/10.1002/erv.2320 + + 10.1002/erv.2320 + 25267532 + + + + Sepúlveda AR, Graell M, Berbel E, Anastasiadou D, Botella J, Carrobles JA, Morandé G (2012) Factors associated with emotional well-being in primary and secondary caregivers of patients with eating disorders. Eur Eat Disord Rev 20:e78-84. https://doi.org/10.1002/erv.1118 + + 10.1002/erv.1118 + 21796734 + + + + Khalsa SS, Portnoff LC, McCurdy-McKinnon D, Feusner JD (2017) What happens after treatment? A systematic review of relapse, remission, and recovery in anorexia nervosa. J Eat Disord 14:20. https://doi.org/10.1186/s40337-017-0145-3 + + 10.1186/s40337-017-0145-3 + + + + Anastasiadou D, Medina-Pradas C, Sepulveda AR, Treasure J (2014) A systematic review of family caregiving in eating disorders. 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+ + + 36809429 + + 2023 + 02 + 22 + +
+ + 1559-0291 + + + 2023 + Feb + 21 + + + Applied biochemistry and biotechnology + Appl Biochem Biotechnol + + Survey of Acetylation for Thermoanaerobacter tengcongensis. + 10.1007/s12010-023-04361-9 + + Non-histone protein acetylation is involved in key cellular processes both in eukaryotes and prokaryotes. Acetylation in bacteria is used to modify proteins involved in metabolism and allow the bacteria to adapt to their environment. TTE (Thermoanaerobacter tengcongensis) is an anaerobic, thermophilic saccharolytic bacterium that grows at extreme temperature range between 50 and 80 ℃. The annotated TTE proteome contains less than 3000 proteins. We analyzed the proteome and acetylome of TTE using 2DLC-MS/MS (2-dimensional liquid chromatography mass spectrum). We evaluated the ability of mass spectrometry technology to cover a relatively small proteome as much as possible. And we also observed wide spread of acetylation in TTE, which changed under different temperatures. A total of 2082 proteins were identified, which accounts for about 82% of the database. A total of 2050 (~ 98%) proteins were quantified in at least one culture condition and 1818 proteins were quantified in all 4 conditions. The result also consisted 3457 acetylation sites corresponding to 827 distinct proteins, which covered 40% of the proteins identified. Bioinformatics analysis reported that proteins related to replication, recombination, repair, and extracellular structure cell wall biogenesis had more than half members acetylated, while energy production, carbohydrate transport, and metabolism related proteins were least acetylated. Our result suggested that acetylation affects the ATP-related energy metabolism and energy-dependent biosynthesis process. Comparing the enzymes related with lysine acetylation and acetyl-CoA (acetyl-coenzyme A) metabolism, we suggested that the acetylation of TTE took a non-enzymatic mechanism and affected by abundance of acetyl-CoA. + © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. + + + + Yao + Jun + J + + Department of Chemistry, Shanghai Stomatological Hospital & Institutes of Biomedical Sciences, Fudan University, Shanghai, 200433, China. + + + + Wang + Ze-Ning + ZN + + Department of Chemistry, Shanghai Stomatological Hospital & Institutes of Biomedical Sciences, Fudan University, Shanghai, 200433, China. + + + + Liu + Hang + H + + Department of Chemistry, Shanghai Stomatological Hospital & Institutes of Biomedical Sciences, Fudan University, Shanghai, 200433, China. + + + + Jin + Hong + H + + Department of Chemistry, Shanghai Stomatological Hospital & Institutes of Biomedical Sciences, Fudan University, Shanghai, 200433, China. jinhong@fudan.edu.cn. + + + + Zhang + Yang + Y + + Department of Chemistry, Shanghai Stomatological Hospital & Institutes of Biomedical Sciences, Fudan University, Shanghai, 200433, China. zhangyang@fudan.edu.cn. + + + + eng + + + 2021YFF0703702 + National Key R&D Program of China + + + + 32070605 + National Natural Science Foundation of China + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Appl Biochem Biotechnol + 8208561 + 0273-2289 + + IM + + Acetylation + Proteome + Thermoanaerobacter tengcongensis + +
+ + + + 2023 + 01 + 10 + + + 2023 + 2 + 22 + 13 + 47 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809429 + 10.1007/s12010-023-04361-9 + 10.1007/s12010-023-04361-9 + + + + Narita, T., Weinert, B. T., & Choudhary, C. (2019). Functions and mechanisms of non-histone protein acetylation. Nature Reviews Molecular Cell Biology, 20, 156–174. + + 10.1038/s41580-018-0081-3 + 30467427 + + + + James, A. M., Hoogewijs, K., Logan, A., Hall, A. R., Ding, S., Fearnley, I. M., & Murphy, M. P. (2017). Non-enzymatic N-acetylation of lysine residues by acetylCoA often occurs via a proximal S-acetylated thiol intermediate sensitive to glyoxalase II. Cell Reports, 18, 2105–2112. + + 10.1016/j.celrep.2017.02.018 + 28249157 + + + + Drazic, A., Myklebust, L. M., Ree, R., & Arnesen, T. (2016). The world of protein acetylation. Biochimica Et Biophysica Acta-Proteins and Proteomics, 1864, 1372–1401. + + 10.1016/j.bbapap.2016.06.007 + + + + Shvedunova, M., & Akhtar, A. (2022). 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+ + + 36809425 + + 2023 + 02 + 22 + +
+ + 1619-7089 + + + 2023 + Feb + 21 + + + European journal of nuclear medicine and molecular imaging + Eur J Nucl Med Mol Imaging + + The role of [18F]-DCFPyL PET/MRI radiomics for pathological grade group prediction in prostate cancer. + 10.1007/s00259-023-06136-0 + + To evaluate the diagnostic accuracy of [18F]-DCFPyL PET/MRI radiomics for the prediction of pathological grade group in prostate cancer (PCa) in therapy-naïve patients. + Patients with confirmed or suspected PCa, who underwent [18F]-DCFPyL PET/MRI (n = 105), were included in this retrospective analysis of two prospective clinical trials. Radiomic features were extracted from the segmented volumes following the image biomarker standardization initiative (IBSI) guidelines. Histopathology obtained from systematic and targeted biopsies of the PET/MRI-detected lesions was the reference standard. Histopathology patterns were dichotomized as ISUP GG 1-2 vs. ISUP GG ≥ 3 categories. Different single-modality models were defined for feature extraction, including PET- and MRI-derived radiomic features. The clinical model included age, PSA, and lesions' PROMISE classification. Single models, as well as different combinations of them, were generated to calculate their performances. A cross-validation approach was used to evaluate the internal validity of the models. + All radiomic models outperformed the clinical models. The best model for grade group prediction was the combination of PET + ADC + T2w radiomic features, showing sensitivity, specificity, accuracy, and AUC of 0.85, 0.83, 0.84, and 0.85, respectively. The MRI-derived (ADC + T2w) features showed sensitivity, specificity, accuracy, and AUC of 0.88, 0.78, 0.83, and 0.84, respectively. PET-derived features showed 0.83, 0.68, 0.76, and 0.79, respectively. The baseline clinical model showed 0.73, 0.44, 0.60, and 0.58, respectively. The addition of the clinical model to the best radiomic model did not improve the diagnostic performance. The performances of MRI and PET/MRI radiomic models as per the cross-validation scheme yielded an accuracy of 0.80 (AUC = 0.79), whereas clinical models presented an accuracy of 0.60 (AUC = 0.60). + The combined [18F]-DCFPyL PET/MRI radiomic model was the best-performing model and outperformed the clinical model for pathological grade group prediction, indicating a complementary value of the hybrid PET/MRI model for non-invasive risk stratification of PCa. Further prospective studies are required to confirm the reproducibility and clinical utility of this approach. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Basso Dias + Adriano + A + http://orcid.org/0000-0003-4761-8708 + + Joint Department of Medical Imaging, University Medical Imaging Toronto (UMIT), University Health Network, Mount Sinai Hospital & Women's College Hospital; University of Toronto, Toronto, ON, Canada. Adriano.BassoDias@uhn.ca. + + + + Mirshahvalad + Seyed Ali + SA + http://orcid.org/0000-0003-2271-9764 + + Joint Department of Medical Imaging, University Medical Imaging Toronto (UMIT), University Health Network, Mount Sinai Hospital & Women's College Hospital; University of Toronto, Toronto, ON, Canada. + + + + Ortega + Claudia + C + + Joint Department of Medical Imaging, University Medical Imaging Toronto (UMIT), University Health Network, Mount Sinai Hospital & Women's College Hospital; University of Toronto, Toronto, ON, Canada. + + + + Perlis + Nathan + N + + Division of Urology, Department of Surgery, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. + + + + Berlin + Alejandro + A + + Department of Radiation Oncology, Princess Margaret Cancer Center, University Health Network & University of Toronto, Toronto, ON, Canada. + + + + van der Kwast + Theodorus + T + + Laboratory Medicine Program, University Health Network, Toronto, ON, Canada. + + + + Ghai + Sangeet + S + + Joint Department of Medical Imaging, University Medical Imaging Toronto (UMIT), University Health Network, Mount Sinai Hospital & Women's College Hospital; University of Toronto, Toronto, ON, Canada. + + + + Jhaveri + Kartik + K + + Joint Department of Medical Imaging, University Medical Imaging Toronto (UMIT), University Health Network, Mount Sinai Hospital & Women's College Hospital; University of Toronto, Toronto, ON, Canada. + + + + Metser + Ur + U + + Joint Department of Medical Imaging, University Medical Imaging Toronto (UMIT), University Health Network, Mount Sinai Hospital & Women's College Hospital; University of Toronto, Toronto, ON, Canada. + + + + Haider + Masoom + M + + Joint Department of Medical Imaging, University Medical Imaging Toronto (UMIT), University Health Network, Mount Sinai Hospital & Women's College Hospital; University of Toronto, Toronto, ON, Canada. + + + + Avery + Lisa + L + + Department of Biostatistics, Princess Margaret Cancer Centre, Toronto, ON, Canada. + + + + Veit-Haibach + Patrick + P + + Joint Department of Medical Imaging, University Medical Imaging Toronto (UMIT), University Health Network, Mount Sinai Hospital & Women's College Hospital; University of Toronto, Toronto, ON, Canada. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Eur J Nucl Med Mol Imaging + 101140988 + 1619-7070 + + IM + + PET/MRI + Prostate + Radiomics + +
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+ + 1559-0291 + + + 2023 + Feb + 21 + + + Applied biochemistry and biotechnology + Appl Biochem Biotechnol + + 9-Tricosene Containing Blend of Volatiles Produced by Serratia sp. NhPB1 Isolated from the Pitcher Plant Provide Plant Protection Against Pythium aphanidermatum. + 10.1007/s12010-023-04352-w + + Plant-associated bacteria exhibit diverse chemical means to protect plants from the pathogens. The present study has been conducted to evaluate the volatile-mediated antifungal activity of Serratia sp. NhPB1 isolated from the pitcher plant against the notorious pathogen Pythium aphanidermatum. The study has also evaluated the protective effect of NhPB1 on Solanum lycopersicum and Capsicum annuum leaves and fruits against P. aphanidermatum. From the results, NhPB1 was found to have remarkable activity against the tested pathogen. The isolate was also found to impart disease protection in selected plants as evidenced by the morphological changes. Here, the leaves and fruits of S. lycopersicum and C. annuum control which were treated with the uninoculated LB and distilled water were found to have the presence of P. aphanidermatum growth with lesions and decaying of tissues. However, the NhPB1-treated plants did not show any symptoms of fungal infection. This could further be confirmed by the microscopical examination of tissues by propidium iodide staining. Here, the normal architecture of leaf and fruit tissues could be observed in the NhPB1-treated group, but the tissue invasion by P. aphanidermatum was observed in the control group which further confirms the promises of selected bacteria for biocontrol applications. + © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. + + + + R + Aswani + A + + School of Biosciences, Mahatma Gandhi University, Kottayam, Kerala, India, 686560. + + + + Das + Soumya + S + + Department of Zoology, KE College, Mannanam, Kottayam, India, 686561. + + + + Theresa + Mary + M + + School of Biosciences, Mahatma Gandhi University, Kottayam, Kerala, India, 686560. + + + + K S + Sebastian + S + + Department of Zoology, Government College, Kottayam, India, 686013. + + + + Mathew + Jyothis + J + + School of Biosciences, Mahatma Gandhi University, Kottayam, Kerala, India, 686560. + + + + E K + Radhakrishnan + R + http://orcid.org/0000-0003-2688-701X + + School of Biosciences, Mahatma Gandhi University, Kottayam, Kerala, India, 686560. radhakrishnanek@mgu.ac.in. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Appl Biochem Biotechnol + 8208561 + 0273-2289 + + IM + + Capsicum annuum + Plant-associated bacteria + Pythium aphanidermatum + Serratia sp. + Solanum lycopersicum + +
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Plant growth promotion by volatile organic compounds produced by Bacillus subtilis SYST2. Frontiers in Microbiology, 8, 51–57. https://doi.org/10.3389/fmicb.2017.00171 + + 10.3389/fmicb.2017.00171 + 28223976 + 5293759 + + + + Ubaid, J. M., Hussein, H. M., & Hameed, I. H. (2016). Analysis of bioactive compounds of tribolium castaneum and evaluation of anti-bacterial activity. International Journal of Pharmaceutical and Clinical Research, 8, 1192–1198. + + + Varsha, K. K., Devendra, L., Shilpa, G., Priya, S., Pandey, A., & Nampoothiri, K. M. (2015). 2,4-Di-tert-butyl phenol as the antifungal, antioxidant bioactive purified from a newly isolated Lactococcus sp. International Journal of Food Microbiology, 211, 44–50. https://doi.org/10.1016/j.ijfoodmicro.2015.06.025 + + 10.1016/j.ijfoodmicro.2015.06.025 + 26164257 + + + + Walters, D. R., Walker, R. L., & Walker, K. C. (2003). Lauric acid exhibits antifungal activity against plant pathogenic fungi. Journal of Phytopathology, 151, 228–230. https://doi.org/10.1046/j.1439-0434.2003.00713.x + + 10.1046/j.1439-0434.2003.00713.x + + + + Wang, C., Wang, Z., Qiao, X., Li, Z., Li, F., Chen, M., Wang, Y., Huang, Y., & Cui, H. (2013). Antifungal activity of volatile organic compounds from Streptomyces alboflavus TD-1. FEMS Microbiology Letters, 341, 45–51. https://doi.org/10.1111/1574-6968.12088 + + 10.1111/1574-6968.12088 + 23351181 + + + + Weise, T., Thürmer, A., Brady, S., Kai, M., Daniel, R., Gottschalk, G., & Piechulla, B. (2014). VOC emission of various Serratia species and isolates and genome analysis of Serratia plymuthica 4Rx13. FEMS Microbiology Letters, 352, 45–53. https://doi.org/10.1111/1574-6968.12359 + + 10.1111/1574-6968.12359 + 24341572 + + + + Yu, T., Chen, J., Lu, H., & Zheng, X. (2009). Indole-3-acetic acid improves postharvest biological control of blue mold rot of apple by Cryptococcus laurentii. Phytopathology®, 99, 258–264. https://doi.org/10.1094/PHYTO-99-3-0258 + + 10.1094/PHYTO-99-3-0258 + 19203278 + + + + +
+ + + 36809431 + + 2023 + 02 + 22 + +
+ + 1432-1084 + + + 2023 + Feb + 21 + + + European radiology + Eur Radiol + + The added value of [68Ga]Ga-DOTA-FAPI-04 PET/CT in pancreatic cancer: a comparison to [18F]F-FDG. + 10.1007/s00330-023-09445-y + + We aimed to compare the diagnostic and prognostic performance of [68Ga]Ga-DOTA-FAPI-04 and [18F]FDG PET/CT in pancreatic cancer. + This single-center retrospective study enrolled 51 patients who underwent [68Ga]Ga-DOTA-FAPI-04 and [18F]FDG PET/CT. The final diagnosis on PET/CT images was verified by histopathology or 1-year follow-up. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of [18F]FDG and [68Ga]Ga-DOTA-FAPI-04 PET/CT were calculated to compare the diagnostic efficacy. Progression-free survival (PFS) was the endpoint for the survival analysis. Twenty-six patients were eligible for the Kaplan-Meier survival analysis using a log-rank test. And multivariate analysis including age, sex, stage, CA199 level, and SUVmax of [18F]FDG and [68Ga]Ga-DOTA-FAPI-04 was also performed. Two-tailed p < 0.05 was considered statistically significant. + [68Ga]Ga-DOTA-FAPI-04 showed a higher sensitivity than [18F]FDG for detecting primary tumor (100% vs. 95.0%), metastatic lymph nodes (96.2% vs. 61.5%), and distant metastases (100% vs. 84.0%) (p < 0.0001, respectively). For [68Ga]Ga-DOTA-FAPI-04, the tumor-to-liver background ratio (TLBR) of liver metastases was higher (5.7 ± 3.2 vs. 3.2 ± 1.3, p < 0.0001). Furthermore, SUVmax > 14.9 on [68Ga]Ga-DOTA-FAPI-04 was significantly associated with PFS rates (chi-square = 12.05, p = 0.001). The Cox regression analysis showed that SUVmax of [68Ga]Ga-DOTA-FAPI-04 was an independent prognostic factor for PFS (p = 0.001; hazard ratio, 8.877). + [68Ga]Ga-DOTA-FAPI-04 PET/CT showed a higher sensitivity and accuracy than [18F]FDG PET/CT in diagnosing pancreatic cancer and might have an independent prognostic value for pancreatic cancer patients. + • [68Ga]Ga-DOTA-FAPI-04 PET/CT had a higher sensitivity and accuracy in detecting primary tumors, metastatic lymph nodes, and distant metastases than [18F]FDG PET/CT. • SUVmax > 14.9 on [68Ga]Ga-DOTA-FAPI-04 PET/CT before chemotherapy was significantly associated with progress-free status rates (chi-square = 12.05, p = 0.001) in pancreatic cancer patients. + © 2023. The Author(s), under exclusive licence to European Society of Radiology. + + + + Liu + Qiufang + Q + + Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, 200032, People's Republic of China. + + + Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, People's Republic of China. + + + Shanghai Engineering Research Center of Molecular Imaging Probes, Shanghai, 200032, People's Republic of China. + + + Key Laboratory of Nuclear Physics and Ion-Beam Application (MOE), Fudan University, Shanghai, 200433, People's Republic of China. + + + + Shi + Si + S + + Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, People's Republic of China. + + + Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, People's Republic of China. + + + + Liu + Shuai + S + + Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, 200032, People's Republic of China. + + + Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, People's Republic of China. + + + Shanghai Engineering Research Center of Molecular Imaging Probes, Shanghai, 200032, People's Republic of China. + + + Key Laboratory of Nuclear Physics and Ion-Beam Application (MOE), Fudan University, Shanghai, 200433, People's Republic of China. + + + + Xu + Xiaoping + X + + Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, 200032, People's Republic of China. + + + Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, People's Republic of China. + + + Shanghai Engineering Research Center of Molecular Imaging Probes, Shanghai, 200032, People's Republic of China. + + + Key Laboratory of Nuclear Physics and Ion-Beam Application (MOE), Fudan University, Shanghai, 200433, People's Republic of China. + + + + Hu + Silong + S + + Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, 200032, People's Republic of China. + + + Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, People's Republic of China. + + + Shanghai Engineering Research Center of Molecular Imaging Probes, Shanghai, 200032, People's Republic of China. + + + Key Laboratory of Nuclear Physics and Ion-Beam Application (MOE), Fudan University, Shanghai, 200433, People's Republic of China. + + + + Zhang + Ji + J + + Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, 200032, People's Republic of China. + + + Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, People's Republic of China. + + + Shanghai Engineering Research Center of Molecular Imaging Probes, Shanghai, 200032, People's Republic of China. + + + Key Laboratory of Nuclear Physics and Ion-Beam Application (MOE), Fudan University, Shanghai, 200433, People's Republic of China. + + + + Wang + Chunmei + C + + Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, 200032, People's Republic of China. + + + Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, People's Republic of China. + + + Shanghai Engineering Research Center of Molecular Imaging Probes, Shanghai, 200032, People's Republic of China. + + + Key Laboratory of Nuclear Physics and Ion-Beam Application (MOE), Fudan University, Shanghai, 200433, People's Republic of China. + + + + Yu + Xianjun + X + + Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, People's Republic of China. yuxianjun@fudanpci.org. + + + Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, People's Republic of China. yuxianjun@fudanpci.org. + + + + Song + Shaoli + S + http://orcid.org/0000-0003-2544-7522 + + Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, 200032, People's Republic of China. shaoli-song@163.com. + + + Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, People's Republic of China. shaoli-song@163.com. + + + Shanghai Engineering Research Center of Molecular Imaging Probes, Shanghai, 200032, People's Republic of China. shaoli-song@163.com. + + + Key Laboratory of Nuclear Physics and Ion-Beam Application (MOE), Fudan University, Shanghai, 200433, People's Republic of China. shaoli-song@163.com. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Eur Radiol + 9114774 + 0938-7994 + + IM + + Diagnosis + Pancreatic cancer + Prognosis + [18F]FDG + [68Ga]Ga-DOTA-FAPI-04 + +
+ + + + 2022 + 07 + 02 + + + 2023 + 01 + 18 + + + 2023 + 01 + 08 + + + 2023 + 2 + 22 + 13 + 47 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809431 + 10.1007/s00330-023-09445-y + 10.1007/s00330-023-09445-y + + + + Tempero MA (2019) NCCN guidelines updates: pancreatic cancer. J Natl Compr Canc Netw 17:603–605 + + 31117041 + + + + Arnold M, Rutherford MJ, Bardot A et al (2019) Progress in cancer survival, mortality, and incidence in seven high-income countries 1995–2014 (ICBP SURVMARK-2): a population-based study. Lancet Oncol 20:1493–1505 + + 10.1016/S1470-2045(19)30456-5 + 31521509 + 6838671 + + + + Siegel RL (2020) Miller KD (2020) Cancer statistics. CA Cancer J Clin 70:7–30 + + 10.3322/caac.21590 + 31912902 + + + + Scialpi M, Reginelli A, D’Andrea A et al (2016) Pancreatic tumors imaging: an update. Int J Surg 1:S142-155 + + 10.1016/j.ijsu.2015.12.053 + + + + Daamen LA, Groot VP, Goense L et al (2018) The diagnostic performance of CT versus FDG PET-CT for the detection of recurrent pancreatic cancer: a systematic review and meta-analysis. Eur J Radiol 106:128–136 + + 10.1016/j.ejrad.2018.07.010 + 30150034 + + + + Wartski M, Sauvanet A (2019) 18F-FDG PET/CT in pancreatic adenocarcinoma: a role at initial imaging staging? Diagn Interv Imaging 100:735–741 + + 10.1016/j.diii.2019.07.006 + 31402332 + + + + Biffi G, Tuveson DA (2021) Diversity and biology of cancer-associated fibroblasts. Physiol Rev 101:147–176 + + 10.1152/physrev.00048.2019 + 32466724 + + + + Sahai E, Astsaturov I (2020) A framework for advancing our understanding of cancer-associated fibroblasts. Nat Rev Cancer 20:174–186 + + 10.1038/s41568-019-0238-1 + 31980749 + 7046529 + + + + Kratochwil C, Flechsig P, Lindner T et al (2019) (68)Ga-FAPI PET/CT: tracer uptake in 28 different kinds of cancer. J Nucl Med 60:801–805 + + 10.2967/jnumed.119.227967 + 30954939 + 6581228 + + + + Chen H, Pang Y, Li J et al (2022) Comparison of [(68)Ga]Ga-FAPI and [(18)F]FDG uptake in patients with gastric signet-ring-cell carcinoma: a multicenter retrospective study. Eur Radiol 33:1329–1341 + + 10.1007/s00330-022-09084-9 + 35976396 + + + + Chen S, Chen Z, Zou G et al (2022) Accurate preoperative staging with [(68)Ga]Ga-FAPI PET/CT for patients with oral squamous cell carcinoma: a comparison to 2-[(18)F]FDG PET/CT. Eur Radiol 32:6070–6079 + + 10.1007/s00330-022-08686-7 + 35352157 + + + + Coto-Llerena M, Ercan C, Kancherla V et al (2020) High expression of FAP in colorectal cancer is associated with angiogenesis and immunoregulation processes. Front Oncol 10:979 + + 10.3389/fonc.2020.00979 + 32733792 + 7362758 + + + + Hessmann E, Buchholz SM, Demir IE et al (2020) Microenvironmental determinants of pancreatic cancer. Physiol Rev 100:1707–1751 + + 10.1152/physrev.00042.2019 + 32297835 + + + + Elyada E, Bolisetty M, Laise P et al (2019) Cross-species single-cell analysis of pancreatic ductal adenocarcinoma reveals antigen-presenting cancer-associated fibroblasts. Cancer Discov 9:1102–1123 + + 10.1158/2159-8290.CD-19-0094 + 31197017 + 6727976 + + + + Yin Z, Dong C, Jiang K et al (2019) Heterogeneity of cancer-associated fibroblasts and roles in the progression, prognosis, and therapy of hepatocellular carcinoma. J Hematol Oncol 12:1–9 + + 10.1186/s13045-019-0782-x + + + + Röhrich M, Naumann P, Giesel FL et al (2020) Impact of (68)Ga-FAPI-PET/CT imaging on the therapeutic management of primary and recurrent pancreatic ductal adenocarcinomas. J Nucl Med 62:779–786 + + 10.2967/jnumed.120.253062 + 33097632 + + + + Zhang Z, Jia G, Pan G et al (2022) Comparison of the diagnostic efficacy of (68) Ga-FAPI-04 PET/MR and (18)F-FDG PET/CT in patients with pancreatic cancer. Eur J Nucl Med Mol Imaging 49:2877–2888 + + 10.1007/s00259-022-05729-5 + 35243518 + + + + Xu D, Wang J, Liu T et al (2021) Quantitative definitions of pain, CA19-9, and tumor size as high-risk features of resectable pancreatic cancer: a single-center retrospective cohort study. Gland Surg 10:770–779 + + 10.21037/gs-20-877 + 33708559 + 7944065 + + + + Wu Z, Zhao P, Wang Z et al (2022) Adjusting CA19-9 values with clinical stage and bilirubin to better predict survival of resectable pancreatic cancer patients: 5-year-follow-up of a single center. Front Oncol 12 + + + Pang Y, Zhao L (2021) Comparison of (68)Ga-FAPI and (18)F-FDG uptake in gastric, duodenal, and colorectal cancers. Radiology 298:393–402 + + 10.1148/radiol.2020203275 + 33258746 + + + + Fan C, Guo W, Su G et al (2021) widespread metastatic gastric signet-ring cell carcinoma shown by 68Ga-FAPI PET/CT. Clin Nucl Med 46:e78–e79 + + 10.1097/RLU.0000000000003245 + 32804764 + + + + Guo W, Pang Y, Yao L et al (2020) Imaging fibroblast activation protein in liver cancer: a single-center post hoc retrospective analysis to compare [(68)Ga]Ga-FAPI-04 PET/CT versus MRI and [(18)F]-FDG PET/CT. Eur J Nucl Med Mol Imaging 48:1604–1617 + + 10.1007/s00259-020-05095-0 + 33179149 + + + + Pang Y, Zhao L, Shang Q et al (2021) Positron emission tomography and computed tomography with [(68)Ga]Ga-fibroblast activation protein inhibitors improves tumor detection and staging in patients with pancreatic cancer. Eur J Nucl Med Mol Imaging 49:1322–1337 + + 10.1007/s00259-021-05576-w + 34651226 + + + + Sandberg TP, Stuart M, Oosting J et al (2019) Increased expression of cancer-associated fibroblast markers at the invasive front and its association with tumor-stroma ratio in colorectal cancer. BMC Cancer 19:284 + + 10.1186/s12885-019-5462-2 + 30922247 + 6440123 + + + + Liao Y, Ni Y, He R et al (2013) Clinical implications of fibroblast activation protein-α in non-small cell lung cancer after curative resection: a new predictor for prognosis. J Cancer Res Clin Oncol 139:1523–1528 + + 10.1007/s00432-013-1471-8 + 23835897 + + + + Lo A, Li CP, Buza EL et al (2017) Fibroblast activation protein augments progression and metastasis of pancreatic ductal adenocarcinoma. JCI Insight 2:e92232 + + 10.1172/jci.insight.92232 + 28978805 + 5841864 + + + + Mao X, Xu J, Wang W et al (2021) Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives. Mol Cancer 20:131 + + 10.1186/s12943-021-01428-1 + 34635121 + 8504100 + + + + Altmann A, Haberkorn U, Siveke J (2021) The latest developments in imaging of fibroblast activation protein. J Nucl Med 62:160–167 + + 10.2967/jnumed.120.244806 + 33127618 + + + + Luo Y, Pan Q, Zhang W et al (2020) Intense FAPI uptake in inflammation may mask the tumor activity of pancreatic cancer in 68Ga-FAPI PET/CT. Clin Nucl Med 45:310–311 + + 10.1097/RLU.0000000000002914 + 31977474 + + + + Bulle A, Lim KH (2020) Beyond just a tight fortress: contribution of stroma to epithelial-mesenchymal transition in pancreatic cancer. Signal Transduct Target Ther 5:1–12 + + + Ogawa Y, Masugi Y (2021) Three distinct stroma types in human pancreatic cancer identified by image analysis of fibroblast subpopulations and collagen. Clin Cancer Res 27:107–119 + + 10.1158/1078-0432.CCR-20-2298 + 33046515 + + + + Saluja A, Maitra A (2019) Pancreatitis and pancreatic cancer. Gastroenterology 156:1937–1940 + + 10.1053/j.gastro.2019.03.050 + 30940522 + + + + +
+ + + 36809434 + + 2023 + 02 + 22 + +
+ + 1432-1084 + + + 2023 + Feb + 21 + + + European radiology + Eur Radiol + + Extensor carpi ulnaris tendon pathology and ulnar styloid bone marrow edema as diagnostic markers of peripheral triangular fibrocartilage complex tears on wrist MRI: a case-control study. + 10.1007/s00330-023-09446-x + + To evaluate extensor carpi ulnaris (ECU) tendon pathology and ulnar styloid process bone marrow edema (BME) as diagnostic MRI markers for peripheral triangular fibrocartilage complex (TFCC) tears. + One hundred thirty-three patients (age range 21-75, 68 females) with wrist 1.5-T MRI and arthroscopy were included in this retrospective case-control study. The presence of TFCC tears (no tear, central perforation, or peripheral tear), ECU pathology (tenosynovitis, tendinosis, tear or subluxation), and BME at the ulnar styloid process were determined on MRI and correlated with arthroscopy. Cross-tabulation with chi-square tests, binary logistic regression with odds ratios (OR), and sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were used to describe diagnostic efficacy. + On arthroscopy, 46 cases with no TFCC tear, 34 cases with central perforations, and 53 cases with peripheral TFCC tears were identified. ECU pathology was seen in 19.6% (9/46) of patients with no TFCC tears, in 11.8% (4/34) with central perforations and in 84.9% (45/53) with peripheral TFCC tears (p < 0.001); the respective numbers for BME were 21.7% (10/46), 23.5% (8/34), and 88.7% (47/53) (p < 0.001). Binary regression analysis showed additional value from ECU pathology and BME in predicting peripheral TFCC tears. The combined approach with direct MRI evaluation and both ECU pathology and BME yielded a 100% positive predictive value for peripheral TFCC tear as compared to 89% with direct evaluation alone. + ECU pathology and ulnar styloid BME are highly associated with peripheral TFCC tears and can be used as secondary signs to diagnose tears. + • ECU pathology and ulnar styloid BME are highly associated with peripheral TFCC tears and can be used as secondary signs to confirm the presence of TFCC tears. • If there is a peripheral TFCC tear on direct MRI evaluation and in addition both ECU pathology and BME on MRI, the positive predictive value is 100% that there will be a tear on arthroscopy compared to 89% with direct evaluation alone. • If there is no peripheral TFCC tear on direct evaluation and neither ECU pathology nor BME on MRI, the negative predictive value is 98% that there will be no tear on arthroscopy compared to 94% with direct evaluation alone. + © 2023. The Author(s). + + + + Nevalainen + Mika T + MT + http://orcid.org/0000-0002-9483-7690 + + Department of Diagnostic Radiology, Oulu University Hospital, P.O. Box 50, 90029, Oulu, Finland. mika.nevalainen@oulu.fi. + + + Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, POB 5000, FI-90014, Oulu, Finland. mika.nevalainen@oulu.fi. + + + Division of Musculoskeletal Imaging and Intervention, Department of Radiology, Thomas Jefferson University Hospitals, Sidney Kimmel Medical College at Thomas Jefferson University, 132 South 10th Street, Philadelphia, PA, 19107, USA. mika.nevalainen@oulu.fi. + + + + Zoga + Adam C + AC + + Division of Musculoskeletal Imaging and Intervention, Department of Radiology, Thomas Jefferson University Hospitals, Sidney Kimmel Medical College at Thomas Jefferson University, 132 South 10th Street, Philadelphia, PA, 19107, USA. + + + + Rivlin + Michael + M + + Department of Hand and Orthopaedic Surgery, Rothman Institute of Orthopaedics, Sidney Kimmel Medical College, Thomas Jefferson University, 925 Chestnut Street, 5th Floor, Philadelphia, PA, 19107, USA. + + + + Morrison + William B + WB + + Division of Musculoskeletal Imaging and Intervention, Department of Radiology, Thomas Jefferson University Hospitals, Sidney Kimmel Medical College at Thomas Jefferson University, 132 South 10th Street, Philadelphia, PA, 19107, USA. + + + + Roedl + Johannes B + JB + + Division of Musculoskeletal Imaging and Intervention, Department of Radiology, Thomas Jefferson University Hospitals, Sidney Kimmel Medical College at Thomas Jefferson University, 132 South 10th Street, Philadelphia, PA, 19107, USA. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Eur Radiol + 9114774 + 0938-7994 + + IM + + Bone marrow + Magnetic resonance imaging + Tears, tendons + Triangular fibrocartilage + Wrist + +
+ + + + 2022 + 08 + 13 + + + 2023 + 01 + 18 + + + 2022 + 12 + 30 + + + 2023 + 2 + 22 + 13 + 47 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809434 + 10.1007/s00330-023-09446-x + 10.1007/s00330-023-09446-x + + + + Daun M, Rudd A, Cheng K, Rezai F (2020) Magnetic resonance imaging of the triangular fibrocartilage complex. Top Magn Reson Imaging 29(5):237–244 + + 10.1097/RMR.0000000000000253 + 33021575 + + + + Palmer AK (1989) Triangular fibrocartilage complex lesions: a classification. J Hand Surg Am 14:594–606 + + 10.1016/0363-5023(89)90174-3 + 2666492 + + + + Nozaki T, Rafijah G, Yang L et al (2017) High-resolution 3 T MRI of traumatic and degenerative triangular fibrocartilage complex (TFCC) abnormalities using Palmer and Outerbridge classifications. Clin Radiol 72(10):904.e1-904.e10 + + 10.1016/j.crad.2017.04.011 + 28522258 + + + + Zhan H, Bai R, Qian Z, Yang Y, Zhang H, Yin Y (2020) Traumatic injury of the triangular fibrocartilage complex (TFCC)-a refinement to the Palmer classification by using high-resolution 3-T MRI. Skeletal Radiol 49(10):1567–1579 + + 10.1007/s00256-020-03438-4 + 32372253 + + + + Treiser MD, Crawford K, Iorio ML (2018) TFCC injuries: meta-analysis and comparison of diagnostic imaging modalities. J Wrist Surg 7(3):267–272 + + 10.1055/s-0038-1629911 + 29922507 + 6005773 + + + + Cherian BS, Bhat AK, Rajagopal KV, Maddukuri SB, Paul D, Mathai NJ (2019) Comparison of MRI & direct MR arthrography with arthroscopy in diagnosing ligament injuries of wrist. J Orthop 19:203–207 + + 10.1016/j.jor.2019.11.014 + 32071514 + 7010997 + + + + Daunt N, Couzens GB, Cutbush K, Green J, Ross M (2021) Accuracy of magnetic resonance imaging of the wrist for clinically important lesions of the major interosseous ligaments and triangular fibrocartilage complex; correlation with radiocarpal arthroscopy. Skeletal Radiol 50(8):1605–1616 + + 10.1007/s00256-020-03701-8 + 33474588 + + + + Skalski MR, White EA, Patel DB, Schein AJ, RiveraMelo H, Matcuk GR Jr (2016) The traumatized TFCC: an illustrated review of the anatomy and injury patterns of the triangular fibrocartilage complex. Curr Probl Diagn Radiol 45(1):39–50 + + 10.1067/j.cpradiol.2015.05.004 + 26117527 + + + + Atzei A, Luchetti R, Carletti D, Marcovici LL, Cazzoletti L, Barbon S (2021) The hook test is more accurate than the trampoline test to detect foveal tears of the triangular fibrocartilage complex of the wrist. Arthroscopy 37(6):1800–1807 + + 10.1016/j.arthro.2021.03.005 + 33745938 + + + + Mercaldo ND, Lau KF, Zhou XH (2007) Confidence intervals for predictive values with an emphasis to case-control studies. Stat Med 26:2170–2183 + + 10.1002/sim.2677 + 16927452 + + + + Haims AH, Schweitzer ME, Morrison WB et al (2002) Limitations of MR imaging in the diagnosis of peripheral tears of the triangular fibrocartilage of the wrist. AJR Am J Roentgenol 178(2):419–422 + + 10.2214/ajr.178.2.1780419 + 11804907 + + + + Magee T (2009) Comparison of 3-T MRI and arthroscopy of intrinsic wrist ligament and TFCC tears. AJR Am J Roentgenol 192(1):80–85 + + 10.2214/AJR.08.1089 + 19098183 + + + + Lee YH, Choi YR, Kim S, Song HT, Suh JS (2013) Intrinsic ligament and triangular fibrocartilage complex (TFCC) tears of the wrist: comparison of isovolumetric 3D-THRIVE sequence MR arthrography and conventional MR image at 3 T. Magn Reson Imaging 31(2):221–226 + + 10.1016/j.mri.2012.06.024 + 22959873 + + + + Santo S, Omokawa S, Iida A, Shimizu T, Hasegawa H, Tanaka Y (2018) Magnetic resonance imaging analysis of the extensor carpi ulnaris tendon and distal radioulnar joint in triangular fibrocartilage complex tears. J Orthop Sci 23(6):953–958 + + 10.1016/j.jos.2018.05.009 + 29983214 + + + + Verhiel S, Blackburn J, Ritt M, Simeone FJ, Chen NC (2020) MRI findings in patients undergoing triangular fibrocartilage complex repairs versus patients without ulnar-sided wrist pain. Hand (N Y) 19:1558944720937369 + + + Kim JN, Kwon ST, Shin HD (2021) Subluxation of the extensor carpi ulnaris on magnetic resonance imaging on neutral wrist position: correlation with tenosynovitis of the extensor carpi ulnaris and translation of the distal radioulnar joint. Skeletal Radiol 50(8):1593–1603 + + 10.1007/s00256-020-03705-4 + 33432435 + + + + +
+ + + 36809446 + + 2023 + 02 + 22 + +
+ + 1747-4892 + + 21 + 4 + + 2022 + + + Acute medicine + Acute Med + + Editorial - The NHS urgent and emergency care crisis: how much worse could it get? + + 166-167 + + 10.52964/AMJA.0919 + + NHS urgent and emergency care is under intolerable strain. This strain is increasingly causing harm to patients. Timely and high-quality patient care is often not being delivered due to overcrowding driven by workforce and capacity constraints. This drives low staff morale perpetuating burn out and high absence levels which currently dominate. Whilst COVID19 has accentuated and arguably expedited the crisis; the spiral of decline in urgent and emergency care has been decade long and unless urgent action is taken, we may not yet have reached its nadir. + + + + Cooksley + Tim + T + + Editor-in-Chief, Consultant in Acute Medicine, Manchester University Foundation Trust and The Christie. + + + + eng + + Journal Article + +
+ + England + Acute Med + 101553725 + 1747-4884 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 48 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809446 + 10.52964/AMJA.0919 + + +
+ + + 36809438 + + 2023 + 02 + 22 + +
+ + 1935-2735 + + 17 + 2 + + 2023 + Feb + 21 + + + PLoS neglected tropical diseases + PLoS Negl Trop Dis + + Challenges of implementation of the preventive chemotherapy neglected tropical diseases programme in Ghana. + + e0011116 + + 10.1371/journal.pntd.0011116 + + The Neglected Tropical Diseases programme since its implementation has improved the lives of many in the tropical and sub-tropical areas. Though witnessed many successes, the programme is continually facing challenges thus, preventing the attainment of various objectives. This study seeks to assess the challenges of implementation of the neglected tropical diseases programme in Ghana. + The thematic analysis approach was used to analyze qualitative data collected from 18 key public health managers selected through purposive and snowballing procedures from the national, regional and district levels of Ghana Health Service. Data collection was done through in-depth interviews using semi-structured interview guides in line with the objective of the study. + The Neglected Tropical Diseases Programme though received funding from external sources, faces multiple challenges which cut across financial, human and capital resources to external control. Specifically, inadequate resources, dwindling volunteerism, poor social mobilization, weak governmental commitment and weak monitoring were major challenges to implementation. These factors work individually and in combination to impede effective implementation. Ensuring state ownership, re-structuring implementation approaches to include top-down and bottom-up approaches and building capacity in monitoring and evaluation are recommended in order to meet the programme objectives and ensure sustainability. + This study forms part of an original study on Implementation of the NTDs programme in Ghana. Aside the key issues discussed, it presents first-hand information on major implementation challenges that are relevant to researchers, students, practitioners and the general public and will apply widely to vertically implemented programmes in Ghana. + Copyright: © 2023 Otoo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Otoo + Desmond Dzidzornu + DD + https://orcid.org/0000-0001-7507-9110 + + Department of Public Administration and Health Services Management, University of Ghana Business School, University of Ghana, Accra, Ghana. + + + + Agbenu + Ivy Akushika + IA + + Department Health Policy, Planning and Management, School of Public Health, University of Ghana, Accra, Ghana. + + + + Nyamekye + Mary Adebi + MA + + Department of Public Administration and Health Services Management, University of Ghana Business School, University of Ghana, Accra, Ghana. + + + + Appiah-Agyekum + Nana Nimo + NN + + Department of Public Administration and Health Services Management, University of Ghana Business School, University of Ghana, Accra, Ghana. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS Negl Trop Dis + 101291488 + 1935-2727 + + IM + The authors declare that there is no conflict of interest regarding the publication of this paper. +
+ + + + 2022 + 01 + 07 + + + 2023 + 01 + 20 + + + 2023 + 2 + 22 + 13 + 47 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809438 + 10.1371/journal.pntd.0011116 + PNTD-D-22-00035 + + +
+ + + 36809432 + + 2023 + 02 + 22 + +
+ + 1432-1084 + + + 2023 + Feb + 21 + + + European radiology + Eur Radiol + + Magnetic resonance spectroscopy and liquid chromatography-mass spectrometry metabolomics study may differentiate pre-eclampsia from gestational hypertension. + 10.1007/s00330-023-09454-x + + To investigate the findings of magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), and serum metabolomics for differentiating pre-eclampsia (PE) from gestational hypertension (GH). + This prospective study enrolled 176 subjects including a primary cohort with healthy non-pregnant women (HN, n = 35), healthy pregnant women (HP, n = 20), GH (n = 27), and PE (n = 39) and a validation cohort with HP (n = 22), GH (n = 22), and PE (n = 11). T1 signal intensity index (T1SI), apparent diffusion coefficient (ADC) value, and the metabolites on MRS were compared. The differentiating performances of single and combined MRI and MRS parameters for PE were evaluated. Serum liquid chromatography-mass spectrometry (LC-MS) metabolomics was investigated by sparse projection to latent structures discriminant analysis. + Increased T1SI, lactate/creatine (Lac/Cr), and glutamine and glutamate (Glx)/Cr and decreased ADC value and myo-inositol (mI)/Cr in basal ganglia were found in PE patients. T1SI, ADC, Lac/Cr, Glx/Cr, and mI/Cr yielded an area under the curves (AUC) of 0.90, 0.80, 0.94, 0.96, and 0.94 in the primary cohort, and of 0.87, 0.81, 0.91, 0.84, and 0.83 in the validation cohort, respectively. A combination of Lac/Cr, Glx/Cr, and mI/Cr yielded the highest AUC of 0.98 in the primary cohort and 0.97 in the validation cohort. Serum metabolomics analysis showed 12 differential metabolites, which are involved in pyruvate metabolism, alanine metabolism, glycolysis, gluconeogenesis, and glutamate metabolism. + MRS is expected to be a noninvasive and effective tool for monitoring GH patients to avoid the development of PE. + • Increased T1SI and decreased ADC value in the basal ganglia were found in PE patients than in GH patients. • Increased Lac/Cr and Glx/Cr, and decreased mI/Cr in the basal ganglia were found in PE patients than in GH patients. • LC-MS metabolomics showed that the major differential metabolic pathways between PE and GH were pyruvate metabolism, alanine metabolism, glycolysis, gluconeogenesis, and glutamate metabolism. + © 2023. The Author(s), under exclusive licence to European Society of Radiology. + + + + Liu + Xue-Fei + XF + + Department of Radiology, Jinshan Hospital, Fudan University, Shanghai, 201508, China. + + + + Li + Meng-Die + MD + + Department of Radiology, Jinshan Hospital, Fudan University, Shanghai, 201508, China. + + + + Lu + Jing-Jing + JJ + + Department of Radiology, Jinshan Hospital, Fudan University, Shanghai, 201508, China. + + + + Li + Ying + Y + http://orcid.org/0000-0001-5062-0230 + + Department of Radiology, Jinshan Hospital, Fudan University, Shanghai, 201508, China. dr.yingli@foxmail.com. + + + + Zeng + An-Rong + AR + + Department of Radiology, Jinshan Hospital, Fudan University, Shanghai, 201508, China. + + + + Qiang + Jin-Wei + JW + + Department of Radiology, Jinshan Hospital, Fudan University, Shanghai, 201508, China. dr.jinweiqiang@163.com. + + + + eng + + + ZK2019B01 + Shanghai Municipal Health Commission + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Eur Radiol + 9114774 + 0938-7994 + + IM + + Chromatography, liquid + Hypertension, pregnancy-induced + Magnetic resonance spectroscopy + Metabolomics + Pre-eclampsia + +
+ + + + 2022 + 04 + 27 + + + 2023 + 02 + 05 + + + 2023 + 01 + 12 + + + 2023 + 2 + 22 + 13 + 47 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809432 + 10.1007/s00330-023-09454-x + 10.1007/s00330-023-09454-x + + + + Tsakiridis I, Giouleka S, Arvanitaki A et al (2021) Gestational hypertension and preeclampsia: An overview of national and international guidelines. Obstet Gynecol Surv 76:613–633 + + 10.1097/OGX.0000000000000942 + 34724074 + + + + Haram K, Mortensen JH, Mastrolia SA, Erez O (2017) Disseminated intravascular coagulation in the HELLP syndrome: how much do we really know? J Matern Fetal Neonatal Med 30:779–788 + + 10.1080/14767058.2016.1189897 + 27181089 + + + + Auer J, Camoin L, Guillonneau F et al (2010) Serum profile in preeclampsia and intra-uterine growth restriction revealed by iTRAQ technology. J Proteomics 73:1004–1017 + + 10.1016/j.jprot.2009.12.014 + 20079470 + + + + Bozkurt M, Yumru AE, Sahin L, Salman S (2015) Troponin I and D-Dimer levels in preeclampsia and eclampsia: prospective study. Clin Exp Obstet Gynecol 42:26–31 + + 10.12891/ceog1949.2015 + 25864277 + + + + Salam RA, Das JK, Ali A, Bhaumik S, Lassi ZS (2015) Diagnosis and management of preeclampsia in community settings in low and middle-income countries. J Family Med Prim Care 4:501–506 + + 10.4103/2249-4863.174265 + 26985406 + 4776599 + + + + Pongrojpaw D, Chanthasenanont A, Nanthakomon T (2010) Second trimester uterine artery Doppler screening in prediction of adverse pregnancy outcome in high risk women. J Med Assoc Thai 7:127–130 + + + Hinchey J, Chaves C, Appignani B et al (1996) A reversible posterior leukoencephalopathy syndrome. N Engl J Med 334:494–500 + + 10.1056/NEJM199602223340803 + 8559202 + + + + Di X, Mai H, Zheng Z, Guo K, Morse AN, Liu H (2018) Neuroimaging findings in women who develop neurologic symptoms in severe preeclampsia with or without eclampsia. Hypertens Res 41:598–604 + + 10.1038/s41440-018-0051-3 + 29808032 + + + + Brewer J, Owens MY, Wallace K et al (2013) Posterior reversible encephalopathy syndrome in 46 of 47 patients with eclampsia. Am J Obstet Gynecol 208:468.e1-e6 + + 10.1016/j.ajog.2013.02.015 + 23395926 + + + + Nelander M, Hannsberger D, Sundström-Poromaa I et al (2018) Assessment of cerebral perfusion and edema in preeclampsia with intravoxel incoherent motion MRI. Acta Obstet Gynecol Scand 97:1212–1218 + + 10.1111/aogs.13383 + 29786833 + + + + Nicholson JK, Lindon JC, Holmes E (1999) ‘Metabonomics’: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 29:1181–1189 + + 10.1080/004982599238047 + 10598751 + + + + Nelander M, Wikström AK, Weis J et al (2018) Cerebral osmolytes and plasma osmolality in pregnancy and preeclampsia: a proton magnetic resonance spectroscopy study. Am J Hypertens 31:847–853 + + 10.1093/ajh/hpy019 + 29415199 + + + + Rutherford JM, Moody A (2003) Crawshaw S, Magnetic resonance spectroscopy in pre-eclampsia: evidence of cerebral ischaemia. BJOG 110:416–423 + + 10.1046/j.1471-0528.2003.00416.x + 12699805 + + + + Turner E, Brewster JA, Simpson NAB, Walker JJ, Fisher J (2007) Plasma from women with preeclampsia has a low lipid and ketone body content–a nuclear magnetic resonance study. Hypertens Pregnancy 26:329–342 + + 10.1080/10641950701436073 + 17710581 + + + + Odibo AO, Goetzinger KR, Odibo L et al (2011) First-trimester prediction of preeclampsia using metabolomic biomarkers: a discovery phase study. Prenat Diagn 31:990–994 + + 10.1002/pd.2822 + 21744367 + 3713070 + + + + Rohart F, Gautier B, Singh A, LeCao KA (2017) mixOmics: an R package for ‘omics feature selection and multiple data integration. PLoS Comput Biol 13:e1005752 + + 10.1371/journal.pcbi.1005752 + 29099853 + 5687754 + + + + Casey SO, Sampaio RC, Michel E, Truwit CL (2000) Posterior reversible encephalopathy syndrome: utility of fluid-attenuated inversion recovery MR imaging in the detection of cortical and subcortical lesions. AJNR Am J Neuroradiol 21:1199–1206 + + 10954269 + 8174901 + + + + Postma IR, Slager S, Kremer HP, De Groot JC, Zeeman GG (2014) Long-term consequences of the posterior reversible encephalopathy syndrome in eclampsia and preeclampsia: a review of the obstetric and nonobstetric literature. Obstet Gynecol Surv 69:287–300 + + 10.1097/OGX.0000000000000069 + 25101694 + + + + Demirtas O, Gelal F, Vidinli BD, Demirtas LO, Uluc E, Baloğlu A (2005) Cranial MR imaging with clinical correlation in preeclampsia and eclampsia. Diagn Interv Radiol 11:189–194 + + 16320222 + + + + Li SJ, Jiang L, Fu X et al (2014) Pallidal index as biomarker of manganese brain accumulation and associated with manganese levels in blood: a meta-analysis. PLoS One 9:e93900 + + 10.1371/journal.pone.0093900 + 24718592 + 3981755 + + + + Sarwar MS, Ahmed S, Ullah MS et al (2013) Comparative study of serum zinc, copper, manganese, and iron in preeclamptic pregnant women. Biol Trace Elem Res 154:14–20 + + 10.1007/s12011-013-9721-9 + 23749478 + + + + Vigeh M, Yokoyama K, Ramezanzadeh F et al (2006) Lead and other trace metals in preeclampsia: a case-control study in Tehran. Iran Environ Res 100:268–275 + + 10.1016/j.envres.2005.05.005 + 16029873 + + + + Fitsanakis VA, Zhang N, Avison MJ, Erikson KM, Gore JC, Aschner M (2011) Changes in dietary iron exacerbate regional brain manganese accumulation as determined by magnetic resonance imaging. Toxicol Sci 120:146–153 + + 10.1093/toxsci/kfq376 + 21177776 + + + + Li Y, Mei L, Qiang J, Ju S, Zhao S (2016) Magnetic resonance spectroscopy for evaluating portal-systemic encephalopathy in patients with chronic hepatic schistosomiasis Japonicum. PLoS Negl Trop Dis 10:e0005232 + + 10.1371/journal.pntd.0005232 + 27977668 + 5199111 + + + + Li Y, Qiang JW, Ju S (2013) Brain MR imaging changes in patients with hepatic schistosomiasis japonicum without liver dysfunction. Neurotoxicology 35:101–105 + + 10.1016/j.neuro.2012.12.008 + 23298871 + + + + Nelander M, Weis J, Bergman L, Larsson A, Wikström AK, Wikström J (2017) Cerebral magnesium levels in preeclampsia; a phosphorus magnetic resonance spectroscopy study. Am J Hypertens 30:667–672 + + 10.1093/ajh/hpx022 + 28338765 + + + + Euser AG, Cipolla MJ (2009) Magnesium sulfate for the treatment of eclampsia: a brief review. Stroke 40:1169–1175 + + 10.1161/STROKEAHA.108.527788 + 19211496 + 2663594 + + + + McKinney AM, Filice RW, Teksam M et al (2004) Diffusion abnormalities of the globi pallidi in manganese neurotoxicity. Neuroradiology 46:291–295 + + 10.1007/s00234-004-1179-1 + 15045494 + + + + Distefano G, Praticò AD (2010) Actualities on molecular pathogenesis and repairing processes of cerebral damage in perinatal hypoxic-ischemic encephalopathy. Ital J Pediatr 36:63 + + 10.1186/1824-7288-36-63 + 20846380 + 2954868 + + + + Zwingmann C, Leibfritz D, Hazell AS (2003) Energy metabolism in astrocytes and neurons treated with manganese: relation among cell-specific energy failure, glucose metabolism, and intercellular trafficking using multinuclear NMR-spectroscopic analysis. J Cereb Blood Flow Metab 23:756–771 + + 10.1097/01.WCB.0000056062.25434.4D + 12796724 + + + + Flo K, Blix ES, Husebekk A et al (2016) A longitudinal study of maternal endothelial function, inflammatory response and uterine artery blood flow during the second half of pregnancy. Acta Obstet Gynecol Scand 95:225–232 + + 10.1111/aogs.12802 + 26462064 + + + + Ewertsen C, Kondziella D, Danielsen ER, Thomsen C (2015) Good outcome after posterior reversible encephalopathy syndrome (PRES) despite elevated cerebral lactate: a case report. Acta Radiol Open 4:2058460115578324 + + 26331088 + 4548744 + + + + Takado Y, Sato N, Kanbe Y et al (2019) Association between brain and plasma glutamine levels in healthy young subjects investigated by MRS and LC/MS. Nutrients. https://doi.org/10.3390/nu11071649 + + 10.3390/nu11071649 + 31330962 + 6682979 + + + + Andersen JV, Nissen JD, Christensen SK, Markussen KH, Waagepetersen HS (2017) Impaired hippocampal glutamate and glutamine metabolism in the db/db mouse model of type 2 diabetes mellitus. Neural Plast 2017:2107084 + + 10.1155/2017/2107084 + 28695014 + 5488168 + + + + Albrecht J, Norenberg MD (2006) Glutamine: a Trojan horse in ammonia neurotoxicity. Hepatology 44:788–794 + + 10.1002/hep.21357 + 17006913 + + + + Rutherford JM, Moody A, Crawshaw S, Rubin PC (2003) Magnetic resonance spectroscopy in pre-eclampsia: evidence of cerebral ischaemia. BJOG 110:416–423 + + 10.1046/j.1471-0528.2003.00416.x + 12699805 + + + + Miller BL, Chang L, Booth R et al (1996) In vivo 1H MRS choline: correlation with in vitro chemistry/histology. 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+ + + 36809448 + + 2023 + 02 + 22 + +
+ + 1747-4892 + + 21 + 4 + + 2022 + + + Acute medicine + Acute Med + + Blood Culture and Troponin Testing in Suspected Bacteraemic Admissions - Example of Risk Stratification Based on Clinical Testing. + + 176-181 + + 10.52964/AMJA.0921 + + To investigate the clinical predictive value of troponin (hscTnT) and blood culture testing. + We examined all medical admissions from 2011-2020. Prediction of 30-day in-hospital mortality, dependent on blood culture and hscTnT requests/results, was evaluated using multiple variable logistic regression. Length of stay was related to utilization of procedures/services with truncated Poisson regression. + There were 77,566 admissions in 42,325 patients. With both blood cultures and hscTnT requested, 30-day in-hospital mortality increased to 20.9% (95%CI: 19.7, 22.1) vs 8.9% (95%CI: 8.5, 9.4) for blood cultures alone and 2.3% (95%CI: 2.2, 2.4) with neither. Blood culture 3.93 (95%CI: 3.50, 4.42) or hsTnT requests 4.58 (95%CI: 4.10, 5.14) were prognostic. + Blood culture and hscTnT requests and results predict worse outcomes. + + + + Conway + R + R + + MD, Department of Internal Medicine, St James's Hospital, Dublin 8, Ireland. + + + + Byrne + D + D + + MD, PhD, Department of Internal Medicine, St James's Hospital, Dublin 8, Ireland. + + + + O'Riordan + D + D + + MD, Department of Internal Medicine, St James's Hospital, Dublin 8, Ireland. + + + + Silke + B + B + + MD DSc, Department of Internal Medicine, St James's Hospital, Dublin 8, Ireland. + + + + eng + + Journal Article + +
+ + England + Acute Med + 101553725 + 1747-4884 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 48 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809448 + 10.52964/AMJA.0921 + + +
+ + + 36809433 + + 2023 + 02 + 22 + +
+ + 1432-1084 + + + 2023 + Feb + 21 + + + European radiology + Eur Radiol + + Optimization of null point in Look-Locker images for myocardial late gadolinium enhancement imaging using deep learning and a smartphone. + 10.1007/s00330-023-09465-8 + + To determine the optimal inversion time (TI) from Look-Locker scout images using a convolutional neural network (CNN) and to investigate the feasibility of correcting TI using a smartphone. + In this retrospective study, TI-scout images were extracted using a Look-Locker approach from 1113 consecutive cardiac MR examinations performed between 2017 and 2020 with myocardial late gadolinium enhancement. Reference TI null points were independently determined visually by an experienced radiologist and an experienced cardiologist, and quantitatively measured. A CNN was developed to evaluate deviation of TI from the null point and then implemented in PC and smartphone applications. Images on 4 K or 3-megapixel monitors were captured by a smartphone, and CNN performance on each monitor was determined. Optimal, undercorrection, and overcorrection rates using deep learning on the PC and smartphone were calculated. For patient analysis, TI category differences in pre- and post-correction were evaluated using the TI null point used in late gadolinium enhancement imaging. + For PC, 96.4% (772/749) of images were classified as optimal, with under- and overcorrection rates of 1.2% (9/749) and 2.4% (18/749), respectively. For 4 K images, 93.5% (700/749) of images were classified as optimal, with under- and overcorrection rates of 3.9% (29/749) and 2.7% (20/749), respectively. For 3-megapixel images, 89.6% (671/749) of images were classified as optimal, with under- and overcorrection rates of 3.3% (25/749) and 7.0% (53/749), respectively. On patient-based evaluations, subjects classified as within optimal range increased from 72.0% (77/107) to 91.6% (98/107) using the CNN. + Optimizing TI on Look-Locker images was feasible using deep learning and a smartphone. + • A deep learning model corrected TI-scout images to within optimal null point for LGE imaging. • By capturing the TI-scout image on the monitor with a smartphone, the deviation of the TI from the null point can be immediately determined. • Using this model, TI null points can be set to the same degree as that by an experienced radiological technologist. + © 2023. The Author(s), under exclusive licence to European Society of Radiology. + + + + Ohta + Yasutoshi + Y + http://orcid.org/0000-0001-8286-0271 + + Department of Radiology, National Cerebral and Cardiovascular Center, Suita City, Osaka, 564-8565, Japan. ohtayasu@gmail.com. + + + + Tateishi + Emi + E + + Department of Radiology, National Cerebral and Cardiovascular Center, Suita City, Osaka, 564-8565, Japan. + + + + Morita + Yoshiaki + Y + + Department of Radiology, National Cerebral and Cardiovascular Center, Suita City, Osaka, 564-8565, Japan. + + + + Nishii + Tatsuya + T + + Department of Radiology, National Cerebral and Cardiovascular Center, Suita City, Osaka, 564-8565, Japan. + + + + Kotoku + Akiyuki + A + + Department of Radiology, National Cerebral and Cardiovascular Center, Suita City, Osaka, 564-8565, Japan. + + + + Horinouchi + Hiroki + H + + Department of Radiology, National Cerebral and Cardiovascular Center, Suita City, Osaka, 564-8565, Japan. + + + + Fukuyama + Midori + M + + Department of Radiology, National Cerebral and Cardiovascular Center, Suita City, Osaka, 564-8565, Japan. + + + + Fukuda + Tetsuya + T + + Department of Radiology, National Cerebral and Cardiovascular Center, Suita City, Osaka, 564-8565, Japan. + + + + eng + + + 19K17188 + Japan Society for the Promotion of Science + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Eur Radiol + 9114774 + 0938-7994 + + IM + + Deep learning + Gadolinium + Heart + Magnetic resonance imaging + Smartphone + +
+ + + + 2022 + 09 + 27 + + + 2023 + 01 + 22 + + + 2022 + 09 + 27 + + + 2023 + 2 + 22 + 13 + 47 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809433 + 10.1007/s00330-023-09465-8 + 10.1007/s00330-023-09465-8 + + + + Mahrholdt H, Wagner A, Judd RM et al (2005) Delayed enhancement cardiovascular magnetic resonance assessment of non-ischaemic cardiomyopathies. Eur Heart J 26:1461–1474. https://doi.org/10.1093/eurheartj/ehi258 + + 10.1093/eurheartj/ehi258 + 15831557 + + + + Gräni C, Eichhorn C, Bière L et al (2019) Comparison of myocardial fibrosis quantification methods by cardiovascular magnetic resonance imaging for risk stratification of patients with suspected myocarditis. J Cardiovasc Magn Reson 21:14. https://doi.org/10.1186/s12968-019-0520-0 + + 10.1186/s12968-019-0520-0 + 30813942 + 6393997 + + + + Schelbert EB, Cao JJ, Sigurdsson S et al (2012) Prevalence and prognosis of unrecognized myocardial infarction determined by cardiac magnetic resonance in older adults. JAMA 308:890–896. https://doi.org/10.1001/2012.jama.11089 + + 10.1001/2012.jama.11089 + 22948699 + 4137910 + + + + Look DC, Locker DR (1970) Time saving in measurement of NMR and EPR relaxation times. Rev Sci Instrum 41:250–251. https://doi.org/10.1063/1.1684482 + + 10.1063/1.1684482 + + + + Kim RJ, Shah DJ, Judd RM (2003) How we perform delayed enhancement imaging: HOW I DO…. J Cardiovasc Magn Reson 5:505–514 + + 10.1081/JCMR-120022267 + 12882082 + + + + Krizhevsky A, Sutskever I, Hinton GE (2017) ImageNet classification with deep convolutional neural networks. Commun ACM 60:84–90. https://doi.org/10.1145/3065386 + + 10.1145/3065386 + + + + Szegedy C, Liu W, Jia YQ et al (2015) Going deeper with convolutions. Ieee Conference on Computer Vision and Pattern Recognition (Cvpr) 2015:1–9 + + + He KM, Zhang XY, Ren SQ, et al (2016) Deep residual learning for image recognition. In: 2016 IEEE Conference on Computer Vision and Pattern Recognition. pp 770–778 + + + Bejnordi BE, Veta M, van Diest PJ et al (2017) Diagnostic assessment of deep learning algorithms for detection of lymph node metastases in women with breast cancer. JAMA 318:2199–2210. https://doi.org/10.1001/jama.2017.14585 + + + Lakhani P, Sundaram B (2017) Deep learning at chest radiography: automated classification of pulmonary tuberculosis by using convolutional neural networks. Radiology 284:574–582. https://doi.org/10.1148/radiol.2017162326 + + 10.1148/radiol.2017162326 + 28436741 + + + + Ohta Y, Yunaga H, Kitao S, et al (2019) Detection and classification of myocardial delayed enhancement patterns on MR images with deep neural networks: A feasibility study. Radiol Artif Intell 1:e180061. https://doi.org/10.1148/ryai.2019180061 + + + Fenner BJ, Wong RLM, Lam W-C et al (2018) Advances in retinal imaging and applications in diabetic retinopathy screening: a review. Ophthalmol Ther 7:333–346. https://doi.org/10.1007/s40123-018-0153-7 + + 10.1007/s40123-018-0153-7 + 30415454 + 6258577 + + + + Poostchi M, Silamut K, Maude RJ et al (2018) Image analysis and machine learning for detecting malaria. Transl Res 194:36–55. https://doi.org/10.1016/j.trsl.2017.12.004 + + 10.1016/j.trsl.2017.12.004 + 29360430 + 5840030 + + + + Banik S, Melanthota SK, Arbaaz, et al (2021) Recent trends in smartphone-based detection for biomedical applications: a review. Anal Bioanal Chem 413:2389–2406. https://doi.org/10.1007/s00216-021-03184-z + + + Lim G, Bellemo V, Xie Y, Lee XQ, Yip MYT, Ting DSW (2020) Different fundus imaging modalities and technical factors in AI screening for diabetic retinopathy: a review. Eye Vis (Lond) 7:21. https://doi.org/10.1186/s40662-020-00182-7 + + 10.1186/s40662-020-00182-7 + 32313813 + + + + Simonyan K, Zisserman A (2014) Very deep convolutional networks for large-scale image recognition. arXiv [cs.CV] + + + Wu R, Yan S, Shan Y, et al (2015) Deep image: scaling up image recognition. arXiv [cs.CV] + + + Tan M, Le QV (2019) EfficientNet: rethinking model scaling for convolutional neural networks. arXiv [cs.LG] + + + Kanda Y (2013) Investigation of the freely available easy-to-use software “EZR” for medical statistics. Bone Marrow Transplant 48:452–458. https://doi.org/10.1038/bmt.2012.244 + + 10.1038/bmt.2012.244 + 23208313 + + + + Kramer CM, Barkhausen J, Bucciarelli-Ducci C et al (2020) Standardized cardiovascular magnetic resonance imaging (CMR) protocols: 2020 update. J Cardiovasc Magn Reson 22:17. https://doi.org/10.1186/s12968-020-00607-1 + + 10.1186/s12968-020-00607-1 + 32089132 + 7038611 + + + + Varga-Szemes A, van der Geest RJ, Spottiswoode BS et al (2016) Myocardial late gadolinium enhancement: accuracy of T1 mapping–based synthetic inversion-recovery imaging. Radiology 278:374–382. https://doi.org/10.1148/radiol.2015150162 + + 10.1148/radiol.2015150162 + 26230908 + + + + +
+ + + 36809442 + + 2023 + 02 + 22 + +
+ + 1432-198X + + + 2023 + Feb + 21 + + + Pediatric nephrology (Berlin, Germany) + Pediatr Nephrol + + Ascertaining pathogenicity of genetic variants: caution required. + 10.1007/s00467-023-05909-x + + + Arslan + Zainab + Z + http://orcid.org/0000-0002-1126-3995 + + Department of Paediatric Nephrology, Great Ormond Street Hospital for Children, London, UK. Zainab.arslan@gosh.nhs.uk. + + + + Watson + Elizabeth + E + + Southwest Genomic Laboratory Hub, Bristol Genetics Laboratory, Southmead Hospital, Bristol, UK. + + + + Bockenhauer + Detlef + D + http://orcid.org/0000-0001-5878-941X + + Department of Paediatric Nephrology, Great Ormond Street Hospital for Children, London, UK. + + + Department of Renal Medicine, University College London, London, UK. + + + + eng + + Letter + + + 2023 + 02 + 21 + +
+ + Germany + Pediatr Nephrol + 8708728 + 0931-041X + + IM +
+ + + + 2023 + 02 + 09 + + + 2023 + 02 + 10 + + + 2023 + 02 + 09 + + + 2023 + 2 + 22 + 13 + 47 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809442 + 10.1007/s00467-023-05909-x + 10.1007/s00467-023-05909-x + + + + Fujinaga S, Sakuraya K (2023) High prevalence of pathogenic variants in Japanese children with steroid-resistant nephrotic syndrome without edema detected by urine screening program. Pediatr Nephrol. https://doi.org/10.1007/s00467-022-05863-0 + + + Arslan Z, Webb H, Ashton E, Foxler B, Tullus K, Waters A, Bockenhauer D (2022) Mendelian steroid resistant nephrotic syndrome in childhood: is it as common as reported? Pediatr Nephrol: https://doi.org/10.1007/s00467-022-05569-3 + + + Gale DP, Mallett A, Patel C, Sneddon TP, Rehm HL, Sampson MG, Bockenhauer D (2020) Diagnoses of uncertain significance: kidney genetics in the 21st century. Nat Rev Nephrol 16:616–618. https://doi.org/10.1038/s41581-020-0277-6 + + 10.1038/s41581-020-0277-6 + 32265521 + + + + Winn MP, Conlon PJ, Lynn KL, Farrington MK, Creazzo T, Hawkins AF, Daskalakis N, Kwan SY, Ebersviller S, Burchette JL, Pericak-Vance MA, Howell DN, Vance JM, Rosenberg PB (2005) A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis. Science 308:1801–1804. https://doi.org/10.1126/science.1106215 + + 10.1126/science.1106215 + 15879175 + + + + Odenthal J, Dittrich S, Ludwig V, Merz T, Reitmeier K, Reusch B, Hoehne M, Cosgun ZC, Hohenadel M, Putnik J, Goebel H, Rinschen MM, Altmuller J, Koehler S, Schermer B, Benzing T, Beck BB, Brinkkoetter PT, Habbig S, Bartram MP (2022) Modeling of ACTN4-based podocytopathy using drosophila nephrocytes. Kidney Int Rep. https://doi.org/10.1016/j.ekir.2022.10.024 + + + +
+ + + 36809439 + + 2023 + 02 + 22 + +
+ + 1932-6203 + + 18 + 2 + + 2023 + + + PloS one + PLoS One + + Multivariate GWAS analysis reveals loci associated with liver functions in continental African populations. + + e0280344 + + 10.1371/journal.pone.0280344 + + Liver disease is any condition that causes liver damage and inflammation and may likely affect the function of the liver. Vital biochemical screening tools that can be used to evaluate the health of the liver and help diagnose, prevent, monitor, and control the development of liver disease are known as liver function tests (LFT). LFTs are performed to estimate the level of liver biomarkers in the blood. Several factors are associated with differences in concentration levels of LFTs in individuals, such as genetic and environmental factors. The aim of our study was to identify genetic loci associated with liver biomarker levels with a shared genetic basis in continental Africans, using a multivariate genome-wide association study (GWAS) approach. + We used two distinct African populations, the Ugandan Genome Resource (UGR = 6,407) and South African Zulu cohort (SZC = 2,598). The six LFTs used in our analysis were: aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), total bilirubin, and albumin. A multivariate GWAS of LFTs was conducted using the exact linear mixed model (mvLMM) approach implemented in GEMMA and the resulting P-values were presented in Manhattan and quantile-quantile (QQ) plots. First, we attempted to replicate the findings of the UGR cohort in SZC. Secondly, given that the genetic architecture of UGR is different from that of SZC, we further undertook similar analysis in the SZC and discussed the results separately. + A total of 59 SNPs reached genome-wide significance (P = 5x10-8) in the UGR cohort and with 13 SNPs successfully replicated in SZC. These included a novel lead SNP near the RHPN1 locus (lead SNP rs374279268, P-value = 4.79x10-9, Effect Allele Frequency (EAF) = 0.989) and a lead SNP at the RGS11 locus (lead SNP rs148110594, P-value = 2.34x10-8, EAF = 0.928). 17 SNPs were significant in the SZC, while all the SNPs fall within a signal on chromosome 2, rs1976391 mapped to UGT1A was identified as the lead SNP within this region. + Using multivariate GWAS method improves the power to detect novel genotype-phenotype associations for liver functions not found with the standard univariate GWAS in the same dataset. + Copyright: © 2023 Soremekun et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Soremekun + Chisom + C + + The African Computational Genomics (TACG) Research Group, MRC/UVRI, and LSHTM, Entebbe, Uganda. + + + Department of Immunology and Molecular Biology, College of Health Science, Makerere University, Kampala, Uganda. + + + H3Africa Bioinformatics Network (H3ABioNet) Node, Centre for Genomics Research and Innovation, NABDA/FMST, Abuja, Nigeria. + + + + Machipisa + Tafadzwa + T + + Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa. + + + Department of Medicine, Hatter Institute for Cardiovascular Diseases Research in Africa and Cape Heart Institute, University of Cape Town, Cape Town, South Africa. + + + Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada. + + + Thrombosis and Atherosclerosis Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada. + + + Department of Pathology and Molecular Medicine, McMaster University, Michael G. DeGroote School of Medicine, Hamilton, Ontario, Canada. + + + + Soremekun + Opeyemi + O + + The African Computational Genomics (TACG) Research Group, MRC/UVRI, and LSHTM, Entebbe, Uganda. + + + Molecular Bio-Computation and Drug Design Laboratory, School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban, South Africa. + + + + Pirie + Fraser + F + + Department of Diabetes and Endocrinology, University of KwaZulu-Natal, Durban, South Africa. + + + + Oyekanmi + Nashiru + N + https://orcid.org/0000-0002-0796-7834 + + H3Africa Bioinformatics Network (H3ABioNet) Node, Centre for Genomics Research and Innovation, NABDA/FMST, Abuja, Nigeria. + + + + Motala + Ayesha A + AA + + Department of Diabetes and Endocrinology, University of KwaZulu-Natal, Durban, South Africa. + + + + Chikowore + Tinashe + T + + Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. + + + Department of Pediatrics, MRC/Wits Developmental Pathways for Health Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. + + + + Fatumo + Segun + S + https://orcid.org/0000-0003-4525-3362 + + The African Computational Genomics (TACG) Research Group, MRC/UVRI, and LSHTM, Entebbe, Uganda. + + + H3Africa Bioinformatics Network (H3ABioNet) Node, Centre for Genomics Research and Innovation, NABDA/FMST, Abuja, Nigeria. + + + Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors declare that they have no competing interests. +
+ + + + 2022 + 07 + 27 + + + 2022 + 12 + 27 + + + 2023 + 2 + 22 + 13 + 47 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809439 + 10.1371/journal.pone.0280344 + PONE-D-22-20300 + + +
+ + + 36809436 + + 2023 + 02 + 22 + +
+ + 1610-7365 + + + 2023 + Feb + 21 + + + Primates; journal of primatology + Primates + + Macaque progressions: passing order during single-file movements reflects the social structure of a wild stump-tailed macaque group. + 10.1007/s10329-023-01055-y + + Inferring the latent structures of social organisations is a central theme in animal ecology. Sophisticated theoretical frameworks underpin the study of various primate social systems. Single-file movements, defined as serially ordered patterns of animals, reflect intra-group social relationships and provide a key to understanding social structures. Here, we analysed automated camera-trapping data on the order of progression of single-file movements in a free-ranging group of stump-tailed macaques to estimate the social structure of the group. The sequence of single file movements showed some regularities, particularly for adult males. Social network analysis identified four community clusters (subgroups) corresponding to the social structures reported for these stumptailed macaques, i.e. males that had copulated more frequently with females were spatially clustered with females, but males that had copulated less frequently were spatially isolated from females. Our results suggest that stumptailed macaques move in regular, socially determined patterns that reflect the spatial positions of adult males and are related to the social organisation of the species. + © 2023. The Author(s), under exclusive licence to Japan Monkey Centre. + + + + Toyoda + Aru + A + http://orcid.org/0000-0003-1784-8553 + + Chubu University Academy of Emerging Sciences, Kasugai, Aichi, 487-8501, Japan. aru.toyoda@gmail.com. + + + National Primate Research Center of Thailand, Chulalongkorn University, Saraburi, 18110, Thailand. aru.toyoda@gmail.com. + + + + Maruhashi + Tamaki + T + + Musashi University, Nerima, Tokyo, 176-8534, Japan. + + + + Malaivijitnond + Suchinda + S + + National Primate Research Center of Thailand, Chulalongkorn University, Saraburi, 18110, Thailand. + + + Department of Biology, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand. + + + + Matsudaira + Kazunari + K + + Graduate School of Asian and African Area Studies, Kyoto University, Yoshida Honmachi, Sakyo-ku, Kyoto, 606-8510, Japan. + + + + Arai + Zin + Z + + Chubu University Academy of Emerging Sciences, Kasugai, Aichi, 487-8501, Japan. + + + + Matsuda + Ikki + I + + Chubu University Academy of Emerging Sciences, Kasugai, Aichi, 487-8501, Japan. + + + Wildlife Research Center of Kyoto University, 2-24 Tanaka-Sekiden-Cho, Sakyo, Kyoto, 606-8203, Japan. + + + Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah, Jalan UMS, 88400, Kota Kinabalu, Sabah, Malaysia. + + + Chubu Institute for Advanced Studies, Chubu University, Kasugai, Aichi, 487-8501, Japan. + + + + Koda + Hiroki + H + http://orcid.org/0000-0002-0927-3473 + + Graduate School of Arts and Sciences, The University of Tokyo, Komaba, Tokyo, 153-8902, Japan. hkoda@g.ecc.u-tokyo.ac.jp. + + + + eng + + + #16J0098 + Japan Society for the Promotion of Science + + + + #19KK0191 + Japan Society for the Promotion of Science + + + + #22K13802 + Japan Society for the Promotion of Science + + + + 17941861 + Core Research for Evolutional Science and Technology + + + + 17H06380 + Ministry of Education, Culture, Sports, Science and Technology + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Japan + Primates + 0401152 + 0032-8332 + + IM + + Camera-trapping + Community estimation + Macaque society + Single-file movements + Social network analysis + +
+ + + + 2022 + 05 + 11 + + + 2023 + 01 + 29 + + + 2023 + 2 + 22 + 13 + 47 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809436 + 10.1007/s10329-023-01055-y + 10.1007/s10329-023-01055-y + + + + Altmann J (1974) Observational study of behavior: sampling methods. Behaviour 49:227–267. https://doi.org/10.1163/156853974x00534 + + 10.1163/156853974x00534 + 4597405 + + + + Altmann SA (1979) Baboon progressions: order or chaos? A study of one-dimensional group geometry. Anim Behav 27:46–80. https://doi.org/10.1016/0003-3472(79)90128-3 + + 10.1016/0003-3472(79)90128-3 + + + + Aureli F, Schaffner CM, Verpooten J, Slater K, Ramos-Fernandez G (2006) Raiding parties of male spider monkeys: insights into human warfare? Am J Phys Anthropol 131:486–497. https://doi.org/10.1002/ajpa.20451 + + 10.1002/ajpa.20451 + 16685723 + + + + Barelli C, Reichard U, Boesch C, Heistermann M (2008) Female white-handed gibbons (Hylobates lar) lead group movements and have priority of access to food resources. Behaviour 145:965–981. https://doi.org/10.1163/156853908784089243 + + 10.1163/156853908784089243 + + + + Bernstein IS (1976) Dominance, aggression and reproduction in primate societies. J Theor Biol 60:459–472. https://doi.org/10.1016/0022-5193(76)90072-2 + + 10.1016/0022-5193(76)90072-2 + 822241 + + + + Butovskaya M (1993) Kinship and different dominance styles in groups of three species of the genus Macaca (M. arctoides, M. mulatta, M. fascicularis). Folia Primatol (Basel) 60:210–224. https://doi.org/10.1159/000156694 + + 10.1159/000156694 + 8300016 + + + + Caine N, Mitchell G (1979) A review of play in the genus Macaca: social correlates. Primates 20:535–546. https://doi.org/10.1007/bf02373435 + + 10.1007/bf02373435 + + + + Clutton-Brock T (2016) Mammal societies. Wiley + + + de Waal FBM, Luttrell LM (1989) Toward a comparative socioecology of the genus Macaca: different dominance styles in rhesus and stumptail monkeys. Am J Primatol 19:83–109. https://doi.org/10.1002/ajp.1350190203 + + 10.1002/ajp.1350190203 + 31964014 + + + + de Waal FBM, Ren R (1988) Comparison of the reconciliation behavior of stumptail and rhesus macaques. Ethology 78:129–142. https://doi.org/10.1111/j.1439-0310.1988.tb00224.x + + 10.1111/j.1439-0310.1988.tb00224.x + + + + Dore KM et al (2020) Review of GPS collar deployments and performance on nonhuman primates. Primates. https://doi.org/10.1007/s10329-020-00793-7 + + 10.1007/s10329-020-00793-7 + 32026151 + 8118416 + + + + Erhart EM, Overdorff DJ (1999) Female coordination of group travel in wild Propithecus and Eulemur. Int J Primatol 20:927–940. https://doi.org/10.1023/a:1020830703012 + + 10.1023/a:1020830703012 + + + + Estep DQ, Nieuwenhuijsen K, Bruce KEM, De Neef KJ, Walters PA, Baker SC, Koos Slob A (1988) Inhibition of sexual behaviour among subordinate stumptail macaques, Macaca arctoides. Anim Behav 36:854–864. https://doi.org/10.1016/s0003-3472(88)80168-4 + + 10.1016/s0003-3472(88)80168-4 + + + + Fischhoff IR, Sundaresan SR, Cordingley J, Larkin HM, Sellier M-J, Rubenstein DI (2007) Social relationships and reproductive state influence leadership roles in movements of plains zebra, Equus burchellii. Anim Behav 73:825–831. https://doi.org/10.1016/j.anbehav.2006.10.012 + + 10.1016/j.anbehav.2006.10.012 + + + + Furuichi T (1989) Social interactions and the life history of female Pan paniscus in Wamba, Zaire. Int J Primatol 10:173–197. https://doi.org/10.1007/bf02735199 + + 10.1007/bf02735199 + + + + Gouzoules H (1974) Harassment of sexual behavior in the stumptail macaque, Macaca arctoides. 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+ + + 36809437 + + 2023 + 02 + 22 + +
+ + 1573-2649 + + + 2023 + Feb + 21 + + + Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation + Qual Life Res + + Examining the psychometric properties of a split version of the EQ-5D-5L anxiety/depression dimension in patients with anxiety and/or depression. + 10.1007/s11136-023-03372-7 + + This study explored differences in self-reported responses and the psychometric performance of the composite EQ-5D-5L anxiety/depression (A/D) dimension compared with a split version of the dimension where 'anxiety' and 'depression' are measured separately. + People with anxiety and/or depression who visited the Amanuel Mental Specialized Hospital in Ethiopia completed the standard EQ-5D-5L with the added subdimensions. Correlation analysis was used to examine convergent validity with validated measures of depression (PHQ-9) and anxiety (GAD-7), while ANOVA was used to assess known-groups' validity. Agreement between ratings for composite and split dimensions was compared using percent agreement and Cohen's Kappa, while the proportion of 'no problems' reports was compared using the chi-square test. Discriminatory power analysis was undertaken using the Shannon index (H') and Shannon Evenness index (J'). Open-ended questions explored participants' preferences. + Of the 462 respondents, 30.5% reported no problems with the composite A/D, while 13.2% reported no problems on both subdimensions. Agreement between ratings for composite and split dimensions was highest for respondents with comorbid anxiety and depression. The depression subdimension had higher correlation with PHQ-9 (r = 0.53) and GAD-7 (r = 0.33) than the composite A/D dimension (r = 0.36 and r = 0.28, respectively). The split subdimensions and composite A/D could adequately differentiate respondents based on their severity of anxiety or depression. Slightly better informativity was observed in EQ-4D-5L + anxiety (H' = 5.4; J' = 0.47) and EQ-4D-5L + depression (H' = 5.31; J' = 0.46) than EQ-5D-5L (H' = 5.19; J' = 0.45). + Adopting two subdimensions within the EQ-5D-5L tool appears to perform slightly better than the standard EQ-5D-5L. + © 2023. The Author(s). + + + + Belay + Yared Belete + YB + http://orcid.org/0000-0001-5473-3857 + + School of Public Health and Preventive Medicine, Monash University, Level 4, 553 St Kilda Road, Melbourne, VIC, 3004, Australia. Yared.Belay1@monash.edu. + + + School of Pharmacy, Mekelle University, Mekelle, Ethiopia. Yared.Belay1@monash.edu. + + + + Mihalopoulos + Cathrine + C + + School of Public Health and Preventive Medicine, Monash University, Level 4, 553 St Kilda Road, Melbourne, VIC, 3004, Australia. + + + + Lee + Yong Yi + YY + + School of Public Health and Preventive Medicine, Monash University, Level 4, 553 St Kilda Road, Melbourne, VIC, 3004, Australia. + + + School of Public Health, The University of Queensland, Brisbane, Australia. + + + Queensland Centre for Mental Health Research, Brisbane, Australia. + + + + Mulhern + Brendan + B + + Centre for Health Economics Research and Evaluation, University of Technology Sydney, Sydney, Australia. + + + + Engel + Lidia + L + + School of Public Health and Preventive Medicine, Monash University, Level 4, 553 St Kilda Road, Melbourne, VIC, 3004, Australia. + + + + eng + + + EQ Project 229-2020RA + EuroQol Research Foundation + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Netherlands + Qual Life Res + 9210257 + 0962-9343 + + IM + + Anxiety + Composite domain + Depression + EQ-5D + Outcome measurement + +
+ + + + 2023 + 02 + 06 + + + 2023 + 2 + 22 + 13 + 47 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809437 + 10.1007/s11136-023-03372-7 + 10.1007/s11136-023-03372-7 + + + + Devlin, N. J., & Brooks, R. (2017). EQ-5D and the EuroQol group: Past, present and future. Applied health economics and health policy, 15(2), 127–137. + + 10.1007/s40258-017-0310-5 + 28194657 + 5343080 + + + + Kennedy-Martin, M., Slaap, B., Herdman, M., van Reenen, M., Kennedy-Martin, T., Greiner, W., Busschbach, J., & Boye, K. S. (2020). Which multi-attribute utility instruments are recommended for use in cost-utility analysis? A review of national health technology assessment (HTA) guidelines. The European Journal of Health Economics, 21, 1245–1257. + + 10.1007/s10198-020-01195-8 + 32514643 + 7561556 + + + + EuroQol. (2022). EQ-5D instruments – EQ-5D Retrieved 17 Jan 2022, from https://euroqol.org/eq-5d-instruments/ + + + Rencz, F., & Janssen, M. F. (2022). Analyzing the pain/discomfort and anxiety/depression composite domains and the meaning of discomfort in the EQ-5D: A mixed-methods study. Value in Health, 25(12), 2003–2016. + + 10.1016/j.jval.2022.06.012 + 35973925 + + + + Bryan, S., Jowett, S., Hardyman, W., & Bentham, P. (2004). Does the EQ-5D “anxiety/depression” item measure anxiety, depression, both or neither. EuroQol Plenary Proceedings. + + + Engel, L., Haagsma, J., Janssesn, M., Whitehurst, D., & Mulhern, D. (2020). An exploratory analysis of the pain/discomfort dimension of the EQ-5D-5L in people living with physical and mental health conditions. Paper presented at the Paper presented at the 37th Virtual EQ Plenary Meeting 2020. + + + McDonald, R., Mullett, T. L., & Tsuchiya, A. (2020). Understanding the composite dimensions of the EQ-5D: An experimental approach. Social Science & Medicine, 265, 113323. + + 10.1016/j.socscimed.2020.113323 + + + + Tsuchiya, A., Bansback, N., Hole, A. R., & Mulhern, B. (2019). Manipulating the 5 dimensions of the EuroQol instrument: The effects on self-reporting actual health and valuing hypothetical health states. Medical Decision Making, 39(4), 380–392. + + 10.1177/0272989X19851049 + + + + Brazier, J., Peasgood, T., Mukuria, C., Marten, O., Kreimeier, S., Luo, N., Mulhern, B., Pickard, A. S., Augustovski, F., & Greiner, W. (2022). The EQ Health and Wellbeing: overview of the development of a measure of health and wellbeing and key results. Value in Health, 25(4), 482–491. + + 10.1016/j.jval.2022.01.009 + 35277337 + + + + Spitzer, R. L., Kroenke, K., Williams, J. B., & Löwe, B. (2006). A brief measure for assessing generalized anxiety disorder: The GAD-7. Archives of Internal medicine, 166(10), 1092–1097. + + 10.1001/archinte.166.10.1092 + 16717171 + + + + Maurer, D. M., Raymond, T. J., & Davis, B. N. (2018). Depression: Screening and diagnosis. American family physician, 98(8), 508–515. + + 30277728 + + + + Charan, J., & Biswas, T. (2013). How to calculate sample size for different study designs in medical research? Indian journal of psychological medicine, 35(2), 121. + + 10.4103/0253-7176.116232 + 24049221 + 3775042 + + + + Rabin, R., Gudex, C., Selai, C., & Herdman, M. (2014). From translation to version management: A history and review of methods for the cultural adaptation of the EuroQol five-dimensional questionnaire. Value in health, 17(1), 70–76. + + 10.1016/j.jval.2013.10.006 + 24438719 + + + + Welie, A. G., Gebretekle, G. B., Stolk, E., Mukuria, C., Krahn, M. D., Enquoselassie, F., & Fenta, T. G. (2020). Valuing health state: An EQ-5D-5L value set for Ethiopians. Value in health regional issues, 22, 7–14. + + 10.1016/j.vhri.2019.08.475 + 31683254 + + + + Belay, Y. B., Ali, E. E., Sander, B., & Gebretekle, G. B. (2021). Health-related quality of life of patients with HIV/AIDS at a tertiary care teaching hospital in Ethiopia. Health and Quality of Life Outcomes, 19(1), 1–11. + + 10.1186/s12955-021-01670-7 + + + + Gebremariam, G. T., Biratu, S., Alemayehu, M., Welie, A. G., Beyene, K., Sander, B., & Gebretekle, G. B. (2022). Health-related quality of life of patients with type 2 diabetes mellitus at a tertiary care hospital in Ethiopia. PLoS ONE, 17(2), e0264199. + + 10.1371/journal.pone.0264199 + 35180266 + 8856533 + + + + Welie, A. G., Stolk, E., Mukuria, C., Belay, Y. B., Krahn, M. D., Sander, B., & Gebretekle, G. B. (2022). Reliability and validity of using EQ-5D-5L among healthy and adolescents with major mental health disorders in Ethiopia. The European Journal of Health Economics, 23(7), 1–15. + + 10.1007/s10198-021-01412-y + + + + McHugh, M. L. (2012). Interrater reliability: The kappa statistic. Biochemia medica, 22(3), 276–282. + + 10.11613/BM.2012.031 + 23092060 + 3900052 + + + + Schober, P., Boer, C., & Schwarte, L. A. (2018). Correlation coefficients: Appropriate use and interpretation. Anesthesia & Analgesia, 126(5), 1763–1768. + + 10.1213/ANE.0000000000002864 + + + + Cohen, J. (2013). Statistical power analysis for the behavioral sciences. Routledge. + + 10.4324/9780203771587 + + + + Janssen, M. F. B., Birnie, E., & Bonsel, G. J. (2007). Evaluating the discriminatory power of EQ-5D, HUI2 and HUI3 in a US general population survey using Shannon’s indices. Quality of life research, 16(5), 895–904. + + 10.1007/s11136-006-9160-6 + 1915610 + + + + Vaismoradi, M., Turunen, H., & Bondas, T. (2013). Content analysis and thematic analysis: Implications for conducting a qualitative descriptive study. Nursing & health sciences, 15(3), 398–405. + + 10.1111/nhs.12048 + + + + Franklin, M., Enrique, A., Palacios, J., & Richards, D. (2021). Psychometric assessment of EQ-5D-5L and ReQoL measures in patients with anxiety and depression: construct validity and responsiveness. Quality of Life Research, 30(9), 1–15. + + 10.1007/s11136-021-02833-1 + + + + Bilbao, A., Martín-Fernández, J., García-Pérez, L., Mendezona, J. I., Arrasate, M., Candela, R., Acosta, F. J., Estebanez, S., & Retolaza, A. (2021). Psychometric properties of the EQ-5D-5L in patients with major depression: Factor analysis and Rasch analysis. Journal of Mental Health, 13(3), 1–11. + + + Short, H., Al Sayah, F., Ohinmaa, A., & Johnson, J. A. (2021). The performance of the EQ-5D-3L in screening for anxiety and depressive symptoms in hospital and community settings. Health and Quality of Life Outcomes, 19(1), 1–12. + + 10.1186/s12955-021-01731-x + + + + Bansback, N., Hole, A. R., Mulhern, B., & Tsuchiya, A. (2014). Testing a discrete choice experiment including duration to value health states for large descriptive systems: Addressing design and sampling issues. Social science & medicine, 114, 38–48. + + 10.1016/j.socscimed.2014.05.026 + + + + +
+ + + 36809435 + + 2023 + 02 + 22 + +
+ + 1432-1084 + + + 2023 + Feb + 21 + + + European radiology + Eur Radiol + + Phantom-based radiomics feature test-retest stability analysis on photon-counting detector CT. + 10.1007/s00330-023-09460-z + + Radiomics image data analysis offers promising approaches in research but has not been implemented in clinical practice yet, partly due to the instability of many parameters. The aim of this study is to evaluate the stability of radiomics analysis on phantom scans with photon-counting detector CT (PCCT). + Photon-counting CT scans of organic phantoms consisting of 4 apples, kiwis, limes, and onions each were performed at 10 mAs, 50 mAs, and 100 mAs with 120-kV tube current. The phantoms were segmented semi-automatically and original radiomics parameters were extracted. This was followed by statistical analysis including concordance correlation coefficients (CCC), intraclass correlation coefficients (ICC), as well as random forest (RF) analysis, and cluster analysis to determine the stable and important parameters. + Seventy-three of the 104 (70%) extracted features showed excellent stability with a CCC value > 0.9 when compared in a test and retest analysis, and 68 features (65.4%) were stable compared to the original in a rescan after repositioning. Between the test scans with different mAs values, 78 (75%) features were rated with excellent stability. Eight radiomics features were identified that had an ICC value greater than 0.75 in at least 3 of 4 groups when comparing the different phantoms in a phantom group. In addition, the RF analysis identified many features that are important for distinguishing the phantom groups. + Radiomics analysis using PCCT data provides high feature stability on organic phantoms, which may facilitate the implementation of radiomics analysis likewise in clinical routine. + • Radiomics analysis using photon-counting computed tomography provides high feature stability. • Photon-counting computed tomography may pave the way for implementation of radiomics analysis in clinical routine. + © 2023. The Author(s). + + + + Hertel + Alexander + A + + Department of Radiology and Nuclear Medicine, University Medical Center Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany. + + + + Tharmaseelan + Hishan + H + + Department of Radiology and Nuclear Medicine, University Medical Center Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany. + + + + Rotkopf + Lukas T + LT + + Department of Radiology and Nuclear Medicine, University Medical Center Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany. + + + Department of Radiology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. + + + + Nörenberg + Dominik + D + + Department of Radiology and Nuclear Medicine, University Medical Center Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany. + + + + Riffel + Philipp + P + + Department of Radiology and Nuclear Medicine, University Medical Center Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany. + + + + Nikolaou + Konstantin + K + + Department of Diagnostic and Interventional Radiology, University of Tübingen, Hoppe-Seyler-Straße 3, 72076, Tübingen, Germany. + + + + Weiss + Jakob + J + + Department of Diagnostic and Interventional Radiology, Medial Center-University of Freiburg, Hugstetter Str. 55, 79106, Freiburg Im Breisgau, Germany. + + + + Bamberg + Fabian + F + + Department of Diagnostic and Interventional Radiology, Medial Center-University of Freiburg, Hugstetter Str. 55, 79106, Freiburg Im Breisgau, Germany. + + + + Schoenberg + Stefan O + SO + + Department of Radiology and Nuclear Medicine, University Medical Center Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany. + + + + Froelich + Matthias F + MF + + Department of Radiology and Nuclear Medicine, University Medical Center Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany. Matthias.froelich@medma.uni-heidelberg.de. + + + + Ayx + Isabelle + I + + Department of Radiology and Nuclear Medicine, University Medical Center Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Eur Radiol + 9114774 + 0938-7994 + + IM + + Data science + Radiology + Tomography, X-ray computed + +
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+ + + 36809449 + + 2023 + 02 + 22 + +
+ + 1747-4892 + + 21 + 4 + + 2022 + + + Acute medicine + Acute Med + + Co-design of interventions to improve acute care in hospital: A rapid review of the literature and application of the BASE methodology, a novel system for the design of patient centered service prototypes. + + 182-189 + + 10.52964/AMJA.0922 + + Co-design in acute care is challenged by the inability of unwell patients to participate in the process and the often transient nature of acute care. We undertook a rapid review of the literature on co-design, co-production and co-creation of solutions for acute care that were developed with patients. We found limited little evidence for co-design methods in acute care. We adapted a novel design driven method (BASE methodology) that creates stakeholder groups through epistemological criteria for the rapid development of interventions for acute care. We demonstrated feasibility of the methodology in two case studies: A mHealth application with checklists for patients undergoing treatment for cancer and a patient held record for self-clerking on admission to hospital. + + + + Subbe + C P + CP + + DM, FRCP, Ysbyty Gwynedd, Bangor and Senior Clinical Lecturer, School of Medical Sciences, Bangor University, Bangor LL57 2DG, UK. + + + + Goodman + A + A + + Senior Lecturer in Design, Bangor University, Bangor, Gwynedd, LL57 2DG. + + + + Barach + P + P + + Clinical Professor, Children's Hospital of Michigan, Wayne State University School of Medicine, 3901 Beaubien Blvd, Detroit, MI 48201, USA. + + + + eng + + Journal Article + +
+ + England + Acute Med + 101553725 + 1747-4884 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 48 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809449 + 10.52964/AMJA.0922 + + +
+ + + 36809447 + + 2023 + 02 + 22 + +
+ + 1747-4892 + + 21 + 4 + + 2022 + + + Acute medicine + Acute Med + + Patient Characteristics and Variables Influencing Acute Medical Flow. + + 168-175 + + 10.52964/AMJA.0920 + + Waiting times are the most widely used indicator of patient flow. This project aims to analyse 24-hour variation in referrals and waiting times for patients referred to the Acute Medical Service (AMS). A retrospective cohort study was conducted at the AMS of Wales' largest hospital. Collected data included patient characteristics, referral times, waiting times and adherence to Clinical Quality Indicators (CQIs). Peak referral times were found between 11:00-19:00. Peak waiting times occurred between 17:00-01:00, which was longer on weekdays in comparison to weekends. Referrals between 17:00-21:00 had the longest waiting times with > 40% of patients failing both junior and senior CQIs. Mean and median age and NEWS were higher between 17:00-09:00. Weekday evening and nights are problematic for acute medical patient flow. Interventions, including workforce, should be targeted towards these findings. + + + + Wood + C H + CH + + School of Medicine, Cardiff University, UK, CF14 4YS. + + + + Underwood + J + J + + Department of Infectious Diseases, Cardiff and Vale University Health Board. + + + + Davies + C + C + + Acute Medicine Service Manager, Cardiff and Vale University Healthy Board. + + + + Taylor + P N + PN + + Thyroid Research Group, Institute of Molecular & Experimental Medicine, Cardiff University School of Medicine, Cardiff, CF14 4YS. + + + + eng + + Journal Article + +
+ + England + Acute Med + 101553725 + 1747-4884 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 48 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809447 + 10.52964/AMJA.0920 + + +
+ + + 36809440 + + 2023 + 02 + 22 + +
+ + 1932-6203 + + 18 + 2 + + 2023 + + + PloS one + PLoS One + + Cerebral cortical thinning in Parkinson's disease depends on the age of onset. + + e0281987 + + 10.1371/journal.pone.0281987 + + Patients with older-onset Parkinson's disease (PD) have more severe motor symptoms, faster progression, and a worse prognosis. The thinning of the cerebral cortex is one of the causes of these issues. Patients with older-onset PD manifest more extended neurodegeneration associated with α-synuclein deposition in the cerebral cortex; however, the cortical regions that undergo thinning are unclear. We aimed to identify cortical regions with different thinning depending on the age of onset in patients with PD. Sixty-two patients with PD were included in this study. Patients with PD onset at <63 years old were included in the early or middle-onset PD group, and those with PD onset at >63 years old were included in the late-onset PD (LOPD) group. Brain magnetic resonance imaging data of these patients were processed using FreeSurfer to measure their cortical thickness. The LOPD group displayed less cortical thickness in the superior frontal gyrus, middle frontal gyrus, precentral gyrus, postcentral gyrus, superior temporal gyrus, temporal pole, paracentral lobule, superior parietal lobule, precuneus, and occipital lobe than the early or middle-onset PD group. Compared with patients with early and middle-onset PD, elderly patients displayed extended cortical thinning with disease progression. Differences in the clinical manifestations of PD according to the age of onset were partly due to variations in the morphological changes in the brain. + Copyright: © 2023 Seo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Seo + Kazuhide + K + https://orcid.org/0000-0003-1336-3276 + + Department of Neurology, Saitama Medical University, Saitama, Japan. + + + + Matunari + Ichiro + I + + Department of Radiology, Division of Nuclear Medicine, Saitama Medical University, Saitama, Japan. + + + + Yamamoto + Toshimasa + T + + Department of Neurology, Saitama Medical University, Saitama, Japan. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2021 + 10 + 17 + + + 2023 + 02 + 06 + + + 2023 + 2 + 22 + 13 + 47 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809440 + 10.1371/journal.pone.0281987 + PONE-D-21-33205 + + +
+ + + 36809444 + + 2023 + 02 + 22 + +
+ + 1932-6203 + + 18 + 2 + + 2023 + + + PloS one + PLoS One + + Expression of Concern: The Complete Mitochondrial Genome of the Foodborne Parasitic Pathogen Cyclospora cayetanensis. + + e0282228 + + 10.1371/journal.pone.0282228 + + + PLOS ONE Editors + + + eng + + Journal Article + Expression of Concern + + + 2023 + 02 + 21 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + + + PLoS One. 2015 Jun 04;10(6):e0128645 + 26042787 + + +
+ + + + 2023 + 2 + 22 + 13 + 48 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809444 + 10.1371/journal.pone.0282228 + PONE-D-23-04190 + + +
+ + + 36809441 + + 2023 + 02 + 22 + +
+ + 1932-6203 + + 18 + 2 + + 2023 + + + PloS one + PLoS One + + Epidemiology of dengue, chikungunya and Zika virus infections in travellers: A 16-year retrospective descriptive study at a tertiary care centre in Prague, Czech Republic. + + e0281612 + + 10.1371/journal.pone.0281612 + + This study aims to describe the epidemiological characteristics of imported cases of dengue (DEN), chikungunya (CHIK), and Zika virus (ZIKV) infections in Czech travellers. + This single-centre descriptive study has retrospectively analysed data of patients with laboratory confirmed DEN, CHIK, and ZIKV infections diagnosed at the Department of Infectious, Parasitic and Tropical Diseases of the University Hospital Bulovka in Prague, Czech Republic from 2004 to 2019. + The study included a total of 313 patients with DEN, 30 with CHIK, and 19 with ZIKV infections. Most patients travelled as tourists:263 (84.0%), 28 (93.3%), and 17 (89.5%), respectively (p = 0.337). The median duration of stay was 20 (IQR 14-27), 21 (IQR 14-29), and 15 days (IQR 14-43), respectively (p = 0.935). Peaks of imported DEN and ZIKV infections were noted in 2016, and in 2019 in the case of CHIK infection. Most cases of DEN and CHIKV infections were acquired in Southeast Asia:212 (67.7%) and 15 (50%), respectively, while ZIKV infection was most commonly imported from the Caribbean (11; 57,9%). + Arbovirus infections represent an increasingly significant cause of illness in Czech travellers. Comprehensive knowledge of the specific epidemiological profile of these diseases is an essential prerequisite for good travel medicine practice. + Copyright: © 2023 Trojánek et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Trojánek + Milan + M + https://orcid.org/0000-0003-1488-6546 + + Department of Infectious Diseases, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic. + + + Department of Infectious Diseases, University Hospital Bulovka, Prague, Czech Republic. + + + Department of Infectious Diseases and Travel Medicine, University Hospital Motol, Prague, Czech Republic. + + + + Grebenyuk + Vyacheslav + V + https://orcid.org/0000-0002-7100-0310 + + Department of Infectious Diseases, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic. + + + Department of Infectious Diseases, University Hospital Bulovka, Prague, Czech Republic. + + + Department of Infectious Diseases and Travel Medicine, University Hospital Motol, Prague, Czech Republic. + + + + Manďáková + Zdenka + Z + + Department of Epidemiology of Infectious Diseases, National Institute of Public Health, Prague, Czech Republic. + + + + Sojková + Naděžda + N + + Department of Clinical Microbiology, University Hospital Bulovka, Prague, Czech Republic. + + + + Zelená + Hana + H + https://orcid.org/0000-0002-9232-7566 + + National Reference Laboratory for Arboviruses, Institute of Public Health in Ostrava, Czech Republic. + + + + Roháčová + Hana + H + + Department of Infectious Diseases, University Hospital Bulovka, Prague, Czech Republic. + + + + Stejskal + František + F + + Department of Infectious Diseases, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic. + + + Department of Infectious Diseases, University Hospital Bulovka, Prague, Czech Republic. + + + Institute of Immunology and Microbiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic. + + + Department of Infectious Diseases, Regional Hospital Liberec, Liberec, Czech Republic. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 01 + 30 + + + 2023 + 01 + 26 + + + 2023 + 2 + 22 + 13 + 47 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809441 + 10.1371/journal.pone.0281612 + PONE-D-22-02970 + + +
+ + + 36809445 + + 2023 + 02 + 22 + +
+ + 1932-6203 + + 18 + 2 + + 2023 + + + PloS one + PLoS One + + Us vehicles sales. Evidence of persistence after COVID-19. + + e0281906 + + 10.1371/journal.pone.0281906 + + In this paper, the sales of vehicles in the US are examined to understand if the shock caused by the current COVID-19 pandemic has had permanent or transitory effects on its subsequent evolution. Using monthly data from January 1976 until April 2021 and fractional integration methods, our results indicate that the series reverts and the shocks tend to disappear in the long run, even when they appear to be long lived. The results also indicate that the COVID-19 pandemic has not increased the degree of persistence of the series but, unexpectedly, has slightly reduced its dependence. Thus, shocks are transitory, long lived but, as time goes by, the recovery seems to be faster, which is possibly a sign of the strength of the industry. + Copyright: © 2023 Lopez, Gil-Alana. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Lopez + Gema + G + + Universidad Francisco de Vitoria, Madrid, Spain. + + + + Gil-Alana + Luis Alberiko + LA + https://orcid.org/0000-0002-5760-3123 + + Universidad Francisco de Vitoria, Madrid, Spain. + + + University of Navarra, Pamplona, Spain. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 06 + 10 + + + 2023 + 02 + 02 + + + 2023 + 2 + 22 + 13 + 48 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809445 + 10.1371/journal.pone.0281906 + PONE-D-22-16653 + + +
+ + + 36809443 + + 2023 + 02 + 22 + +
+ + 1573-0646 + + + 2023 + Feb + 21 + + + Investigational new drugs + Invest New Drugs + + In vitro effects of gamma-secretase inhibition in HPV-positive and HPV-negative head and neck squamous cell carcinoma. + 10.1007/s10637-023-01334-x + + New chemotherapy agents are warranted for head and neck squamous cell carcinoma (HNSCC), particularly for incidence-rising HPV-positive tumors. Based on the evidence of Notch pathway involvement in cancer promotion and progression, we aimed to gain insights into the in vitro antineoplastic effects of gamma-secretase inhibition in HPV-positive and -negative HNSCC models. + All in vitro experiments were conducted in two HPV-negative (Cal27 and FaDu) and one HPV-associated HNSCC cell line (SCC154). The influence of the gamma-secretase inhibitor PF03084014 (PF) on proliferation, migration, colony forming, and apoptosis was assessed. + We observed significant anti-proliferative, anti-migratory, anti-clonogenic, and pro-apoptotic effects in all three HNSCC cell lines. Furthermore, synergistic effects with concomitant radiation were observable in the proliferation assay. Interestingly, effects were slightly more potent in the HPV-positive cells. + We provided novel insights into the potential therapeutic relevance of gamma-secretase inhibition in HNSCC cell lines in vitro. Therefore, PF may become a viable treatment option for patients with HNSCC, particularly for patients with HPV-induced malignancy. Indeed, further in vitro and in vivo experiments should be conducted to validate our results and decipher the mechanism behind the observed anti-neoplastic effects. + © 2023. The Author(s). + + + + Varatanovic + Sara + S + + Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria. + + + + Maier + Tobias + T + + Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria. + + + + Al-Gboore + Sega + S + + Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria. + + + + Stoiber + Stefan + S + + Department of Pathology, Medical University of Vienna, Vienna, Austria. + + + Christian Doppler Laboratory for Applied Metabolomics, Medical University of Vienna, Vienna, Austria. + + + + Kandathil + Sam Augustine + SA + + Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria. + + + Division of Anatomy, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria. + + + + Quint + Clemens + C + + Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria. + + + + Brennus + Charlotte + C + + Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria. + + + + Heiduschka + Gregor + G + + Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria. + + + + Kadletz-Wanke + Lorenz + L + + Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria. + + + + Brkic + Faris F + FF + + Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria. faris.brkic@meduniwien.ac.at. + + + + eng + + + 0007-WS 2020 + Ph.D. Martina Hamböck Grant of the Vienna Medical Chamber + + + + 19066 + Medical Scientific Fund of the Mayor of the city of Vienna + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Invest New Drugs + 8309330 + 0167-6997 + + IM + + Gamma-secretase inhibitor + Head and neck squamous cell carcinoma + Notch pathway + +
+ + + + 2023 + 01 + 02 + + + 2023 + 01 + 25 + + + 2023 + 2 + 22 + 13 + 48 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809443 + 10.1007/s10637-023-01334-x + 10.1007/s10637-023-01334-x + + + + Sturgis EM, Cinciripini PM (2007) Trends in head and neck cancer incidence in relation to smoking prevalence: an emerging epidemic of human papillomavirus-associated cancers? Cancer 110(7):1429–1435. https://doi.org/10.1002/cncr.22963 + + 10.1002/cncr.22963 + 17724670 + + + + Chow LQM (2020) Head and neck cancer. N Engl J Med 382(1):60–72. https://doi.org/10.1056/NEJMra1715715 + + 10.1056/NEJMra1715715 + 31893516 + + + + Alp AG (2012) İnsan Papillomavirusunun Genomik Yapısı ve Proteinleri [Genomic organization and proteins of human papillomavirus]. Mikrobiyol Bul 46(3):507–515 + + + Powell SF, Lexi V, Spanos WC, Pyeon D (2021) The key differences between hjuman papillomavirus-positive and -negative head and neck cancers: biological and clinical implications. Cancers (Basel) 13(20):5206. https://doi.org/10.3390/cancers13205206 + + 10.3390/cancers13205206 + 34680354 + + + + Licitra L, Perrone F, Bossi P, Suardi S, Mariani L, Artusi R, Oggionni M, Rossini C, Cantù G, Squadrelli M, Quattrone P, Locati LD, Bergamini C, Olmi P, Pierotti MA, Pilotti S (2006) High-risk human papillomavirus affects prognosis in patients with surgically treated oropharyngeal squamous cell carcinoma. J Clin Oncol 24(36):5630–5636. https://doi.org/10.1200/JCO.2005.04.6136 + + 10.1200/JCO.2005.04.6136 + 17179101 + + + + Posner MR, Lorch JH, Goloubeva O, Tan M, Schumaker LM, Sarlis NJ, Haddad RI, Cullen KJ (2011) Survival and human papillomavirus in oropharynx cancer in TAX 324: a subset analysis from an international phase III trial. Ann Oncol 22(5):1071–1077. https://doi.org/10.1093/annonc/mdr006 + + 10.1093/annonc/mdr006 + 21317223 + 4351352 + + + + Fakhry C, Westra WH, Li S, Cmelak A, Ridge JA, Pinto H, Forastiere A, Gillison ML (2008) Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. J Natl Cancer Inst 100(4):261–9. https://doi.org/10.1093/jnci/djn011 + + 10.1093/jnci/djn011 + 18270337 + + + + Seiwert TY, Zuo Z, Keck MK, Khattri A, Pedamallu CS, Stricker T, Brown C, Pugh TJ, Stojanov P, Cho J, Lawrence MS, Getz G, Brägelmann J, DeBoer R, Weichselbaum RR, Langerman A, Portugal L, Blair E, Stenson K, Lingen MW, Cohen EE, Vokes EE, White KP, Hammerman PS (2015) Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas. Clin Cancer Res 21(3):632–641. https://doi.org/10.1158/1078-0432.CCR-13-3310 + + 10.1158/1078-0432.CCR-13-3310 + 25056374 + + + + Gillison ML, D’Souza G, Westra W, Sugar E, Xiao W, Begum S, Viscidi R (2008) Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers. J Natl Cancer Inst 100(6):407–420. https://doi.org/10.1093/jnci/djn025 + + 10.1093/jnci/djn025 + 18334711 + + + + Yu W, Chen Y, Putluri N, Coarfa C, Robertson MJ, Putluri V, Stossi F, Dubrulle J, Mancini MA, Pang JC, Nguyen T, Baluya D, Myers JN, Lai SY, Sandulache VC (2020) Acquisition of cisplatin resistance shifts head and neck squamous cell carcinoma metabolism toward neutralization of oxidative stress. Cancers (Basel) 12(6):1670. https://doi.org/10.3390/cancers12061670 + + 10.3390/cancers12061670 + 32599707 + + + + Hohnloser JH, Schierl R, Hasford B, Emmerich B (1996) Cisplatin based chemotherapy in testicular cancer patients: long term platinum excretion and clinical effects. Eur J Med Res 1(11):509–514 + + 9438151 + + + + Astolfi L, Ghiselli S, Guaran V, Chicca M, Simoni E, Olivetto E, Lelli G, Martini A (2013) Correlation of adverse effects of cisplatin administration in patients affected by solid tumors: a retrospective evaluation. Oncol Rep 29(4):1285–1292. https://doi.org/10.3892/or.2013.2279 + + 10.3892/or.2013.2279 + 23404427 + 3621656 + + + + Marur S, Forastiere AA (2016) Head and neck squamous cell carcinoma: update on epidemiology, diagnosis, and treatment. Mayo Clin Proc 91(3):386–396. https://doi.org/10.1016/j.mayocp.2015.12.017 + + 10.1016/j.mayocp.2015.12.017 + 26944243 + + + + McCaw TR, Inga E, Chen H, Jaskula-Sztul R, Dudeja V, Bibb JA, Ren B, Rose JB (2021) Gamma secretase inhibitors in cancer: a current perspective on clinical performance. Oncologist 26(4):e608–e621. https://doi.org/10.1002/onco.13627 + + 10.1002/onco.13627 + 33284507 + 8018325 + + + + Li L, Tang P, Li S, Qin X, Yang H, Wu C, Liu Y (2017) Notch signaling pathway networks in cancer metastasis: a new target for cancer therapy. Med Oncol 34(10):180. https://doi.org/10.1007/s12032-017-1039-6 + + 10.1007/s12032-017-1039-6 + 28918490 + + + + Leethanakul C, Patel V, Gillespie J, Pallente M, Ensley JF, Koontongkaew S, Liotta LA, Emmert-Buck M, Gutkind JS (2000) Distinct pattern of expression of differentiation and growth-related genes in squamous cell carcinomas of the head and neck revealed by the use of laser capture microdissection and cDNA arrays. Oncogene 19(28):3220–3224. https://doi.org/10.1038/sj.onc.1203703 + + 10.1038/sj.onc.1203703 + 10918578 + + + + Fukusumi T, Califano JA (2018) The NOTCH pathway in head and neck squamous cell carcinoma. J Dent Res 97(6):645–653. https://doi.org/10.1177/0022034518760297 + + 10.1177/0022034518760297 + 29489439 + 5960881 + + + + Olsauskas-Kuprys R, Zlobin A, Osipo C (2013) Gamma secretase inhibitors of Notch signaling. Onco Targets Ther 23(6):943–955. https://doi.org/10.2147/OTT.S33766 + + 10.2147/OTT.S33766 + + + + ATCC.org, “UPCI:SCC154; FaDu; Cal27,” ATCC, [Online]. Available: https://www.atcc.org/products/crl-3241#:~:text=The%20UPCI%3ASCC154%20cell%20line,squamous%20cell%20carcinoma%20(OPSCC . Accessed 20 Oct 2022 + + + selleckchem.com, “Nirogacestat (PF03084014),” Selleckchem.com, [Online]. Available: https://www.selleckchem.com/products/pf-03084014-pf-3084014.html . Accessed 20 Oct 2022 + + + Perri F, Longo F, Caponigro F, Sandomenico F, Guida A, Della Vittoria Scarpati G, Ottaiano A, Muto P, Ionna F (2020) Management of HPV-related squamous cell carcinoma of the head and neck: pitfalls and caveat. Cancers (Basel) 12(4):975. https://doi.org/10.3390/cancers12040975 + + 10.3390/cancers12040975 + 32326465 + + + + Brkic FF, Kadletz-Wanke L, Kenner L, Füreder T, Jank B, Brunner M, Heiduschka G (2021) An analysis of distant metastasis cases from HPV-associated oropharyngeal squamous cell carcinoma. J Craniomaxillofac Surg 49(4):312–316. https://doi.org/10.1016/j.jcms.2021.01.012 + + 10.1016/j.jcms.2021.01.012 + 33612410 + + + + Brkic FF, Mayer C, Besser G, Altorjai G, Herrmann H, Heiduschka G, Haymerle G, Kadletz-Wanke L (2021) Potential association of the prognostic index and survival in patients with p16-positive oropharyngeal squamous cell carcinoma. Wien Klin Wochenschr 133(21–22):1117–1121. https://doi.org/10.1007/s00508-021-01885-0 + + 10.1007/s00508-021-01885-0 + 34143263 + 8599407 + + + + Porceddu SV, Daniels C, Yom SS, Liu H, Waldron J, Gregoire V, Moore A, Veness M, Yao M, Johansen J, Mehanna H, Rischin D, Le QT (2020) Head and Neck Cancer International Group (HNCIG) consensus guidelines for the delivery of postoperative radiation therapy in complex Cutaneous Squamous Cell Carcinoma of the Head and Neck (cSCCHN). Int J Radiat Oncol Biol Phys 107(4):641–651. https://doi.org/10.1016/j.ijrobp.2020.03.024 + + 10.1016/j.ijrobp.2020.03.024 + 32289475 + + + + Liu C, Mann D, Sinha UK, Kokot NC (2018) The molecular mechanisms of increased radiosensitivity of HPV-positive oropharyngeal squamous cell carcinoma (OPSCC): an extensive review. J Otolaryngol Head Neck Surg 47(1):59. https://doi.org/10.1186/s40463-018-0302-y + + 10.1186/s40463-018-0302-y + 30241572 + 6150985 + + + + Özcan-Wahlbrink M, Schifflers C, Riemer AB (2019) Enhanced radiation sensitivity of human papillomavirus-driven head and neck cancer: focus on immunological aspects. Front Immunol 3(10):2831. https://doi.org/10.3389/fimmu.2019.02831 + + 10.3389/fimmu.2019.02831 + + + + Bamps M, Dok R, Nuyts S (2021) The DNA damage response is differentially involved in HPV-positive and HPV-negative radioresistant head and neck squamous cell carcinoma. Cancers (Basel) 13(15):3717. https://doi.org/10.3390/cancers13153717 + + 10.3390/cancers13153717 + 34359617 + + + + Brkic FF, Stoiber S, Maier T, Gurnhofer E, Kenner L, Heiduschka G, Kadletz-Wanke L (2022) Targeting Wnt/Beta-Catenin signaling in HPV-positive head and neck squamous cell carcinoma. Pharmaceuticals (Basel) 15(3):378. https://doi.org/10.3390/ph15030378 + + 10.3390/ph15030378 + 35337176 + + + + Lan G, Lin Z, Zhang J, Liu L, Zhang J, Zheng L, Luo Q (2019) Notch pathway is involved in the suppression of colorectal cancer by embryonic stem cell microenvironment. Onco Targets Ther 16(12):2869–2878. https://doi.org/10.2147/OTT.S199046 + + 10.2147/OTT.S199046 + + + + Farah E, Li C, Cheng L, Kong Y, Lanman NA, Pascuzzi P, Lorenz GR, Zhang Y, Ahmad N, Li L, Ratliff T, Liu X (2019) NOTCH signaling is activated in and contributes to resistance in enzalutamide-resistant prostate cancer cells. J Biol Chem 294(21):8543–8554. https://doi.org/10.1074/jbc.RA118.006983 + + 10.1074/jbc.RA118.006983 + 30940724 + 6544854 + + + + Yuan CH, Filippova M, Duerksen-Hughes P (2012) Modulation of apoptotic pathways by human papillomaviruses (HPV): mechanisms and implications for therapy. Viruses 4(12):3831–3850. https://doi.org/10.3390/v4123831 + + 10.3390/v4123831 + 23250450 + 3528293 + + + + Ye QF, Zhang YC, Peng XQ, Long Z, Ming YZ, He LY (2012) Silencing Notch-1 induces apoptosis and increases the chemosensitivity of prostate cancer cells to docetaxel through Bcl-2 and Bax. Oncol Lett 3(4):879–884. https://doi.org/10.3892/ol.2012.572 + + 10.3892/ol.2012.572 + 22741011 + 3362393 + + + + Dai MY, Fang F, Zou Y, Yi X, Ding YJ, Chen C, Tao ZZ, Chen SM (2015) Downregulation of Notch1 induces apoptosis and inhibits cell proliferation and metastasis in laryngeal squamous cell carcinoma. Oncol Rep 34(6):3111–3119. https://doi.org/10.3892/or.2015.4274 + + 10.3892/or.2015.4274 + 26398771 + + + + +
+ + + 36809450 + + 2023 + 02 + 22 + +
+ + 1747-4892 + + 21 + 4 + + 2022 + + + Acute medicine + Acute Med + + Clinical decision making in acute medicine. + + 190-195 + + 10.52964/AMJA.0923 + + Clinical decision-making is a core skill for the practice of medicine and yet during training there is often little formal analysis of the process of clinical reasoning or instruction about how to do it better. This paper reviews the process of clinical decision-making with a particular focus on diagnostic reasoning. Aspects of psychology and philosophy are applied to the process along with consideration of potential sources of error and the steps that can be taken to minimize this. + + + + Trimble + M + M + + Clinical Reader, Centre for Medical Education, Queen's University, Belfast and Consultant in Acute Medicine, Royal Victoria Hospital, Belfast. + + + + Hennessy + K + K + + Academic Foundation Programme Doctor, Centre for Medical Education, Queen's University, Belfast. + + + + eng + + Journal Article + +
+ + England + Acute Med + 101553725 + 1747-4884 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 48 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809450 + 10.52964/AMJA.0923 + + +
+ + + 36809451 + + 2023 + 02 + 22 + +
+ + 1747-4892 + + 21 + 4 + + 2022 + + + Acute medicine + Acute Med + + Can we improve patients' physical activity levels after discharge by interventions on the Acute Medical Unit? The 'teachable moment'. + + 196-202 + + 10.52964/AMJA.0924 + + >30% of the population does less physical activity (PA) than recommended and few patients receive PA advice during a hospital admission (2,5). This study aimed to assess the feasibility of recruiting acute medical unit (AMU) in-patients and to examine the effect of delivering PA interventions to them. + In-patients who were inactive (<150mins/wk) were randomised to either a motivational interview (Long Interview, LI) or brief advice (Short Interview, SI). Participants' physical activity levels were assessed at baseline and at two follow-up consultations. + 77 participants were recruited. At 12 weeks 22/39(56.4%) participants were physically active following the LI and 15/38(39.5%) following the SI. + Recruitment and retention of patients on the AMU was straightforward. PA advice helped a high proportion of participants become physically active. + + + + Murphy + Jnf + J + + MBBS MSc SEM (University of Nottingham). + + + + Le Jeune + I + I + + BM BCh, MA (Oxon), MRCP, PhD (University of Nottingham). + + + + eng + + Journal Article + +
+ + England + Acute Med + 101553725 + 1747-4884 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 48 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809451 + 10.52964/AMJA.0924 + + +
+ + + 36809452 + + 2023 + 02 + 22 + +
+ + 1747-4892 + + 21 + 4 + + 2022 + + + Acute medicine + Acute Med + + Hypomagnesaemia Induced Reversible Cerebellar Syndrome. + + 203-204 + + 10.52964/AMJA.0925 + + Hypomagnesaemia may cause neurological symptoms as part of its presentation. This case demonstrates one such unusual example of a reversible cerebellar syndrome resulting from magnesium deficiency. An 81-year-old woman presented to the emergency department with a history of chronic tremor and other cerebellar signs. Severe hypomagnesaemia was detected within her initial biochemistry results. Correction of this deficiency led to a resolution in her symptoms. + + + + Huntington + G R + GR + + MBChB MRCP, Darent Valley Hospital, Dartford, Kent. george. + + + + eng + + Journal Article + +
+ + England + Acute Med + 101553725 + 1747-4884 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 48 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809452 + 10.52964/AMJA.0925 + + +
+ + + 36809453 + + 2023 + 02 + 22 + +
+ + 1747-4892 + + 21 + 4 + + 2022 + + + Acute medicine + Acute Med + + Technology-enabled multidisciplinary team in-reach for oral corticosteroid stewardship and optimizing care of suspected airways disease exacerbations. + + 205-206 + + 10.52964/AMJA.0926 + + Overuse of corticosteroids is an important problem not only in asthma but also the management of other airways diseases including bronchiectasis and COPD and results in associated risks of serious side effects and irreversible harm. We report a pilot using an in-reach solution to review patients, optimise their care and facilitate early discharge. We discharged >20% of our patients immediately, which is potentially a significant reduction in hospital bed use and, most importantly, through this approach we were able to establish early diagnosis and reduce inappropriate oral corticosteroid use. + + + + AlHelou + A + A + + MD MRCP, University Hospitals Birmingham - Birmingham, UK. + + + + Watson + A + A + + PhD, College of Medical and Dental Sciences, University of Birmingham, UK. + + + + Russell + K + K + + Dip HE, Cert HE, RGN, University Hospitals Birmingham - Birmingham, UK. + + + + Jones + K + K + + Dip HE, RGN, University Hospitals Birmingham - Birmingham, UK. + + + + Johnson + H + H + + Dip HE, RGN, University Hospitals Birmingham - Birmingham, UK. + + + + Chellappah + G + G + + MD MRCP, University Hospitals Birmingham - Birmingham, UK. + + + + Mukherjee + R + R + + MRCP, DTM&H FCCP FRCP, University Hospitals Birmingham - Birmingham, UK. + + + + eng + + Journal Article + +
+ + England + Acute Med + 101553725 + 1747-4884 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 48 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809453 + 10.52964/AMJA.0926 + + +
+ + + 36809456 + + 2023 + 02 + 22 + +
+ + 1861-6429 + + + 2023 + Feb + 21 + + + International journal of computer assisted radiology and surgery + Int J Comput Assist Radiol Surg + + Surgery assistance system for continuous resection of brain tumors-proposal of continuous tumor resection forceps, tumor cell separation, dehydration, and isolation mechanism. + 10.1007/s11548-023-02845-x + + The tumor resection ratio must be improved due the increased possibility of recurrence or malignancy. The purpose of this study was to develop a system that includes forceps with a continuous suction function and flow cytometry to diagnose the malignancy of the tumor for safe, accurate, and effective surgery. A newly developed continuous tumor resection forceps consists of a triple pipe structure, which enables continuous suction of the tumor by integrating the reflux water and suction system. The forceps includes tip opening/closure detection switch to control the adsorption and suction strength when tip is opened and closed. To perform accurate tumor diagnosis using flow cytometry, a filtering mechanism was developed for dehydrating reflux water from continuous suction forceps. In addition, a cell isolation mechanism comprising a roller pump and shear force loading mechanism was also newly developed. By using a triple pipe structure, a significantly larger tumor collection ratio was observed compared to the previous double-pipe structure. By performing suction pressure control with the opening/closure detection switch, inaccurate suction can be prevented. By widening the filter area of dehydration mechanism, it was possible to improve the reflux water dehydration ratio. The most appropriate filter area was 85 mm2. By using a newly developed cell isolation mechanism, the processing time can be reduced to less than 1/10 of the original time, keeping the same cell isolation ratio, when compared to the existing pipetting method. Neurosurgery assistance system with continuous tumor resection forceps and a cell separation, dehydration and isolation mechanism was developed. An effective and safe tumor resection, accurate and fast diagnosis of malignancy can be achieved by using the current system. + © 2023. The Author(s). + + + + Koguchi + Taro + T + + Department of Bio-Science and Engineering, Shibaura Institute of Technology, 307 Fukasaku, Minuma-ku, Saitama, 337-8570, Japan. + + + + Shimizu + Funika + F + + Department of Bio-Science and Engineering, Shibaura Institute of Technology, 307 Fukasaku, Minuma-ku, Saitama, 337-8570, Japan. + + + + Nagame + Tomohiro + T + + Department of Bio-Science and Engineering, Shibaura Institute of Technology, 307 Fukasaku, Minuma-ku, Saitama, 337-8570, Japan. + + + + Goto + Yuka + Y + + Department of Bio-Science and Engineering, Shibaura Institute of Technology, 307 Fukasaku, Minuma-ku, Saitama, 337-8570, Japan. + + + + Iwasaki + Hikaru + H + + Department of Bio-Science and Engineering, Shibaura Institute of Technology, 307 Fukasaku, Minuma-ku, Saitama, 337-8570, Japan. + + + + Hanafusa + Akihiko + A + http://orcid.org/0000-0002-1437-8202 + + Department of Bio-Science and Engineering, Shibaura Institute of Technology, 307 Fukasaku, Minuma-ku, Saitama, 337-8570, Japan. hanafusa@shibaura-it.ac.jp. + + + + Takagi + Motoki + M + + Department of Bio-Science and Engineering, Shibaura Institute of Technology, 307 Fukasaku, Minuma-ku, Saitama, 337-8570, Japan. + + + + Mohamaddan + Shahrol + S + + Department of Bio-Science and Engineering, Shibaura Institute of Technology, 307 Fukasaku, Minuma-ku, Saitama, 337-8570, Japan. + + + + Nomura + Kenichi + K + + Cooperative Major in Advanced Biomedical Sciences, Joint Graduate School of Tokyo Women's University and Waseda University, Tokyo, Japan. + + + + Muragaki + Yoshihiro + Y + + Institute of Advanced BioMedical Engineering and Science, Tokyo Women's Medical University, Tokyo, Japan. + + + + Iseki + Hiroshi + H + + Long-Term Care Geriatric Health Facility "YUU", Saitama, Japan. + + + + Masamune + Ken + K + + Institute of Advanced BioMedical Engineering and Science, Tokyo Women's Medical University, Tokyo, Japan. + + + + Akitaya + Toyohisa + T + + Fujita Medical Instruments Co. Ltd., Tokyo, Japan. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Int J Comput Assist Radiol Surg + 101499225 + 1861-6410 + + IM + + Brain tumor + Cell isolation mechanism + Continuous tumor resection forceps + Flow cytometer + Reflux water + +
+ + + + 2022 + 01 + 28 + + + 2023 + 01 + 24 + + + 2023 + 2 + 22 + 13 + 48 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809456 + 10.1007/s11548-023-02845-x + 10.1007/s11548-023-02845-x + + + + Shioyama T, Suzuki A, Nomura K, Kubo H, Kobayashi N, Nitta M, Maruyama T, Murakami T, Komori T, Muragaki Y (2017) Development of intraoperative flow cytometry system. Evaluation in glioma specimens. Cytom Res 27(2):9–15 + + + Miyatake S, Kajimoto Y, Aoki A, Kuroiwa T (2006) Glioma surgery using 5−ALA and navigation system. Jpn J Neurosurg 15(10):706–714 + + 10.7887/jcns.15.706 + + + + Shibui S, Nomura K (2002) Recent results of glioma therapy in Japan based on the data of brain tumor registry of Japan. Jpn J Neurosurg 11:355–361 + + 10.7887/jcns.11.355 + + + + Smith J, Chang E, Lamborn K, Chang S, Prados M, Cha S, Tihan T, Vandenberg S, Mcdermott M, Berger M (2008) Role of extent of resection in the long-term outcome of low-grade hemispheric gliomas. J Clin Oncol 26:1338–1345 + + 10.1200/JCO.2007.13.9337 + 18323558 + + + + Chaichana K, Torres I, Ramirez R, Raza S, Gallego M, Ibrahim A, Hermann M, Gomez L, Ye X, Weingart J, Olivi A, Blakeley J, Gallia G, Lim M, Brem H, Quinones-Hinojosa A (2014) Establishing percent resection and residual volume thresholds affecting survival and recurrence for patients with newly diagnosed intracranial glioblastoma. Neuro Oncol 16:113–122 + + 10.1093/neuonc/not137 + 24285550 + + + + Ito K, Kawano J, Takahashi T, Kawamoto M, Maki O (1996) Intraoperative diagnosis. the reason of restricted indication and suggestion. J Nippon Med Sch 63:495–498 + + 10.1272/jnms1923.63.495 + + + + Doi K (1989) Application and significance of rapid cytological diagnosis of brain tumors during surgerycomparison with final histological diagnosis. Jun Med J 34:537–550 + + + James S (2012) The SAGES manual on the fundamental use of surgical energy. Cavitron ultrasonic surgical aspirator. Springer, New York, pp 133–138 + + + Christian K, Balog J, Szaniszló T, Szalay D, Mezey G, Dénes J, Bognár L, Oertel M, Takáts Z (2011) Real time analysis of brain tissue by direct combination of ultrasonic surgical aspiration and sonic spray mass spectrometry. Anal Chem 83:7729–7735 + + 10.1021/ac201251s + + + + Parviz D, Eichberg D, Golby A, Zamani A, Laws E (2016) Multimodal navigation in endoscopic transsphenoidal resection of pituitary tumors using image-based vascular and cranial nerve segmentation: a prospective validation study. World Neurosurg 95:406–413 + + 10.1016/j.wneu.2016.06.008 + + + + Mukae N, Mizoguchi M, Mori M, Hashiguchi K, Kawaguchi M, Hata N, Amano T, Nakamizo A, Yoshimoto K, Sayama T, Iihara K, Hashizume M (2017) The usefulness of arcuate fasciculus tractography integrated navigation for glioma surgery near the language area. Clin Investig Interdiscip Neurosurg: Adv Tech Case Manage 7:22–28 + + + Li Z, Wang M, Zhang L, Fan X, Tao X, Qi L, Ling M, Xiao X, Wu Y, Guo D, Qiao H (2018) Neuronavigation-guided corticospinal tract mapping in brainstem tumor surgery: better preservation of motor function. World Neurosurg 116:E291–E297 + + 10.1016/j.wneu.2018.04.189 + 29733992 + + + + Shimizu F., Hanafusa A., Masamune K., Muragaki Y., Iseki H., (2016) Development of forceps with continuous suction function for resecting brain tumors, In: Proceedings of the 30th International Congress and Exhibition (CARS2016), p S248 + + + Koguchi T, Hanafusa A, Shimizu F, Masamune K, Muragaki Y, Iseki H (2018) Surgery assistance system for continuous resection of brain tumors. Int J Comput Assist Radiol Surg 13(Suppl. 1):S240–S241 + + + Nagame T., Hanafusa A., Koguchi T., Shimizu F., Masamune K., Muragaki Y., Iseki H., Nomura K., (2019) Development of brain surgery assistance system that integrates a tumor cell isolation device with forceps with continuous tumor resection function, 14, Suppl.1, S153–S154 + + + Goto Y, Hanafusa A, Takagi M, Nomura K, Muragaki Y, Iseki H, Masamune K (2020) Surgery assistance systems for continuous resection of brain tumors - improvement of cell isolation devices. Jpn J Comput Aided Surg 22(4):324 + + + +
+ + + 36809455 + + 2023 + 02 + 22 + +
+ + 1463-9084 + + + 2023 + Feb + 21 + + + Physical chemistry chemical physics : PCCP + Phys Chem Chem Phys + + Effect of pressure on the electronic structure of antiferromagnetic and paramagnetic YNiO3: the role of disproportionation. + 10.1039/d2cp05618f + + The dependence of electronic properties of quantum materials on external controls (e.g., pressure and temperature) is one of the fundamentals of neuromorphic computing, sensors, etc. Until recently, it has been believed that the theoretical description of such compounds cannot be accomplished using "traditional" density functional theory, and more advanced methods like dynamic mean-field theory should be utilized instead. Focusing here on the example of long-range ordered antiferromagnetic and paramagnetic YNiO3 phases, we show the interplay between spin and structural motifs under pressure and their impact on electronic properties. We successfully describe the insulating nature of both YNiO3 phases and the role of symmetry-breaking motifs in the band gap opening. Moreover, by analyzing the pressure-dependent distribution of local motifs, we show that external pressure can significantly reduce the band gap energy of both phases, originating from the reduction of structural and magnetic disproportionation - change in the distribution of local motifs. These results thus demonstrate that some of the experimental observations in quantum materials (e.g., YNiO3 compounds) can be fully understood without accounting for dynamic correlation. + + + + Wlazło + Mateusz + M + http://orcid.org/0000-0001-5493-3154 + + ENSEMBLE3 Centre of Excellence, Wolczynska 133, 01-919 Warsaw, Poland. oleksandrmalyi@gmail.com. + + + + Malyi + Oleksandr I + OI + http://orcid.org/0000-0002-2366-2838 + + ENSEMBLE3 Centre of Excellence, Wolczynska 133, 01-919 Warsaw, Poland. oleksandrmalyi@gmail.com. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Phys Chem Chem Phys + 100888160 + 1463-9076 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 48 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809455 + 10.1039/d2cp05618f + + +
+ + + 36809454 + + 2023 + 02 + 22 + +
+ + 2520-8934 + + 6 + 1 + + 2023 + Feb + 21 + + + CVIR endovascular + CVIR Endovasc + + A technical review of bail-out procedures to place Najuta stent-graft into the ascending aorta. + + 7 + + 10.1186/s42155-023-00351-4 + + The Najuta stent-graft (Kawasumi Laboratories Inc., Tokyo, Japan) is usually easily advanced to the correct deployment position in the ascending aorta thanks to the pre-curved delivery J-sheath with all fenestrations automatically oriented towards the supra-aortic vessels. Aortic arch anatomy and delivery system stiffness could however represent limitations for proper endograft advancement, especially when the aortic arch bends sharply. The aim of this technical note is to report a series of bail-out procedures that could be useful to overcome the difficulties encountered during the Najuta stent-graft advancement up to the ascending aorta. + The insertion, positioning and deployment of a Najuta stent-graft requires a through-and-through guidewire technique using a .035″ 400 cm hydrophilic nitinol guidewire (Radifocus™ Guidewire M Non-Vascular, Terumo Corporation, Tokyo, Japan) with right brachial and both femoral accesses. When standard maneuver to put the endograft tip into the aortic arch, some bail-out procedures can be applied to obtain proper positioning. Five techniques are described into the text: positioning of a coaxial extra-stiff guidewire; positioning of a long introducer sheath down to the aortic root from the right brachial access; inflation of a balloon inside the ostia of the supra-aortic vessels; inflation of a balloon inside the aortic arch (coaxial to the device); and transapical access technique. This is a troubleshooting guide for allowing physicians to overcome various difficulties with the Najuta endograft as well as for other similar devices. + Technical issues in advancing the delivery system of Najuta stent-graft could occur. Therefore, the rescue procedures described in this technical note could be useful to guarantee the correct positioning and deployment of the stent-graft. + © 2023. The Author(s). + + + + Berchiolli + Raffaella + R + + Vascular Surgery Unit, Department of Translational Research and of New Technologies in Medicine and Surgery, University of Pisa, Cisanello Hospital, Via Roma 67, 56126, Pisa, Italy. + + + + Troisi + Nicola + N + http://orcid.org/0000-0002-8779-9120 + + Vascular Surgery Unit, Department of Translational Research and of New Technologies in Medicine and Surgery, University of Pisa, Cisanello Hospital, Via Roma 67, 56126, Pisa, Italy. nicola.troisi@unipi.it. + + + + Bertagna + Giulia + G + + Vascular Surgery Unit, Department of Translational Research and of New Technologies in Medicine and Surgery, University of Pisa, Cisanello Hospital, Via Roma 67, 56126, Pisa, Italy. + + + + Colli + Andrea + A + + Division of Cardiac Surgery, Department of Surgical, Medical and Molecular Pathology and Critical Care, University of Pisa, Pisa, Italy. + + + + Besola + Laura + L + + Division of Cardiac Surgery, Department of Surgical, Medical and Molecular Pathology and Critical Care, University of Pisa, Pisa, Italy. + + + + Silingardi + Roberto + R + + Department of Vascular Surgery, University of Modena and Reggio Emilia, Nuovo Ospedale S. Agostino Estense, Modena, Italy. + + + + Simonte + Gioele + G + + Department of Vascular and Endovascular Surgery, University Hospital of Perugia, Perugia, Italy. + + + + Isernia + Giacomo + G + + Department of Vascular and Endovascular Surgery, University Hospital of Perugia, Perugia, Italy. + + + + Italian Najuta registry collaborators + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Switzerland + CVIR Endovasc + 101738484 + 2520-8934 + + + Aortic arch + Najuta stent-graft + Thoracic endovascular aortic repair (TEVAR) + + + + Orrico + Matteo + M + + + Lenti + Massimo + M + + + Parlani + Gianbattista + G + + + Fino + Gianluigi + G + + + Covic + Tea + T + + + Gennai + Stefano + S + + + Ferri + Michelangelo + M + + + Ferrero + Emanuele + E + + + Quaglino + Simone + S + + + Rizza + Antonio + A + + + Maritati + Gabriele + G + + + Portoghese + Michele + M + + + Verzini + Fabio + F + + + Discalzi + Andrea + A + + + Pulli + Raffaele + R + + + Fargion + Aaron + A + + + Bonvini + Stefano + S + + + Intrieri + Francesco + F + + + Speziale + Francesco + F + + + Mansour + Wassim + W + + + Moniaci + Diego + D + + + Troisi + Nicola + N + + + Colli + Andrea + A + + + Camparini + Stefano + S + + + Genavi + Genadiev + G + + + Pratesi + Giovanni + G + + + Massi + Francesco + F + + + Michelagnoli + Stefano + S + + + Chisci + Emiliano + E + + + Bonardelli + Stefano + S + + + Maione + Massimo + M + + + Angiletta + Domenico + D + + + Zacà + Sergio + S + + + Veraldi + Gian Franco + GF + + + Mezzetto + Luca + L + + +
+ + + + 2022 + 12 + 16 + + + 2023 + 01 + 23 + + + 2023 + 2 + 22 + 13 + 48 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809454 + 10.1186/s42155-023-00351-4 + 10.1186/s42155-023-00351-4 + + + + Blanco Amil CL, Mestres Alomar G, Guarnaccia G, Luoni G, Yugueros Castellnou X, Vigliotti RC et al (2021) The initial experience on branched and fenestrated Endografts in the aortic arch. A systematic review. Ann Vasc Surg 75:29–44 + + 10.1016/j.avsg.2021.03.024 + 33831530 + + + + Colli A, Manzan E, Fabio FZ, Sarais C, Pittarello D, Speziali G et al (2014) TEE-guided transapical beating-heart neochord implantation in mitral regurgitation. JACC Cardiovasc Imaging 7:322–323 + + 10.1016/j.jcmg.2014.01.003 + 24651110 + + + + Fernández-Alonso L, Fernández Alonso S, Martínez Aguilar E, Santamarta Fariña E, Alegret Solé J, Atienza Pascual M et al (2020) Fenestrated and scalloped endovascular grafts in zone 0 and zone 1 for aortic arch disease. Ann Vasc Surg 69:360–365 + + 10.1016/j.avsg.2020.06.009 + 32554200 + + + + Isernia G, Simonte G, Orrico M, Silingardi R, Gaggiano A, Covic T et al (2023) Preliminary results from an Italian National Registry on the outcomes of the Najuta fenestrated aortic arch endograft. J Vasc Surg 2023. https://doi.org/10.1016/j.jvs.2022.12.059 in press + + + Mastrorilli D, Mezzetto L, Scorsone L, Leone N, Gennai S, Veraldi E et al (2022) Sheath-anchoring for rail guidewire technique to advance and deploy thoracic endograft in hostile anatomy. Ann Vasc Surg 80:393 + + 10.1016/j.avsg.2021.09.033 + + + + Prendes CF, Banafsche R, Stana J, Binskin R, Konstantinou N, Kölbel T et al (2021) Technical aspects of fenestrated arch TEVAR with preloaded fenestration. J Endovasc Ther 28:510–518 + + 10.1177/15266028211007469 + 33834906 + + + + Sato H, Fukada J, Tamiya Y, Mikami T, Sibata T, Harada R et al (2020) Long-term clinical outcomes of thoracic endovascular aortic repair for arch aneurysms with the Najuta thoracic stent-graft system. Ann Vasc Dis 13:384–389 + + 10.3400/avd.oa.20-00102 + 33391555 + 7758573 + + + + Toya N, Ohki T, Fukushima S, Shukuzawa K, Ito E, Murakami Y et al (2018) Case series of aortic arch aneurysm in patients with bovine arch treated with proximal scalloped and fenestrated stent graft. Cardiovasc Intervent Radiol 41:1648–1653 + + 10.1007/s00270-018-2058-1 + 30120530 + + + + +
+ + + 36809463 + + 2023 + 02 + 22 + +
+ + 1935-5548 + + + 2023 + Feb + 20 + + + Diabetes care + Diabetes Care + + Physical Activity and Insulin Sensitivity Independently Attenuate the Effect of FTO rs9939609 on Obesity. + dc222078 + 10.2337/dc22-2078 + + The association between FTO rs9939609 and obesity is modified by physical activity (PA) and/or insulin sensitivity (IS). We aimed to assess whether these modifications are independent, whether PA and/or IS modify the association between rs9939609 and cardiometabolic traits, and to elucidate underlying mechanisms. + Genetic association analyses comprised up to 19,585 individuals. PA was self-reported, and IS was defined based on inverted HOMA insulin resistance index. Functional analyses were performed in muscle biopsies from 140 men, and in cultured muscle cells. + The BMI-increasing effect of the FTO rs9939609 A allele was attenuated by 47% with high PA (β [SE], -0.32 [0.10] kg/m2, P = 0.0013), and by 51% with high IS (-0.31 [0.09] kg/m2, P = 0.00028). Interestingly, these interactions were essentially independent (PA, -0.20 [0.09] kg/m2, P = 0.023; IS, -0.28 [0.09] kg/m2, P = 0.0011). The rs9939609 A allele was also associated with higher all-cause mortality and certain cardiometabolic outcomes (hazard ratio, 1.07-1.20, P > 0.04), and these effects tended to be weakened by greater PA and IS. Moreover, the rs9939609 A allele was associated with higher expression of FTO in skeletal muscle tissue (0.03 [0.01], P = 0.011), and in skeletal muscle cells, we identified a physical interaction between the FTO promoter and an enhancer region encompassing rs9939609. + Greater PA and IS independently reduced the effect of rs9939609 on obesity. These effects might be mediated through altered expression of FTO in skeletal muscle. Our results indicated that PA and/or other means of increasing insulin sensitivity could counteract FTO-related genetic predisposition to obesity. + © 2023 by the American Diabetes Association. + + + + Andersen + Mette K + MK + 0000-0001-8227-1469 + + Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. + + + + Ängquist + Lars + L + + Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. + + + + Bork-Jensen + Jette + J + + Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. + + + + Jonsson + Anna E + AE + + Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. + + + + Stinson + Sara E + SE + 0000-0002-1491-9179 + + Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. + + + + Sandholt + Camilla H + CH + + Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. + + + + Thodberg + Malte + M + + Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. + + + + Pikkupeura + Laura Maarit + LM + + Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. + + + + Ongstad + Emily L + EL + + Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD. + + + + Grarup + Niels + N + 0000-0001-5526-1070 + + Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. + + + + Astrup + Arne + A + + Obesity and Nutrition Science, Novo Nordisk Foundation, Hellerup, Denmark. + + + + Pedersen + Oluf + O + + Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. + + + Center for Clinical Metabolic Research, Gentofte Hospital, Hellerup, Denmark. + + + + Williams + Kristine + K + + Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. + + + + Barrès + Romain + R + 0000-0002-0158-519X + + Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. + + + + Sørensen + Thorkild I A + TIA + + Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. + + + Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. + + + + Linneberg + Allan + A + + Centre for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark. + + + Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. + + + + Grimsby + Joseph + J + + Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD. + + + Regeneron Pharmaceuticals, Tarrytown, NY. + + + + Rhodes + Christopher J + CJ + + Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD. + + + + Hansen + Torben + T + 0000-0001-8748-3831 + + Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. + + + Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark. + + + + eng + + Journal Article + + + 2023 + 02 + 20 + +
+ + United States + Diabetes Care + 7805975 + 0149-5992 + + IM +
+ + + + 2022 + 10 + 24 + + + 2023 + 01 + 30 + + + 2023 + 2 + 22 + 13 + 48 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809463 + 148494 + 10.2337/dc22-2078 + + +
+ + + 36809457 + + 2023 + 02 + 22 + +
+ + 2050-7895 + + + 2023 + Feb + 21 + + + Environmental science. Processes & impacts + Environ Sci Process Impacts + + Comparison of nitrate formation mechanisms from free amino acids and amines during ozonation: a computational study. + 10.1039/d2em00501h + + Nitrate as a potential surrogate parameter for abatement of micropollutants, oxidant exposure, and characterizing oxidant-reactive DON during ozonation has attracted extensive attention, however, understanding of its formation mechanisms is still limited. In this study, nitrate formation mechanisms from amino acids (AAs) and amines during ozonation were investigated by the DFT method. The results indicate that N-ozonation initially occurs to produce competitive nitroso- and N,N-dihydroxy intermediates, and the former is preferred for both AAs and primary amines. Then, oxime and nitroalkane are generated during further ozonation, which are the important last intermediate products for nitrate formation from the respective AAs and amines. Moreover, the ozonation of the above important intermediates is the nitrate yield-controlling step, where the relatively higher reactivity of the CN moiety in the oxime compared to the general Cα atom in the nitroalkane explains why the nitrate yields of most AAs are higher than those from general amines, and it is the larger number of released Cα- anions, which are the real reaction sites attacked by ozone, that leads to the higher nitrate yield for nitroalkane with an electron-withdrawing group bound to the Cα atom. The good relationship between nitrate yields and activation free energies of the rate-limiting step (ΔG≠rls) and nitrate yield-controlling step (ΔG≠nycs) for the respective AAs and amines verifies the reliability of the proposed mechanisms. Additionally, the bond dissociation energy of Cα-H in the nitroalkanes formed from amines was found to be a good parameter to evaluate the reactivity of the amines. The findings here are helpful for further understanding nitrate formation mechanisms and predicting nitrate precursors during ozonation. + + + + Yin + Shuning + S + + Beijing Key Laboratory of Environmental and Viral Oncology, College of Life Science & Bioengineering, Beijing University of Technology, Beijing 100124, China. ydliu@bjut.edu.cn. + + + + Shen + Qunfang + Q + + Beijing Key Laboratory of Environmental and Viral Oncology, College of Life Science & Bioengineering, Beijing University of Technology, Beijing 100124, China. ydliu@bjut.edu.cn. + + + + Liu + Yong Dong + YD + http://orcid.org/0000-0002-8483-1877 + + Beijing Key Laboratory of Environmental and Viral Oncology, College of Life Science & Bioengineering, Beijing University of Technology, Beijing 100124, China. ydliu@bjut.edu.cn. + + + + Zhong + Rugang + R + + Beijing Key Laboratory of Environmental and Viral Oncology, College of Life Science & Bioengineering, Beijing University of Technology, Beijing 100124, China. ydliu@bjut.edu.cn. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Environ Sci Process Impacts + 101601576 + 2050-7887 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 48 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809457 + 10.1039/d2em00501h + + +
+ + + 36809462 + + 2023 + 02 + 22 + +
+ + 1613-9674 + + + 2023 + Feb + 21 + + + Oral radiology + Oral Radiol + + Correction to: Stiffness of tongue squamous cell carcinoma measured using strain elastography correlates with the amount of collagen fibers in the tumor. + 10.1007/s11282-023-00670-1 + + + Shibata + Mari + M + http://orcid.org/0000-0001-7497-9184 + + Department of Oral Surgery, Saitama Cancer Center, Saitama, Japan. + + + Department of Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan. + + + + Ishikawa + Ayataka + A + http://orcid.org/0000-0002-7989-2333 + + Department of Pathology, Saitama Cancer Center, Saitama, Japan. ayataka@cancer-c.pref.saitama.jp. + + + + Ishii + Junichi + J + http://orcid.org/0000-0002-9368-3925 + + Department of Oral Surgery, Saitama Cancer Center, Saitama, Japan. + + + + Anzai + Eri + E + http://orcid.org/0000-0002-6075-7537 + + Department of Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan. + + + + Yagishita + Hisao + H + http://orcid.org/0000-0003-4697-5092 + + Department of Pathology, Saitama Cancer Center, Saitama, Japan. + + + + Izumo + Toshiyuki + T + http://orcid.org/0000-0001-8601-0434 + + Department of Pathology, Saitama Cancer Center, Saitama, Japan. + + + + Sumino + Jun + J + http://orcid.org/0000-0002-2744-2146 + + Department of Oral Surgery, Saitama Cancer Center, Saitama, Japan. + + + + Katsurano + Miki + M + http://orcid.org/0000-0002-1772-1838 + + Department of Oral Surgery, Saitama Cancer Center, Saitama, Japan. + + + + Kim + Yusoon + Y + http://orcid.org/0000-0002-8304-9488 + + Department of Oral Surgery, Saitama Cancer Center, Saitama, Japan. + + + + Kanda + Hiroaki + H + http://orcid.org/0000-0002-4602-5938 + + Department of Pathology, Saitama Cancer Center, Saitama, Japan. + + + + Ushijima + Masaru + M + http://orcid.org/0000-0001-6383-8482 + + Clinical Research and Medical Development Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research (JFCR), Tokyo, Japan. + + + + Yagihara + Kazuhiro + K + http://orcid.org/0000-0002-9166-6937 + + Department of Oral Surgery, Saitama Cancer Center, Saitama, Japan. + + + + Yoda + Tetsuya + T + http://orcid.org/0000-0003-1896-8696 + + Department of Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan. + + + + eng + + Published Erratum + + + 2023 + 02 + 21 + +
+ + Japan + Oral Radiol + 8806621 + 0911-6028 + + IM + + + Oral Radiol. 2022 Apr;38(2):278-287 + 34302572 + + +
+ + + + 2023 + 2 + 22 + 13 + 48 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809462 + 10.1007/s11282-023-00670-1 + 10.1007/s11282-023-00670-1 + + +
+ + + 36809460 + + 2023 + 02 + 22 + +
+ + 1540-8140 + + 222 + 3 + + 2023 + Mar + 06 + + + The Journal of cell biology + J Cell Biol + + Judith Agudo: Beware of your inner self-immune attack. + e202302027 + 10.1083/jcb.202302027 + + Judith Agudo studies the mechanisms that adult and cancer stem cells use to evade the immune response with the goals of engineering autoimmunity- and allograft-resistant stem cells and improving the response of cancer stem cells to immunotherapy. + © 2023 Morgado-Palacin. + + + + Morgado-Palacin + Lucia + L + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + J Cell Biol + 0375356 + 0021-9525 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 48 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809460 + 213881 + 10.1083/jcb.202302027 + + +
+ + + 36809458 + + 2023 + 02 + 22 + +
+ + 1432-1327 + + + 2023 + Feb + 21 + + + Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry + J Biol Inorg Chem + + Cyanide replaces substrate in obligate-ordered addition of nitric oxide to the non-heme mononuclear iron AvMDO active site. + 10.1007/s00775-023-01990-7 + + Thiol dioxygenases are a subset of non-heme mononuclear iron oxygenases that catalyze the O2-dependent oxidation of thiol-bearing substrates to yield sulfinic acid products. Cysteine dioxygenase (CDO) and 3-mercaptopropionic acid (3MPA) dioxygenase (MDO) are the most extensively characterized members of this enzyme family. As with many non-heme mononuclear iron oxidase/oxygenases, CDO and MDO exhibit an obligate-ordered addition of organic substrate before dioxygen. As this substrate-gated O2-reactivity extends to the oxygen-surrogate, nitric oxide (NO), EPR spectroscopy has long been used to interrogate the [substrate:NO:enzyme] ternary complex. In principle, these studies can be extrapolated to provide information about transient iron-oxo intermediates produced during catalytic turnover with dioxygen. In this work, we demonstrate that cyanide mimics the native thiol-substrate in ordered-addition experiments with MDO cloned from Azotobacter vinelandii (AvMDO). Following treatment of the catalytically active Fe(II)-AvMDO with excess cyanide, addition of NO yields a low-spin (S = 1/2) (CN/NO)-Fe-complex. Continuous wave and pulsed X-band EPR characterization of this complex produced in wild-type and H157N variant AvMDO reveal multiple nuclear hyperfine features diagnostic of interactions within the first- and outer-coordination sphere of the enzymatic Fe-site. Spectroscopically validated computational models indicate simultaneous coordination of two cyanide ligands replaces the bidentate (thiol and carboxylate) coordination of 3MPA allowing for NO-binding at the catalytically relevant O2-binding site. This promiscuous substrate-gated reactivity of AvMDO with NO provides an instructive counterpoint to the high substrate-specificity exhibited by mammalian CDO for L-cysteine. + © 2023. The Author(s), under exclusive licence to Society for Biological Inorganic Chemistry (SBIC). + + + + York + Nicholas J + NJ + + Department of Chemistry and Biochemistry, University of Alabama, 250 Hackberry Lane, Tuscaloosa, AL, 35487, USA. + + + + Lockart + Molly M + MM + + Department of Chemistry and Biochemistry, Samford University, 800 Lakeshore Drive, Homewood, AL, 35229, USA. + + + + Schmittou + Allison N + AN + + Department of Chemistry and Biochemistry, University of Alabama, 250 Hackberry Lane, Tuscaloosa, AL, 35487, USA. + + + + Pierce + Brad S + BS + + Department of Chemistry and Biochemistry, University of Alabama, 250 Hackberry Lane, Tuscaloosa, AL, 35487, USA. bspierce1@ua.edu. + + + + eng + + + 2 R15 GM117511-03 + National Institute of General Medical Sciences + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + J Biol Inorg Chem + 9616326 + 0949-8257 + + IM + + Continuous wave EPR spectroscopy + DFT + HYSCORE + Non-heme iron + Thiol dioxygenase + +
+ + + + 2022 + 10 + 13 + + + 2023 + 01 + 12 + + + 2023 + 2 + 22 + 13 + 48 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809458 + 10.1007/s00775-023-01990-7 + 10.1007/s00775-023-01990-7 + + + + Dominy JE, Simmons CR, Hirschberger LL, Hwang J, Coloso RM, Stipanuk MH (2007) J Biol Chem 282:25189–25198 + + 17581819 + 10.1074/jbc.M703089200 + + + + Stipanuk M, Simmons C, Andrew Karplus A, Dominy J (2010) Amino Acids, 1–12 + + + Ewetz L, Sorbo B (1966) Biochim Biophys Acta 128:296–305 + + 4382020 + 10.1016/0926-6593(66)90176-7 + + + + Sorbo B, Ewetz L (1965) Biochem Biophys Res Commun 18:359–363 + + 10.1016/0006-291X(65)90714-X + + + + Lombardini JB, Singer TP, Boyer PD (1969) J Biol Chem 244:1172–1175 + + 5767301 + 10.1016/S0021-9258(18)91825-9 + + + + Gordon C, Emery P, Bradley H, Waring H (1992) Lancett 229:25–26 + + 10.1016/0140-6736(92)90144-R + + + + Dominy JE Jr, Simmons CR, Karplus PA, Gehring AM, Stipanuk MH (2006) J Bacteriol 188:5561–5569 + + 16855246 + 1540046 + 10.1128/JB.00291-06 + + + + Heafield MT, Fearn S, Steventon GB, Waring RH, Williams AC, Sturman SG (1990) Neurosci Lett 110:216–220 + + 2325885 + 10.1016/0304-3940(90)90814-P + + + + Sarkar B, Kulharia M, Mantha AK (2017) Int J Exp Pathol 98:52–66 + + 28439920 + 5485369 + 10.1111/iep.12222 + + + + Brown CD, Neidig ML, Neibergall MB, Lipscomb JD, Solomon EI (2007) J Am Chem Soc 129:7427–7438 + + 17506560 + 2536647 + 10.1021/ja071364v + + + + Yamaguchi K, Sakakibara S, Koga K, Ueda I (1971) Biochim Biophys Acta Gen Subj 237:502–512 + + 10.1016/0304-4165(71)90270-4 + + + + Perry TL, Norman MG, Yong VW, Whiting S, Crichton JU, Hansen S, Kish SJ (1985) Ann Neurol 18:482–489 + + 4073841 + 10.1002/ana.410180411 + + + + Bradley H, Gough A, Sokhi RS, Hassell A, Waring R, Emery P (1994) J Rheumatol 21:1192–1196 + + 7966056 + + + + Deth R, Muratore C, Benzecry J, Power-Charnitsky V-A, Waly M (2008) Neurotoxicology 29:190–201 + + 18031821 + 10.1016/j.neuro.2007.09.010 + + + + James SJ, Cutler P, Melnyk S, Jernigan S, Janak L, Gaylor DW, Neubrander JA (2004) Am J Clin Nutr 80:1611–1617 + + 15585776 + 10.1093/ajcn/80.6.1611 + + + + Reddie KG, Carroll KS (2008) Curr Opin Chem Biol 12:746–754 + + 18804173 + 10.1016/j.cbpa.2008.07.028 + + + + Winyard PG, Moody CJ, Jacob C (2005) Trends Biochem Sci 30:453–461 + + 15996871 + 10.1016/j.tibs.2005.06.001 + + + + Trachootham D, Alexandre J, Huang P (2009) Nat Rev Drug Discov 8:579–591 + + 19478820 + 10.1038/nrd2803 + + + + Behave DP, Muse WB, Carroll KS (2007) Infect Disord Drug Targets 7:140–158 + + 10.2174/187152607781001772 + + + + Gunawardana DM, Heathcote KC, Flashman E (2021) FEBS J + + + Weits DA, Giuntoli B, Kosmacz M, Parlanti S, Hubberten H-M, Riegler H, Hoefgen R, Perata P, van Dongen JT, Licausi F (2014) Nat Commun 5:3425 + + 24599061 + 10.1038/ncomms4425 + + + + White MD, Klecker M, Hopkinson RJ, Weits DA, Mueller C, Naumann C, O’Neill R, Wickens J, Yang J, Brooks-Bartlett JC, Garman EF, Grossmann TN, Dissmeyer N, Flashman E (2017) Nat Commun 8:14690 + + 28332493 + 5376641 + 10.1038/ncomms14690 + + + + Masson N, Keeley TP, Giuntoli B, White MD, Puerta ML, Perata P, Hopkinson RJ, Flashman E, Licausi F, Ratcliffe PJ (2019) Science 365:65–69 + + 31273118 + 6715447 + 10.1126/science.aaw0112 + + + + Fernandez RL, Elmendorf LD, Smith RW, Bingman CA, Fox BG, Brunold TC (2021) Biochemistry 60:3728–3737 + + 34762398 + 10.1021/acs.biochem.1c00463 + + + + Wang Y, Shin I, Li J, Liu A (2021) J Biol Chem 297:101176 + + 34508780 + 10.1016/j.jbc.2021.101176 + + + + Tchesnokov EP, Fellner M, Siakkou E, Kleffmann T, Martin LW, Aloi S, Lamont IL, Wilbanks SM, Jameson GNL (2015). J Biol Chem. https://doi.org/10.1074/jbc.M114.635672 + + 10.1074/jbc.M114.635672 + 26272617 + 4591825 + + + + Tchesnokov EP, Faponle AS, Davies CG, Quesne MG, Turner R, Fellner M, Souness RJ, Wilbanks SM, de Visser SP, Jameson GNL (2016) Chem Commun (Camb) 52:8814–8817 + + 27297454 + 10.1039/C6CC03904A + + + + Crowell JK, Sardar S, Hossain MS, Foss FW, Pierce BS (2016) Arch Biochem Biophys 604:86–94 + + 27311613 + 5036937 + 10.1016/j.abb.2016.06.009 + + + + Pierce BS, Subedi BP, Sardar S, Crowell JK (2015) Biochemistry 54:7477–7490 + + 26624219 + 10.1021/acs.biochem.5b00636 + + + + York NJ, Lockart MM, Sardar S, Khadka N, Shi W, Stenkamp RE, Zhang J, Kiser PD, Pierce BS (2021) J Biol Chem 296:100496 + + 10.1016/j.jbc.2021.100492 + + + + York NJ, Lockart MM, Pierce BS (2021) Inorg Chem 60:18639–18651 + + 34883020 + 10.1021/acs.inorgchem.1c01519 + + + + Sardar S, Weitz A, Hendrich MP, Pierce BS (2019) Biochemistry 58:5135–5150 + + 31750652 + 10.1021/acs.biochem.9b00674 + + + + Li W, Blaesi EJ, Pecore MD, Crowell JK, Pierce BS (2013) Biochemistry 52:9104–9119 + + 24279989 + 10.1021/bi4010232 + + + + Fernandez RL, Juntunen ND, Brunold TC (2022) Acc Chem Res 55:2480–2490 + + 35994511 + 10.1021/acs.accounts.2c00359 + + + + Weitz AC, Giri N, Caranto JD, Kurtz DM, Bominaar EL, Hendrich MP (2017) J Am Chem Soc 139:12009–12019 + + 28756660 + 5898632 + 10.1021/jacs.7b06546 + + + + Tierney DL, Rocklin AM, Lipscomb JD, Que L, Hoffman BM (2005) J Am Chem Soc 127:7005–7013 + + 15884944 + 10.1021/ja0500862 + + + + Casey TM, Grzyska PK, Hausinger RP, McCracken J (2013) J Phys Chem B 117:10384–10394 + + 23937570 + 10.1021/jp404743d + + + + Li J, Koto T, Davis I, Liu A (2019) Biochemistry 58:2218–2227 + + 30946568 + 10.1021/acs.biochem.9b00006 + + + + McCracken J, Eser BE, Mannikko D, Krzyaniak MD, Fitzpatrick PF (2015) Biochemistry 54:3759–3771 + + 26024204 + 10.1021/acs.biochem.5b00363 + + + + Pierce BS, Gardner JD, Bailey LJ, Brunold TC, Fox BG (2007) Biochemistry 46:8569–8578 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Rev 13:339–406 + + 10.1016/S0010-8545(00)80259-3 + + + + Lewandowska H, Kalinowska M, Brzóska K, Wójciuk K, Wójciuk G, Kruszewski M (2011) Dalton Trans 40:8273–8289 + + 21643591 + 10.1039/c0dt01244k + + + + Truzzi DR, Augusto O, Iretskii AV, Ford PC (2019) Inorg Chem 58:13446–13456 + + 31535856 + 10.1021/acs.inorgchem.9b02338 + + + + Reginato N, McCrory CTC, Pervitsky D, Li L (1999) J Am Chem Soc 121:10217–10218 + + 10.1021/ja982491h + + + + Tsai F-T, Kuo T-S, Liaw W-F (2009) J Am Chem Soc 131:3426–3427 + + 19226176 + 10.1021/ja808743g + + + + Blaesi EJ, Gardner JD, Fox BG, Brunold TC (2013) Biochemistry 52:6040–6051 + + 23906193 + 10.1021/bi400825c + + + + Li M, Bonnet D, Bill E, Neese F, Weyhermèuller T, Blum N, Sellmann D, Wieghardt K (2002) Inorg Chem 41:3444–3456 + + 12079463 + 10.1021/ic011243a + + + + Orville AM, Lipscomb JD (1997) Biochemistry 36:14044–14055 + + 9369476 + 10.1021/bi970609l + + + + Stevens TH, Chan SI (1981) J Biol Chem 256:1069–1071 + + 6256377 + 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+ + + 36809459 + + 2023 + 02 + 22 + +
+ + 1473-0189 + + + 2023 + Feb + 21 + + + Lab on a chip + Lab Chip + + High-throughput mechanophenotyping of multicellular spheroids using a microfluidic micropipette aspiration chip. + 10.1039/d2lc01060g + + Cell spheroids are in vitro multicellular model systems that mimic the crowded micro-environment of biological tissues. Their mechanical characterization can provide valuable insights in how single-cell mechanics and cell-cell interactions control tissue mechanics and self-organization. However, most measurement techniques are limited to probing one spheroid at a time, require specialized equipment and are difficult to handle. Here, we developed a microfluidic chip that follows the concept of glass capillary micropipette aspiration in order to quantify the viscoelastic behavior of spheroids in an easy-to-handle, more high-throughput manner. Spheroids are loaded in parallel pockets via a gentle flow, after which spheroid tongues are aspirated into adjacent aspiration channels using hydrostatic pressure. After each experiment, the spheroids are easily removed from the chip by reversing the pressure and new spheroids can be injected. The presence of multiple pockets with a uniform aspiration pressure, combined with the ease to conduct successive experiments, allows for a high throughput of tens of spheroids per day. We demonstrate that the chip provides accurate deformation data when working at different aspiration pressures. Lastly, we measure the viscoelastic properties of spheroids made of different cell lines and show how these are consistent with previous studies using established experimental techniques. In summary, our chip provides a high-throughput way to measure the viscoelastic deformation behavior of cell spheroids, in order to mechanophenotype different tissue types and examine the link between cell-intrinsic properties and overall tissue behavior. + + + + Boot + Ruben C + RC + http://orcid.org/0000-0003-4003-8276 + + Department of Chemical Engineering, Delft University of Technology, Delft, The Netherlands. p.e.boukany@tudelft.nl. + + + + Roscani + Alessio + A + + Department of Chemical Engineering, Delft University of Technology, Delft, The Netherlands. p.e.boukany@tudelft.nl. + + + + van Buren + Lennard + L + + Department of Bionanoscience, Kavli Institute of Nanoscience Delft, Delft University of Technology, Delft, The Netherlands. + + + + Maity + Samadarshi + S + http://orcid.org/0000-0001-8368-6957 + + Department of Chemical Engineering, Delft University of Technology, Delft, The Netherlands. p.e.boukany@tudelft.nl. + + + + Koenderink + Gijsje H + GH + http://orcid.org/0000-0002-7823-8807 + + Department of Bionanoscience, Kavli Institute of Nanoscience Delft, Delft University of Technology, Delft, The Netherlands. + + + + Boukany + Pouyan E + PE + http://orcid.org/0000-0002-2262-5795 + + Department of Chemical Engineering, Delft University of Technology, Delft, The Netherlands. p.e.boukany@tudelft.nl. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Lab Chip + 101128948 + 1473-0189 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 48 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809459 + 10.1039/d2lc01060g + + +
+ + + 36809461 + + 2023 + 02 + 22 + +
+ + 1573-4935 + + + 2023 + Feb + 21 + + + Bioscience reports + Biosci Rep + + CRISPR-Cas adaptation in Escherichia coli. + BSR20221198 + 10.1042/BSR20221198 + + Prokaryotes use the adaptive immunity mediated via the Clustered Regularly Interspaced Short Palindromic Repeat and CRISPR associated (CRISPR-Cas) system for protection against invading elements such as phages and plasmids. The immunity is achieved by capturing small DNA fragments or spacers from foreign nucleic acids (protospacers) and integrating them into the host CRISPR locus. This step of CRISPR-Cas immunity called 'naïve CRISPR adaptation' requires the conserved Cas1-Cas2 complex and is often supported by variable host proteins that assist in spacer processing and integration. Bacteria that have acquired new spacers become immune to the same invading elements when reinfected. CRISPR-Cas immunity can also be updated by integrating new spacers from the same invading elements, a process called 'primed adaptation'. Only properly selected and integrated spacers are functional in the next steps of CRISPR immunity when their processed transcripts are used for RNA-guided target recognition and interference (target degradation). Capturing, trimming, and integrating new spacers in the correct orientation are universal steps of adaptation to all CRISPR-Cas systems, but some details are CRISPR-Cas type-specific and species-specific. In this review, we provide an overview of the mechanisms of CRISPR-Cas class 1 type I-E adaptation in Escherichia coli as a general model of adaptation processes (DNA capture and integration) that have been studied in detail.  We focus on the role of many host non-Cas proteins involved in adaptation, particularly on the role of homologous recombination. + Copyright 2023 The Author(s). + + + + Mitic + Damjan + D + + Sveuciliste u Zagrebu Bioloski odsjek, Zagreb, Croatia. + + + + Bolt + Edward L + EL + + University of Nottingham, Nottingham, United Kingdom. + + + + Ivancic-Bace + Ivana + I + + Sveuciliste u Zagrebu Bioloski odsjek, Zagreb, Croatia. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Biosci Rep + 8102797 + 0144-8463 + + IM + + CRISPR-Cas + Cas1-Cas2 + E. coli + RecBCD + adaptation + +
+ + + + 2023 + 02 + 21 + + + 2022 + 05 + 27 + + + 2023 + 02 + 17 + + + 2023 + 2 + 22 + 13 + 48 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809461 + 232582 + 10.1042/BSR20221198 + + +
+ + + 36809464 + + 2023 + 02 + 22 + +
+ + 1860-8965 + + + 2023 + Feb + 21 + + + Forensic toxicology + Forensic Toxicol + + Identification of LSD analogs, 1cP-AL-LAD, 1cP-MIPLA, 1V-LSD and LSZ in sheet products. + 10.1007/s11419-023-00661-1 + + Many analogs of lysergic acid diethylamide (LSD) have recently appeared as designer drugs around the world. These compounds are mainly distributed as sheet products. In this study, we identified three more newly distributed LSD analogs from paper sheet products. + The structures of the compounds were determined by gas chromatography-mass spectrometry (GC-MS), liquid chromatography-photodiode array-mass spectrometry (LC-PDA-MS), liquid chromatography with hybrid quadrupole time-of-flight mass spectrometry (LC-Q-TOF-MS) and nuclear magnetic resonance (NMR) spectroscopy. + From the NMR analysis, the compounds in the four products were identified as 4-(cyclopropanecarbonyl)-N,N-diethyl-7-(prop-2-en-1-yl)-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide (1cP-AL-LAD), 4-(cyclopropanecarbonyl)-N-methyl-N-isopropyl-7-methyl-4,6,6a,7,8,9-hexahydroindolo-[4,3-fg]quinoline-9-carboxamide (1cP-MIPLA), N,N-diethyl-7-methyl-4-pentanoyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide (1V-LSD) and (2'S,4'S)-lysergic acid 2,4-dimethylazetidide (LSZ). In comparison with the structure of LSD, 1cP-AL-LAD was converted at the positions at N1 and N6, and 1cP-MIPLA was converted at the positions at N1 and N18. The metabolic pathways and biological activities of 1cP-AL-LAD and 1cP-MIPLA have not been reported. + This is the first report showing that LSD analogs that were converted at multiple positions have been detected in sheet products in Japan. There are concerns about the future distribution of sheet drug products containing new LSD analogs. Therefore, the continuous monitoring for newly detected compounds in sheet products is important. + © 2023. The Author(s). + + + + Tanaka + Rie + R + + Division of Pharmacognosy, Phytochemistry and Narcotics, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-Ku, Kawasaki, Kanagawa, 210-9501, Japan. r-tanaka@nihs.go.jp. + + + + Kawamura + Maiko + M + + Division of Pharmacognosy, Phytochemistry and Narcotics, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-Ku, Kawasaki, Kanagawa, 210-9501, Japan. + + + + Mizutani + Sakumi + S + + Division of Pharmacognosy, Phytochemistry and Narcotics, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-Ku, Kawasaki, Kanagawa, 210-9501, Japan. + + + + Kikura-Hanajiri + Ruri + R + + Division of Pharmacognosy, Phytochemistry and Narcotics, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-Ku, Kawasaki, Kanagawa, 210-9501, Japan. + + + + eng + + + 19KC1002 + Ministry of Health, Labour and Welfare + + + + 22KC1004 + Ministry of Health, Labour and Welfare + + + + 21KC1002 + Ministry of Health, Labour and Welfare + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Japan + Forensic Toxicol + 101315563 + 1860-8965 + + IM + + Blotter paper + LSD + Lysergamide + Lysergic acid diethylamide + New psychoactive substance (NPS) + +
+ + + + 2022 + 09 + 12 + + + 2023 + 01 + 30 + + + 2023 + 2 + 22 + 13 + 48 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809464 + 10.1007/s11419-023-00661-1 + 10.1007/s11419-023-00661-1 + + + + Stoll A, Hoffmann A (1943) Partialsynthese von Alkaloiden vom Typus des Ergobasins. (6. Mitteilung über Mutterkornalkaloide). Helv Chim Acta 26:944–965 + + 10.1002/hlca.19430260326 + + + + EMCDDA (2016) EMCDDA–Europol 2016 Annual Report on the implementation of Council Decision 2005/387/JHA. EMCDDA-Europol, Lisbon, July 2017 http://www.emcdda.europa.eu/system/files/publications/4724/TDAN17001ENN_PDFWEB.pdf . Accessed 11 May 2020. + + + EMCDDA (2017) EMCDDA–Europol 2017 Annual Report on the implementation of Council Decision 2005/387/JHA. EMCDDA-Europol, Lisbon, February 2018: http://www.emcdda.europa.eu/system/files/publications/9282/20183924_TDAN18001ENN_PDF . .pdf. Accessed 11 May 2020. + + + Brandt SD, Kavanagh PV, Westphal F, Stratford A, Elliott SP, Hoang K, Wallach J, Halberstadt AL (2016) Return of the lysergamides Part I: Analytical and behavioural characterization of 1-propionyl-d-lysergic acid diethylamide (1P-LSD). Drug Test Anal 8:891–902 + + 10.1002/dta.1884 + 26456305 + + + + Brandt SD, Kavanagh PV, Westphal F, Elliott SP, Wallach J, Colestock T, Burrow TE, Chapman SJ, Stratford A, Nichols DE, Halberstadt AL (2017) Return of the lysergamides. Part II: analytical and behavioural characterization of N6-allyl-6-norlysergic acid diethylamide (AL-LAD) and (2’S,4’S)-lysergic acid 2,4-dimethylazetidide (LSZ). Drug Test Anal 9:38–50 + + 10.1002/dta.1985 + 27265891 + + + + Brandt SD, Kavanagh PV, Westphal F, Elliott SP, Wallach J, Stratford A, Nichols DE, Halberstadth AL (2017) Return of the lysergamides. Part III: analytical characterization of N6-ethyl-6-norlysergic acid diethylamide (ETH-LAD) and 1-propionyl ETH-LAD (1P-ETH-LAD). Drug Test Anal 9:1641–1649 + + 10.1002/dta.2196 + 28342178 + 6230477 + + + + Brandt SD, Kavanagh PV, Westphal F, Stratford A, Odland AU, Klein AK, Dowling G, Dempster NM, Wallach J, Passie T, Halberstadt AL (2020) Return of the lysergamides. Part VI: Analytical and behavioural characterization of 1-cyclopropanoyl-d-lysergic acid diethylamide (1CP-LSD). Drug Test Anal 12:812–826 + + 10.1002/dta.2789 + 32180350 + 9191646 + + + + Brandt SD, Kavanagh PV, Westphal F, Stratford A, Elliott SP, Dowling G, Wallach J, Halberstadt AL (2019) Return of the lysergamides. Part V: analytical and behavioural characterization of 1-butanoyl-d-lysergic acid diethylamide (1B-LSD). Drug Test Anal 11:1122–1133 + + 10.1002/dta.2613 + 31083768 + 6899222 + + + + Tanaka R, Kawamura M, Hakamatsuka T, Kikura-Hanajiri R (2020) Identification and analysis of LSD derivatives in illegal products as paper sheet. Yakugaku Zasshi (in Japanese) 140:739–750 + + 10.1248/yakushi.19-00230 + + + + Tanaka R, Kawamura M, Hakamatsuka T, Kikura-Hanajiri R (2020) Identification of LSD derivatives, 1cP-LSD, MIPLA and 1B-LSD in illegal products as paper sheet. Yakugaku Zasshi (in Japanese) 140:1405–1413 + + 10.1248/yakushi.20-00124 + + + + Halberstadt AL, Chatha M, Klein AK, McCorvy JD, Meyer MR, Wagmann L, Stratford A, Brandt SD (2020) Pharmacological and biotransformation studies of 1-acyl-substituted derivatives of d-lysergic acid diethylamide (LSD). Neuropharmacology 172:107856 + + 10.1016/j.neuropharm.2019.107856 + 31756337 + + + + Brandt SD, Kavanagh PV, Westphal F, Pulver B, Morton K, Stratford A, Dowling G, Halberstadth AL (2022) Return of the lysergamides. Part VII: analytical and behavioural characterization of 1-valeroyl-D-lysergic acid diethylamide(1V-LSD). Drug Test Anal 14:733–740 + + 10.1002/dta.3205 + 34837347 + + + + Salamone SJ, Li Z, McNally AJ, Vitone S, Wu RS (1997) Epimerization studies of LSD using 1H nuclear magnetic resonance (NMR) spectroscopy. J Anal Toxicol 21:492–497 + + 10.1093/jat/21.6.492 + 9323531 + + + + Li Z, McNally AJ, Wang H, Salamone SJ (1998) Stability study of LSD under various storage conditions. J Anal Toxicol 22:520–525 + + 10.1093/jat/22.6.520 + 9788528 + + + + Brandt SD, Kavanagh PV, Westphal F, Pulver B, Schwelm HM, Whitelock K, Stratford A, Auwärter V, Halberstadth AL (2022) Analytical profile, in vitro metabolism and behavioral properties of the lysergamide 1P-AL-LAD. Drug Test Anal 14:1503–1518 + + 10.1002/dta.3281 + 35524430 + 9546273 + + + + Nichols DE, Frescas S, Marona-Lewicka D, Kurrasch-Orbaugh DM (2002) Lysergamides of isomeric 2,4-dimethylazetidines map the binding orientation of the diethylamide moiety in the potent hallucinogenic agent N, N-diethyllysergamide (LSD). J Med Chem 45:4344–4349 + + 10.1021/jm020153s + 12213075 + + + + +
+ + + 36809469 + + 2023 + 02 + 22 + +
+ + 2574-3805 + + 6 + 2 + + 2023 + Feb + 01 + + + JAMA network open + JAMA Netw Open + + Association of Neighborhood-Level Household Income With 21-Gene Recurrence Score and Survival Among Patients With Estrogen Receptor-Positive Breast Cancer. + + e230179 + + 10.1001/jamanetworkopen.2023.0179 + + While low income has been associated with a higher incidence of triple-negative breast cancer, its association with 21-gene recurrence score (RS) among patients with estrogen receptor (ER)-positive breast cancer remains unclear. + To evaluate the association of household income with RS and overall survival (OS) among patients with ER-positive breast cancer. + This cohort study used data from the National Cancer Database. Eligible participants included women diagnosed between 2010 and 2018 with ER-positive, pT1-3N0-1aM0 breast cancer who received surgery followed by adjuvant endocrine therapy with or without chemotherapy. Data analysis was performed from July 2022 to September 2022. + Low vs high neighborhood-level household income levels defined as below vs above the median household income of $50 353 based on each patient's zip code. + RS (a score ranged from 0 to 100 based on gene expression signatures indicating the risk of distant metastasis, with RS of 25 or below indicating non-high risk and RS above 25 indicating high risk) and OS. + Among 119 478 women (median [IQR] age, 60 [52-67] years; 4737 [4.0%] Asian and Pacific Islander, 9226 [7.7%] Black, 7245 [6.1%] Hispanic, 98 270 [82.2%] non-Hispanic White), 82 198 (68.8%) and 37 280 (31.2%) patients had high and low income, respectively. Logistic multivariable analysis (MVA) showed that, compared with high income, low income was associated with higher RS (adjusted odds ratio [aOR], 1.11; 95% CI, 1.06-1.16). Cox MVA showed that low income was also associated with worse OS (adjusted hazards ratio [aHR], 1.18; 95% CI, 1.11-1.25). Interaction term analysis showed a statistically significant interaction between income levels and RS (interaction P < .001). On subgroup analysis, significant findings were noted among those with RS below 26 (aHR, 1.21; 95% CI, 1.13-1.29), while there was no significant OS difference between income levels among others with RS of 26 or higher (aHR, 1.08; 95% CI, 0.96-1.22). + Our study suggested that low household income was independently associated with higher 21-gene recurrence scores and significantly worse survival outcomes among those with scores below 26, but not 26 or higher. Further studies are warranted to investigate the association between socioeconomic determinants of health and intrinsic tumor biology among patients with breast cancer. + + + + Ma + Sung Jun + SJ + + Department of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York. + + + + Gill + Jasmin + J + + University at Buffalo, The State University of New York, Buffalo. + + + + Waldman + Olivia + O + + Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo. + + + + Yendamuri + Keerti + K + + University at Buffalo, The State University of New York, Buffalo. + + + + Dunne-Jaffe + Cynthia + C + + Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo. + + + + Chatterjee + Udit + U + + Department of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York. + + + + Fekrmandi + Fatemeh + F + + Department of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York. + + + + Shekher + Rohil + R + + Department of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York. + + + + Iovoli + Austin + A + + Department of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York. + + + + Yao + Song + S + + Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, New York. + + + + Oladeru + Oluwadamilola T + OT + + Department of Radiation Oncology, University of Florida, Gainesville. + + + + Singh + Anurag K + AK + + Department of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York. + + + + eng + + Journal Article + + + 2023 + 02 + 01 + +
+ + United States + JAMA Netw Open + 101729235 + 2574-3805 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 49 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809469 + 2801652 + 10.1001/jamanetworkopen.2023.0179 + + +
+ + + 36809468 + + 2023 + 02 + 22 + +
+ + 2574-3805 + + 6 + 2 + + 2023 + Feb + 01 + + + JAMA network open + JAMA Netw Open + + Using Haplotype-Based Artificial Intelligence to Evaluate SARS-CoV-2 Novel Variants and Mutations. + + e230191 + + 10.1001/jamanetworkopen.2023.0191 + + Earlier detection of emerging novel SARS-COV-2 variants is important for public health surveillance of potential viral threats and for earlier prevention research. Artificial intelligence may facilitate early detection of SARS-CoV2 emerging novel variants based on variant-specific mutation haplotypes and, in turn, be associated with enhanced implementation of risk-stratified public health prevention strategies. + To develop a haplotype-based artificial intelligence (HAI) model for identifying novel variants, including mixture variants (MVs) of known variants and new variants with novel mutations. + This cross-sectional study used serially observed viral genomic sequences globally (prior to March 14, 2022) to train and validate the HAI model and used it to identify variants arising from a prospective set of viruses from March 15 to May 18, 2022. + Viral sequences, collection dates, and locations were subjected to statistical learning analysis to estimate variant-specific core mutations and haplotype frequencies, which were then used to construct an HAI model to identify novel variants. + Through training on more than 5 million viral sequences, an HAI model was built, and its identification performance was validated on an independent validation set of more than 5 million viruses. Its identification performance was assessed on a prospective set of 344 901 viruses. In addition to achieving an accuracy of 92.8% (95% CI within 0.1%), the HAI model identified 4 Omicron MVs (Omicron-Alpha, Omicron-Delta, Omicron-Epsilon, and Omicron-Zeta), 2 Delta MVs (Delta-Kappa and Delta-Zeta), and 1 Alpha-Epsilon MV, among which Omicron-Epsilon MVs were most frequent (609/657 MVs [92.7%]). Furthermore, the HAI model found that 1699 Omicron viruses had unidentifiable variants given that these variants acquired novel mutations. Lastly, 524 variant-unassigned and variant-unidentifiable viruses carried 16 novel mutations, 8 of which were increasing in prevalence percentages as of May 2022. + In this cross-sectional study, an HAI model found SARS-COV-2 viruses with MV or novel mutations in the global population, which may require closer examination and monitoring. These results suggest that HAI may complement phylogenic variant assignment, providing additional insights into emerging novel variants in the population. + + + + Zhao + Lue Ping + LP + + Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. + + + + Cohen + Seth + S + + Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. + + + Department of Medicine, University of Washington School of Medicine, Seattle. + + + + Zhao + Michael + M + + QuantFu Inc, Boston, Massachusetts. + + + + Madeleine + Margaret + M + + Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. + + + + Payne + Thomas H + TH + + Department of Medicine, University of Washington School of Medicine, Seattle. + + + + Lybrand + Terry P + TP + + Quintepa Computing LLC, Nashville, Tennessee. + + + Department of Chemistry, Vanderbilt University; Nashville, Tennessee. + + + + Geraghty + Daniel E + DE + + Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. + + + + Jerome + Keith R + KR + + Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. + + + Department of Medicine, University of Washington School of Medicine, Seattle. + + + + Corey + Lawrence + L + + Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. + + + Department of Medicine, University of Washington School of Medicine, Seattle. + + + + eng + + Journal Article + + + 2023 + 02 + 01 + +
+ + United States + JAMA Netw Open + 101729235 + 2574-3805 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 49 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809468 + 2801651 + 10.1001/jamanetworkopen.2023.0191 + + +
+ + + 36809470 + + 2023 + 02 + 22 + +
+ + 2574-3805 + + 6 + 2 + + 2023 + Feb + 01 + + + JAMA network open + JAMA Netw Open + + Measures of Brain Connectivity and Cognition by Sex in US Children. + + e230157 + + 10.1001/jamanetworkopen.2023.0157 + + The neurobiological underpinnings underlying sex differences in cognition during adolescence are largely unknown. + To examine sex differences in brain circuitry and their association with cognitive performance in US children. + This cross-sectional study analyzed behavioral and imaging data from 9- to 11-year-old children from the Adolescent Brain Cognitive Development (ABCD) study between August 2017 and November 2018. The ABCD study is an open-science, multisite study following up more than 11 800 youths into early adulthood for 10 years with annual laboratory-based assessments and biennial magnetic resonance imaging (MRI). The selection of ABCD study children for the current analysis was based on the availability of functional and structural MRI data sets in ABCD Brain Imaging Data Structure Community Collection format. Five hundred and sixty participants who had excessive level of head motion (>50% of time points with framewise displacement >0.5 mm) during resting-state functional MRI were excluded from the analyses. Data were analyzed between January and August 2022. + The main outcomes were the sex differences in (A) global functional connectivity density at rest and (B) mean water diffusivity (MD) and (C) the correlation of these metrics with total cognitive scores. + A total of 8961 children (4604 boys and 4357 girls; mean [SD] age, 9.92 [0.62] years) were included in this analysis. Girls had higher functional connectivity density in default mode network hubs than boys, predominantly in the posterior cingulate cortex (Cohen d = -0.36), and lower MD and transverse diffusivity, predominantly in the superior corticostriatal white matter bundle (Cohen d = 0.3). Age-corrected fluid and total composite scores were higher for girls than for boys (Cohen d = -0.08 [fluid] and -0.04 [total]; P = 2.7 × 10-5). Although total mean (SD) brain volume (1260 [104] mL in boys and 1160 [95] mL in girls; t = 50; Cohen d = 1.0; df = 8738) and the proportion of white matter (d = 0.4) were larger for boys than for girls, the proportion of gray matter was larger for girls than for boys (d = -0.3; P = 2.2 × 10-16). + The findings of this cross-sectional study on sex differences in brain connectivity and cognition are relevant to the future creation of brain developmental trajectory charts to monitor for deviations associated with impairments in cognition or behavior, including those due to psychiatric or neurological disorders. They could also serve as a framework for studies investigating the differential contribution of biological vs social or cultural factors in the neurodevelopmental trajectories of girls and boys. + + + + Tomasi + Dardo + D + + Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland. + + + + Volkow + Nora D + ND + + Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland. + + + National Institute on Drug Abuse, Bethesda, Maryland. + + + + eng + + Journal Article + + + 2023 + 02 + 01 + +
+ + United States + JAMA Netw Open + 101729235 + 2574-3805 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 49 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809470 + 2801653 + 10.1001/jamanetworkopen.2023.0157 + + +
+ + + 36809465 + + 2023 + 02 + 22 + +
+ + 2051-6355 + + + 2023 + Feb + 21 + + + Materials horizons + Mater Horiz + + Vertical 0.6 V sub-10 nm oxide-homojunction transistor gated by a silk fibroin/sodium alginate crosslinking hydrogel for pain-sensitization enhancement emulation. + 10.1039/d2mh01431a + + The sensory nervous system of humans mainly depends on continuous training and memory to improve the pain-perceptional abilities for the complex noxious information in the real world and make appropriate responses. Unfortunately, the solid-state device for emulating this pain recognition with ultralow voltage operation still remains to be a great challenge. Herein, a vertical transistor with an ultrashort channel of ∼9.6 nm and ultralow voltage of ∼0.6 V based on protonic silk fibroin/sodium alginate crosslinking hydrogel electrolyte is successfully demonstrated. Such a hydrogel electrolyte with high ionic conductivity allows the transistor to work in an ultralow voltage, while the vertical transistor structure makes it have an ultrashort channel. Pain perception, memory, and sensitization can be integrated into this vertical transistor. Furthermore, using the photogating effect of light stimulus, the device displays multi-state pain-sensitization enhancement abilities through Pavlovian training. Most importantly, the cortical reorganization that reveals a close relationship among the pain stimulus, memory, and sensitization is finally realized. Therefore, this device can provide a great opportunity for multi-dimensional pain assessment, which is of great significance for the new generation of bio-inspired intelligent electronics, such as bionic robots, and smart medical equipment. + + + + Su + Jingya + J + + Hunan Key Laboratory of Nanophotonics and Devices, Hunan Key Laboratory of Super Microstructure and Ultrafast Process, School of Physics and Electronics, Central South University, Changsha, Hunan 410083, China. jiangjie@csu.edu.cn. + + + + Li + Yanran + Y + + Hunan Key Laboratory of Nanophotonics and Devices, Hunan Key Laboratory of Super Microstructure and Ultrafast Process, School of Physics and Electronics, Central South University, Changsha, Hunan 410083, China. jiangjie@csu.edu.cn. + + + + Xie + Dingdong + D + http://orcid.org/0000-0002-6179-8904 + + Hunan Key Laboratory of Nanophotonics and Devices, Hunan Key Laboratory of Super Microstructure and Ultrafast Process, School of Physics and Electronics, Central South University, Changsha, Hunan 410083, China. jiangjie@csu.edu.cn. + + + + Jiang + Jie + J + http://orcid.org/0000-0002-9834-6880 + + Hunan Key Laboratory of Nanophotonics and Devices, Hunan Key Laboratory of Super Microstructure and Ultrafast Process, School of Physics and Electronics, Central South University, Changsha, Hunan 410083, China. jiangjie@csu.edu.cn. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Mater Horiz + 101623537 + 2051-6347 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 48 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809465 + 10.1039/d2mh01431a + + +
+ + + 36809471 + + 2023 + 02 + 22 + +
+ + 2574-3805 + + 6 + 2 + + 2023 + Feb + 01 + + + JAMA network open + JAMA Netw Open + + Rates of Spontaneous Abortion in Israel Before and During the COVID-19 Pandemic. + + e230233 + + 10.1001/jamanetworkopen.2023.0233 + + + Travis-Lumer + Yael + Y + + Faculty of Data and Decision Sciences, Israel Institute of Technology, Haifa, Israel. + + + + Goldberg + Yair + Y + + Faculty of Data and Decision Sciences, Israel Institute of Technology, Haifa, Israel. + + + + Kodesh + Arad + A + + Mental Health Department, Meuhedet Health Services, Tel Aviv, Israel. + + + + Reichenberg + Abraham + A + + Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York. + + + + Sandin + Sven + S + + Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York. + + + + Frangou + Sophia + S + + Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada. + + + + Levine + Stephen Z + SZ + + School of Public Health, University of Haifa, Haifa, Israel. + + + + eng + + Journal Article + + + 2023 + 02 + 01 + +
+ + United States + JAMA Netw Open + 101729235 + 2574-3805 + + IM + + This cross-sectional study uses electronic health record data to compare monthly incidence rates of spontaneous abortion in Israel before and during the COVID-19 pandemic. + +
+ + + + 2023 + 2 + 22 + 13 + 49 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809471 + 2801654 + 10.1001/jamanetworkopen.2023.0233 + + +
+ + + 36809474 + + 2023 + 02 + 22 + +
+ + 1463-9084 + + + 2023 + Feb + 21 + + + Physical chemistry chemical physics : PCCP + Phys Chem Chem Phys + + Free energy change in the complete transport of all water molecules through a carbon nanotube. + 10.1039/d2cp04666k + + In this work, we investigated the free energy barrier for transporting water molecules from one place to another. To properly address this issue, we considered a simple model system in which two separate compartments were connected via a subnanometer channel; all water molecules were initially in one compartment, and the other compartment was empty. Using umbrella sampling in molecular dynamics simulations, we calculated the free energy change for transporting all water molecules to the initially empty compartment. The free energy profile clearly indicated the presence of a free energy barrier, and the magnitude and shape of the barrier were dependent on the number of water molecules to be transported. To better understand the nature of the profile, we performed additional analyses on the potential energy of the system and hydrogen bonding between water molecules. Our study sheds light on a method for calculating the free energy of a transport system as well as the fundamental aspects of water transport. + + + + Kwon + Youngjun + Y + + Department of Chemistry, Hankuk University of Foreign Studies, Yongin 17035, Republic of Korea. ceun@hufs.ac.kr. + + + + Eun + Changsun + C + http://orcid.org/0000-0002-7068-9144 + + Department of Chemistry, Hankuk University of Foreign Studies, Yongin 17035, Republic of Korea. ceun@hufs.ac.kr. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Phys Chem Chem Phys + 100888160 + 1463-9076 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 49 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809474 + 10.1039/d2cp04666k + + +
+ + + 36809472 + + 2023 + 02 + 22 + +
+ + 2574-3805 + + 6 + 2 + + 2023 + Feb + 01 + + + JAMA network open + JAMA Netw Open + + Accessibility of State and Territory Public Health Department Website Information on COVID-19 Outpatient Treatments in the US. + + e230186 + + 10.1001/jamanetworkopen.2023.0186 + + + Eckert + Cody + C + + University of Rochester Medical Center, Rochester, New York. + + + + Sanders + Mechelle + M + + University of Rochester Medical Center, Rochester, New York. + + + + Bharadwaj + Rhea + R + + University of Rochester Medical Center, Rochester, New York. + + + + Fiscella + Kevin A + KA + + University of Rochester Medical Center, Rochester, New York. + + + + eng + + Journal Article + + + 2023 + 02 + 01 + +
+ + United States + JAMA Netw Open + 101729235 + 2574-3805 + + IM + + This cross-sectional study assesses the reading level and accessibility of information on COVID-19 treatments posted on US public health websites for states, territories, and Washington, DC. + +
+ + + + 2023 + 2 + 22 + 13 + 49 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809472 + 2801655 + 10.1001/jamanetworkopen.2023.0186 + + +
+ + + 36809466 + + 2023 + 02 + 22 + +
+ + 1573-7438 + + 55 + 2 + + 2023 + Feb + 21 + + + Tropical animal health and production + Trop Anim Health Prod + + Dwarf and tall elephant grass silages: intake, nutrient digestibility, nitrogen balance, ruminal fermentation, and ingestive behavior in sheep. + + 93 + + 10.1007/s11250-023-03502-w + + The objective of this study was to evaluate the exclusive supply of dwarf or tall elephant grass silages, harvested at 60 days of growth, without wilting or the use of additives, on intake, apparent digestibility, nitrogen balance, rumen parameters, and ingestive behavior of sheep. Eight castrated male crossbred sheep (57.6 ± 5.25 kg body weight), fistulated in the rumen, were distributed in two 4 × 4 Latin squares with four treatments and eight animals per treatment and four periods. The treatments consisted of four elephant grass genotype silages (Mott, Taiwan A-146 2.37, IRI-381, or Elephant B). There was no effect of silages (P > 0.05) on dry matter, neutral detergent fiber, and total digestible nutrient intake. The dwarf-sized elephant grass silages provided higher crude protein intake (P = 0.047) and N intake (P = 0.047), while the IRI-381 genotype silage provided higher non-fibrous carbohydrate intake compared to Mott (P = 0.042), without differing from Taiwan A-146 2.37 and Elephant B silages. There were no differences (P > 0.05) among the digestibility coefficients of the evaluated silages. It was observed that silages produced with Mott and IRI-381 genotypes caused a slight decrease in ruminal pH (P = 0.013), and the propionic acid concentration was higher in the rumen fluid of the animals fed with Mott silage (P = 0.021). Therefore, dwarf or tall elephant grass silages, produced with cut genotypes at 60 days of growth and without the use of additives or wilting process, can be used in sheep feeding. + © 2023. The Author(s), under exclusive licence to Springer Nature B.V. + + + + Soares + Luciana Felizardo Pereira + LFP + http://orcid.org/0000-0003-3504-3783 + + Department of Animal Science, Federal Rural University of Pernambuco, Dom Manuel de Medeiros Street, S/N, Dois Irmãos, Recife, PE, 52171-900, Brazil. + + + + Guim + Adriana + A + http://orcid.org/0000-0002-6589-9104 + + Department of Animal Science, Federal Rural University of Pernambuco, Dom Manuel de Medeiros Street, S/N, Dois Irmãos, Recife, PE, 52171-900, Brazil. + + + + de Mello + Alexandre Carneiro Leão + ACL + http://orcid.org/0000-0002-4721-9021 + + Department of Animal Science, Federal Rural University of Pernambuco, Dom Manuel de Medeiros Street, S/N, Dois Irmãos, Recife, PE, 52171-900, Brazil. + + + + de Andrade Ferreira + Marcelo + M + http://orcid.org/0000-0002-9155-4388 + + Department of Animal Science, Federal Rural University of Pernambuco, Dom Manuel de Medeiros Street, S/N, Dois Irmãos, Recife, PE, 52171-900, Brazil. + + + + de Carvalho + Francisco Fernando Ramos + FFR + http://orcid.org/0000-0001-9211-0263 + + Department of Animal Science, Federal Rural University of Pernambuco, Dom Manuel de Medeiros Street, S/N, Dois Irmãos, Recife, PE, 52171-900, Brazil. + + + + de Lima Silva + Janaina + J + http://orcid.org/0000-0001-8067-7588 + + Multidisciplinary Center of Barra, Federal University of Western Bahia, Av. 23 de Agosto, S/N, Assunção, Barra, BA, 47100-000, Brazil. + + + + de Melo Vasco + Ana Caroline Cerqueira + ACC + http://orcid.org/0000-0002-4593-5585 + + Department of Animal Sciences, University of Florida, Gainesville, FL, USA. + + + + da Silva + Tomás Guilherme Pereira + TGP + http://orcid.org/0000-0002-6115-5474 + + Department of Animal Science, Federal Rural University of Pernambuco, Dom Manuel de Medeiros Street, S/N, Dois Irmãos, Recife, PE, 52171-900, Brazil. tomasguilherme91@gmail.com. + + + + Neves + Maria Luciana Menezes Wanderley + MLMW + http://orcid.org/0000-0003-0077-4041 + + Department of Animal Science, Federal Rural University of Pernambuco, Dom Manuel de Medeiros Street, S/N, Dois Irmãos, Recife, PE, 52171-900, Brazil. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Trop Anim Health Prod + 1277355 + 0049-4747 + + IM + + Genotype size + Grass silage + Pennisetum purpureum + Quality + Small ruminants + +
+ + + + 2022 + 08 + 12 + + + 2023 + 02 + 11 + + + 2023 + 2 + 22 + 13 + 48 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809466 + 10.1007/s11250-023-03502-w + 10.1007/s11250-023-03502-w + + + + Allen, M.S., 1997. Relationship between fermentation acid production in the rumen and the requirement for physically effective fiber. Journal of Dairy Science, 80, 1447-1462. + + 9241607 + 10.3168/jds.S0022-0302(97)76074-0 + + + + Alvares, C.A., Stape, J.L., Sentelhas, P.C., de Moraes Gonçalves, J.L. and Sparovek, G., 2013. Köppen's climate classification map for Brazil. Meteorologische Zeitschrift, 22, 711-728. + + 10.1127/0941-2948/2013/0507 + + + + Alves, E.M., Pedreira, M.S., Oliveira, C.A.S., Ferreira, D.N., Moreira, B.S. and Freire, L.D.R., 2010. Importância da sincronização do complexo proteína/energia na alimentação de ruminantes. PUBVET, 4, 1-15. + + + Alves, A.R., Pascoal, L.A.F., Cambuí, G.B., Trajano, J.S., Silva, C.M. and Gois, G.C., 2016. 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+ + + 36809478 + + 2023 + 02 + 22 + +
+ + 1477-9234 + + + 2023 + Feb + 21 + + + Dalton transactions (Cambridge, England : 2003) + Dalton Trans + + Synthesis, structural characterization, reactivity and catalytic activity of mixed halo/triflate ArI(OTf)(X) species. + 10.1039/d3dt00275f + + Both mixed λ3-iodoarenes and λ3-iodoarenes possessing -OTf ligands are coveted for their enhanced reactivities. Here we describe the synthesis, reactivity, and comprehensive characterisation of two new ArI(OTf)(X) species, a class of compound that were previously only invoked as reactive intermediates where X = Cl, F and their divergent reactivity with aryl substrates. A new catalytic system for electrophilic chlorination of deactivated arenes using Cl2 as the chlorine source and ArI/HOTf as the catalyst is also described. + + + + Sharp-Bucknall + Lachlan + L + http://orcid.org/0000-0002-4728-7964 + + Department of Chemistry, La Trobe University, Melbourne, Victoria, Australia. j.dutton@latrobe.edu.au. + + + + Sceney + Marcus + M + + Department of Chemistry, La Trobe University, Melbourne, Victoria, Australia. j.dutton@latrobe.edu.au. + + + + White + Keith F + KF + http://orcid.org/0000-0003-2800-1104 + + Department of Chemistry, La Trobe University, Melbourne, Victoria, Australia. j.dutton@latrobe.edu.au. + + + + Dutton + Jason L + JL + http://orcid.org/0000-0002-0361-4441 + + Department of Chemistry, La Trobe University, Melbourne, Victoria, Australia. j.dutton@latrobe.edu.au. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Dalton Trans + 101176026 + 1477-9226 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 49 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809478 + 10.1039/d3dt00275f + + +
+ + + 36809467 + + 2023 + 02 + 22 + +
+ + 1559-131X + + 40 + 3 + + 2023 + Feb + 21 + + + Medical oncology (Northwood, London, England) + Med Oncol + + Identification of potential tumor antigens and immune subtypes for lung adenocarcinoma. + + 100 + + 10.1007/s12032-023-01973-3 + + In lung adenocarcinoma (LUAD), tumor antigens and immune phenotypes are important for cancer immunotherapy. This study aims to identify potential tumor antigens and immune subtypes for LUAD. In this study, the gene expression profiles and related clinical data of LUAD patients were collected from the TCGA and the GEO database. Then, we first identified four genes with copy number variation and mutation related to the survival of LUAD patients, in which FAM117A, INPP5J, and SLC25A42 were screened as potential tumor antigens. The expressions of these genes were significantly correlated with the infiltration of B cells CD4+ T cells and dendritic cells using TIMER and CIBERSORT algorithms. LUAD patients were divided into three immune clusters: C1(immune-desert), C2(immune-active), and C3(inflamed) using the Non-negative matrix factorization algorithm by using survival-related immune genes. The C2 cluster showed favorable overall survival compared to C1 and C3 clusters in both TCGA and two GEO LUAD cohorts. Different immune cell infiltration patterns, immune-associated molecular characteristics, and drug sensitivity were found among the three clusters. Moreover, different positions in the immune landscape map exhibited different prognostic characteristics using dimensionality reduction, providing further evidence of the immune clusters. The Weighted Gene Co-Expression Network Analysis was used to identify the co-expression modules of these immune genes. the three subtypes were significantly positively correlated with the turquoise module gene list, indicating a good prognosis with high scores. We hope that the identified tumor antigens and immune subtypes can be used for immunotherapy and prognosis in LUAD patients. + © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. + + + + Bai + Maoshu + M + http://orcid.org/0000-0003-4546-8849 + + Department of Oncology, Dazhou Integrated Traditional Chinese Medicine and Western Medicine Hospital, Dazhou, Sichuan, China. bmaoshu@aliyun.com. + + + + Liu + Xin + X + + Molecular Diagnosis Center, The Third Affiliated Hospital of Kunming Medical University, Tumor Hospital of Yunnan Province, Kunming, Yunnan, China. liuxinkm@126.com. + + + + Wang + Lingling + L + + Department of Oncology, Dazhou Integrated Traditional Chinese Medicine and Western Medicine Hospital, Dazhou, Sichuan, China. + + + + eng + + + 2021MS547 + Sichuan Provincial Administration of Traditional Chinese Medicine + + + + 22YYJC0014 + Dazhou Science and Technology Bureau + + + + 2017NS201 + Yunnan provincial health science and technology program + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Med Oncol + 9435512 + 1357-0560 + + IM + + Immune subtypes + Lung adenocarcinoma + Prognosis + Tumor antigens + Unsupervised clustering analysis + +
+ + + + 2022 + 12 + 30 + + + 2023 + 02 + 05 + + + 2023 + 2 + 22 + 13 + 49 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809467 + 10.1007/s12032-023-01973-3 + 10.1007/s12032-023-01973-3 + + + + Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65:87–108. + + 10.3322/caac.21262 + 25651787 + + + + Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209–49. + + 10.3322/caac.21660 + 33538338 + + + + Sun S, Guo W, Wang Z, Wang X, Zhang G, Zhang H, et al. Development and validation of an immune-related prognostic signature in lung adenocarcinoma. Cancer Med. 2020;9:5960–75. + + 10.1002/cam4.3240 + 32592319 + 7433810 + + + + Wakelee HA, Chang ET, Gomez SL, Keegan TH, Feskanich D, Clarke CA, et al. 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Genetic defects of the IRF1-mediated major histocompatibility complex class I antigen presentation pathway occur prevalently in the JAK2 gene in non-small cell lung cancer. Oncotarget. 2017;8:60975–86. + + 10.18632/oncotarget.17689 + 28977839 + 5617399 + + + + Liu F, Wu H. CC chemokine receptors in lung adenocarcinoma: the inflammation-related prognostic biomarkers and immunotherapeutic targets. J Inflamm Res. 2021;14:267–85. + + 10.2147/JIR.S278395 + 33574689 + 7872903 + + + + Wu C, Li X, Zhang D, Xu B, Hu W, Zheng X, et al. IL-1beta-mediated up-regulation of WT1D via miR-144-3p and their synergistic effect with NF-kappaB/COX-2/HIF-1alpha pathway on cell proliferation in LUAD. Cell Physiol Biochem. 2018;48:2493–502. + + 10.1159/000492687 + 30121641 + + + + Wang SS, Liu W, Ly D, Xu H, Qu L, Zhang L. Tumor-infiltrating B cells: their role and application in anti-tumor immunity in lung cancer. Cell Mol Immunol. 2019;16:6–18. + + 10.1038/s41423-018-0027-x + 29628498 + + + + Tan Q, Duan L, Huang Q, Chen W, Yang Z, Chen J, et al. Interleukin-1beta promotes lung adenocarcinoma growth and invasion through promoting glycolysis via p38 pathway. J Inflamm Res. 2021;14:6491–509. + + 10.2147/JIR.S319433 + 34880649 + 8648110 + + + + +
+ + + 36809476 + + 2023 + 02 + 22 + +
+ + 1758-5368 + + + 2023 + Feb + 21 + + + The journals of gerontology. Series B, Psychological sciences and social sciences + J Gerontol B Psychol Sci Soc Sci + + Kinless Older Adults with Dementia: Qualitative Analysis of Data from the Adult Changes in Thought (ACT) Study. + gbad030 + 10.1093/geronb/gbad030 + + To examine the circumstances and needs of older adults who were "kinless," defined as having no living spouse or children, when they developed dementia. + We conducted a secondary analysis of information from the Adult Changes in Thought (ACT) Study. Among 848 participants diagnosed with dementia between 1992 and 2016, we identified 64 who had no living spouse or child at dementia onset. We then conducted a qualitative analysis of administrative documents pertaining to these participants: handwritten comments recorded after each study visit, and medical history documents containing clinical chart notes from participants' medical records. + In this community dwelling cohort of older adults diagnosed with dementia, 8.4% were kinless at dementia onset. Participants in this sample had an average age of 87 years old, half lived alone, and one-third lived with unrelated persons. Through inductive content analysis we identified four themes that describe their circumstances and needs: 1) life trajectories, 2) caregiving resources, 3) care needs and gaps, and 4) turning points in caregiving arrangements. + Our qualitative analysis reveals that the life trajectories that led members of the analytic cohort to be kinless at dementia onset were quite varied. This research highlights the importance of non-family caregivers, and participants' own roles as caregivers. Our findings suggest that providers and health systems may need to work with other parties to directly provide dementia caregiving support rather than rely on family, and address factors such as neighborhood affordability that particularly affect older adults who have limited family support. + © The Author(s) 2023. Published by Oxford University Press on behalf of The Gerontological Society of America. + + + + Taylor + Janelle S + JS + 0000-0001-8162-5106 + + Department of Anthropology, University of Toronto. + + + + Figueroa Gray + Marlaine S + MS + + Kaiser Permanente Washington Health Research Institute. + + + + Mar + Corinne M + CM + + International Clinical Research Center, Department of Global Health, University of Washington. + + + + Crane + Paul K + PK + + Department of Medicine, University of Washington. + + + + Kariya + Hitomi + H + + Department of Health Systems and Population Health, University of Washington. + + + + Freitag + Callie + C + + Evans School of Public Policy, University of Washington. + + + + Taneja + Priyanka + P + + Pacific Northwest University of Health Sciences. + + + + Ramaprasan + Arvind + A + + Kaiser Permanente Washington Health Research Institute. + + + + Shell Duncan + Bettina + B + + Department of Anthropology, University of Washington. + + + + O'Hare + Ann M + AM + + Division of Nephrology, University of Washington. + + + + Berridge + Clara + C + 0000-0002-4218-9556 + + School of Social Work, University of Washington. + + + + Vig + Elizabeth K + EK + + Department of Medicine, University of Washington. + + + Geriatrics and Extended Care, VA Puget Sound Health Care System. + + + + Wheeler + Stephanie G B + SGB + + Department of Medicine, University of Washington. + + + + Thakral + Manu + M + 0000-0001-5503-1363 + + Manning College of Nursing and Health Sciences, University of Massachusetts Boston. + + + + Hawkes + Rene J + RJ + + Kaiser Permanente Washington Health Research Institute. + + + + Larson + Eric B + EB + + Kaiser Permanente Washington Health Research Institute. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + J Gerontol B Psychol Sci Soc Sci + 9508483 + 1079-5014 + + IM + + caregiving + dementia + family support + kinless + medical records + qualitative research + +
+ + + + 2022 + 07 + 27 + + + 2023 + 2 + 22 + 13 + 49 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809476 + 7049940 + 10.1093/geronb/gbad030 + + +
+ + + 36809479 + + 2023 + 02 + 22 + +
+ + 1758-4469 + + + 2023 + Feb + 21 + + + Tree physiology + Tree Physiol + + Populus root salicinoid phenolic glycosides are not mobilized to support metabolism and regrowth under carbon limited conditions. + tpad020 + 10.1093/treephys/tpad020 + + Remobilization of carbon storage compounds in trees is crucial for the resilience to disturbances, stress, and the requirements of their perennial lifestyle, all of which can impact photosynthetic carbon gain. Trees contain abundant non-structural carbohydrates (NSC) in the form of starch and sugars for long term carbon storage, yet questions remain about the ability of trees to remobilize non-conventional carbon compounds under stress. Aspens, like other members of the genus Populus, have abundant specialized metabolites called salicinoid phenolic glycosides, which contain a core glucose moiety. In this study, we hypothesized that the glucose-containing salicinoids could be remobilized as an additional carbon source during severe carbon limitation. We made use of genetically modified hybrid aspen (Populus tremula x P. alba) with minimal salicinoid content and compared these to control plants with high salicinoid content during resprouting (suckering) in dark (carbon limited) conditions. As salicinoids are abundant anti-herbivore compounds, identification of such a secondary function for salicinoids may provide insight to the evolutionary pressures that drive their accumulation. Our results show that salicinoid biosynthesis is maintained during carbon limitation and suggests that salicinoids are not remobilized as a carbon source for regenerating shoot tissue. However, we found that salicinoid-producing aspens had reduced resprouting capacity per available root biomass when compared to salicinoid-deficient aspens. Therefore, our work shows that the constitutive salicinoid production in aspens can reduce the capacity for resprouting and survival in carbon limited conditions. + © The Author(s) 2023. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. + + + + Hillabrand + R M + RM + 0000-0002-3166-4104 + + Department of Renewable Resources, University of Alberta, 442 ESB, Edmonton, Alberta, T6G 2E3, Canada. + + + + Gordon + H + H + + Centre for Forest Biology & Department of Biology, University of Victoria, 3800 Finnerty Road, V8P 5C2, Victoria, British Columbia, Canada. + + + + Hynes + B + B + + Department of Renewable Resources, University of Alberta, 442 ESB, Edmonton, Alberta, T6G 2E3, Canada. + + + + Constabel + C P + CP + 0000-0002-7627-7597 + + Centre for Forest Biology & Department of Biology, University of Victoria, 3800 Finnerty Road, V8P 5C2, Victoria, British Columbia, Canada. + + + + Landhäusser + S M + SM + + Department of Renewable Resources, University of Alberta, 442 ESB, Edmonton, Alberta, T6G 2E3, Canada. + + + + eng + + + RGPIN-2020-06646 + Natural Sciences and Engineering Research Council of Canada + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Canada + Tree Physiol + 100955338 + 0829-318X + + IM + + Aspen + carbohydrates + metabolism + poplar + roots + salicinoids + +
+ + + + 2022 + 08 + 17 + + + 2023 + 02 + 03 + + + 2023 + 2 + 22 + 13 + 49 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809479 + 7049616 + 10.1093/treephys/tpad020 + + +
+ + + 36809481 + + 2023 + 02 + 22 + +
+ + 2731-7013 + + + 2023 + Feb + 21 + + + Dermatologie (Heidelberg, Germany) + Dermatologie (Heidelb) + + [(Not) a visual diagnosis]. + 10.1007/s00105-023-05119-4 + + + Wolf + Nora + N + + Praxis Dr. med. Durani, Grüne Meile 56, 69115, Heidelberg, Deutschland. nwolf@outlook.de. + + + + Toberer + Ferdinand + F + + Hautklinik, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 440, 69120, Heidelberg, Deutschland. + + + + Hartschuh + Wolfgang + W + + Praxis Dr. med. Durani, Grüne Meile 56, 69115, Heidelberg, Deutschland. + + + Hautklinik, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 440, 69120, Heidelberg, Deutschland. + + + + ger + + Journal Article + + (K)eine Blickdiagnose. + + 2023 + 02 + 21 + +
+ + Germany + Dermatologie (Heidelb) + 9918384885206676 + 2731-7005 + + IM +
+ + + + 2023 + 01 + 26 + + + 2023 + 2 + 22 + 13 + 49 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809481 + 10.1007/s00105-023-05119-4 + 10.1007/s00105-023-05119-4 + + + Literatur + + Serrano P, Lallas A, Del Pozo LJ, Karaarslan I, Medina C, Thomas L, Landi C, Argenziano G, Zaballos P (2016) Dermoscopy of nodular hidradenoma, a great masquerader: a morphological study of 28 cases. Dermatology 232(1):78–82. https://doi.org/10.1159/000441218 + + 10.1159/000441218 + 26606241 + + + + Bijou W, Laababsi R, Oukessou Y, Rouadi S, Abada R, Roubal M, Mahtar M (2020) An unusual presentation of a nodular hidradenoma: a case report and review of the literature. Ann Med Surg 61:61–63. https://doi.org/10.1016/j.amsu.2020.11.050 + + 10.1016/j.amsu.2020.11.050 + + + + Kempf W, Hantschke M, Kutzner H (2020) Adnextumoren. In: Kempf W, Hantschke M, Kutzner H, Burgdorf W (Hrsg) Dermatopathologie, 4. Aufl. Springer, Berlin, Heidelberg, S 258–259 + + 10.1007/978-3-662-59240-3 + + + + Shetty A, Gnanadev P, Gaffoor N, Murali N (2023) Nodular hidradenoma of the lower limb impersonating as sebaceous cyst in a young female. J Health Allied Sci 13(01):137–140. https://doi.org/10.1055/s-0042-1746426 + + 10.1055/s-0042-1746426 + + + + Nazarian RM, Kapur P, Rakheja D, Piris A, Duncan LM, Mihm MC Jr, Hoang MP (2009) Atypical and malignant hidradenomas: a histological and immunohistochemical study. Mod Pathol 22(4):600–610. https://doi.org/10.1038/modpathol.2009.18 + + 10.1038/modpathol.2009.18 + 19252473 + + + + +
+ + + 36809473 + + 2023 + 02 + 22 + +
+ + 1537-6591 + + + 2023 + Feb + 21 + + + Clinical infectious diseases : an official publication of the Infectious Diseases Society of America + Clin Infect Dis + + COVID-19 Convalescent Plasma Outpatient Therapy to Prevent Outpatient Hospitalization: A Meta-analysis of Individual Participant Data From Five Randomized Trials. + ciad088 + 10.1093/cid/ciad088 + + Outpatient monoclonal antibodies are no longer effective and antiviral treatments for COVID-19 disease remain largely unavailable in many countries worldwide. Although treatment with COVID-19 convalescent plasma is promising, clinical trials among outpatients have shown mixed results. + We conducted an individual participant data meta-analysis from outpatient trials to assess the overall risk reduction for all-cause hospitalizations by day 28 in transfused participants. Relevant trials were identified by searching MEDLINE, Embase, MedRxiv, World Health Organization, Cochrane Library, and Web of Science from January 2020 to September 2022. + Five included studies from four countries enrolled and transfused 2,620 adult patients. Comorbidities were present in 1,795 (69%). The virus neutralizing antibody dilutional titer levels ranged from 8 to 14,580 in diverse assays. 160 (12.2%) of 1315 control patients were hospitalized, versus 111 (8.5%) of 1305 COVID-19 convalescent plasma treated patients, yielding a 3.7% (95%CI: 1.3%-6.0%; p=.001) absolute risk reduction and 30.1% relative risk reduction for all-cause hospitalization. The hospitalization reduction was greatest in those with both early transfusion and high titer with a 7.6% absolute risk reduction (95%CI: 4.0%-11.1%; p=.0001) accompanied by at 51.4% relative risk reduction. No significant reduction in hospitalization was seen with treatment > 5 days after symptom onset or in those receiving COVID-19 convalescent plasma with antibody titers below the median titer. + Among outpatients with COVID-19, treatment with COVID-19 convalescent plasma reduced the rate of all-cause hospitalization and may be most effective when given within 5 days of symptom onset and when antibody titer is higher. + © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. + + + + Levine + Adam C + AC + + Department of Emergency Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA. + + + + Fukuta + Yuriko + Y + + Department of Medicine - Infectious Disease, Baylor College of Medicine, Houston, Texas, USA. + + + + Huaman + Moises A + MA + + Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. + + + + Ou + Jiangda + J + + Division of Brain Injury Outcomes, Department of Neurology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA. + + + + Meisenberg + Barry R + BR + + Department of Hematology - Oncology, Anne Arundel Medical Center, Annapolis, Maryland, USA. + + + + Patel + Bela + B + + Division of Critical Care Medicine, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, USA. + + + + Paxton + James H + JH + + Department of Emergency Medicine, Wayne State University School of Medicine, Detroit, Michigan, USA. + + + + Hanley + Daniel F + DF + + Division of Brain Injury Outcomes, Department of Neurology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA. + + + + Rijnders + Bart Ja + BJ + + Department of Internal Medicine, Section of Infectious Diseases and department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. + + + + Gharbharan + Arvind + A + + Department of Internal Medicine, Section of Infectious Diseases and department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. + + + + Rokx + Casper + C + + Department of Internal Medicine, Section of Infectious Diseases and department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. + + + + Zwaginga + Jaap Jan + JJ + + Department of Haematology, Leiden University Medical Centre, Leiden, The Netherlands and; CCTR, Sanquin Blood Supply, Amsterdam, The Netherlands. + + + + Alemany + Andrea + A + + Fight Infectious Diseases Foundation, Badalona, Spain; Infectious Diseases Department, Hospital Universitari Germans Trias i Pujol, Badalona, Spain. + + + + Mitjà + Oriol + O + + Fight Infectious Diseases Foundation, Badalona, Spain; Infectious Diseases Department, Hospital Universitari Germans Trias i Pujol, Badalona, Spain. + + + Lihir Medical Centre, International SOS, Lihir Island, Papua New Guinea. + + + + Ouchi + Dan + D + + Fight Infectious Diseases Foundation, Badalona, Spain; Infectious Diseases Department, Hospital Universitari Germans Trias i Pujol, Badalona, Spain. + + + + Millat-Martinez + Pere + P + + ISGlobal, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain. + + + + Durkalski-Mauldin + Valerie + V + + Medical University of South Carolina, Charleston, SCUSA. + + + + Korley + Frederick K + FK + + University of Michigan, Ann Arbor, MIUSA. + + + + Dumont + Larry J + LJ + + Vitalant Research Institute, Denver, CO; University of Colorado School of Medicine, Aurora, CO USA. + + + + Callaway + Clifton W + CW + + University of Pittsburgh, Pittsburgh, PAUSA. + + + + Libster + Romina + R + + Fundación INFANT, Buenos Aires, Argentina. + + + Vanderbilt University, Nashville, TN, USA. + + + + Marc + Gonzalo Perez + GP + + Fundación INFANT, Buenos Aires, Argentina. + + + + Wappner + Diego + D + + Fundación INFANT, Buenos Aires, Argentina. + + + + Esteban + Ignacio + I + + Fundación INFANT, Buenos Aires, Argentina. + + + + Polack + Fernando + F + + Fundación INFANT, Buenos Aires, Argentina. + + + Vanderbilt University, Nashville, TN, USA. + + + + Sullivan + David J + DJ + + Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Clin Infect Dis + 9203213 + 1058-4838 + + IM + + COVID-19 + COVID-19 convalescent plasma + SARS-CoV-2 + hospitalization + therapy + +
+ + + + 2022 + 10 + 26 + + + 2023 + 01 + 06 + + + 2023 + 02 + 14 + + + 2023 + 2 + 22 + 13 + 49 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809473 + 7048396 + 10.1093/cid/ciad088 + + +
+ + + 36809475 + + 2023 + 02 + 22 + +
+ + 2194-7899 + + 11 + 1 + + 2023 + Feb + 21 + + + Health & justice + Health Justice + + The impact of correctional officer gender on prison suicide. + + 10 + + 10.1186/s40352-023-00214-z + + Correctional officers are critical members of the prison community. However, scholarship rarely considers how correctional officers contribute to prison outcomes instead largely focusing on importation (individual) and deprivation (organizational) factors related to the incarcerated population. This is also true regarding how scholars and practitioners approach suicide committed by incarcerated people, one of the leading causes of death in US carceral institutions. Using quantitative data from confinement facilities across the United States, this study answers the research question: What is the relationship between prison suicide rates and correctional officer gender? Results show that deprivation factors (variables related to the carceral environment) influence prison suicide. Additionally, gender diversity among correctional officers reduces the rate of prison suicide. Implications for future research and practice and limitations of the study are also discussed. + © 2023. The Author(s). + + + + Carter + TaLisa J + TJ + http://orcid.org/0000-0002-1662-6089 + + Department of Justice, Law, and Criminology, American University, Massachusetts Avenue, NW Washington, DC, 20016, USA. carter@american.edu. + + + + Whittle + Tanya N + TN + + Department of Sociology and Criminal Justice, Delaware State University, Dover, USA. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Health Justice + 101626355 + 2194-7899 + + + Correctional Officer + Deprivation + Gender + Importation + Suicide + +
+ + + + 2022 + 10 + 24 + + + 2023 + 02 + 09 + + + 2023 + 2 + 22 + 13 + 49 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809475 + 10.1186/s40352-023-00214-z + 10.1186/s40352-023-00214-z + + + + Acker, J. (1992). From Sex Roles to Gendered Institutions. Contemporary Sociology, 21(5), 565–569. https://doi.org/10.2307/2075528 + + 10.2307/2075528 + + + + Anno, B. J. (1985). Patterns of suicide in the Texas Department of Corrections 1980–1985. Journal of Prison & Jail Health, 5(2), 82–93 + + + Anson, R. H., & Cole, J. N. (1984). Inmate suicide: ethnic adaptations to the prisonization experience research note. Justice Quarterly, 1, 563–568 + + 10.1080/07418828400088311 + + + + Bland, R. C., Newman, S. C., Thompson, A. H., & Dyck, R. J. (1998). Psychiatric disorders in the population and in prisoners. International Journal of Law and Psychiatry, 21(3), 273–279. https://doi.org/10.1016/S0160-2527(98)00005-3 + + 10.1016/S0160-2527(98)00005-3 + + + + Britton, D. M. 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+ + + 36809480 + + 2023 + 02 + 22 + +
+ + 2050-7518 + + + 2023 + Feb + 21 + + + Journal of materials chemistry. B + J Mater Chem B + + Gold nanoparticles: promising biomaterials for osteogenic/adipogenic regulation in bone repair. + 10.1039/d2tb02563a + + Bone defects are a common bone disease, which are usually caused by accidents, trauma and tumors. However, the treatment of bone defects is still a great clinical challenge. In recent years, research on bone repair materials has continued with great success, but there are few reports on the repair of bone defects at a high lipid level. Hyperlipidemia is a risk factor in the process of bone defect repair, which has a negative impact on the process of osteogenesis, increasing the difficulty of bone defect repair. Therefore, it is necessary to find materials that can promote bone defect repair under the condition of hyperlipidemia. Gold nanoparticles (AuNPs) have been applied in the fields of biology and clinical medicine for many years and developed to modulate osteogenic differentiation and adipogenic differentiation. In vitro and vivo studies displayed that they promoted bone formation and inhibited fat accumulation. Further, the metabolism and mechanisms of AuNPs acting on osteogenesis/adipogenesis were partially revealed by researchers. This review further clarifies the role of AuNPs in osteogenic/adipogenic regulation during the process of osteogenesis and bone regeneration by summarizing the related in vitro and in vivo research, discussing the advantages and challenges of AuNPs and highlighting several possible directions for future research, with the aim to provide a new strategy for dealing with bone defects in hyperlipidemic patients. + + + + Qiao + Mingxin + M + + State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chengdu 610041, China. jujoy1202@163.com. + + + Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China. champion@scu.edu.cn. + + + + Tang + Wen + W + + State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chengdu 610041, China. jujoy1202@163.com. + + + + Xu + Zhengyi + Z + + State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chengdu 610041, China. jujoy1202@163.com. + + + Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China. champion@scu.edu.cn. + + + + Wu + Xiaoyue + X + + State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chengdu 610041, China. jujoy1202@163.com. + + + + Huang + Wei + W + + State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chengdu 610041, China. jujoy1202@163.com. + + + + Zhu + Zhou + Z + http://orcid.org/0000-0003-3324-483X + + State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chengdu 610041, China. jujoy1202@163.com. + + + Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China. champion@scu.edu.cn. + + + + Wan + Qianbing + Q + http://orcid.org/0000-0002-0028-5881 + + State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chengdu 610041, China. jujoy1202@163.com. + + + Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China. champion@scu.edu.cn. + + + + eng + + Journal Article + Review + + + 2023 + 02 + 21 + +
+ + England + J Mater Chem B + 101598493 + 2050-750X + + IM +
+ + + + 2023 + 2 + 22 + 13 + 49 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809480 + 10.1039/d2tb02563a + + +
+ + + 36809484 + + 2023 + 02 + 22 + +
+ + 2168-4804 + + + 2023 + Feb + 21 + + + Therapeutic innovation & regulatory science + Ther Innov Regul Sci + + An Improved Matching Practice for Augmenting a Randomized Clinical Trial with External Control. + 10.1007/s43441-023-00497-2 + + The use of information from real world to assess the effectiveness of medical products is becoming increasingly popular and more acceptable by regulatory agencies. According to a strategic real-world evidence framework published by U.S. Food and Drug Administration, a hybrid randomized controlled trial that augments internal control arm with real-world data is a pragmatic approach worth more attention. In this paper, we aim to improve on existing matching designs for such a hybrid randomized controlled trial. In particular, we propose to match the entire concurrent randomized clinical trial (RCT) such that (1) the matched external control subjects used to augment the internal control arm are as comparable as possible to the RCT population, (2) every active treatment arm in an RCT with multiple treatments is compared with the same control group, and (3) matching can be conducted and the matched set locked before treatment unblinding to better maintain the data integrity and increase the credibility of the analysis. Besides a weighted estimator, we also introduce a bootstrap method to obtain its variance estimation. The finite sample performance of the proposed method is evaluated by simulations based on data from a real clinical trial. + © 2023. The Author(s), under exclusive licence to The Drug Information Association, Inc. + + + + Li + Jianghao + J + + Department of Biometrics, Eli Lilly and Company, Indianapolis, IN, USA. + + + + Du + Yu + Y + + Department of Biometrics, Eli Lilly and Company, Indianapolis, IN, USA. + + + + Liu + Huayu + H + + Department of Biometrics, Eli Lilly and Company, Indianapolis, IN, USA. + + + + Yi + Yanyao + Y + http://orcid.org/0000-0003-1540-1862 + + Department of Biometrics, Eli Lilly and Company, Indianapolis, IN, USA. yi_yanyao@lilly.com. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Switzerland + Ther Innov Regul Sci + 101597411 + 2168-4790 + + IM + + External control + Matching without replacement + Propensity score + Real-world data + Real-world evidence + +
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+ + + 36809482 + + 2023 + 02 + 22 + +
+ + 1559-0259 + + + 2023 + Feb + 21 + + + Cardiovascular toxicology + Cardiovasc Toxicol + + Molecular Cardiotoxic Effects of Proteasome Inhibitors Carfilzomib and Ixazomib and Their Combination with Dexamethasone Involve Mitochondrial Dysregulation. + 10.1007/s12012-023-09785-7 + + With the development and approval of new proteasome inhibitors, proteasome inhibition is increasingly recognized in cancer therapy. Besides successful anti-cancer effects in hematological cancers, side effects such as cardiotoxicity are limiting effective treatment. In this study, we used a cardiomyocyte model to investigate the molecular cardiotoxic mechanisms of carfilzomib (CFZ) and ixazomib (IXZ) alone or in combination with the immunomodulatory drug dexamethasone (DEX) which is frequently used in combination therapies in the clinic. According to our findings, CFZ showed a higher cytotoxic effect at lower concentrations than IXZ. DEX combination attenuated the cytotoxicity for both proteasome inhibitors. All drug treatments caused a marked increase in K48 ubiquitination. Both CFZ and IXZ caused an upregulation in cellular and endoplasmic reticulum stress protein (HSP90, HSP70, GRP94, and GRP78) levels and DEX combination attenuated the increased stress protein levels. Importantly, IXZ and IXZ-DEX treatments caused upregulation of mitochondria fission and fusion gene expression levels higher than caused by CFZ and CFZ-DEX combination. The IXZ-DEX combination reduced the levels of OXPHOS proteins (Complex II-V) more than the CFZ-DEX combination. Reduced mitochondrial membrane potential and ATP production were detected with all drug treatments in cardiomyocytes. Our findings suggest that the cardiotoxic effect of proteasome inhibitors may be due to their class effect and stress response and mitochondrial dysfunction may be involved in the cardiotoxicity process. + © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. + + + + Jannuzzi + Ayse Tarbin + AT + + Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Istanbul University, Istanbul, Turkey. tarbin.cevik@istanbul.edu.tr. + + + + Korkmaz + Nalan Sümeyra + NS + + Department of Biochemistry, School of Medicine/Genetic and Metabolic Diseases Research and Investigation Center, Marmara University, Istanbul, Turkey. + + + + Gunaydin Akyildiz + Aysenur + A + + Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Bezmialem Vakif University, Istanbul, Turkey. + + + + Arslan Eseryel + Sema + S + + Department of Biochemistry, School of Medicine/Genetic and Metabolic Diseases Research and Investigation Center, Marmara University, Istanbul, Turkey. + + + + Karademir Yilmaz + Betul + B + + Department of Biochemistry, School of Medicine/Genetic and Metabolic Diseases Research and Investigation Center, Marmara University, Istanbul, Turkey. + + + + Alpertunga + Buket + B + + Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Istanbul University, Istanbul, Turkey. + + + Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Istanbul Health and Technology University, Istanbul, Turkey. + + + + eng + + + TSA-2019-33638 + Istanbul University Research Fund + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Cardiovasc Toxicol + 101135818 + 1530-7905 + + IM + + Cardiotoxicity + Mitochondrial toxicity + Proteasome inhibitors + Stress response + +
+ + + + 2022 + 11 + 08 + + + 2023 + 02 + 09 + + + 2023 + 2 + 22 + 13 + 49 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809482 + 10.1007/s12012-023-09785-7 + 10.1007/s12012-023-09785-7 + + + + Wu, P., Oren, O., Gertz, M. A., & Yang, E. H. (2020). Proteasome inhibitor-related cardiotoxicity: Mechanisms, diagnosis, and management. Current Oncology Reports, 22(7), 1–14. + + 10.1007/s11912-020-00931-w + + + + Shah, C., Bishnoi, R., Jain, A., Bejjanki, H., Xiong, S., Wang, Y., Zou, F., & Moreb, J. S. (2018). Cardiotoxicity associated with carfilzomib: Systematic review and meta-analysis. Leukemia & lymphoma, 59(11), 2557–2569. + + 10.1080/10428194.2018.1437269 + + + + Jouni, H., Aubry, M. C., Lacy, M. Q., Kumar, S. K., Frye, R. L., & Herrmann, J. (2017). Ixazomib cardiotoxicity: A possible class effect of proteasome inhibitors. American Journal of Hematology, 92(2), 220–221. + + 10.1002/ajh.24608 + 27859518 + + + + Shirley, M. (2016). 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+ + + 36809483 + + 2023 + 02 + 22 + +
+ + 1432-2307 + + + 2023 + Feb + 21 + + + Virchows Archiv : an international journal of pathology + Virchows Arch + + Artificial intelligence-assisted cancer diagnosis improves the efficiency of pathologists in prostatic biopsies. + 10.1007/s00428-023-03518-5 + + Paige Prostate is a clinical-grade artificial intelligence tool designed to assist the pathologist in detecting, grading, and quantifying prostate cancer. In this work, a cohort of 105 prostate core needle biopsies (CNBs) was evaluated through digital pathology. Then, we compared the diagnostic performance of four pathologists diagnosing prostatic CNB unaided and, in a second phase, assisted by Paige Prostate. In phase 1, pathologists had a diagnostic accuracy for prostate cancer of 95.00%, maintaining their performance in phase 2 (93.81%), with an intraobserver concordance rate between phases of 98.81%. In phase 2, pathologists reported atypical small acinar proliferation (ASAP) less often (about 30% less). Additionally, they requested significantly fewer immunohistochemistry (IHC) studies (about 20% less) and second opinions (about 40% less). The median time required for reading and reporting each slide was about 20% lower in phase 2, in both negative and cancer cases. Lastly, the average total agreement with the software performance was observed in about 70% of the cases, being significantly higher in negative cases (about 90%) than in cancer cases (about 30%). Most of the diagnostic discordances occurred in distinguishing negative cases with ASAP from small foci of well-differentiated (less than 1.5 mm) acinar adenocarcinoma. In conclusion, the synergic usage of Paige Prostate contributes to a significant decrease in IHC studies, second opinion requests, and time for reporting while maintaining highly accurate diagnostic standards. + © 2023. The Author(s). + + + + Eloy + Catarina + C + + Pathology Laboratory, Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal. + + + i3S - Instituto de Investigação E Inovação Em Saúde, Porto, Portugal. + + + Faculty of Medicine, University of Porto, Porto, Portugal. + + + + Marques + Ana + A + + Pathology Laboratory, Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal. + + + Serviço de Anatomia Patológica, Centro Hospitalar Universitário de São João, Porto, Portugal. + + + + Pinto + João + J + + Pathology Laboratory, Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal. + + + Serviço de Anatomia Patológica, Hospital Pedro Hispano - Unidade Local de Saúde de Matosinhos, Matosinhos, Portugal. + + + + Pinheiro + Jorge + J + + Pathology Laboratory, Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal. + + + Serviço de Anatomia Patológica, Centro Hospitalar Universitário de São João, Porto, Portugal. + + + + Campelos + Sofia + S + + Pathology Laboratory, Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal. + + + + Curado + Mónica + M + + Pathology Laboratory, Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal. + + + + Vale + João + J + + Pathology Laboratory, Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal. + + + + Polónia + António + A + http://orcid.org/0000-0001-8312-1681 + + Pathology Laboratory, Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal. antoniopolonia@yahoo.com. + + + i3S - Instituto de Investigação E Inovação Em Saúde, Porto, Portugal. antoniopolonia@yahoo.com. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Virchows Arch + 9423843 + 0945-6317 + + IM + + Artificial intelligence + Computational pathology + Digital pathology + Prostate cancer + +
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+ + 1548-3576 + + + 2023 + Feb + 21 + + + Current HIV/AIDS reports + Curr HIV/AIDS Rep + + Update on Central Nervous System Effects of HIV in Adolescents and Young Adults. + 10.1007/s11904-023-00651-3 + + : Behaviorally acquired (non-perinatal) HIV infection during adolescence and young adulthood occurs in the midst of key brain developmental processes such as frontal lobe neuronal pruning and myelination of white matter, but we know little about the effects of new infection and therapy on the developing brain. + Adolescents and young adults account for a disproportionately high fraction of new HIV infections each year. Limited data exist regarding neurocognitive performance in this age group, but suggest impairment is at least as prevalent as in older adults, despite lower viremia, higher CD4 + T cell counts, and shorter durations of infection in adolescents/young adults. Neuroimaging and neuropathologic studies specific to this population are underway. The full impact of HIV on brain growth and development in youth with behaviorally acquired HIV has yet to be determined; it must be investigated further to develop future targeted treatment and mitigation strategies. + © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. + + + + McGuire + Jennifer L + JL + http://orcid.org/0000-0002-8245-7199 + + Division of Neurology, Children's Hospital of Philadelphia, 3501 Civic Center Blvd, Philadelphia, PA, 19104, USA. mcguirej@chop.edu. + + + Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. mcguirej@chop.edu. + + + Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. mcguirej@chop.edu. + + + + Grinspan + Judith B + JB + http://orcid.org/0000-0003-0940-5314 + + Division of Neurology, Children's Hospital of Philadelphia, 3501 Civic Center Blvd, Philadelphia, PA, 19104, USA. + + + Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. + + + + Jordan-Sciutto + Kelly L + KL + http://orcid.org/0000-0002-0827-1337 + + Department of Oral Medicine, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA. + + + + eng + + + K23 NS094069 + NS + NINDS NIH HHS + United States + + + R01 MH126773 + MH + NIMH NIH HHS + United States + + + R01 MH126773 + MH + NIMH NIH HHS + United States + + + R01 MH126773 + MH + NIMH NIH HHS + United States + + + R01 MH098742 + MH + NIMH NIH HHS + United States + + + R01 MH098742 + MH + NIMH NIH HHS + United States + + + + Journal Article + Review + + + 2023 + 02 + 21 + +
+ + United States + Curr HIV/AIDS Rep + 101235661 + 1548-3568 + + IM + + Adolescents + Brain + Complement + HAND + HIV + HIV-associated neurocognitive disorders + Oligodendrocyte + +
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+ + + 36809485 + + 2023 + 02 + 22 + +
+ + 1556-2891 + + + 2023 + Feb + 21 + + + Forensic science, medicine, and pathology + Forensic Sci Med Pathol + + Micromorphological features and interleukin 6, 8, and 18 expressions in post-mortem lung tissue in cases with acute respiratory distress syndrome. + 10.1007/s12024-022-00572-4 + + The purpose of this study was to analyze the presence of interleukins 6, 8, and 18 in post-mortem lung tissue of subjects deceased due to polytrauma. In addition to this, we have described different micromorphological features of lung tissue in ARDS cases associated with fatal traffic trauma. A total of 18 autopsy cases with ARDS after polytrauma and 15 control autopsy cases were analyzed in this study. From every subject, we collected one sample for each lung lobe. All of the histological sections were analyzed by using light microscopy, and for the purpose of ultrastructural analysis, we used transmission electron microscopy. Representative sections were further processed by way of immunohistochemistry analysis. Quantification of IL-6, IL-8, and IL-18-positive cells was conducted by applying the IHC score. We noticed that all samples of ARDS cases exhibited elements of the proliferative phase. Immunohistochemical analysis of lung tissue in patients with ARDS showed strong positive staining for IL-6 (2.8 ± 0.7), IL-8 (2.2 ± 1.3), and IL-18 (2.7 ± 1.2), while staining of the control samples resulted in no positivity to low/moderate positivity (for IL-6 1.4 ± 0.5; for IL-8 0.1 ± 0.4; for IL-18 0.6 ± 0.9). Only IL-6 correlated negatively with the patients' age (r =  -0.6805, p < 0.01). In this study, we described microstructural changes in lung sections of ARDS cases and control cases, as well as interleukins' expression, demonstrating that autopsy material is as informing as tissue samples collected by performing open lung biopsy. + © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. + + + + Kuzmanović + Jelena + J + + Pathology Department, University Medical Centre Zvezdara, Belgrade, Serbia. + + + + Savić + Slobodan + S + + Institute of Forensic Medicine "Dr Milovan Milovanovic", Faculty of Medicine, University of Belgrade, Belgrade, Serbia. + + + + Bogdanović + Milenko + M + + Institute of Forensic Medicine "Dr Milovan Milovanovic", Faculty of Medicine, University of Belgrade, Belgrade, Serbia. drbogdanovicm@gmail.com. + + + + Martinović + Tamara + T + + Institute of Histology and Embryology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia. + + + + Bumbaširević + Vladimir + V + + Institute of Histology and Embryology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia. + + + Serbian Academy of Sciences and Arts, Belgrade, Serbia. + + + + Stevović + Tamara Kravić + TK + + Institute of Histology and Embryology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Forensic Sci Med Pathol + 101236111 + 1547-769X + + IM + + ARDS + Autopsy + IL-18 + IL-6 + IL-8 + Trauma + +
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Clin Chest Med. 2000;21(3):435–66. https://doi.org/10.1016/s0272-5231(05)70158-1 . + + 10.1016/s0272-5231(05)70158-1 + 11019719 + + + + Papazian L, Thomas P, Bregeon F, Garbe L, Zandotti C, Saux P, Gaillat F, Drancourt M, Auffray JP, Gouin F. Open-lung biopsy in patients with acute respiratory distress syndrome. Anesthesiology. 1998;88(4):935–44. https://doi.org/10.1097/00000542-199804000-00013 . + + 10.1097/00000542-199804000-00013 + 9579502 + + + + Hill JD, Ratliff JL, Parrott JC, Lamy M, Fallat RJ, Koeniger E, Yaeger EM, Whitmer G. Pulmonary pathology in acute respiratory insufficiency: lung biopsy as a diagnostic tool. J Thorac Cardiovasc Surg. 1976;71(1):64–71. + + 10.1016/S0022-5223(19)40261-4 + 765628 + + + + Barbas CS, Capelozzi VL, Hoelz C, Magaldi RB, de Souza R, Sandeville ML, de Campos JR, Werebe E, Andrade Filho LO, Knobel E. Impact of open lung biopsy on refractory acute respiratory failure. J Bras Pneumol. 2006;32(5):418–23. + + 10.1590/S1806-37132006000500008 + 17268745 + + + + Fraire AE, Cooper SP, Greenberg SD, Rowland LP, Langston C. Transbronchial lung biopsy. Histopathologic and morphometric assessment of diagnostic utility. Chest. 1992;102(3):748–52. https://doi.org/10.1378/chest.102.3.748 . + + 10.1378/chest.102.3.748 + 1516396 + + + + Allen TC, Fudala R, Nash SE, Kurdowska A. Anti-interleukin 8 autoantibody: interleukin 8 immune complexes visualized by laser confocal microscopy in injured lung. Arch Pathol Lab Med. 2007;131(3):452–6. https://doi.org/10.5858/2007-131-452-AAICVB . + + 10.5858/2007-131-452-AAICVB + 17516748 + + + + Allen TC, Kurdowska A. Interleukin 8 and acute lung injury. Arch Pathol Lab Med. 2014;138(2):266–9. https://doi.org/10.5858/arpa.2013-0182-RA . + + 10.5858/arpa.2013-0182-RA + 23782136 + + + + Capelozzi VL, Allen TC, Beasley MB, Cagle PT, Guinee D, Hariri LP, et al. Molecular and immune biomarkers in acute respiratory distress syndrome: a perspective from members of the Pulmonary Pathology Society. Arch Pathol Lab Med. 2017;141(12):1719–27. https://doi.org/10.5858/arpa.2017-0115-SA . + + 10.5858/arpa.2017-0115-SA + 28613912 + + + + Ware LB, Koyama T, Zhao Z, Janz DR, Wickersham N, Bernard GR, May AK, Calfee CS, Matthay MA. Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome. Crit Care. 2013;17(5):R253. https://doi.org/10.1186/cc13080 . + + 10.1186/cc13080 + 24156650 + 4056313 + + + + Dolinay T, Kim YS, Howrylak J, Hunninghake GM, An CH, Fredenburgh L, et al. Inflammasome-regulated cytokines are critical mediators of acute lung injury. Am J Respir Crit Care Med. 2012;185(11):1225–34. https://doi.org/10.1164/rccm.201201-0003OC . Epub 2012 Mar 29. + + 10.1164/rccm.201201-0003OC + 22461369 + 3373064 + + + + Fujishima S. Pathophysiology and biomarkers of acute respiratory distress syndrome. J Intensive Care. 2014;2(1):32. https://doi.org/10.1186/2052-0492-2-32 . + + 10.1186/2052-0492-2-32 + 25520844 + 4267590 + + + + Bime C, Casanova N, Oita RC, Ndukum J, Lynn H, Camp SM, et al. Development of a biomarker mortality risk model in acute respiratory distress syndrome. Crit Care. 2019;23(1):410. https://doi.org/10.1186/s13054-019-2697-x . + + 10.1186/s13054-019-2697-x + 31842964 + 6916252 + + + + Chen S, Yang C, Zhu L, Jiang J. Plasma protein biomarkers of ALI and ARDS. Intern Clin Exp Med. 2017;10(8):12308–14. + + + Unver N, McAllister F. IL-6 family cytokines: Key inflammatory mediators as biomarkers and potential therapeutic targets. Cytokine Growth Factor Rev. 2018;41:10–7. https://doi.org/10.1016/j.cytogfr.2018.04.004 . Epub 2018 Apr 18. + + 10.1016/j.cytogfr.2018.04.004 + 29699936 + 6085880 + + + + Swaroopa D, Bhaskar K, Mahathi T, Katkam S, Raju YS, Chandra N, Kutala VK. Association of serum interleukin-6, interleukin-8, and Acute Physiology and Chronic Health Evaluation II score with clinical outcome in patients with acute respiratory distress syndrome. Indian J Crit Care Med. 2016;20(9):518–25. https://doi.org/10.4103/0972-5229.190369 . + + 10.4103/0972-5229.190369 + 27688627 + 5027744 + + + + Pires-Neto RC, Morales MM, Lancas T, Inforsato N, Duarte MI, Amato MB, de Carvalho CR, da Silva LF, Mauad T, Dolhnikoff M. Expression of acute-phase cytokines, surfactant proteins, and epithelial apoptosis in small airways of human acute respiratory distress syndrome. J Crit Care. 2013;28(1):111.e9-111.e15. https://doi.org/10.1016/j.jcrc.2012.05.013 . + + 10.1016/j.jcrc.2012.05.013 + 22835422 + + + + Kasotakis G, Stanfield B, Haines K, Vatsaas C, Alger A, Vaslef SN, Brooks K, Agarwal S. Acute respiratory distress syndrome (ARDS) after trauma: improving incidence, but increasing mortality. J Crit Care. 2021;64:213–8. https://doi.org/10.1016/j.jcrc.2021.05.003 . + + 10.1016/j.jcrc.2021.05.003 + 34022661 + + + + Huber-Lang M, Lambris JD, Ward PA. Innate immune responses to trauma. Nat Immunol. 2018;19(4):327–41. https://doi.org/10.1038/s41590-018-0064-8 . + + 10.1038/s41590-018-0064-8 + 29507356 + 6027646 + + + + Niesler U, Palmer A, Radermacher P, Huber-Lang MS. Role of alveolar macrophages in the inflammatory response after trauma. Shock. 2014;42(1):3–10. https://doi.org/10.1097/SHK.0000000000000167 . + + 10.1097/SHK.0000000000000167 + 24667621 + + + + +
+ + + 36809486 + + 2023 + 02 + 22 + +
+ + 1540-7748 + + 155 + 5 + + 2023 + May + 01 + + + The Journal of general physiology + J Gen Physiol + + Mechanism of external K+ sensitivity of KCNQ1 channels. + e202213205 + 10.1085/jgp.202213205 + + KCNQ1 voltage-gated K+ channels are involved in a wide variety of fundamental physiological processes and exhibit the unique feature of being markedly inhibited by external K+. Despite the potential role of this regulatory mechanism in distinct physiological and pathological processes, its exact underpinnings are not well understood. In this study, using extensive mutagenesis, molecular dynamics simulations, and single-channel recordings, we delineate the molecular mechanism of KCNQ1 modulation by external K+. First, we demonstrate the involvement of the selectivity filter in the external K+ sensitivity of the channel. Then, we show that external K+ binds to the vacant outermost ion coordination site of the selectivity filter inducing a diminution in the unitary conductance of the channel. The larger reduction in the unitary conductance compared to whole-cell currents suggests an additional modulatory effect of external K+ on the channel. Further, we show that the external K+ sensitivity of the heteromeric KCNQ1/KCNE complexes depends on the type of associated KCNE subunits. + © 2023 Abrahamyan et al. + + + + Abrahamyan + Astghik + A + 0000-0001-8561-050X + + Molecular Neuroscience Group, Institute of Molecular Biology, National Academy of Sciences of the Republic of Armenia , Yerevan, Armenia. + https://ror.org/03t8mqd25 + + + + Eldstrom + Jodene + J + 0000-0002-7684-175X + + Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia , Vancouver, BC, Canada. + https://ror.org/03rmrcq20 + + + + Sahakyan + Harutyun + H + 0000-0003-3750-8118 + + Laboratory of Computational Modeling of Biological Processes, Institute of Molecular Biology of National Academy of Sciences of the Republic of Armenia , Yerevan, Armenia. + https://ror.org/03t8mqd25 + + + + Karagulyan + Nare + N + + Molecular Neuroscience Group, Institute of Molecular Biology, National Academy of Sciences of the Republic of Armenia , Yerevan, Armenia. + https://ror.org/03t8mqd25 + + + + Mkrtchyan + Liana + L + + Molecular Neuroscience Group, Institute of Molecular Biology, National Academy of Sciences of the Republic of Armenia , Yerevan, Armenia. + https://ror.org/03t8mqd25 + + + + Karapetyan + Tatev + T + + Molecular Neuroscience Group, Institute of Molecular Biology, National Academy of Sciences of the Republic of Armenia , Yerevan, Armenia. + https://ror.org/03t8mqd25 + + + + Sargsyan + Ernest + E + + Molecular Neuroscience Group, Institute of Molecular Biology, National Academy of Sciences of the Republic of Armenia , Yerevan, Armenia. + https://ror.org/03t8mqd25 + + + + Kneussel + Matthias + M + 0000-0003-4900-366X + + Institute for Molecular Neurogenetics, Center for Molecular Neurobiology Hamburg , Hamburg, Germany. + + + + Nazaryan + Karen + K + 0000-0002-5231-3928 + + Laboratory of Computational Modeling of Biological Processes, Institute of Molecular Biology of National Academy of Sciences of the Republic of Armenia , Yerevan, Armenia. + https://ror.org/03t8mqd25 + + + + Schwarz + Jürgen R + JR + + Institute for Molecular Neurogenetics, Center for Molecular Neurobiology Hamburg , Hamburg, Germany. + + + + Fedida + David + D + 0000-0001-6797-5185 + + Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia , Vancouver, BC, Canada. + https://ror.org/03rmrcq20 + + + + Vardanyan + Vitya + V + 0000-0001-6731-036X + + Molecular Neuroscience Group, Institute of Molecular Biology, National Academy of Sciences of the Republic of Armenia , Yerevan, Armenia. + https://ror.org/03t8mqd25 + + + + eng + + + AZ 86659 + Volkswagen Foundation + + + + RGPIN-2016-05422 + Natural Sciences and Engineering Research Council of Canada + + + + PJT-156181 + Canadian Institutes of Health Research + Canada + + + G17-0018392 + Heart and Stroke Foundation of Canada + + + + Molbiol 4057 + Armenian National Science and Education Fund + + + + 22729/2017 + Swedish Institute + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + J Gen Physiol + 2985110R + 0022-1295 + + IM +
+ + + + 2022 + 05 + 31 + + + 2022 + 12 + 20 + + + 2023 + 01 + 31 + + + 2023 + 2 + 22 + 13 + 50 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809486 + 213880 + 10.1085/jgp.202213205 + + +
+ + + 36809494 + + 2023 + 02 + 22 + +
+ + 1869-6953 + + + 2023 + Feb + 21 + + + Diabetes therapy : research, treatment and education of diabetes and related disorders + Diabetes Ther + + Use of iGlarLixi for the Management of Type 2 Diabetes in Japanese Clinical Practice: Prior Treatment Subgroup Analysis of the SPARTA Japan Study. + 10.1007/s13300-023-01373-w + + iGlarLixi, a fixed-ratio combination of insulin glargine 100 U/mL and the glucagon-like peptide 1 receptor agonist (GLP-1 RA) lixisenatide, is one option for treatment intensification in individuals with type 2 diabetes (T2D) who are unable to achieve targeted glycaemic control with their current glucose-lowering agent. Real-world data on the impact of prior treatment on the effectiveness and safety of iGlarLixi may be useful to guide individualised treatment decisions. + This analysis of the 6-month, retrospective, observational SPARTA Japan study compared glycated haemoglobin (HbA1c), body weight and safety for pre-specified subgroups defined by prior treatment: post oral antidiabetic agent (OAD), GLP-1 RA, basal insulin (BI) + OADs (BOT), GLP-1 RA + BI or multiple daily injections (MDI). The post BOT and MDI subgroups were further divided on the basis of prior dipeptidyl peptidase 4 inhibitor (DPP-4i) use, and the post MDI group was divided on the basis of whether participants continued bolus insulin. + Of the 432 participants in the full analysis set (FAS), 337 were included in this subgroup analysis. Across subgroups, mean baseline HbA1c ranged from 8.49% to 9.18%. iGlarLixi significantly (p < 0.05) reduced mean HbA1c from baseline in all but the post GLP-1 RA + BI group. At 6 months, these significant reductions ranged from 0.47% to 1.27%. Prior DPP-4i exposure had no impact on the HbA1c-lowering effect of iGlarLixi. Mean body weight decreased significantly in the FAS (0.5 kg) and the post BOT (1.2 kg) and MDI (1.5 and 1.9 kg) subgroups but increased in the post GLP-1 RA subgroup (1.3 kg). iGlarLixi treatment was generally well tolerated, with very few participants discontinuing because of hypoglycaemia or gastrointestinal events. + In participants with suboptimal glycaemic control on various regimens, 6 months of iGlarLixi treatment improved HbA1c in all but one prior treatment subgroup (GLP-1 RA + BI), and was generally well tolerated. + UMIN-CTR Trials Registry, UMIN000044126; registered 10 May 2021. + © 2023. The Author(s). + + + + Miyoshi + Hideaki + H + http://orcid.org/0000-0002-5909-3243 + + Department of Immunology and Metabolism, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan. + + + + Matsuhisa + Munehide + M + http://orcid.org/0000-0003-4624-939X + + Diabetes Therapeutics and Research Center, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan. + + + + Yabe + Daisuke + D + http://orcid.org/0000-0002-5334-7687 + + Department of Diabetes, Endocrinology and Metabolism, and Department of Rheumatology and Clinical Immunology, Gifu University Graduate School of Medicine, Gifu, Japan. + + + + Takahashi + Yoko + Y + http://orcid.org/0000-0003-2481-9574 + + General Medicine Medical, Sanofi K.K., Opera City Tower 3-20-2, Nishi-Shinjuku, Shinjuku-ku, Tokyo, 163-1488, Japan. Yoko.Takahashi@sanofi.com. + + + + Morimoto + Yukiko + Y + + Real World Evidence Generation Partnering, Sanofi K.K., Tokyo, Japan. + + + + Terauchi + Yasuo + Y + http://orcid.org/0000-0002-8872-3697 + + Department of Endocrinology and Metabolism, Graduate School of Medicine, Yokohama City University, Yokohama, Japan. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Diabetes Ther + 101539025 + 1869-6961 + + + Despite initially receiving oral treatment for their diabetes, many individuals with type 2 diabetes are unable to achieve their blood glucose targets and require treatment intensification as their disease progresses. In these individuals, options for treatment intensification include adding an injectable therapy, such as a glucagon-like peptide 1 receptor agonist or basal insulin, or the combination of both. However, the impact of previously received treatments on the ability of treatment intensification to improve outcomes in these individuals has yet to be evaluated. Here, we report the findings of an analysis that aimed to determine the influence of different treatment backgrounds on the effectiveness and safety of iGlarLixi, a fixed-ratio combination (i.e. combined as a single subcutaneous injection) of the glucagon-like peptide 1 receptor agonist lixisenatide and basal insulin glargine 100 U/mL, in Japanese individuals with type 2 diabetes. We found that iGlarLixi improved glycaemic control and was well tolerated in most individuals, regardless of previously received treatments. These results suggest that iGlarLixi may offer an effective option for improving outcomes in Japanese individuals with type 2 diabetes who require treatment intensification. + + + Fixed-ratio combination + Insulin glargine + Japan + Lixisenatide + Real-world data + Type 2 diabetes mellitus + iGlarLixi + +
+ + + + 2022 + 11 + 14 + + + 2023 + 01 + 23 + + + 2023 + 2 + 22 + 13 + 50 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809494 + 10.1007/s13300-023-01373-w + 10.1007/s13300-023-01373-w + + + + Kohsaka S, Morita N, Okami S, Kidani Y, Yajima T. Current trends in diabetes mellitus database research in Japan. Diabetes Obes Metab. 2021;23:3–18. + + 10.1111/dom.14325 + 33835639 + + + + Maegawa H, Ishigaki Y, Langer J, Saotome-Nakamura A, Andersen M. Clinical inertia in patients with type 2 diabetes treated with oral antidiabetic drugs: results from a Japanese cohort study (JDDM53). J Diabetes Investig. 2021;12(3):374–81. + + 10.1111/jdi.13352 + 32643314 + + + + Baxter M, Morimoto Y, Tamiwa M, et al. A real-world observational study evaluating the probability of glycemic control with basal insulin or glucagon-like peptide-1 receptor agonist in Japanese patients with type 2 diabetes. Diabetes Ther. 2020;11(7):1481–96. + + 10.1007/s13300-020-00836-8 + 32445125 + 7324466 + + + + Draznin B, Aroda VR, American Diabetes Association Professional Practice Committee, et al. Pharmacologic approaches to glycemic treatment: standards of medical care in diabetes–2022. Diabetes Care. 2022;45(Suppl 1):S125–43. + + + Yokoyama H, Araki SI, Yamazaki K, et al. Trends in glycemic control in patients with insulin therapy compared with non-insulin or no drugs in type 2 diabetes in Japan: a long-term view of real-world treatment between 2002 and 2018 (JDDM 66). BMJ Open Diabetes Res Care. 2022;10(3): e002727. + + 10.1136/bmjdrc-2021-002727 + 35504696 + 9066475 + + + + Rosenstock J, Aronson R, Grunberger G, et al. Benefits of LixiLan, a titratable fixed-ratio combination of insulin glargine plus lixisenatide, versus insulin glargine and lixisenatide monocomponents in type 2 diabetes inadequately controlled on oral agents: the LixiLan-O randomized trial. Diabetes Care. 2016;39(11):2026–35. + + 10.2337/dc16-0917 + 27527848 + + + + Aroda VR, Rosenstock J, Wysham C, et al. Efficacy and safety of LixiLan, a titratable fixed-ratio combination of insulin glargine plus lixisenatide in type 2 diabetes inadequately controlled on basal insulin and metformin: the LixiLan-L randomized trial. Diabetes Care. 2016;39(11):1972–80. + + 10.2337/dc16-1495 + 27650977 + + + + Kaneto H, Takami A, Spranger R, Amano A, Watanabe D, Niemoeller E. Efficacy and safety of insulin glargine/lixisenatide fixed-ratio combination (iGlarLixi) in Japanese patients with type 2 diabetes mellitus inadequately controlled on basal insulin and oral antidiabetic drugs: the LixiLan JP-L randomized clinical trial. Diabetes Obes Metab. 2020;22(Suppl 4):3–13. + + 10.1111/dom.14005 + 32072742 + + + + Terauchi Y, Nakama T, Spranger R, Amano A, Inoue T, Niemoeller E. Efficacy and safety of insulin glargine/lixisenatide fixed-ratio combination (iGlarLixi 1:1) in Japanese patients with type 2 diabetes mellitus inadequately controlled on oral antidiabetic drugs: a randomized, 26-week, open-label, multicentre study: the LixiLan JP-O2 randomized clinical trial. Diabetes Obes Metab. 2020;22(Suppl 4):14–23. + + 10.1111/dom.14036 + 32291880 + + + + Andreozzi F, Candido R, Corrao S, et al. Clinical inertia is the enemy of therapeutic success in the management of diabetes and its complications: a narrative literature review. Diabetol Metabol Syndr. 2020;12(1):52. + + 10.1186/s13098-020-00559-7 + + + + Blonde L, Anderson JE, Chava P, Dendy JA. Rationale for a titratable fixed-ratio co-formulation of a basal insulin analog and a glucagon-like peptide 1 receptor agonist in patients with type 2 diabetes. Curr Med Res Opin. 2019;35(5):793–804. + + 10.1080/03007995.2018.1541790 + 30370783 + + + + Watada H, Takami A, Spranger R, Amano A, Hashimoto Y, Niemoeller E. Efficacy and safety of 1:1 fixed-ratio combination of insulin glargine and lixisenatide versus lixisenatide in Japanese patients with type 2 diabetes inadequately controlled on oral antidiabetic drugs: the LixiLan JP-O1 randomized clinical trial. Diabetes Care. 2020;43(6):1249–57. + + 10.2337/dc19-2452 + 32295808 + 7245357 + + + + Matsuhisa M, Miyoshi H, Yabe D, Takahashi Y, Morimoto Y, Terauchi Y. Use of iGlarLixi for management of type 2 diabetes in Japanese clinical practice: SPARTA Japan, a retrospective observational study. Diabetes Ther. 2022. https://doi.org/10.1007/s13300-022-01333-w . + + 10.1007/s13300-022-01333-w + 36422802 + 9880089 + + + + Araki E, Goto A, Kondo T, et al. Japanese clinical practice guideline for diabetes 2019. J Diabetes Investig. 2020;11(4):1020–76. + + 10.1111/jdi.13306 + 33021749 + 7378414 + + + + Gallwitz B. Clinical use of DPP-4 inhibitors. Front Endocrinol (Lausanne). 2019;10:389. + + 10.3389/fendo.2019.00389 + 31275246 + + + + Terauchi Y, Yabe D, Kaneto H, et al. Benefits of the fixed-ratio combination of insulin glargine 100 units/mL and lixisenatide (iGlarLixi) in Japanese people with type 2 diabetes: a subgroup and time-to-control analysis of the LixiLan JP phase 3 trials. Diabetes Obes Metab. 2020;22(Suppl 4):35–47. + + 10.1111/dom.14139 + 33404200 + + + + Russell-Jones D, Khan R. Insulin-associated weight gain in diabetes—causes, effects and coping strategies. Diabetes Obes Metab. 2007;9(6):799–812. + + 10.1111/j.1463-1326.2006.00686.x + 17924864 + + + + Heller SR, Peyrot M, Oates SK, Taylor AD. Hypoglycemia in patient with type 2 diabetes treated with insulin: it can happen. BMJ Open Diabetes Res Care. 2020;8(1): e001194. + + 10.1136/bmjdrc-2020-001194 + 32546549 + 7299018 + + + + Candido R, Modugno M, Gabellieri E, et al. Efficacy, safety, and appropriateness of iGlarLixi, a fixed-ratio combination (FRC) in type 2 diabetes (T2D) in real-world settings: results from the ENSURE study [abstract 110-LB]. Diabetes. 2021;70(Suppl 1):110-LB. + + 10.2337/db21-110-LB + + + + Kis JT, Nagy G, Kovacs G. Effectiveness of iGlarLixi, a fixed-ratio combination of insulin glargine 100 U/mL and lixisenatide, in people with type 2 diabetes. Diabetes Ther. 2021;12(9):2517–29. + + 10.1007/s13300-021-01128-5 + 34357560 + 8385086 + + + + Bala C, Cerghizan A, Mihai BM, Moise M, Guja C. Real-world evidence on the use of a fixed-ratio combination of insulin glargine and lixisenatide (iGlarLixi) in people with suboptimally controlled type 2 diabetes in Romania: a prospective cohort study (STAR.Ro). BMJ Open. 2022;12(5):e060852. + + 10.1136/bmjopen-2022-060852 + 35623748 + 9150149 + + + + Davies MJ, Aroda VR, Collins BS, et al. Management of hyperglycemia in type 2 diabetes, 2022. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care. 2022;45(11):2753–86. + + 10.2337/dci22-0034 + 36148880 + + + + Blonde L, Umpierrez GE, Reddy SS, et al. American Association of Clinical Endocrinology Clinical Practice Guideline: developing a diabetes mellitus comprehensive care plan-2022 update. Endocr Pract. 2022;28(10):923–1049. + + 10.1016/j.eprac.2022.08.002 + 35963508 + + + + +
+ + + 36809493 + + 2023 + 02 + 22 + +
+ + 2731-7072 + + + 2023 + Feb + 21 + + + Urologie (Heidelberg, Germany) + Urologie + + [The genesis of informed consent in the context of medical research ethics 1900-1931]. + 10.1007/s00120-023-02042-3 + + At the turn of the 20th century, the problem of human experimentation and the need to obtain consent became more important among medical practitioners and the general public. The case of the venereologist Albert Neisser, among others, is used to trace the development of research ethics standards in Germany between the end of the 19th century and 1931. The concept of informed consent, which originated in research ethics, is also of central importance in clinical ethics today. + © 2023. The Author(s). + + + + Moll + Friedrich H + FH + + Institut für Geschichte, Theorie und Ethik der Medizin, Centre for Health and Society, Medizinische Fakultät, Heinrich-Heine-Universität, Düsseldorf, Deutschland. friedrich.moll@hhu.de. + + + Curator Museum, Bibliothek und Archiv, Deutsche Gesellschaft für Urologie e. V., Düsseldorf-Berlin, Deutschland. friedrich.moll@hhu.de. + + + Urologische Klinik, Urologischer Arbeitsplatz Krankenhaus Merheim, Kliniken der Stadt Köln gGmbH, Neufelder Straße 32, 51067, Köln, Deutschland. friedrich.moll@hhu.de. + + + + Krischel + Matthis + M + + Institut für Geschichte, Theorie und Ethik der Medizin, Centre for Health and Society, Medizinische Fakultät, Heinrich-Heine-Universität, Düsseldorf, Deutschland. + + + + ger + + English Abstract + Journal Article + Review + + Die Genese des Informed Consent im Kontext der medizinischen Forschungsethik 1900–1931. + + 2023 + 02 + 21 + +
+ + Germany + Urologie + 9918384886606676 + 2731-7064 + + IM + + An der Wende zum 20. Jahrhundert rückte die Problematik des Humanexperimentes sowie die Notwendigkeit der Einwilligung hierzu in den Fokus der Mediziner und einer allgemeinen Öffentlichkeit. Es wird u. a. am Fall des Venerologen Albert Neisser die Entwicklung forschungsethischer Standards zwischen dem Ende des 19. Jahrhunderts und 1931 in Deutschland nachgezeichnet. Das aus der Forschungsethik stammende Konzept des Informed Consent ist heute auch in der klinischen Ethik von zentraler Bedeutung. + + + Albert Neisser + Germany + History of medicine + Human experimentation + Medical ethics + +
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+ + 1435-1463 + + + 2023 + Feb + 21 + + + Journal of neural transmission (Vienna, Austria : 1996) + J Neural Transm (Vienna) + + Optimised endoscopic access for intrajejunal levodopa application in idiopathic Parkinson's syndrome. + 10.1007/s00702-023-02601-0 + + Pump-guided intrajejunal levodopa administration is one of the indispensable forms of therapy in advanced Parkinson's syndrome, along with deep brain stimulation and subcutaneous apomorphine injection. The standard application of levodopa gel via a JET-PEG, i.e. a percutaneous endoscopic gastrostomy (PEG) with an inserted internal catheter into the jejunum, has not been unproblematic due to the restricted absorption area of the drug in the region of the flexura duodenojejunalis and especially due to the sometimes considerable accumulated complication rates of a JET-PEG. Causes of complications are mainly a non-optimal application technique of PEG and internal catheter as well as the often missing adequate follow-up care. This article presents the details of a-compared to the conventional technique-modified and optimised application technique, which has been clinically proven successfully for years. However, many details derived from anatomical, physiological, surgical and endoscopic aspects must be strictly observed during the application to reduce or avoid minor and major complications. Local infections and buried bumper syndrome cause particular problems. The relatively frequent dislocations of the internal catheter (which can ultimately be avoided by clip-fixing the catheter tip) also prove to be particularly troublesome. Finally, using the Hybrid technique, a new combination of an endoscopically controlled gastropexy with 3 sutures and subsequent central thread pull-through (TPT) of the PEG tube, the complication rate can be dramatically reduced and thus a decisive improvement achieved for patients. The aspects discussed here are highly relevant for all those involved in the therapy of advanced Parkinson's syndrome. + © 2023. The Author(s). + + + + Grund + K E + KE + + Surgical and Experimental Endoscopy, University Hospital of Tübingen, Tübingen, Germany. k.e.grund@web.de. + + + , Gottwollshaeuser Steige 25, 74523, Schwaebisch Hall, Germany. k.e.grund@web.de. + + + + Zipfel + A + A + + Surgical and Experimental Endoscopy, University Hospital of Tübingen, Tübingen, Germany. + + + + Duckworth-Mothes + B + B + + Working Group for Experimental Endoscopy, Education and Training, Department of General, Visceral and Transplantation Surgery, University Hospital of Tübingen, Tübingen, Germany. + + + + Jost + W H + WH + http://orcid.org/0000-0002-8574-3297 + + Parkinson-Klinik Ortenau, Wolfach, Germany. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Austria + J Neural Transm (Vienna) + 9702341 + 0300-9564 + + IM + + Hybrid-PEG + Idopathic Parkinson syndrome + JET-PEG + Levodopa + +
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San Diego, DDW + + + Warnecke T, Schafer KH et al (2022) Gastrointestinal involvement in Parkinson’s disease: pathophysiology, diagnosis, and management. NPJ Parkinsons Dis 8(1):31 + + 10.1038/s41531-022-00295-x + 35332158 + 8948218 + + + + +
+ + + 36809490 + + 2023 + 02 + 22 + +
+ + 1573-3254 + + + 2023 + Feb + 21 + + + AIDS and behavior + AIDS Behav + + Use of Stated Preference Methods in HIV Treatment and Prevention Research in the United States: A Systematic Review. + 10.1007/s10461-022-03962-5 + + Stated preference (SP) methods are increasingly being applied to HIV-related research and continuously provide researchers with health utility scores of select healthcare products or services that populations consider important. Following PRISMA guidelines, we sought to understand how SP methods have been applied in HIV-related research. We conducted a systematic review to identify studies meeting the following criteria: SP method is clearly stated, conducted in the United States, was published between 01/01/2012 and 02/12/2022, and included adults aged 18 and over. Study design and SP method application were also examined. We identified six SP methods (e.g., Conjoint Analysis, Discrete Choice Experiment) across 18 studies, which were categorized into one of two groups: HIV prevention and HIV treatment-care. Categories of attributes used in SP methods largely focused on: administration, physical/health effects, financial, location, access, and external influences. SP methods are innovative tools capable of informing researchers on what populations consider most beneficial when deciding on treatment, care, or prevention options for HIV. + © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. + + + + Rodriguez + Christofer A + CA + http://orcid.org/0000-0002-5259-7684 + + Department of Health Promotion and Disease Prevention, Robert Stempel College of Public Health and Social Work, Florida International University, 11200 SW 8th St, AHC-5 Ste. 405, Miami, FL, 33199, USA. Crodr738@fiu.edu. + + + + Mitchell + Jason W + JW + + Department of Health Promotion and Disease Prevention, Robert Stempel College of Public Health and Social Work, Florida International University, 11200 SW 8th St, AHC-5 Ste. 405, Miami, FL, 33199, USA. + + + + eng + + Journal Article + Review + + + 2023 + 02 + 21 + +
+ + United States + AIDS Behav + 9712133 + 1090-7165 + + IM + + Elicit preferences + HIV prevention + HIV treatment and care + Stated preference methods + +
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+ + + 36809487 + + 2023 + 02 + 22 + +
+ + 1936-0541 + + + 2023 + Feb + 21 + + + Hepatology international + Hepatol Int + + Association of MAFLD with end-stage kidney disease: a prospective study of 337,783 UK Biobank participants. + 10.1007/s12072-023-10486-0 + + Metabolic dysfunction-associated fatty liver (MAFLD) has been found to be associated with the prevalence of chronic kidney disease (CKD). However, it is unknown whether MAFLD is associated with CKD development and the incidence of end-stage kidney disease (ESKD). We aimed to clarify the association between MAFLD and incident ESKD in the prospective UK Biobank cohort. + We analyzed the data of 337,783 UK Biobank participants and relative risks for the ESKD were calculated by using the Cox regression analysis. + Among 337,783 participants over a median duration of 12.8 years follow-up, a total of 618 ESKD cases were diagnosed. Participants with MAFLD were twice likely to develop ESKD (hazard ratio [HR] 2.03, 95% confidence interval [CI] 1.68-2.46, p < 0.001). The association of MAFLD with ESKD risk remained significant in both non-CKD and CKD participants. Our results also showed that there were graded associations between liver fibrosis scores and the risk of ESKD in MAFLD cases. Compared to non-MAFLD individuals, the adjusted HRs for incident ESKD in MAFLD patients with increasing levels of NAFLD fibrosis score were 1.23 (95% CI 0.96-1.58), 2.45 (1.98-3.03) and 7.67 (5.48-10.73), respectively. Furthermore, the risking alleles of PNPLA3 rs738409, TM6SF2 rs58542926, GCKR rs1260326 and MBOAT7 rs641738 amplified the MAFLD effect on ESKD risk. In conclusion, MAFLD is associated with incident ESKD. + MAFLD may help identify the subjects at high risk of ESKD development and MAFLD interventions should be encouraged to slow down CKD progression. + © 2023. Asian Pacific Association for the Study of the Liver. + + + + Chen + Shen + S + + Department of Toxicology, School of Public Health, Sun Yat-Sen University, Guangzhou, People's Republic of China. + + + + Pang + Juan + J + + Department of Nutrition, School of Public Health, Sun Yat-Sen University (Northern Campus), No.74, 2nd Zhongshan Road, Guangzhou, 510080, People's Republic of China. + + + + Huang + Rong + R + + Medical Science and Technology Innovation Center, Jinan Central Hospital, Shandong First Medical University, Taian, Jinan, China. + + + + Xue + Hongliang + H + + Department of Nutrition, School of Public Health, Guangzhou Medical University, 195 Dongfeng W Rd., Guangzhou, 510080, People's Republic of China. rossxue666@gmail.com. + + + + Chen + Xu + X + http://orcid.org/0000-0003-4735-2364 + + Department of Nutrition, School of Public Health, Sun Yat-Sen University (Northern Campus), No.74, 2nd Zhongshan Road, Guangzhou, 510080, People's Republic of China. cxu1024@gmail.com. + + + Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, USA. cxu1024@gmail.com. + + + + eng + + + 82103823 + National Natural Science Foundation of China + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Hepatol Int + 101304009 + 1936-0533 + + IM + + End-stage kidney disease + Liver fibrosis scores + MAFLD + Polygenic risk score + UK Biobank + +
+ + + + 2022 + 11 + 06 + + + 2023 + 01 + 12 + + + 2023 + 2 + 22 + 13 + 50 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809487 + 10.1007/s12072-023-10486-0 + 10.1007/s12072-023-10486-0 + + + + Crews DC, Bello AK, Saadi G, for the World Kidney Day Steering C. Burden, access, and disparities in kidney disease. Am J Nephrol. 2019;49:254–262 + + 30820003 + 10.1159/000497540 + + + + Babickova J, Klinkhammer BM, Buhl EM, Djudjaj S, Hoss M, Heymann F, et al. Regardless of etiology, progressive renal disease causes ultrastructural and functional alterations of peritubular capillaries. Kidney Int. 2017;91:70–85 + + 27678159 + 10.1016/j.kint.2016.07.038 + + + + Ruiz-Ortega M, Rayego-Mateos S, Lamas S, Ortiz A, Rodrigues-Diez RR. Targeting the progression of chronic kidney disease. Nat Rev Nephrol. 2020;16:269–288 + + 32060481 + 10.1038/s41581-019-0248-y + + + + Cockwell P, Fisher LA. The global burden of chronic kidney disease. 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Metabolism. 2021;124: 154874 + + 34517014 + 10.1016/j.metabol.2021.154874 + + + + +
+ + + 36809489 + + 2023 + 02 + 22 + +
+ + 1523-5866 + + + 2023 + Feb + 21 + + + Neuro-oncology + Neuro Oncol + + Cognitive outcomes after multimodal treatment in adult glioma patients: A meta-analysis. + noad045 + 10.1093/neuonc/noad045 + + Cognitive functioning is increasingly assessed as a secondary outcome in neuro-oncological trials. However, which cognitive domains or tests to assess, remains debatable. In this meta-analysis, we aimed to elucidate the longer-term test-specific cognitive outcomes in adult glioma patients. + A systematic search yielded 7098 articles for screening. To investigate cognitive changes in glioma patients and differences between patients and controls ≥one-year follow-up, random-effects meta-analyses were conducted per cognitive test, separately for studies with a longitudinal and cross-sectional design. A meta-regression analysis with a moderator for interval testing (additional cognitive testing between baseline and one-year post-treatment) was performed to investigate the impact of practice in longitudinal designs. + Eighty-three studies were reviewed, of which 37 were analyzed in the meta-analysis, involving 4078 patients. In longitudinal designs, semantic fluency was the most sensitive test to detect cognitive decline over time. Cognitive performance on MMSE, digit span forward, phonemic and semantic fluency declined over time in patients who had no interval testing. In cross-sectional studies, patients performed worse than controls on the MMSE, digit span backward, semantic fluency, Stroop speed interference task, trail making test B and finger tapping. + Cognitive performance of glioma patients one year after treatment is significantly lower compared to the norm, with specific tests potentially being more sensitive. Cognitive decline over time occurs as well, but can easily be overlooked in longitudinal designs due to practice effects (as a result of interval testing). It is warranted to sufficiently correct for practice effects in future longitudinal trials. + © The Author(s) 2023. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. + + + + De Roeck + Laurien + L + 0000-0002-2571-1816 + + Department of Oncology, KU Leuven, Leuven, Belgium. + + + Department of Radiation Oncology, University Hospitals Leuven, Leuven, Belgium. + + + + Gillebert + R Céline + RC + + Department of Brain and Cognition, Leuven Brain Institute (LBI), KU Leuven, Belgium. + + + Centre for Translational Psychological Research (TRACE), Hospital East-Limbourg, Genk, Belgium. + + + + van Aert + Robbie C M + RCM + 0000-0001-6187-0665 + + Department of Methodology and Statistics, Tilburg University, Tilburg, the Netherlands. + + + + Vanmeenen + Amber + A + + Department of Brain and Cognition, Leuven Brain Institute (LBI), KU Leuven, Belgium. + + + + Klein + Martin + M + 0000-0001-5553-7911 + + Department of Medical Psychology, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. + + + + Taphoorn + Martin J B + MJB + 0000-0001-9949-4722 + + Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands. + + + Haaglanden Medical Center, The Hague, The Netherlands. + + + + Gehring + Karin + K + + Department of Neurosurgery, Elisabeth-TweeSteden Hospital, Tilburg, the Netherlands. + + + Department of Cognitive Neuropsychology, Tilburg University, Tilburg, the Netherlands. + + + + Lambrecht + Maarten + M + 0000-0002-8746-2691 + + Department of Oncology, KU Leuven, Leuven, Belgium. + + + Department of Radiation Oncology, University Hospitals Leuven, Leuven, Belgium. + + + + Sleurs + Charlotte + C + 0000-0002-4480-8330 + + Department of Oncology, KU Leuven, Leuven, Belgium. + + + Department of Neurosurgery, Elisabeth-TweeSteden Hospital, Tilburg, the Netherlands. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Neuro Oncol + 100887420 + 1522-8517 + + IM + + Adult + Cognition + Cognitive evaluation + Glioma + Meta-analysis + +
+ + + + 2022 + 08 + 19 + + + 2023 + 2 + 22 + 13 + 50 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809489 + 7049761 + 10.1093/neuonc/noad045 + + +
+ + + 36809492 + + 2023 + 02 + 22 + +
+ + 1880-4233 + + + 2023 + Feb + 21 + + + Breast cancer (Tokyo, Japan) + Breast Cancer + + Severity and risk factors of interval breast cancer in Queensland, Australia: a population-based study. + 10.1007/s12282-023-01439-4 + + Interval breast cancers (BC) are those diagnosed within 24 months of a negative mammogram. This study estimates the odds of being diagnosed with high-severity BC among screen-detected, interval, and other symptom-detected BC (no screening history within 2 years); and explores factors associated with being diagnosed with interval BC. + Telephone interviews and self-administered questionnaires were conducted among women (n = 3,326) diagnosed with BC in 2010-2013 in Queensland. Respondents were categorised into screen-detected, interval, and other symptom-detected BCs. Data were analysed using logistic regressions with multiple imputation. + Compared with screen-detected BC, interval BC had higher odds of late-stage (OR = 3.50, 2.9-4.3), high-grade (OR = 2.36, 1.9-2.9) and triple-negative cancers (OR = 2.55, 1.9-3.5). Compared with other symptom-detected BC, interval BC had lower odds of late stage (OR = 0.75, 0.6-0.9), but higher odds of triple-negative cancers (OR = 1.68, 1.2-2.3). Among women who had a negative mammogram (n = 2,145), 69.8% were diagnosed at their next mammogram, while 30.2% were diagnosed with an interval cancer. Those with an interval cancer were more likely to have healthy weight (OR = 1.37, 1.1-1.7), received hormone replacement therapy (2-10 years: OR = 1.33, 1.0-1.7; > 10 years: OR = 1.55, 1.1-2.2), conducted monthly breast self-examinations (BSE) (OR = 1.66, 1.2-2.3) and had previous mammogram in a public facility (OR = 1.52, 1.2-2.0). + These results highlight the benefits of screening even among those with an interval cancer. Women-conducted BSE were more likely to have interval BC which may reflect their increased ability to notice symptoms between screening intervals. + © 2023. The Author(s). + + + + Kou + Kou + K + + Cancer Council Queensland, Spring Hill, PO Box 201, Brisbane, QLD, 4001, Australia. + + + + Cameron + Jessica + J + + Cancer Council Queensland, Spring Hill, PO Box 201, Brisbane, QLD, 4001, Australia. + + + School of Mathematical Sciences, Queensland University of Technology, Brisbane, Australia. + + + + Youl + Philippa + P + + Cancer Alliance Queensland, Metro South Hospital and Health Service, Woolloongabba, Australia. + + + + Pyke + Chris + C + + Mater Hospitals South Brisbane, Brisbane, Australia. + + + + Chambers + Suzanne + S + + Faculty of Health, University of Technology Sydney, Sydney, Australia. + + + + Dunn + Jeff + J + + Prostate Cancer Foundation of Australia, Sydney, Australia. + + + + Aitken + Joanne F + JF + + Cancer Council Queensland, Spring Hill, PO Box 201, Brisbane, QLD, 4001, Australia. + + + School of Public Health, The University of Queensland, Brisbane, Australia. + + + School of Public Health and Social Work, Queensland University of Technology, Brisbane, Australia. + + + Institute for Resilient Regions, University of Southern Queensland, Brisbane, Australia. + + + + Baade + Peter D + PD + http://orcid.org/0000-0001-8576-8868 + + Cancer Council Queensland, Spring Hill, PO Box 201, Brisbane, QLD, 4001, Australia. peter.baade@qut.edu.au. + + + Centre for Data Science, Faculty of Science, Queensland University of Technology, Brisbane, Australia. peter.baade@qut.edu.au. + + + Menzies Health Institute Queensland, Griffith University, Gold Coast Campus, Parklands Drive, Southport, QLD, Australia. peter.baade@qut.edu.au. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Japan + Breast Cancer + 100888201 + 1340-6868 + + IM + + Breast cancer + Interval cancer + Mammogram screening + Risk factors + Severity + +
+ + + + 2022 + 10 + 18 + + + 2023 + 02 + 15 + + + 2023 + 2 + 22 + 13 + 50 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809492 + 10.1007/s12282-023-01439-4 + 10.1007/s12282-023-01439-4 + + + + Youl PH, Baade PD, Aitken JF, Chambers SK, Turrell G, Pyke C, et al. A multilevel investigation of inequalities in clinical and psychosocial outcomes for women after breast cancer. BMC Cancer. 2011;11:415. + + 10.1186/1471-2407-11-415 + 21951320 + 3195770 + + + + Gilliland FD, Joste N, Stauber PM, Hunt WC, Rosenberg R, Redlich G, et al. Biologic characteristics of interval and screen-detected breast cancers. J Natl Cancer Inst. 2000;92:743–9. + + 10.1093/jnci/92.9.743 + 10793111 + + + + Rayson D, Payne JI, Abdolell M, Barnes PJ, MacIntosh RF, Foley T, et al. Comparison of clinical-pathologic characteristics and outcomes of true interval and screen-detected invasive breast cancer among participants of a Canadian breast screening program: a nested case-control study. Clin Breast Cancer. 2011;11:27–32. + + 10.3816/CBC.2011.n.005 + 21421519 + + + + Krishnan K, Baglietto L, Apicella C, Stone J, Southey MC, English DR, et al. Mammographic density and risk of breast cancer by mode of detection and tumor size: a case-control study. Breast Cancer Res. 2016;18:1–13. + + 10.1186/s13058-016-0722-4 + + + + Cheasley D, Li N, Rowley SM, Elder K, Mann GB, Loi S, et al. Molecular comparison of interval and screen-detected breast cancers. J Pathol. 2019;248:243–52. + + 10.1002/path.5251 + 30746706 + + + + Kirsh VA, Chiarelli AM, Edwards SA, O’Malley FP, Shumak RS, Yaffe MJ, et al. Tumor characteristics associated with mammographic detection of breast cancer in the Ontario breast screening program. 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+ + 1432-1432 + + + 2023 + Feb + 21 + + + Journal of molecular evolution + J Mol Evol + + Non-random Codon Usage of Synonymous and Non-synonymous Mutations in the Human HLA-A Gene. + 10.1007/s00239-023-10093-5 + + The structure and function of human leucocyte antigen (HLA-A) is well known and is an extremely variable protein. From the public HLA-A database, we chose 26 high frequency HLA-A alleles (45% of sequenced alleles). Using five arbitrary references from these alleles, we analyzed synonymous mutations at the third codon position (sSNP3) and non-synonymous mutations (NSM). Both mutation types showed non-random locations of 29 sSNP3 codons and 71 NSM codons in the five reference lists. Most sSNP3 codons show identical mutation types with many mutations resulting from cytosine deamination. We proposed 23 ancestral parents of sSNP3 in five reference sequences using conserved parents in five unidirectional codons and 18 majority parents in reciprocal codons. These 23 proposed ancestral parents show exclusive codon usage of G3 or C3 parents located on both DNA strands that mutate to A3 or T3 variants mostly (76%) by cytosine deamination The sSNP3 and NSM show clear separation of the two variant types with most sSNP3 located in conserved areas in exons 2, 3 and 4, compared to most NSM appearing in two Variable Areas with no sSNP3 in the latter parts of exons 2 (α1) and 3 (α2). The Variable Areas contain NSM (polymorphic) residues at the center of the groove that bind the foreign peptide. We find distinctly different mutation patterns in NSM codons from those of sSNP3. Namely, G-C to A-T mutation frequency was much smaller, suggesting that evolutional pressures of deamination and other mechanisms applied to the two areas are significantly different. + © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. + + + + Matsushita + Tatsuo + T + http://orcid.org/0000-0003-3711-2623 + + , 1508 Fuqua Drive, Fort Collins, CO, 80521, USA. tatsym@yahoo.com. + + + + Kano-Sueoka + Tamiko + T + + Molecular Cellular and Developmental Biology, University of Colorado Boulder, Boulder, CO, 80309, USA. + + + , 4036 Germainder Way, Irvine, CA, 92612-2106, USA. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
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+ + 1869-6953 + + + 2023 + Feb + 21 + + + Diabetes therapy : research, treatment and education of diabetes and related disorders + Diabetes Ther + + Impact of Type 2 Diabetes Duration on the Efficacy and Safety of Add-on Lixisenatide in Asian Individuals Receiving Basal Insulin: A Pooled Analysis. + 10.1007/s13300-023-01369-6 + + This analysis investigated the efficacy and safety of add-on lixisenatide by disease duration in Asian people with type 2 diabetes inadequately controlled with basal insulin ± oral antidiabetic drugs. + Data for Asian participants in the GetGoal-Duo 1, GetGoal-L, and GetGoal-L-C studies were pooled and categorized by diabetes duration: < 10 years (group 1), 10 to < 15 years (group 2), and ≥ 15 years (group 3). Efficacy and safety of lixisenatide versus placebo were evaluated by subgroup. The potential influence of diabetes duration on efficacy was examined using multivariable regression analyses. + A total of 555 participants were included (mean age 53.9 years, 52.4% male). No significant differences in treatment effect between the duration subgroups were observed for the changes from baseline to 24 weeks in glycated hemoglobin (HbA1c), fasting plasma glucose (FPG), postprandial glucose (PPG), PPG excursion, body weight or body mass index, or the proportion of participants with HbA1c < 7% at 24 weeks (all P values for interaction > 0.1). Change in insulin dosage (U/day) was significantly different between subgroups (P = 0.038). Multivariable regression analysis showed participants in group 1 had a smaller change in body weight and basal insulin dose over the 24-week treatment period than participants in group 3 (P = 0.014 and 0.030, respectively) and were less likely to achieve an HbA1c < 7% than participants in group 2 (P = 0.047). No severe hypoglycemia was reported. A higher proportion of participants in group 3 versus the other groups had symptomatic hypoglycemia, for both lixisenatide and placebo, and T2D duration had a significant effect on hypoglycemia risk (P = 0.001). + Lixisenatide improved glycemic control in Asian individuals regardless of diabetes duration, without increasing the risk of hypoglycemia. Individuals with longer disease duration had a greater risk of symptomatic hypoglycemia than individuals with shorter disease duration regardless of treatment. No additional safety concerns were observed. + GetGoal-Duo 1, ClinicalTrials.gov record NCT00975286; GetGoal-L, ClinicalTrials.gov record NCT00715624; GetGoal-L-C, ClinicalTrials.gov record NCT01632163. + © 2023. The Author(s). + + + + Yao + Jun + J + + Department of Endocrinology, Peking University First Hospital, Nov. 8 Xishiku Street, West City District, Beijing, 100034, China. + + + + Zhang + Minlu + M + + Sanofi, Shanghai, China. + + + + Zhang + Xia + X + + Sanofi, Shanghai, China. + + + + Zhang + Junqing + J + + Department of Endocrinology, Peking University First Hospital, Nov. 8 Xishiku Street, West City District, Beijing, 100034, China. junqing.zhang@pkufh.cn. + + + + eng + + + ClinicalTrials.gov + + NCT00975286 + NCT00715624 + NCT01632163 + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Diabetes Ther + 101539025 + 1869-6961 + + + Disease duration + Glucagon-like peptide 1 receptor agonist + Lixisenatide + Pooled analysis + Type 2 diabetes + +
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+ + + 36809500 + + 2023 + 02 + 22 + +
+ + 1672-0415 + + + 2023 + Feb + 21 + + + Chinese journal of integrative medicine + Chin J Integr Med + + Challenges and Perspectives in Target Identification and Mechanism Illustration for Chinese Medicine. + 10.1007/s11655-023-3629-9 + + Chinese medicine (CM) is an important resource for human life understanding and discovery of drugs. However, due to the unclear pharmacological mechanism caused by unclear target, research and international promotion of many active components have made little progress in the past decades of years. CM is mainly composed of multi-ingredients with multi-targets. The identification of targets of multiple active components and the weight analysis of multiple targets in a specific pathological environment, that is, the determination of the most important target is the main obstacle to the mechanism clarification and thus hinders its internationalization. In this review, the main approach to target identification and network pharmacology were summarized. And BIBm (Bayesian inference modeling), a powerful method for drug target identification and key pathway determination was introduced. We aim to provide a new scientific basis and ideas for the development and international promotion of new drugs based on CM. + © 2023. The Chinese Journal of Integrated Traditional and Western Medicine Press and Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Guo + Xiao-Xi + XX + + Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, China. + + + + An + Su + S + + Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, China. + + + + Bao + Fan + F + + Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, China. + + + The First People's Hospital of Yunnan Province, Kunming, 650032, China. + + + + Xu + Tian-Rui + TR + + Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, China. tianruixu@kust.edu.cn. + + + + eng + + Journal Article + Review + + + 2023 + 02 + 21 + +
+ + China + Chin J Integr Med + 101181180 + 1672-0415 + + IM + + Bayesian inference modeling + Chinese medicine + network pharmacology + target identification + +
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Drug Des Devel Ther 2019;13:2997–3007. + + 31692519 + 6710481 + 10.2147/DDDT.S207823 + + + + +
+ + + 36809497 + + 2023 + 02 + 22 + +
+ + 1573-6695 + + + 2023 + Feb + 21 + + + Prevention science : the official journal of the Society for Prevention Research + Prev Sci + + Sticking with Programs That Do Not Work: The Role of Escalation of Commitment in Schools. + 10.1007/s11121-023-01510-8 + + Schools are the most common site to implement evidence-based prevention programs and practices (EBPs) to improve behavioral and mental health outcomes among children and adolescents. Research has highlighted the critical role of school administrators in the adoption, implementation, and evaluation of such EBPs, focusing on the factors they should consider during the adoption decision and the behaviors needed for successful implementation. However, scholars have only recently begun to focus on the de-adoption or de-implementation of low-value programs and practices to make room for evidence-based alternatives. This study introduces escalation of commitment as a theoretical framework for understanding why school administrators may stick with ineffective programs and practices. Escalation of commitment is a robust decision-making bias in which people feel compelled to continue with a course of action even when performance indicators suggest it is not going well. Using grounded theory methodology, we conducted semi-structured interviews with 24 building- and district-level school administrators in the Midwestern United States. Results suggested that escalation of commitment occurs when administrators attribute the underlying causes of poor program performance not to the program itself but instead to issues related to implementation, leadership, or the limitations of the performance indicators themselves. We also identified a variety of psychological, organizational, and external determinants that accentuate administrators' continuance of ineffective prevention programs. Based on our findings, we highlight several contributions to theory and practice. + © 2023. Society for Prevention Research. + + + + Barrett + Courtenay A + CA + http://orcid.org/0000-0001-9258-4725 + + Michigan State University, East Lansing, USA. morsicou@msu.edu. + + + + Sleesman + Dustin J + DJ + + University of Delaware, Newark, USA. + + + + Spear + Shelbie E + SE + + Michigan State University, East Lansing, USA. + + + + Clinkscales + Andryce + A + + Michigan State University, East Lansing, USA. + + + + Amin + Tazkira + T + + Michigan State University, East Lansing, USA. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Prev Sci + 100894724 + 1389-4986 + + IM + + Adoption + De-adoption + De-implementation + Escalation of commitment + Implementation science + Strategic abandonment + +
+ + + + 2023 + 02 + 09 + + + 2023 + 2 + 22 + 13 + 50 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809497 + 10.1007/s11121-023-01510-8 + 10.1007/s11121-023-01510-8 + + + + Aarons, G. A., Ehrhart, M. G., Farahnak, L. R., & Sklar, M. (2014). Aligning leadership across systems and organizations to develop a strategic climate for evidence-based practice implementation. Annual Review of Public Health, 35, 255–274. + + 10.1146/annurev-publhealth-032013-182447 + 24641560 + 4348088 + + + + Aarons, G. A., Ehrhart, M. G., Moullin, J. C., Torres, E. L., & Green, A. E. (2017). Testing the leadership and organizational change for implementation (LOCI) intervention in substance abuse treatment: a cluster randomized trial study protocol. Implementation Science, 12(1), 29. PMCID: PMC5335741. + + 10.1186/s13012-017-0562-3 + 28253900 + 5335741 + + + + Arkes, H. R., & Blumer, C. (1985). The psychology of sunk cost. 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SAGE Publications Ltd. https://doi.org/10.4135/9781446282243.n11 + + 10.4135/9781446282243.n11 + + + + Van Oorschot, K. E., Akkermans, H., Sengupta, K., & Van Wassenhove, L. N. (2013). Anatomy of a decision trap in complex new product development projects. Academy of Management Journal, 56(1), 285–307. https://doi.org/10.5465/amj.2010.0742 + + 10.5465/amj.2010.0742 + + + + Vasileiou, K., Barnett, J., Thorpe, S., & Young, T. (2018). Characterizing and justifying sample size sufficiency ininterview-based studies: systematic analysis of qualitative health researchover a 15-year period. BMC Medical Research Methodology, 18(1), 148. + + 10.1186/s12874-018-0594-7 + 30463515 + 6249736 + + + + +
+ + + 36809499 + + 2023 + 02 + 22 + +
+ + 1672-0415 + + + 2023 + Feb + 21 + + + Chinese journal of integrative medicine + Chin J Integr Med + + Effects of Zishen Yutai Pills on in vitro Fertilization-Embryo Transfer Outcomes in Patients with Diminished Ovarian Reserve: A Prospective, Open-Labeled, Randomized and Controlled Study. + 10.1007/s11655-023-3546-y + + To explore the effects of Zishen Yutai Pills (ZYPs) on the quality of oocytes and embryos, as well as pregnancy outcomes in patients with diminished ovarian reserve (DOR) receiving in vitro fertilization-embryo transfer (IVF-ET). The possible mechanisms, involving the regulation of bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9), were also investigated. + A total of 120 patients with DOR who underwent their IVF-ET cycle were randomly allocated to 2 groups in a 1:1 ratio. The patients in the treatment group (60 cases) received ZYPs from the mid-luteal phase of the former menstrual cycle by using gonadotropin-releasing hormone (GnRH) antagonist protocol. The patients in the control group (60 cases) received the same protocol but without ZYPs. The primary outcomes were the number of oocytes retrieved and high-quality embryos. Secondary outcomes included other oocyte or embryo indices as well as pregnancy outcomes. Adverse events were assessed by comparison of the incidence of ectopic pregnancy, pregnancy complications, pregnancy loss, and preterm birth. Contents of BMP15 and GDF9 in the follicle fluids (FF) were also quantified with enzyme-linked immunosorbent assay. + Compared with the control group, the numbers of oocytes retrieved and high-quality embryos were significantly increased in the ZYPs group (both P<0.05). After treatment with ZYPs, a significant regulation of serum sex hormones was observed, including progesterone and estradiol. Both hormones were up-regulated compared with the control group (P=0.014 and 0.008), respectively. No significant differences were observed with regard to pregnancy outcomes including implantation rates, biochemical pregnancy rates, clinical pregnancy rates, live birth rates, and pregnancy loss rates (all P>0.05). The administration of ZYPs did not increase the incidence of adverse events. The expressions of BMP15 and GDF9 in the ZYPs group were significantly up-regulated compared with the control group (both P<0.05). + ZYPs exhibited beneficial effects in DOR patients undergoing IVF-ET, resulting in increments of oocytes and embryos, and up-regulation of BMP15 and GDF9 expressions in the FF. However, the effects of ZYPs on pregnancy outcomes should be assessed in clinical trials with larger sample sizes (Trial reqistration No. ChiCTR2100048441). + © 2023. The Chinese Journal of Integrated Traditional and Western Medicine Press and Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Li + Xiu-Fang + XF + + The First Clinical College, Shandong University of Traditional Chinese Medicine, Jinan, 250014, China. + + + Center for Reproductive Medicine, Shandong University, Jinan, 250021, China. + + + + Wang + Zhong-Qing + ZQ + + Medical College of Optometry and Ophthalmology, Shandong University of Traditional Chinese Medicine, Jinan, 250014, China. + + + Department of Traditional Chinese Medicine, Jinan Golden Time Health Nursing Hospital, Jinan, 250000, China. + + + + Xu + Hai-Yan + HY + + Center for Reproductive Medicine, Shandong University, Jinan, 250021, China. + + + + Liu + Hong + H + + Center for Reproductive Medicine, Shandong University, Jinan, 250021, China. + + + + Sheng + Yan + Y + + Center for Reproductive Medicine, Shandong University, Jinan, 250021, China. + + + + Xu + Jin + J + + Center for Reproductive Medicine, Shandong University, Jinan, 250021, China. + + + + Li + Yuan-Mei + YM + + Center for Reproductive Medicine, Shandong University, Jinan, 250021, China. + + + + Lian + Fang + F + + Reproductive and Genetic Center of Integrated Traditional and Western Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250011, China. fang_lian123@163.com. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + China + Chin J Integr Med + 101181180 + 1672-0415 + + IM + + Zishen Yutai Pills + diminished ovarian reserve + embryos + in vitro fertilization-embryo transfer + oocytes + +
+ + + + 2022 + 12 + 06 + + + 2023 + 2 + 22 + 13 + 50 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809499 + 10.1007/s11655-023-3546-y + 10.1007/s11655-023-3546-y + + + + Cedars MI. Managing poor ovarian response in the patient with diminished ovarian reserve. Fertil Steril 2022;117:655–656. + + 10.1016/j.fertnstert.2022.02.026 + 35367010 + + + + Levi AJ, Raynault MF, Bergh PA, Drews MR, Miller BT, Scott RT. Reproductive outcome in patients with diminished ovarian reserve. Fertil Steril 2001;76:666–669. + + 10.1016/S0015-0282(01)02017-9 + 11591396 + + + + Merhi Z, Zapantis A, Berger DS, Jindal SK. Determining an anti-mullerian hormone cutoff level to predict clinical pregnancy following in vitro fertilization in women with severely diminished ovarian reserve. J Assist Reprod Genet 2013;30:1361–1365. + + 10.1007/s10815-013-0077-z + 23963620 + 3824854 + + + + Ferraretti AP, La Marca A, Fauser BCJM, Tarlatzis B, Nargund G, Gianaroli L. 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+ + + 36809496 + + 2023 + 02 + 22 + +
+ + 1433-7339 + + 31 + 3 + + 2023 + Feb + 21 + + + Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer + Support Care Cancer + + Radiotherapy and palliative care outpatient clinic: a new healthcare integrated model in Italy. + + 174 + + 10.1007/s00520-023-07584-y + + On the basis of substantial evidence demonstrate that palliative care combined with standard care improves patient, caregiver, and society outcomes, we have developed a new healthcare model called radiotherapy and palliative care (RaP) outpatient clinic were a radiation oncologist and a palliative care physician make a joint evaluation of advanced cancer patients. + We performed a monocentric observational cohort study on advanced cancer patients referred for evaluation at the RaP outpatient clinic. Measures of quality of care were carried out. + Between April 2016 and April 2018, 287 joint evaluations were performed and 260 patients were evaluated. The primary tumor was lung in 31.9% of cases. One hundred fifty (52.3%) evaluations resulted in an indication for palliative radiotherapy treatment. In 57.6% of cases was used a single dose fraction of radiotherapy (8 Gy). All the irradiated cohort completed the palliative radiotherapy treatment. An 8% of irradiated patients received the palliative radiotherapy treatment in the last 30 days of life. A total of 80% of RaP patients received palliative care assistance until the end of life. + At the first descriptive analysis, the radiotherapy and palliative care model seem to respond to the need of multidisciplinary approach in order to obtain an improvement on quality of care for advanced cancer patients. + © 2023. The Author(s). + + + + Rossi + Romina + R + + Palliative Care Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy. romina.rossi@irst.emr.it. + + + + Foca + Flavia + F + + Unit of Biostatistics and Clinical Trials, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy. + + + + Tontini + Luca + L + + Radiotherapy Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy. + + + + Pieri + Martina + M + + Radiotherapy Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy. + + + + Micheletti + Simona + S + + Radiotherapy Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy. + + + + Nanni + Oriana + O + + Unit of Biostatistics and Clinical Trials, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy. + + + + Altini + Mattia + M + + Healthcare Administration, Azienda Unità Sanitaria Locale della Romagna, Ravenna, Italy. + + + + Massa + Ilaria + I + + Outcome Research, Healthcare Administration, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "DinoAmadori", Meldola, Italy. + + + + Pallotti + Maria Caterina + MC + + Palliative Care Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy. + + + + Ricci + Marianna + M + + Palliative Care Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy. + + + + Romeo + Antonino + A + + Radiotherapy Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy. + + + + Muolo + Maria Giustina + MG + + Radiotherapy Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy. + + + + Galeotti + Gianluca + G + + Radiotherapy Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy. + + + + Valenti + Vanessa + V + + Palliative Care Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy. + + + + Tenti + Maria Valentina + MV + + Palliative Care Unit, Azienda Unità Sanitaria Locale della Romagna, Forlì, Italy. + + + + Donati + Costanza Maria + CM + + Radiation Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy. + + + Radiation Oncology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy. + + + + Pensieri + Maria Vittoria + MV + + Medical Oncology, "San Salvatore" Hospital, Univerity of L'Aquila, L'Aquila, Italy. + + + Department of Biotechnological and Applied Clinical Sciences, Univerity of L'Aquila, L'Aquila, Italy. + + + + Morganti + Alessio Giuseppe + AG + + Radiation Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy. + + + Radiation Oncology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy. + + + + Maltoni + Marco + M + + Medical Oncology Unit, Department of Specialized, Experimental and Diagnostic Medicine (DIMES), University of Bologna, Bologna, Italy. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Support Care Cancer + 9302957 + 0941-4355 + + IM + + Aggressiveness of care + Palliative care + Palliative radiotherapy + Symptom management + +
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Future Oncol 11:2417–2426. https://doi.org/10.2217/FON.15.15 + + 10.2217/FON.15.15 + 26271002 + + + + Lefresne S, Berthelet E, Cashman R, Levy K, Liu M, Carolan H, McKenzie M, Kostuik P, Olson R (2015) The Vancouver rapid access clinic for palliative lung radiation, providing more than just rapid access. Support Care Cancer 23:125–132. https://doi.org/10.1007/s00520-014-2345-6 + + 10.1007/s00520-014-2345-6 + 25001608 + + + + Pituskin E, Fairchild A, Dutka J, Gagnon L, Driga A, Tachynski P, Borschneck JA, Ghosh S (2010) Multidisciplinary team contributions within a dedicated outpatient palliative radiotherapy clinic: a prospective descriptive study. Int J Radiat Oncol Biol Phys 78:527–532. https://doi.org/10.1016/j.ijrobp.2009.07 + + 10.1016/j.ijrobp.2009.07 + 20100640 + + + + Pulenzas N, Lechner B, Zhang L, Thavarajah N, Wong E, Lauzon N, Holden L, Sheehan P, Bedard G, McDonald R, Bain E, Tsao M, Barnes E, Danjoux C, Chow E (2014) The incidence of DNR documentation in patients referred for palliative radiotherapy in the Rapid Response Radiotherapy Program. J Palliat Med 17:1296–1297. https://doi.org/10.1089/jpm.2014.0322 + + 10.1089/jpm.2014.0322 + 25383944 + + + + Gorman D, Balboni T, Taylor A, Krishnan M (2015) The supportive and palliative radiation oncology service: a dedicated model for palliative radiation oncology care. J Adv Pract Oncol 6:135–140. https://doi.org/10.6004/jadpro.2015.6.2.5 + + 10.6004/jadpro.2015.6.2.5 + 26649246 + 4601893 + + + + Appropriateness in radiation oncology: indications and considerations by Italian Association of Radiotherapy Oncology (AIRO). 1–17, 2012. Available at: https://www.radioterapiaitalia.it/?L&ID=703&CERCA=appropriatezza#703 [Accessed 20th May, 2022]. + + + Recommendation from AIRO—choosing wisely Italy. Available at: https://choosingwiselyitaly.org [Accessed 20th May, 2022]. + + + Temel JS, Greer JA, Muzikansky A, Gallagher ER, Admane S, Jackson VA, Dahlin CM, Blinderman CD, Jacobsen J, Pirl WF, Billings JA, Lynch TJ (2010) Early palliative care for patients with metastatic non-small-cell lung cancer. N Engl J Med 363:733–742. https://doi.org/10.1056/NEJMoa1000678 + + 10.1056/NEJMoa1000678 + 20818875 + + + + Maltoni M, Scarpi E, Dall’Agata M, Zagonel V, Bertè R, Ferrari D, Broglia CM, Bortolussi R, Trentin L, Valgiusti M, Pini S, Farolfi A, Casadei Gardini A, Nanni O, Amadori D; Early Palliative Care Italian Study Group (EPCISG) (2016) Systematic versus on-demand early palliative care: results from a multicentre, randomised clinical trial. Eur J Cancer 65:61–68. https://doi.org/10.1016/j.ejca.2016.06.007 + + 10.1016/j.ejca.2016.06.007 + + + + Maltoni M, Scarpi E, Dall’Agata M, Schiavon S, Biasini C, Codecà C, Broglia CM, Sansoni E, Bortolussi R, Garetto F, Fioretto L, Cattaneo MT, Giacobino A, Luzzani M, Luchena G, Alquati S, Quadrini S, Zagonel V, Cavanna L, Ferrari D, Pedrazzoli P, Frassineti GL, Galiano A, Casadei Gardini A, Monti M, Nanni O; Early Palliative Care Italian Study Group (EPCISG) (2016) Systematic versus on-demand early palliative care: a randomised clinical trial assessing quality of care and treatment aggressiveness near the end of life. Eur J Cancer 69:110–118. https://doi.org/10.1016/j.ejca.2016.10.004 + + 10.1016/j.ejca.2016.10.004 + + + + Ferrell BR, Temel JS, Temin S, Smith TJ (2017) Integration of palliative care into standard oncology care: ASCO clinical practice guideline update summary. 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ESMO Open 3:000372. https://doi.org/10.1136/esmoopen-2018-000372 + + 10.1136/esmoopen-2018-000372 + + + + Elmore SNC, Grover S, Bourque JM, Chopra S, Nyakabau AM, Ntizimira C, Krakauer EL, Balboni TA, Gospodarowicz MK, Rodin D (2019) Global palliative radiotherapy: a framework to improve access in resource-constrained settings. Ann Palliat Med 8:274–284. https://doi.org/10.21037/apm.2019.02.02 + + 10.21037/apm.2019.02.02 + 30823841 + 7050283 + + + + Kaasa S, Loge JH, Aapro M, Albreht T, Anderson R, Bruera E, Brunelli C, Caraceni A, Cervantes A, Currow DC, Deliens L, Fallon M, Gómez-Batiste X, Grotmol KS, Hannon B, Haugen DF, Higginson IJ, Hjermstad MJ, Hui D, Jordan K, Kurita GP, Larkin PJ, Miccinesi G, Nauck F, Pribakovic R, Rodin G, Sjøgren P, Stone P, Zimmermann C, Lundeby T (2018) Integration of oncology and palliative care: a Lancet Oncology Commission. 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+ + + 36809503 + + 2023 + 02 + 22 + +
+ + 1432-1335 + + + 2023 + Feb + 21 + + + Journal of cancer research and clinical oncology + J Cancer Res Clin Oncol + + ePRO symptom follow-up of colorectal cancer patients receiving oxaliplatin-based adjuvant chemotherapy is feasible and enhances the quality of patient care: a prospective multicenter study. + 10.1007/s00432-023-04622-4 + + Electronic (e) patient-reported outcomes (PROs) have been shown to improve the quality of life and survival in chemotherapy treated advanced cancer patients. We hypothesized that multidimensional ePRO centered approach could improve symptom management, streamline patient flow, and optimize the use of healthcare resources. + In this multicenter trial (NCT04081558), colorectal cancer (CRC) patients receiving oxaliplatin-based chemotherapy as adjuvant or in the first- or second-line setting in advanced disease were included in the prospective ePRO cohort, while a comparative retrospective cohort was collected from the same institutes. The investigated tool consisted of a weekly e-symptom questionnaire integrated to an urgency algorithm and laboratory value interface, which generated semi-automated decision support for chemotherapy cycle prescription and individualized symptom management. + Recruitment to the ePRO cohort occurred 1/2019-1/2021 (n = 43). The comparator group (n = 194) consisted of patients treated in the same institutes 1-7/2017. The analysis was limited to adjuvant treated (n = 36 and n = 35). The feasibility of the ePRO follow-up was good with 98% reporting easy usage and 86% improved care, while health care personnel valued the easy use and logical workflow. In the ePRO cohort, 42% needed a phone call before planned chemotherapy cycles, while this was 100% in the retrospective cohort (p = 1.4e-8). Peripheral sensory neuropathy was detected significantly earlier with ePRO followed (p = 1e-5) but did not translate to earlier dose reduction, delays, or unplanned therapy termination compared to the retrospective cohort. + The results suggest that the investigated approach is feasible and streamlines workflow. Earlier symptom detection may improve the quality in cancer care. + © 2023. The Author(s). + + + + Iivanainen + Sanna + S + + Department of Oncology and Radiotherapy, Oulu University Hospital and MRC Oulu, P.B. 22, 90029, Oulu, Finland. + + + + Ravichandra + Ravi + R + + Department of Oncology and Radiotherapy, Vaasa Central Hospital, Vaasa, Finland. + + + + Jekunen + Antti + A + + Department of Oncology and Radiotherapy, Vaasa Central Hospital, Vaasa, Finland. + + + Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland. + + + + Arokoski + Reetta + R + + Kaiku Health Oy, Helsinki, Finland. + + + + Mentu + Santeri + S + + Kaiku Health Oy, Helsinki, Finland. + + + + Lang + Laura + L + + Kaiku Health Oy, Helsinki, Finland. + + + + Ekström + Jussi + J + + Kaiku Health Oy, Helsinki, Finland. + + + + Virtanen + Henri + H + + Kaiku Health Oy, Helsinki, Finland. + + + + Kataja + Vesa + V + + Kaiku Health Oy, Helsinki, Finland. + + + + Koivunen + Jussi P + JP + + Department of Oncology and Radiotherapy, Oulu University Hospital and MRC Oulu, P.B. 22, 90029, Oulu, Finland. jussi.koivunen@ppshp.fi. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + J Cancer Res Clin Oncol + 7902060 + 0171-5216 + + IM + + Adjuvant therapy + Adverse event + CIPN + CRC + Chemotherapy + ePRO + +
+ + + + 2022 + 11 + 09 + + + 2023 + 01 + 27 + + + 2023 + 2 + 22 + 13 + 50 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809503 + 10.1007/s00432-023-04622-4 + 10.1007/s00432-023-04622-4 + + + + Argilés G, Tabernero J, Labianca R et al (2020) ESMO Guidelines Committee. Localised colon cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 10:1291–1305. https://doi.org/10.1016/j.annonc.2020.06.022 + + 10.1016/j.annonc.2020.06.022 + + + + Basch E, Deal AM, Kris MG et al (2015) Symptom monitoring with patient reported outcomes during routine cancer treatment: a randomized controlled trial. J Clin Oncol 34:557–565. https://doi.org/10.1200/JCO.2015.63.0830 + + 10.1200/JCO.2015.63.0830 + 26644527 + 4872028 + + + + Basch E, Deal AM, Dueck AC et al (2017) Overall survival results of a trial assessing patient-reported outcomes for symptom monitoring during routine cancer treatment. 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+ + + 36809501 + + 2023 + 02 + 22 + +
+ + 1432-1335 + + + 2023 + Feb + 21 + + + Journal of cancer research and clinical oncology + J Cancer Res Clin Oncol + + Combination of multiple nucleic acid aptamers for precision detection of tumors based on optical methods. + 10.1007/s00432-023-04646-w + + Nucleic acid aptamers are a novel molecular recognition tool that is functionally similar to antibodies but superior to antibodies in terms of thermal stability, structural modification, preparation, and cost, and therefore hold great promise for molecular detection. However, due to the limitations of a single aptamer in molecular detection, the multiple aptamer combination for bioanalysis has received much attention. Here, we reviewed the progress of tumor precision detection based on the combination of multiple nucleic acid aptamers and optical methods and discussed its challenges and prospects. + The relevant literature in PubMed was collected and reviewed. + The combination of two or more aptamers with modern nanomaterials and analytical methods allows the fabrication of various detection systems for the simultaneous detection of different structural domains of a substance and/or different substances, including soluble tumor markers, tumor cell surface and intracellular markers, circulating tumor cells, and other tumor-related biomolecules, which has great potential for application in efficient and precise tumor detection. + The combination of multiple nucleic acid aptamers provides a new approach for the precise detection of tumors and will play an important role in precision medicine for tumors. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Cai + Dan + D + + Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Jiangxi Institute of Gastroenterology and Hepatology, No 17, Yongwai Zheng Street, Nanchang, 330006, Jiangxi, China. + + + + Chen + Gui-Lin + GL + + Department of Anorectal Surgery, Chinese People's Liberation Army Joint Security Force Hospital No. 908, No 1028, Jinggangshan Avenue, Nanchang, China. + + + + Wang + Ting + T + + Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Jiangxi Institute of Gastroenterology and Hepatology, No 17, Yongwai Zheng Street, Nanchang, 330006, Jiangxi, China. + + + + Zhang + Kun-He + KH + + Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Jiangxi Institute of Gastroenterology and Hepatology, No 17, Yongwai Zheng Street, Nanchang, 330006, Jiangxi, China. khzhang@ncu.edu.cn. + + + + eng + + + 2019BBG70048 + the Science and Technology Program Jiangxi Province + + + + 82160494 + National Natural Science Foundation of China + + + + + Journal Article + Review + + + 2023 + 02 + 21 + +
+ + Germany + J Cancer Res Clin Oncol + 7902060 + 0171-5216 + + IM + + Aptamer + Multiplex detection + Precision medicine + Tumor + Tumor marker + +
+ + + + 2022 + 09 + 02 + + + 2023 + 02 + 09 + + + 2023 + 2 + 22 + 13 + 50 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809501 + 10.1007/s00432-023-04646-w + 10.1007/s00432-023-04646-w + + + + Bates SE (1991) Clinical applications of serum tumor markers. Ann Intern Med 115(8):623–638. https://doi.org/10.7326/0003-4819-115-8-623 + + 10.7326/0003-4819-115-8-623 + 1716430 + + + + Chang X, Zhang C, Lv C et al (2019) Construction of a multiple-aptamer-based DNA logic device on live cell membranes via associative toehold activation for accurate cancer cell identification. J Am Chem Soc 141(32):12738–12743. https://doi.org/10.1021/jacs.9b05470 + + 10.1021/jacs.9b05470 + 31328519 + + + + Dai J, Su Y, Zhong S et al (2020) Exosomes: key players in cancer and potential therapeutic strategy. 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+ + + 36809498 + + 2023 + 02 + 22 + +
+ + 1432-1076 + + + 2023 + Feb + 21 + + + European journal of pediatrics + Eur J Pediatr + + Safety, metabolic and psychological outcomes of Medtronic MiniMed 670G in children, adolescents and young adults: a systematic review. + 10.1007/s00431-023-04833-4 + + Hybrid closed loop (HCL) systems are the combination of a pump for insulin delivery and a glucose sensor for continuous glucose monitoring. These systems are managed by an algorithm, which delivers insulin on the basis of the interstitial glucose levels. The MiniMed™ 670G system was the first HCL system available for clinical purpose. In this paper, we reviewed the literature about metabolic and psychological outcomes in children, adolescents and young adults with type 1 diabetes treated with MiniMed™ 670G. Only 30 papers responded to the inclusion criteria and thus were considered. All the papers show that the system is safe and effective in managing glucose control. Metabolic outcomes are available up to 12 months of follow-up; longer study period are lacking. This HCL system may improve HbA1c up to 7.1% and time in range up to 73%. The time spent in hypoglycaemia is almost neglectable. Better improvement in blood glucose control is observed in patients with higher HbA1c at HCL system start and larger daily use of auto-mode functionality.     Conclusion: The Medtronic MiniMed™ 670G is safe and well accepted, without any increase in the burden for patients. Some papers report an improvement in the psychological outcomes, but other papers do not confirm this finding. So far, it significantly improves the management of diabetes mellitus in children, adolescents and young adults. Proper training and support by the diabetes team are mandatory. Studies for a period longer than 1 year would be appreciated to better understand the potentiality of this system. What is Known: • The Medtronic MiniMedTM 670G is a hybrid closed loop system which combines a continuous glucose monitoring sensor with an insulin pump. • It has been the first hybrid closed loop system available for clinical purpose. Adequate training and patients support play a key role in diabetes management. What is New: • The Medtronic MiniMedTM 670G may improve HbA1c and CGM metrics up to 1-year of follow-up, but the improvement appears lower than advanced hybrid closed loop systems. This system is effective to prevent hypoglycaemia. • The psychosocial effects remain less understood in terms of improvement of psychosocial outcomes. The system has been considered to provide flexibility and independence by the patients and their caregivers. The workload required to use this system is perceived as a burden by the patients who decrease the use of auto-mode functionality over time. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Mameli + Chiara + C + http://orcid.org/0000-0003-3385-4128 + + Department of Pediatrics, Buzzi Children's Hospital, University of Milan, Milan, Italy. + + + Department of Biomedical and Clinical Science, University of Milan, Milan, Italy. + + + + Smylie + Giulia Marie + GM + + Department of Pediatrics, Buzzi Children's Hospital, University of Milan, Milan, Italy. + + + + Galati + Alessio + A + + Metabolic Disorders and Diabetes Unit, "Giovanni XXIII" Children's Hospital, AOU Policlinico-Giovanni XXIII, Bari, Italy. + + + + Rapone + Biagio + B + https://orcid.org/0000-0002-0062-6594 + + Department of Interdisciplinary Medicine, University of Bari "Aldo Moro, 70121, Bari, Italy. + + + + Cardona-Hernandez + Roque + R + https://orcid.org/0000-0002-7067-1657 + + Division of Pediatric Endocrinology, Hospital Sant Joan de Déu, Barcelona, Spain. + + + + Zuccotti + Gianvincenzo + G + http://orcid.org/0000-0002-2795-9874 + + Department of Pediatrics, Buzzi Children's Hospital, University of Milan, Milan, Italy. + + + Department of Biomedical and Clinical Science, University of Milan, Milan, Italy. + + + + Delvecchio + Maurizio + M + http://orcid.org/0000-0002-1528-0012 + + Metabolic Disorders and Diabetes Unit, "Giovanni XXIII" Children's Hospital, AOU Policlinico-Giovanni XXIII, Bari, Italy. mdelvecchio75@gmail.com. + + + + eng + + Journal Article + Review + + + 2023 + 02 + 21 + +
+ + Germany + Eur J Pediatr + 7603873 + 0340-6199 + + IM + + Glucose + Hybrid closed loop (HCL) systems + MiniMed™ 670G system + +
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+ + + 36809502 + + 2023 + 02 + 22 + +
+ + 1432-1335 + + + 2023 + Feb + 21 + + + Journal of cancer research and clinical oncology + J Cancer Res Clin Oncol + + Risk mapping of lung cancer: a comprehensive appraisal of published meta-analyses incorporating Mendelian randomization studies. + 10.1007/s00432-023-04606-4 + + A comprehensive appraisal of published meta-analyses incorporating Mendelian randomization studies was performed to map the different risk factors and assess the causality for lung cancer. + Systematic reviews and meta-analyses of observational and interventional studies were reviewed based on PubMed, Embase, Web of Science, and Cochrane Library. Mendelian randomization analyses were conducted to validate the causal associations of those various exposures with lung cancer using summary statistics from 10 genome-wide association studies (GWAS) consortia and other GWAS databases in MR-Base platform. + In the review of meta-analyses, 105 risk factors associated with lung cancer were identified from 93 articles. It was found that 72 risk factors were nominally significant (P < 0.05) associated with lung cancer. Mendelian randomization analyses were performed to analyze 36 exposures based on 551 SNPs and 4,944,052 individuals, finding that 3 exposures had a consistent risk/protective effect on lung cancer with the results of the meta-analysis. In Mendelian randomization anaylses, smoking (OR 1.44, 95% CI 1.18-1.75; P = 0.001) and blood copper (OR 1.14, 95% CI 1.01-1.29; P = 0.039) significantly associated with increased risk of lung cancer, whereas aspirin use (OR 0.67, 95% CI 0.50-0.89; P = 0.006) showed protective effects. + This study mapped putative associations of risk factors for lung cancer, revealing the causal hazard effect of smoking, blood copper, and the protective effect of aspirin use in the development of lung cancer. + This study is registered with PROSPERO (CRD42020159082). + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Li + Caichen + C + + Department of Thoracic Surgery and Oncology, China State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China. + + + + Li + Jianfu + J + + Department of Thoracic Surgery and Oncology, China State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China. + + + + Xiong + Shan + S + + Department of Thoracic Surgery and Oncology, China State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China. + + + + Zhou + Huaqiang + H + + Department of Medical Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China. + + + + Cai + Xiuyu + X + + Department of General Internal Medicine, State Key Laboratory of Oncology in South China, Collaborative Innovation Centre for Cancer Medicine, Sun Yat-sen University Cancer Centre, Guangzhou, China. + + + + Xie + Zhanhong + Z + + Department of Respiratory Medicine, China State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Disease, Guangzhou, 510120, China. + + + + Peng + Haoxin + H + + Nanshan School, Guangzhou Medical University, Jingxiu Road, Panyu District, Guangzhou, 511436, China. + + + First Clinical School, Guangzhou Medical University, Jingxiu Road, Panyu District, Guangzhou, 511436, China. + + + + Wu + Xiangrong + X + + Nanshan School, Guangzhou Medical University, Jingxiu Road, Panyu District, Guangzhou, 511436, China. + + + First Clinical School, Guangzhou Medical University, Jingxiu Road, Panyu District, Guangzhou, 511436, China. + + + + Zhong + Ran + R + + Department of Thoracic Surgery and Oncology, China State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China. + + + + Jiang + Yu + Y + + Nanshan School, Guangzhou Medical University, Jingxiu Road, Panyu District, Guangzhou, 511436, China. + + + First Clinical School, Guangzhou Medical University, Jingxiu Road, Panyu District, Guangzhou, 511436, China. + + + + Su + Zixuan + Z + + Nanshan School, Guangzhou Medical University, Jingxiu Road, Panyu District, Guangzhou, 511436, China. + + + First Clinical School, Guangzhou Medical University, Jingxiu Road, Panyu District, Guangzhou, 511436, China. + + + + Zhu + Feng + F + + Department of Internal Medicine, Detroit Medical Center/Sinai-Grace Hospital, 4201 St. Antoine, Suite 3R, Detroit, MI, 48201, USA. + + + + Huo + Zhenyu + Z + + Nanshan School, Guangzhou Medical University, Jingxiu Road, Panyu District, Guangzhou, 511436, China. + + + First Clinical School, Guangzhou Medical University, Jingxiu Road, Panyu District, Guangzhou, 511436, China. + + + + Liu + Bo + B + + Academy of Mathematics and Systems Science in the Chinese Academy of Sciences, Beijing, China. + + + + Chi + Wenhao + W + + Academy of Mathematics and Systems Science in the Chinese Academy of Sciences, Beijing, China. + + + + Wang + Huiting + H + + Department of Thoracic Surgery and Oncology, China State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China. + + + + Wen + Yaokai + Y + + Nanshan School, Guangzhou Medical University, Jingxiu Road, Panyu District, Guangzhou, 511436, China. + + + First Clinical School, Guangzhou Medical University, Jingxiu Road, Panyu District, Guangzhou, 511436, China. + + + + Ge + Fan + F + + Nanshan School, Guangzhou Medical University, Jingxiu Road, Panyu District, Guangzhou, 511436, China. + + + First Clinical School, Guangzhou Medical University, Jingxiu Road, Panyu District, Guangzhou, 511436, China. + + + + Feng + Yi + Y + + Nanshan School, Guangzhou Medical University, Jingxiu Road, Panyu District, Guangzhou, 511436, China. + + + First Clinical School, Guangzhou Medical University, Jingxiu Road, Panyu District, Guangzhou, 511436, China. + + + + Wang + Runchen + R + + Nanshan School, Guangzhou Medical University, Jingxiu Road, Panyu District, Guangzhou, 511436, China. + + + First Clinical School, Guangzhou Medical University, Jingxiu Road, Panyu District, Guangzhou, 511436, China. + + + + Chen + Jiana + J + + Nanshan School, Guangzhou Medical University, Jingxiu Road, Panyu District, Guangzhou, 511436, China. + + + First Clinical School, Guangzhou Medical University, Jingxiu Road, Panyu District, Guangzhou, 511436, China. + + + + Chen + Zisheng + Z + + Department of Thoracic Surgery and Oncology, China State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China. + + + + Shi + Jiang + J + + Department of Thoracic Surgery and Oncology, China State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China. + + + + Cheng + Bo + B + + Department of Thoracic Surgery and Oncology, China State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China. + + + + Chen + Zhuxing + Z + + Department of Thoracic Surgery and Oncology, China State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China. + + + + Liang + Hengrui + H + + Department of Thoracic Surgery and Oncology, China State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China. + + + + Li + Feng + F + + Department of Thoracic Surgery and Oncology, China State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China. + + + + Deng + Hongsheng + H + + Department of Thoracic Surgery and Oncology, China State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China. + + + + He + Jianxing + J + + Department of Thoracic Surgery and Oncology, China State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China. drjianxing.he@gmail.com. + + + Southern Medical University, Guangzhou, 510120, China. drjianxing.he@gmail.com. + + + + Liang + Wenhua + W + + Department of Thoracic Surgery and Oncology, China State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China. liangwh1987@163.com. + + + The First People's Hospital of Zhaoqing, Zhaoqing, China. liangwh1987@163.com. + + + + eng + + + 82022048 + National Natural Science Foundation of China + + + + 201804020030 + China National Science Foundation + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + J Cancer Res Clin Oncol + 7902060 + 0171-5216 + + IM + + Causality + Lung cancer + Mendelian randomization + Risk factors + Systematic appraisal + +
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Sci Rep 4:6161 + + 10.1038/srep06161 + 25145261 + 5381428 + + + + MacLean CH, Newberry SJ, Mojica WA et al (2006) Effects of omega-3 fatty acids on cancer risk: a systematic review. JAMA 295(4):403–415 + + 10.1001/jama.295.4.403 + 16434631 + + + + Moher D, Liberati A, Tetzlaff J, Altman DG, Group P (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ 339:b2535 + + 10.1136/bmj.b2535 + 19622551 + 2714657 + + + + National Comprehensive Cancer Network website. NCCN clinical practice guidelines in oncology: lung cancer screening, version 1.2020. www.nccn.org/professionals/physician_gls/default.aspx#lung_screening Accessed Aug 23 2020 + + + Palmer TM, Sterne JA, Harbord RM et al (2011) Instrumental variable estimation of causal risk ratios and causal odds ratios in Mendelian randomization analyses. Am J Epidemiol 173(12):1392–1403 + + 10.1093/aje/kwr026 + 21555716 + + + + Pierce BL, Burgess S (2013) Efficient design for Mendelian randomization studies: subsample and 2-sample instrumental variable estimators. Am J Epidemiol 178(7):1177–1184 + + 10.1093/aje/kwt084 + 23863760 + 3783091 + + + + Rothwell PM, Fowkes FG, Belch JF, Ogawa H, Warlow CP, Meade TW (2011) Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials. Lancet 377(9759):31–41 + + 10.1016/S0140-6736(10)62110-1 + 21144578 + + + + Salanti G, Ioannidis JP (2009) Synthesis of observational studies should consider credibility ceilings. J Clin Epidemiol 62(2):115–122 + + 10.1016/j.jclinepi.2008.05.014 + 19131013 + + + + Salinas CA, Kwon EM, FitzGerald LM et al (2010) Use of aspirin and other nonsteroidal antiinflammatory medications in relation to prostate cancer risk. 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+ + + 36809504 + + 2023 + 02 + 22 + +
+ + 1758-4469 + + + 2023 + Feb + 21 + + + Tree physiology + Tree Physiol + + Functional phenotypic plasticity mediated by water stress and [CO2] explains differences in drought-tolerance of two phylogenetically close conifers. + tpad021 + 10.1093/treephys/tpad021 + + Forests are threatened globally by increased recurrence and intensity of hot droughts. Functionally close coexisting species may exhibit differences in drought-vulnerability large enough to cause niche differentiation and affect forest dynamics. The effect of rising atmospheric [CO2], which could partly alleviate the negative effects of drought, may also differ between species. We analyzed functional plasticity on seedlings of two taxonomically close pine species (Pinus pinaster, Pinus pinea) under different [CO2] and water stress levels. The multidimensional functional trait variability was more influenced by water stress (preferentially xylem traits) and [CO2] (mostly leaf traits) than by differences between species. However, we observed differences between species in the strategies followed to coordinate their hydraulic and structural traits under stress. Leaf 13C discrimination decreased with water stress and increased under elevated [CO2]. Under water stress both species increased their sapwood-area to leaf-area ratios, tracheid density and xylem cavitation, whereas they reduced tracheid lumen area and xylem conductivity. P. pinea was more anisohydric than P. pinaster. P. pinaster produced larger conduits under well-watered conditions than P. pinea. P. pinea was more tolerant to water stress and more resistant to xylem cavitation under low water potentials. The higher xylem plasticity in P. pinea, particularly in tracheid lumen area, expressed a higher capacity of acclimation to water stress than P. pinaster. In contrast, P. pinaster coped with water stress comparatively more by increasing plasticity of leaf hydraulic traits. Despite the small differences observed in the functional response to water stress and drought-tolerance between species, these interspecific differences agreed with ongoing substitution of P. pinaster by P. pinea in forests where both species co-occur. Increased [CO2] had little effect on the species-specific relative performance. Thus, a competitive advantage under moderate water stress of P. pinea compared to P. pinaster is expected to continue in the future. + © The Author(s) 2023. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. + + + + Férriz + M + M + + ICIFOR-INIA, CSIC. Ctra. La Coruña km 7.5, 28040 Madrid, Spain. + + + + Martin-Benito + D + D + + ICIFOR-INIA, CSIC. Ctra. La Coruña km 7.5, 28040 Madrid, Spain. + + + + Fernández-De-Simón + M B + MB + + ICIFOR-INIA, CSIC. Ctra. La Coruña km 7.5, 28040 Madrid, Spain. + + + + Conde + M + M + + ICIFOR-INIA, CSIC. Ctra. La Coruña km 7.5, 28040 Madrid, Spain. + + + + García-Cervigón + A I + AI + + Rey Juan Carlos University, c/Tulipán s/n, 28933 Móstoles, Spain. + + + + Aranda + I + I + 0000-0001-9086-7940 + + ICIFOR-INIA, CSIC. Ctra. La Coruña km 7.5, 28040 Madrid, Spain. + + + + Gea-Izquierdo + G + G + 0000-0003-0148-3721 + + ICIFOR-INIA, CSIC. Ctra. La Coruña km 7.5, 28040 Madrid, Spain. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Canada + Tree Physiol + 100955338 + 0829-318X + + IM + + Mediterranean + drought vulnerability + functional plasticity + global change + hydraulic conductivity + isohydric species + +
+ + + + 2022 + 12 + 12 + + + 2023 + 02 + 08 + + + 2023 + 2 + 22 + 13 + 50 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809504 + 7049626 + 10.1093/treephys/tpad021 + + +
+ + + 36809508 + + 2023 + 02 + 22 + +
+ + 1433-7347 + + + 2023 + Feb + 21 + + + Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA + Knee Surg Sports Traumatol Arthrosc + + Intelligent innovations for our journal's path forward. + 10.1007/s00167-023-07354-7 + + + Dahmen + Jari + J + http://orcid.org/0000-0002-6849-1008 + + Amsterdam UMC, Location AMC, Department of Orthopaedic Surgery and Sports Medicine, University of Amsterdam, Amsterdam Movement Sciences, Meibergdreef 9, Amsterdam, The Netherlands. j.dahmen@amsterdamumc.nl. + + + Academic Center for Evidence Based Sports Medicine (ACES), Amsterdam, The Netherlands. j.dahmen@amsterdamumc.nl. + + + Amsterdam Collaboration for Health and Safety in Sports (ACHSS), International Olympic Committee (IOC) Research Center Amsterdam UMC, Amsterdam, The Netherlands. j.dahmen@amsterdamumc.nl. + + + + Kayaalp + M Enes + ME + + Department for Orthopaedics and Traumatology, Istanbul Kartal Dr. Lutfi Kirdar Training and Research Hospital, Istanbul, Turkey. + + + + Winkler + Philipp W + PW + + Department of Orthopaedics and Traumatology, Kepler University Hospital Linz, Linz, Austria. + + + + Ollivier + Matthieu + M + + Aix Marseille Univ, CNRS, ISM, Inst Movement Sci, Marseille, France. + + + + Pareek + Ayoosh + A + + Sports Medicine and Shoulder Service, Department of Orthopedic Surgery, Hospital for Special Surgery, 535 East 70th Street, New York, NY, 10021, USA. + + + + Karlsson + Jon + J + + Department for Orthopaedics, Sahlgrenska University Hospital, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden. + + + + Hirschmann + Michael T + MT + + Department of Orthopedic Surgery and Traumatology, Head Knee Surgery and DKF Head of Research, Kantonsspital Baselland, Bruderholz, 4101, Bottmingen, Switzerland. + + + + eng + + Editorial + + + 2023 + 02 + 21 + +
+ + Germany + Knee Surg Sports Traumatol Arthrosc + 9314730 + 0942-2056 + + IM + + AI + Editorial + Future + Innovation + +
+ + + + 2023 + 02 + 05 + + + 2023 + 02 + 10 + + + 2023 + 2 + 22 + 13 + 51 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809508 + 10.1007/s00167-023-07354-7 + 10.1007/s00167-023-07354-7 + + +
+ + + 36809506 + + 2023 + 02 + 22 + +
+ + 0973-7693 + + + 2023 + Feb + 21 + + + Indian journal of pediatrics + Indian J Pediatr + + Clinical Evaluation of a Wireless Device for Monitoring Vitals in Newborn Babies. + 10.1007/s12098-022-04459-8 + + To evaluate the ability of the Nemocare Raksha (NR), an internet of things (IoT)-enabled device, to continuously monitor vitals for 6 h and its safety in newborns. The accuracy of the device was also compared with the readings from the standard device used in the pediatric ward. + Forty neonates (either gender) weighing ≥ 1.5 kg were included in the study. Heart rate, respiratory rate, body temperature, and oxygen saturation was measured using the NR and compared with standard care devices. Safety was assessed by monitoring for skin changes and local rise in temperature. The neonatal infant pain scale (NIPS) was used to assess pain and discomfort. + A total of 227 h of observations (5.67 h per baby) were obtained. No discomfort or device-related adverse events were noted during the study period. The mean difference between the NR and the standard monitoring was 0.66 (0.42 to 0.90) for temperature (°C); -6.57 (-8.66 to -4.47) for heart rate (bpm); 7.60 (6.52 to 8.68) for respiratory rate (breaths per minute); -0.79 (-1.10 to -0.48) for oxygen saturation (%). The level of agreement analyzed using the intraclass correlation coefficient (ICC) was good for heart rate [ICC 0.77 (0.72 to 0.82); p value < 0.001] and oxygen saturation [ICC 0.80 (0.75 to 0.84); p value < 0.001]; moderate for body temperature [ICC 0.54 (0.36 to 0.60); p value < 0.001] and poor for respiratory rate [ICC 0.30 (0.10 to 0.44); p value 0.002]. + The NR was able to seamlessly monitor vital parameters in neonates without any safety concern. The device showed a good level of agreement for heart rate and oxygen saturation among the four parameters measured. + © 2023. The Author(s), under exclusive licence to Dr. K C Chaudhuri Foundation. + + + + Aggarwal + Rajiv + R + + Department of Pediatrics, Narayana Hrudayalaya, Bangalore, Karnataka, India. + + + + Gunaseelan + Vikneswaran + V + + Department of Clinical Research, Narayana Hrudayalaya, Bangalore, Karnataka, India. vikneswaran.g.dr@narayanahealth.org. + + + + Manual + Delitia + D + + Department of Clinical Research, Narayana Hrudayalaya, Bangalore, Karnataka, India. + + + + Sanker + Manoj + M + + Nemocare Wellness Pvt. Ltd., Hyderabad, Telangana, India. + + + + Prabaaker + Sabari + S + + Nemocare Wellness Pvt. Ltd., Hyderabad, Telangana, India. + + + + eng + + + BIRAC/IKP0806/BIG-13/18 + BIRAC grant + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + India + Indian J Pediatr + 0417442 + 0019-5456 + + IM + + Medical device + Neonates + Outcomes + Remote monitoring + Sensor + Vitals + +
+ + + + 2022 + 06 + 16 + + + 2022 + 11 + 13 + + + 2023 + 2 + 22 + 13 + 51 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809506 + 10.1007/s12098-022-04459-8 + 10.1007/s12098-022-04459-8 + + + + World Health Organization. Newborns: improving survival and well-being. 2020. Available at: https://www.who.int/news-room/fact-sheets/detail/newborns-reducing-mortality . Accessed on 9 Feb 2022. + + + India State-Level Disease Burden Initiative Child Mortality Collaborators. Subnational mapping of under-5 and neonatal mortality trends in India: The Global Burden of Disease Study 2000–17. Lancet. 2020;395:1640–58. + + 10.1016/S0140-6736(20)30471-2 + + + + Ministry of Health and Family Welfare, Government of India. INAP: India Newborn Action Plan. 2014. Available at: https://www.newbornwhocc.org/INAP_Final.pdf . Accessed on 10 Sept 2019. + + + Ministry of Health and Family Welfare, Government of India. National Health Policy 2017. 2017. Available at: https://main.mohfw.gov.in/sites/default/files/9147562941489753121.pdf . Accessed on 10 Sept 2019. + + + Ginsburg AS, Nkwopara E, Macharia W, et al Evaluation of non-invasive continuous physiological monitoring devices for neonates in Nairobi, Kenya: a research protocol. BMJ Open. 2020;10:e035184. + + + Chan PY, McNeil J, Nguyen T, Ryan N, Hopper I. Novel wearable and contactless monitoring devices to identify deteriorating patients in the clinical setting: a systematic review protocol. Syst Rev. 2020;9:104. + + 10.1186/s13643-020-01370-1 + 32375867 + 7201723 + + + + Nuttall G, Burckhardt J, Hadley A, et al. Surgical and patient risk factors for severe arterial line complications in adults. Anesthesiology. 2016;124:590–7. + + 10.1097/ALN.0000000000000967 + 26640979 + + + + Zargaran D, Hardwick S, Adel R, Hill G, Stubbins D, Salmasi AM. Sphygmomanometer cuffs: a potential source of infection! Angiology. 2015;66:118–21. + + 10.1177/0003319714522855 + 24569512 + + + + Hunter A, Johnson L, Coustasse A. Reduction of intensive care unit length of stay: the case of early mobilization. Health Care Manag (Frederick). 2014;33:128–35. + + 10.1097/HCM.0000000000000006 + 24776831 + + + + Hasan MNU, Negulescu II. Wearable technology for baby monitoring: a review. J Textile Eng Fashion Technol. 2020;6:112–20. + + 10.15406/jteft.2020.06.00239 + + + + ISO 14971:2019 Medical devices — Application of risk management to medical devices. Available at: https://www.iso.org/standard/72704.html . Accessed on 8 June 2022. + + + Obiedat H, Al-Maaitah EI. Critique of the use of Neonatal Infant Pain Scale (NIPS). Neonat Pediatr Med. 2020;6:186. + + + Mukaka MM. Statistics corner: A guide to appropriate use of correlation coefficient in medical research. Malawi Med J. 2012;24:69–71. + + 23638278 + 3576830 + + + + Leenen JPL, Leerentveld C, van Dijk JD, van Westreenen HL, Schoonhoven L, Patijn GA. Current evidence for continuous vital signs monitoring by wearable wireless devices in hospitalized adults: Systematic Review. J Med Internet Res. 2020;22:e18636. + + 10.2196/18636 + 32469323 + 7351263 + + + + Chung HU, Kim BH, Lee JY, et al. Binodal, wireless epidermal electronic systems with in-sensor analytics for neonatal intensive care. Science. 2019;363:eaau0780. + + + Chung HU, Rwei AY, Hourlier-Fargette A, et al. Skin-interfaced biosensors for advanced wireless physiological monitoring in neonatal and pediatric intensive-care units. Nat Med. 2020;26:418–29. + + 10.1038/s41591-020-0792-9 + 32161411 + 7315772 + + + + Rao H, Saxena D, Kumar S, et al. Low power remote neonatal temperature monitoring device. Biodevices. 2014;28‒38. https://doi.org/10.5220/0004798300280038 . + + + Mansab F, Donnelly H, Kussner A, Neil J, Bhatti S, Goyal DK. Oxygen and mortality in COVID-19 pneumonia: A comparative analysis of supplemental oxygen policies and health outcomes across 26 countries. Front Public Health. 2021;9:580585. + + 10.3389/fpubh.2021.580585 + 34327182 + 8313806 + + + + NHS. Pulse oximetry to detect early deterioration of patients with COVID-19 in primary and community care settings, 2020. Available at: https://www.england.nhs.uk/coronavirus/publication/pulse-oximetry-to-detect-early-deterioration-of-patients-with-covid-19-in-primary-and-community-care-settings/ . Accessed on 8 June 2022 + + + Vindrola-Padros C, Singh KE, Sidhu MS, et al. Remote home monitoring (virtual wards) for confirmed or suspected COVID-19 patients: A rapid systematic review. EClin Med. 2021;37:100965. + + + Cruz J, Brooks D, Marques A. Home telemonitoring effectiveness in COPD: a systematic review. Int J Clin Pract. 2014;68:369–78. + + 10.1111/ijcp.12345 + 24472009 + + + + Faes L, Bachmann LM, Sim DA. Home monitoring as a useful extension of modern tele-ophthalmology. Eye (Lond). 2020;34:1950–3. + + 10.1038/s41433-020-0964-3 + 32405047 + 7784909 + + + + +
+ + + 36809505 + + 2023 + 02 + 22 + +
+ + 1438-8359 + + + 2023 + Feb + 21 + + + Journal of anesthesia + J Anesth + + Assessment of efficiency of mirror therapy in preventing phantom limb pain in patients undergoing below-knee amputation surgery-a randomized clinical trial. + 10.1007/s00540-023-03173-9 + + Phantom limb pain (PLP) is a major cause of physical limitation and disability accounting for about 85% of amputated patients. Mirror therapy is used as a therapeutic modality for patients with phantom limb pain. Primary objective was to study the incidence of PLP at 6 months following below-knee amputation between the mirror therapy group and control group. + Patients posted for below-knee amputation surgery were randomized into two groups. Patients allocated to group M received mirror therapy in post-operative period. Two sessions of therapy were given per day for 7 days and each session lasted for 20 min. Patients who developed pain from the missing portion of the amputated limb were considered to have PLP. All patients were followed up for six months and the time of occurrence of PLP and intensity of the pain were recorded among other demographic factors. + A total of 120 patients completed the study after recruitment. The demographic parameters were comparable between the two groups. Overall incidence of phantom limb pain was significantly higher in the control group (Group C) when compared to the mirror therapy (Group M) group [Group M = 7 (11.7%) vs Group C = 17 (28.3%); p = 0.022]. Intensity of PLP measured on the Numerical Rating Scale (NRS) was significantly lower at 3 months in Group M compared to Group C among patients who developed PLP [NRS - median (Inter quartile range): Group M 5 (4,5) vs Group C 6 (5,6); p 0.001]. + Mirror therapy reduced the incidence of phantom limb pain when administered pre-emptively in patients undergoing amputation surgeries. The severity of the pain was also found to be lower at 3 months in patients who received pre-emptive mirror therapy. + This prospective study was registered in the clinical trial registry of India. + CTRI/2020/07/026488. + © 2023. The Author(s) under exclusive licence to Japanese Society of Anesthesiologists. + + + + Purushothaman + Samatharman + S + + Department of Anaesthesiology and Critical Care, Second Floor, Institute Block, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, 605006, India. + + + + Kundra + Pankaj + P + + Department of Anaesthesiology and Critical Care, Second Floor, Institute Block, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, 605006, India. p_kundra@hotmail.com. + + + + Senthilnathan + Muthapillai + M + + Department of Anaesthesiology and Critical Care, Second Floor, Institute Block, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, 605006, India. + + + + Sistla + Sarath Chandra + SC + + Department of Surgery, Sri Manakula Vinayagar Medical College and Hospital, Puducherry, India. + + + + Kumar + Shathish + S + + Department of Anaesthesiology, Manipal Hospital Whitefield, Bangalore, Karnataka, India. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Japan + J Anesth + 8905667 + 0913-8668 + + IM + + NRS score + Phantom Limb Pain + Phantom Limb Sensation + Preemptive Mirror Therapy + +
+ + + + 2022 + 10 + 02 + + + 2023 + 02 + 06 + + + 2023 + 2 + 22 + 13 + 50 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809505 + 10.1007/s00540-023-03173-9 + 10.1007/s00540-023-03173-9 + + + + Rahimi A, Mousavi B, Soroush M, Masumi M, Montazeri A. Pain and health-related quality of life in war veterans with bilateral lower limb amputations. Trauma Mon. 2012;17:282–6. + + 10.5812/traumamon.5135 + 24350107 + 3860634 + + + + Ehde DM, Czerniecki JM, Smith DG, Campbell KM, Edwards WT, Jensen MP. Chronic phantom sensations, phantom pain, residual limb pain, and other regional pain after lower limb amputation. Arch Phys Med Rehabil. 2000;81:1039–44. + + 10.1053/apmr.2000.7583 + 10943752 + + + + Kern U, Busch V, Rockland M, Kohl M. Birklein F [Prevalence and risk factors of phantom limb pain and phantom limb sensations in Germany. A nationwide field survey]. Schmerz Berl Ger. 2009;23:479–88. + + 10.1007/s00482-009-0786-5 + + + + Jensen TS, Krebs B, Nielsen J, Rasmussen P. Immediate and long-term phantom limb pain in amputees: incidence, clinical characteristics and relationship to pre-amputation limb pain. Pain. 1985;21:267–78. + + 10.1016/0304-3959(85)90090-9 + 3991231 + + + + Davidson JH, Khor KE, Jones LE. A cross-sectional study of post-amputation pain in upper and lower limb amputees, experience of a tertiary referral amputee clinic. Disabil Rehabil. 2010;32:1855–62. + + 10.3109/09638281003734441 + 20345252 + + + + Hirsh AT, Dillworth TM, Ehde DM, Jensen MP. Sex differences in pain and psychological functioning in persons with limb loss. J Pain. 2010;11:79–86. + + 10.1016/j.jpain.2009.06.004 + 19734105 + + + + Flor H, Nikolajsen L, Staehelin JT. Phantom limb pain: a case of maladaptive CNS plasticity? Nat Rev Neurosci. 2006;7:873–81. + + 10.1038/nrn1991 + 17053811 + + + + Vaso A, Adahan H-M, Gjika A, Zahaj S, Zhurda T, Vyshka G. Peripheral nervous system origin of phantom limb pain. Pain. 2014;155:1384–91. + + 10.1016/j.pain.2014.04.018 + 24769187 + + + + Costigan M, Scholz J, Woolf CJ. Neuropathic pain: a maladaptive response of the nervous system to damage. Annu Rev Neurosci. 2009;32:1–32. + + 10.1146/annurev.neuro.051508.135531 + 19400724 + 2768555 + + + + Dickinson BD, Head CA, Gitlow S, Osbahr AJ. Maldynia: pathophysiology and management of neuropathic and maladaptive pain—a report of the AMA Council on Science and Public Health. Pain Med Malden Mass. 2010;11:1635–53. + + 10.1111/j.1526-4637.2010.00986.x + + + + Ramachandran VS, Brang D, McGeoch PD. Dynamic reorganization of referred sensations by movements of phantom limbs. NeuroReport. 2010;21:727–30. + + 10.1097/WNR.0b013e32833be9ab + 20523250 + + + + Dijkstra PU, Geertzen JHB, Stewart R, van der Schans CP. Phantom pain and risk factors: a multivariate analysis. J Pain Symptom Manage. 2002;24:578–85. + + 10.1016/S0885-3924(02)00538-9 + 12551807 + + + + Limakatso K, Bedwell GJ, Madden VJ, Parker R. The prevalence and risk factors for phantom limb pain in people with amputations: a systematic review and meta-analysis. PLoS ONE. 2020;15: e0240431. + + 10.1371/journal.pone.0240431 + 33052924 + 7556495 + + + + Hanley MA, Ehde DM, Campbell KM, Osborn B, Smith DG. Self-reported treatments used for lower-limb phantom pain: descriptive findings. Arch Phys Med Rehabil. 2006;87:270–7. + + 10.1016/j.apmr.2005.04.025 + 16442984 + + + + Subedi B, Grossberg GT. Phantom limb pain: mechanisms and treatment approaches. Pain Res Treat. 2011;2011: 864605. + + 22110933 + 3198614 + + + + Wittkopf PG, Johnson MI. Mirror therapy: a potential intervention for pain management. Rev Assoc Med Bras. 1992;2017(63):1000–5. + + + Kaur A, Guan Y. Phantom limb pain: a literature review. Chin J Traumatol Zhonghua Chuang Shang Za Zhi. 2018;21(6):366–8. + + 10.1016/j.cjtee.2018.04.006 + 30583983 + + + + Brodie EE, Whyte A, Waller B. Increased motor control of a phantom leg in humans results from the visual feedback of a virtual leg. Neurosci Lett. 2003;341:167–9. + + 10.1016/S0304-3940(03)00160-5 + 12686392 + + + + Giummarra MJ, Moseley GL. Phantom limb pain and bodily awareness: current concepts and future directions. Curr Opin Anaesthesiol. 2011;24:524–31. + + 10.1097/ACO.0b013e32834a105f + 21772144 + + + + Zheng B, Yin Y, Xiao H, Lui S, Wen C, Dai Y. Altered cortical reorganization and brain functional connectivity in phantom limb pain: a functional MRI study. Pain Pract. 2021;21(4):394–403. + + 10.1111/papr.12966 + 33202107 + + + + MacIver K, Lloyd DM, Kelly S, Roberts N, Nurmikko T. Phantom limb pain, cortical reorganization and the therapeutic effect of mental imagery. 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+ + + 36809507 + + 2023 + 02 + 22 + +
+ + 1538-2443 + + + 2023 + Feb + 21 + + + Journal of neurovirology + J Neurovirol + + Cortico-striatal networking deficits associated with advanced HIV disease and cocaine use. + 10.1007/s13365-023-01120-8 + + Cocaine use is disproportionately prevalent in people with HIV (PWH) and is known to potentiate HIV neuropathogenesis. As both HIV and cocaine have well-documented cortico-striatal effects, PWH who use cocaine and have a history of immunosuppression may exhibit greater FC deficits compared to PWH without these conditions. However, research investigating the legacy effects of HIV immunosuppression (i.e., a history of AIDS) on cortico-striatal functional connectivity (FC) in adults with and without cocaine use is sparse. Resting-state functional magnetic resonance imaging (fMRI) and neuropsychological assessment data from 273 adults were analyzed to examine FC in relation to HIV disease: HIV-negative (n = 104), HIV-positive with nadir CD4 ≥ 200 (n = 96), HIV-positive with nadir CD4 < 200 (AIDS; n = 73), and cocaine use (83 COC and 190 NON). Using independent component analysis/dual regression, FC was assessed between the basal ganglia network (BGN) and five cortical networks: dorsal attention network (DAN), default mode network, left executive network, right executive network, and salience network. There were significant interaction effects such that AIDS-related BGN-DAN FC deficits emerged in COC but not in NON participants. Independent of HIV, cocaine effects emerged in FC between the BGN and executive networks. Disruption of BGN-DAN FC in AIDS/COC participants is consistent with cocaine potentiation of neuro-inflammation and may be indicative of legacy HIV immunosuppressive effects. The current study bolsters previous findings linking HIV and cocaine use with cortico-striatal networking deficits. Future research should consider the effects of the duration of HIV immunosuppression and early treatment initiation. + © 2023. The Author(s) under exclusive licence to The Journal of NeuroVirology, Inc. + + + + Al-Khalil + Kareem + K + http://orcid.org/0000-0003-1387-6733 + + Psychiatry and Behavioral Sciences, Duke University School of Medicine, Box 102848, Durham, NC, 27710, USA. kareem.alkhalil@duke.edu. + + + + Bell + Ryan P + RP + + Psychiatry and Behavioral Sciences, Duke University School of Medicine, Box 102848, Durham, NC, 27710, USA. + + + + Towe + Sheri L + SL + + Psychiatry and Behavioral Sciences, Duke University School of Medicine, Box 102848, Durham, NC, 27710, USA. + + + + Gadde + Syam + S + + Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC, 27710, USA. + + + + Burke + Emma + E + + Psychiatry and Behavioral Sciences, Duke University School of Medicine, Box 102848, Durham, NC, 27710, USA. + + + + Meade + Christina S + CS + + Psychiatry and Behavioral Sciences, Duke University School of Medicine, Box 102848, Durham, NC, 27710, USA. + + + + eng + + + R01-DA045565 + NH + NIH HHS + United States + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + J Neurovirol + 9508123 + 1355-0284 + + IM + + Cocaine + Functional connectivity + HIV disease + Nadir CD4 + Resting state networks + +
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Brain Connect 1(3):207–217. https://doi.org/10.1089/brain.2011.0016 + + 10.1089/brain.2011.0016 + 22433049 + 3621309 + + + + Wang Y, Liu M, Lu Q, Farrell M, Lappin JM, Shi J, Bao Y (2020) Global prevalence and burden of HIV-associated neurocognitive disorder: a meta-analysis. Neurology 95(19):e2610–e2621. https://doi.org/10.1212/WNL.0000000000010752 + + 10.1212/WNL.0000000000010752 + 32887786 + + + + Wechsler D (2008) Wechsler Adult Intelligence Scale. San Antonio, TX, Pearson Assessment + + + Yang FN, Hassanzadeh-Behbahani S, Kumar P, Moore DJ, Ellis RJ, Jiang X (2022) The impacts of HIV infection, age, and education on functional brain networks in adults with HIV. J Neurovirol 28(2):265–273. https://doi.org/10.1007/s13365-021-01039-y + + 10.1007/s13365-021-01039-y + 35044643 + 9584140 + + + + Zayyad Z, Spudich S (2015) Neuropathogenesis of HIV: from initial neuroinvasion to HIV-associated neurocognitive disorder (HAND). Curr HIV/AIDS Rep 12(1):16–24. https://doi.org/10.1007/s11904-014-0255-3 + + 10.1007/s11904-014-0255-3 + 25604237 + 4741099 + + + + Zhang S, Li CR (2018) Ventral striatal dysfunction in cocaine dependence - difference mapping for subregional resting state functional connectivity. Transl Psychiatry 8(1):119. https://doi.org/10.1038/s41398-018-0164-0 + + 10.1038/s41398-018-0164-0 + 29915214 + 6006289 + + + + Zhuang Y, Qiu X, Wang L, Ma Q, Mapstone M, Luque A, Schifitto G (2017) Combination antiretroviral therapy improves cognitive performance and functional connectivity in treatment-naive HIV-infected individuals. J Neurovirol 23(5):704–712. https://doi.org/10.1007/s13365-017-0553-9 + + 10.1007/s13365-017-0553-9 + 28791662 + 5655604 + + + + +
+ + + 36809509 + + 2023 + 02 + 22 + +
+ + 1433-7347 + + + 2023 + Feb + 21 + + + Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA + Knee Surg Sports Traumatol Arthrosc + + Survival of anterior cruciate ligament reconstructions in active-duty military populations. + 10.1007/s00167-023-07335-w + + Anterior cruciate ligament tears and anterior cruciate ligament reconstruction (ACLR) are common in young athletes. The modifiable and non-modifiable factors contributing to ACLR failure and reoperation are incompletely understood. The purpose of this study was to determine ACLR failure rates in a physically high-demand population and identify the patient-specific risk factors, including prolonged time between diagnosis and surgical correction, that portend failure. + A consecutive series of military service members with ACLR with and without concomitant procedures (meniscus [M] and/or cartilage [C]) done at military facilities between 2008 and 2011 was completed via the Military Health System Data Repository. This was a consecutive series of patients without a history of knee surgery for two years prior to the primary ACLR. Kaplan-Meier survival curves were estimated and evaluated with Wilcoxon test. Cox proportional hazard models calculated hazard ratios (HR) with 95% confidence intervals (95% CI) to identify demographic and surgical factors that influenced ACLR failure. + Of the 2735 primary ACLRs included in the study, 484/2,735 (18%) experienced ACLR failure within four years, including (261/2,735) (10%) undergoing revision ACLR and (224/2,735) (8%) due to medical separation. The factors that increased failure include Army Service (HR 2.19, 95% CI 1.67, 2.87), > 180 days from injury to ACLR (HR 1.550, 95% CI 1.157, 2.076), tobacco use (HR 1.429 95% CI 1.174, 1.738), and younger patient age (HR 1.024, 95% CI 1.004, 1.044). + The overall clinical failure rate of service members with ACLR is 17.7% with minimum four-year follow-up, where more patients are likely to fail due to revision surgery than medical separation. The cumulative probability of survival at 4 years was 78.5%. Smoking cessation and treating ACLR patients promptly are modifiable risk factors impacting either graft failure or medical separation. + Level III. + © 2023. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply. + + + + Anderson + Ashley B + AB + http://orcid.org/0000-0002-0811-1253 + + Uniformed Services University-Walter Reed National Military Medical Center Department of Surgery Division of Orthopaedics, 8901 Wisconsin Ave, Bethesda, MD, 20814, USA. ashleybeeanderson@gmail.com. + + + + Dekker + Travis J + TJ + + Department of Orthopaedics, Eglin Air Force Base, Eglin, FL, USA. + + + + Pav + Veronika + V + + Kennell & Associates, Inc., Falls Church, VA, USA. + + + Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. + + + + Mauntel + Timothy C + TC + + DoD-VA Extremity Trauma and Amputation Center of Excellence, Fort Bragg, NC, USA. + + + + Provencher + Matthew T + MT + + The Steadman Philippon Research Institute, Vail, CO, USA. + + + + Tokish + John M + JM + + Mayo Clinic, Scottsdale, AZ, USA. + + + + Volker + Musahl + M + + Medical Center Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA, USA. + + + + Sansone + Michael + M + + Department of Orthopaedics Sahlgrenska Academy, Sahlgrenska University Hospital, Göteborg, Sweden. + + + Gothenburg University, Göteborg, Sweden. + + + + Karlsson + Jon + J + + Department of Orthopaedics Sahlgrenska Academy, Sahlgrenska University Hospital, Göteborg, Sweden. + + + Gothenburg University, Göteborg, Sweden. + + + + Dickens + Jonathan F + JF + + Uniformed Services University-Walter Reed National Military Medical Center Department of Surgery Division of Orthopaedics, 8901 Wisconsin Ave, Bethesda, MD, 20814, USA. + + + Department of Orthopaedics Sahlgrenska Academy, Sahlgrenska University Hospital, Göteborg, Sweden. + + + Gothenburg University, Göteborg, Sweden. + + + Department of Orthopaedic Surgery, Duke University, Durham, NC, USA. + + + John A. Feagin Jr. Sports Medicine Fellowship, Keller Army Community Hospital, United States Military Academy, West Point, NY, USA. + + + Duke University Hospital Department of Orthopaedics, Durham, NC, USA. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Knee Surg Sports Traumatol Arthrosc + 9314730 + 0942-2056 + + IM + + ACL + ACL outcomes + ACL survival + Risk factors for failure + +
+ + + + 2022 + 10 + 09 + + + 2023 + 01 + 30 + + + 2023 + 2 + 22 + 13 + 51 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809509 + 10.1007/s00167-023-07335-w + 10.1007/s00167-023-07335-w + + + + Antosh IJ, Patzkowski JC, Racusin AW, Aden JK, Waterman SM (2017) Return to military duty after anterior cruciate ligament reconstruction. Mil Med 183:e83–e89 + + 10.1093/milmed/usx007 + + + + de Campos GC, Nery W, Teixeira PEP, Araujo PH, de Alves WM (2016) Association between meniscal and chondral lesions and timing of anterior cruciate ligament reconstruction. Orthop J Sports Med 4:2325967116669309 + + 10.1177/2325967116669309 + 27803940 + 5076747 + + + + Cullison TR, O’Brien TJ, Getka K, Jonson S (1998) Anterior cruciate ligament reconstruction in the military patient. Mil Med 163:17–19 + + 10.1093/milmed/163.1.17 + 9465566 + + + + Dekker TJ, Godin JA, Dale KM, Garrett WE, Taylor DC, Riboh JC (2017) Return to sport after pediatric anterior cruciate ligament reconstruction and its effect on subsequent anterior cruciate ligament injury. J Bone Joint Surg 99:897–904 + + 10.2106/JBJS.16.00758 + 28590374 + + + + Dekker TJ, Rush JK, Schmitz MR (2018) What’s new in pediatric and adolescent anterior cruciate ligament injuries&quest. J Pediatr Orthoped 38:185–192 + + 10.1097/BPO.0000000000000792 + + + + Edwards KJ, Goral AB, Hay RM, Kelso T (1991) Functional restoration following anterior cruciate ligament reconstruction in active-duty military personnel. Mil Med 156:118–121 + + 10.1093/milmed/156.3.118 + 1901971 + + + + Flint JH, Wade AM, Giuliani J, Rue J-P (2014) Defining the terms acute and chronic in orthopaedic sports injuries. Am J Sports Med 42:235–241 + + 10.1177/0363546513490656 + 23749341 + + + + Group TMK, Spindler KP, Huston LJ, Chagin KM, Kattan MW, Reinke EK, Amendola A, Andrish JT, Brophy RH, Cox CL, Dunn WR, Flanigan DC, Jones MH, Kaeding CC, Magnussen RA, Marx RG, Matava MJ, McCarty EC, Parker RD, Pedroza AD, Vidal AF, Wolcott ML, Wolf BR, Wright RW (2018) Ten-year outcomes and risk factors after anterior cruciate ligament reconstruction: a MOON longitudinal prospective cohort study. Am J Sports Med 46:815–825 + + 10.1177/0363546517749850 + + + + Hettrich CM, Dunn WR, Reinke EK, Group M, Spindler KP, Parker RD, Andrish JT, Kaeding CC, Amendola A, Wright RW, Marx RG, McCarty EC (2013) The rate of subsequent surgery and predictors after anterior cruciate ligament reconstruction. Am J Sports Med 41:1534–1540 + + 10.1177/0363546513490277 + 23722056 + 4195486 + + + + Kaeding CC, Pedroza AD, Reinke EK, Huston LJ, Consortium M, Spindler KP, Amendola A, Andrish JT, Brophy RH, Dunn WR, Flanigan D, Hewett TE, Jones MH, Marx RG, Matava MJ, McCarty EC, Parker RD, Wolcott M, Wolf BR, Wright RW (2015) Risk factors and predictors of subsequent ACL injury in either knee after ACL reconstruction. Am J Sports Med 43:1583–1590 + + + Kanneganti P, Harris JD, Brophy RH, Carey JL, Lattermann C, Flanigan DC (2012) The effect of smoking on ligament and cartilage surgery in the knee. Am J Sports Med 40:2872–2878 + + 10.1177/0363546512458223 + 22972849 + 3978172 + + + + Krutsch W, Zellner J, Baumann F, Pfeifer C, Nerlich M, Angele P (2017) Timing of anterior cruciate ligament reconstruction within the first year after trauma and its influence on treatment of cartilage and meniscus pathology. Knee Surg Sports Traumatol Arthrosc 25:418–425 + + 10.1007/s00167-015-3830-2 + + + + Lynch TB, Patzkowski JC, Swan ER, Roach CJ, Schmitz MR, Dickens JF, Sheean AJ (2020) Current practice patterns in anterior cruciate ligament reconstruction among fellowship-trained military orthopaedic surgeons. Arthrosc Sports Med Rehabil 2:e523–e529 + + 10.1016/j.asmr.2020.06.003 + 33134990 + 7588646 + + + + Mather RC, Hettrich CM, Dunn WR, Cole BJ, Bach BR, Huston LJ, Reinke EK, Spindler KP, Koenig L, Amendola A, Andrish JT, Kaeding CK, Marx RG, McCarty EC, Parker RD, Wright RW (2014) Cost-effectiveness analysis of early reconstruction versus rehabilitation and delayed reconstruction for anterior cruciate ligament tears. Am J Sports Med 42:1583–1591 + + 10.1177/0363546514530866 + 4222991 + + + + Meighan AAS, Keating JF, Will E (2003) Outcome after reconstruction of the anterior cruciate ligament in athletic patients. Bone Joint J 85-B:521–524 + + + Owens BD, Mountcastle SB, Dunn WR, DeBerardino TM, Taylor DC (2007) Incidence of anterior cruciate ligament injury among active duty US Military Servicemen and Servicewomen. Mil Med 172:90–91 + + 10.7205/MILMED.172.1.90 + 17274274 + + + + Pandya NK, Feeley B, Lansdown D, Rubenstein W, Allahabadi S (2019) ACL graft failure in professional athletes compared to the pediatric population. Orthop J Sports Med 7:2325967119S00102 + + 10.1177/2325967119S00102 + 6446390 + + + + Peebles LA, O’Brien LT, Dekker TJ, Kennedy MI, Akamefula R, Provencher MT (2019) The warrior athlete part 2—return to duty in the US military: advancing ACL rehabilitation in the tactical athlete. Sports Med Arthrosc 27:e12–e24 + + 10.1097/JSA.0000000000000237 + + + + Tennent DJ, Posner MA (2018) The Military ACL. J Knee Surg 32:118–122 + + + Office of the Under Secretary of Defense, Personnel and Readiness. Population Representation in the Military Services: Fiscal Year 2018. Table D-12. Mean Age and Months of Completed Service of Active Component Enlisted Members, FYs 1973–2018;Table D-18. Mean Age and Completed Months of Service of Active Component Commissioned Officers, FYs 1973–2018; Published in 2020. + + + +
+ + + 36809510 + + 2023 + 02 + 22 + +
+ + 1433-7347 + + + 2023 + Feb + 21 + + + Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA + Knee Surg Sports Traumatol Arthrosc + + Balancing the flexion gap first in total knee arthroplasty leads to better preservation of posterior condylar offset resulting in better knee flexion. + 10.1007/s00167-023-07346-7 + + The purpose of this study is to determine whether the flexion first balancing technique, developed in an attempt to solve the dissatisfaction due to instability in total knee arthroplasties, leads to better restoration of joint line height and medial posterior condylar offset. This might result in better knee flexion, compared to the classic extension first gap balancing technique. The secondary objective is to show non-inferiority of the flexion first balancing technique in terms of clinical outcomes as measured by the Patient Reported Outcome Measurements. + A cohort of 40 patients (46 knee replacements) operated using the flexion first balancing technique was retrospectively analyzed and compared with a cohort of 51 patients (52 knee replacements) operated using the classic gap balancing technique. Radiographic analysis of the coronal alignment, joint line height and posterior condylar offset was performed. Clinical and functional outcome data were analyzed pre- and postoperatively and compared between both groups. The two sample t test, Mann-Whitney U test, Chi-square test and a linear mixed model were used for performing statistical analyses, after normality analyses were executed. + Radiologic evaluation showed a decrease in posterior condylar offset using the classic gap balancing technique (p = 0.040) versus no change using the flexion first balancing technique (p = n.s.). No statistically significant differences were noted for joint line height and coronal alignment. Using the flexion first balancer technique leads to a greater postoperative range of motion with deeper flexion (p = 0.002) and a better Knee injury and Osteoarthritis Outcome Score (KOOS) (p = 0.025). + The Flexion First Balancing technique is a valid and safe technique for TKA, resulting in better preservation of PCO with consequently greater postoperative flexion and better KOOS scores. + III. + © 2023. The Author(s) under exclusive licence to European Society of Sports Traumatology, Knee Surgery, Arthroscopy (ESSKA). + + + + Van de Kelft + An-Sofie + AS + http://orcid.org/0000-0002-9036-2296 + + Orthopedic Surgery, University of Ghent, Corneel Heyymanslaan 10, 9000, Ghent, Oost-Vlaanderen, Belgium. ansofie.vandekelft@ugent.be. + + + + De Mulder + Kris + K + + Orthopedic Department, AZ Nikolaas, Sint-Niklaas, Oost-Vlaanderen, Belgium. + + + + De Schepper + Jo + J + + Orthopedic Department, AZ Nikolaas, Sint-Niklaas, Oost-Vlaanderen, Belgium. + + + + Victor + Jan + J + + Orthopedic Department, UZGent, Ghent, Oost-Vlaanderen, Belgium. + + + + Vundelinckx + Bart + B + + Orthopedic Department, AZ Nikolaas, Sint-Niklaas, Oost-Vlaanderen, Belgium. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Knee Surg Sports Traumatol Arthrosc + 9314730 + 0942-2056 + + IM + + Clinical outcomes + Flexion + Flexion first balancing technique + Functional outcomes + PROMs + Posterior condylar offset + Total knee arthroplasty + +
+ + + + 2022 + 11 + 26 + + + 2023 + 02 + 09 + + + 2023 + 2 + 22 + 13 + 51 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809510 + 10.1007/s00167-023-07346-7 + 10.1007/s00167-023-07346-7 + + + + Bellemans J, Banks S, Victor J, Vandenneucker H, Moemans A (2002) Fluoroscopic analysis of the kinematics of deep flexion in total knee arthroplasty. Influence of posterior condylar offset. J Bone Joint Surg Br 84:50–53 + + 10.1302/0301-620X.84B1.0840050 + 11837832 + + + + Chang MJ, Kang SB, Chang CB, Han DH, Park HJ, Hwang K et al (2020) Posterior condylar offset changes and its effect on clinical outcomes after posterior-substituting, fixed-bearing total knee arthroplasty: anterior versus posterior referencing. Knee Surg Relat Res 32:10 + + 10.1186/s43019-019-0022-2 + 32660651 + 7219226 + + + + Christensen JC, Blackburn B, Browning B, Wilbur C, Trinity JD, Gililland JM et al (2022) Patient-reported outcomes measurement information system physical function and knee injury and osteoarthritis outcome score relationship on performance measures in people undergoing total knee arthroplasty. Disabil Rehabil. https://doi.org/10.1080/09638288.2022.21349341-9 + + 10.1080/09638288.2022.21349341-9 + 36255156 + + + + Churchill JL, Khlopas A, Sultan AA, Harwin SF, Mont MA (2018) Gap-balancing versus measured resection technique in total knee arthroplasty: a comparison study. J Knee Surg 31:13–16 + + 10.1055/s-0037-1608820 + 29179222 + + + + Freisinger GM, Hutter EE, Lewis J, Granger JF, Glassman AH, Beal MD et al (2017) Relationships between varus-valgus laxity of the severely osteoarthritic knee and gait, instability, clinical performance, and function. J Orthop Res 35:1644–1652 + + 10.1002/jor.23447 + 27664972 + + + + Goutham GDV, Jain VK, Sinha S, Arya RK (2020) Effect of posterior condylar offset in post operative range of motion in cruciate retaining and sacrificing TKR: a comparative analysis. J Orthop 20:342–346 + + 10.1016/j.jor.2020.06.012 + 32684670 + 7352049 + + + + Han HS, Kang SB (2018) Interactive effect of femoral posterior condylar offset and tibial posterior slope on knee flexion in posterior cruciate ligament-substituting total knee arthroplasty. Knee 25:335–340 + + 10.1016/j.knee.2018.02.001 + 29525547 + + + + Hasebe Y, Akasaka K, Yamamoto M (2021) Factors affecting early knee-flexion range of motion after total knee arthroplasty. J Phys Ther Sci 33:672–675 + + 10.1589/jpts.33.672 + 34539072 + 8436039 + + + + Kamenaga T, Hiranaka T, Okimura K, Fujishiro T, Okamoto K (2022) Contralateral knee flexion predicts postoperative knee flexion in unilateral total knee arthroplasty: a retrospective study. Orthop Traumatol Surg Res: OTSR 108:103218 + + 10.1016/j.otsr.2022.103218 + 35093564 + + + + Keenan OJF, Holland G, Maempel JF, Keating JF, Scott CEH (2020) Correlations between radiological classification systems and confirmed cartilage loss in severe knee osteoarthritis. Bone Joint J. 102-b:301–309 + + 10.1302/0301-620X.102B3.BJJ-2019-0337.R1 + 32114823 + + + + Koshire S, Mohanty SS, Keny SA, Rai AK, Rathod TN, Kamble P (2022) The influence of joint line restoration on functional outcome after primary total knee arthroplasty: a prospective study. J Clin Orthop Trauma 34:102023 + + 10.1016/j.jcot.2022.102023 + 36161062 + + + + Kwak DS, Kim YD, Cho N, In Y, Kim MS, Lim D et al (2022) Restoration of the joint line configuration reproduces native mid-flexion biomechanics after total knee arthroplasty: a matched-pair cadaveric study. Bioengineering 17:9 + + + Longo UG, Candela V, Pirato F, Hirschmann MT, Becker R, Denaro V (2021) Midflexion instability in total knee arthroplasty: a systematic review. Knee Surg Sports Traumatol Arthrosc 29:370–380 + + 10.1007/s00167-020-05909-6 + 32133537 + + + + Luyckx T, Vandenneucker H, Ing LS, Vereecke E, Ing AV, Victor J (2018) Raising the Joint Line in TKA is associated with mid-flexion laxity: a study in cadaver knees. Clin Orthop 476:601–611 + + 10.1007/s11999.0000000000000067 + 29443845 + 6260050 + + + + Matziolis G, Brodt S, Windisch C, Roehner E (2017) Changes of posterior condylar offset results in midflexion instability in single-radius total knee arthroplasty. Arch Orthop Trauma Surg 137:713–717 + + 10.1007/s00402-017-2671-5 + 28299431 + + + + Popat R, Albelooshi A, Mahapatra P, Bollars P, Ettinger M, Jennings S et al (2022) Improved joint line and posterior offset restoration in primary total knee replacement using a robotic-assisted surgical technique: an international multi-centre retrospective analysis of matched cohorts. PLoS ONE 17:e0272722 + + 10.1371/journal.pone.0272722 + 36006969 + 9409519 + + + + Ramkumar PN, Navarro SM, Haeberle HS, Ng M, Piuzzi NS, Spindler KP (2018) No difference in outcomes 12 and 24 months after lower extremity total joint arthroplasty: a systematic review and meta-analysis. J Arthroplasty 33:2322–2329 + + 10.1016/j.arth.2018.02.056 + 29567000 + + + + Stambough JB, Edwards PK, Mannen EM, Barnes CL, Mears SC (2019) Flexion instability after total knee arthroplasty. J Am Acad Orthop Surg 27:642–651 + + 10.5435/JAAOS-D-18-00347 + 30676514 + 6938456 + + + + Tapasvi SR, Shekhar A, Patil SS, Dipane MV, Chowdhry M, McPherson EJ (2020) Comparison of gap balancing vs measured resection technique in patients undergoing simultaneous bilateral total knee arthroplasty: one technique per knee. J Arthroplasty 35:732–740 + + 10.1016/j.arth.2019.10.002 + 31676174 + + + + Vajapey SP, Pettit RJ, Li M, Chen AF, Spitzer AI, Glassman AH (2020) Risk factors for mid-flexion instability after total knee arthroplasty: a systematic review. J Arthroplasty 35:3046–3054 + + 10.1016/j.arth.2020.05.026 + 32532482 + + + + van Lieshout WAM, Duijnisveld BJ, Koenraadt KLM, Elmans L, Kerkhoffs G, van Geenen RCI (2019) Adequate joint line restoration and good preliminary clinical outcomes after total knee arthroplasty using the Flexion First Balancer technique. Knee 26:794–802 + + 10.1016/j.knee.2019.04.002 + 31104812 + + + + van Lieshout WAM, Koenraadt KLM, Elmans L, van Geenen RCI (2020) Flexion First Balancer: description of new technique in TKA to reproduce joint line and pre-disease mechanical alignment. J Exp Orthop 7:23 + + 10.1186/s40634-020-00241-x + 32314101 + 7171040 + + + + van Lieshout WAM, van Oost I, Koenraadt KLM, Elmans L, van Geenen RCI (2021) The effect of restored medial knee anatomy in total knee arthroplasty with the flexion first balancer technique on mid-flexion laxity and functional outcome. BMC Musculoskelet Disord 22:1029 + + 10.1186/s12891-021-04869-3 + 34886819 + 8656087 + + + + Williams HA, Webster J, Teeter MG, Howard JL, Somerville LE, Lanting BA (2021) The impact of a gap balancing or measured resection surgical technique on posterior condylar offset and patient-reported outcome measures. Arthroplast Today 11:64–67 + + 10.1016/j.artd.2021.07.007 + 34471661 + 8387824 + + + + Yang G, Chen W, Chen W, Sun X, Zhou D, Chen S et al (2016) Full-thickness cartilage-based posterior femoral condylar offset. Influence on knee flexion after posterior-stabilized total knee arthroplasty. Orthop Traumatol Surg Res: OTSR 102:441–446 + + 10.1016/j.otsr.2016.02.011 + 27108259 + + + + Zhang Y, Wang J, Zhang M, Xu Y (2021) Effect of femoral posterior condyle offset on knee joint function after total knee replacement: a network meta-analysis and a sequential retrospective cohort study. J Orthop Surg Res 16:126 + + 10.1186/s13018-021-02233-8 + 33568164 + 7877059 + + + + +
+ + + 36809511 + + 2023 + 02 + 22 + +
+ + 1433-7347 + + + 2023 + Feb + 21 + + + Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA + Knee Surg Sports Traumatol Arthrosc + + Artificial intelligence bot ChatGPT in medical research: the potential game changer as a double-edged sword. + 10.1007/s00167-023-07355-6 + + + Dahmen + Jari + J + http://orcid.org/0000-0002-6849-1008 + + Department of Orthopaedic Surgery and Sports Medicine, Amsterdam Movement Sciences, Amsterdam UMC, Location AMC, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands. j.dahmen@amsterdamumc.nl. + + + Academic Center for Evidence Based Sports Medicine (ACES), Amsterdam, The Netherlands. j.dahmen@amsterdamumc.nl. + + + Amsterdam Collaboration for Health and Safety in Sports (ACHSS), International Olympic Committee (IOC) Research Center Amsterdam UMC, Amsterdam, The Netherlands. j.dahmen@amsterdamumc.nl. + + + + Kayaalp + M Enes + ME + + Department for Orthopaedics and Traumatology, Istanbul Kartal Dr. Lutfi Kirdar Training and Research Hospital, Istanbul, Turkey. + + + + Ollivier + Matthieu + M + + Aix Marseille Univ, CNRS, ISM, Inst Movement Sci, Marseille, France. + + + + Pareek + Ayoosh + A + + Sports Medicine and Shoulder Service, Department of Orthopedic Surgery, Hospital for Special Surgery, 535 East 70th Street, New York, NY, 10021, USA. + + + + Hirschmann + Michael T + MT + + Department of Orthopedic Surgery and Traumatology, Head Knee Surgery and DKF Head of Research, Kantonsspital Baselland, Bruderholz, 4101, Bottmingen, Switzerland. + + + + Karlsson + Jon + J + + Department for Orthopaedics, Sahlgrenska University Hospital, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden. + + + + Winkler + Philipp W + PW + + Department of Orthopaedics and Traumatology, Kepler University Hospital Linz, Linz, Austria. + + + + eng + + Editorial + + + 2023 + 02 + 21 + +
+ + Germany + Knee Surg Sports Traumatol Arthrosc + 9314730 + 0942-2056 + + IM + + Artificial intelligence + ChatGPT + Natural language processing + Plagiarism + +
+ + + + 2023 + 02 + 05 + + + 2023 + 02 + 10 + + + 2023 + 2 + 22 + 13 + 51 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809511 + 10.1007/s00167-023-07355-6 + 10.1007/s00167-023-07355-6 + + + + Gordijn B, Have HT (2023) ChatGPT: evolution or revolution? Med Health Care Philos. https://doi.org/10.1007/s11019-023-10136-0 + + 10.1007/s11019-023-10136-0 + 36656495 + + + + King MR (2023) A conversation on artificial intelligence, Chatbots, and plagiarism in higher education. Cell Mol Bioeng 16:1–2 + + 10.1007/s12195-022-00754-8 + 36660590 + + + + Zhavoronkov A (2022) Rapamycin in the context of Pascal’s Wager: generative pre-trained transformer perspective. Oncoscience 9:82–84 + + 10.18632/oncoscience.571 + 36589923 + 9796173 + + + + Thorp HH (2023) ChatGPT is fun, but not an author. Science 379:313 + + 10.1126/science.adg7879 + 36701446 + + + + Graham F (2023) Daily briefing: ChatGPT listed as author on research papers. Nature. https://doi.org/10.1038/d41586-023-00188-w + + 10.1038/d41586-023-00188-w + 36797517 + 9849126 + + + + Gao CA, Howard FM, Markov NS, Dyer EC, Ramesh S, Luo Y et al (2022) Comparing scientific abstracts generated by ChatGPT to original abstracts using an artificial intelligence output detector, plagiarism detector, and blinded human reviewers. Biorxiv. https://doi.org/10.1101/2022.12.23.5216102022.2012.2023.521610 + + 10.1101/2022.12.23.5216102022.2012.2023.521610 + 36561175 + 9709790 + + + + +
+ + + 36809512 + + 2023 + 02 + 22 + +
+ + 1433-7347 + + + 2023 + Feb + 21 + + + Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA + Knee Surg Sports Traumatol Arthrosc + + Femoral neck-shaft angle can predict the anterior capsular thickness in patients with femoracetabular impingement syndrome. + 10.1007/s00167-023-07347-6 + + To measure the femoral neck-shaft angle (NSA) on computed tomography (CT) images in femoracetabular impingement syndrome (FAIS) patients and explore its relationship with the anterior capsular thickness (ACT). + A retrospective review of prospectively collected data from 2022 was performed. Inclusion criteria included: primary hip surgery, 18 to 55 years of age, and CT imaging of the hips. Exclusion criteria included: revision hip surgery, mild or borderline hip dysplasia, hip synovitis, and incomplete radiographs and medical records. NSA was measured on CT imaging. ACT was measured using magnetic resonance imaging (MRI). Multiple linear regression was performed to assess the association between ACT and related variables, including age, sex, body mass index (BMI), lateral center-edge angle (LCEA), alpha angle, Beighton test score (BTS), and NSA. + A total of 150 patients were included. The mean age, BMI, and NSA were 35.8 ± 11.2 years, 22.8 ± 3.5, and 129.4° ± 7.7°, respectively. Eighty-five (56.7%) patients were females. Multivariable regression analysis revealed that NSA (P = 0.002) and sex (P = 0.001) were significantly negatively correlated with ACT. Age, BMI, LCEA angle, alpha angle, and BTS were not correlated with ACT. + This study confirmed that NSA significantly predicts ACT. A decrease in the NSA by 1° increases the ACT by 0.24 mm. + Level III. + © 2023. The Author(s) under exclusive licence to European Society of Sports Traumatology, Knee Surgery, Arthroscopy (ESSKA). + + + + Yang + Fan + F + + Department of Sports Medicine, Institute of Sports Medicine of Peking University, Peking University Third Hospital, Beijing, China. + + + Beijing Key Laboratory of Sports Injuries, Beijing, China. + + + Engineering Research Center of Sports Trauma Treatment Technology and Devices, Ministry of Education, Beijing, China. + + + + Zhang + Zhu + Z + + Department of Sports Medicine, Institute of Sports Medicine of Peking University, Peking University Third Hospital, Beijing, China. + + + Beijing Key Laboratory of Sports Injuries, Beijing, China. + + + Engineering Research Center of Sports Trauma Treatment Technology and Devices, Ministry of Education, Beijing, China. + + + + Zhang + Xin + X + + Department of Sports Medicine, Institute of Sports Medicine of Peking University, Peking University Third Hospital, Beijing, China. + + + Beijing Key Laboratory of Sports Injuries, Beijing, China. + + + Engineering Research Center of Sports Trauma Treatment Technology and Devices, Ministry of Education, Beijing, China. + + + + Huang + Hongjie + H + + Department of Sports Medicine, Institute of Sports Medicine of Peking University, Peking University Third Hospital, Beijing, China. bysyhhj@163.com. + + + Beijing Key Laboratory of Sports Injuries, Beijing, China. bysyhhj@163.com. + + + Engineering Research Center of Sports Trauma Treatment Technology and Devices, Ministry of Education, Beijing, China. bysyhhj@163.com. + + + + Wang + Jianquan + J + http://orcid.org/0000-0003-0504-7169 + + Department of Sports Medicine, Institute of Sports Medicine of Peking University, Peking University Third Hospital, Beijing, China. wjqsportsmed@163.com. + + + Beijing Key Laboratory of Sports Injuries, Beijing, China. wjqsportsmed@163.com. + + + Engineering Research Center of Sports Trauma Treatment Technology and Devices, Ministry of Education, Beijing, China. wjqsportsmed@163.com. + + + + eng + + + 82072403 + National Natural Science Foundation of China + + + + 81902205 + National Natural Science Foundation of China + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Knee Surg Sports Traumatol Arthrosc + 9314730 + 0942-2056 + + IM + + Anterior capsular thickness + Computed tomography + Femoral neck-shaft angle + Hip arthroscopy + Magnetic resonance imaging + +
+ + + + 2022 + 10 + 11 + + + 2023 + 02 + 09 + + + 2023 + 2 + 22 + 13 + 51 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809512 + 10.1007/s00167-023-07347-6 + 10.1007/s00167-023-07347-6 + + + + Bai H, Fu Y-Q, Ayeni OR, Yin Q-F (2023) The anterior hip capsule is thinner in dysplastic hips: a study comparing different young adult hip patients. Knee Surg Sports Traumatol Arthrosc 31(1):70–78 + + 10.1007/s00167-022-07022-2 + 35687148 + + + + Bhimani R, Ashkani-Esfahani S, Mirochnik K, Lubberts B, DiGiovanni CW, Tanaka MJ (2022) Radiographic landmarks for the femoral attachment of the medial patellofemoral complex: a cadaveric study. Arthroscopy 38:2504–2510 + + 10.1016/j.arthro.2022.01.046 + 35157967 + + + + Bizdikian AJ, Assi A, Bakouny Z, Yared F, Saghbini E, Bakhos GE et al (2018) Validity and reliability of different techniques of neck-shaft angle measurement. Clin Radiol 73:984.e981-984.e989 + + 10.1016/j.crad.2018.06.006 + + + + Boese CK, Dargel J, Oppermann J, Eysel P, Scheyerer MJ, Bredow J et al (2016) The femoral neck-shaft angle on plain radiographs: a systematic review. Skeletal Radiol 45:19–28 + + 10.1007/s00256-015-2236-z + 26305058 + + + + Curtis DM, Murray IR, Money AJ, Pullen WM, Safran MR (2022) Hip microinstability: understanding a newly defined hip pathology in young athletes. Arthroscopy 38:211–213 + + 10.1016/j.arthro.2021.12.001 + 35123704 + + + + Devitt BM, Smith BN, Stapf R, Tacey M, O’Donnell JM (2017) Generalized joint hypermobility is predictive of hip capsular thickness. Orthop J Sports Med 5:2325967117701882 + + 10.1177/2325967117701882 + 28451620 + 5400218 + + + + Gao G, Jiao C, Liu J, Zhou C, Liu Y, Ao Y et al (2022) Healing of joint capsule after hip arthroscopy using interportal capsulotomy and capsular closure influences clinical outcomes. J Orthop Surg Res 17:316 + + 10.1186/s13018-022-03208-z + 35705973 + 9202155 + + + + Haddad B, Hamdan M, Al Nawaiseh M, Aldowekat O, Alshrouf MA, Karam AM et al (2022) Femoral neck shaft angle measurement on plain radiography: is standing or supine radiograph a reliable template for the contralateral femur? BMC Musculoskelet Disord 23:1092 + + 10.1186/s12891-022-06071-5 + 36514028 + 9749307 + + + + Hu Y, Ying H, Yu D, Mao Y, Yan M, Li H et al (2022) Positive correlation between the femur neck shaft and anteversion angles: a retrospective computed tomography analysis in patients with developmental dysplasia of the hip. J Arthroplasty 37:538–543 + + 10.1016/j.arth.2021.12.013 + 34923094 + + + + Kay J, Memon M, Rubin S, Simunovic N, Nho SJ, Belzile EL et al (2020) The dimensions of the hip capsule can be measured using magnetic resonance imaging and may have a role in arthroscopic planning. Knee Surg Sports Traumatol Arthrosc 28:1246–1261 + + 10.1007/s00167-018-5162-5 + 30259148 + + + + Magerkurth O, Jacobson JA, Morag Y, Caoili E, Fessell D, Sekiya JK (2013) Capsular laxity of the hip: findings at magnetic resonance arthrography. Arthroscopy 29:1615–1622 + + 10.1016/j.arthro.2013.07.261 + 23993056 + + + + Ng KCG, Jeffers JRT, Beaulé PE (2019) Hip joint capsular anatomy, mechanics, and surgical management. J Bone Joint Surg Am 101:2141–2151 + + 10.2106/JBJS.19.00346 + 31800428 + + + + Ng KCG, Lamontagne M, Adamczyk AP, Rakhra KS, Rahkra KS, Beaulé PE (2015) Patient-specific anatomical and functional parameters provide new insights into the pathomechanism of cam FAI. Clin Orthop Relat Res 473:1289–1296 + + 10.1007/s11999-014-3797-1 + 25048279 + + + + Ng KCG, Mantovani G, Lamontagne M, Labrosse MR, Beaulé PE (2017) Increased hip stresses resulting from a cam deformity and decreased femoral neck-shaft angle during level walking. Clin Orthop Relat Res 475:998–1008 + + 10.1007/s11999-016-5038-2 + 27580734 + + + + Rakhra KS, Bonura AA, Nairn R, Schweitzer ME, Kolanko NM, Beaule PE (2016) Is the hip capsule thicker in diseased hips? Bone Joint Res 5:586–593 + + 10.1302/2046-3758.511.2000495 + 27903506 + 5133266 + + + + Siebenrock KA, Steppacher SD, Haefeli PC, Schwab JM, Tannast M (2013) Valgus hip with high antetorsion causes pain through posterior extraarticular FAI. Clin Orthop Relat Res 471:3774–3780 + + 10.1007/s11999-013-2895-9 + 23463288 + 3825876 + + + + Sun H, Huang H-J, Mamtimin M, Yang F, Duan Y-P, Zhang X et al (2022) Hip gluteus medius tears are associated with lower femoral neck-shaft angles and higher acetabular center-edge angles. Arthroscopy 38:1496–1505 + + 10.1016/j.arthro.2021.10.006 + 34678409 + + + + Tahoun MF, Lizano-Díez X, Soler BC, Pons MT (2022) Superior outcomes after arthroscopic treatment of femoroacetabular impingement and labral tears with closed versus open capsule. Knee Surg Sports Traumatol Arthrosc. https://doi.org/10.1007/s00167-022-07266-y + + 10.1007/s00167-022-07266-y + 36471028 + + + + van Klij P, Heijboer MP, Ginai AZ, Verhaar JAN, Waarsing JH, Agricola R (2021) Clinical and radiological hip parameters do not precede, but develop simultaneously with cam morphology: a 5-year follow-up study. Knee Surg Sports Traumatol Arthrosc 29:1401–1410 + + 10.1007/s00167-020-06282-0 + 33001216 + + + + Weber AE, Kuhns BD, Cvetanovich GL, Lewis PB, Mather RC, Salata MJ et al (2017) Does the hip capsule remain closed after hip arthroscopy with routine capsular closure for femoroacetabular impingement? A magnetic resonance imaging analysis in symptomatic postoperative patients. Arthroscopy 33:108–115 + + 10.1016/j.arthro.2016.07.022 + 27720303 + + + + +
+ + + 36809516 + + 2023 + 02 + 22 + +
+ + 2194-7236 + + 51 + 1 + + 2023 + Feb + 21 + + + Urolithiasis + Urolithiasis + + Ureteroscopic and flexible ureteroscopic lithotripsy: continuation or discontinuation of anticoagulant or antiplatelet drugs? A Chinese survey among urologists. + + 39 + + 10.1007/s00240-023-01413-x + + To evaluate the management of antithrombotic drugs made by different urologists before ureteroscopic lithotripsy and flexible ureteroscopy in stone patients undergoing active anticoagulant or antiplatelet therapy. + A survey was distributed to 613 urologists in China, which included personal work information and views on the management of anticoagulants (AC) or antiplatelet (AP) drugs during the perioperative period of ureteroscopic lithotripsy (URL) and flexible ureteroscopy (fURS). + 20.5% of urologists believed that AP drugs could be continued and 14.7% believed that AC drugs could be continued. 26.1% of the urologists who participated in more than 100 ureteroscopic lithotripsy or flexible ureteroscopy surgeries each year believed that AP drugs could be continued and 19.1% believed that AC drugs could be continued, compared with 13.6% (P < 0.01) and 9.2% (P < 0.01) of the urologists who performed less than 100 surgeries. Among the urologists with more than 20 cases undergoing active AC or AP therapy per year, 25.9% thought that AP drugs could be continued and 19.7% thought that AC drugs could be continued, compared with 17.1% (P = 0.008) and 11.5% (P = 0.005) of the urologists with less than 20 cases. + The decision on the continuation of AC or AP drugs before ureteroscopic and flexible ureteroscopic lithotripsy should be individualized. The experience in URL and fURS surgeries and in dealing with patients under AC or AP therapy is the influencing factor. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Xu + Zi-Jie + ZJ + + Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. + + + + Chen + Lei + L + + Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. + + + + Li + Deng + D + + Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. + + + + Xu + Chao-Liang + CL + + Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. + + + + Chen + Fei-Teng + FT + + Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. + + + + Tang + Qi-Lin + QL + + Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. + + + + Shao + Yi + Y + + Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. drshaoyi@163.com. + + + Shanghai Municipal Alliance in Urology, Shanghai, China. drshaoyi@163.com. + + + + eng + + + 20Y11904600 + Science and Technology Commission of Shanghai Municipality + + + + 2020PJD046 + Shanghai Pujiang Program + + + + 18sjkjgg13 + Science and Technology Commission of Songjiang District + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Urolithiasis + 101602699 + 2194-7228 + + IM + + Anticoagulant drugs antiplatelet drugs + Flexible ureteroscopy + Ureteroscopic lithotripsy + +
+ + + + 2022 + 10 + 01 + + + 2023 + 02 + 11 + + + 2023 + 2 + 22 + 13 + 51 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809516 + 10.1007/s00240-023-01413-x + 10.1007/s00240-023-01413-x + + + + Zeng G, Mai Z, Xia S, Wang Z, Zhang K, Wang L, Long Y, Ma J, Li Y, Wan SP, Wu W, Liu Y, Cui Z, Zhao Z, Qin J, Zeng T, Liu Y, Duan X, Mai X, Yang Z, Kong Z, Zhang T, Cai C, Shao Y, Yue Z, Li S, Ding J, Tang S, Ye Z (2017) Prevalence of kidney stones in China: an ultrasonography based cross-sectional study. BJU Int 120(1):109–116. https://doi.org/10.1111/bju.13828 + + 10.1111/bju.13828 + 28236332 + + + + Liu DY, He HC, Wang J, Tang Q, Zhou YF, Wang MW, Chu CL, Zhang CY, Zhu Y, Zhou WL, Shen ZJ (2012) Ureteroscopic lithotripsy using holmium laser for 187 patients with proximal ureteral stones. 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J Urol 168(2):442–445. https://doi.org/10.1016/s0022-5347(05)64654-x + + 10.1016/s0022-5347(05)64654-x + 12131284 + + + + Turna B, Stein RJ, Smaldone MC, Santos BR, Kefer JC, Jackman SV, Averch TD, Desai MM (2008) Safety and efficacy of flexible ureterorenoscopy and holmium:YAG lithotripsy for intrarenal stones in anticoagulated cases. J Urol 179(4):1415–1419. https://doi.org/10.1016/j.juro.2007.11.076 + + 10.1016/j.juro.2007.11.076 + 18289567 + + + + Aboumarzouk OM, Somani BK, Monga M (2012) Flexible ureteroscopy and holmium: YAG laser lithotripsy for stone disease in patients with bleeding diathesis: a systematic review of the literature. Int Braz J Urol 38(3):298–305 + + 10.1590/S1677-55382012000300002 + 22765861 + + + + Toepfer NJ, Baylor K, Henry Y, Simmons J, Berger PB (2013) The effect of antiplatelet and anticoagulant therapy on the clinical outcome of patients undergoing ureteroscopy. Urology 82(4):773–779. https://doi.org/10.1016/j.urology.2013.05.019 + + 10.1016/j.urology.2013.05.019 + 23876586 + + + + Elkoushy MA, Violette PD, Andonian S (2012) Ureteroscopy in patients with coagulopathies is associated with lower stone-free rate and increased risk of clinically significant hematuria. Int Braz J Urol 38(2):195–202 + + 10.1590/S1677-55382012000200007 + 22555043 + + + + Metersky ML, Nathanson I (2012) Introducing the future of ACCP clinical practice guidelines. 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J Endourol 30(10):1073–1078. https://doi.org/10.1089/end.2016.0447 + + 10.1089/end.2016.0447 + 27461936 + + + + Westerman ME, Scales JA, Sharma V, Gearman DJ, Ingimarsson JP, Krambeck AE (2017) The effect of anticoagulation on bleeding-related complications following ureteroscopy. Urology 100:45–52. https://doi.org/10.1016/j.urology.2016.09.034 + + 10.1016/j.urology.2016.09.034 + 27720775 + + + + Kaatz S, Paje D (2011) Update in bridging anticoagulation. J Thromb Thrombolysis 31(3):259–264. https://doi.org/10.1007/s11239-011-0571-z + + 10.1007/s11239-011-0571-z + 21327504 + + + + Klingler HC, Kramer G, Lodde M, Dorfinger K, Hofbauer J, Marberger M (2003) Stone treatment and coagulopathy. Eur Urol 43(1):75–79. https://doi.org/10.1016/s0302-2838(02)00538-9 + + 10.1016/s0302-2838(02)00538-9 + 12507547 + + + + Fenglin L, Taiping Z (2016) Guidelines for prevention and management of perioperative thrombus in Chinese general surgery [J]. 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+ + + 36809515 + + 2023 + 02 + 22 + +
+ + 1433-7347 + + + 2023 + Feb + 21 + + + Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA + Knee Surg Sports Traumatol Arthrosc + + Majority of competitive soccer players return to soccer following hip arthroscopy for femoroacetabular impingement: female and older aged players are less likely to return to soccer. + 10.1007/s00167-023-07349-4 + + To determine return to soccer rates and soccer performance in a large cohort of competitive soccer players after hip arthroscopic surgery for the treatment of femoroacetabular impingement (FAI) and to identify possible risk factors associated with not returning to soccer. + An institutional hip preservation registry was retrospectively reviewed for patients identified as competitive soccer players who underwent primary hip arthroscopy for FAI performed between 2010 and 2017. Patient demographics and injury characteristics as well as clinical and radiographic findings were recorded. All patients were contacted for return to soccer information using a soccer-specific return to play questionnaire. Multivariable logistic regression analysis was used to identify potential risk factors for not returning to soccer. + Eighty-seven competitive soccer players (119 hips) were included. 32 players (37%) underwent simultaneous or staged bilateral hip arthroscopy. The mean age at surgery was 21.6 ± 7.0 years. Overall, 65 players (74.7%) returned to soccer, of which 43 players (49% of all included players) returned to pre-injury level of play or better. Most common reasons for not returning to soccer were pain or discomfort (50%) followed by fear of re-injury (31.8%). The mean time to return to soccer was 33.1 ± 26.3 weeks. Among 22 players who did not return to soccer, 14 (63.6%) reported satisfaction from surgery. Multivariable logistic regression analysis revealed female players (odds ratio [OR] = 0.27; confidence interval [CI] = 0.083 to 0.872; p = 0.029) and older aged players (OR = 0.895; 95% CI = 0.832 to 0.963; p = 0.003) were less likely to return to soccer. Bilateral surgery was not found to be a risk factor. + Hip arthroscopic treatment for FAI in symptomatic competitive soccer players allowed three-quarters of them to return to soccer. Despite not returning to soccer, two-thirds of players who did not return to soccer were satisfied with their outcome. Female and older aged players were less likely to return to soccer. These data can better guide clinicians and soccer players with realistic expectations related to the arthroscopic management of symptomatic FAI. + III. + © 2023. The Author(s) under exclusive licence to European Society of Sports Traumatology, Knee Surgery, Arthroscopy (ESSKA). + + + + Marom + Niv + N + http://orcid.org/0000-0001-5393-6134 + + Department of Orthopaedic Surgery, Meir Medical Center, 59 Tcharnihovsky St, 4428164, Kfar Saba, Israel. niv.marom@gmail.com. + + + The Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. niv.marom@gmail.com. + + + + Olsen + Reena + R + + Sports Medicine Institute and Hip Preservation Service, Hospital for Special Surgery, New York, NY, USA. + + + + Burger + Joost A + JA + + Sports Medicine Institute, Hospital for Special Surgery, New York, NY, USA. + + + + Dooley + Matthew S + MS + + Sports Medicine Institute and Hip Preservation Service, Hospital for Special Surgery, New York, NY, USA. + + + + Coleman + Struan H + SH + + Sports Medicine Institute and Hip Preservation Service, Hospital for Special Surgery, New York, NY, USA. + + + + Ranawat + Anil S + AS + + Sports Medicine Institute and Hip Preservation Service, Hospital for Special Surgery, New York, NY, USA. + + + + Kelly + Bryan T + BT + + Sports Medicine Institute and Hip Preservation Service, Hospital for Special Surgery, New York, NY, USA. + + + + Nawabi + Danyal H + DH + + Sports Medicine Institute and Hip Preservation Service, Hospital for Special Surgery, New York, NY, USA. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Knee Surg Sports Traumatol Arthrosc + 9314730 + 0942-2056 + + IM + + Femoroacetabular impingement + Hip arthroscopy + Return to soccer + Return to sport + Soccer players + +
+ + + + 2022 + 08 + 13 + + + 2023 + 02 + 10 + + + 2023 + 2 + 22 + 13 + 51 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809515 + 10.1007/s00167-023-07349-4 + 10.1007/s00167-023-07349-4 + + + + Ardern CL, Glasgow P, Schneiders A, Witvrouw E, Clarsen B, Cools A, Gojanovic B, Griffin S, Khan KM, Moksnes H, Mutch SA, Phillips N, Reurink G, Sadler R, Silbernagel KG, Thorborg K, Wangensteen A, Wilk KE, Bizzini M (2016) 2016 Consensus statement on return to sport from the First World Congress in Sports Physical Therapy, Bern. Br J Sports Med 50:853–864 + + 10.1136/bjsports-2016-096278 + 27226389 + + + + Barastegui D, Seijas R, Alvarez-Diaz P, Rivera E, Alentorn-Geli E, Steinbacher G, Cuscó X, Cugat R (2018) Assessing long-term return to play after hip arthroscopy in football players evaluating risk factors for good prognosis. Knee Surg Sports Traumatol Arthrosc 26:963–968 + + 10.1007/s00167-017-4573-z + 28516234 + + + + Bolia IK, Ihn H, Kang HP, Mayfield CK, Briggs KK, Bedi A, Jay Nho S, Philippon MJ, Weber AE (2021) Cutting, impingement, contact, endurance, flexibility, and asymmetric/overhead sports: is there a difference in return-to-sport rate after arthroscopic femoroacetabular impingement surgery? A systematic review and meta-analysis. Am J Sports Med 49:1363–1371 + + 10.1177/0363546520950441 + 32909823 + + + + Clapp IM, Nwachukwu BU, Beck EC, Jan K, Gowd AK, Nho SJ (2020) Comparing outcomes of competitive athletes versus nonathletes undergoing hip arthroscopy for treatment of femoroacetabular impingement syndrome. Am J Sports Med 48:159–166 + + 10.1177/0363546519885359 + 31743036 + + + + D’Ambrosi R, Hantes ME, Mariani I, di Francia VP, della Rocca F (2021) Successful return to sport in patients with symptomatic borderline dysplasia following hip arthroscopy and T-shaped capsular plication. Knee Surg Sports Traumatol Arthrosc 29:1370–1377 + + 10.1007/s00167-020-06147-6 + 32691094 + + + + Davey MS, Hurley ET, Davey MG, Fried JW, Hughes AJ, Youm T, McCarthy T (2022) Criteria for return to play after hip arthroscopy in the treatment of femoroacetabular impingement: a systematic review. Am J Sports Med 50:3417–3424 + + 10.1177/03635465211038959 + 34591697 + + + + Fernandez CE, Morgan AM, Sheth U, Tjong VK, Terry MA (2020) Bilateral versus unilateral hip arthroscopy for femoroacetabular impingement: a systematic review. J Hip Preserv Surg 7:225–232 + + 10.1093/jhps/hnaa013 + 33163206 + 7605763 + + + + Frank RM, Lee S, Bush-Joseph CA, Salata MJ, Mather RC, Nho SJ (2016) Outcomes for hip arthroscopy according to sex and age: a comparative matched-group analysis. J Bone Joint Surg Am 98:797–804 + + 10.2106/JBJS.15.00445 + 27194489 + + + + Hale RF, Melugin HP, Zhou J, LaPrade MD, Bernard C, Leland D, Levy BA, Krych AJ (2021) Incidence of femoroacetabular impingement and surgical management trends over time. Am J Sports Med 49:35–41 + + 10.1177/0363546520970914 + 33226833 + + + + Hallberg S, Sansone M, Augustsson J (2020) Full recovery of hip muscle strength is not achieved at return to sports in patients with femoroacetabular impingement surgery. Knee Surg Sports Traumatol Arthrosc 28:1276 + + 10.1007/s00167-018-5337-0 + 30542743 + + + + Knapik DM, Gaudiani MA, Camilleri BE, Nho SJ, Voos JE, Salata MJ (2019) Reported prevalence of radiographic cam deformity based on sport: a systematic review of the current literature. Orthop J Sports Med 7:2325967119830873 + + 10.1177/2325967119830873 + 30915376 + 6429661 + + + + Kumar MV, Shanmugaraj A, Kay J, Simunovic N, Huang MJ, Wuerz TH, Ayeni OR (2021) Bilateral hip arthroscopy for treating femoroacetabular impingement: a systematic review. Knee Surg Sports Traumatol Arthrosc 30(3):1095–1108 + + 10.1007/s00167-021-06647-z + 34165631 + + + + Locks R, Utsunomiya H, Briggs KK, McNamara S, Chahla J, Philippon MJ (2017) Return to play after hip arthroscopic surgery for femoroacetabular impingement in professional soccer players. Am J Sports Med 46(2):273–279 + + 10.1177/0363546517738741 + 29135269 + + + + Maerz T, Nepple JJ, Bedi A, Zaltz I, Belzile É, Beaulé PE, Sink EL, Clohisy JC (2021) Sex differences in clinical outcomes following surgical treatment of femoroacetabular impingement. J Bone Joint Surg Am 103(5):415–423 + + 10.2106/JBJS.20.00394 + 33439607 + + + + Malviya A, Paliobeis CP, Villar RN (2013) Do professional athletes perform better than recreational athletes after arthroscopy for femoroacetabular impingement? Clin Orthop Relat Res 471(8):2477–2483 + + 10.1007/s11999-013-2787-z + 23456186 + 3705039 + + + + Malviya A, Stafford GH, Villar RN (2012) Is hip arthroscopy for femoroacetabular impingement only for athletes? Br J Sports Med 46:1016–1018 + + 10.1136/bjsports-2012-091184 + 22878258 + + + + Marom N, Dooley MS, Burger JA, Chang B, Coleman SH, Ranawat AS, Kelly BT, Nawabi DH (2020) Characteristics of soccer players undergoing primary hip arthroscopy for femoroacetabular impingement: a sex- and competitive level-specific analysis. Am J Sports Med 48:3255–3264 + + 10.1177/0363546520958697 + 32966110 + + + + Marom N, Xiang W, Wolfe I, Jivanelli B, Williams RJ, Marx RG (2021) High variability and lack of standardization in the evaluation of return to sport after ACL reconstruction: a systematic review. Knee Surg Sports Traumatol Arthrosc 30(4):1369–1379 + + 10.1007/s00167-021-06594-9 + 33978778 + + + + Memon M, Kay J, Hache P, Simunovic N, Harris JD, O’Donnell J, Ayeni OR (2019) Athletes experience a high rate of return to sport following hip arthroscopy. Knee Surg Sports Traumatol Arthrosc 27:3066–3104 + + 10.1007/s00167-018-4929-z + 29627931 + + + + Minkara AA, Westermann RW, Rosneck J, Lynch TS (2019) Systematic review and meta-analysis of outcomes after hip arthroscopy in femoroacetabular impingement. 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Arthroscopy 36(2):450–452 + + 10.1016/j.arthro.2019.10.012 + 32014176 + + + + Sansone M, Ahldén M, Jonasson P, Thomeé C, Swärd L, Baranto A, Karlsson J, Thomeé R (2015) Good results after hip arthroscopy for femoroacetabular impingement in top-level athletes. Orthop J Sports Med 3:1–8 + + 10.1177/2325967115569691 + + + + Schallmo MS, Fitzpatrick TH, Yancey HB, Marquez-Lara A, Luo TD, Stubbs AJ (2018) Return-to-play and performance outcomes of professional athletes in North America after hip arthroscopy from 1999 to 2016. Am J Sports Med 46:1959–1969 + + 10.1177/0363546518773080 + 29768026 + + + + Weber AE, Bolia IK, Mayfield CK, Ihn H, Kang HP, Bedi A, Nho SJ, Philippon MJ (2021) Can we identify why athletes fail to return to sport after hip arthroscopy for femoroacetabular impingement syndrome? A systematic review and meta-analysis. Am J Sports Med 49:1651–1658 + + 10.1177/0363546520956292 + 33017544 + + + + Wörner T, Thorborg K, Webster KE, Stålman A, Eek F (2021) Psychological readiness is related to return to sport following hip arthroscopy and can be assessed by the Hip-Return to Sport after Injury scale (Hip-RSI). Knee Surg Sports Traumatol Arthrosc 29:1353–1361 + + 10.1007/s00167-020-06157-4 + 32699920 + + + + Wörner T, Thorborg K, Webster KE, Stålman A, Eek F (2021) Return to sport after hip arthroscopy: are you ready? Knee Surg Sports Traumatol Arthrosc 29:1349–1352 + + 10.1007/s00167-021-06533-8 + 33786640 + + + + Zusmanovich M, Haselman W, Serrano B, Banffy M (2022) The incidence of hip arthroscopy in patients with femoroacetabular impingement syndrome and labral pathology increased by 85% between 2011 and 2018 in the United States. Arthroscopy 38:82–87 + + 10.1016/j.arthro.2021.04.049 + 33964383 + + + + +
+ + + 36809514 + + 2023 + 02 + 22 + +
+ + 1433-7347 + + + 2023 + Feb + 21 + + + Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA + Knee Surg Sports Traumatol Arthrosc + + Revision total knee arthroplasty for arthrofibrosis improves range of motion. + 10.1007/s00167-023-07353-8 + + Arthrofibrosis after primary total knee arthroplasty (TKA) is a significant contributor to patient dissatisfaction. While treatment algorithms involve early physical therapy and manipulation under anaesthesia (MUA), some patients ultimately require revision TKA. It is unclear whether revision TKA can consistently improve these patient's range of motion (ROM). The purpose of this study was to evaluate ROM when revision TKA was performed for arthrofibrosis. + A retrospective study of 42 TKA's diagnosed with arthrofibrosis from 2013 to 2019 at a single institution with a minimum 2-year follow-up was performed. The primary outcome was ROM (flexion, extension, and total arc of motion) before and after revision TKA, and secondary outcomes included patient reported outcomes information system (PROMIS) scores. Categorical data were compared using chi-squared analysis, and paired samples t tests were performed to compare ROM at three different times: pre-primary TKA, pre-revision TKA, and post-revision TKA. A multivariable linear regression analysis was performed to assess for effect modification on total ROM. + The patient's pre-revision mean flexion was 85.6 degrees, and mean extension was 10.1 degrees. At the time of the revision, the mean age of the cohort was 64.7 years, the average body mass index (BMI) was 29.8, and 62% were female. At a mean follow-up of 4.5 years, revision TKA significantly improved terminal flexion by 18.4 degrees (p < 0.001), terminal extension by 6.8 degrees (p = 0.007), and total arc of motion by 25.2 degrees (p < 0.001). The final ROM after revision TKA was not significantly different from the patient's pre-primary TKA ROM (p = 0.759). PROMIS physical function, depression, and pain interference scores were 39 (SD = 7.72), 49 (SD = 8.39), and 62 (SD = 7.25), respectively. + Revision TKA for arthrofibrosis significantly improved ROM at a mean follow-up of 4.5 years with over 25 degrees of improvement in the total arc of motion, resulting in final ROM similar to pre-primary TKA ROM. PROMIS physical function and pain scores showed moderate dysfunction, while depression scores were within normal limits. While physical therapy and MUA remain the gold standard for the early treatment of stiffness after TKA, revision TKA can improve ROM. + IV. + © 2023. The Author(s). + + + + Rockov + Zachary A + ZA + http://orcid.org/0000-0002-1181-3344 + + Department of Orthopaedic Surgery, Cedars-Sinai Medical Center, 444 South San Vicente Boulevard, Suite 603, Los Angeles, CA, 90048, USA. Zachary.Rockov@cshs.org. + + + + Byrne + Connor T + CT + + Department of Orthopaedic Surgery, Cedars-Sinai Medical Center, 444 South San Vicente Boulevard, Suite 603, Los Angeles, CA, 90048, USA. + + + + Rezzadeh + Kevin T + KT + + Department of Orthopaedic Surgery, Cedars-Sinai Medical Center, 444 South San Vicente Boulevard, Suite 603, Los Angeles, CA, 90048, USA. + + + + Durst + Caleb R + CR + + Department of Orthopaedic Surgery, Cedars-Sinai Medical Center, 444 South San Vicente Boulevard, Suite 603, Los Angeles, CA, 90048, USA. + + + + Spitzer + Andrew I + AI + + Department of Orthopaedic Surgery, Cedars-Sinai Medical Center, 444 South San Vicente Boulevard, Suite 603, Los Angeles, CA, 90048, USA. + + + + Paiement + Guy D + GD + + Department of Orthopaedic Surgery, Cedars-Sinai Medical Center, 444 South San Vicente Boulevard, Suite 603, Los Angeles, CA, 90048, USA. + + + + Penenberg + Brad L + BL + + Department of Orthopaedic Surgery, Cedars-Sinai Medical Center, 444 South San Vicente Boulevard, Suite 603, Los Angeles, CA, 90048, USA. + + + + Rajaee + Sean S + SS + + Department of Orthopaedic Surgery, Cedars-Sinai Medical Center, 444 South San Vicente Boulevard, Suite 603, Los Angeles, CA, 90048, USA. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Knee Surg Sports Traumatol Arthrosc + 9314730 + 0942-2056 + + IM + + Arthrofibrosis + Clinical outcomes + Complications + PROMIS + ROM + Revision total knee arthroplasty + Stiffness + rTKA + rTKR + +
+ + + + 2023 + 01 + 11 + + + 2023 + 02 + 10 + + + 2023 + 2 + 22 + 13 + 51 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809514 + 10.1007/s00167-023-07353-8 + 10.1007/s00167-023-07353-8 + + + + Abdul N, Dixon D, Walker A, Horabin J, Smith N, Weir DJ, Brewster NT, Deehan DJ, Mann DA, Borthwick LA (2015) Fibrosis is a common outcome following total knee arthroplasty. Sci Rep 5:16469 + + 10.1038/srep16469 + 26553967 + 4639721 + + + + Bingham JS, Bukowski BR, Wyles CC, Pareek A, Berry DJ, Abdel MP (2019) Rotating-Hinge revision total knee arthroplasty for treatment of severe arthrofibrosis. 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J Arthroplasty 32:2604–2611 + + 10.1016/j.arth.2017.02.005 + 28285897 + + + + Cohen JS, Gu A, Kapani N, Asadourian PA, Stake S, Quan T, Malahias MA, Sculco PK (2020) Efficacy of arthroscopic arthrolysis in the treatment of arthrofibrosis: a systematic review. J Knee Surg. https://doi.org/10.1055/s-0040-1709182 + + 10.1055/s-0040-1709182 + 32838459 + + + + Cohen JS, Gu A, Lopez NS, Park MS, Fehring KA, Sculco PK (2018) Efficacy of revision surgery for the treatment of stiffness after total knee arthroplasty: a systematic review. J Arthroplasty 33:3049–3055 + + 10.1016/j.arth.2018.04.036 + 29803577 + + + + Debbi EM, Alpaugh K, Driscoll DA, Tarity TD, Gkiatas I, Sculco PK (2021) Rotating Hinge revision total knee arthroplasty for severe arthrofibrosis. 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Knee 13:111–117 + + 10.1016/j.knee.2005.10.001 + 16490357 + + + + Zachwieja E, Perez J, Hardaker WM, Levine B, Sheth N (2018) Manipulation under anesthesia and stiffness after total knee arthroplasty. JBJS Rev 6:e2 + + 10.2106/JBJS.RVW.17.00113 + 29613867 + + + + +
+ + + 36809513 + + 2023 + 02 + 22 + +
+ + 1433-7347 + + + 2023 + Feb + 21 + + + Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA + Knee Surg Sports Traumatol Arthrosc + + Reactive arthritis following COVID-19: cause for concern. + 10.1007/s00167-023-07332-z + + Low-quality evidence suggests that COVID-19 may trigger reactive arthritis one to four weeks after the infection. Post COVID-19 reactive arthritis resolves within a few days, and no additional treatment is required. Established diagnostic or classification criteria for reactive arthritis are missing, and a deeper understanding of the immune mechanism related to COVID-19 prompt us to further investigate the immunopathogenic mechanisms capable of promoting or contrasting the development of specific rheumatic diseases. Caution should be exerted when managing post-infectious COVID-19 patient with arthralgia. + © 2023. The Author(s). + + + + Migliorini + Filippo + F + http://orcid.org/0000-0001-7220-1221 + + Department of Orthopaedic, Trauma, and Reconstructive Surgery, RWTH University Hospital, Pauwelsstraße 30, 52074, Aachen, Germany. migliorini.md@gmail.com. + + + Department of Orthopaedic and Trauma Surgery, Eifelklinik St. Brigida, 52152, Simmerath, Germany. migliorini.md@gmail.com. + + + + Karlsson + Jon + J + + Department of Orthopaedics, Sahlgrenska University Hospital, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden. + + + + Maffulli + Nicola + N + + Department of Medicine, Surgery and Dentistry, University of Salerno, 84081, Baronissi, Italy. + + + School of Pharmacy and Bioengineering, Faculty of Medicine, Keele University, ST4 7QB, Stoke On Trent, England. + + + Barts and the London School of Medicine and Dentistry, Centre for Sports and Exercise Medicine, Queen Mary University of London, Mile End Hospital, E1 4DG, London, England. + + + + eng + + Editorial + + + 2023 + 02 + 21 + +
+ + Germany + Knee Surg Sports Traumatol Arthrosc + 9314730 + 0942-2056 + + IM + + Covid + Musculoskeletal + Pandemic + Reactive arthritis + +
+ + + + 2023 + 01 + 14 + + + 2023 + 01 + 30 + + + 2023 + 2 + 22 + 13 + 51 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809513 + 10.1007/s00167-023-07332-z + 10.1007/s00167-023-07332-z + + + + Baimukhamedov C, Barskova T, Matucci-Cerinic M (2021) Arthritis after SARS-CoV-2 infection. Lancet Rheumatol 3:e324–e325 + + 10.1016/S2665-9913(21)00067-9 + 33748780 + 7963449 + + + + Basheikh M (2022) Reactive arthritis after COVID-19: a case report. Cureus 14:e24096 + + 35573487 + 9106556 + + + + Bordoni V, Sacchi A, Cimini E, Notari S, Grassi G, Tartaglia E et al (2020) An inflammatory profile correlates with decreased frequency of cytotoxic cells in coronavirus disease 2019. Clin Infect Dis 71:2272–2275 + + 10.1093/cid/ciaa577 + 32407466 + 7239202 + + + + Chen G, Wu D, Guo W, Cao Y, Huang D, Wang H et al (2020) Clinical and immunological features of severe and moderate coronavirus disease 2019. J Clin Invest 130:2620–2629 + + 10.1172/JCI137244 + 32217835 + 7190990 + + + + Cincinelli G, Di Taranto R, Orsini F, Rindone A, Murgo A, Caporali R (2021) A case report of monoarthritis in a COVID-19 patient and literature review: Simple actions for complex times. Medicine (Baltimore) 100:e26089 + + 10.1097/MD.0000000000026089 + 34114992 + + + + Coath FL, Mackay J, Gaffney JK (2021) Axial presentation of reactive arthritis secondary to COVID-19 infection. Rheumatology (Oxford) 60:e232–e233 + + 10.1093/rheumatology/keab009 + 33471106 + + + + Danssaert Z, Raum G, Hemtasilpa S (2020) Reactive arthritis in a 37-year-old female with SARS-CoV2 infection. Cureus 12:e9698 + + 32923288 + 7486113 + + + + Di Carlo M, Tardella M, Salaffi F (2021) Can SARS-CoV-2 induce reactive arthritis? Clin Exp Rheumatol 39(Suppl 128):25–26 + + 33506755 + + + + Dougados M, Baeten D (2011) Spondyloarthritis. Lancet 377:2127–2137 + + 10.1016/S0140-6736(11)60071-8 + 21684383 + + + + El Hasbani G, Jawad A, Uthman I (2021) Axial and peripheral spondyloarthritis triggered by sars-cov-2 infection: a report of two cases. Reumatismo 73:59–63 + + 10.4081/reumatismo.2021.1374 + 33874649 + + + + Fragata I, Mourao AF (2020) Coronavirus disease 19 (COVID-19) complicated with post-viral arthritis. Acta Reumatol Port 45:278–280 + + 33420769 + + + + Garcia LF (2020) Immune Response, inflammation, and the clinical spectrum of COVID-19. Front Immunol 11:1441 + + 10.3389/fimmu.2020.01441 + 32612615 + 7308593 + + + + Garcia-Kutzbach A, Chacon-Suchite J, Garcia-Ferrer H, Iraheta I (2018) Reactive arthritis: update 2018. Clin Rheumatol 37:869–874 + + 10.1007/s10067-018-4022-5 + 29455267 + + + + Gasparotto M, Framba V, Piovella C, Doria A, Iaccarino L (2021) Post-COVID-19 arthritis: a case report and literature review. Clin Rheumatol 40:3357–3362 + + 10.1007/s10067-020-05550-1 + 33587197 + 7882861 + + + + Gibson M, Sampat K, Coakley G (2020) A self-limiting symmetrical polyarthritis following COVID-19 infection. Rheum Adv Pract 4(rkaa052):014 + + + Honge BL, Hermansen MF, Storgaard M (2021) Reactive arthritis after COVID-19. BMJ Case Rep 14:e241375 + + 10.1136/bcr-2020-241375 + 33653867 + 7929821 + + + + Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y et al (2020) Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 395:497–506 + + 10.1016/S0140-6736(20)30183-5 + 31986264 + 7159299 + + + + Hyrich KL, Machado PM (2021) Rheumatic disease and COVID-19: epidemiology and outcomes. Nat Rev Rheumatol 17:71–72 + + 10.1038/s41584-020-00562-2 + 33339986 + + + + Jali I (2020) Reactive arthritis after COVID-19 infection. Cureus 12:e11761 + + 33409010 + 7779130 + + + + Kim PS, Klausmeier TL, Orr DP (2009) Reactive arthritis: a review. J Adolesc Health 44:309–315 + + 10.1016/j.jadohealth.2008.12.007 + 19306788 + + + + Kocyigit BF, Akyol A (2021) Reactive arthritis after COVID-19: a case-based review. Rheumatol Int 41:2031–2039 + + 10.1007/s00296-021-04998-x + 34550429 + 8456072 + + + + Koehler L, Kuipers JG, Zeidler H (2000) Managing seronegative spondarthritides. Rheumatology (Oxford) 39:360–368 + + 10.1093/rheumatology/39.4.360 + 10817767 + + + + Liew IY, Mak TM, Cui L, Vasoo S, Lim XR (2020) A Case of reactive arthritis secondary to coronavirus disease 2019 infection. J Clin Rheumatol 26:233 + + 10.1097/RHU.0000000000001560 + 32694352 + + + + McGonagle D, Sharif K, O’Regan A, Bridgewood C (2020) The role of cytokines including interleukin-6 in COVID-19 induced pneumonia and macrophage activation syndrome-like disease. Autoimmun Rev 19:102537 + + 10.1016/j.autrev.2020.102537 + 32251717 + 7195002 + + + + Mukarram IG, Mukarram MS, Ishaq K, Riaz SU (2020) Post COVID-19 reactive arthritis: an emerging existence in the spectrum of musculoskeletal complications of SARS-CoV-2 infection. J Clin Stud Med Case Rep 7:101 + + + Mukarram MS, IshaqGhauri M, Sethar S, Afsar N, Riaz A, Ishaq K (2021) COVID-19: an emerging culprit of inflammatory arthritis. Case Rep Rheumatol 2021:6610340 + + 33986966 + 8077721 + + + + Ono K, Kishimoto M, Shimasaki T, Uchida H, Kurai D, Deshpande GA et al (2020) Reactive arthritis after COVID-19 infection. RMD Open 6:e001350 + + 10.1136/rmdopen-2020-001350 + 32763956 + 7722270 + + + + Pal A, Roongta R, Mondal S, Sinha D, Sinhamahapatra P, Ghosh A et al (2022) Does post-COVID reactive arthritis exist? experience of a tertiary care centre with a review of the literature. Reumatol Clin. https://doi.org/10.1016/j.reuma.2022.03.004 + + 10.1016/j.reuma.2022.03.004 + 35578636 + 9096625 + + + + Parisi S, Borrelli R, Bianchi S, Fusaro E (2020) Viral arthritis and COVID-19. Lancet Rheumatol 2:e655–e657 + + 10.1016/S2665-9913(20)30348-9 + 33043303 + 7535796 + + + + Qin C, Zhou L, Hu Z, Zhang S, Yang S, Tao Y et al (2020) Dysregulation of immune response in patients with coronavirus 2019 (COVID-19) in Wuhan, China. Clin Infect Dis 71:762–768 + + 10.1093/cid/ciaa248 + 32161940 + + + + Saikali W, Gharib S (2021) The first non-radiographic axial spondyloarthrits with COVID-19. Immun Inflamm Dis 9:628–631 + + 10.1002/iid3.448 + 33979033 + 8239938 + + + + Salazar V, Jagger BW, Mongkolsapaya J, Burgomaster KE, Dejnirattisai W, Winkler ES et al (2019) Dengue and Zika virus cross-reactive human monoclonal antibodies protect against Spondweni virus infection and pathogenesis in mice. 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+ + + 36809519 + + 2023 + 02 + 22 + +
+ + 2042-7670 + + + 2023 + Feb + 21 + + + The Veterinary record + Vet Rec + + Associations between small ruminant lentivirus infection and total milk yield and somatic cell count in a dairy sheep flock. + + e2731 + + 10.1002/vetr.2731 + + Small ruminant lentiviruses (SRLVs) are lentiviruses of sheep and goats, formerly known as maedi-visna (MV) in sheep and caprine encephalitis and arthritis in goats. In sheep, SRLVs commonly cause progressive pneumonia, wasting and indurative mastitis. SRLVs have a long latent period, and chronic production losses are often not recognised until very late. Few studies quantifying the production losses in ewes have been published, and none have been published under UK flock husbandry conditions. + Production records of milk yield and somatic cell count (SCC) from a dairy flock of 319 milking East Friesian × Lacaune ewes identified as MV infected via routine serological screening for SRLV antibodies were used in multivariable linear regression modelling to estimate the impact of SRLV status on total milk yield and SCC. + Milk yield was reduced in seropositive ewes by 8.1%-9.2% over an entire lactation. SCC counts were not significantly different in SRLV-infected and unifected animals. + Further parameters, such as body condition score or clinical mastitis, that were not available may have clarified the underlying cause of milk yield drop. + The study demonstrates substantial production losses in an SRLV-affected flock and highlights the impact of the virus on a farm's economic viability. + © 2023 British Veterinary Association. + + + + Davies + Peers + P + + Department of Livestock & One Health, University of Liverpool, Liverpool, UK. + + + + Jones + Scott + S + + School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, UK. + + + + Dunham + Stephen + S + + School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, UK. + + + + Tarlinton + Rachael E + RE + https://orcid.org/0000-0003-3325-2311 + + School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, UK. + + + + eng + + + AHDB Beef and Lamb + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Vet Rec + 0031164 + 0042-4900 + + IM + + Maedi-Visna + milk + sheep + small ruminant lentivirus + +
+ + + + 2023 + 01 + 26 + + + 2022 + 09 + 23 + + + 2023 + 02 + 06 + + + 2023 + 2 + 22 + 13 + 52 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809519 + 10.1002/vetr.2731 + + + REFERENCES + + Gomez-Lucia E, Barquero N, Domenech A. Maedi-Visna virus: current perspectives. Vet Med. 2018;9:11-21. + + + Blacklaws BA, Berriatua E, Torsteinsdottir S, Watt NJ, De Andres D, Klein D, et al. Transmission of small ruminant lentiviruses. Vet Microbiol. 2004;101:199-208. + + + Michiels R, Van Mael E, Quinet C, Adjadj N, Cay A, De Regge N. Comparative analysis of different serological and molecular tests for the detection of small ruminant lentiviruses (SRLVs) in Belgian sheep and goats. Viruses. 2018;10:696. + + + Illius AW, Lievaart-Peterson K, McNeilly TN, Savill NJ. Epidemiology and control of Maedi-Visna virus: curing the flock. PLoS One. 2020;15:e0238781. + + + Ritchie C, Hosie B. Concern over Maedi Visna breakdowns. 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+ + + 36809518 + + 2023 + 02 + 22 + +
+ + 1573-4838 + + 34 + 2 + + 2023 + Feb + 21 + + + Journal of materials science. Materials in medicine + J Mater Sci Mater Med + + Study of nerve cell regeneration on nanofibers containing cerium oxide nanoparticles in a spinal cord injury model in rats. + + 9 + + 10.1007/s10856-023-06711-9 + + Since the CNS is unable to repair itself via neuronal regeneration in adult mammals, alternative therapies need to be found. The use of cerium oxide nanoparticles to repair nerve damage could be a promising approach for spinal cord reconstruction. In this study, we constructed a scaffold containing cerium oxide nanoparticles (Scaffold-CeO2) and investigated the rate of nerve cell regeneration in a rat model of spinal cord injury. The scaffold of gelatin and polycaprolactone was synthesized, and a gelatin solution containing cerium oxide nanoparticles was attached to the scaffold. For the animal study, 40 male Wistar rats were randomly divided into 4 groups (n = 10): (a) Control; (b) Spinal cord injury (SCI); (c) Scaffold (SCI + scaffold without CeO2 nanoparticles); (d) Scaffold-CeO2 (SCI + scaffold containing CeO2 nanoparticles). After creation of a hemisection SCI, scaffolds were placed at the site of injury in groups c and d, and after 7 weeks the rats were subjected to behavioral tests and then sacrificed for preparation of the spinal cord tissue to measure the expression of G-CSF, Tau and Mag proteins by Western blotting and Iba-1 protein by immunohistochemistry. The result of behavioral tests confirmed motor improvement and pain reduction in the Scaffold-CeO2 group compared to the SCI group. Decreased expression of Iba-1 and higher expression of Tau and Mag in the Scaffold-CeO2 group compared to the SCI group could be the result of nerve regeneration caused by the scaffold containing CeONPs as well as relief of pain symptoms. + © 2023. The Author(s). + + + + Rahimi + Behnaz + B + + Department of basic sciences, Saveh University of Medical Sciences, Saveh, Iran. + + + + Behroozi + Zahra + Z + + Department of basic sciences, Saveh University of Medical Sciences, Saveh, Iran. + + + Physiology Research Center, Institute of Neuropharmacology Kerman University of Medical Science, Kerman, Iran. + + + + Motamed + Ali + A + + Radiation Biology Research Center, Iran University of Medical Sciences, Tehran, Iran. + + + + Jafarpour + Maral + M + + International Campus, Iran University of Medical Sciences, Tehran, Iran. + + + + Hamblin + Michael R + MR + + Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, 2028, South Africa. + + + + Moshiri + Ali + A + + Dr. Moshiri Veterinary Clinic, Tehran, Iran. + + + + Janzadeh + Atousa + A + + Radiation Biology Research Center, Iran University of Medical Sciences, Tehran, Iran. atousajanzadeh@gmail.com. + + + + Ramezani + Fatemeh + F + + Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran. Ramezani.f@iums.ac.ir. + + + + eng + + + 97-4-32-13632 + iran university of medical sciences + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + J Mater Sci Mater Med + 9013087 + 0957-4530 + + IM +
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+ + + 36809522 + + 2023 + 02 + 22 + +
+ + 1573-7365 + + + 2023 + Feb + 21 + + + Metabolic brain disease + Metab Brain Dis + + Royal jelly improves learning and memory deficits in an amyloid β-induced model of Alzheimer's disease in male rats: Involvement of oxidative stress. + 10.1007/s11011-023-01168-9 + + Alzheimer's disease (AD) as the commonest type of dementia is associated with the cognitive function failure. Oxidative stress performs an essential role in the progression of AD. Royal jelly (RJ) is a natural product of bees with antioxidant and anti-inflammatory properties. The present research aimed to investigate the possible protective effect of RJ on learning and memory in a rat model of Aβ-induced AD. Forty male adult Wistar rats were equally distributed into five groups: control, sham-operated, Aβ (receiving intracerebroventricular (ICV) injection of amyloid beta (Aβ1-40)), Aβ + RJ 50 mg/kg, and Aβ + RJ 100 mg/kg. RJ was administered daily post-surgery by oral gavage for four weeks. Behavioral learning and memory were examined using the novel object recognition (NOR) and passive avoidance learning (PAL) tests. Also, oxidative stress markers, such as malondialdehyde (MDA), total oxidant status (TOS) and total antioxidant capacity (TAC), were assessed in the hippocampus. Aβ reduced step-through latency (STLr) and increased time spent in the dark compartment (TDC) in the PAL task and also decreased discrimination index in the NOR test. Administration of RJ ameliorated the Aβ-related memory impairment in both NOR and PAL tasks. Aβ decreased TAC and increased MDA and TOS levels in the hippocampus, whereas RJ administration reversed these Aβ-induced alterations. Our results indicated that RJ has the potential to ameliorate learning and memory impairment in the Aβ model of AD via attenuating oxidative stress. + © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. + + + + Raoufi + Safoura + S + http://orcid.org/0000-0002-4278-550X + + Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran. + + + Department of Physiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran. + + + + Salavati + Zahra + Z + + Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran. zahrasalavaty@gmail.com. + + + Department of Physiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran. zahrasalavaty@gmail.com. + + + + Komaki + Alireza + A + + Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran. + + + Department of Physiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran. + + + + Shahidi + Siamak + S + + Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran. + + + Department of Physiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran. + + + + Zarei + Mohammad + M + + Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran. + + + Department of Physiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran. + + + + eng + + + 9802241456 + Hamadan University of Medical Sciences + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Metab Brain Dis + 8610370 + 0885-7490 + + IM + + Alzheimer's disease + Amyloid β- peptide + Memory + Oxidative stress + Royal jelly + +
+ + + + 2022 + 05 + 26 + + + 2023 + 01 + 13 + + + 2023 + 2 + 22 + 13 + 52 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809522 + 10.1007/s11011-023-01168-9 + 10.1007/s11011-023-01168-9 + + + + Abramov AY, Canevari L, Duchen MR (2004) β-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase. J Neurosci 24(2):565–575 + + 14724257 + 6729998 + 10.1523/JNEUROSCI.4042-03.2004 + + + + Ahmad S, Campos MG, Fratini F, Altaye SZ, Li J (2020) New insights into the biological and pharmaceutical properties of royal jelly. Int J Mol Sci 21(2):382 + + 31936187 + 7014095 + 10.3390/ijms21020382 + + + + Ahmadi N, Safari S, Mirazi N, Karimi SA, Komaki A (2021) Effects of vanillic acid on Aβ1-40-induced oxidative stress and learning and memory deficit in male rats. 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+ + + 36809521 + + 2023 + 02 + 22 + +
+ + 1440-1681 + + + 2023 + Feb + 21 + + + Clinical and experimental pharmacology & physiology + Clin Exp Pharmacol Physiol + + Hsa_circ_0000591 drives osteosarcoma glycolysis and progression by sequestering miR-194-5p and elevating HK2 expression. + 10.1111/1440-1681.13763 + + Osteosarcoma (OS) is the most common bone tumor with a high risk of metastatic progression and recurrence after treatment. Circular RNA hsa_circ_0000591 (circ_0000591) plays a compelling role in OS aggressiveness. However, the function and regulatory mechanism of circ_0000591 need to be further elucidated. + As a subject of this study, a differential circRNA circ_0000591 was screened by circRNA microarray expression profiling (GSE96964). Expression changes of circ_0000591 were detected using real-time quantitative polymerase chain reaction (RT-qPCR). Effects of circ_0000591 silencing on OS cell viability, proliferation, colony formation, apoptosis, invasion, and glycolysis were determined via functional experiments. The mechanism by which circ_0000591 functions as a molecular sponge for miRNAs was predicted using bioinformatics analysis and validated using dual-luciferase reporter and RNA pull-down assays. Xenograft assay was done to validate the function of circ_0000591. + Circ_0000591 was strongly expressed in OS samples and cells. Silencing of circ_0000591 lessened cell viability, repressed cell proliferation, invasion, glycolysis, and promoted cell apoptosis. Importantly, circ_0000591 regulated HK2 expression by serving as a miR-194-5p molecular sponge. MiR-194-5p silencing impaired circ_0000591 downregulation-mediated suppression of OS cell malignancy and glycolysis. HK2 overexpression weakened the inhibiting impacts of miR-194-5p on OS cell malignancy and glycolysis. Also, circ_0000591 silencing decreased xenograft tumor growth in vivo. + Circ_0000591 drove OS glycolysis and growth by upregulating HK2 by sequestering miR-194-5p. The study highlighted the tumor-promoting function of circ_0000591 in OS. This article is protected by copyright. All rights reserved. + This article is protected by copyright. All rights reserved. + + + + Wang + Dawei + D + + Senior Department of Orthopedics, the Fourth Medical Center of PLA General Hospital, Beijing, China. + + + + Wang + Yang + Y + + Sanya Central Hospital (Hainan Third People's Hospital), Sanya, China. + + + + Wang + Huadong + H + + Senior Department of Orthopedics, the Fourth Medical Center of PLA General Hospital, Beijing, China. + + + + Yang + Yafeng + Y + + Senior Department of Orthopedics, the Fourth Medical Center of PLA General Hospital, Beijing, China. + + + + Li + Li + L + + Senior Department of Orthopedics, the Fourth Medical Center of PLA General Hospital, Beijing, China. + + + + Liu + Yihao + Y + + Senior Department of Orthopedics, the Fourth Medical Center of PLA General Hospital, Beijing, China. + + + + Yin + Xin + X + + Senior Department of Orthopedics, the Fourth Medical Center of PLA General Hospital, Beijing, China. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Australia + Clin Exp Pharmacol Physiol + 0425076 + 0305-1870 + + IM + + HK2 + circ_0000591 + miR-194-5p + osteosarcoma + sponge + +
+ + + + 2023 + 02 + 15 + + + 2022 + 08 + 19 + + + 2023 + 02 + 16 + + + 2023 + 2 + 22 + 13 + 52 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809521 + 10.1111/1440-1681.13763 + + +
+ + + 36809525 + + 2023 + 02 + 22 + +
+ + 1520-6505 + + + 2023 + Feb + 21 + + + Evolutionary anthropology + Evol Anthropol + + Twelfth annual meeting of the European Society for the Study of Human Evolution. + 10.1002/evan.21973 + + + Zastrow + Julia + J + + Paleoanthropology Working Group, Institute for Archaeological Sciences, Department of Geosciences, Eberhard Karls University of Tübingen, Tübingen, Germany. + + + + Affinito + Simona + S + + Paleoanthropology Working Group, Institute for Archaeological Sciences, DFG Center for Advanced Studies "Words, Bones, Genes, Tools", Department of Geosciences, Eberhard Karls University of Tübingen, Tübingen, Germany. + + + + Bader + Gregor D + GD + + Prehistory and Quaternary Ecology, Senckenberg Centre for Human Evolution and Palaeoenvironment, Department of Geosciences, Eberhard Karls University of Tübingen, Tübingen, Germany. + + + + Mentzer + Susan M + SM + http://orcid.org/0000-0002-3117-8448 + + Geoarchaeology Working Group, Institute for Archaeological Sciences, Senckenberg Centre for Human Evolution and Palaeoenvironment, Department of Geosciences, Eberhard Karls University of Tübingen, Tübingen, Germany. + + + + eng + + News + + + 2023 + 02 + 21 + +
+ + United States + Evol Anthropol + 9306331 + 1060-1538 + + IM +
+ + + + 2023 + 01 + 09 + + + 2023 + 01 + 27 + + + 2023 + 2 + 22 + 13 + 52 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809525 + 10.1002/evan.21973 + + +
+ + + 36809520 + + 2023 + 02 + 22 + +
+ + 1573-6571 + + + 2023 + Feb + 21 + + + Journal of religion and health + J Relig Health + + Effect of Spirituality-Based Palliative Care on Pain, Nausea, Vomiting, and the Quality of Life in Women with Colon Cancer: A Clinical Trial in Southern Iran. + 10.1007/s10943-023-01742-6 + + This randomized controlled clinical trial aimed to examine the effect of spirituality-based palliative care on pain, nausea, vomiting, and the quality of life in 80 Iranian colon cancer inpatients from January to June 2020 in southern Iran. Patients were randomly assigned to an intervention group and a control group. The intervention group took part in four 120-min sessions while the control group received standard care. Pain, nausea, vomiting, and quality of life were assessed before the intervention and one month after the intervention. Data were analyzed using paired t-test and independent t-test. Between-groups differences analysis showed a significant difference in the quality of life scores, pain score, as well as nausea and vomiting scores following the one-month intervention. In conclusion, this group spirituality-based palliative care intervention might be beneficial in improving quality of life and reducing symptoms. + © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. + + + + Sabet + Parisa + P + + Department of Medical Surgical Nursing, School of Nursing, Fasa University of Medical Sciences, Fasa, Iran. + + + + Karimi + Shahnaz + S + http://orcid.org/0000-0003-2438-5577 + + Department of Medical Education, Medical Education Research Center, Fasa University of Medical Sciences, Fasa, Iran. shahkar20022002@yahoo.co. + + + + Dehghan + Azizallah + A + + Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran. + + + + Bijani + Mostafa + M + + Department of Medical Surgical Nursing, School of Nursing, Fasa University of Medical Sciences, Fasa, Iran. + + + + eng + + + 97066 + fasa university of medical sciences + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + J Relig Health + 2985199R + 0022-4197 + + IM + + Cancer + Nausea + Pain + Palliative care + Quality of life + Spirituality + +
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Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA A Cancer Journal for Clinicians, 68(6), 394–424. https://doi.org/10.3322/caac.21262 + + 10.3322/caac.21262 + 30207593 + + + + Cleeland, C. (1991). Pain assessment in cancer. In: Effect of cancer on quality of life. (pp 296–305). CRC Press. + + + Eilami, O., Moslemirad, M., Naimi, E., Babuei, A., & Rezaei, K. (2019). The effect of religious psychotherapy emphasizing the importance of prayers on mental health and pain in cancer patients. Journal of Religion and Health, 58(2), 444–451. https://doi.org/10.1007/s10943-018-0696-x + + 10.1007/s10943-018-0696-x + 30225762 + + + + Fallahi, S., Rassouli, M., & Mojen, L. K. (2017). Cultural aspects of palliative cancer care in Iran. 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+ + + 36809517 + + 2023 + 02 + 22 + +
+ + 1573-2959 + + 195 + 3 + + 2023 + Feb + 21 + + + Environmental monitoring and assessment + Environ Monit Assess + + Aerobic granular sludge development using diatomite for low-strength wastewater treatment. + + 420 + + 10.1007/s10661-023-11028-9 + + This paper presents an assessment of the start-up performance of aerobic granular sludge (AGS) for the treatment of low-strength (chemical oxygen demand, COD < 200 mg/L) domestic wastewater by the application of a diatomite carrier. The feasibility was evaluated in terms of the start-up period and stability of the aerobic granules as well as COD and phosphate removal efficiencies. A single pilot-scale sequencing batch reactor (SBR) was used and operated separately for the control granulation and granulation with diatomite. Complete granulation (granulation rate ≥ 90%) was achieved within 20 days for the case of diatomite with an average influent COD concentration of 184 mg/L. In comparison, control granulation required 85 days to accomplish the same feat with a higher average influent COD concentration (253 mg/L). The presence of diatomite solidifies the core of the granules and enhances physical stability. AGS with diatomite recorded the strength and sludge volume index of 18 IC and 53 mL/g suspended solids (SS) which is superior to control AGS without diatomite (19.3 IC, 81 mL/g SS). Quick start-up and achievement of stable granules lead to an efficient COD (89%) and phosphate removal (74%) in 50 days of bioreactor operation. Interestingly, this study revealed that diatomite has some special mechanism in enhancing the removal of both COD and phosphate. Also, diatomite has a significant influence on microbial diversity. The result of this research implies that the advanced development of granular sludge by using diatomite can provide promising low-strength wastewater treatment. + © 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG. + + + + Basri + Hazlami Fikri + HF + http://orcid.org/0000-0002-3398-1832 + + Department of Water and Environmental Engineering, School of Civil Engineering, Faculty of Engineering, Universiti Teknologi Malaysia, 81310, Skudai, Johor, Malaysia. hazlami@utm.my. + + + + Anuar + Aznah Nor + AN + + Department of Environment and Green Technology, Malaysia-Japan International Institute of Technology (MJIIT), Universiti Teknologi Malaysia, Kuala Lumpur, Malaysia. + + + + Halim + Mohd Hakim Ab + MHA + + Department of Environment and Green Technology, Malaysia-Japan International Institute of Technology (MJIIT), Universiti Teknologi Malaysia, Kuala Lumpur, Malaysia. + + + + Yuzir + Muhammad Ali + MA + + Department of Environment and Green Technology, Malaysia-Japan International Institute of Technology (MJIIT), Universiti Teknologi Malaysia, Kuala Lumpur, Malaysia. + + + + Muda + Khalida + K + + Department of Water and Environmental Engineering, School of Civil Engineering, Faculty of Engineering, Universiti Teknologi Malaysia, 81310, Skudai, Johor, Malaysia. + + + + Omoregie + Armstrong Ighodalo + AI + + Department of Water and Environmental Engineering, School of Civil Engineering, Faculty of Engineering, Universiti Teknologi Malaysia, 81310, Skudai, Johor, Malaysia. + + + + Najib + Mohamed Zuhaili Mohamed + MZM + + Department of Water and Environmental Engineering, School of Civil Engineering, Faculty of Engineering, Universiti Teknologi Malaysia, 81310, Skudai, Johor, Malaysia. + + + + eng + + + R.K130000.7743.4J284 + Ministry of Education Malaysia + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Netherlands + Environ Monit Assess + 8508350 + 0167-6369 + + IM + + Aerobic granular sludge + Diatomite + Low-strength domestic wastewater + Pilot bioreactor + +
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Effects of lead concentration and accumulation on the performance and microbial community of aerobic granular sludge in sequencing batch reactors. Environmental Technology (united Kingdom), 37(22), 2905–2915. https://doi.org/10.1080/09593330.2016.1168870 + + 10.1080/09593330.2016.1168870 + + + + Van Leeuwe, M. A., Tedesco, L., Arrigo, K. R., Assmy, P., Campbell, K., Meiners, K. M., et al. (2018). Microalgal community structure and primary production in Arctic and Antarctic sea ice: A synthesis. Elementa, 6. https://doi.org/10.1525/elementa.267 + + + Wang, X., Chen, Z., Shen, J., Zhao, X., & Kang, J. (2019). Impact of carbon to nitrogen ratio on the performance of aerobic granular reactor and microbial population dynamics during aerobic sludge granulation. Bioresource Technology, 271, 258–265. https://doi.org/10.1016/j.biortech.2018.09.119 + + 10.1016/j.biortech.2018.09.119 + + + + Wang, Q., Jiang, L., Niu, H., Liang, J., Liu, Z., Arslan, M., et al. (2021). 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Rapid establishment and stable performance of a new algal-bacterial granule system from conventional bacterial aerobic granular sludge and preliminary analysis of mechanisms involved. Journal of Water Process Engineering, 34. https://doi.org/10.1016/j.jwpe.2019.101073 + + 10.1016/j.jwpe.2019.101073 + + + + Zhang, Y., Dong, X., Nuramkhaan, M., Lei, Z., Shimizu, K., Zhang, Z., et al. (2019). Rapid granulation of aerobic granular sludge: A mini review on operation strategies and comparative analysis. Bioresource Technology Reports, 7. https://doi.org/10.1016/J.BITEB.2019.100206 + + 10.1016/J.BITEB.2019.100206 + + + + Zhang, W., Rao, P., Zhang, H., & Xu, J. (2009). The role of diatomite particles in the activated sludge system for treating coal gasification wastewater. Chinese Journal of Chemical Engineering, 17(1), 167–170. https://doi.org/10.1016/S1004-9541(09)60050-1 + + 10.1016/S1004-9541(09)60050-1 + + + + Zhang, B., Wang, X., Li, S., Liu, Y., An, Y., & Zheng, X. (2019). Preferable adsorption of nitrogen and phosphorus from agricultural wastewater using thermally modified zeolite-diatomite composite adsorbent. Water (Switzerland), 11(10). https://doi.org/10.3390/w11102053 + + 10.3390/w11102053 + + + + Zhou, J. H., Zhao, H., Hu, M., Yu, H. T., Xu, X. Y., Vidonish, J., et al. (2015). Granular activated carbon as nucleating agent for aerobic sludge granulation: Effect of GAC size on velocity field differences (GAC versus flocs) and aggregation behavior. Bioresource Technology, 198, 358–363. https://doi.org/10.1016/j.biortech.2015.08.155 + + 10.1016/j.biortech.2015.08.155 + + + + Zou, J., Pan, J., Wu, S., Qian, M., He, Z., Wang, B., & Li, J. (2019). Rapid control of activated sludge bulking and simultaneous acceleration of aerobic granulation by adding intact aerobic granular sludge. Science of the Total Environment, 674, 105–113. https://doi.org/10.1016/j.scitotenv.2019.04.006 + + 10.1016/j.scitotenv.2019.04.006 + + + + +
+ + + 36809524 + + 2023 + 02 + 22 + +
+ + 1573-7365 + + + 2023 + Feb + 21 + + + Metabolic brain disease + Metab Brain Dis + + Bioinformatics investigation on blood-based gene expressions of Alzheimer's disease revealed ORAI2 gene biomarker susceptibility: An explainable artificial intelligence-based approach. + 10.1007/s11011-023-01171-0 + + The progressive, chronic nature of Alzheimer's disease (AD), a form of dementia, defaces the adulthood of elderly individuals. The pathogenesis of the condition is primarily unascertained, turning the treatment efficacy more arduous. Therefore, understanding the genetic etiology of AD is essential to identifying targeted therapeutics. This study aimed to use machine-learning techniques of expressed genes in patients with AD to identify potential biomarkers that can be used for future therapy. The dataset is accessed from the Gene Expression Omnibus (GEO) database (Accession Number: GSE36980). The subgroups (AD blood samples from frontal, hippocampal, and temporal regions) are individually investigated against non-AD models. Prioritized gene cluster analyses are conducted with the STRING database. The candidate gene biomarkers were trained with various supervised machine-learning (ML) classification algorithms. The interpretation of the model prediction is perpetrated with explainable artificial intelligence (AI) techniques. This experiment revealed 34, 60, and 28 genes as target biomarkers of AD mapped from the frontal, hippocampal, and temporal regions. It is identified ORAI2 as a shared biomarker in all three areas strongly associated with AD's progression. The pathway analysis showed that STIM1 and TRPC3 are strongly associated with ORAI2. We found three hub genes, TPI1, STIM1, and TRPC3, in the network of the ORAI2 gene that might be involved in the molecular pathogenesis of AD. Naive Bayes classified the samples of different groups by fivefold cross-validation with 100% accuracy. AI and ML are promising tools in identifying disease-associated genes that will advance the field of targeted therapeutics against genetic diseases. + © 2023. The Author(s). + + + + Sekaran + Karthik + K + + Laboratory of Integrative Genomics, Department of Integrative Biology, School of BioSciences and Technology, Vellore Institute of Technology (VIT), Vellore, 632014, Tamil Nadu, India. + + + + Alsamman + Alsamman M + AM + + Department of Genome Mapping, Molecular Genetics and Genome Mapping Laboratory, Agricultural Genetic Engineering Research Institute, Giza, Egypt. + + + + George Priya Doss + C + C + + Laboratory of Integrative Genomics, Department of Integrative Biology, School of BioSciences and Technology, Vellore Institute of Technology (VIT), Vellore, 632014, Tamil Nadu, India. georgepriyadoss@vit.ac.in. + + + + Zayed + Hatem + H + http://orcid.org/0000-0001-8838-6638 + + Department of Biomedical Sciences College of Health Sciences, QU Health, Qatar University, Doha, Qatar. hatem.zayed@qu.edu.qa. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Metab Brain Dis + 8610370 + 0885-7490 + + IM + + Alzheimer's + Artificial Intelligence + Biomarkers + Genetic Algorithm + Machine Learning + ORAI2 + STIM2 + +
+ + + + 2022 + 11 + 07 + + + 2023 + 01 + 16 + + + 2023 + 2 + 22 + 13 + 52 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809524 + 10.1007/s11011-023-01171-0 + 10.1007/s11011-023-01171-0 + + + References + + Al-Thani HF, Ahmad MN, Younes S, Zayed H (2021) Genetic variants associated with alzheimer disease in the 22 arab countries: A systematic review. Alzheimer Dis Assoc Disord 35(2):178–186 + + 10.1097/WAD.0000000000000447 + 33769987 + + + + Antoniadi AM, Du Y, Guendouz Y, Wei L, Mazo C, Becker BA, Mooney C (2021) Current challenges and future opportunities for XAI in machine learning-based clinical decision support systems: a systematic review. Appl Sci 11(11):5088 + + 10.3390/app11115088 + + + + Bagabir, S., Ibrahim, N. K., Bagabir, H., & Ateeq, R. (2022). Covid-19 and artificial intelligence: Genome sequencing, drug development and vaccine discovery. 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+ + + 36809523 + + 2023 + 02 + 22 + +
+ + 1573-7365 + + + 2023 + Feb + 21 + + + Metabolic brain disease + Metab Brain Dis + + Celastrus paniculatus oil ameliorates NF-KB mediated neuroinflammation and synaptic plasticity in the scopolamine-induced cognitive impairment rat model. + 10.1007/s11011-023-01186-7 + + Traditionally, Celastrus paniculatus Willd. (CP) oil has been utilized as a tranquilizer and memory enhancer. The present study investigated the neuropharmacological activity and efficacy of CP oil in ameliorating scopolamine-induced cognitive impairment in rats. + Cognitive deficiency was induced in rats by administration of scopolamine (2 mg/kg intraperitoneal injection) for a period of 15 days. Donepezil served as a reference drug and CP oil was tested as both preventive and curative treatments. Animals' behaviour was assessed through the Morris water maze (MWM), novel object preference (NOR), and conditioned avoidance (CA) tests. Oxidative stress parameters, bioamine concentration (dopamine, noradrenaline, and 5-hydroxytryptamine), nerve growth factor (NGF), interleukin-6 (IL-6), nuclear factor kappa B (NF-кB), and tumor necrosis factor-alpha (TNFα) were estimated. Synaptophysin immunohistochemistry was performed. + Our results showed that CP oil ameliorated behavioural deficits. It reduced latency to find a hidden platform in MWM. Reduced novel object exploration time and discrimination index (p < 0.05) in the NOR. Reduced step-down latency and normalized conditioned avoidance response (p < 0.001) in the CA test. CP oil increased dopamine, serotonin, norepinephrine, superoxide dismutase (SOD), glutathione, and catalase levels. It decreased malondialdehyde (MDA), acetylcholinesterase activity, IL-6, NF-кB (P < 0.001), TNFα, and NGF levels. Treatment showed approximate typical reactivity to synaptophysin. + Our data is suggestive that CP oil treatment improves behavioural test outcomes, increases biogenic amine concentration, and decreases acetylcholinesterase activity, and neuroinflammatory biomarkers. It also restores synaptic plasticity. It thus improves cognitive functions against scopolamine-induced amnesia in rats by improving cholinergic function. + © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. + + + + Faldu + Khushboo Govind + KG + http://orcid.org/0000-0002-2355-938X + + Department of Pharmacology, Institute of Pharmacy, Nirma University, Sarkhej - Gandhinagar Hwy, 382481, Gota, Ahmedabad, Gujarat, India. + + + + Patel + Snehal Sanjay + SS + + Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, India. + + + + Shah + Jigna Samir + JS + http://orcid.org/0000-0001-9722-4526 + + Department of Pharmacology, Institute of Pharmacy, Nirma University, Sarkhej - Gandhinagar Hwy, 382481, Gota, Ahmedabad, Gujarat, India. jigna.shah@nirmauni.ac.in. + + + + eng + + + GUJCOST/MRP/2014-15/2592 + Gujarat Council for Science and Technology + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Metab Brain Dis + 8610370 + 0885-7490 + + IM + + Acetylcholinesterase activity + Alzheimer’s disease + Biogenic amines + Cognition + Nerve growth factor + Neuroinflammation + Oxidative stress + Synaptophysin + +
+ + + + 2022 + 10 + 10 + + + 2023 + 02 + 13 + + + 2023 + 2 + 22 + 13 + 52 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809523 + 10.1007/s11011-023-01186-7 + 10.1007/s11011-023-01186-7 + + + + Abdelghany AK, El-Nahass ES, Ibrahim MA et al (2022) Neuroprotective role of medicinal plant extracts evaluated in a scopolamine-induced rat model of Alzheimer. https://doi.org/10.1080/1354750X.2022.2112975 . ’s diseasehttps://doi.org/101080/1354750X20222112975 + + + Ademosun AO, Adebayo AA, Popoola TV, Oboh G (2020) Shaddock (Citrus maxima) peels extract restores cognitive function, cholinergic and purinergic enzyme systems in scopolamine-induced amnesic rats. Drug Chem Toxicol 0:1–8. https://doi.org/10.1080/01480545.2020.1808668 + + 10.1080/01480545.2020.1808668 + + + + Aleem M (2021) Phytochemistry and pharmacology of Celastrus paniculatus Wild.: a nootropic drug. J Complement Integr Med. https://doi.org/10.1515/JCIM-2021-0251/MACHINEREADABLECITATION/RIS + + 10.1515/JCIM-2021-0251/MACHINEREADABLECITATION/RIS + 34529902 + + + + Alzheimer’s Association R (2021) 2021 Alzheimer’s disease facts and figures. Alzheimer’s Dement 17:327–406. https://doi.org/10.1002/alz.12328 + + 10.1002/alz.12328 + + + + Bhanumathy M, Harish MS, Shivaprasad HN, Sushma G (2010) Nootropic activity of Celastrus paniculatus seed. Pharm Biol 48:324–327. https://doi.org/10.3109/13880200903127391 + + 10.3109/13880200903127391 + 20645820 + + + + Bhattarai P, Cosacak MI, Mashkaryan V et al (2020) Neuron-glia interaction through Serotonin-BDNF-NGFR axis enables regenerative neurogenesis in Alzheimer’s model of adult zebrafish brain. PLoS Biol 18:1–27. https://doi.org/10.1371/journal.pbio.3000585 + + 10.1371/journal.pbio.3000585 + + + + Blokland A (2022) Cholinergic models of memory impairment in animals and man: scopolamine vs. biperiden. Behav Pharmacol 33:231–237. https://doi.org/10.1097/FBP.0000000000000670 + + 10.1097/FBP.0000000000000670 + 35621168 + + + + Boligon AA, de Freitas RB, de Brum TF et al (2014) Antiulcerogenic activity of Scutia buxifolia on gastric ulcers induced by ethanol in rats. Acta Pharm Sin B 4:358–367. https://doi.org/10.1016/j.apsb.2014.05.001 + + 10.1016/j.apsb.2014.05.001 + 26579405 + 4629092 + + + + Brandeis R, Brandys Y, Yehuda S (1989) The use of the Morris water maze in the study of memory and learning. Int J Neurosci 48:29–69. https://doi.org/10.3109/00207458909002151 + + 10.3109/00207458909002151 + 2684886 + + + + Chakrabarty M, Bhat P, Kumari S et al (2012) Cortico-hippocampal salvage in chronic aluminium induced neurodegeneration by Celastruspaniculatus seed oil: neurobehavioural, biochemical, histological study. J Pharmacol Pharmacother 3:161–171. https://doi.org/10.4103/0976-500X.95520 + + 10.4103/0976-500X.95520 + 22629092 + 3356958 + + + + Chalermpalanupap T, Kinkead B, Hu WT et al (2013) Targeting norepinephrine in mild cognitive impairment and Alzheimer’s disease. Alzheimer’s Res Ther. https://doi.org/10.1186/alzrt175 . 5: + + 10.1186/alzrt175 + + + + Chan KW, Chin VK, Ismail N et al (2022) Biological activities and therapeutic effects of Celastrus paniculatus seed oil. Mult Biol Act Unconv Seed Oils 29–41. https://doi.org/10.1016/B978-0-12-824135-6.00024-6 + + + Cheon SY, Koo BN, Kim SY et al (2021) Scopolamine promotes neuroinflammation and delirium-like neuropsychiatric disorder in mice. Sci Rep 2021 111 11:1–13. https://doi.org/10.1038/s41598-021-87790-y + + 10.1038/s41598-021-87790-y + + + + Deture MA, Dickson DW (2019) The neuropathological diagnosis of Alzheimer’s disease. 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CNS Neurol Disord Drug Targets 13:684–690 + + 10.2174/1871527313666140618105404 + 24938777 + + + + Faldu KG, Shah JS (2022) Alzheimer’s disease: a scoping review of biomarker research and development for effective disease diagnosis. 22:681–703. https://doi.org/10.1080/14737159.2022.2104639 + + + Faldu, Patel SS, Shah JS (2021) Celastrus paniculatus oil ameliorates synaptic plasticity in a rat model of attention deficit hyperactivity disorder. Asian Pac J Trop Biomed 11:105. https://doi.org/10.4103/2221-1691.306690 + + 10.4103/2221-1691.306690 + + + + Falsafi SK, Deli A, Höger H et al (2012) Scopolamine administration modulates muscarinic, nicotinic and NMDA receptor systems. PLoS ONE 7:e32082. https://doi.org/10.1371/journal.pone.0032082 + + 10.1371/journal.pone.0032082 + 22384146 + 3285663 + + + + Farooqui AA (2019) Potential treatment strategies of Dementia with Ayurvedic Medicines. Mol Mech Dement 287–328. https://doi.org/10.1016/B978-0-12-816347-4.00009-X + + + Gattu M, Boss KL, Terry AV, Buccafusco JJ (1997) Reversal of scopolamine-induced deficits in navigational memory performance by the seed oil of Celastrus paniculatus. Pharmacol Biochem Behav 57:793–799. https://doi.org/10.1016/S0091-3057(96)00391-7 + + 10.1016/S0091-3057(96)00391-7 + 9259008 + + + + Giovannini MG, Spignoli G, Carla V, Pepeu G (1991) A decrease in brain catecholamines prevents oxiracetam antagonism of the effects of scopolamine on memory and brain acetylcholine. Pharmacol Res 24:395–405. https://doi.org/10.1016/1043-6618(91)90044-X + + 10.1016/1043-6618(91)90044-X + 1805193 + + + + Godkar PB, Gordon RK, Ravindran A, Doctor BP (2006) Celastrus paniculatus seed oil and organic extracts attenuate hydrogen peroxide- and glutamate-induced injury in embryonic rat forebrain neuronal cells. Phytomedicine 13:29–36. https://doi.org/10.1016/j.phymed.2003.11.011 + + 10.1016/j.phymed.2003.11.011 + 16360930 + + + + Gutierres JM, Carvalho FB, Schetinger MRC et al (2014) Neuroprotective effect of anthocyanins on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia in rats. Int J Dev Neurosci 33:88–97. https://doi.org/10.1016/j.ijdevneu.2013.12.006 + + 10.1016/j.ijdevneu.2013.12.006 + 24374256 + + + + Ivanova N, Liu Q, Agca C et al (2020) White matter inflammation and cognitive function in a co-morbid metabolic syndrome and prodromal Alzheimer’s disease rat model. J Neuroinflammation 17:1–18. https://doi.org/10.1186/s12974-020-1698-7 + + 10.1186/s12974-020-1698-7 + + + + Jadhav K, Marathe P, Rege N et al (2015) Effect of Jyotiṣmatī seed oil on spatial and fear memory using scopolamine induced amnesia in mice. 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+ + + 36809526 + + 2023 + 02 + 22 + +
+ + 1932-6203 + + 18 + 2 + + 2023 + + + PloS one + PLoS One + + The extent of algorithm aversion in decision-making situations with varying gravity. + + e0278751 + + 10.1371/journal.pone.0278751 + + Algorithms already carry out many tasks more reliably than human experts. Nevertheless, some subjects have an aversion towards algorithms. In some decision-making situations an error can have serious consequences, in others not. In the context of a framing experiment, we examine the connection between the consequences of a decision-making situation and the frequency of algorithm aversion. This shows that the more serious the consequences of a decision are, the more frequently algorithm aversion occurs. Particularly in the case of very important decisions, algorithm aversion thus leads to a reduction of the probability of success. This can be described as the tragedy of algorithm aversion. + Copyright: © 2023 Filiz et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Filiz + Ibrahim + I + + Faculty of Business, Ostfalia University of Applied Sciences, Wolfsburg, Germany. + + + + Judek + Jan René + JR + + Faculty of Business, Ostfalia University of Applied Sciences, Wolfsburg, Germany. + + + + Lorenz + Marco + M + https://orcid.org/0000-0001-9254-1223 + + Faculty of Economic Sciences, Georg August University Göttingen, Göttingen, Germany. + + + + Spiwoks + Markus + M + + Faculty of Business, Ostfalia University of Applied Sciences, Wolfsburg, Germany. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2021 + 12 + 17 + + + 2022 + 11 + 15 + + + 2023 + 2 + 22 + 13 + 52 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809526 + 10.1371/journal.pone.0278751 + PONE-D-21-39459 + + +
+ + + 36809527 + + 2023 + 02 + 22 + +
+ + 1932-6203 + + 18 + 2 + + 2023 + + + PloS one + PLoS One + + Adaptive and non-adaptive gene expression responses in prostate cancer during androgen deprivation. + + e0281645 + + 10.1371/journal.pone.0281645 + + Androgen deprivation therapy is the cornerstone treatment of advanced prostate cancer. Eventually prostate cancer cells overcome androgen deprivation therapy, giving rise to castration resistant prostate cancer (CRPC) characterized by increased androgen receptor (AR) activity. Understanding the cellular mechanisms leading to CRPC is needed for development of novel treatments. We used long-term cell cultures to model CRPC; a testosterone-dependent cell line (VCaP-T) and cell line adapted to grow in low testosterone (VCaP-CT). These were used to uncover persistent and adaptive responses to testosterone level. RNA was sequenced to study AR-regulated genes. Expression level changed due to testosterone depletion in 418 genes in VCaP-T (AR-associated genes). To evaluate significance for CRPC growth, we compared which of them were adaptive i.e., restored expression level in VCaP-CT. Adaptive genes were enriched to steroid metabolism, immune response and lipid metabolism. The Cancer Genome Atlas Prostate Adenocarcinoma data were used to assess the association with cancer aggressiveness and progression-free survival. Expressions of 47 AR-associated or association gaining genes were statistically significant markers for progression-free survival. These included genes related to immune response, adhesion and transport. Taken together, we identified and clinically validated multiple genes being linked with progression of prostate cancer and propose several novel risk genes. Possible use as biomarkers or therapeutic targets should be studied further. + Copyright: © 2023 Nätkin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Nätkin + Reetta + R + https://orcid.org/0000-0001-7361-2057 + + Faculty of Medicine and Health Technology, Prostate Cancer Research Center, Tampere University and Tays Cancer Center, Tampere, Finland. + + + + Pennanen + Pasi + P + + Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, Tampere University Hospital, Tampere, Finland. + + + + Syvälä + Heimo + H + + Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, Tampere University Hospital, Tampere, Finland. + + + + Bläuer + Merja + M + + Tampere University Hospital and Faculty of Medicine and Health Technology, Tampere Pancreas Laboratory and Department of Gastroenterology and Alimentary Tract Surgery, Tampere University, Tampere, Finland. + + + + Kesseli + Juha + J + + Faculty of Medicine and Health Technology, Prostate Cancer Research Center, Tampere University and Tays Cancer Center, Tampere, Finland. + + + + Tammela + Teuvo L J + TLJ + + Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. + + + Department of Urology, Tays Cancer Center, Tampere, Finland. + + + + Nykter + Matti + M + + Faculty of Medicine and Health Technology, Prostate Cancer Research Center, Tampere University and Tays Cancer Center, Tampere, Finland. + + + + Murtola + Teemu J + TJ + + Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. + + + Department of Urology, Tays Cancer Center, Tampere, Finland. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + I have read the journal’s policy and the authors of this manuscript have the following competing interests: Teemu J. Murtola has received lecture fees from Novartis, Janssen, Ferring, Sanofi and Bayer, and is a paid consultant for Novartis, Sanofi and Janssen. Teuvo L. J. Tammela is a paid consultant for Astellas, GSK, Pfizer, Orion Pharma and Amgen. The remaining authors declare no competing interests. +
+ + + + 2022 + 06 + 07 + + + 2023 + 01 + 30 + + + 2023 + 2 + 22 + 13 + 52 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809527 + 10.1371/journal.pone.0281645 + PONE-D-22-16450 + + +
+ + + 36809532 + + 2023 + 02 + 22 + +
+ + 1932-6203 + + 18 + 2 + + 2023 + + + PloS one + PLoS One + + Prevalence of staphylococcal toxin in food contaminated by Staphylococcus spp.: Protocol for a systematic review with meta-analysis. + + e0282111 + + 10.1371/journal.pone.0282111 + + Food contamination by Staphylococcus spp. enterotoxigenic strains is quite common and despite underreporting caused by the short duration of clinical symptoms and lack of medical care, staphylococcal food poisoning is one of the most common Foodborne Diseases (FBD) in the world. This study describes a systematic review protocol with meta-analysis on the prevalence and types of staphylococcal enterotoxins in food, and the profile of contaminated foods. + The research will be conducted through the selection of studies reporting the analysis of staphylococcal enterotoxins in food contaminated by Staphylococcus spp. Searches will happen on the following databases: Medline (OVID), GALE, Science Direct, CAB Direct (CABI), Google Scholar, in addition to manual search in the list of references of articles, directory of theses and dissertations, and countries' health agencies. Reports will be imported into the application Rayyan. Two researchers will independently select studies and extract data, and a third reviewer will solve conflicting decisions. The primary outcome will be the identification of staphylococcal enterotoxins in food, and the secondary outcomes will include staphylococcal enterotoxin types and foods involved. To assess the risk of bias in the studies, the tool developed by the Joanna Briggs Institute (JBI) will be used. For data synthesis, a meta-analysis will be performed. However, in case that is not possible, a narrative synthesis of the most relevant results will be carried out. + This protocol will serve as the basis for a systematic review that aims to relate the results of existing studies on the staphylococcal enterotoxin prevalence and types in food, and the profile of the contaminated foods. The results will broaden the perception of food safety risks, highlight existing literature gaps, contribute to the study of the epidemiological profile and may guide the allocation of health resources for the development of preventive measures related. + PROSPERO registration number: CRD42021258223. + Copyright: © 2023 Freitas et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Freitas + Juliana Karla Garcia Ribeiro + JKGR + + Nutrition Postgraduate Program, Health Sciences Center, Federal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil. + + + + Assis + Cristiane Fernandes de + CF + + Nutrition Postgraduate Program, Health Sciences Center, Federal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil. + + + Department of Pharmacy, Health Sciences Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil. + + + + Oliveira + Thailla Raquel Moura de + TRM + + Department of Nutrition, Health Sciences Center, Federal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil. + + + + Maia + Cláudio Márcio de Medeiros + CMM + + Nutrition Postgraduate Program, Health Sciences Center, Federal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil. + + + + de Sousa + Bruno Jonatan + BJ + https://orcid.org/0000-0001-5367-236X + + Nutrition Postgraduate Program, Health Sciences Center, Federal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil. + + + + Medeiros + Gidyenne Christiane Bandeira Silva de + GCBS + + Department of Nutrition, Health Sciences Center, Federal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil. + + + Systematic Review and Meta-Analysis Laboratory (Lab-SYS) CNPq-UFRN, Natal, RN, Brazil. + + + + Seabra + Larissa Mont'Alverne Jucá + LMJ + + Nutrition Postgraduate Program, Health Sciences Center, Federal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil. + + + Department of Nutrition, Health Sciences Center, Federal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil. + + + + Chaves Damasceno + Karla Suzanne Florentino da Silva + KSFDS + https://orcid.org/0000-0001-6884-1023 + + Nutrition Postgraduate Program, Health Sciences Center, Federal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil. + + + Department of Nutrition, Health Sciences Center, Federal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 09 + 14 + + + 2023 + 02 + 01 + + + 2023 + 2 + 22 + 13 + 52 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809532 + 10.1371/journal.pone.0282111 + PONE-D-22-25597 + + +
+ + + 36809529 + + 2023 + 02 + 22 + +
+ + 1932-6203 + + 18 + 2 + + 2023 + + + PloS one + PLoS One + + Effect of photodynamic therapy on choroid of the medial area from optic disc in patients with central serous chorioretinopathy. + + e0282057 + + 10.1371/journal.pone.0282057 + + To explore the effect of photodynamic therapy (PDT) on the choroid of medial area from optic disc and factors correlated with treatment outcomes, we evaluated choroidal changes using ultra-widefield optical coherence tomography (UWF-OCT) after PDT for central serous chorioretinopathy (CSC). + In this retrospective case-series, we included CSC patients who received a standard-dose of full-fluence PDT. UWF-OCT were examined at baseline and 3 months after treatment. We measured choroidal thickness (CT), classified into central, middle, and peripheral sectors. We examined CT changes after PDT by sectors and treatment outcome. + Twenty-two eyes of 21 patients (20 males; mean age 58.7 ± 12.3 years) were included. CT reduction after PDT was significant in all sectors, including peripheral areas: supratemporal, 330.5 ± 90.6 μm vs. 237.0 ± 53.2 μm; infratemporal, 240.0 ± 89.4 μm vs. 209.9 ± 55.1 μm; supranasal, 237.7 ± 59.8 vs 209.3 ± 69.3 μm; infranasal, 172.6 ± 47.2 μm vs. 155.1 ± 38.2 μm (P < 0.001, for all). In patients with retinal fluid resolution, despite no apparent difference in baseline CT, there was more significant reduction after PDT in supratemporal and supranasal peripheral sectors, compared with patients without resolution: supratemporal, 41.9 ± 30.3 μm vs. -1.6 ± 22.7 μm; supranasal, 24.7 ± 15.3 μm vs. 8.5 ± 3.6 μm (P < 0.019, for both). + Whole CT decreased after PDT, including in medial areas from optic disc. This may be associated with the treatment response of PDT for CSC. + Copyright: © 2023 Funatsu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Funatsu + Ryoh + R + + Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. + + + + Sonoda + Shozo + S + + Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. + + + + Terasaki + Hiroto + H + https://orcid.org/0000-0003-4085-138X + + Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. + + + + Shiihara + Hideki + H + + Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. + + + + Mihara + Naohisa + N + + Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. + + + + Horie + Juun + J + + Canon Inc., Tokyo, Japan. + + + + Sakamoto + Taiji + T + + Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 09 + 08 + + + 2023 + 02 + 06 + + + 2023 + 2 + 22 + 13 + 52 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809529 + 10.1371/journal.pone.0282057 + PONE-D-22-24973 + + +
+ + + 36809531 + + 2023 + 02 + 22 + +
+ + 1932-6203 + + 18 + 2 + + 2023 + + + PloS one + PLoS One + + pXOOY: A dual-function vector for expression of membrane proteins in Saccharomyces cerevisiae and Xenopus laevis oocytes. + + e0281868 + + 10.1371/journal.pone.0281868 + + On the quest for solving structures of membrane proteins by X-ray crystallography or cryo-EM, large quantities of ultra-pure protein are a paramount prerequisite. Obtaining enough protein of such high standard is not a trivial task, especially for difficult-to-express membrane proteins. Producing membrane protein for structural studies is often performed in Escherichia coli or Saccharomyces cerevisiae and is frequently complemented with functional studies. Ion channels and electrogenic receptors are traditionally studied in terms of their electrophysiological behavior, which cannot be performed in neither E. coli nor yeast. Therefore, they are frequently characterized in mammalian cells or in Xenopus laevis oocytes. To avoid generating two different plasmids, we here describe the construction of a dual-function plasmid, pXOOY, for membrane protein production in yeast and for electrophysiology in oocytes. pXOOY was constructed such that all elements required for oocyte expression were copied from the dual Xenopus-mammalian vector pXOOM and meticulously introduced into the high-yield yeast expression vector pEMBLyex4. pXOOY is thus designed to preserve the high yield of protein from pEMBLyex4 while simultaneously permitting in vitro transcription for expression in oocytes. We evaluated the performance of pXOOY by comparing expression of two yeast codon optimized human potassium channels, ohERG and ohSlick (Slo2.1) from pXOOY to expression of these channels obtained from the reference vectors pEMBLyex4 and pXOOM. Our proof-of-concept study indicates that accumulation in PAP1500 yeast cells was higher when the channels were expressed from pXOOY, which was verified both qualitatively and quantitatively. Two-electrode voltage clamp measurements in oocytes showed that the pXOOY constructs encoding ohERG and ohSlick gave currents with full preservation of electrophysiological characteristics. Our results show that it is possible to design a dual-function Xenopus-yeast vector without compromising expression in yeast and simultaneously maintaining channel activity in oocytes. + Copyright: © 2023 Vold et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Vold + Victoria Amstrup + VA + https://orcid.org/0000-0003-0139-9976 + + Department of Biology, University of Copenhagen, Copenhagen Ø, Denmark. + + + Department of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark. + + + + Glanville + Sebastian + S + + Department of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark. + + + + Klaerke + Dan Arne + DA + + Department of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark. + + + + Pedersen + Per Amstrup + PA + https://orcid.org/0000-0001-8648-9748 + + Department of Biology, University of Copenhagen, Copenhagen Ø, Denmark. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 11 + 17 + + + 2023 + 02 + 02 + + + 2023 + 2 + 22 + 13 + 52 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809531 + 10.1371/journal.pone.0281868 + PONE-D-22-31694 + + +
+ + + 36809530 + + 2023 + 02 + 22 + +
+ + 1932-6203 + + 18 + 2 + + 2023 + + + PloS one + PLoS One + + Investigating speed-safety association: Considering the unobserved heterogeneity and human factors mediation effects. + + e0281951 + + 10.1371/journal.pone.0281951 + + The relationship between mean speed and crash likelihood is unclear in the literature. The contradictory findings can be attributed to the masking effects of the confounding variables in this association. Moreover, the unobserved heterogeneity has almost been criticized as a reason behind the current inconclusive results. This research provides an effort to develop a model that analyzes the mean speed-crash frequency relationship by crash severity and type. Also, the confounding and mediation effects of the environment, driver, and traffic-related attributes have been considered. To this end, the loop detector and crash data were aggregated daily for rural multilane highways of Tehran province, Iran, covering two years, 2020-2021. The partial least squares path modeling (PLS-PM) was employed for crash causal analysis along with the finite mixture partial least squares (FIMIX-PLS) segmentation to account for potential unobserved heterogeneity between observations. The mean speed was negatively and positively associated with the frequency of property damage-only (PDO) and severe accidents, respectively. Moreover, driver-related variables, including tailgating, distracted driving, and speeding, played key mediation roles in associating traffic and environmental factors with the crash risk. The higher the mean speed and the lower the traffic volume, the higher odds of distracted driving. Distracted driving was, in turn, associated with the higher vulnerable road users (VRU) accidents and single-vehicle accidents, triggering a higher frequency of severe accidents. Moreover, lower mean speed and higher traffic volume were positively correlated with the percentage of tailgating violations, which, in turn, predicted multi-vehicle accidents as the main predictor of PDO crash frequency. In conclusion, the mean speed effects on the crash risk are entirely different for each crash type through distinct crash mechanisms. Hence, the distinct distribution of crash types in different datasets might have led to current inconsistent results in the literature. + Copyright: © 2023 Nassiri, Mohammadpour. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Nassiri + Habibollah + H + https://orcid.org/0000-0003-1102-0296 + + Civil Engineering Department, Sharif University of Technology, Tehran, Iran. + + + + Mohammadpour + Seyed Iman + SI + https://orcid.org/0000-0002-6878-6818 + + Civil Engineering Department, Sharif University of Technology, Tehran, Iran. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 12 + 20 + + + 2023 + 02 + 04 + + + 2023 + 2 + 22 + 13 + 52 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809530 + 10.1371/journal.pone.0281951 + PONE-D-22-34806 + + +
+ + + 36809528 + + 2023 + 02 + 22 + +
+ + 1932-6203 + + 18 + 2 + + 2023 + + + PloS one + PLoS One + + Health outcomes and healthcare resource utilization among Veterans with stage IV non-small cell lung cancer treated with second-line chemotherapy versus immunotherapy. + + e0282020 + + 10.1371/journal.pone.0282020 + + Until recently, multi-agent chemotherapy (CT) was the standard of care for patients with advanced non-small cell lung cancer (NSCLC). Clinical trials have confirmed benefits in overall survival (OS) and progression-free survival with immunotherapy (IO) compared to CT. This study compares real-world treatment patterns and outcomes between CT and IO administrations in second-line (2L) settings for patients with stage IV NSCLC. + This retrospective study included patients in the United States Department of Veterans Affairs healthcare system diagnosed with stage IV NSCLC during 2012-2017 and receiving IO or CT in the 2L. Patient demographics and clinical characteristics, healthcare resource utilization (HCRU), and adverse events (AEs) were compared between treatment groups. Logistic regression was used to examine differences in baseline characteristics between groups, and inverse probability weighting multivariable Cox proportional hazard regression was used to analyze OS. + Among 4,609 Veterans who received first-line (1L) therapy for stage IV NSCLC, 96% received 1L CT alone. A total of 1,630 (35%) were administered 2L systemic therapy, with 695 (43%) receiving IO and 935 (57%) receiving CT. Median age was 67 years (IO group) and 65 years (CT group); most patients were male (97%) and white (76-77%). Patients administered 2L IO had a higher Charlson Comorbidity Index than those administered CT (p = 0.0002). 2L IO was associated with significantly longer OS compared with CT (hazard ratio 0.84, 95% CI 0.75-0.94). IO was more frequently prescribed during the study period (p < 0.0001). No difference in rate of hospitalizations was observed between the two groups. + Overall, the proportion of advanced NSCLC patients receiving 2L systemic therapy is low. Among patients treated with 1L CT and without IO contraindications, 2L IO should be considered, as this supports potential benefit of IO for advanced NSCLC. The increasing availability and indications for IO will likely increase the administration of 2L therapy to NSCLC patients. + Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. + + + + Williams + Christina D + CD + https://orcid.org/0000-0002-6925-3482 + + Cooperative Studies Program Epidemiology Center-Durham, Durham Veterans Affairs Health Care System, Durham, North Carolina, United States of America. + + + Medical Oncology, Department of Medicine, Duke University, Durham, North Carolina, United States of America. + + + + Allo + Mina A + MA + + Bristol-Myers Squibb Company, US Health Economics and Outcomes Research, Princeton, New Jersey, United States of America. + + + + Gu + Lin + L + + Cooperative Studies Program Epidemiology Center-Durham, Durham Veterans Affairs Health Care System, Durham, North Carolina, United States of America. + + + Duke Cancer Institute, Biostatistics Shared Resource, Duke University, Durham, North Carolina, United States of America. + + + + Vashistha + Vishal + V + https://orcid.org/0000-0003-4359-6636 + + Hematologic Malignancies and Cellular Therapy, Department of Medicine, Duke University, Durham, North Carolina, United States of America. + + + Division of Hematology-Oncology, Medical Service, Durham Veterans Affairs Health Care System, Durham, North Carolina, United States of America. + + + + Press + Ashlyn + A + + Cooperative Studies Program Epidemiology Center-Durham, Durham Veterans Affairs Health Care System, Durham, North Carolina, United States of America. + + + + Kelley + Michael + M + + Medical Oncology, Department of Medicine, Duke University, Durham, North Carolina, United States of America. + + + Division of Hematology-Oncology, Medical Service, Durham Veterans Affairs Health Care System, Durham, North Carolina, United States of America. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + This study was supported by Bristol-Myers Squibb Company (BMS). Dr. Allo was affiliated with BMS. BMS did not have access to underlying data and did not contribute to any data analysis. This commercial affiliation does not alter the adherence to PLOS ONE policies on sharing data and materials. The authors declare no other competing interests. +
+ + + + 2022 + 03 + 07 + + + 2023 + 02 + 06 + + + 2023 + 2 + 22 + 13 + 52 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809528 + 10.1371/journal.pone.0282020 + PONE-D-22-02351 + + +
+ + + 36809534 + + 2023 + 02 + 22 + +
+ + 1463-9084 + + + 2023 + Feb + 21 + + + Physical chemistry chemical physics : PCCP + Phys Chem Chem Phys + + Fabrication of fullerene-supported La2O3-C60 nanocomposites: dual-functional materials for photocatalysis and supercapacitor electrodes. + 10.1039/d2cp05357h + + Nowadays, water pollution and energy crises worldwide force researchers to develop multi-functional and highly efficient nanomaterials. In this scenario, the present work reports a dual-functional La2O3-C60 nanocomposite fabricated by a simple solution method. The grown nanomaterial worked as an efficient photocatalyst and proficient electrode material for supercapacitors. The physical and electrochemical properties were studied by state-of-the-art techniques. XRD, Raman spectroscopy, and FTIR spectroscopy confirmed the formation of the La2O3-C60 nanocomposite with TEM nano-graphs, and EDX mapping exhibits the loading of C60 on La2O3 particles. XPS confirmed the presence of varying oxidation states of La3+/La2+. The electrochemical capacitive properties were tested by CV, EIS, GCD, ECSA, and LSV, which indicated that the La2O3-C60 nanocomposite can be effectively used as an electrode material for durable and efficient supercapacitors. The photocatalytic test using methylene blue (MB) dye revealed the complete photodegradation of the MB dye under UV light irradiation after 30 min by a La2O3-C60 catalyst with a reusability up to 7 cycles. The lower energy bandgap, presence of deep-level emissions, and lower recombination rate of photoinduced charge carriers in the La2O3-C60 nanocomposite than those of bare La2O3 are responsible for enhanced photocatalytic activity with low-power UV irradiation. The fabrication of multi-functional and highly efficient electrode materials and photocatalysts such as La2O3-C60 nanocomposites is beneficial for the energy industry and environmental remediation applications. + + + + Munawar + Tauseef + T + + Institute of Physics, The Islamia University of Bahawalpur, 63100, Pakistan. faisal.iqbal@iub.edu.pk. + + + + Sardar + Sonia + S + + Institute of Physics, The Islamia University of Bahawalpur, 63100, Pakistan. faisal.iqbal@iub.edu.pk. + + + + Mukhtar + Faisal + F + + Institute of Physics, The Islamia University of Bahawalpur, 63100, Pakistan. faisal.iqbal@iub.edu.pk. + + + + Nadeem + Muhammad Shahid + MS + + Institute of Physics, The Islamia University of Bahawalpur, 63100, Pakistan. faisal.iqbal@iub.edu.pk. + + + + Manzoor + Sumaira + S + + Institute of Chemical Sciences, Bahauddin Zakariya University, Multan 60800, Pakistan. + + + + Ashiq + Muhammad Naeem + MN + http://orcid.org/0000-0001-8561-3065 + + Institute of Chemical Sciences, Bahauddin Zakariya University, Multan 60800, Pakistan. + + + + Khan + Shoukat Alim + SA + + Division of Sustainable Development, College of Science and Engineering, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar. + + + + Koc + Muammer + M + + Division of Sustainable Development, College of Science and Engineering, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar. + + + + Iqbal + Faisal + F + http://orcid.org/0000-0001-6411-1226 + + Institute of Physics, The Islamia University of Bahawalpur, 63100, Pakistan. faisal.iqbal@iub.edu.pk. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Phys Chem Chem Phys + 100888160 + 1463-9076 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 53 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809534 + 10.1039/d2cp05357h + + +
+ + + 36809533 + + 2023 + 02 + 22 + +
+ + 2042-7670 + + + 2023 + Feb + 21 + + + The Veterinary record + Vet Rec + + Antimicrobial resistance of endometrial bacterial isolates collected from UK Thoroughbred mares between 2014 and 2020. + + e2591 + + 10.1002/vetr.2591 + + Antimicrobial resistance (AMR) is important in equine reproduction, as antimicrobials have historically been widely used in the management of breeding mares. However, evidence of the characteristics of AMR in uterine isolates is limited in the UK. The objective of this retrospective study was therefore to describe temporal changes in AMR patterns of bacteria isolated from the endometrium of Thoroughbred broodmares in south-east England between 2014 and 2020. + Endometrial swabs were processed for microbiology and antimicrobial susceptibility testing (AST). For frequently isolated bacteria, changes in AMR patterns over time were assessed using a logistic regression model. + From 18,996 endometrial swabs, 30.5% were positive for microbial culture. AST was performed on 2091 isolates, representing 1924 swabs collected from 1370 mares located at 132 premises. Beta-haemolytic Streptococcus (BHS, 52.5%) and Escherichia coli (25.8%) were most frequently isolated. In BHS, resistance to enrofloxacin (p = 0.02), nitrofurazone (p < 0.001) and oxytetracycline (p < 0.01) increased significantly between 2014 and 2020, while resistance to trimethoprim-sulfamethoxazole (p < 0.001) decreased. In E. coli, resistance to nitrofurazone increased (p = 0.04) and resistance to gentamycin (p = 0.02) and trimethoprim-sulfamethoxazole (p < 0.001) decreased. + Variations in the specimen collection protocols might have affected the frequency of isolates detected. + Between 2014 and 2020, AMR changed in this bacterial population. However, there was no significant increase in resistance to penicillin (99.6% BHS susceptible), gentamycin (81.7% E. coli susceptible) or ceftiofur. + © 2023 British Veterinary Association. + + + + Rathbone + Polly + P + + Department of Comparative Biomedical Sciences, Royal Veterinary College, Hatfield, UK. + + + + Arango-Sabogal + Juan C + JC + https://orcid.org/0000-0003-3395-8410 + + Department of Pathobiology and Population Sciences, Royal Veterinary College, Hatfield, UK. + + + Département de Pathologie et Microbiologie, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, Quebec, Canada. + + + + De Mestre + Amanda M + AM + + Department of Comparative Biomedical Sciences, Royal Veterinary College, Hatfield, UK. + + + + Scott + Camilla J + CJ + + Rossdales Veterinary Surgeons, Newmarket, UK. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Vet Rec + 0031164 + 0042-4900 + + IM + + antimicrobials + equine reproduction + resistance + +
+ + + + 2022 + 12 + 13 + + + 2022 + 01 + 10 + + + 2022 + 12 + 30 + + + 2023 + 2 + 22 + 13 + 52 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809533 + 10.1002/vetr.2591 + + + REFERENCES + + Karaiskos I, Giamarellou H. Carbapenem-sparing strategies for ESBL producers: when and how. Antibiotics. 2020;9(2):61. + + + Maddox TW, Clegg PD, Williams NJ, Pinchbeck GL. Antimicrobial resistance in bacteria from horses: epidemiology of antimicrobial resistance. Equine Vet J. 2015;47(6):756-65 + + + McEwan S, Collignon P. Antimicrobial resistance: a One Health perspective. Microbiol Spectr. 2018;6(2). + + + Causey RC. Making sense of equine uterine infections: the many faces of physical clearance. Vet J. 2006;172(3):405-21. + + + Williamson DA, Carter GP, Howden BP. Current and emerging topical antibacterials and antiseptics: agents, action, and resistance patterns. Clin Microbiol Rev. 2017;30:827-60. + + + Ranucci E, Romagnoli P, Giaccone V. Antimicrobial resistance: a global emerging threat to public health systems. Food Sci Nutr. 2017;57(13):2857-76. + + + Haddad N, Kanj SS, Awad LS, Abdallah DI, Moghnieh RA. The 2018 Lebanese Society of Infectious Diseases and Clinical Microbiology Guidelines for the use of antimicrobial therapy in complicated intra-abdominal infections in the era of antimicrobial resistance. BMC Infect Dis. 2019;19(1):293. + + + Johns I, Adams E. Trends in antimicrobial resistance in equine bacterial isolates: 1999-2012. Vet Rec. 2015;176(13):334. + + + Mitchell AR, Diel de Amorim M, Thachil AJ, Altier C, Cheong SH. Uterine bacterial isolates from mares and their resistance to antimicrobials. J Equine Vet Sci. 2018;66:114. + + + Albihn A, Båverud V, Magnusson U. Uterine microbiology and antimicrobial susceptibility in isolated bacteria from mares with fertility problems. Acta Vet Scand. 2003;44(3-4):121-9. + + + Pisello L, Rampacci E, Stefanetti V, Beccati F, Hyatt DR, Coletti M, et al. Temporal efficacy of antimicrobials against aerobic bacteria isolated from equine endometritis: an Italian retrospective analysis (2010-2017). Vet Rec. 2019;185(19):598. + + + Davis HA, Stanton MB, Thungrat K, Boothe DM. Uterine bacterial isolates from mares and their resistance to antimicrobials: 8,296 cases (2003-2008). J Am Vet Med Assoc. 2013;242(7):977-83. + + + Frontoso R, De Carlo E, Pasolini MP, van der Meulen K, Pagnini U, Iovane G, et al. Retrospective study of bacterial isolates and their antimicrobial susceptibilities in equine uteri during fertility problems. Res Vet Sci. 2008;84(1):1-6. + + + Rose BV, Firth M, Morris B, Roach JM, Wathes DC, Verheyen KLP, et al. Descriptive study of current therapeutic practices, clinical reproductive findings and incidence of pregnancy loss in intensively managed thoroughbred mares. Anim Reprod Sci. 2018;188:74-84. + + + Mouncey R, Arango-Sabogal J, de Mestre AM, Verheyen KLP. Descriptive study of medication usage and occurrence of disease and injury during gestation in Thoroughbred broodmares. J Equine Vet Sci. 2022;118:104104. + + + Allen WR, Brown L, Wright M, Wilsher S. Reproductive efficiency of Flatrace and National Hunt Thoroughbred mares and stallions in England. Equine Vet J. 2007;39(5):438-45. + + + Morris LHA, Allen WR. Reproductive efficiency of intensively managed Thoroughbred mares in Newmarket. Equine Vet J. 2002;34:51-60. + + + Parveen S, Lukasik J, Scott TM, Tamplin ML, Portier KM, Sheperd S, et al. Geographical variation in antibiotic resistance profiles of Escherichia coli isolated from swine, poultry, beef and dairy cattle farm water retention ponds in Florida. J Appl Microbiol. 2006;100(1):50-7. + + + Munson E, Hueppchen E, Zeman H. Surveillance of Wisconsin organisms for trends in antimicrobial resistance and epidemiology: introduction to the program and summary of 2016 geographic variation. Wis Med J. 2018;117(3):116-21. + + + Woolhouse M, Ward M, Van Bunnik B, Farrar J. Antimicrobial resistance in humans, livestock and the wider environment. Philos Trans R Soc Biol Sci. 2015;370(1670):20140083. + + + Riddle WT, LeBlanc MM, Stromberg AJ. Relationships between uterine culture, cytology and pregnancy rates in a Thoroughbred practice. Theriogenology. 2007;68(3):395-402. + + + Erol E, Locke SJ, Donahoe JK, Mackin MA, Carter CN. Beta-hemolytic Streptococcus spp. from horses: a retrospective study (2000-2010). J Vet Diagn Invest. 2012;24(1):142-7. + + + British Veterinary Association. BVA policy position on the responsible use of antimicrobials in food producing animals. 2019; 1-9. Accessed 12/08/2021. Available from: https://www.bva.co.uk/media/1161/bva-policy-position-on-the-responsible-use-of-antimicrobials-in-food-producing-animals-1.pdf + + + Scofield D, Black J, Wittenburg L, Gustafson D, Ferris R, Hatzel J, et al. Endometrial tissue and blood plasma concentration of ceftiofur and metabolites following intramuscular administration of ceftiofur crystalline free acid to mares. Equine Vet J. 2014;46(5):606-10. + + + Witte TS, Bergwerff AA, Scherpenisse P, Drillich M, Heuwieser W. Ceftiofur derivates in serum and endometrial tissue after intramuscular administration in healthy mares. Theriogenology. 2010;74(3):466-72. + + + Fumuso E, Checura C, Lossino L, Soto P, Sánchez S. Endometrial tissue concentrations of enrofloxacin after intrauterine administration to mares. Vet Res Commun. 2002;26(5):371-80. + + + Bourély C, Cazeau G, Jarrige N, Haenni M, Gay E, Leblond A. Antimicrobial resistance in bacteria isolated from diseased horses in France. Equine Vet J. 2020;52(1):112-9. + + + Scott C, Dujovne G, Christensen B. Endometrial tissue concentrations of ceftiofur derivatives following intrauterine infusion in both non-infected mares and mares with experimentally induced endometritis. Clin Theriogenol. 2016;8(2):113-9. + + + Johns I, Verheyen K, Good L, Rycroft A. Antimicrobial resistance in faecal Escherichia coli isolates from horses treated with antimicrobials: a longitudinal study in hospitalised and non-hospitalised horses. Vet Microbiol. 2012;159(3-4):381-9. + + + Isgren CM, Williams NJ, Fletcher OD, Timofte D, Newton RJ, Maddox TW, et al. Antimicrobial resistance in clinical bacterial isolates from horses in the UK. Equine Vet J. 2022;54(2):390-414. + + + McCalla DR, Kaiser C, Green MHL. Genetics of nitrofurazone resistance in Escherichia coli. J Bacteriol. 1978;133(1):10-6. + + + Magiorakos AP, Srinivasan A, Carey RB, Carmeli Y, Falagas ME, Giske CG, et al. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect. 2012;18(3):268-81. + + + Falagas ME, Koletsi PK, Bliziotis IA. The diversity of definitions of multidrug-resistant (MDR) and pandrug-resistant (PDR) Acinetobacter baumannii and Pseudomonas aeruginosa. J Med Microbiol. 2006;55:1619-29. + + + Delcour AH. Outer membrane permeability and antibiotic resistance. Biochim Biophys Acta. 2009;1794:808-16. + + + Poole K, Srikumar R. Multidrug efflux in Pseudomonas aeruginosa: components, mechanisms and clinical significance. Curr Top Med Chem. 2001;1:59-71. + + + Allen JL, Begg AP, Browning GF. Outbreak of equine endometritis caused by a genotypically identical strain of Pseudomonas aeruginosa. J Vet Diagnostic Investig. 2011;6(23):1236-9. + + + Shin SJ, Lein DH, Aronson AL, Nusbaum SR. The bacteriological culture of equine uterine contents, in-vitro sensitivity of organisms isolated and interpretation. J Reprod Fertil. 1979;27:307-15. + + + Ricketts SW, Young AME. Uterine and clitorial cultures. In: Equine reproduction; Mckinnon A, Voss JL. Wiley-Blackwell; 1993. p. 234-45. + + + Schöniger S, Schoon H-A. The healthy and diseased equine endometrium: a review of morphological features and molecular analyses. Animals. 2020;10(4):625. + + + Nielsen JM. Endometritis in the mare: a diagnostic study comparing cultures from swab and biopsy. Theriogenology. 2005;64:510-8. + + + Petersen MR, Skive B, Christoffersen M, Lu K, Nielsen JM, Troedsson MHT, et al. Activation of persistent Streptococcus equi subspecies zooepidemicus in mares with subclinical endometritis. Vet Microbiol. 2015;179(1-2):119-25. + + + Pycock JF, Newcombe JR. Assessment of the effect of three treatments to remove intrauterine fluid on pregnancy rate in the mare. Vet Rec. 1996;138(14):320-3. + + + VMD. Responsible antibiotic use under the prescribing cascade [Internet]. 2014 [cited 2022 May 19]. Available from: https://www.gov.uk/guidance/responsible-antibiotic-use-under-the-prescribing-cascade + + + McKinnon AO, Squires EL, Vaala WE, Varner DD. Fungal endometritis. In: Equine reproduction. 2nd Editioin; Wiley-Blackwell; 2011. p. 2643-51. + + + Adams R, Smith J, Locke S, Phillips E, Erol E, Carter C, et al. An epidemiologic study of antimicrobial resistance of Staphylococcus species isolated from equine samples submitted to a diagnostic laboratory. BMC Vet Res. 2018;14(1):42. + + + McKellar QA, Sanchez Bruni SF, Jones DG. Pharmacokinetic/pharmacodynamic relationships of antimicrobial drugs used in veterinary medicine. J Vet Pharmacol Ther. 2004;27(6):503-14. + + + Leblanc MM. The chronically infertile mare. American Association of Equine Practitioners; 2008. + + + +
+ + + 36809535 + + 2023 + 02 + 22 + +
+ + 1463-9084 + + + 2023 + Feb + 21 + + + Physical chemistry chemical physics : PCCP + Phys Chem Chem Phys + + First principles approach for promising oxide ion conducting ABGa3O7 melilite structures. + 10.1039/d2cp05978a + + Melilite type structures of the general composition A3+1+xB2+1-xGa3O7+x/2 provide high oxide ion conductivity for x > 0 due to the presence of mobile oxide interstitials. While the structure can accommodate a variety of A- and B-cations, compositions besides La3+/Sr2+ are rarely investigated and the literature is inconclusive. In this contribution, combinations of A-cations (Ce, La, Nd, Pr, Sm) and B-cations (Mg, Ca, Sr, Ba) are investigated by density functional theory calculations. Two criteria for high ionic conductivity are examined: The variation of the site energies for different configurations and the average migration barriers. Promising combinations of cations are suggested for further investigation. + + + + Neitzel-Grieshammer + Steffen + S + http://orcid.org/0000-0001-7583-6417 + + Institute of Physical Chemistry, RWTH Aachen University, Landoltweg 2, Aachen 52074, Germany. steffen.grieshammer@rwth-aachen.de. + + + JARA-HPC, RWTH Aachen University and Forschungszentrum Jülich GmbH, Aachen 52056, Germany. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Phys Chem Chem Phys + 100888160 + 1463-9076 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 53 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809535 + 10.1039/d2cp05978a + + +
+ + + 36809540 + + 2023 + 02 + 22 + +
+ + 2051-6355 + + + 2023 + Feb + 21 + + + Materials horizons + Mater Horiz + + Eco-friendly inorganic molecular novel antiperovskites for light-emitting application. + 10.1039/d2mh01216b + + The development of perovskite light-emitting diodes (PeLEDs) has progressed rapidly over the past several years, with high external quantum efficiencies exceeding 20%. However, the deployment of PeLEDs in commercial devices still faces severe challenges, such as environmental pollution, instability and low photoluminescence quantum yields (PLQYs). In this work, we perform high-throughput calculations to exhaustively search the unexplored and eco-friendly novel antiperovskite space (formula: X3B[MN4], with octahedron [BX6] and tetrahedron [MN4]). The novel antiperovskites have a unique structure whereby a tetrahedron can be embedded into an octahedral skeleton as a light-emitting center causing a space confinement effect, leading to the characteristics of a low-dimensional electronic structure, which then makes these materials potential light-emitting material candidates with a high PLQY and light-emitting stability. Under the guidance of newly derived tolerance, octahedral, and tetrahedral factors, 266 stable candidates are successfully screened out from 6320 compounds. Moreover, the antiperovskite materials Ba3I0.5F0.5(SbS4), Ca3O(SnO4), Ba3F0.5I0.5(InSe4), Ba3O0.5S0.5(ZrS4), Ca3O(TiO4), and Rb3Cl0.5I0.5(ZnI4) possess an appropriate bandgap, thermodynamic and kinetic stability, and excellent electronic and optical properties, making them promising light-emitting materials. + + + + Luo + Jiawei + J + http://orcid.org/0000-0001-6306-0965 + + School of Physics, Southeast University, Nanjing 211189, China. juming@seu.edu.cn. + + + + Ji + Qun + Q + + School of Physics, Southeast University, Nanjing 211189, China. juming@seu.edu.cn. + + + + Wu + Yilei + Y + + School of Physics, Southeast University, Nanjing 211189, China. juming@seu.edu.cn. + + + + Gao + Xinying + X + + School of Physics, Southeast University, Nanjing 211189, China. juming@seu.edu.cn. + + + + Wang + Jinlan + J + http://orcid.org/0000-0002-4529-874X + + School of Physics, Southeast University, Nanjing 211189, China. juming@seu.edu.cn. + + + + Ju + Ming-Gang + MG + http://orcid.org/0000-0003-4285-7937 + + School of Physics, Southeast University, Nanjing 211189, China. juming@seu.edu.cn. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Mater Horiz + 101623537 + 2051-6347 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 53 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809540 + 10.1039/d2mh01216b + + +
+ + + 36809537 + + 2023 + 02 + 22 + +
+ + 1477-0539 + + + 2023 + Feb + 21 + + + Organic & biomolecular chemistry + Org Biomol Chem + + Rhodium(III)-catalyzed C-H alkylation of arylhydrophthalazinediones with α-Cl ketones as sp3-carbon alkylated agents. + 10.1039/d3ob00091e + + A Rh(III)-catalyzed C-H bond direct alkylation between 2-arylphthalazine-1,4-diones and α-Cl ketones, which are sp3-carbon synthons, under mild conditions has been disclosed. The corresponding phthalazine derivatives are readily obtained in moderate to excellent yields with a wide range of substrates and high functional group tolerance. The practicality and utility of this method are demonstrated by the derivatization of the product. + + + + Li + He + H + http://orcid.org/0000-0003-3588-0215 + + Innovation Team of Optical Functional Molecular Devices, Inner Mongolia Key Laboratory for the Natural Products Chemistry and Functional Molecular Synthesis, College of Chemistry and Materials Science, Inner Mongolia Minzu University, Tongliao 028000, China. lihe0218@126.com. + + + + Gu + Haichun + H + + Innovation Team of Optical Functional Molecular Devices, Inner Mongolia Key Laboratory for the Natural Products Chemistry and Functional Molecular Synthesis, College of Chemistry and Materials Science, Inner Mongolia Minzu University, Tongliao 028000, China. lihe0218@126.com. + + + + Xu + Ning + N + + Innovation Team of Optical Functional Molecular Devices, Inner Mongolia Key Laboratory for the Natural Products Chemistry and Functional Molecular Synthesis, College of Chemistry and Materials Science, Inner Mongolia Minzu University, Tongliao 028000, China. lihe0218@126.com. + + + + Lu + Ye + Y + http://orcid.org/0000-0003-4995-5265 + + Inner Mongolia Key Laboratory of Carbon Nanomaterials, Nano Innovation Institute (NII), College of Chemistry and Materials Science, Inner Mongolia Minzu University, Tongliao 028000, China. + + + + Jin + Xinxin + X + + Innovation Team of Optical Functional Molecular Devices, Inner Mongolia Key Laboratory for the Natural Products Chemistry and Functional Molecular Synthesis, College of Chemistry and Materials Science, Inner Mongolia Minzu University, Tongliao 028000, China. lihe0218@126.com. + + + + Li + Jiaqi + J + + Innovation Team of Optical Functional Molecular Devices, Inner Mongolia Key Laboratory for the Natural Products Chemistry and Functional Molecular Synthesis, College of Chemistry and Materials Science, Inner Mongolia Minzu University, Tongliao 028000, China. lihe0218@126.com. + + + + Guo + Hongyu + H + + College of Chemistry and Chemical Engineering, Taiyuan University of Technology, Taiyuan, 030024, China. 619561895@qq.com. + + + + Cao + Dawei + D + http://orcid.org/0000-0003-0516-9844 + + Key Laboratory of Comprehensive and Highly Efficient Utilization of Salt Lake Resources, Qinghai Institute of Salt Lakes, Chinese Academy of Sciences, Xining, 810008, China. + + + + Liu + Jinglin + J + + Innovation Team of Optical Functional Molecular Devices, Inner Mongolia Key Laboratory for the Natural Products Chemistry and Functional Molecular Synthesis, College of Chemistry and Materials Science, Inner Mongolia Minzu University, Tongliao 028000, China. lihe0218@126.com. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Org Biomol Chem + 101154995 + 1477-0520 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 53 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809537 + 10.1039/d3ob00091e + + +
+ + + 36809542 + + 2023 + 02 + 22 + +
+ + 1537-6591 + + + 2023 + Feb + 21 + + + Clinical infectious diseases : an official publication of the Infectious Diseases Society of America + Clin Infect Dis + + COVID-19 Convalescent Plasma Reaches the Slope of Enlightenment in the Gartner Hype Cycle. + ciad092 + 10.1093/cid/ciad092 + + + Shoham + Shmuel + S + 0000-0001-7276-7786 + + Johns Hopkins University School of Medicine. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Clin Infect Dis + 9203213 + 1058-4838 + + IM +
+ + + + 2023 + 02 + 05 + + + 2023 + 02 + 10 + + + 2023 + 02 + 14 + + + 2023 + 2 + 22 + 13 + 53 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809542 + 7043822 + 10.1093/cid/ciad092 + + +
+ + + 36809536 + + 2023 + 02 + 22 + +
+ + 1941-2452 + + + 2023 + Feb + 21 + + + Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition + Nutr Clin Pract + + Proposal of a nutrition screening algorithm for patients with incurable cancer receiving palliative care: Data from a prospective cohort. + 10.1002/ncp.10953 + + To propose and evaluate the clinical utility of a new nutrition screening algorithm, NutriPal, to detect the degree of nutritional risk in patients with incurable cancer receiving palliative care. + It is a prospective cohort conducted in an oncology palliative care unit. The NutriPal algorithm was used in a three-step process: (i) administration of the Patient-Generated Subjective Global Assessment short form; (ii) calculation of the Glasgow Prognostic Score; and (iii) application of the algorithm to classify patients into four degrees of nutritional risk. The higher the degrees of NutriPal, the worse the nutritional risk, comparing nutritional measures, laboratory data, and overall survival (OS). + The study included 451 patients that were classified using the NutriPal. They were allocated to the degrees: 1 (31.26%), 2 (27.49%), 3 (21.73%), and 4 (19.71%). Statistically significant differences were found in most of the nutritional and laboratory parameters and in OS with each increment in the NutriPal degrees, and OS was reduced (log-rank <0.001). In addition, NutriPal was able to predict a 120-day mortality: there was a significantly higher risk of death in the patients classified as degrees 4 (hazard ratio [HR], 3.03; 95% confidence interval [95% CI], 2.18-4.19), 3 (HR, 2.01; 95% CI, 1.46-2.78), and 2 (HR, 1.42; 95% CI; 1.04-1.95) than in those classified as degree 1. It also showed good predictive accuracy (concordance statistic, 0.76). + The NutriPal is associated to nutritional and laboratory parameters and can predict survival. It could therefore be incorporated into clinical practice for patients with incurable cancer receiving palliative care. + © 2023 American Society for Parenteral and Enteral Nutrition. + + + + Rosa + Karla Santos da Costa + KSDC + http://orcid.org/0000-0002-0951-8725 + + Nutrition and Dietetic Service, National Cancer Institute José Alencar Gomes da Silva, Palliative Care Unit, Rio de Janeiro, Brazil. + + + + Wiegert + Emanuelly Varea Maria + EVM + http://orcid.org/0000-0001-5904-5287 + + Nutrition and Dietetic Service, National Cancer Institute José Alencar Gomes da Silva, Palliative Care Unit, Rio de Janeiro, Brazil. + + + + Oliveira + Livia Costa de + LC + http://orcid.org/0000-0002-5052-1846 + + Nutrition and Dietetic Service, National Cancer Institute José Alencar Gomes da Silva, Palliative Care Unit, Rio de Janeiro, Brazil. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Nutr Clin Pract + 8606733 + 0884-5336 + + IM + + incurable cancer + nutritional screening + nutritional status + palliative care + patient generated subjective global assessment + prognostic + +
+ + + + 2022 + 11 + 23 + + + 2022 + 08 + 15 + + + 2022 + 12 + 18 + + + 2023 + 2 + 22 + 13 + 53 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809536 + 10.1002/ncp.10953 + + + REFERENCES + + Jain R, Coss C, Whooley P, Phelps M, Owen DH. The role of malnutrition and muscle wasting in advanced lung cancer. Curr Oncol Rep. 2020;22(6):54. + + + Zhang Z, Wan Z, Zhu Y, Zhang L, Zhang L, Wan H. Prevalence of malnutrition comparing NRS2002, MUST, and PG-SGA with the GLIM criteria in adults with cancer: a multi-center study. Nutrition. 2021;83:111072. + + + Horie LM, Barrére APN, Castro MG, et al. Diretriz BRASPEN de terapia nutricional no paciente com câncer. BRASPEN J. 2019;34(1):2-32. + + + de Oliveira LC, Abreu GT, Lima LC, Aredes MA, Wiegert EVM. Quality of life and its relation with nutritional status in patients with incurable cancer in palliative care. Supp Care Cancer. 2020;28(10):4971-4978. + + + Muscaritoli M, Arends J, Bachmann P, et al. ESPEN practical guideline: clinical nutrition in cancer. Clin Nutr. 2021;40(5):2898-2913. + + + Correia MITD. Nutrition screening vs nutrition assessment: what's the difference? Nutr Clin Pract. 2018;33(1):62-72. + + + National Oncological Nutrition Consensus. Volume II-revised 2nd edition, expanded and updated. National Institute of Cancer José Alencar Gomes da Silva; 2016. + + + Tisiompanu E. Need for specialized interest in food and nutrition in palliative care. In: Preedy VR, ed. Handbook of nutrition and diet in palliative care. 2nd ed. Boca Raton: Taylor & Francis Group; 2019. + + + Cunha MS, Wiegert EVM, Calixto-Lima L, de Oliveira LC. Validation of the scored Patient-Generated Subjective Global Assessment Short Form as a prognostic tool for incurable cancer patients. JPEN J Parenter Enteral Nutr. 2022;46(4):915-922. + + + Cong M, Song C, Xu H, et al. The patient-generated subjective global assessment is a promising screening tool for cancer cachexia. BMJ Support Palliat Care. 2020;12(e1):e39-e46. + + + Jager-Wittenaar H, Ottery FD. Assessing nutritional status in cancer: role of the Patient-Generated Subjective Global Assessment. Curr Opin Clin Nutr Metab Care. 2017;20(5):322-329. + + + Arends J, Strasser F, Gonella S, et al. Cancer cachexia in adult patients: ESMO clinical practice guidelines. ESMO Open. 2021;6(3):100092. + + + Cederholm T, Jensen GL, Correia MITD, et al. GLIM criteria for the diagnosis of malnutrition-a consensus report from the global clinical nutrition community. Clin Nutr. 2019;38(1):1-9. + + + Dolan RD, McSorley ST, Horgan PG, Laird B, McMillan DC. The role of the systemic inflammatory response in predicting outcomes in patients with advanced inoperable cancer: systematic review and meta-analysis. Crit Rev Oncol Hematol. 2017;116:134-146. + + + Pan M, Zhao Y, He J, et al. Prognostic value of the glasgow prognostic score on overall survival in patients with advanced non-small cell lung cancer. J Cancer. 2021;12(8):2395-2402. + + + Mendes NP, Barros TA, Rosa CdOB, Franceschini SCC. Nutritional screening tools used and validated for cancer patients: a systematic review. Nutr Cancer. 2019;71(6):898-907. + + + Cotogni P, Stragliotto S, Ossola M, Collo A, Riso S, On Behalf Of The Intersociety Italian Working Group For Nutritional Support In Cancer. The role of nutritional support for cancer patients in palliative care. Nutrients. 2021;13(2):306. + + + Schag CC, Heinrich RL, Ganz PA. Karnofsky performance status revisited: reliability, validity, and guidelines. J Clin Oncol. 1984;2(3):187-193. + + + de Pinho NB, Martucci RB, Rodrigues VD, et al. Malnutrition associated with nutrition impact symptoms and localization of the disease: results of a multicentric research on oncological nutrition. Clin Nutr. 2019;38(3):1274-1279. + + + Ottery FD. Definition of standardized nutritional assessment and interventional pathways in oncology. Nutrition. 1996;12(1 Suppl):S15-S19. + + + Gordon CC, Chumlea WC, Roche AF. Stature, recumbent length, and weight. In: Lohman TG, Roche AF, Martorell R, eds. Anthropometric Standardization Reference Manual. Champaign IL: Human Kinetics Books; 1988. + + + Chumlea WMC, Guo SS, Steinbaugh ML. Prediction of stature from knee height for black and white adults and children with application to mobility-impaired or handicapped persons. J Am Diet Assoc. 1994;94(12):1385-1391. + + + da Costa Cunha G, da Costa Rosa KS, Wiegert EV, de Oliveira LC. Clinical relevance and prognostic value of inflammatory biomarkers: a prospective study in terminal cancer patients receiving palliative care. J Pain Symptom Manage. 2021;62(5):978-986. + + + Cordeiro LAF, Silva TH, de Oliveira LC, Neto JFN. Systemic inflammation and nutritional status in patients on palliative cancer care: a systematic review of observational studies. Am J Hosp Palliat Care. 2020;37(7):565-571. + + + Forrest LM, McMillan DC, McArdle CS, Angerson WJ, Dunlop DJ. Evaluation of cumulative prognostic scores based on the systemic inflammatory response in patients with inoperable non-small-cell lung cancer. Br J Cancer. 2003;89(6):1028-1030. + + + McMillan DC. The systemic inflammation-based Glasgow Prognostic Score: a decade of experience in patients with cancer. Cancer Treat Rev. 2013;39(5):534-540. + + + Rosa KSdC, Cypriano RdP, Albuquerque NM, de Oliveira LC. Predictive factors of death on hospitalization in patients with advanced cancer in palliative care. Am J Hosp Palliat Care. 2021;38(10):1189-1194. + + + Wiegert EVM, de Oliveira LC, Calixto-Lima L, Chaves GV, Silva Lopes MS, Peres WAF. New cancer cachexia staging system for use in clinical practice. Nutrition. 2021;90:111271. + + + Hosmer DW, Lemeshow S. Applied logistic regression. 2nd ed. New York: John Wiley & Sons; 2000. + + + Souza Cunha M, Wiegert EVM, Calixto-Lima L, Oliveira LC. Relationship of nutritional status and inflammation with survival in patients with advanced cancer in palliative care. Nutrition. 2018;51-52:98-103. + + + Daly LE, Dolan RD, Power DG, et al. Determinants of quality of life in patients with incurable cancer. Cancer. 2020;126(12):2872-2882. + + + Fearon K, Strasser F, Anker SD, et al. Definition and classification of cancer cachexia: an international consensus. Lancet Oncol. 2011;12(5):489-495. + + + Laviano A, Di Lazzaro L, Koverech A. Nutrition support and clinical outcome in advanced cancer patients. Proc Nutr Soc. 2018;77(4):388-393. + + + Trestini I, Gkountakos A, Carbognin L, et al. Muscle derangement and alteration of the nutritional machinery in NSCLC. Crit Rev Oncol Hematol. 2019;141:43-53. + + + Huang DD, Wu GF, Luo X, et al. Value of muscle quality, strength and gait speed in supporting the predictive power of GLIM-defined malnutrition for postoperative outcomes in overweight patients with gastric cancer. Clin Nutr. 2021;40(6):4201-4208. + + + Carvalho CS, Souza DS, Lopes JR, Castanho IA, Lopes AJ. Relationship between patient-generated subjective global assessment and survival in patients in palliative care. Ann Palliat Med. 2017;6(Suppl 1):S4-S12. + + + Silva GA, Wiegert EVM, Calixto-Lima L, Oliveira LC. Clinical utility of the modified Glasgow Prognostic Score to classify cachexia in patients with advanced cancer in palliative care. Clin Nutr. 2020;39(5):1587-1592. + + + Laird BJA, Fallon M, Hjermstad MJ, et al. Quality of life in patients with advanced cancer: differential association with performance status and systemic inflammatory response. J Clin Oncol. 2016;34(23):2769-2775. + + + Namikawa T, Shimizu S, Yokota K, et al. Neutrophil-to-lymphocyte ratio and C-reactive protein-to-albumin ratio as prognostic factors for unresectable advanced or recurrent gastric cancer. Langenbecks Arch Surg. 2022;407(2):609-621. + + + Zhang J, Zhang C, Li Q, et al. C-reactive protein/albumin ratio is an independent prognostic predictor of survival in advanced cancer patients receiving palliative care. J Palliat Med. 2019;22(12):1536-1545. + + + Park JS, Kim H, Jeung HC, Kang SA. Association between early nutritional risk and overall survival in patients with advanced pancreatic cancer: a single-center retrospective study. Clin Nutr ESPEN. 2019;30:94-99. + + + Li YF, Nie RC, Wu T, et al. Prognostic value of the nutritional risk screening 2002 scale in metastatic gastric cancer: a large-scale cohort study. J Cancer. 2019;10(1):112-119. + + + Zhang Q, Li XR, Zhang X, et al. PG-SGA SF in nutrition assessment and survival prediction for elderly patients with cancer. BMC Geriatr. 2021;21(1):687. + + + Brierley JD, Gospodararowicz MK, Wittekind C. Union for international. Cancer Control (UICC) TNM Classification of Malignant Tumours. 8th ed. Oxford, UK: Wiley Blackwell; 2017. + + + Hui D, Mo L, Paiva CE. The importance of prognostication: impact of prognostic predictions, disclosures, awareness, and acceptance on patient outcomes. Curr Treat Options Oncol. 2021;22(2):12. + + + Jang RW, Caraiscos VB, Swami N, et al. Simple prognostic model for patients with advanced cancer based on performance status. J Oncol Pract. 2014;10(5):e335-e341. + + + Molfino A, Imbimbo G, Laviano A. Current screening methods for the risk or presence of malnutrition in cancer patients. Cancer Manag Res. 2022;14:561-567. + + + Ruggeri E, Giannantonio M, Agostini F, Ostan R, Pironi L, Pannuti R. Home artificial nutrition in palliative care cancer patients: impact on survival and performance status. Clin Nutr. 2020;39(11):3346-3353. + + + Hui D, Paiva CE, Del Fabbro EG, et al. Prognostication in advanced cancer: update and directions for future research. Supp Care Cancer. 2019;27(6):1973-1984. + + + +
+ + + 36809538 + + 2023 + 02 + 22 + +
+ + 1364-548X + + + 2023 + Feb + 21 + + + Chemical communications (Cambridge, England) + Chem Commun (Camb) + + Bromodomain and extraterminal protein-targeted probe enables tumour visualisation in vivo using positron emission tomography. + 10.1039/d2cc04813b + + Bromodomain and extraterminal (BET) proteins, a family of epigenetic regulators, have emerged as important oncology drug targets. BET proteins have not been targeted for molecular imaging of cancer. Here, we report the development of a novel molecule radiolabelled with positron emitting fluorine-18, [18F]BiPET-2, and its in vitro and preclinical evaluation in glioblastoma models. + + + + Dickmann + Catherine G Fitzgerald + CGF + http://orcid.org/0000-0002-8829-5354 + + Bio21 Institute, The University of Melbourne, Parkville, VIC 3010, Australia. whitejm@unimelb.edu.au. + + + Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, and School of Cancer Medicine, La Trobe University, Heidelberg, Australia. uwea@unimelb.edu.au. + + + Department of Molecular Imaging and Therapy, Austin Hospital, Heidelberg, Australia. + + + + McDonald + Alexander F + AF + http://orcid.org/0000-0001-5261-8118 + + Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, and School of Cancer Medicine, La Trobe University, Heidelberg, Australia. uwea@unimelb.edu.au. + + + Department of Molecular Imaging and Therapy, Austin Hospital, Heidelberg, Australia. + + + + Huynh + Nhi + N + + Department of Molecular Imaging and Therapy, Austin Hospital, Heidelberg, Australia. + + + + Rigopoulos + Angela + A + + Department of Molecular Imaging and Therapy, Austin Hospital, Heidelberg, Australia. + + + + Liu + Zhanqi + Z + + Department of Molecular Imaging and Therapy, Austin Hospital, Heidelberg, Australia. + + + + Guo + Nancy + N + + Department of Molecular Imaging and Therapy, Austin Hospital, Heidelberg, Australia. + + + + Osellame + Laura D + LD + http://orcid.org/0000-0001-6174-3797 + + Department of Molecular Imaging and Therapy, Austin Hospital, Heidelberg, Australia. + + + + Gorman + Michael A + MA + http://orcid.org/0000-0003-3438-8245 + + Bio21 Institute, The University of Melbourne, Parkville, VIC 3010, Australia. whitejm@unimelb.edu.au. + + + + Parker + Michael W + MW + http://orcid.org/0000-0002-3101-1138 + + Bio21 Institute, The University of Melbourne, Parkville, VIC 3010, Australia. whitejm@unimelb.edu.au. + + + ACRF Facility for Innovative Cancer Drug Discovery, Bio21 Institute, The University of Melbourne, Parkville, VIC 3010, Australia. + + + ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, VIC 3065, Australia. + + + + Gan + Hui K + HK + http://orcid.org/0000-0001-7319-8546 + + Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, and School of Cancer Medicine, La Trobe University, Heidelberg, Australia. uwea@unimelb.edu.au. + + + + Scott + Andrew M + AM + http://orcid.org/0000-0002-6656-295X + + Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, and School of Cancer Medicine, La Trobe University, Heidelberg, Australia. uwea@unimelb.edu.au. + + + Department of Molecular Imaging and Therapy, Austin Hospital, Heidelberg, Australia. + + + Faculty of Medicine, University of Melbourne, Parkville, Australia. + + + + Ackermann + Uwe + U + http://orcid.org/0000-0001-9259-2258 + + Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, and School of Cancer Medicine, La Trobe University, Heidelberg, Australia. uwea@unimelb.edu.au. + + + Department of Molecular Imaging and Therapy, Austin Hospital, Heidelberg, Australia. + + + + Burvenich + Ingrid J G + IJG + http://orcid.org/0000-0001-8384-2403 + + Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, and School of Cancer Medicine, La Trobe University, Heidelberg, Australia. uwea@unimelb.edu.au. + + + + White + Jonathan M + JM + http://orcid.org/0000-0002-0707-6257 + + Bio21 Institute, The University of Melbourne, Parkville, VIC 3010, Australia. whitejm@unimelb.edu.au. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Chem Commun (Camb) + 9610838 + 1359-7345 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 53 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809538 + 10.1039/d2cc04813b + + +
+ + + 36809541 + + 2023 + 02 + 22 + +
+ + 1600-0684 + + + 2023 + Feb + 21 + + + Journal of medical primatology + J Med Primatol + + Well-differentiated chrondrosarcoma in a cynomolgus macaque (Macaca fascicularis). + 10.1111/jmp.12636 + + A cynomolgus macaque presented with an osteolytic lesion of the left femur. Histopathology was consistent with well-differentiated chondrosarcoma. No metastasis was found in chest radiographs out to 12 months. This case suggests survival out to 1 year without metastasis following amputation may be possible in NHPs with this condition. + © 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. + + + + Walz + Sarah Ruth + SR + https://orcid.org/0000-0002-4735-6499 + + Alpha Genesis Incorporated, Yemassee, South Carolina, USA. + + + + Traslavina + Ryan Patrick + RP + + Antech Diagnostics, Fountain Valley, California, USA. + + + + Ruiz + Byron Fredy + BF + + Antech Diagnostics, Fountain Valley, California, USA. + + + + eng + + Case Reports + + + 2023 + 02 + 21 + +
+ + Denmark + J Med Primatol + 0320626 + 0047-2565 + + IM + + amputation + bone neoplasm + nonhuman primate + +
+ + + + 2023 + 01 + 17 + + + 2022 + 11 + 30 + + + 2023 + 02 + 02 + + + 2023 + 2 + 22 + 13 + 53 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809541 + 10.1111/jmp.12636 + + + REFERENCES + + Riedel RF, Larrier N, Dodd L, Kirsch D, Martinez S, Brigman BE. The clinical management of chondrosarcoma. Curr Treat Options Oncol. 2009;10:94-106. + + + Kim JM, Wong AJ, Lu AJ, Pointdujour-Lim R. Chondrosarcoma metastasis to the choroid. Ocul Oncol Pathol. 2019;5:234-237. + + + Lalam RK, Cassar-Pullicino VN, Kumar N, Cool WP, Cribb GL, Mangham DC. Subcutaneous and lung metastases from chondrosarcoma of the thumb. BJR Case Rep. 2015;1:20150129. + + + Ozaki T, Hillman A, Lindner N, Blasius S, Winkelmann W. Metastasis of chondrosarcoma. J Cancer Res Clin Oncol. 1996;122:625-628. + + + Gelderblom H, Hogendoorn PCW, Dijkstra SD, et al. The clinical approach towards chondrosarcoma. Oncologist. 2008;13:320-329. + + + van Praag VM, Rueten-Budde AJ, Ho V, et al. Incidence, outcomes and prognostic factors during 25 years of treatment of chondrosarcomas. Surg Oncol. 2018;27:402-408. + + + Ma XJ, Dong Y, Zhang CL, Zeng BF. Recurrence analysis in 66 cases with grade I and grade II chondrosarcomas in the extremities. Orthop Surg. 2009;1:132-136. + + + Wang Z, Chen G, Chen X, et al. Predictors of the survival of patients with chondrosarcoma of bone and metastatic disease at diagnosis. J Cancer. 2019;10:2457-2463. + + + Simmons HA, Mattison JA. The incidence of spontaneous neoplasia in two populations of captive rhesus macaques (Macaca mulatta). Antioxid Redox Signal. 2011;14:221-227. + + + Schmelting B, Zöller M, Kaspareit J. Peripheral ossifying fibroma and juxtacortical chondrosarcoma in cynomolgus monkeys (Macaca fascicularis). J Am Assoc Lab Anim Sci. 2011;50:98-104. + + + Chalifoux LV. Chondrosarcoma, squirrel monkey. In: Jones TC, Mohr U, Hunt RD, eds. Nonhuman Primates II. Spinger-Verlag; 1993:128-131. + + + Matthews KA, Strait K, Connor-Stroud F, Courtney CL. Osteochondromatosis in a rhesus macaque (Macaca mulatta). Comp Med. 2012;62:149-152. + + + Damron TA, Ward WG, Stewart A. Osteosarcoma, chondrosarcoma, and Ewing's sarcoma: National Cancer Data Base Report. Clin Orthop Relat Res. 2007;459:40-47. + + + +
+ + + 36809547 + + 2023 + 02 + 22 + +
+ + 1364-548X + + + 2023 + Feb + 21 + + + Chemical communications (Cambridge, England) + Chem Commun (Camb) + + Crystal structure engineering of metal halide perovskites for photocatalytic organic synthesis. + 10.1039/d3cc00468f + + Engineering crystal structure of Cs3BiBr6 and Cs3Bi2Br9 is theoretically and experimentally demonstrated to modulate their photocatalytic performance. This work offers insights into the structure-photoactivity relationships of metal halide perovskites (MHPs) and provides a guideline for exploiting MHPs toward efficient photocatalytic organic synthesis. + + + + Wang + Chunhua + C + + Department of Chemistry, KU Leuven, Celestijnenlaan 200F, Leuven 3001, Belgium. johan.hofkens@kuleuven.be. + + + + Ding + Yang + Y + + Laboratory of Inorganic Materials Chemistry (CMI), University of Namur, 61 rue de Bruxelles, B-5000, Namur, Belgium. + + + + Liu + Biao + B + http://orcid.org/0000-0001-6920-7016 + + Hunan Key Laboratory for Super-microstructure and Ultrafast Process, School of Physics and Electronics, Central South University, Changsha 410083, P. R. China. + + + + Weng + Bo + B + http://orcid.org/0000-0001-8337-219X + + cMACS, Department of Microbial and Molecular Systems, KU Leuven, Celestijnenlaan 200F, Leuven 3001, Belgium. maarten.roeffaers@kuleuven.be. + + + + Hofkens + Johan + J + http://orcid.org/0000-0002-9101-0567 + + Department of Chemistry, KU Leuven, Celestijnenlaan 200F, Leuven 3001, Belgium. johan.hofkens@kuleuven.be. + + + Max Planck Institute for Polymer Research, Ackermannweg 10, Mainz 55128, Germany. + + + + Roeffaers + Maarten B J + MBJ + http://orcid.org/0000-0001-6582-6514 + + cMACS, Department of Microbial and Molecular Systems, KU Leuven, Celestijnenlaan 200F, Leuven 3001, Belgium. maarten.roeffaers@kuleuven.be. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Chem Commun (Camb) + 9610838 + 1359-7345 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 53 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809547 + 10.1039/d3cc00468f + + +
+ + + 36809544 + + 2023 + 02 + 22 + +
+ + 1528-1167 + + + 2023 + Feb + 21 + + + Epilepsia + Epilepsia + + Which is more deleterious to cognitive performance? Interictal epileptiform discharges vs. anti-seizure medication. + 10.1111/epi.17556 + + Children with epilepsy commonly suffer from comorbid neurocognitive impairments that severely impact their psychosocial wellbeing, education, and future career prospects. While the provenance of these deficits is multifactorial, the effects of interictal discharges (IEDs) and anti-seizure medications (ASMs) are thought to be particularly severe. Therefore, although certain ASMs can be leveraged to inhibit IED occurrence, it remains unclear whether epileptiform discharges or the medications themselves are most deleterious to cognition. To examine this question, 25 children undergoing invasive monitoring for refractory focal epilepsy performed one or more sessions of a cognitive flexibility task. Electrophysiological data were recorded to detect IEDs. Between repeated sessions, prescribed ASMs were either continued or titrated to <50% of the baseline dosage. Hierarchical mixed-effects modelling assessed the relationship between task reaction time (RT), IED occurrence, ASM type, and dose while controlling for seizure frequency Both presence (β±SE=49.91±16.55ms, p=0.003) and number of interictal discharges (β±SE=49.84±12.51ms, p<0.001) were associated with slowed task RT. Higher dose oxcarbazepine significantly reduced IED frequency (p=0.009) and improved task performance (β±SE=-107.43±39.54ms, p=0.007). These results emphasize the neurocognitive consequences of IEDs independent of seizure effects. Furthermore, we demonstrate that inhibition of these potentials is associated with improved neurocognitive function following treatment with select ASMs. + This article is protected by copyright. All rights reserved. + + + + Warsi + Nebras M + NM + https://orcid.org/0000-0003-4885-3080 + + Division of Neurosurgery, Hospital for Sick Children, Toronto, ON. + + + Institute of Biomedical Engineering, University of Toronto, Toronto, ON. + + + + Wong + Simeon M + SM + + Institute of Biomedical Engineering, University of Toronto, Toronto, ON. + + + Program in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, ON. + + + + Gorodetsky + Carolina + C + + Division of Neurosurgery, Hospital for Sick Children, Toronto, ON. + + + Division of Neurology, Hospital for Sick Children, Toronto, ON. + + + + Suresh + Hrishikesh + H + + Division of Neurosurgery, Hospital for Sick Children, Toronto, ON. + + + Institute of Biomedical Engineering, University of Toronto, Toronto, ON. + + + + Arski + Olivia N + ON + https://orcid.org/0000-0002-7597-9765 + + Program in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, ON. + + + + Ebden + Mark + M + + Program in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, ON. + + + + Kerr + Elizabeth N + EN + + Program in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, ON. + + + + Smith + Mary Lou + ML + https://orcid.org/0000-0002-1937-1026 + + Program in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, ON. + + + + Yau + Ivanna + I + https://orcid.org/0000-0002-8549-9618 + + Division of Neurology, Hospital for Sick Children, Toronto, ON. + + + + Ochi + Ayako + A + + Division of Neurology, Hospital for Sick Children, Toronto, ON. + + + + Otsubo + Hiroshi + H + + Division of Neurology, Hospital for Sick Children, Toronto, ON. + + + + Sharma + Rohit + R + + Division of Neurology, Hospital for Sick Children, Toronto, ON. + + + + Jain + Puneet + P + https://orcid.org/0000-0002-6009-0859 + + Division of Neurology, Hospital for Sick Children, Toronto, ON. + + + + Weiss + Shelly + S + + Division of Neurology, Hospital for Sick Children, Toronto, ON. + + + + Donner + Elizabeth J + EJ + https://orcid.org/0000-0003-1126-0548 + + Division of Neurology, Hospital for Sick Children, Toronto, ON. + + + + Snead + O Carter + OC + + Division of Neurology, Hospital for Sick Children, Toronto, ON. + + + + Ibrahim + George M + GM + https://orcid.org/0000-0001-9068-8184 + + Division of Neurosurgery, Hospital for Sick Children, Toronto, ON. + + + Institute of Biomedical Engineering, University of Toronto, Toronto, ON. + + + Program in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, ON. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Epilepsia + 2983306R + 0013-9580 + + IM +
+ + + + 2023 + 02 + 20 + + + 2022 + 11 + 15 + + + 2023 + 02 + 20 + + + 2023 + 2 + 22 + 13 + 53 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809544 + 10.1111/epi.17556 + + +
+ + + 36809539 + + 2023 + 02 + 22 + +
+ + 1530-6860 + + 37 + 3 + + 2023 + Mar + + + FASEB journal : official publication of the Federation of American Societies for Experimental Biology + FASEB J + + OASL knockdown inhibits the progression of stomach adenocarcinoma by regulating the mTORC1 signaling pathway. + + e22824 + + 10.1096/fj.202201582R + + The present study investigated the effects of 2'-5' oligoadenylate synthetase-like (OASL) on the biological functions of stomach adenocarcinoma (STAD) cells and tumor formation in nude mice. The differential expression levels of OASL in the different cancer types from TCGA dataset were analyzed using gene expression profiling interactive analysis. Overall survival and the receiver operating characteristic were analyzed using the KM plotter and R, respectively. Furthermore, OASL expression and its effects on the biological functions of STAD cells were detected. The possible upstream transcription factors of OASL were predicted using JASPAR. The downstream signaling pathways of OASL were analyzed using GSEA. Tumor formation experiments were performed to evaluate the effect of OASL on tumor formation in nude mice. The results showed that OASL was highly expressed in STAD tissues and cell lines. OASL knockdown markedly inhibited cell viability, proliferation, migration, and invasion and accelerated STAD cell apoptosis. Conversely, OASL overexpression had the opposite effect on STAD cells. JASPAR analysis revealed that STAT1 is an upstream transcription factor of OASL. Furthermore, GSEA showed that OASL activated the mTORC1 signaling pathway in STAD. The protein expression levels of p-mTOR and p-RPS6KB1 were suppressed by OASL knockdown and promoted by OASL overexpression. The mTOR inhibitor, rapamycin, markedly reversed the effect of OASL overexpression on STAD cells. Additionally, OASL promoted tumor formation and increased tumor weight and volume in vivo. In conclusion, OASL knockdown suppressed the proliferation, migration, invasion, and tumor formation of STAD cells by inhibiting the mTOR signaling pathway. + © 2023 Federation of American Societies for Experimental Biology. + + + + Zhao + Weizhu + W + + Department of Radiology, Shandong University Cancer Center, Jinan, China. + + + Department of Oncology, Binzhou People's Hospital Affiliated to Shandong First Medical University, Binzhou, China. + + + + Yang + Haiying + H + + Department of Cardiology, Binzhou People's Hospital Affiliated to Shandong First Medical University, Binzhou, China. + + + + Liu + Luguang + L + + Department of Gastroenterological surgery, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Shandong Cancer Hospital Affiliated to Shandong First Medical University, Jinan, China. + + + + Qu + Xianlin + X + + Department of Gastroenterological surgery, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Shandong Cancer Hospital Affiliated to Shandong First Medical University, Jinan, China. + + + + Ding + Jishuang + J + + Department of Gastroenterological surgery, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Shandong Cancer Hospital Affiliated to Shandong First Medical University, Jinan, China. + + + + Yu + Hang + H + + Department of Gastroenterological surgery, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Shandong Cancer Hospital Affiliated to Shandong First Medical University, Jinan, China. + + + + Xu + Botao + B + + Department of Gastroenterological surgery, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Shandong Cancer Hospital Affiliated to Shandong First Medical University, Jinan, China. + + + + Zhao + Siwei + S + + Department of Gastroenterological surgery, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Shandong Cancer Hospital Affiliated to Shandong First Medical University, Jinan, China. + + + + Xi + Guangmin + G + + College of Life Science, Qi Lu Normal University, Jinan, China. + + + + Xing + Ligang + L + + Department of Radiology, Shandong University Cancer Center, Jinan, China. + + + Department of Radiology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Shandong Cancer Hospital Affiliated to Shandong First Medical University, Jinan, China. + + + + Chai + Jie + J + https://orcid.org/0000-0001-6702-7222 + + Department of Gastroenterological surgery, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Shandong Cancer Hospital Affiliated to Shandong First Medical University, Jinan, China. + + + + eng + + + XJ202202505 + Hospital level project of Binzhou people's Hospital + + + + 2019ZZZY011008 + Major innovation project of science and technology of shandong province + + + + ZR2021MH108 + Natural Science Foundation of Shandong Province (Natural Science Foundation of Shandong) + + + + + Journal Article + +
+ + United States + FASEB J + 8804484 + 0892-6638 + + IM + + 2′-5′ oligoadenylate synthetase-like + STAT1 + mTORC1 pathway + proliferation + stomach adenocarcinoma + +
+ + + + 2023 + 01 + 12 + + + 2022 + 09 + 30 + + + 2023 + 02 + 01 + + + 2023 + 2 + 22 + 13 + 53 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809539 + 10.1096/fj.202201582R + + + REFERENCES + + Wang H, Shen L, Li Y, Lv J. Integrated characterisation of cancer genes identifies key molecular biomarkers in stomach adenocarcinoma. J Clin Pathol. 2020;73(9):579-586. + + + Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209-249. + + + Suzuki H, Oda I, Abe S, et al. High rate of 5-year survival among patients with early gastric cancer undergoing curative endoscopic submucosal dissection. Gastric Cancer. 2016;19(1):198-205. + + + Allemani C, Weir HK, Carreira H, et al. Global surveillance of cancer survival 1995-2009: analysis of individual data for 25,676,887 patients from 279 population-based registries in 67 countries (CONCORD-2). Lancet. 2015;385(9972):977-1010. + + + Digklia A, Wagner AD. Advanced gastric cancer: current treatment landscape and future perspectives. World J Gastroenterol. 2016;22(8):2403-2414. + + + Zeng Y, Jin RU. Molecular pathogenesis, targeted therapies, and future perspectives for gastric cancer. Semin Cancer Biol. 2021;86(Pt3):566-582. + + + Gallo A, Ronzio M, Bezzecchi E, Mantovani R, Dolfini D. NF-Y subunits overexpression in gastric adenocarcinomas (STAD). Sci Rep. 2021;11(1):23764. + + + Soleimani F, Hajjari M, Mohammad Soltani B, Behmanesh M. Up-regulation of FOXC2 and FOXQ1 is associated with the progression of gastric-type adenocarcinoma. Cell J. 2017;19(Suppl 1):66-71. + + + Zeng C, Feng X, Wang W, et al. Decreased expression of insulin-like growth factor binding protein 6 is associated with gastric adenocarcinoma prognosis. Oncol Lett. 2017;13(6):4161-4168. + + + Xu Y, Yang X, Li Z, et al. Sprouty2 correlates with favorable prognosis of gastric adenocarcinoma via suppressing FGFR2-induced ERK phosphorylation and cancer progression. Oncotarget. 2017;8(3):4888-4900. + + + Kristiansen H, Gad HH, Eskildsen-Larsen S, Despres P, Hartmann R. The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities. J Interferon Cytokine Res. 2011;31(1):41-47. + + + Hartmann R, Justesen J, Sarkar SN, Sen GC, Yee VC. Crystal structure of the 2′-specific and double-stranded RNA-activated interferon-induced antiviral protein 2′-5′-oligoadenylate synthetase. Mol Cell. 2003;12(5):1173-1185. + + + Sim CK, Cho YS, Kim BS, Baek IJ, Kim YJ, Lee MS. 2′-5' Oligoadenylate synthetase-like 1 (OASL1) deficiency in mice promotes an effective anti-tumor immune response by enhancing the production of type I interferons. Cancer Immunol Immunother. 2016;65(6):663-675. + + + Lv J, Wang L, Shen H, Wang X. Regulatory roles of OASL in lung cancer cell sensitivity to Actinidia chinensis planch root extract (acRoots). Cell Biol Toxicol. 2018;34(3):207-218. + + + Yu C, Xue P, Zhang L, et al. Prediction of key genes and pathways involved in trastuzumab-resistant gastric cancer. World J Surg Oncol. 2018;16(1):174. + + + Zhang Y, Yu C. Prognostic characterization of OAS1/OAS2/OAS3/OASL in breast cancer. BMC Cancer. 2020;20(1):575. + + + Chen S, Sun Z, Zhao W, et al. Oligoadenylate synthetases-like is a prognostic biomarker and therapeutic target in pancreatic ductal adenocarcinoma. Ann Transl Med. 2022;10(3):138. + + + Recio-Boiles A, Babiker HM. Gastric Cancer. StatPearls; 2022. + + + Tan Z. Recent advances in the surgical treatment of advanced gastric cancer: a review. Med Sci Monit. 2019;25:3537-3541. + + + Li K, Zhang A, Li X, Zhang H, Zhao L. Advances in clinical immunotherapy for gastric cancer. Biochim Biophys Acta Rev Cancer. 2021;1876(2):188615. + + + Qin ZY, Wang T. BRD4 promotes gastric cancer progression and metastasis through acetylation-dependent stabilization of snail. Cancer Res. 2019;79(19):4869-4881. + + + Gao LJ, Li JL, Yang RR, et al. Biological characterization and clinical value of OAS gene family in pancreatic cancer. Front Oncol. 2022;12:884334. + + + Choi UY, Kang JS, Hwang YS, Kim YJ. Oligoadenylate synthase-like (OASL) proteins: dual functions and associations with diseases. Exp Mol Med. 2015;47:e144. + + + Lu L, Wang H, Fang J, et al. Overexpression of OAS1 is correlated with poor prognosis in pancreatic cancer. Front Oncol. 2022;12:944194. + + + Huang YZ, Zheng YX, Zhou Y, et al. OAS1, OAS2, and OAS3 contribute to epidermal keratinocyte proliferation by regulating cell cycle and augment type I interferon-induced JAK1-STAT1 phosphorylation in psoriasis. J Invest Dermatol. 2022;142:2635-2645.e9. + + + Zhu J, Zhang Y, Ghosh A, et al. Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor. Immunity. 2014;40(6):936-948. + + + Ghosh A, Shao L, Sampath P, et al. Oligoadenylate-Synthetase-family protein OASL inhibits activity of the DNA sensor cGAS during DNA virus infection to limit interferon production. Immunity. 2019;50(1):51-63. + + + Zhu J, Ghosh A, Sarkar SN. OASL-a new player in controlling antiviral innate immunity. Curr Opin Virol. 2015;12:15-19. + + + Gao F, Tan Y, Luo H. MALAT1 is involved in type I IFNs-mediated systemic lupus erythematosus by up-regulating OAS2, OAS3, and OASL. Braz J Med Biol Res. 2020;53(5):e9292. + + + Li X, Sun G, Wu L, et al. Upregulation of ADAR promotes breast cancer progression and serves as a potential therapeutic target. J Oncol. 2021;27:2012903. + + + Salaffi F, Giacobazzi G, Di Carlo M. Chronic pain in inflammatory arthritis: mechanisms, metrology, and emerging targets-a focus on the JAK-STAT pathway. Pain Res Manag. 2018;2018:8564215. + + + O'Shea JJ, Holland SM, Staudt LM. JAKs and STATs in immunity, immunodeficiency, and cancer. N Engl J Med. 2013;368(2):161-170. + + + Zhang H, Zhu C, He Z, Chen S, Li L, Sun C. LncRNA PSMB8-AS1 contributes to pancreatic cancer progression via modulating miR-382-3p/STAT1/PD-L1 axis. J Exp Clin Cancer Res. 2020;39(1):179. + + + Qadir AS, Ceppi P, Brockway S, et al. CD95/Fas increases Stemness in cancer cells by inducing a STAT1-dependent type I interferon response. Cell Rep. 2017;18(10):2373-2386. + + + Li X, Pan K, Vieth M, Gerhard M. JAK-STAT1 signaling pathway is an early response to helicobacter pylori infection and contributes to immune escape and gastric. Carcinogenesis. 2022;23(8):4147. + + + Lei M, Siemers NO, Pandya D, et al. Analyses of PD-L1 and inflammatory gene expression association with efficacy of Nivolumab +/− Ipilimumab in gastric cancer/gastroesophageal junction cancer. Clin Cancer Res. 2021;27(14):3926-3935. + + + Liang R, Chen W, Chen XY, Fan HN, Zhang J, Zhu JS. Dihydroartemisinin inhibits the tumorigenesis and invasion of gastric cancer by regulating STAT1/KDR/MMP9 and P53/BCL2L1/CASP3/7 pathways. Pathol Res Pract. 2021;218:153318. + + + Li G, Zhang Z, Chen Z, Liu B, Wu H. LncRNA DLEU2 is activated by STAT1 and induces gastric cancer development via targeting miR-23b-3p/NOTCH2 axis and NOTCH signaling pathway. Life Sci. 2021;277:119419. + + + Zhang X, Wang S, Wang H, et al. Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1/mTOR pathway. Mol Cancer. 2019;18(1):20. + + + Pópulo H, Lopes JM, Soares P. The mTOR signalling pathway in human cancer. Int J Mol Sci. 2012;13(2):1886-1918. + + + Ge Y, Li Q, Lin L, et al. Downregulation of NUSAP1 suppresses cell proliferation, migration, and invasion via inhibiting mTORC1 signalling pathway in gastric cancer. Cell Biochem Funct. 2020;38(1):28-37. + + + +
+ + + 36809543 + + 2023 + 02 + 22 + +
+ + 1099-1573 + + + 2023 + Feb + 21 + + + Phytotherapy research : PTR + Phytother Res + + Therapeutic and cosmeceutical role of glycosylated natural products in dermatology. + 10.1002/ptr.7752 + + Natural products (NPs) remain the primary source of pharmacologically active candidates for drug discovery. Since time immemorial, NPs have attracted considerable attention because of their beneficial skin effects. Moreover, there has been a great interest in using such products for the cosmetics industry in the past few decades, bridging the gap between modern and traditional medicine. Terpenoids, Steroids, and Flavonoids having glycosidic attachment have proven biological effects with a positive impact on human health. NPs derived glycosides are mainly found in fruits, vegetables, and plants, and most of them have a special reverence in traditional and modern medicine for disease prevention and treatment. A literature review was performed using scientific journals, Google scholar, Scifinder, PubMED, and Google patents. These scientific articles, documents, and patents establish the significance of glycosidic NPs in the areas of dermatology. Considering the human inclination to the usage of NPs rather than synthetic or inorganic drugs (especially in the area of skin care), in the present review we have discussed the worth of NP glycosides in beauty care and skin-related therapeutics and the mechanistic pathways involved. + © 2023 John Wiley & Sons Ltd. + + + + Kumar + Amit + A + + Natural Product and Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India. + + + Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India. + + + PK/PD divisions, CSIR-Indian Institute of Integrative Medicine, Jammu, India. + + + + Kaur + Sarabjit + S + + Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India. + + + + Sangwan + Pyare L + PL + + Natural Product and Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India. + + + + Tasduq + Sheikh A + SA + https://orcid.org/0000-0001-6474-1009 + + PK/PD divisions, CSIR-Indian Institute of Integrative Medicine, Jammu, India. + + + PK-PD and Toxicology Divisions, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India. + + + + eng + + + HCP007 + Council of Scientific and Industrial Research + + + + GAP2166 + Department of Biotechnology, Ministry of Science and Technology, India + + + + + Journal Article + Review + + + 2023 + 02 + 21 + +
+ + England + Phytother Res + 8904486 + 0951-418X + + IM + + mechanistic pathways + natural product glycoside + skin pathologies + ultraviolet radiations + +
+ + + + 2022 + 09 + 03 + + + 2022 + 02 + 08 + + + 2022 + 10 + 09 + + + 2023 + 2 + 22 + 13 + 53 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809543 + 10.1002/ptr.7752 + + + REFERENCES + + Arung, E. T., Furuta, S., Ishikawa, H., Kusuma, I. W., Shimizu, K., & Kondo, R. (2011). Anti-melanogenesis properties of quercetin- and its derivative-rich extract from Allium cepa. Food Chemistry, 124, 1024-1028. + + + Avila Acevedo, J. G., Espinosa González, A. M., Benitez Flores, J. D. C., Delgado, T. H., Maya, S. F., Contreras, J. C., … García Bores, A. M. (2014). Photoprotection of Buddleja cordata extract against UVB-induced skin damage in SKH-1 hairless mice. BMC Complementary and Alternative Medicine, 14, 1-9. + + + Baltina, L. (2003). Chemical modification of glycyrrhizic acid as a route to new bioactive compounds for medicine. Current Medicinal Chemistry, 10, 155-171. + + + Bechara, R., Nabhan, M., Antonios, D., Azouri, H., & Pallardy, M. (2018). 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+ + 1753-4887 + + + 2023 + Feb + 21 + + + Nutrition reviews + Nutr Rev + + Commentary: When applying dietary therapies for gastrointestinal conditions, family values, culture, and social challenges matter. + nuad014 + 10.1093/nutrit/nuad014 + + Some gastrointestinal conditions now have diet as a cornerstone to therapy. Three examples include the low-fermentable, oligosaccharide, disaccharide, monosaccharide, and polyol diet for irritable bowel syndrome, a gluten-free diet for celiac disease, and a hypoallergenic diet for eosinophilic esophagitis. All have been shown to be effective in Western or highly industrialized countries. However, these gastrointestinal conditions occur worldwide. Less is known regarding the effectiveness of dietary therapies in cultures and regions of dense religious and traditional practices where food is a central focus. This includes South Asia, the Mediterranean region, Africa, the Middle East, South America, and within Indigenous communities. Hence, there is a need to reproduce dietary intervention studies within cultures of dense traditional dietary practices to understand the applicability and acceptability of dietary therapy to establish generalizability. Furthermore, there is a need for nutrition experts to have a deep understanding of various cultural cuisines, practices, values, and customs. To achieve this, increasing the diversity of students in the sciences and having a diverse workforce of nutrition experts and health professionals that reflects the patient population will allow for more personalized care. In addition, there are social challenges, including a lack of medical insurance coverage, the cost of dietary interventions, and inconsistent nutrition messaging. Although there are many cultural considerations and social challenges to implementing effective dietary interventions around the world, these barriers are addressable through research methodologies that address culture and society challenges, and enhanced training of dietitians. + © The Author(s) 2023. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. + + + + Iacovou + Marina + M + 0000-0001-5209-0624 + + Centre of Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, and the Department of Molecular and Translational Science, Monash University, Clayton, Victoria, Australia. + + + + Lewis + James D + JD + + Division of Gastroenterology and Hepatology, University of Pennsylvania, Philadelphia, Pennsylvania, USA. + + + + eng + + + APP2000701 + National Health and Medical Research Council + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Nutr Rev + 0376405 + 0029-6643 + + IM + + acceptability + applicability + culture + dietary therapies + gastrointestinal + +
+ + + + 2023 + 2 + 22 + 13 + 53 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809548 + 7049589 + 10.1093/nutrit/nuad014 + + +
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+ + 1468-4373 + + + 2023 + Feb + 21 + + + Journal of the history of medicine and allied sciences + J Hist Med Allied Sci + + Histories of Medieval Plague in Renaissance Italy. + jrad001 + 10.1093/jhmas/jrad001 + + During the sixteenth century, Italian scholars revised their conception of the field of history so that its purposes went beyond providing political and morally edifying narratives. These scholars contended that history must also account for culture and nature in an encyclopedic fashion. In the same years, numerous newly available texts from antiquity, the Byzantine empire, and the Middle Ages provided insight into the character of earlier outbreaks of plague. Italian physicians, embracing new visions of the field of history, the culture of humanism, and an inductivist epistemology, used these texts to argue that there were continuities among ancient, medieval, and Renaissance epidemics. They catalogued plague and formed historical categories based on severity and perceived origins, leading to the rejection of the conclusions of fourteenth-century western Europeans who viewed the plague of 1347-1353 as unprecedented. These erudite physicians saw medieval plague to be one example of the extreme epidemics that have regularly occurred throughout history. + © The Author(s) 2023. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com. + + + + Martin + Craig + C + 0000-0001-7663-4841 + + Ca' Foscari University of Venice, Italy. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + J Hist Med Allied Sci + 0413415 + 0022-5045 + + IM + + Girolamo Cardano + Girolamo Mercuriale + Plague + Renaissance humanism + epidemics + epistemology + historiography + +
+ + + + 2023 + 2 + 22 + 13 + 53 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809553 + 7049695 + 10.1093/jhmas/jrad001 + + +
+ + + 36809545 + + 2023 + 02 + 22 + +
+ + 1538-3598 + + + 2023 + Feb + 21 + + + JAMA + JAMA + + Attacks on Health Care Used as a Weapon of War in Ukraine and Globally: The Demand for Accountability. + 10.1001/jama.2023.2787 + + + Heisler + Michele + M + + Physicians for Human Rights, New York, New York. + + + Department of Internal Medicine, University of Michigan, Ann Arbor. + + + + Kovtonyuk + Pavlo + P + + Ukrainian Healthcare Center, Kyiv, Ukraine. + + + + De Vos + Christian + C + + Physicians for Human Rights, New York, New York. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + JAMA + 7501160 + 0098-7484 + + IM + + In this Viewpoint, authors from Physicians for Human Rights and the Ukrainian Healthcare Center present findings from a joint report documenting the attacks on health care workers and facilities as a weapon of war in the Russian war with Ukraine. + +
+ + + + 2023 + 2 + 22 + 13 + 53 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809545 + 2801937 + 10.1001/jama.2023.2787 + + +
+ + + 36809551 + + 2023 + 02 + 22 + +
+ + 1473-0189 + + + 2023 + Feb + 21 + + + Lab on a chip + Lab Chip + + Introduction to Lab on a Chip Reviews issue. + 10.1039/d3lc90019c + + + Wheeler + Aaron R + AR + http://orcid.org/0000-0001-5230-7475 + + University of Toronto, Canada. aaron.wheeler@utoronto.ca. + + + + Ross + Philippa + P + + Royal Society of Chemistry, Cambridge, UK. + + + + eng + + Editorial + + + 2023 + 02 + 21 + +
+ + England + Lab Chip + 101128948 + 1473-0189 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 53 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809551 + 10.1039/d3lc90019c + + +
+ + + 36809555 + + 2023 + 02 + 22 + +
+ + 1463-1326 + + + 2023 + Feb + 21 + + + Diabetes, obesity & metabolism + Diabetes Obes Metab + + Change in albuminuria as a surrogate endpoint for cardiovascular and renal outcomes in patients with diabetes. + 10.1111/dom.15030 + + For the purpose of predicting clinical outcomes in patients with diabetes and chronic kidney disease, change in albuminuria is a good candidate to be a surrogate marker for future cardiovascular events and progression of kidney disease. Spot urine albumin:creatinine ratio is convenient and recognized as a viable alternative to 24-hour albumin, with some limitations. Although there is sufficient evidence to validate its use in clinical trials as a surrogate endpoint for renal outcomes, this is not yet the case for cardiovascular outcomes. While change in albuminuria as a primary or secondary endpoint is trial-specific, its use should be encouraged, nonetheless. This article is protected by copyright. All rights reserved. + This article is protected by copyright. All rights reserved. + + + + Palmer + Biff F + BF + + University of Texas Southwestern Medical Center, Dallas, TX, USA. + + + + eng + + Journal Article + Review + + + 2023 + 02 + 21 + +
+ + England + Diabetes Obes Metab + 100883645 + 1462-8902 + + IM + + albuminuria + cardiovascular disease + chronic kidney disease + diabetes complications + diabetic nephropathy + effectiveness + type 2 diabetes mellitus + +
+ + + + 2023 + 02 + 10 + + + 2022 + 11 + 04 + + + 2023 + 02 + 19 + + + 2023 + 2 + 22 + 13 + 54 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809555 + 10.1111/dom.15030 + + +
+ + + 36809549 + + 2023 + 02 + 22 + +
+ + 1521-4095 + + + 2023 + Feb + 21 + + + Advanced materials (Deerfield Beach, Fla.) + Adv Mater + + Catalytic Amounts of an Antibacterial Monomer Enable the Upcycling of Poly(Ethylene Terephthalate) Waste. + + e2210758 + + 10.1002/adma.202210758 + + Poly(ethylene terephthalate) (PET) is an important polymer with an annual output second only to polyethylene. The development of PET recycling technologies is therefore necessary to not only eliminate the harm associated with white pollution and microplastics, but also to reduce carbon emissions. Antibacterial PET, one of the most high-value advanced materials, has improved our ability to treat bacterial infections. However, current methods of manufacturing commercial antibacterial PET require blending with an excess of metal-based antibacterial agents, which leads to biotoxicity and a nonpersistent antibacterial activity. In addition, high-efficiency organic antibacterial agents have yet to be employed in antibacterial PET due to their poor thermal stabilities. Herein, we describe a solid-state reaction for the upcycling of PET waste using a novel hyperthermostable antibacterial monomer. This reaction is catalyzed by the residual catalyst present in the PET waste. It was found that a catalytic amount of the antibacterial monomer enabled the low-cost upcycling of PET waste to produce high-value recycled PET with a strong and persistent antibacterial activity, as well as similar thermal properties to the virgin PET. This work provides a feasible and economic strategy for the large-scale upcycling of PET waste, and exhibits potential for application in the polymer industry. This article is protected by copyright. All rights reserved. + This article is protected by copyright. All rights reserved. + + + + Zhang + Hongjie + H + + MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, P. R. China. + + + + Fang + Tianxiang + T + + MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, P. R. China. + + + + Yao + Xuxia + X + + School of Materials Science and Engineering, Zhejiang University, Hangzhou, 310027, P. R. China. + + + + Li + Xiaodong + X + + Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Hangzhou, 310000, P. R. China. + + + + Zhu + Weipu + W + https://orcid.org/0000-0002-6662-5543 + + MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, P. R. China. + + + Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering, Hangzhou, P. R. China. + + + Key Laboratory of Adsorption and Separation Materials & Technologies of Zhejiang Province, Zhejiang University, Hangzhou, 310027, P. R. China. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Adv Mater + 9885358 + 0935-9648 + + IM + + antibacterial monomer + poly(ethylene terephthalate) + solid-state reaction + upcycling + +
+ + + + 2023 + 01 + 15 + + + 2022 + 11 + 19 + + + 2023 + 2 + 22 + 13 + 53 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809549 + 10.1002/adma.202210758 + + +
+ + + 36809557 + + 2023 + 02 + 22 + +
+ + 1445-2197 + + + 2023 + Feb + 21 + + + ANZ journal of surgery + ANZ J Surg + + Transfixation of the elbow joint for upper limb salvage. + 10.1111/ans.18291 + + + Murphy + Nicholas J + NJ + + Department of Traumatology, John Hunter Hospital & University of Newcastle, Newcastle, New South Wales, Australia. + + + + Balogh + Zsolt J + ZJ + https://orcid.org/0000-0002-0277-4822 + + Department of Traumatology, John Hunter Hospital & University of Newcastle, Newcastle, New South Wales, Australia. + + + + eng + + Case Reports + + + 2023 + 02 + 21 + +
+ + Australia + ANZ J Surg + 101086634 + 1445-1433 + + IM +
+ + + + 2022 + 12 + 06 + + + 2023 + 01 + 08 + + + 2023 + 2 + 22 + 13 + 54 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809557 + 10.1111/ans.18291 + + + References + + Nayar SK, Alcock HMF, Edwards DS. Primary amputation versus limb salvage in upper limb major trauma: a systematic review. Eur. J. Orthop. Surg. Traumatol. 2022; 32: 395-403. + + + Otto IA, Kon M, Schuurman AH, van Minnen LP. Replantation versus prosthetic fitting in traumatic arm amputations: a systematic review. PLoS One 2015; 10: e0137729. + + + Pet MA, Morrison SD, Mack JS et al. Comparison of patient-reported outcomes after traumatic upper extremity amputation: replantation versus prosthetic rehabilitation. Injury 2016; 47: 2783-8. + + + Liu DS, Sofiadellis F, Ashton M, MacGill K, Webb A. Early soft tissue coverage and negative pressure wound therapy optimises patient outcomes in lower limb trauma. Injury 2012; 43: 772-8. + + + +
+ + + 36809554 + + 2023 + 02 + 22 + +
+ + 1099-1166 + + + 2023 + Feb + 21 + + + International journal of geriatric psychiatry + Int J Geriatr Psychiatry + + Effects of Types and levels of social capital on emotional well-being for older people in Indonesia: A longitudinal study. + + e5891 + + 10.1002/gps.5891 + + The purpose of this study was to examine the effects of different types and levels of social capital and emotional well-being in older adults in Indonesia by a longitudinal data. + The 4th and the 5th waves of Indonesian Family Life Survey (IFLS) data were used for this study. The participants aged 60 years or older who participated in both waves were included for analysis (n=1,374). Depressive symptoms and happiness were used to assess emotional well-being. Cognitive social capital (neighborhood trust) and structural social capital (participating in arisan, community meetings, volunteers, village improvement programs, and religious activities) were the main independent variables. The generalized estimating equations (GEE) model was used for analysis. + Participation in arisan (B= -0.534) and attending religious activities (B=-0.591) were related to lower depressive symptoms, but the effect of religious activities would offset over time. Both a low or high social participation showed protective effects on depressive symptoms at the intercept and the time slope. Having higher neighborhood trust was related to more chance of feeling very happy (OR=1.518). + Structural social capital is protective from depressive symptoms, while cognitive social capital contributes to happiness. Facilitating social participation and improving neighborhood trust through policies and programs is suggested to promote emotional well-being for older people. + This article is protected by copyright. All rights reserved. + + + + Ekadinata + Nopryan + N + + School of Public Health, Taipei Medical University, Taipei, Taiwan. + + + + Hsu + Hui-Chuan + HC + https://orcid.org/0000-0002-3830-2480 + + School of Public Health, Taipei Medical University, Taipei, Taiwan. + + + Research Center of Health Equity, College of Public Health, Taipei Medical University, Taipei, Taiwan. + + + + Chuang + Ying-Chih + YC + + School of Public Health, Taipei Medical University, Taipei, Taiwan. + + + Research Center of Health Equity, College of Public Health, Taipei Medical University, Taipei, Taiwan. + + + + Chao + Shiau-Fang + SF + + Department of Social Work, National Taiwan University, Taipei, Taiwan. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Int J Geriatr Psychiatry + 8710629 + 0885-6230 + + IM + + depressive symptoms + happiness + older adults + social capital + social participation + trust + +
+ + + + 2022 + 10 + 07 + + + 2023 + 02 + 19 + + + 2023 + 2 + 22 + 13 + 53 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809554 + 10.1002/gps.5891 + + +
+ + + 36809552 + + 2023 + 02 + 22 + +
+ + 1531-8257 + + + 2023 + Feb + 21 + + + Movement disorders : official journal of the Movement Disorder Society + Mov Disord + + Atrophin-1 Function and Dysfunction in Dentatorubral-Pallidoluysian Atrophy. + 10.1002/mds.29355 + + Dentatorubral-pallidoluysian atrophy (DRPLA) is a rare, incurable genetic disease that belongs to the group of polyglutamine (polyQ) diseases. DRPLA is the most common in the Japanese population; however, its global prevalence is also increasing due to better clinical recognition. It is characterized by cerebellar ataxia, myoclonus, epilepsy, dementia, and chorea. DRPLA is caused by dynamic mutation of CAG repeat expansion in ATN1 gene encoding the atrophin-1 protein. In the cascade of molecular disturbances, the pathological form of atrophin-1 is the initial factor, which has not been precisely characterized so far. Reports indicate that DRPLA is associated with disrupted protein-protein interactions (in which an expanded polyQ tract plays a crucial role), as well as gene expression deregulation. There is a great need to design efficient therapy that would address the underlying neurodegenerative process and thus prevent or alleviate DRPLA symptoms. An in-depth understanding of the normal atrophin-1 function and mutant atrophin-1 dysfunction is crucial for this purpose. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. + © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. + + + + Nowak + Bartosz + B + + Department of Medical Biotechnology, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland. + + + + Kozlowska + Emilia + E + + Department of Medical Biotechnology, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland. + + + + Pawlik + Weronika + W + + Department of Medical Biotechnology, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland. + + + + Fiszer + Agnieszka + A + https://orcid.org/0000-0001-7829-1926 + + Department of Medical Biotechnology, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland. + + + + eng + + + DI2019 004349 + Ministerstwo Edukacji i Nauki + + + + 2021/41/B/NZ3/03803 + Narodowe Centrum Nauki + + + + + Journal Article + Review + + + 2023 + 02 + 21 + +
+ + United States + Mov Disord + 8610688 + 0885-3185 + + IM + + CAG repeats + atrophin-1 + dentatorubral-pallidoluysian atrophy + neurodegeneration + polyglutamine diseases + +
+ + + + 2023 + 01 + 19 + + + 2022 + 09 + 24 + + + 2023 + 01 + 31 + + + 2023 + 2 + 22 + 13 + 53 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809552 + 10.1002/mds.29355 + + + References + + Bunting EL, Hamilton J, Tabrizi SJ. Polyglutamine diseases. Curr Opin Neurobiol 2022;72:39-47. https://doi.org/10.1016/J.CONB.2021.07.001 + + + Stoyas CA, La Spada AR. The CAG-polyglutamine repeat diseases: a clinical, molecular, genetic, and pathophysiologic nosology. Handb Clin Neurol 2018;147:143-170. https://doi.org/10.1016/B978-0-444-63233-3.00011-7 + + + Fan HC, Ho LI, Chi CS, Chen SJ, Peng GS, Chan TM, et al. Polyglutamine (PolyQ) diseases: genetics to treatments. Cell Transplant 2014;23:441-458. https://doi.org/10.3727/096368914X678454 + + + Tsuji S, Onodera O, Goto JUN, Nishizawa M. Sporadic ataxias in Japan-a population-based epidemiological study. Cerebellum 2008;7:189-197. https://doi.org/10.1007/s12311-008-0028-x + + + Takano H, Cancel G, Ikeuchi T, Lorenzetti D, Mawad R, Stevanin G, et al. Close associations between prevalences of dominantly inherited spinocerebellar ataxias with CAG-repeat expansions and frequencies of large Normal CAG alleles in Japanese and Caucasian populations. Am J Hum Genet 1998;63:1060-1066. https://doi.org/10.1086/302067 + + + Lee I, Soong B, Lu Y, Chang Y. Dentatorubropallidoluysian atrophy in Chinese. Arch Neurol 2001;58(11):1905-1908. https://doi.org/10.1001/archneur.58.11.1905 + + + Chaudhry A, Anthanasiou-Fragkouli A, Houlden H. DRPLA: understanding the natural history and developing biomarkers to accelerate therapeutic trials in a globally rare repeat expansion disorder. J Neurol 2020;268:3031-3041. https://doi.org/10.1007/s00415-020-10218-6 + + + Bhanushali AA, Venkatesan R, Das BR. Spinocerebellar ataxias in India: three-year molecular data from a central reference laboratory. 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A shared haplotype for dentatorubropallidoluysian atrophy (DRPLA) in Italian families testifies of the recent introduction of the mutation. J Hum Genet 2014;59:153-157. https://doi.org/10.1038/jhg.2013.137 + + + Cox H, Costin-kelly NM, Ramani P, Whitehouse WP. An established case of dentatorubral pallidoluysian atrophy (DRPLA) with unusual features on muscle biopsy. Eur J Paediatr Neurol 2000;4:119-123. https://doi.org/10.1053/ejpn.2000.0279 + + + Wardle M, Majounie E, Williams NM, Rosser AE, Morris HR, Robertson NP. Dentatorubral pallidoluysian atrophy in South Wales. J Neurol Neurosurg Psychiatry 2008;79:804-807. https://doi.org/10.1136/jnnp.2007.128074 + + + Infante J, Combarros O, Volpini V, Corral J, Llorca J, Berciano J. Autosomal dominant cerebellar ataxias in Spain: molecular and clinical correlations, prevalence estimation and survival analysis. 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Hum Mol Genet 1995;4:663-666. https://doi.org/10.1093/hmg/4.4.663 + + + Takano H, Onodera O, Takahashi H, Igarashi S, Yamada M, Oyake M, et al. Somatic mosaicism of expanded CAG repeats in brains of patients with dentatorubral-pallidoluysian atrophy: cellular population-dependent dynamics of mitotic instability. Am J Hum Genet 1996;58:1212-1222. + + + Margolis RL, Li SH, Young WS, Wagster MV, Stine OC, Kidwai AS, et al. DRPLA gene (Atrophin-1) sequence and mRNA expression in human brain. Mol Brain Res 1996;36:219-226. doi:10.1016/0169-328X(95)00241-J + + + Shen Y, Peterson AS. Atrophins emerging roles in development and neurodegenerative disease. Cell Mol Life Sci 2009;66:437-446. https://doi.org/10.1007/s00018-008-8403-9 + + + Onodera O, Oyake M, Takano H, Ikeuchi T, Igarashi S, Tsuji S. Molecular cloning of a full-length cDNA for dentatorubral-pallidoluysian atrophy and regional expressions of the expanded alleles in the CNS. 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+ + + 36809550 + + 2023 + 02 + 22 + +
+ + 1527-974X + + + 2023 + Feb + 21 + + + Journal of the American Medical Informatics Association : JAMIA + J Am Med Inform Assoc + + Managing reidentification risks while providing access to the All of Us research program. + ocad021 + 10.1093/jamia/ocad021 + + The All of Us Research Program makes individual-level data available to researchers while protecting the participants' privacy. This article describes the protections embedded in the multistep access process, with a particular focus on how the data was transformed to meet generally accepted reidentification risk levels. + At the time of the study, the resource consisted of 329 084 participants. Systematic amendments were applied to the data to mitigate reidentification risk (eg, generalization of geographic regions, suppression of public events, and randomization of dates). We computed the reidentification risk for each participant using a state-of-the-art adversarial model specifically assuming that it is known that someone is a participant in the program. We confirmed the expected risk is no greater than 0.09, a threshold that is consistent with guidelines from various US state and federal agencies. We further investigated how risk varied as a function of participant demographics. + The results indicated that 95th percentile of the reidentification risk of all the participants is below current thresholds. At the same time, we observed that risk levels were higher for certain race, ethnic, and genders. + While the reidentification risk was sufficiently low, this does not imply that the system is devoid of risk. Rather, All of Us uses a multipronged data protection strategy that includes strong authentication practices, active monitoring of data misuse, and penalization mechanisms for users who violate terms of service. + © The Author(s) 2023. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For permissions, please email: journals.permissions@oup.com. + + + + Xia + Weiyi + W + 0000-0003-0406-4944 + + Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA. + + + + Basford + Melissa + M + + Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, Tennessee, USA. + + + + Carroll + Robert + R + + Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA. + + + + Clayton + Ellen Wright + EW + 0000-0002-0308-4110 + + Law School, Vanderbilt University, Nashville, Tennessee, USA. + + + Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA. + + + Department of Health Policy, Vanderbilt University Medical Center, Nashville, Tennessee, USA. + + + + Harris + Paul + P + + Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA. + + + Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, USA. + + + + Kantacioglu + Murat + M + + Department of Computer Science, University of Texas at Dallas, Dallas, Texas, USA. + + + + Liu + Yongtai + Y + + Department of Computer Science, Vanderbilt University, Nashville, Tennessee, USA. + + + + Nyemba + Steve + S + + Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA. + + + + Vorobeychik + Yevgeniy + Y + + Department of Computer Science and Engineering, Washington University in St. Louis, St. Louis, Missouri, USA. + + + + Wan + Zhiyu + Z + + Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA. + + + + Malin + Bradley A + BA + + Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA. + + + Department of Computer Science, Vanderbilt University, Nashville, Tennessee, USA. + + + Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA. + + + + eng + + + RM1HG009034 + National Institutes of Health + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + J Am Med Inform Assoc + 9430800 + 1067-5027 + + IM + + + All of Us Research Program + data privacy + data sharing + electronic health records + +
+ + + + 2022 + 10 + 04 + + + 2023 + 01 + 23 + + + 2023 + 02 + 09 + + + 2023 + 2 + 22 + 13 + 53 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809550 + 7049587 + 10.1093/jamia/ocad021 + + +
+ + + 36809556 + + 2023 + 02 + 22 + +
+ + 1437-160X + + + 2023 + Feb + 21 + + + Rheumatology international + Rheumatol Int + + Performance of cut-offs adjusted with positive control band intensity in line-blot assays for myositis-specific antibodies. + 10.1007/s00296-023-05287-5 + + The diagnostic performance of band intensity (BI) cut-offs, adjusted by a positive control band (PCB) in a line-blot assay (LBA) for myositis-related autoantibodies (MRAs) is investigated. Sera from 153 idiopathic inflammatory myositis (IIM) patients with available immunoprecipitation assay (IPA) data and 79 healthy controls were tested using the EUROLINE panel. Strips were evaluated for BI using the EUROLineScan software, and the coefficient of variation (CV) was calculated. Sensitivity and specificity, area under the curve (AUC), and the Youden's index (YI) were estimated at non-adjusted or PCB-adjusted cut-off values. Kappa statistics were calculated for IPA and LBA. Although inter-assay CV for PCB BI was 3.9%, CV was 12.9% in all samples, and a significant correlation was found between BIs of PCB and seven MRAs (all P < 0.05). At adjusted BI (aBI) > 10, the negative conversion rate of myositis-specific autoantibody (MSA)-positivity at BI > 10 was 11.5% in controls and 1.3% in patients. The specificity, AUC, and YI for MSAs at aBI > 10 or > 20 were higher than those at non-adjusted cut-off values. Additionally, AUC (0.720), YI (0.440), and the prevalence of MRAs with kappa > 0.60 (58.3%) were the highest at aBI > 20. The overall sensitivity and specificity for MSAs were 50.3% and 93.7% at aBI > 20, respectively, and 59.5% and 65.8% with BI > 10, respectively. The diagnostic performance of LBA can be improved using PCB-adjusted BIs. aBI > 20 is the optimal cut-off for IIM diagnosis using the EUROLINE LBA panel. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Chang + Sung Hae + SH + http://orcid.org/0000-0002-7980-7194 + + Department of Internal Medicine, Soonchunhyang University College of Medicine, Cheonan, 31151, South Korea. + + + + Choi + Se Rim + SR + http://orcid.org/0000-0002-4625-8571 + + Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, 82 Gumi-ro, 173 Beongil, Bundang-gu, Seongnam-si, Gyeonggi-do, 13620, South Korea. + + + + Choi + Yong Seok + YS + http://orcid.org/0000-0001-6664-0025 + + Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, 82 Gumi-ro, 173 Beongil, Bundang-gu, Seongnam-si, Gyeonggi-do, 13620, South Korea. + + + + Go + Dong Jin + DJ + http://orcid.org/0000-0001-7350-3491 + + Division of Rheumatology, Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, 07440, South Korea. + + + + Park + Jun Won + JW + http://orcid.org/0000-0002-8624-2582 + + Department of Internal Medicine, Seoul National University Hospital, Seoul, 03080, South Korea. + + + + Ha + You-Jung + YJ + http://orcid.org/0000-0001-6107-9523 + + Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, 82 Gumi-ro, 173 Beongil, Bundang-gu, Seongnam-si, Gyeonggi-do, 13620, South Korea. + + + + Park + Jin Kyun + JK + http://orcid.org/0000-0003-2167-9393 + + Department of Internal Medicine, Seoul National University Hospital, Seoul, 03080, South Korea. + + + + Kang + Eun Ha + EH + http://orcid.org/0000-0001-9697-1159 + + Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, 82 Gumi-ro, 173 Beongil, Bundang-gu, Seongnam-si, Gyeonggi-do, 13620, South Korea. + + + + Lee + Eun Young + EY + http://orcid.org/0000-0001-6975-8627 + + Department of Internal Medicine, Seoul National University Hospital, Seoul, 03080, South Korea. + + + + Shin + Kichul + K + http://orcid.org/0000-0002-6749-7598 + + Division of Rheumatology, Seoul Metropolitan Government-Seoul National University Boramae Medical Centre, Seoul, 07061, South Korea. + + + + Lee + Eun Bong + EB + http://orcid.org/0000-0003-0703-1208 + + Department of Internal Medicine, Seoul National University Hospital, Seoul, 03080, South Korea. + + + + Song + Yeong Wook + YW + http://orcid.org/0000-0002-5384-3437 + + Department of Internal Medicine, Seoul National University Hospital, Seoul, 03080, South Korea. + + + Medical Research Center, Institute of Human-Environment Interface Biology, Seoul National University, Seoul, 03080, South Korea. + + + + Lee + Yun Jong + YJ + http://orcid.org/0000-0001-7615-8611 + + Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, 82 Gumi-ro, 173 Beongil, Bundang-gu, Seongnam-si, Gyeonggi-do, 13620, South Korea. yn35@snu.ac.kr. + + + Department of Medical Device Development, Seoul National University Graduate School, Seongnam-si, Gyeonggi-do, 13605, South Korea. yn35@snu.ac.kr. + + + + eng + + + 800-20210279 + College of Medicine, Seoul National University + + + + NRF-2020M3E5E2037430 + Ministry of Science, ICT and Future Planning + + + + NRF-2022R1A2C2091831 + Ministry of Science, ICT and Future Planning + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Rheumatol Int + 8206885 + 0172-8172 + + IM + + Diagnostic performance + Idiopathic inflammatory myositis + Line blot assay + Myositis-specific autoantibody + +
+ + + + 2022 + 12 + 12 + + + 2023 + 02 + 06 + + + 2023 + 2 + 22 + 13 + 54 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809556 + 10.1007/s00296-023-05287-5 + 10.1007/s00296-023-05287-5 + + + + McHugh NJ, Tansley SL (2018) Autoantibodies in myositis. Nat Rev Rheumatol 14:290–302 + + 10.1038/nrrheum.2018.56 + 29674612 + + + + Piette Y, De Sloovere M, Vandendriessche S, Dehoorne J, De Bleecker JL, Van Praet L, Vander Mijnsbrugge AS, De Schepper S, Jacques P, De Keyser F, Smith V, Bonroy C (2020) Pitfalls in the detection of myositis specific antibodies by lineblot in clinically suspected idiopathic inflammatory myopathy. Clin Exp Rheumatol 38:212–219 + + 10.55563/clinexprheumatol/3cuc1s + 31287411 + + + + Vulsteke JB, De Langhe E, Claeys KG, Dillaerts D, Poesen K, Lenaerts J, Westhovens R, Van Damme P, Blockmans D, De Haes P, Bossuyt X (2019) Detection of myositis-specific antibodies. Ann Rheum Dis 78:e7 + + 10.1136/annrheumdis-2017-212915 + 29371203 + + + + Van Horebeek N, Vulsteke JB, Bossuyt X, Claeys KG, Dillaerts D, Poesen K, Lenaerts J, Van Damme P, Blockmans D, De Haes P, De Langhe E (2021) Detection of multiple myositis-specific autoantibodies in unique patients with idiopathic inflammatory myopathy: a single centre-experience and literature review: systematic review. Semin Arthritis Rheum 51:486–494 + + 10.1016/j.semarthrit.2021.03.012 + 33831755 + + + + Tansley SL, Snowball J, Pauling JD, Lissina A, Kuwana M, Rider LG, Rönnelid J, Mchugh NJ (2020) The promise, perceptions, and pitfalls of immunoassays for autoantibody testing in myositis. Arthritis Res Ther. https://doi.org/10.1186/s13075-020-02210-2 + + 10.1186/s13075-020-02210-2 + 32414409 + 7227250 + + + + Fiorentino DF, Gutierrez-Alamillo L, Hines D, Yang Q, Casciola-Rosen L (2019) Distinct dermatomyositis populations are detected with different autoantibody assay platforms. Clin Exp Rheumatol 37:1048–1051 + + 31376258 + 7039699 + + + + Platteel ACM, Wevers BA, Lim J, Bakker JA, Bontkes HJ, Curvers J, Damoiseaux J, Heron M, de Kort G, Limper M, van Lochem EG, Mulder AHL, Saris CGJ, van der Valk H, van der Kooi AJ, van Leeuwen EMM, Veltkamp M, Schreurs MWJ, Meek B, Hamann D (2019) Frequencies and clinical associations of myositis-related antibodies in the Netherlands: a one-year survey of all Dutch patients. J Transl Autoimmun 2:100013 + + 10.1016/j.jtauto.2019.100013 + 32743501 + 7388388 + + + + Al Nokhatha SA, Alfares E, Corcoran L, Conlon N, Conway R (2021) Association of extended myositis panel results, clinical features, and diagnoses: a single-center retrospective observational study. Rheumatol Int 41:2133–2146 + + 10.1007/s00296-021-05012-0 + 34608531 + 8550373 + + + + Mecoli CA, Albayda J, Tiniakou E, Paik JJ, Zahid U, Danoff SK, Casciola-Rosen L, Casal-Dominguez M, Pak K, Pinal-Fernandez I, Mammen AL, Christopher-Stine L (2020) Myositis Autoantibodies: a comparison of results from the Oklahoma medical research foundation myositis panel to the euroimmun research line blot. Arthritis Rheumatol 72:192–194 + + 10.1002/art.41088 + 31430029 + 6935395 + + + + Kang EH, Go DJ, Mimori T, Lee SJ, Kwon HM, Park JW, Park MH, Song EY, Ha YJ, Lee EY, Lee YJ, Lee EB, Song YW (2019) Novel susceptibility alleles in HLA region for myositis and myositis specific autoantibodies in Korean patients. Semin Arthritis Rheum 49:283–287 + + 10.1016/j.semarthrit.2019.03.005 + 30952422 + + + + Bohan A, Peter JB (1975) Polymyositis and dermatomyositis (second of two parts). N Engl J Med 292:403–407 + + 10.1056/NEJM197502202920807 + 1089199 + + + + Gerami P, Schope JM, McDonald L, Walling HW, Sontheimer RD (2006) A systematic review of adult-onset clinically amyopathic dermatomyositis (dermatomyositis siné myositis): a missing link within the spectrum of the idiopathic inflammatory myopathies. J Am Acad Dermatol 54:597–613 + + 10.1016/j.jaad.2005.10.041 + 16546580 + + + + Lundberg IE, Tjärnlund A, Bottai M, Werth VP, Pilkington C, de Visser M, Alfredsson L, Amato AA, Barohn RJ, Liang MH, Singh JA, Aggarwal R, Arnardottir S, Chinoy H, Cooper RG, Dankó K, Dimachkie MM, Feldman BM, Garcia-De La Torre I, Gordon P, Hayashi T, Katz JD, Kohsaka H, Lachenbruch PA, Lang BA, Li Y, Oddis CV, Olesinska M, Reed AM, Rutkowska-Sak L, Sanner H, Selva-O’Callaghan A, Song YW, Vencovsky J, Ytterberg SR, Miller FW, Rider LG, International Myositis Classification Criteria Project Consortium, the Euromyositis Register, and the Juvenile Dermatomyositis Cohort Biomarker Study and Repository (UK and Ireland) (2017) 2017 European league against rheumatism/American college of rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups. Arthritis Rheumatol 69:2271–2282 + + 10.1002/art.40320 + 29106061 + 5846474 + + + + Rönnelid J, Barbasso Helmers S, Storfors H, Grip K, Rönnblom L, Franck-Larsson K, Nordmark G, Lundberg IE (2009) Use of a commercial line blot assay as a screening test for autoantibodies in inflammatory myopathies. Autoimmun Rev 9:58–61 + + 10.1016/j.autrev.2009.03.005 + 19285154 + + + + Mahler M, Fritzler MJ (2019) Detection of myositis-specific antibodies: additional notes. Ann Rheum Dis 78:e45 + + 10.1136/annrheumdis-2018-213153 + 29444906 + + + + Montagnese F, Babačić H, Eichhorn P, Schoser B (2019) Evaluating the diagnostic utility of new line immunoassays for myositis antibodies in clinical practice: a retrospective study. J Neurol 266:1358–1366 + + 10.1007/s00415-019-09266-4 + 30840145 + + + + Espinosa-Ortega F, Holmqvist M, Alexanderson H, Storfors H, Mimori T, Lundberg IE, Rönnelid J (2019) Comparison of autoantibody specificities tested by a line blot assay and immunoprecipitation-based algorithm in patients with idiopathic inflammatory myopathies. Ann Rheum Dis 78:858–860 + + 10.1136/annrheumdis-2018-214690 + 30760469 + + + + Tansley SL, Li D, Betteridge ZE, McHugh NJ (2020) The reliability of immunoassays to detect autoantibodies in patients with myositis is dependent on autoantibody specificity. Rheumatology (Oxford) 59:2109–2114 + + 10.1093/rheumatology/keaa021 + 32030410 + + + + Briantais A, De Sainte MB, Campana-Salort E, Kaplanski G, Durand JM, Bertin D, Bardin N, Ebbo M, Schleinitz N (2022) Considering the level of myositis-specific autoantibodies could improve the precision of multiplex assay: lesson from patients with multiple positive results. Semin Arthritis Rheum 52:151871 + + 10.1016/j.semarthrit.2021.06.011 + 34404513 + + + + Xu A, Ye Y, Fu Q, Lian X, Chen S, Guo Q, Lu LJ, Dai M, Lv X, Bao C (2021) Prognostic values of anti-Ro52 antibodies in anti-MDA5-positive clinically amyopathic dermatomyositis associated with interstitial lung disease. Rheumatology (Oxford) 60:3343–3351 + + 10.1093/rheumatology/keaa786 + 33331866 + + + + Narayan N, Richardson CT (2022) Multiple myositis-specific autoantibodies in dermatomyositis: 2 cases and review of the literature. JAAD Case Rep 25:72–74 + + 10.1016/j.jdcr.2022.05.018 + 35769195 + 9234323 + + + + +
+ + + 36809558 + + 2023 + 02 + 22 + +
+ + 1680-0745 + + 34 + + 2023 + Feb + 13 + + + Cardiovascular journal of Africa + Cardiovasc J Afr + + Arterial stiffness assessment in obese black South African patients. + + 1-5 + + 10.5830/CVJA-2022-064 + + Increased arterial stiffness is a determinant of cardiovascular mortality and an independent marker of cardiovascular disease. The objective of this study was to asses arterial elasticity by determination of pulse-wave velocity (PWV) and augmentation index (Aix) in obese black patients. + PWV and Aix were assessed non-invasively using the AtCor SphygmoCor® system (AtCor Medical, Inc, Sydney, Australia). The study participants were divided into four groups; healthy volunteers (HV) (n = 29), patients with concomitant diseases but normal body mass index (Nd) (n = 23), obese patients without concomitant diseases (OB) (n = 29) and obese patients with concomitant diseases (OBd) ( n = 29). + The difference in the mean levels of PWV was statistically significant in the obese group with and without concomitant disease. The PWV in the OB group (7.9 ± 2.9 m/s) and in the OBd group (9.2 ± 4.4 m/s) was, respectively, 19.7 and 33.3% higher than in the HV group (6.6 ± 2.1 m/s). PWV was directly correlated with age, glycated haemoglobin level, aortic systolic blood pressure and heart rate. The risk of cardiovascular diseases in the obese patient without additional diseases was increased by 50.7%. The presence of concomitant diseases (type 2 diabetes mellitus and hypertension) in addition to obesity increased arterial stiffness by a further 11.4% and therefore also increased the risk of cardiovascular diseases by a further 35.1%. Aix was increased in the OBd and Nd groups by 8.2 and 16.5%, respectively, however the increase was not statistically significant. Aix was directly correlated with age, heart rate and aortic systolic blood pressure. + The obese black patients had a higher PWV, indicating increase in arterial stiffness and therefore a higher risk for cardiovascular disease. In addition, aging, increased blood pressure and type 2 diabetes mellitus contributed further to arterial stiffening in these obese patients. + + + + Rasakanya + T L + TL + + Department of Pharmacology and Therapeutics, Sefako Makgatho Health Science University, Pretoria, South Africa. Email: tsakani.rasakanya@smu.ac.za. + + + + Osuch + E + E + + Department of Clinical Pharmacology, School of Medicine, Dr George Mukhari Academic Hospital, Sefako Makgatho Health Sciences University, Pretoria, South Africa. + + + + eng + + Journal Article + + + 2023 + 02 + 13 + +
+ + South Africa + Cardiovasc J Afr + 101313864 + 1015-9657 + + IM + + arterial elasticity + augmentation index + blood pressure + body mass index + diabetes + pulse‐wave velocity + +
+ + + + 2021 + 08 + 12 + + + 2022 + 11 + 23 + + + 2023 + 2 + 22 + 13 + 54 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809558 + 10.5830/CVJA-2022-064 + + +
+ + + 36809559 + + 2023 + 02 + 22 + +
+ + 1445-2197 + + + 2023 + Feb + 21 + + + ANZ journal of surgery + ANZ J Surg + + Ventriculo-peritoneal shunt perforation of the small bowel. + 10.1111/ans.18345 + + + Ronan + Geoffrey + G + https://orcid.org/0000-0002-4759-1499 + + Department of Radiology, Cork University Hospital, Cork, Ireland. + + + + Dablouk + Mohammed + M + + Department of Neurosurgery, Cork University Hospital, Cork, Ireland. + + + + Waters + Peadar S + PS + https://orcid.org/0000-0003-2947-9206 + + Department of Surgery, Cork University Hospital, Cork, Ireland. + + + + Power + Stephen P + SP + + Department of Radiology, Cork University Hospital, Cork, Ireland. + + + + eng + + Case Reports + + + 2023 + 02 + 21 + +
+ + Australia + ANZ J Surg + 101086634 + 1445-1433 + + IM +
+ + + + 2022 + 12 + 14 + + + 2023 + 02 + 12 + + + 2023 + 2 + 22 + 13 + 54 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809559 + 10.1111/ans.18345 + + + References + + Case report of enterocutaneous fistula due to non-functioning ventriculoperitoneal shunt. Journal of Surgical Case Reports. Oxford Academic [Internet]. [Cited 22 Jul 2022.] Available from URL: https://academic.oup.com/jscr/article/2020/9/rjaa378/5913306 + + + Joy KA, Szewczyk BS, Adamo MA, Whyte MC. Ischemic bowel secondary to ventriculoperitoneal shunt knotting: a surprisingly rare complication of ventriculoperitoneal shunting. Case report. J. Neurosurg. Pediatr. 2020; 25: 470-5. + + + Turkis OF, Karadag A, Middlebrooks EH, Senoglu M. Anal extrusion of a ventriculoperitoneal shunt. J. Coll. Phys. Surg. Pak. JCPSP. 2019; 29: 478-80. + + + Agarwal M, Adhana R, Namdev H, Yadav YR, Agrawal T. Transoral extrusion of the ventriculo-peritoneal shunt: a case report and review of literature. J. Pediatr. Neurosci. 2011; 6: 149-51. + + + Chowdhary SK. Rare complication of intestinal volvulus with perforation of the small bowel secondary to the peritoneal end of the ventriculoperitoneal shunt (VPS). Pediatr. Surg. Int. 2001; 17: 248. + + + Bourm K, Pfeifer C, Zarchan A. Small bowel perforation: a rare complication of ventriculoperitoneal shunt placement. J. Radiol. Case Rep. 2016; 10: 30-5. + + + +
+ + + 36809564 + + 2023 + 02 + 22 + +
+ + 2691-1299 + + 3 + 2 + + 2023 + Feb + + + Current protocols + Curr Protoc + + Making Bioinformatics Training Events and Material More Discoverable Using TeSS, the ELIXIR Training Portal. + + e682 + + 10.1002/cpz1.682 + + Many trainers and organizations are passionate about sharing their training material. Sharing training material has several benefits, such as providing a record of recognition as an author, offering inspiration to other trainers, enabling researchers to discover training resources for their personal learning path, and improving the training resource landscape using data-driven gap analysis from the bioinformatics community. In this article, we present a series of protocols for using the ELIXIR online training registry Training eSupport System (TeSS). TeSS provides a one-stop shop for trainers and trainees to discover online information and content, including training materials, events, and interactive tutorials. For trainees, we provide protocols for registering and logging in and for searching and filtering content. For trainers and organizations, we also show how to manually or automatically register training events and materials. Following these protocols will contribute to promoting training events and add to a growing catalog of materials. This will concomitantly increase the FAIRness of training materials and events. Training registries like TeSS use a scraping mechanism to aggregate training resources from many providers when they have been annotated using Bioschemas specifications. Finally, we describe how to enrich training resources to allow for more efficient sharing of the structured metadata, such as prerequisites, target audience, and learning outcomes using Bioschemas specification. As increasing training events and material are aggregated in TeSS, searching the registry for specific events and materials becomes crucial. © 2023 The Authors. Current Protocols published by Wiley Periodicals LLC. Basic Protocol 1: Searching for training events and materials in TeSS Support Protocol: Integrating TeSS widgets on your website Basic Protocol 2: Logging in to TeSS using an institutional account Alternate Protocol: Creating and logging in to a TeSS account Basic Protocol 3: Manual registration of training events in TeSS Basic Protocol 4: Manual registration of training materials in TeSS Basic Protocol 5: Registration of a content provider in TeSS Basic Protocol 6: Automated harvesting of training events and materials in TeSS. + © 2023 The Authors. Current Protocols published by Wiley Periodicals LLC. + + + + Bacall + Finn + F + + Department of Computer Science, University of Manchester, Manchester, United Kingdom. + + + ELIXIR-UK, Norwich, United Kingdom. + + + + Apaolaza + Aitor + A + + Department of Computer Science, University of Manchester, Manchester, United Kingdom. + + + ELIXIR-UK, Norwich, United Kingdom. + + + + Andrabi + Munazah + M + + Department of Computer Science, University of Manchester, Manchester, United Kingdom. + + + ELIXIR-UK, Norwich, United Kingdom. + + + + Child + Chris + C + + Department of Computer Science, University of Manchester, Manchester, United Kingdom. + + + ELIXIR-UK, Norwich, United Kingdom. + + + + Goble + Carole + C + + Department of Computer Science, University of Manchester, Manchester, United Kingdom. + + + ELIXIR-UK, Norwich, United Kingdom. + + + + Sand + Olivier + O + + Institut Français de Bioinformatique, Villeneuve d'Ascq, France. + + + ELIXIR-FR, Institut Français de Bioinformatique, Évry, France. + + + + Botzki + Alexander + A + + VIB Technology Training, Vlaams Instituut voor Biotechnologie, Ghent, Belgium. + + + ELIXIR-BE, VIB, Ghent, Belgium. + + + + eng + + + ELIXIR Scientific Programme 2019-2023 + + + + + Journal Article + +
+ + United States + Curr Protoc + 101773894 + 2691-1299 + + IM + + Bioschemas annotation + TeSS + bioinformatics training + training catalog + training event + training material + +
+ + + + 2023 + 2 + 22 + 13 + 54 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809564 + 10.1002/cpz1.682 + + + Literature Cited + + + Beard, N., Bacall, F., Nenadic, A., Thurston, M., Goble, C. A., Sansone, S.-A., & Attwood, T. K. (2020). TeSS: A platform for discovering life-science training opportunities. Bioinformatics, 36(10), 3290-3291. doi: 10.1093/bioinformatics/btaa047 + + + Garcia, L., Batut, B., Burke, M. L., Kuzak, M., Psomopoulos, F., Arcila, R., … Palagi, P. M. (2020). Ten simple rules for making training materials FAIR. PLoS Computational Biology, 16(5), e1007854. doi: 10.1371/journal.pcbi.1007854 + + + Castro, L., Palagi, P. M., Beard, N., Bioschemas Training Profiles Group Members, ELIXIR FAIR Training Focus Group, The GOBLET Foundation, … Brazas, M. (2022). Bioschemas Training Profiles: A set of specifications for standardizing training information to facilitate the discovery of training programs and resources. bioRxiv, 2022.11.24.516513. doi: 10.1101/2022.11.24.516513 + + + Gray, A. J., Goble, C., & Jiménez, R. C. (2017). Bioschemas: From potato salad to protein annotation. International Semantic Web Conference; Berlin. Accessed 2019 Mar 11. Retrieved from https://pdfs.semanticscholar.org/74ec/a9c89622bff731b21b03acb4f2400a0f00fa.pdf + + + Guha, R. V., Brickley, D., & MacBeth, S. (2015). Schema.org: Evolution of structured data on the web: Big data makes common schemas even more necessary. Queue, 13(9), 10-37. doi: 10.1145/2857274.2857276 + + + Ison, J., Kalas, M., Jonassen, I., Bolser, D., Uludag, M., McWilliam, H., … Rice, P. (2013). EDAM: An ontology of bioinformatics operations, types of data and identifiers, topics and formats. Bioinformatics, 29(10), 1325-1332. doi: 10.1093/bioinformatics/btt113 + + + Jupp, S., Burdett, T., Malone, J., Leroy, C., Pearce, M., McMurry, J., & Parkinson, H. (2015). A new ontology lookup service at EMBL-EBI. In J. Malone, R. Stevens, K. Forsberg, & A. Splendiani (Eds.), Proceedings of the 8th SWAT4LS International Conference, Cambridge, UK, December 7-10, 2015. + + + Sansone, S.-A., McQuilton, P., Rocca-Serra, P., Gonzalez-Beltran, A., Izzo, M., … the FAIRsharing Community. (2019). FAIRsharing as a community approach to standards, repositories and policies. Nature Biotechnology, 37(4), 358-367. doi: 10.1038/s41587-019-0080-8 + + + Via, A., Palagi, P. M., Lindvall, J. M., Tractenberg, R. E., Attwood, T. K., & The GOBLET Foundation. (2020). Course design: Considerations for trainers - A professional guide. F1000Res, 9, 1377. doi: 10.7490/f1000research.1118395.1 + + + Whetzel, P. L., Noy, N. F., Shah, N. H., Alexander, P. R., Nyulas, C., Tudorache, T., & Musen, M. A. (2011). BioPortal: Enhanced functionality via new web services from the National Center for Biomedical Ontology to access and use ontologies in software applications. Nucleic Acids Research, 39, (suppl), W541-W545. doi: 10.1093/nar/gkr469 + + + + Internet Resources + + http://edamontology.org/ + + + https://schema.org/ + + + https://validator.schema.org + + + https://github.com/ElixirTeSS/bioschemas_sources#readme + + + https://github.com/TrainTheTrainer/ELIXIR-EXCELERATE-TtT + + + https://elixirtess.github.io/TeSS_widgets + + + + +
+ + + 36809561 + + 2023 + 02 + 22 + +
+ + 1527-974X + + + 2023 + Feb + 21 + + + Journal of the American Medical Informatics Association : JAMIA + J Am Med Inform Assoc + + Could an artificial intelligence approach to prior authorization be more human? + ocad016 + 10.1093/jamia/ocad016 + + Prior authorization (PA) may be a necessary evil within the healthcare system, contributing to physician burnout and delaying necessary care, but also allowing payers to prevent wasting resources on redundant, expensive, and/or ineffective care. PA has become an "informatics issue" with the rise of automated methods for PA review, championed in the Health Level 7 International's (HL7's) DaVinci Project. DaVinci proposes using rule-based methods to automate PA, a time-tested strategy with known limitations. This article proposes an alternative that may be more human-centric, using artificial intelligence (AI) methods for the computation of authorization decisions. We believe that by combining modern approaches for accessing and exchanging existing electronic health data with AI methods tailored to reflect the judgments of expert panels that include patient representatives, and refined with "few shot" learning approaches to prevent bias, we could create a just and efficient process that serves the interests of society as a whole. Efficient simulation of human appropriateness assessments from existing data using AI methods could eliminate burdens and bottlenecks while preserving PA's benefits as a tool to limit inappropriate care. + © The Author(s) 2023. Published by Oxford University Press on behalf of the American Medical Informatics Association. + + + + Lenert + Leslie A + LA + + Biomedical Informatics Center, Medical University of South Carolina, Charleston, South Carolina, USA. + + + + Lane + Steven + S + + Health Gorilla, Mountain View, California, USA. + + + + Wehbe + Ramsey + R + + Department of Cardiology, Medical University of South Carolina, Charleston, South Carolina, USA. + + + + eng + + + UL1 TR001450 + NH + NIH HHS + United States + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + J Am Med Inform Assoc + 9430800 + 1067-5027 + + IM + + Clinical Quality Language + appropriateness of care + artificial intelligence + prior authorization + standards + +
+ + + + 2022 + 10 + 22 + + + 2023 + 01 + 23 + + + 2023 + 02 + 02 + + + 2023 + 2 + 22 + 13 + 54 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809561 + 7049588 + 10.1093/jamia/ocad016 + + +
+ + + 36809562 + + 2023 + 02 + 22 + +
+ + 1438-2199 + + + 2023 + Feb + 21 + + + Amino acids + Amino Acids + + A new 68Ga-labeled ornithine derivative for PET imaging of ornithine metabolism in tumors. + 10.1007/s00726-023-03250-z + + Ornithine metabolism plays a vital role in tumorigenesis. For cancer cells, ornithine is mainly used as a substrate for ornithine decarboxylase (ODC) for the synthesis of polyamines. The ODC as a key enzyme of polyamine metabolism has become an important target for cancer diagnosis and treatment. To non-invasively detect the levels of ODC expression in malignant tumors, we have synthesized a novel 68Ga-labeled ornithine derivative ([68Ga]Ga-NOTA-Orn). The synthesis time of [68Ga]Ga-NOTA-Orn was about 30 min with a radiochemical yield of 45-50% (uncorrected), and the radiochemical purity was > 98%. [68Ga]Ga-NOTA-Orn was stable in saline and rat serum. Cellular uptake and competitive inhibition assays using DU145 and AR42J cells demonstrated that the transport pathway of [68Ga]Ga-NOTA-Orn was similar to that of L-ornithine, and it could interact with the ODC after transporting into the cell. Biodistribution and micro-positron emission tomography (Micro-PET) imaging studies showed that [68Ga]Ga-NOTA-Orn exhibited rapid tumor uptake and was rapidly excreted through the urinary system. All above results suggested that [68Ga]Ga-NOTA-Orn is a novel amino acid metabolic imaging agent with great potential of tumor diagnosis. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature. + + + + Wang + Hongliang + H + + Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan, 030001, Shanxi, People's Republic of China. hongliang0812@163.com. + + + Shanxi Key Laboratory of Molecular Imaging, Shanxi Medical University, Taiyuan, 030001, Shanxi, People's Republic of China. hongliang0812@163.com. + + + Collaborative Innovation Center for Molecular Imaging of Precision Medicine, Shanxi Medical University, Taiyuan, 030001, Shanxi, People's Republic of China. hongliang0812@163.com. + + + + Qin + Kaixin + K + + Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan, 030001, Shanxi, People's Republic of China. + + + + Shi + Dongmei + D + + Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan, 030001, Shanxi, People's Republic of China. + + + + Wu + Ping + P + + Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan, 030001, Shanxi, People's Republic of China. + + + Shanxi Key Laboratory of Molecular Imaging, Shanxi Medical University, Taiyuan, 030001, Shanxi, People's Republic of China. + + + Collaborative Innovation Center for Molecular Imaging of Precision Medicine, Shanxi Medical University, Taiyuan, 030001, Shanxi, People's Republic of China. + + + + Hao + Xinzhong + X + + Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan, 030001, Shanxi, People's Republic of China. + + + Shanxi Key Laboratory of Molecular Imaging, Shanxi Medical University, Taiyuan, 030001, Shanxi, People's Republic of China. + + + Collaborative Innovation Center for Molecular Imaging of Precision Medicine, Shanxi Medical University, Taiyuan, 030001, Shanxi, People's Republic of China. + + + + Liu + Haiyan + H + + Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan, 030001, Shanxi, People's Republic of China. + + + Shanxi Key Laboratory of Molecular Imaging, Shanxi Medical University, Taiyuan, 030001, Shanxi, People's Republic of China. + + + Collaborative Innovation Center for Molecular Imaging of Precision Medicine, Shanxi Medical University, Taiyuan, 030001, Shanxi, People's Republic of China. + + + + Gao + Jie + J + + National Atomic Energy Agency Nuclear Technology (Nonclinical Evaluation of Radiopharmaceuticals) Research and Development Center, China Institute for Radiation Protection, Taiyuan, 030006, Shanxi, People's Republic of China. + + + + Li + Jianguo + J + + National Atomic Energy Agency Nuclear Technology (Nonclinical Evaluation of Radiopharmaceuticals) Research and Development Center, China Institute for Radiation Protection, Taiyuan, 030006, Shanxi, People's Republic of China. + + + + Wu + Zhifang + Z + + Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan, 030001, Shanxi, People's Republic of China. + + + Shanxi Key Laboratory of Molecular Imaging, Shanxi Medical University, Taiyuan, 030001, Shanxi, People's Republic of China. + + + Collaborative Innovation Center for Molecular Imaging of Precision Medicine, Shanxi Medical University, Taiyuan, 030001, Shanxi, People's Republic of China. + + + + Li + Sijin + S + + Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan, 030001, Shanxi, People's Republic of China. lisjnm123@163.com. + + + Shanxi Key Laboratory of Molecular Imaging, Shanxi Medical University, Taiyuan, 030001, Shanxi, People's Republic of China. lisjnm123@163.com. + + + Collaborative Innovation Center for Molecular Imaging of Precision Medicine, Shanxi Medical University, Taiyuan, 030001, Shanxi, People's Republic of China. lisjnm123@163.com. + + + + eng + + + 81471695 + National Natural Science Foundation + + + + 82001873 + National Natural Science Foundation + + + + 81971655 + National Natural Science Foundation + + + + 82027804 + National Natural Science Foundation + + + + 2022XM38 + Four "Batches" Innovation Project of invigorating Medical through Science and Technology of Shanxi Province + + + + YDZJSX2022A058 + Central leading local science and Technology Development Fund Project + + + + No. CIRP-CAEA20210201 + the Open Fund Projects of China Institute for Radiation Protection Scientific Research Platform + + + + No. CIRP-CAEA20210201 + the Open Fund Projects of China Institute for Radiation Protection Scientific Research Platform + + + + No. CIRP-CAEA20210201 + the Open Fund Projects of China Institute for Radiation Protection Scientific Research Platform + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Austria + Amino Acids + 9200312 + 0939-4451 + + IM + + Molecular probes + Ornithine + PET + Polyamines + +
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+ + 1521-6551 + + + 2023 + Feb + 21 + + + IUBMB life + IUBMB Life + + 2-Deoxy-D-glucose simultaneously targets glycolysis and Wnt/β-catenin signaling to inhibit cervical cancer progression. + 10.1002/iub.2706 + + Cervical cancer is one of the most common female malignant tumors, with typical cancer metabolism characteristics of increased glycolysis flux and lactate accumulation. 2-Deoxy-D-glucose (2-DG) is a glycolysis inhibitor that acts on hexokinase, the first rate-limiting enzyme in the glycolysis pathway. In this research, we demonstrated that 2-DG effectively reduced glycolysis and impaired mitochondrial function in cervical cancer cell lines HeLa and SiHa. Cell function experiments revealed that 2-DG significantly inhibited cell growth, migration, and invasion, and induced G0/G1 phase arrest at non-cytotoxic concentrations. In addition, we found that 2-DG down-regulated Wingless-type (Wnt)/β-catenin signaling. Mechanistically, 2-DG accelerated the degradation of β-catenin protein, which resulted in the decrease of β-catenin expression in both nucleus and cytoplasm. The Wnt agonist lithium chloride and β-catenin overexpression vector could partially reverse the inhibition of malignant phenotype by 2-DG. These data suggested that 2-DG exerted its anti-cancer effects on cervical cancer by co-targeting glycolysis and Wnt/β-catenin signaling. As expected, the combination of 2-DG and Wnt inhibitor synergistically inhibited cell growth. It is noteworthy that, down-regulation of Wnt/β-catenin signaling also inhibited glycolysis, indicating a similar positive feedback regulation between glycolysis and Wnt/β-catenin signaling. In conclusion, we investigated the molecular mechanism by which 2-DG inhibits the progression of cervical cancer in vitro, elucidated the interregulation between glycolysis and Wnt/β-catenin signaling, and preliminarily explored the effect of combined targeting of glycolysis and Wnt/β-catenin signaling on cell proliferation, which provides more possibilities for the formulation of subsequent clinical treatment strategies. + © 2023 International Union of Biochemistry and Molecular Biology. + + + + Su + Min + M + https://orcid.org/0000-0002-4999-2886 + + Department of Gynecological Oncology, Zhongnan Hospital, Wuhan University, Wuhan, People's Republic of China. + + + Hubei Key Laboratory of Tumor Biological Behavior, Wuhan, People's Republic of China. + + + Hubei Clinical Cancer Study Center, Wuhan, People's Republic of China. + + + + Shan + Shidong + S + + Hubei Key Laboratory of Tumor Biological Behavior, Wuhan, People's Republic of China. + + + Department of Urology, Zhongnan Hospital, Wuhan University, Wuhan, People's Republic of China. + + + + Gao + Yang + Y + + Department of Gynecological Oncology, Zhongnan Hospital, Wuhan University, Wuhan, People's Republic of China. + + + Hubei Key Laboratory of Tumor Biological Behavior, Wuhan, People's Republic of China. + + + Hubei Clinical Cancer Study Center, Wuhan, People's Republic of China. + + + + Dai + Mengyuan + M + + Department of Gynecological Oncology, Zhongnan Hospital, Wuhan University, Wuhan, People's Republic of China. + + + Hubei Key Laboratory of Tumor Biological Behavior, Wuhan, People's Republic of China. + + + Hubei Clinical Cancer Study Center, Wuhan, People's Republic of China. + + + + Wang + Hua + H + + Department of Gynecological Oncology, Zhongnan Hospital, Wuhan University, Wuhan, People's Republic of China. + + + Hubei Key Laboratory of Tumor Biological Behavior, Wuhan, People's Republic of China. + + + Hubei Clinical Cancer Study Center, Wuhan, People's Republic of China. + + + + He + Can + C + + Department of Gynecological Oncology, Zhongnan Hospital, Wuhan University, Wuhan, People's Republic of China. + + + Hubei Key Laboratory of Tumor Biological Behavior, Wuhan, People's Republic of China. + + + Hubei Clinical Cancer Study Center, Wuhan, People's Republic of China. + + + + Zhao + Mengna + M + + Department of Gynecological Oncology, Zhongnan Hospital, Wuhan University, Wuhan, People's Republic of China. + + + Hubei Key Laboratory of Tumor Biological Behavior, Wuhan, People's Republic of China. + + + Hubei Clinical Cancer Study Center, Wuhan, People's Republic of China. + + + + Liang + Ziyan + Z + + Department of Gynecological Oncology, Zhongnan Hospital, Wuhan University, Wuhan, People's Republic of China. + + + Hubei Key Laboratory of Tumor Biological Behavior, Wuhan, People's Republic of China. + + + Hubei Clinical Cancer Study Center, Wuhan, People's Republic of China. + + + + Wan + Shimeng + S + + Department of Gynecological Oncology, Zhongnan Hospital, Wuhan University, Wuhan, People's Republic of China. + + + Hubei Key Laboratory of Tumor Biological Behavior, Wuhan, People's Republic of China. + + + Hubei Clinical Cancer Study Center, Wuhan, People's Republic of China. + + + + Yang + Junyuan + J + + Department of Gynecological Oncology, Zhongnan Hospital, Wuhan University, Wuhan, People's Republic of China. + + + Hubei Key Laboratory of Tumor Biological Behavior, Wuhan, People's Republic of China. + + + Hubei Clinical Cancer Study Center, Wuhan, People's Republic of China. + + + + Cai + Hongbing + H + + Department of Gynecological Oncology, Zhongnan Hospital, Wuhan University, Wuhan, People's Republic of China. + + + Hubei Key Laboratory of Tumor Biological Behavior, Wuhan, People's Republic of China. + + + Hubei Clinical Cancer Study Center, Wuhan, People's Republic of China. + + + + eng + + + 82002770 + National Natural Science Foundation of China Youth Project + + + + 81972447 + National Natural Science Foundation of China + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + IUBMB Life + 100888706 + 1521-6543 + + IM + + 2-Deoxy-D-glucose + Wnt/β-catenin signaling + cervical cancer + glycolysis + +
+ + + + 2022 + 10 + 28 + + + 2023 + 01 + 19 + + + 2023 + 2 + 22 + 13 + 54 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809563 + 10.1002/iub.2706 + + + REFERENCES + + Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209-249. + + + Koh WJ, Abu-Rustum NR, Bean S, et al. Cervical cancer, version 3.2019, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2019;17:64-84. + + + Cohen PA, Jhingran A, Oaknin A, Denny L. Cervical cancer. Lancet. 2019;393:169-182. + + + Hanahan D, Weinberg RA. Hallmarks of cancer: The next generation. Cell. 2011;144:646-674. + + + Faubert B, Solmonson A, DeBerardinis RJ. Metabolic reprogramming and cancer progression. Science. 2020;368(6487):eaaw5473. + + + Koppenol WH, Bounds PL, Dang CV. Otto Warburg's contributions to current concepts of cancer metabolism. 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A phase I dose-escalation trial of 2-Deoxy-D-glucose alone or combined with docetaxel in patients with advanced solid tumors. Cancer Chemother Pharmacol. 2013;71:523-530. + + + Pajak B, Siwiak-Niedbalska E, Jaskiewicz A, et al. Synergistic anticancer effect of glycolysis and histone deacetylases inhibitors in a glioblastoma model. Biomedicine. 2021;9(12):1749. + + + O'Neill S, Porter RK, McNamee N, Martinez VG, O'Driscoll L. 2-Deoxy-D-glucose inhibits aggressive triple-negative breast cancer cells by targeting glycolysis and the cancer stem cell phenotype. Sci Rep. 2019;9:3788. + + + Niehrs C. The complex world of WNT receptor signalling. Nat Rev Mol Cell Biol. 2012;13:767-779. + + + Vallee A, Lecarpentier Y, Vallee JN. The key role of the WNT/beta-catenin pathway in metabolic reprogramming in cancers under normoxic conditions. Cancers (Basel). 2021;13(21):5557. + + + Zhang W, Sviripa VM, Kril LM, et al. An underlying mechanism of dual Wnt inhibition and AMPK activation: Mitochondrial uncouplers masquerading as Wnt inhibitors. J Med Chem. 2019;62:11348-11358. + + + Yu SM, Kim HA, Kim SJ. 2-Deoxy-D-glucose regulates dedifferentiation through beta-catenin pathway in rabbit articular chondrocytes. Exp Mol Med. 2010;42:503-513. + + + Li K, Xu X, He Y, et al. P21-activated kinase 7 (PAK7) interacts with and activates Wnt/beta-catenin signaling pathway in breast cancer. J Cancer. 2018;9:1821-1835. + + + Han T, Kang D, Ji D, et al. How does cancer cell metabolism affect tumor migration and invasion? Cell Adh Migr. 2013;7:395-403. + + + Pate KT, Stringari C, Sprowl-Tanio S, et al. Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer. EMBO J. 2014;33:1454-1473. + + + Sherwood V. WNT signaling: An emerging mediator of cancer cell metabolism? Mol Cell Biol. 2015;35:2-10. + + + Rostamian H, Khakpoor-Koosheh M, Jafarzadeh L, et al. Restricting tumor lactic acid metabolism using dichloroacetate improves T cell functions. BMC Cancer. 2022;22:39. + + + Fu Y, Cai J, Xi M, et al. Neuroprotection effect of Astragaloside IV from 2-DG-induced endoplasmic reticulum stress. Oxid Med Cell Longev. 2020;2020:9782062-9782011. + + + Zhang Y, Huang F, Wang J, Luo H, Wang Z. 2-DG-regulated RIP and c-FLIP effect on liver cancer cell apoptosis induced by TRAIL. Med Sci Monit. 2015;21:3442-3448. + + + Vellano CP, Wentzensen N, Ojesina AI. Integrated genomic and molecular characterization of cervical cancer. Nature. 2017;543:378-384. + + + Yang M, Wang M, Li X, et al. Wnt signaling in cervical cancer? J Cancer. 2018;9:1277-1286. + + + Li H, Jiao S, Li X, Banu H, Hamal S, Wang X. Therapeutic effects of antibiotic drug tigecycline against cervical squamous cell carcinoma by inhibiting Wnt/beta-catenin signaling. Biochem Biophys Res Commun. 2015;467:14-20. + + + Lu W, Lin C, King TD, Chen H, Reynolds RC, Li Y. Silibinin inhibits Wnt/beta-catenin signaling by suppressing Wnt co-receptor LRP6 expression in human prostate and breast cancer cells. Cell Signal. 2012;24:2291-2296. + + + Xiao Y, Liu Q, Peng N, et al. Lovastatin inhibits RhoA to suppress canonical Wnt/beta-catenin signaling and alternative Wnt-YAP/TAZ signaling in colon cancer. Cell Transplant. 2022;31:73833691. + + + Li R, Li P, Wang J, Liu J. STIP1 down-regulation inhibits glycolysis by suppressing PKM2 and LDHA and inactivating the Wnt/beta-catenin pathway in cervical carcinoma cells. Life Sci. 2020;258:118190. + + + Lin Y, Meng F, Lu Z, et al. Knockdown of PKM2 suppresses tumor progression in human cervical cancer by modulating epithelial-mesenchymal transition via Wnt/beta-catenin signaling. Cancer Manag Res. 2018;10:4191-4202. + + + Lecarpentier Y, Schussler O, Hebert JL, Vallee A. Multiple targets of the canonical WNT/beta-catenin signaling in cancers. Front Oncol. 2019;9:1248. + + + Kleszcz R, Paluszczak J. The Wnt signaling pathway inhibitors improve the therapeutic activity of glycolysis modulators against tongue cancer cells. Int J Mol Sci. 2022;23(3):1248. + + + Voss M, Lorenz NI, Luger AL, et al. Rescue of 2-deoxyglucose side effects by ketogenic diet. Int J Mol Sci. 2018;19(8):2462. + + + Singh D, Banerji AK, Dwarakanath BS, et al. Optimizing cancer radiotherapy with 2-Deoxy-d-glucose dose escalation studies in patients with glioblastoma multiforme. Strahlenther Onkol. 2005;181:507-514. + + + Simons AL, Ahmad IM, Mattson DM, Dornfeld KJ, Spitz DR. 2-Deoxy-D-glucose combined with cisplatin enhances cytotoxicity via metabolic oxidative stress in human head and neck cancer cells. Cancer Res. 2007;67:3364-3370. + + + Pang YY, Wang T, Chen FY, et al. Glycolytic inhibitor 2-Deoxy-d-glucose suppresses cell proliferation and enhances methylprednisolone sensitivity in non-Hodgkin lymphoma cells through down-regulation of HIF-1alpha and c-MYC. Leuk Lymphoma. 2015;56:1821-1830. + + + Sandulache VC, Skinner HD, Wang Y, et al. Glycolytic inhibition alters anaplastic thyroid carcinoma tumor metabolism and improves response to conventional chemotherapy and radiation. Mol Cancer Ther. 2012;11:1373-1380. + + + Nile DL, Rae C, Walker DJ, et al. Inhibition of glycolysis and mitochondrial respiration promotes radiosensitisation of neuroblastoma and glioma cells. Cancer Metab. 2021;9:24. + + + Pattni BS, Jhaveri A, Dutta I, Baleja JD, Degterev A, Torchilin V. Targeting energy metabolism of cancer cells: Combined administration of NCL-240 and 2-DG. Int J Pharm. 2017;532:149-156. + + + Wangpaichitr M, Savaraj N, Maher J, Kurtoglu M, Lampidis TJ. Intrinsically lower AKT, mammalian target of rapamycin, and hypoxia-inducible factor activity correlates with increased sensitivity to 2-Deoxy-D-glucose under hypoxia in lung cancer cell lines. Mol Cancer Ther. 2008;7:1506-1513. + + + Sobhakumari A, Orcutt KP, Love-Homan L, et al. 2-Deoxy-d-glucose suppresses the in vivo antitumor efficacy of erlotinib in head and neck squamous cell carcinoma cells. Oncol Res. 2016;24:55-64. + + + +
+ + + 36809567 + + 2023 + 02 + 22 + +
+ + 1469-445X + + + 2023 + Feb + 21 + + + Experimental physiology + Exp Physiol + + The effect of exercise in a fasted state on plasma low-density lipoprotein cholesterol concentrations in males and females. + 10.1113/EP091005 + + Cardiovascular disease (CVD) is the leading cause of death worldwide. Physical activity interventions improve almost all modifiable CVD risk factors, but the effect of physical activity on low density lipoprotein cholesterol (LDL-C) is uncertain. This may be due to lack of research on the feeding status in which the physical activity is performed. The aim of this study is to investigate the effect of fasted versus fed exercise on LDL-C concentrations in males and females. One hundred healthy participants, equal males and females, aged between 25 and 60 years will be recruited and will undergo a home-based 12-week exercise intervention. After baseline testing, participants will be randomized to a fasted exercise (exercise after an 8-h fast) or fed exercise (exercise 90-180 min after ingestion of 1 g kg-1 CHO) group and will perform 50 min of moderate intensity exercise (e.g., 95% heart rate of lactate threshold 1) three times a week either before or after a high carbohydrate (1 g kg-1 ) meal. Participants will visit the laboratory again at week 4 and week 12 and measurements will be taken for body composition, resting blood pressure, fasting blood glucose, lipid profiles and systemic inflammation, lactate threshold, and 14-day blood glucose control. + © 2023 The Authors. Experimental Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society. + + + + Bradshaw + Louise + L + https://orcid.org/0000-0002-4201-0819 + + Centre for Nutrition, Exercise & Metabolism, Department for Health, University of Bath, Bath, UK. + + + + Koumanov + Francoise + F + + Centre for Nutrition, Exercise & Metabolism, Department for Health, University of Bath, Bath, UK. + + + + Berry + Sarah + S + + Department of Nutritional Sciences, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK. + + + + Betts + James A + JA + + Centre for Nutrition, Exercise & Metabolism, Department for Health, University of Bath, Bath, UK. + + + + Gonzalez + Javier + J + https://orcid.org/0000-0002-9939-0074 + + Centre for Nutrition, Exercise & Metabolism, Department for Health, University of Bath, Bath, UK. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Exp Physiol + 9002940 + 0958-0670 + + IM + + lipid metabolism + lipids + physical activity + +
+ + + + 2022 + 11 + 15 + + + 2023 + 02 + 03 + + + 2023 + 2 + 22 + 13 + 55 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809567 + 10.1113/EP091005 + + + REFERENCES + + Achten, J., & Jeukendrup, A. E. (2004). Relation between plasma lactate concentration and fat oxidation rates over a wide range of exercise intensities. International Journal of Sports Medicine, 25(1), 32-37. + + + Battelino, T., Danne, T., Bergenstal, R. M., Amiel, S. A., Beck, R., Biester, T., Bosi, E., Buckingham, B. A., Cefalu, W. T., Close, K. L., Cobelli, C., Dassau, E., DeVries, J. H., Donaghue, K. C., Dovc, K., Doyle, F. J., 3rd, Garg, S., Grunberger, G., Heller, S., …, Phillip, M. (2019). Clinical targets for continuous glucose monitoring data interpretation: Recommendations from the international consensus on time in range. Diabetes Care, 42(8), 1593-1603. + + + Blair, S. N., Kohl, H. W., 3rd, Barlow, C. E., Paffenbarger, R. S., Jr, Gibbons, L. W., & Macera, C. A. (1995). Changes in physical fitness and all-cause mortality: A prospective study of healthy and unhealthy men. JAMA, 273(14), 1093-1098. + + + Bland, J. M., & Altman, D. G. (2015). Best (but oft forgotten) practices: Testing for treatment effects in randomized trials by separate analyses of changes from baseline in each group is a misleading approach. The American Journal of Clinical Nutrition, 102(5), 991-994. + + + Borg, G. (1970). Perceived exertion as an indicator of somatic stress. Scandinavian Journal of Rehabilitation Medicine, 2(2), 92-98. + + + British Heart Foundation. (2020). UK factsheet. British Heart Foundation, 1-21. + + + Chrzanowski-Smith, O. J., Edinburgh, R. M., Smith, E., Thomas, M. P., Walhin, J. P., Koumanov, F., Williams, S., Betts, J. A., & Gonzalez, J. T. (2021). Resting skeletal muscle PNPLA2 (ATGL) and CPT1B are associated with peak fat oxidation rates in men and women but do not explain observed sex differences. Experimental Physiology, 106(5), 1208-1223. + + + Coyle, E. F., Jeukendrup, A. E., Oseto, M. C., Hodgkinson, B. J., & Zderic, T. W. (2001). Low-fat diet alters intramuscular substrates and reduces lipolysis and fat oxidation during exercise. American Journal of Physiology. Endocrinology and Metabolism, 280(3), E391-E398. + + + Davies, D. S. C., Atherton, F., McBride, M., & Calderwood, C. (2019). UK chief medical officers’ physical activity guidelines. Department of Health and Social Care, 1-65. https://www.gov.uk/government/publications/physical-activity-guidelines-uk-chief-medical-officers-report + + + Dela, F., Mikines, K. J., von Linstow, M., Secher, N. H., & Galbo, H. (1992). Effect of training on insulin-mediated glucose uptake in human muscle. American Journal of Physiology. Endocrinology and Metabolism, 263(6 26-6), E1134-E1143. + + + Edinburgh, R. M., Bradley, H. E., Abdullah, N. F., Robinson, S. L., Chrzanowski-Smith, O. J., Walhin, J. P., Joanisse, S., Manolopoulos, K. N., Philp, A., Hengist, A., Chabowski, A., Brodsky, F. M., Koumanov, F., Betts, J. A., Thompson, D., Wallis, G. A., & Gonzalez, J. T. (2020). Lipid metabolism links nutrient-exercise timing to insulin sensitivity in men classified as overweight or obese. The Journal of Clinical Endocrinology and Metabolism, 105(3), 660-676. + + + Enevoldsen, L. H., Simonsen, L., Macdonald, I. A., & Bülow, J. (2004). The combined effects of exercise and food intake on adipose tissue and splanchnic metabolism. The Journal of Physiology, 561(Pt 3), 871-882. + + + Fagard, R. H. (2001). Exercise characteristics and the blood pressure response to dynamic physical training. Medicine and Science in Sports and Exercise, 33(6), S484-S492. + + + Ference, B. A., Ginsberg, H. N., Graham, I., Ray, K. K., Packard, C. J., Bruckert, E., Hegele, R. A., Krauss, R. M., Raal, F. J., Schunkert, H., Watts, G. F., Borén, J., Fazio, S., Horton, J. D., Masana, L., Nicholls, S. J., Nordestgaard, B. G., van de Sluis, B., Taskinen, M. R., …, Catapano, A. L. (2017). Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European atherosclerosis society consensus panel. European Heart Journal, 38(32), 2459. + + + Frayn, K., Bernard, S., Spalding, K., & Arner, P. (2012). Adipocyte triglyceride turnover is independently associated with atherogenic dyslipidemia. Journal of the American Heart Association, 1(6), https://doi.org/10.1161/JAHA.112.003467 + + + Hardman, A. E. (1998). The influence of exercise on postprandial triacylglycerol metabolism. Atherosclerosis, 141(SUPPL. 1), S93-S100. + + + Hespanhol Junior, L. C., Pillay, J. D., van Mechelen, W., & Verhagen, E. (2015). Meta-analyses of the effects of habitual running on indices of health in physically inactive adults. Sports Medicine, 45(10), 1455-1468. + + + Horton, T. J., Commerford, S. R., Pagliassotti, M. J., & Bessesen, D. H. (2002). Postprandial leg uptake of triglyceride is greater in women than in men. American Journal of Physiology. Endocrinology and Metabolism, 283(6), E1192-E1202. + + + Jackson, R. L., Morrisett, J. D., & Gotto, A. M. (1976). Lipoprotein structure and metabolism. Physiological Reviews, 56(2), 259-316. + + + Kokkinos, F., Holland, J. C., Narayan, P., Colleran, J. A., Dotson, C. O., & Papademetriou, V. (1995). Miles run per week and high-density lipoprotein cholesterol levels in healthy, middle-aged men: A dose-response relationship. Archives of Internal Medicine, 155(4), 415-420. + + + Lundsgaard, A. M., & Kiens, B. (2014). Gender differences in skeletal muscle substrate metabolism - molecular mechanisms and insulin sensitivity. Frontiers in Endocrinology, 5(11), 195. + + + Mailing, L. J., Allen, J. M., Buford, T. W., Fields, C. J., & Woods, J. A. (2019). Exercise and the gut microbiome: A review of the evidence, potential mechanisms, and implications for human health. Exercise and Sport Sciences Reviews, 47(2), 75-85. + + + McDonough, J. R., Kusumi, F., & Bruce, R. A. (1970). Variations in maximal oxygen intake with physical activity in middle-aged men. Circulation, 41(5), 743-751. + + + Packard, C. J., Demant, T., Stewart, J. P., Bedford, D., Caslake, M. J., Schwertfeger, G., Bedynek, A., Shepherd, J., & Seidel, D. (2000). Apolipoprotein b metabolism and the distribution of VLDL and LDL subfractions. Journal of Lipid Research, 41(2), 305-317. + + + Palmisano, B. T., Zhu, L., Eckel, R. H., & Stafford, J. M. (2018). Sex differences in lipid and lipoprotein metabolism. Molecular Metabolism, 15, 45. + + + Ruge, T., Hodson, L., Cheeseman, J., Dennis, A. L., Fielding, B. A., Humphreys, S. M., Frayn, K. N., & Karpe, F. (2009). Fasted to fed trafficking of fatty acids in human adipose tissue reveals a novel regulatory step for enhanced fat storage. The Journal of Clinical Endocrinology & Metabolism, 94(5), 1781-1788. + + + Silverman, M. G., Ference, B. A., Im, K., Wiviott, S. D., Giugliano, R. P., Grundy, S. M., Braunwald, E., & Sabatine, M. S. (2016). Association between lowering LDL-C and cardiovascular risk reduction among different therapeutic interventions: A systematic review and meta-analysis. Jama, 316(12), 1289-1297. + + + Sondergaard, E., Rahbek, I., Sørensen, L. P., Christiansen, J. S., Gormsen, L. C., Jensen, M. D., & Nielsen, S. (2011). Effects of exercise on VLDL-triglyceride oxidation and turnover. American Journal of Physiology. Endocrinology and Metabolism, 300, 939-944. + + + Wewege, M. A., Thom, J. M., Rye, K. A., & Parmenter, B. J. (2018). Aerobic, resistance or combined training: A systematic review and meta-analysis of exercise to reduce cardiovascular risk in adults with metabolic syndrome. Atherosclerosis, 274, 162-171. + + + Yusuf, S., Joseph, P., Rangarajan, S., Islam, S., Mente, A., Hystad, P., Brauer, M., Kutty, V. R., Gupta, R., Wielgosz, A., AlHabib, K. F., Dans, A., Lopez-Jaramillo, P., Avezum, A., Lanas, F., Oguz, A., Kruger, I. M., Diaz, R., Yusoff, K., …, Dagenais, G. (2020). Modifiable risk factors, cardiovascular disease and mortality in 155,722 individuals from 21 high-, middle-, and low-income countries. Lancet, 395(10226), 795. + + + +
+ + + 36809560 + + 2023 + 02 + 22 + +
+ + 2366-0058 + + + 2023 + Feb + 21 + + + Abdominal radiology (New York) + Abdom Radiol (NY) + + MRI defecography revisited. At-rest pelvic floor measurements with and without rectal gel. Is there a difference? + 10.1007/s00261-023-03849-6 + + The authors sought to test if there was a difference in key pelvic floor measurements obtained during MR defecography at-rest, i.e., H-line, M-line and anorectal angle (ARA), before and after rectal gel administration. The authors also sought to determine if any observed differences would affect the interpretation of the defecography studies. + Institutional Review Board approval was obtained. An abdominal fellow retrospectively reviewed the images of all patients who underwent MRI defecography at our institution from January 2018 through June 2021. The H-line, M-line and ARA values were remeasured on T2-weighted sagittal images, with and without rectal gel for each patient. + One hundred and eleven (111) studies were included in the analysis. 18% (N = 20) of patients satisfied the criterion for pelvic floor widening before gel administration based on H-line measurement. This increased to 27% (N = 30) after rectal gel (p = 0.08). 14.4% (N = 16) met the M-line measurement criterion for pelvic floor descent before gel administration. This increased to 38.7% after rectal gel (N = 43) (p < 0.001). 67.6% (N = 75) demonstrated an abnormal ARA prior to administration of rectal gel. This decreased to 58.6% (N = 65) after rectal gel administration (p = 0.07). The overall reporting discrepancies incurred by the presence or absence of rectal gel were 16.2%, 29.7% and 23.4% for H-line, M-line and ARA, respectively. + The instillation of gel during MR defecography can cause significant changes to the observed pelvic floor measurements at-rest. This in turn can influence the interpretation of defecography studies. + © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. + + + + Dawkins + Adrian + A + + Department of Radiology, University of Kentucky, 800 Rose Street, Lexington, KY, 40536-0293, USA. Adrian.Dawkins@uky.edu. + + + + Sobieh + Ahmed + A + + Department of Radiology, University of Kentucky, 800 Rose Street, Lexington, KY, 40536-0293, USA. + + + + Myers + Charles + C + + Department of Radiology, University of Kentucky, 800 Rose Street, Lexington, KY, 40536-0293, USA. + + + + Schambach + Brian + B + + , Wheeling, USA. + + + + Nair + Rashmi + R + + Department of Radiology, University of Kentucky, 800 Rose Street, Lexington, KY, 40536-0293, USA. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Abdom Radiol (NY) + 101674571 + + IM + + Anorectal angle + Defecography + H-line + M-line + MRI + +
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+ + 1432-1351 + + + 2023 + Feb + 21 + + + Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology + J Comp Physiol A Neuroethol Sens Neural Behav Physiol + + Neurons sensitive to non-celestial polarized light in the brain of the desert locust. + 10.1007/s00359-023-01618-w + + Owing to alignment of rhodopsin in microvillar photoreceptors, insects are sensitive to the oscillation plane of polarized light. This property is used by many species to navigate with respect to the polarization pattern of light from the blue sky. In addition, the polarization angle of light reflected from shiny surfaces such as bodies of water, animal skin, leaves, or other objects can enhance contrast and visibility. Whereas photoreceptors and central mechanisms involved in celestial polarization vision have been investigated in great detail, little is known about peripheral and central mechanisms of sensing the polarization angle of light reflected from objects and surfaces. Desert locusts, like other insects, use a polarization-dependent sky compass for navigation but are also sensitive to polarization angles from horizontal directions. In order to further analyze the processing of polarized light reflected from objects or water surfaces, we tested the sensitivity of brain interneurons to the angle of polarized blue light presented from ventral direction in locusts that had their dorsal eye regions painted black. Neurons encountered interconnect the optic lobes, invade the central body, or send descending axons to the ventral nerve cord but are not part of the polarization vision pathway involved in sky-compass coding. + © 2023. The Author(s). + + + + Beck + Marius + M + + Department of Biology, Animal Physiology, Philipps University of Marburg, 35032, Marburg, Germany. + + + Institute of Biology, University of Siegen, 57068, Siegen, Germany. + + + + Althaus + Vanessa + V + + Department of Biology, Animal Physiology, Philipps University of Marburg, 35032, Marburg, Germany. + + + + Pegel + Uta + U + + Department of Biology, Animal Physiology, Philipps University of Marburg, 35032, Marburg, Germany. + + + + Homberg + Uwe + U + http://orcid.org/0000-0002-8229-7236 + + Department of Biology, Animal Physiology, Philipps University of Marburg, 35032, Marburg, Germany. homberg@biologie.uni-marburg.de. + + + Center for Mind Brain and Behavior (CMBB), Philipps-University of Marburg and Justus Liebig University of Giessen, 35032, Marburg, Germany. homberg@biologie.uni-marburg.de. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + J Comp Physiol A Neuroethol Sens Neural Behav Physiol + 101141792 + 0340-7594 + + IM + + Central complex + Desert locust + Intracellular recordings + Non-celestial polarization vision + Sky compass coding + +
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+ + + 36809565 + + 2023 + 02 + 22 + +
+ + 1478-596X + + + 2023 + Feb + 21 + + + The international journal of medical robotics + computer assisted surgery : MRCAS + Int J Med Robot + + Single-Port Laparoscopic (SPL) Versus Single-Port Robotic (SPR) Right hemicolectomy: Postoperative short-term outcomes. + + e2509 + + 10.1002/rcs.2509 + + This study aimed to compare the short-term postoperative outcomes of single-port robotic (SPR) using da Vinci SP® system and single port laparoscopic (SPL) right hemicolectomy and determine whether the novel SPR system is safe and feasible. + From January 2019 to December 2020, a total of 141 patients (41 patients for SPR and 100 patients for SPL) who electively underwent right hemicolectomy for colon cancer performed by a single surgeon were included in the study. + The time to the first bowel movement was 3 (range, 1-4) days after surgery in the SPR group and 3 (2-9, range) days in the SPL group (P = 0.017). However, there were no differences in pathologic outcomes or postoperative complications. + SPR is a safe and feasible surgical technique and has an advantage in the time to first postoperative bowel movement over SPL with no other complications. This article is protected by copyright. All rights reserved. + This article is protected by copyright. All rights reserved. + + + + Lim + Ji Ha + JH + https://orcid.org/0000-0001-9613-7965 + + Department of Surgery, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea. + + + + Yun + Seong Hyeon + SH + https://orcid.org/0000-0002-9591-4088 + + Department of Surgery, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea. + + + + Lee + Woo Yong + WY + + Department of Surgery, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea. + + + + Kim + Hee Cheol + HC + + Department of Surgery, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea. + + + + Cho + Yong Beom + YB + + Department of Surgery, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea. + + + + Huh + Jung Wook + JW + + Department of Surgery, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea. + + + + Park + Yoon Ah + YA + + Department of Surgery, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea. + + + + Shin + Jung Kyong + JK + + Department of Surgery, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Int J Med Robot + 101250764 + 1478-5951 + + IM + + bowel movement + da Vinci SP® system + operative time + single port laparoscopy + single port robot + +
+ + + + 2023 + 01 + 31 + + + 2022 + 11 + 05 + + + 2023 + 02 + 13 + + + 2023 + 2 + 22 + 13 + 54 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809565 + 10.1002/rcs.2509 + + +
+ + + 36809569 + + 2023 + 02 + 22 + +
+ + 1465-3362 + + + 2023 + Feb + 21 + + + Drug and alcohol review + Drug Alcohol Rev + + What is the hype on #MedicinalCannabis in the United States? A content analysis of medicinal cannabis tweets. + 10.1111/dar.13618 + + Medicinal cannabis is now legal in 44 US jurisdictions. Between 2020 and 2021 alone, four US jurisdictions legalised medicinal cannabis. The aim of this study is to identify themes in medicinal cannabis tweets from US jurisdictions with different legal statuses of cannabis from January to June 2021. + A total of 25,099 historical tweets from 51 US jurisdictions were collected using Python. Content analysis was performed on a random sample of tweets accounting for the population size of each US jurisdictions (n = 750). Results were presented separately by tweets posted from jurisdictions where all cannabis use (non-medicinal and medicinal) is 'fully legalised', 'illegal' and legal for 'medical-only' use. + Four themes were identified: 'Policy', 'Therapeutic value', 'Sales and industry opportunities' and 'Adverse effects'. Most of the tweets were posted by the public. The most common theme was related to 'Policy' (32.5%-61.5% of the tweets). Tweets on 'Therapeutic value' were prevalent in all jurisdictions and accounted for 23.8%-32.1% of the tweets. Sales and promotional activities were prominent even in illegal jurisdictions (12.1%-26.5% of the tweets). Fewer than 10% of tweets were about intoxication and withdrawal symptoms. + This study has explored if content themes of medicinal cannabis tweets differed by cannabis legal status. Most tweets were pro-cannabis and they were related to policy, therapeutic value, and sales and industry opportunities. Tweets on unsubstantiated health claims, adverse effects and crime warrants continued surveillance as these conversations could allow us to estimate cannabis-related harms to inform health surveillance. + © 2023 The Authors. Drug and Alcohol Review published by John Wiley & Sons Australia, Ltd on behalf of Australasian Professional Society on Alcohol and other Drugs. + + + + Lim + Carmen C W + CCW + https://orcid.org/0000-0003-1595-6307 + + National Centre for Youth Substance Use Research, The University of Queensland, Brisbane, Australia. + + + School of Psychology, The University of Queensland, Brisbane, Australia. + + + + Sun + Tianze + T + https://orcid.org/0000-0002-3939-9499 + + National Centre for Youth Substance Use Research, The University of Queensland, Brisbane, Australia. + + + School of Psychology, The University of Queensland, Brisbane, Australia. + + + + Gartner + Coral + C + https://orcid.org/0000-0002-6651-8035 + + NHMRC Centre of Research Excellence on Achieving the Tobacco Endgame, School of Public Health, The University of Queensland, Brisbane, Australia. + + + + Connor + Jason + J + https://orcid.org/0000-0002-7020-1196 + + National Centre for Youth Substance Use Research, The University of Queensland, Brisbane, Australia. + + + Discipline of Psychiatry, The University of Queensland, Brisbane, Australia. + + + + Fahmi + Marco + M + https://orcid.org/0000-0001-8479-1214 + + School of Languages and Cultures, The University of Queensland, Brisbane, Australia. + + + + Hall + Wayne + W + https://orcid.org/0000-0003-1984-0096 + + National Centre for Youth Substance Use Research, The University of Queensland, Brisbane, Australia. + + + + Hames + Sam + S + + Digital Observatory, Queensland University of Technology, Brisbane, Australia. + + + + Stjepanović + Daniel + D + https://orcid.org/0000-0003-4307-423X + + National Centre for Youth Substance Use Research, The University of Queensland, Brisbane, Australia. + + + + Chan + Gary + G + https://orcid.org/0000-0002-7569-1948 + + National Centre for Youth Substance Use Research, The University of Queensland, Brisbane, Australia. + + + + Leung + Janni + J + https://orcid.org/0000-0001-5816-2959 + + National Centre for Youth Substance Use Research, The University of Queensland, Brisbane, Australia. + + + School of Psychology, The University of Queensland, Brisbane, Australia. + + + + eng + + + APP1176137 + National Health and Medical Research Council + + + + APP2005317 + National Health and Medical Research Council + + + + APP2010008 + National Health and Medical Research Council + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Australia + Drug Alcohol Rev + 9015440 + 0959-5236 + + IM + + Twitter + United States + medicinal cannabis + medicinal marijuana + +
+ + + + 2023 + 01 + 09 + + + 2022 + 08 + 11 + + + 2023 + 01 + 16 + + + 2023 + 2 + 22 + 13 + 55 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809569 + 10.1111/dar.13618 + + + REFERENCES + + Pratt M, Stevens A, Thuku M, Butler C, Skidmore B, Wieland LS, et al. Benefits and harms of medical cannabis: a scoping review of systematic reviews. Syst Rev. 2019;8:320. + + + Price RL, Charlot KV, Frieler S, Dettori JR, Oskouian R, Chapman JR. The efficacy of cannabis in reducing back pain: a systematic review. Global Spine J. 2022;12:343-52. + + + Amini Lari M, Wang L, Neumark S, Adli T, Couban RJ, Giangregorio A, et al. Medical cannabis and cannabinoids for impaired sleep: a systematic review and meta-analysis of randomized clinical trials. Sleep. 2022;45:zsab234. + + + Black N, Stockings E, Campbell G, Tran LT, Zagic D, Hall WD, et al. Cannabinoids for the treatment of mental disorders and symptoms of mental disorders: a systematic review and meta-analysis. Lancet Psychiatry. 2019;6:995-1010. + + + Leung J, Chan G, Stjepanović D, Chung JYC, Hall W, Hammond D. Prevalence and self-reported reasons of cannabis use for medical purposes in USA and Canada. Psychopharmacology. 2022;239:1509-19. + + + Leung J, Chiu CYV, Stjepanović D, Hall W. Has the legalisation of medical and recreational cannabis use in the USA affected the prevalence of cannabis use and cannabis use disorders? Curr Addict Rep. 2018;5:403-17. + + + Sznitman SR, Bretteville-Jensen AL. Public opinion and medical cannabis policies: examining the role of underlying beliefs and national medical cannabis policies. Harm Reduct J. 2015;12:46. + + + McGinty EE, Niederdeppe J, Heley K, Barry CL. Public perceptions of arguments supporting and opposing recreational marijuana legalization. Prev Med. 2017;99:80-6. + + + Resko S, Ellis J, Early TJ, Szechy KA, Rodriguez B, Agius E. Understanding public attitudes toward cannabis legalization: qualitative findings from a statewide survey. Subst Use Misuse. 2019;54:1247-59. + + + Chiu V, Hall W, Chan G, Hides L, Leung J. A systematic review of trends in US attitudes toward cannabis legalization. Subst Use Misuse. 2022;57:1052-61. + + + Allem JP, Escobedo P, Dharmapuri L. Cannabis surveillance with Twitter data: emerging topics and social bots. Am J Public Health. 2020;110:357-62. + + + Cavazos-Rehg PA, Krauss M, Fisher SL, Salyer P, Grucza RA, Bierut LJ. Twitter chatter about marijuana. J Adolesc Health. 2015;56:139-45. + + + Daniulaityte R, Lamy FR, Smith GA, Nahhas RW, Carlson RG, Thirunarayan K, et al. “Retweet to pass the blunt”: analyzing geographic and content features of cannabis-related tweeting across the United States. J Stud Alcohol Drugs. 2017;78:910-5. + + + Daniulaityte R, Nahhas RW, Wijeratne S, Carlson RG, Lamy FR, Martins SS, et al. “Time for dabs”: analyzing Twitter data on marijuana concentrates across the U.S. Drug Alcohol Depend. 2015;155:307-11. + + + Lamy FR, Daniulaityte R, Sheth A, Nahhas RW, Martins SS, Boyer EW, et al. “Those edibles hit hard”: exploration of Twitter data on cannabis edibles in the U.S. Drug Alcohol Depend. 2016;164:64-70. + + + Lamy FR, Daniulaityte R, Zatreh M, Nahhas RW, Sheth A, Martins SS, et al. “You got to love rosin: Solventless dabs, pure, clean, natural medicine.” Exploring Twitter data on emerging trends in Rosin Tech marijuana concentrates. Drug Alcohol Depend. 2018;183:248-52. + + + Najafizada M, Rahman A, Donnan J, Dong Z, Bishop L. Analyzing sentiments and themes on cannabis in Canada using 2018 to 2020 Twitter data. J Cannabis Res. 2022;4:22. + + + van Draanen J, Tao H, Gupta S, Liu S. Geographic differences in cannabis conversations on Twitter: infodemiology study. JMIR Public Health Surveill. 2020;6:e18540. + + + Mellon Foundation. Twarc 2; 2022. + + + Hammond D, Goodman S, Wadsworth E, Rynard V, Boudreau C, Hall W. Evaluating the impacts of cannabis legalization: the International Cannabis Policy Study. Int J Drug Policy. 2020;77:102698. + + + Krauss MJ, Sowles SJ, Mylvaganam S, Zewdie K, Bierut LJ, Cavazos-Rehg PA. Displays of dabbing marijuana extracts on YouTube. Drug Alcohol Depend. 2015;155:45-51. + + + Lim CCW, Leung J, Chung JYC, Sun T, Gartner C, Connor J, et al. Content analysis of cannabis vaping videos on YouTube. Addiction. 2021;116:2443-53. + + + Munoz SR, Bangdiwala SI. Interpretation of kappa and B statistics measures of agreement. J Appl Stat. 1997;24:105-12. + + + Arnold JC. A primer on medicinal cannabis safety and potential adverse effects. Aust J Gen Pract. 2021;50:345-50. + + + Kvamme SL, Pedersen MM, Rømer Thomsen K, Thylstrup B. Exploring the use of cannabis as a substitute for prescription drugs in a convenience sample. Harm Reduct J. 2021;18:72. + + + Hammond D, Goodman S. Knowledge of tetrahydrocannabinol and cannabidiol levels among cannabis consumers in the United States and Canada. Cannabis Cannabinoid Res. 2020;7:345-54. + + + Betts KR, Aikin KJ, Kelly BJ, Johnson M, Parvanta S, Southwell BG, et al. Taking repeated exposure into account: an experimental study of direct-to-consumer prescription drug television ad effects. J Health Commun. 2019;24:503-11. + + + Trangenstein PJ. Social bots likely pose an undue influence to cannabis policy. Am J Public Health. 2020;110:264-5. + + + +
+ + + 36809568 + + 2023 + 02 + 22 + +
+ + 1468-1331 + + + 2023 + Feb + 21 + + + European journal of neurology + Eur J Neurol + + Car accidents in drivers with Parkinson's disease or Multiple Sclerosis - A Swedish nationwide study. + 10.1111/ene.15755 + + Parkinson's disease (PD) and multiple sclerosis (MS) can impair driving. However, we lack evidence of car accidents associated with these diseases. The aim was to examine what types of car accidents were associated with drivers with PD and MS, compared to individuals with ulcerative colitis (UC, the comparison group). A second aim was to evaluate the occurrence of car accident in relation to years since diagnosis. + This retrospective national wide, registry-based study included drivers involved in car accidents from 2010-2019, based on the Swedish Traffic Accident Data Acquisition database. Data on pre-existing diagnoses were retrieved retrospectively from the National Patient Registry. Data analyses included group comparisons, time-to-event analysis, and binary logistic regression. + In total, 1491 drivers, including 199 with PD, 385 with MS; and 907 with UC, were registered to have been involved in a car accident. The mean time in years, from diagnosis to the car accident were 5.6 for PD, 8.0 for MS, and 9.4 years for UC. Time to car accident since diagnose, differed significantly (p <0.001) between groups (adjusted for age). Drivers with PD had over twice the odds of a single-car accident than drivers with MS or UC, but no differences were seen between MS and UC. + Drivers with PD were older and experienced the car accidents within shorter time after the diagnosis. Although several factors may cause a car accident, fitness to drive may be more thoroughly evaluated for patients with PD by physicians, even early after the diagnosis. + This article is protected by copyright. All rights reserved. + + + + Anjemark + Linnea + L + + Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg. + + + + Selander + Helena + H + + Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg. + + + Swedish National Transport Research Institute, Gothenburg, Sweden. + + + + Persson + Hanna C + HC + https://orcid.org/0000-0001-8633-3292 + + Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg. + + + Department of Occupational Therapy and Physical Therapy, Sahlgrenska University Hospital, Gothenburg, Sweden. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Eur J Neurol + 9506311 + 1351-5101 + + IM + + Accidents, Traffic + Automobile Driving + Multiple Sclerosis + Parkinson's disease + +
+ + + + 2023 + 02 + 13 + + + 2022 + 10 + 17 + + + 2023 + 02 + 16 + + + 2023 + 2 + 22 + 13 + 55 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809568 + 10.1111/ene.15755 + + +
+ + + 36809574 + + 2023 + 02 + 22 + +
+ + 1521-4095 + + + 2023 + Feb + 21 + + + Advanced materials (Deerfield Beach, Fla.) + Adv Mater + + Materials for Cell Surface Engineering. + + e2210059 + + 10.1002/adma.202210059 + + Cell therapies are emerging as a promising new therapeutic modality in medicine, generating effective treatments of previously incurable diseases. Clinical success of cell therapies has energized the field of cellular engineering, spurring further exploration of novel approaches to improve the therapeutic performance of cell therapies. Engineering of cell surfaces using natural and synthetic materials has emerged as a valuable tool in this endeavor. This review summarizes recent advances in the development of technologies for decorating cell surfaces with various materials including nanoparticles, microparticles, and polymeric coatings, focusing on the ways in which surface decorations enhance carrier cells and therapeutic effects. Key benefits of these surface-modified cells include protecting the carrier cell, reducing particle clearance, enhancing cell trafficking, masking cell-surface antigens, modulating inflammatory phenotype of carrier cells, and delivering therapeutic agents to target tissues. While most of these technologies are still in the proof-of-concept stage, the promising therapeutic efficacy of these constructs from in vitro and in vivo preclinical studies has laid a strong foundation for further investigation for eventual clinical translation. Cell surface engineering with materials can imbue a diverse range of advantages for cell therapy, creating opportunities for innovative functionalities for improved therapeutic efficacy, and transforming the fundamental and translational landscape of cell therapies. This article is protected by copyright. All rights reserved. + This article is protected by copyright. All rights reserved. + + + + Adebowale + Kolade + K + + John A. Paulson School of Engineering and Applied Sciences, Harvard University, Allston, MA, 02134, USA. + + + Wyss Institute for Biologically Inspired Engineering, Boston, MA, 02115, USA. + + + + Liao + Rick + R + + John A. Paulson School of Engineering and Applied Sciences, Harvard University, Allston, MA, 02134, USA. + + + Wyss Institute for Biologically Inspired Engineering, Boston, MA, 02115, USA. + + + + Suja + Vineeth Chandran + VC + + John A. Paulson School of Engineering and Applied Sciences, Harvard University, Allston, MA, 02134, USA. + + + Wyss Institute for Biologically Inspired Engineering, Boston, MA, 02115, USA. + + + + Kapate + Neha + N + + John A. Paulson School of Engineering and Applied Sciences, Harvard University, Allston, MA, 02134, USA. + + + Wyss Institute for Biologically Inspired Engineering, Boston, MA, 02115, USA. + + + Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. + + + + Lu + Andrew + A + + John A. Paulson School of Engineering and Applied Sciences, Harvard University, Allston, MA, 02134, USA. + + + + Gao + Yongsheng + Y + + John A. Paulson School of Engineering and Applied Sciences, Harvard University, Allston, MA, 02134, USA. + + + Wyss Institute for Biologically Inspired Engineering, Boston, MA, 02115, USA. + + + + Mitragotri + Samir + S + https://orcid.org/0000-0002-2459-8305 + + John A. Paulson School of Engineering and Applied Sciences, Harvard University, Allston, MA, 02134, USA. + + + Wyss Institute for Biologically Inspired Engineering, Boston, MA, 02115, USA. + + + + eng + + Journal Article + Review + + + 2023 + 02 + 21 + +
+ + Germany + Adv Mater + 9885358 + 0935-9648 + + IM + + cell surface coatings + cell therapy + cellular engineering + drug delivery + microparticles + nanomedicine + +
+ + + + 2023 + 01 + 20 + + + 2022 + 10 + 31 + + + 2023 + 2 + 22 + 13 + 55 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809574 + 10.1002/adma.202210059 + + +
+ + + 36809572 + + 2023 + 02 + 22 + +
+ + 1600-0463 + + + 2023 + Feb + 21 + + + APMIS : acta pathologica, microbiologica, et immunologica Scandinavica + APMIS + + Ectopic Thyroid in EBUS: Experience from a Quality Assurance Programme. + 10.1111/apm.13303 + + A diagnostic challenge is presented: Distinguishing ectopic thyroid tissue from metastatic well differentiated follicular carcinoma in cytological material. Two cases of thyroid tissue in mediastinal lymph nodes were sampled by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). Later, the cases were presented in Labquality's non-gynaecological external quality scheme rounds in the years 2017, 2019 and 2020. The same case was presented 2 times, both in the 2017 and the 2020 rounds. The results of the three rounds and the discussion of diagnostic pitfalls of ectopic thyroid tissue are presented. A total of 112 individual laboratories worldwide participated in the external quality assurance rounds with whole-slide scanned images and digital still images of alcohol-fixed Papanicolaou-stained cytospin specimens in the years 2017, 2019 and 2020. Fifty-three laboratories participated in both the 2017 (53/70, 75.71%) and the 2020 (53/85, 62.35%) rounds. The given Pap classes between rounds were compared. Twelve (12/53, 22.6%) of the laboratories gave the same Pap class value whereas 32 (32/53, 60.4%) were in the range of ±1 class difference (Cohen's kappa -0.035, P<0.637). When comparing the diagnoses, 21 (21/53, 39.6%) laboratories gave the same diagnosis in 2017 and in 2020 (Cohen's kappa 0.039, p<0.625). Thirty-two of the laboratories gave the same diagnosis both in 2017 and 2020 (Cohen's kappa 0.004, p<0.979). Ten (10/53, 18.9%) laboratories changed their diagnose from malignant to benign, and 11 (11/53, 20.8%) changed their diagnose from benign to malignant between the 2017 and the 2020 rounds. In conclusions, the expert reference diagnosis was thyroid tissue in mediastinal lymph node. Thyroid tissue in mediastinal lymph node may be either of ectopic or neoplastic origin. The diagnostic work-up should include cytomorphological, immunohistochemical, laboratory and imaging results. If a neoplastic change is excluded, the benign category is the most feasible one. The quality assurance rounds showed a large variability in the given Pap classes. Mirroring the problematic issue both inter- and intra-laboratory of such cases both in routine diagnostics and in the classification terminologies is requiring multidisciplinary evaluation approach in the diagnostics. + This article is protected by copyright. All rights reserved. + + + + Vuorisalo + Antti + A + + Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. + + + Department of Pathology, Fimlab Laboratories, Tampere, Finland. + + + + Tommola + Erkka + E + + Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. + + + + Eloranta + Pia + P + + Labquality, Helsinki, Finland. + + + + Vanhelo + Tanja + T + + Labquality, Helsinki, Finland. + + + + Paavonen + Timo + T + + Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. + + + Department of Pathology, Fimlab Laboratories, Tampere, Finland. + + + + Kholová + Ivana + I + + Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. + + + Department of Pathology, Fimlab Laboratories, Tampere, Finland. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Denmark + APMIS + 8803400 + 0903-4641 + + IM + + Cytology + EBUS-TBNA + Ectopic Tissue + Quality Assurance + Thyroid gland + +
+ + + + 2023 + 2 + 22 + 13 + 55 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809572 + 10.1111/apm.13303 + + +
+ + + 36809578 + + 2023 + 02 + 22 + +
+ + 1445-2197 + + + 2023 + Feb + 21 + + + ANZ journal of surgery + ANZ J Surg + + Effective peer review audit and identification of the surgeon outlier. + 10.1111/ans.18343 + + Surgical audit aims to identify ways to maintain and improve the quality of care for patients, in part by assessment of a surgeon's activities and outcomes. However effective data systems to facilitate audit are uncommon. We aimed to assess the effectiveness of a tool for Peer Review Audit. + All General Surgeons in Darwin and the Top End were encouraged to self-record their surgical activity, including procedures and adverse events related to procedures, using the College's Morbidity Audit and Logbook Tool (MALT). + A total of 6 surgeons and 3518 operative events were recorded in MALT between 2018 and 2019. De-identified reports of each surgeon's activities, compared directly to the audit group, were created by each surgeon, with correction for complexity of procedures and ASA status. Nine complications Grade 3 and greater were recorded, plus 6 deaths, 25 unplanned returns to theatre (8% failure to rescue rate), 7 unplanned admissions to ICU and 8 unplanned readmissions. One surgeon outlier was identified (>3 standard deviation over group mean) for unplanned returns to theatre. This surgeon's specific cases were reviewed at our morbidity and mortality meeting using the MALT Self Audit Report and changes were implemented as a result, with future progress monitored. + The College's MALT system effectively enabled Peer Group Audit. All participating surgeons were readily able to present and validate their own results. A surgeon outlier was reliably identified. This led to effective practice change. The proportion of surgeons who participated was low. Adverse events were likely under-reported. + © 2023 Royal Australasian College of Surgeons. + + + + Treacy + P John + PJ + https://orcid.org/0000-0002-7624-0591 + + Northern Territory Medical School, Flinders University of South Australia, Adelaide, South Australia, Australia. + + + Department of Surgery, Royal Darwin Hospital, Northern Territory Department of Health, Darwin, Northern Territory, Australia. + + + + Toonson + Philip + P + + Department of Surgery, Royal Darwin Hospital, Northern Territory Department of Health, Darwin, Northern Territory, Australia. + + + + Blackadder + Helen + H + + Department of Surgery, Royal Darwin Hospital, Northern Territory Department of Health, Darwin, Northern Territory, Australia. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Australia + ANZ J Surg + 101086634 + 1445-1433 + + IM + + adverse events + audit + surgeon outlier + +
+ + + + 2023 + 01 + 31 + + + 2023 + 01 + 18 + + + 2023 + 02 + 09 + + + 2023 + 2 + 22 + 13 + 56 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809578 + 10.1111/ans.18343 + + + References + + Royal Australasian College of Surgeons. Surgical Audit Guide, 5th edn. East Melbourne: Royal Australaisan College of Surgeons; 2021 [PDF on Internet]. [Updated August 2021; Cited 1 October 2022.] Available from URL: https://www.surgeons.org/-/media/Project/RACS/surgeons-org/files/reports-guidelines-publications/manuals-guidelines/surgical-audit-and-peer-review-guide.pdf. + + + Ivers N, Jamtvedt G, Flottorp S et al. Audit and feedback: effects on professional practice and healthcare outcomes. Cochrane Database System. Rev. 2012; 6: CD000259. [Cited 01 Oct 2022.]. https://doi.org/10.1002/14651858.CD000259.pub3. + + + Bodenheimer T. The American health system: the movement for improved quality in health care. N. Engl. J. Med. 1999; 340: 488-92. + + + Antonacci AC, Lam S, Lavarias V, Homel P, Eavey RA. A report card system using error profile analysis and concurrent morbidity and mortality review: surgical outcome analysis, part II. J. Surg. Res. 2009; 153: 95-104. + + + Vogel P, Vassilev G, Kruse B, Cankaya Y. Morbidity and mortality conference as part of PDCA cycle to decrease anastomotic failure in colorectal surgery. Langenbecks Arch. Surg. 2011; 396: 1009-15. + + + Bal G, Sellier E, Tchouda SD, Francois P. Improving quality of care and patient safety through morbidity and mortality conferences. J. Healthc. Qual. 2014; 36: 29-36. + + + Calder LA, Kwok ES, Adam Cwinn A et al. Enhancing the quality of morbidity and mortality rounds: the Ottawa M&M model. Acad. Emerg. Med. 2014; 21: 314-21. + + + Steiger HJ, Stummer W, Hanggi D. Can systematic analysis of morbidity and mortality reduce complication rates in neurosurgery? Acta Neurochir. 2010; 152: 2013-9. + + + Flynn-O'Brien KT, Mandell SP, Eaton EV, Schleyer AM, McIntyre LK. Surgery and medicine residents' perspectives of morbidity and mortality conference: an interdisciplinary approach to improve ACGME Core competency compliance. J. Surg. Educ. 2015; 72: e258-66. + + + Kim MJ, Fleming FJ, Peters JH, Salloum RM, Monson JR, Eghbali ME. Improvement in educational effectiveness of morbidity and mortality conferences with structured presentation and analysis of complications. J. Surg. Educ. 2010; 67: 400-5. + + + Royal Australasian College of Surgeons. Morbidity audit and logbook tool. [Cited 1 Oct 2022.] Available from URL: https://www.surgeons.org/research-audit/morbidity-audits/morbidity-audit-and-logbook-tool. + + + Rey-Conde T, Shakya R, Allen J et al. Surgical mortality audit data validity. ANZ J. Surg. 2016; 86: 644-7. + + + Dindo D, Demartines N, Clavien P-A. Classification of surgical complications. A new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann. Surg. 2004; 240: 205-13. + + + Abraham N, Doudle M, Carson P. Open versus closed surgical treatment of abscesses: a controlled clinical trial. ANZ J. Surg. 1997; 67: 173-6. + + + Royal Australasian College of Surgeons. SNOMED CT-AU procedure list. [Cited 1 Oct 2022.] Available from URL: https://www.surgeons.org/research-audit/morbidity-audits/morbidity-audit-and-logbook-tool/accessing-using-malt/migration-to-snomed-ct-au-procedure-list. + + + Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit. Care Med. 1985; 13: 818-29. + + + Copeland GP, Jones D, Walters M. POSSUM: a scoring system for surgical audit. Br. J. Surg. 1991; 78: 355-60. + + + Baker SP, O'Neill B, Haddon W Jr, Long WB. The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care. J. 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+ + + 36809573 + + 2023 + 02 + 22 + +
+ + 1600-0625 + + + 2023 + Feb + 21 + + + Experimental dermatology + Exp Dermatol + + KRT5 mutation regulate melanin metabolism through Notch signaling pathway between keratinocytes and melanocytes. + 10.1111/exd.14761 + + Dowling-Degos disease (DDD) is an autosomal dominant hereditary skin disease characterized by acquired reticular hyperpigmentation in flexural sites, and one of its causative genes is KRT5 gene. But the effect of KRT5, expressed only in keratinocytes, on melanocytes is unclear. Other pathogenic genes of DDD include POFUT1, POGLUT1 and PSENEN genes, which is involved in posttranslational modification of Notch receptor. In this study, we aim to determine the ablation of keratinocyte KRT5 affect melanogenesis in melanocyte through Notch signaling pathway. Here we found that KRT5 downregulation decreased the expression of the Notch ligand in keratinocytes and Notch1 intracellular domain in melanocytes, by establishing two cell models of ablation of KRT5 in keratinocytes based on CRISPR/Cas9 site-directed mutation and lentivirus-mediated shRNA. Treatment of melanocytes with Notch inhibitors had same effects with ablation of KRT5 on increase of TYR and decrease of Fascin1. Activation of Notch signaling reverses the effect of ablation of KRT5 on melanogenesis. Immunohistochemistry of DDD lesions with KRT5 gene mutation confirmed changes in the expression of relevant molecules in Notch signaling. Our research elucidates molecular mechanism of KRT5-Notch signaling pathway in the regulation of melanocytes by keratinocytes, and preliminary reveal the mechanism of DDD pigment abnormality caused by KRT5 mutation. These findings identify potential therapeutic targets of the Notch signaling pathway for the treatment of skin pigment disorders. + © 2023 John Wiley & Sons Ltd. + + + + Jia + Weixue + W + + Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, 210042, Nanjing, China. + + + + Zhang + Yuanyuan + Y + + Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, 210042, Nanjing, China. + + + + Wang + Xue + X + + Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, 210042, Nanjing, China. + + + Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, 210042, Nanjing, China. + + + + Luo + Lingling + L + https://orcid.org/0000-0002-3787-6837 + + Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, 210042, Nanjing, China. + + + + Sun + Heng + H + + Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, 210042, Nanjing, China. + + + + Jiang + Yiqun + Y + + Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, 210042, Nanjing, China. + + + + Wang + Jianbo + J + + Department of Dermatology, Henan Provincial People's Hospital, Zhengzhou 450003, China. + + + + Mao + Qiuxia + Q + + Department of Dermatology, Jiangyin Hospital Affiliated to Nanjing University of Chinese Medicine, 214400, Jiangyin, China. + + + + Guo + Youming + Y + + Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, 210042, Nanjing, China. + + + + Kong + Lingzhuo + L + + Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, 210042, Nanjing, China. + + + + Mo + Ran + R + + Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, 210042, Nanjing, China. + + + + Li + Chengrang + C + + Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, 210042, Nanjing, China. + + + Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, 210042, Nanjing, China. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Denmark + Exp Dermatol + 9301549 + 0906-6705 + + IM + + Dowling-Degos disease + KRT5 + Melanin metabolism + Notch + Skin pigmentation disorder + +
+ + + + 2023 + 02 + 02 + + + 2022 + 11 + 11 + + + 2023 + 02 + 03 + + + 2023 + 2 + 22 + 13 + 55 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809573 + 10.1111/exd.14761 + + +
+ + + 36809576 + + 2023 + 02 + 22 + +
+ + 1521-3773 + + + 2023 + Feb + 21 + + + Angewandte Chemie (International ed. in English) + Angew Chem Int Ed Engl + + When It's Heavier: Interfacial and Solvation Chemistry of Isotopes in Aqueous Electrolytes for Zinc-ion Batteries. + + e202300608 + + 10.1002/anie.202300608 + + The electrochemical effect of isotope (EEI) of water is introduced in the Zn-ion batteries (ZIBs) electrolyte to deal with the challenge of severe side reactions and massive gas production. Due to the low diffusion and strong coordination of ions in D2O, the possibility of side reactions is decreased, resulting in a broader electrochemically stable potential window, less pH change, and less zinc hydroxide sulfate (ZHS) generation during cycling. Moreover, we demonstrate that D2O eliminates the different ZHS phases generated by the change of bound water during cycling because of the consistently low local ion and molecule concentration, resulting in a stable interface between the electrode and electrolyte. The full cells with D2O-based electrolyte demonstrated more stable cycling performance which displayed ~100% reversible efficiencies after 1,000 cycles with a wide voltage window of 0.8-2.0 V and 3,000 cycles with a normal voltage window of 0.8-1.9 V at a current density of 2 A g-1. + © 2023 Wiley-VCH GmbH. + + + + Gao + Xuan + X + + UCL: University College London, Chemical Engineering, UNITED KINGDOM. + + + + Dai + Yuhang + Y + + UCL: University College London, Chemistry, UNITED KINGDOM. + + + + Zhang + Chengyi + C + + Wuhan University, Institute of Technological Sciences, CHINA. + + + + Zhang + Yixuan + Y + + Technische Universität Darmstadt: Technische Universitat Darmstadt, Institute of Materials Science, GERMANY. + + + + Zong + Wei + W + + UCL: University College London, Chemistry, UNITED KINGDOM. + + + + Zhang + Wei + W + + UCL: University College London, Chemical Engineering, UNITED KINGDOM. + + + + Chen + Ruwei + R + + UCL: University College London, Chemical Engineering, UNITED KINGDOM. + + + + Zhu + Jiexin + J + + UCL: University College London, Chemical Engineering, UNITED KINGDOM. + + + + Hu + Xueying + X + + UCL: University College London, Chemistry, UNITED KINGDOM. + + + + Wang + Mingyue + M + + UCL: University College London, Chemistry, UNITED KINGDOM. + + + + Chen + Ruizhe + R + + UCL: University College London, Chemistry, UNITED KINGDOM. + + + + Du + Zijuan + Z + + UCL: University College London, Chemistry, UNITED KINGDOM. + + + + Guo + Fei + F + + UCL: University College London, Chemical Engineering, UNITED KINGDOM. + + + + Dong + Haobo + H + + UCL: University College London, Chemical Engineering, UNITED KINGDOM. + + + + Liu + Yiyang + Y + + UCL: University College London, Chemical Engineering, UNITED KINGDOM. + + + + He + Hongzhen + H + + UCL: University College London, Chemical Engineering, UNITED KINGDOM. + + + + Zhao + Siyu + S + + UCL: University College London, Chemical Engineering, UNITED KINGDOM. + + + + Zhao + Fangjia + F + + UCL: University College London, Chemistry, UNITED KINGDOM. + + + + Li + Jianwei + J + + UCL: University College London, Chemical Engineering, UNITED KINGDOM. + + + + Parkin + Ivan P + IP + + UCL: University College London, Chemistry, WC1H 0AJ, London, UNITED KINGDOM. + + + + Carmalt + Claire J + CJ + + UCL: University College London, Chemistry, UNITED KINGDOM. + + + + He + Guanjie + G + + University College London, Chemistry, Department of Chemistry - University College London - 20 Gordon Street - London, WC1H 0AJ, London, UNITED KINGDOM. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Angew Chem Int Ed Engl + 0370543 + 1433-7851 + + IM + + Isotopes + Zinc-ion batteries + interface + solvation structure + +
+ + + + 2023 + 02 + 18 + + + 2023 + 01 + 12 + + + 2023 + 02 + 21 + + + 2023 + 2 + 22 + 13 + 55 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809576 + 10.1002/anie.202300608 + + +
+ + + 36809570 + + 2023 + 02 + 22 + +
+ + 1433-7339 + + 31 + 3 + + 2023 + Feb + 21 + + + Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer + Support Care Cancer + + Leveraging GWAS data derived from a large cooperative group trial to assess the risk of taxane-induced peripheral neuropathy (TIPN) in patients being treated for breast cancer: Part 2-functional implications of a SNP cluster associated with TIPN risk in patients being treated for breast cancer. + + 178 + + 10.1007/s00520-023-07617-6 + + Using GWAS data derived from a large collaborative trial (ECOG-5103), we identified a cluster of 267 SNPs which predicted CIPN in treatment-naive patients as reported in Part 1 of this study. To assess the functional and pathological implications of this set, we identified collective gene signatures were and evaluated the informational value of those signatures in defining CIPN's pathogenesis. + In Part 1, we analyzed GWAS data derived from ECOG-5103, first identifying those SNPs that were most strongly associated with CIPN using Fisher's ratio. After identifying those SNPs which differentiated CIPN-positive from CIPN-negative phenotypes, we ranked them in order of their discriminatory power to produce a cluster of SNPs which provided the highest predictive accuracy using leave-one-out cross validation (LOOCV). An uncertainty analysis was included. Using the best predictive SNP cluster, we performed gene attribution for each SNP using NCBI Phenotype Genotype Integrator and then assessed functionality by applying GeneAnalytics, Gene Set Enrichment Analysis, and PCViz. + Using aggregate data derived from the GWAS, we identified a 267 SNP cluster which was associated with a CIPN+ phenotype with an accuracy of 96.1%. We could attribute 173 genes to the 267 SNP cluster. Six long intergenic non-protein coding genes were excluded. Ultimately, the functional analysis was based on 138 genes. Of the 17 pathways identified by Gene Analytics (GA) software, the irinotecan pharmacokinetic pathway had the highest score. Highly matching gene ontology attributions included flavone metabolic process, flavonoid glucuronidation, xenobiotic glucuronidation, nervous system development, UDP glycosyltransferase activity, retinoic acid binding, protein kinase C binding, and glucoronosyl transferase activity. Gene Set Enrichment Analysis (GSEA) GO terms identified neuron-associated genes as most significant (p = 5.45e-10). Consistent with the GA's output, flavone, and flavonoid associated terms, glucuronidation were noted as were GO terms associated with neurogenesis. + The application of functional analyses to phenotype-associated SNP clusters provides an independent validation step in assessing the clinical meaningfulness of GWAS-derived data. Functional analyses following gene attribution of a CIPN-predictive SNP cluster identified pathways, gene ontology terms, and a network which were consistent with a neuropathic phenotype. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Lustberg + Maryam + M + + Yale University, School of Medicine, New Haven, CT, USA. Maryam.Lustberg@yale.edu. + + + + Wu + Xuan + X + + Harvard School of Dental Medicine, Boston, MA, USA. + + + + Fernández-Martínez + Juan Luis + JL + + University of Oviedo, Oviedo, Spain. + + + Primary Endpoint Solutions, Waltham, MA, USA. + + + + de Andrés-Galiana + Enrique J + EJ + + University of Oviedo, Oviedo, Spain. + + + Primary Endpoint Solutions, Waltham, MA, USA. + + + + Philips + Santosh + S + + Indiana University School of Medicine, Indianapolis, Indiana, USA. + + + + Leibowitz + Jeffrey + J + + Primary Endpoint Solutions, Waltham, MA, USA. + + + Brigham and Women's Hospital, Boston, MA, USA. + + + + Schneider + Bryan + B + + Indiana University School of Medicine, Indianapolis, Indiana, USA. + + + + Sonis + Stephen + S + + Harvard School of Dental Medicine, Boston, MA, USA. + + + Primary Endpoint Solutions, Waltham, MA, USA. + + + Brigham and Women's Hospital, Boston, MA, USA. + + + Dana-Farber Cancer Institute, Boston, MA, USA. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Support Care Cancer + 9302957 + 0941-4355 + + IM + + Breast cancer + GWAS + Genomics + Peripheral neuropathy + Risk + Taxane + +
+ + + + 2022 + 08 + 16 + + + 2023 + 01 + 28 + + + 2023 + 2 + 22 + 13 + 55 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809570 + 10.1007/s00520-023-07617-6 + 10.1007/s00520-023-07617-6 + + + References + + Cavaletti G et al (2019) Chemotherapy-induced peripheral neurotoxicity: a multifaceted, still unsolved issue. J Peripher Nerv Syst 24(Suppl 2):S6–S12 + + 31647155 + + + + Autissier E (2019) Chemotherapy-induced peripheral neuropathy: association with increased risk of falls and injuries. Clin J Oncol Nurs 23(4):405–410 + + 10.1188/19.CJON.405-410 + 31322611 + + + + Shah A et al (2018) Incidence and disease burden of chemotherapy-induced peripheral neuropathy in a population-based cohort. J Neurol Neurosurg Psychiatry 89(6):636–641 + + 10.1136/jnnp-2017-317215 + 29439162 + + + + Reinbolt RE et al (2018) Genomic risk prediction of aromatase inhibitor-related arthralgia in patients with breast cancer using a novel machine-learning algorithm. Cancer Med 7(1):240–253 + + 10.1002/cam4.1256 + 29168353 + + + + Schneider BP et al (2015) Genome-wide association studies for taxane-induced peripheral neuropathy in ECOG-5103 and ECOG-1199. Clin Cancer Res 21(22):5082–5091 + + 10.1158/1078-0432.CCR-15-0586 + 26138065 + 4717479 + + + + Lustberg M et al (2023) Leveraging GWAS data derived from a large cooperative group trial to assess the risk of taxane-induced peripheral neuropathy (TIPN) in patients being treated for breast cancer Part 2. Functional implications of a SNP cluster associated with TIPN risk in patients being treated for breast cancer. Support Care in Cancer (In press) + + + Fernández-Martínez JL et al (2018) Sampling defective pathways in phenotype prediction problems via the holdout sampler. Springer International Publishing, Cham + + 10.1007/978-3-319-78759-6_3 + + + + Saligan LN et al (2014) Supervised classification by filter methods and recursive feature elimination predicts risk of radiotherapy-related fatigue in patients with prostate cancer. Cancer Inform 13:141–152 + + 10.4137/CIN.S19745 + 25506196 + 4251540 + + + + Ben-Ari Fuchs S et al (2016) GeneAnalytics: an integrative gene set analysis tool for next generation sequencing. RNAseq and Microarray Data. OMICS 20(3):139–151 + + 10.1089/omi.2015.0168 + 26983021 + + + + Ashburner M et al (2000) Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet 25(1):25–29 + + + The Gene Ontology C (2019) The gene ontology resource: 20 years and still GOing strong. Nucleic Acids Res 47(D1):D330–D338 + + 10.1093/nar/gky1055 + + + + Subramanian A et al (2005) Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci 102(43):15545–15550 + + 10.1073/pnas.0506580102 + + + + Rodchenkov I et al (2020) Pathway Commons 2019 Update: integration, analysis and exploration of pathway data. Nucleic Acids Res 48(D1):D489–D497 + + + Ransohoff JD, Wei Y, Khavari PA (2018) The functions and unique features of long intergenic non-coding RNA. Nat Rev Mol Cell Biol 19(3):143–157 + + 10.1038/nrm.2017.104 + 29138516 + + + + Seretny M et al (2014) Incidence, prevalence, and predictors ofchemotherapy-induced peripheral neuropathy: a systematic review andmeta-analysis. Pain 155(12):2461–70 + + 10.1016/j.pain.2014.09.020 + 25261162 + + + + Dolan ME et al (2017) Clinical and genome-wide analysis of cisplatin-induced peripheral neuropathy in survivors of adult-onset cancer. 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Sci Rep 8(1):8789 + + 10.1038/s41598-018-27070-4 + 29884837 + 5993794 + + + + Nadipelly J et al (2018) Effect of certain trimethoxy flavones on paclitaxel - inducedperipheral neuropathy in mice. Integr Med Res 7(2):159–167 + + 10.1016/j.imr.2018.03.006 + 29984177 + 6026363 + + + + Shahid M et al (2017) Theflavonoid 6-methoxyflavone allays cisplatin-induced neuropathicallodynia and hypoalgesia. Biomed Pharmacother 95:1725–1733 + + 10.1016/j.biopha.2017.09.108 + 28962077 + + + + Suraweera TL et al (2020) Regulation of Nrf2/ARE pathway by dietary flavonoids: a friend or foe for cancer management? Antioxidants (Basel) 9(10):973. https://doi.org/10.3390/antiox9100973 + + 10.3390/antiox9100973 + + + + Oshiro C et al (2009) Taxanepathway. Pharmacogenet Genomics 2009(19):979–83 + + 10.1097/FPC.0b013e3283335277 + + + + Yu J et al (2005) Geneexpression profiling of the irinotecan pathway in colorectal cancer. 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+ + + 36809579 + + 2023 + 02 + 22 + +
+ + 1862-3514 + + 18 + 1 + + 2023 + Feb + 21 + + + Archives of osteoporosis + Arch Osteoporos + + Fracture liaison services combined with online home nursing care in fragility hip fracture: a comparative effectiveness pilot study. + + 33 + + 10.1007/s11657-023-01221-1 + + Fracture liaison service (FLS) is a management system for osteoporotic fractures, its difficulty lies in long-term management. Through this pilot single-center study, we found that FLS combined with an internet-based follow-up service (online home nursing care) can economically and conveniently monitor patients, reduce falls and refractures, and improve care and medication adherence. + Among potential e-health platforms, mobile internet encompasses the largest user group of mobile instant messaging software in Asia and offers strong interaction, low cost, and fast speed. The online home nursing care model prevents unnecessary hospital admissions and readmissions. This study aims to explore the effects of a fracture liaison service (FLS) model combined with online home nursing care on patients with fragility hip fracture. + Patients discharged after November 2020 received FLS care combined with online home nursing care. Patients discharged from May 2020 to November 2020 received only routine discharge guidance and were classified as the control group. The Parker Mobility Score (PMS), Medical Outcomes Study 36-item short-form health survey (MOS SF-36), general medication adherence scale (GMAS), complication rate, and fall/refracture rates were used to evaluate the efficacy of the FLS combined with online home nursing care during the 52-week follow-up period. + Eighty-nine patients with complete follow-up information were included in the analysis at the 52-week follow-up. The FLS combined with online home nursing care was associated with improved osteoporosis patient care, including increased medication adherence (64.58% in the control group and 90.24% in the observation group), improved mental quality of life, reduced fall/refracture rate (12.5% and 4.88%, respectively), and reduced rates of bedsores and joint stiffness; however, there was no effect on functional recovery within 1 year. + We recommend the combination of FLS with online home nursing care, considering the local environment, to economically and conveniently monitor patients, reduce falls and refractures, and improve care and medication adherence. + © 2023. International Osteoporosis Foundation and Bone Health and Osteoporosis Foundation. + + + + Lai + Hehuan + H + + Department of Orthopedic Surgery, Affiliated Lishui Hospital of Zhejiang University, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Municipal Central Hospital, 289 Kuocang Road, Lishui, 323000, Zhejiang Province, China. + + + + Fan + Jialin + J + + Lishui Second People's Hospital, Beihuan Road 69, Liandu District, Lishui, 323000, Zhejiang Province, China. + + + + Liu + Huan + H + + Department of Orthopedic Surgery, Affiliated Lishui Hospital of Zhejiang University, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Municipal Central Hospital, 289 Kuocang Road, Lishui, 323000, Zhejiang Province, China. + + + + Wu + Xiufen + X + + Department of Orthopedic Surgery, Affiliated Lishui Hospital of Zhejiang University, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Municipal Central Hospital, 289 Kuocang Road, Lishui, 323000, Zhejiang Province, China. + + + + Wang + Lingming + L + + Department of Orthopedic Surgery, Affiliated Lishui Hospital of Zhejiang University, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Municipal Central Hospital, 289 Kuocang Road, Lishui, 323000, Zhejiang Province, China. + + + + Gao + Liumei + L + + Department of Orthopedic Surgery, Affiliated Lishui Hospital of Zhejiang University, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Municipal Central Hospital, 289 Kuocang Road, Lishui, 323000, Zhejiang Province, China. + + + + Zhou + Lili + L + + Department of Orthopedic Surgery, Affiliated Lishui Hospital of Zhejiang University, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Municipal Central Hospital, 289 Kuocang Road, Lishui, 323000, Zhejiang Province, China. + + + + Chen + Tingting + T + + Department of Orthopedic Surgery, Affiliated Lishui Hospital of Zhejiang University, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Municipal Central Hospital, 289 Kuocang Road, Lishui, 323000, Zhejiang Province, China. + + + + Zhang + Le + L + + Department of Orthopedic Surgery, Affiliated Lishui Hospital of Zhejiang University, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Municipal Central Hospital, 289 Kuocang Road, Lishui, 323000, Zhejiang Province, China. + + + + Chen + Jing + J + + Department of Orthopedic Surgery, Affiliated Lishui Hospital of Zhejiang University, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Municipal Central Hospital, 289 Kuocang Road, Lishui, 323000, Zhejiang Province, China. + + + + Luo + Zhiping + Z + http://orcid.org/0000-0003-0295-5671 + + Department of Orthopedic Surgery, Affiliated Lishui Hospital of Zhejiang University, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Municipal Central Hospital, 289 Kuocang Road, Lishui, 323000, Zhejiang Province, China. Luozhiping_56@163.com. + + + + eng + + + 2020SJZC051 + Lishui Public Welfare Technology Application Program + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Arch Osteoporos + 101318988 + + IM + + Fracture liaison service, FLS + Fragility hip fracture + General medication adherence scale, GMAS + Medical Outcomes Study 36-item short-form health survey, MOS SF-36 + Online home nursing care model + Parker Mobility Score, PMS + +
+ + + + 2022 + 10 + 10 + + + 2023 + 02 + 01 + + + 2023 + 2 + 22 + 13 + 56 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809579 + 10.1007/s11657-023-01221-1 + 10.1007/s11657-023-01221-1 + + + + Smith TO, Gilbert AW, Sreekanta A, Sahota O, Griffin XL, Cross JL, Fox C, Lamb SE (2020) Enhanced rehabilitation and care models for adults with dementia following hip fracture surgery. Cochrane Database Syst Rev 2:Cd010569 + + 32031676 + + + + Cooper C, Campion G, Melton LJ 3rd (1992) Hip fractures in the elderly: a world-wide projection. Osteoporos Int 2:285–289 + + 10.1007/BF01623184 + 1421796 + + + + Gullberg B, Johnell O, Kanis JA (1997) World-wide projections for hip fracture. Osteoporos Int 7:407–413 + + 10.1007/PL00004148 + 9425497 + + + + Johansen A, Tsang C, Boulton C, Wakeman R, Moppett I (2017) Understanding mortality rates after hip fracture repair using ASA physical status in the National Hip Fracture Database. Anaesthesia 72:961–966 + + 10.1111/anae.13908 + 28585391 + + + + Trevisan C, Bedogni M, Pavan S, Shehu E, Piazzani F, Manzato E, Sergi G, March A (2020) The impact of second hip fracture on rehospitalization and mortality in older adults. Arch Gerontol Geriatr 90:104175 + + 10.1016/j.archger.2020.104175 + 32659601 + + + + Leslie WD, Yan L, Lix LM, Morin SN (2022) Time dependency in early major osteoporotic and hip re-fractures in women and men aged 50 years and older: a population-based observational study. Osteoporos Int 33:39–46 + + 10.1007/s00198-021-06166-0 + 34562147 + + + + Osuna PM, Ruppe MD, Tabatabai LS (2017) Fracture Liaison Services: Multidisciplinary Approaches To Secondary Fracture Prevention. Endocr Pract 23:199–206 + + 10.4158/EP161433.RA + 27849385 + + + + Sanli I, van Helden SH, Ten Broeke RHM, Geusens P, Van den Bergh JPW, Brink PRG, Poeze M (2019) The role of the Fracture Liaison Service (FLS) in subsequent fracture prevention in the extreme elderly. Aging Clin Exp Res 31:1105–1111 + + 10.1007/s40520-018-1054-2 + 30311093 + + + + Nakayama A, Major G, Holliday E, Attia J, Bogduk N (2016) Evidence of effectiveness of a fracture liaison service to reduce the re-fracture rate. Osteoporos Int 27:873–879 + + 10.1007/s00198-015-3443-0 + 26650377 + + + + de Bruin IJA, Wyers CE, van den Bergh JPW, Geusens P (2017) Fracture liaison services: do they reduce fracture rates? Ther Adv Musculoskelet Dis 9:157–164 + + 10.1177/1759720X17706464 + 28717402 + 5502945 + + + + Noordin S, Allana S, Masri BA (2018) Establishing a hospital based fracture liaison service to prevent secondary insufficiency fractures. Int J Surg (London England) 54:328–332 + + 10.1016/j.ijsu.2017.09.010 + + + + Sale JE, Beaton D, Posen J, Elliot-Gibson V, Bogoch E (2011) Systematic review on interventions to improve osteoporosis investigation and treatment in fragility fracture patients. Osteoporos Int 22:2067–2082 + + 10.1007/s00198-011-1544-y + 21607808 + + + + Ganda K, Puech M, Chen JS, Speerin R, Bleasel J, Center JR, Eisman JA, March L, Seibel MJ (2013) Models of care for the secondary prevention of osteoporotic fractures: a systematic review and meta-analysis. Osteoporos Int 24:393–406 + + 10.1007/s00198-012-2090-y + 22829395 + + + + Li QP, Li J, Pan HY (2021) Effects of Online Home Nursing Care Model Application on Patients with Traumatic Spinal Cord Injury. Risk Manage Healthcare Policy 14:1703–1709 + + 10.2147/RMHP.S301874 + + + + Akesson K, Marsh D, Mitchell PJ, McLellan AR, Stenmark J, Pierroz DD, Kyer C, Cooper C (2013) Capture the fracture: a best practice framework and global campaign to break the fragility fracture cycle. Osteoporos Int 24:2135–2152 + + 10.1007/s00198-013-2348-z + 23589162 + 3706734 + + + + Javaid MK, Sami A, Lems W et al (2020) A patient-level key performance indicator set to measure the effectiveness of fracture liaison services and guide quality improvement: a position paper of the IOF Capture the Fracture Working Group, National Osteoporosis Foundation and Fragility Fracture Network. Osteoporos Int 31:1193–1204 + + 10.1007/s00198-020-05377-1 + 32266437 + 7280347 + + + + Voeten SC, Nijmeijer WS, Vermeer M, Schipper IB, Hegeman JH (2020) Validation of the Fracture Mobility Score against the Parker Mobility Score in hip fracture patients. Injury 51:395–399 + + 10.1016/j.injury.2019.10.035 + 31668574 + + + + Marsh D, Akesson K, Beaton DE, Bogoch ER, Boonen S, Brandi ML, McLellan AR, Mitchell PJ, Sale JE, Wahl DA (2011) Coordinator-based systems for secondary prevention in fragility fracture patients. Osteoporos Int 22:2051–2065 + + 10.1007/s00198-011-1642-x + 21607807 + + + + Eisman JA, Bogoch ER, Dell R, Harrington JT, McKinney RE Jr, McLellan A, Mitchell PJ, Silverman S, Singleton R, Siris E (2012) Making the first fracture the last fracture: ASBMR task force report on secondary fracture prevention. J Bone Mineral Res 27:2039–2046 + + 10.1002/jbmr.1698 + + + + Javaid MK (2021) Efficacy and efficiency of fracture liaison services to reduce the risk of recurrent osteoporotic fractures. Aging Clinical and Experimental Research 33(8)2061–2067.  https://doi.org/10.1007/s40520-021-01844-9 + + + +
+ + + 36809571 + + 2023 + 02 + 22 + +
+ + 1553-2712 + + + 2023 + Feb + 21 + + + Academic emergency medicine : official journal of the Society for Academic Emergency Medicine + Acad Emerg Med + + A Qualitative Analysis of Cancer-related Patient Care in the Emergency Department. + 10.1111/acem.14706 + + Due to an increasing incidence of new cancer diagnoses in the United States and longer survivorship, a growing number of patients with cancer receive care in emergency departments (EDs). This trend places an increasing burden on already crowded EDs, and experts are concerned these patients do not receive optimal care. The purpose of this study is to describe the experiences of ED physicians and nurses who care for patients with cancer. This information can inform strategies to improve oncology care for patients in ED settings. + We used a qualitative descriptive design to summarize to the experiences of ED physicians and nurses (n=23) caring for patients with cancer. We conducted individual, semi-structured interviews to query participants about their perspectives on care for oncology patients in the ED. + Physician and nurse participants identified 11 challenges and suggested 3 potential strategies to improve care. The challenges included the following: risk of infection, poor communication between ED staff and other providers, poor communication between oncology or primary care providers and patients, poor communication between ED providers and patients, difficult disposition decisions, new cancer diagnoses, complex pain management, allocation of limited resources, lack of cancer-specific skills among providers, poor care coordination, and evolving end-of-life decisions. The solutions included the following: patient education, education for ED providers, and improved care coordination. + Physicians and nurses experience challenges stemming from three overarching types of factors: illness factors, communication factors, and system-level factors. Solutions for the challenges of providing oncology care in the ED call for new strategies at the levels of the patient, provider, institution, and healthcare system. + This article is protected by copyright. All rights reserved. + + + + Lash + Rebecca + R + https://orcid.org/0000-0001-7946-1798 + + Children's Hospital Los Angeles, Los Angeles, CA. + + + Indiana University, School of Nursing, Fort Wayne, IN. + + + + Pettit + Nick + N + + Indiana University, Department of Emergency Medicine, Indianapolis, IN. + + + + Vachon + Eric + E + + Indiana University, School of Nursing, Regenstrief Institute, Center for Health Services Research, Indianapolis, IN. + + + + Spackman + Candice + C + + Indiana University, School of Nursing, Indianapolis, IN. + + + + Draucker + Claire Burke + CB + + Indiana University, School of Nursing, Indianapolis, IN. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Acad Emerg Med + 9418450 + 1069-6563 + + IM +
+ + + + 2023 + 02 + 02 + + + 2022 + 09 + 15 + + + 2023 + 02 + 19 + + + 2023 + 2 + 22 + 13 + 55 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809571 + 10.1111/acem.14706 + + +
+ + + 36809577 + + 2023 + 02 + 22 + +
+ + 1573-7438 + + 55 + 2 + + 2023 + Feb + 21 + + + Tropical animal health and production + Trop Anim Health Prod + + Genetic polymorphism of Β-casein gene and its association with milk production and composition in Azi-Kheli buffalo. + + 94 + + 10.1007/s11250-023-03511-9 + + The aim of this study was to find out the genetic polymorphism in β-casein gene CSN2 in Azi-Kheli buffaloes found in district Swat. Blood samples from 250 buffaloes were collected and processed in lab for sequencing to see the genetic polymorphism in CSN2 gene on 67 position of exon7. The β-casein is a milk second abundant protein having some variants, wherein A1 and A2 are the most common. After performing sequence analysis, it was found that Azi-Kheli buffaloes were homozygous for only A2 type variant. The amino acid change (proline to histadine) on 67 position of exon 7 was not found; however, three other novel SNPs at loci g.20545A > G, g.20570G > A, and g.20693C > A were identified in the study. Amino acid change due to SNPs were found as SNP1, valine > proline; SNP2, leucin > phenylalanine; and SNP3, threonine > valine. Allelic and genotypic frequencies' analysis exhibited that all three SNPs were following the Hardy-Weinberg equilibrium (HWE: P < 0.05). All the three SNPs showed medium PIC value and gene heterozygosity. The SNPs located on different position of exon 7 of CSN2 gene exhibited associations with some of the performance traits and milk composition. Higher daily milk yield of 9.86 ± 0.43 L and the peak milk yield of 13.80 ± 0.60 L were found in response to SNP3 followed by SNP2 and SNP1. The percentage of milk fat and protein was found significantly higher (P ≤ 0.05) in relation to SNP3 followed by SNP2 and SNP1 given as 7.88 ± 0.41, 7.48 ± 0.33, and 7.15 ± 0.48 for fat% and 4.00 ± 0.15, 3.73 ± 0.10 and 3.40 ± 0.10 for protein%. It was concluded that Azi-Kheli buffalo milk contains A2 genetic variant along with other useful novel variants indicating quality milk for human health. Genotypes of SNP3 should be given preference in selection both in indices and nucleotide polymorphism. + © 2023. The Author(s), under exclusive licence to Springer Nature B.V. + + + + Khan + Khalid + K + + Department of Livestock Management, Breeding and Genetics, The University of Agriculture Peshawar, Peshawar, 15130, Pakistan. + + + + Suhail + Syed Muhammad + SM + + Department of Livestock Management, Breeding and Genetics, The University of Agriculture Peshawar, Peshawar, 15130, Pakistan. + + + + Khan + Rajwali + R + http://orcid.org/0000-0001-5191-3457 + + Department of Livestock Management, Breeding and Genetics, The University of Agriculture Peshawar, Peshawar, 15130, Pakistan. rajwalikhan@aup.edu.pk. + + + + Ahmed + Ijaz + I + + Department of Livestock Management, Breeding and Genetics, The University of Agriculture Peshawar, Peshawar, 15130, Pakistan. + + + + Khan + Farhan Anwar + FA + + College of Veterinary Science, The University of Agriculture Peshawar, Peshawar, 15130, Pakistan. + + + + Khan + Muhammad Jawad + MJ + + Department of Bioinformatics, COMSAT University, Islamabad, Pakistan. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Trop Anim Health Prod + 1277355 + 0049-4747 + + IM + + Novel SNPs + Performance traits + Polymorphism + β-casein gene + +
+ + + + 2022 + 08 + 03 + + + 2023 + 02 + 11 + + + 2023 + 2 + 22 + 13 + 56 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809577 + 10.1007/s11250-023-03511-9 + 10.1007/s11250-023-03511-9 + + + + Ayaz, Suhail, S.M., Ahmad, I., Zeb, M.T., Khan, R., Ijaz, A., Ahmad, I., Riaz, M.H., Ali, F., Khan, K., and Khan, K., 2022. Detection of A2A2 genotype of beta casein protein (CSN2) gene in local, exotic and cross bred cattle in Pakistan. Animal Biotechnology, 1–12.  https://doi.org/10.1080/10495398.2022.2031204 + + + Suguna, S., Nandal, D.H., Kamble, S., Bharatha, A., & Kunkulol, R., 2014. Genomic DNA isolation from human whole blood samples by non enzymatic salting out method. Int J Pharm Pharm Sci, 6(6), 198–199 + + + Bhat, S.A., Ahmad, S.M., Ganai, N.A., Khan, S.M., Malik, A., Shah, R.A., Raashid, A. and Iqbal, Z., 2017. Association of DGAT1, beta-casein and leptin gene polymorphism with milk quality and yield traits in Jersey and its cross with local Kashmiri cattle. J. Entomol. Zool. Stud 5, 557-561. + + + Chin, D., 1999. Charaterisation of genetic variants of milk proteins that are not identified by electrophoresis (Doctoral dissertation, Ph. D thesis, Dept. of Animal Science, Montreal University, Quebec, Canada) + + + de Oliveira, L.S.M., Alves, J.S., Bastos, M.S., da Cruz, V.A.R., Pinto, L.F.B., Tonhati, H., Costa, R.B. and de Camargo, G.M.F., 2021. Water buffaloes (Bubalus bubalis) only have A2A2 genotype for beta-casein. Tropical Animal Health and Production 53, 1-4. + + 10.1007/s11250-021-02591-9 + + + + Dekkers, J.C., 2004. Commercial application of marker-and gene-assisted selection in livestock: strategies and lessons. Journal of animal science 82, E313-E328. + + 15471812 + + + + Duifhuis-Rivera, T., Lemus-Flores, C., Á Ayala-Valdovinos, M., Sánchez-Chiprés, D. R., Galindo-García, J., Mejía-Martínez, K., & González-Covarrubias, E., 2014. Polymorphisms in beta and kappa-casein are not associated with milk production in two highly technified populations of Holstein cattle in Mexico. JAPS: Journal of Animal & Plant Sciences, 24(5) + + + Khan, M.S., Ahmad, N. and Khan, M., 2007. Genetic resources and diversity in dairy buffaloes of Pakistan. Pakistan Veterinary Journal 27, 201. + + + Khan, R., Raza, S.H.A., Guo, H., Xiaoyu, W., Sen, W., Suhail, S.M., Rahman, A., Ullah, I., Abd El-Aziz, A.H. and Manzari, Z., 2020. Genetic variants in the TORC2 gene promoter and their association with body measurement and carcass quality traits in Qinchuan cattle. Plos one 15, e0227254. + + 10.1371/journal.pone.0227254 + 32059009 + 7021310 + + + + Ng-Kwai-Hang, K., Hayes, J., Moxley, J. and Monardes, H., 1986. Relationships between milk protein polymorphisms and major milk constituents in Holstein-Friesian cows. Journal of dairy science 69, 22-26. + + 10.3168/jds.S0022-0302(86)80364-2 + + + + Ng-Kwai-Hang, K. F., & Grosclaude, F., 2003. Genetic polymorphism of milk proteins. Advanced Dairy Chemistry—1 Proteins: Part A/Part B, 739-816 + + + Nowier, A.M. and Ramadan, S.I., 2020. Association of β-casein gene polymorphism with milk composition traits of Egyptian Maghrebi camels (Camelus dromedarius). Archives animal breeding 63, 493-500. + + 10.5194/aab-63-493-2020 + 33473374 + 7810228 + + + + Patel, R.K., Chauhan, J.B., Singh, K.M. and Soni, K.J., 2007. Genotype and allele frequencies of κ casein and β lac toglobulin in Indian river buffalo bulls (Bubalus bubalis). Buffalo Bull 26, 63-66. + + + Pauciullo, A., Giambra, I., Iannuzzi, L. and Erhardt, G., 2014. The β-casein in camels: molecular characterization of the CSN2 gene, promoter analysis and genetic variability. Gene 547, 159-168. + + 10.1016/j.gene.2014.06.055 + 24973699 + + + + Pineda, P.S., Santos, J.D.D. and Flores, E.B., 2019. GENETIC POLYMORPHISM OF β-CASEIN EXON 7 IN BUFFALOES (Bubalus bubalis). Philippine Journal of Veterinary and Animal Sciences 45, 197-202. + + + Ramesha, K. P., Rao, A., Basavaraju, M., Alex, R., Kataktalware, M. A., Jeyakumar, S., & Varalakshmi, S., 2016. Genetic variants of β-casein in cattle and buffalo breeding bulls in Karnataka state of India. Indian Journal of Biotechnology, 15, 178-181 + + + Raza, S.H.A., Gui, L., Khan, R., Schreurs, N.M., Xiaoyu, W., Wu, S., Mei, C., Wang, L., Ma, X. and Wei, D., 2018. Association between FASN gene polymorphisms ultrasound carcass traits and intramuscular fat in Qinchuan cattle. Gene 645, 55-59. + + 10.1016/j.gene.2017.12.034 + 29273553 + + + + Raza, S.H.A., Khan, R., Pant, S.D., Shah, M.A., Quan, G., Feng, L., Cheng, G., Gui, L.-s. and Zan, L., 2021. Genetic variation in the OPN gene affects milk composition in Chinese Holstein cows. Animal Biotechnology, 1–7. + + + Sodhi, M., Mukesh, M., Kataria, R.S., Mishra, B.P. and Joshii, B.K., 2012. Milk proteins and human health: A1/A2 milk hypothesis. Indian J Endocrinol Metab 16, 856. + + 10.4103/2230-8210.100685 + 23087884 + 3475924 + + + + Soyudal, B., Ardıçlı, S., Şamlı, H., Dinçel, D. and Balcı, F., 2019. Association of polymorphisms in the CSN2, CSN3, LGB and LALBA genes with milk production traits in Holstein cows raised in Turkey. Journal of the Hellenic Veterinary Medical Society 69(4), 1271-1282 + + 10.12681/jhvms.19617 + + + + Viale, E., Tiezzi, F., Maretto, F., De Marchi, M., Penasa, M. and Cassandro, M., 2017. Association of candidate gene polymorphisms with milk technological traits, yield, composition, and somatic cell score in Italian Holstein-Friesian sires. Journal of dairy science 100, 7271-7281. + + 10.3168/jds.2017-12666 + 28711251 + + + + Woodford, K., 2007. A2 milk, farmer decisions, and risk management. In Proceedings of the 16th International Farm Management Congress: Peer reviewed papers (pp. 641-648). England: International Farm Management Association + + + +
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+ + 1463-1318 + + + 2023 + Feb + 21 + + + Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland + Colorectal Dis + + R-TAMIS, robotic transanal minimally invasive local excision for rectal polyps. + 10.1111/codi.16533 + + + Pérez-Corbal + L + L + + University Hospital of Pontevedra. Pontevedra, Spain. + + + + Otalora + L + L + + University Hospital of Pontevedra. Pontevedra, Spain. + + + + Barreiro + E + E + + University Hospital of Pontevedra. Pontevedra, Spain. + + + + Seoane + J + J + + University Hospital of Pontevedra. Pontevedra, Spain. + + + + Ballinas + J + J + + University Hospital of Pontevedra. Pontevedra, Spain. + + + + Parajó + A + A + + University Hospital of Pontevedra. Pontevedra, Spain. + + + + eng + + Letter + + + 2023 + 02 + 21 + +
+ + England + Colorectal Dis + 100883611 + 1462-8910 + + IM +
+ + + + 2023 + 02 + 01 + + + 2022 + 12 + 22 + + + 2023 + 02 + 05 + + + 2023 + 2 + 22 + 13 + 56 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809580 + 10.1111/codi.16533 + + +
+ + + 36809585 + + 2023 + 02 + 22 + +
+ + 1436-6215 + + + 2023 + Feb + 21 + + + European journal of nutrition + Eur J Nutr + + Correction to: 18β‑Glycyrrhetinic acid altered the intestinal permeability in the human Caco‑2 monolayer cell model. + 10.1007/s00394-023-03114-y + + + Malekinejad + Mojtaba + M + + Experimental and Applied Pharmaceutical Sciences Research Center, Urmia University of Medical Sciences, Urmia, Iran. + + + Department of Internal Medicine, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran. + + + + Pashaei + Mohammad Reza + MR + + Department of Internal Medicine, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran. pashaee.m@umsu.ac.ir. + + + + Malekinejad + Hassan + H + + Experimental and Applied Pharmaceutical Sciences Research Center, Urmia University of Medical Sciences, Urmia, Iran. hassanmalekinejad@yahoo.com. + + + Department of Pharmacology and Toxicology, School of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran. hassanmalekinejad@yahoo.com. + + + + eng + + Published Erratum + + + 2023 + 02 + 21 + +
+ + Germany + Eur J Nutr + 100888704 + 1436-6207 + + IM + + + Eur J Nutr. 2022 Oct;61(7):3437-3447 + 35578042 + + +
+ + + + 2023 + 2 + 22 + 13 + 56 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809585 + 10.1007/s00394-023-03114-y + 10.1007/s00394-023-03114-y + + +
+ + + 36809581 + + 2023 + 02 + 22 + +
+ + 1478-3231 + + + 2023 + Feb + 21 + + + Liver international : official journal of the International Association for the Study of the Liver + Liver Int + + Susceptibility to Hepatitis B Virus Infection in Adults Living in Spain. + 10.1111/liv.15548 + + A protective hepatitis B virus (HBV) vaccine has been available for four decades. Universal HBV vaccination of infants is recommended by the WHO since the 90s. Furthermore, HBV immunization is advised to all adults with high-risk behaviors and no seroprotection. However, HBV vaccine coverage remains globally suboptimal. The advent of new more efficacious trivalent HBV vaccines has renewed the interest for HBV vaccination. At this time, the extent of current HBV susceptibility in adults remains unknown in Spain. + HBV serological markers were assessed on a large and representative sample of adults in Spain, including blood donors and individuals belonging to high-risk groups. Serum HBsAg, anti-HBc and anti-HBs were tested in specimens collected during the last couple of years. + From 13,859 consecutive adults tested at 7 cities across the Spanish geography, overall 166 (1.2%) had positive HBsAg. Past HBV infection was recognized in 14% and prior vaccine immunization in 24%. Unexpectedly, 37% of blood donors and 63% of persons belonging to high-risk groups had no serum HBV markers and therefore were potentially HBV susceptible. + Roughly 60% of adults living in Spain seem to be HBV susceptible. Waning immunity might be more common than expected. Hence, HBV serological testing should be performed at least once in all adults regardless risk exposures. HBV vaccine full courses or boosters should be administered to all adults lacking serological evidence of HBV protection. + This article is protected by copyright. All rights reserved. + + + + Soriano + Vicente + V + https://orcid.org/0000-0002-4624-5199 + + Universidad Internacional de La Rioja (UNIR), Madrid. + + + + Aguilera + Antonio + A + + Hospital Clínico Universitario de Santiago & GI-1209 USC, Santiago de Compostela. + + + + Benito + Rafael + R + + Hospital Universitario Lozano Blesa & Universidad de Zaragoza, Zaragoza. + + + + González-Díez + Rocío + R + + Centro de Transfusión de la Comunidad de Madrid, Madrid. + + + + Miró + Elisenda + E + + Hospital de Sant Pau, Barcelona. + + + + Liendo + Paloma + P + + Hospital General de Basurto, Bilbao. + + + + Rodríguez-Diaz + Juan Carlos + JC + + Hospital General Universitario Dr. Balmis, Alicante. + + + + Cabezas + Teresa + T + + Hospital de Torrecárdenas, Almería. + + + + Richart + Alberto + A + + Centro de Transfusión de la Comunidad de Madrid, Madrid. + + + + Ramos + José Manuel + JM + + Hospital General Universitario Dr. Balmis, Alicante. + + + + Barea + Luisa + L + + Centro de Transfusión de la Comunidad de Madrid, Madrid. + + + + Álvarez + Carmen + C + + Universidad Internacional de La Rioja (UNIR), Madrid. + + + + Treviño + Ana + A + + Universidad Internacional de La Rioja (UNIR), Madrid. + + + + Gómez-Gallego + Félix + F + + Universidad Internacional de La Rioja (UNIR), Madrid. + + + + Corral + Octavio + O + + Universidad Internacional de La Rioja (UNIR), Madrid. + + + + de Mendoza + Carmen + C + + Puerta de Hierro University Hospital & Research Institute, Majadahonda, Spain. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Liver Int + 101160857 + 1478-3223 + + IM + + antibody waning + diagnosis + hepatitis B + prevention + public health + vaccine + +
+ + + + 2023 + 01 + 11 + + + 2022 + 10 + 01 + + + 2023 + 02 + 20 + + + 2023 + 2 + 22 + 13 + 56 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809581 + 10.1111/liv.15548 + + +
+ + + 36809575 + + 2023 + 02 + 22 + +
+ + 1433-7339 + + 31 + 3 + + 2023 + Feb + 21 + + + Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer + Support Care Cancer + + Multinational Association of Supportive Care in Cancer (MASCC) guidelines: cannabis for psychological symptoms including insomnia, anxiety, and depression. + + 176 + + 10.1007/s00520-023-07628-3 + + During the treatment of cancer, 18% of patients use cannabis for symptom management. Anxiety, depression, and sleep disturbances are common symptoms in cancer. A systematic review of the evidence for cannabis use for psychological symptoms in cancer patients was undertaken to develop a guideline. + A literature search of randomized trials and systematic reviews was undertaken up to November 12, 2021. Studies were independently assessed for evidence by two authors and then evaluated by all authors for approval. The literature search involved MEDLINE, CCTR, EMBASE, and PsychINFO databases. Inclusion criteria included randomized control trials and systematic reviews on cannabis versus placebo or active comparator in patients with cancer and psychological symptom management (anxiety, depression, and insomnia). + The search yielded 829 articles; 145 from Medline, 419 from Embase, 62 from PsychINFO, and 203 from CCTR. Two systematic reviews and 15 randomized trials (4 on sleep, 5 on mood, 6 on both) met eligibility criteria. However, no studies specifically assessed the efficacy of cannabis on psychological symptoms as primary outcomes in cancer patients. The studies varied widely in terms of interventions, control, duration, and outcome measures. Six of 15 RCTs suggested benefits (five for sleep, one for mood). + There is no high-quality evidence to recommend the use of cannabis as an intervention for psychological symptoms in patients with cancer until more high-quality research demonstrates benefit. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + De Feo + Giulia + G + + Department of Medical Oncology and Haematology, Oncology-Supportive Care Unit, Fondazione IRCCS, Istituto Nazionale Tumori Di Milano, Milan, Italy. + + + + Case + Amy A + AA + + Division of Geriatrics and Palliative Medicine, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. + + + + Crawford + Gregory B + GB + + South Australia, Faculty of Health and Medical Sciences, Northern Adelaide Local Health Network, University of Adelaide, Adelaide, Australia. + + + + Hui + David + D + + Department of Palliative Care, Rehabilitation and Integrative Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA. + + + + To + Josephine + J + + Division of Aged Care, Rehabilitation and Palliative Care, Northern Adelaide Local Health Network, Adelaide, Australia. + + + + Sbrana + Andrea + A + + University of Pisa, Pisa, Italy. + + + + Alderman + Bryony + B + + Frimley Park Hospital, Frimley, UK. + + + + Mukhopadhyay + Sandip + S + + Department of Pharmacology, Burdwan Medical College, Burdwan, India. + + + + Bouleuc + Carole + C + + Department of Supportive and Palliative Care, PSL University, Institut Curie, Paris, France. + + + + Amano + Koji + K + + Department of Palliative Medicine, National Cancer Center Hospital, Tokyo, Japan. + + + + Tanco + Kimberson + K + + Department of Palliative Care, Rehabilitation and Integrative Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA. + + + + Garsed + Jessica + J + + Clinical Informationist, Geisinger Medical Center, Danville, USA. + + + + Davis + Mellar + M + + Palliative Care Department, Geisinger Medical System, Danville, USA. mdavis2@geisinger.edu. + + + + eng + + Journal Article + Review + + + 2023 + 02 + 21 + +
+ + Germany + Support Care Cancer + 9302957 + 0941-4355 + + IM + + Anxiety + CCTR + Cannabis + Depression + EMBASE + Insomnia + MASCC + MEDLINE + PsychINFO databases + +
+ + + + 2022 + 10 + 13 + + + 2023 + 02 + 02 + + + 2023 + 2 + 22 + 13 + 55 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809575 + 10.1007/s00520-023-07628-3 + 10.1007/s00520-023-07628-3 + + + + Martell K, Fairchild A, LeGerrier B et al (2018) Rates of cannabis use in patients with cancer. Curr Oncol 25:219–225 + + 29962840 + 6023560 + 10.3747/co.25.3983 + + + + Kaul M, Zee PC, Sahni SA (2021) Effects of cannabinoids on sleep and their therapeutic potential for sleep disorders. Neurotherapeutics 18:217–227 + + 33580483 + 8116407 + 10.1007/s13311-021-01013-w + + + + Daris B, Verboten MT, Knez Z et al (2019) Cannabinoids in cancer treatment: therapeutic potential and legislation. Bosn J Basic Med Sci 19:14–23 + + 30172249 + 6387667 + 10.17305/bjbms.2018.3532 + + + + Pawasarat IM, Schultz EM, Firsby JC et al (2020) The efficacy of medical marijuana in the treatment of cancer-related pain. 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+ + + 36809589 + + 2023 + 02 + 22 + +
+ + 1708-0428 + + + 2023 + Feb + 21 + + + Obesity surgery + Obes Surg + + Reply to Letter to the Editor: Beyond the BMI: a Critical Analysis of the Edmonton Obesity Staging System and the New Guidelines for Indications for Metabolic and Bariatric Surgery. + 10.1007/s11695-023-06517-2 + + + Eisenberg + Dan + D + http://orcid.org/0000-0002-5908-3942 + + Department of Surgery, Stanford School of Medicine and VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, CA, 112, USA. daneisenberg@stanford.edu. + + + + Shikora + Scott A + SA + + Department of Surgery, Center for Metabolic and Bariatric Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. + + + + Kothari + Shanu N + SN + + Prisma Health, Department of Surgery, University of South Carolina School of Medicine, Greenville, SC, USA. + + + + eng + + Letter + + + 2023 + 02 + 21 + +
+ + United States + Obes Surg + 9106714 + 0960-8923 + + IM +
+ + + + 2023 + 01 + 20 + + + 2023 + 02 + 15 + + + 2023 + 01 + 20 + + + 2023 + 2 + 22 + 13 + 56 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809589 + 10.1007/s11695-023-06517-2 + 10.1007/s11695-023-06517-2 + + + + Eisenberg D, Shikora SA, Aarts E, et al. 2022 American Society of Metabolic and Bariatric Surgery (ASMBS) and International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO) indications for metabolic and bariatric surgery. Obes Surg. 2023;33:3–14. + + 10.1007/s11695-022-06332-1 + 36336720 + + + + Rubino F, Nathan DM, Eckel RH, et al. Metabolic surgery in the treatment algorithm for type 2 diabetes: a joints statement by international diabetes organizations. Obes Surg. 2017;27:2–21. + + 10.1007/s11695-016-2457-9 + 27957699 + + + + Aminian A, Chang J, Brethauer SA, et al. ASMBS updated position statement on bariatric surgery in class I obesity (BMI 30–35 kg/m2). Surg Obes Relat Dis. 2018;14:1071–87. + + 10.1016/j.soard.2018.05.025 + 30061070 + + + + Gutin I. In BMI we trust: reframing the body mass index as a measure of health. Soc Theory Health. 2018;16:256–71. + + 10.1057/s41285-017-0055-0 + 31007613 + + + + https://www.who.int/health-topics/obesity#tab=tab_1 . Accessed January 2023 + + + https://www.cdc.gov/ncbddd/disabilityandhealth/documents/obesityfactsheet2010.pdf . Accessed January 2023. + + + Must A, Spadano J, Coakley EH, et al. The disease burden associated with overweight and obesity. JAMA. 1999;282:1523–9. + + 10.1001/jama.282.16.1523 + 10546691 + + + + Adams KF, Schatzkin A, Harris TB, et al. Overweight, obesity, and mortality in a large prospective cohort of persons 50–71 years old. N Engl J Med. 2006;355:763–78. + + 10.1056/NEJMoa055643 + 16926275 + + + + Pischon T, Boeing H, Hoffmann K, et al. General and abdominal adiposity and risk of death in Europe. N Engl J Med 2008; 2105–20. + + + Ogassavara NC, Magalhaes Dias JG, Pajecki D, et al. The Edmonton Obesity Staging System: assessing a potential tool to improve the management of obesity surgery in the Brazilian public health services. Surg Obes Relat Dis. 2020;16:40–7. + + 10.1016/j.soard.2019.10.021 + 31796297 + + + + Sharma AM, Kushner RF. A proposed clinical staging system for obesity. Int J Obes (Lond). 2009;33:289–95. + + 10.1038/ijo.2009.2 + 19188927 + + + + Padwal RS, Pajewski NM, Allison DB, et al. CMAJ. 2011;183:e1059–66. + + 10.1503/cmaj.110387 + 21844111 + 3185097 + + + + Chiappetta S, Stier C, Squillante S, et al. The importance of the Edmonton Obesity Staging System in predicting postoperative outcome and 30-day mortality after metabolic surgery. Surg Obes Relat Dis. 2016;12:1847–55. + + 10.1016/j.soard.2016.02.042 + 27317606 + + + + Malczak P, Wysocki M, Dudek A, et al. Feasibility of modified Edmonton Obesity Staging System in bariatric center. Surg Obes Relat Dis. 2020;16:644–50. + + 10.1016/j.soard.2020.01.022 + 32122817 + + + + +
+ + + 36809583 + + 2023 + 02 + 22 + +
+ + 2198-3844 + + + 2023 + Feb + 21 + + + Advanced science (Weinheim, Baden-Wurttemberg, Germany) + Adv Sci (Weinh) + + Untethered Soft Microrobots with Adaptive Logic Gates. + + e2206662 + + 10.1002/advs.202206662 + + Integrating adaptative logic computation directly into soft microrobots is imperative for the next generation of intelligent soft microrobots as well as for the smart materials to move beyond stimulus-response relationships and toward the intelligent behaviors seen in biological systems. Acquiring adaptivity is coveted for soft microrobots that can adapt to implement different works and respond to different environments either passively or actively through human intervention like biological systems. Here, a novel and simple strategy for constructing untethered soft microrobots based on stimuli-responsive hydrogels that can switch logic gates according to the surrounding stimuli of environment is introduced. Different basic logic gates and combinational logic gates are integrated into a microrobot via a straightforward method. Importantly, two kinds of soft microrobots with adaptive logic gates are designed and fabricated, which can smartly switch logic operation between AND gate and OR gate under different surrounding environmental stimuli. Furthermore, a same magnetic microrobot with adaptive logic gate is used to capture and release the specified objects through the change of the surrounding environmental stimuli based on AND or OR logic gate. This work contributes an innovative strategy to integrate computation into small-scale untethered soft robots with adaptive logic gates. + © 2023 The Authors. Advanced Science published by Wiley-VCH GmbH. + + + + Wang + Zichao + Z + + MOE Key Laboratory of Materials Physics and Chemistry in Extraordinary Conditions, Shaanxi Key Laboratory of Macromolecular Science and Technology, School of Chemistry and Chemical Engineering, Northwestern Polytechnical University, Xi'an, 710072, P. R. China. + + + + Zhang + Xuan + X + https://orcid.org/0000-0001-5414-3232 + + MOE Key Laboratory of Materials Physics and Chemistry in Extraordinary Conditions, Shaanxi Key Laboratory of Macromolecular Science and Technology, School of Chemistry and Chemical Engineering, Northwestern Polytechnical University, Xi'an, 710072, P. R. China. + + + + Wang + Yang + Y + + MOE Key Laboratory of Materials Physics and Chemistry in Extraordinary Conditions, Shaanxi Key Laboratory of Macromolecular Science and Technology, School of Chemistry and Chemical Engineering, Northwestern Polytechnical University, Xi'an, 710072, P. R. China. + + + + Fang + Ziyi + Z + + MOE Key Laboratory of Materials Physics and Chemistry in Extraordinary Conditions, Shaanxi Key Laboratory of Macromolecular Science and Technology, School of Chemistry and Chemical Engineering, Northwestern Polytechnical University, Xi'an, 710072, P. R. China. + + + + Jiang + He + H + + MOE Key Laboratory of Materials Physics and Chemistry in Extraordinary Conditions, Shaanxi Key Laboratory of Macromolecular Science and Technology, School of Chemistry and Chemical Engineering, Northwestern Polytechnical University, Xi'an, 710072, P. R. China. + + + + Yang + Qinglin + Q + + MOE Key Laboratory of Materials Physics and Chemistry in Extraordinary Conditions, Shaanxi Key Laboratory of Macromolecular Science and Technology, School of Chemistry and Chemical Engineering, Northwestern Polytechnical University, Xi'an, 710072, P. R. China. + + + + Zhu + Xuefeng + X + + MOE Key Laboratory of Materials Physics and Chemistry in Extraordinary Conditions, Shaanxi Key Laboratory of Macromolecular Science and Technology, School of Chemistry and Chemical Engineering, Northwestern Polytechnical University, Xi'an, 710072, P. R. China. + + + + Liu + Mingze + M + + MOE Key Laboratory of Materials Physics and Chemistry in Extraordinary Conditions, Shaanxi Key Laboratory of Macromolecular Science and Technology, School of Chemistry and Chemical Engineering, Northwestern Polytechnical University, Xi'an, 710072, P. R. China. + + + + Fan + Xiaodong + X + + MOE Key Laboratory of Materials Physics and Chemistry in Extraordinary Conditions, Shaanxi Key Laboratory of Macromolecular Science and Technology, School of Chemistry and Chemical Engineering, Northwestern Polytechnical University, Xi'an, 710072, P. R. China. + + + + Kong + Jie + J + + MOE Key Laboratory of Materials Physics and Chemistry in Extraordinary Conditions, Shaanxi Key Laboratory of Macromolecular Science and Technology, School of Chemistry and Chemical Engineering, Northwestern Polytechnical University, Xi'an, 710072, P. R. China. + + + + eng + + + 52003220 + National Natural Science Foundation of China + + + + G2019KY05109 + Fundamental Research Funds for the Central Universities + + + + G2020KY05303 + Fundamental Research Funds for the Central Universities + + + + 2020M673480 + China Postdoctoral Science Foundation + + + + 2020JQ-140 + Natural Science Basic Research Program of Shaanxi Province + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Adv Sci (Weinh) + 101664569 + 2198-3844 + + IM + + adaptive logic gates + conjugated logic gates + soft microrobots + stimuli-responsive hydrogels + +
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+ + 1618-7601 + + + 2023 + Feb + 21 + + + The European journal of health economics : HEPAC : health economics in prevention and care + Eur J Health Econ + + Assessing validity of the EQ-5D-5L proxy in children and adolescents with Duchenne muscular dystrophy or spinal muscular atrophy. + 10.1007/s10198-023-01574-x + + To assess the psychometric properties of the EuroQol-5-Dimension five-level instrument (EQ-5D-5L) proxy in caregivers of children and adolescents with Duchenne muscular dystrophy (DMD) or spinal muscular atrophy (SMA). + Data were collected using the EQ-5D-5L proxy for individuals with DMD or SMA, as reported by their caregivers. Ceiling and floor effects, reliability (Cronbach's alpha), convergent and divergent validity (Spearman's correlation coefficient and Bland-Altman plot) and known-group validity (analysis of variance) was used to assess the instrument's psychometric properties. + Totally, 855 caregivers completed the questionnaire. Significant floor effects were observed for most dimensions of the EQ-5D-5L in both SMA and DMD samples. The EQ-5D-5L was strongly correlated with the hypothesized subscales of the SF-12, which confirmed satisfactory convergent and divergent validity. The EQ-5D-5L can significantly differentiate between impaired functional groups for individuals, demonstrating satisfactory discriminative ability. The agreement between the EQ-5D-5L utility and EQ-VAS scores was poor. + Based on the measurement properties assessed in this study, the EQ-5D-5L proxy is a valid and reliable tool for measuring the health-related quality of life of individuals with DMD or SMA rated by caregivers. Further studies should examine the content validity of the EQ-5D as well as the performance of its young version in these two patient groups. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Xu + Richard Huan + RH + + Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong, China. + + + + Dai + Yi + Y + + Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. + + + + Ng + Shamay S M + SSM + + Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong, China. + + + + Tsang + Hector W H + HWH + + Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong, China. + + + Mental Health Research Centre, The Hong Kong Polytechnic University, Hong Kong, China. + + + + Zhang + Shuyang + S + + Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. shuyangzhang103@nrdrs.org. + + + + Dong + Dong + D + http://orcid.org/0000-0001-9784-6472 + + JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China. dongdong@cuhk.edu.hk. + + + + eng + + + 2019ZX09734001 + the '13th Five Year' National Science and Technology Major Project for New Drugs + + + + 2016YFC0901500 + National Key Research and Development Program of China + + + + 7192155 + Beijing Natural Science Foundation + + + + 2021-I2M-1-003 + Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Eur J Health Econ + 101134867 + 1618-7598 + + IM + + Caregiver + Duchenne muscular dystrophy + EQ-5D-5L + Proxy + Spinal muscular atrophy + Validity + +
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+ + + 36809587 + + 2023 + 02 + 22 + +
+ + 1432-2218 + + + 2023 + Feb + 21 + + + Surgical endoscopy + Surg Endosc + + Learning curve for inflatable mediastinoscopic and laparoscopic-assisted esophagectomy. + 10.1007/s00464-023-09903-0 + + To identify the morbidity that is associated with the learning curve of inflatable mediastinoscopic and laparoscopic-assisted esophagectomy (IMLE), and investigate the strategies to ride out the early period. + Our study included a retrospective series of 108 consecutive patients undergoing IMLE by a single surgeon with advanced training in minimally invasive esophageal surgery in independent practice at high-volume tertiary center from July 2017 to November 2020. The cumulative sum (CUSUM) method was used to analyze the learning curve. Patients were stratified into two groups in chronological order, defining the surgeon's early (Group 1: the first 27 cases) and late experience (Group 2: the next 81 cases). Intraoperative characteristics and short-term surgical outcomes were compared between the two groups. + A total of 108 patients were included. Three patients converted into thoracoscopic surgery. The number of patients with postoperative pulmonary infection was 16 (14.8%), and vocal cord palsy had occurred in 12 patients (11.1%). One patient died within 90 days after surgery. CUSUM plots revealed decreasing total operative time, thoracic procedure time, abdominal procedure time, assistant-adjustment time after patients 27, 17, 26, and 35, respectively. + IMLE is technically feasible, in terms of perioperative outcomes, for using as a radical surgery for thoracic esophageal cancer. For a surgeon experienced in minimally invasive esophageal surgery, experience of 27 cases is required to gain early proficiency of IMLE. + © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. + + + + Hu + Weipeng + W + + Department of Thoracic Surgery, West China Hospital, Sichuan University, No. 37, Guoxue Alley, Chengdu, Sichuan, China. + + + + Yuan + Peisong + P + + Department of Thoracic Surgery, West China Hospital, Sichuan University, No. 37, Guoxue Alley, Chengdu, Sichuan, China. + + + + Yuan + Yong + Y + + Department of Thoracic Surgery, West China Hospital, Sichuan University, No. 37, Guoxue Alley, Chengdu, Sichuan, China. + + + + Chen + Longqi + L + + Department of Thoracic Surgery, West China Hospital, Sichuan University, No. 37, Guoxue Alley, Chengdu, Sichuan, China. + + + + Hu + Yang + Y + http://orcid.org/0000-0002-5437-3457 + + Department of Thoracic Surgery, West China Hospital, Sichuan University, No. 37, Guoxue Alley, Chengdu, Sichuan, China. huyangthoracic@126.com. + + + + eng + + + 2018HXFH039 + 1•3•5 project for disciplines of excellence-Clinical Research Incubation Project, West China Hospital, Sichuan University + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Surg Endosc + 8806653 + 0930-2794 + + IM + + Esophageal cancer + Esophagectomy + IMLE + Learning cure + +
+ + + + 2022 + 10 + 23 + + + 2023 + 01 + 18 + + + 2023 + 2 + 22 + 13 + 56 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809587 + 10.1007/s00464-023-09903-0 + 10.1007/s00464-023-09903-0 + + + + Birkmeyer JD, Siewers AE, Finlayson EVA, Stukel TA, Lucas FL, Batista I, Welch HG, Wennberg DE (2002) Hospital volume and surgical mortality in the United States. N Engl J Med 346:1128–1137 + + 10.1056/NEJMsa012337 + 11948273 + + + + Straatman J, van der Wielen N, Cuesta MA, Daams F, Garcia JR, Bonavina L, Rosman C, van Berge Henegouwen MI, Gisbertz SS, van der Peet DL (2017) Minimally invasive versus open esophageal resection: three-year follow-up of the previously reported randomized controlled trial: the TIME trial. 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Dis Esophagus 30(10):1–8 + + 10.1093/dote/dox047 + 28859387 + + + + Nakauchi M, Uyama I, Suda K, Shibasaki S, Kikuchi K, Kadoya S, Ishida Y, Inaba K (2019) Robot-assisted mediastinoscopic esophagectomy for esophageal cancer: the first clinical series. Esophagus 16(1):85–92 + + 10.1007/s10388-018-0634-8 + 30074105 + + + + Wang J, Jiang NQ, Jiang B, Wang ZL, Zhang XY (2015) Mediastinoscopy-assisted oesophagectomy in T1 oesophageal cancer patients with serious comorbidities: a 5-year long-term follow-up. Interact Cardiovasc Thorac Surg 20(4):477–481 + + 10.1093/icvts/ivu433 + 25535180 + + + + Wang J, Wei N, Lu Y, Zhang X, Jiang N (2018) Mediastinoscopy-assisted esophagectomy for T2 middle and lower thoracic esophageal squamous cell carcinoma patients. 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Eur J Cardiothorac Surg 49(5):e141–e146 + + 10.1093/ejcts/ezw015 + 26905182 + + + + Lai Y, Zeng X, Zhou K, Zhou X, Liu Y, Hu Y (2021) End to end intussusception anastomosis decreases the risk of anastomotic leakage after neoadjvant chemoradiation and McKeown oesophagectomy. Radiother Oncol 158:285–292 + + 10.1016/j.radonc.2021.02.030 + 33662437 + + + + Mao C-Y, Yang Y-S, Yuan Y, Hu W-P, Zhao Y-F, Hu Y, Che G-W, Chen L-Q (2019) End-to-end versus end-to-side hand-sewn anastomosis for minimally invasive McKeown esophagectomy. Ann Surg Oncol 26(12):4062–4069 + + 10.1245/s10434-019-07630-2 + 31313034 + + + + Osugi H, Takemura M, Higashino M, Takada N, Lee S, Kinoshita H (2003) A comparison of video-assisted thoracoscopic oesophagectomy and radical lymph node dissection for squamous cell cancer of the oesophagus with open operation. 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+ + + 36809584 + + 2023 + 02 + 22 + +
+ + 1435-9456 + + + 2023 + Feb + 21 + + + Animal cognition + Anim Cogn + + Novel object recognition in Octopus maya. + 10.1007/s10071-023-01753-6 + + The Novel Object Recognition task (NOR) is widely used to study vertebrates' memory. It has been proposed as an adequate model for studying memory in different taxonomic groups, allowing similar and comparable results. Although in cephalopods, several research reports could indicate that they recognize objects in their environment, it has not been tested as an experimental paradigm that allows studying different memory phases. This study shows that two-month-old and older Octopus maya subjects can differentiate between a new object and a known one, but one-month-old subjects cannot. Furthermore, we observed that octopuses use vision and tactile exploration of new objects to achieve object recognition, while familiar objects only need to be explored visually. To our knowledge, this is the first time showing an invertebrate performing the NOR task similarly to how it is performed in vertebrates. These results establish a guide to studying object recognition memory in octopuses and the ontological development of that memory. + © 2023. The Author(s). + + + + Vergara-Ovalle + Fabian + F + + Neuropsychopharmacology Laboratory, Psychology School, Universidad Nacional Autónoma de México, colonia copilco universidad, Avenida Universidad 3000, 1er Piso Edif. B. Cub B001, Alcaldía de Coyoacan, Ciudad Universitaria, Coyoacán, CP 04510, Mexico City, Mexico. + + + + Ayala-Guerrero + Fructuoso + F + + Neurosciences Laboratory, Psychology School, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán, 04510, Mexico City, Mexico. + + + + Rosas + Carlos + C + + Applied Ecophysiology Laboratory, Facultad de Ciencias, Unidad Multidisciplinaria para Investigación y Educación, Universidad Nacional Autónoma de México, Puerto de abrigo s/n Sisal, Yucatán, Mexico. + + + + Sánchez-Castillo + Hugo + H + http://orcid.org/0000-0002-7335-9335 + + Neuropsychopharmacology Laboratory, Psychology School, Universidad Nacional Autónoma de México, colonia copilco universidad, Avenida Universidad 3000, 1er Piso Edif. B. Cub B001, Alcaldía de Coyoacan, Ciudad Universitaria, Coyoacán, CP 04510, Mexico City, Mexico. hugosancas@comunidad.unam.mx. + + + + eng + + + IN 208722 + DGAPA-PAPIIT + + + + + Journal Article + + + 2023 + 02 + 21 + +
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J Comp Physiol Psychol 55(6):939–943. https://doi.org/10.1037/h0040049 + + 10.1037/h0040049 + 13979399 + + + + Tanimizu T, Kono K, Kida S (2017) Brain networks activated to form object recognition memory. Brain Res Bull 141:27–34. https://doi.org/10.1016/j.brainresbull.2017.05.017 + + 10.1016/j.brainresbull.2017.05.017 + 28587862 + + + + Tomita M, Aoki S (2014) visual discrimination learning in the small octopus Octopus ocellatus. Ethology. https://doi.org/10.1111/eth.12258 + + 10.1111/eth.12258 + + + + Toms C, Echevarria D (2014) Back to basics: searching for a comprehensive framework for exploring individual differences in zebrafish (Danio renio) behavior. Zebrafish 11(4):325–340. https://doi.org/10.1089/zeb.2013.0952 + + 10.1089/zeb.2013.0952 + 24921670 + + + + Tricarico E, Borrelli L, Gherardi F, Fiorito G (2011) I know my neighbour: individual recognition in Octopus vulgaris. PLoS ONE 6(4):e18710. https://doi.org/10.1371/journal.pone.0018710 + + 10.1371/journal.pone.0018710 + 21533257 + 3076440 + + + + Vergara-Ovalle F, Gonzalez-Navarrete A, Sánchez-Castillo H (2022) Characterization of the Brain of the Red Mayan Octopus (Octopus maya Voss and Solis, 1966). J Evol Biochem Phys 58:1401–1412. https://doi.org/10.1134/S0022093022050118 + + 10.1134/S0022093022050118 + + + + Voss G, Solís-Ramírez M (1966) Octopus maya, a new species from the Bay of Campeche. Bull Mar Sci 16:615 + + + Wells M, Young J (1975) The subfrontal lobe and touch learning in the octopus. Brain Res 92(1):103–121. https://doi.org/10.1016/0006-8993(75)90530-2 + + 10.1016/0006-8993(75)90530-2 + 1174937 + + + + Zarrella I, Ponte G, Baldascino E, Fiorito G (2015) Learning and memory in Octopus vulgaris: a case of biological plasticity. Curr Opin Neurobiol 35:74–79. https://doi.org/10.1016/j.conb.2015.06.012 + + 10.1016/j.conb.2015.06.012 + 26186237 + + + + +
+ + + 36809588 + + 2023 + 02 + 22 + +
+ + 1432-2218 + + + 2023 + Feb + 21 + + + Surgical endoscopy + Surg Endosc + + Effects of ondansetron, metoclopramide and granisetron on perioperative nausea and vomiting in patients undergone bariatric surgery: a randomized clinical trial. + 10.1007/s00464-023-09939-2 + + Post-operative nausea and vomiting (PONV) is a common problem after sleeve gastrectomy. In recent years, following the increase in the number of such operations, special attention has been paid to preventing PONV. Additionally, several prophylaxis methods have been developed, including enhanced recovery after surgery (ERAS) and preventive antiemetics. Nevertheless, PONV has not been completely eliminated, and the clinicians are trying to reduce the incidence of PONV yet. + After successful ERAS implementation, patients were divided into five groups, including control and experimental groups. Metoclopramide (MA), ondansetron (OA), granisetron (GA), and a combination of metoclopramide and ondansetron (MO) were used as antiemetics for each group. The frequency of PONV during the first and second days of admission was recorded using a subjective PONV scale. + A total of 130 patients were enrolled in this study. The MO group showed a lower incidence of PONV (46.1%) compared to the control group (53.8%) and other groups. Furthermore, the MO group did not require rescue antiemetics, however, one-third of control cases used rescue antiemetics (0 vs. 34%). + Using the combination of metoclopramide and ondansetron is recommended as the antiemetic regimen for the reduction of PONV after sleeve gastrectomy. This combination is more helpful when implemented alongside ERAS protocols. + © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. + + + + Ebrahimian + Manoochehr + M + http://orcid.org/0000-0003-1286-3308 + + Department of General Surgery, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. manoochehrebrahimian@sbmu.ac.ir. + + + + Mirhashemi + Seyed-Hadi + SH + + Department of General Surgery, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. + + + + Oshidari + Bahador + B + + Department of General Surgery, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. + + + + Zamani + Amir + A + + Department of General Surgery, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. + + + + Shadidi-Asil + Roozbeh + R + + Department of General Surgery, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. + + + + Kialashaki + Mehrnoosh + M + + Department of General Surgery, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. + + + + Ghayebi + Negin + N + + School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Surg Endosc + 8806653 + 0930-2794 + + IM + + Bariatric surgery + Granisetron + Metoclopramide + Ondansetron + Postoperative nausea or vomiting + Sleeve gastrectomy + +
+ + + + 2022 + 11 + 07 + + + 2023 + 02 + 05 + + + 2023 + 2 + 22 + 13 + 56 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809588 + 10.1007/s00464-023-09939-2 + 10.1007/s00464-023-09939-2 + + + + Fathy M, Abdel-Razik MA, Elshobaky A et al (2019) Impact of pyloric injection of magnesium sulfate-lidocaine mixture on postoperative nausea and vomiting after laparoscopic sleeve gastrectomy: a randomized-controlled trial. Obes Surg 29(5):1614–1623 + + 10.1007/s11695-019-03762-2 + 30734195 + + + + Parisi A, Desiderio J, Cirocchi R et al (2020) Enhanced recovery after surgery (ERAS): a systematic review of randomised controlled trials (RCTs) in bariatric surgery. Obes Surg 30(12):5071–5085 + + 10.1007/s11695-020-05000-6 + 32981000 + + + + Isazadehfar K, Entezariasl M, Shahbazzadegan B et al (2017) The comparative study of ondansetron and metoclopramide effects in reducing nausea and vomiting after laparoscopic cholecystectomy. Acta Med Iran 55(4):254–258 + + 28532137 + + + + Weibel S, Rücker G, Eberhart LH et al (2020) Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis. Cochrane Database Syst Rev 10(10):Cd012859 + + 33075160 + + + + Thorell A, MacCormick AD, Awad S et al (2016) Guidelines for perioperative care in bariatric surgery: enhanced recovery after surgery (ERAS) society recommendations. World J Surg 40(9):2065–2083 + + 10.1007/s00268-016-3492-3 + 26943657 + + + + Palermo M, Gagner M (2020) Why we think laparoscopic sleeve gastrectomy is a good operation: step-by-step technique. J Laparoendosc Adv Surg Tech 30(6):615–618 + + 10.1089/lap.2020.0154 + + + + Glaysher M, Khan OA, Mabvuure NT et al (2013) Staple line reinforcement during laparoscopic sleeve gastrectomy: does it affect clinical outcomes? Int J Surg 11(4):286–289 + + 10.1016/j.ijsu.2013.02.015 + 23459188 + + + + Di Lorenzo N, Antoniou SA, Batterham RL et al (2020) Clinical practice guidelines of the european association for endoscopic surgery (EAES) on bariatric surgery: update 2020 endorsed by IFSO-EC, EASO and ESPCOP. Surg Endosc 34(6):2332–2358 + + 10.1007/s00464-020-07555-y + 32328827 + 7214495 + + + + Schulz KF, Altman DG, Moher D (2010) CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. Trials 11(1):1–8 + + 10.1186/1745-6215-11-32 + + + + Rondina MT, Wheeler M, Rodgers GM et al (2010) Weight-based dosing of enoxaparin for VTE prophylaxis in morbidly obese, medically-Ill patients. Thromb Res 125(3):220–223 + + 10.1016/j.thromres.2009.02.003 + 19272635 + + + + Myles PS, Wengritzky R (2012) Simplified postoperative nausea and vomiting impact scale for audit and post-discharge review. Br J Anaesth 108(3):423–429 + + 10.1093/bja/aer505 + 22290456 + + + + Chey WD, Wong BC, Gastroenterology PPCotACo (2007) American college of gastroenterology guideline on the management of helicobacter pylori infection. Off J Am Coll Gastroenterol 102(8):1808–1825 + + 10.1111/j.1572-0241.2007.01393.x + + + + Selgrad M, Malfertheiner P (2011) Treatment of helicobacter pylori. Curr Opin Gastroenterol 27(6):565–570 + + 10.1097/MOG.0b013e32834bb818 + 21946029 + + + + Wolters U, Wolf T, Stützer H et al (1996) ASA classification and perioperative variables as predictors of postoperative outcome. Br J Anaesth 77(2):217–222 + + 10.1093/bja/77.2.217 + 8881629 + + + + Borm GF, Fransen J, Lemmens WA (2007) A simple sample size formula for analysis of covariance in randomized clinical trials. J Clin Epidemiol 60(12):1234–1238 + + 10.1016/j.jclinepi.2007.02.006 + 17998077 + + + + Faul F, Erdfelder E, Buchner A et al (2009) Statistical power analyses using G* Power 3.1: tests for correlation and regression analyses. Behav Res Methods 41(4):1149–1160 + + 10.3758/BRM.41.4.1149 + 19897823 + + + + Weilbach C, Rahe-Meyer N, Raymondos K et al (2006) Postoperative nausea and vomiting (PONV): usefulness of the Apfel-score for identification of high risk patients for PONV. Acta Anaesthesiol Belg 57(4):361–363 + + 17236637 + + + + Feldheiser A, Aziz O, Baldini G et al (2016) Enhanced recovery after surgery (ERAS) for gastrointestinal surgery, part 2: consensus statement for anaesthesia practice. Acta Anaesthesiol Scand 60(3):289–334 + + 10.1111/aas.12651 + 26514824 + + + + Franco JVA, Ruiz PA, Palermo M et al (2011) A review of studies comparing three laparoscopic procedures in bariatric surgery: sleeve gastrectomy, Roux-en-Y gastric bypass and adjustable gastric banding. Obes Surg 21(9):1458–1468 + + 10.1007/s11695-011-0390-5 + 21455833 + + + + Naeem Z, Chen IL, Pryor AD et al (2020) Antiemetic prophylaxis and anesthetic approaches to reduce postoperative nausea and vomiting in bariatric surgery patients: a systematic review. Obes Surg 30(8):3188–3200 + + 10.1007/s11695-020-04683-1 + 32415635 + + + + Halliday TA, Sundqvist J, Hultin M et al (2017) Post-operative nausea and vomiting in bariatric surgery patients: an observational study. Acta Anaesthesiol Scand 61(5):471–479 + + 10.1111/aas.12884 + 28374473 + + + + Moussa AA, Oregan PJ (2007) Prevention of postoperative nausea and vomiting in patients undergoing laparoscopic bariatric surgery–granisetron alone vs granisetron combined with dexamethasone/droperidol. Middle East J Anaesthesiol 19(2):357–367 + + 17684876 + + + + Mendes MN, Monteiro RDS, Martins FANDC (2009) Prophylaxis of postoperative nausea and vomiting in morbidly obese patients undergoing laparoscopic gastroplasties: a comparative study among three methods. Rev Bras Anestesiol 59:570–576 + + 19784512 + + + + Benevides ML, de Souza Oliveira SS, de Aguilar-Nascimento JE (2013) The combination of haloperidol, dexamethasone, and ondansetron for prevention of postoperative nausea and vomiting in laparoscopic sleeve gastrectomy: a randomized double-blind trial. Obes Surg 23(9):1389–1396 + + 10.1007/s11695-013-0923-1 + 23529851 + + + + Bamgbade OA, Oluwole O, Khaw RR (2018) Perioperative antiemetic therapy for fast-track laparoscopic bariatric surgery. Obes Surg 28(5):1296–1301 + + 10.1007/s11695-017-3009-7 + 29116559 + + + + Ziemann-Gimmel P, Goldfarb A, Koppman J et al (2014) Opioid-free total intravenous anaesthesia reduces postoperative nausea and vomiting in bariatric surgery beyond triple prophylaxis. Br J Anaesth 112(5):906–911 + + 10.1093/bja/aet551 + 24554545 + + + + Sinha AC, Singh PM, Williams NW et al (2014) Aprepitant’s prophylactic efficacy in decreasing postoperative nausea and vomiting in morbidly obese patients undergoing bariatric surgery. Obes Surg 24(2):225–231 + + 10.1007/s11695-013-1065-1 + 23990451 + + + + Bataille A, Letourneulx J-F, Charmeau A et al (2016) Impact of a prophylactic combination of dexamethasone–ondansetron on postoperative nausea and vomiting in obese adult patients undergoing laparoscopic sleeve gastrectomy during closed-loop propofol–remifentanil anaesthesia: a randomised double-blind placebo-controlled study. Eur J Anaesthesiol 33(12):898–905 + + 10.1097/EJA.0000000000000427 + 26866433 + + + + Talebpour M, Omrani NG, Imani F et al (2017) Comparison effect of promethazine/dexamethasone and metoclopramide/dexamethasone on postoperative nausea and vomiting after laparascopic gastric placation: a randomized clinical trial. Anesthesiol Pain Med. https://doi.org/10.5812/aapm.57810 + + 10.5812/aapm.57810 + + + + Wu SJ, Xiong XZ, Cheng TY et al (2012) Efficacy of ondansetron vs. metoclopramide in prophylaxis of postoperative nausea and vomiting after laparoscopic cholecystectomy: a systematic review and meta-analysis. Hepatogastroenterology 59(119):2064–2074 + + 22282127 + + + + +
+ + + 36809590 + + 2023 + 02 + 22 + +
+ + 1573-2576 + + + 2023 + Feb + 21 + + + Inflammation + Inflammation + + Correction to: Sema3A Drives Alternative Macrophage Activation in the Resolution of Periodontitis via PI3K/AKT/mTOR Signaling. + 10.1007/s10753-023-01788-4 + + + Tian + Tian + T + + Department of Endodontics, Shenzhen Stomatology Hospital (Pingshan), Southern Medical University, No. 143, Dongzong Road, Pingshan District, Shenzhen, 518118, China. + + + + Chen + Leyi + L + + Department of Endodontics, Shenzhen Stomatology Hospital (Pingshan), Southern Medical University, No. 143, Dongzong Road, Pingshan District, Shenzhen, 518118, China. + + + School of Stomatology, Southern Medical University, Guangzhou, 510515, China. + + + + Wang + Ziting + Z + + Department of Pediatric Dentistry, Shenzhen Stomatology Hospital (Pingshan), Southern Medical University, No. 143, Dongzong Road, Pingshan District, Shenzhen, 518118, China. + + + School of Stomatology, Southern Medical University, Guangzhou, 510515, China. + + + + Zhu + Mingqi + M + + Department of Endodontics, Shenzhen Stomatology Hospital (Pingshan), Southern Medical University, No. 143, Dongzong Road, Pingshan District, Shenzhen, 518118, China. + + + School of Stomatology, Southern Medical University, Guangzhou, 510515, China. + + + + Xu + Wenan + W + + Department of Pediatric Dentistry, Shenzhen Stomatology Hospital (Pingshan), Southern Medical University, No. 143, Dongzong Road, Pingshan District, Shenzhen, 518118, China. venus_200@163.com. + + + School of Stomatology, Southern Medical University, Guangzhou, 510515, China. venus_200@163.com. + + + + Wu + Buling + B + + Department of Endodontics, Shenzhen Stomatology Hospital (Pingshan), Southern Medical University, No. 143, Dongzong Road, Pingshan District, Shenzhen, 518118, China. bulingwu@smu.edu.cn. + + + School of Stomatology, Southern Medical University, Guangzhou, 510515, China. bulingwu@smu.edu.cn. + + + + eng + + Published Erratum + + + 2023 + 02 + 21 + +
+ + United States + Inflammation + 7600105 + 0360-3997 + + IM + + + Inflammation. 2023 Jan 4;: + 36598593 + + +
+ + + + 2023 + 2 + 22 + 13 + 56 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809590 + 10.1007/s10753-023-01788-4 + 10.1007/s10753-023-01788-4 + + +
+ + + 36809582 + + 2023 + 02 + 22 + +
+ + 1590-1262 + + 28 + 1 + + 2023 + Feb + 21 + + + Eating and weight disorders : EWD + Eat Weight Disord + + The factors associated with orthorexia nervosa in type 2 diabetes and their effect on diabetes self-management scores. + + 22 + + 10.1007/s40519-023-01552-5 + + This study aimed to determine the factors affecting the ORTO-R scores in individuals with T2DM and to investigate their effect on diabetes self-management. + The study included 373 individuals with type 2 diabetes between the ages of 18-65 who applied to Akdeniz University Hospital Endocrinology and Metabolic Diseases Polyclinic between January and May 2022. A questionnaire including sociodemographic data, information about diabetes, and nutritional habits, and the ORTO-R and Type 2 Diabetes Self-Management Scales were used to collect data. Linear regression analysis was performed to determine the factors affecting ORTO-R. + The linear regression analysis showed that age, gender, education level, and duration of diabetes affected ORTO-R scores in patients with type 2 diabetes. Body mass index, comorbidities (cardiovascular diseases, kidney diseases and hypertension), diabetes-related complications, diabetes treatment method and dieting had no significant contribution to the model (p > 0.05). We also found that education level, comorbidities, diabetes-related complications, diabetes treatment method, dieting, and BMI can affect diabetes self-management. + It should be kept in mind that type 2 diabetes are at risk of orthorexia nervosa (ON) in terms of various aspects such as age, gender, education level and duration of diabetes. Since the factors affecting the risk of ON and the factors affecting diabetes self-management are intertwined, orthorexic tendencies should be kept under control while trying to increase self-management in these patients. In this respect, developing individual recommendations according to the psychosocial characteristics of patients may be an effective approach. + Level V, cross-sectional study. + © 2023. The Author(s). + + + + Kamarli Altun + Hülya + H + http://orcid.org/0000-0001-9878-9297 + + Department of Nutrition and Dietetics, Faculty of Health Sciences, Akdeniz University, Dumlupinar Boulevard, Campus, 07058, Antalya, Türkiye. + + + + Özyildirim + Caner + C + http://orcid.org/0000-0001-8227-9575 + + Department of Nutrition and Dietetics, Faculty of Health Sciences, Akdeniz University, Dumlupinar Boulevard, Campus, 07058, Antalya, Türkiye. canerozyildirim@hotmail.com. + + + + Koç + Şeyma + Ş + + Department of Nutrition and Dietetics, Faculty of Health Sciences, Akdeniz University, Dumlupinar Boulevard, Campus, 07058, Antalya, Türkiye. + + + + Aksoy + Hatice Nur + HN + + Department of Nutrition and Dietetics, Faculty of Health Sciences, Akdeniz University, Dumlupinar Boulevard, Campus, 07058, Antalya, Türkiye. + + + + Sağir + Beyza + B + + Department of Nutrition and Dietetics, Faculty of Health Sciences, Akdeniz University, Dumlupinar Boulevard, Campus, 07058, Antalya, Türkiye. + + + + Bozkurt + Merve Sefa + MS + + Department of Nutrition and Dietetics, Faculty of Health Sciences, Akdeniz University, Dumlupinar Boulevard, Campus, 07058, Antalya, Türkiye. + + + + Karasu + Hakan + H + + Department of Nutrition and Dietetics, Faculty of Health Sciences, Akdeniz University, Dumlupinar Boulevard, Campus, 07058, Antalya, Türkiye. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Eat Weight Disord + 9707113 + 1124-4909 + + IM + + Diabetes self-management + Diet + Orthorexia nervosa + Type 2 diabetes + +
+ + + + 2022 + 07 + 26 + + + 2023 + 02 + 10 + + + 2023 + 2 + 22 + 13 + 56 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809582 + 10.1007/s40519-023-01552-5 + 10.1007/s40519-023-01552-5 + + + + American Diabetes Association Professional Practice Committee (2022) 8. Obesity and weight management for the prevention and treatment of type 2 diabetes: standards of medical care in diabetes—2022. Diabetes Care 45:S113–S124. https://doi.org/10.2337/dc22-S008 + + 10.2337/dc22-S008 + + + + Sun H, Saeedi P, Karuranga S et al (2022) IDF Diabetes Atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res Clin Pract 183:109119. https://doi.org/10.1016/j.diabres.2021.109119 + + 10.1016/j.diabres.2021.109119 + 34879977 + + + + American Diabetes Association (2019) 5. Lifestyle management: standards of medical care in diabetes—2019. Diabetes Care 42:S46–S60. https://doi.org/10.2337/dc19-S005 + + 10.2337/dc19-S005 + + + + Ogurtsova K, da Rocha Fernandes JD, Huang Y et al (2017) IDF Diabetes Atlas: global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes Res Clin Pract 128:40–50. https://doi.org/10.1016/j.diabres.2017.03.024 + + 10.1016/j.diabres.2017.03.024 + 28437734 + + + + Worswick J, Wayne SC, Bennett R et al (2013) Improving quality of care for persons with diabetes: an overview of systematic reviews—what does the evidence tell us? Syst Rev 2:26. https://doi.org/10.1186/2046-4053-2-26 + + 10.1186/2046-4053-2-26 + 23647654 + 3667096 + + + + Powers MA, Bardsley J, Cypress M et al (2016) Diabetes self-management education and support in type 2 diabetes: a joint position statement of the American Diabetes Association, the American Association of Diabetes Educators, and the Academy of Nutrition and Dietetics. 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+ + + 36809598 + + 2023 + 02 + 22 + +
+ + 1573-2592 + + + 2023 + Feb + 21 + + + Journal of clinical immunology + J Clin Immunol + + Real-World Evidence of Tolerability of 20% Subcutaneous Immunoglobulin Treatment. + 10.1007/s10875-023-01436-4 + + The safety and efficacy of subcutaneous immune globulin 20% (human) solution (Ig20Gly) were demonstrated in clinical trials. However, real-world evidence of the tolerability of self-administered Ig20Gly in elderly patients is lacking. We describe real-world patterns of Ig20Gly usage for 12 months in patients with primary immunodeficiency diseases (PIDD) in the USA. + This retrospective chart review of longitudinal data from 2 centers included patients aged ≥ 2 years with PIDD. Ig20Gly administration parameters, tolerability, and usage patterns were assessed at initial and subsequent 6- and 12-month infusions. + Of 47 enrolled patients, 30 (63.8%) received immunoglobulin replacement therapy (IGRT) within 12 months before starting Ig20Gly, and 17 (36.2%) started IGRT de novo. Patients were predominantly White (89.1%), female (85.1%), and elderly (aged > 65 years, 68.1%; median age = 71.0 years). Most adults received at-home treatment during the study, and most self-administered at 6 months (90.0%) and 12 months (88.2%). Across all time points, infusions were administered at a mean rate of 60-90 mL/h/infusion, using a mean of 2 sites per infusion, on a weekly or biweekly frequency. No emergency department visits occurred, and hospital visits were rare (n = 1). Forty-six adverse drug reactions occurred in 36.4% of adults, mostly localized site reactions; none of these or any adverse events led to treatment discontinuation. + These findings demonstrate tolerability and successful self-administration of Ig20Gly in PIDD, including elderly patients and patients starting IGRT de novo. + © 2023. The Author(s). + + + + Rosenbach + Kevin + K + + Naples Allergy Center, Naples, FL, USA. + + + + Park + Michelle + M + + Takeda Development Center Americas, Inc., Cambridge, MA, USA. + + + + Sanchirico + Marie + M + http://orcid.org/0000-0001-9985-5583 + + Takeda Pharmaceuticals USA, Inc., Lexington, MA, USA. marie.sanchirico@takeda.com. + + + + Nwose + Oliseyenum + O + + Takeda Pharmaceuticals USA, Inc., Lexington, MA, USA. + + + + Paris + Kenneth + K + + Department of Pediatrics, Louisiana State University Health Sciences Center, Children's Hospital, New Orleans, LA, USA. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Netherlands + J Clin Immunol + 8102137 + 0271-9142 + + IM + + Ig20Gly + Subcutaneous immunoglobulin + chart review + immunoglobulin replacement therapy + inborn errors of immunity + primary immunodeficiency diseases + real-world experience + real-world usage + +
+ + + + 2022 + 05 + 27 + + + 2023 + 01 + 19 + + + 2023 + 2 + 22 + 13 + 57 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809598 + 10.1007/s10875-023-01436-4 + 10.1007/s10875-023-01436-4 + + + + El-Sayed ZA, Abramova I, Aldave JC, Al-Herz W, Bezrodnik L, Boukari R, et al. X-linked agammaglobulinemia (XLA):phenotype, diagnosis, and therapeutic challenges around the world. World Allergy Organ J. 2019;12(3):100018. + + 10.1016/j.waojou.2019.100018 + 30937141 + 6439403 + + + + Bousfiha A, Jeddane L, Picard C, Al-Herz W, Ailal F, Chatila T, et al. Human inborn errors of immunity: 2019 update of the IUIS Phenotypical Classification. J Clin Immunol. 2020;40(1):66–81. + + 10.1007/s10875-020-00758-x + 32048120 + 7082388 + + + + Bonilla FA, Khan DA, Ballas ZK, Chinen J, Frank MM, Hsu JT, et al. Practice parameter for the diagnosis and management of primary immunodeficiency. J Allergy Clin Immunol. 2015;136(5):1186–205.e1–78. + + + Tangye SG, Al-Herz W, Bousfiha A, Chatila T, Cunningham-Rundles C, Etzioni A, et al. Human inborn errors of immunity: 2019 update on the classification from the International Union of Immunological Societies Expert Committee. J Clin Immunol. 2020;40(1):24–64. + + 10.1007/s10875-019-00737-x + 31953710 + 7082301 + + + + Pollock RF, Meckley LM. An evaluation of the budget impact of a new 20% subcutaneous immunoglobulin (Ig20Gly) for the management of primary immunodeficiency diseases in Switzerland. Clinicoecon Outcomes Res. 2018;10:223–9. + + 10.2147/CEOR.S155641 + 29692618 + 5901127 + + + + Berger M, Murphy E, Riley P, Bergman GE, Investigators VT. Improved quality of life, immunoglobulin G levels, and infection rates in patients with primary immunodeficiency diseases during self-treatment with subcutaneous immunoglobulin G. South Med J. 2010;103(9):856–63. + + 10.1097/SMJ.0b013e3181eba6ea + 20689467 + + + + Borte M, Krivan G, Derfalvi B, Marodi L, Harrer T, Jolles S, et al. Efficacy, safety, tolerability and pharmacokinetics of a novel human immune globulin subcutaneous, 20%: a Phase 2/3 study in Europe in patients with primary immunodeficiencies. Clin Exp Immunol. 2017;187(1):146–59. + + 10.1111/cei.12866 + 27613250 + + + + CUVITRU. Immune globulin subcutaneous (human), 20% solution [prescribing information]. Lexington, MA: Baxalta US Inc.; 2019. + + + Suez D, Stein M, Gupta S, Hussain I, Melamed I, Paris K, et al. Efficacy, safety, and pharmacokinetics of a novel human immune globulin subcutaneous, 20 % in patients with primary immunodeficiency diseases in North America. J Clin Immunol. 2016;36(7):700–12. + + 10.1007/s10875-016-0327-9 + 27582171 + 5018260 + + + + Suez D, Krivan G, Jolles S, Stein M, Gupta S, Paris K, et al. Safety and tolerability of subcutaneous immunoglobulin 20% in primary immunodeficiency diseases from two continents. Immunotherapy. 2019;11(12):1057–65. + + 10.2217/imt-2019-0057 + 31268374 + + + + Paris K, Haddad E, Borte M, Brodszki N, Derfalvi B, Marodi L, et al. Tolerability of subcutaneous immunoglobulin 20%, Ig20Gly, in pediatric patients with primary immunodeficiencies. Immunotherapy. 2019;11(5):397–406. + + 10.2217/imt-2018-0088 + 30626238 + + + + Meckley LM, Wu Y, Tzivelekis S, Gandhi V, Gladiator A. Infusion parameters of 20% subcutaneous immunoglobulin for primary immunodeficiency diseases among patient support program participants. Ann Allergy Asthma Immunol. 2021;127(5):568–74 e1. + + 10.1016/j.anai.2021.06.023 + 34224864 + + + + Stein MR, Koterba A, Rodden L, Berger M. Safety and efficacy of home-based subcutaneous immunoglobulin G in elderly patients with primary immunodeficiency diseases. Postgrad Med. 2011;123(5):186–93. + + 10.3810/pgm.2011.09.2474 + 21904101 + + + + Langford J, Herrscher R, Mehta S, Hames J, Van Anglen L. P252 real-world evaluation of immune globulin subcutaneous 16.5% in the treatment of primary immunodeficiency: six-month outcomes. Ann Allergy Asthma Immunol. 2020;125(5):AB72. + + + Herrscher R, Langford J, Kuten S, Van Anglen L. Real-world evaluation of efficacy and tolerability of immune globulin subcutaneous 16.5% in the treatment of patients with primary immunodeficiency. J Allergy Clin Immunol. 2020;145(2):AB33. + + + Borte M, Ritchie B, Plebani A, McCusker C, Fernández-Cruz E, Schmidt DS, et al. Improvement in quality of life measurements in newly diagnosed patients with primary immunodeficiency receiving directly initiated subcutaneous replacement therapy with vivaglobin. J Allergy Clin Immunol. 2010;125(2):AB140. + + + Duff C, Leiding JW. 5165: Initiation of 20% subcutaneous immunoglobulin therapy in patients with primary immunodeficiency naïve to IG therapy. J Clin Immunol. 2017;37(2):197–266. + + + Koterba AP, Stein MR. Initiation of immunoglobulin therapy by subcutaneous administration in immunodeficiency patients naive to replacement therapy. Allergy Asthma Clin Immunol. 2015;11(1):63. + + 10.1186/s13223-014-0063-8 + 25535489 + + + + Walter G, Kalicinsky C, Warrington R, Miguel M, Reyes J, Rubin TS. Delivery of subcutaneous immunoglobulin by rapid "push" infusion for primary immunodeficiency patients in Manitoba: a retrospective review. Allergy Asthma Clin Immunol. 2020;16:34. + + 10.1186/s13223-020-00431-3 + 32426003 + 7218483 + + + + +
+ + + 36809597 + + 2023 + 02 + 22 + +
+ + 1573-2592 + + + 2023 + Feb + 21 + + + Journal of clinical immunology + J Clin Immunol + + Unwinding the Role of the CMG Helicase in Inborn Errors of Immunity. + 10.1007/s10875-023-01437-3 + + + Guilz + Nicole C + NC + + Vagelos College of Physicians and Surgeons, Department of Pediatrics, Columbia University Irving Medical Center, 630 W 168th St., New York, NY, 10032, USA. + + + + Ahn + Yong-Oon + YO + + Vagelos College of Physicians and Surgeons, Department of Pediatrics, Columbia University Irving Medical Center, 630 W 168th St., New York, NY, 10032, USA. + + + + Seo + Seungmae + S + + Vagelos College of Physicians and Surgeons, Department of Pediatrics, Columbia University Irving Medical Center, 630 W 168th St., New York, NY, 10032, USA. + + + + Mace + Emily M + EM + http://orcid.org/0000-0003-0226-7393 + + Vagelos College of Physicians and Surgeons, Department of Pediatrics, Columbia University Irving Medical Center, 630 W 168th St., New York, NY, 10032, USA. em3375@cumc.columbia.edu. + + + + eng + + + R01AI137275 + National Institute of Allergy and Infectious Diseases + + + + + Editorial + + + 2023 + 02 + 21 + +
+ + Netherlands + J Clin Immunol + 8102137 + 0271-9142 + + IM +
+ + + + 2022 + 10 + 31 + + + 2023 + 01 + 20 + + + 2023 + 2 + 22 + 13 + 57 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809597 + 10.1007/s10875-023-01437-3 + 10.1007/s10875-023-01437-3 + + + + Tangye SG, Al-Herz W, Bousfiha A, Cunningham-Rundles C, Franco JL, Holland SM, et al. Human inborn errors of immunity: 2022 update on the classification from the International Union of Immunological Societies Expert Committee. J Clin Immunol. 2022;42(7):1473–507. + + 35748970 + 9244088 + 10.1007/s10875-022-01289-3 + + + + Mace EM, Orange JS. Emerging insights into human health and NK cell biology from the study of NK cell deficiencies. Immunol Rev. 2019;287(1):202–25. + + 30565241 + 6310041 + 10.1111/imr.12725 + + + + Della Chiesa M, De Maria A, Muccio L, Bozzano F, Sivori S, Moretta L. Human NK Cells and herpesviruses: mechanisms of recognition, response and adaptation. 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+ + + 36809593 + + 2023 + 02 + 22 + +
+ + 1543-706X + + + 2023 + Feb + 21 + + + In vitro cellular & developmental biology. Animal + In Vitro Cell Dev Biol Anim + + Derivation and characterization of new cell line from intestine of turbot (Scophthalmus maximus). + 10.1007/s11626-022-00746-y + + A continuous intestine cell line from turbot (Scophthalmus maximus) designated as SMI was established utilizing the tissue explant technique. Primary SMI cell was cultured at 24 °C in a medium with 20% fetal bovine serum (FBS), then subcultured in 10% FBS after 10 passages. Impacts of medium or temperature on the growth of SMI were examined and the results indicated it grew well in DMEM supplemented with 10% FBS at 24 °C. The SMI cell line was subcultured more than 60 times. Karyotyping, chromosome number, and ribosomal RNA genotyping analysis revealed that SMI had a modal diploid chromosome number of 44 and originated from turbot. After being transfected with pEGFP-N1 and FAM-siRNA, a large number of green fluorescence signals were observed in SMI, indicating that SMI could be used as an ideal platform to explore gene function in vitro. In addition, the expression of epithelium-associated genes such as itga6, itgb4, gja1, claudin1, zo-1, and E-cadherin in SMI suggested the SMI had some characteristics of epidermal cells. The upregulation of immune-associated genes such as TNF-β, NF-κB, and IL-1β in SMI after stimulation with pathogen-associated molecular patterns suggested the SMI might exhibit immune functions similar to the intestinal epithelium in vivo. + © 2023. The Author(s). + + + + Liu + Yiping + Y + + School of Marine Science and Engineering, Qingdao Agricultural University, Qingdao, 266109, China. + + + + Ge + Xuefeng + X + + School of Marine Science and Engineering, Qingdao Agricultural University, Qingdao, 266109, China. + + + + Li + Chao + C + + School of Marine Science and Engineering, Qingdao Agricultural University, Qingdao, 266109, China. chaoli@qau.edu.cn. + + + + Xue + Ting + T + + School of Marine Science and Engineering, Qingdao Agricultural University, Qingdao, 266109, China. xueting@qau.edu.cn. + + + + eng + + + 31902403 + National Science Foundation of China + + + + 663-1120029 + Talents Foundation of QAU grant + + + + tsqn201909130 + Young Experts of Taishan Scholars + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + In Vitro Cell Dev Biol Anim + 9418515 + 1071-2690 + + IM + + Cell line + Characterization + Gene expression + Intestine + Turbot + +
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+ + + 36809596 + + 2023 + 02 + 22 + +
+ + 1573-2592 + + + 2023 + Feb + 21 + + + Journal of clinical immunology + J Clin Immunol + + Interferon-α-2b Nasal Spray for Treating SARS-CoV-2 Omicron Variant-Infected Children. + 10.1007/s10875-023-01452-4 + + + Zhou + Jianguo + J + + Department of Neonatology, Children's Hospital of Fudan University, Shanghai, China. + + + + Chen + Xiang + X + + Department of Neonatology, Children's Hospital of Fudan University, Shanghai, China. + + + + Lu + Yanming + Y + + Department of Pediatrics, School of Medicine, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China. + + + + Wang + Libo + L + + Department of Respiratory Disease, Children's Hospital of Fudan University, Shanghai, China. + + + + Yu + Hui + H + http://orcid.org/0000-0003-1342-5537 + + Department of Infectious Diseases, Children's Hospital of Fudan University, Shanghai, China. yuhui4756@sina.com. + + + + eng + + + 2021YFC2701800 + National Key Research and Development Program of China + + + + 2021YFC2701801 + National Key Research and Development Program of China + + + + ZD2021CY001 + Shanghai Municipal Science and Technology Major Project + + + + + Letter + + + 2023 + 02 + 21 + +
+ + Netherlands + J Clin Immunol + 8102137 + 0271-9142 + + IM + + Children + Interferon-α-2b + Nasal spray + SARS-CoV-2 Omicron variant + +
+ + + + 2022 + 06 + 20 + + + 2023 + 02 + 14 + + + 2023 + 2 + 22 + 13 + 57 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809596 + 10.1007/s10875-023-01452-4 + 10.1007/s10875-023-01452-4 + + + + Zhou Q, Chen V, Shannon CP, Wei XS, Xiang X, Wang X, et al. Interferon-α2b treatment for COVID-19. Front Immunol. 2020;11:1061. https://doi.org/10.3389/fimmu.2020.01061 . + + 10.3389/fimmu.2020.01061 + 32574262 + 7242746 + + + + Pandit A, Bhalani N, Bhushan BLS, Koradia P, Gargiya S, Bhomia V, et al. Efficacy and safety of pegylated interferon alfa-2b in moderate COVID-19: a phase II, randomized, controlled, open-label study. Int J Infect Dis IJID Off Publ Int Soc Infect Dis. 2021;105:516–21. https://doi.org/10.1016/j.ijid.2021.03.015 . + + 10.1016/j.ijid.2021.03.015 + + + + Wang N, Zhan Y, Zhu L, Hou Z, Liu F, Song P, et al. Retrospective multicenter cohort study shows early interferon therapy is associated with favorable clinical responses in COVID-19 patients. Cell Host Microbe. 2020;28(3):455-64.e2. https://doi.org/10.1016/j.chom.2020.07.005 . + + 10.1016/j.chom.2020.07.005 + 32707096 + 7368656 + + + + Zhou Q, MacArthur MR, He X, Wei X, Zarin P, Hanna BS, et al. Interferon-α2b treatment for COVID-19 is associated with improvements in lung abnormalities. Viruses. 2020;13(1). https://doi.org/10.3390/v13010044 . + + + Hay JA, Kennedy-Shaffer L, Kanjilal S, Lennon NJ, Gabriel SB, Lipsitch M, et al. Estimating epidemiologic dynamics from cross-sectional viral load distributions. Science. 2021;373(6552). https://doi.org/10.1126/science.abh0635 . + + + +
+ + + 36809594 + + 2023 + 02 + 22 + +
+ + 2193-8245 + + + 2023 + Feb + 21 + + + Ophthalmology and therapy + Ophthalmol Ther + + Safety and Efficacy of Double Lamellar Keratoplasty for Corneal Perforation. + 10.1007/s40123-023-00676-2 + + To assess the outcomes of double lamellar keratoplasty in the treatment of corneal perforation secondary to various keratopathies. + In this prospective non-comparative interventional case series, 15 eyes from 15 consecutive patients with corneal perforation were chosen to undergo double lamellar keratoplasty, which is characterized by two layers of lamellar grafting in the perforated area. The posterior graft was separated from a relatively healthy and thin lamellar graft of the recipient, and the anterior graft was transplanted from the donor lamellar cornea. Preoperative characteristics and postoperative examination and relevant complications throughout the study were recorded. + Nine men and six women with an average age of 50.73 ± 19.89 (range, 9-84) years were enrolled. The median follow-up period was 18 (range, 12-30) months. In all postoperative patients, the integrity of the eyeball was successfully rebuilt, and the anterior chambers were formed without aqueous leakage. At the last visit, best-corrected visual acuity improved in 14/15 patients (93.3%). Slit-lamp microscopy showed that all treated eyes remained fully transparent. Anterior segment optical coherence tomography revealed that the double-layer structure of the treated cornea was clear in the early postoperative stage. In vivo confocal microscopy revealed intact epithelial cells, sub-basal nerves, and clear keratocytes in the transplanted cornea. No immune rejection or recurrence was detected during the follow-up period. + Double lamellar keratoplasty presents a new therapeutic option for patients undergoing corneal perforation, and it provides improvement in visual acuity and reduces the risk of postoperative adverse events. + © 2023. The Author(s). + + + + Cui + Yi + Y + + Department of Ophthalmology, Fujian Medical University Union Hospital, No. 29 Xinquan Road, Gulou District, Fuzhou, 350001, Fujian, China. + + + + Xiao + Xiaoting + X + + Department of Ophthalmology, Fujian Medical University Union Hospital, No. 29 Xinquan Road, Gulou District, Fuzhou, 350001, Fujian, China. + + + + Hu + Jianzhang + J + http://orcid.org/0000-0003-0610-7856 + + Department of Ophthalmology, Fujian Medical University Union Hospital, No. 29 Xinquan Road, Gulou District, Fuzhou, 350001, Fujian, China. ophhjz@163.com. + + + + eng + + + 81870636 + National Natural Science Foundation of China + + + + 2022J01242 + Natural Science Foundation of Fujian Province + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Ophthalmol Ther + 101634502 + + + Case series + Corneal perforation + Double lamellar keratoplasty + Safety and efficacy + +
+ + + + 2022 + 10 + 23 + + + 2023 + 02 + 02 + + + 2023 + 2 + 22 + 13 + 57 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809594 + 10.1007/s40123-023-00676-2 + 10.1007/s40123-023-00676-2 + + + + Kinde B, Vagefi MR, Seitzman GD. Inside-out: infectious endophthalmitis with secondary corneal perforation. Ophthalmology. 2021;128(7):1038. https://doi.org/10.1016/j.ophtha.2021.01.008 . (published online first: epub date). + + 10.1016/j.ophtha.2021.01.008 + 34154723 + + + + Jhanji V, Young AL, Mehta JS, Sharma N, Agarwal T, Vajpayee RB. Management of corneal perforation. Surv Ophthalmol. 2011;56(6):522–38. https://doi.org/10.1016/j.survophthal.2011.06.003 . (published online first: epub date). + + 10.1016/j.survophthal.2011.06.003 + 22117886 + + + + Stamate AC, Tataru CP, Zemba M. Update on surgical management of corneal ulceration and perforation. Rom J Ophthalmol. 2019;63(2):166–73. + + 10.22336/rjo.2019.25 + 31334396 + 6626930 + + + + Chan E, Ayres M. 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+ + + 36809599 + + 2023 + 02 + 22 + +
+ + 1573-7446 + + + 2023 + Feb + 21 + + + Veterinary research communications + Vet Res Commun + + Efficacy of polyvalent vaccine on immune response and disease resistance against streptococcosis/lactococcosis and yersiniosis in rainbow trout (Oncorhynchus mykiss). + 10.1007/s11259-023-10081-6 + + Diseases are the most significant challenge in the development and stability of aquaculture. In this study, the immunogenic efficiency of polyvalent streptococcosis/lactococcosis and yersiniosis vaccines was evaluated by injection and immersion methods in rainbow trout.. The 450 fish with an average weight of 50 ± 5 g were divided into three treatments and three replications as follows: injection vaccine treatment, immersion vaccine treatment and control group without vaccine administration. Fish were kept for 74 days and sampling was done on days 20, 40 and 60. Then, from the 60th to the 74th day, the immunized groups were challenged with three bacteria Streptococcus iniae (S. iniae), Lactococcus garvieae (L. garvieae) and Yersinia ruckeri (Y. ruckeri) separately. A significant difference was observed in the weight gained (WG) in the immunized groups compared to the control group (P < 0.05). The relative survival percentage (RPS) after 14 days of challenge with S. iniae, L. garvieae and Y. ruckeri in the injection group compared to the control group increased respectively (60%, 60% and 70%), (P < 0.05). Also, RPS in the immersion group had an increase respectively (30%, 40% and 50%) after the challenge with S. iniae, L.garvieae and Y. ruckeri compared to the control group. Immune indicators such as antibody titer, complement and lysozyme activity significantly increased in comparison to the control group (P < 0.05). In general, it can be concluded that applying three vaccines by injection and immersion method has significant effects on immune protection and survival rate. However, the injection method is more effective and more suitable than the immersion method. + © 2023. The Author(s), under exclusive licence to Springer Nature B.V. + + + + Erfanmanesh + Ahmad + A + + Animal Biological Product Research Group, Academic Center for Education, Culture and Research (ACECR), Tehran Organization, Tehran, Iran. + + + + Beikzadeh + Babak + B + + Department of Cell and Molecular Biology & Microbiology, Faculty of Biological Sciences and Technology, University of Isfahan, Isfahan, Iran. + + + + Khanzadeh + Majid + M + + Animal Biological Product Research Group, Academic Center for Education, Culture and Research (ACECR), Tehran Organization, Tehran, Iran. khanzade@acecr.ac.ir. + + + Faculty of Fisheries and Environmental Sciences, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran. khanzade@acecr.ac.ir. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Netherlands + Vet Res Commun + 8100520 + 0165-7380 + + IM + + Immune parameters + Rainbow trout + Streptococcosis/Lactococcosis + Vaccine + Yersiniosis + +
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+ + + 36809601 + + 2023 + 02 + 22 + +
+ + 1432-1416 + + 86 + 4 + + 2023 + Feb + 21 + + + Journal of mathematical biology + J Math Biol + + Theoretical growth rate of microalgae under high/low-flashing light. + + 48 + + 10.1007/s00285-023-01871-2 + + Dynamic light regimes strongly impact microalgal photosynthesis efficiency. Finding the optimal way to supply light is then a tricky problem, especially when the growth rate is inhibited by overexposition to light and, at the same time, there is a lack of light in the deepest part of the culture. In this paper, we use the Han model to study the theoretical microalgal growth rate by applying periodically two different light intensities. Two approaches are considered depending on the period of the light pattern. For a large light period, we demonstrate that the average photosynthetic rate can be improved under some conditions. Moreover, we can also enhance the growth rate at steady state as given by the PI-curve. Although, these conditions change through the depth of a bioreactor. This theoretical improvement in the range of 10-15% is due to a recovery of photoinhibited cells during the high irradiance phase. We give a minimal value of the duty cycle for which the optimal irradiance is perceived by the algae culture under flashing light regime. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Fierro Ulloa + J Ignacio + JI + http://orcid.org/0000-0001-5270-0541 + + BIOCORE Project-Team, Inria Sophia Antipolis Méditerranée, Université Nice Côte d'Azur, 2004, Route des Lucioles, BP 93, 06902, Sophia-Antipolis, France. joel-ignacio.fierro-ulloa@inria.fr. + + + + Lu + Liu-Di + LD + + Section de mathématiques, Université de Genève, Rue du Conseil-Général 7-9, 1205, Geneva, Switzerland. + + + + Bernard + Olivier + O + + BIOCORE Project-Team, Inria Sophia Antipolis Méditerranée, Université Nice Côte d'Azur, 2004, Route des Lucioles, BP 93, 06902, Sophia-Antipolis, France. + + + Laboratoire d'Ocèanographie de Villefranche-sur-Mer, Sorbonne Universitè CNRS UMR 7093, Vilefranche-sur-Mer, France. + + + + eng + + + 955520 + Marie Curie + United Kingdom + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + J Math Biol + 7502105 + 0303-6812 + + IM + + Flashing light + Growth rate + Han model + Microalgae + +
+ + + + 2021 + 11 + 19 + + + 2023 + 01 + 11 + + + 2022 + 12 + 13 + + + 2023 + 2 + 22 + 13 + 57 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809601 + 10.1007/s00285-023-01871-2 + 10.1007/s00285-023-01871-2 + + + + Abu-Ghosh S, Fixler D, Dubinsky Z et al (2015) Continuous background light significantly increases flashing-light enhancement of photosynthesis and growth of microalgae. Bioresour Technol 187:144–148 + + 10.1016/j.biortech.2015.03.119 + + + + Abu-Ghosh S, Fixler D, Dubinsky Z et al (2015) Flashing light enhancement of photosynthesis and growth occurs when photochemistry and photoprotection are balanced in dunaliella salina. Eur J Phycol 50(4):469–480. https://doi.org/10.1080/09670262.2015.1069404 + + 10.1080/09670262.2015.1069404 + + + + Abu-Ghosh S, Fixler D, Dubinsky Z et al (2016) Flashing light in microalgae biotechnology. 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+ + + 36809592 + + 2023 + 02 + 22 + +
+ + 1920-7476 + + + 2023 + Feb + 21 + + + Canadian journal of public health = Revue canadienne de sante publique + Can J Public Health + + Mental health and neurocognitive disorder-related hospitalization rates in immigrants and Canadian-born population: a linkage study. + 10.17269/s41997-023-00740-1 + + Mental health and neurocognitive conditions are important causes of hospitalization among immigrants, though patterns may vary by immigrant category, world region of origin, and time since arrival in Canada. This study uses linked administrative data to explore differences in mental health hospitalization rates between immigrants and individuals born in Canada. + Hospital records from the Discharge Abstract Database and the Ontario Mental Health Reporting System for 2011 to 2017 were linked to the 2016 Longitudinal Immigrant Database and to Statistics Canada's 2011 Canadian Census Health and Environment Cohort. Age-standardized hospitalization rates for mental health-related conditions (ASHR-MHs) were derived for immigrants and the Canadian-born population. ASHR-MHs overall and for leading mental health conditions were compared between immigrants and the Canadian-born population, stratified by sex and selected immigration characteristics. Quebec hospitalization data were not available. + Overall, immigrants had lower ASHR-MHs compared to the Canadian-born population. Mood disorders were leading causes of mental health hospitalization for both cohorts. Psychotic, substance-related, and neurocognitive disorders were also leading causes of mental health hospitalization, although there was variation in their relative importance between subgroups. Among immigrants, ASHR-MHs were higher among refugees and lower among economic immigrants, those from East Asia, and those who arrived in Canada most recently. + Differences in hospitalization rates among immigrants from various immigration streams and world regions, particularly for specific types of mental health conditions, highlight the importance of future research that incorporates both inpatient and outpatient mental health services to further understand these relationships. + © 2023. Crown. + + + + Grundy + Anne + A + + Migration Health Branch, Immigration, Refugees and Citizenship Canada, 250 Tremblay Rd, Ottawa, ON, K1G 5P4, Canada. anne.grundy@cic.gc.ca. + + + + Ng + Edward + E + + Health Analysis Division, Statistics Canada, Ottawa, ON, Canada. + + + + Rank + Claudia + C + + Migration Health Branch, Immigration, Refugees and Citizenship Canada, 250 Tremblay Rd, Ottawa, ON, K1G 5P4, Canada. + + + + Quinlan + Jacklyn + J + + Migration Health Branch, Immigration, Refugees and Citizenship Canada, 250 Tremblay Rd, Ottawa, ON, K1G 5P4, Canada. + + + + Giovinazzo + George + G + + Migration Health Branch, Immigration, Refugees and Citizenship Canada, 250 Tremblay Rd, Ottawa, ON, K1G 5P4, Canada. + + + + Viau + Rachel + R + + Migration Health Branch, Immigration, Refugees and Citizenship Canada, 250 Tremblay Rd, Ottawa, ON, K1G 5P4, Canada. + + + + Ponka + David + D + + Department of Family Medicine, University of Ottawa, Ottawa, ON, Canada. + + + + Garner + Rochelle + R + + Health Analysis Division, Statistics Canada, Ottawa, ON, Canada. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Switzerland + Can J Public Health + 0372714 + 0008-4263 + + IM + + RéSUMé: OBJECTIFS: Les problèmes de santé mentale et les troubles neurocognitifs sont des causes importantes d’hospitalisation chez les immigrants, bien que les tendances puissent varier selon la catégorie d’immigrants, la région d’origine mondiale et le temps écoulé depuis l’arrivée au Canada. Cette étude utilise des données administratives couplées afin d’explorer les différences dans les taux d’hospitalisation en santé mentale entre les immigrants et les personnes nées au Canada. MéTHODES: Les dossiers hospitaliers de la Base de données sur les congés des patients et du Système d’information ontarien sur la santé mentale de 2011 à 2017 ont été couplés à la Base de données longitudinales sur l’immigration de 2016 et aux cohortes santé et environnement du Recensement canadien de 2011 de Statistique Canada. Les taux d’hospitalisation normalisés selon l’âge pour les problèmes de santé mentale (THNA-SM) ont été comparés entre les immigrants et la population née au Canada, stratifiés selon le sexe et certaines caractéristiques d’immigration. Les données sur les hospitalisations au Québec n’étaient pas disponibles. RéSULTATS: Dans l’ensemble, les immigrants avaient des THNA-SM plus faibles que la population née au Canada. Les troubles de l’humeur étaient les principales causes d’hospitalisation en santé mentale pour les deux cohortes. Les troubles psychotiques, liés aux substances et neurocognitifs étaient également les principales causes d’hospitalisation en santé mentale, bien que leur importance relative varie entre les sous-groupes. Chez les immigrants, les THNA-SM étaient plus élevés chez les réfugiés et plus faibles chez les immigrants économiques, ceux de l’Asie de l’Est et ceux qui sont arrivés au Canada plus récemment. CONCLUSION: Les différences dans les taux d’hospitalisation chez les immigrants des divers groupes d’immigration et régions du monde, plus particulièrement pour certains types de problèmes de santé mentale, soulignent l’importance de recherches futures qui intègrent les services de santé mentale aux patients hospitalisés ainsi qu’aux patients externes afin de mieux comprendre ces relations. + + + Hospital discharge + Immigrant + Immigration admission category + Mental health + +
+ + + + 2022 + 03 + 22 + + + 2023 + 01 + 05 + + + 2023 + 2 + 22 + 13 + 57 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809592 + 10.17269/s41997-023-00740-1 + 10.17269/s41997-023-00740-1 + + + References + + Abebe, D. S., Lien, L., & Elstad, J. I. (2017). Immigrants’ utilization of specialist mental healthcare according to age, country of origin, and migration history: A nation-wide register study in Norway. Social Psychiatry and Psychiatric Epidemiology, 52(6), 679–687. https://doi.org/10.1007/s00127-017-1381-1 + + 10.1007/s00127-017-1381-1 + 28378064 + + + + Abe-Kim, J., Takeuchi, D. T., Hong, S., Zane, N., Sue, S., Spencer, M. S., Appel, H., Nicdao, E., & Alegría, M. (2007). Use of mental health-related services among immigrant and US-born Asian Americans: Results from the National Latino and Asian American Study. 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+ + + 36809595 + + 2023 + 02 + 22 + +
+ + 2193-8245 + + + 2023 + Feb + 21 + + + Ophthalmology and therapy + Ophthalmol Ther + + Economic Evaluation of Cataract: A Systematic Mapping Review. + 10.1007/s40123-023-00678-0 + + The purpose of this article was to ascertain the existing literature and find the gaps in economic evaluations of cataracts. + Systematic methods were used to search and collect the published literature on economic evaluations of cataracts. A mapping review of studies published in the following bibliographical databases was performed: the National Library of Medicine (PubMed), EMBASE, Web of Science (WOS), and the Central of Reviews and Dissemination (CRD) database. A descriptive analysis was conducted and relevant studies were classified into different groups. + Among 984 studies screened, 56 studies were included in the mapping review. Four research questions were answered. There has been a progressive increase of publications during the last decade. The majority of the included studies were published by authors from institutions in the USA and UK. The most commonly investigated area was cataract surgery followed by intraocular lenses (IOLs). The studies were classified into different categories according to the main outcome evaluated, such as comparisons between different surgical techniques, costs of the cataract surgery, second eye cataract surgery costs, quality of life gain after cataract surgery, waiting time of cataract surgery and costs, and cataract evaluation, follow-up, and costs. In the IOL classification, the most frequently studied area was the comparison between monofocal and multifocal IOLs, followed by the comparison between toric and monofocal IOLs. + Cataract surgery is a cost-effective procedure compared with other non-ophthalmic and ophthalmic interventions and surgery waiting time is an important factor to consider because vision loss has a huge and broad-ranging impact on society. Numerous gaps and inconsistencies are found among the studies included. For this reason, there is a need for further studies according to the classification described in the mapping review. + © 2023. The Author(s). + + + + Ginel + José + J + http://orcid.org/0000-0003-2965-3577 + + Qvision, Department of Ophthalmology, VITHAS Almería Hospital, 04120, Almería, Spain. joseginel@qvision.es. + + + + Burguera + Noemi + N + http://orcid.org/0000-0002-3735-6452 + + Qvision, Department of Ophthalmology, VITHAS Almería Hospital, 04120, Almería, Spain. + + + + Rocha-de-Lossada + Carlos + C + http://orcid.org/0000-0001-7464-2493 + + Qvision, Department of Ophthalmology, VITHAS Almería Hospital, 04120, Almería, Spain. + + + Department of Ophthalmology, VITHAS Málaga, 29016, Málaga, Spain. + + + Department of Ophthalmology, Regional University Hospital of Málaga, Plaza del Hospital Civil, S/N. 29009, Málaga, Spain. + + + Department of Surgery, Ophthalmology, University of Sevilla, Doctor Fedriani, S/N, 41009, Seville, Spain. + + + + Piñero + David + D + http://orcid.org/0000-0002-1546-4807 + + Department of Optics, Pharmacology and Anatomy, University of Alicante, Alicante, Spain. + + + Department of Ophthalmology (IMQO-Oftalmar), Vithas Medimar International Hospital, Alicante, Spain. + + + + Sáez-Martín + Alejandro + A + + Department of Economics and Business, Faculty of Economics and Business Studies, University of Almería, Ctra. Sacramento S/N, La Cañada de San Urbano, 04120, Almería, Spain. + + + + Fernández + Joaquín + J + http://orcid.org/0000-0002-4626-3741 + + Qvision, Department of Ophthalmology, VITHAS Almería Hospital, 04120, Almería, Spain. + + + + eng + + Journal Article + Review + + + 2023 + 02 + 21 + +
+ + England + Ophthalmol Ther + 101634502 + + + And cost–utility analysis + Cataract + Cost-effectiveness analysis + +
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+ + 1573-7446 + + + 2023 + Feb + 21 + + + Veterinary research communications + Vet Res Commun + + Hexanic extract of Achyrocline satureioides: antimicrobial activity and in vitro inhibitory effect on mechanisms related to the pathogenicity of Paenibacillus larvae. + 10.1007/s11259-023-10086-1 + + Paenibacillus larvae is a spore-forming bacillus, the most important bacterial pathogen of honeybee larvae and the causative agent of American foulbrood (AFB). Control measures are limited and represent a challenge for both beekeepers and researchers. For this reason, many studies focus on the search for alternative treatments based on natural products. + The objective of this study was to determine the antimicrobial activity of the hexanic extract (HE) of Achyrocline satureioides on P. larvae and the inhibitory activity on some mechanisms related to pathogenicity. + The Minimum Inhibitory Concentration (MIC) of the HE was determined by the broth microdilution technique and the Minimum Bactericidal Concentration (MBC) by the microdrop technique. Swimming and swarming motility was evaluated in plates with 0.3 and 0.5% agar, respectively. Biofilm formation was evaluated and quantified by the Congo red and crystal violet method. The protease activity was evaluated by the qualitative technique on skim milk agar plates. + It was determined that the MIC of the HE on four strains of P. larvae ranged between 0.3 and 9.37 µg/ml and the MBC between 1.17 and 150 µg/ml. On the other hand, sub-inhibitory concentrations of the HE were able to decrease swimming motility, biofilm formation and the proteases production of P. larvae. + © 2023. The Author(s), under exclusive licence to Springer Nature B.V. + + + + Paletti Rovey + María Fernanda + MF + http://orcid.org/0000-0002-6127-9733 + + Departamento de Microbiología e Inmunología, Facultad de Ciencias Exactas, Fisico-Químicas y Naturales, Instituto de Biotecnología Ambiental y Salud (INBIAS), Universidad Nacional de Río Cuarto, Ruta Nacional 36 - Km. 601, X5804BYA, Río Cuarto, Córdoba, Argentina. mpalettirovey@exa.unrc.edu.ar. + + + CONICET (Consejo Nacional de Investigaciones Científicas y Técnicas), 2290, C1425FQB CABA, Godoy Cruz, Buenos Aires, Argentina. mpalettirovey@exa.unrc.edu.ar. + + + + Sotelo + Jesica Paola + JP + http://orcid.org/0000-0003-3106-4552 + + Departamento de Microbiología e Inmunología, Facultad de Ciencias Exactas, Fisico-Químicas y Naturales, Instituto de Biotecnología Ambiental y Salud (INBIAS), Universidad Nacional de Río Cuarto, Ruta Nacional 36 - Km. 601, X5804BYA, Río Cuarto, Córdoba, Argentina. + + + CONICET (Consejo Nacional de Investigaciones Científicas y Técnicas), 2290, C1425FQB CABA, Godoy Cruz, Buenos Aires, Argentina. + + + + Carezzano + María Evangelina + ME + http://orcid.org/0000-0002-3442-996X + + Departamento de Microbiología e Inmunología, Facultad de Ciencias Exactas, Fisico-Químicas y Naturales, Instituto de Biotecnología Ambiental y Salud (INBIAS), Universidad Nacional de Río Cuarto, Ruta Nacional 36 - Km. 601, X5804BYA, Río Cuarto, Córdoba, Argentina. + + + CONICET (Consejo Nacional de Investigaciones Científicas y Técnicas), 2290, C1425FQB CABA, Godoy Cruz, Buenos Aires, Argentina. + + + + Huallpa + Carlos + C + http://orcid.org/0000-0002-7778-0880 + + Departamento de Microbiología e Inmunología, Facultad de Ciencias Exactas, Fisico-Químicas y Naturales, Instituto de Biotecnología Ambiental y Salud (INBIAS), Universidad Nacional de Río Cuarto, Ruta Nacional 36 - Km. 601, X5804BYA, Río Cuarto, Córdoba, Argentina. + + + CONICET (Consejo Nacional de Investigaciones Científicas y Técnicas), 2290, C1425FQB CABA, Godoy Cruz, Buenos Aires, Argentina. + + + + Oliva + María de Las Mercedes + MLM + http://orcid.org/0000-0001-6159-762X + + Departamento de Microbiología e Inmunología, Facultad de Ciencias Exactas, Fisico-Químicas y Naturales, Instituto de Biotecnología Ambiental y Salud (INBIAS), Universidad Nacional de Río Cuarto, Ruta Nacional 36 - Km. 601, X5804BYA, Río Cuarto, Córdoba, Argentina. + + + CONICET (Consejo Nacional de Investigaciones Científicas y Técnicas), 2290, C1425FQB CABA, Godoy Cruz, Buenos Aires, Argentina. + + + + eng + + + Res. 083/20 + Fondo para la Investigación Científica y Tecnológica + + + + Res. 083/20 + Fondo para la Investigación Científica y Tecnológica + + + + Res. 083/20 + Fondo para la Investigación Científica y Tecnológica + + + + Res. 083/20 + Fondo para la Investigación Científica y Tecnológica + + + + Res. 083/20 + Fondo para la Investigación Científica y Tecnológica + + + + + Journal Article + + + 2023 + 02 + 21 + +
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+ + + 36809604 + + 2023 + 02 + 22 + +
+ + 1573-7373 + + + 2023 + Feb + 21 + + + Journal of neuro-oncology + J Neurooncol + + Inhibition of the epigenetically activated miR-483-5p/IGF-2 pathway results in rapid loss of meningioma tumor cell viability. + 10.1007/s11060-023-04264-z + + Meningioma is the most common primary central nervous system tumor often causing serious complications, and presently no medical treatment is available. The goal of this study was to discover miRNAs dysregulated in meningioma, and explore miRNA-associated pathways amenable for therapeutic interventions. + Small RNA sequencing was performed on meningioma tumor samples to study grade-dependent changes in microRNA expression. Gene expression was analyzed by chromatin marks, qRT-PCR and western blot. miRNA modulation, anti-IGF-2 neutralizing antibodies, and inhibitors against IGF1R were evaluated in a tumor-derived primary cultures of meningioma cells. + Meningioma tumor samples showed high, grade-dependent expression of miR-483-5p, associated with high mRNA and protein expression of its host gene IGF-2. Inhibition of miR-483-5p reduced the growth of cultured meningioma cells, whereas a miR-483 mimic increased cell proliferation. Similarly, inhibition of this pathway with anti-IGF-2 neutralizing antibodies reduced meningioma cell proliferation. Small molecule tyrosine kinase inhibitor blockade of the IGF-2 receptor (IGF1R) resulted in rapid loss of viability of cultured meningioma tumor-derived cells, suggesting that autocrine IGF-2 feedback is obligatory for meningioma tumor cell survival and growth. The observed IGF1R-inhibitory IC50 for GSK1838705A and ceritinib in cell-based assays along with the available pharmacokinetics data predicted that effective drug concentration could be achieved in vivo as a new medical treatment of meningioma. + Meningioma cell growth is critically dependent on autocrine miR-483/IGF-2 stimulation and the IGF-2 pathway provides a feasible meningioma treatment target. + © 2023. The Author(s). + + + + Uhlmann + Erik J + EJ + + Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA, 02215, USA. euhlmann@bidmc.harvard.edu. + + + + Mackel + Charles E + CE + + Department of Neurosurgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 110 Francis Street, Boston, MA, 02215, USA. + + + + Deforzh + Evgeny + E + + Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA. + + + + Rabinovsky + Rosalia + R + + Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA. + + + + Brastianos + Priscilla K + PK + + Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA. + + + + Varma + Hemant + H + + Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA, 02215, USA. + + + + Vega + Rafael A + RA + + Department of Neurosurgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 110 Francis Street, Boston, MA, 02215, USA. + + + + Krichevsky + Anna M + AM + + Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA. + + + + eng + + + R01CA215072 + National Institutes of Health + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + J Neurooncol + 8309335 + 0167-594X + + IM + + Ceritinib + IGF-2 + IGF1R + Meningioma + miR-483-5p + +
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Lancet 389(10072):917–929. https://doi.org/10.1016/S0140-6736(17)30123-X + + 10.1016/S0140-6736(17)30123-X + 28126333 + + + + Sabbatini P, Korenchuk S, Rowand JL et al (2009) GSK1838705A inhibits the insulin-like growth factor-1 receptor and anaplastic lymphoma kinase and shows antitumor activity in experimental models of human cancers. Mol Cancer Ther 8(10):2811–2820. https://doi.org/10.1158/1535-7163.MCT-09-0423 https://doi.org/10.1016/j.jtocrr.2021.100206 + + 10.1158/1535-7163.MCT-09-0423 + 19825801 + + + + Park K, Tan DSW, Su WC et al (2021) Phase 1b open-label trial of Afatinib Plus Xentuzumab (BI 836845) in patients with EGFR mutation-positive NSCLC after Progression on EGFR tyrosine kinase inhibitors. JTO Clin Res Rep 2(9):100206. https://doi.org/10.1016/j.jtocrr.2021.100206 + + 10.1016/j.jtocrr.2021.100206 + 34590052 + 8474216 + + + + Ma Y, Han CC, Li Y, Wang Y et al (2016) Insulin-like growth factor-binding protein-3 inhibits IGF-1-induced proliferation of human hepatocellular carcinoma cells by controlling bFGF and PDGF autocrine/paracrine loops. Biochem Biophys Res Commun 478(2):964-9 https://doi.org/10.1016/j.bbrc.2016.08.059 . Epub 2016 Aug 10. PMID: 27521890. + + + +
+ + + 36809606 + + 2023 + 02 + 22 + +
+ + 1534-4681 + + + 2023 + Feb + 21 + + + Annals of surgical oncology + Ann Surg Oncol + + ASO Visual Abstract: The Absence of Cancer in the Location of a Breast Tissue Marker After Neoadjuvant Chemotherapy May Predict Pathological Complete Response with High Accuracy-Results from a Phase II Trial. + 10.1245/s10434-023-13245-5 + + + Kataoka + Ayumi + A + + Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya, Japan. + + + + Sawaki + Masataka + M + http://orcid.org/0000-0002-2927-9258 + + Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya, Japan. m-sawaki@aichi-cc.jp. + + + + Horisawa + Nanae + N + + Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya, Japan. + + + + Kotani + Haruru + H + + Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya, Japan. + + + + Yoshimura + Akiyo + A + + Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya, Japan. + + + + Hattori + Masaya + M + + Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya, Japan. + + + + Adachi + Yayoi + Y + + Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya, Japan. + + + + Sugino + Kayoko + K + + Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya, Japan. + + + + Endo + Yuka + Y + + Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya, Japan. + + + + Ozaki + Yuri + Y + + Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya, Japan. + + + + Sasaki + Eiichi + E + + Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya, Japan. + + + + Hosoda + Waki + W + + Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya, Japan. + + + + Iwata + Hiroji + H + + Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya, Japan. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Ann Surg Oncol + 9420840 + 1068-9265 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 57 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809606 + 10.1245/s10434-023-13245-5 + 10.1245/s10434-023-13245-5 + + +
+ + + 36809605 + + 2023 + 02 + 22 + +
+ + 1534-4681 + + + 2023 + Feb + 21 + + + Annals of surgical oncology + Ann Surg Oncol + + ASO Visual Abstract: Robot-Assisted Versus Laparoscopic Distal Pancreatectomy in Patients with Resectable Pancreatic Cancer-An International Retrospective Cohort Study. + 10.1245/s10434-023-13161-8 + + + Chen + Jeffrey W + JW + + Amsterdam UMC, Department of Surgery, Location University of Amsterdam, Amsterdam, The Netherlands. + + + Cancer Center Amsterdam, Amsterdam, The Netherlands. + + + + van Ramshorst + Tess M E + TME + + Amsterdam UMC, Department of Surgery, Location University of Amsterdam, Amsterdam, The Netherlands. t.vanramshorst@amsterdamumc.nl. + + + Cancer Center Amsterdam, Amsterdam, The Netherlands. t.vanramshorst@amsterdamumc.nl. + + + Department of General Surgery, Istituto Ospedaliero Fondazione Poliambulanza, Brescia, Italy. t.vanramshorst@amsterdamumc.nl. + + + + Lof + Sanne + S + + Amsterdam UMC, Department of Surgery, Location University of Amsterdam, Amsterdam, The Netherlands. + + + Cancer Center Amsterdam, Amsterdam, The Netherlands. + + + + Al-Sarireh + Bilal + B + + Department of Surgery, Morriston Hospital, Swansea, United Kingdom. + + + + Bjornsson + Bergthor + B + + Department of Surgery and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden. + + + + Boggi + Ugo + U + + Department of Surgery, University Hospital of Pisa, Pisa, Italy. + + + + Burdio + Fernando + F + + Department of Surgery, University Hospital del Mar, Barcelona, Spain. + + + + Butturini + Giovanni + G + + Department of Surgery, Pederzoli Hospital, Peschiera, Italy. + + + + Casadei + Riccardo + R + + Department of Surgery, Sant'Orsola Malphigi Hospital, Bologna, Italy. + + + + Coratti + Andrea + A + + Division of Oncological and Robotic General Surgery, Careggi University Hospital, Florence, Italy. + + + + D'Hondt + Mathieu + M + + Department of Digestive and Hepatobiliary/Pancreatic Surgery, Groeninge Hospital, Kortrijk, Belgium. + + + + Dokmak + Safi + S + + Department of HPB Surgery and Liver Transplantation, Beaujon Hospital, Clichy, France. + + + + Edwin + Bjørn + B + + The Intervention Center, Department of Surgery, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway. + + + + Esposito + Alessandro + A + + Department of General and Pancreatic Surgery, Pancreas Institute, Verona University Hospital, Verona, Italy. + + + + Fabre + Jean M + JM + + Department of Surgery, Saint-Éloi Hospital, Montpellier, France. + + + + Ferrari + Giovanni + G + + Department of Surgery, Niguarda Hospital, Milan, Italy. + + + + Ftériche + Fadhel S + FS + + Department of HPB Surgery and Liver Transplantation, Beaujon Hospital, Clichy, France. + + + + Fusai + Giuseppe K + GK + + HPB & Liver Transplant Unit, Royal Free London, London, United Kingdom. + + + + Koerkamp + Bas Groot + BG + + Department of Surgery, Erasmus MC Cancer Institute, Rotterdam, The Netherlands. + + + + Hackert + Thilo + T + + Department of Surgery, Heidelberg University Hospital, Heidelberg, Germany. + + + + Jah + Asif + A + + Department of HPB Surgery and Transplantation, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom. + + + + Jang + Jin-Young + JY + + Department of Surgery, Seoul National University Hospital, Seoul, South Korea. + + + + Kauffmann + Emanuele F + EF + + Department of Surgery, University Hospital of Pisa, Pisa, Italy. + + + + Keck + Tobias + T + + Department of Surgery, University Medical Center Schleswig-Holstein, Campus Lübeck, Lübeck, Germany. + + + + Manzoni + Alberto + A + + Department of General Surgery, Istituto Ospedaliero Fondazione Poliambulanza, Brescia, Italy. + + + + Marino + Marco V + MV + + Department of Emergency and General Surgery, Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy. + + + + Molenaar + Quintus + Q + + Department of Surgery, UMC Utrecht Cancer Center, University Medical Center Utrecht, Utrecht, The Netherlands. + + + + Rau + Elizabeth Pando + EP + + Department of Surgery, Vall d'Hebron University Hospital, Barcelona, Spain. + + + + Pessaux + Patrick + P + + Department of Hepato-Biliary and Pancreatic Surgery, Nouvel Hôpital Civil, Institut Hospitalo-Universitaire de Strasbourg, Strasbourg, France. + + + + Pietrabissa + Andrea + A + + Department of Surgery, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. + + + + Soonawalla + Zahir + Z + + Department of Surgery, Oxford University Hospital, Oxford, UK. + + + + Sutcliffe + Robert P + RP + + Department of Hepato-Pancreato-Biliary and Liver Transplant Surgery, Queen Elizabeth University Hospitals Birmingham, Birmingham, UK. + + + + Timmermann + Lea + L + + Department of Surgery, Charité, Berlin, Germany. + + + + White + Steven + S + + Department of Surgery, The Freeman Hospital, Newcastle Upon Tyne, Newcastle, UK. + + + + Yip + Vincent S + VS + + Department of HPB Surgery, The Royal London Hospital, Bartshealth NHS Trust, London, UK. + + + + Zerbi + Alessandro + A + + Department of Surgery, Humanitas University and IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy. + + + + Hilal + Mohammad Abu + MA + + Department of General Surgery, Istituto Ospedaliero Fondazione Poliambulanza, Brescia, Italy. + + + + Besselink + Marc G + MG + + Amsterdam UMC, Department of Surgery, Location University of Amsterdam, Amsterdam, The Netherlands. + + + Cancer Center Amsterdam, Amsterdam, The Netherlands. + + + + European Consortium on Minimally Invasive Pancreatic Surgery (E-MIPS) + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Ann Surg Oncol + 9420840 + 1068-9265 + + IM + + + Aussilhou + Beatrice + B + + + Kamarajah + Sivesh K + SK + + + van Laarhoven + Stijn + S + + + Malinka + Thomas + T + + + Marudanayagam + Ravi + R + + + Ricci + Claudio + C + + + Sánchez-Velázquez + Patricia + P + + +
+ + + + 2023 + 2 + 22 + 13 + 57 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809605 + 10.1245/s10434-023-13161-8 + 10.1245/s10434-023-13161-8 + + +
+ + + 36809609 + + 2023 + 02 + 22 + +
+ + 1534-4681 + + + 2023 + Feb + 21 + + + Annals of surgical oncology + Ann Surg Oncol + + ASO Visual Abstract: Validation of a Resectability Scoring System for Prediction of Pancreatic Adenocarcinoma Surgical Outcomes. + 10.1245/s10434-023-13243-7 + + + Toesca + Diego A S + DAS + http://orcid.org/0000-0003-3012-7021 + + Department of Radiation Oncology, Mayo Clinic Arizona, Phoenix, AZ, USA. santostoesca.diegoaugusto@mayo.edu. + + + + Chang + Daniel T + DT + + Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Ann Surg Oncol + 9420840 + 1068-9265 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 57 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809609 + 10.1245/s10434-023-13243-7 + 10.1245/s10434-023-13243-7 + + +
+ + + 36809602 + + 2023 + 02 + 22 + +
+ + 2589-0409 + + 35 + 1 + + 2023 + Feb + 21 + + + Journal of the Egyptian National Cancer Institute + J Egypt Natl Canc Inst + + The incidence and trends of laryngeal malignancies in Sri Lanka from 2001 to 2019: a Joinpoint analysis of the national cancer database. + + 3 + + 10.1186/s43046-023-00163-6 + + Laryngeal cancer is the ninth commonest cancer among Asian males. Global and regional epidemiological analyses have shown varying patterns in the incidence and risk factors for laryngeal cancer. Therefore, we aimed to analyse the trends in the incidence and histological patterns of laryngeal cancers for the first time in Sri Lanka. + We used the population-based Sri Lanka cancer registry data and pooled all newly diagnosed patients with laryngeal malignancies from 2001 to 2019 (a 19-year study period). The WHO age-standardised incidence rates (ASR) were calculated using the WHO standard pollution. We used the Joinpoint regression software to calculate the estimated annual percentage change (EAPC) and analysed the trends in the incidence by different age categories and sex. + From 2001 to 2019, 9808 new cases of laryngeal cancers (males = 8927, 91%, mean age = 62 years) were registered. The incidence of laryngeal cancers was greatest in the 70-74-year followed by 65-69-year age groups. Around 7.9% were reported as carcinoma not otherwise specified (NOS). Squamous cell carcinoma (90.1%) was the commonest documented histology type. A rise in the WHO-ASR was noted from 1.91 per 100,000 in 2001 [95% confidence interval (95% CI): 1.69-2.12] to 3.59 per 100,000 in 2017 [(95% CI: 3.34-3.84); EAPC: 4.4 (95% CI: 3.7-5.2), p < 0.05 for trend] followed by a decrease in the incidence [2.97 per 100,000 in 2019 (95% CI: 2.74-3.2), EAPC: - 7.2 (95% CI: - 21.1-9.1, p > 0.05)]. From 2001 to 2017, the proportional increase in incidence was greater in males than females [EAPC: 4.9 (95% CI: 4.1-5.7 vs. 3.7 (95% CI: 1.7-5.6)]. + We identified an increasing incidence of laryngeal cancer in Sri Lanka from 2001 to 2017 followed by a slight decrease. Further studies are essential to identify the aetiological factors. Development of laryngeal cancer prevention and screening programmes for high-risk populations may be considered. + © 2023. The Author(s). + + + + Jayarajah + Umesh + U + http://orcid.org/0000-0002-0398-5197 + + Department of Surgery, Faculty of Medicine, University of Colombo, Kynsey Road, , P.O. Box 271, Colombo 8, Western Province, Sri Lanka. umeshe.jaya@gmail.com. + + + + Jayasinghe + Ravindri + R + + Department of Surgery, Faculty of Medicine, University of Colombo, Kynsey Road, , P.O. Box 271, Colombo 8, Western Province, Sri Lanka. + + + + Fernando + Ashan + A + + Department of Surgery, Faculty of Medicine, University of Colombo, Kynsey Road, , P.O. Box 271, Colombo 8, Western Province, Sri Lanka. + + + + Seneviratne + Sanjeewa + S + + Department of Surgery, Faculty of Medicine, University of Colombo, Kynsey Road, , P.O. Box 271, Colombo 8, Western Province, Sri Lanka. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + J Egypt Natl Canc Inst + 9424566 + 1110-0362 + + IM + + Age-standardised rate + Incidence + Laryngeal cancer + National cancer registry + Sri Lanka + +
+ + + + 2022 + 03 + 07 + + + 2023 + 02 + 13 + + + 2023 + 2 + 22 + 13 + 57 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809602 + 10.1186/s43046-023-00163-6 + 10.1186/s43046-023-00163-6 + + + + World Health Organization. Cancer Today - GLOBOCAN. 2020.  https://gco.iarc.fr/today/home . (Accessed 25 Mar 2022). + + + Nocini R, Molteni G, Mattiuzzi C, Lippi G. Updates on larynx cancer epidemiology. Chin J Cancer Res. 2020;32(1):18–25. + + 10.21147/j.issn.1000-9604.2020.01.03 + 32194301 + 7072014 + + + + Bobdey S, Jain A, Balasubramanium G. Epidemiological review of laryngeal cancer: an Indian perspective. Indian J Med Paediatr Oncol. 2015;36(3):154–60. + + 10.4103/0971-5851.166721 + 26855523 + 4743184 + + + + Deng Y, Wang M, Zhou L, Zheng Y, Li N, Tian T, Zhai Z, Yang S, Hao Q, Wu Y, Song D, Zhang D, Lyu J, Dai Z. Global burden of larynx cancer, 1990–2017: estimates from the global burden of disease 2017 study. Aging (Albany NY). 2020;12(3):2545–83. + + 10.18632/aging.102762 + 32035421 + + + + National Cancer Control Programme Sri Lanka. Cancer incidence data. 2022.  http://www.nccp.health.gov.lk/index.php/publications/cancer-registries . (Accessed Jan 2022). + + + Gunasekera S, Seneviratne S, Wijeratne T, Booth CM. Delivery of cancer care in Sri Lanka. J Cancer Policy. 2018;18:20–4. + + 10.1016/j.jcpo.2018.10.001 + + + + Ahmad OB, Boschi-Pinto C, Lopez AD, Murray CJ, Lozano R, Inoue M. Age standardization of rates: a new WHO standard. Geneva: World Health Organization 9; 2001. + + + Jayarajah U, Udayanga V, Fernando A, Samarasekera DN, Seneviratne S. The incidence and histological patterns of colorectal cancer in Sri Lanka from 2001 to 2010: analysis of national cancer registry data. Eur J Cancer Care. 2020. https://doi.org/10.1111/ecc.13247 . + + + Jayarajah U, Almeida I, Fernando A, Samarasekera D, Seneviratne S, Incidence and age-standardized rates of pancreatic cancer in Sri Lanka from,. to 2010: an analysis of national cancer registry data. Indian J Cancer. 2001;2020:57. https://doi.org/10.4103/ijc.IJC_238_19 . + + 10.4103/ijc.IJC_238_19 + + + + Joinpoint Regression Program V. Statistical methodology and applications branch. In: Surveillance Research Program. USA: National Cancer Institut; 2017. + + + Jayarajah U, Arulanantham A, Fernando A, Ilangamge S, Seneviratne S. The incidence and patterns of lung cancer in Sri Lanka from 2001 to 2010: analysis of national cancer registry data. Eur J Cancer Care. 2020. https://doi.org/10.1111/ecc.13354 . + + + Kim H-J, Fay MP, Feuer EJ, Midthune DN. Permutation tests for joinpoint regression with applications to cancer rates. Stat Med. 2000;19(3):335–51. + + 10.1002/(SICI)1097-0258(20000215)19:3<335::AID-SIM336>3.0.CO;2-Z + 10649300 + + + + Gupta B, Johnson NW, Kumar N. Global epidemiology of head and neck cancers: a continuing challenge. Oncology. 2016;91(1):13–23. + + 10.1159/000446117 + 27245686 + + + + Mishra A, Meherotra R. Head and neck cancer: global burden and regional trends in India. Asian Pac J Cancer Prev. 2014;15(2):537–50. + + 10.7314/APJCP.2014.15.2.537 + 24568456 + + + + Jayarajah U, Abeygunasekera AM. Cancer services in Sri Lanka: current status and future directions. J Egypt Natl Canc Inst. 2021;33:13. https://doi.org/10.1186/s43046-021-00070-8 . + + 10.1186/s43046-021-00070-8 + 34081229 + + + + Sharma MK, Gour N, Pandey A, Wallia D. Epidemiological study of risk factors for oral, laryngeal and esophageal cancers at a tertiary care hospital in India. Asian Pac J Cancer Prev. 2011;12(5):1215–8. + + 21875270 + + + + UpToDate, Epidemiology and risk factors for head and neck cancer, 2018. https://www.uptodate.com/contents/epidemiology-and-risk-factors-for-head-and-neck-cancer . (Accessed Jan 2022). + + + Katulanda P, Wickramasinghe K, Mahesh J, Rathnapala A, Constantine G, Sheriff MHR, Matthews D, Fernando S. Prevalence and correlates of tobacco smoking in Sri Lanka. Asia Pac J Public Health. 2010;23:861–9 Asia-Pacific Academic Consortium for Public Health. + + 10.1177/1010539509355599 + 20460291 + + + + WHO. Global alcohol report Sri Lanka. 2016. https://www.who.int/substance_abuse/publications/global_alcohol_report/profiles/lka.pdf?ua=1 . (Accessed Jan 2022). + + + Epidemiology Unit. HPV vaccination report. 2018.  http://www.epid.gov.lk/web/images/pdf/HPV/hpv_vaccination_expert_comitee_and_rec.pdf . (Accessed Jan 2022). + + + +
+ + + 36809610 + + 2023 + 02 + 22 + +
+ + 1614-7499 + + + 2023 + Feb + 21 + + + Environmental science and pollution research international + Environ Sci Pollut Res Int + + Identification and ranking of enablers to green technology adoption for manufacturing firms using an ISM-MICMAC approach. + 10.1007/s11356-023-25744-9 + + The debate about the adoption of green technologies (GTs) is trending due to increasing environmental concerns across the globe. In the context of the manufacturing industry, the research about enablers to GT adoption while using the ISM-MICMAC approach is scarce. Hence, the empirical analysis of GT enablers is being done in this study using a novel ISM-MICMAC method. Firstly, the research framework is developed by using the ISM-MICMAC methodology. Then, enablers to GTs were extracted from existing studies and validated by experts. Results showed that the most significant enabler to GT adoption is providing incentives for green manufacturers (1) in the ISM model. So, manufacturing firms must take initiatives for GTs to mitigate the negative environmental impact of industrialization without losing their earnings. This research brings substantial empirical scholarship to understand GT enablers and their contribution in GT enabler incorporation in the manufacturing industry of developing economies. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Usmani + Muhammad Shahjahan + MS + + School of Management, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China. + + + + Wang + Jianling + J + + School of Management, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China. + + + + Waqas + Muhammad + M + http://orcid.org/0000-0001-6151-8864 + + School of Management, Jiangsu University, Zhenjiang, 212013, China. mwaqas@gudgk.edu.pk. + + + Department of Business Administration, Ghazi University, Dera Ghazi Khan, Punjab, Pakistan. mwaqas@gudgk.edu.pk. + + + + Iqbal + Muzaffar + M + + College of Management and Economics, Tianjin University, Tianjin, People's Republic of China. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Environ Sci Pollut Res Int + 9441769 + 0944-1344 + + IM + + Emerging countries + Enablers + Green technology + ISM-MICMAC + Manufacturing sector + +
+ + + + 2022 + 11 + 03 + + + 2023 + 02 + 01 + + + 2023 + 2 + 22 + 13 + 57 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809610 + 10.1007/s11356-023-25744-9 + 10.1007/s11356-023-25744-9 + + + + Ahmad N, Zhu Y, Hongli L, Karamat J, Waqas M, Taskheer Mumtaz SM (2020) Mapping the obstacles to brownfield redevelopment adoption in developing economies: Pakistani perspective. Land Use Policy 91:104374 + + 10.1016/j.landusepol.2019.104374 + + + + Alawamleh M, Popplewell K (2011) Interpretive structural modelling of risk sources in a virtual organisation. Int J Prod Res 49:6041–6063 + + 10.1080/00207543.2010.519735 + + + + Alola AA, Adebayo TS (2022) Are green resource productivity and environmental technologies the face of environmental sustainability in the Nordic region? Sustain Dev 1–13. https://doi.org/10.1002/sd.2417 + + + Arrow KJ, Cohen L, David PA et al (2009) A statement on the appropriate role for research and development in climate policy, p 6. https://doi.org/10.2202/1553-3832.1518 + + + Attri R, Dev N, Sharma V (2013) Interpretive structural modelling (ISM) approach: an overview. Res J Manag Sci 2319:1171 + + + Bank W (2007) Cost of pollution in China. World Bank, Washington DC + + + Bian J, Zhang G, Zhou G (2020) Manufacturer vs. consumer subsidy with green technology investment and environmental concern. Eur J Oper Res 287:832–843. https://doi.org/10.1016/j.ejor.2020.05.014 + + 10.1016/j.ejor.2020.05.014 + + + + Brunnermeier SB, Cohen MA (2003) Determinants of environmental innovation in US manufacturing industries. 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+ + 1614-7499 + + + 2023 + Feb + 21 + + + Environmental science and pollution research international + Environ Sci Pollut Res Int + + Copper toxicity leads to accumulation of free amino acids and polyphenols in Phaeodactylum tricornutum diatoms. + 10.1007/s11356-023-25939-0 + + This work is focused on the effect of lethal and sub-lethal copper (Cu) concentrations on the free amino acid and polyphenol production by the marine diatom Phaeodactylum tricornutum (P. tricornutum) after 12, 18, and 21 days of exposure. The concentrations of 10 amino acids (arginine, aspartic acid, glutamic acid, histidine, lysine, methionine, proline, valine, isoleucine, and phenylalanine) and 10 polyphenols (gallic acid, protocatechuic acid, p-coumaric acid, ferulic acid, catechin, vanillic acid, epicatechin syringic acid, rutin, and gentisic acid) were measured by RP-HPLC. Under lethal doses of Cu, free amino acids reached levels significantly higher than those in the control cells (up to 21.9 times higher), where histidine and methionine showed the highest increases (up to 37.4 and 65.8 times higher, respectively). The total phenolic content also increased up to 11.3 and 5.59 times higher compared to the reference cells, showing gallic acid the highest increase (45.8 times greater). The antioxidant activities of cells exposed to Cu were also enhanced with increasing doses of Cu(II). They were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging ability (RSA), cupric ion reducing antioxidant capacity (CUPRAC), and ferric reducing antioxidant power (FRAP) assays. Malonaldehyde (MDA) exhibited the same tendency: cells grown at the highest lethal Cu concentration yielded the highest MDA level. These findings reflect the involvement of amino acids and polyphenols in protective mechanisms to overcome the toxicity of copper in marine microalgae. + © 2023. The Author(s). + + + + Santiago-Díaz + Paula + P + + Departamento de Química, Facultad de Ciencias del Mar, Universidad de Las Palmas de Gran Canaria, Campus de Tafira, 35017, Las Palmas de Gran Canaria, Spain. + + + Instituto de Oceanografía Y Cambio Global (IOCAG), Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain. + + + + Rivero + Argimiro + A + + Departamento de Química, Facultad de Ciencias del Mar, Universidad de Las Palmas de Gran Canaria, Campus de Tafira, 35017, Las Palmas de Gran Canaria, Spain. + + + Instituto de Oceanografía Y Cambio Global (IOCAG), Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain. + + + + Rico + Milagros + M + http://orcid.org/0000-0002-2711-8952 + + Departamento de Química, Facultad de Ciencias del Mar, Universidad de Las Palmas de Gran Canaria, Campus de Tafira, 35017, Las Palmas de Gran Canaria, Spain. milagros.ricosantos@ulpgc.es. + + + Instituto de Oceanografía Y Cambio Global (IOCAG), Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain. milagros.ricosantos@ulpgc.es. + + + + González González + Aridane + A + + Departamento de Química, Facultad de Ciencias del Mar, Universidad de Las Palmas de Gran Canaria, Campus de Tafira, 35017, Las Palmas de Gran Canaria, Spain. + + + Instituto de Oceanografía Y Cambio Global (IOCAG), Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain. + + + + González-Dávila + Melchor + M + + Departamento de Química, Facultad de Ciencias del Mar, Universidad de Las Palmas de Gran Canaria, Campus de Tafira, 35017, Las Palmas de Gran Canaria, Spain. + + + Instituto de Oceanografía Y Cambio Global (IOCAG), Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain. + + + + Santana-Casiano + Magdalena + M + + Departamento de Química, Facultad de Ciencias del Mar, Universidad de Las Palmas de Gran Canaria, Campus de Tafira, 35017, Las Palmas de Gran Canaria, Spain. + + + Instituto de Oceanografía Y Cambio Global (IOCAG), Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain. + + + + eng + + + CTM2017-83476-P + Ministerio de Economía, Industria y Competitividad + + + + PIFULPGC-2019 + Universidad de Las Palmas de Gran Canaria + + + + + Journal Article + + + 2023 + 02 + 21 + +
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Molecules 24:3799. https://doi.org/10.3390/molecules24203799 + + 10.3390/molecules24203799 + + + + Zhang J-S, Wang Y-Q, Song J-N, Xu J-P, Yang H-B (2020a) Effect of aspartic acid on physiological characteristics and gene expression of salt exclusion in Tartary buckwheat under salt stress. J Plant Biochem Biotechnol 29:94–101. https://doi.org/10.1007/s13562-019-00518-y + + 10.1007/s13562-019-00518-y + + + + Zhang Y, Zuo J, Salimova A, Li A, Li L, Li D (2020b) Phytoplankton distribution characteristics and its relationship with bacterioplankton in Dianchi Lake. Environ Sci Pollut Res 27:40592–40603. https://doi.org/10.1007/s11356-020-10033-6 + + 10.1007/s11356-020-10033-6 + + + + +
+ + + 36809608 + + 2023 + 02 + 22 + +
+ + 1534-4681 + + + 2023 + Feb + 21 + + + Annals of surgical oncology + Ann Surg Oncol + + Nonsentinel Axillary Lymph Node Status in Clinically Node-Negative Early Breast Cancer After Primary Systemic Therapy and Positive Sentinel Lymph Node: A Predictive Model Proposal. + 10.1245/s10434-023-13231-x + + In clinically node-negative (cN0) early stage breast cancer (EBC) undergoing primary systemic treatment (PST), post-treatment positive sentinel lymph node (SLN+) directs axillary lymph node dissection (ALND), with uncertain impacts on outcomes and increased morbidities. + We conducted an observational study on imaging-confirmed cN0 EBC, who underwent PST and breast surgery that resulted in SLN+ and underwent ALND. The association among baseline/postsurgical clinic-pathological factors and positive nonsentinel additional axillary lymph nodes (non-SLN+) was analyzed with logistic regression. LASSO regression (LR) identified variables to include in a predictive score of non-SLN+ (ALND-predict). The accuracy and calibration were assessed, an optimal cut-point was then identified, and in silico validation with bootstrap was undertaken. + Non-SLN+ were detected in 22.2% cases after ALND. Only progesterone receptor (PR) levels and macrometastatic SLN+ were independently associated to non-SLN+. LR identified PR, Ki67, and type and number of SLN+ as the most efficient covariates. The ALND-predict score was built based on their LR coefficients, showing an area under the curve (AUC) of 0.83 and an optimal cut-off of 63, with a negative predictive value (NPV) of 0.925. Continuous and dichotomic scores had a good fit (p = 0.876 and p = 1.00, respectively) and were independently associated to non-SLN+ [adjusted odds ratio (aOR): 1.06, p = 0.002 and aOR: 23.77, p < 0.001, respectively]. After 5000 bootstrap-adjusted retesting, the estimated bias-corrected and accelerated 95%CI included the aOR. + In cN0 EBC with post-PST SLN+, non-SLN+ at ALND are infrequent (~22%) and independently associated to PR levels and macrometastatic SLN. ALND-predict multiparametric score accurately predicted absence of non-SLN involvement, identifying most patients who could be safely spared unnecessary ALND. Prospective validation is required. + © 2023. The Author(s). + + + + Cebrecos + Isaac + I + + Clinic Institute of Gynecology, Obstetrics and Neonatology, Hospital Clinic of Barcelona, Barcelona, Spain. + + + Faculty of Medicine, University of Barcelona, Barcelona, Spain. + + + + Mension + Eduard + E + + Clinic Institute of Gynecology, Obstetrics and Neonatology, Hospital Clinic of Barcelona, Barcelona, Spain. + + + + Alonso + Inmaculada + I + + Clinic Institute of Gynecology, Obstetrics and Neonatology, Hospital Clinic of Barcelona, Barcelona, Spain. + + + Faculty of Medicine, University of Barcelona, Barcelona, Spain. + + + Translational Genomics and Targeted Therapies in Solid Tumors Group, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain. + + + + Castillo + Helena + H + + Clinic Institute of Gynecology, Obstetrics and Neonatology, Hospital Clinic of Barcelona, Barcelona, Spain. + + + + Sanfeliu + Esther + E + + Faculty of Medicine, University of Barcelona, Barcelona, Spain. + + + Translational Genomics and Targeted Therapies in Solid Tumors Group, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain. + + + Department of Pathology, Biomedical Diagnostic Center, Hospital Clinic of Barcelona, Barcelona, Spain. + + + + Vidal-Sicart + Sergi + S + + Department of Nuclear Medicine, Diagnosis Imaging Center, Hospital Clinic of Barcelona, Barcelona, Spain. + + + + Ganau + Sergi + S + + Department of Radiology, Diagnosis Imaging Center, Hospital Clinic of Barcelona, Barcelona, Spain. + + + + Vidal + Maria + M + + Faculty of Medicine, University of Barcelona, Barcelona, Spain. + + + Medical Oncology Department, Hospital Clinic of Barcelona, Barcelona, Spain. + + + Translational Genomics and Targeted Therapies in Solid Tumors Group, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain. + + + + Schettini + Francesco + F + http://orcid.org/0000-0001-6561-1919 + + Faculty of Medicine, University of Barcelona, Barcelona, Spain. schettini@clinic.cat. + + + Medical Oncology Department, Hospital Clinic of Barcelona, Barcelona, Spain. schettini@clinic.cat. + + + Translational Genomics and Targeted Therapies in Solid Tumors Group, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain. schettini@clinic.cat. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Ann Surg Oncol + 9420840 + 1068-9265 + + IM +
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+ + + 36809622 + + 2023 + 02 + 22 + +
+ + 1614-7499 + + + 2023 + Feb + 21 + + + Environmental science and pollution research international + Environ Sci Pollut Res Int + + An atmospheric microwave plasma-based distributed system for medical waste treatment. + 10.1007/s11356-023-25793-0 + + Inadequate handling of infectious medical waste may promote the spread of the virus through secondary transmission during the transfer process. Microwave plasma, an ease-of-use, device-compact, and pollution-free technology, enables the on-site disposal of medical waste, thereby preventing secondary transmission. We developed atmospheric-pressure air-based microwave plasma torches with lengths exceeding 30 cm to rapidly treat various medical wastes in situ with nonhazardous exhaust gas. The gas compositions and temperatures throughout the medical waste treatment process were monitored by gas analyzers and thermocouples in real time. The main organic elements in medical waste and their residues were analyzed by an organic elemental analyzer. The results showed that (i) the weight reduction ratio of medical waste achieved a maximum value of 94%; (ii) a water-waste ratio of 30% was beneficial for enhancing the microwave plasma treatment effect for medical wastes; and (iii) substantial treatment effectiveness was achievable under a high feeding temperature (≥ 600 °C) and a high gas flow rate (≥ 40 L/min). Based on these results, we built a miniaturized and distributed pilot prototype for microwave plasma torch-based on-site medical waste treatment. This innovation could fill the gap in the field of small-scale medical waste treatment facilities and alleviate the existing issue of handling medical waste on-site. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Jie + Ziyao + Z + + Department of Electrical Engineering, Tsinghua University, Beijing, 100084, China. + + + + Liu + Cheng + C + + Research Institute for Environmental Innovation (Suzhou) Tsinghua, Suzhou, 215163, China. + + + + Xia + Daolu + D + + Department of Electrical Engineering, Tsinghua University, Beijing, 100084, China. + + + Suqian Development and Reform Commission, Suqian, 223800, China. + + + + Zhang + Guixin + G + + Department of Electrical Engineering, Tsinghua University, Beijing, 100084, China. guixin@mail.tsinghua.edu.cn. + + + + eng + + + 51176098 + Natural Science Foundation of China + + + + Z191100002019014 + Beijing Science and Technology Planning Project + + + + 2019M660639 + Postdoctoral Research Foundation of China + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Environ Sci Pollut Res Int + 9441769 + 0944-1344 + + IM + + Medical waste + Microwave plasma torch + Thermolysis + Treatment time + Weight reduction rate + +
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+ + + 36809611 + + 2023 + 02 + 22 + +
+ + 1614-7499 + + + 2023 + Feb + 21 + + + Environmental science and pollution research international + Environ Sci Pollut Res Int + + Groundwater quality, heavy metal pollution, and health risk assessment using geospatial techniques and index methods in Eber wetland and surroundings (Afyonkarahisar/Turkey). + 10.1007/s11356-023-25857-1 + + The continuous increase in the demand for water and the scarcity of water to be used as drinking water have made groundwater even more important. The study area, Eber wetland, is located in the Akarçay river basin, which is one of the most important river basins in Turkey. The groundwater quality and heavy metal pollution were investigated in the study using index methods. In addition, health risk assessments were performed. Ion enrichment was determined at locations E10, E11, and E21 related to water-rock interaction. In addition, nitrate pollution was observed in many samples due to agricultural activities and also fertilizer application in the areas. The water quality index (WOI) values of the groundwaters vary between 85.91 and 201.77. In general, groundwater samples located around the wetland were in the "poor water" class. According to the values for the heavy metal pollution index (HPI), all the groundwater samples are suitable for use as drinking water. They are also classified as "low pollution" according to the heavy metal evaluation index (HEI) and the value/degree of contamination (Cd). In addition, since the water is been used for drinking by the people in the area, a health risk assessment was performed to ascertain As and NO3. It was determined that the Rcancer values calculated for As were considerably higher than the tolerable/acceptable values for both adults and children. The results obtained clearly show that the groundwater should not be used as drinking water. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Şener + Şehnaz + Ş + http://orcid.org/0000-0003-3191-2291 + + Department of Geological Engineering, Suleyman Demirel University, Isparta, Turkey. sehnazsener@sdu.edu.tr. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Environ Sci Pollut Res Int + 9441769 + 0944-1344 + + IM + + Drinking water + Eber wetland + Groundwater + Heavy metal pollution index + Human health risk + WQI + +
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+ + 1614-7499 + + + 2023 + Feb + 21 + + + Environmental science and pollution research international + Environ Sci Pollut Res Int + + Optimization of composting methods for efficient use of cassava waste, using microbial degradation. + 10.1007/s11356-023-25818-8 + + With the recent revolution in the green economy, agricultural solid waste resource utilization has become an important project. A small-scale laboratory orthogonal experiment was set up to investigate the effects of C/N ratio, initial moisture content and fill ratio (vcassava residue: vgravel) on the maturity of cassava residue compost by adding Bacillus subtilis and Azotobacter chroococcum. The highest temperature in the thermophilic phase of the low C/N ratio treatment is significantly lower than the medium and high C/N ratios. The C/N ratio and moisture content have a significant impact on the results of cassava residue composting, while the filling ratio only has a significant impact on the pH value and phosphorus content. Based on comprehensive analysis, the recommended process parameters for pure cassava residue composting are a C/N ratio of 25, an initial moisture content of 60%, and a filling ratio of 5. Under these conditions, the high-temperature conditions can be reached and maintained quickly, the organic matter has been degraded by 36.1%, the pH value has dropped to 7.36, the E4/E6 ratio is 1.61, the conductivity value has dropped to 2.52 mS/cm, and the final germination index increased to 88%. The thermogravimetry, scanning electron microscope, and energy spectrum analysis also showed that the cassava residue was effectively biodegraded. Cassava residue composting with this process parameter has great reference significance for the actual production and application of agriculture. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + He + Xiangning + X + + School of Resources, Environment and Materials, Guangxi University, Nanning, 530004, China. + + + + Cong + Riyao + R + + School of Resources, Environment and Materials, Guangxi University, Nanning, 530004, China. + + + + Gao + Wei + W + http://orcid.org/0000-0002-4353-6599 + + School of Resources, Environment and Materials, Guangxi University, Nanning, 530004, China. galaxy@gxu.edu.cn. + + + Guangxi Engineering and Technology Research Center for High Quality Structural Panels From Biomass Wastes, Nanning, 530004, China. galaxy@gxu.edu.cn. + + + + Duan + Xueying + X + + School of Resources, Environment and Materials, Guangxi University, Nanning, 530004, China. + + + + Gao + Yi + Y + + School of Resources, Environment and Materials, Guangxi University, Nanning, 530004, China. + + + + Li + Hong + H + + School of Resources, Environment and Materials, Guangxi University, Nanning, 530004, China. + + + + Li + Zepu + Z + + Agriculture College, Guangxi University, Nanning, 530004, Guangxi, China. + + + Northwest A&F Univ, Coll Forestry, Yangling, 712100, Shaanxi, China. + + + + Diao + Hailin + H + + Forestry College, Guangxi University, Nanning, 530004, Guangxi, China. + + + + Luo + Jianju + J + + School of Resources, Environment and Materials, Guangxi University, Nanning, 530004, China. + + + + eng + + + AA17204067 + Guangxi Innovation-Driven Development Project + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Environ Sci Pollut Res Int + 9441769 + 0944-1344 + + IM + + Cassava residue + Compost + Environment + Maturity + Microorganism + Organic matter + +
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+ + + 36809621 + + 2023 + 02 + 22 + +
+ + 1614-7499 + + + 2023 + Feb + 21 + + + Environmental science and pollution research international + Environ Sci Pollut Res Int + + Nano Pt/TiO2 photocatalyst for ultrafast production of sulfamic acid derivatives using 4-nitroacetanilides as nitrogen precursor in continuous flow reactors. + 10.1007/s11356-023-25968-9 + + The design of reactors based on high performance photocatalysts is an important research in catalytic hydrogenation. In this work, modification of titanium dioxide nanoparticles (TiO2 NPs) was achieved by preparation of Pt/TiO2 nanocomposites (NCs) through photo-deposition method. Both nanocatalysts were used for the photocatalytic removal of SOx from the flue gas at room temperature in the presence of hydrogen peroxide, water, and nitroacetanilide derivatives under visible light irradiation. In this approach, chemical deSOx was achieved along with protection of the nanocatalyst from sulfur poising through the interaction of the released SOx from SOx-Pt/TiO2 surface with p-nitroacetanilide derivatives to produce simultaneous aromatic sulfonic acids. Pt/TiO2 NCs have a bandgap of 2.64 eV in visible light range, which is lower than the bandgap of TiO2 NPs, whereas TiO2 NPs have a mean size of 4 nm and a high specific surface area of 226 m2/g. Pt/TiO2 NCs showed high photocatalytic sulfonation of some phenolic compounds using SO2 as a sulfonating agent along with the existence of p-nitroactanilide derivatives. The conversion of p-nitroacetanilide followed the combination processes of adsorption and catalytic oxidation-reduction reactions. Construction of an online continuous flow reactor-high-resolution time-of-flight mass spectrometry system had been investigated, realizing real-time and automatic monitoring of completion the reaction. 4-nitroacetanilide derivatives (1a-1e) was converted to its corresponding sulfamic acid derivatives (2a-2e) in 93-99% isolated yields of within 60 s. It is expected to offer a great opportunity for ultrafast detection of pharmacophores. + © 2023. The Author(s). + + + + Mohamed + Yasser M A + YMA + + Photochemistry Department, National Research Center, Dokki, Giza, 12622, Egypt. + + + + Attia + Yasser A + YA + http://orcid.org/0000-0002-5830-2250 + + National Institute of Laser Enhanced Sciences, Cairo University, Giza, 12613, Egypt. yasserniles@niles.cu.edu.eg. + + + + eng + + + 43669 + Science and Technology Development Fund + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Environ Sci Pollut Res Int + 9441769 + 0944-1344 + + IM + + Nanoparticles + Organo-sulfonic acid derivatives + Photocatalytic conversion + Pt/TiO2 + Sulfur oxides + +
+ + + + 2022 + 09 + 12 + + + 2023 + 02 + 11 + + + 2023 + 2 + 22 + 13 + 57 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809621 + 10.1007/s11356-023-25968-9 + 10.1007/s11356-023-25968-9 + + + References + + Abdelhamid M, Attia YA, Abdel Harith M (2020) Significance of the nano-shapes in nanoparticle-enhanced laser-induced breakdown spectroscopy. J Anal at Spectrom 35(12):2982–2989 + + 10.1039/D0JA00329H + + + + Abdelsalam EM, Mohamed YMA, Abdelkhalik S, El Nazer H, Attia YA (2020) Photocatalytic oxidation of nitrogen oxides (NOx) using Ag- and Pt-doped TiO2 nanoparticles under visible light irradiation. Environ Sci Pollut Res 27:35828–35836 + + 10.1007/s11356-020-09649-5 + + + + Abdulrasheed AA, Jalil AA, Triwahyono S, Zaini MAA, Gambo Y, Ibrahim M (2018) Surface modification of activated carbon for adsorption of SO2 and NOX: a review of existing and emerging technologies. 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+ + + 36809617 + + 2023 + 02 + 22 + +
+ + 1614-7499 + + + 2023 + Feb + 21 + + + Environmental science and pollution research international + Environ Sci Pollut Res Int + + Ambient nitrogen dioxide and cardiovascular diseases in rural regions: a time-series analyses using data from the new rural cooperative medical scheme in Fuyang, East China. + 10.1007/s11356-023-25922-9 + + Most of studies relating ambient nitrogen dioxide (NO2) exposure to hospital admissions for cardiovascular diseases (CVDs) were conducted among urban population. Whether and to what extent these results could be generalizable to rural population remains unknown. We addressed this question using data from the New Rural Cooperative Medical Scheme (NRCMS) in Fuyang, Anhui, China. Daily hospital admissions for total CVDs, ischaemic heart disease, heart failure, heart rhythm disturbances, ischaemic stroke, and haemorrhagic stroke in rural regions of Fuyang, China, were extracted from NRCMS between January 2015 and June 2017. A two-stage time-series analysis method was used to assess the associations between NO2 and CVD hospital admissions and the disease burden fractions attributable to NO2. In our study period, the average number (standard deviation) of hospital admissions per day were 488.2 (117.1) for total CVDs, 179.8 (45.6) for ischaemic heart disease, 7.0 (3.3) for heart rhythm disturbances, 13.2 (7.2) for heart failure, 267.9 (67.7) for ischaemic stroke, and 20.2 (6.4) for haemorrhagic stroke. The 10-μg/m3 increase of NO2 was related to an elevated risk of 1.9% (RR: 1.019, 95% CI: 1.005 to 1.032) for hospital admissions of total CVDs at lag0-2 days, 2.1% (1.021, 1.006 to 1.036) for ischaemic heart disease, and 2.1% (1.021, 1.006 to 1.035) for ischaemic stroke, respectively, while no significant association was observed between NO2 and hospital admissions for heart rhythm disturbances, heart failure, and haemorrhagic stroke. The attributable fractions of total CVDs, ischaemic heart disease, and ischaemic stroke to NO2 were 6.52% (1.87 to 10.94%), 7.31% (2.19 to 12.17%), and 7.12% (2.14 to 11.85%), respectively. Our findings suggest that CVD burdens in rural population are also partly attributed to short-term exposure to NO2. More studies across rural regions are required to replicate our findings. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Dong + Teng-Fei + TF + + School of Public Health, Department of Epidemiology and Health Statistics, Anhui Medical University, Meishan Road 81, Hefei, 230032, Anhui, China. + + + + Zha + Zhen-Qiu + ZQ + + School of Public Health, Department of Epidemiology and Health Statistics, Anhui Medical University, Meishan Road 81, Hefei, 230032, Anhui, China. + + + Anhui Provincial Center for Disease Control and Prevention, Hefei, 230601, Anhui, China. + + + + Sun + Liang + L + + Fuyang Center for Disease Control and Prevention, Fuyang, 236069, Anhui, China. + + + + Liu + Ling-Li + LL + + School of Public Health, Department of Epidemiology and Health Statistics, Anhui Medical University, Meishan Road 81, Hefei, 230032, Anhui, China. + + + + Li + Xing-Yang + XY + + School of Public Health, Department of Epidemiology and Health Statistics, Anhui Medical University, Meishan Road 81, Hefei, 230032, Anhui, China. + + + + Wang + Yuan + Y + + School of Public Health, Department of Epidemiology and Health Statistics, Anhui Medical University, Meishan Road 81, Hefei, 230032, Anhui, China. + + + + Meng + Xiang-Long + XL + + School of Public Health, Department of Epidemiology and Health Statistics, Anhui Medical University, Meishan Road 81, Hefei, 230032, Anhui, China. + + + + Li + Huai-Biao + HB + + Fuyang Center for Disease Control and Prevention, Fuyang, 236069, Anhui, China. + + + + Wang + Hong-Li + HL + + School of Public Health, Department of Epidemiology and Health Statistics, Anhui Medical University, Meishan Road 81, Hefei, 230032, Anhui, China. + + + + Nie + Huan-Huan + HH + + School of Public Health, Department of Epidemiology and Health Statistics, Anhui Medical University, Meishan Road 81, Hefei, 230032, Anhui, China. + + + + Yang + Lin-Sheng + LS + http://orcid.org/0000-0002-8025-8022 + + School of Public Health, Department of Epidemiology and Health Statistics, Anhui Medical University, Meishan Road 81, Hefei, 230032, Anhui, China. yanglinsheng@ahmu.edu.cn. + + + + eng + + + KJ2017A189 + Key Scientific Research Fund of Anhui Provincial Education Department + + + + Xj201525 + Grants for Scientific Research of BSKY from Anhui Medical University + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Environ Sci Pollut Res Int + 9441769 + 0944-1344 + + IM + + Cardiovascular diseases + Hospital admissions + Nitrogen dioxide + Rural regions + +
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+ + + 36809618 + + 2023 + 02 + 22 + +
+ + 1614-7499 + + + 2023 + Feb + 21 + + + Environmental science and pollution research international + Environ Sci Pollut Res Int + + A regional appraisal of electricity accessibility determinants: the relevance of international remittances, clean energy, income inequality, and institutional quality. + 10.1007/s11356-023-25889-7 + + The majority of developing nations worldwide face severe challenges in ensuring universal electricity access for their respective populations. Hence, this study focuses on assessing the factors stimulating and inhibiting national electricity access rates in 61 developing nations from six global regions during the 2000-2020 period. For analytical purposes, both parametric and non-parametric estimation techniques that are efficient in handling major panel data-related problems are used. Overall, the results reveal that a higher influx of remittances sent by the expatriates does not directly influence electricity accessibility. However, adoption of clean energy and improvement in institutional quality promote electricity accessibility while higher income inequality undermines it. More importantly, good institutional quality mediates between international remittance receipts and electricity accessibility as results endorse that international remittance receipts and institutional quality improvement jointly exert electricity accessibility-promoting impacts. Moreover, these findings depict regional heterogeneity while the quantile-based analysis highlights contrasting impacts of international remittance receipts, clean energy use, and institutional quality across different quantiles of electricity accessibility. Contrarily, worsening incidences of income inequality are evidenced to undermine electricity accessibility across all quantiles. Therefore, considering these key findings, several electricity accessibility-boosting policies are suggested. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Murshed + Muntasir + M + + Department of Economics, School of Business and Economics, North South University, Dhaka-1229, Bangladesh. muntasir.murshed@northsouth.edu. + + + Department of Journalism, Media and Communications, Daffodil International University, Dhaka, Bangladesh. muntasir.murshed@northsouth.edu. + + + Bangladesh Institute of Development Studies, E-17 Agargaon, Sher-e-Bangla Nagar, Dhaka-1207, Bangladesh. muntasir.murshed@northsouth.edu. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Environ Sci Pollut Res Int + 9441769 + 0944-1344 + + IM + + Clean energy + Developing countries + Electricity accessibility + Institutional quality + Remittances + +
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+ + 1614-7499 + + + 2023 + Feb + 21 + + + Environmental science and pollution research international + Environ Sci Pollut Res Int + + Cyclic volatile methyl siloxanes (D4, D5, and D6) as the emerging pollutants in environment: environmental distribution, fate, and toxicological assessments. + 10.1007/s11356-023-25568-7 + + Cyclic volatile methyl siloxanes (cVMS) have now become a subject of environmental contamination and risk assessment due to their widespread use and occurrence in different environmental matrices. Due to their exceptional physio-chemical properties, these compounds are diversely used for formulations of consumer products and others implying their continuous and significant release to environmental compartments. This has captured the major attention of the concerned communities on the grounds of potential health hazards to human and biota. The present study aims at comprehensively reviewing its occurrence in air, water, soil, sediments, sludge, dusts, biogas, biosolids, and biota and their environmental behavior as well. Concentrations of cVMS in indoor air and biosolids were higher; however, no significant concentrations were observed in water, soil, and sediments except for wastewaters. No threat to the aquatic organisms has been identified as their concentrations do not exceed the NOEC (maximum no observed effect concentration) thresholds. Mammalian (rodents) toxicity hazards were not very evident except for the occurrence of uterine tumors in very rare cases under long-term chronic and repeated dose exposures in laboratory conditions. Human relevancy to rodents were also not strongly enough established. Therefore, more careful examinations are required to develop stringent weight of evidences in scientific domain and ease the policy making with respect to their production and use so as to combat any environmental consequences. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Kumari + Kanchan + K + + CSIR-National Environmental Engineering Research Institute (NEERI), Kolkata Zonal Centre, 700 107, Kolkata, West Bengal, India. onlinekanchan1@gmail.com. + + + Academy of Scientific and Innovative Research (AcSIR), Uttar Pradesh, Ghaziabad, 201 002, India. onlinekanchan1@gmail.com. + + + + Singh + Anshika + A + + Academy of Scientific and Innovative Research (AcSIR), Uttar Pradesh, Ghaziabad, 201 002, India. + + + CSIR-National Environmental Engineering Research Institute (NEERI), Nagpur, 440020, Maharashtra, India. + + + + Marathe + Deepak + D + + Academy of Scientific and Innovative Research (AcSIR), Uttar Pradesh, Ghaziabad, 201 002, India. + + + CSIR-National Environmental Engineering Research Institute (NEERI), Nagpur, 440020, Maharashtra, India. + + + + eng + + Journal Article + Review + + + 2023 + 02 + 21 + +
+ + Germany + Environ Sci Pollut Res Int + 9441769 + 0944-1344 + + IM + + Bioaccumulation + Biomagnification + Cyclic volatile methyl siloxanes + Environmental behavior + Partitioning coefficient + Toxicity + +
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+ + + 36809620 + + 2023 + 02 + 22 + +
+ + 1614-7499 + + + 2023 + Feb + 21 + + + Environmental science and pollution research international + Environ Sci Pollut Res Int + + Defining the roles of socio-economic factors and bureaucratic quality to minimize the impacts of fossil fuels consumption on CO2 emissions in G-20 countries. + 10.1007/s11356-023-25964-z + + G-20 nations are committed to reducing CO2 emissions considering their commitments to the United Nations. Therefore, this work investigates the associations between bureaucratic quality, socio-economic factors, fossil fuel consumption, and CO2 emissions from 1990 to 2020. To counter the problem of cross-sectional dependence, this work applies to cross-sectional autoregressive distributed lag (CS-ARDL). The valid second-generation methodologies are applied, and the results cannot be found in the environmental Kuznets curve (EKC). Fossil fuels (coal, gas, oil) exert a negative impact on environmental quality. The direct impact of bureaucratic quality and socio-economic factors are suitable to lower CO2 emissions. A 1% increase in bureaucratic quality and socio-economic factors will lower CO2 emissions by 0.174% and 0.078% respectively in the long run. The indirect effect of bureaucratic quality and socio-economic factors is significant in reducing the CO2 emissions created by fossil fuels. The wavelet plots also validate these findings that bureaucratic quality is important to lower environmental pollution in 18 G-20 member countries. Considering the findings, this research presents important policy instruments that there is a need to bring clean energy sources into the total energy mix. For this purpose, it is important to improve bureaucratic quality to speed up the decision-making process for clean energy infrastructural development. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Abou Houran + Mohamad + M + + School of Electrical Engineering, Xi'an Jiaotong University, Shaanxi, Xi'an, China. + + + + Mehmood + Usman + U + http://orcid.org/0000-0001-9034-5878 + + University of Management and Technology, Lahore, Pakistan. usmanmehmood.umt@gmail.com. + + + Remote Sensing, GIS and Climatic Research Lab (RSGCRL), National Center of GIS and Space Applications, Centre for Remote Sensing, University of the Punjab, Lahore, Pakistan. usmanmehmood.umt@gmail.com. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Environ Sci Pollut Res Int + 9441769 + 0944-1344 + + IM + + Bureaucratic quality + CO2 emissions + Fossil fuel use + G-20 countries + Socio-economic factors + +
+ + + + 2022 + 10 + 31 + + + 2023 + 02 + 11 + + + 2023 + 2 + 22 + 13 + 57 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809620 + 10.1007/s11356-023-25964-z + 10.1007/s11356-023-25964-z + + + References + + (2020) OECD tourism trends and policies 2020. https://doi.org/10.1787/6b47b985-en + + + Abid M (2017) Does economic, financial and institutional developments matter for environmental quality? A comparative analysis of EU and MEA countries. J Environ Manag 188:183–194. https://doi.org/10.1016/j.jenvman.2016.12.007 + + 10.1016/j.jenvman.2016.12.007 + + + + Adedoyin FF, Bekun FV, Alola AA (2020) Growth impact of transition from non-renewable to renewable energy in the EU: the role of research and development expenditure. 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+ + + 36809616 + + 2023 + 02 + 22 + +
+ + 1614-7499 + + + 2023 + Feb + 21 + + + Environmental science and pollution research international + Environ Sci Pollut Res Int + + Degradation of atrazine in river sediment by dielectric barrier discharge plasma (DBDP) combined with a persulfate (PS) oxidation system: response surface methodology, degradation mechanisms, and pathways. + 10.1007/s11356-022-24927-0 + + Single degradation systems based on dielectric barrier discharge plasma (DBDP) or persulfate (PS) oxidation cannot achieve the desired goals (high degradation efficiency, high mineralization rate, and low product toxicity) of degrading atrazine (ATZ) in river sediment. In this study, DBDP was combined with a PS oxidation system (DBDP/PS synergistic system) to degrade ATZ in river sediment. A Box-Behnken design (BBD) including five factors (discharge voltage, air flow, initial concentration, oxidizer dose, and activator dose) and three levels (- 1, 0, and 1) was established to test a mathematical model by response surface methodology (RSM). The results confirmed that the degradation efficiency of ATZ in river sediment was 96.5% in the DBDP/PS synergistic system after 10 min of degradation. The experimental total organic carbon (TOC) removal efficiency results indicated that 85.3% of ATZ is mineralized into CO2, H2O, and NH4+, which effectively reduces the possible biological toxicity of the intermediate products. Active species (sulfate (SO4-), hydroxy (•OH), and superoxide (•O2-) radicals) were found to exert positive effects in the DBDP/PS synergistic system and illustrated the degradation mechanism of ATZ. The ATZ degradation pathway, composed of 7 main intermediates, was clarified by Fourier transform infrared spectroscopy (FTIR) and gas chromatography-mass spectrometry (GC-MS). This study indicates that the DBDP/PS synergistic system is a highly efficient, environmentally friendly, novel method for the remediation of river sediment containing ATZ pollution. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Lu + Hongyu + H + + School of Biology, Food, and Environment, Hefei University, No. 99 Jinxiu Road, Hefei, 230601, China. + + + Heifei Engineering Research Center for Soil and Groundwater Remediation, Hefei, 230088, China. + + + + Gao + Wei + W + + School of Biology, Food, and Environment, Hefei University, No. 99 Jinxiu Road, Hefei, 230601, China. + + + + Deng + Chengxun + C + + School of Biology, Food, and Environment, Hefei University, No. 99 Jinxiu Road, Hefei, 230601, China. dcx@hfuu.edu.cn. + + + Heifei Engineering Research Center for Soil and Groundwater Remediation, Hefei, 230088, China. dcx@hfuu.edu.cn. + + + + Liu + Xiaowei + X + + School of Biology, Food, and Environment, Hefei University, No. 99 Jinxiu Road, Hefei, 230601, China. + + + Heifei Engineering Research Center for Soil and Groundwater Remediation, Hefei, 230088, China. + + + + Li + Weiping + W + + Heifei Engineering Research Center for Soil and Groundwater Remediation, Hefei, 230088, China. + + + Anhui Guozhen Environmental Remediation Co., Ltd, Hefei, 230088, China. + + + + Yu + Zhimin + Z + + School of Biology, Food, and Environment, Hefei University, No. 99 Jinxiu Road, Hefei, 230601, China. + + + Heifei Engineering Research Center for Soil and Groundwater Remediation, Hefei, 230088, China. + + + + Ding + Haitao + H + + School of Biology, Food, and Environment, Hefei University, No. 99 Jinxiu Road, Hefei, 230601, China. + + + + Zhang + Ling + L + + School of Biology, Food, and Environment, Hefei University, No. 99 Jinxiu Road, Hefei, 230601, China. + + + Heifei Engineering Research Center for Soil and Groundwater Remediation, Hefei, 230088, China. + + + + eng + + + 52070063 + National Natural Science Foundation of China + + + + 202003a06020024 + Major Science and Technology Project of Anhui Province + + + + KJ2021A1011 + Key Projects of Natural Science Research of Anhui Universities + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Environ Sci Pollut Res Int + 9441769 + 0944-1344 + + IM + + Atrazine degradation + Dielectric barrier discharge plasma + Persulfate oxidation system + River sediment remediation + Synergistic treatment + +
+ + + + 2022 + 09 + 24 + + + 2022 + 12 + 19 + + + 2023 + 2 + 22 + 13 + 57 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809616 + 10.1007/s11356-022-24927-0 + 10.1007/s11356-022-24927-0 + + + References + + Bandara TTA, Viera JC, González M (2022) The next generation of fast charging methods for Lithium-ion batteries: the natural current-absorption methods. Renew Sust Energ Rev 162:112338 + + 10.1016/j.rser.2022.112338 + + + + Chao HZ, Sun MM, Wu YL, Xia R, Yuan SJ, Hu F (2022) Quantitative relationship between earthworms’ sensitivity to organic pollutants and the contaminants’ degradation in soil: a meta-analysis. J Hazard Mater 429:128286 + + 10.1016/j.jhazmat.2022.128286 + + + + Chen L, Duan J, Du PH, Sun WL, Lai B, Liu W (2022) Accurate identification of radicals by in-situ electron paramagnetic resonance in ultraviolet-based homogenous advanced oxidation processes. 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+ + + 36809614 + + 2023 + 02 + 22 + +
+ + 1614-7499 + + + 2023 + Feb + 21 + + + Environmental science and pollution research international + Environ Sci Pollut Res Int + + Chitosan-modified magnetic carbon nanomaterials with high efficiency, controlled motility, and reusability-for removal of chromium ions from real wastewater. + 10.1007/s11356-023-25302-3 + + Hexavalent chromium Cr(VI) is one of the most hazardous oxygen-containing anions to human health and the environment. Adsorption is considered to be an effective method for the removal of Cr(VI) from aqueous solutions. Based on an environmental perspective, we used renewable biomass cellulose as carbon source and chitosan as functional material to synthesize chitosan-coated magnetic carbon (MC@CS) material. The synthesized chitosan magnetic carbons were uniform in diameter (~ 20 nm) and contain a large number of abundant hydroxyl and amino functional groups on the surface, meanwhile owning excellent magnetic separation properties. The MC@CS exhibited high adsorption capacity (83.40 mg/g) at pH 3 and excellent cycling regeneration ability when applied to Cr(VI) removal in water, removal rate of Cr(VI) (10 mg/L) was still over 70% after 10 cycles. FT-IR and XPS spectra showed that electrostatic interaction and reduction with Cr(VI) are the main mechanisms of Cr(VI) removal by MC@CS nanomaterial. This work provides an environment-friendly adsorption material that could be reused for the removal of Cr(VI) in multiple cycles. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Li + Zhishuncheng + Z + + Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, 727 Jingmingnan Road, Kunming, 650500, Yunnan, China. + + + National Regional Engineering Research Center-NCW, Kunming, 650500, Yunnan, China. + + + + Yang + Can + C + + Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, 727 Jingmingnan Road, Kunming, 650500, Yunnan, China. + + + National Regional Engineering Research Center-NCW, Kunming, 650500, Yunnan, China. + + + + Qu + Guangfei + G + http://orcid.org/0000-0002-3006-3112 + + Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, 727 Jingmingnan Road, Kunming, 650500, Yunnan, China. 15912501574@163.com. + + + National Regional Engineering Research Center-NCW, Kunming, 650500, Yunnan, China. 15912501574@163.com. + + + + Cui + Qingyuan + Q + + Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, 727 Jingmingnan Road, Kunming, 650500, Yunnan, China. + + + National Regional Engineering Research Center-NCW, Kunming, 650500, Yunnan, China. + + + + Yang + Yixin + Y + + Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, 727 Jingmingnan Road, Kunming, 650500, Yunnan, China. + + + National Regional Engineering Research Center-NCW, Kunming, 650500, Yunnan, China. + + + + Ren + Yuanchuan + Y + + Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, 727 Jingmingnan Road, Kunming, 650500, Yunnan, China. + + + National Regional Engineering Research Center-NCW, Kunming, 650500, Yunnan, China. + + + + Yang + Yuyi + Y + + Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, 727 Jingmingnan Road, Kunming, 650500, Yunnan, China. + + + National Regional Engineering Research Center-NCW, Kunming, 650500, Yunnan, China. + + + + Wang + Fang + F + + Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, 727 Jingmingnan Road, Kunming, 650500, Yunnan, China. + + + National Regional Engineering Research Center-NCW, Kunming, 650500, Yunnan, China. + + + + eng + + + 2018YFC1801702 + Key Technologies Research and Development Program + + + + 2018YFC1900203 + Key Technologies Research and Development Program + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Environ Sci Pollut Res Int + 9441769 + 0944-1344 + + IM + + Adsorption + Chitosan + Chromium + Magnetic carbon + Nanometer material + +
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+ + + 36809619 + + 2023 + 02 + 22 + +
+ + 1614-7499 + + + 2023 + Feb + 21 + + + Environmental science and pollution research international + Environ Sci Pollut Res Int + + A comprehensive study for Al2O3 nanofluid cooling effect on the electrical and thermal properties of polycrystalline solar panels in outdoor conditions. + 10.1007/s11356-023-25928-3 + + Photovoltaic (PV) technology is considered one of the most effective and promising renewable sources of energy. The PV system's efficiency strongly depends on its operating temperature, which acts as a defect to the electrical efficiency by increasing over 25 °C. In this work, a comparison was performed between three traditional polycrystalline solar panels simultaneously at the same time and under the same weather conditions. The electrical and thermal performances of the photovoltaic thermal (PVT) system integrated with a serpentine coil configured sheet with a plate thermal absorber setup are evaluated using water and aluminum oxide nanofluid. For higher mass flow rates and nanoparticle concentrations, an improvement in the PV modules short-circuit current (Isc) and open-circuit voltage (Voc) yield and electrical conversion efficiency is achieved. The enhancement in the PVT electrical conversion efficiency is 15.5%. For 0.05% volume concentration of Al2O3 and flow rate of 0.07 kg/s, an enhancement of 22.83% of the temperature of PVT panels' surface over the reference panel has been obtained. An uncooled PVT system reached a maximum panel temperature of 75.5 °C at noontime and obtained an average electrical efficiency of 12.156%. Water and nanofluid cooling reduce the panel temperature by 10.0 °C and 20.0 °C at noontime, respectively. + © 2023. The Author(s). + + + + Ibrahim + Ali + A + + Physics Department, Faculty of Science, Tanta University, Tanta, 31 527, Egypt. ali.ibrahim1@science.tanta.edu.eg. + + + + Ramadan + Muhammad Raafat + MR + + Physics Department, Faculty of Science, Tanta University, Tanta, 31 527, Egypt. + + + + Khallaf + Abd El-Monem + AE + + Department of Basic Science, Misr Higher Institute for Engineering and Technology, Mansoura, Egypt. + + + + Abdulhamid + Muhammad + M + + Physics Department, Faculty of Science, Tanta University, Tanta, 31 527, Egypt. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Environ Sci Pollut Res Int + 9441769 + 0944-1344 + + IM + + Al2O3 nanoparticles + Nanofluid cooling + PV efficiency enhancement + Photovoltaic panels cooling + +
+ + + + 2022 + 07 + 22 + + + 2023 + 02 + 09 + + + 2023 + 2 + 22 + 13 + 57 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809619 + 10.1007/s11356-023-25928-3 + 10.1007/s11356-023-25928-3 + + + + Abbas N, Awan MB, Amer M, Ammar SM, Sajjad U, Ali HM, Zahra N, Hussain M, Badshah MA (2019) Jafry AT (2019) Applications of nanofluids in photovoltaic thermal systems: a review of recent advances. Physica A 536(15):122513 + + 10.1016/j.physa.2019.122513 + + + + Abbood MH, Shahad H, Kadhum Ali AA (2020) Improving the electrical efficiency of a photovoltaic/thermal panel by using sic/water nanofluid as coolant. IOP Conf Ser Mater Sci Eng 671:012143 (IOP Publishing) + + 10.1088/1757-899X/671/1/012143 + + + + Abdo S, Saidani-Scott H (2021) Effect of using saturated hydrogel beads with alumina water-based nanofluid for cooling solar panels: experimental study with economic analysis. 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+ + + 36809623 + + 2023 + 02 + 22 + +
+ + 1614-7499 + + + 2023 + Feb + 21 + + + Environmental science and pollution research international + Environ Sci Pollut Res Int + + China's energy policy and sustainable energy transition for sustainable development: green investment in renewable technological paradigm. + 10.1007/s11356-023-25734-x + + It is generally accepted that China is a significant cause of global warming and other climate change consequences. This paper applies panel cointegration tests and autoregressive distributed lag (ARDL) techniques to investigate the interactions among energy policy, technological innovation, economic development, trade openness, and sustainable development using panel data from China from 1990 to 2020. Results explain that renewable energy policy and technology innovation are negatively associated with sustainable development. However, research shows that energy use significantly increases both short-term and long-term environmental damage. The findings show that economic growth has a lasting impact on the environment by distorting it. The findings recommend that politicians and government officials hold the key to attaining a green and clean environment by focusing on developing the proper energy policy mix, urban planning, and pollution prevention without compromising economic growth. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Wang + Chenrong + C + + School of Business, Zhengzhou University of Economics and Business, Zhengzhou, 451191, China. 1052080357@qq.com. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
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+ + + 36809624 + + 2023 + 02 + 22 + +
+ + 1614-7499 + + + 2023 + Feb + 21 + + + Environmental science and pollution research international + Environ Sci Pollut Res Int + + Doping rare earth cations with an additional chemical reduction synergistically weakened the photocatalytic performance of ceria. + 10.1007/s11356-023-25981-y + + Chemical reducing or rare earth cations (RE) doping was normally employed to promote the photocatalytic performance of ceria, aimed to evaluate their cooperation influences, ceria was obtained by decomposing homogenously RE (RE = La, Sm, and Y)-doped CeCO3OH in H2. XPS and EPR results evidenced that the excess oxygen vacancies (OVs) were formed in RE-doped CeO2 compared to the un-doped ceria. However, all the RE-doped ceria unexpectedly showed an impeded photocatalytic activity towards to methylene blue (MB) photodegradation. The 5% Sm-doped ceria had the best MB photodegradation ratio of 81.47% after 2-h reaction in all RE-doped samples, which was lower than that of 87.24% for the un-doped ceria. After doping RE cations and chemical reducing, the band gap of ceria were almost narrowed, while the PL spectra and photo-electro characterizations indicated that the separation efficiency of photo-excited e-/h+ (electrons/holes) was reduced. The RE dopants and formed excess OVs including inner and surface OVs was proposed to promote the recombination of e-/h+ which further hindered the generation of active species of ·O2- and ·OH, and finally weakened the photocatalytic activity of ceria. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Zhang + Junshan + J + + Department of Metallurgical Engineering, College of Materials and Metallurgy, Guizhou University, Huaxi, Guiyang, 550025, Guizhou, China. + + + Guizhou Province Key Laboratory of Metallurgical Engineering and Process Energy Saving, Guiyang, 550025, Guizhou, China. + + + + Mao + Xisong + X + + Department of Metallurgical Engineering, College of Materials and Metallurgy, Guizhou University, Huaxi, Guiyang, 550025, Guizhou, China. + + + Guizhou Province Key Laboratory of Metallurgical Engineering and Process Energy Saving, Guiyang, 550025, Guizhou, China. + + + + Lan + Yuanpei + Y + http://orcid.org/0000-0002-3046-5330 + + Department of Metallurgical Engineering, College of Materials and Metallurgy, Guizhou University, Huaxi, Guiyang, 550025, Guizhou, China. yplan@gzu.edu.cn. + + + Guizhou Province Key Laboratory of Metallurgical Engineering and Process Energy Saving, Guiyang, 550025, Guizhou, China. yplan@gzu.edu.cn. + + + + Li + Junqi + J + + Department of Metallurgical Engineering, College of Materials and Metallurgy, Guizhou University, Huaxi, Guiyang, 550025, Guizhou, China. + + + Guizhou Province Key Laboratory of Metallurgical Engineering and Process Energy Saving, Guiyang, 550025, Guizhou, China. + + + + Chen + Chaoyi + C + + Department of Metallurgical Engineering, College of Materials and Metallurgy, Guizhou University, Huaxi, Guiyang, 550025, Guizhou, China. + + + Guizhou Province Key Laboratory of Metallurgical Engineering and Process Energy Saving, Guiyang, 550025, Guizhou, China. + + + + Yang + Jian + J + + College of Materials Science and Engineering, Chongqing University, Shapingba, Chongqing, 400030, China. + + + + Zhang + Wei + W + + Department of Metallurgical Engineering, College of Materials and Metallurgy, Guizhou University, Huaxi, Guiyang, 550025, Guizhou, China. + + + Guizhou Province Key Laboratory of Metallurgical Engineering and Process Energy Saving, Guiyang, 550025, Guizhou, China. + + + + Murali + Arun + A + + Department of Materials Science and Engineering, University of Utah, Salt Lake City, UT, 84112, USA. + + + + Liu + Li + L + + Department of Metallurgical Engineering, College of Materials and Metallurgy, Guizhou University, Huaxi, Guiyang, 550025, Guizhou, China. + + + Guizhou Province Key Laboratory of Metallurgical Engineering and Process Energy Saving, Guiyang, 550025, Guizhou, China. + + + + Wang + Qin + Q + + Department of Metallurgical Engineering, College of Materials and Metallurgy, Guizhou University, Huaxi, Guiyang, 550025, Guizhou, China. + + + Guizhou Province Key Laboratory of Metallurgical Engineering and Process Energy Saving, Guiyang, 550025, Guizhou, China. + + + + eng + + + 52164025 + National Natural Science Foundation of China + + + + + Journal Article + + + 2023 + 02 + 21 + +
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+ + + 36809628 + + 2023 + 02 + 22 + +
+ + 1614-7499 + + + 2023 + Feb + 21 + + + Environmental science and pollution research international + Environ Sci Pollut Res Int + + Performance and mechanism of sacrificed iron anode coupled with constructed wetlands (E-Fe) for simultaneous nitrogen and phosphorus removal. + 10.1007/s11356-023-25860-6 + + Three anodic biofilm electrode coupled CWs (BECWs) with graphite (E-C), aluminum (E-Al), and iron (E-Fe), respectively, and a control system (CK) were constructed to evaluate the removal performance of N and P in the secondary effluent of wastewater treatment plants (WWTPs) under different hydraulic retention time (HRT), electrified time (ET), and current density (CD). Microbial communities, and different P speciation, were analyzed to reveal the potential removal pathways and mechanism of N and P in BECWs. Results showed that the optimal average TN and TP removal rates of CK (34.10% and 55.66%), E-C (66.77% and 71.33%), E-Al (63.46% and 84.93%), and E-Fe (74.93% and 91.22%) were obtained under the optimum conditions (HRT 10 h, ET 4 h, CD 0.13 mA/cm2), which demonstrated that the biofilm electrode could significantly improve N and P removal. Microbial community analysis showed that E-Fe owned the highest abundance of chemotrophic Fe(II) (Dechloromonas) and hydrogen autotrophic denitrifying bacteria (Hydrogenophaga). N was mainly removed by hydrogen and iron autotrophic denitrification in E-Fe. Moreover, the highest TP removal rate of E-Fe was attributed to the iron ion formed on the anode, causing co-precipitation of Fe(II) or Fe(III) with PO43--P. The Fe released from the anode acted as carriers for electron transport and accelerated the efficiency of biological and chemical reactions to enhance the simultaneous removal of N and P. Thus, BECWs provide a new perspective for the treatment of the secondary effluent from WWTPs. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Zhou + Ming + M + + Key Laboratory of Integrated Regulation and Resource Development On Shallow Lakes, Ministry of Education, Hohai University, Nanjing, 210098, China. + + + College of Environment, Hohai University, Nanjing, 210098, China. + + + Henan Yongze Environmental Technology Co., Ltd, Zhengzhou, 451191, China. + + + + Cao + Jiashun + J + + Key Laboratory of Integrated Regulation and Resource Development On Shallow Lakes, Ministry of Education, Hohai University, Nanjing, 210098, China. + + + College of Environment, Hohai University, Nanjing, 210098, China. + + + + Qiu + Yuanyuan + Y + + Henan Yongze Environmental Technology Co., Ltd, Zhengzhou, 451191, China. + + + + Lu + Yanhong + Y + + Henan Yongze Environmental Technology Co., Ltd, Zhengzhou, 451191, China. + + + + Guo + Jinyan + J + + Henan Yongze Environmental Technology Co., Ltd, Zhengzhou, 451191, China. + + + + Li + Chao + C + + Key Laboratory of Integrated Regulation and Resource Development On Shallow Lakes, Ministry of Education, Hohai University, Nanjing, 210098, China. 27394574@qq.com. + + + College of Environment, Hohai University, Nanjing, 210098, China. 27394574@qq.com. + + + + Wang + Yantang + Y + + Henan Yongze Environmental Technology Co., Ltd, Zhengzhou, 451191, China. + + + + Hao + Liangshan + L + + Key Laboratory of Integrated Regulation and Resource Development On Shallow Lakes, Ministry of Education, Hohai University, Nanjing, 210098, China. + + + College of Environment, Hohai University, Nanjing, 210098, China. + + + + Ren + Hongqiang + H + + College of Environment, Nanjing University, Nanjing, 210093, China. + + + + eng + + + No. BE2022861 + the Major science and technology demonstration projects of carbon peak and carbon neutral technology innovation in Jiangsu Province + + + + No.2019KJGG14 + Science and technology project of Henan Province + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Environ Sci Pollut Res Int + 9441769 + 0944-1344 + + IM + + Autotrophic denitrifying + Constructed wetlands + Electrochemical flocculation + N and P removal + Sacrificed anode + +
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+ + + 36809629 + + 2023 + 02 + 22 + +
+ + 1614-7499 + + + 2023 + Feb + 21 + + + Environmental science and pollution research international + Environ Sci Pollut Res Int + + The evolution process of ecological vulnerability and its quantitative analysis of influencing factors: a case study of Longdong area. + 10.1007/s11356-023-25583-8 + + Ecological vulnerability is the main index to evaluate areal environmental stability and monitor the development of ecological environment. Longdong area is a typical Loess Plateau area with complex terrain, serious soil erosion, mineral resource development, and other human activities leading to the ecological vulnerability evolution of the area, but the monitoring of its ecological status and the determination of its factors are still lacking. Based on the ecological characteristics of Longdong area, this study constructed an ecological vulnerability system including natural, social, and economic data and used the fuzzy analytic hierarchy process (FAHP) to study the temporal and spatial evolution of ecological vulnerability from 2006 to 2018. A model for quantitative analysis of the evolution of ecological vulnerability and correlation of influencing factors was ultimately developed. The results showed that (1) from 2006 to 2018, the ecological vulnerability index (EVI) had a minimum value of 0.232 and a maximum value of 0.695. EVI was high in the northeast and southwest of Longdong area and low in the central region. (2) At the same time, the areas of potential vulnerability and mild vulnerability increased, and the areas of slight vulnerability, moderate vulnerability, and severe vulnerability decreased. (3) The correlation coefficient between average annual temperature and EVI exceeded 0.5 in four years, and the correlation coefficient between population density and per capita arable land area and EVI exceeded 0.5 in two years showed significant correlation. The results reflect the spatial pattern and influencing factors of ecological vulnerability in typical arid areas of northern China. Additionally, it served as a resource for researching the interrelationships of the variables affecting ecological vulnerability. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Ma + Lixia + L + + School of Environmental and Chemical Engineering, Xi'an Polytechnic University, Xi'an, 710048, China. + + + + Kang + Hou + H + + School of Environmental and Chemical Engineering, Xi'an Polytechnic University, Xi'an, 710048, China. houkang0311@stu.xjtu.edu.cn. + + + + He + Dan + D + + School of Environmental and Chemical Engineering, Xi'an Polytechnic University, Xi'an, 710048, China. + + + + Liu + Jiawei + J + + School of Environmental and Chemical Engineering, Xi'an Polytechnic University, Xi'an, 710048, China. + + + + Tang + Haojie + H + + School of Environmental and Chemical Engineering, Xi'an Polytechnic University, Xi'an, 710048, China. + + + + Wu + Siqi + S + + School of Environmental and Chemical Engineering, Xi'an Polytechnic University, Xi'an, 710048, China. + + + + Li + Xuxiang + X + + School of Human Settlements and Civil Engineering, Xi'an Jiao Tong University, Xi'an, 710049, China. + + + + eng + + + 2022JQ-282 + Key Science and Technology Program of Shaanxi Province + + + + 42007415 + National Natural Science Foundation of China + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Environ Sci Pollut Res Int + 9441769 + 0944-1344 + + IM + + Ecological vulnerability + Evolution process + Influencing factors + Longdong area + Relevance analysis + +
+ + + + 2022 + 09 + 12 + + + 2023 + 01 + 23 + + + 2023 + 2 + 22 + 13 + 57 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809629 + 10.1007/s11356-023-25583-8 + 10.1007/s11356-023-25583-8 + + + + Ayhan MB (2013) A fuzzy AHP approach for supplier selection problem: a case study in a gear motor company. International Journal of Managing Value and Supply Chains 4(3):11–23 + + 10.5121/ijmvsc.2013.4302 + + + + Bennett NJ et al (2016) Communities and change in the anthropocene: understanding social-ecological vulnerability and planning adaptations to multiple interacting exposures. Reg Environ Change 16(4):907–926 + + 10.1007/s10113-015-0839-5 + + + + Cao S, Chen L, Liu Z (2007) Disharmony between society and environmental carrying capacity: a historical review, with an emphasis on China. 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+ + + 36809635 + + 2023 + 02 + 22 + +
+ + 2212-5469 + + + 2023 + Feb + 21 + + + Tissue engineering and regenerative medicine + Tissue Eng Regen Med + + Pathological Characteristics of Monosodium Iodoacetate-Induced Osteoarthritis in Rats. + 10.1007/s13770-023-00520-5 + + This study aimed to identify pain-related behavior and pathological characteristics of the knee joint in rats with monosodium iodoacetate (MIA)-induced osteoarthritis (OA). + Knee joint inflammation was induced by intra-articular injection of MIA (4 mg/50 µL, n = 14) in 6-week-old male rats. Knee joint diameter, weight-bearing percentage on the hind limb during walking, the knee bending score, and paw withdrawal to mechanical stimuli were measured to evaluate edema and pain-related behavior for 28 d after MIA injection. Histological changes in the knee joints were evaluated using safranin O fast green staining on days 1, 3, 5, 7, 14, and 28 after OA induction (n = 3, respectively). Changes in bone structure and bone mineral density (BMD) were examined 14 and 28 d after OA (n = 3, respectively) using micro-computed tomography (CT). + The knee joint diameter and knee bending scores of the ipsilateral joint significantly increased 1 d after MIA injection, and the increased knee joint diameter and knee bending score persisted for 28 d. Weight-bearing during walking and paw withdrawal threshold (PWT) decreased from 1 and 5 d, respectively, and were maintained up to 28 d after MIA. Cartilage destruction started on day 1, and Mankin scores for bone destruction significantly increased for 14 d, as shown by micro-CT imaging. + The present study demonstrated that histopathological structural changes in the knee joint due to inflammation started soon after MIA injection, which induced OA pain from inflammation-related acute pain to spontaneous and evoked associated chronic pain. + © 2023. Korean Tissue Engineering and Regenerative Medicine Society. + + + + Kwon + Minji + M + + Rehabilitation Science Program, Department of Health Science, Graduate School, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea. + + + Transdisciplinary Major in Learning Health Systems, Department of Healthcare Sciences, Graduate School, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea. + + + + Nam + Dongyeon + D + + Rehabilitation Science Program, Department of Health Science, Graduate School, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea. + + + + Kim + Junesun + J + http://orcid.org/0000-0001-5494-4582 + + Rehabilitation Science Program, Department of Health Science, Graduate School, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea. junokim@korea.ac.kr. + + + Transdisciplinary Major in Learning Health Systems, Department of Healthcare Sciences, Graduate School, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea. junokim@korea.ac.kr. + + + Department of Physical Therapy, College of Health Science, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea. junokim@korea.ac.kr. + + + Department of Health and Environment Science, College of Health Science, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea. junokim@korea.ac.kr. + + + + eng + + + H18C1234 + the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) funded by the Ministry of Health & Welfare, Republic of Korea + + + + 2019R1I1A2A01060115 + the Basic Science Research Program funded by the Ministry of Science + + + + K2120571 + the Korea University College of Health Science + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Korea (South) + Tissue Eng Regen Med + 101699923 + 1738-2696 + + IM + + Arthritic pain + Articular cartilage + Histopathology + Monosodium iodoacetate model + Osteoarthritis + +
+ + + + 2022 + 08 + 16 + + + 2023 + 01 + 06 + + + 2022 + 12 + 14 + + + 2023 + 2 + 22 + 13 + 57 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809635 + 10.1007/s13770-023-00520-5 + 10.1007/s13770-023-00520-5 + + + + Lories RJ, Luyten FP. The bone–cartilage unit in osteoarthritis. Nat Rev Rheumatol. 2011;7:43–9. + + 21135881 + 10.1038/nrrheum.2010.197 + + + + Im HJ, Kim JS, Li X, Kotwal N, Sumner DR, van Wijnen AJ, et al. Alteration of sensory neurons and spinal response to an experimental osteoarthritis pain model. Arthritis Rheum. 2010;62:2995–3005. + + 20556813 + 2952041 + 10.1002/art.27608 + + + + Sharma L, Song J, Felson DT, Cahue S, Shamiyeh E, Dunlop DD. The role of knee alignment in disease progression and functional decline in knee osteoarthritis. JAMA. 2001;286:188–95. + + 11448282 + 10.1001/jama.286.2.188 + + + + Rakel B, Vance C, Zimmerman MB, Petsas-Blodgett N, Amendola A, Sluka KA. 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J Orthop Surg Res. 2016;11:19. + + 10.1186/s13018-016-0346-5 + + + + Schuelert N, McDougall JJ. Grading of monosodium iodoacetate-induced osteoarthritis reveals a concentration-dependent sensitization of nociceptors in the knee joint of the rat. Neurosci Lett. 2009;465:184–8. + + 19716399 + 10.1016/j.neulet.2009.08.063 + + + + Udo M, Muneta T, Tsuji K, Ozeki N, Nakagawa Y, Ohara T, et al. Monoiodoacetic acid induces arthritis and synovitis in rats in a dose-and time-dependent manner: proposed model-specific scoring systems. Osteoarthritis Cartilage. 2016;24:1284–91. + + 10.1016/j.joca.2016.02.005 + + + + Bove SE, Calcaterra SL, Brooker RM, Huber CM, Guzman RE, Juneau PL, et al. Weight bearing as a measure of disease progression and efficacy of anti-inflammatory compounds in a model of monosodium iodoacetate-induced osteoarthritis. Osteoarthritis Cartilage. 2003;11:821–30. + + 10.1016/S1063-4584(03)00163-8 + + + + Combe R, Bramwell S, Field MJ. The monosodium iodoacetate model of osteoarthritis: a model of chronic nociceptive pain in rats? Neurosci Lett. 2004;370:236–40. + + 15488329 + 10.1016/j.neulet.2004.08.023 + + + + Guzman RE, Evans MG, Bove S, Morenko B, Kilgore K. Mono-iodoacetate-induced histologic changes in subchondral bone and articular cartilage of rat femorotibial joints: an animal model of osteoarthritis. Toxicol Pathol. 2003;31:619–24. + + 14585729 + 10.1080/01926230390241800 + + + + +
+ + + 36809625 + + 2023 + 02 + 22 + +
+ + 1614-7499 + + + 2023 + Feb + 21 + + + Environmental science and pollution research international + Environ Sci Pollut Res Int + + Understanding key determinants of health climate in building construction projects. + 10.1007/s11356-023-25950-5 + + Health climate is critical for achieving a better health performance in building construction projects. However, the topic is rarely investigated by extant literature. The aim of this study is to identify key determinants of health climate in building construction projects. To achieve this goal, a hypothesis was established between practitioners' perceptions of health climate and their health status, based on a comprehensive literature review and structured interviews conducted with experienced experts. Then, a questionnaire was developed and administered for data collection. Partial least-squares structural equation modeling was used for data processing and hypothesis test. Results showed that health climate in building construction projects is positively correlated with the health status of the practitioners, and that employment involvement was the most important determinant of health climate in building construction projects, followed by management commitment, and supportive environment. Moreover, significant factors under each determinant of health climate were also disclosed. As limited research has been conducted to examine health climate in building construction projects, this study bridges the knowledge gap and is a contributory work to the current body of knowledge of construction health. Additionally, the findings of this study can provide authorities and practitioners with a deeper understanding of construction health and thereby helping them bring forward more feasible measures to improve health in building construction projects. Thus, this study is useful to the practice as well. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Li + Si-Yi + SY + + School of Civil Engineering, Central South University, 68 South Shaoshan Road, Changsha, China. + + + + Shan + Ming + M + + School of Civil Engineering, Central South University, 68 South Shaoshan Road, Changsha, China. ming.shan@csu.edu.cn. + + + + Zhai + Zhao + Z + + School of Traffic and Transportation Engineering, Changsha University of Science and Technology, 960 South Wanjiali Road, Changsha, China. + + + + eng + + + 71901224 + National Natural Science Foundation of China + + + + 2020JJ5779 + Natural Science Foundation of Hunan Province + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Environ Sci Pollut Res Int + 9441769 + 0944-1344 + + IM + + Building construction projects + China + Determinants + Health climate + +
+ + + + 2022 + 10 + 06 + + + 2023 + 02 + 10 + + + 2023 + 2 + 22 + 13 + 57 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809625 + 10.1007/s11356-023-25950-5 + 10.1007/s11356-023-25950-5 + + + References + + Barbosa C et al (2019) Occupational safety and health performance indicators in SMEs: a literature review. Work-a J Prev Assess Rehab 64(2):217–227 + + + Basen-Engquist K et al (1998) Worksite health and safety climate: scale development and effects of a health promotion intervention. Prev Med 27(1):111–119 + + 10.1006/pmed.1997.0253 + + + + Boschman JS et al (2013) Psychosocial work environment and mental health among construction workers. Appl Ergon 44(5):748–755 + + 10.1016/j.apergo.2013.01.004 + + + + Boustras G et al (2015) Management of health and safety in micro-firms in Cyprus—results from a Nationwide Survey. 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+ + + 36809627 + + 2023 + 02 + 22 + +
+ + 1614-7499 + + + 2023 + Feb + 21 + + + Environmental science and pollution research international + Environ Sci Pollut Res Int + + Vertical distribution, environmental occurrence, and risk assessment of organic pollutants in lacustrine sediments in southeast China. + 10.1007/s11356-023-25712-3 + + To clarify the impact of human activities on the natural environment, as well as the current ecological risks to the environment surrounding Zhushan Bay in Taihu Lake, the characteristics of deposited organic materials, including elements and 16 polycyclic aromatic hydrocarbons (∑16PAHs), in a sediment core from Taihu Lake were determined. The nitrogen (N), carbon (C), hydrogen (H), and sulfur (S) contents ranged from 0.08 to 0.3%, 0.83 to 3.6%, 0.63 to 1.12%, and 0.02 to 0.24%, respectively. The most abundant element in the core was C followed by H, S, and N, while elemental C and the C/H ratio displayed a decreasing trend with depth. The ∑16PAH concentration was in the range of 1807.48-4674.83 ng g-1, showing a downward trend with depth, with some fluctuations. Three-ring PAHs dominated in surface sediment, while 5-ring PAHs dominated at a depth of 55-93 cm. Six-ring PAHs appeared in the 1830s and gradually increased over time before slowly decreasing from 2005 onward due to the establishment of environmental protection measures. The ratio of PAH monomers indicated that PAHs in samples from a depth of 0 to 55 cm were mainly derived from the combustion of liquid fossil fuels, while the PAHs in the deeper samples mainly originated from petroleum. The results of a principal component analysis (PCA) showed that the PAHs in the sediment core of Taihu Lake were mainly derived from the combustion of fossil fuels, such as diesel, petroleum, gasoline, and coal. The contributions of biomass combustion, liquid fossil fuel combustion, coal combustion, and unknown source were 8.99%, 52.68%, 1.65%, and 36.68%, respectively. The results of a toxicity analysis indicated that most of the PAH monomers had little impact on the ecology, and the annual increase of a small number of monomers might have toxic effects on the biological community, resulting in a serious ecological risks, that requires the imposition of control measures. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Lang + Xiulu + X + + School of Geography, Nanjing Normal University, 1 Wenyuan Road, Nanjing, 210023, Qixia, China. + + + Key Laboratory of Virtual Geographic Environment, Ministry of Education, Nanjing Normal University, Nanjing, 210023, China. + + + Jiangsu Center for Collaborative Innovation in Geographical Information Resource Development and Application, Nanjing, 210023, China. + + + + Yu + Kangkang + K + + School of Geography, Nanjing Normal University, 1 Wenyuan Road, Nanjing, 210023, Qixia, China. + + + + Zhao + Zihan + Z + + School of Geography, Nanjing Normal University, 1 Wenyuan Road, Nanjing, 210023, Qixia, China. + + + + Chen + Yan + Y + + School of Geography, Nanjing Normal University, 1 Wenyuan Road, Nanjing, 210023, Qixia, China. + + + + Tian + Jiming + J + + School of Geography, Nanjing Normal University, 1 Wenyuan Road, Nanjing, 210023, Qixia, China. + + + + Zhang + Mingli + M + + School of Geography, Nanjing Normal University, 1 Wenyuan Road, Nanjing, 210023, Qixia, China. + + + + Wang + Yanhua + Y + http://orcid.org/0000-0001-8193-3264 + + School of Geography, Nanjing Normal University, 1 Wenyuan Road, Nanjing, 210023, Qixia, China. wangyanhua@njnu.edu.cn. + + + Key Laboratory of Virtual Geographic Environment, Ministry of Education, Nanjing Normal University, Nanjing, 210023, China. wangyanhua@njnu.edu.cn. + + + Jiangsu Center for Collaborative Innovation in Geographical Information Resource Development and Application, Nanjing, 210023, China. wangyanhua@njnu.edu.cn. + + + + eng + + + 2021YFC3201502 + National Key Research and Development Program of China + + + + 41673107 + National Natural Science Foundation of China + + + + 20KJA170001 + Major Project of the Jiangsu Provincial Department of Education + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Environ Sci Pollut Res Int + 9441769 + 0944-1344 + + IM + + Elements + Polycyclic aromatic hydrocarbons (PAHs) + Risk assessment + Sediment core + Source appointment + +
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+ + + + 2023 + 2 + 22 + 13 + 57 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809633 + 10.1007/s12275-023-00025-9 + 10.1007/s12275-023-00025-9 + + +
+ + + 36809636 + + 2023 + 02 + 22 + +
+ + 1652-7518 + + 120 + + 2023 + Feb + 21 + + + Lakartidningen + Lakartidningen + + [A patient diagnosed with MOGAD after COVID-19 - A case report]. + 22137 + + MOGAD (myelin oligodendrocyte glycoprotein antibody disease) is a newly defined inflammatory condition of the central nervous system. The presence of MOG antibodies holds a key role in the identification of the disease, as the detection of these anitbodies points to an inflammatory state with a distinct clinical presentation, specific radiological and laboratory findings, different course and prognosis as well as separate treatment considerations. Simultaneously, during the last two years healthcare worldwide has focused a large part of its resources on the management of COVID-19 patients. The long-term health effects of the infection are still unknown, but a large part of its manifestations are similar to those already seen in other viral infections.  A significant percentage of patients who develop demyelinating disorders in the central nervous system presents an acute post-infectious inflammatory process (ADEM).  Here we report the case of a young woman who presented a clinical picture compatible with ADEM after SARS-CoV-2 infection that led to a MOGAD diagnosis. + + + + Papastergios + Chrysostomos + C + + överläkare, medicinkliniken, Värnamo sjukhus. + + + + Shaker + Amen + A + + ST--läkare, medicinkliniken, Värnamo sjukhus. + + + + swe + + English Abstract + Journal Article + + MOG-positivitet i serum och likvor påvisades efter covid-19. + + 2023 + 02 + 21 + +
+ + Sweden + Lakartidningen + 0027707 + 0023-7205 + + IM +
+ + + + 2023 + 2 + 22 + 13 + 57 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809636 + 22137 + + +
+ + + 36809638 + + 2023 + 02 + 22 + +
+ + 1573-3645 + + + 2023 + Feb + 21 + + + The Journal of medical humanities + J Med Humanit + + Accidental Kindness: A Doctor's Notes on Empathy, by Michael Stein. Chapel Hill, NC: The University of North Carolina Press, 2022. + 10.1007/s10912-023-09787-0 + + + Miksanek + Tony + T + + Family Medicine, Benton, IL, USA. tmiksanek@aol.com. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + J Med Humanit + 8917478 + 1041-3545 + + IM +
+ + + + 2023 + 02 + 01 + + + 2023 + 2 + 22 + 13 + 58 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809638 + 10.1007/s10912-023-09787-0 + 10.1007/s10912-023-09787-0 + + +
+ + + 36809632 + + 2023 + 02 + 22 + +
+ + 1976-3794 + + + 2023 + Feb + 21 + + + Journal of microbiology (Seoul, Korea) + J Microbiol + + Secretions from Serratia marcescens Inhibit the Growth and Biofilm Formation of Candida spp. and Cryptococcus neoformans. + 10.1007/s12275-022-00007-3 + + Candida spp. and Cryptococcus are conditional pathogenic fungi that commonly infect immunocompromised patients. Over the past few decades, the increase in antifungal resistance has prompted the development of new antifungal agents. In this study, we explored the potential antifungal effects of secretions from Serratia marcescens on Candida spp. and Cryptococcus neoformans. We confirmed that the supernatant of S. marcescens inhibited fungal growth, suppressed hyphal and biofilm formation, and downregulated the expression of hyphae-specific genes and virulence-related genes in Candida spp. and C. neoformans. Furthermore, the S. marcescens supernatant retained biological stability after heat, pH, and protease K treatment. The chemical profile of the S. marcescens supernatant was characterized by ultra-high-performance liquid chromatography-linear ion trap/orbitrap high resolution mass spectrometry analysis and a total of 61 compounds with an mzCloud best match of greater than 70 were identified. In vivo, treatment with the S. marcescens supernatant reduced the mortality of fungi-infected Galleria mellonella. Taken together, our results revealed that the stable antifungal substances in the supernatant of S. marcescens have promising potential applications in the development of new antifungal agents. + © 2023. The Author(s), under exclusive licence to Microbiological Society of Korea. + + + + Xin + Caiyan + C + + School of Basic Medical Science, Southwest Medical University, Luzhou, 646000, People's Republic of China. + + + + Wang + Fen + F + + The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, 646000, People's Republic of China. + + + + Zhang + Jinping + J + + School of Basic Medical Science, Southwest Medical University, Luzhou, 646000, People's Republic of China. + + + Technical Platform for the Molecular Biology, Research Core Facility, Southwest Medical University, Luzhou, 646000, People's Republic of China. + + + + Zhou + Quan + Q + + School of Basic Medical Science, Southwest Medical University, Luzhou, 646000, People's Republic of China. + + + + Liu + Fangyan + F + + School of Basic Medical Science, Southwest Medical University, Luzhou, 646000, People's Republic of China. + + + + Zhao + Chunling + C + + School of Basic Medical Science, Southwest Medical University, Luzhou, 646000, People's Republic of China. 369021374@qq.com. + + + + Song + Zhangyong + Z + + School of Basic Medical Science, Southwest Medical University, Luzhou, 646000, People's Republic of China. szy83529@163.com. + + + Technical Platform for the Molecular Biology, Research Core Facility, Southwest Medical University, Luzhou, 646000, People's Republic of China. szy83529@163.com. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Korea (South) + J Microbiol + 9703165 + 1225-8873 + + IM + + Antifungal agents + Candida + Cryptococcus + Culture supernatant + Serratia marcescens + +
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+ + + 36809630 + + 2023 + 02 + 22 + +
+ + 1614-7499 + + + 2023 + Feb + 21 + + + Environmental science and pollution research international + Environ Sci Pollut Res Int + + How do country-specific R&D environments affect CCUS research performance and efficiency? From the perspective of knowledge diffusion and application. + 10.1007/s11356-023-25837-5 + + Countries around the world have set aggressive carbon emission reduction targets using various carbon reduction technologies to overcome the worsening global climate crisis. However, amid concerns among experts that such aggressive targets are difficult to achieve with existing carbon reduction technology, CCUS technology has gained recognition as an innovative technology, showing great promise in directly removing carbon dioxide and achieving carbon neutrality. This study employed a two-stage network DEA to analyze efficiency at knowledge diffusion and application stages of CCUS technology in relation to country-specific R&D environments. Based on the analysis, the following conclusions were derived. First, countries with higher standards of innovation in science and technology were more focused on quantitative R&D outcomes, making them less efficient in the diffusion and application stages. Second, countries with heavier dependence on manufacturing were less efficient in the diffusion of research outcomes due to difficulties in enforcing strong environmental-friendly policies. Lastly, countries with heavier dependence on fossil fuels were actively promoting CCUS development as a solution to carbon dioxide emissions, and such efforts were a driving factor in the diffusion and application of R&D outcomes. The significance of this study lies in analyzing the efficiency of CCUS technology in terms of knowledge diffusion and application, which are clearly distinct from a quantitative R&D efficiency analysis, thereby serving as a valuable reference in the establishment of country-specific R&D strategies for greenhouse gas reduction. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Bae + Junhee + J + + R&D Policy Department, Policy & Planning Division, Korea Institute of Geoscience and Mineral Resources (KIGAM), 124, Gwahak-ro, Yuseong-gu, Daejeon, 34132, Republic of Korea. + + + + Chun + Dongphil + D + http://orcid.org/0000-0003-1169-5197 + + Graduate school of Management of Technology, Pukyong National University, 365 Sinseon-ro, Nam-gu, Busan, 48547, Republic of Korea. performance@pknu.ac.kr. + + + + eng + + + 22-3120-1 + Korea Institute of Geoscience and Mineral Resources + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Environ Sci Pollut Res Int + 9441769 + 0944-1344 + + IM + + Carbon capture utilization storage technology + Carbon neutrality + Climate crisis + Data envelopment analysis + Knowledge application + Knowledge diffusion + +
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+ + Japan + CEN Case Rep + 101636244 + 2192-4449 + + IM + + Eosinophilic granuloma of soft tissue + Kimura disease + Minimal change nephrotic syndrome + Rituximab + +
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+ + 1559-0089 + + + 2023 + Feb + 21 + + + Neuroinformatics + Neuroinformatics + + Multimodal 3D Mouse Brain Atlas Framework with the Skull-Derived Coordinate System. + 10.1007/s12021-023-09623-9 + + Magnetic resonance imaging (MRI) and light-sheet fluorescence microscopy (LSFM) are technologies that enable non-disruptive 3-dimensional imaging of whole mouse brains. A combination of complementary information from both modalities is desirable for studying neuroscience in general, disease progression and drug efficacy. Although both technologies rely on atlas mapping for quantitative analyses, the translation of LSFM recorded data to MRI templates has been complicated by the morphological changes inflicted by tissue clearing and the enormous size of the raw data sets. Consequently, there is an unmet need for tools that will facilitate fast and accurate translation of LSFM recorded brains to in vivo, non-distorted templates. In this study, we have developed a bidirectional multimodal atlas framework that includes brain templates based on both imaging modalities, region delineations from the Allen's Common Coordinate Framework, and a skull-derived stereotaxic coordinate system. The framework also provides algorithms for bidirectional transformation of results obtained using either MR or LSFM (iDISCO cleared) mouse brain imaging while the coordinate system enables users to easily assign in vivo coordinates across the different brain templates. + © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. + + + + Perens + Johanna + J + + Gubra ApS, Hørsholm, Denmark. + + + Section for Visual Computing, Department of Applied Mathematics and Computer Science, Technical University Denmark, Kongens Lyngby, Denmark. + + + Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Amager and Hvidovre, Copenhagen, Denmark. + + + + Salinas + Casper Gravesen + CG + + Gubra ApS, Hørsholm, Denmark. + + + + Roostalu + Urmas + U + + Gubra ApS, Hørsholm, Denmark. + + + + Skytte + Jacob Lercke + JL + + Gubra ApS, Hørsholm, Denmark. + + + + Gundlach + Carsten + C + + Neutrons and X-rays for Materials Physics, Department of Physics, Technical University Denmark, Kongens Lyngby, Denmark. + + + + Hecksher-Sørensen + Jacob + J + + Gubra ApS, Hørsholm, Denmark. jhs@gubra.dk. + + + + Dahl + Anders Bjorholm + AB + + Section for Visual Computing, Department of Applied Mathematics and Computer Science, Technical University Denmark, Kongens Lyngby, Denmark. + + + + Dyrby + Tim B + TB + + Section for Visual Computing, Department of Applied Mathematics and Computer Science, Technical University Denmark, Kongens Lyngby, Denmark. + + + Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Amager and Hvidovre, Copenhagen, Denmark. + + + + eng + + + 8053- 00121B + Innovationsfonden + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Neuroinformatics + 101142069 + 1539-2791 + + IM + + Brain atlas + Crossmodal registration + Light sheet fluorescence microscopy + Magnetic resonance imaging + Multimodal imaging + Whole brain imaging + +
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+ + + 36809631 + + 2023 + 02 + 22 + +
+ + 1614-7499 + + + 2023 + Feb + 21 + + + Environmental science and pollution research international + Environ Sci Pollut Res Int + + Official Turnover and Corporate ESG Practices: Evidence from China. + 10.1007/s11356-023-25828-6 + + In recent years, environmental, social, and governance (ESG) have been extensive concerned. However, few studies have focused on the impact of situational factors on corporate ESG practice decisions. Based on this, using 9428 observations of Chinese A-share listed companies from 2009 to 2019, this paper attempts to explore the impact of local official turnover on corporate ESG practices, and analyzes the boundary effects of this impact from three aspects: region, industry, and corporate. Our results suggest that (1) official turnover can lead to changes in economic policies and redistribution of political resources, which can stimulate companies' "risk aversion motivation" and "development motivation" and thus promote their ESG practices; (2) this effect is more significant in the high degree of government intervention, the high level of industry competition and private corporates. (3) Further test finds that only when the official turnover abnormally and the regional economic development well, official turnover can significantly contribute to corporate ESG. This paper enriches the relevant research on the decision-making scenarios of corporate ESG practices from the macro-institutional perspective. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Yang + Youde + Y + + Nanjing University of Science and Technology No, 200 Xiaolingwei Street, Xuanwu District, Nanjing, Jiangsu, China. + + + + Xu + Guanghua + G + http://orcid.org/0000-0003-2873-0155 + + Nanjing University of Science and Technology No, 200 Xiaolingwei Street, Xuanwu District, Nanjing, Jiangsu, China. xgh9007286@163.com. + + + + Li + Ruiqian + R + + Heilongjiang University No, 74 Xufu Road, Nangang District, Harbin, Heilongjiang, China. + + + + eng + + + 21BGL096 + National Social Science Fund of China + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Environ Sci Pollut Res Int + 9441769 + 0944-1344 + + IM + + China + Corporate ownership + ESG + Government intervention + Industry competition + Official turnover + +
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+ + + 36809637 + + 2023 + 02 + 22 + +
+ + 1573-3645 + + + 2023 + Feb + 21 + + + The Journal of medical humanities + J Med Humanit + + Vaccine Rhetorics, by Heidi Yoston Lawrence. Columbus, OH: The Ohio State University Press, 2020. + 10.1007/s10912-023-09789-y + + + Navin + Mark C + MC + + Department of Philosophy, Mathematics and Science Center, Oakland University, 146 Library Drive, Rochester, MI, 48309-4479, USA. navin@oakland.edu. + + + Department of Foundational Medical Studies, Oakland University William Beaumont School of Medicine, Rochester, MI, USA. navin@oakland.edu. + + + Clinical Ethics Consultation Service, Department of Spiritual Care, Corewell East, Southfield, MI, USA. navin@oakland.edu. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + J Med Humanit + 8917478 + 1041-3545 + + IM +
+ + + + 2023 + 02 + 07 + + + 2023 + 2 + 22 + 13 + 58 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809637 + 10.1007/s10912-023-09789-y + 10.1007/s10912-023-09789-y + + +
+ + + 36809640 + + 2023 + 02 + 22 + +
+ + 1573-2584 + + + 2023 + Feb + 21 + + + International urology and nephrology + Int Urol Nephrol + + Prevalence of chronic kidney disease in a city of Northwestern China: a cross-sectional study. + 10.1007/s11255-023-03515-2 + + Chronic kidney disease (CKD) is increasingly recognized as a global health issue. There is a paucity of published data on the prevalence and risk factors of CKD in less-developed regions. This study aims to evaluate and update the prevalence and risk factors of CKD in a city of Northwestern China. + Based on a prospective cohort study, a cross-sectional baseline survey was conducted between 2011 and 2013. The data on the epidemiology interview, physical examination, and clinical laboratory test were all collected. In this study, 41,222 participants were selected from 48,001 workers in the baseline after excluding objects with incomplete information. The crude and standardized prevalence of CKD were calculated. An unconditional logistic regression model was used to analyze the risk factors associated with CKD among male and female. + One thousand seven hundred eighty-eight people were diagnosed with CKD, including 1180 males and 608 females. The crude prevalence of CKD was 4.34% (4.78% males and 3.68% females). The standardized prevalence was 4.06% (4.51% males and 3.60% females). The prevalence of CKD increased with age and was higher in males than in females. In multivariable logistic regression, CKD was significantly associated with the increasing age, drinking, never or occasionally exercise, overweight or obesity, being unmarried, diabetes, hyperuricemia, dyslipidemia and hypertension. + In this study, the prevalence of CKD was lower than that of the national cross-sectional study. Lifestyle, hypertension, diabetes, hyperuricemia and dyslipidemia were the main risk factors of CKD. The prevalence and risk factors differ between male and female. + © 2023. The Author(s), under exclusive licence to Springer Nature B.V. + + + + Lv + Kang + K + + Institute of Epidemiology and Statistics, School of Public Health, Lanzhou University, Lanzhou, Gansu, China. + + + + Liu + Yanli + Y + + Institute of Epidemiology and Statistics, School of Public Health, Lanzhou University, Lanzhou, Gansu, China. + + + + Zhang + Xiaofei + X + + Institute of Epidemiology and Statistics, School of Public Health, Lanzhou University, Lanzhou, Gansu, China. + + + + Wang + Minzhen + M + + Institute of Epidemiology and Statistics, School of Public Health, Lanzhou University, Lanzhou, Gansu, China. + + + + Kang + Feng + F + + Workers' Hospital of Jinchuan Group, Ltd, Jinchang, Gansu, China. + + + + Bai + Yana + Y + + Institute of Epidemiology and Statistics, School of Public Health, Lanzhou University, Lanzhou, Gansu, China. + + + + Yin + Chun + C + + Workers' Hospital of Jinchuan Group, Ltd, Jinchang, Gansu, China. + + + + Zheng + Shan + S + + Institute of Epidemiology and Statistics, School of Public Health, Lanzhou University, Lanzhou, Gansu, China. zhengsh@lzu.edu.cn. + + + + eng + + + WW2202RPZ037 + Municipal Science and Technology Program of Wuwei City, China + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Netherlands + Int Urol Nephrol + 0262521 + 0301-1623 + + IM + + Chronic kidney disease + Logistic regression + Prevalence + Risk factors + +
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+ + + 36809642 + + 2023 + 02 + 22 + +
+ + 1573-2584 + + + 2023 + Feb + 21 + + + International urology and nephrology + Int Urol Nephrol + + Treatment of localized prostate cancer in elderly patients: the role of partial cryoablation. + 10.1007/s11255-023-03519-y + + To evaluate oncological outcomes of partial gland cryoablation (PGC) for localized prostate cancer (PCa) in a cohort of elderly patients who required an active treatment. + Data from 110 consecutive patients treated with PGC for localized PCa were collected. All patients underwent the same standardized follow-up with serum-PSA level and digital rectal examination. Prostate MRI and eventual re-biopsy were performed at twelve months after cryotherapy or in case of suspicion of recurrence. Biochemical recurrence was defined according to Phoenix criteria (PSA nadir + 2 ng/ml). Kaplan-Meier curves and Multivariable Cox Regression analyses were used to predict disease progression, biochemical recurrence- (BCS) and additional treatment-free survival (TFS). + Median age was 75 years (IQR 70-79). PGC was performed in 54 (49.1%) patients with low-risk PCa, 42 (38.1%) with intermediate risk and 14 (12.8%) high risk. At a median follow-up of 36 months, we recorded a BCS and TFS of 75 and 81%, respectively. At 5 years, BCS was 68.5% and CRS 71.5%. High-risk prostate cancer was associated with lower TFS and BCS curves when compared with low-risk group (all p values < .03). A PSA reduction < 50% between preoperative level and nadir resulted as an independent failure predictor for all outcomes evaluated (all p values < .01). Age was not associated with worse outcomes. + PGC could be a valid treatment for low- to intermediate PCa in elderly patients, when a curative approach is suitable in terms of life expectancy and quality of life. + © 2023. The Author(s). + + + + Selvaggio + Oscar + O + + Department of Urology and Organ Transplantation, University of Foggia, Foggia, Italy. + + + + Finati + Marco + M + http://orcid.org/0000-0002-7425-1166 + + Department of Urology and Organ Transplantation, University of Foggia, Foggia, Italy. m.finati@outlook.it. + + + Department of Urology and Renal Transplantation, University of Foggia, Viale Pinto 1, 71110, Foggia, Italy. m.finati@outlook.it. + + + + Falagario + Ugo Giovanni + UG + + Department of Urology and Organ Transplantation, University of Foggia, Foggia, Italy. + + + + Silecchia + Giovanni + G + + Department of Urology, Bonomo Teaching Hospital, Andria (BAT), Andria, Italy. + + + + Recchia + Marco + M + + Department of Urology and Organ Transplantation, University of Foggia, Foggia, Italy. + + + + Checchia + Andrea Alberto + AA + + Department of Urology and Organ Transplantation, University of Foggia, Foggia, Italy. + + + + Milillo + Paola + P + + Department of Diagnostic Imaging, University of Foggia, Foggia, Italy. + + + + Sanguedolce + Francesca + F + + Department of Pathology, University of Foggia, Foggia, Italy. + + + + Cindolo + Luca + L + + Department of Urology, "Villa Stuart" Private Hospital, Rome, Italy. + + + + Busetto + Gian Maria + GM + + Department of Urology and Organ Transplantation, University of Foggia, Foggia, Italy. + + + + Bettocchi + Carlo + C + + Department of Urology and Organ Transplantation, University of Foggia, Foggia, Italy. + + + + Cormio + Luigi + L + + Department of Urology and Organ Transplantation, University of Foggia, Foggia, Italy. + + + Department of Urology, Bonomo Teaching Hospital, Andria (BAT), Andria, Italy. + + + + Carrieri + Giuseppe + G + + Department of Urology and Organ Transplantation, University of Foggia, Foggia, Italy. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Netherlands + Int Urol Nephrol + 0262521 + 0301-1623 + + IM + + Cryoablation + Focal therapy + Geriatric oncology + Minimally invasive surgery + Prostate cancer + +
+ + + + 2022 + 12 + 08 + + + 2023 + 02 + 13 + + + 2023 + 2 + 22 + 13 + 58 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809642 + 10.1007/s11255-023-03519-y + 10.1007/s11255-023-03519-y + + + + Mottet N, van den Bergh RCN, Briers E et al (2021) EAU-EANM-ESTRO-ESUR-SIOG guidelines on prostate cancer-2020 update. Part 1: screening, diagnosis, and local treatment with curative intent. Eur Urol 79(2):243–262. https://doi.org/10.1016/j.eururo.2020.09.042 + + 10.1016/j.eururo.2020.09.042 + 33172724 + + + + Shah TT, Peters M, Eldred-Evans D et al (2019) Early-medium-term outcomes of primary focal cryotherapy to treat nonmetastatic clinically significant prostate cancer from a prospective multicentre registry. 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+ + + 36809639 + + 2023 + 02 + 22 + +
+ + 0065-2598 + + + 2023 + Feb + 22 + + + Advances in experimental medicine and biology + Adv Exp Med Biol + + Drug Therapeutics Delivery to the Salivary Glands: Intraglandular and Intraductal Injections. + 10.1007/5584_2023_765 + + Salivary gland hypofunction and xerostomia following pathological conditions like Sjogren's syndrome or head and neck radiotherapy usually lead to tremendous impairment of oral health, speech, and swallowing. The use of systemic drugs to alleviate the symptoms of these conditions has been associated with various adverse effects. Techniques of local drug delivery to the salivary gland have grown enormously to address this problem properly. The techniques include intraglandular and intraductal injections. In this chapter, we will provide a review of the literature for both techniques while incorporating our lab experience in using them. + © 2023. The Author(s), under exclusive license to Springer Nature Switzerland AG. + + + + Almansoori + Akram Abdo + AA + + McGill Craniofacial Tissue Engineering and Stem Cells Laboratory, Faculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, QC, Canada. + + + + Hariharan + Arvind + A + + McGill Craniofacial Tissue Engineering and Stem Cells Laboratory, Faculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, QC, Canada. + + + + Cao + Uyen M N + UMN + + McGill Craniofacial Tissue Engineering and Stem Cells Laboratory, Faculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, QC, Canada. + + + + Upadhyay + Akshaya + A + + McGill Craniofacial Tissue Engineering and Stem Cells Laboratory, Faculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, QC, Canada. + + + + Tran + Simon D + SD + + McGill Craniofacial Tissue Engineering and Stem Cells Laboratory, Faculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, QC, Canada. simon.tran@mcgill.ca. + + + + eng + + Journal Article + + + 2023 + 02 + 22 + +
+ + United States + Adv Exp Med Biol + 0121103 + 0065-2598 + + IM + + Drug therapeutics + Head and neck radiotherapy + Intraductal + Intraglandular + Salivary gland + Salivary hypofunction + Sjogren’s syndrome + Xerostomia + +
+ + + + 2023 + 2 + 22 + 13 + 58 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809639 + 10.1007/5584_2023_765 + + + + Almansoori AA, Khentii N, Kim B, Kim S-M, Lee J-H (2019) Mesenchymal stem cell therapy in submandibular salivary gland allotransplantation: experimental study. Transplantation 103(6):1111–1120 + + + Antoniades D, Harrison JD, Epivatianos A, Papanayotou P (2004) Treatment of chronic sialadenitis by intraductal penicillin or saline. J Oral Maxillofac Surg 62(4):431–434 + + + Beilvert A, Faure F, Meddahi-Pellé A, Chaunier L, Guilois S, Chaubet F et al (2014) A resorbable shape-memory starch-based stent for the treatment of salivary ducts under sialendoscopic surgery. Laryngoscope 124(4):875–881 + + + Berk L (2008) Systemic pilocarpine for treatment of xerostomia. 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+ + + 36809626 + + 2023 + 02 + 22 + +
+ + 1614-7499 + + + 2023 + Feb + 21 + + + Environmental science and pollution research international + Environ Sci Pollut Res Int + + Current trends in carbon-based quantum dots development from solid wastes and their applications. + 10.1007/s11356-023-25822-y + + Urbanization and a massive population boom have immensely increased the solid wastes (SWs) generation and are expected to reach 3.40 billion tons by 2050. In many developed and emerging nations, SWs are prevalent in both major and small cities. As a result, in the current context, the reusability of SWs through various applications has taken on added importance. Carbon-based quantum dots (Cb-QDs) and their many variants are synthesized from SWs in a straightforward and practical method. Cb-QDs are a new type of semiconductor that has attracted the interest of researchers due to their wide range of applications, which include everything from energy storage, chemical sensing, to drug delivery. This review is primarily focused on the conversion of SWs into useful materials, which is an essential aspect of waste management for pollution reduction. In this context, the goal of the current review is to investigate the sustainable synthesis routes of carbon quantum dots (CQDs), graphene quantum dots (GQDs), and graphene oxide quantum dots (GOQDs) from various types SWs. The applications of CQDs, GQDs, and GOQDs in the different areas are also been discussed. Finally, the challenges in implementing the existing synthesis methods and future research directions are highlighted. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Das + Chanchal + C + http://orcid.org/0000-0002-9251-2104 + + Department of Chemistry, Cooch Behar Panchanan Barma University, West Bengal, Cooch Behar, 736101, India. + + + + Sillanpää + Mika + M + + Department of Chemical Engineering, School of Mining, Metallurgy and Chemical Engineering, University of Johannesburg, P. O. Box 17011, Doornfontein, 2028, South Africa. + + + + Zaidi + Shabi Abbas + SA + + Department of Chemistry and Earth Sciences, College of Arts and Sciences, Qatar University, 2713, Doha, Qatar. + + + + Khan + Moonis Ali + MA + http://orcid.org/0000-0002-0548-8581 + + Department of Chemistry, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia. mokhan@ksu.edu.sa. + + + + Biswas + Goutam + G + http://orcid.org/0000-0002-1488-2003 + + Department of Chemistry, Cooch Behar Panchanan Barma University, West Bengal, Cooch Behar, 736101, India. + + + + eng + + Journal Article + Review + + + 2023 + 02 + 21 + +
+ + Germany + Environ Sci Pollut Res Int + 9441769 + 0944-1344 + + IM + + Carbon quantum dots + Carbon-based quantum dots + Graphene oxide quantum dots + Graphene quantum dots + Solid wastes + +
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+ + + 36809641 + + 2023 + 02 + 22 + +
+ + 1573-2584 + + + 2023 + Feb + 21 + + + International urology and nephrology + Int Urol Nephrol + + Characteristics and 1-year survival of incident patients on chronic peritoneal dialysis compared with hemodialysis:a large 11-year cohort study. + 10.1007/s11255-023-03489-1 + + Few studies have evaluated patients' characteristics and survival by dialysis modality in Brazil. We evaluated changes in dialysis modality and its survival in the country. + This is a retrospective database of a cohort with incident chronic dialysis patients from Brazil. Patients' characteristics and one-year multivariate survival risk were assessed considering dialysis modality from 2011 to 2016 and 2017 to 2021. Survival analysis was also performed on a reduced sample after adjustment using propensity score matching. + Of the 8295 dialysis patients, 5.3% were on peritoneal dialysis (PD) and 94.7% on hemodialysis (HD). PD patients had higher BMI, schooling and the prevalence of elective dialysis starting in the first period than those on HD. In the second period, PD patients were predominantly women, non-white, from the Southeast region, and funded by the public health system, having more frequent elective dialysis starting and predialysis nephrologist follow-ups than those on HD. There was no difference in mortality comparing PD and HD (HR 0.67, 95% CI 0.39-2.42; and HR 1.17, 95% CI 0.63-2.16; first and second period, respectively). This non-significantly different survival between both dialysis methods was also found in the reduced matched sample. Higher age and non-elective dialysis initiation were associated with higher mortality. In the second period, the lack of predialysis nephrologist follow-up and living in the Southeast region increased the mortality risk. + Some sociodemographic factors have changed according to dialysis modality over the last decade in Brazil. The one-year survival of the two dialysis methods was comparable. + © 2023. The Author(s), under exclusive licence to Springer Nature B.V. + + + + do Nascimento Lima + Helbert + H + http://orcid.org/0000-0003-0081-6897 + + Department of Medicine, University of the Region of Joinville, Rua Rio do Sul, 270, Joinville, Santa Catarina, CEP 89202-201, Brazil. helbertlima@hotmail.com. + + + + Nerbass + Fabiana Baggio + FB + + Pró Rim Fundation, Joinville, Brazil. + + + + Lugon + Jocemir Ronaldo + JR + + Nephrology Division, Department of Medicine, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil. + + + + Sesso + Ricardo + R + + Nephrology Division, Federal University of São Paulo State, São Paulo, Brazil. + + + + Brazilian Dialysis Register Investigators + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
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+ + + 36809654 + + 2023 + 02 + 22 + +
+ + 1478-596X + + + 2023 + Feb + 21 + + + The international journal of medical robotics + computer assisted surgery : MRCAS + Int J Med Robot + + A venipuncture robot with decoupled position and attitude guided by near-infrared vision and force feedback. + + e2512 + + 10.1002/rcs.2512 + + This study aims to develop a venipuncture robot to replace manual venipuncture to ease the heavy workload, lower the risk of 2019-nCoV infection, and boost venipuncture success rates. + The robot is designed with decoupled position and attitude. It consists of a 3-degree-of-freedom positioning manipulator to locate the needle and a 3-degree-of-freedom end-effector that is always vertical to adjust the yaw and pitch angles of the needle. The near-infrared vision and laser sensors obtain the three-dimensional information of puncture positions, while the change in force detects the state feedback of punctures. + The experimental results demonstrate that the venipuncture robot has a compact design, flexible motion, high positioning accuracy and repeatability (0.11 mm and 0.04 mm), and a high success rate when puncturing the phantom. + This paper presents a decoupled position and attitude venipuncture robot guided by near-infrared vision and force feedback to replace manual venipuncture. The robot is compact, dexterous, and accurate, which helps to improve the success rate of venipuncture, and it is expected to achieve fully automatic venipuncture in the future. This article is protected by copyright. All rights reserved. + This article is protected by copyright. All rights reserved. + + + + He + Tianbao + T + + State Key Laboratory of Robotics and System, Harbin Institute of Technology, Harbin, 150001, China. + + + + Guo + Chuangqiang + C + + State Key Laboratory of Robotics and System, Harbin Institute of Technology, Harbin, 150001, China. + + + + Liu + Hansong + H + + State Key Laboratory of Robotics and System, Harbin Institute of Technology, Harbin, 150001, China. + + + + Jiang + Li + L + + State Key Laboratory of Robotics and System, Harbin Institute of Technology, Harbin, 150001, China. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Int J Med Robot + 101250764 + 1478-5951 + + IM + + decoupled position and attitude + force feedback + near-infrared vision + venipuncture robot + +
+ + + + 2022 + 12 + 27 + + + 2022 + 11 + 02 + + + 2023 + 02 + 16 + + + 2023 + 2 + 22 + 13 + 59 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809654 + 10.1002/rcs.2512 + + +
+ + + 36809644 + + 2023 + 02 + 22 + +
+ + 1573-3327 + + + 2023 + Feb + 21 + + + Child psychiatry and human development + Child Psychiatry Hum Dev + + Positive and Negative Life Events in Association with Psychopathology: An Examination of Sex Differences in Early Adolescence. + 10.1007/s10578-023-01509-w + + Negative life events (NLEs) are associated with psychopathology in older adolescents and adults, particularly for women. However, less is known about the association between positive life events (PLEs) and psychopathology. This study examined associations between NLEs, PLEs, and their interaction, and sex differences in associations between PLEs and NLEs on internalizing and externalizing psychopathology. Youth completed interviews about NLEs and PLEs. Parents and youth reported on youth internalizing and externalizing symptoms. NLEs were positively associated with youth-reported depression and anxiety and parent-reported youth depression. Female youth had stronger positive associations between NLEs and youth-reported anxiety than male youth. Interactions between PLEs and NLEs were non-significant. Findings for NLEs and psychopathology are extended to earlier in development. + © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. + + + + Madhavan + Subhashini + S + + Department of Psychology, Temple University, 1701 North 13th Street, Weiss Hall, Philadelphia, PA, United States. + + + + Stewart + Lindsey C + LC + + Department of Psychology, Temple University, 1701 North 13th Street, Weiss Hall, Philadelphia, PA, United States. + + + + Birk + Samantha L + SL + + Department of Psychology, Temple University, 1701 North 13th Street, Weiss Hall, Philadelphia, PA, United States. + + + + Nielsen + Johanna D + JD + + Department of Psychology, Temple University, 1701 North 13th Street, Weiss Hall, Philadelphia, PA, United States. + + + + Olino + Thomas M + TM + + Department of Psychology, Temple University, 1701 North 13th Street, Weiss Hall, Philadelphia, PA, United States. thomas.olino@temple.edu. + + + + eng + + + R01 MH107495 + National Institutes of Health + + + + R01 MH107495 + National Institutes of Health + + + + R01 MH107495 + National Institutes of Health + + + + R01 MH107495 + National Institutes of Health + + + + R01 MH107495 + National Institutes of Health + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Child Psychiatry Hum Dev + 1275332 + 0009-398X + + IM + + Biological sex + Negative life events + Positive life events + Psychopathology + +
+ + + + 2023 + 02 + 09 + + + 2023 + 2 + 22 + 13 + 58 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809644 + 10.1007/s10578-023-01509-w + 10.1007/s10578-023-01509-w + + + + Richardson CME (2017) Emotion regulation in the context of daily stress: impact on Daily Affect. Personal Individ Differ 112:150–156 + + 10.1016/j.paid.2017.02.058 + + + + Baddam SKR, Olvera RL, Canapari CA, Crowley MJ, Williamson DE (2019) Childhood Trauma and Stressful Life events are independently Associated with Sleep Disturbances in adolescents. Behav Sci 9(10):108 + + 31658779 + 6826433 + 10.3390/bs9100108 + + + + McMahon G, Creaven AM, Gallagher S (2020) Stressful life events and adolescent Well-Being: the role of parent and peer Relationships. 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J Anxiety Disord 26(8):785–791 + + 23023158 + 10.1016/j.janxdis.2012.07.008 + + + + Achenbach TM (2001) Manual for ASEBA school-age forms & profiles. Univ Vt Res Cent Child Youth Fam + + + Achenbach TM, Edelbrock CS (1979) The child Behavior Profile: II. Boys aged 12–16 and girls aged 6–11 and 12–16. J Consult Clin Psychol 47(2):223 + + 469068 + 10.1037/0022-006X.47.2.223 + + + + Youngstrom E, Loeber R, Stouthamer-Loeber M (2000) Patterns and correlates of agreement between parent, teacher, and male adolescent ratings of externalizing and internalizing problems. J Consult Clin Psychol 68(6):1038–1050 + + 11142538 + 10.1037/0022-006X.68.6.1038 + + + + Hudziak JJ, Copeland W, Stanger C, Wadsworth M (2004) Screening for DSM-IV Externalizing Disorders with the child Behavior Checklist: a receiver-operating characteristic analysis. J Child Psychol Psychiatry 45(7):1299–1307 + + 15335349 + 10.1111/j.1469-7610.2004.00314.x + + + + Ebesutani C, Bernstein A, Nakamura BJ, Chorpita BF, Higa-McMillan CK, Weisz JR et al (2010) Concurrent validity of the child Behavior Checklist DSM-Oriented Scales: correspondence with DSM Diagnoses and comparison to Syndrome Scales. J Psychopathol Behav Assess 32(3):373–384 + + 20700377 + 10.1007/s10862-009-9174-9 + + + + Seligman LD, Ollendick TH, Langley AK, Baldacci HB (2004) The utility of measures of child and adolescent anxiety: a Meta-Analytic Review of the revised children’s manifest anxiety scale, the state–trait anxiety inventory for children, and the child Behavior Checklist. J Clin Child Adolesc Psychol 33(3):557–565 + + 15271613 + 10.1207/s15374424jccp3303_13 + + + + Aiken LS, West SG, Reno RR (1991) Multiple regression: testing and interpreting interactions. SAGE, p 228 + + + Muthén LK, Muthén BO (1998) –2012 Mplus User’s Guide; Seventh Edition + + + Hallquist MN, Wiley JF (2018) MplusAutomation: an R Package for Facilitating large-scale latent variable analyses in Mplus. Struct Equ Model Multidiscip J 25(4):621–638 + + 10.1080/10705511.2017.1402334 + + + + Asselmann E, Wittchen HU, Lieb R, Höfler M, Beesdo-Baum K (2015) Danger and loss events and the incidence of anxiety and depressive Disorders: a prospective-longitudinal community study of adolescents and young adults. Psychol Med 45(1):153–163 + + 25065411 + 10.1017/S0033291714001160 + + + + Braet C, Vlierberghe LV, Vandevivere E, Theuwis L, Bosmans G (2013) Depression in Early, Middle and late adolescence: Differential evidence for the cognitive diathesis–stress model. Clin Psychol Psychother 20(5):369–383 + + 22473794 + + + + Choudhury MS, Pimentel SS, Kendall PC (2003) Childhood anxiety Disorders: parent–child (Dis) Agreement using a structured interview for the DSM-IV. J Am Acad Child Adolesc Psychiatry 42(8):957–964 + + 12874498 + 10.1097/01.CHI.0000046898.27264.A2 + + + + Grills AE, Ollendick TH (2003) Multiple informant agreement and the anxiety Disorders interview schedule for parents and children. J Am Acad Child Adolesc Psychiatry 42(1):30–40 + + 12500074 + 10.1097/00004583-200301000-00008 + + + + Rothen S, Vandeleur CL, Lustenberger Y, Jeanprêtre N, Ayer E, Gamma F et al (2009) Parent–child agreement and prevalence estimates of Diagnoses in Childhood: direct interview Versus Family History Method. Int J Methods Psychiatr Res 18(2):96–109 + + 19507167 + 6878311 + 10.1002/mpr.281 + + + + Salbach-Andrae H, Klinkowski N, Lenz K, Lehmkuhl U (2009) Agreement between Youth-Reported and parent-reported psychopathology in a referred sample. Eur Child Adolesc Psychiatry 18(3):136–143 + + 19129966 + 10.1007/s00787-008-0710-z + + + + Hankin BL, Abramson LY, Moffitt TE, Silva PA, McGee R, Angell KE (1998) Development of Depression from Preadolescence to Young Adulthood: emerging gender differences in a 10-Year longitudinal study. J Abnorm Psychol 107:128–140 + + 9505045 + 10.1037/0021-843X.107.1.128 + + + + Cougle JR, Timpano KR, Sachs-Ericsson N, Keough ME, Riccardi CJ (2010) Examining the Unique Relationships between anxiety Disorders and Childhood Physical and sexual abuse in the National Comorbidity Survey-Replication. Psychiatry Res 177(1):150–155 + + 20381878 + 10.1016/j.psychres.2009.03.008 + + + + Francis JL, Moitra E, Dyck I, Keller MB (2012) The impact of Stressful Life events on relapse of generalized anxiety disorder. Depress Anxiety 29(5):386–391 + + 22431499 + 3667630 + 10.1002/da.20919 + + + + Cohen LH, McGowan J, Fooskas S, Rose S (1984) Positive life events and social support and the relationship between life stress and psychological disorder. Am J Community Psychol 12(5):567–587 + + 6496413 + 10.1007/BF00897213 + + + + Shahar G, Priel B (2002) Positive life events and adolescent emotional distress: in search of protective-interactive processes. J Soc Clin Psychol 21(6):645–668 + + 10.1521/jscp.21.6.645.22798 + + + + Brewin CR, Andrews B, Gotlib IH (1993) Psychopathology and early experience: a reappraisal of Retrospective Reports. Psychol Bull 113(1):82–98 + + 8426875 + 10.1037/0033-2909.113.1.82 + + + + +
+ + + 36809655 + + 2023 + 02 + 22 + +
+ + 1935-9780 + + + 2023 + Feb + 21 + + + Anatomical sciences education + Anat Sci Educ + + Analysis of Statements in Documents of Gift for Academic Body Donation Programs in the United States, and Recommendations for Future Practice. + 10.1002/ase.2263 + + In United States (U.S.) anatomical gift law, the record on which a person consents to body donation after death is referred to as a document of gift (DG). Due to the lack of legal requirements around minimum information standards, enacted recommendations in the U.S., and the unknown variation across extant DGs, a review of publicly-available DGs from U.S. academic body donation programs was performed to benchmark existing statements and recommend specific foundational content for all U.S. DGs. From 117 body donor programs identified, 93 DGs were downloaded (median length three pages, range 1-20). Statements within the DG were qualitatively categorized into 60 codes within eight themes (Communication, Eligibility, Terms of Use, Logistics, Legal References, Financials, Final Disposition, Signatures), using existing recommendations of academics, ethicists, and professional associations to guide analysis. From 60 codes, 12 had high disclosure rates (67-100% of DGs included; e.g., donor personal information), 22 had moderate rates (34-66%; e.g., discretion to decline a body), and 26 had low disclosure rates (1-33%; e.g., testing bodies for disease). Some codes with the lowest disclosure frequency were those previously recommended as necessary. Findings highlighted substantial variation in DG statements, with a higher number of baseline disclosure statements than previously recommended. These results present an opportunity to better understand disclosures that have importance for programs and donors alike. Recommendations suggest minimum standards of informed consent practices for body donation programs in the U.S. These include clarity around consent processes, consistency of language, and minimum operational standards for informed consent. + This article is protected by copyright. All rights reserved. + + + + Johnson + Laura E + LE + https://orcid.org/0000-0003-4396-9172 + + Department of Cell Systems and Anatomy, Joe R. and Teresa Long School of Medicine, University of Texas Health San Antonio, San Antonio, Texas. + + + + McArthur + Angela + A + + Anatomy Bequest Program, University of Minnesota Medical School, Minneapolis, Minnesota. + + + + Schmitt + Brandi + B + + Office of the President, University of California, Oakland, California. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + Anat Sci Educ + 101392205 + 1935-9772 + + IM + + Anatomical gift + body donation + consent + document of gift + informed consent + +
+ + + + 2023 + 02 + 14 + + + 2022 + 08 + 03 + + + 2023 + 02 + 15 + + + 2023 + 2 + 22 + 13 + 59 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809655 + 10.1002/ase.2263 + + +
+ + + 36809653 + + 2023 + 02 + 22 + +
+ + 1399-0012 + + + 2023 + Feb + 21 + + + Clinical transplantation + Clin Transplant + + Impact of Converting Adult Kidney Transplant Recipients with High Tacrolimus Variability from Twice Daily Immediate Release Tacrolimus to Once Daily LCP-Tacrolimus. + + e14941 + + 10.1111/ctr.14941 + + The influence of converting to once daily, extended-release LCP-Tacrolimus (Tac) for those with high tacrolimus variability in kidney transplant recipients (KTRs) is not well-studied. + Single-center, retrospective cohort study of adult KTRs converted from Tac immediate release to LCP-Tac 1-2 years post-transplant. Primary measures were tac variability, using the coefficient of variation (CV) and time in therapeutic range (TTR), as well as clinical outcomes (rejection, infections, graft loss, death). + 193 KTRs included with a follow-up of 3.2±0.7 years and 1.3±0.3 years since LCP-Tac conversion. Mean age was 52±13 years; 70% were African American, 39% were female, 16% living donor and 12% donor after cardiac death (DCD). In the overall cohort, tac CV was 29.5% before conversion, which increased to 33.4% after LCP-Tac (p = 0.008). In those with Tac CV >30% (n = 86), conversion to LCP-Tac reduced variability (40.6%vs. 35.5%; p = 0.019) and for those with Tac CV >30% and nonadherence or med errors (n = 16), LCP-Tac conversion substantially reduced Tac CV (43.4% vs 29.9%; p = 0.026). TTR significantly improved for those with Tac CV >30% with (52.4% vs. 82.8%; p = 0.027) or without nonadherence or med errors (64.8% vs. 73.2%; p = 0.005). CMV, BK, and overall infections were significantly higher prior to LCP-Tac conversion. In the overall cohort, 3% had rejection before conversion and 2% after (p = NS). At end of follow-up, graft and patient survival were 94% and 96%, respectively. + In those with high Tac CV, conversion to LCP-Tac is associated with a significant reduction in variability and improvement in TTR, particularly in those with nonadherence or medication errors. This article is protected by copyright. All rights reserved. + This article is protected by copyright. All rights reserved. + + + + Taber + David J + DJ + https://orcid.org/0000-0001-7273-4589 + + Department of Surgery, Division of Transplant Surgery, MUSC, Charleston, SC. + + + + Bartlett + Felicia + F + + Department of Pharmacy Services, MUSC, Charleston, SC. + + + + Patel + Neha + N + https://orcid.org/0000-0002-8181-9442 + + Department of Pharmacy Services, MUSC, Charleston, SC. + + + + Sprague + Taylor + T + + Department of Pharmacy Services, MUSC, Charleston, SC. + + + + Patel + Shikha + S + https://orcid.org/0000-0001-9480-5405 + + Department of Pharmacy Services, MUSC, Charleston, SC. + + + + Newman + Jessica + J + + Department of Pharmacy Services, MUSC, Charleston, SC. + + + + Andrade + Erika + E + + College of Medicine, MUSC, Charleston, SC. + + + + Rao + Nikhil + N + + Department of Surgery, Division of Transplant Surgery, MUSC, Charleston, SC. + + + + Salas + Maria Aurora Posadas + MAP + https://orcid.org/0000-0001-7411-7154 + + Department of Medicine, Division of Nephrology, MUSC, Charleston, SC. + + + + Casey + Michael + M + + Department of Medicine, Division of Nephrology, MUSC, Charleston, SC. + + + + Dubay + Derek + D + + Department of Surgery, Division of Transplant Surgery, MUSC, Charleston, SC. + + + + Rohan + Vinayak + V + + Department of Surgery, Division of Transplant Surgery, MUSC, Charleston, SC. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Denmark + Clin Transplant + 8710240 + 0902-0063 + + IM +
+ + + + 2023 + 01 + 14 + + + 2022 + 07 + 08 + + + 2023 + 02 + 08 + + + 2023 + 2 + 22 + 13 + 59 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809653 + 10.1111/ctr.14941 + + +
+ + + 36809651 + + 2023 + 02 + 22 + +
+ + 1096-987X + + + 2023 + Feb + 21 + + + Journal of computational chemistry + J Comput Chem + + GalaxyDock2-HEME: Protein-ligand docking for heme proteins. + 10.1002/jcc.27092 + + Prediction of protein-ligand binding poses is an essential component for understanding protein-ligand interactions and computer-aided drug design. Various proteins involve prosthetic groups such as heme for their functions, and adequate consideration of the prosthetic groups is vital for protein-ligand docking. Here, we extend the GalaxyDock2 protein-ligand docking algorithm to handle ligand docking to heme proteins. Docking to heme proteins involves increased complexity because the interaction of heme iron and ligand has covalent nature. GalaxyDock2-HEME, a new protein-ligand docking program for heme proteins, has been developed based on GalaxyDock2 by adding an orientation-dependent scoring term to describe heme iron-ligand coordination interaction. This new docking program performs better than other noncommercial docking programs such as EADock with MMBP, AutoDock Vina, PLANTS, LeDock, and GalaxyDock2 on a heme protein-ligand docking benchmark set in which ligands are known to bind iron. In addition, docking results on two other sets of heme protein-ligand complexes in which ligands do not bind iron show that GalaxyDock2-HEME does not have a high bias toward iron binding compared to other docking programs. This implies that the new docking program can distinguish iron binders from noniron binders for heme proteins. + © 2023 Wiley Periodicals LLC. + + + + Lee + Changsoo + C + + Department of Chemistry, Seoul National University, Seoul, Republic of Korea. + + + + Yang + Jinsol + J + + Galux Inc, Gwanak-gu, Seoul, Republic of Korea. + + + + Kwon + Sohee + S + https://orcid.org/0000-0003-3447-4610 + + Galux Inc, Gwanak-gu, Seoul, Republic of Korea. + + + + Seok + Chaok + C + https://orcid.org/0000-0002-1419-9888 + + Department of Chemistry, Seoul National University, Seoul, Republic of Korea. + + + Galux Inc, Gwanak-gu, Seoul, Republic of Korea. + + + + eng + + + National Research Foundation of Korea + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + United States + J Comput Chem + 9878362 + 0192-8651 + + IM + + coordination bond potential + energy parameter optimization + heme proteins + protein-ligand docking + +
+ + + + 2023 + 01 + 20 + + + 2022 + 11 + 01 + + + 2023 + 02 + 08 + + + 2023 + 2 + 22 + 13 + 59 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809651 + 10.1002/jcc.27092 + + + REFERENCES + + W. J. Lennarz, M. D. Lane, Encyclopedia of biological chemistry, Academic Press, London, UK, 2013. + + + T. Lynch, A. P. Neff, Am. Fam. Physician 2007, 76, 391. + + + A. J. Hobbs, A. Higgs, S. Moncada, Annu. Rev. Pharmacol. Toxicol. 1999, 39, 191. + + + A. M. Brodie, V. C. Njar, Steroids 2000, 65, 171. + + + T. Lengauer, M. Rarey, Curr. Opin. Struct. Biol. 1996, 6, 402. + + + X. Y. Meng, H. X. Zhang, M. Mezei, M. Cui, Curr. Comput. Aided Drug Des. 2011, 7, 146. + + + I. D. Kuntz, J. M. Blaney, S. J. Oatley, R. Langridge, T. E. Ferrin, J. Mol. Biol. 1982, 161, 269. + + + G. Wang, W. Zhu, Future Med. Chem. 2016, 8, 1707. + + + M. Thomas, R. T. Smith, N. M. O'Boyle, C. de Graaf, A. Bender, J. Chem. 2021, 13, 1. + + + J. Jumper, R. Evans, A. Pritzel, T. Green, M. 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Park, C. Yoon, J. H. Lee, C. Seok, J. Chem. Inf. Model. 2020, 60(6), 3246. + + + L. Heo, S. Park, C. Seok, J. Chem. Inf. Model. 2021, 61(5), 2283. + + + S. Park, C. Seok, J. Chem. Inf. Model. 2022, 62(13), 3157. + + + +
+ + + 36809649 + + 2023 + 02 + 22 + +
+ + 2212-1358 + + + 2023 + Feb + 21 + + + Spine deformity + Spine Deform + + Alberto Ponte, MD : July 9, 1926-January 10, 2023. + 10.1007/s43390-023-00655-4 + + + Shapiro + Jay + J + + University Hospitals Cleveland Medical Center, Cleveland, USA. + + + + Thompson + George H + GH + + University Hospitals Cleveland Medical Center, Cleveland, USA. george.thompson@uhhospitals.org. + + + + Akbarnia + Behrooz A + BA + + University Hospitals Cleveland Medical Center, Cleveland, USA. + + + + eng + + Editorial + + + 2023 + 02 + 21 + +
+ + England + Spine Deform + 101603979 + 2212-134X + + IM +
+ + + + 2023 + 2 + 22 + 13 + 59 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809649 + 10.1007/s43390-023-00655-4 + 10.1007/s43390-023-00655-4 + + +
+ + + 36809647 + + 2023 + 02 + 22 + +
+ + 2240-2993 + + + 2023 + Feb + 21 + + + Acta neurologica Belgica + Acta Neurol Belg + + Anti-spastic effect of contralesional dorsal premotor cortex stimulation in stroke patients with moderate-to-severe spastic paresis: a randomized, controlled pilot trial. + 10.1007/s13760-023-02212-2 + + This study aimed at investigating the effect of a single-session repetitive transcranial magnetic stimulation (rTMS) of the contralesional dorsal premotor cortex on poststroke upper-limb spasticity. + The study consisted of the following three independent parallel arms: inhibitory rTMS (n = 12), excitatory rTMS (n = 12), and sham stimulation (n = 13). The primary and secondary outcome measures were the Modified Ashworth Scale (MAS) and F/M amplitude ratio, respectively. A clinically meaningful difference was defined as a reduction in at least one MAS score. + There was a statistically significant change in MAS score within only the excitatory rTMS group over time [median (interquartile range) of - 1.0 (- 1.0 to - 0.5), p = 0.004]. However, groups were comparable in terms of median changes in MAS scores (p > 0.05). The proportions of patients achieving at least one MAS score reduction (9/12 in the excitatory rTMS group, 5/12 in the inhibitory rTMS group, and 5/13 in the control group) were also comparable (p = 0.135). For the F/M amplitude ratio, main time effect, main intervention effect, and time-intervention interaction effect were not statistically significant (p > 0.05). + Modulation of the contralesional dorsal premotor cortex with a single-session of excitatory or inhibitory rTMS does not appear to have an immediate anti-spastic effect beyond sham/placebo. The implication of this small study remains unclear and further studies into excitatory rTMS for the treatment of moderate-to-severe spastic paresis in poststroke patients should be undertaken. + NCT04063995 (clinicaltrials.gov). + © 2023. The Author(s) under exclusive licence to Belgian Neurological Society. + + + + Şengül + İlker + İ + http://orcid.org/0000-0002-7675-7814 + + Department of Physical Medicine and Rehabilitation, School of Medicine, İzmir Kâtip Çelebi University, Basın Sitesi Mahallesi Gazeteci Hasan Tahsin Caddesi, İzmir, Turkey. ilkrsngl@gmail.com. + + + + Aşkın + Ayhan + A + + Department of Physical Medicine and Rehabilitation, School of Medicine, İzmir Kâtip Çelebi University, Basın Sitesi Mahallesi Gazeteci Hasan Tahsin Caddesi, İzmir, Turkey. + + + + Altun + Aylin + A + + Department of Physical Medicine and Rehabilitation, School of Medicine, İzmir Kâtip Çelebi University, Basın Sitesi Mahallesi Gazeteci Hasan Tahsin Caddesi, İzmir, Turkey. + + + + Tosun + Aliye + A + + Department of Physical Medicine and Rehabilitation, School of Medicine, İzmir Kâtip Çelebi University, Basın Sitesi Mahallesi Gazeteci Hasan Tahsin Caddesi, İzmir, Turkey. + + + + eng + + + ClinicalTrials.gov + + NCT04063995 + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Italy + Acta Neurol Belg + 0247035 + 0300-9009 + + IM + + Dorsal premotor cortex + Muscle spasticity + Repetitive transcranial magnetic stimulation + Stroke + +
+ + + + 2022 + 08 + 25 + + + 2023 + 02 + 12 + + + 2023 + 2 + 22 + 13 + 59 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809647 + 10.1007/s13760-023-02212-2 + 10.1007/s13760-023-02212-2 + + + + Lance JW (1980) Symposium synopsis. In: Feldman RG, Young RR, Koella WP (eds) Spasticity: disordered motor control. Yearbook Medical, Chicago, pp 485–494 + + + Gracies JM (2005) Pathophysiology of spastic paresis. II: Emergence of muscle overactivity. Muscle Nerve 31:552–571 + + 15714511 + 10.1002/mus.20285 + + + + Opheim A, Danielsson A, Alt Murphy M, Persson HC, Sunnerhagen KS (2014) Upper-limb spasticity during the first year after stroke: stroke arm longitudinal study at the University of Gothenburg. Am J Phys Med Rehabil 93:884–896 + + 25180838 + 10.1097/PHM.0000000000000157 + + + + Francisco G, McGuire JRJ (2012) Poststroke spasticity management. 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+ + + 36809650 + + 2023 + 02 + 22 + +
+ + 1521-4095 + + + 2023 + Feb + 21 + + + Advanced materials (Deerfield Beach, Fla.) + Adv Mater + + Genetically Engineering Cell Membrane-Coated BTO Nanoparticles for MMP2-activated Piezocatalysis-immunotherapy. + + e2300964 + + 10.1002/adma.202300964 + + Tumor immunotherapy based on immune checkpoint blockade (ICB) still suffers from low host response rate and non-specific distribution of immune checkpoint inhibitors, greatly compromising the therapeutic efficiency. Herein, cellular membrane stably expressing matrix metallopeptidase 2 (MMP2)-activated PD-L1 blockades was engineered to coat ultrasmall barium titanate (BTO) nanoparticle for overcoming the immunosuppressive microenvironment of tumors. The resulting M@BTO NPs can significantly promote the BTO's tumor accumulation, while the masking domains on membrane PD-L1 antibodies were cleaved when exposure to MMP2 highly expressed in tumor. With ultrasound irradiation, M@BTO NPs can simultaneously generate reactive oxygen species (ROS) and O2 based on BTO mediated piezocatalysis and water splitting, significantly promoting the intratumoral infiltration of cytotoxic T lymphocytes (CTLs) and improving the PD-L1 blockade therapy to the tumor, resulting in effective tumor growth inhibition and lung metastasis suppression in a melanoma mouse model. This nanoplatform combined MMP2-activated genetic editing cell membrane with US responsive BTO for both immune stimulation and specific PD-L1 inhibition, providing a safe and robust strategy in enhancing immune response against tumor. This article is protected by copyright. All rights reserved. + This article is protected by copyright. All rights reserved. + + + + Tang + Qingshuang + Q + + Department of Ultrasound, Peking University Third Hospital, Beijing, 100191, China. + + + + Sun + Suhui + S + + Department of Ultrasound, Peking University Third Hospital, Beijing, 100191, China. + + + + Wang + Ping + P + + Department of Ultrasound, Peking University Third Hospital, Beijing, 100191, China. + + + + Sun + Lihong + L + + Department of Ultrasound, Peking University Third Hospital, Beijing, 100191, China. + + + + Wang + Yuan + Y + + Department of Ultrasound, Peking University Third Hospital, Beijing, 100191, China. + + + + Zhang + Lulu + L + + Department of Ultrasound, Peking University Third Hospital, Beijing, 100191, China. + + + + Xu + Menghong + M + + Department of Ultrasound, Peking University Third Hospital, Beijing, 100191, China. + + + + Chen + Jing + J + + Department of Ultrasound, Peking University Third Hospital, Beijing, 100191, China. + + + + Wu + Ruiqi + R + + Department of Ultrasound, Peking University Third Hospital, Beijing, 100191, China. + + + + Zhang + Jinxia + J + + Department of Ultrasound, Peking University Third Hospital, Beijing, 100191, China. + + + + Gong + Ming + M + + Department of Ultrasound, Peking University Third Hospital, Beijing, 100191, China. + + + + Chen + Qingfeng + Q + + Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore. + + + + Liang + Xiaolong + X + https://orcid.org/0000-0001-7299-3329 + + Department of Ultrasound, Peking University Third Hospital, Beijing, 100191, China. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Germany + Adv Mater + 9885358 + 0935-9648 + + IM + + MMP2 + cancer immunotherapy + drug delivery + gene engineering + immune checkpoint blockades + piezocatalysis + +
+ + + + 2023 + 01 + 31 + + + 2023 + 2 + 22 + 13 + 59 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809650 + 10.1002/adma.202300964 + + +
+ + + 36809648 + + 2023 + 02 + 22 + +
+ + 2212-1358 + + + 2023 + Feb + 21 + + + Spine deformity + Spine Deform + + Anterior vertebral body tethering for adolescent idiopathic scoliosis associated with less early post-operative pain and shorter recovery compared with fusion. + 10.1007/s43390-023-00661-6 + + While posterior spinal instrumentation and fusion (PSIF) for severe adolescent idiopathic scoliosis (AIS) is the gold standard, anterior vertebral body tethering (AVBT) is becoming an alternative for select cases. Several studies have compared technical outcomes for these two procedures, but no studies have compared post-operative pain and recovery. + In this prospective cohort, we evaluated patients who underwent AVBT or PSIF for AIS for a period of 6 weeks after operation. Pre-operative curve data were obtained from the medical record. Post-operative pain and recovery were evaluated with pain scores, pain confidence scores, PROMIS scores for pain behavior, interference, and mobility, and functional milestones of opiate use, independence in activities of daily living (ADLs), and sleeping. + The cohort included 9 patients who underwent AVBT and 22 who underwent PSIF, with a mean age of 13.7 years, 90% girls, and 77.4% white. The AVBT patients were younger (p = 0.03) and had fewer instrumented levels (p = 0.03). Results were significant for decreased pain scores at 2 and 6 weeks after operation (p = 0.004, and 0.030), decreased PROMIS pain behavior at all time points (p = 0.024, 0.049, and 0.001), decreased pain interference at 2 and 6 weeks post-operative (p = 0.012 and 0.009), increased PROMIS mobility scores at all time points (p = 0.036, 0.038, and 0.018), and faster time to functional milestones of weaning opiates, independence in ADLs, and sleep (p = 0.024, 0.049, and 0.001). + In this prospective cohort study, the early recovery period following AVBT for AIS is characterized by less pain, increased mobility, and faster recovery of functional milestones, compared with PSIF. + IV. + © 2023. The Author(s). + + + + O'Donnell + Jennifer M + JM + http://orcid.org/0000-0002-9509-506X + + Department of Orthopaedic Surgery, University of California San Francisco, 505 Parnassus Ave MU 320W, San Francisco, CA, 94143, USA. Jennifer.odonnell@ucsf.edu. + + + + Gornitzky + Alex L + AL + + Department of Orthopaedic Surgery, University of California San Francisco, 505 Parnassus Ave MU 320W, San Francisco, CA, 94143, USA. + + + + Wu + Hao-Hua + HH + + Department of Orthopaedic Surgery, University of California San Francisco, 505 Parnassus Ave MU 320W, San Francisco, CA, 94143, USA. + + + + Furie + Kira S + KS + + University of California San Francisco School of Medicine, San Francisco, CA, 94143, USA. + + + + Diab + Mohammad + M + + Department of Orthopaedic Surgery, University of California San Francisco, 505 Parnassus Ave MU 320W, San Francisco, CA, 94143, USA. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Spine Deform + 101603979 + 2212-134X + + IM + + Adolescent idiopathic scoliosis + Anterior vertebral body tethering + Patient-reported outcomes + Pediatric spine + +
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+ + + 36809652 + + 2023 + 02 + 22 + +
+ + 1530-6860 + + 37 + 3 + + 2023 + Mar + + + FASEB journal : official publication of the Federation of American Societies for Experimental Biology + FASEB J + + O-glycan structures in apo(a) subunit of human lipoprotein(a) suppresses the pro-angiogenic activity of galectin-1 on human umbilical vein endothelial cells. + + e22813 + + 10.1096/fj.202201001RR + + Apolipoprotein(a) [apo(a)] is a highly polymorphic O-glycoprotein circulating in human plasma as lipoprotein(a) [Lp(a)]. The O-glycan structures of apo(a) subunit of Lp(a) serve as strong ligands of galectin-1, an O-glycan binding pro-angiogenic lectin abundantly expressed in placental vascular tissues. But the pathophysiological significance of apo(a)-galectin-1 binding is not yet been revealed. Carbohydrate-dependent binding of galectin-1 to another O-glycoprotein, neuropilin-1 (NRP-1) on endothelial cells activates vascular endothelial growth factor receptor 2 (VEGFR2) and mitogen-activated protein kinase (MAPK) signaling. Using apo(a), isolated from human plasma, we demonstrated the potential of the O-glycan structures of apo(a) in Lp(a) to inhibit angiogenic properties such as proliferation, migration, and tube-formation in human umbilical vein endothelial cells (HUVECs) as well as neovascularization in chick chorioallantoic membrane. Further, in vitro protein-protein interaction studies have confirmed apo(a) as a superior ligand to NRP-1 for galectin-1 binding. We also demonstrated that the protein levels of galectin-1, NRP-1, VEGFR2, and downstream proteins in MAPK signaling were reduced in HUVECs in the presence of apo(a) with intact O-glycan structures compared to that of de-O-glycosylated apo(a). In conclusion, our study shows that apo(a)-linked O-glycans prevent the binding of galectin-1 to NRP-1 leading to the inhibition of galectin-1/neuropilin-1/VEGFR2/MAPK-mediated angiogenic signaling pathway in endothelial cells. As higher plasma Lp(a) level in women is an independent risk factor for pre-eclamsia, a pregnancy-associated vascular complication, we propose that apo(a) O-glycans-mediated inhibition of the pro-angiogenic activity of galectin-1 may be one of the underlying molecular mechanism of pathogenesis of Lp(a) in pre-eclampsia. + © 2023 Federation of American Societies for Experimental Biology. + + + + Kalaivani + Vasantha + V + https://orcid.org/0000-0002-5578-5744 + + Diabetes Biology Laboratory, Division of Cardiovascular Diseases and Diabetes Biology, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India. + + + + Krishna + Mahesh S + MS + + Diabetes Biology Laboratory, Division of Cardiovascular Diseases and Diabetes Biology, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India. + + + + Kumar + Asokan Aneesh + AA + + Diabetes Biology Laboratory, Division of Cardiovascular Diseases and Diabetes Biology, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India. + + + + Satheesh + Gopika + G + + Diabetes Biology Laboratory, Division of Cardiovascular Diseases and Diabetes Biology, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India. + + + + Jaleel + Abdul + A + + Diabetes Biology Laboratory, Division of Cardiovascular Diseases and Diabetes Biology, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India. + + + + eng + + + PDF/2016/002807 + DST | Science and Engineering Research Board (SERB) + + + + + Journal Article + +
+ + United States + FASEB J + 8804484 + 0892-6638 + + IM + + O-glycan + angiogenesis + apo(a) + galectin-1 + lipoprotein(a) + neuropilin-1 + +
+ + + + 2022 + 12 + 29 + + + 2022 + 06 + 24 + + + 2023 + 01 + 27 + + + 2023 + 2 + 22 + 13 + 59 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + ppublish + + 36809652 + 10.1096/fj.202201001RR + + + REFERENCES + + Lawn RM, Schwartz K, Patthy L. Convergent evolution of apolipoprotein(a) in primates and hedgehog. Proc Natl Acad Sci U S A. 1997;94:11992-11997. doi:10.1073/pnas.94.22.11992 + + + McLean JW, Tomlinson JE, Kuang WJ, et al. cDNA sequence of human apolipoprotein(a) is homologous to plasminogen. Nature. 1987;330:132-137. doi:10.1038/330132a0 + + + Garner B, Merry AH, Royle L, Harvey DJ, Rudd PM, Thillet J. Structural elucidation of the N- and O-glycans of human apolipoprotein(a): role of o-glycans in conferring protease resistance. J Biol Chem. 2001;276:22200-22208. doi:10.1074/jbc.M102150200 + + + Marcovina S, Zhang Z, Gaur V. Identification of 34 apolipoprotein(a) isoforms: differential expression of apolipoprotein (a) alleles between American blacks and whites. 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+ + + 36809646 + + 2023 + 02 + 22 + +
+ + 2299-5684 + + + 2023 + Feb + 21 + + + Pharmacological reports : PR + Pharmacol Rep + + Drug repositioning: diacerein as a new therapeutic approach in a mice model of sciatic nerve injury. + 10.1007/s43440-023-00461-9 + + Peripheral nerve injuries negatively impact the quality of life of patients, with no effective treatment available that accelerates sensorimotor recovery and promotes functional improvement and pain relief. The aim of this study was to evaluate the effects of diacerein (DIA) in an experimental mice model of sciatic nerve crush. + In this study, male Swiss mice were used, randomly separated into six groups as follows: FO (false-operated + vehicle); FO + DIA (false-operated + diacerein 30 mg/kg); SNI (sciatic nerve injury + vehicle); SNI + DIA in doses of 3, 10 and 30 mg/kg (sciatic nerve injury + treatment with diacerein in doses of 3-30 mg/kg). DIA or vehicle was administered 24 h after the surgical procedure, intragastrically, twice a day. The lesion of the right sciatic nerve was generated by crush. + We found that the treatment of animals with DIA accelerated sensorimotor recovery of the animal. In addition, animals in the sciatic nerve injury + vehicle (SNI) group showed hopelessness, anhedonia, and lack of well-being, which were significantly inhibited by DIA treatment. The SNI group showed a reduction in the diameters of nerve fibers, axons, and myelin sheaths, while DIA treatment recovered all these parameters. In addition, the treatment of animals with DIA prevented an increase the levels of interleukin (IL)-1β and a reduction in the levels of the brain-derived growth factor (BDNF). + Treatment with DIA reduces hypersensitivity and depression like behaviors in animals. Furthermore, DIA promotes functional recovery and regulates IL-1β and BDNF concentrations. + © 2023. The Author(s) under exclusive licence to Maj Institute of Pharmacology Polish Academy of Sciences. + + + + Karvat + Jhenifer + J + + Laboratory of Neurobiology of Pain and Inflammation (LANDI), Department of Physiological Sciences, Center of Biological Sciences, Federal University of Santa Catarina, University Campus, Trindade, Florianópolis, SC, 88040-900, Brazil. + + + Program of Post-Graduation in Neuroscience, Federal University of Santa Catarina, University Campus, Trindade, Florianópolis, SC, 88040-900, Brazil. + + + + Andrade + Tassiane Emanuelle Servare + TES + + Laboratory of Neurobiology of Pain and Inflammation (LANDI), Department of Physiological Sciences, Center of Biological Sciences, Federal University of Santa Catarina, University Campus, Trindade, Florianópolis, SC, 88040-900, Brazil. + + + Program of Post-Graduation in Neuroscience, Federal University of Santa Catarina, University Campus, Trindade, Florianópolis, SC, 88040-900, Brazil. + + + + Kraus + Scheila Iria + SI + + Laboratory of Neurobiology of Pain and Inflammation (LANDI), Department of Physiological Sciences, Center of Biological Sciences, Federal University of Santa Catarina, University Campus, Trindade, Florianópolis, SC, 88040-900, Brazil. + + + Program of Post-Graduation in Neuroscience, Federal University of Santa Catarina, University Campus, Trindade, Florianópolis, SC, 88040-900, Brazil. + + + + Beppler + Larissa May + LM + + Laboratory of Neurobiology of Pain and Inflammation (LANDI), Department of Physiological Sciences, Center of Biological Sciences, Federal University of Santa Catarina, University Campus, Trindade, Florianópolis, SC, 88040-900, Brazil. + + + + de Jesus + Gustavo Dos Santos Catarina + GDSC + + Laboratory of Neurobiology of Pain and Inflammation (LANDI), Department of Physiological Sciences, Center of Biological Sciences, Federal University of Santa Catarina, University Campus, Trindade, Florianópolis, SC, 88040-900, Brazil. + + + + Ferreira + Jeane Bachi + JB + + Laboratory of Neurobiology of Pain and Inflammation (LANDI), Department of Physiological Sciences, Center of Biological Sciences, Federal University of Santa Catarina, University Campus, Trindade, Florianópolis, SC, 88040-900, Brazil. + + + + da Silva + Morgana Duarte + MD + http://orcid.org/0000-0002-2487-236X + + Laboratory of Neurobiology of Pain and Inflammation (LANDI), Department of Physiological Sciences, Center of Biological Sciences, Federal University of Santa Catarina, University Campus, Trindade, Florianópolis, SC, 88040-900, Brazil. morgana.silva@ufsc.br. + + + Program of Post-Graduation in Neuroscience, Federal University of Santa Catarina, University Campus, Trindade, Florianópolis, SC, 88040-900, Brazil. morgana.silva@ufsc.br. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Switzerland + Pharmacol Rep + 101234999 + 1734-1140 + + IM + + Diacerein + Drug repositioning + Hypersensitivity + Peripheral nerve regeneration + +
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+ + + 36809645 + + 2023 + 02 + 22 + +
+ + 1469-493X + + 2 + + 2023 + Feb + 16 + + + The Cochrane database of systematic reviews + Cochrane Database Syst Rev + + Interventions for myopia control in children: a living systematic review and network meta-analysis. + + CD014758 + + 10.1002/14651858.CD014758.pub2 + + Myopia is a common refractive error, where elongation of the eyeball causes distant objects to appear blurred. The increasing prevalence of myopia is a growing global public health problem, in terms of rates of uncorrected refractive error and significantly, an increased risk of visual impairment due to myopia-related ocular morbidity. Since myopia is usually detected in children before 10 years of age and can progress rapidly, interventions to slow its progression need to be delivered in childhood. + To assess the comparative efficacy of optical, pharmacological and environmental interventions for slowing myopia progression in children using network meta-analysis (NMA). To generate a relative ranking of myopia control interventions according to their efficacy. To produce a brief economic commentary, summarising the economic evaluations assessing myopia control interventions in children. To maintain the currency of the evidence using a living systematic review approach.  SEARCH METHODS: We searched CENTRAL (which contains the Cochrane Eyes and Vision Trials Register), MEDLINE; Embase; and three trials registers. The search date was 26 February 2022.  SELECTION CRITERIA: We included randomised controlled trials (RCTs) of optical, pharmacological and environmental interventions for slowing myopia progression in children aged 18 years or younger. Critical outcomes were progression of myopia (defined as the difference in the change in spherical equivalent refraction (SER, dioptres (D)) and axial length (mm) in the intervention and control groups at one year or longer) and difference in the change in SER and axial length following cessation of treatment ('rebound').  DATA COLLECTION AND ANALYSIS: We followed standard Cochrane methods. We assessed bias using RoB 2 for parallel RCTs. We rated the certainty of evidence using the GRADE approach for the outcomes: change in SER and axial length at one and two years. Most comparisons were with inactive controls. + We included 64 studies that randomised 11,617 children, aged 4 to 18 years. Studies were mostly conducted in China or other Asian countries (39 studies, 60.9%) and North America (13 studies, 20.3%). Fifty-seven studies (89%) compared myopia control interventions (multifocal spectacles, peripheral plus spectacles (PPSL), undercorrected single vision spectacles (SVLs), multifocal soft contact lenses (MFSCL), orthokeratology, rigid gas-permeable contact lenses (RGP); or pharmacological interventions (including high- (HDA), moderate- (MDA) and low-dose (LDA) atropine, pirenzipine or 7-methylxanthine) against an inactive control. Study duration was 12 to 36 months. The overall certainty of the evidence ranged from very low to moderate. Since the networks in the NMA were poorly connected, most estimates versus control were as, or more, imprecise than the corresponding direct estimates. Consequently, we mostly report estimates based on direct (pairwise) comparisons below. At one year, in 38 studies (6525 participants analysed), the median change in SER for controls was -0.65 D. The following interventions may reduce SER progression compared to controls: HDA (mean difference (MD) 0.90 D, 95% confidence interval (CI) 0.62 to 1.18), MDA (MD 0.65 D, 95% CI 0.27 to 1.03), LDA (MD 0.38 D, 95% CI 0.10 to 0.66), pirenzipine (MD 0.32 D, 95% CI 0.15 to 0.49), MFSCL (MD 0.26 D, 95% CI 0.17 to 0.35), PPSLs (MD 0.51 D, 95% CI 0.19 to 0.82), and multifocal spectacles (MD 0.14 D, 95% CI 0.08 to 0.21). By contrast, there was little or no evidence that RGP (MD 0.02 D, 95% CI -0.05 to 0.10), 7-methylxanthine (MD 0.07 D, 95% CI -0.09 to 0.24) or undercorrected SVLs (MD -0.15 D, 95% CI -0.29 to 0.00) reduce progression.  At two years, in 26 studies (4949 participants), the median change in SER for controls was -1.02 D. The following interventions may reduce SER progression compared to controls: HDA (MD 1.26 D, 95% CI 1.17 to 1.36), MDA (MD 0.45 D, 95% CI 0.08 to 0.83), LDA (MD 0.24 D, 95% CI 0.17 to 0.31), pirenzipine (MD 0.41 D, 95% CI 0.13 to 0.69), MFSCL (MD 0.30 D, 95% CI 0.19 to 0.41), and multifocal spectacles  (MD 0.19 D, 95% CI 0.08 to 0.30). PPSLs (MD 0.34 D, 95% CI -0.08 to 0.76) may also reduce progression, but the results were inconsistent. For RGP, one study found a benefit and another found no difference with control. We found no difference in SER change for undercorrected SVLs (MD 0.02 D, 95% CI -0.05 to 0.09). At one year, in 36 studies (6263 participants), the median change in axial length for controls was 0.31 mm. The following interventions may reduce axial elongation compared to controls: HDA (MD -0.33 mm, 95% CI -0.35 to 0.30), MDA (MD -0.28 mm, 95% CI -0.38 to -0.17), LDA (MD -0.13 mm, 95% CI -0.21 to -0.05), orthokeratology (MD -0.19 mm, 95% CI -0.23 to -0.15), MFSCL (MD -0.11 mm, 95% CI -0.13 to -0.09), pirenzipine (MD -0.10 mm, 95% CI -0.18 to -0.02), PPSLs (MD -0.13 mm, 95% CI -0.24 to -0.03), and multifocal spectacles (MD -0.06 mm, 95% CI -0.09 to -0.04). We found little or no evidence that RGP (MD 0.02 mm, 95% CI -0.05 to 0.10), 7-methylxanthine (MD 0.03 mm, 95% CI -0.10 to 0.03) or undercorrected SVLs (MD 0.05 mm, 95% CI -0.01 to 0.11) reduce axial length. At two years, in 21 studies (4169 participants), the median change in axial length for controls was 0.56 mm. The following interventions may reduce axial elongation compared to controls: HDA (MD -0.47mm, 95% CI -0.61 to -0.34), MDA (MD -0.33 mm, 95% CI -0.46 to -0.20), orthokeratology (MD -0.28 mm, (95% CI -0.38 to -0.19), LDA (MD -0.16 mm, 95% CI -0.20 to  -0.12), MFSCL (MD -0.15 mm, 95% CI -0.19 to -0.12), and multifocal spectacles (MD -0.07 mm, 95% CI -0.12 to -0.03). PPSL may reduce progression (MD -0.20 mm, 95% CI -0.45 to 0.05) but results were inconsistent. We found little or no evidence that undercorrected SVLs (MD -0.01 mm, 95% CI -0.06 to 0.03) or RGP (MD 0.03 mm, 95% CI -0.05 to 0.12) reduce axial length. There was inconclusive evidence on whether treatment cessation increases myopia progression. Adverse events and treatment adherence were not consistently reported, and only one study reported quality of life. No studies reported environmental interventions reporting progression in children with myopia, and no economic evaluations assessed interventions for myopia control in children. + Studies mostly compared pharmacological and optical treatments to slow the progression of myopia with an inactive comparator. Effects at one year provided evidence that these interventions may slow refractive change and reduce axial elongation, although results were often heterogeneous. A smaller body of evidence is available at two or three years, and uncertainty remains about the sustained effect of these interventions. Longer-term and better-quality studies comparing myopia control interventions used alone or in combination are needed, and improved methods for monitoring and reporting adverse effects. + Copyright © 2023 The Authors. Cochrane Database of Systematic Reviews published by John Wiley & Sons, Ltd. on behalf of The Cochrane Collaboration. + + + + Lawrenson + John G + JG + + Centre for Applied Vision Research, School of Health & Psychological Sciences , City, University of London, London, UK. + + + + Shah + Rakhee + R + + Centre for Applied Vision Research, School of Health & Psychological Sciences , City, University of London, London, UK. + + + + Huntjens + Byki + B + + Centre for Applied Vision Research, School of Health & Psychological Sciences , City, University of London, London, UK. + + + + Downie + Laura E + LE + + Department of Optometry and Vision Sciences, The University of Melbourne, Melbourne, Australia. + + + + Virgili + Gianni + G + + Department of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Florence, Italy. + + + Centre for Public Health, Queen's University Belfast, Belfast, UK. + + + + Dhakal + Rohit + R + + Myopia Research Lab, Prof. Brien Holden Eye Research Centre, L V Prasad Eye Institute, Hyderabad, India. + + + + Verkicharla + Pavan K + PK + + Myopia Research Lab, Prof. Brien Holden Eye Research Centre, L V Prasad Eye Institute, Hyderabad, India. + + + + Li + Dongfeng + D + + Centre for Public Health, Queen's University Belfast, Belfast, UK. + + + Department of Ophthalmology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China. + + + + Mavi + Sonia + S + + Centre for Public Health, Queen's University Belfast, Belfast, UK. + + + + Kernohan + Ashleigh + A + + Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK. + + + + Li + Tianjing + T + + Department of Ophthalmology, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, USA. + + + + Walline + Jeffrey J + JJ + + College of Optometry, The Ohio State University, Columbus, Ohio, USA. + + + + eng + + + ClinicalTrials.gov + + NCT00371124 + NCT00977236 + NCT00787579 + NCT01829191 + NCT01829230 + NCT00009529 + NCT00320593 + NCT00000113 + NCT00214487 + NCT00919334 + NCT00000128 + NCT00962208 + NCT00335049 + NCT00263471 + NCT00522288 + NCT00000123 + NCT01236742 + NCT00657670 + ACTRN12611000582954 + NCT01917110 + + + + + Journal Article + Review + + + 2023 + 02 + 16 + +
+ + England + Cochrane Database Syst Rev + 100909747 + 1361-6137 + + IM + + La miopía es un defecto de refracción frecuente, en el que el alargamiento del globo ocular hace que los objetos lejanos aparezcan borrosos. La creciente prevalencia de la miopía es un problema de salud pública mundial cada vez mayor, en cuanto a tasas de defectos de refracción no corregidos y un significativamente mayor riesgo de discapacidad visual debido a la morbilidad ocular relacionada con la miopía. Dado que la miopía se suele detectar en niños antes de los 10 años y puede evolucionar rápidamente, las intervenciones para frenar su avance se deben realizar en la infancia. + Evaluar la eficacia comparativa de las intervenciones ópticas, farmacológicas y ambientales para frenar la progresión de la miopía en niños mediante un metanálisis en red (MAR). Generar una clasificación relativa de las intervenciones de control de la miopía en función de su eficacia. Elaborar un breve comentario económico que resuma las evaluaciones económicas de las intervenciones de control de la miopía en niños. Mantener la vigencia de la evidencia mediante un enfoque de revisión sistemática continua. MÉTODOS DE BÚSQUEDA: Se realizaron búsquedas en CENTRAL (que contiene el Registro de ensayos del Grupo Cochrane de Salud ocular y de la visión [Cochrane Eyes and Vision]), MEDLINE; Embase; y en tres registros de ensayos. La fecha de búsqueda fue el 26 de febrero de 2022. CRITERIOS DE SELECCIÓN: Se incluyeron ensayos controlados aleatorizados (ECA) de intervenciones ópticas, farmacológicas y ambientales para retrasar la progresión de la miopía en niños de hasta 18 años. Los desenlaces fundamentales fueron la progresión de la miopía (definida como la diferencia en el cambio del equivalente esférico de la refracción [EER, dioptrías (D)] y la longitud axial [mm] en los grupos de intervención y control al año o más) y la diferencia en el cambio del EER y la longitud axial tras el cese del tratamiento ("rebote"). OBTENCIÓN Y ANÁLISIS DE LOS DATOS: Se utilizaron los métodos Cochrane estándar. El sesgo se evaluó mediante la herramienta RoB 2 en el caso de los ECA paralelos. La certeza de la evidencia se calificó mediante el método GRADE para los desenlaces: cambio del EER y la longitud axial al año y a los dos años. La mayoría de las comparaciones se realizaron con controles inactivos. + Se incluyeron 64 estudios que asignaron al azar a 11 617 niños de cuatro a 18 años de edad. Los estudios se realizaron principalmente en China u otros países asiáticos (39 estudios; 60,9%) y Norteamérica (13 estudios; 20,3%). Cincuenta y siete estudios (89%) compararon intervenciones de control de la miopía (gafas multifocales, gafas periféricas plus [PPSL por sus siglas en inglés], gafas monofocales [SVL por sus siglas en inglés] subcorregidas, lentes de contacto multifocales blandas [MFSCL por sus siglas en inglés], ortoqueratología, lentes de contacto rígidas permeables al gas [RGP por sus siglas en inglés]); o intervenciones farmacológicas (incluidas atropina a dosis alta, media y baja, pirenzipina o 7‐metilxantina) contra un control inactivo. La duración de los estudios fue de 12 a 36 meses. La certeza global de la evidencia varió entre muy baja y moderada. Debido a que las redes del MAR estaban mal conectadas, la mayoría de las estimaciones versus control fueron tan imprecisas o más que las correspondientes estimaciones directas. En consecuencia, a continuación se presentan principalmente estimaciones basadas en comparaciones directas (por pares). Al año, en 38 estudios (6525 participantes analizados), la mediana del cambio del EER para los controles fue de ‐0,65 D. Las siguientes intervenciones podrían reducir la progresión del EER en comparación con los controles: atropina a dosis alta (diferencia de medias [DM] 0,90 D; intervalo de confianza [IC] del 95%: 0,62 a 1,18), atropina a dosis media (DM 0,65 D; IC del 95%: 0,27 a 1,03), atropina a dosis baja (DM 0,38 D; IC del 95%: 0,10 a 0,66), pirenzipina (DM 0,32 D; IC del 95%: 0,15 a 0,49), MFSCL (DM 0,26 D; IC del 95%: 0,17 a 0,35), PPSL (DM 0,51 D; IC del 95%: 0,19 a 0,82) y gafas multifocales (DM 0,14 D; IC del 95%: 0,08 a 0,21). Por el contrario, hubo poca o ninguna evidencia de que las RGP (DM 0,02 D; IC del 95%: ‐0,05 a 0,10), la 7‐metilxantina (DM 0,07 D; IC del 95%: ‐0,09 a 0,24) o las SVL subcorregidas (DM ‐0,15 D; IC del 95%: ‐0,29 a 0,00) redujeran la progresión. A los dos años, en 26 estudios (4949 participantes), el cambio medio del EER para los controles fue de ‐1,02 D. Las siguientes intervenciones podrían reducir la progresión del EER en comparación con los controles: atropina a dosis alta (DM 1,26 D; IC del 95%: 1,17 a 1,36), atropina a dosis media (DM 0,45 D; IC del 95%: 0,08 a 0,83), atropina a dosis baja (DM 0,24 D; IC del 95%: 0,17 a 0,31), pirenzipina (DM 0,41 D; IC del 95%: 0,13 a 0,69), MFSCL (DM 0,30 D; IC del 95%: 0,19 a 0,41) y gafas multifocales (DM 0,19 D; IC del 95%: 0,08 a 0,30). Las PPSL (DM 0,34 D; IC del 95%: ‐0,08 a 0,76) también podrían reducir la progresión, pero los resultados no fueron consistentes. Para las RGP, un estudio encontró un efecto beneficioso y otro no encontró diferencias con el control. No se observaron diferencias en el cambio del EER para las SVL subcorregidas (DM 0,02 D; IC del 95%: ‐0,05 a 0,09). Al año, en 36 estudios (6.263 participantes), el cambio medio en la longitud axial de los controles fue de 0,31 mm. Las siguientes intervenciones podrían reducir la elongación axial en comparación con los controles: atropina a dosis alta (DM ‐0,33 mm; IC 95%: ‐0,35 a 0,30), atropina a dosis media (DM ‐0,28 mm; IC 95%: ‐0,38 a ‐0,17), atropina a dosis baja (DM ‐0,13 mm; IC 95%: ‐0,21 a ‐0,05), ortoqueratología (DM ‐0,19 mm; IC 95%: ‐0,23 a ‐0,15), MFSCL (DM ‐0,11 mm; IC del 95%: ‐0,13 a ‐0,09), pirenzipina (DM ‐0,10 mm; IC del 95%: ‐0,18 a ‐0,02), PPSL (DM ‐0,13 mm; IC del 95%: ‐0,24 a ‐0,03) y gafas multifocales (DM ‐0,06 mm; IC del 95%: ‐0,09 a ‐0,04). Se encontró poca o ninguna evidencia de que las RGP (DM 0,02 mm; IC del 95%: ‐0,05 a 0,10), la 7‐metilxantina (DM 0,03 mm; IC del 95%: ‐0,10 a 0,03) o las SVL subcorregidas (DM 0,05 mm; IC del 95%: ‐0,01 a 0,11) reduzcan la longitud axial. A los dos años, en 21 estudios (4169 participantes), la mediana del cambio en la longitud axial de los controles fue de 0,56 mm. Las siguientes intervenciones podrían reducir la elongación axial en comparación con los controles: atropina a dosis alta (DM ‐0,47 mm; IC del 95%: ‐0,61 a ‐0,34), atropina a dosis media (DM ‐0,33 mm; IC del 95%: ‐0,46 a ‐0,20), ortoqueratología (DM ‐0,28 mm; IC del 95%: ‐0,38 a ‐0,19), atropina a dosis baja (DM ‐0,16 mm; IC del 95%: ‐0,20 a ‐0,12), MFSCL (DM ‐0,15 mm; IC del 95%: ‐0,19 a ‐0,12) y gafas multifocales (DM ‐0,07 mm; IC del 95%: ‐0,12 a ‐0,03). Las PPSL podrían reducir la progresión (DM ‐0,20 mm; IC del 95%: ‐0,45 a 0,05), pero los resultados no fueron consistentes. Se encontró poca o ninguna evidencia de que las SVL subcorregidas (DM ‐0,01 mm; IC del 95%: ‐0,06 a 0,03) o las RGP (DM 0,03 mm; IC del 95%: ‐0,05 a 0,12) reduzcan la longitud axial. No hubo evidencia concluyente sobre si el abandono del tratamiento aumenta la progresión de la miopía. Los eventos adversos y la adherencia al tratamiento no se comunicaron de forma consistente, y solo un estudio informó sobre la calidad de vida. Ningún estudio proporcionó información sobre intervenciones ambientales que informaran sobre la progresión en niños con miopía y ninguna evaluación económica analizó intervenciones para el control de la miopía en niños. + La mayoría de los estudios compararon tratamientos farmacológicos y ópticos para enlentecer la progresión de la miopía con un comparador inactivo. Los efectos al año demostraron que estas intervenciones podrían ralentizar el cambio refractivo y reducir el alargamiento axial, aunque a menudo los resultados fueron heterogéneos. El conjunto de evidencia disponible a los dos o tres años fue más escaso, y persiste la incertidumbre sobre el efecto sostenido de estas intervenciones. Se necesitan estudios a más largo plazo y de mejor calidad que comparen las intervenciones para el control de la miopía utilizadas solas o en combinación, así como métodos mejorados de seguimiento y notificación de los efectos adversos. + +
+ + + + 2023 + 2 + 22 + 13 + 58 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + epublish + + 36809645 + 10.1002/14651858.CD014758.pub2 + + + References + + References to studies included in this review + + Adler 2006 {published data only} + + Adler D, Millodot M. The possible effect of undercorrection on myopic progression in children. Clinical and Experimental Optometry 2006;89(5):315-21. + + + + Anstice 2011 {published data only} + + Anstice NS, Phillips JR. Effect of dual-focus soft contact lens wear on axial myopia progression in children. Ophthalmology 2011;118(6):1152-61. + + + + ATOM 2 Study 2012 {published data only}NCT00371124 + + Chia A, Chua WH, Cheung YB, Wong WL, Lingham A, Fong A, et al. Atropine for the treatment of childhood myopia: safety and efficacy of 0.5%, 0.1%, and 0.01% doses (Atropine for the treatment of myopia 2). Ophthalmology 2012;119(2):347-54. + + + Chia A, Chua WH, Wen L, Fong A, Goon YY, Tan D. 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Effect of topical atropine on astigmatism. British Journal of Ophthalmology 2009;93(6):799-802. + + + Chua W, Balakrishnan V, Chan Y. Analysis of safety data for atropine in the treatment of myopia (ATOM) study. Investigative Ophthalmology and Visual Science 2002;43(13):ARVO E-abstract 329. + + + Chua W, Balakrishnan V, Tan D, Chan Y. Efficacy results from the atropine in the treatment of myopia (ATOM) study. Investigative Ophthalmology and Visual Science 2003;44(13):ARVO E-abstract 3119. + + + Chua WH, Balakrishnan V, Chan YH, Tong L, Ling Y, Quah BL, et al. Atropine for the treatment of childhood myopia. Ophthalmology 2006;113(12):2285-91. + + + Chua WH, Tan D, Balakrishnan V, Chan YH, ATOM Study Group. Progression of childhood myopia following cessation of atropine treatment. Investigative Ophthalmology and Visual Science 2005;46(13):ARVO E-abstract 4625. + + + Kumaran A, Htoon HM, Tan D, Chia A. Analysis of changes in refraction and biometry of atropine- and placebo-treated eyes. Investigative Ophthalmology and Visual Science 2015;56(9):5650-5. + + + Loh KL, Lu Q, Tan D, Chia A. Risk factors for progressive myopia in the atropine therapy for myopia study. American Journal of Ophthalmology 2015;159(5):945-9. + + + Luu CD, Lau AM, Koh AH, Chua WH, Balakrishnan V, Tan D. Effects of long-term atropine usage on retinal function. Investigative Ophthalmology and Visual Science 2003;44(13):ARVO E-abstract 4790. + + + Luu CD, Lau AM, Koh AH, Tan D. Multifocal electroretinogram in children on atropine treatment for myopia. British Journal of Ophthalmology 2005;89(2):151-3. + + + Tong L, Huang XL, Koh AL, Zhang X, Tan DT, Chua WH. Atropine for the treatment of childhood myopia: effect on myopia progression after cessation of atropine. Ophthalmology 2009;116(3):572-9. + + + + Bao 2021 {published data only} + + Bao J, Huang Y, Li X, Pan Y, Ding C, Lim EW, et al. Myopia control with spectacle lenses with aspherical lenslets: a 2-year randomized clinical trial. British Journal of Ophthalmology 2022;106(8):1171-6. + + + Bao J, Yang A, Huang Y, Li X, Yang A, Lim W, et al. One-year myopia control efficacy of spectacle lenses with aspherical lenslets. Investigative Ophthalmology and Visual Science 2021;62(8):2888. + + + + Bian 2020 {published data only} + + Bian S, Liu H, Lin J. A randomized-controlled clinical study of one-year outcome between orthokeratology contact lens wear and glasses wear in myopic children. Chinese Journal of Experimental Ophthalmology 2020;38(2):121-7. + + + + BLINK Study 2020 {published data only} + + Berntsen DA, Gostovic AT, Sinnott LT, Chandler MA, Huang J, Morrison A, et al. Peripheral defocus and axial eye growth in the bifocal lenses in nearsighted kids (BLINK) study. Investigative Ophthalmology and Visual Science 2021;62(8):ARVO E-abstract 2884. + + + Walline JJ, Walker MK, Mutti DO, Jones-Jordan LA, Sinnott LT, Giannoni AG, et al. Effect of high add power, medium add power, or single-vision contact lenses on myopia progression in children: the BLINK randomized clinical trial. JAMA 2020;324(6):571-80. + + + + Chamberlain 2019 {published data only} + + Chamberlain P, Arumugam B Jones D, Logan N, Peixoto-de-Matos S, Young G. Further comparison of myopia progression in new and established myopia control treatment (MiSight) groups. Contact Lens and Anterior Eye 2019;42(6 Suppl):e16. + + + Chamberlain P, Bradley A, Arumugam B, Hammond, D, McNally J, Logan NS, et al. Long-term effect of dual-focus conact lenses on myopia progression in children: a 6-year multicentre clinical trial. Optometry and Vision Science 2022;99(3):204-12. + + + Chamberlain P, Hammond D, Arumugam B, Bullimore MA. Measured and predicted axial elongation in the MiSight 1 day clinical trial – 6 year results. Investigative Ophthalmology & Visual Science 2021;62(8):2342. + + + Chamberlain P, Peixoto-de-Matos SC, Logan NS, Ngo C, Jones D, Young G. 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Longitudinal measures of intraocular pressure and axial length in a subgroup of children in the Correction of Myopia Evaluation Trial (COMET). Investigative Ophthalmology and Visual Science 2007;48(13):ARVO E-abstract 4829. + + + Dias L, Hyman L, Manny RE, Fern K, COMET Group. Evaluating the self-esteem of myopic children over a three-year period: the COMET experience. Optometry and Vision Science 2005;82(4):338-47. + + + Dias L, Manny R, Hyman L, Fern K, COMET Group. Ocular factors and self perception in myopic children. Investigative Ophthalmology and Visual Science 2001;42(13):ARVO E-abstract 2101. + + + Dias L, Manny RE, Hyman L, Fern K. The relationship between self-esteem of myopic children and ocular and demographic characteristics. Optometry and Vision Science 2002;79(11):688-96. + + + Dias L, Manny RE, Weissberg E, Fern KD. Myopia, contact lens use and self-esteem. 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Optometry and Vision Science 2006;83(1):46-52. + + + Fern KD, Manny RE, Gwiazda J, Hyman L, Weise K, Marsh-Tootle W, et al. Intraocular pressure and central corneal thickness in the COMET cohort. Optometry and Vision Science 2012;89(8):1225-34. + + + Gwiazda J, Deng L, Dias L, Marsh-Tootle W, COMET Study Group. Association of education and occupation with myopia in COMET parents. Optometry and Vision Science 2011;88(9):1045-53. + + + Gwiazda J, Deng L, Manny R, Norton TT, COMET Study Group. Seasonal variations in the progression of myopia in children enrolled in the Correction of Myopia Evaluation Trial. Investigative Ophthalmology & Visual Science 2014;55(2):752-8. + + + Gwiazda J, Hyman L, Dong LM, Everett D, Norton T, COMET Group. Factors associated with high myopia after 7 years of follow-up in the Correction of Myopia Evaluation Trial (COMET) cohort. Ophthalmic Epidemiology 2007;14(4):230-7. + + + Gwiazda J, Hyman L, Hussein M, Everett D, Norton TT, Kurtz D, et al. A randomized clinical trial of progressive addition lenses versus single vision lenses on the progression of myopia in children. Investigative Ophthalmology and Visual Science 2003;44(4):1492-500. + + + Gwiazda J, Marsh-Tootle WL, Hyman L, Hussein M, Norton TT, COMET Group. Baseline refractive and ocular component measures of children enrolled in the Correction of Myopia Evaluation Trial (COMET). Investigative Ophthalmology and Visual Science 2002;43(2):314-21. + + + Gwiazda J, Norton TT, Hou W, Hyman L, Manny R, COMET Group. Longitudinal changes in lens thickness in myopic children enrolled in the Correction of Myopia Evaluation Trial (COMET). Current Eye Research 2016;41(4):492-500. + + + Gwiazda JE, Hyman L, Everett D, Norton T, Kurtz D, Manny R, et al. Five-year results from the Correction of Myopia Evaluation Trial (COMET). Investigative Ophthalmology and Visual Science 2006;47(13):ARVO E-abstract 1166. + + + Gwiazda JE, Hyman L, Norton T, Hussein M, Marsh-Tootle W, COMET Group. Baseline accommodation and related risk factors associated with myopia progression and their interaction with treatment in COMET children. Investigative Ophthalmology and Visual Science 2004;45(13):ARVO E-abstract 2740. + + + Gwiazda JE, Hyman L, Norton TT, Hussein ME, Marsh-Tootle W, COMET Group. Accommodation and related risk factors associated with myopia progression and their interaction with treatment in COMET children. Investigative Ophthalmology and Visual Science 2004;45(7):2143-51. + + + Harb E, Hyman L, Fazzari M, Gwiazda J, Marsh-Tootle W. Factors associated with macular thickness in the COMET myopic cohort. Optometry and Vision Science 2012;89(5):620-31. + + + Harb E, Hyman L, Gwiazda J, Marsh-Tootle W, Zhang Q, Hou W, et al. Choroidal thickness profiles in myopic eyes of young adults in the Correction of Myopia Evaluation Trial cohort. American Journal of Ophthalmology 2015;160(1):62-71. + + + Hardy R, Hillis A, Mutti D, Stone R, Taylor C Sr, Hyman L, et al. Myopia stabilization and associated factors among participants in the Correction of Myopia Evaluation Trial (COMET). Investigative Ophthalmology and Visual Science 2013;54(13):7871-83. + + + Hussein M, Gwiazda J, Hyman L. Reliability of measurements of phoria and accommodation in the Correction of Myopia Evaluation Trial (COMET). Investigative Ophthalmology & Visual Science 2001;42(13):ARVO E-abstract 2110. + + + Hyman L, Gwiazda J, Hussein M, Norton TT, Wang Y, Marsh-Tootle W, et al. Relationship of age, sex, and ethnicity with myopia progression and axial elongation in the Correction of Myopia Evaluation Trial. Archives of Ophthalmology 2005;123(7):977-87. + + + Hyman L, Gwiazda J, Hussein M, Norton TT, Wang Y, Marsh-Tootle W, et al. Relationship of baseline age, gender and ethnicity with 3-year myopia progression and axial elongation in the Correction of Myopia Evaluation Trial (COMET). Investigative Ophthalmology and Visual Science 2004;45(13):ARVO E-abstract 2734. + + + Hyman L, Gwiazda J, Marsh-Tootle WL, Norton TT, Hussein M, COMET Group. The Correction of Myopia Evaluation Trial (COMET): design and general baseline characteristics. Controlled Clinical Trials 2001;22(5):573-92. + + + Hyman L, Gwiazda J, Marsh-Tootle WL, Norton TT, COMET Group. The Correction of Myopia Evaluation Trial (COMET): design and baseline characteristics. In: Investigative Ophthalmology and Visual Science. Vol. 40. 1999:S754. + + + Hyman L, Gwiazda J. The Correction of Myopia Evaluation Trial: lessons from the study design. Annals of the Academy of Medicine Singapore 2004;33(1):44-8. + + + Hyman L, Hussein M, Gwiazda J, COMET Group. Validity of cycloplegic autorefraction and axial length measurements in a clinical trial. Investigative Ophthalmology and Visual Science 1998;39:S4348. + + + Kowalski PM, Wang Y, Owens RE, Bolden J, Smith JB, Hyman L. Adaptability of myopic children to progressive addition lenses with a modified fitting protocol in the Correction of Myopia Evaluation trial (COMET). Optometry and Vision Science 2005;82(4):328-37. + + + Kurtz D, Hyman L, Gwiazda JE, Manny R, Dong LM, COMET Group. Role of parental myopia in the progression of myopia and its interaction with treatment in COMET children. Investigative Ophthalmology and Visual Science 2007;48(2):562-70. + + + Kurtz D, Manny R, Hussein M, COMET Group. Reliability of ocular components measured by A-scan in children. In: Optometry and Vision Science. Vol. 77. 2000:S286. + + + Kurtz D, Manny R, Hussein M. Variability of the ocular component measurements in children using A-scan ultrasonography. Optometry and Vision Science 2004;81(1):35-43. + + + Manny RE, Deng L, Crossnoe C, Gwiazda J. Intraocular pressure (IOP) and myopic progression in a subgroup of COMET (Correction of Myopia Evaluation Trial) children. In: American Academy of Optometry. 2006. + + + Manny RE, Deng L, Crossnoe C, Gwiazda J. IOP, myopic progression and axial length in a COMET subgroup. Optometry and Vision Science 2008;85(2):97-105. + + + Manny RE, Hussein M, Gwiazda J, Marsh-Tootle W, COMET Group. Repeatability of ETDRS visual acuity in children. Investigative Ophthalmology and Visual Science 2003;44(8):3294-300. + + + Manny RE, Hussein M, Marsh-Tootle Wl, Gwiazda J. Reliability of ETDRS visual acuity (VA) in the Correction of Myopia Evaluation Trial (COMET). In: American Academy of Optometry. 2000:279. + + + Manny RE, Hussein M, Scheiman M, Kurtz D, Niemann K, COMET Group. Tropicamide (1%): an effective cycloplegic agent for myopic children. Investigative Ophthalmology and Visual Science 2001;42(8):1728-35. + + + Manny RE, Hussein ME, Grice K, Scheiman M, Kurtz D, Niemann K, et al. Tropicamide 1% as a cycloplegic agent in the Correction of Myopia Evaluation Trial (COMET). In: Investigative Ophthalmology and Visual Science. Vol. 40. 1999:S3673. + + + Marsh-Tootle WL, Gwiazda J, Hyman L, Norton TT. Refractive, phoria, and axial measures at baseline in children enrolled in the Correction of Myopia Evaluation Trial (COMET). Investigative Ophthalmology and Visual Science 1999;40:S3992. + + + Marsh-Tootle WL, Hyman L, Dong LM, Gwiazda J, Zhang Q. Myopia progression in adolescents in the Correction of Myopia Evaluation Rrial (COMET) who switched to contact lenses versus remained in spectacles. In: American Academy of Optometry. 2007. + + + Marsh-Tootle WL, Li MD, Weise KK, Fern KD, Gwiazda J, Norton T, et al. Myopia progression in children wearing spectacles vs. switching to contact lenses. Optometry and Vision Science 2009;86(6):741-7. + + + Norton TT, Hyman L, Dong L, Gwiazda J. Longitudinal changes in lens thickness in myopic children enrolled in the Correction of Myopia Evaluation Trial (COMET). Investigative Ophthalmology and Visual Science 2008;49:ARVO E-abstract 2603. + + + Scheiman M, Gwiazda J, Zhang Q, Deng L, Fern K, Manny RE, et al. Longitudinal changes in corneal curvature and its relationship to axial length in the Correction of Myopia Evaluation Trial (COMET) cohort. Journal of Optometry 2016;9(1):13-21. + + + Scheiman M, Zhang Q, Gwiazda J, Hyman L, Harb E, Weissberg E, et al. Visual activity and its association with myopia stabilisation. Ophthalmic and Physiological Optics 2014;34(3):353-61. + + + + CONTROL Study 2016 {published data only}NCT00214487 + + Aller TA, Liu M, Wildsoet CF. Myopia control with bifocal contact lenses: a randomized clinical trial. Optometry and Vision Science 2016;93(4):344-52. + + + Aller TA, Wildsoet C. Results of a one-year prospective clinical trial (CONTROL) of the use of bifocal soft contact lenses to control myopia progression. Ophthalmic and Physiological Optics 2006;26 Suppl 1:8-9. + + + Aller TA. Design of a prospective clinical trial of the use of bifocal soft contact lenses to control myopia progression (CONTROL). In: 10th International Myopia Conference. 2004. + + + + Cui 2021 {published data only} + + Cui C, Li X, Lyu Y, Wei L, Zhao B, Yu S, et al. Safety and efficacy of 0.02% and 0.01% atropine on controlling myopia progression: a 2-year clinical trial. Scientific Reports 2021;11(1):22267. + + + Fu A, Stapleton F, Wei L, Wang W, Zhao B, Watt K, et al. Risk factors for rapid axial length elongation with low concentration atropine for myopia control. Scientific Reports 2021;11(1):11729. + + + Qin J, Lyu Y, Wei L, Zhang J, Zhao B, Fu A. Comparison of myopia progression between different concentrations and application frequencies of atropine eye drops in children. Chinese Journal of Experimental Ophthalmology 2021;39(5):423-9. + + + + DISC Study 2011 {published data only}NCT00919334 + + Lam CS, Tang WC, Tang YY. Randomised clinical trial of myopia control in myopic schoolchildren using the defocus incorporated soft contact (DISC) lens. Optometry and Vision Science 2011;88(3):444-5. + + + Lam CS, Tang WC, Tse DY, Tang YY, To CH. Defocus incorporated soft contact (DISC) lens slows myopia progression in Hong Kong Chinese schoolchildren: a 2-year randomised clinical trial. British Journal of Ophthalmology 2014;98(1):40-5. + + + + Edwards 2002 {published data only} + + Edwards MH, Li RW, Lam CS, Lew JK, Yu BS. The Hong Kong progressive lens myopia control study: study design and main findings. Investigative Ophthalmology and Visual Science 2002;43(9):2852-8. + + + + Fujikado 2014 {published data only} + + Fujikado T, Ninomiya S, Kobayashi T, Suzaki A, Nakada M, Nishida K. Effect of low-addition soft contact lenses with decentered optical design on myopia progression in children: a pilot study. Clinical Ophthalmology 2014;8:1947-56. + + + + Fulk 1996 {published data only} + + Fulk GW, Cyert LA. Can bifocals slow myopia progression? Journal of the American Optometric Association 1996;67(12):749-54. + + + + Fulk 2002 {published data only}NCT00000128 + + Fulk GW, Cyert LA, Parker DE, West RW. The effect of changing from glasses to soft contact lenses on myopia progression in adolescents. Ophthalmic and Physiological Optics 2003;23(1):71-7. + + + Fulk GW, Cyert LA, Parker DE. A 3-year clinical trial of bifocals in children with near point esophoria: myopia progression during the first year. Investigative Ophthalmology and Visual Science 1998;39:S2982. + + + Fulk GW, Cyert LA, Parker DE. A 3-year clinical trial of bifocals to slow myopia progression in children with near-point esophoria: baseline characteristics. Investigative Ophthalmology and Visual Science 1997;38:S5404. + + + Fulk GW, Cyert LA, Parker DE. A clinical trial of bifocals in children: myopia progression after two years. 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Optometry and Vision Science 2002;79(1):46-51. + + + + Garcia‐del Valle 2021 {published data only} + + Garcia-Del Valle AM, Blázquez V, Gros-Otero J, Infante M, Culebras A, Verdejo A, et al. Efficacy and safety of a soft contact lens to control myopia progression. Clinical and Experimental Optometry 2021;104(1):14-21. + + + + Guo 2021 {published data only} + + Guo B, Cheung SW, Kojima R, Cho P. One-year results of the Variation of Orthokeratology Lens Treatment Zone (VOLTZ) study: a prospective randomised clinical trial. Ophthalmic and Physiological Optics 2021;41(4):702-14. + + + + Han 2018 {published data only} + + Han X, Xu D, Ge W, Wang Z, Li X, Liu W. A comparison of the effects of orthokeratology lens, Medcall lens, and ordinary frame glasses on the accommodative response in myopic children. Eye and Contact Lens 2018;44(4):268-71. + + + + Han 2019 {published data only} + + Han WT, Rong A, Xu W. Combination with different anticholinergic eyedrops for the treatment of children myopia. National Medical Journal of China 2019;99(24):1859-63. + + + + Hasebe 2008 {published data only}28611140 + + Fujiwara M, Hasebe S, Nakanishi R, Tanigawa K, Ohtsuki H. Seasonal variation in myopia progression and axial elongation: an evaluation of Japanese children participating in a myopia control trial. Japanese Journal of Ophthalmology 2012;56(4):401-6. + + + Hasebe S, Nakatsuka C, Hamasaki I, Ohtsuki H. Downward deviation of progressive addition lenses in a myopia control trial. Ophthalmic and Physiological Optics 2005;25(4):310-4. + + + Hasebe S, Nonaka F, Nakatsuka C, Ohtsuki H. Myopia control trial with progressive addition lenses in Japanese schoolchildren: baseline measures of refraction, accommodation, and heterophoria. Japanese Journal of Ophthalmology 2005;49(1):23-30. + + + Hasebe S, Ohtsuki H, Nonaka T, Nakatsuka C, Miyata M, Hamasaki I, et al. Effect of progressive addition lenses on myopia progression in Japanese children: a prospective, randomized, double-masked, crossover trial. Investigative Ophthalmology and Visual Science 2008;49(7):2781-9. + + + Hasebe S. A clinical trial to evaluate progressive addition lenses on myopia control. Study design. Japanese Journal of Vision Science 2002;23:63-8. + + + Nakatsuka C, Hasebe S, Nonaka F, Ohtsuki H. Assessment of downward deviation of progressive addition lenses in a myopia control study. Investigative Ophthalmology and Visual Science 2004;45(13):ARVO E-abstract 2732. + + + Suemaru J, Hasebe S, Ohtsuki H. Visual symptoms and compliance with spectacle wear in myopic children: double-masked comparison between progressive addition lenses and single vision lenses. Acta Medica Okayama 2008;62(2):109-17. + + + + Hasebe 2014 {published data only} + + Hasebe S, Jun J, Varnas SR. Myopia control with positively aspherized progressive addition lenses: a 2-year, multicenter, randomized, controlled trial. Investigative Ophthalmology and Visual Science 2014;55(11):7177-88. + + + + Hieda 2021 {published data only} + + Hieda O, Hiraoka T, Fujikado T, Ishiko S, Hasebe S, Torii H, et al. Efficacy and safety of 0.01% atropine for prevention of childhood myopia in a 2-year randomized placebo-controlled study. Japanese Journal of Ophthalmology 2021;65(3):315-25. + + + + Houston Study 1987 {published data only} + + Grosvenor T, Maslovitz B, Perrigin DM, Perrigin J. The Houston Myopia Control Study: a preliminary report by the patient care team. Journal of the American Optometric Association 1985;56(8):636-43. + + + Grosvenor T, Perrigin DM, Perrigin J, Maslovitz B. Houston Myopia Control Study: a randomized clinical trial. Part II. Final report by the patient care team. American Journal of Optometry and Physiological Optics 1987;64(7):482-98. + + + Young FA, Leary GA, Grosvenor T, Maslovitz B, Perrigin DM, Perrigin J, et al. Houston Myopia Control Study: a randomized clinical trial. Part I. Background and design of the study. American Journal of Optometry and Physiological Optics 1985;62(9):605-13. + + + + Jakobsen 2022 {published data only} + + Jakobsen TM, Moller F. Control of myopia using orthokeratology lenses in Scandinavian children aged 6 to 12 years. Eighteen-month data from the Danish randomized study: Clinical Study of Near-sightedness; Treatment with Orthokeratology Lenses (CONTROL study). Acta Ophthalmologica 2022;100(2):175-82. + + + + Jensen 1991 {published data only} + + Jensen H. Myopia progression in young school children. A prospective study of myopia progression and the effect of a trial with bifocal lenses and beta blocker eye drops. Acta Ophthalmologica 1991;200(Suppl):1-79. + + + Jensen H. 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Relationship between reduced accommodative lag and myopia progression. Optometry and Vision Science 2016;93(7):683-91. + + + + Lam 2020 {published data only} + + Lam CS, Tang WC, Lee PH, Zhang HY, Qi H, Hasegawa K, et al. Myopia control effect of defocus incorporated multiple segments (DIMS) spectacle lens in Chinese children: results of a 3-year follow-up study. British Journal of Ophthalmology 2021;106(8):1110-4. + + + Lam CS, Tang WC, Tse DY, Lee RP, Chun RK, Hasegawa K, et al. Defocus incorporated multiple segments (DIMS) spectacle lenses slow myopia progression: a 2-year randomised clinical trial. British Journal of Ophthalmology 2020;104(3):363-8. + + + + LAMP Study 2019 {published data only} + + Li FF, Kam KW, Zhang Y, Tang SM, Young AL, Chen LJ, et al. Differential effects on ocular biometrics by 0.05%, 0.025%, and 0.01% atropine: Low-concentration Atropine for Myopia Progression study. Ophthalmology 2020;127(12):1603-11. + + + Li FF, Tang SM, Kam KW, Chen LJ, Yam J. Effect of 0.05%, 0.025%, and 0.01% atropine eye drops on corneal parameters over one year: Low-concentration Atropine for Myopia Progression (LAMP) study. Investigative Ophthalmology and Visual Science 2019;60(9):ARVO E-abstract 4336. + + + Li FF, Zhang Y, Zhang X, Yip BH, Tang SM, Kam KW, et al. Age effect on treatment responses to 0.05%, 0.025%, and 0.01% atropine: Low-concentration Atropine for Myopia Progression study. Ophthalmology 2021;128(8):1180-7. + + + Yam J, Li, FF, Tang SM, Chen LJ, Tham CC. Low-concentration Atropine for Myopia Progression (LAMP) study phase 2: 0.05% atropine remained the best concentration among 0.05%, 0.025%, and 0.01% atropine over 2 years. Investigative Ophthalmology and Visual Science 2019;60(9):ARVO E-abstract 4814. + + + Yam JC, Jiang Y, Lee J, Li S, Zhang Y, Sun W, et al. The association of choroidal thickening by atropine with treatment effects for myopia: two-year clinical trial of the LAMP study. American Journal of Ophthalmology . 2022;237:130-8. + + + Yam JC, Jiang Y, Tang SM, Law AK, Chan JJ, Wong E, et al. Low-concentration Atropine for Myopia Progression (LAMP) study: a randomized, double-blinded, placebo-controlled trial of 0.05%, 0.025%, and 0.01% atropine eye drops in myopia control. Ophthalmology 2019;126(1):113-24. + + + Yam JC, Li FF, Zhang X, Tang SM, Yip BH, Kam KW, et al. Two-year clinical trial of the Low-concentration Atropine for Myopia Progression (LAMP) study: phase 2 report. Ophthalmology 2020;127(7):910-9. + + + Yam JC, Zhang XJ, Zhang Y, Wang YM, Tang SM, Li FF, et al. Three-year clinical trial of low-concentration atropine for myopia progression study: continued versus washout: phase 3 reportYam JC, Zhang XJ, Zhang Y, Wang YM, Tang SM, Li FF, et al. Ophthalmology 2022;129(3):308-21. + + + + Lu 2015 {published data only} + + Lu YM, Ma SS, Luo M, Liang N. Clinical effect of the midperiphery additional designed lenses combined adjustment training on myopia in childhood. International Eye Science 2015;15(11):1960-3. + + + + Lyu 2020 {published data only} + + Lyu T, Wang L, Zhou L, Qin J, Ma H, Shi M. Regimen study of high myopia-partial reduction orthokeratology. Eye and Contact Lens 2020;46(3):141-6. + + + + MIT Study 2001 {published data only} + + Hsiao CK, Chen CJ, Shih YF, Lin LL, Hung PT, Yao CL, et al. Design and statistical analysis for the Myopia Intervention Trial in Taiwan. In: Lin LLK, Shih YF, Hung PT , editors(s). Myopia Updates II, 7th International Conference on Myopia, Taipei, Taiwan, Nov-Dec, 1998. Springer-Verlag, 2000:161-4. + + + Hsiao CK, Tsai MY, Chen HM. Inference of nested variance components in a longitudinal myopia intervention trial. Statistics in Medicine 2005;24(21):3251-67. + + + Shih YF, Hsiao CK, Chen CJ, Chang CW, Hung PT, Lin LL. An intervention trial on efficacy of atropine and multi-focal glasses in controlling myopic progression. Acta Ophthalmologica Scandinavica 2001;79(3):233-6. + + + + Moriche‐Carretero 2021 {published data only} + + Moriche-Carretero M, Revilla-Amores R, Diaz-Valle D, Morales-Fernández L, Gomez-de-Liaño, R. Myopia progression and axial elongation in Spanish children: efficacy of atropine 0.01% eye-drops. Journal Francais d'Ophtalmologie 2021;44(10):1499-504. + + + + Pärssinen 1989 {published data only} + + Hemminki E, Pärssinen O. Prevention of myopic progress by glasses. Study design and the first-year results of a randomized trial among schoolchildren. American Journal of Optometry and Physiological Optics 1987;64(8):611-6. + + + Pärssinen O, Hemminki E, Klemetti A. Effect of spectacle use and accommodation on myopic progression: final results of a three-year randomised clinical trial among schoolchildren. British Journal of Ophthalmology 1989;73(7):547-51. + + + Pärssinen O, Hemminki E. Spectacle-use, bifocals and prevention of myopic progression. The two-years results of a randomized trial among schoolchildren. Acta Ophthalmologica 1988;185(Suppl):156-61. + + + Pärssinen O, Kauppinen M, Viljanen A. Astigmatism among myopics and its changes from childhood to adult age: a 23-year follow-up study. Acta Ophthalmologica 2015;93(3):276-83. + + + Pärssinen O, Kauppinen M, Viljanen A. The progression of myopia from its onset at age 8-12 to adulthood and the influence of heredity and external factors on myopic progression. A 23-year follow-up study. Acta Ophthalmologica 2014;92(8):730-9. + + + Pärssinen O, Kauppinen M. What is the influence of parents' myopia on their children's myopic progression? A 22-year follow-up study. Acta Ophthalmologica 2017;94(6):579-85. + + + Pärssinen O, Lyyra AL. Myopia and myopic progression among schoolchildren: a three-year follow-up study. Investigative Ophthalmology and Visual Science 1993;34(9):2794-802. + + + Pärssinen O. Astigmatism and school myopia. Acta Ophthalmologica 1991;69(6):786-90. + + + Pärssinen O. Corneal refraction and topography in school myopia. CLAO Journal 1993;19(1):69-72. + + + Pärssinen TO. Long-term connection of myopic progression with different background variables. In: Lin LL, Shih YF, Hung PT , editors(s). Myopia Updates II: 7th International Conference on Myopia, Taipei, Taiwan, 1998. Springer-Verlag, 2000:21-3. + + + Pärssinen TO. Progression of school myopia from its onset at the mean age of 10.9 years: 13-year follow-up study. In: Lin LLK, Shih YF, Hung PT , editors(s). Myopia Updates II: 7th International Conference on Myopia, Taipei, Taiwan, 1998. Springer-Verlag, 2000:25-8. + + + + PIR‐205 Study 2004 {published data only} + + Bartlett JD, Niemann K, Houde B, Allred T, Edmondson MJ, Crockett RS. A tolerability study of pirenzepine ophthalmic gel in myopic children. Journal of Ocular Pharmacology and Therapeutics 2003;19(3):271-9. + + + Bartlett JD, Niemann K, Houde B, Allred T, Edmondson MJ. Safety and tolerability of pirenzepine ophthalmic gel in pediatric, myopic patients. Investigative Ophthalmology and Visual Science 2000;41(13):ARVO E-abstract 1598. + + + Bartlett JD, Voce M, Than TP, Edmondson M, Novack GD. Electronic monitoring system to assess patient adherence in pediatric drug studies. Investigative Ophthalmology and Visual Science 2003;44(13):ARVO E-abstract 1930. + + + Chu R, Cotter S, Kwon S, PIR-205 Investigator Group. Pirenzepine 2% ophthalmic gel retards myopia progression in 8-12 year old children. In: American Academy of Optometry. 2003:170. + + + Cotter SA, Chu RH, Kwon S. Pirenzepine 2% ophthalmic gel retards myopia progression in 8- to 12-year-old children. Optometry 2003;74:382-3. + + + Kwon S, Cotter S, Chu R, Flores Y. Safety and efficacy of 2% pirenzepine ophthalmic gel in children with myopia: year two. In: American Academy of Optometry. 2001:144. + + + Kwon S, Cotter S, Flores Y. Collaborative Assessment of Myopia Progression with pirenzepine (CAMP) study: recruitment underway for FDA (PIR-205) clinical trial. In: American Academy of Optometry. 2000:99. + + + Siatkowski RM, Cotter SA, Crockett RS, Miller JM, Novack GD, Zadnik K, et al. Two-year multicenter, randomized, double-masked, placebo-controlled, parallel safety and efficacy study of 2% pirenzepine ophthalmic gel in children with myopia. Journal of AAPOS 2008;12(4):332-9. + + + Siatkowski RM, Cotter SA, Miller JM, Scher CA, Crockett RS, Novack GD. Pirenzepine 2% ophthalmic gel retards myopic progression in 8-12 year old children. Investigative Ophthalmology and Visual Science 2003;44(13):ARVO E-abstract 4778. + + + Siatkowski RM, Cotter SA, Miller JM, Scher CA, Crockett RS, Novack GD. Safety and efficacy of 2% pirenzepine ophthalmic gel in children with myopia: a 1-year, multicenter, double-masked, placebo-controlled parallel study. Ophthalmology 2004;122(11):1667-74. + + + Siatkowski RM, Cotter SA, Miller JM, Scher CA, Crockett RS, US Pirenzepine Study Group. Pirenzepine 2% ophthalmic gel retards myopic progression in 8-12 year old children over two years. Investigative Ophthalmology and Visual Science 2004;45(13):ARVO E-abstract 2733. + + + Tan DT, Lam D, Chua WH, Crockett RS. Pirenzepine ophthalmic gel (PIR): safety and efficacy for pediatric myopia in a one-year study in Asia. Investigative Ophthalmology and Visual Science 2003;44(13):ARVO E-abstract 801. + + + + Ren 2017 {published data only} + + Ren QJ, Yue H, Wang P, Liu RJ, Lu P. Effects of low concentration atropine and orthokeratology on myopia prevention and control. International Eye Science 2017;17(4):794-6. + + + + ROMIO Study 2012 {published data only}NCT00962208 + + Chan KY, Cheung SW, Cho P. Clinical performance of an orthokeratology lens fitted with the aid of a computer software in Chinese children. Contact Lens and Anterior Eye 2012;35(4):180-4. + + + Cheung SW, Cho P. Long-term effect of orthokeratology on the anterior segment length. Contact Lens and Anterior Eye 2016;39(4):262-5. + + + Cheung SW, Cho P. Validity of axial length measurements for monitoring myopic progression in orthokeratology. Investigative Ophthalmology and Visual Science 2013;54(3):1613-5. + + + Cho P, Cheung SW. Orthokeratology for slowing myopic progression: a randomised controlled trial. Contact Lens and Anterior Eye 2011;34:S2-3. + + + Cho P, Cheung SW. Protective role of orthokeratology in reducing risk of rapid axial elongation: a reanalysis of data from the ROMIO and TO-SEE studies. Investigative Ophthalmology and Visual Science 2017;58(3):1411-6. + + + Cho P, Cheung SW. Retardation of Myopia in Orthokeratology (ROMIO) study: a 2-year randomized clinical trial. Investigative Ophthalmology and Visual Science 2012;53(11):7077-85. + + + + Ruiz‐Pomeda 2018 {published data only} + + Lopes-Ferreira D, Ruiz-Pomeda A, Perez-Sanchez B, Queiros A, Villa-Collar C. Ocular and corneal aberrations changes in controlled randomized clinical trial MiSight R Assessment Study Spain (MASS). BMC Ophthalmology 2021;21(1):112. + + + Ruiz-Pomeda A, Fernandes P, Amorim-de-Sousa A, González-Méijome JM, Prieto-Garrido FL, Pérez-Sánchez B, et al. Light disturbance analysis in the controlled randomized clinical trial MiSight® Assessment Study Spain (MASS). Contact Lens and Anterior Eye 2019;42(2):200-5. + + + Ruiz-Pomeda A, Pérez-Sánchez B, Cañadas P, Prieto-Garrido FL, Gutiérrez-Ortega R, Villa-Collar C. Binocular and accommodative function in the controlled randomized clinical trial MiSight Assessment Study Spain (MASS). Graefes Archives of Clinical and Experimental Ophthalmology 2018;257(1):207-15. + + + Ruiz-Pomeda A, Pérez-Sánchez B, Prieto-Garrido FL, Gutiérrez-Ortega R, Villa-Collar C. MiSight assessment study Spain: adverse events, tear film osmolarity, and discontinuations. Eye and Contact Lens 2018;44 Suppl 2:S180-6. + + + Ruiz-Pomeda A, Pérez-Sánchez B, Valls I, Prieto-Garrido FL, Gutiérrez-Ortega R, Villa-Collar C. MiSight Assessment Study Spain (MASS). A 2-year randomized clinical trial. Graefes Archives of Clinical and Experimental Ophthalmology 2018;256(5):1011-21. + + + Ruiz-Pomeda A, Prieto-Garrido FL, Hernández Verdejo JL, Villa-Collar C. Rebound effect in the Misight Assessment Study Spain (MASS). Current Eye Research 2021;46(8):1223-6. + + + + Sankaridurg 2010 {published data only} + + Donovan L, Sankaridurg P, Ho A, Chen X, Lin Z, Thomas V, et al. Myopia progression in Chinese children is slower in summer than in winter. Optometry and Vision Science 2012;89(8):1196-202. + + + Sankaridurg P, Chen X, Naduvilath T, de la Jara PL, Lin Z, Li L, et al. Adverse events during 2 years of daily wear of silicone hydrogels in children. Optometry and Vision Science 2013;90(9):961-9. + + + Sankaridurg P, Donovan L, Varnas S, Ho A, Chen X, Martinez A, et al. Spectacle lenses designed to reduce progression of myopia: 12-month results. Optometry and Vision Science 2010;87(9):631-41. + + + Sankaridurg P, Holden B, Smith E, Naduvilath T, Chen X, Jara PL, et al. Decrease in rate of myopia progression with a contact lens designed to reduce relative peripheral hyperopia: one-year results. Investigative Ophthalmology and Visual Science 2011;52(13):9362-7. + + + + Sankaridurg 2019 {published data only} + + Sankaridurg P, Bakaraju RC, Naduvilath T, Chen X, Weng R, Tilia D, et al. Myopia control with novel central and peripheral plus contact lenses and extended depth of focus contact lenses: 2 year results from a randomised clinical trial. Ophthalmic and Physiological Optics 2019;39(4):294-307. + + + + Schwartz 1981 {published data only} + + Schwartz JT. A monozygotic cotwin control study of a treatment for myopia. Acta Geneticae Medicae et Gemellologiae 1974;23(spec. nr.):26. + + + Schwartz JT. A monozygotic co-twin control study of a treatment for myopia. Acta Geneticae Medicae et Gemellologiae 1976;25:133-6. + + + Schwartz JT. Results of a monozygotic co-twin control study on a treatment for myopia. Acta Geneticae Medicae et Gemellologiae 1980;29(1):30. + + + Schwartz JT. Results of a monozygotic co-twin control study on a treatment for myopia. Progress in Clinical and Biological Research 1981;Pt C:249-58. + + + + Shih 1999 {published data only} + + Chen CH, Shih YF, Chou AC, Ho TC, Lin LL, Hung PT. The effect of different concentrations of atropine on myopia controlling in myopic children. Investigative Ophthalmology and Visual Science 1997;38:S4537. + + + Shih YF, Chen CH, Chou AC, Ho TC, Lin LL, Hung PT. Effects of different concentrations of atropine on controlling myopia in myopic children. Journal of Ocular Pharmacology and Therapeutics 1999;15(1):85-90. + + + + STAMP Study 2012 {published data only}NCT00335049 + + Berntsen D, Mutti D, Zadnik K. The effect of bifocal add, correction type, and adaptation on accommodative lag in myopic children. In: American Academy of Optometry. 2009. + + + Berntsen D, Mutti DO, Zadnik K. Baseline characteristics of the study of theories about myopia progression (STAMP). In: American Academy of Optometry. 2008. + + + Berntsen DA, Barr CD, Mutti DO, Zadnik K. Peripheral defocus and myopia progression in myopic children randomly assigned to wear single vision and progressive addition lenses. Investigative Ophthalmology and Visual Science 2013;54(8):5761-70. + + + Berntsen DA, Mutti DO, Zadnik K. Study of Theories About Myopia Progression (STAMP) design and baseline data. Optometry and Vision Science 2011;87(11):823-32. + + + Berntsen DA, Mutti DO, Zadnik K. The effect of bifocal add on accommodative lag in myopic children with high accommodative lag. Investigative Ophthalmology and Visual Science 2010;51(12):6104-10. + + + Berntsen DA, Sinnott LT, Mutti DO, Zadnik K. A randomized trial using progressive addition lenses to evaluate theories of myopia progression in children with a high lag of accommodation. Investigative Ophthalmology and Visual Science 2012;53(2):640-9. + + + + Swarbrick 2015 {published data only} + + Swarbrick HA, Alharbi A, Lum E, Watt K. Overnight orthokeratology for myopia control: short-term effects on axial length and refractive error. Contact Lens and Anterior Eye 2011;34:S3. + + + Swarbrick HA, Alharbi A, Watt K, Lum E, Kang P. Myopia control during orthokeratology lens wear in children using a novel study design. Ophthalmology 2015;122(3):620-30. + + + + Tan 2005 {published data only} + + Tan D, Chia A, Han CW, Bun CY. Author reply: one-year multicenter, double-masked, placebo-controlled, parallel safety and efficacy study of 2% pirenzepine ophthalmic gel in children with myopia. Ophthalmology 2012;119(12):2653-4. + + + Tan DT, Lam D, Chua WH, Crockett RS. Pirenzepine ophthalmic gel (PIR): safety and efficacy for pediatric myopia in a one-year study in Asia. Investigative Ophthalmology and Visual Science 2003;44(13):ARVO E-abstract 801. + + + Tan DT, Lam DS, Chua WH, Shu-Ping DF, Crockett RS, Asian Pirenzepine Study Group. One-year multicenter, double-masked, placebo-controlled, parallel safety and efficacy study of 2% pirenzepine ophthalmic gel in children with myopia. Ophthalmology 2005;112(1):84-91. + + + + Tan 2020 {published data only} + + Tan Q, Ng AL, Choy BN, Cheng GP, Woo VC, Cho P. One-year results of 0.01% atropine with orthokeratology (AOK) study: a randomised clinical trial. Ophthalmic and Physiological Optics 2020;40(5):557-66. + + + + Tang 2021 {published data only} + + Tang WT, Li JQ, Zhou LS, Yu Q. Effect of orthokeratology on relative peripheral refraction in adolescent myopia. International Eye Science 2021;21(4):734-7. + + + + Trier 2008 {published data only}NCT00263471 + + Trier K, Ribel-Madsen SM, Cui D, Brøgger Christensen S. Systemic 7-methylxanthine in retarding axial eye growth and myopia progression: a 36-month pilot study. Journal of Ocular Biology, Diseases, and Informatics 2008;1(2-4):85-93. + + + Trier K, Ribel-Madsen SM. Effect of 7-methylxanthine on axial eye growth in myopic children—24 months follow-up. Investigative Ophthalmology and Visual Science 2007;48(13):ARVO E-abstract 4421. + + + Trier K, Ribel-Madsen SM. Effect of 7-methylxanthine on eye growth in myopic children—36 months follow-up. Investigative Ophthalmology and Visual Science 2008;49(13):ARVO E-abstract 2609. + + + + Wang 2017 {published data only} + + Wang YR, Bian HL, Wang Q. Atropine 0.5% eyedrops for the treatment of children with low myopia: a randomized controlled trial. Medicine 2017;96(27):e7371. + + + + Wei 2020 {published data only} + + Wei S, Li SM, An W, Du J, Liang X, Sun Y, et al. Safety and efficacy of low-dose atropine eyedrops for the treatment of myopia progression in Chinese children: a randomized clinical trial. JAMA Ophthalmology 2020;138(11):1178-84. + + + + Yang 2009 {published data only} + + Lan W, Yang Z, Ge J, Liu W, Chen X. The effectiveness of progressive additional lens on Chinese juvenile-onset acquired myopia: the first year report. Ophthalmic and Physiological Optics 2006;26:8. + + + Yang Z, Lan W, Ge J, Liu W, Chen X, Chen L, et al. The effectiveness of progressive addition lenses on the progression of myopia in Chinese children. Ophthalmic and Physiological Optics 2009;29(1):41-8. + + + + Yen 1989 {published data only} + + Yen MY, Liu JH, Kao SC, Shiao CH. Comparison of the effect of atropine and cyclopentolate on myopia. Annals of Ophthalmology 1989;21(5):180-2. + + + + Yi 2015 {published data only} + + Yi S, Huang Y, Yu SZ, Chen XJ, Yi H, Zeng XL. Therapeutic effect of atropine 1% in children with low myopia. Journal of AAPOS 2015;19(5):426-9. + + + + Zhang 2021 {published data only} + + Zhang Y, Sun X, Chen Y. Controlling anisomyopia in children by orthokeratology: a one-year randomised clinical trial. Contact Lens and Anterior Eye 2021;46(1):101537. [DOI: 10.1016/j.clae.2021.101537] + + + + Zhao 2021 {published data only} + + Zhao Q, Hao Q. Clinical efficacy of 0.01% atropine in retarding the progression of myopia in children. Ophthalmic Epidemiology 2021;28(5):376-82. + + + Zhao Q, Hao Q. Comparison of the clinical efficacies of 0.01% atropine and orthokeratology in controlling the progression of myopia in children. Ophthalmic Epidemiology 2021;28(5):376-82. + + + + Zhu 2021 {published data only} + + Zhu Q, Tang Y, Guo L, Tighe S, Zhou Y, Zhang X, et al. Efficacy and safety of 1% atropine on retardation of moderate myopia progression in chinese school children. International Ophthalmology 2021;41(3):1011-7. + + + + + References to studies excluded from this review + + Abraham 1966 {published data only} + + Abraham SV. Control of myopia with tropicamide. Journal of Pediatric Ophthalmology 1966;3:10-22. + + + + ACHIEVE Study 2008 {published data only}NCT00522288 + + Jones-Jordan LA, Chitkara M, Coffey B, Jackson JM, Manny RE, Rah MJ, et al. A comparison of spectacle and contact lens wearing times in the ACHIEVE study. Clinical and Experimental Optometry 2010;93(3):157-63. + + + Rah MJ, Walline JJ, Jones-Jordan LA, Sinnott LT, Jackson JM, ACHIEVE Study Group. Vision specific quality of life of pediatric contact lens wearers. Optometry and Vision Science 2010;87(8):560-6. + + + Walline JJ, Jones LA, Chitkara M, Coffey B, Jackson JM, ACHIEVE Study Group. The Adolescent and Child Health Initiative to Encourage Vision Empowerment (ACHIEVE) study. In: American Academy of Optometry. 2004. + + + Walline JJ, Jones LA, Chitkara M, Coffey B, Jackson JM, ACHIEVE Study Group. The Adolescent and Child Health Initiative to Encourage Vision Empowerment (ACHIEVE) study design and baseline data. Optometry and Vision Science 2006;83(1):37-45. + + + Walline JJ, Jones LA, Sinnott L, Chitkara M, Coffey B, Jackson JM, et al. Soft contact lenses do not increase myopia progression in children. Investigative Ophthalmology and Visual Science 2008;49(13):ARVO E-abstract 2021. + + + Walline JJ, Jones LA, Sinnott L, Chitkara M, Coffey B, Jackson JM, et al. The effect of contact lens wear on children's self-perceptions. In: American Academy of Optometry. 2009. + + + Walline JJ, Jones LA, Sinnott L, Chitkara M, Coffey B, ACHIEVE Study Group. Randomized trial of the effect of contact lens wear on self-perception in children. Optometry and Vision Science 2009;86(3):222-32. + + + Walline JJ, Jones LA, Sinnott L, Manny RE, Gaume A, ACHIEVE Study Group. A randomized trial of the effect of soft contact lenses on myopia progression in children. Investigative Ophthalmology and Visual Science 2008;49(11):4702-6. + + + + ACTRN12620000159954 {published data only} + + ACTRN12620000159954. MALCOLM - MultifocAL COntact Lenses for Myopia. trialsearch.who.int/Trial2.aspx?TrialID=ACTRN12620000159954 (date of registration 13 February 2020). + + + + ACTRN12620001046998 {published data only} + + ACTRN12620001046998. Effect of adding atropine to orthokeratology on eye elongation and myopia progression in children. trialsearch.who.int/Trial2.aspx?TrialID=ACTRN12620001046998 (date of registration 15 October 2020). + + + + Aller 2008 {published data only} + + Aller TA, Wildsoet C. Bifocal soft contact lenses as a possible myopia control treatment: a case report involving identical twins. Clinical and Experimental Optometry 2008;91(4):394-9. + + + + Anderson 2016 {published and unpublished data} + + Anderson HA, Benoit J, Manny RE. Evaluation of progressive addition lens wear and age-related changes in phoria magnitude in myopic children. Investigative Ophthalmology and Visual Science 2016;57(12):ARVO E-abstract 1523. + + + + Andreo 1990 {published data only} + + Andreo LK. Long-term effects of hydrophilic contact lenses on myopia. Annals of Ophthalmology 1990;22(6):224-7. + + + + Avetisov 2019 {published data only} + + Avetisov SE, Myagkov AV, Egorova AV. Correcting progressive myopia with bifocal contact lenses with central zone for distant vision: changes in accommodation and axial length (a preliminary report). Vestnik Oftalmologii 2019;135(1):42-6. + + + + Bakaraju 2015 {published and unpublished data} + + Bakaraju RC, Xu P, Song S, Ma M, Chen X, Jong M, et al. Extended depth-of-focus contact lenses can slow the rate of progression of myopia. Investigative Ophthalmology and Visual Science 2015;56:ARVO E-abstract 1728. + + + + Baldwin 1969 {published data only} + + Baldwin WR, West D, Jolley J, Reid W. Effects of contact lenses on refractive corneal and axial length changes in young myopes. American Journal of Optometry and Archives of American Academy of Optometry 1969;46(12):903-11. + + + + Baltimore Myopia Project 1946 {published data only} + + Betts AE. An evaluation of the Baltimore Myopia Control Project part A. Experimental procedures. Journal of the American Optometric Association 1947;18:481-5. + + + Ewalt HW Jr. The Baltimore Myopia Control Project. Journal of the American Optometric Association 1946;17:167-85. + + + + Baronet 1979 {published data only} + + Baronet, Lecaillon-Thiobon. Longitudinal study of developing myopia and effects of treatment with atropine and Difrarel E [Étude longitudinale des myopies évolutives et effets du traitement par atropine et Difrarel E]. Bulletin des Societes d Ophtalmologie de France 1979;79(4-5):417-21. + + + + Bedrossian 1979 {published data only} + + Bedrossian RH. The effect of atropine on myopia. Annals of Ophthalmology 1971;3(8):891-7. + + + Bedrossian RH. The effect of atropine on myopia. Ophthalmology 1979;86(5):713-9. + + + Bedrossian RH. Treatment of progressive myopia with atropine. In: Weigelin E , editors(s). XX Concilium Ophthalmologicum Germania, International Congress Series No. 146. Amsterdam: Excerpta Medica Foundation, 1966:612-7. + + + + Berkeley OK Study 1983 {published data only}NCT00000123 + + Brand RJ, Polse KA, Schwalbe JS. The Berkeley Orthokeratology Study, Part I. General conduct of the study. American Journal of Optometry and Physiological Optics 1983;60(3):175-86. + + + Polse KA, Brand RJ, Keener RJ, Schwalbe JS, Vastine DW. The Berkeley Orthokeratology Study, Part III. Safety. American Journal of Optometry and Physiological Optics 1983;60(4):321-8. + + + Polse KA, Brand RJ, Schwalbe JS, Vastine DW, Keener RJ. The Berkeley Orthokeratology Study, Part II. Efficacy and duration. American Journal of Optometry and Physiological Optics 1983;60(3):187-98. + + + Polse KA, Brand RJ, Vastine DW, Schwalbe JS. Corneal change accompanying orthokeratology. Plastic or elastic? Results of a randomized controlled clinical trial. Archives of Ophthalmology 1983;101(12):1873-8. + + + Polse KA, Brand RJ. Contact lens effects on ametropia: a current example of the clinical trial. American Journal of Optometry and Physiological Optics 1981;58(4):281-8. + + + + Bier 1988 {published data only} + + Bier N, Lowther G. Myopia Control Study: effect of different contact lens refractive corrections on the progression of myopia. Optometry Today 1988;28:38-40. + + + + Brodstein 1984 {published data only} + + Brodstein RS, Brodstein DE, Olson RJ, Hunt SC, Williams RR. The treatment of myopia with atropine and bifocals: a long-term prospective study. Ophthalmology 1984;91(11):1373-9. + + + + Cambridge Anti‐Myopia Study 2013 {published data only} + + Allen PM, Radhakrishnan H, Price H, Rae S, Theagarayan B, Calver RI, et al. A randomised clinical trial to assess the effect of a dual treatment on myopia progression: the Cambridge Anti-Myopia Study. Ophthalmic and Physiological Optics 2013;33(3):267-76. + + + Price H, Allen PM, Radhakrishnan H, Calver R, Rae S, Theagarayan B, et al. The Cambridge Anti-myopia Study: variables associated with myopia progression. Optometry and Vision Science 2013;90(11):1274-83. + + + + Chan 2014 {published data only} + + Chan KY, Cheung SW, Cho P. Orthokeratology for slowing myopic progression in a pair of identical twins. Contact Lens and Anterior Eye 2014;37(2):116-9. + + + + Chan 2020 {published data only} + + Chan HL, Yu WY, Li SZ, Choi KY, Chan J, Choy BN, et al. Changes of refractive errors in children with different initial predicted myopia progression rates after 6-month 0.01% atropine treatment. Investigative Ophthalmology and Visual Science 2020;61(7):ARVO E-abstract. + + + + Chen 2012 {published data only} + + Chen Z, Niu LL, Xue F, Qu XM, Zhou ZM, Zhou XT, et al. Impact of pupil diameter on axial growth in orthokeratology. Optometry and Vision Science 2012;89(11):1636-40. + + + + Chen 2014 {published data only} + + Chen YH. Clinical observation of the development of juvenile myopia wearing glasses with full correction and under-correction. International Eye Science 2014;14(8):1553-4. + + + + Chen 2016 {published data only} + + Chen Z, Xue F, Zhou J, Qu X, Zhou X. Effects of orthokeratology on choroidal thickness and axial length. Optometry and Vision Science 2016;93(9):1064-71. + + + + Cheung 2018 {published data only} + + Cheung SW, Cho P. Does a two-year period of orthokeratology lead to changes in the endothelial morphology of children? Contact Lens and Anterior Eye 2018;41(2):214-8. + + + + ChiCTR2000034760 {published data only} + + ChiCTR2000034760. A randomized cross-over controlled study on prevention of myopia in children with 0.01% atropine eye drops. trialsearch.who.int/Trial2.aspx?TrialID=ChiCTR2000034760 (date of registration 18 July 2020). + + + + ChiCTR2000038078 {published data only} + + ChiCTR2000038078. Efficacy of artificial natural light in myopia control of school-aged children. trialsearch.who.int/Trial2.aspx?TrialID=ChiCTR2000038078 (date of registration 9 September 2020). + + + + ChiCTR2100052322 {published data only} + + ChiCTR2100052322. Myopia control effect of repeated low-level red-light therapy in Chinese children: a randomized, double-blind, placebo-controlled clinical trial. trialsearch.who.int/Trial2.aspx?TrialID=ChiCTR2100052322 (date of registration 24 October 2021). + + + + ChiCTR‐IOC‐17010525 {published data only} + + ChiCTR-IOC-17010525. Effect of health education on time outdoors in school-aged children: a randomized controlled trial. trialsearch.who.int/Trial2.aspx?TrialID=ChiCTR-IOC-17010525 (date of registration 26 January 2017). + + + + ChiCTR‐OON‐17010470 {published data only} + + ChiCTR-OON-17010470. Investigation on correction of myopia in primary and middle school students. https://trialsearch.who.int/Trial2.aspx?TrialID=ChiCTR-OON-17010470 (date of registration 19 January 2017). + + + + ChiCTR‐TRC‐070000297 {published data only} + + ChiCTR-TRC-07000029. Double-blinded, randomized controlled trial about the influence of new lenses on the progress of children's myopia. trialsearch.who.int/Trial2.aspx?TrialID=ChiCTR-TRC-07000029 (date of registration 30 November 2007). + + + + Cho 2012 {published data only} + + Cho P, Chan B, Cheung SW, Mountford J. Do fenestrations affect the performance of orthokeratology lenses? Optometry and Vision Science 2012;89(4):401-10. + + + + Cho 2017 {published data only}NCT01236742 + + Cho P, Cheung SW. Discontinuation of orthokeratology on eyeball elongation (DOEE). Contact Lens and Anterior Eye 2017;40(2):82-7. + + + + Choi 2005 {published data only} + + Choi YY, Jeong JW, Park DJ. Effect of 1% atropine with tinted bifocal glasses in slowing the progression of myopia in children. In: American Academy of Ophthalmology. 2005:234. + + + + Chou 1997 {published data only} + + Chou AC, Shih YF, Ho TC, Lin LL. The effectiveness of 0.5% atropine in controlling high myopia in children. Journal of Ocular Pharmacology and Therapeutics 1997;13(1):61-7. + + + + Diaz‐Llopis 2018 {published and unpublished data} + + Diaz-Llopis M, Pinazo-Duran MD. Superdiluted atropine at 0.01% reduces progression in children and adolescents. A 5 year study of safety and effectiveness. Archivos de la Sociedad Espanola de Oftalmologia 2018;93:182-5. + + + + Dumbleton 1999 {published data only} + + Dumbleton KA, Chalmers RL, Richter DB, Fonn D. Changes in myopic refractive error with nine months' extended wear of hydrogel lenses with high and low oxygen permeability. Optometry and Vision Science 1999;76(12):845-9. + + + Dumbleton KA, Richter D, Fonn D, Chalmers R. Refractive and keratometric changes following extended wear. In: American Academy of Optometry. 1998:170. + + + + Dyer 1979 {published data only} + + Dyer JA. Role of cycloplegics in progressive myopia. Ophthalmology 1979;86(5):692-4. + + + + Ebri 2007 {published data only} + + Ebri A, Kuper H, Wedner S. Cost-effectiveness of cycloplegic agents: results of a randomized controlled trial in Nigerian children. Investigative Ophthalmology and Visual Science 2007;48(3):1025-31. + + + + Eissa 2018 {published data only} + + Eissa S, Badr Eldin N. ICL versus SMILE in management of anisometropic myopic amblyopia in children. Canadian Journal of Ophthalmology 2018;53:560-7. + + + + Filip 2000 {published data only} + + Filip M, Stefaniu I, Stefan C. Changes in myopic refractive errors after 9 months of extensive wear of hydrogel lenses with high oxygen permeability and compared with those with low permeability. Oftalmologia 2000;51(2):35-40. + + + + French 2016 {published data only} + + French, AN. Increasing children's time spent outdoors reduces the incidence of myopia. Evidence-Based Medicine 2016;21(2):76. + + + + Gimbel 1973 {published data only} + + Gimbel HV. The control of myopia with atropine. Canadian Journal of Ophthalmology 1973;8(4):527-32. + + + + Goss 1984 {published data only} + + Goss DA. Overcorrection as a means of slowing myopic progression. American Journal of Optometry and Physiological Optics 1984;61(2):85-93. + + + + Grosvenor 1991 {published data only} + + Grosvenor T, Perrigin D, Perrigin J, Quintero S. Do rigid gas-permeable contact lenses control the progress of myopia? Contact Lens and Spectacles 1991;6(7):29-35. + + + + He 2015 {published data only} + + He M, Xiang F, Zeng Y, Mai J, Chen Q, Zhang J, et al. Effect of time spent outdoors at school on the development of myopia among children in China: a randomized clinical trial. JAMA 2015;314(11):1142‐8. + + + + He 2016 {published data only} + + He MM, Du YR, Liu QY, Ren CD, Liu JL, Wang QY, et al. Short-term effects of orthokeratology on the development of low-to-moderate myopia in Chinese children. International Eye Science 2016;16(2):237-41. + + + + Horner 1999 {published data only} + + Horner DG, Gross DA, Soni PS, Schroeder TL. Principal axis analysis to determine the contribution of axial elongation to myopia progression. Investigative Ophthalmology and Visual Science 1997;38:ARVO E-abstract 4546. + + + Horner DG, Salmon TO, Soni PS. Junior high age children's myopia progression in soft lenses vs. spectacles. In: American Academy of Optometry. 1994:78. + + + Horner DG, Salmon TO, Soni PS. Junior high age children's myopia progression in soft lenses vs. spectacles. In: American Academy of Optometry. 1995:96. + + + Horner DG, Soni PS, Ross J. Junior high age children's myopia progresses equally in soft lenses and spectacles. Investigative Ophthalmology and Visual Science 1994;35:ARVO E-abstract 735. + + + Horner DG, Soni PS, Salmon TO, Schroeder T. Junior high age children's myopia progression in soft lenses vs. spectacles. Investigative Ophthalmology and Visual Science 1996;37:ARVO E-abstract 4610. + + + Horner DG, Soni PS, Salmon TO, Swartz TS. Myopia progression in adolescent wearers of soft contact lenses and spectacles. Optometry and Vision Science 1999;76(7):474-9. + + + Terry RL, Soni PS, Horner DG. Spectacles, contact lenses, and children's self-concepts: a longitudinal study. Optometry and Vision Science 1997;74(12):1044-8. + + + + Hosaka 1982 {published data only} + + Hosaka A, Abiko Y, Teranishi C. Topical use of labetalol in the treatment of pseudomyopia. In: 2nd International Conference on Myopia, San Francisco, 1978. New York: Myopia International Research Foundation Proceedings, 1982:339-52. + + + + Hosaka 1988 {published data only} + + Hosaka A. Myopia prevention and therapy. The role of pharmaceutical agents. Japanese studies. Acta Ophthalmologica 1988;185(Suppl):130-1. + + + + Hua 2017 {published data only} + + Hua WJ, Jin JX, Wu XY, Yang JW, Jiang X, Gao GP, et al. Elevated light levels in schools have a protective effect on myopia. Ophthalmic and Physiological Optics 2015;35(3):252-62. + + + + Huang 2015a {published data only} + + Huang O, Wei XH. Effect of peripheral vision control technology in the development of juvenile myopia. International Eye Science 2015;15(2):378‐80. + + + + Huang 2020 {published data only} + + Huang PC, Hsiao YC, Tsai CY, Tsai DC, Chen CW, Hsu CC, et al. Protective behaviours of near work and time outdoors in myopia prevalence and progression in myopic children: a 2-year prospective population study. British Journal of Ophthalmology 2020;104(7):956-61. + + + + Huffman 2002 {published data only} + + Huffman KD, Ross S, Pack L, Salmon T, Hoenes R. Visual and optical performance of frequency 55 aspheric vs. spheric contact lenses. In: American Academy of Optometry. 2002. + + + + Jiang 2018 {published data only} + + Jiang J. Effect of orthokeratology, low concentration atropine and frame glasses on juvenile myopia prevention and control. International Eye Science 2018;18:1349-52. + + + + Jiang 2021 {published data only} + + Jiang F, Huang X, Xia H, Wang B, Lu F, Zhang B, et al. The spatial distribution of relative corneal refractive power shift and axial growth in myopic children: orthokeratology versus multifocal contact lens. Frontiers in Neuroscience 2021;15:686932. + + + + Jin 2015 {published data only} + + Jin JX, Hua WJ, Jiang X, Wu XY, Yang JW, Gao GP, et al. Effect of outdoor activity on myopia onset and progression in school-aged children in northeast China: the Sujiatun Eye Care Study. BMC Ophthalmology 2015;15:73. + + + + Jones Jordan 2012 {published data only} + + Jones-Jordan LA, Sinnott LT, Cotter SA, Kleinstein RN, Manny RE, Mutti DO, et al. Time outdoors, visual activity, and myopia progression in juvenile-onset myopes. Investigative Ophthalmology and Visual Science 2012;53(11):7169-75. + + + + Jong 2015 {published data only} + + Jong M, Xu P, Bakaraju RC, Chen X, Sankaridurg P, Ma M, et al. A dose-response relationship between duration of daily lens wear and reduction in rate of axial elongation. Investigative Ophthalmology and Visual Science 2015;56(7):ARVO E-abstract 2941. + + + + JPRN‐jRCTs032180418 {published data only} + + JPRN-jRCTs032180418. Clinical trial on the use of outdoor environment glasses. trialsearch.who.int/Trial2.aspx?TrialID=JPRN-jRCTs032180418 (date of registration 29 July 2016). + + + + Kao 1988 {published data only} + + Kao SC, Lu HY, Liu JH. Atropine effect on school myopia. A preliminary report. Acta Ophthalmologica 1988;185(Suppl):132-3. + + + + Keller 1996 {published data only} + + Keller J. Myopia control with RGPs in children. Contact Lens and Spectacles 1996;11(12):45-8. + + + + Kennedy 1995 {published data only} + + Kennedy RH. Progression of myopia. Transactions of the American Ophthalmological Society 1995;93:755-800. + + + + Khoo 1999 {published data only} + + Khoo CY, Chong J, Chew SJ, Cheng HM, Rajan U. The effect of RGP contact lens wear on school myopia: a three-year study. Investigative Ophthalmology and Visual Science 1998;39:ARVO E-abstract 1289. + + + Khoo CY, Chong J, Rajan U. A 3-year study on the effect of RGP contact lenses on myopic children. Singapore Medical Journal 1999;40(4):230-7. + + + + Kubena 2002 {published data only} + + Kubena T, Kubena K Jr, Kubena K. Effect of TLT absorptive eyeglasses on progression of myopia in children. Ceska a Slovenska Oftalmologie 2002;58(6):377-81. + + + + Lakkis 2006 {published data only} + + Lakkis C, Weidemann K. Evaluation of the performance of photochromic spectacle lenses in children and adolescents aged 10 to 15 years. Clinical and Experimental Optometry 2006;89(4):246-52. + + + + Lam 2018 {published data only} + + Lam AK, Leung SY, Hon Y, Shu-Ho L, Wong KY, Tiu PK, et al. Influence of short-term orthokeratology on corneal tangent modulus: a randomized study. Current Eye Research 2018;43(4):474-81. + + + + Lee 2016 {published data only} + + Lee CY, Sun CC, Lin YF, Lin KK. Effects of topical atropine on intraocular pressure and myopia progression: a prospective comparative study. BMC Ophthalmology 2016;16:114. + + + + Leung 1999 {published data only} + + Brown B, Edwards MH, Leung JT. Is esophoria a factor in slowing of myopia by progressive lenses? Optometry and Vision Science 2002;79(10):638-42. + + + Brown B, Edwards MH. Is esophoria a factor in slowing of myopia by progressive lenses? Author's response. Optometry and Vision Science 2003;80(3):199. + + + Leung JT, Brown B. Progression of myopia in Hong Kong Chinese schoolchildren is slowed by wearing progressive lenses. Optometry and Vision Science 1999;76(6):346-54. + + + Leung JT, Brown B. The effect of progressive lenses on the progression of myopia in Chinese school children. In: American Academy of Optometry. 1997:130. + + + + Li 2005 {published data only} + + Li JP, Wang W. Effect of progressive multifocal lenses for juvenile myopia in 876 cases. International Journal of Ophthalmology 2005;5(3):599-601. + + + + Liang 2008 {published data only} + + Liang CK, Ho TY, Li TC, Hsu WM, Li TM, Lee YC, et al. A combined therapy using stimulating auricular acupoints enhances lower-level atropine eyedrops when used for myopia control in school-aged children evaluated by a pilot randomized controlled clinical trial. Complementary Therapies in Medicine 2008;16(6):305-10. + + + Liang CK, Ho TY, Li TC, Hsu WM, Li TM, Lee YC. Auricular acupoints enhance atropine eyedrops in myopic children. Journal of the Australian Traditional-Medicine Society 2009;15:151. + + + + Lu 2010 {published data only} + + Lu PC, Chen JC. Retarding progression of myopia with seasonal modification of topical atropine. Journal of Ophthalmic and Vision Research 2010;5(2):75-81. + + + + Lu 2019 {published data only} + + Lu Y, Lin Z, Wen L, Gao W, Pan L, Li X, et al. The adaptation and acceptance of defocus incorporated multiple segment lens for Chinese children. American Journal of Ophthalmology 2019;211:207-16. [DOI: 10.1016/j.ajo.2019.12.002] + + + + Lyu 2021 {published data only} + + Lyu Y, Ji N, Fu AC, Wang WQ, Wei L, Qin J, et al. Comparison of administration of 0.02% atropine and orthokeratology for myopia control. Eye and Contact Lens 2021;47(2):81-5. + + + + Ma 2014 {published data only}ISRCTN03252665 + + Ma X, Congdon N, Yi H, Zhou Z, Pang X, Meltzer ME, et al. Safety of spectacles for children's vision: a cluster-randomized controlled trial. American Journal of Ophthalmology 2015;160(5):897-904. + + + Ma X, Zhou Z, Yi H, Pang X, Shi Y, Chen Q, et al. Effect of providing free glasses on children's educational outcomes in China: cluster randomized controlled trial. BMJ 2014;349:g5740. + + + + Mandell 1959 {published data only} + + Mandell RB. Myopia control with bifocal correction. American Journal of Optometry and Archives of American Academy of Optometry 1959;36:652-8. + + + + Marcotte Collard 2019 {published data only} + + Marcotte-Collard R, Simard P, Michaud, L. Clinical evaluation of higher add bifocal soft contact lens to control axial length growth in myopic children. Contact Lens and Anterior Eye 2019;42(6 Suppl 1):e9. + + + + Meythaler 1971 {published data only} + + Meythaler H, Ruppert W. The myopic and miotic effect of pilocarpin and glaucostat [Vergleichende Untersuchungen über den myopisierenden und miotischen Effekt von Pilocarpin und Aceclydine (Glaucostat)]. Graefes Archives of Clinical and Experimental Ophthalmology 1971;181(3):234-45. + + + + Mori 2021 {published data only} + + Mori K, Torii H, Hara Y, Hara M, Yotsukura E, Hanyuda A, et al. Effect of violet light-transmitting eyeglasses on axial elongation in myopic children: a randomized controlled trial. Journal of Clinical Medicine 2021;10(22):5462. + + + + NCT00348166 {published data only} + + NCT00348166. Does undercorrection of myopia retard myopia progression among kindergarten children? clinicaltrials.gov/ct2/show/NCT00348166 (first received 5 October 2011). + + + + NCT00848900 {published data only} + + NCT00848900. Guangzhou outdoor activity longitudinal study. clinicaltrials.gov/show/NCT00848900 (first received 20 February 2009). + + + + NCT02055378 {published and unpublished data} + + NCT02055378. The effect of low-concentration atropine combined with auricular acupoint stimulation in myopia control. clinicaltrials.gov/ct2/show/NCT02055378 (first received 5 February 2014). + + + + NCT03372551 {published data only} + + NCT03372551. Comparison of Somofilcon a daily disposable test contact lens and Somofilcon a daily disposable control contact lens. clinicaltrials.gov/ct2/show/NCT03372551 (first received 23 July 2019). + + + + NCT03512626 {published data only} + + NCT03512626. Clinical evaluation of multifocal intraocular lens: OPTIVIS.TM. clinicaltrials.gov/ct2/show/NCT03512626 (first received 1 May 2018). + + + + NCT03761758 {published data only} + + NCT03761758. Tolerability of a novel spectacle design with reduced peripheral contrast. ichgcp.net/clinical-trials-registry/NCT03761758 (date of registration 1 May 2018). + + + + NCT04126057 {published data only} + + NCT04126057. Myopia assessment of two manufacturing processes (MAPLE). clinicaltrials.gov/ct2/show/NCT04126057 (first received 25 January 2022). + + + + NCT04238897 {published data only} + + NCT04238897. To evaluate the efficacy and safety of aspherical soft contact lens in myopia control. clinicaltrials.gov/ct2/show/NCT04238897 (first received 23 January 2020). + + + + NCT04301323 {published data only} + + NCT04301323. Myopia control with novel eye drops. clinicaltrials.gov/show/NCT04301323 (first received 10 March 2020). + + + + NCT04492397 {published data only} + + NCT04492397. Comparing the performance of two different daily disposable lenses (MIKI). clinicaltrials.gov/ct2/show/NCT04492397 (first received 30 July 2020). + + + + NCT04923841 {published data only} + + NCT04923841. Myopia control using bright light therapy, atropine and myopic defocus. clinicaltrials.gov/show/NCT04923841 (first received 11 June 2021). + + + + NCT05156190 {published data only} + + Morgan IG, Xiang F, Zeng Y, Mai J, Chen Q, Zhang J, et al. Increased outdoor time reduces incident myopia - The Guangzhou Outdoor Activity Longitudinal Study. Investigative Ophthalmology and Visual Science 2014;55(13):ARVO E-abstract 1272. + + + NCT05156190. The impact of bright classroom on myopia (IMPACT). clinicaltrials.gov/ct2/show/NCT05156190 (first received 14 December 2021). + + + + Neetens 1985 {published data only} + + Neetens A, Evens P. The use of bifocals as alternative in the management of low grade myopia. Bulletin de la Societe Belge d Ophtalmologie 1985;214:79-85. + + + + Nesterov 1990 {published data only} + + Nesterov AP, Svirin AV, Lapochkin VI. Drug therapy of progressive myopia. Vestnik Oftalmologii 1990;106(2):25-8. + + + + Ng 2019 {published data only} + + Ng Lk, Tan Q, Cheng Gp, Woo VC, Cho P. Combined atropine with orthokeratology in childhood myopia control (AOK)-A randomized controlled trial. Investigative Ophthalmology and Visual Science 2019;60(9):ARVO E-abstract 3899. + + + + Oakley 1975 {published data only} + + Oakley KH, Young FA. Bifocal control of myopia. American Journal of Optometry and Physiological Optics 1975;52(11):758-64. + + + + Parker 1958 {published data only} + + Parker MW. Protective-corrective program for young myopes. Optometry Weekly 1958;49:681-3. + + + + Perrigin 1990 {published data only} + + Grosvenor T, Perrigin J, Perrigin D, Quintero S. Use of silicone-acrylate contact lenses for the control of myopia: results after two years of lens wear. Optometry and Vision Science 1989;66(1):41-7. + + + Perrigin J, Perrigin D, Quintero S, Grosvenor T. Silicone-acrylate contact lenses for myopia control: 3-year results. Optometry and Vision Science 1990;67(10):764-9. + + + + Pirenzepine 2003 {published data only} + + No author. Pirenzepine for the treatment of myopia [Schärfer sehen mit Pirenzepin]. Deutsche Apotheker Zeitung 2003;143(12):54. + + + + Plowright 2015 {published data only} + + Plowright AJ, Maldonado-Codina C, Howarth GF, Kern J, Morgan PB. Daily disposable contact lenses versus spectacles in teenagers. Optometry and Vision Science 2015;92(1):44-52. + + + + Pritchard 1999 {published data only} + + Pritchard N, Fonn D. Myopia associated with extended wear of low-oxygen-transmissible hydrogel lenses. In: American Academy of Optometry. 1999:169. + + + + Rah 2002 {published data only} + + Rah MJ, Jackson JM, Jones LA, Marsden HJ, Bailey MD, Barr JT. Overnight orthokeratology: preliminary results of the Lenses and Overnight Orthokeratology (LOOK) study. Optometry and Vision Science 2002;79(9):598-605. + + + + Rainey 2000 {published data only} + + Rainey BB, Goss DA. The effect of vision therapy on myopia progression. In: American Academy of Optometry. 2000:283. + + + + Ritchey 2005 {published data only} + + Ritchey ER, Barr JT, Mitchell GL. The comparison of overnight lens modalities (COLM) study. Eye and Contact Lens 2005;31(2):70-5. + + + + Sankaridurg 2003 {published data only} + + Sankaridurg PR, Sweeney DF, Holden BA, Naduvilath T, Velala I, Gora R, et al. Comparison of adverse events with daily disposable hydrogels and spectacle wear: results from a 12-month prospective clinical trial. Ophthalmology 2003;110(12):2327-34. + + + + Santodomingo‐Rubido 2012 {published data only} + + Santodomingo-Rubido J, Villa-Collar C, Gilmartin B, Gutierrez-Ortega R, Sugimoto K. Long-term efficacy of orthokeratology contact lens wear in controlling the progression of childhood myopia. Current Eye Research 2017;42(5):713-20. + + + Santodomingo-Rubido J, Villa-Collar C, Gilmartin B, Gutierrez-Ortega R. Factors preventing myopia progression with orthokeratology correction. Optometry and Vision Science 2013;90(11):1225-36. + + + Santodomingo-Rubido J, Villa-Collar C, Gilmartin B, Gutierrez-Ortega R. Myopia control with orthokeratology contact lenses in Spain: a comparison of vision-related quality-of-life measures between orthokeratology contact lenses and single-vision spectacles. Eye and Contact Lens 2013;39(2):153-7. + + + Santodomingo-Rubido J, Villa-Collar C, Gilmartin B, Gutierrez-Ortega R. Myopia control with orthokeratology contact lenses in Spain: refractive and biometric changes. Investigative Ophthalmology and Visual Science 2012;53(8):5060-5. + + + Santodomingo-Rubido J, Villa-Collar C, Gilmartin B, Gutierrez-Ortega R. Myopia control with orthokeratology contact lenses in Spain (MCOS): design, baseline findings and 12 month data. In: American Academy of Optometry. 2009. + + + Santodomingo-Rubido J, Villa-Collar C, Gilmartin B, Gutierrez-Ortega R. Myopia control with orthokeratology contact lenses in Spain (MCOS): predictive factors associated with myopia progression. Contact Lens and Anterior Eye 2012;35:e16. + + + Santodomingo-Rubido J, Villa-Collar C, Gilmartin B, Gutierrez-Ortega R. Orthokeratology vs. spectacles: adverse events and discontinuations. Optometry and Vision Science 2012;89(8):1133-9. + + + Santodomingo Rubido J, Villa-Collar C. Myopia control with orthokeratology contact lenses in Spain (MCOS): design, baseline findings and 6 month data. In: American Academy of Optometry. 2008. + + + + Savoliuk 1968 {published data only} + + Savoliuk MM. Optical correction and progressive myopia. Vestnik Oftalmologii 1968;81(1):82-3. + + + + Saxena 2021 {published data only} + + Saxena R, Dhiman R, Gupta V, Kumar P, Matalia J, Roy L, et al. Atropine for the treatment of childhood myopia in India: multicentric randomized trial. Ophthalmology 2021;128(9):1367‐9. + + + + Shen 2011 {published data only} + + Shen EP, Hsieh YT, Hsu WC. Axial length and optical coherence tomography (OCT) characteristics of myopic children with atropine treatment. Clinical and Experimental Ophthalmology 2011;39 Suppl 1:68. + + + + Shimmyo 2003 {published data only} + + Shimmyo M, Rho DS. Retardation of myopic progression and axial growth in human children by muscarinic inhibitor. In: American Academy of Ophthalmology. 2003:143-4. + + + + Shum 2003 {published data only} + + Shum P. Control of myopia by using overnight orthokeratology. Investigative Ophthalmology and Visual Science 2003;44(13):ARVO E-abstract 3718. + + + + SMART Study 2009 {published data only} + + Eiden S, Davis R. Stabilization of Myopia by Accelerated Reshaping Technique (SMART) study: one year results. In: American Academy of Optometry. 2009. + + + Gerowitz RS. SMART study: three year outcomes. Contact Lens and Anterior Eye 2012;35(Suppl):e40. + + + + Soni 2006 {published data only} + + Soni PS, Nguyen TT. Overnight orthokeratology experience with XO material. Eye and Contact Lens 2006;32(1):39-45. + + + + Stone 1976 {published data only} + + Stone J, Powell Cullingford G. Myopia control after contact lens wear. British Journal of Physiological Optics 1974;29(3):93-108. + + + Stone J. Contact lens wear in the young myope. British Journal of Physiological Optics 1973;28:90-134. + + + Stone J. The possible influence of contact lenses on myopia. British Journal of Physiological Optics 1976;31(3):89-114. + + + + Sun 2007 {published data only} + + Sun J, Li Y. Study on near-distance reading addition controlling the aggravating of adolescent myopia. Chinese Ophthalmic Research 2007;25(6):462-4. + + + + Syniuta 2001 {published data only} + + Syniuta LA, Isenberg SJ. Atropine and bifocals can slow the progression of myopia in children. Binocular Vision and Strabismus Quarterly 2001;16(3):203-8. + + + + Takano 1964 {published data only} + + Takano J. Treatment of myopia by the instillation of tropicamide. Japanese Journal of Clinical Ophthalmology 1964;18:45-50. + + + + Tan 2012 {published data only} + + Tan D, Chia A, Han CW, Bun CY. Author reply: one-year multicenter, double-masked, placebo-controlled, parallel safety and efficacy study of 2% pirenzepine ophthalmic gel in children with myopia. Ophthalmology 2012;119:2653-4. + + + + Tan 2019 {published data only} + + Tan Q, Ng AI, Cheng GP, Woo VC, Cho P. Combined atropine with orthokeratology for myopia control: study design and preliminary results. Current Eye Research 2019;44(6):671‐8. + + + + Tang 2020 {published data only} + + Tang WT, Tian M, Li SB, Yu Q. Clinical observation of low-dose atropine combined with orthokeratology in the treatment of myopia. International Eye Science 2020;20(6):1044-7. + + + + Tian 2022 {published data only} + + Tian J, Wei S, Li S, An W, Bai W, Liang X, et al. The effect of atropine 0.01% eyedrops on relative peripheral refraction in myopic children. Eye 2022;29:29. [DOI: 10.1038/s41433-021-01923-1] + + + + Tilia 2018 {published data only} + + Tilia D, Sha J, Thomas V, Bakaraju RC. Vision performance and accommodative/binocular function in children wearing prototype extended depth-of-focus contact lenses. Eye Contact Lens 2019;45(4):260-70. + + + + Toki 1960 {published data only} + + Toki T. Treatment of myopia with local use of neosynephrine hydrochloride. Japanese Journal of Clinical Optometry 1960;14:248-52. + + + + Tokoro 1964 {published data only} + + Tokoro T, Kabe S. Treatment of myopia and changes in optical components. I. Topical application of neosynephrine and N-ethyln9gamma-picolyl)-tropamide. Nippon Ganka Gakkai Zasshi 1964;68(13):1958-61. + + + + Tokoro 1965 {published data only} + + Tokoro T, Kabe S. Treatment of the myopia and the changes in optical components. Report II. Full- or under-correction of myopia by glasses. Nippon Ganka Gakkai Zasshi 1965;69(2):140-4. + + + + TO‐SEE Study 2013 {published data only} + + Chen C, Cheung S, Cho P. Toric orthokeratology for slowing eye elongation (TO-SEE) study. Contact Lens and Anterior Eye 2013;36:e10. + + + + Wan 2020 {published data only} + + Wan K, Lau JK, Cheung SW, Cho P. Orthokeratology with increased compression factor (OKIC): study design and preliminary results. BMJ Open Ophthalmology 2020;5(1):e000345. + + + + Wu 2018 {published data only} + + Wu PC, Chen CT, Lin KK, Sun CC, Kuo CN, Huang HM, et al. Myopia prevention and outdoor light intensity in a school-based cluster randomized trial. Ophthalmology 2018;125(8):1239‐50. + + + + Xiao 2009 {published data only} + + Xiao ZG, Tao LJ, Guo Y, Wang P. Effect of rigid gas permeable contact lenses in controlling the progress of high myopia in children. International Journal of Ophthalmology 2009;9(5):991-3. + + + + Yamada 2004 {published data only} + + Yamada Y. Myopia in primary school children. Japanese Journal of Clinical Ophthalmology 2004;58(2):125-9. + + + + Yamaji 1967 {published data only} + + Yamaji R, Sakiyama A, Yoshihara M, Furuta I, Nakamura R. Clinical study of the effect of tropic acid amide on the visual acuity and refraction in myopic children. Part VII. Nippon Ganka Kiyo - Folia Ophthalmologica Japonica - Bulletin of Japanese Ophthalmology 1967;18(3):333-45. + + + Yamaji R, Yoshihara M, Sakiyama A, Ishikawa K, Furuta I. Group therapy with tropic acid amide (Mydrin M) against pseudo-myopia in primary school children. Bulletin of the Osaka Medical School 1967;13(1):42-51. + + + Yamaji R, Yoshihara M, Yoshida I, Nakamura R, Arisawa M. Clinical study on the effect of tropic acid amide on the visual acuity and refraction in myopic children. Nippon Ganka Kiyo - Folia Ophthalmologica Japonica - Bulletin of Japanese Ophthalmology 1968;19(3):419-34. + + + + Yang 2017 {published data only} + + Yang Y, Wang L, Liu WL, Yan J. Comparison of the accommodative response with two refractive corrections for myopic teenagers. International Eye Science 2017;17(2):302-5. + + + + Yi 2011 {published data only} + + Yi JH, Li RR. Influence of near-work and outdoor activities on myopia progression in school children. Chinese Journal of Contemporary Pediatrics 2011;13(1):32-5. + + + + Young 1992 {published data only} + + Young G, Port M. Rigid gas-permeable extended wear: a comparative clinical study. Optometry and Vision Science 1992;69(3):214-26. + + + + Zeng 2009 {published data only}NCT00657670 + + Zeng Y, Keay L, He M, Mai J, Munoz B, Brady C, et al. A randomized, clinical trial evaluating ready-made and custom spectacles delivered via a school-based screening program in China. Ophthalmology 2009;116(10):1839-45. + + + + Zhang 2019 {published data only} + + Zhang HY, Lam CS, Tang WC, To CH. Impact of defocus incorporated multiple segments (DIMS) spectacle lenses on relative peripheral refraction (RPR): a 2-year randomized clinical trial. Investigative Ophthalmology and Visual Science 2019;60(9):ARVO E-abstract 3898. + + + + Zhao 2017 {published and unpublished data} + + Zhao HL, Jiang J, Yu J, Xu HM. Role of short-wavelength filtering lenses in delaying myopia progression and amelioration of asthenopia in juveniles. International Journal of Ophthalmology 2017;10(8):1261-7. + + + + Zhou 2015 {published data only} + + Zhou C, Yan BX. Comparison of accommodative lag between rigid gas permeable contact lens and spectacles in adolescents after 1 year. International Eye Science 2015;15(5):924-7. + + + + Zhou 2016 {published data only} + + Zhou ZX, Xu SS, Yi SP. Clinical effect of orthokeratology for juvenile with myopia astigmatism and its effects on corneal endothelial cells. International Eye Science 2016;16(8):1525-7. + + + + Zhou 2021 {published data only} + + Zhou H, Zhao G, Li Y. Adjunctive effects of orthokeratology and atropine 0.01% eye drops on slowing the progression of myopia. Clinical and Experimental Optometry 2021;105(5):520-6. [DOI: https://dx.doi.org/10.1080/08164622.2021.1943318] + + + + + References to studies awaiting assessment + + Viswanath 2022 {published and unpublished data} + + Viswanath S, Dadeya S, Arora R, Sahu J, Sharda S. To assess the efficacy of 0.01% atropine eye drops in decreasing the progression of myopia in Indian children. Clinical and Experimental Ophthalmology 2022;49(8):841-2. + + + + Wang 2005 {published data only} + + Wang X, Chu R. Wearing progressive addition lenses (PALs) to slow down the progression of juvenile myopia. Investigative Ophthalmology & Visual Science 2005;46(13):ARVO E-abstract 5595. + + + + + References to ongoing studies + + ACTRN12605000633684 {published and unpublished data} + + ACTRN12605000633684. Trial of an experimental soft contact lens designed to inhibit the progression of axial myopia in children. apps.who.int/trialsearch/Trial2.aspx?TrialID=ACTRN12605000633684 (date registered 13 October 2005). + + + + ACTRN12608000566336 {published and unpublished data} + + ACTRN12608000566336. Myopia control lens efficacy trial. www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=83124 (date registered 12 November 2008). + + + + ACTRN12611000499987 {unpublished data only} + + ACTRN12611000499987. Overnight contact lens treatment for myopia (short-sight) progression in children. www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=336636 (date registered 12 May 2011). + + + + ACTRN12611000582954 {published and unpublished data}ACTRN12611000582954 + + ACTRN12611000582954. Myopia control with progressive spectacle lenses trial. www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=343027 (date registered 6 June 2011). + + + + ACTRN12611001148965 {published and unpublished data} + + ACTRN12611001148965. To determine the rate of refractive error change in children wearing multifocal soft contact lens as compared to those wearing single vision soft contact lenses. www.anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12611001148965 (date registered 2 November 2011). + + + + ACTRN12617000598381 {published and unpublished data} + + ACTRN12617000598381. Western Australian ATOM pilot study: atropine for the treatment of myopia. www.anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12617000598381 (date registered 27 April 2017). + + + Lee SS, Mackey DA, Lingham G, Crewe JM, Richards MD, Chen FK, et al. Western Australia Atropine for the Treatment of Myopia (WA-ATOM) study: Rationale, methodology and participant baseline characteristics. Clinical and Experimental Ophthalmology 2020;48(5):569-79. + + + + ACTRN12618000242224 {published and unpublished data} + + ACTRN12618000242224. Contralateral myopia progression trial. anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12618000242224 (date registered 14 February 2018). + + + + Azuara‐Blanco 2020 {published data only} + + Azuara-Blanco A, Logan N, Strang N, Saunders K, Allen PM, Weir R, et al. Low-dose (0.01%) atropine eye-drops to reduce progression of myopia in children: a multicentre placebo-controlled randomised trial in the UK (CHAMP-UK)-study protocol. British Journal of Ophthalmology 2020;104(7):950-5. + + + + ChiCTR1800016504 {published and unpublished data} + + ChiCTR1800016504. Clinical effect of vitamin B12 eye drops on myopia in children. trialsearch.who.int/Trial2.aspx?TrialID=ChiCTR1800016504 (date registered 6 May 2018). + + + + ChiCTR1800017535 {published and unpublished data} + + ChiCTR1800017535. Randomized controlled trial for orthokeratology lens to correct anisomyopia in children. trialsearch.who.int/Trial2.aspx?TrialID=ChiCTR1800017535 (date registered 2 August 2018). + + + + ChiCTR1800017683 {published and unpublished data} + + ChiCTR1800017683. A double-masked comparative study of peripheral defocus lenses. trialsearch.who.int/Trial2.aspx?TrialID=ChiCTR1800017683 (date registered 8 September 2018). + + + + ChiCTR1800018092 {published and unpublished data} + + ChiCTR1800018092. Comparison of myopia control effect between single use ortho-k and combined with 0.01% atropine eye drops in children. trialsearch.who.int/Trial2.aspx?TrialID=ChiCTR1800018092 (date registered 29 July 2018). + + + + ChiCTR1900021316 {published and unpublished data} + + ChiCTR1900021316. Clinical observation for acupuncture in myopia control and its effect on accommodative microfluctuations. trialsearch.who.int/Trial2.aspx?TrialID=ChiCTR1900021316 (date registered 13 February 2019). + + + + ChiCTR2000033904 {published and unpublished data} + + ChiCTR2000033904. Clinical study of combined orthokeratology (OK lens) and 0.01% atropine solution to control myopia progression in children. trialsearch.who.int/Trial2.aspx?TrialID=ChiCTR2000033904 (date registered 16 June 2020). + + + + ChiCTR2000036880 {published and unpublished data} + + ChiCTR2000036880. A multicenter, double-blind, randomized controlled clinical trial for defocused spectacle lenses in controlling progression of high myopia in children. trialsearch.who.int/Trial2.aspx?TrialID=ChiCTR2000036880 (date registered 25 August 2020). + + + + ChiCTR2000036917 {published and unpublished data} + + ChiCTR2000036917. A multicenter, double-blind, randomized controlled clinical trial for defocused soft contact lens in controlling progression of high myopia in children. trialsearch.who.int/Trial2.aspx?TrialID=ChiCTR2000036917 (date registered 25 August 2020). + + + + ChiCTR2000037113 {published and unpublished data} + + ChiCTR2000037113. Precise intervention of progressive myopia in children, adolenscents and young adults—a randomized clinical trial. trialsearch.who.int/Trial2.aspx?TrialID=ChiCTR2000037113 (date registered 27 August 2020). + + + + ChiCTR2000037443 {published and unpublished data} + + ChiCTR2000037443. A randomized parallel controlled trial of the effect of peripheral myopia defocus lens for preventing and controling myopia in children. trialsearch.who.int/Trial2.aspx?TrialID=ChiCTR2000037443 (date registered 28 August 2020). + + + + ChiCTR2000040990 {published and unpublished data} + + ChiCTR2000040990. The effect of myopia control and influence of visual quality in children treated with orthokeratology of aspherical base curve design. trialsearch.who.int/Trial2.aspx?TrialID=ChiCTR2000040990 (date registered 16 December 2020). + + + + ChiCTR2100041788 {published and unpublished data} + + ChiCTR2100041788. The effect of peripheral defocus modifying spectacle lenses on myopia control. trialsearch.who.int/Trial2.aspx?TrialID=ChiCTR2100041788 (date registered 5 January 2021). + + + + ChiCTR‐INR‐17013794 {published and unpublished data} + + ChiCTR-INR-17013794. The effectiveness safety of corneal contact lens used to correct myopia: a multi-center, randomized, open and positive parallel control clinical trials. chictr.org.cn/showprojen.aspx?proj=23702 (date registered 9 December 2017). + + + + ChiCTR‐INR‐17013853 {published and unpublished data} + + ChiCTR-INR-17013853. Effects of orthokeratology and combined with 0.01% atropine on myopia control: a multicenter comparative study. chictr.org.cn/showprojen.aspx?proj=22940 (date registered 11 December 2017). + + + + ChiCTR‐IOR‐17010432 {published and unpublished data} + + ChiCTR-IOR-17010432. Myopia progression with invisible round segment bifocal spectacle lenses. chictr.org.cn/com/25/showprojen.aspx?proj=17727 (date registered 14 January 2017). + + + + ChiCTR‐IOR‐17011993 {published and unpublished data} + + ChiCTR-IOR-17011993. Prospective, masked, contralateral, randomised, crossover dispensing clinical trial to compare the myopia progression rate between myopia control contact lens and single vision contact lenses. chictr.org.cn/showprojen.aspx?proj=20301 (date registered 14 July 2017). + + + + ChiCTR‐IPD‐16008844 {published and unpublished data} + + ChiCTR-IPD-16008844. Clinical study of low concentration atropine in controlling children myopia. chictr.org.cn/showprojen.aspx?proj=14705 (date registered 14 July 2016). + + + + ChiCTR‐TRC‐07000029 {published and unpublished data} + + ChiCTR-TRC-07000029. Double-blinded, randomized controlled trial about the influence of new lenses on the progress of children's myopia. chictr.org.cn/showprojen.aspx?proj=9496 (date registered 30 November 2007). + + + + ChiCTR‐TRC‐07000044 {published and unpublished data} + + ChiCTR-TRC-07000044. Clinical randomized controlled trial of progressive addition lenses on the control of myopia in Chinese adolescents. chictr.org.cn/showproj.aspx?proj=9481 (date registered 12 December 2007). + + + + ChiCTR‐TRC‐09000476 {published and unpublished data} + + ChiCTR-TRC-09000476. Novel spectacle lenses versus single-vision spectacle lenses on the progression of myopia in children: a randomised clinical trial. chictr.org.cn/showprojen.aspx?proj=9058 (date registered 4 August 2009). + + + + ChiCTR‐TRC‐10000914 {published and unpublished data} + + ChiCTR-TRC-10000914. Progression of refractive error in myopic Chinese children wearing commercially-available single vision spectacles. chictr.org.cn/showproj.aspx?proj=8624 (date registered 27 June 2007). + + + + ChiCTR‐TRC‐11001463 {published and unpublished data} + + ChiCTR-TRC-11001463. Efficacy of MyoVision spectacle lenses. chictr.org.cn/showproj.aspx?proj=8076 (date registered 2 August 2011). + + + + ChiCTR‐TRC‐11001746 {published and unpublished data} + + ChiCTR-TRC-11001746. Assessment of myopia progression rates in children wearing either a multifocal centre near or single vision soft contact lens. chictr.org.cn/showprojen.aspx?proj=7799 (date registered 1 December 2011). + + + + ChiCTR‐TRC‐13003396 {published and unpublished data} + + ChiCTR-TRC-13003396. Myopia progression with sedentary-use, small segment, concentric bifocals. chictr.org.cn/showprojen.aspx?proj=6163 (date registered 1 August 2013). + + + + ChiCTR‐TRC‐13004032 {published and unpublished data} + + ChiCTR-TRC-13004032. Chinese university low dose atropine for myopia progression study (CU-LAMP). chictr.org.cn/showprojen.aspx?proj=5535 (date registered 24 December 2014). + + + + ChiCTR‐TRC‐14004227 {published and unpublished data} + + ChiCTR-TRC-14004227. Assessment of rate of progression of myopia with contact lenses in Chinese children. chictr.org.cn/hvshowproject.aspx?id=8971 (date registered 9 August 2016). + + + + ChiCTR‐TRC‐14004990 {published and unpublished data} + + ChiCTR-TRC-14004990. Low concentration atropine to slow myopic progression in children. www.chictr.org.cn/showproj.aspx?proj=4584 (date registered 3 July 2014). + + + + CTRI/2016/11/007450 {published and unpublished data} + + CTRI/2016/11/007450. Atropine eye drops to decrease myopia progression in children. ctri.nic.in/Clinicaltrials/pdf_generate.php?trialid=15817&EncHid=&modid=&compid=%27,%2715817det%27 (date registered 8 November 2016). + + + + CTRI/2019/05/018970 {published data only} + + CTRI/2019/05/018970. Atropine eyedrops for preventing increase in refractive error (shortsight and astigmatism). ctri.nic.in/Clinicaltrials/pdf_generate.php?trialid=27716&EncHid=&modid=&compid=','27716det' (date registered 4 May 2019). + + + + CTRI/2019/10/021538 {published data only} + + CTRI/2019/10/021538. Atropine eyedrops for treatment of increasing shortsight. ctri.nic.in/Clinicaltrials/pdf_generate.php?trialid=27712&EncHid=&modid=&compid=','27712det' (date registered 5 October 2019). + + + + CTRI/2021/10/037447 {published data only} + + CTRI/2021/10/037447. Role of 0.01% atropine in myopia control of high myopic children of Moradabad (India). Unable to source website details. + + + + EUCTR2016‐003340‐37‐IE   {published data only} + + McCrann S, Flitcroft I, Strang NC, Saunders KJ, Logan NS, Lee SS, et al. Myopia Outcome Study of Atropine in Children (MOSAIC): an investigator-led, double-masked, placebo-controlled, randomised clinical trial protocol. HRB Open Research 2019;2:15. + + + + EUCTR2018‐001286‐16‐DK {published and unpublished data} + + EUCTR2018-001286-16-DK. Low-dose atropine for the prevention of nearsightedness in Danish children. trialsearch.who.int/Trial2.aspx?TrialID=EUCTR2018-001286-16-DK (date registered 30 May 2018). + + + + EUCTR2019‐002535‐28‐FR {published data only} + + EUCTR2019-002535-28-FR. Braking effect on myopia with atropine eye drops at 0.01%. trialsearch.who.int/Trial2.aspx?TrialID=EUCTR2019-002535-28-FR (date registered 30 September 2019). + + + + EUCTR2020‐001575‐33‐DE {published data only} + + EUCTR2020-001575-33-DE. Low-dose atropIne for myopia control in children. trialsearch.who.int/Trial2.aspx?TrialID=EUCTR2020-001575-33-DE (date registered 12 February 2021). + + + + EUCTR2020‐002046‐16‐CZ {published data only} + + EUCTR2020-002046-16-CZ. Efficacy, safety and side effects of diluted atropin eye drops in slowing the progression of shortsightedness (myopia) in children. trialsearch.who.int/Trial2.aspx?TrialID=EUCTR2020-002046-16-CZ (date registered 18 May 2020). + + + + EUCTR2020‐003976‐42‐NL {published data only} + + EUCTR2020-003976-42-NL. A large scale study to confirm and expand the information on the safety and effectiveness of atropine in treating the progression of myopia in pediatric subjects. trialsearch.who.int/Trial2.aspx?TrialID=EUCTR2020-003976-42-NL (date registered 7 October 2021). + + + + EUCTR2021‐003373‐64‐ES {published data only} + + EUCTR2021-003373-64-ES. Post-marketing parallel clinical trial to determine the efectiveness and tolerability of DIMS lenses in the control of myopia in pediatric population. trialsearch.who.int/Trial2.aspx?TrialID=EUCTR2021-003373-64-ES (date registered 27 July 2021). + + + + IRCT20100414003714N3 {published and unpublished data} + + IRCT20100414003714N3. Effect of atropine eye drop for inhibition of myopic progression. en.irct.ir/trial/31944 (date registered 7 October 2018). + + + + IRCT20180216038747N1 {published and unpublished data} + + IRCT20180216038747N1. Controlling myopia progression. irct.ir/trial/30096 (date registered 17 April 2018). + + + + ISRCTN36732601 {published and unpublished data} + + ISRCTN36732601. Efficacy, safety and mechanisms of atropine eyedrops in slowing the progression of shortsightedness (myopia) in children. isrctn.com/ISRCTN36732601 (date assigned 4 October 2017). + + + Kobia-Acquah E, Flitcroft I, Loughman J, Loskutova E, Martinez Hernandez G. Relationship between choroidal thickness, axial length, and degree of myopia in European children. Investigative Ophthalmology and Visual Science 2021;62(8):ARVO E-abstract 1386. + + + + JPRN‐jRCTs032200060 {published data only} + + jRCTs032200060. Comparison of myopia control effects by combination therapy with multifocal SCL and atropine 0.01% ophthalmic solution, multifocal SCL monotherapy, combination therapy with sphere SCL and atropine 0.01% ophthalmic solution, versus sphere SCL monotherapy: a 1-year randomized four-armed clinical trial in myopic schoolchildren. rctportal.niph.go.jp/en/detail?trial_id=jRCTs032200060 (date registered 30 June 2020). + + + + JPRN‐jRCTs051180041 {published data only} + + JPRN-jRCTs051180041. Effect of 0.01% atropine eye drops in children with moderate to high grade myopia. trialsearch.who.int/Trial2.aspx?TrialID=JPRN-jRCTs051180041 (date registered 30 January 2019). + + + + JPRN‐jRCTs061180091 {published data only} + + JPRN-jRCTs061180091. The efficacy of 0.01% atropine ophthalmic solution for controlling the progression of childhood myopia (ATOM-J Study). Unable to source website details. + + + + JPRN‐UMIN000005054 {unpublished data only} + + JPRN-UMIN000005054. Clinical trial to evaluate effect of spectacle lens that reduces myopia progression. apps.who.int/trialsearch/Trial2.aspx?TrialID=JPRN-UMIN000005054 (date registered 8 February 2011). + + + + JPRN‐UMIN000007989 {published and unpublished data} + + JPRN-UMIN000007989. Clinical trial to prevent myopia progression by progressive additional soft contact lens compared with monofocal soft contact lens in children. apps.who.int/trialsearch/Trial2.aspx?TrialID=JPRN-UMIN000007989 (date registered 1 June 2012). + + + + JPRN‐UMIN000013698 {published and unpublished data} + + JPRN-UMIN000013698. Examination of the nearsighted progress depression effect of the low-concentrated atropine in the Japanese primary schoolchild. apps.who.int/trialsearch/Trial2.aspx?TrialID=JPRN-UMIN000013698 (date registered 11 April 2014). + + + + JPRN‐UMIN000014362 {published and unpublished data} + + JPRN-UMIN000014362. Examination of the myopia progress suppressive effect by combined treatment of orthokeratology and 0.01% atropine instillation. Unable to source website details. + + + + JPRN‐UMIN000018041 {published and unpublished data} + + JPRN-UMIN000018041. The efficacy of 0.01% atropine ophthalmic solution for controlling the progression of childhood myopia (ATOM-J Study). apps.who.int/trialsearch/Trial2.aspx?TrialID=JPRN-UMIN000018041 (date registered 23 June 2015). + + + + JPRN‐UMIN000019237 {published and unpublished data} + + JPRN-UMIN000019237. Effect of dual-focus soft contact lens wear on myopia progression. apps.who.int/trialsearch/Trial2.aspx?TrialID=JPRN-UMIN000018041 (date registered 23 June 2013). + + + + JPRN‐UMIN000023386 {published and unpublished data} + + JPRN-UMIN000023386. Clinical trial on the use of outdoor environment glasses for a suppressive effect on myopia progression. apps.who.int/trialsearch/Trial2.aspx?TrialID=JPRN-UMIN000023386 (date registered 29 July 2016). + + + + JPRN‐UMIN000027940 {published and unpublished data} + + JPRN-UMIN000027940. Clinical study on the effect of multifocal contact lens on myopia progression in myopia school children. apps.who.int/trialsearch/Trial2.aspx?TrialID=JPRN-UMIN000027940 (date registered 21 July 2017). + + + + Kinoshita 2018 {published data only} + + Kinoshita N, Konno Y, Hamada N, Kanda Y, Shimmura-Tomita M, Kakehashi A. Additive effects of orthokeratology and atropine 0.01% ophthalmic solution in slowing axial elongation in children with myopia: first year results. Japanese Journal of Ophthalmology 2018;62(5):544-53. + + + + Li 2013 {published data only} + + Li SM, Li SY, Liu LR, Guo JY, Chen W, Wang Nl, et al. Full correction and undercorrection of myopia evaluation trial: design and baseline data of a randomized, controlled, double-blind trial. Clinical and Experimental Ophthalmology 2013;41(4):329-38. + + + + Li 2020 {published data only} + + Li Y, Fu Y, Wang K, Liu Z, Shi X, Zhao M. Evaluating the myopia progression control efficacy of defocus incorporated multiple segments (DIMS) lenses and Apollo progressive addition spectacle lenses (PALs) in 6- to 12-year-old children: study protocol for a prospective, multicenter, randomized controlled trial. Trials 2020;21(1):279. + + + + MASS 2018 {published and unpublished data}NCT01917110 + + Ruiz-Pomeda A, Perez-Sanchez B, Canadas P, Prieto-Garrido FL, Gutierrez-Ortega R, Villa-Collar C. Binocular and accommodative function in the controlled randomized clinical trial MiSight Assessment Study Spain (MASS). Graefe's Archive for Clinical and Experimental Ophthalmology 2018;257(1):207-15. + + + Ruiz-Pomeda A, Perez-Sanchez B, Prieto-Garrido FL, Gutierrez-Ortega R, Villa-Collar C. MiSight assessment study Spain: adverse events, tear film osmolarity, and discontinuations. Eye and Contact Lens 2018;12:S180-6. + + + Ruiz-Pomeda A, Perez-Sanchez B, Valls I, Prieto-Garrido FL, Gutierrez-Ortega R, Villa-Collar C. MiSight Assessment Study Spain (MASS). A 2-year randomized clinical trial. Graefes Archive for Clinical & Experimental Ophthalmology 2018;3:1011-21. + + + + NCT00214487 {published and unpublished data} + + NCT00214487. Bifocal soft contact lenses and their effect on myopia progression in children and adolescents. clinicaltrials.gov/ct2/show/NCT00214487 (first received 22 September 2005). + + + + NCT00627874 {published and unpublished data} + + NCT00627874. Trial of myopia prevention using +3D lenses. clinicaltrials.gov/ct2/show/NCT00627874 (first received 4 March 2008). + + + + NCT00762970 {published and unpublished data} + + NCT00762970. Controlling myopia progression with soft contact lenses. clinicaltrials.gov/ct2/show/NCT00762970 (first received 30 September 2008). + + + + NCT01704729 {published and unpublished data} + + NCT01704729. The children's WEAR trial (Phase 1 & 2). clinicaltrials.gov/ct2/show/NCT01704729 (first received 11 October 2012). + + + + NCT01729208 {published and unpublished data} + + NCT01729208. An evaluation of the effectiveness of dual focus soft contact lenses in slowing myopia progression. clinicaltrials.gov/ct2/show/NCT01729208 (first received 20 November 2012). + + + + NCT01787760 {published and unpublished data} + + NCT01787760. Controlling myopia progression with soft contact lenses. clinicaltrials.gov/ct2/show/NCT01787760 (first received 29 July 2015). + + + + NCT01829191 {published and unpublished data} + + NCT01829191. Controlling myopia progression with soft contact lenses (contact lens control). clinicaltrials.gov/ct2/show/NCT01829191 (first received 29 July 2015). + + + + NCT01923675 {published and unpublished data} + + NCT01923675. Myopia: the role of cone opsin mutations & glasses that control axial elongation. clinicaltrials.gov/ct2/show/NCT01923675 (first received 15 August 2013). + + + + NCT02001415 {published and unpublished data} + + NCT02001415. Efficacy study of different lens treatments on Chinese adolescent myopia. clinicaltrials.gov/ct2/show/NCT02001415 (first received 4 December 2013). + + + + NCT02130167 {published and unpublished data} + + NCT02130167. Low concentration atropine for myopia progression in school children. clinicaltrials.gov/ct2/show/NCT02130167 (first received 5 May 2014). + + + + NCT02186184 {published and unpublished data} + + NCT02186184. Effect of orthokeratology versus spectacles on myopia progression in Chinese children: a crossover trial. clinicaltrials.gov/ct2/show/NCT02186184 (first received 10 July 2014). + + + + NCT02206217 {published and unpublished data} + + NCT02206217. Myopia control with the multi-segment lens. clinicaltrials.gov/ct2/show/NCT02206217 (first received 1 August 2014). + + + + NCT02544529 {published and unpublished data} + + NCT02544529. Echothiophate iodide for the prevention of progression of myopia. clinicaltrials.gov/ct2/show/NCT02544529 (first received 9 September 2015). + + + + NCT02643342 {published and unpublished data} + + NCT02643342. A 2-year longitudinal study on the structural and optical effects of orthokeratology treatment on eye. clinicaltrials.gov/ct2/show/NCT02643342 (first received 31 December 2015). + + + + NCT02643758 {published and unpublished data} + + NCT02643758. Myopia control using soft bifocal lenses. clinicaltrials.gov/ct2/show/NCT02643758 (first received 31 December 2015). + + + + NCT02700139 {published and unpublished data} + + NCT02700139. Shamir aspheric ophthalmic lenses (MyLens) for myopic control clinical trial. clinicaltrials.gov/ct2/show/NCT02700139 (first received 7 March 2016). + + + + NCT02955927 {published and unpublished data} + + NCT02955927. Combined atropine with orthokeratology in childhood myopia control (AOK)—a randomized controlled trial. clinicaltrials.gov/ct2/show/NCT02955927 (first received 4 November 2016). + + + + NCT02980445 {published data only} + + He X, Sankaridurg P, Xiong S, Li W, Zhang B, Weng R, et al. Shanghai time outside to reduce myopia trial: design and baseline data. Clinical and Experimental Ophthalmology 2019;47(2):171‐8. + + + NCT02980445. Time outdoors as an intervention for myopia in children. clinicaltrials.gov/show/NCT02980445 (first received 2 December 2016). + + + + NCT03242226 {published and unpublished data} + + NCT03242226. The effect of +3.00ADD on myopia progression in Chinese children. clinicaltrials.gov/ct2/show/NCT03242226 (first received 8 August 2017). + + + + NCT03246464 {published and unpublished data} + + NCT03246464. Clinical study of nearsightedness; treatment with orthokeratology lenses (CONTROL). clinicaltrials.gov/ct2/show/NCT03246464 (first received 11 August 2017). + + + + NCT03329638 {published and unpublished data} + + NCT03329638. A study assessing the efficacy and safety of DE-127 ophthalmic solution in subjects with mild or moderate myopia (APPLE). clinicaltrials.gov/ct2/show/NCT03329638 (first received 6 November 2016). + + + + NCT03334253 {published and unpublished data} + + NCT03334253. Low-dose atropine for treatment of myopia. clinicaltrials.gov/ct2/show/NCT03334253 (first received 7 November 2017). + + + + NCT03350620 {published and unpublished data} + + NCT03350620. CHAMP: study of NVK-002 in children with myopia. clinicaltrials.gov/ct2/show/NCT03350620 (first received 22 November 2017). + + + + NCT03374306 {published and unpublished data} + + NCT03374306. Topical application of low-concentration (0.01%) atropine on the human eye with fast and slow myopia progression rate. clinicaltrials.gov/ct2/show/NCT03374306 (first received 15 December 2017). + + + + NCT03402100 {published and unpublished data} + + NCT03402100. Eye drops study for myopia control in schoolchildren. clinicaltrials.gov/ct2/show/NCT03402100 (first received 18 January 2019). + + + + NCT03413085 {published and unpublished data} + + NCT03413085. To evaluate the efficacy and safety of multifocal soft contact lens in myopia control. clinicaltrials.gov/ct2/show/NCT03413085 (first received 29 January 2018). + + + + NCT03465748 {published and unpublished data} + + NCT03465748. Effectiveness of orthokeratology in myopia control. clinicaltrials.gov/ct2/show/NCT03465748 (first received 14 March 2018). + + + + NCT03508817 {published and unpublished data} + + NCT03508817. Atropine 0.01% eye drops in myopia study. clinicaltrials.gov/ct2/show/NCT03508817 (first received 26 April 2018). + + + + NCT03519490 {published and unpublished data} + + NCT03519490. Can distance center and near center multifocal contact lenses control myopia progression in children? clinicaltrials.gov/ct2/show/NCT03519490 (first received 9 May 2019). + + + + NCT03538002 {published and unpublished data} + + NCT03538002. The effect of blue-light filtering spectacle lenses on myopia progression in schoolchildren. clinicaltrials.gov/ct2/show/NCT03538002 (first received 25 May 2018). + + + + NCT03552016 {published and unpublished data} + + NCT03552016. Evaluation of progression of myopia in children treated with vitamin B2 and outdoor sunlight exposure. clinicaltrials.gov/ct2/show/NCT03552016 (first received 11 June 2018). + + + + NCT03623074 {published and unpublished data} + + NCT03623074. Control of myopia using novel spectacle lens designs (CYPRESS). clinicaltrials.gov/ct2/show/NCT03623074 (first received 9 August 2018). + + + + NCT03681366 {published and unpublished data} + + NCT03681366. Myopia control using optimized optical defocus RCTs. clinicaltrials.gov/ct2/show/NCT03681366 (first received 24 September 2018). + + + + NCT03690089 {published and unpublished data} + + ISRCTN99883695. Low-dose atropine eye drops to reduce progression of short-sightedness (myopia) in children in the United Kingdom. isrctn.com/ISRCTN99883695 (date assigned 25 October 2018). + + + NCT03690089. Low-dose atropine eye drops to reduce progression of myopia in children in the United Kingdom. clinicaltrials.gov/ct2/show/NCT03690089 (first received 1 October 2018). + + + + NCT03690414 {published and unpublished data} + + NCT03690414. Evaluation of short term use of experimental eye drops BHVI2, 0.02% atropine and BHVI2 plus 0.02% atropine eye drops. clinicaltrials.gov/ct2/show/NCT03690414 (first received 1 October 2018). + + + + NCT03865160 {published data only} + + NCT03865160. Low-dose atropIne for myopia control in children. clinicaltrials.gov/ct2/show/NCT03865160 (first received 6 March 2019). + + + + NCT03881358 {published data only} + + NCT03881358. Orthokeratology for high myopia (OHM) study. clinicaltrials.gov/ct2/show/NCT03881358 (first received 19 March 2019). + + + + NCT03911271 {published data only} + + NCT03911271. Low-dose atropine for the prevention of myopia progression in Danish children. clinicaltrials.gov/ct2/show/NCT03911271 (first received 11 April 2019). + + + + NCT03918915 {published data only} + + NCT03918915. The safety and efficacy of SYD-101 in children with myopia. clinicaltrials.gov/ct2/show/NCT03918915 (first received 18 April 2019). + + + + NCT03942419 {published data only} + + NCT03942419. Microdosed atropine 0.1% and 0.01% ophthalmic solutions for reduction of pediatric myopia progression. clinicaltrials.gov/ct2/show/NCT03942419 (first received 8 May 2019). + + + + NCT03949101 {published data only} + + NCT03949101. Atropine for children and adolescent myopia progression study. clinicaltrials.gov/ct2/show/NCT03949101 (first received 14 May 2019). + + + + NCT04048148 {published data only} + + NCT04048148. Myopia progression trial with novel myopia control design spectacle lenses. clinicaltrials.gov/ct2/show/NCT04048148 (first received 7 August 2019). + + + + NCT04173780 {published data only} + + NCT04173780. Topical 0.01% atropine for the control of fast progressing myopia. clinicaltrials.gov/ct2/show/NCT04173780 (first received 22 November 2019). + + + + NCT04293328 {published data only} + + NCT04293328. Monthly replacement orthokeratology for myopia control in young children. clinicaltrials.gov/ct2/show/NCT04293328 (first received 3 March 2020). + + + + NCT04295707 {published data only} + + NCT04295707. Monthly replacement orthokeratology for myopia control in existing lens wearers. clinicaltrials.gov/ct2/show/NCT04295707 (first received 4 March 2020). + + + + NCT04618510 {published data only} + + NCT04618510. SEED-LVPEI India myopia study. clinicaltrials.gov/ct2/show/NCT04618510 (first received 6 November 2020). + + + + NCT04699357 {published data only} + + NCT04699357. The effect and safety of different doses of atropine on myopic progression of highly myopic children: multi-centered randomized clinical trial. clinicaltrials.gov/ct2/show/NCT04699357 (first received 7 January 2021). + + + + NCT04770610 {published data only} + + NCT04770610. Study of OT-101 in treating myopia. clinicaltrials.gov/ct2/show/NCT04770610 (first received 25 February 2021). + + + + NCT04813640 {published data only} + + NCT04813640. Eye length signal with myopia control. clinicaltrials.gov/ct2/show/NCT04813640 (first received 24 March 2021). + + + + NCT04854447 {published data only} + + NCT04854447. Part-time versus full-time spectacles for myopia control (ParMA study). clinicaltrials.gov/ct2/show/NCT04854447 (first received 22 April 2021). + + + + NCT05062031 {published data only} + + NCT05062031. Myopia control in children: comparison of defocus incorporated multiple segments lenses versus atropine 0.05% eyedrops. clinicaltrials.gov/ct2/show/NCT05062031 (first received 30 September 2021). + + + + NCT05134935 {published data only} + + NCT05134935. Defocus (DIMS) spectacles versus ortho-K lenses (OKL) for slowing myopia progression in Danish children aged 6-12 years. clinicaltrials.gov/ct2/show/NCT05134935 (first received 26 November 2021). + + + + NCT05159765 {published data only} + + NCT05159765. Progressive myopia treatment evaluation for naturalVue multifocal contact lens trial. clinicaltrials.gov/ct2/show/NCT05159765 (first received 16 December 2021). + + + + NCT05192824 {published data only} + + NCT05192824. 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Global trends in myopia management attitudes and strategies in clinical practice. Contact Lens and Anterior Eye 2016;39(2):106-16. + + + + Wolffsohn 2019 + + Wolffsohn JS, Kollbaum PS, Berntsen DA, Atchison DA, Benavente A, Bradley A, et al. IMI - clinical myopia control trials and instrumentation report. Investigative Ophthalmology and Visual Science 2019;60(3):M132-60. + + + + Wu 2019 + + Wu PC, Chuang MN, Choi J, Chen H, Wu G, Ohno-Matsui K, et al. Update in myopia and treatment strategy of atropine use in myopia control. Eye 2019;33(1):3-13. + + + + Yepes‐Nunez 2019 + + Yepes-Nuñez JJ, Li SA, Guyatt G, Jack SM, Brozek JL, Beyene J, et al. Development of the summary of findings table for network meta-analysis. Journal of Clinical Epidemiology 2019;115:1-13. + + + + Yu 2022 + + Yu Z, Zhong A, Zhao X, Li D, Duan J. Efficacy and safety of different add power soft contact lenses on myopia progression in children: a systematic review and meta-analysis. 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+ + + 36809656 + + 2023 + 02 + 22 + +
+ + 1532-2998 + + + 2023 + Feb + 21 + + + Stress and health : journal of the International Society for the Investigation of Stress + Stress Health + + Families Under Pressure: A Qualitative Study of Stressors in Families of Children with Congenital Heart Disease. + 10.1002/smi.3240 + + The objective of this study was to better understand the stressors in families of children with congenital heart disease (CHD) to assist with formulating targeted stress management plans for such families. + A descriptive qualitative study was undertaken at a tertiary referral hospital in China. Following purposeful sampling, interviews were conducted with twenty-one parents of children with CHD regarding the stressors in their families. + Following content analysis, eleven themes were generated from the data and categorised into six main domains: the initial stressor and associated hardships, normative transitions, prior strains, the consequences of family efforts to cope, intrafamily and social ambiguity, and sociocultural values. The eleven themes include confusion regarding the disease, hardships encountered during treatment, the heavy financial burden, the unusual growth track of the child due to the disease, normal events becoming abnormal for the family, impaired family functioning, family vulnerability, family resilience, family boundary ambiguity induced by role alteration, a lack of knowledge about community support and family stigma. + Various and complex stressors exist for families of children with CHD. Medical personnel should fully evaluate the stressors and take targeted measures before implementing family stress management practices. It is also necessary to focus on the posttraumatic growth of families of children with CHD and strengthen resilience. Moreover, family boundary ambiguity and a lack of knowledge about community support should not be ignored, and further research is needed to explore these variables. Most importantly, policymakers and healthcare providers should adopt a range of strategies to address the stigma of being in a family of a child with CHD. This article is protected by copyright. All rights reserved. + This article is protected by copyright. All rights reserved. + + + + Zhang + Yi + Y + https://orcid.org/0000-0001-8023-551X + + Department of Nursing, The First Affiliated Hospital of Kunming Medical University, Kunming, China. + + + + Zhou + Hang + H + + Psychiatric Department, The First Affiliated Hospital of Kunming Medical University, Kunming, China. + + + + Bai + Yangjuan + Y + + Cardiology Department, The First Affiliated Hospital of Kunming Medical University, Kunming, China. + + + + Chen + Zhisong + Z + + Cardiology Department, The First Affiliated Hospital of Kunming Medical University, Kunming, China. + + + + Wang + Yanjiao + Y + + Psychiatric Department, The First Affiliated Hospital of Kunming Medical University, Kunming, China. + + + + Hu + Qiulan + Q + + ICU in Geriatric Department, The First Affiliated Hospital of Kunming Medical University, Kunming, China. + + + + Yang + Mingfang + M + + Urology Department, The First Affiliated Hospital of Kunming Medical University, Kunming, China. + + + + Wei + Wei + W + + Neurosurgery Department, The First Affiliated Hospital of Kunming Medical University, Kunming, China. + + + + Ding + Lan + L + + General Surgery Department, The First Affiliated Hospital of Kunming Medical University, Kunming, China. + + + + Ma + Fang + F + + Department of Nursing, The First Affiliated Hospital of Kunming Medical University, Kunming, China. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + England + Stress Health + 101089166 + 1532-3005 + + IM + + Family + congenital heart disease + qualitative research + stressors + +
+ + + + 2023 + 02 + 07 + + + 2022 + 08 + 10 + + + 2023 + 02 + 17 + + + 2023 + 2 + 22 + 13 + 59 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809656 + 10.1002/smi.3240 + + +
+ + + 36809657 + + 2023 + 02 + 22 + +
+ + 1720-8386 + + + 2023 + Feb + 21 + + + Journal of endocrinological investigation + J Endocrinol Invest + + Adrenal insufficiency in thyroid cancer patients treated with tyrosine kinase inhibitors and detected by ACTH stimulation test. + 10.1007/s40618-023-02025-3 + + Advanced thyroid cancer patients treated with tyrosine kinase inhibitors (TKI) can develop several adverse events (AEs), including adrenal insufficiency (AI). + We studied 55 patients treated with TKI for radioiodine-refractory or medullary thyroid cancer. The adrenal function was evaluated during follow-up by performing serum basal ACTH, and basal and ACTH-stimulated cortisol. + Twenty-nine/55 (52.7%) patients developed subclinical AI during TKI treatment as demonstrated by a blunted cortisol response to ACTH stimulation. All cases showed normal values of serum sodium, potassium and blood pressure. All patients were immediately treated, and none showed an overt AI. Cases with AI were all negative for adrenal antibodies and did not show any adrenal gland alteration. Other causes of AI were excluded. The onset time of the AI, as measured in the subgroup with a first negative ACTH test, was < 12 months in 5/9 (55.6%), between 12 and 36 months in 2/9 (22.2%) and > 36 months in 2/9 (22.2%) cases. In our series, the only prognostic factor of AI was the elevated, although moderate, basal level of ACTH when the basal and stimulated cortisol were still normal. The glucocorticoid therapy improved fatigue in most patients. + Subclinical AI can be developed in > 50% of advanced thyroid cancer patients treated with TKI. This AE can develop in a wide period ranging from < 12 to > 36 months. For this reason, AI must be looked for throughout the follow-up to be early recognized and treated. A periodic ACTH stimulation test, every 6-8 months, can be helpful. + © 2023. The Author(s). + + + + Valerio + L + L + http://orcid.org/0000-0001-7723-7020 + + Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Via Paradisa 2, 56124, Pisa, Italy. + + + + Giani + C + C + + Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Via Paradisa 2, 56124, Pisa, Italy. + + + + Matrone + A + A + + Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Via Paradisa 2, 56124, Pisa, Italy. + + + + Pontillo-Contillo + B + B + + Diagnostic and Interventional Radiology Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Paradisa 2, 56124, Pisa, Italy. + + + + Minaldi + E + E + + Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Via Paradisa 2, 56124, Pisa, Italy. + + + + Agate + L + L + + Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Via Paradisa 2, 56124, Pisa, Italy. + + + + Molinaro + E + E + + Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Via Paradisa 2, 56124, Pisa, Italy. + + + + Elisei + R + R + http://orcid.org/0000-0002-5333-9257 + + Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Via Paradisa 2, 56124, Pisa, Italy. rossella.elisei@med.unipi.it. + + + + eng + + + Prot. 2017YTWKWH + PRIN 2017: New insights into the molecular signature of differentiated thyroid cancer: implications for diagnosis, prognosis and therapy + + + + IG 2018 + Associazione Italiana per la Ricerca sul Cancro + + + + Cod 21790 + Associazione Italiana per la Ricerca sul Cancro + + + + + Journal Article + + + 2023 + 02 + 21 + +
+ + Italy + J Endocrinol Invest + 7806594 + 0391-4097 + + IM + + ACTH + Adrenal insufficiency + Adverse event + Cortisol + Thyroid cancer + Tyrosine kinase inhibitors + +
+ + + + 2022 + 08 + 09 + + + 2023 + 01 + 25 + + + 2023 + 2 + 22 + 14 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809657 + 10.1007/s40618-023-02025-3 + 10.1007/s40618-023-02025-3 + + + + Matrone A, Valerio L, Pieruzzi L, Giani C, Cappagli V, Lorusso L, Agate L, Puleo L, Viola D, Bottici V, Del Re M, Molinaro E, Danesi R, Elisei R (2017) Protein kinase inhibitors for the treatment of advanced and progressive radiorefractory thyroid tumors: from the clinical trials to the real life. Best Pract Res Clin Endocrinol Metab 31:319–334 + + 10.1016/j.beem.2017.06.001 + 28911728 + + + + Schlumberger M, Tahara M, Wirth LJ, Robinson B, Brose MS, Elisei R, Habra MA, Newbold K, Shah MH, Hoff AO, Gianoukakis AG, Kiyota N, Taylor MH, Kim SB, Krzyzanowska MK, Dutcus CE, de las Heras B, Zhu J, Sherman SI (2015) Lenvatinib versus placebo in radioiodine-refractory thyroid cancer. New Engl J Med 372:621–630 + + 10.1056/NEJMoa1406470 + 25671254 + + + + Brose MS, Nutting CM, Jarzab B, Elisei R, Siena S, Bastholt L, de la Fouchardiere C, Pacini F, Paschke R, Shong YK, Sherman SI, Smit JW, Chung J, Kappeler C, Pena C, Molnar I, Schlumberger MJ, Investigators D (2014) Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trial. Lancet 384:319–328 + + 10.1016/S0140-6736(14)60421-9 + 24768112 + 4366116 + + + + Wells SA Jr, Robinson BG, Gagel RF, Dralle H, Fagin JA, Santoro M, Baudin E, Elisei R, Jarzab B, Vasselli JR, Read J, Langmuir P, Ryan AJ, Schlumberger MJ (2012) Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: a randomized, double-blind phase III trial. J Clin Oncol 30:134–141 + + 10.1200/JCO.2011.35.5040 + 22025146 + + + + Elisei R, Schlumberger MJ, Muller SP, Schoffski P, Brose MS, Shah MH, Licitra L, Jarzab B, Medvedev V, Kreissl MC, Niederle B, Cohen EE, Wirth LJ, Ali H, Hessel C, Yaron Y, Ball D, Nelkin B, Sherman SI (2013) Cabozantinib in progressive medullary thyroid cancer. J Clin Oncol 31:3639–3646 + + 10.1200/JCO.2012.48.4659 + 24002501 + 4164813 + + + + Matrone A, Prete A, Nervo A, Ragni A, Agate L, Molinaro E, Giani C, Valerio L, Minaldi E, Piovesan A, Elisei R (2021) Lenvatinib as a salvage therapy for advanced metastatic medullary thyroid cancer. J Endocrinol Invest 44:2139–2151 + + 10.1007/s40618-020-01491-3 + 33594641 + + + + Valerio L, Pieruzzi L, Giani C, Agate L, Bottici V, Lorusso L, Cappagli V, Puleo L, Matrone A, Viola D, Romei C, Ciampi R, Molinaro E, Elisei R (2017) Targeted therapy in thyroid cancer: state of the art. Clin Oncol (R Coll Radiol) 29:316–324 + + 10.1016/j.clon.2017.02.009 + 28318881 + + + + Liu B, Ding F, Liu Y, Xiong G, Lin T, He D, Zhang Y, Zhang D, Wei G (2016) Incidence and risk of hypertension associated with vascular endothelial growth factor receptor tyrosine kinase inhibitors in cancer patients: a comprehensive network meta-analysis of 72 randomized controlled trials involving 30013 patients. Oncotarget 7:67661–67673 + + 10.18632/oncotarget.11813 + 27602778 + 5341903 + + + + Resteghini C, Cavalieri S, Galbiati D, Granata R, Alfieri S, Bergamini C, Bossi P, Licitra L, Locati LD (2017) Management of tyrosine kinase inhibitors (TKI) side effects in differentiated and medullary thyroid cancer patients. Best Pract Res Clin Endocrinol Metab 31:349–361 + + 10.1016/j.beem.2017.04.012 + 28911730 + + + + Lodish MB, Stratakis CA (2010) Endocrine side effects of broad-acting kinase inhibitors. Endocr Relat Cancer 17:R233-244 + + 10.1677/ERC-10-0082 + 20603395 + 3039175 + + + + Rivers EP, Blake HC, Dereczyk B, Ressler JA, Talos EL, Patel R, Smithline HA, Rady MY, Wortsman J (1999) Adrenal dysfunction in hemodynamically unstable patients in the emergency department. Acad Emerg Med Off J Soc Acad Emerg Med 6:626–630 + + 10.1111/j.1553-2712.1999.tb00417.x + + + + Barroso-Sousa R, Barry WT, Garrido-Castro AC, Hodi FS, Min L, Krop IE, Tolaney SM (2018) Incidence of endocrine dysfunction following the use of different immune checkpoint inhibitor regimens: a systematic review and meta-analysis. JAMA Oncol 4:173–182 + + 10.1001/jamaoncol.2017.3064 + 28973656 + + + + Del Rivero J, Cordes LM, Klubo-Gwiezdzinska J, Madan RA, Nieman LK, Gulley JL (2019) Endocrine-related adverse events related to immune checkpoint inhibitors: proposed algorithms for management. Oncologist 25(4):290–300 + + 10.1634/theoncologist.2018-0470 + 32297436 + 7160393 + + + + Bilgir O, Kebapcilar L, Bilgir F, Sari I, Oner P, Karaca B, Alacacioglu I (2010) Is there any relationship between imatinib mesylate medication and hypothalamic-pituitary-adrenal axis dysfunction? Int J Clin Pract 64:45–50 + + 10.1111/j.1742-1241.2008.01856.x + 20089016 + + + + Rock EP, Goodman V, Jiang JX, Mahjoob K, Verbois SL, Morse D, Dagher R, Justice R, Pazdur R (2007) Food and Drug Administration drug approval summary: Sunitinib malate for the treatment of gastrointestinal stromal tumor and advanced renal cell carcinoma. Oncologist 12:107–113 + + 10.1634/theoncologist.12-1-107 + 17227905 + + + + Colombo C, De Leo S, Di Stefano M, Vannucchi G, Persani L, Fugazzola L (2019) Primary adrenal insufficiency during lenvatinib or vandetanib and improvement of fatigue after cortisone acetate therapy. J Clin Endocrinol Metab 104:779–784 + + 10.1210/jc.2018-01836 + 30383218 + + + + Monti S, Presciuttini F, Deiana MG, Motta C, Mori F, Renzelli V, Stigliano A, Toscano V, Pugliese G, Poggi M (2021) Cortisol deficiency in Lenvatinib treatment of thyroid cancer: an underestimated, common adverse event. Thyroid 32(1):46–53 + + 34663079 + + + + Bornstein SR, Allolio B, Arlt W, Barthel A, Don-Wauchope A, Hammer GD, Husebye ES, Merke DP, Murad MH, Stratakis CA, Torpy DJ (2016) Diagnosis and treatment of primary adrenal insufficiency: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 101:364–389 + + 10.1210/jc.2015-1710 + 26760044 + + + + USDOHAH S 2010 Common terminology criteria for adverse events (CTCAE) version 4.0. 2010. https://evs.nci.nih.gov/ftp1/CTCAE/CTCAE_4.03_2010-06-14 + + + Viola D, Valerio L, Molinaro E, Agate L, Bottici V, Biagini A, Lorusso L, Cappagli V, Pieruzzi L, Giani C, Sabini E, Passannati P, Puleo L, Matrone A, Pontillo-Contillo B, Battaglia V, Mazzeo S, Vitti P, Elisei R (2016) Treatment of advanced thyroid cancer with targeted therapies: ten years of experience. Endocr Relat Cancer 23:R185-205 + + 10.1530/ERC-15-0555 + 27207700 + + + + Wells SA Jr, Gosnell JE, Gagel RF, Moley J, Pfister D, Sosa JA, Skinner M, Krebs A, Vasselli J, Schlumberger M (2010) Vandetanib for the treatment of patients with locally advanced or metastatic hereditary medullary thyroid cancer. J Clin Oncol 28:767–772 + + 10.1200/JCO.2009.23.6604 + 20065189 + 2834392 + + + + Wedge SR, Ogilvie DJ, Dukes M, Kendrew J, Chester R, Jackson JA, Boffey SJ, Valentine PJ, Curwen JO, Musgrove HL, Graham GA, Hughes GD, Thomas AP, Stokes ES, Curry B, Richmond GH, Wadsworth PF, Bigley AL, Hennequin LF (2002) ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration. Can Res 62:4645–4655 + + + Capdevila J, Newbold K, Licitra L, Popovtzer A, Moreso F, Zamorano J, Kreissl M, Aller J, Grande E (2018) Optimisation of treatment with lenvatinib in radioactive iodine-refractory differentiated thyroid cancer. Cancer Treat Rev 69:164–176 + + 10.1016/j.ctrv.2018.06.019 + 30032061 + + + + Lorusso L, Pieruzzi L, Gabriele M, Nisi M, Viola D, Molinaro E, Bottici V, Elisei R, Agate L (2021) Osteonecrosis of the jaw: a rare but possible side effect in thyroid cancer patients treated with tyrosine-kinase inhibitors and bisphosphonates. J Endocrinol Invest 44:2557–2566 + + 10.1007/s40618-021-01634-0 + 34291429 + 8572199 + + + + Patyna S, Arrigoni C, Terron A, Kim TW, Heward JK, Vonderfecht SL, Denlinger R, Turnquist SE, Evering W (2008) Nonclinical safety evaluation of sunitinib: a potent inhibitor of VEGF, PDGF, KIT, FLT3, and RET receptors. Toxicol Pathol 36:905–916 + + 10.1177/0192623308326151 + 18981453 + + + + Wirth LJ, Robinson B, Boni V, Tan DSW, McCoach C, Massarelli E, Hess LM, Jen MH, Kherani J, Olek E, Subbiah V (2022) Patient-reported outcomes with selpercatinib treatment among patients with RET-mutant medullary thyroid cancer in the phase I/II LIBRETTO-001 trial. 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Lancet Diabetes Endocrinol 9:491–501 + + 10.1016/S2213-8587(21)00120-0 + 34118198 + + + + Drilon A, Laetsch TW, Kummar S, DuBois SG, Lassen UN, Demetri GD, Nathenson M, Doebele RC, Farago AF, Pappo AS, Turpin B, Dowlati A, Brose MS, Mascarenhas L, Federman N, Berlin J, El-Deiry WS, Baik C, Deeken J, Boni V, Nagasubramanian R, Taylor M, Rudzinski ER, Meric-Bernstam F, Sohal DPS, Ma PC, Raez LE, Hechtman JF, Benayed R, Ladanyi M, Tuch BB, Ebata K, Cruickshank S, Ku NC, Cox MC, Hawkins DS, Hong DS, Hyman DM (2018) Efficacy of larotrectinib in TRK fusion-positive cancers in adults and children. N Engl J Med 378:731–739 + + 10.1056/NEJMoa1714448 + 29466156 + 5857389 + + + + +
+ + + 36809658 + + 2023 + 02 + 22 + +
+ + 1720-8386 + + + 2023 + Feb + 21 + + + Journal of endocrinological investigation + J Endocrinol Invest + + Efficacy, feasibility and tolerability of ketogenic diet for the treatment of poor response to bariatric surgery. + 10.1007/s40618-023-02034-2 + + Poor response to bariatric surgery, namely insufficient weight loss (IWL) or weight regain (WR), is a critical issue in the treatment of obesity. The purpose of our study was to assess the efficacy, feasibility, and tolerability of very low-calorie ketogenic diet (VLCKD) for the management of this condition. + A real-life prospective study was conducted on twenty-two patients who experienced poor response after bariatric surgery and followed a structured VLCKD. Anthropometric parameters, body composition, muscular strength, biochemical analyses, and nutritional behavior questionnaires were evaluated. + A significant weight loss (mean 14.1 ± 4.8%), mostly due to fat mass, was observed during VLCKD with the preservation of muscular strength. The weight loss obtained allowed patients with IWL to reach a body weight significantly lower than that obtained at the post-bariatric surgery nadir and to report the body weight of patients with WR at the nadir observed after surgery. The significantly beneficial changes in nutritional behaviors and metabolic profiles were observed without variations in kidney and liver function, vitamins, and iron status. The nutritional regimen was well tolerated, and no significant side effects were detected. + Our data demonstrate the efficacy, feasibility, and tolerability of VLCKD in patients with poor response after bariatric surgery. + © 2023. The Author(s). + + + + Vinciguerra + F + F + http://orcid.org/0000-0001-9916-4272 + + Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy. vinciguerrafederica@gmail.com. + + + + Longhitano + S + S + + Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy. + + + + Carrubba + N + N + + Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy. + + + + Piazza + L + L + + General and Emergency Surgery Department, Garibaldi Hospital, Catania, Italy. + + + + Di Stefano + C + C + + General and Emergency Surgery Department, Garibaldi Hospital, Catania, Italy. + + + + Arpi + M L + ML + + Endocrinology Unit: Garibaldi Hospital, Catania, Italy. + + + + Baratta + R + R + + Endocrinology Unit: Garibaldi Hospital, Catania, Italy. + + + + Hagnäs + M + M + + Rovaniemi Health Center, Rovaniemi and Primary Health Care Unit, Lapland Central Hospital, Rovaniemi, Finland. + + + Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland. + + + + Frittitta + L + L + + Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy. + + + Endocrinology Unit: Garibaldi Hospital, Catania, Italy. + + + Diabetes, Obesity and Dietetic Center, Garibaldi Hospital, Catania, Italy. + + + + eng + + Journal Article + + + 2023 + 02 + 21 + +
+ + Italy + J Endocrinol Invest + 7806594 + 0391-4097 + + IM + + Bariatric surgery + Insufficient weight loss + Poor response + Very-low-calorie ketogenic diet + Weight regain + +
+ + + + 2022 + 10 + 10 + + + 2023 + 02 + 05 + + + 2023 + 2 + 22 + 14 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + 2023 + 2 + 23 + 6 + 0 + + + aheadofprint + + 36809658 + 10.1007/s40618-023-02034-2 + 10.1007/s40618-023-02034-2 + + + + Arterburn DE, Telem DA, Kushner RF, Courcoulas AP (2020) Benefits and risks of bariatric surgery in adults: a review. JAMA 324(9):879–887 (PubMed PMID: 32870301) + + 10.1001/jama.2020.12567 + 32870301 + + + + Sutanto A, Wungu CDK, Susilo H, Sutanto H (2021) Reduction of major adverse cardiovascular events (MACE) after bariatric surgery in patients with obesity and cardiovascular diseases: a systematic review and meta-analysis. Nutrients 13(10):3568 + + 10.3390/nu13103568 + 34684569 + 8537443 + + + + El Ansari W, Elhag W (2021) Weight regain and insufficient weight loss after bariatric surgery: definitions, prevalence, mechanisms, predictors, prevention and management strategies, and knowledge gaps-a scoping review (2021). Obes Surg 31(4):1755–1766 + + 10.1007/s11695-020-05160-5 + 33555451 + 8012333 + + + + Debedat J, Sokolovska N, Coupaye M, Panunzi S, Chakaroun R, Genser L et al (2018) Long-term relapse of type 2 diabetes after Roux-en-Y gastric bypass: prediction and clinical relevance. Diabetes Care 41(10):2086–2095 + + 10.2337/dc18-0567 + 30082327 + + + + Jirapinyo P, Abu Dayyeh BK, Thompson CC (2017) Weight regain after Roux-en-Y gastric bypass has a large negative impact on the Bariatric Quality of Life Index. BMJ Open Gastroenterol 4(1):e000153 + + 10.1136/bmjgast-2017-000153 + 28944069 + 5596836 + + + + Velapati SR, Shah M, Kuchkuntla AR, Abu-Dayyeh B, Grothe K, Hurt RT et al (2018) Weight regain after bariatric surgery: prevalence, etiology, and treatment. Curr Nutr Rep 7(4):329–334 + + 10.1007/s13668-018-0243-0 + 30168043 + + + + Odom J, Zalesin KC, Washington TL, Miller WW, Hakmeh B, Zaremba DL et al (2010) Behavioral predictors of weight regain after bariatric surgery. Obes Surg 20(3):349–356 + + 10.1007/s11695-009-9895-6 + 19554382 + + + + Di Lorenzo N, Antoniou SA, Batterham RL, Busetto L, Godoroja D, Iossa A et al (2020) Clinical practice guidelines of the european association for endoscopic surgery (EAES) on bariatric surgery: update 2020 endorsed by IFSO-EC. EASO and ESPCOP Surg End 34(6):2332–2358 + + 10.1007/s00464-020-07555-y + + + + Busetto L, Dicker D, Azran C, Batterham RL, Farpour-Lambert N, Fried M et al (2017) Practical recommendations of the obesity management task force of the European association for the study of obesity for the post-bariatric surgery medical management. Obes Facts 10(6):597–632 + + 10.1159/000481825 + 29207379 + 5836195 + + + + Castellana M, Biacchi E, Procino F, Casanueva FF, Trimboli P (2021) Very-low-calorie ketogenic diet for the management of obesity, overweight and related disorders. 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+
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+1,136810 @@ + + + + + + 36917181 + + 2023 + 03 + 14 + +
+ + 2379-3708 + + + 2023 + Mar + 14 + + + JCI insight + JCI Insight + + Thyroid hormone modulates hyperoxic neonatal lung injury and mitochondrial function. + 10.1172/jci.insight.160697 + e160697 + + Mitochondrial dysfunction at birth predicts bronchopulmonary dysplasia (BPD) in extremely low birth weight (ELBW) infants. Recently, nebulized thyroid hormone (TH), given as triiodothyronine (T3) was noted to decrease pulmonary fibrosis in adult animals through improved mitochondrial function. We hypothesized that TH may have similar effects on hyperoxia-induced neonatal lung injury and mitochondrial dysfunction. To determine whether intranasal T3 decreases neonatal hyperoxic lung injury in newborn mice, T3 improves mitochondrial function in lung homogenates, neonatal murine lung fibroblasts (NMLF) and umbilical cord-derived mesenchymal stem cells (MSCs) obtained from ELBW infants, and whether neonatal hypothyroxinemia is associated with BPD in ELBW infants. Inhaled T3 (given intranasally) attenuated hyperoxia-induced lung injury and mitochondrial dysfunction in newborn mice. T3 also reduced bioenergetic deficits in UC-MSCs obtained both from infants with no/mild BPD and those with moderate/severe BPD. T3 also increased PGC1α content in lung homogenates of mice exposed to hyperoxia as well as mitochondrial potential in both NMLF and UC-MSCs. ELBW infants who died or developed moderate/severe BPD had lower TT4 compared to survivors with no/mild BPD. TH signaling and function may play a critical role in neonatal lung injury and inhaled T3 supplementation may be useful as a therapeutic strategy for BPD. + + + + Vamesu + Bianca M + BM + + Department of Pediatrics, The University of Alabama at Birmingham, Birmingham, United States of America. + + + + Nicola + Teodora + T + + Department of Pediatrics, The University of Alabama at Birmingham, Birmingham, United States of America. + + + + Li + Rui + R + + Department of Pediatrics, The University of Alabama at Birmingham, Birmingham, United States of America. + + + + Hazra + Snehashis + S + + Department of Pediatrics, The University of Alabama at Birmingham, Birmingham, United States of America. + + + + Matalon + Sadis + S + + Department of Anesthesiology and Perioperative Medicine, The University of Alabama at Birmingham, Birmingham, United States of America. + + + + Kaminski + Naftali + N + + Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, United States of America. + + + + Ambalavanan + Namasivayam + N + + Neonatology, The University of Alabama at Birmingham, Birmingham, United States of America. + + + + Kandasamy + Jegen + J + + Department of Pediatrics, The University of Alabama at Birmingham, Birmingham, United States of America. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + JCI Insight + 101676073 + 2379-3708 + + IM + + Human stem cells + Mitochondria + Pulmonology + +
+ + + + 2023 + 3 + 14 + 12 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917181 + 160697 + 10.1172/jci.insight.160697 + + +
+ + + 36917173 + + 2023 + 03 + 14 + +
+ + 1929-0748 + + 12 + + 2023 + Mar + 14 + + + JMIR research protocols + JMIR Res Protoc + + Development of a ParticipACTION App-Based Intervention for Improving Postsecondary Students' 24-Hour Movement Guideline Behaviors: Protocol for the Application of Intervention Mapping. + + e39977 + + 10.2196/39977 + + The Canadian 24-Hour Movement Guidelines for adults provide specific recommendations for levels of physical activity, sedentary behavior, and sleep (ie, the movement behaviors) required for optimal health. Performance of the movement behaviors is associated with improved mental well-being. However, most postsecondary students do not meet the movement behavior recommendations within the Canadian 24-Hour Movement Guidelines and experience increased stress and declining well-being, suggesting the need for an intervention targeting students' movement behaviors. + We aimed to develop and implement a theory-informed intervention intended to improve the movement behaviors and mental well-being of first-year postsecondary students. + The Intervention Mapping protocol was applied in the development and implementation of the intervention. Intervention Mapping entailed performing a needs assessment, determining the intervention outcomes, selecting theory- and evidence-based change methods and applications, preparing and producing intervention plans and materials, developing the implementation plan, and finally developing an evaluation plan. The Theoretical Domains Framework and the Behavior Change Wheel were also used in conjunction with the Intervention Mapping protocol to ensure a solid theoretical basis for the intervention. This protocol led to the development and implementation of a 6-week, theory-informed ParticipACTION app-based intervention aimed at helping first-year postsecondary students improve their movement behaviors and mental well-being. The developed app content provided students with information on each of the movement behaviors and behavioral strategies (ie, goal setting, action planning, monitoring, and coping planning). The use of Intervention Mapping allowed for the continuous involvement of various multidisciplinary partners and end users, ensuring that the intervention design and implementation was appropriate for the target audience. The feasibility, acceptability, and potential impact of the intervention will be examined in a subsequent proof-of-concept study at 2 Canadian university campuses. + Participant recruitment occurred during September 2021, and the intervention was conducted from October to December 2021. The deadline for completion of the postintervention questionnaire by participants was mid-December 2021. The analysis of data examining the feasibility, acceptability, and potential impact of the intervention began in January 2022, with the publication of the proof-of-concept evaluation expected in 2023. + Intervention Mapping with the Theoretical Domains Framework and Behavior Change Wheel was a useful approach to combine evidence and theoretical concepts to guide the design and implementation of a ParticipACTION app-based intervention targeting postsecondary students' movement behaviors and mental well-being. This process may serve as an example for other researchers developing multiple behavior change app-based interventions. Should the forthcoming evaluation demonstrate the intervention's acceptability, feasibility, and potential impact, the intervention may provide a scalable method of improving postsecondary students' movement behaviors and mental well-being. + RR1-10.2196/39977. + ©Stephanie M Flood, Brooke Thompson, Guy Faulkner, Leigh M Vanderloo, Beth Blackett, Matt Dolf, Amy E Latimer-Cheung, Mary Duggan, Katie M Di Sebastiano, Kirstin N Lane, Melissa C Brouwers, Julia McKenna, Tala Chulak-Bozzer, Daniel Fuller, Geralyn R Ruissen, Shelby L Sturrock, Jennifer R Tomasone. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 14.03.2023. + + + + Flood + Stephanie M + SM + https://orcid.org/0000-0003-4906-9992 + + School of Kinesiology and Health Studies, Queen's University, Kingston, ON, Canada. + + + + Thompson + Brooke + B + https://orcid.org/0000-0002-0023-470X + + School of Kinesiology and Health Studies, Queen's University, Kingston, ON, Canada. + + + + Faulkner + Guy + G + https://orcid.org/0000-0001-8898-2536 + + School of Kinesiology, University of British Columbia, Vancouver, BC, Canada. + + + + Vanderloo + Leigh M + LM + https://orcid.org/0000-0003-4621-3717 + + Department of Science and Evaluation, ParticipACTION, Toronto, ON, Canada. + + + + Blackett + Beth + B + https://orcid.org/0000-0001-7656-0301 + + Student Wellness Services, Queen's University, Kingston, ON, Canada. + + + + Dolf + Matt + M + https://orcid.org/0000-0003-3951-2209 + + Office of Wellbeing Strategy, University of British Columbia, Vancouver, BC, Canada. + + + + Latimer-Cheung + Amy E + AE + https://orcid.org/0000-0002-0442-6848 + + School of Kinesiology and Health Studies, Queen's University, Kingston, ON, Canada. + + + + Duggan + Mary + M + https://orcid.org/0000-0001-9230-4332 + + Canadian Society for Exercise Physiology, Ottawa, ON, Canada. + + + + Di Sebastiano + Katie M + KM + https://orcid.org/0000-0002-4410-6267 + + Department of Sport and Exercise Sciences, Durham University, Durham, United Kingdom. + + + + Lane + Kirstin N + KN + https://orcid.org/0000-0002-3786-8191 + + Canadian Society for Exercise Physiology, Ottawa, ON, Canada. + + + School of Exercise Science, Physical and Health Education, University of Victoria, Victoria, BC, Canada. + + + + Brouwers + Melissa C + MC + https://orcid.org/0000-0002-9699-0269 + + School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada. + + + + McKenna + Julia + J + https://orcid.org/0000-0002-3774-6442 + + School of Kinesiology, University of British Columbia, Vancouver, BC, Canada. + + + + Chulak-Bozzer + Tala + T + https://orcid.org/0000-0001-8313-1249 + + Department of Science and Evaluation, ParticipACTION, Toronto, ON, Canada. + + + + Fuller + Daniel + D + https://orcid.org/0000-0002-2015-2955 + + Department of Community Health and Epidemiology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada. + + + + Ruissen + Geralyn R + GR + https://orcid.org/0000-0003-4943-4857 + + Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, AB, Canada. + + + + Sturrock + Shelby L + SL + https://orcid.org/0000-0003-4795-3258 + + Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. + + + + Tomasone + Jennifer R + JR + https://orcid.org/0000-0003-0446-9706 + + School of Kinesiology and Health Studies, Queen's University, Kingston, ON, Canada. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Canada + JMIR Res Protoc + 101599504 + 1929-0748 + + + 24-Hour Movement Guidelines + app + mHealth + mobile health + mobile phone + multiple behavior change + physical activity + postsecondary students + sedentary behavior + sleep + +
+ + + + 2022 + 05 + 30 + + + 2023 + 01 + 18 + + + 2023 + 01 + 17 + + + 2023 + 3 + 14 + 11 + 55 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917173 + v12i1e39977 + 10.2196/39977 + + +
+ + + 36917167 + + 2023 + 03 + 14 + +
+ + 1438-8871 + + 25 + + 2023 + Mar + 14 + + + Journal of medical Internet research + J Med Internet Res + + Development and Assessment of Assisted Diagnosis Models Using Machine Learning for Identifying Elderly Patients With Malnutrition: Cohort Study. + + e42435 + + 10.2196/42435 + + Older patients are at an increased risk of malnutrition due to many factors related to poor clinical outcomes. + This study aims to develop an assisted diagnosis model using machine learning (ML) for identifying older patients with malnutrition and providing the focus of individualized treatment. + We reanalyzed a multicenter, observational cohort study including 2660 older patients. Baseline malnutrition was defined using the global leadership initiative on malnutrition (GLIM) criteria, and the study population was randomly divided into a derivation group (2128/2660, 80%) and a validation group (532/2660, 20%). We applied 5 ML algorithms and further explored the relationship between features and the risk of malnutrition by using the Shapley additive explanations visualization method. + The proposed ML models were capable to identify older patients with malnutrition. In the external validation cohort, the top 3 models by the area under the receiver operating characteristic curve were light gradient boosting machine (92.1%), extreme gradient boosting (91.9%), and the random forest model (91.5%). Additionally, the analysis of the importance of features revealed that BMI, weight loss, and calf circumference were the strongest predictors to affect GLIM. A BMI of below 21 kg/m2 was associated with a higher risk of GLIM in older people. + We developed ML models for assisting diagnosis of malnutrition based on the GLIM criteria. The cutoff values of laboratory tests generated by Shapley additive explanations could provide references for the identification of malnutrition. + Chinese Clinical Trial Registry ChiCTR-EPC-14005253; https://www.chictr.org.cn/showproj.aspx?proj=9542. + ©Xue Wang, Fengchun Yang, Mingwei Zhu, Hongyuan Cui, Junmin Wei, Jiao Li, Wei Chen. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 14.03.2023. + + + + Wang + Xue + X + https://orcid.org/0000-0001-7612-8586 + + Department of Clinical Nutrition, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. + + + + Yang + Fengchun + F + https://orcid.org/0000-0002-9961-7881 + + Institute of Medical Information, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. + + + + Zhu + Mingwei + M + https://orcid.org/0000-0002-4475-7561 + + Department of General Surgery, Beijing Hospital, National Center of Gerontology, Beijing, China. + + + Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China. + + + Department of Gastrointestinal Surgery, Beijing Hospital, National Center of Gerontology, Beijing, China. + + + + Cui + Hongyuan + H + https://orcid.org/0000-0003-4930-1608 + + Department of General Surgery, Beijing Hospital, National Center of Gerontology, Beijing, China. + + + Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China. + + + Department of Gastrointestinal Surgery, Beijing Hospital, National Center of Gerontology, Beijing, China. + + + + Wei + Junmin + J + https://orcid.org/0000-0002-5798-7120 + + Department of General Surgery, Beijing Hospital, National Center of Gerontology, Beijing, China. + + + Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China. + + + Department of Gastrointestinal Surgery, Beijing Hospital, National Center of Gerontology, Beijing, China. + + + + Li + Jiao + J + https://orcid.org/0000-0001-6391-8343 + + Institute of Medical Information, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. + + + + Chen + Wei + W + https://orcid.org/0000-0001-6886-9923 + + Department of Clinical Nutrition, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Canada + J Med Internet Res + 100959882 + 1438-8871 + + IM + + GLIM + SHAP + Shapley additive explanation + XGBoost + algorithm + diagnose + diagnosis + diagnostic + disease-related malnutrition + elder + global leadership initiative on malnutrition + machine learning + malnutrition + model + nutrition + older adult + older inpatients + risk + visualization + +
+ + + + 2022 + 09 + 04 + + + 2023 + 01 + 10 + + + 2022 + 12 + 05 + + + 2023 + 3 + 14 + 11 + 54 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917167 + v25i1e42435 + 10.2196/42435 + + +
+ + + 36917176 + + 2023 + 03 + 14 + +
+ + 1528-1132 + + + 2023 + Mar + 14 + + + Clinical orthopaedics and related research + Clin Orthop Relat Res + + How Much Perioperative Pain and Dysfunction Underlie the HOOS JR and KOOS JR? + 10.1097/CORR.0000000000002606 + + The Hip Disability and Osteoarthritis Outcome Score Joint Replacement (HOOS JR) and Knee Injury and Osteoarthritis Outcome Score Joint Replacement (KOOS JR) scores represent pain and dysfunction as a single number ranging from 0 (extreme pain and dysfunction) to 100 (no pain or functional limitations). However, scores between 0 and 100 lack a simple interpretation because they reflect varying combinations of pain levels and dysfunction. Given that most adverse events and improvement occur within the first 90 days after surgery, a deeper understanding of the level of pain and dysfunction may reveal missed opportunities for patient care. + (1) What does a given preoperative or postoperative HOOS JR and KOOS JR score indicate about pain and ability to perform daily activities? (2) How much of a change in score (that is, delta) is needed to indicate significant improvement in pain control and daily functioning? + The Michigan Arthroplasty Registry Collaborative Quality Initiative contains more than 95% of THAs and TKAs performed in Michigan. Between January 2017 and March 2019, 84,175 people in the registry underwent primary THA or TKA and were potentially eligible for this retrospective, comparative study of the first 90 postoperative days. Eighty-four percent (70,608 of 84,175) were excluded because their surgeons did not attain a target survey collection proportion of 70% and another 6% (5042) were missing covariate information or surveys, leaving 10% (8525) for analysis. The mean age and percentage of women were 65 ± 11 years and 55% (2060 of 3716), respectively, for patients undergoing THA and 67 ± 9 years and 61% (2936 of 4809), respectively, for those undergoing TKA. There were no clinically meaningful differences between patients who were analyzed and those who were excluded except for lower representation of non-White patients in the analyzed group. For interpretation, patient responses to Question 7 (pain) and Question 6 (function) from the Patient-Reported Outcomes Measurement Information System global items (PROMIS-10) were dichotomized into "much pain" (rating of pain 4 to 10 of 10) versus "less pain" (rating of ≤ 3) and "good function" (able to perform most activities) versus "poor function" (not able to perform most activities) and combined into four pain-function categories. We examined the mean preoperative and postoperative HOOS JR and KOOS JR scores for each pain-function category, adjusted for patient characteristics. We calculated the size of the delta associated with an increase to a more favorable category postoperatively (versus staying in the same or worse category) via multivariable logistic regression that controlled for patient characteristics. + Patients in the least favorable "much pain, poor function" category preoperatively had adjusted mean scores of 40 (95% confidence interval 39 to 41) for both the HOOS JR and KOOS JR. Those with mixed levels of pain and function had mean scores between 46 and 55. Those in the most favorable "less pain, good function" category had means of 60 (95% CI 58 to 62) and 59 (95% CI 58 to 61) for the HOOS JR and KOOS JR, respectively. The adjusted delta to achieve a pain level of ≤ 3 or the ability to perform most activities was 30 (95% CI 26 to 36) on the HOOS JR and 27 (95% CI 22 to 29) on the KOOS JR scales. + These adjusted means of the HOOS JR and KOOS JR provide context for understanding the levels of pain and dysfunction for individuals as well for patients reported in other studies. Potential quality improvement efforts could include tracking the proportion of patients with THA or TKA who achieved a sufficient delta to attain pain levels of ≤ 3 or the ability to perform most activities. Future studies are needed to understand pain and function represented by the HOOS JR and KOOS JR at 1 to 2 years, how these may differ by patient subgroups, and whether scores can be improved through quality improvement efforts. + Level III, therapeutic study. + Copyright © 2023 by the Association of Bone and Joint Surgeons. + + + + Cowen + Mark E + ME + + St. Joseph Mercy Health System, Ypsilanti, MI, USA. + + + + Zheng + Huiyong + H + + Michigan Arthroplasty Registry Collaborative Quality Initiative, Ann Arbor, MI, USA. + + + + Hughes + Richard E + RE + + University of Michigan, Ann Arbor, MI, USA. + + + + Franklin + Patricia D + PD + + Northwestern University Feinberg School of Medicine, Chicago, IL, USA. + + + + Masini + Michael A + MA + + St. Joseph Mercy Health System, Ypsilanti, MI, USA. + + + + Hallstrom + Brian R + BR + + University of Michigan, Ann Arbor, MI, USA. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Clin Orthop Relat Res + 0075674 + 0009-921X + + IM + Each author certifies that there are no funding or commercial associations (consultancies, stock ownership, equity interest, patent/licensing arrangements, etc.) that might pose a conflict of interest in connection with the submitted article related to the author or any immediate family members. All ICMJE Conflict of Interest Forms for authors and Clinical Orthopaedics and Related Research® editors and board members are on file with the publication and can be viewed on request. +
+ + + + 2022 + 09 + 09 + + + 2023 + 01 + 30 + + + 2023 + 3 + 14 + 12 + 2 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917176 + 10.1097/CORR.0000000000002606 + 00003086-990000000-01122 + + + + Ayers DC, Li W, Oatis C, Rosal MC, Franklin PD. Patient-reported outcomes after total knee replacement vary on the basis of preoperative coexisting disease in the lumbar spine and other nonoperatively treated joints. J Bone Joint Surg Am. 2013;95:1833-1837. + + + Centers for Medicare and Medicaid Services. Overview of CJR quality measures, composite quality score, and pay-for-performance methodology. Available at: https://innovation.cms.gov/Files/x/cjr-qualsup.pdf. Accessed April 14, 2022. + + + Darrith B, Khalil LS, Franovic S, et alPreoperative Patient-Reported Outcomes Measurement Information System global health scores predict patients achieving the minimal clinically important difference in the early postoperative time period after total knee arthroplasty. J Am Acad Orthop Surg. 2021;29:e1417-e1426. + + + Franklin PD, Zheng H, Bond C, Lavallee DC. Translating clinical and patient-reported data to tailored shared decision reports with predictive analytics for knee and hip arthritis. Qual Life Res. 2021;30:3171-3178. + + + Gandhi R, Mahomed NN, Cram P, Perruccio AV. Understanding the relationship between 3-month and 2-year pain and function scores after total knee arthroplasty for osteoarthritis. J Arthroplasty. 2018;33:1368-1372. + + + Giesinger JM, Hamilton DF, Jost B, Behrend H, Giesinger K. WOMAC, EQ-5D and Knee Society Score thresholds for treatment success after total knee arthroplasty. J Arthroplasty. 2015;30:2154-2158. + + + Guyatt GH, Osoba D, Wu AW, Wyrwich KW, Norman GR; Clinical Significance Consensus Meeting Group. Methods to explain the clinical significance of health status measures. Mayo Clin Proc. 2002;77:371-383. + + + Hastie TJ, Tibshirani RJ. Generalized Additive Models. Chapman and Hall/CRC; 1990. + + + Hays RD, Bjorner JB, Revicki DA, Spritzer KL, Cella D. Development of physical and mental health summary scores from the Patient-Reported Outcomes Measurement Information System (PROMIS) global items. Qual Life Res. 2009;18:873-880. + + + Hays RD, Reise S, Calderón JL. How much is lost in using single items? J Gen Intern Med. 2012;27:1402-1403. + + + Hughes RE, Hallstrom BR, Cowen ME, Igrisan RM, Singal BM, Share DA. Michigan Arthroplasty Registry Collaborative Quality Initiative (MARCQI) as a model for regional registries in the United States. Orthop Res Rev. 2015;7:47-56. + + + Hughes RE, Hallstrom BR, Zheng H, et al. Michigan Arthroplasty Registry Collaborative Quality Initiative (MARCQI) report: 2012-2016. Available at: https://marcqi.org/marcqi-registry-reports-marcqi-annual-reports/. Accessed October 31, 2022. + + + Hughes RE, Zheng H, Igrisan RM, Cowen ME, Markel DC, Hallstrom BR. The Michigan Arthroplasty Registry Collaborative Quality Initiative experience: improving the quality of care in Michigan. J Bone Joint Surg Am. 2018;100:e143.1-7. + + + Hung M, Bounsanga J, Voss MW, Saltzman CL. Establishing minimum clinically important difference values for the Patient-Reported Outcomes Measurement Information System Physical Function, Hip Disability and Osteoarthritis Outcome Score for Joint Reconstruction, and Knee Injury and Osteoarthritis Outcome Score for Joint Reconstruction in orthopaedics. World J Orthop. 2018;9:41-49. + + + Jayakumar P, Moore MG, Furlough KA, et al. Comparison of an artificial intelligence-enabled patient decision aid vs educational material on decision quality, shared decision-making, patient experience, and functional outcomes in adults with knee osteoarthritis: a randomized clinical trial. JAMA Netw Open. 2021;4:e2037107. + + + Keurentjes JC, Van Tol FR, Fiocco M, et al. Patient acceptable symptom states after total hip or knee replacement at mid-term follow-up: thresholds of the Oxford Hip and Knee Scores. Bone Joint Res. 2014;13:7-13. + + + Khalil LS, Darrith B, Franovic S, Davis JJ, Weir RM, Banka TR. Patient-Reported Outcomes Measurement Information System (PROMIS) Global Health short forms demonstrate responsiveness in patients undergoing knee arthroplasty. J Arthroplasty. 2020;35:1540-1544. + + + Kortlever JTP, Leyton-Mange A, Keulen MHF, et al. PROMIS Physical Function correlates with KOOS, JR in patients with knee pain. J Knee Surg. 2020;33:903-911. + + + Kunze KN, Fontana MA, MacLean CH, Lyman S, McLawhorn AS. Defining the patient acceptable symptom state for the H/KOOS, JR after primary total joint arthroplasty. J Bone Joint Surg Am. 2022;104:345-352. + + + Kuo AC, Giori NJ, Bowe TR, et al Comparing methods to determine the minimal clinically important differences in patient-reported outcome measures for veterans undergoing elective total hip or knee arthroplasty in Veterans Health Administration hospitals. JAMA Surg. 2020;155:404-411. + + + Liew J, Forkman J. A guide to generalized additive models in crop science using SAS and R. Commun Biometry Crop Sci. 2015;10:41-57. + + + Lyman S, Lee Y-Y, Franklin PD, Li W, Cross MB, Padgett DE. Validation of the KOOS, JR: a short-form knee arthroplasty outcomes survey. Clin Orthop Relat Res. 2016;474:1461-1471. + + + Lyman S, Lee Y-Y, Franklin PD, Li W, Mayman DJ, Padgett DE. Validation of the HOOS, JR: a short-form hip replacement survey. Clin Orthop Relat Res. 2016;474:1472-1482. + + + Lyman S, Lee Y-Y, McLawhorn AS, Islam W, MacLean CH. What are the minimal and substantial improvements in the HOOS and KOOS and JR versions after total joint replacement? Clin Orthop Relat Res. 2018;476:2432-2441. + + + Molino J, Harrington J, Racine-Avila J, Aaron R. Deconstructing the minimum clinically important difference (MCID). Orthop Res Rev. 2022;14:35-42. + + + Most J, Hoelen TA, Spekenbrink-Spooren A, Schotanus MGM, Boonen B. Defining clinically meaningful thresholds for patient-reported outcomes in knee arthroplasty. J Arthroplasty. 2022;37:837-844.e3. + + + Nguyen UD, Ayers DC, Li W, Harrold LR, Franklin PD. Preoperative pain and function: profiles of patients selected for total knee arthroplasty. J Arthroplasty. 2016;31:2402. + + + Nwankwo VC, Jiranek WA, Green CL, Allen KD, George SZ, Bettger JP. Resilience and pain catastrophizing among patients with total knee arthroplasty: a cohort study to examine psychological constructs as predictors of postoperative outcomes. Health Qual Life Outcomes. 2021;19:136. + + + Sinclair ST, Klika AK, Jin Y, Piuzzi NS, Cleveland Clinic OME Arthroplasty Group, Higuera CA. The impact of surgeon variability on patient-reported outcomes in total hip arthroplasty. J Arthroplasty. 2022;37:S479-S487.e1. + + + Singh JA, Lemay CA, Nobel L, et al. Association of early postoperative pain trajectories with longer-term pain outcome after primary total knee arthroplasty. JAMA Netw Open. 2019;2:e1915105 + + + Terwee CB, Bot SDM, de Boer MR, et al. Quality criteria were proposed for measurement properties of health status questionnaires. J Clin Epidemiol. 2007;60:34-42. + + + Turner D, Schunemann HJ, Griffith LE, et al. Using the entire cohort in the receiver operating characteristic analysis maximizes precision of the minimal important difference. J Clin Epidemiol. 2009;62:374-379. + + + Turner D, Schunemann HJ, Griffith LE, et al. The minimal detectable change cannot reliably replace the minimal important difference. J Clin Epidemiol. 2010;63:28-36. + + + Yale New Haven Health Services Corporation/Center for Outcomes Research & Evaluation (YNHHSC/CORE). Hospital-level risk-standardized complication rate following elective primary total hip arthroplasty (THA) and/or total knee arthroplasty (TKA) measure methodology report. Available at: https://www.qualitynet.org/inpatient/measures/complication/methodology. Accessed November 11, 2020. + + + Youden WJ. Index for rating diagnostic tests. Cancer. 1950;3:32-35. + + + +
+ + + 36917189 + + 2023 + 03 + 14 + +
+ + 1432-1335 + + + 2023 + Mar + 14 + + + Journal of cancer research and clinical oncology + J Cancer Res Clin Oncol + + New insights into breast microcalcification for poor prognosis: NACT cohort and bone metastasis evaluation cohort. + 10.1007/s00432-023-04668-4 + + The study aimed to analyze the poor prognosis of microcalcification in breast cancer (BC), including the pathological complete response (pCR) to neoadjuvant chemotherapy (NACT) and the risk of bone metastases. + 313 breast cancer patients received NACT to evaluate pCR and 1182 patients from a multicenter database to assess bone metastases were retrospectively included. Two groups were divided according to the presence or absence of mammography microcalcification. Clinical data, image characteristics, neoadjuvant treatment response, bone involvement, and follow-up information were recorded. The pCR and bone metastases were compared between subgroups using the Mann-Whitney and χ2 tests and logistic regression, respectively. + Mammographic microcalcification was associated with a lower pCR than uncalcified BC in the NACT cohort (20.6% vs 31.6%, P = 0.029). Univariate and multivariate analysis suggested that calcification was a risk factor for poor NACT response [OR = 1.780, 95%CI (1.065-2.974), P = 0.028], [OR = 2.352, 95%CI (1.186-4.667), P = 0.014]. Microcalcification was more likely to be necrosis on MRI than those without microcalcification (53.0% vs 31.7%, P < 0.001), multivariate analysis indicated that tumor necrosis was also a risk factor for poor NACT response [OR = 2.325, 95%CI (1.100-4.911), P = 0.027]. Age, menopausal status, breast density, mass, molecular, and pathology type were not significantly associated with non-pCR risk assessment. In a multicenter cohort of 1182 patients with pathologically confirmed BC, those with microcalcifications had a higher proportion of bone metastases compared to non-calcified BC (11.6% vs 4.9%, P < 0.001). Univariate and multivariate analysis showed that microcalcification was an independent risk factor for bone metastasis [OR = 2.550, 95%CI (1.620-4.012), P < 0.001], [OR = 2.268(1.263-4.071), P = 0.006)]. Osteolytic bone metastases predominated but there was no statistical difference between the two groups (78.9% vs 60.7%, P = 0.099). Calcified BC was mainly involved in axial bone, but was more likely to involve the whole-body bone than non-calcified BC (33.8% vs 10.7%, P = 0.021). + This study provides important insights into the poor prognosis of microcalcification, not only in terms of poor response to NACT but also the risk factor of bone metastases. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Hu + Yangling + Y + + Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China. + + + + Mao + Lijuan + L + + Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China. + + + + Wang + Mengyi + M + + Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China. + + + + Li + Zhenqiu + Z + + Department of Radiology, The Panyu Fifth Hospital, Guangzhou, China. + + + + Li + Meizhi + M + + Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China. + + + + Wang + Chaoyang + C + + Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China. + + + + Ji + Lin + L + + Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China. + + + + Zeng + Hui + H + http://orcid.org/0000-0002-3715-8317 + + Department of Radiology, Nanfang Hospital, Southern Medical University, Guangzhou, China. zh491157591@163.com. + + + + Zhang + Xiaoling + X + http://orcid.org/0000-0003-3390-7699 + + Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China. zhxiaol6@mail.sysu.edu.cn. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + J Cancer Res Clin Oncol + 7902060 + 0171-5216 + + IM + + Bone metastases + Breast MRI + Complete pathological response + Mammography + Microcalcification + Necrosis + +
+ + + + 2022 + 10 + 05 + + + 2023 + 02 + 23 + + + 2023 + 3 + 14 + 12 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917189 + 10.1007/s00432-023-04668-4 + 10.1007/s00432-023-04668-4 + + + + Azam S, Eriksson M, Sjölander A, Gabrielson M, Hellgren R, Czene K et al (2021) Mammographic microcalcifications and risk of breast cancer. Br J Cancer 125(5):759–765 + + 34127810 + 8405644 + 10.1038/s41416-021-01459-x + + + + Bado IL, Zhang W, Hu J, Xu Z, Wang H, Sarkar P et al (2021) The bone microenvironment increases phenotypic plasticity of ER(+) breast cancer cells. Dev Cell 56(8):1100-1117 e1109 + + 33878299 + 8062036 + 10.1016/j.devcel.2021.03.008 + + + + Chiou AE, Liu C, Moreno-Jiménez I, Tang T, Wagermaier W, Dean MN et al (2021) Breast cancer-secreted factors perturb murine bone growth in regions prone to metastasis. Sci Adv. https://doi.org/10.1126/sciadv.abf2283 + + 10.1126/sciadv.abf2283 + 33990324 + 8121433 + + + + Choi S, Friedrichs J, Song YH, Werner C, Estroff LA, Fischbach C (2019) Intrafibrillar, bone-mimetic collagen mineralization regulates breast cancer cell adhesion and migration. Biomaterials 198:95–106 + + 29759731 + 10.1016/j.biomaterials.2018.05.002 + + + + Cortazar P, Zhang L, Untch M, Mehta K, Costantino JP, Wolmark N et al (2014) Pathological complete response and long-term clinical benefit in breast cancer: the CTNeoBC pooled analysis. Lancet 384(9938):164–172 + + 24529560 + 10.1016/S0140-6736(13)62422-8 + + + + Cox RF, Hernandez-Santana A, Ramdass S, McMahon G, Harmey JH, Morgan MP (2012) Microcalcifications in breast cancer: novel insights into the molecular mechanism and functional consequence of mammary mineralisation. 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J Natl Cancer Inst 105(5):321–333 + + 23297042 + 10.1093/jnci/djs528 + + + + Mazari FAK, Sharma N, Dodwell D, Horgan K (2018) Human Epidermal Growth Factor 2-positive breast cancer with mammographic microcalcification: relationship to pathologic complete response after neoadjuvant chemotherapy. Radiology 288(2):366–374 + + 29786482 + 10.1148/radiol.2018170960 + + + + Niikura N, Tomotaki A, Miyata H, Iwamoto T, Kawai M, Anan K et al (2016) Changes in tumor expression of HER2 and hormone receptors status after neoadjuvant chemotherapy in 21,755 patients from the Japanese breast cancer registry. Ann Oncol 27(3):480–487 + + 26704052 + 10.1093/annonc/mdv611 + + + + O’Grady S, Morgan MP (2018) Microcalcifications in breast cancer: from pathophysiology to diagnosis and prognosis. 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Acta Oncol 46(8):1178–1183 + + 17851833 + 10.1080/02841860701373611 + + + + Perez-Lopez R, Nava Rodrigues D, Figueiredo I, Mateo J, Collins DJ, Koh DM et al (2018) Multiparametric magnetic resonance imaging of prostate cancer bone disease: correlation with bone biopsy histological and molecular features. Invest Radiol 53(2):96–102 + + 28906339 + 5768227 + 10.1097/RLI.0000000000000415 + + + + Scimeca M, Giannini E, Antonacci C, Pistolese CA, Spagnoli LG, Bonanno E (2014) Microcalcifications in breast cancer: an active phenomenon mediated by epithelial cells with mesenchymal characteristics. BMC Cancer 14:286 + + 24758513 + 4021315 + 10.1186/1471-2407-14-286 + + + + Scott R, Stone N, Kendall C, Geraki K, Rogers K (2016) Relationships between pathology and crystal structure in breast calcifications: an in situ X-ray diffraction study in histological sections. NPJ Breast Cancer 2:16029 + + 28721386 + 5515336 + 10.1038/npjbcancer.2016.29 + + + + Sickles E, d’Orsi C, Bassett L, Appleton C, Berg W, (2013) Burnside EJAB-Ra, breast imaging reporting, et al. Acr bi-rads® mammography. 5 + + + Siegel RL, Miller KD, Fuchs HE, Jemal A (2022) Cancer statistics, 2022. CA Cancer J Clin 72(1):7–33 + + 35020204 + 10.3322/caac.21708 + + + + Spring L, Greenup R, Niemierko A, Schapira L, Haddad S, Jimenez R et al (2017) Pathologic complete response after neoadjuvant chemotherapy and long-term outcomes among young women with breast cancer. J Natl Compr Canc Netw 15(10):1216–1223 + + 28982747 + 10.6004/jnccn.2017.0158 + + + + Steenbruggen TG, van Ramshorst MS, Kok M, Linn SC, Smorenburg CH, Sonke GS (2017) Neoadjuvant therapy for breast cancer: established concepts and emerging strategies. 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Eur Radiol 31(3):1718–1726 + + 32939619 + 10.1007/s00330-020-07265-y + + + + Thompson BM, Chala LF, Shimizu C, Mano MS, Filassi JR, Geyer FC et al (2022) Pre-treatment MRI tumor features and post-treatment mammographic findings: may they contribute to refining the prediction of pathologic complete response in post-neoadjuvant breast cancer patients with radiologic complete response on MRI? Eur Radiol 32(3):1663–1675 + + 34716780 + 10.1007/s00330-021-08290-1 + + + + Toss A, Palazzo J, Berger A, Guiles F, Sendecki JA, Simone N et al (2016) Clinical-pathological features and treatment modalities associated with recurrence in DCIS and micro-invasive carcinoma: who to treat more and who to treat less. Breast 29:223–230 + + 27506636 + 10.1016/j.breast.2016.07.023 + + + + Tot T (2015) Early (<10 mm) HER2-positive invasive breast carcinomas are associated with extensive diffuse high-grade DCIS: implications for preoperative mapping, extent of surgical intervention, and disease-free survival. Ann Surg Oncol 22(8):2532–2539 + + 25582746 + 10.1245/s10434-015-4367-9 + + + + Tsau HS, Yen AM, Fann JC, Wu WY, Yu CP, Chen SL et al (2015) Mammographic tumour appearance and triple-negative breast cancer associated with long-term prognosis of breast cancer death: a Swedish Cohort Study. Cancer Epidemiol 39(2):200–208 + + 25731718 + 10.1016/j.canep.2015.01.013 + + + + von Minckwitz G, Untch M, Blohmer JU, Costa SD, Eidtmann H, Fasching PA et al (2012) Definition and impact of pathologic complete response on prognosis after neoadjuvant chemotherapy in various intrinsic breast cancer subtypes. J Clin Oncol 30(15):1796–1804 + + 10.1200/JCO.2011.38.8595 + + + + Wang N, Reeves KJ, Brown HK, Fowles AC, Docherty FE, Ottewell PD et al (2015) The frequency of osteolytic bone metastasis is determined by conditions of the soil, not the number of seeds; evidence from in vivo models of breast and prostate cancer. J Exp Clin Cancer Res 34:124 + + 26480944 + 4615337 + 10.1186/s13046-015-0240-8 + + + + Weigel S, Decker T, Korsching E, Hungermann D, Böcker W, Heindel W (2010) Calcifications in digital mammographic screening: improvement of early detection of invasive breast cancers? Radiology 255(3):738–745 + + 20501713 + 10.1148/radiol.10091173 + + + + Weiss A, Lee KC, Romero Y, Ward E, Kim Y, Ojeda-Fournier H et al (2014) Calcifications on mammogram do not correlate with tumor size after neoadjuvant chemotherapy. Ann Surg Oncol 21(10):3310–3316 + + 25056851 + 10.1245/s10434-014-3914-0 + + + + Whitworth P, Beitsch P, Mislowsky A, Pellicane JV, Nash C, Murray M et al (2017) Chemosensitivity and endocrine sensitivity in clinical luminal breast cancer patients in the prospective neoadjuvant breast registry symphony trial (NBRST) predicted by molecular subtyping. Ann Surg Oncol 24(3):669–675 + + 27770345 + 10.1245/s10434-016-5600-x + + + + Wolff AC, Hammond ME, Hicks DG, Dowsett M, McShane LM, Allison KH et al (2013) Recommendations for human epidermal growth factor receptor 2 testing in breast cancer: American society of clinical oncology/college of American Pathologists clinical practice guideline update. J Clin Oncol 31(31):3997–4013 + + 24101045 + 10.1200/JCO.2013.50.9984 + + + + +
+ + + 36917183 + + 2023 + 03 + 14 + +
+ + 1089-4098 + + 29 + 2 + + 2023 + Apr + + + The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry + Neuroscientist + + The Neuroscientist Comments. + + 146-147 + + 10.1177/10738584231157279 + eng + + Journal Article + +
+ + United States + Neuroscientist + 9504819 + 1073-8584 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + ppublish + + 36917183 + 10.1177/10738584231157279 + + +
+ + + 36917184 + + 2023 + 03 + 14 + +
+ + 1089-4098 + + 29 + 2 + + 2023 + Apr + + + The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry + Neuroscientist + + Forthcoming Articles. + + 144-145 + + 10.1177/10738584231157510 + eng + + Journal Article + +
+ + United States + Neuroscientist + 9504819 + 1073-8584 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + ppublish + + 36917184 + 10.1177/10738584231157510 + + +
+ + + 36917175 + + 2023 + 03 + 14 + +
+ + 1948-7185 + + + 2023 + Mar + 14 + + + The journal of physical chemistry letters + J Phys Chem Lett + + Identification of Ge≡O Triple Bond in Ge6O- Cluster: Anion Photoelectron Spectroscopy and Theoretical Calculations. + + 2854-2861 + + 10.1021/acs.jpclett.3c00207 + + Unlike C≡O, which is common in coordination chemistry and organometallic chemistry, little is known about Si≡O or Ge≡O compounds. Here we report a Ge6O- cluster featuring a Ge≡O triple bond. The structural and chemical bonding properties of Ge6O-/0 are investigated using anion photoelectron spectroscopy and theoretical calculations. Two nearly degenerate isomers have been found for Ge6O-. The lowest-energy structure (6A) can be viewed as an O atom bonding with a tetragonal bipyramidal Ge6. The second one (6B) can be considered as an O atom interacting with a capped trigonal bipyramidal Ge6. Chemical bonding analyses reveal that Ge6O- (6A) can be viewed as a Ge≡O unit interacting with a σ antiaromatic C2v symmetric tetragonal pyramidal Ge53- moiety. Comparisons of the chemical bonding in Ge6O- (6A) with that in Ge5CO- and Ge5MnO- indicate the similar behavior of Ge≡O to C≡O and Mn≡O in its bonding to the Ge53- and Ge54- moieties. + + + + Zhao + Li-Juan + LJ + 0000-0001-9346-2404 + + Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Molecular Reaction Dynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. + + + University of Chinese Academy of Sciences, Beijing 100049, China. + + + + Xu + Hong-Guang + HG + + Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Molecular Reaction Dynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. + + + University of Chinese Academy of Sciences, Beijing 100049, China. + + + + Xu + Xi-Ling + XL + + Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Molecular Reaction Dynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. + + + University of Chinese Academy of Sciences, Beijing 100049, China. + + + + Zheng + Wei-Jun + WJ + 0000-0002-9136-2693 + + Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Molecular Reaction Dynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. + + + University of Chinese Academy of Sciences, Beijing 100049, China. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + J Phys Chem Lett + 101526034 + 1948-7185 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 2 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917175 + 10.1021/acs.jpclett.3c00207 + + +
+ + + 36917186 + + 2023 + 03 + 14 + +
+ + 1549-9626 + + + 2023 + Mar + 14 + + + Journal of chemical theory and computation + J Chem Theory Comput + + Memory-Efficient Recursive Evaluation of 3-Center Gaussian Integrals. + 10.1021/acs.jctc.2c00995 + + To improve the efficiency of Gaussian integral evaluation on modern accelerated architectures, FLOP-efficient Obara-Saika-based recursive evaluation schemes are optimized for the memory footprint. For the 3-center 2-particle integrals that are key for the evaluation of Coulomb and other 2-particle interactions in the density-fitting approximation, the use of multiquantal recurrences (in which multiple quanta are created or transferred at once) is shown to produce significant memory savings. Other innovations include leveraging register memory for reduced memory footprint and direct compile-time generation of optimized kernels (instead of custom code generation) with compile-time features of modern C++/CUDA. Performance of conventional and CUDA-based implementations of the proposed schemes is illustrated for both the individual batches of integrals involving up to Gaussians with low and high angular momenta (up to L = 6) and contraction degrees, as well as for the density-fitting-based evaluation of the Coulomb potential. The computer implementation is available in the open-source LibintX library. + + + + Asadchev + Andrey + A + + Department of Chemistry, Virginia Tech, Blacksburg, Virginia 24061, United States. + + + + Valeev + Edward F + EF + 0000-0001-9923-6256 + + Department of Chemistry, Virginia Tech, Blacksburg, Virginia 24061, United States. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + J Chem Theory Comput + 101232704 + 1549-9618 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917186 + 10.1021/acs.jctc.2c00995 + + +
+ + + 36917179 + + 2023 + 03 + 14 + +
+ + 2379-3708 + + + 2023 + Mar + 14 + + + JCI insight + JCI Insight + + The crucial role of muscle glucocorticoid signaling in accelerating obesity and glucose intolerance via hyperinsulinemia. + 10.1172/jci.insight.162382 + e162382 + + Metabolic crosstalk from skeletal muscle to multiple organs is important for maintaining homeostasis, and its dysregulation can lead to various diseases. Chronic glucocorticoid administration often induces muscle atrophy and metabolic disorders such as diabetes and central obesity; however, the detailed underlying mechanism remains unclear. We previously reported that the deletion of glucocorticoid receptor (GR) in skeletal muscle increases muscle mass and reduces fat mass through muscle-liver-fat communication under physiological conditions. In this study, we show that muscle GR signaling plays a crucial role in accelerating obesity through the induction of hyperinsulinemia. Fat accumulation in liver and adipose tissue, muscle atrophy, hyperglycemia, and hyperinsulinemia induced by chronic corticosterone (CORT) treatment improved in muscle-specific GR knockout (GRmKO) mice. Such CORT-induced fat accumulation was alleviated by suppressing insulin production (streptozotocin injection), indicating that hyperinsulinemia enhanced by muscle GR signaling promotes obesity. Strikingly, glucose intolerance and obesity in ob/ob mice without CORT treatment were also improved in GRmKO mice, indicating that muscle GR signaling contributes to obesity-related metabolic changes, regardless of systemic glucocorticoid levels. Thus, this study provides new insight for the treatment of obesity and diabetes by targeting muscle GR signaling. + + + + Yamazaki + Hiroki + H + + Department of Biochemistry, Keio University School of Medicine, Tokyo, Japan. + + + + Uehara + Masaaki + M + + Department of Rheumatology and Allergy, IMSUT Hospital, Institute of Medical Science, The University of Tokyo, Tokyo, Japan. + + + + Yoshikawa + Noritada + N + + Center for Arthritis and Rheumatic Diseases, Kawasaki Municipal Hospital, Kawasaki-shi, Kanagawa, Japan. + + + + Kuribara-Souta + Akiko + A + + Department of Cell Processing and Transfusion, IMSUT Hospital, Institute of Medical Science, The University of Tokyo, Tokyo, Japan. + + + + Yamamoto + Motohisa + M + + Department of Rheumatology and Allergy, IMSUT Hospital, Institute of Medical Science, The University of Tokyo, Tokyo, Japan. + + + + Hirakawa + Yasuko + Y + + Department of Biochemistry, Keio University School of Medicine, Tokyo, Japan. + + + + Kabe + Yasuaki + Y + + Department of Biochemistry, Keio University School of Medicine, Tokyo, Japan. + + + + Suematsu + Makoto + M + + Department of Biochemistry, Keio University School of Medicine, Tokyo, Japan. + + + + Tanaka + Hirotoshi + H + + Department of Biochemistry, Keio University School of Medicine, Tokyo, Japan. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + JCI Insight + 101676073 + 2379-3708 + + IM + + Endocrinology + Insulin + Muscle Biology + Obesity + +
+ + + + 2023 + 3 + 14 + 12 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917179 + 162382 + 10.1172/jci.insight.162382 + + +
+ + + 36917177 + + 2023 + 03 + 14 + +
+ + 1558-8238 + + + 2023 + Mar + 14 + + + The Journal of clinical investigation + J Clin Invest + + Human IAPP is a contributor to painful diabetic peripheral neuropathy. + 10.1172/JCI156993 + e156993 + + Peripheral neuropathy is a frequent complication of type 2 diabetes mellitus (T2DM). We investigated whether human islet amyloid polypeptide (hIAPP), which forms pathogenic aggregates that damage pancreatic islet β-cells in T2DM, is involved in T2DM-associated peripheral neuropathy. In vitro, hIAPP incubation with sensory neurons reduced neurite outgrowth and increased levels of mitochondrial reactive oxygen species. Transgenic hIAPP mice that have elevated plasma hIAPP levels without hyperglycemia developed peripheral neuropathy as evidenced by pain-associated behavior and reduced intra-epidermal nerve fiber (IENF) density. Similarly, hIAPP Ob/Ob mice that have hyperglycaemia in combination with elevated plasma hIAPP levels had signs of neuropathy, although more aggravated.In wild-type mice, intraplantar and intravenous hIAPP injections induced long-lasting allodynia and decreased IENF density. Non-aggregating murine IAPP, mutated hIAPP (Pramlintide), or hIAPP with pharmacologically inhibited aggregation did not induce these effects. T2DM patients had reduced IENF density and more hIAPP oligomers in the skin compared to non-T2DM controls. Thus, we provide evidence that hIAPP aggregation is neurotoxic and mediates peripheral neuropathy in mice. The increased abundance of hIAPP aggregates in the skin of T2DM patients supports the notion that hIAPP is a potential contributor to T2DM neuropathy in humans. + + + + Albariqi + Mohammed Mh + MM + + Center for Translation Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands. + + + + Versteeg + Sabine + S + + Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands. + + + + Brakkee + Elisabeth M + EM + + Department of Plastic and Reconstructive Surgery, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands. + + + + Coert + J Henk + JH + + Department of Plastic and Reconstructive Surgery, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands. + + + + Elenbaas + Barend Ow + BO + + Bijvoet Centre for Biomolecular Research, Utrecht University, Utrecht, Netherlands. + + + + Prado + Judith + J + + Center for Translation Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands. + + + + Hack + C Erik + CE + + Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands. + + + + Höppener + Jo Wm + JW + + Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands. + + + + Eijkelkamp + Niels + N + + Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + J Clin Invest + 7802877 + 0021-9738 + + IM + + Diabetes + Immunology + Neuroscience + Pain + Protein misfolding + +
+ + + + 2023 + 3 + 14 + 12 + 2 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917177 + 156993 + 10.1172/JCI156993 + + +
+ + + 36917178 + + 2023 + 03 + 14 + +
+ + 2379-3708 + + + 2023 + Mar + 14 + + + JCI insight + JCI Insight + + Nucleolin promotes angiogenesis and endothelial metabolism along the onco-fetal axis in the human brain vasculature. + 10.1172/jci.insight.143071 + e143071 + + Glioblastoma is amongst the deadliest human cancers and is highly vascularized. Angiogenesis is very dynamic during brain development, almost quiescent in the adult brain but reactivated in vascular-dependent CNS pathologies including brain tumors. The onco-fetal axis describes the reactivation of fetal programs in tumors, but its relevance in endothelial- and perivascular cells of the human brain vasculature in glial brain tumors is unexplored. Nucleolin is a regulator of cell proliferation and angiogenesis, but its roles in the brain vasculature remain unknown. Here, we studied the expression of Nucleolin in the neurovascular unit in human fetal brains, adult brains and human gliomas in vivo and its effects on sprouting angiogenesis and endothelial metabolism in vitro. Nucleolin is highly expressed in endothelial- and perivascular cells during brain development, downregulated in the adult brain, and upregulated in glioma. Moreover, Nucleolin expression correlated with glioma malignancy in vivo. In culture, siRNA-mediated Nucleolin knock-down reduced human brain endothelial cell (HCMEC) and human umbilical vein endothelial cell (HUVEC) sprouting angiogenesis, proliferation, filopodia extension, and glucose metabolism. Furthermore, inhibition of Nucleolin with the aptamer AS1411 decreased brain endothelial cell proliferation in vitro. Mechanistically, Nucleolin knock-down in HCMECs and HUVECs uncovered regulation of angiogenesis involving VEGFR2 and of endothelial glycolysis. These findings identify Nucleolin as a neurodevelopmental factor reactivated in glioma that promotes sprouting angiogenesis and endothelial metabolism, characterizing Nucleolin as an onco-fetal protein. Our findings have potential implications in the therapeutic targeting of glioma. + + + + Schwab + Marc + M + + Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland. + + + + de Trizio + Ignazio + I + + Department of Basic Medical Sciences, University of Bari, Bari, Italy. + + + + Ghobrial + Moheb + M + + Department of Health Sciences and Technology, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland. + + + + Shiu + Jau-Ye + JY + + Department of Health Sciences and Technology, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland. + + + + Sürücü + Oguzkan + O + + Klinik für Psychiatrie und Psychotherapie, Center for Psychiatry Emmendingen, Emmendingen, Switzerland. + + + + Girolamo + Francesco + F + + Department of Basic Medical Sciences, University of Bari, Bari, Italy. + + + + Errede + Mariella + M + + Department of Basic Medical Sciences, University of Bari, Bari, Italy. + + + + Yilmaz + Murat + M + + Department of Internal Medicine, Cantonal Hospital Lucerne, Lucerne, Switzerland. + + + + Haybaeck + Johannes + J + + Institut of Pathology, Medical University Graz, Graz, Austria. + + + + Moiraghi + Alessandro + A + + Department of Clinical Neurosciences, University Hosptial Geneva, Geneva, Switzerland. + + + + Monnier + Philippe P + PP + + Genetics and Development, Toronto Western Research Institute, Toronto, Canada. + + + + Lawler + Sean E + SE + + Department of Neurosurgery, Brigham and Women's Hospital, Boston, United States of America. + + + + Greenfield + Jeffrey P + JP + + Department of Neurological Surgery, Weill Cornell Medical College, New York, United States of America. + + + + Radovanovic + Ivan + I + + Surgery, University of Toronto, Toronto, Canada. + + + + Frei + Karl + K + + Department of Neurosurgery, University Hospital Zürich, Zurich, Switzerland. + + + + Schlapbach + Ralph + R + + Functional Genomics Center Zurich, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland. + + + + Vogel + Viola + V + + Department of Health Sciences and Technology, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland. + + + + Virgintino + Daniela + D + + Department of Basic Medical Sciences, University of Bari, Bari, Italy. + + + + De Bock + Katrien + K + + Laboratory of Exercise and Health, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland. + + + + Wälchli + Thomas + T + + University of Toronto, Toronto, Canada. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + JCI Insight + 101676073 + 2379-3708 + + IM + + Angiogenesis + Brain cancer + Glucose metabolism + Neurodevelopment + Neuroscience + +
+ + + + 2023 + 3 + 14 + 12 + 2 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917178 + 143071 + 10.1172/jci.insight.143071 + + +
+ + + 36917185 + + 2023 + 03 + 14 + +
+ + 1089-4098 + + 29 + 2 + + 2023 + Apr + + + The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry + Neuroscientist + + The Neuroscientist Comments. + + 148 + + 10.1177/10738584231157278 + eng + + Journal Article + +
+ + United States + Neuroscientist + 9504819 + 1073-8584 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + ppublish + + 36917185 + 10.1177/10738584231157278 + + +
+ + + 36917180 + + 2023 + 03 + 14 + +
+ + 2379-3708 + + + 2023 + Mar + 14 + + + JCI insight + JCI Insight + + Tubular cell senescence promotes maladaptive kidney repair and chronic kidney disease after cisplatin nephrotoxicity. + 10.1172/jci.insight.166643 + e166643 + + Cisplatin is a widely used chemotherapy drug but it induces both acute and chronic kidney diseases (CKD) in cancer patients. The pathogenesis of cisplatin-induced CKD is unclear and effective renoprotective approaches are not available. Here, we report that repeated low-dose cisplatin (RLDC) treatment of C57BL/6 mice induced chronic cellular senescence in kidney tubules, accompanied with tubular degeneration and pro-fibrotic phenotype transformation that culminated in maladaptive repair and renal fibrosis. Suppression of tubular senescence by senolytic drugs ABT-263 and Fisetin attenuated renal fibrosis and improved tubular repair as indicated by restoration of tubular regeneration and renal function. In vitro, RLDC also induced senescence in mouse proximal tubular BUMPT cells. ABT-263 eliminated senescent BUMPT cells following RLDC treatment, reversed the pro-fibrotic phenotype of the cells and increased their clonogenic activity. Moreover, ABT-263 alleviated the paracrine effect of RLDC-treated BUMPT cells on fibroblasts for fibrosis. Consistently, knockdown of p16 suppressed post-RLDC senescence and fibrotic changes in BUMPT cells, and alleviated their paracrine effects on renal fibroblast proliferation. These results indicate that persistent induction of tubular senescence plays an important role in promoting cisplatin-induced CKD. Targeting senescent tubular cells may be efficient to improve kidney repair for the prevention and treatment of cisplatin-induced CKD. + + + + Li + Siyao + S + + Department of Nephrology, The Second Xiangya Hospital at Central South University, Changsha, China. + + + + Livingston + Man J + MJ + + Department of Cellular Biology and Anatomy, Augusta University, Augusta, United States of America. + + + + Ma + Zhengwei + Z + + Department of Cellular Biology and Anatomy, Augusta University, Augusta, United States of America. + + + + Hu + Xiaoru + X + + Department of Nephrology, The Second Xiangya Hospital at Central South University, Changsha, China. + + + + Wen + Lu + L + + Department of Nephrology, The Second Xiangya Hospital at Central South University, Changsha, China. + + + + Ding + Han-Fei + HF + + Department of Pathology, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, United States of America. + + + + Zhou + Daohong + D + + Department of Biochemistry & Structural Biology, University of Texas Health Science Center, San Antonio, United States of America. + + + + Dong + Zheng + Z + + Department of Nephrology, The Second Xiangya Hospital at Central South University, Changsha, China. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + JCI Insight + 101676073 + 2379-3708 + + IM + + Cellular senescence + Chronic kidney disease + Nephrology + +
+ + + + 2023 + 3 + 14 + 12 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917180 + 166643 + 10.1172/jci.insight.166643 + + +
+ + + 36917187 + + 2023 + 03 + 14 + +
+ + 1531-698X + + + 2023 + Mar + 15 + + + Current opinion in pediatrics + Curr Opin Pediatr + + Climate change, air pollution, pollen allergy and extreme atmospheric events. + 10.1097/MOP.0000000000001237 + + Respiratory allergy correlates strictly with air pollution and climate change. Due to climate change, the atmospheric content of trigger factors such as pollens and moulds increase and induce rhinitis and asthma in sensitized patients with IgE-mediated allergic reactions.Pollen allergy is frequently used to evaluate the relationship between air pollution and allergic respiratory diseases. Pollen allergens trigger the release of immunomodulatory and pro-inflammatory mediators and accelerate the onset of sensitization to respiratory allergens in predisposed children and adults. Lightning storms during pollen seasons can exacerbate respiratory allergy and asthma not only in adults but also in children with pollinosis. In this study, we have focalized the trigger (chemical and biologic) factors of outdoor air pollution. + Environmental pollution and climate change have harmful effects on human health, particularly on respiratory system, with frequent impact on social systems.Climate change is characterized by physic meteorological events inducing increase of production and emission of anthropogenic carbon dioxide (CO2) into the atmosphere. Allergenic plants produce more pollen as a response to high atmospheric levels of CO2. Climate change also affects extreme atmospheric events such as heat waves, droughts, thunderstorms, floods, cyclones and hurricanes. These climate events, in particular thunderstorms during pollen seasons, can increase the intensity of asthma attacks in pollinosis patients. + Climate change has important effects on the start and pathogenetic aspects of hypersensitivity of pollen allergy. Climate change causes an increase in the production of pollen and a change in the aspects increasing their allergenic properties. Through the effects of climate change, plant growth can be altered so that the new pollen produced are modified affecting more the human health. The need for public education and adoption of governmental measures to prevent environmental pollution and climate change are urgent. Efforts to reduce greenhouse gases, chemical and biologic contributors to air pollution are of critical importance. Extreme weather phenomena such as thunderstorms can trigger exacerbations of asthma attacks and need to be prevented with a correct information and therapy. + Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved. + + + + D'Amato + Gennaro + G + + Division of Respiratory and Allergic Diseases, Department of Chest Diseases, High Specialty A. Cardarelli Hospital, Napoli, Italy and Medical School of Specialization in Respiratory Diseases, University of Naples Federico II. + + + + D'Amato + Maria + M + + First Division of Pneumology, High Specialty Hospital 'V. Monaldi' and University 'Federico II' Medical School Naples, Napoli, Italy. + + + + eng + + Journal Article + + + 2023 + 03 + 15 + +
+ + United States + Curr Opin Pediatr + 9000850 + 1040-8703 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917187 + 10.1097/MOP.0000000000001237 + 00008480-990000000-00080 + + + + D’Amato G, Akdis C. Global warming, climate change, air pollution and allergies. Editorial. Allergy 2020; 75:2158–2160. + + + D’Amato G, Pawankar R, Vitale C, et al. Climate change and air pollution: effects on respiratory allergy. Allergy Asthma Immunol Res 2016; 8:391–395. + + + D’Amato G, Vitale C, Lanza M, et al. Climate change, air pollution, and allergic respiratory diseases: an update. Curr Opin Allergy Clin Immunol 2016; 16:434–440. + + + Hegerl GC, Zwiers FW, Braconnot P, et al., editors. Climate change 2007: the physical science basis. Contribution of the Working Group I to the Fourth Assessment Report of the Intergovernmental Panel on Climate Change. Cambridge, UK and New York: Cambridge University Press; 2007. pp. 663--746. + + + Bielory L, Lyons K, Goldberg R. Climate change and allergic disease. Curr Allergy Asthma Rep 2012; 12:485–494. + + + Silverberg JI, Braunstein M, Lee-Wong M. Association between climate factors, pollen counts and childhood hay fever prevalence in United States. J Allergy Clin Immunol 2015; 135:463–469. + + + Gent JF, Triche EW, Holford TR, et al. Association of low-level ozone and fine particles with respiratory symptoms in children with asthma. JAMA 2003; 290:1859–1867. + + + Rogers HH, Runion GB, Krupa SV. Plant responses to atmospheric CO2 enrichment with emphasis on roots and the rhizosphere. Environ Pollut 1994; 83:155–189. + + + Lindsey R. Climate change: atmospheric carbon dioxide. Climate Gov. [Accessed 17 August 2019]. + + + Wayne P, Foster S, Connolly J, et al. Production of allergenic pollen by ragweed (Ambrosia artemisiifolia L.) is increased in CO2-enriched atmospheres. Ann Allergy Asthma Immunol 2002; 88:279–282. + + + Cecchi L, D’Amato G, Annesi-Maesano I. External exposome and allergic respiratory and skin diseases. J Allergy Clin Immunol 2018; 141:846–857. + + + D’Amato G, Cecchi L, Bonini S, et al. Allergenic pollen and pollen allergy in Europe. Allergy 2007; 62:976–990. + + + Ziska LH, Bunce JA, Goins EW. Characterization of an urban-rural CO2/temperature gradient and associated changes in initial plant productivity during secondary succession. Oecologia 2004; 139:454–458. + + + Cecchi L, Morabito M, Domeneghetti MP, et al. Long distance transport of ragweed pollen as a potential cause of allergy in central Italy. Ann Allergy Asthma Immunol 2006; 96:86–91. + + + D’Amato G, Holgate ST, Pawankar R, et al. Meteorological conditions, climate change, new emerging factors, and asthma and related allergic disorders. A statement of the World Allergy Organization. World Allergy Organ J 2015; 8:25. + + + Davies JM. Grass pollen allergens globally: the contribution of subtropical grasses to burden of allergic respiratory diseases. Clin Exp Allergy 2014; 44:790–801. + + + Osborne NJ, Alcock I, Wheeler BW, et al. Pollen exposure and hospitalization due to asthma exacerbations: daily time series in a European city. Int J Biometeorol 2017; 61:1837–1848. + + + Biganzoli F, Zuloaga F. Analysis of Poaceae biodiversity in austral South America. Rodriguésia 2015; 66:337–351. + + + Soreng RJ, Peterson PM, Romaschenko K, et al. A worldwide phylogenetic classification of the Poaceae (Gramineae). J Syst Evol 2015; 53:117–137. + + + Soreng RJ, Peterson PM, Romaschenko K, et al. A worldwide phylogenetic classification of the Poaceae (Gramineae) II: an update and a comparison of two 2015 classifications. J Syst Evol 2017; 55:259–290. + + + Davies J, Timbrell V, Reibelt L, et al. Regional variation in allergic sensitivity to subtropical and temperate grass pollen allergens; outcomes of the multicenter cross-sectional Grass Pollen Allergy Survey (GPAS). Eur J Immunol 2016; 46:841. + + + Rogers CA, Wayne PM, Macklin EA, et al. Interaction of the onset of spring and elevated atmospheric CO2 on Ragweed (Ambrosia artemisiifolia L.) pollen production. Environ Health Perspect 2006; 114:865–869. + + + Albertine JM, Manning WJ, DaCosta M, et al. A. Projected carbon dioxide to increase grass pollen and allergen exposure despite higher ozone levels. PLoS One 2014; 9:e111712. + + + Sorokin Y, Zelikova TJ, Blumenthal D, et al. Seasonally contrasting responses of evapotranspiration to warming and elevated CO2 in a semiarid grassland. Ecohydrology 2017; 10:e1880. + + + Augustine DJ, Derner JD, Milchunas D, et al. Grazing moderates increases in C3 grass abundance over seven decades across a soil texture gradient in shortgrass steppe. J Veget Sci 2017; 28:562–572. + + + Willer H, Julia L, editors. The World of Organic Agriculture. Statistics and Emerging Trends 2016. 17 editions. Research Institute of Organic Agriculture FiBL and IFOAM Organics International, Frick and Bonn. + + + D’Amato G, Cecchi L. Effects of climate change on environmental factors in respiratory allergic diseases. Clin Exp Allergy 2008; 38:1264–1274. + + + Islam T, Gauderman WJ, Berhane K, et al. Relationship between air pollution, lung function and asthma in adolescents. Thorax 2007; 62:957–963. + + + D’Amato G, Liccardi G, D’Amato M, Holgate S. Environmental risk factors and allergic bronchial asthma. Clin Exp Allergy 2005; 35:1113–1124. + + + D’Amato G, Annesi-Maesano I, Urrutia-Pereira M, et al. Thunderstorm allergy and asthma: state of the art. Multidiscip Respir Med 2021; 16:806–811. + + + D’Amato G, Cecchi L. Thunderstorm-related asthma, not only grass pollen and spores. J Allergy Clin Immunol 2008; 121:537–538. + + + D’Amato G, Vitale C, D’Amato M, et al. Thunderstorm-related asthma: what happens and why. Clin Exp Allergy 2016; 46:390–396. + + + D’Amato G, Cecchi L, Annesi-Maesano I. A trans-disciplinary overview of case reports of thunderstorm-related asthma outbreaks and relapse. Eur Respir Rev 2012; 21:82–87. + + + Andrew E, Nehme Z, Bernard S, et al. Stormy weather: a retrospective analysis of demand for emergency medical services during epidemic thunderstorm asthma. BMJ 2017; 359:j5636. + + + Lindstrom SJ, Silver JD, Sutherland MF. Thunderstorm asthma outbreak of November 2016: a natural disaster requiring planning. Med J Aust 2017; 207:235–237. + + + Final Report: literature review on thunderstorm asthma and its implications for public health advice. Queensland University of Technology. Brisbane, Australia. Contracted by: Department of Health and Human Services, Victorian State Government. 19 May 2017. + + + Xu YY, Xue T, Li HR, Guan K. Retrospective analysis of epidemic thunderstorm asthma in children in Yulin, northwest China. Pediatr Res 2021; 89:958–961. + + + Rossati A. Global warming and its health impact. Int J Occup Environ Med 2017; 8:7–20. + + + Woodward AJ, Samet JM. Climate change, hurricanes, and health. Am J Public Health 2018; 108:33–35. + + + Waddell SL, Jayaweera DT, Mirsaeidi M, et al. Perspectives on the health effects of hurricanes: a review and challenges. Int J Environ Res Public Health 2021; 18:2756. + + + Annesi-Maesano I, Maesano C N, D’Amato M, D’Amato G. Pros and cons for the role of air pollution on COVID-19 development. Allergy 2021; 76:2647–2649. + + + McMichael AJ, Woodruff RE, Hales S. Climate change and human health: present and future risks. Lancet 2006; 367:859–869. + + + +
+ + + 36917188 + + 2023 + 03 + 14 + +
+ + 1558-8238 + + + 2023 + Mar + 14 + + + The Journal of clinical investigation + J Clin Invest + + Monoclonal antibody Y01 prevents tauopathy progression induced by lysine280-acetylated tau in cell and mouse models. + 10.1172/JCI156537 + e156537 + + The spatiotemporal pattern of the spread of pathologically modified tau through brain regions in Alzheimer's disease (AD) can be explained by prion-like cell-to-cell seeding and propagation of misfolded tau aggregates. Hence, to develop targeted therapeutic antibodies, it is important to identify the seeding- and propagation-competent tau species. The hexapeptide 275VQIINK280 of tau is a critical region for tau aggregation, and K280 is acetylated in various tauopathies including AD. However, the mechanism that links tau acetylated on lysine 280 (tau-acK280) to subsequent progression to neurodegenerative disease remains unclear. Here, we demonstrate that tau-acK280 is critical for tau propagation processes including secretion, aggregation, and seeding. We developed an antibody, Y01, that specifically targets tau-acK280 and solved the crystal structure of Y01 in complex with an acK280 peptide. The structure confirmed that Y01 directly recognizes acK280 and the surrounding residues. Strikingly, upon interaction with acetylated tau aggregates, Y01 prevented tauopathy progression and increased neuronal viability in neuron cultures and in tau transgenic mice through antibody-mediated neutralization and phagocytosis, respectively. Based on our observations that tau-acK280 is a core species involved in seeding and propagation activities, the Y01 antibody that specifically recognizes acK280 represents a promising therapeutic candidate for AD and other neurodegenerative diseases associated with tauopathy. + + + + Song + Ha-Lim + HL + + ADEL Institute of Science & Technology (AIST), ADEL, Inc., Seoul, Korea, Republic of. + + + + Kim + Na-Young + NY + + ADEL Institute of Science & Technology (AIST), ADEL, Inc., Seoul, Korea, Republic of. + + + + Park + Jaewan + J + + Division of Biological Science and Technology, Yonsei University, Wonju, Korea, Republic of. + + + + Kim + Meong Il + MI + + Division of Biological Science and Technology, Yonsei University, Wonju, Korea, Republic of. + + + + Jeon + Yu-Na + YN + + Department of Brain Science, University of Ulsan College of Medicine, Seoul, Korea, Republic of. + + + + Lee + Se-Jong + SJ + + Department of Brain Science, University of Ulsan College of Medicine, Seoul, Korea, Republic of. + + + + Cho + Kwangmin + K + + ADEL Institute of Science & Technology (AIST), ADEL, Inc., Seoul, Korea, Republic of. + + + + Shim + Young-Lim + YL + + ADEL Institute of Science & Technology (AIST), ADEL, Inc., Seoul, Korea, Republic of. + + + + Lee + Kyoung-Hye + KH + + ADEL Institute of Science & Technology (AIST), ADEL, Inc., Seoul, Korea, Republic of. + + + + Mun + Yeon-Seon + YS + + ADEL Institute of Science & Technology (AIST), ADEL, Inc., Seoul, Korea, Republic of. + + + + Song + Jung-A + JA + + ADEL Institute of Science & Technology (AIST), ADEL, Inc., Seoul, Korea, Republic of. + + + + Kim + Min-Seok + MS + + ADEL Institute of Science & Technology (AIST), ADEL, Inc., Seoul, Korea, Republic of. + + + + Pack + Chan-Gi + CG + + Department of Convergence Medicine, University of Ulsan College of Medicine, Seoul, Korea, Republic of. + + + + Jung + Minkyo + M + + Neural Circuits Research Group, Korea Brain Research Institute, Daegu, Korea, Republic of. + + + + Jang + Hyemin + H + + Departments of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of. + + + + Na + Duk L + DL + + Departments of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of. + + + + Hong + Minsun + M + + Division of Biological Science and Technology, Yonsei University, Wonju, Korea, Republic of. + + + + Kim + Dong-Hou + DH + + Department of Brain Science, University of Ulsan College of Medicine, Seoul, Korea, Republic of. + + + + Yoon + Seung-Yong + SY + + Department of Brain Science, University of Ulsan College of Medicine, Seoul, Korea, Republic of. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + J Clin Invest + 7802877 + 0021-9738 + + IM + + Alzheimer disease + Immunotherapy + Neuroscience + Therapeutics + +
+ + + + 2023 + 3 + 14 + 12 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917188 + 156537 + 10.1172/JCI156537 + + +
+ + + 36917190 + + 2023 + 03 + 14 + +
+ + 2042-650X + + + 2023 + Mar + 14 + + + Food & function + Food Funct + + Vanillin and pentoxifylline ameliorate isoproterenol-induced myocardial injury in rats via the Akt/HIF-1α/VEGF signaling pathway. + 10.1039/d2fo03570g + + Myocardial infarction (MI) is a major health problem associated with high morbidity and mortality. Recently, angiogenesis has emerged as a novel therapeutic approach against ischemic diseases including MI. Therefore, we aimed to investigate the potential angiogenic effects of vanillin (Van) both alone and in combination with pentoxifylline (PTX), and to examine the molecular mechanisms through which Van and PTX may ameliorate cardiac injury induced in rats including their effects on oxidative stress, inflammation and apoptosis which play a key role in MI pathogenesis. MI was induced in rats using isoproterenol (ISO) (150 mg kg-1, SC, twice at a 24 h interval). Then, rats were treated orally with Van (150 mg kg-1 day-1), PTX (50 mg kg-1 day-1) or Van + PTX combination. ISO-induced cardiac injury was characterized by cardiac hypertrophy, ST-segment elevation and elevated serum levels of troponin-I, creatine kinase-MB and lactate dehydrogenase. Cardiac levels of the antioxidant markers GSH and SOD and the antiapoptotic protein Bcl-2 were decreased. On the other hand, cardiac levels of the oxidative stress marker malonaldehyde, the inflammatory cytokines TNF-α, IL-6 and IL-1β, the proapoptotic protein Bax, and caspase-3 were increased. Moreover, the cardiac levels of p-Akt and HIF-1α and the mRNA expression levels of the angiogenic genes VEGF, FGF-2 and ANGPT-1 were increased. Treatment with either Van or PTX ameliorated ISO-induced changes and further upregulated Akt/HIF-1α/VEGF signaling. Furthermore, Van + PTX combination was more effective than monotherapy. These findings suggest a novel therapeutic potential of Van and PTX in ameliorating MI through enhancing cardiac angiogenesis and modulating oxidative stress, inflammation and apoptosis. + + + + Elseweidy + Mohamed M + MM + http://orcid.org/0000-0001-8167-7563 + + Department of Biochemistry, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt. mmElseweidy@pharmacy.zu.edu.eg. + + + + Ali + Sousou I + SI + + Department of Biochemistry, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt. mmElseweidy@pharmacy.zu.edu.eg. + + + + Shaheen + Mohamed A + MA + + Department of Histology and Cell Biology, Faculty of Human Medicine, Zagazig University, Zagazig, 44519, Egypt. + + + + Abdelghafour + Asmaa M + AM + http://orcid.org/0000-0003-3504-8162 + + Department of Biochemistry, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt. mmElseweidy@pharmacy.zu.edu.eg. + + + + Hammad + Sally K + SK + http://orcid.org/0000-0003-3887-4398 + + Department of Biochemistry, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt. mmElseweidy@pharmacy.zu.edu.eg. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + England + Food Funct + 101549033 + 2042-6496 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917190 + 10.1039/d2fo03570g + + +
+ + + 36917191 + + 2023 + 03 + 14 + +
+ + 1536-4844 + + + 2023 + Mar + 14 + + + Inflammatory bowel diseases + Inflamm Bowel Dis + + Residence in Peripheral Regions and Low Socioeconomic Status Are Associated With Worse Outcomes of Inflammatory Bowel Diseases: A Nationwide Study From the epi-IIRN. + izad034 + 10.1093/ibd/izad034 + + Timely access to quality medical care impacts patient outcomes in inflammatory bowel disease (IBD). In a nationwide study from the epidemiology group of the Israeli IBD research nucleus we aimed to assess the impact of residence and socioeconomic status (SES) on disease outcomes. + We utilized data from the 4 health maintenance organizations in Israel, representing 98% of the population. Regions were defined as central, northern and southern; SES was graded from lowest to highest (from 1 to 4) as per Israel Central Bureau of Statistics. The primary outcome was steroid dependency, with secondary outcomes of surgeries and biologic therapy use. + A total of 28 216 IBD patients were included: 15 818 (56%) Crohn's disease (CD) and 12 398 (44%) ulcerative colitis; 74%, 12% and 14% resided in central, southern, and northern Israel, respectively (SES 1: 21%, SES 4: 12%). Lower SES was associated with steroid dependency (20% in SES 1 vs 12% in SES 4 in CD; P < .001; and 18% vs 12% in ulcerative colitis; P < .001), and higher surgery rates (12% vs 7%; P < .001, and 1.4% vs 0.7%; P = .115, respectively). There were higher steroid dependency and CD surgery rates in peripheral vs central regions. In multivariable models, both SES and peripheral region were independently associated with poorer outcomes. + We found that lower SES and peripheral residence were associated with deleterious outcomes in IBD. This should be considered by policymakers and should encourage strategies for improving outcomes in populations at risk. + © The Author(s) 2023. Published by Oxford University Press on behalf of Crohn’s & Colitis Foundation. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. + + + + Ledder + Oren + O + 0000-0001-8109-814X + + Juliet Keidan Institute of Paediatric Gastroenterology and Nutrition, Shaare Zedek Medical Center, Jerusalem, Israel. + + + Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. + + + + Harel + Sasha + S + + Juliet Keidan Institute of Paediatric Gastroenterology and Nutrition, Shaare Zedek Medical Center, Jerusalem, Israel. + + + + Lujan + Rona + R + + Juliet Keidan Institute of Paediatric Gastroenterology and Nutrition, Shaare Zedek Medical Center, Jerusalem, Israel. + + + + Friss + Chagit + C + + Juliet Keidan Institute of Paediatric Gastroenterology and Nutrition, Shaare Zedek Medical Center, Jerusalem, Israel. + + + + Orlanski-Meyer + Esther + E + + Juliet Keidan Institute of Paediatric Gastroenterology and Nutrition, Shaare Zedek Medical Center, Jerusalem, Israel. + + + + Yogev + Dotan + D + 0000-0003-2431-0284 + + Juliet Keidan Institute of Paediatric Gastroenterology and Nutrition, Shaare Zedek Medical Center, Jerusalem, Israel. + + + + Loewenberg Weisband + Yiska + Y + + Clalit Research Institute, Chief's Office, Clalit Health Services, Tel Aviv, Israel. + + + + Greenfeld + Shira + S + + Maccabi Healthcare Services, Tel Aviv, Israel. + + + + Kariv + Revital + R + + Maccabi Healthcare Services, Tel Aviv, Israel. + + + + Lederman + Natan + N + + Meuhedet Health Services, Tel Aviv, Israel. + + + + Matz + Eran + E + + Leumit Health Services, Tel Aviv, Israel. + + + + Schwartz + Doron + D + + Department of Gastroenterology and Hepatology, Soroka Medical Center, Ben-Gurion University of the Negev, Beer Sheva, Israel. + + + + Focht + Gili + G + + Juliet Keidan Institute of Paediatric Gastroenterology and Nutrition, Shaare Zedek Medical Center, Jerusalem, Israel. + + + + Dotan + Iris + I + + Division of Gastroenterology, Rabin Medical Center, Petah Tikva, Israel. + + + Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. + + + + Turner + Dan + D + + Juliet Keidan Institute of Paediatric Gastroenterology and Nutrition, Shaare Zedek Medical Center, Jerusalem, Israel. + + + Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. + + + + eng + + + Leona M. and Harry B. Helmsley Charitable Trust + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + England + Inflamm Bowel Dis + 9508162 + 1078-0998 + + IM + + In a novel nationwide population study, we found that patients with inflammatory bowel disease living in peripheral regions and those with lower socioeconomic status had significantly worse inflammatory bowel disease outcomes, notably higher corticosteroid dependency, higher surgery rate, and higher repeat surgery rate. + + + inflammatory bowel disease + medical access + socioeconomic status + +
+ + + + 2022 + 08 + 29 + + + 2023 + 3 + 14 + 12 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917191 + 7077430 + 10.1093/ibd/izad034 + + +
+ + + 36917195 + + 2023 + 03 + 14 + +
+ + 2379-3708 + + + 2023 + Mar + 14 + + + JCI insight + JCI Insight + + Plasmin and plasminogen prevent sepsis severity by reducing neutrophil extracellular traps and systemic inflammation. + 10.1172/jci.insight.166044 + e166044 + + Sepsis is a lethal syndrome characterized by systemic inflammation and abnormal coagulation. Despite therapeutic advances, sepsis mortality remains substantially high. Herein, we investigated the role of the plasminogen/plasmin (Plg/Pla) system during sepsis. Plasma levels of Plg were significantly lower in mice subjected to severe compared with non-severe sepsis, whereas systemic levels of IL-6, a marker of sepsis severity, were higher in severe sepsis. Plg levels correlated negatively with IL-6 in both septic mice and patients while the plasminogen activator inhibitor-1 (PAI-1) correlated positively with IL-6. Plg deficiency render mice susceptible to non-severe sepsis induced by cecal ligation and puncture (CLP), showing higher numbers of neutrophils and M1 macrophages, liver fibrin(ogen) deposition, lower efferocytosis and increased IL-6 and neutrophil extracellular traps (NETs) release associated with organ damage. Conversely, inflammatory features, fibrin(ogen) and organ damage were substantially reduced, and efferocytosis was increased by exogenous Pla given during CLP and LPS-induced endotoxemia. Plg or Pla protected mice from sepsis-induced lethality and enhanced the protective effect of antibiotics. Mechanistically, Plg/Pla afforded protection was associated with regulation of NET release, requiring Pla-protease activity and lysine binding sites. Altogether, Plg/Pla are important host protective players during sepsis, controlling local and systemic inflammation and collateral organ damage. + + + + Vago + Juliana P + JP + + Departamento de Análises Clínicas e Toxicológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. + + + + Zaidan + Isabella + I + + Departamento de Análises Clínicas e Toxicológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. + + + + Perucci + Luiza O + LO + + Departamento de Ciências Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, Brazil. + + + + Brito + Larissa F + LF + + Departamento de Análises Clínicas e Toxicológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. + + + + Teixeira + Lívia Cr + LC + + Departamento de Análises Clínicas e Toxicológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. + + + + Silva + Camila Ms + CM + + Departamento de Farmacologia, Universidade de São Paulo, Ribeirao Preto, Brazil. + + + + Miranda + Thaís C + TC + + Departamento de Análises Clínicas e Toxicológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. + + + + Melo + Eliza M + EM + + Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. + + + + Bruno + Alexandre S + AS + + Departamento de Farmacologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. + + + + Queiroz-Junior + Celso M + CM + + Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. + + + + Sugimoto + Michelle A + MA + + Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. + + + + Tavares + Luciana P + LP + + Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. + + + + Grossi + Laís C + LC + + Departamento de Análises Clínicas e Toxicológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. + + + + Borges + Isabela N + IN + + Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. + + + + Baik + Nagyung + N + + Department of Molecular Medicine, The Scripps Research Institute, La Jolla, United States of America. + + + + Talvani + André + A + + Departamento de Ciências Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, Brazil. + + + + Ferreira + Raphael G + RG + + Departamento de Farmacologia, Universidade de São Paulo, Ribeirao Preto, Brazil. + + + + Alves-Filho + José C + JC + + Departamento de Farmacologia, Universidade de São Paulo, Ribeirao Preto, Brazil. + + + + Nobre + Vandack + V + + Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. + + + + Teixeira + Mauro M + MM + + Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. + + + + Parmer + Robert J + RJ + + Department of Medicine, UCSD, San Diego, United States of America. + + + + Miles + Lindsey A + LA + + Department of Molecular Medicine, The Scripps Research Institute, La Jolla, United States of America. + + + + Sousa + Lirlândia P + LP + + Departamento de Análises Clínicas e Toxicológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + JCI Insight + 101676073 + 2379-3708 + + IM + + Bacterial infections + Infectious disease + Plasmin + +
+ + + + 2023 + 3 + 14 + 12 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917195 + 166044 + 10.1172/jci.insight.166044 + + +
+ + + 36917192 + + 2023 + 03 + 14 + +
+ + 1477-9234 + + + 2023 + Mar + 14 + + + Dalton transactions (Cambridge, England : 2003) + Dalton Trans + + Electrocatalytic properties of a novel ruthenium(II) terpyridine-based complex towards CO2 reduction. + 10.1039/d3dt00121k + + The electrocatalytic properties of Ru complexes are of great technological interest given their potential application in reactions such water splitting and CO2 reduction. In this work, a novel terpyridine-based Ru(II) complex, [RuCl(trpy)(acpy)], trpy = 2,2':6',2''-terpyridine, acpy- = 2-pyridylacetate was synthesized and its spectroscopic, electrochemical and catalytic properties were explored in detail. In dry acetonitrile, the complex exhibits two reduction peaks at -1.95 V and -2.20 V vs. Fc/Fc+, attributed to consecutive 1 e- reduction. Under CO2 atmosphere, a catalytic wave is observed (Eonset = 2.1 V vs. Fc/Fc+), with CO as the main reduction product. Bulk electrolysis reveals a turnover number (TON) of 12 (kobs = 1.5 s-1). In the presence of 1% water, an improvement in the catalytic activity is observed (TONCO = 21 and kobs = 2.0 s-1) and, additionally, formate was also detected (TONHCOO = 7). Spectroelectrochemical experiments allowed the identification of a metallocarboxylate (Ru-COO-) intermediate under anhydrous conditions, while in water, the partial labilization of the acpy- ligand was observed in the course of the catalytic cycle. The experimental data was combined with DFT calculations, allowing the proposal of a catalytic cycle. The results establish important relationships between selectivity, ligand structure and reaction conditions. + + + + Faustino + Leandro A + LA + http://orcid.org/0000-0003-0116-2047 + + Laboratory of Photochemistry and Materials Science, Universidade Federal de Uberlândia - UFU, Av. João Naves de Ávila 212, 38400-902, Uberlândia, Minas Gerais, Brazil. otaviopatrocinio@ufu.br. + + + + Machado + Antonio E H + AEH + http://orcid.org/0000-0001-6200-3686 + + Laboratory of Photochemistry and Materials Science, Universidade Federal de Uberlândia - UFU, Av. João Naves de Ávila 212, 38400-902, Uberlândia, Minas Gerais, Brazil. otaviopatrocinio@ufu.br. + + + Programa de Doutorado em Ciências Exatas e Tecnológicas, Universidade Federal de Catalão - UFCat, Av. Dr. Lamartine Pinto de Avelar 1120, Catalão, Goiás, Brazil. + + + + Maia + Pedro I S + PIS + http://orcid.org/0000-0003-4699-9481 + + Núcleo de Desenvolvimento de Compostos Bioativos (NDCBio), Universidade Federal do Triângulo Mineiro, Av. Dr. Randolfo Borges 1400, 38025-440, Uberaba, Minas Gerais, Brazil. + + + + Concepcion + Javier J + JJ + http://orcid.org/0000-0002-9296-0943 + + Chemistry Division, Brookhaven National Laboratory, Upton, New York 11973-5000, USA. + + + + Patrocinio + Antonio Otavio T + AOT + http://orcid.org/0000-0003-3141-3214 + + Laboratory of Photochemistry and Materials Science, Universidade Federal de Uberlândia - UFU, Av. João Naves de Ávila 212, 38400-902, Uberlândia, Minas Gerais, Brazil. otaviopatrocinio@ufu.br. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + England + Dalton Trans + 101176026 + 1477-9226 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917192 + 10.1039/d3dt00121k + + +
+ + + 36917193 + + 2023 + 03 + 14 + +
+ + 1558-8238 + + + 2023 + Mar + 14 + + + The Journal of clinical investigation + J Clin Invest + + Elevated prelimbic cortex-to-basolateral amygdala circuit activity mediates comorbid anxiety-like behaviors in chronic pain. + 10.1172/JCI166356 + e166356 + + Chronic pain could cause both hyperalgesia and anxiety symptoms. How the two components are encoded in the brain remains unclear. The prelimbic cortex (PrL), a critical brain region for both nociceptive and emotional modulations, serves as an ideal medium for comparing the encoding of the two components. We report that PrL neurons projecting to the basolateral amygdala (PrLBLA) and those projecting to the ventrolateral periaqueductal gray (PrLl/vlPAG) were segregated and displayed elevated and reduced neuronal activity, respectively, during pain chronicity. Consistently, optogenetic suppression of PrL→BLA circuit reversed anxiety-like behaviors whereas activation of PrL→l/vlPAG circuit attenuated hyperalgesia in mice with chronic pain. Moreover, mechanistic studies indicated that elevated TNF-α/TNFR1 signaling in PrL caused increased insertion of GluA1 receptors into PrLBLA neurons contributing to anxiety-like behaviors in mice with chronic pain. Together, these results provide insights into the circuit and molecular mechanisms in PrL for controlling pain-related hyperalgesia and anxiety-like behaviors. + + + + Gao + Feng + F + + Department of Neurology, Guangzhou Medical University, Guangzhou, China. + + + + Huang + Jie + J + + Department of Neurology, Guangzhou Medical University, Guangzhou, China. + + + + Huang + Guo-Bin + GB + + Department of Neurology, Guangzhou Medical University, Guangzhou, China. + + + + You + Qiang-Long + QL + + Department of Neurology, Guangzhou Medical University, Guangzhou, China. + + + + Yao + Shan + S + + Department of Neurology, Guangzhou Medical University, Guangzhou, China. + + + + Zhao + Shen-Ting + ST + + Department of Physiology, Guangzhou Medical University, Guangzhou, China. + + + + Liu + Jian + J + + Department of Neurology, Guangzhou Medical University, Guangzhou, China. + + + + Wu + Cui-Hong + CH + + Department of Neurology, Guangzhou Medical University, Guangzhou, China. + + + + Chen + Gui-Fu + GF + + Department of Neurology, Guangzhou Medical University, Guangzhou, China. + + + + Liu + Shi-Min + SM + + Department of Neurology, Guangzhou Medical University, Guangzhou, China. + + + + Yu + Zongyan + Z + + Department of Neurology, Guangzhou Medical University, Guangzhou, China. + + + + Zhou + Yan-Ling + YL + + Department of Psychiatry, Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China. + + + + Ning + Yu-Ping + YP + + Department of Psychiatry, Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China. + + + + Liu + Shenquan + S + + School of Mathematics, South China University of Technology, Guangzhou, China. + + + + Hu + Bing-Jie + BJ + + Department of Neurology, Guangzhou Medical University, Guangzhou, China. + + + + Sun + Xiang-Dong + XD + + Department of Neurology, Guangzhou Medical University, Guangzhou, China. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + J Clin Invest + 7802877 + 0021-9738 + + IM + + Behavior + Cytokines + Neuroscience + Pain + +
+ + + + 2023 + 3 + 14 + 12 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917193 + 166356 + 10.1172/JCI166356 + + +
+ + + 36917197 + + 2023 + 03 + 14 + +
+ + 1097-0355 + + + 2023 + Mar + 14 + + + Infant mental health journal + Infant Ment Health J + + What works for whom? Mother's psychological distress as a moderator of the effectiveness of a home visiting intervention. + 10.1002/imhj.22050 + + Attachment-based home visiting programs that serve new mothers experiencing psychological distress may advance health equity by helping families systemically exposed to adversity. This study examined whether one such program (Promoting First Relationships/PFR) had particularly beneficial effects on maternal and child relationship outcomes for mothers reporting the greatest psychological distress. A randomized controlled trial of the PFR program included a low-income sample of 252 Spanish- and English-speaking mother-child dyads referred prenatally for mental health concerns. The sample of mothers was 65.5% White, 17.5% Black, and 17.1% multiracial or other racial groups; 47.2% reported Hispanic ethnicity. The moderating variable of psychological distress was measured using maternal-reported screening tools for symptoms of depression, anxiety, anger, post-traumatic stress, and interpersonal sensitivity. Outcomes included observed parenting sensitivity and self-reported understanding of infants/toddlers, caregiving confidence, and child externalizing behavior. Results showed a significant treatment condition by baseline psychological distress interaction for observed parenting sensitivity such that differences in outcomes favoring the PFR condition were greatest among those with high baseline psychological distress (baseline child age 6-12 weeks). In a low-income sample of new mothers, those with the greatest need, as indicated by high psychological distress, showed greater improvements in their sensitive and responsive caregiving if they were randomized to the PFR treatment condition. + © 2023 Michigan Association for Infant Mental Health. + + + + Oxford + Monica L + ML + https://orcid.org/0000-0002-0506-843X + + Child, Family, and Population Health Nursing at the University of Washington, Seattle, Washington, USA. + + + + Hash + Jonika B + JB + + Child, Family, and Population Health Nursing at the University of Washington, Seattle, Washington, USA. + + + + Lohr + Mary Jane + MJ + + Child, Family, and Population Health Nursing at the University of Washington, Seattle, Washington, USA. + + + + Fleming + Charles B + CB + + Department of Psychiatry and Behavioral Sciences at the University of Washington, Seattle, Washington, USA. + + + + Dow-Smith + Carrie + C + + WakeMed Children's Hospital, Pediatric Primary Care, Raleigh, North Carolina, USA. + + + + Spieker + Susan J + SJ + https://orcid.org/0000-0003-4768-0181 + + Child, Family, and Population Health Nursing at the University of Washington, Seattle, Washington, USA. + + + + eng + + + R01 HD052809 + HD + NICHD NIH HHS + United States + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Infant Ment Health J + 8007859 + 0163-9641 + + IM + + Promoting First Relationships + home visiting + perinatal depression + psychological distress + randomized control trial + +
+ + + + 2023 + 02 + 21 + + + 2021 + 08 + 23 + + + 2023 + 02 + 21 + + + 2023 + 3 + 14 + 12 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917197 + 10.1002/imhj.22050 + + + REFERENCES + + Badr, L. K. (2005). Further psychometric testing and use of the Maternal Confidence Questionnaire. Issues in Comprehensive Pediatric Nursing, 28(3), 163-174. https://doi.org/10.1080/01460860500227572 + + + Bakermans-Kranenburg, M. J., Van Ijzendoorn, M. H., & Juffer, F. (2003). Less is more: Meta-analyses of sensitivity and attachment interventions in early childhood. Psychological Bulletin, 129(2), 195. https://doi.org/10.1037/0033-2909.129.2.195 + + + Barnard, K. E. (1994). What the teaching scale measures. In G. S. Sumner & A. Spietz (Eds.), NCAST: Caregiver/parent-child interaction teaching manual. University of Washington NCAST Publications. + + + Beck, C. T. (1996). A meta-analysis of predictors of postpartum depression. Nursing Research, 45(5), 297-303. https://doi.org/10.1097/00006199-199609000-00008 + + + Beebe, B., Jaffe, J., Buck, K., Chen, H., Cohen, P., Feldstein, S., & Andrews, H. (2008). Six-week postpartum maternal depressive symptoms and 4-month mother-infant self- and interactive contingency. Infant Mental Health Journal, 29(5), 442-471. https://doi.org/10.1002/imhj.20191 + + + Berlin, L. J., Martoccio, T. L., & Jones Harden, B. (2018). Improving Early Head Start's impacts on parenting through attachment-based intervention: A randomized controlled trial. Developmental Psychology, 54(12), 2316. https://doi.org/10.1037/dev0000592 + + + Berlin, L. J., West, A., & Jones Harden, B. (2021). Attachment and early home visiting: Toward a more perfect union. In R. A. Thompson, J. A. Simpson, & L. J. Berlin (Eds.), Attachment: The fundamental questions (pp. 381-389). Guilford Press. + + + Berlin, L. J., Whiteside-Mansell, L., Roggman, L. A., Green, B. L., Robinson, J., & Spieker, S. (2011). Testing maternal depression and attachment style as moderators of Early Head Start's effects on parenting. Attachment & Human Development, 13(1), 49-67. https://doi.org/10.1080/14616734.2010.488122 + + + Bierman, K. L., Heinrichs, B. S., Welsh, J. A., & Nix, R. L. (2021). Sustained benefits of a preschool home visiting program: Child outcomes in fifth grade. Early Childhood Research Quarterly, 56, 260-271. https://doi.org/10.1016/j.ecresq.2021.03.017 + + + Bigelow, A. E., Beebe, B., Power, M., Stafford, A.-L., Ewing, J., Egleson, A., & Kaminer, T. (2018). Longitudinal relations among maternal depressive symptoms, maternal mind-mindedness, and infant attachment behavior. Infant Behavior and Development, 51, 33-44. https://doi.org/10.1016/j.infbeh.2018.02.006 + + + Binda, V., Figueroa-Leigh, F., & Olhaberry, M. (2019). Antenatal and postnatal depressive symptoms: Association with quality of mother-infant interaction. Infant Behavior and Development, 57, 101386. https://doi.org/10.1016/j.infbeh.2019.101386 + + + Booth-LaForce, C., Oxford, M. L., Barbosa-Leiker, C., Burduli, E., & Buchwald, D. S. (2020). Randomized controlled trial of the Promoting First Relationships® preventive intervention for primary caregivers and toddlers in an American Indian community. Prevention Science, 21(1), 98-108. https://doi.org/10.1007/s11121-019-01053-x + + + Booth-LaForce, C., Oxford, M. L., O'Leary, R., & Buchwald, D. S. (2023). Promoting First Relationships® for primary caregivers and toddlers in a Native community: A randomized controlled trial. Prevention Science, 24(1), 39-49. https://doi.org/10.1007/s11121-022-01415-y + + + Bright, K. S., Charrois, E. M., Mughal, M. K., Wajid, A., McNeil, D., Stuart, S., Hayden, K. A., & Kingston, D. (2020). Interpersonal psychotherapy to reduce psychological distress in perinatal women: A systematic review. International Journal of Environmental Research and Public Health, 17(22), 8421. https://doi.org/10.3390/ijerph17228421 + + + Carter, A. S., Briggs-Gowan, M. J., Jones, S. M., & Little, T. D. (2003). Infant Toddler Social Emotional Assessment (ITSEA): Factor structure, reliability, and validity. Journal of Abnormal Child Psychology, 31(5), 495-514. https://doi.org/10.1023/a:1025449031360 + + + Carter, A. S., & Briggs-Gowan, M. J. (2006). ITSEA: Infant-Toddler social and Emotional Assessment examiner's manual. PsychCorp. + + + Cassidy, J., Brett, B. E., Gross, J. T., Stern, J. A., Martin, D. R., Mohr, J. J., & Woodhouse, S. S. (2017). Circle of security-parenting: A randomized controlled trial in Head Start. Development and Psychopathology, 29(2), 651-673. https://doi.org/10.1017/s0954579417000244 + + + Cohen, J. (1988). Statistical power analysis for the behavioral sciences (2nd ed.). Lawrence Erlbaum Associates, Inc. + + + Crittenden, P. M. (1988). Relationships at risk. In J. Belsky & T. Nezworski (Eds.), Clinical implications of attachment (pp. 136-174). Lawrence Erlbaum Associates, Inc. + + + Curry, S. J., Krist, A. H., Owens, D. K., Barry, M. J., Caughey, A. B., Davidson, K. W., Doubeni, C. A., Epling, J. W., Grossman, D. C., & Kemper, A. R. (2019). Interventions to prevent perinatal depression: US Preventive Services Task Force recommendation statement. Journal of the American Medical Association, 321(6), 580-587. https://doi.org/10.1001/jama.2019.0007 + + + Davidson, J., Zisook, S., Giller, E., & Helms, M. (1989). Symptoms of interpersonal sensitivity in depression. Comprehensive Psychiatry, 30(5), 357-368. https://doi.org/10.1016/0010-440x(89)90001-1 + + + Davis, R. (2016). Countering the production of health inequity: An emerging systems framework to achieve an equitable culture of health [Special session]. American Public Health Association Annual Meeting & Expo, Denver, CO, United States. https://apha.confex.com/apha/144am/meetingapp.cgi/Paper/367017 + + + Deragotis, L., Lipman, R., & Covi, L. (1973). SCL-90: An outpatient psychiatric rating scale, preliminary report. Psychopharmacology Bulletin, 9(1), 13-28. + + + Derogatis, L. R., Rickels, K., & Rock, A. F. (1976). The SCL-90 and the MMPI: A step in the validation of a new self-report scale. The British Journal of Psychiatry, 128(3), 280-289. https://doi.org/10.1192/bjp.128.3.280 + + + Duggan, A. K., Berlin, L. J., Cassidy, J., Burrell, L., & Tandon, S. D. (2009). Examining maternal depression and attachment insecurity as moderators of the impacts of home visiting for at-risk mothers and infants. Journal of Consulting and Clinical Psychology, 77(4), 788. https://doi.org/10.1037/a0015709 + + + DuMont, K., Mitchell-Herzfeld, S., Greene, R., Lee, E., Lowenfels, A., & Rodriguez, M. (2006). Healthy Families New York (HFNY) randomized trial: Impacts on parenting after the first two years. New York State Office of Children and Family Services. + + + Fernandes-Alcantara, A. L. (2018). Maternal and Infant Early Childhood Home Visiting (MIECHV) Program: Background and Funding. Congressional Research Service, 18, 1-51. + + + Forman, D. R., O'Hara, M. W., Stuart, S., Gorman, L. L., Larsen, K. E., & Coy, K. C. (2007). Effective treatment for postpartum depression is not sufficient to improve the developing mother-child relationship. Development and Psychopathology, 19(2), 585-602. https://doi.org/10.1017/s0954579407070289 + + + Fukkink, R. G. (2008). Video feedback in widescreen: A meta-analysis of family programs. Clinical Psychology Review, 28(6), 904-916. https://doi.org/10.1016/j.cpr.2008.01.003 + + + Glover, V. (2014). Maternal depression, anxiety and stress during pregnancy and child outcome; what needs to be done. Best Practice and Research. Clinical Obstetrics and Gynaecology, 28(1), 25-35. https://doi.org/10.1016/j.bpobgyn.2013.08.017 + + + Goodman, S. H. (2020). Intergenerational transmission of depression. Annual Review of Clinical Psychology, 16, 213-238. https://doi.org/10.1146/annurev-clinpsy-071519-113915 + + + Goodman, S. H., & Halperin, M. S. (2020). Perinatal depression as an early stress: Risk for the development of psychopathology in children. In K. L. Harkness & E. P. Hayden (Eds.), The Oxford Handbook of Stress and Mental Health. Oxford University Press. https://doi.org/10.1093/oxfordhb/9780190681777.013.13 + + + Goodman, S. H., Rouse, M. H., Connell, A. M., Broth, M. R., Hall, C. M., & Heyward, D. (2011). Maternal depression and child psychopathology: A meta-analytic review. Clinical Child and Family Psychology Review, 14(1), 1-27. https://doi.org/10.1007/s10567-010-0080-1 + + + Graham, J. W. (2009). Missing data analysis: Making it work in the real world. 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An intervention that increases parental sensitivity in families referred to Child Protective Services also changes toddlers' parasympathetic regulation. Developmental Science, 22(1), e12725. https://doi.org/10.1111/desc.12725 + + + Health Measures. (2021). PROMIS Anger/Irritability Scoring Manual. https://www.healthmeasures.net/images/PROMIS/manuals/Scoring_Manuals_/PROMIS_Anger_Irritability_Scoring_Manual.pdf + + + Health Measures. (2023). PROMIS Measure Development and Research. https://www.healthmeasures.net/explore-measurement-systems/promis/measure-development-research + + + Ierardi, E., Ferro, V., Trovato, A., Tambelli, R., & Riva Crugnola, C. (2019). Maternal and paternal depression and anxiety: Their relationship with mother-infant interactions at 3 months. Archives of Women's Mental Health, 22(4), 527-533. https://doi.org/10.1007/s00737-018-0919-x + + + Jones Harden, B. J., Martoccio, T. L., & Berlin, L. J. (2021). 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Cognitive emotion regulation in the prediction of depression, anxiety, stress, and anger. Personality and Individual Differences, 39(7), 1249-1260. https://psycnet.apa.org/doi/10.1016/j.paid.2005.06.004 + + + Meltzer-Brody, S., & Jones, I. (2015). Optimizing the treatment of mood disorders in the perinatal period. Dialogues in Clinical Neuroscience, 17(2), 207. https://doi.org/10.31887/DCNS.2015.17.2/smeltzerbrody + + + Muthén, L. K., & Muthén, B. O. (1998-2015). Mplus user's guide (7th ed.). Muthén & Muthén. + + + Nelson, E. M., & Spieker, S. J. (2013). Intervention effects on morning and stimulated cortisol responses among toddlers in foster care. Infant Mental Health Journal, 34(3). https://doi.org/10.1002/imhj.21382 + + + O'Hara, L., Smith, E. R., Barlow, J., Livingstone, N., Herath, N. I., Wei, Y., Spreckelsen, T. F., & Macdonald, G. (2019). Video feedback for parental sensitivity and attachment security in children under five years. Cochrane Database of Systematic Reviews, 11(7), CD012348. https://doi.org/10.1002/14651858.CD012348.pub2 + + + Olds, D. L., Henderson, Jr, C. R., & Kitzman, H. (1994). Does prenatal and infancy nurse home visitation have enduring effects on qualities of parental caregiving and child health at 25 to 50 months of life? Pediatrics, 93(1), 89-98. https://doi.org/10.1542/peds.93.1.89 + + + Oxford, M. L., Fleming, C. B., Nelson, E. M., Kelly, J. F., & Spieker, S. J. (2013). Randomized trial of Promoting First Relationships: Effects on maltreated toddlers' separation distress and sleep regulation after reunification. Children and Youth Services Review, 35(12), 1988-1992. https://doi.org/10.1016/j.childyouth.2013.09.021 + + + Oxford, M. L., Hash, J. B., Lohr, M. J., Bleil, M. E., Fleming, C. B., Unützer, J., & Spieker, S. J. (2021). Randomized trial of promoting first relationships for new mothers who received community mental health services in pregnancy. Developmental Psychology, 57(8), 1228-1241. https://doi.org/10.1037/dev0001219 + + + Oxford, M. L., Marcenko, M., Fleming, C. B., Lohr, M. J., & Spieker, S. J. (2016). Promoting birth parents' relationships with their toddlers upon reunification: Results from Promoting First Relationships® home visiting program. Children and Youth Services Review, 61, 109-116. https://doi.org/10.1016/j.childyouth.2015.12.004 + + + Oxford, M. L., Spieker, S. J., Lohr, M. J., & Fleming, C. B. (2016). Promoting First Relationships®: Randomized trial of a 10-week home visiting program with families referred to Child Protective Services. Child Maltreatment, 21(4), 267-277. https://doi.org/10.1177/1077559516668274 + + + Oxford, M. L., Spieker, S. J., Lohr, M. J., Fleming, C. B., Dillon, C., & Rees, J. (2018). Ensuring implementation fidelity of a 10-week home visiting program in two randomized clinical trials. Maternal and Child Health Journal, 22, 376-383. https://doi.org/10.1007/s10995-017-2387-8 + + + Parfitt, Y., Pike, A., & Ayers, S. (2013). The impact of parents' mental health on parent-baby interaction: A prospective study. Infant Behavior and Development, 36(4), 599-608. https://doi.org/10.1016/j.infbeh.2013.06.003 + + + Pasalich, D. S., Fleming, C. B., Oxford, M. L., Zheng, Y., & Spieker, S. J. (2016). Can parenting intervention prevent cascading effects from placement instability to insecure attachment to externalizing problems in maltreated toddlers? Child Maltreatment, 21(3), 175-185. https://doi.org/10.1177/1077559516656398 + + + Pasalich, D. S., Fleming, C. B., Spieker, S. J., Lohr, M. J., & Oxford, M. L. (2019). Does parents' own history of child abuse moderate the effectiveness of the Promoting First Relationships® intervention in child welfare? Child Maltreatment, 24(1), 56-65. https://doi.org/10.1177/1077559518809217 + + + Perrone, L., Imrisek, S. D., Dash, A., Rodriguez, M., Monticciolo, E., & Bernard, K. (2021). Changing parental depression and sensitivity: Randomized clinical trial of ABC's effectiveness in the community. Development and Psychopathology, 33(3), 1026-1040. https://doi.org/10.1017/s0954579420000310 + + + Phelps, R. A., & Coker, T. R. (2019). First, do no harm: Improving access in autism diagnostic assessments for children without exacerbating inequities in care. Journal of Developmental & Behavioral Pediatrics, 40(3), 217-218. https://doi.org/10.1097/dbp.0000000000000663 + + + Pocock, S. J. (1983). Clinical trials: A practical approach. Wiley. + + + Poobalan, A. S., Aucott, L. S., Ross, L., Smith, W. C. S., Helms, P. J., & Williams, J. H. (2007). Effects of treating postnatal depression on mother-infant interaction and child development: Systematic review. The British Journal of Psychiatry, 191(5), 378-386. https://doi.org/10.1192/bjp.bp.106.032789 + + + Rogers, A., Obst, S., Teague, S. J., Rosen, L., Spry, E. A., Macdonald, J. A., Sunderland, M., Olsson, C. A., Youssef, G., & Hutchinson, D. (2020). Association between maternal perinatal depression and anxiety and child and adolescent development: A meta-analysis. JAMA Pediatrics, 174(11), 1082-1092. https://doi.org/10.1001/jamapediatrics.2020.2910 + + + Sama-Miller, E., Akers, L., Mraz-Esposito, A., Zukiewicz, M., Avellar, S., Paulsell, D., & Del Grosso, P. (2017). Home visiting evidence of effectiveness review: Executive summary. Office of Planning, Research and Evaluation, Administration for Children and Families, U.S. Department of Health and Human Services. https://www.acf.hhs.gov/sites/default/files/documents/opre/HomVEE_Executive%20Summary%20August%202017.pdf + + + Schalet, B. D., Pilkonis, P. A., Yu, L., Dodds, N., Johnston, K. L., Yount, S., Riley, W., & Cella, D. (2016). Clinical validity of PROMIS depression, anxiety, and anger across diverse clinical samples. Journal of Clinical Epidemiology, 73, 119-127. https://doi.org/10.1016/j.jclinepi.2015.08.036 + + + Schechter, D. S., Myers, M. M., Brunelli, S. A., Coates, S. W., Zeanah, J., Charles, H., Davies, M., Grienenberger, J. F., Marshall, R. D., McCaw, J. E., & Trabka, K. A. (2006). Traumatized mothers can change their minds about their toddlers: Understanding how a novel use of videofeedback supports positive change of maternal attributions. Infant Mental Health Journal, 27(5), 429-447. https://doi.org/10.1002/imhj.20101 + + + Seifer, R., Dickstein, S., Sameroff, A. J., Magee, K. D., & Hayden, L. C. (2001). Infant mental health and variability of parental depression symptoms. Journal of the American Academy of Child and Adolescent Psychiatry, 40(12), 1375-1382. https://doi.org/10.1097/00004583-200112000-00007 + + + Shonkoff, J. P. (2015). Developmental origins of healthy brain development: From evidence to policy. Harvard University. + + + Spieker, S. J., Oxford, M. L., & Fleming, C. B. (2014). Permanency outcomes for toddlers in child welfare two years after a randomized trial of a parenting intervention. Children and Youth Services Review, 44, 201-206. https://doi.org/10.1016/j.childyouth.2014.06.017 + + + Spieker, S. J., Oxford, M. L., Kelly, J. F., Nelson, E. M., & Fleming, C. B. (2012). Promoting First Relationships: Randomized trial of a relationship-based intervention for toddlers in child welfare. Child Maltreatment, 17(4), 271-286. https://doi.org/10.1177/1077559512458176 + + + Spitzer, R. L., Kroenke, K., & Williams, J. B. (1999). Validation and utility of a self-report version of PRIME-MD: The PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. JAMA, 282(18), 1737-1744. https://doi.org/10.1001/jama.282.18.1737 + + + Spitzer, R. L., Kroenke, K., Williams, J. B., & Löwe, B. (2006). A brief measure for assessing generalized anxiety disorder: The GAD-7. 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D., Bakeman, R., Castral, T., & Mirlashari, J. (2016). The relationship of prenatal maternal depression or anxiety to maternal caregiving behavior and infant behavior self-regulation during infant heel lance: An ethological time-based study of behavior. BMC Pregnancy and Childbirth, 16, 264. https://doi.org/10.1186/s12884-016-1050-5 + + + Zahr, L. K. (1991). The relationship between maternal confidence and mother-infant behaviors in premature infants. Research in Nursing & Health, 14, 279-286. https://doi.org/10.1002/nur.4770140406 + + + +
+ + + 36917194 + + 2023 + 03 + 14 + +
+ + 2325-6621 + + + 2023 + Mar + 14 + + + Annals of the American Thoracic Society + Ann Am Thorac Soc + + Morning Chronotype Is Associated with Improved Adherence to Continuous Positive Airway Pressure among Individuals with Obstructive Sleep Apnea. + 10.1513/AnnalsATS.202210-885OC + + Poor adherence limits the effectiveness of continuous positive airway pressure (CPAP) therapy for obstructive sleep apnea (OSA). A better understanding of CPAP adherence is needed to develop novel strategies to improve it. + To determine if chronotype (morning, evening or intermediate) of patients with OSA is associated with differences in CPAP adherence. If such an association exists, to determine the mechanisms underlying this association. + We performed a secondary analysis of the Apnea Positive Pressure Long-term Efficacy Study (APPLES) clinical trial. We assessed chronotype using the Morningness-Eveningness Questionnaire (MEQ) among participants randomized to the CPAP arm with daily adherence data (n=469). Evening (MEQ ≤ 41), intermediate (41 < MEQ < 59) and morning type (MEQ ≥ 59) categories were the exposures. We modeled daily CPAP use (hours per night) over a 6-month period, using a linear mixed model, adjusted for covariates (e.g., age, sex, marital status). To assess mechanisms of the association, we performed mediation analyses using sleep duration, weekend catch-up sleep, depression, and other factors. + Most participants were obese men with severe OSA (body mass index of 32.3 ± 7.3 kg/m2, 65% male and AHI 39.8 ± 24.6 per hour respectively). Participants were 44% morning, 47% intermediate and 8% evening chronotype. Participants with morning chronotype reported the shortest sleep duration on weekends (7.3 vs. 7.6 and 7.9 hours per night) compared to the intermediate and evening types. Participants with morning chronotype exhibited a 40-minutes per night higher CPAP use (p=0.001) compared to persons with intermediate chronotype. This relationship was mildly attenuated (32.8 minutes per night, p = 0.011) after adjustment for covariates. None of the selected factors (e.g., sleep duration, weekend catch-up sleep) exhibited a significant mediation effect. + Morning chronotype is associated with a clinically meaningful, increase in CPAP adherence compared with other chronotypes. Mechanisms of this association require further study. Chronotype maybe a novel predictor of CPAP adherence. + This analysis was a secondary analysis of the Apnea Positive Pressure Long-term Efficacy Study (APPLES) trial (clinicaltrials.gov registration: NCT00051363). + + + + Knauert + Melissa P + MP + + Yale School of Medicine, 12228, Internal Medicine, New Haven, Connecticut, United States; melissa.knauert@yale.edu. + + + + Adekolu + Olurotimi + O + + Yale School of Medicine, 12228, Internal Medicine, New Haven, Connecticut, United States. + + + + Xu + Zhichao + Z + + Yale University School of Public Health, 50296, Biostatistics, New Haven, Connecticut, United States. + + + + Deng + Annan + A + + Yale University School of Public Health, 50296, Biostatistics, New Haven, Connecticut, United States. + + + + Chu + Jen-Hwa + JH + + Yale University School of Public Health, 50296, Biostatistics, New Haven, Connecticut, United States. + + + + Baldassarri + Stephen + S + + Yale University School of Medicine, 12228, New Haven, Connecticut, United States. + + + + Kushida + Clete + C + + Stanford University School of Medicine, 10624, Stanford, California, United States. + + + + Yaggi + H Klar + HK + + Yale School of Medicine, 12228, Internal Medicine, New Haven, Connecticut, United States. + + + + Zinchuk + Andrey + A + 0000-0003-0488-9778 + + Yale School of Medicine, 12228, Internal Medicine, New Haven, Connecticut, United States. + + + + eng + + + ClinicalTrials.gov + + NCT00051363 + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Ann Am Thorac Soc + 101600811 + 2325-6621 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917194 + 10.1513/AnnalsATS.202210-885OC + + +
+ + + 36917196 + + 2023 + 03 + 14 + +
+ + 1558-8238 + + + 2023 + Mar + 14 + + + The Journal of clinical investigation + J Clin Invest + + An IGFBP7high endothelial cell subset drives T cell extravasation in psoriasis via endothelial glycocalyx degradation. + 10.1172/JCI160451 + e160451 + + Dysfunction of vascular endothelial cells (ECs) facilitates imbalanced immune responses and tissue hyperinflammation. However, the heterogeneous functions of skin ECs and their underlying mechanism in dermatoses remain to be solved. Here, focusing on the pathogenic role of skin ECs in psoriasis, we characterized the molecular and functional heterogeneity of skin ECs from healthy individuals and psoriasis patients at the single-cell level. We found that endothelial glycocalyx destruction, a major feature of EC dysfunction in psoriasis, was a driving force during the process of T cell extravasation. Interestingly, we identified a skin EC subset, IGFBP7high ECs, in psoriasis. This subset actively responded to psoriatic-related cytokine signaling, secreted IGFBP7, damaged the endothelial glycocalyx, exposed the adhesion molecules underneath, and prepared the endothelium for immune cell adhesion and transmigration, thus aggravating skin inflammation. More importantly, we provided evidence in a psoriasis-like mouse model that anti-IGFBP7 treatment showed promising therapeutic effects for restoring the endothelial glycocalyx and alleviating skin inflammation. Taken together, our results depicted the distinct functions of EC clusters in healthy and psoriatic skin, identified IGFBP7high ECs as an active subset modulating vascular function and cutaneous inflammation, and indicated that targeting IGFBP7 is a potential therapeutic strategy in psoriasis. + + + + Li + Qingyang + Q + + Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xian, China. + + + + Shao + Shuai + S + + Dermatology of Dermatology, Xijing Hospital, Fourth Military Medical University, Xian, China. + + + + Zhu + Zhenlai + Z + + Dermatology of Dermatology, Xijing Hospital, Fourth Military Medical University, Xian, China. + + + + Chen + Jiaoling + J + + Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xian, China. + + + + Hao + Junfeng + J + + Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xian, China. + + + + Bai + Yaxing + Y + + Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xian, China. + + + + Li + Bing + B + + Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xian, China. + + + + Dang + Erle + E + + Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xian, China. + + + + Wang + Gang + G + + Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xian, China. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + J Clin Invest + 7802877 + 0021-9738 + + IM + + Endothelial cells + Inflammation + Skin + Vascular Biology + +
+ + + + 2023 + 3 + 14 + 12 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917196 + 160451 + 10.1172/JCI160451 + + +
+ + + 36917198 + + 2023 + 03 + 14 + +
+ + 2379-3708 + + + 2023 + Mar + 14 + + + JCI insight + JCI Insight + + GLUT1 is redundant in hypoxic and glycolytic nucleus pulposus cells of the intervertebral disc. + 10.1172/jci.insight.164883 + e164883 + + Glycolysis is central to homeostasis of nucleus pulposus (NP) cells in the avascular intervertebral disc. Since the glucose importer, GLUT1, is a highly enriched phenotypic marker of NP cells, we hypothesized that it is vital for the development and post-natal maintenance of the disc. Surprisingly, primary NP cells treated with two well-characterized GLUT1 inhibitors maintained normal rates of glycolysis and ATP production, indicating intrinsic compensatory mechanisms. We show in vitro that NP cells mitigate GLUT1 loss by rewiring glucose import through GLUT3. Noteworthy, we demonstrate that substrates, such as glutamine and palmitate, do not compensate for glucose restriction resulting from dual inhibition of GLUT1/3 and inhibition compromises long-term cell viability. To investigate the redundancy of GLUT1 function in NP, we generated two NP-specific knockout mice: Krt19CreERT; Glut1f/f and Foxa2Cre; Glut1f/f. Noteworthy, there were no apparent defects in post-natal disc health or development and maturation in mutant mice. Microarray analysis confirmed that GLUT1 loss did not cause transcriptomic alterations in the NP, supporting that cells are refractory to GLUT1 loss. These observations provide the first evidence of functional redundancy in GLUT transporters in the physiologically hypoxic intervertebral disc and underscore the importance of glucose as the indispensable substrate for NP cells. + + + + Johnston + Shira N + SN + + Department of Orthopeadic Surgery, Thomas Jefferson University, Philadelphia, United States of America. + + + + Silagi + Elizabeth S + ES + + Neurobiology, Harvard Medical School, Dana-Farber Cancer Institute, Harvard University, Boston, United States of America. + + + + Madhu + Vedavathi + V + + Department of Orthopeadic Surgery, Thomas Jefferson University, Philadelphia, United States of America. + + + + Nguyen + Duc H + DH + + Department of Orthopeadic Surgery, Thomas Jefferson University, Philadelphia, United States of America. + + + + Shapiro + Irving M + IM + + Department of Orthopeadic Surgery, Thomas Jefferson University, Philadelphia, United States of America. + + + + Risbud + Makarand V + MV + + Department of Orthopeadic Surgery, Thomas Jefferson University, Philadelphia, United States of America. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + JCI Insight + 101676073 + 2379-3708 + + IM + + Bone Biology + Cartilage + Glucose metabolism + Hypoxia + Metabolism + +
+ + + + 2023 + 3 + 14 + 12 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917198 + 164883 + 10.1172/jci.insight.164883 + + +
+ + + 36917202 + + 2023 + 03 + 14 + +
+ + 1520-5118 + + + 2023 + Mar + 14 + + + Journal of agricultural and food chemistry + J Agric Food Chem + + Ellagitannin Punicalagin Disrupts the Pathways Related to Bacterial Growth and Affects Multiple Pattern Recognition Receptor Signaling by Acting as a Selective Histone Deacetylase Inhibitor. + 10.1021/acs.jafc.2c08738 + + Punicalagin (PA) is a key ellagitannin abundant in pomegranate with wide-ranging biological activities. In this study, we examined the biological processes by which PA regulates bacterial growth and inflammation in human cells using multiomics and molecular docking approaches. PA promoted macrophage-mediated bacterial killing and inhibited the growth of Citrobacter rodentium by inducing a distinct metabolome pattern. PA acted as a selective regulator of histone deacetylases (HDACs) and affected 37 pathways in macrophages, including signaling mediated by pattern recognition receptors, such as Toll-like and NOD-like receptors. In silico simulation showed that PA can bind with high affinity to HDAC7. PA downregulated HDAC7 at both mRNA and protein levels and resulted in a decrease in the level of histone 3 lysine 27 acetylation. Our findings provide evidence that PA exerts its biological effects via multiple pathways, which can be exploited in the development of this bioactive food ingredient for disease management. + + + + Liu + Fang + F + 0000-0002-7099-9310 + + College of Public Health, Zhengzhou University, Zhengzhou 450001, China. + + + + Smith + Allen D + AD + + Diet, Genomics and Immunology Laboratory, USDA-ARS, Beltsville, Maryland 20705, United States. + + + + Wang + Thomas T Y + TTY + 0000-0003-2299-9452 + + Diet, Genomics and Immunology Laboratory, USDA-ARS, Beltsville, Maryland 20705, United States. + + + + Pham + Quynhchi + Q + + Diet, Genomics and Immunology Laboratory, USDA-ARS, Beltsville, Maryland 20705, United States. + + + + Yang + Haiyan + H + + College of Public Health, Zhengzhou University, Zhengzhou 450001, China. + + + + Li + Robert W + RW + 0000-0001-9220-7049 + + Animal Parasitic Diseases Laboratory, USDA-ARS, Beltsville, Maryland 20705, United States. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + J Agric Food Chem + 0374755 + 0021-8561 + + IM + + Citrobacter + HDAC + ellagitannin + metabolome + punicalagin + +
+ + + + 2023 + 3 + 14 + 12 + 4 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917202 + 10.1021/acs.jafc.2c08738 + + +
+ + + 36917200 + + 2023 + 03 + 14 + +
+ + 1536-4844 + + + 2023 + Mar + 14 + + + Inflammatory bowel diseases + Inflamm Bowel Dis + + Hospitalization Rates for Inflammatory Bowel Disease Are Decreasing Over Time: A Population-based Cohort Study. + izad020 + 10.1093/ibd/izad020 + + Recent advances in the management of inflammatory bowel disease (IBD) striving for new treatment targets may have decreased rates of hospitalization for flares. We compared all-cause, IBD-related, and non-IBD-related hospitalizations while accounting for the rising prevalence of IBD. + Population-based, administrative health care databases identified all individuals living with IBD in Alberta between fiscal year 2002 and 2018. Hospitalization rates (all-cause, IBD-related, and non-IBD-related) were calculated using the prevalent Alberta IBD population. Hospitalizations were stratified by disease type, age, sex, and metropolitan status. Data were age and sex standardized to the 2019 Canadian population. Log-linear models calculated Average Annual Percentage Change (AAPC) in hospitalization rates with associated 95% confidence intervals (CIs). + From 2002-2003 to 2018-2019, all-cause hospitalization rates decreased from 36.57 to 16.72 per 100 IBD patients (AAPC, -4.18%; 95% CI, -4.69 to -3.66). Inflammatory bowel disease-related hospitalization rate decreased from 26.44 to 9.24 per 100 IBD patients (AAPC, -5.54%; 95% CI, -6.19 to -4.88). Non-IBD-related hospitalization rate decreased from 10.13 to 7.48 per 100 IBD patients (AAPC, -1.82%; 95% CI, -2.14 to -1.49). Those over 80 years old had the greatest all-cause and non-IBD-related hospitalization rates. Temporal trends showing decreasing hospitalization rates were observed across age, sex, IBD type, and metropolitan status. + Hospitalization rates are decreasing for all-cause, IBD-related, and non-IBD-related hospitalizations. Over the past 20 years, the care of IBD has transitioned from hospital-based care to ambulatory-centric IBD management. + © 2023 Crohn’s & Colitis Foundation. Published by Oxford University Press on behalf of Crohn’s & Colitis Foundation. + + + + Buie + Michael J + MJ + + Department of Medicine, University of Calgary, Calgary, Alberta, Canada. + + + Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada. + + + + Coward + Stephanie + S + 0000-0003-0675-7226 + + Department of Medicine, University of Calgary, Calgary, Alberta, Canada. + + + Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada. + + + + Shaheen + Abdel-Aziz + AA + + Department of Medicine, University of Calgary, Calgary, Alberta, Canada. + + + Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada. + + + + Holroyd-Leduc + Jayna + J + + Department of Medicine, University of Calgary, Calgary, Alberta, Canada. + + + Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada. + + + + Hracs + Lindsay + L + + Department of Medicine, University of Calgary, Calgary, Alberta, Canada. + + + Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada. + + + + Ma + Christopher + C + 0000-0002-4698-9948 + + Department of Medicine, University of Calgary, Calgary, Alberta, Canada. + + + Division of Gastroenterology and Hepatology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada. + + + + Panaccione + Remo + R + + Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada. + + + Division of Gastroenterology and Hepatology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada. + + + + Benchimol + Eric I + EI + + SickKids Inflammatory Bowel Disease Centre, Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Toronto, Ontario, Canada. + + + Child Health Evaluative Sciences, SickKids Research Institute, Toronto, Ontario, Canada. + + + Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada. + + + Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada. + + + Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada. + + + + Bernstein + Charles N + CN + + Department of Medicine, and the University of Manitoba IBD Clinical and Research Centre, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada. + + + + Bitton + Alain + A + + Division of Gastroenterology and Hepatology, McGill University and McGill University Health Centre, Montreal, Quebec, Canada. + + + + Otley + Anthony R + AR + + Department of Pediatrics, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada. + + + + Jones + Jennifer L + JL + 0000-0002-6380-6728 + + Division of Digestive Care & Endoscopy, Department of Medicine, Dalhousie University, Halifax, NS, Canada. + + + + Murthy + Sanjay K + SK + + Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada. + + + Division of Gastroenterology, The Ottawa Hospital IBD Centre, Ottawa, Ontario, Canada. + + + Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada. + + + School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada. + + + + Ellen Kuenzig + M + M + + SickKids Inflammatory Bowel Disease Centre, Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Toronto, Ontario, Canada. + + + Child Health Evaluative Sciences, SickKids Research Institute, Toronto, Ontario, Canada. + + + + Peña-Sánchez + Juan-Nicolás + JN + + Department of Community Health and Epidemiology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada. + + + + Targownik + Laura E + LE + + Zane Cohen Centre for Digestive Diseases, Mount Sinai Health, Toronto, Ontario, Canada. + + + + Singh + Harminder + H + 0000-0002-9354-2356 + + Departments of Medicine and Community Health Sciences, University of Manitoba, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada. + + + Research Institute, CancerCare, Winnipeg, Manitoba, Canada. + + + + Avina-Zubieta + Antonio + A + + Division of Rheumatology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. + + + + Kaplan + Gilaad G + GG + 0000-0003-2719-0556 + + Department of Medicine, University of Calgary, Calgary, Alberta, Canada. + + + Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada. + + + + eng + + + PJT-162393 + Canadian Institutes of Health Research + Canada + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + England + Inflamm Bowel Dis + 9508162 + 1078-0998 + + IM + + Hospitalization rates per 100 IBD patients are decreasing. However, when using the general population as the denominator, the interpretation of temporal trends changes because the prevalence of IBD has risen faster than the general population’s growth rate. + + + Crohn’s disease + epidemiology + hospitalization rates + inflammatory bowel disease + ulcerative colitis + +
+ + + + 2022 + 12 + 15 + + + 2023 + 3 + 14 + 12 + 4 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917200 + 7077421 + 10.1093/ibd/izad020 + + +
+ + + 36917201 + + 2023 + 03 + 14 + +
+ + 1520-6882 + + + 2023 + Mar + 14 + + + Analytical chemistry + Anal Chem + + Magnetic DNA Nanomachine for On-Particle Cascade Amplification-Based Ferromagnetic Resonance Detection of Plant MicroRNA. + 10.1021/acs.analchem.3c00065 + + Plant microRNAs play critical roles in post-transcriptional gene regulation of many processes, thus motivating the development of accurate and user-friendly microRNA detection methods for better understanding of, e.g., plant growth, development, and abiotic/biotic stress responses. By integrating the capture probe, fuel strand, primer, and template onto the surface of a magnetic nanoparticle (MNP), we demonstrated a magnetic DNA nanomachine that could conduct an on-particle cascade amplification reaction in response to the presence of target microRNA. The cascade amplification consists of an exonuclease III-assisted target recycling step and a rolling circle amplification step, leading to changes in the MNP arrangement that can be quantified by ferromagnetic resonance spectroscopy. After a careful investigation of the exonuclease III side reaction, the biosensor offers a detection limit of 15 fM with a total assay time of ca. 70 min. Moreover, our magnetic DNA nanomachine is capable of discriminating the target microRNA from its family members. Our biosensor has also been tested on total endogenous microRNAs extracted from Arabidopsis thaliana leaves, with a performance comparable to qRT-PCR. + + + + Chen + Li + L + + State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan Provincial Key Laboratory of Plant Functional Genomics and Developmental Regulation, College of Biology, Hunan University, Changsha 410082, China. + + + + Fang + Yuan + Y + + State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan Provincial Key Laboratory of Plant Functional Genomics and Developmental Regulation, College of Biology, Hunan University, Changsha 410082, China. + + + Department of Biomedical Engineering, School of Basic Medical Science, Central South University, Changsha 410013, China. + + + + Zhou + Xuemei + X + + State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan Provincial Key Laboratory of Plant Functional Genomics and Developmental Regulation, College of Biology, Hunan University, Changsha 410082, China. + + + + Zhang + Meng + M + + State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan Provincial Key Laboratory of Plant Functional Genomics and Developmental Regulation, College of Biology, Hunan University, Changsha 410082, China. + + + + Yao + Ruifeng + R + + State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan Provincial Key Laboratory of Plant Functional Genomics and Developmental Regulation, College of Biology, Hunan University, Changsha 410082, China. + + + + Tian + Bo + B + 0000-0002-5249-4415 + + Department of Biomedical Engineering, School of Basic Medical Science, Central South University, Changsha 410013, China. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Anal Chem + 0370536 + 0003-2700 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 4 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917201 + 10.1021/acs.analchem.3c00065 + + +
+ + + 36917207 + + 2023 + 03 + 14 + +
+ + 1439-7633 + + + 2023 + Mar + 14 + + + Chembiochem : a European journal of chemical biology + Chembiochem + + Incorporating a Polyethyleneglycol Linker to Enhance the Hydrophilicity of Mitochondria-Targeted Triphenylphosphonium Constructs. + + e202200774 + + 10.1002/cbic.202200774 + + The targeting of bioactive molecules and probes to mitochondria can be achieved by coupling to the lipophilic triphenyl phosphonium (TPP) cation, which accumulates several hundred-fold within mitochondria in response to the mitochondrial membrane potential (Dym). Typically, a simple alkane links the TPP to its "cargo", increasing overall hydrophobicity. As it would be beneficial to enhance the water solubility of mitochondria-targeted compounds we explored the effects of replacing the alkyl linker with a polyethylene glycol (PEG). We found that the use of PEG led to compounds that were readily taken up by isolated mitochondria and by mitochondria inside cells. Within mitochondria the PEG linker greatly decreased adsorption of the TPP constructs to the matrix-facing face of the mitochondrial inner membrane. These findings will allow the distribution of mitochondria-targeted TPP compounds within mitochondria to be fine-tuned. + © 2023 Wiley-VCH GmbH. + + + + Uno + Shinpei + S + + University of Cambridge, MRC Mitochondrial Biology Unit, UNITED KINGDOM. + + + + Harkiss + Alexander + A + + University of Glasgow, Chemistry, UNITED KINGDOM. + + + + Chowdhury + Roy + R + + University of Cambridge, MRC-MBU, UNITED KINGDOM. + + + + Caldwell + Stuart + S + + University of Glasgow, Chemistry, UNITED KINGDOM. + + + + Prime + Tracy + T + + University of Cambridge, MRC MBU, UNITED KINGDOM. + + + + James + Andrew + A + + University of Cambridge, MRC MBU, UNITED KINGDOM. + + + + Gallagher + Brendan + B + + University of Cambridge, Chemistry, UNITED KINGDOM. + + + + Prudent + Julien + J + + University of Cambridge, MRC MBU, UNITED KINGDOM. + + + + Hartley + Richard + R + + University of Glasgow, Chemistry, UNITED KINGDOM. + + + + Murphy + Michael + M + + MRC Mitochondrial Biology Unit, MBU, Hills Road, cb2 0XY, Cambridge, UNITED KINGDOM. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Chembiochem + 100937360 + 1439-4227 + + IM + + biological membrane + lipophilic cation + mitochondria-targeting + polyethylene glycol + triphenylphosphonium + +
+ + + + 2023 + 02 + 22 + + + 2022 + 12 + 23 + + + 2023 + 03 + 14 + + + 2023 + 3 + 14 + 12 + 4 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917207 + 10.1002/cbic.202200774 + + +
+ + + 36917213 + + 2023 + 03 + 14 + +
+ + 1937-6995 + + + 2023 + Mar + 14 + + + Journal of medical toxicology : official journal of the American College of Medical Toxicology + J Med Toxicol + + Our Appreciation and Gratitude to Journal of Medical Toxicology (JMT) Peer Reviewers in 2022. + 10.1007/s13181-023-00939-1 + + + Mycyk + Mark B + MB + http://orcid.org/0000-0002-8935-9962 + + Cook County Health, Chicago, IL, USA. jmtinfo@acmt.net. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + J Med Toxicol + 101284598 + 1556-9039 + + IM + + Ethical scholarship + Peer review + Publishing + +
+ + + + 2023 + 3 + 14 + 12 + 4 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917213 + 10.1007/s13181-023-00939-1 + 10.1007/s13181-023-00939-1 + + +
+ + + 36917199 + + 2023 + 03 + 14 + +
+ + 1096-8652 + + + 2023 + Mar + 14 + + + American journal of hematology + Am J Hematol + + Complement inhibition in Medicine: Hematology and beyond; Complement inhibition in Hematology: PNH and beyond. + 10.1002/ajh.26912 + + + Peffault de Latour + Régis + R + https://orcid.org/0000-0001-6222-4753 + + French Reference Center for Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria, Assistance Publique - Hôpitaux de Paris, Saint-Louis Hospital, Université Paris Cité, Paris, France. + + + + Risitano + Antonio M + AM + https://orcid.org/0000-0002-4744-5109 + + AORN San Giuseppe Moscati Avellino, Italy. + + + Federico II University, Naples. + + + + eng + + Editorial + + + 2023 + 03 + 14 + +
+ + United States + Am J Hematol + 7610369 + 0361-8609 + + IM +
+ + + + 2023 + 02 + 22 + + + 2023 + 02 + 27 + + + 2023 + 3 + 14 + 12 + 4 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917199 + 10.1002/ajh.26912 + + +
+ + + 36917206 + + 2023 + 03 + 14 + +
+ + 1440-1819 + + + 2023 + Mar + 14 + + + Psychiatry and clinical neurosciences + Psychiatry Clin Neurosci + + Long-term benefits of mindfulness on white matter tracts underlying the cortical midline structures in panic disorder: a 2-year longitudinal study. + 10.1111/pcn.13544 + + We aimed to examine the long-term benefits of mindfulness-based cognitive therapy (MBCT) on white matter plasticity in the cortical midline structures (CMS) for a period of 2 years in patients with panic disorder and the relationships between white matter changes in the CMS and severity of state and trait symptoms. + Seventy-one participants were enrolled and underwent diffusion tensor imaging at baseline and after 2 years (26 who received MBCT as an adjunct to pharmacotherapy [MBCT+PT], 20 treated with pharmacotherapy alone [PT-alone], and 25 healthy controls [HCs]). The severity of symptoms and fractional anisotropy (FA) in white matter regions underlying the CMS were assessed at baseline and 2-year follow-up. + The MBCT+PT group showed better outcomes after 2 years than the PT-alone group. The groups showed different FA changes: the MBCT+PT group showed decreased FA in the left anterior cingulate cortex (ACC); the PT-alone group showed increased FA in the bilateral dorsomedial prefrontal cortex, posterior cingulate cortex (PCC), and precuneus. Decreased white matter FA in the ACC, PCC, and precuneus was associated with improvements in the severity of state and trait symptoms in patients with panic disorder. + Alleviation of excessive white matter connectivity in the CMS after MBCT leads to improvements in clinical symptoms and trait vulnerability in patients with panic disorder. Our study provides new evidence for the long-term benefits of MBCT on white matter plasticity and its clinical applicability as a robust treatment for panic disorder. This article is protected by copyright. All rights reserved. + This article is protected by copyright. All rights reserved. + + + + Bang + Minji + M + https://orcid.org/0000-0002-1669-4014 + + Department of Psychiatry, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea. + + + + Kim + Borah + B + + Department of Psychiatry, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea. + + + + Lee + Kang Soo + KS + + Department of Psychiatry, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea. + + + + Choi + Tai Kiu + TK + + Department of Psychiatry, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea. + + + + Lee + Sang-Hyuk + SH + https://orcid.org/0000-0001-9097-261X + + Department of Psychiatry, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Australia + Psychiatry Clin Neurosci + 9513551 + 1323-1316 + + IM + + cortical midline structures + diffusion tensor imaging + mindfulness + panic disorder + white matter + +
+ + + + 2023 + 03 + 08 + + + 2022 + 09 + 26 + + + 2023 + 03 + 10 + + + 2023 + 3 + 14 + 12 + 4 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917206 + 10.1111/pcn.13544 + + +
+ + + 36917203 + + 2023 + 03 + 14 + +
+ + 1432-2129 + + + 2023 + Mar + 14 + + + Schmerz (Berlin, Germany) + Schmerz + + [Clinical trials as a central part of patient-centered clinical research]. + 10.1007/s00482-023-00712-x + + As the continuation and implementation of findings from basic (pre‑)clinical research, clinical trials make a significant contribution to medical research. They form the central building block of translational medicine and thus make a decisive contribution to bringing medical knowledge into general care. This helps to make possible a healthcare system that is aligned to the needs of patients and functions efficiently in the long term. Based on the specific objective, clinical trials must comply with national, but increasingly also with European and international regulatory requirements. In academia in particular, expertise in a variety of fields is required in order to make investigator-driven clinical trials a success. This expertise can be provided by a clinical trial center based within the institution conducting the trial. + © 2023. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature. + + + + Gavenis + Karsten + K + + Studienzentrum, Universitätsmedizin Göttingen, Göttingen, Deutschland. karsten.gavenis@med.uni-goettingen.de. + + + Deutsches Studienzentrum HNO und Studienzentrum UMG, Von-Bar-Straße 2/4, 37075, Göttingen, Deutschland. karsten.gavenis@med.uni-goettingen.de. + + + + Guntinas-Lichius + Orlando + O + + Klinik für Hals‑, Nasen- und Ohrenheilkunde, Universitätsklinikum Jena, Jena, Deutschland. + + + + Löhler + Jan + J + + HNO-Praxis Bad Bramstedt, Bad Bramstedt, Deutschland. + + + + Tostmann + Ralf + R + + Studienzentrum, Universitätsmedizin Göttingen, Göttingen, Deutschland. + + + + Asendorf + Thomas + T + + Institut für Medizinische Statistik, Universitätsmedizin Göttingen, Göttingen, Deutschland. + + + + ger + + English Abstract + Journal Article + + Klinische Studien als zentraler Bestandteil patientenorientierter Forschung. + + 2023 + 03 + 14 + +
+ + Germany + Schmerz + 8906258 + 0932-433X + + IM + + Als Fortführung und Umsetzung der Erkenntnisse grundlagenorientierter (prä)klinischer Forschung leisten klinische Studien einen wesentlichen Beitrag zum medizinischen Fortschritt. Sie bilden den zentralen Baustein der translationalen Medizin und tragen so entscheidend dazu bei, medizinische Erkenntnisse in die allgemeine Versorgung einzubringen. Hierdurch wird ein langfristig effizientes, an den Bedürfnissen des Patienten orientiertes Gesundheitssystem wesentlich mit ermöglicht. Basierend auf der konkreten Zielsetzung müssen klinische Studien nationale, in zunehmendem Maße aber auch europäische und internationale regulatorische Vorgaben einhalten. Insbesondere im akademischen Bereich bedarf es hierbei der Expertise auf einer Vielzahl von Feldern, um wissenschaftsinitiierte klinische Studien zum Erfolg zu führen. Diese Expertise kann durch die Etablierung eines an die studiendurchführende Einrichtung angelehnten Studienzentrums bereitgestellt werden. + + + Biomedical translational science + Clinical trials as topic + Health care evaluation mechanisms + Patient-centered outcomes research + Quality assurance, health care + +
+ + + + 2022 + 09 + 09 + + + 2023 + 3 + 14 + 12 + 4 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917203 + 10.1007/s00482-023-00712-x + 10.1007/s00482-023-00712-x + + + Literatur + + https://www.tmf-ev.de/home.aspx . Zugegriffen: 13. Juli 2022 + + + https://www.vfa.de/de/arzneimittel-forschung/forschungsstandort-deutschland/klinische-studien-deutschland.html . Zugegriffen: 13. Juli 2022 + + + Röhrig B, Du Prel J‑B, Wachtlin D, Blettner M (2009) Studientypen in der medizinischen Forschung. Dtsch Arztebl 15:262–268 + + + Verordnung (EU) 2017/745 Des Europäischen Parlaments Und Des Rates vom 5. April 2017 über Medizinprodukte, zur Änderung der Richtlinie 2001/83/EG, der Verordnung (EG) Nr. 178/2002 und der Verordnung (EG) Nr. 1223/2009 und zur Aufhebung der Richtlinien 90/385/EWG und 93/42/EWG des Rates + + + Gesetz zur Durchführung unionsrechtlicher Vorschriften betreffend Medizinprodukte (Medizinprodukterecht-Durchführungsgesetz – MPDG) + + + Verordnung (EU) 2017/746 Des Europäischen Parlaments Und Des Rates vom 5. April 2017 über In-vitro-Diagnostika und zur Aufhebung der Richtlinie 98/79/EG und des Beschlusses 2010/227/EU der Kommission + + + Richtlinie 2001/20/EG Des Europäischen Parlaments Und Des Rates vom 4. April 2001 zur Angleichung der Rechts- und Verwaltungsvorschriften der Mitgliedstaaten über die Anwendung der guten klinischen Praxis bei der Durchführung von klinischen Prüfungen mit Humanarzneimitteln + + + Verordnung (EU) Nr. 536/2014 Des Europäischen Parlaments Und Des Rates vom 16. April 2014 über klinische Prüfungen mit Humanarzneimitteln und zur Aufhebung der Richtlinie 2001/20/EG + + + (Muster‑)Berufsordnung für die in Deutschland tätigen Ärztinnen und Ärzte + + + WMA Deklaration von Helsinki – Ethische Grundsätze für die medizinische Forschung am Menschen. Letzte Revision: 2013 + + + https://www.kks-netzwerk.de . Zugegriffen: 13. Juli 2022 + + + https://dsz-hno.hno.org/studienportal.html . Zugegriffen: 13. Juli 2022 + + + +
+ + + 36917205 + + 2023 + 03 + 14 + +
+ + 1521-3773 + + + 2023 + Mar + 14 + + + Angewandte Chemie (International ed. in English) + Angew Chem Int Ed Engl + + Single-Benzene Dual-Emitters Harness Excited-State Antiaromaticity for White Light Generation and Fluorescence Imaging. + + e202302107 + + 10.1002/anie.202302107 + + Molecular emitters simultaneously generating light at different wavelengths have wide applications. With a small molecule, however, it is challenging to realize two independent radiative pathways. We invented the first examples of dual-emissive single-benzene fluorophores (SBFs). Two emissive tautomers are generated by synthetic modulation of the hydrogen bond acidity, which opens up pathways for excited-state proton transfer. White light is produced by a delicate balance between the energy and intensity of the radiative decay from each tautomer. We show that the excited-state antiaromaticity of the benzene core itself dictates the proton movements driving the tautomer equilibrium. Using this simple benzene platform, a fluorinated SBF was synthesized with a record high solubility in perfluorocarbon solvents. White light-emitting devices and multicolor imaging of perfluorocarbon nanodroplets in live cells demonstrate the practical utility of these molecules. + © 2023 Wiley-VCH GmbH. + + + + Kim + Younghun + Y + + Seoul National University, Chemistry, KOREA, REPUBLIC OF. + + + + Kim + Heechan + H + + Seoul National University, Chemistry, KOREA, REPUBLIC OF. + + + + Son + Jung Bae + JB + + Seoul National University, Chemistry, KOREA, REPUBLIC OF. + + + + Filatov + Michael + M + + Kyungpook National University, Chemistry, KOREA, REPUBLIC OF. + + + + Choi + Cheol Ho + CH + + Kyungpook National University, Chemistry, KOREA, REPUBLIC OF. + + + + Lee + Nam Ki + NK + + Seoul National University, Chemistry, KOREA, REPUBLIC OF. + + + + Lee + Dongwhan + D + + Seoul National University, Department of Chemistry, Rm 503-524, Dept of Chemistry, SNU, Gwanak-ro 1, Gwanak-gu, 151-747, Seoul, KOREA, REPUBLIC OF. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Angew Chem Int Ed Engl + 0370543 + 1433-7851 + + IM + + Materials science + Photochemistry + aromaticity + fluorescence + hydrogen bonds + +
+ + + + 2023 + 03 + 14 + + + 2023 + 02 + 11 + + + 2023 + 03 + 14 + + + 2023 + 3 + 14 + 12 + 4 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917205 + 10.1002/anie.202302107 + + +
+ + + 36917209 + + 2023 + 03 + 14 + +
+ + 1463-9084 + + + 2023 + Mar + 14 + + + Physical chemistry chemical physics : PCCP + Phys Chem Chem Phys + + Localization of nuclear wave functions of lithium in [Li+@C60]PF6-: molecular insights into two-site disorder-order transition. + 10.1039/d2cp05835a + + Lithium endohedral fullerene, Li+@C60, is a porous system ideal for studying the quantized translational motion of the Li+ nucleus under subnanoscale confinement. The quantized nuclear motion strongly depends on the anharmonic and polarizable adsorbent potential within the C60 cage, which can be perturbed by cage distortion and/or exterior ions. In our recent paper, H. Ando and Y. Nakao, Phys. Chem. Chem. Phys., 2021, 23, 9785-9803, we focused on a [Li+@C60]PF6- salt and theoretically investigated how the Li+ ion in each C60 cage is simultaneously localized at two equivalent disordered sites in 24 K < T ≪ 100 K. At 24 K, the salt exhibits a disorder-order transition, whereby every Li+ ion becomes mostly localized at one of the two disordered sites below that temperature. Herein we discuss the origin of this transition with special attention to the local structural distortion and intermolecular interactions. Using the Fourier grid Hamiltonian method and a model function that fits a post-Hartree-Fock potential energy surface, we obtained hundreds of low-energy nuclear wave functions of Li+ confined within the cage. The weak distortions of the C60 cage and the PF6- coordination sphere below 24 K and concurrent inversion-symmetry breaking affect intermolecular interactions, thus making the wave functions of the nuclear ground state and several low-energy excited states localized around the experimental high-occupancy disordered site. This demonstrates that the distortions correlate closely with the two-site disorder-order transition. Finally, we reveal that two absorption peaks in the terahertz frequency range show substantial blueshifts upon cooling below 24 K, which serve as fingerprints of the transition. + + + + Ando + Hideo + H + http://orcid.org/0000-0003-4062-4611 + + Faculty of Science, Yamagata University, 1-4-12 Kojirakawa-machi, Yamagata, Yamagata 990-8560, Japan. ando@sci.kj.yamagata-u.ac.jp. + + + + Nakao + Yoshihide + Y + + Faculty of Life Science, Kyushu Sangyo University, 2-3-1 Matsukadai, Higashi-ku, Fukuoka 813-8503, Japan. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + England + Phys Chem Chem Phys + 100888160 + 1463-9076 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 4 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917209 + 10.1039/d2cp05835a + + +
+ + + 36917204 + + 2023 + 03 + 14 + +
+ + 1432-2129 + + + 2023 + Mar + 14 + + + Schmerz (Berlin, Germany) + Schmerz + + [Metaphors at the end of life: Resilience as resistance or acceptance]. + 10.1007/s00482-023-00702-z + + The article provides an overview of the research project "Metaphor in end-of-life care", which was conducted at Lancaster University (UK) between 2011 and 2014. The goals of the project were to show a) how patients, family members and healthcare professionals use metaphors to talk about their experiences with and expectations of end-of-life care, b) what experiences and needs are suggested by the use of metaphors by these groups and c) what contribution the results can make to communication in the healthcare system. A corpus consisting of interviews with the various groups of people and their postings in online fora were subject to both manual and semi-automated analyses. The results show that especially the online communications by patients and family members are characterized by violence and journey metaphors. The use of metaphors by these groups suggests a need for solidarity and community and reflects both positive and negative personal experiences. Resilience can be understood as resistance against illness or as acceptance of it. + © 2023. The Author(s). + + + + Koller + Veronika + V + + Department of Linguistics and English Language, Lancaster University, LA1 4YL, Lancaster, Großbritannien. v.koller@lancaster.ac.uk. + + + + ger + + English Abstract + Journal Article + Review + + Metaphern am Lebensende: Resilienz als Widerstand oder Akzeptanz. + + 2023 + 03 + 14 + +
+ + Germany + Schmerz + 8906258 + 0932-433X + + IM + + Der Beitrag bietet eine Übersicht über das Forschungsprojekt „Metaphern in der Betreuung am Lebensende“, das von 2011 bis 2014 an der Universität Lancaster in Großbritannien durchgeführt wurde. Zielsetzung des Projekts war es zu zeigen, a) wie Patient*innen, Familienangehörige und Gesundheitspersonal Metaphern verwenden, um über ihre Erfahrungen mit und Erwartungen an Betreuung am Lebensende zu sprechen, b) auf welche Erfahrungen und Bedürfnisse dieser Metapherngebrauch hindeutet und c) welchen Beitrag zur Kommunikation im Gesundheitswesen die Ergebnisse leisten können. Ein Korpus, bestehend aus Interviews mit verschiedenen Personengruppen und deren Beiträgen in Internetforen, wurde manuellen und halbautomatischen Analysen unterzogen. Die Ergebnisse zeigen, dass insbesondere die Onlinekommunikation von Patient*innen und Familienangehörigen von Gewalt- und Reisemetaphern geprägt ist. Der Metapherngebrauch dieser Gruppen deutet auf ein Bedürfnis nach Solidarität und Gemeinschaft hin und reflektiert sowohl positive als auch negative Selbsterfahrungen. Resilienz kann als Widerstand gegen Krankheit oder als deren Akzeptanz verstanden werden. + + + Empowerment + End-of-life care + Family members/communication + Healthcare professionals/communication + Patients/communication + +
+ + + + 2023 + 02 + 02 + + + 2023 + 3 + 14 + 12 + 4 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917204 + 10.1007/s00482-023-00702-z + 10.1007/s00482-023-00702-z + + + Literatur + + Bonhoeffer D, Bethge E (1985) Widerstand und Ergebung: Briefe und Aufzeichnungen aus der Haft. Siebenstern-Taschenbuch + + + Bullo S, Hearn JH (2021) Parallel worlds and personified pain: A mixed-methods analysis of pain metaphor use by women with endometriosis. Br J Health Psychol 26(2):271–288 + + 10.1111/bjhp.12472 + 32920887 + + + + Demjén Z, Semino E (2017) Using metaphor in healthcare: physical health. In: Semino E, Demjén Z (Hrsg) The Routledge handbook of metaphor and language. Routledge, Abingdon, S 385–399 + + + Department of Health (2007) Cancer reform strategy. www.nhs.uk/NHSEngland/NSF/Documents/Cancer%20Reform%20Strategy.pdf . Zugegriffen: 1. Okt. 2022 + + + Gabriel T (2005) Resilienz: Kritik und Perspektiven. Z Padagog 51:207–217 + + + Granger K (2014) Having cancer is not a fight or a battle. The Guardian, 25. April. http://www.theguardian.com/society/2014/apr/25/having-cancer-not-fight-or-battle . Zugegriffen: 2. Okt. 2022 + + + Hansen PK (2018) Illness and heroics: On counter-narrative and counter-metaphor in the discourse on cancer. Front Narrat Stud 4(s1):s213–s228 + + 10.1515/fns-2018-0039 + + + + Hommerberg C, Gustafsson AW, Sandgren A (2020) Battle, journey, imprisonment and burden: patterns of metaphor use in blogs about living with advanced cancer. BMC Palliat Care 19(1):1–10 + + 10.1186/s12904-020-00557-6 + + + + Pragglejaz Group (2007) MIP: A method for identifying metaphorically used words in discourse. Metaphor Symb 22(1):1–39 + + 10.1080/10926480709336752 + + + + Rayson P (2008) From key words to key semantic domains. Int J Corpus Linguist 13:519–549 + + 10.1075/ijcl.13.4.06ray + + + + Ruhwinkel B, Buchmann M (2022) Resilienz, ein Modewort? Praxis 111(14):793–796 + + 10.1024/1661-8157/a003920 + 36285408 + + + + Semino E (2018) Metaphor in discourse. Cambridge University Press, Cambridge + + + Semino E, Demjén Z, Hardie A, Payne S, Rayson P (2017) Metaphor, cancer and the end of life. Routledge, Abingdon + + 10.4324/9781315629834 + + + + Sontag S (1991) Illness as Metaphor and AIDS and Its Metaphors. Penguin, London + + + Vogt M, Schneider M (2016) Zauberwort Resilienz: Analysen zum interdisziplinären Gehalt eines schillernden Begriffs. Münchener Theol Z 67(3):180–194 (S 182) + + + +
+ + + 36917211 + + 2023 + 03 + 14 + +
+ + 1477-9137 + + 136 + 5 + + 2023 + Mar + 01 + + + Journal of cell science + J Cell Sci + + The cell biology of motors. + jcs261056 + 10.1242/jcs.261056 + + + Straube + Anne + A + 0000-0003-2067-9041 + + Warwick Medical School and Centre for Mechanochemical Cell Biology, University of Warwick, Gibbet Hill, Coventry, CV4 7AL, UK. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + England + J Cell Sci + 0052457 + 0021-9533 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 4 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + ppublish + + 36917211 + 297105 + 10.1242/jcs.261056 + + +
+ + + 36917210 + + 2023 + 03 + 14 + +
+ + 1097-0355 + + + 2023 + Mar + 14 + + + Infant mental health journal + Infant Ment Health J + + Reframing caring for parents who struggle with substance-use disorders. + 10.1002/imhj.22052 + + Nancy Suchman and the colleagues she influenced have produced ground-breaking and attitude-challenging work in understanding how parenting and substance use come together. Dr Suchman and her colleagues make the claim that there is nothing about a substance-use disorder that precludes effective and sensitive caring for children especially with interventions that focus on the parent-child relationship. Suchman's legacy is to highlight how substance use as an illness pulls individuals away from important, caring relationships and limits their giving themselves to those relationships. Restoring the salience of caring relationships and of the individual's ability to care may be as impactful on their substance use as a strict focus on the reduction of drug use and achieving abstinence. + © 2023 Michigan Association for Infant Mental Health. + + + + Mayes + Linda C + LC + https://orcid.org/0000-0002-9590-7128 + + Yale Child Study Center, Yale School of Medicine, New Haven, Connecticut, USA. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Infant Ment Health J + 8007859 + 0163-9641 + + IM + + attitudes + bias + early adversity + intergenerational + parenting + parents + substance misuse + +
+ + + + 2023 + 02 + 17 + + + 2023 + 02 + 17 + + + 2023 + 3 + 14 + 12 + 4 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917210 + 10.1002/imhj.22052 + + + REFERENCES + + 21st Century Cures Act. (2016). https://www.cancer.gov/research/key-initiatives/moonshot-cancer-initiative/about + + + Bartlett, J. D., Kotake, C., Fauth, R., & Easterbrooks, M. A. (2017). Intergenerational transmission of child abuse and neglect: Do maltreatment type, perpetrator, and substantiation status matter? Child Abuse & Neglect, 63, 84-94. + + + Borelli, J. L., Kazmierski, K. F. M., Gaskin, G. E., Kerr, M. L., Smiley, P. A., & Rasmussen, H. F. (in press). Savoring interventions for mothers of young children: Mechanisms linking relational savoring and personal savoring to reflective functioning. Infant Mental Health Journal. + + + Carlone, C., Milan, S., DeCoste, C., Borelli, J. L., McMahon, T. J., & Suchman, N. E. (in press). 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(2001). Cross-cultural views on stigma valuation parity and societal attitudes towards disability. In T. B. Üstün, S. Chatterji, J. E. Bickenbach, R. T. Trotter II, R. Room, & J. Rehm (Eds.), Disability and culture: Universalism and diversity (1st ed., pp. 247-291). Hogrefe & Huber Publishers. + + + Sinha, R. (2009). Modeling stress and drug craving in the laboratory: Implications for addiction treatment development. Addiction Biology, 14(1), 84-98. + + + Sinha, R., Shaham, Y., & Heilig, M. (2011). Translational and reverse translational research on the role of stress in drug craving and relapse. Psychopharmacology, 218, 69-82. + + + Smith, V. C., Wilson, C. R., Committee on Substance Use and Prevention, Ryan, S. A., Gonzalez, P. K., Patrick, S. W., Quigley, J., Siqueira, L., & Walker, L. R. (2016). Families affected by parental substance use. Pediatrics, 138(2), e20161575. https://doi.org/10.1542/peds.2016-1575 + + + Sontag, S. (1978). Illness as metaphor. Farrar, Straus and Giroux. + + + Strüber, N., Strüber, D., & Roth, G. (2014). Impact of early adversity on glucocorticoid regulation and later mental disorders. Neuroscience & Biobehavioral Reviews, 38, 17-37. + + + Yang, L. H., Wong, L. Y., Grivel, M. M., & Hasin, D. S. (2017). Stigma and substance use disorders: An international phenomenon. Current Opinion in Psychiatry, 30(5), 378-388. + + + +
+ + + 36917208 + + 2023 + 03 + 14 + +
+ + 1520-5851 + + + 2023 + Mar + 14 + + + Environmental science & technology + Environ Sci Technol + + Private and External Costs and Benefits of Replacing High-Emitting Peaker Plants with Batteries. + 10.1021/acs.est.2c09319 + + Falling costs of lithium-ion (Li-ion) batteries have made them attractive for grid-scale energy storage applications. Energy storage will become increasingly important as intermittent renewable generation and more frequent extreme weather events put stress on the electricity grid. Environmental groups across the United States are advocating for the replacement of the highest-emitting power plants, which run only at times of peak demand, with Li-ion battery systems. We analyze the life-cycle cost, climate, and human health impacts of replacing the 19 highest-emitting peaker plants in California with Li-ion battery energy storage systems (BESS). Our results show that designing Li-ion BESS to replace peaker plants puts them at an economic disadvantage, even if facilities are only sized to meet 95% of the original plants' load events and are free to engage in arbitrage. However, five of 19 potential replacements do achieve a positive net present value after including monetized climate and human health impacts. These BESS cycle far less than typical front-of-the-meter batteries and rely on the frequency regulation market for most of their revenue. All projects offer net air pollution benefits but increase net greenhouse gas emissions due to electricity demand during charging and upstream emissions from battery manufacturing. + + + + Porzio + Jason + J + + Energy Analysis and Environmental Impacts Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States. + + + Energy and Biosciences Institute, University of California, Berkeley, Berkeley, California 94720, United States. + + + Civil and Environmental Engineering Department, University of California, Berkeley, Berkeley, California 94720, United States. + + + + Wolfson + Derek + D + + Department of Agricultural and Resource Economics, University of California, Berkeley, Berkeley, California 94720, United States. + + + + Auffhammer + Maximilian + M + + Energy Analysis and Environmental Impacts Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States. + + + Department of Agricultural and Resource Economics, University of California, Berkeley, Berkeley, California 94720, United States. + + + National Bureau of Economic Research, Cambridge, Massachusetts 02138, United States. + + + + Scown + Corinne D + CD + 0000-0003-2078-1126 + + Energy Analysis and Environmental Impacts Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States. + + + Energy and Biosciences Institute, University of California, Berkeley, Berkeley, California 94720, United States. + + + Life Cycle, Economics and Agronomy Division, Joint BioEnergy Institute, Emeryville, California 94608, United States. + + + Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720 United States. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Environ Sci Technol + 0213155 + 0013-936X + + IM + + Li-ion batteries + air pollution + electricity grid + human health + life-cycle assessment + +
+ + + + 2023 + 3 + 14 + 12 + 4 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917208 + 10.1021/acs.est.2c09319 + + +
+ + + 36917214 + + 2023 + 03 + 14 + +
+ + 1531-6971 + + + 2023 + Mar + 15 + + + Current opinion in pulmonary medicine + Curr Opin Pulm Med + + The prevalence of childhood asthma: interpreting falling rates in the context of shifting measurement and the COVID-19 pandemic. + 10.1097/MCP.0000000000000959 + + The estimated prevalence of childhood asthma in the United States, as measured by the National Health Information Survey (NHIS), has decreased by 30% since 2017. This review provides context for observed changes in asthma rates by describing recent shifts in NHIS data collection and analysis, and considers whether the COVID-19 pandemic might impact asthma prevalence in years to come. + The NHIS underwent a planned redesign in 2019 with updated sampling weights to better match the U.S. population. In early 2020, the COVID-19 pandemic resulted in unplanned modifications to NHIS implementation, which may have included fewer children from populations at a heightened risk for asthma. Decreasing prevalence estimates in recent years are likely at least in part due to these survey changes rather than true epidemiologic shift. However, pandemic-related changes to risk factors for childhood asthma (including exposure to rhinovirus infections and allergic sensitization) may also influence prevalence in the future. + Recent changes in estimated rates of childhood asthma in the USA are likely driven by changes to survey methods and implementation, both before and during the COVID-19 pandemic. Additional years of data are needed to determine whether a true shift in disease prevalence is occurring. + Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved. + + + + Frey + Sean M + SM + + University of Rochester School of Medicine and Dentistry, Rochester, New York, USA. + + + + Rowe + Regina K + RK + + + Halterman + Jill S + JS + + + eng + + Journal Article + + + 2023 + 03 + 15 + +
+ + United States + Curr Opin Pulm Med + 9503765 + 1070-5287 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 12 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917214 + 10.1097/MCP.0000000000000959 + 00063198-990000000-00063 + + + + Akinbami LJ, Simon AE, Rossen LM. Changing trends in asthma prevalence among children. Pediatrics 2016; 137:1–7. + + + Centers for Disease Control and Prevention. 2017 Archived National Asthma Data. [Internet] 2017. https://www.cdc.gov/asthma/archivedata/2017/2017_archived_national_data.html. [Accessed 27 December 2022]. + + + Centers for Disease Control and Prevention. 2018 Archived National Asthma Data. [Internet] 2018. https://www.cdc.gov/asthma/archivedata/2018/2018_archived_national_data.html. + + + Centers for Disease Control and Prevention. 2019 Archived National Asthma Data. [Internet] 2019. https://www.cdc.gov/asthma/archivedata/2019/2019_archived_national_data.html. [Accessed 27 December 2022]. + + + Centers for Disease Control and Prevention. Most recent National Asthma Data. [internet] 2020. https://www.cdc.gov/asthma/most_recent_national_asthma_data.htm. [Accessed 27 December 2022]. + + + Blewett LA, Rivera Drew JA, King ML, et al. IPUMS Health Surveys. 2019 NHIS Redesign. Minneapolis, MN. [Internet] 2022. https://nhis.ipums.org/nhis/userNotes_2019_NHIS_Redesign.shtml. [Accessed 27 December 2022]. + + + Czajka JL, Beyler A. Final Report Volume I: background paper, declining response rates in federal surveys: trends and implications. Washington, D.C.:U.S. Department of Health and Human Services, Office of the Assistant Secretary for Planning and Evaluation; 2017. + + + Blewett LA, Rivera Drew JA, King ML, et al. IPUMS Health Surveys. User notes - sampling weights. Minneapolis, MN. [Internet] 2022. https://nhis.ipums.org/nhis/userNotes_weights.shtml. [Accessed 27 December 2022]. + + + Centers for Disease Control and Prevention Measuring childhood asthma prevalence before and after the 1997 redesign of the National Health Information Survey: United States. 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The relationship between housing and asthma among school-age children: analysis of the 2015 American Housing Survey. Washington, D.C.: Urban Institute. [Internet] 2017. https://www.urban.org/sites/default/files/publication/93881/the-relationshi-between-housing-and-asthma_1.pdf. [Accessed 27 December 2022]. + + + Zablotsky B, Black LI. Concordance between survey reported childhood asthma and linked Medicaid administrative records. J Asthma 2019; 56:285–295. + + + Kenyon CC, Hill DA, Henrickson SE, et al. Initial effects of the COVID-19 pandemic on pediatric asthma emergency department utilization. J Allergy Clin Immunol Pract 2020; 8:2774–2776. e1. + + + Sayed S, Diwadkar AR, Dudley JW, et al. COVID-19 pandemic-related reductions in pediatric asthma exacerbations corresponded with an overall decrease in respiratory viral infections. J Allergy Clin Immunol Pract 2022; 10:91–99. + + + Cohen HA, Blau H, Hoshen M, et al. Seasonality of asthma: a retrospective population study. 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Optimum predictors of childhood asthma: persistent wheeze or the Asthma Predictive Index? J Allergy Clin Immunol 2014; 2:709–715. + + + Hurley S, Franklin R, McCallion N, et al. Allergy-related outcomes at 12 months in the CORAL birth cohort of Irish children born during the first COVID 19 lockdown. Pediat Allerg Imm-Uk 2022; 33: + + + Li Y, Hu H, Zhang T, et al. Increase in indoor inhalant allergen sensitivity during the COVID-19 pandemic in South China: a cross-sectional study from 2017 to 2020. J Asthma Allergy 2021; 14:1185–1195. + + + Gillum LA, Gouveia C, Dorsey ER, et al. NIH disease funding levels and burden of disease. PLoS One 2011; 6:e16837. + + + Rui P, Kang K. National hospital ambulatory medical care survey: 2015 emergency department summary tables. [Internet] 2016. =https://www.cdc.gov/nchs/data/nhamcs/web_tables/2015_ed_web_tables.pdf. [Accessed 3 October 2022]. + + + Most recent asthma data. [Internet]. Atlanta: Centers for Disease Control and Prevention; 2016. https://www.cdc.gov/asthma/most_recent_data.htm. [Accessed 7 October 2022]. + + + Kenyon CC, Melvin PR, Chiang VW, et al. Rehospitalization for childhood asthma: timing, variation, and opportunities for intervention. J Pediatr 2014; 164:300–305. + + + Zipkin R, Schrager SM, Nguyen E, et al. Association between pediatric home management plan of care compliance and asthma readmission. J Asthma 2017; 54:761–767. + + + Alpern ER, Clark AE, Alessandrini EA, et al. Recurrent and gigh-frequency use of the emergency department by Pediatric PatientsRevisitas e Hiperfrecuentacion del Servicio de Urgencias por Pacientes Pediatricos. Acad Emerg Med 2014; 21:365–373. + + + Neuman MI, Alpern ER, Hall M, et al. Characteristics of recurrent utilization in pediatric emergency departments. Pediatrics 2014; 134:e1025–e1031. + + + Davis E, Fagnano M, Halterman JS, Frey SM. Utilization of the emergency department as a routine source of care among children with asthma. J Asthma 2022. 1–9. [Online ahead of print]. + + + Akinbami LJ, LaFleur BJ, Schoendorf KC. Racial and income disparities in childhood asthma in the United States. Ambul Pediatr 2002; 2:382–387. + + + Akinbami LJ, Moorman JE, Simon AE, Schoendorf KC. Trends in racial disparities for asthma outcomes among children 0 to 17 years, 2001–2010. J Allergy Clin Immunol 2014; 134:547–553. + + + Zhang Q, Lamichhane R, Diggs LA. Disparities in emergency department visits in American children with asthma: 2006–2010. J Asthma 2017; 54:679–686. + + + Crocker D, Brown C, Moolenaar R, et al. Racial and ethnic disparities in asthma medication usage and health-care utilization: data from the National Asthma Survey. Chest 2009; 136:1063–1071. + + + Oraka E, Iqbal S, Flanders WD, et al. Racial and ethnic disparities in current asthma and emergency department visits: findings from the national health interview survey, 2001–2010. J Asthma 2013; 50:488–496. + + + Martinez A, de la Rosa R, Mujahid M, Thakur N. Structural racism and its pathways to asthma and atopic dermatitis. J Allergy Clin Immunol 2021; 148:1112–1120. + + + Tyris J, Gourishankar A, Ward MC, et al. Social determinants of health and at-risk rates for pediatric asthma morbidity. Pediatrics 2022; 150: + + + Eguiliz-Gracia I, Mathioudakis AG, Bartel S, et al. The need for clean air: the way air pollution and climate change affect allergic rhinitis and asthma. Allergy 2020; 75:2170–2184. + + + +
+ + + 36917215 + + 2023 + 03 + 14 + +
+ + 1536-4844 + + + 2023 + Mar + 14 + + + Inflammatory bowel diseases + Inflamm Bowel Dis + + Proton pump Inhibitors and Risk of Enteric Infection in Inflammatory Bowel Disease: A Self-controlled Case Series. + izad035 + 10.1093/ibd/izad035 + + We tested whether proton pump inhibitors (PPIs) are associated with enteric infections among those with inflammatory bowel disease (IBD), after adequately accounting for baseline differences between PPI users and nonusers. + This was a self-controlled case series, with each patient serving as their own control. Ambulatory patients with IBD were included if they were tested for enteric infection by multiplex polymerase chain reaction testing panel (GIPCR) and/or Clostridoides difficile toxin PCR from 2015 to 2019 and received PPIs for some but not all of this period. Rates of enteric infections were compared between the PPI-exposed period vs pre- and post-PPI periods identical in duration to the exposed period. Conditional Poisson regression was used to adjust for time-varying factors. + Two hundred twenty-one IBD patients were included (49% ulcerative colitis, 46% Crohn's disease, and 5% indeterminate colitis). The median PPI duration was 7 months (interquartile range 4 to 11 months). A total of 25 (11%) patients had a positive GIPCR or C. difficile test in the PPI period, 9 (4%) in the pre-PPI period, and 8 (4%) in the post-PPI period. Observed incidence rates for enteric infections were 2.5, 7.4, and 2.2 per 100 person years for the pre-PPI, PPI, and post-PPI periods, respectively (adjusted incidence rate ratios, 2.8; 95% confidence interval [CI] 1.3-6.0) for PPI vs pre-PPI and 2.9 (95% CI, 1.3-6.4) for PPI vs post-PPI). The adjusted absolute excess risk associated with PPIs was 4.9 infections per 100 person years. + Proton pump inhibitors were associated with a 3-fold increased risk for enteric infection among those with IBD but had a modest absolute risk. + © The Author(s) 2023. Published by Oxford University Press on behalf of Crohn’s & Colitis Foundation. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. + + + + Varma + Sanskriti + S + 0000-0001-5179-7388 + + Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA. + + + + Trudeau + Stephen J + SJ + + Columbia Vagelos College of Physicians and Surgeons, New York, NY, USA. + + + + Li + Jianhua + J + + Biomedical Informatics, Columbia University Irving Medical Center, New York, NY, USA. + + + + Freedberg + Daniel E + DE + + Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA. + + + + eng + + + PR181960 + Department of Defense Clinical Trial Award + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + England + Inflamm Bowel Dis + 9508162 + 1078-0998 + + IM + + We tested whether proton pump inhibitors (PPIs) are associated with enteric infections among those with inflammatory bowel disease (IBD) by using a case-controlled series method, which allows for controlling of residual confounding. We studied ambulatory IBD patients who were tested for enteric infection from 2015 to 2019 and received PPIs for some of this period. Rates of enteric infections were compared between the PPI exposed period vs pre- and post-PPI periods identical in duration to the exposed period. We found that PPIs were associated with a 3-fold increased risk for enteric infection among those with IBD but had a modest absolute risk. + + + Clostridioides difficile + enteric infection + inflammatory bowel disease + proton pump inhibitors + +
+ + + + 2022 + 07 + 17 + + + 2023 + 3 + 14 + 12 + 12 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917215 + 7077422 + 10.1093/ibd/izad035 + + +
+ + + 36917212 + + 2023 + 03 + 14 + +
+ + 1477-9137 + + 136 + 5 + + 2023 + Mar + 01 + + + Journal of cell science + J Cell Sci + + Non-muscle myosin 2 at a glance. + jcs260890 + 10.1242/jcs.260890 + + Non-muscle myosin 2 (NM2) motors are the major contractile machines in most cell types. Unsurprisingly, these ubiquitously expressed actin-based motors power a plethora of subcellular, cellular and multicellular processes. In this Cell Science at a Glance article and the accompanying poster, we review the biochemical properties and mechanisms of regulation of this myosin. We highlight the central role of NM2 in multiple fundamental cellular processes, which include cell migration, cytokinesis, epithelial barrier function and tissue morphogenesis. In addition, we highlight recent studies using advanced imaging technologies that have revealed aspects of NM2 assembly hitherto inaccessible. This article will hopefully appeal to both cytoskeletal enthusiasts and investigators from outside the cytoskeleton field who have interests in one of the many basic cellular processes requiring actomyosin force production. + © 2023. Published by The Company of Biologists Ltd. + + + + Quintanilla + Melissa A + MA + + Department of Cell and Molecular Physiology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60525, USA. + + + + Hammer + John A + JA + + National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. + + + + Beach + Jordan R + JR + 0000-0003-0633-4928 + + Department of Cell and Molecular Physiology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60525, USA. + + + + eng + + + National Institute of General Medical Sciences + + + + R35GM138183 + National Institutes of Health + + + + DGE-1842190 + National Science Foundation + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + England + J Cell Sci + 0052457 + 0021-9533 + + IM + + Actin + Contractility + Myosin + + Competing interests The authors declare no competing or financial interests. +
+ + + + 2023 + 3 + 14 + 12 + 4 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + ppublish + + 36917212 + 297120 + 10.1242/jcs.260890 + + +
+ + + 36917218 + + 2023 + 03 + 14 + +
+ + 1536-4844 + + + 2023 + Mar + 14 + + + Inflammatory bowel diseases + Inflamm Bowel Dis + + Psychometric Performance of Fatigue Scales in Inflammatory Bowel Disease. + izad038 + 10.1093/ibd/izad038 + + Fatigue is highly prevalent in people with inflammatory bowel disease (IBD). Fatigue scales are important for studies testing fatigue interventions, but information about psychometric properties of many scales is insufficient in IBD. We compared the psychometric properties of multiple generic fatigue scales in participants with IBD. + Individuals with IBD (N = 216) completed the Daily Fatigue Impact Scale (DFIS), the vitality subscale of the RAND-36, and the Patient Health Questionnaire-9 (PHQ-9) fatigue item twice. A subgroup (n = 84) also completed the Fatigue Impact Scale (FIS) once, from which we also scored the 21 items from the Modified Fatigue Impact Scale (MFIS-IBD). We assessed floor/ceiling effects, construct validity, and internal consistency reliability. Using relative efficiency (RE), we compared discriminating ability and comparative responsiveness of the measures regarding disease activity and employment status and changes. + The FIS, MFIS, and RAND-36-vitality scales did not exhibit floor or ceiling effects. The DFIS showed mild floor effects (19.4%), and the PHQ-9 fatigue item showed floor (18.1%) and ceiling (20.8%) effects. Internal consistency reliability exceeded 0.93 for FIS, MFIS-IBD, and DFIS and was 0.81 for the RAND-36-vitality scale. In the subgroup analysis, the FIS, MFIS-IBD, and DFIS were strongly correlated with each other (r ≥ 0.90). The ability to discriminate between disease activity groups was highest for the FIS and MFIS-IBD, followed by the DFIS. The FIS, MFIS-IBD, and DFIS were responsive to changes in work impairment. + The FIS, MFIS-IBDs and DFIS had adequate validity and reliability for assessing fatigue in IBD. + © 2023 Crohn’s & Colitis Foundation. Published by Oxford University Press on behalf of Crohn’s & Colitis Foundation. + + + + Marrie + Ruth Ann + RA + 0000-0002-1855-5595 + + Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada. + + + Department of Community Health Sciences, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada. + + + + Fisk + John D + JD + + Nova Scotia Health Authority, Departments of Psychiatry, Psychology & Neuroscience, and Medicine, Dalhousie University, Halifax, Canada. + + + + Dolovich + Casandra + C + + Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada. + + + The University of Manitoba IBD Clinical and Research Centre, Max Rady College of Medicine Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada. + + + + Lix + Lisa M + LM + + Department of Community Health Sciences, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada. + + + The University of Manitoba IBD Clinical and Research Centre, Max Rady College of Medicine Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada. + + + + Graff + Lesley A + LA + + Nova Scotia Health Authority, Departments of Psychiatry, Psychology & Neuroscience, and Medicine, Dalhousie University, Halifax, Canada. + + + The University of Manitoba IBD Clinical and Research Centre, Max Rady College of Medicine Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada. + + + + Patten + Scott B + SB + 0000-0001-9871-4041 + + Departments of Community Health Sciences & Psychiatry, Cumming School of Medicine, University of Calgary, Calgary, Canada. + + + + Bernstein + Charles N + CN + + Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada. + + + The University of Manitoba IBD Clinical and Research Centre, Max Rady College of Medicine Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada. + + + + CIHR Team in Defining the Burden and Managing the Effects of Immune-mediated Inflammatory Disease + + + eng + + + THC-135234 + Canadian Institutes of Health Research + Canada + + + Crohn's and Colitis Canada + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + England + Inflamm Bowel Dis + 9508162 + 1078-0998 + + IM + + Fatigue is very common in people with inflammatory bowel disease (IBD). Fatigue scales are important for studies testing treatments for fatigue. However, information about how well these fatigue scales measure fatigue is inadequate in IBD. In this study, we compared the how well multiple fatigue scales worked in people with IBD. We focused on scales that can be used in many different clinical populations including the Fatigue Impact Scale (FIS), the Modified Fatigue Impact Scale-IBD (MFIS), the Daily Fatigue Impact Scale (DFIS), RAND-36-vitality scales and Patient Health Questionnaire fatigue item. Scores on the three FIS, MFIS and DFIS were strongly related to each other, and these three scales generally performed well; the others did not. The FIS and MFIS-IBD were best able to discrminate between people with IBD who did and did not have ongoing disease activity. + + + fatigue + inflammatory bowel disease + psychometrics + reliability + responsiveness + validity + +
+ + + + 2022 + 12 + 22 + + + 2023 + 3 + 14 + 12 + 12 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917218 + 7077424 + 10.1093/ibd/izad038 + + +
+ + + 36917216 + + 2023 + 03 + 14 + +
+ + 1531-6971 + + + 2023 + Mar + 15 + + + Current opinion in pulmonary medicine + Curr Opin Pulm Med + + Approach to the diagnosis of invasive fungal infections of the respiratory tract in the immunocompromised host. + 10.1097/MCP.0000000000000955 + + The burden of invasive fungal infection is increasing worldwide, largely due to a growing population at-risk. Most serious human fungal pathogens enter the host via the respiratory tract. Early identification and treatment of invasive fungal respiratory infections (IFRIs) in the immunocompromised host saves lives. However, their accurate diagnosis is a difficult challenge for clinicians and mortality remains high. + This article reviews IFRIs, focussing on host susceptibility factors, clinical presentation, and mycological diagnosis. Several new diagnostic tools are coming of age including molecular diagnostics and point-of-care antigen tests. As diagnosis of IFRI relies heavily on invasive procedures like bronchoalveolar lavage and lung biopsy, several novel noninvasive diagnostic techniques are in development, such as metagenomics, 'volatilomics' and advanced imaging technologies. + Where IFRI cannot be proven, clinicians must employ a 'weights-of-evidence' approach to evaluate host factors, clinical and mycological data. Implementation studies are needed to understand how new diagnostic tools can be best applied within clinical pathways. Differentiating invasive infection from colonization and identifying antifungal resistance remain key challenges. As our diagnostic arsenal expands, centralized clinical mycology laboratories and efforts to ensure access to new diagnostics in low-resource settings will become increasingly important. + Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved. + + + + Houston + Hamish + H + + Department of Clinical Microbiology, University College London Hospitals NHS Foundation Trust. + + + Institute for Health Informatics, University College London. + + + + Wilson + Andrew J + AJ + + Department of Clinical Haematology, University College London Hospitals NHS Foundation Trust, 250 Euston Road, London, UK. + + + + Stone + Neil + N + + Department of Clinical Microbiology, University College London Hospitals NHS Foundation Trust. + + + + eng + + Journal Article + + + 2023 + 03 + 15 + +
+ + United States + Curr Opin Pulm Med + 9503765 + 1070-5287 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 12 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917216 + 10.1097/MCP.0000000000000955 + 00063198-990000000-00062 + + + + Womiloju TO, Miller JD, Mayer PM, Brook JR. Methods to determine the biological composition of particulate matter collected from outdoor air. Atmos Environ 2003; 37:4335–4344. + + + Brown GD, Denning DW, Gow NA, et al. Hidden killers: human fungal infections. Sci Transl Med 2012; 4: 165rv13. + + + World Health Organization. WHO fungal priority pathogens list to guide research, development and public health action. Geneva: Licence: CC BY-NC-SA 3.0 IGO; 2022. + + + Fungal Disease Frequency: Global Action for Fungal Infections (GAFFI). 2022. Available at: https://gaffi.org/why/fungal-disease-frequency/ [cited 11th January 2023]. + + + WHO Technical Report Series N. 2021. The selection and use of essential in vitro diagnostics – TRS 1031. World Health Organization; 29 January 2021. Contract No.: Meeting report. + + + Casadevall A, Kontoyiannis Dimitrios P, Robert V. On the emergence of Candida auris: climate change, azoles, swamps, and birds. mBio 2019; 10:e01397–e1419. + + + Nnadi NE, Carter DA. Climate change and the emergence of fungal pathogens. PLoS Pathogens 2021; 17:e1009503. + + + Denning DW, Chakrabarti A. Pulmonary and sinus fungal diseases in nonimmunocompromised patients. Lancet Infect Dis 2017; 17:e357–e366. + + + Hong G. Progress and challenges in fungal lung disease in cystic fibrosis. Curr Opin Pulmon Med 2022; 28:584–590. + + + Tiew PY, Mac Aogáin M, Ter SK, et al. Respiratory mycoses in COPD and bronchiectasis. Mycopathologia 2021; 186:623–638. + + + Casadevall A. Immunity to invasive fungal diseases. Annu Rev Immunol 2022; 40:121–141. + + + Skipper CP, Hullsiek KH, Stadelman A, et al. Sterile cerebrospinal fluid culture at cryptococcal meningitis diagnosis is associated with high mortality. J Fungi 2022; 9:46. + + + Antachopoulos C. Invasive fungal infections in congenital immunodeficiencies. Clin Microbiol Infect 2010; 16:1335–1342. + + + Donnelly JP, Chen SC, Kauffman CA, et al. Revision and update of the consensus definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium. Clin Infect Dis 2020; 71:1367–1376. + + + Portugal RD, Garnica M, Nucci M. Index to predict invasive mold infection in high-risk neutropenic patients based on the area over the neutrophil curve. J Clin Oncol 2009; 27:3849–3854. + + + Lionakis MS, Kontoyiannis DP. Glucocorticoids and invasive fungal infections. Lancet 2003; 362:1828–1838. + + + Schmidt S, Hogardt M, Demir A, et al. Immunosuppressive compounds affect the fungal growth and viability of defined Aspergillus species. Pathogens 2019; 8:273. + + + Hoenigl M, Seidel D, Sprute R, et al. COVID-19-associated fungal infections. Nat Microbiol 2022; 7:1127–1140. + + + Kibbler CC, Barton R, Gow NAR, et al. Oxford texrbook of medical mycology. 2018; Oxford:Oxford University Press, xvii, 379 p,: illustrations. + + + Zarakas MA, Desai JV, Chamilos G, Lionakis MS. Fungal infections with ibrutinib and other small-molecule kinase inhibitors. Curr Fungal Infect Rep 2019; 13:86–98. + + + Chamilos G, Lionakis MS, Kontoyiannis DP. Call for action: invasive fungal infections associated with ibrutinib and other small molecule kinase inhibitors targeting immune signaling pathways. Clin Infect, Dis 2018; 66:140–148. 6 [1537–6591 (Electronic)]. + + + Setianingrum F, Rautemaa-Richardson R, Denning DW. Pulmonary cryptococcosis: a review of pathobiology and clinical aspects. Med Mycol 2019; 57:133–150. + + + Phoompoung P, Villalobos APC, Jain S, et al. Risk factors of invasive fungal infections in lung transplant recipients: a systematic review and meta-analysis. J Heart Lung Transplant 2022; 41:255–262. + + + Pérez-Jacoiste Asín MA, López-Medrano F, Fernández-Ruiz M, et al. Risk factors for the development of invasive aspergillosis after kidney transplantation: Systematic review and meta-analysis. Am J Transplant 2021; 21:703–716. + + + Alexander J, Limaye AP, Ko CW, et al. Association of hepatic iron overload with invasive fungal infection in liver transplant recipients. Liver Transplant 2006; 12:1799–1804. + + + Kontoyiannis P, Dimitrios, Marr A, et al. Prospective surveillance for invasive fungal infections in hematopoietic stem cell transplant recipients, 2001–2006: overview of the Transplant-Associated Infection Surveillance Network (TRANSNET) Database. Clin Infect Dis 2010; 50:1091–1100. + + + Kimura S-I, Tamaki M, Okinaka K, et al. Cytomegalovirus reactivation is associated with an increased risk of late-onset invasive aspergillosis independently of grade II–IV acute graft-versus-host disease in allogeneic hematopoietic stem cell transplantation: JSTCT Transplant Complications Worki. Ann Hematol 2021; 100:3029–3038. + + + Maertens JA. Carreras E, Dufour C, Mohty M, Kröger N. Invasive Fungal Infections. The EBMT handbook: hematopoietic stem cell transplantation and cellular therapies Springer, 7th ed Cham (CH):2019. + + + He R, Hu C, Niu R. Analysis of the clinical features of tracheobronchial fungal infections with tumor-like lesions. Respiration 2019; 98:157–164. + + + Corrêa LF, Fritscher CC, Fritscher RT, et al. Exclusively tracheobronchial paracoccidioidomycosis. Chest 2021; 160:e499–e501. + + + Samanta P, Clancy CJ, Nguyen MH. Fungal infections in lung transplantation. J Thorac Dis 2021; 13:6695–6707. + + + Stanzani M, Battista G, Sassi C, et al. Computed tomographic pulmonary angiography for diagnosis of invasive mold diseases in patients with hematological malignancies. Clin Infect Dis 2012; 54:610–616. + + + Godoy MCB, Ferreira Dalla Pria HR, Truong MT, et al. Invasive fungal pneumonia in immunocompromised patients. Radiol Clin North Am 2022; 60:497–506. + + + Apostolopoulou A, Fishman JA. The pathogenesis and diagnosis of Pneumocystis jiroveci pneumonia. J Fungi 2022; 8:1167. + + + Narayanasamy S, Dat VQ, Thanh NT, et al. A global call for talaromycosis to be recognised as a neglected tropical disease. Lancet Global Health 2021; 9:e1618–e1622. + + + Dingle TC, Croxen MA, Fathima S, et al. Histoplasmosis acquired in Alberta, Canada: an epidemiological and genomic study. Lancet Microbe 2021; 2:e191–e197. + + + Oladele RO, Ayanlowo OO, Richardson MD, Denning DW. Histoplasmosis in Africa: an emerging or a neglected disease? PLoS Negl Trop Dis 2018; 12:e0006046. + + + Allard-Chamard H, Alsufyani F, Kaneko N, et al. CD4+CTLs in fibrosing mediastinitis linked to Histoplasma capsulatum. J Immunol 2021; 206:524–530. + + + Bassetti M, Azoulay E, Kullberg B-J, et al. EORTC/MSGERC definitions of invasive fungal diseases: summary of activities of the intensive care unit working group. Clinical Infectious Diseases 2021; 72: (Suppl 2): S121–S127. + + + Barker KR, Kus JV, Normand AC, et al. A practical workflow for the identification of Aspergillus, Fusarium, Mucorales by MALDI-TOF MS: database, medium, and incubation optimization. J Clin Microbiol 2022; 60:e0103222. + + + Fontaine T, Latgé J-P. Galactomannan produced by Aspergillus fumigatus: an update on the structure, biosynthesis and biological functions of an emblematic fungal biomarker. J Fungi 2020; 6:283. + + + Leeflang MM, Debets-Ossenkopp YJ, Wang J, et al. Galactomannan detection for invasive aspergillosis in immunocompromised patients. Cochrane Database of Syst Rev 2015; 2017: + + + De Heer K, Gerritsen MG, Visser CE, Leeflang MM. Galactomannan detection in broncho-alveolar lavage fluid for invasive aspergillosis in immunocompromised patients. Cochrane Database of Syst Rev 2019; 2020: + + + Mercier T, Castagnola E, Marr KA, et al. Defining galactomannan positivity in the updated EORTC/MSGERC consensus definitions of invasive fungal diseases. Clin Infect Dis 2021; 72:S89–S94. + + + Del Corpo O, Butler-Laporte G, Sheppard DC, et al. Diagnostic accuracy of serum (1-3)-β-d-glucan for Pneumocystis jirovecii pneumonia: a systematic review and meta-analysis. Clin Microbiol Infect 2020; 26:1137–1143. + + + Lamoth F. Galactomannan and 1,3-β-d-glucan testing for the diagnosis of invasive Aspergillosis. J Fungi 2016; 2:22. + + + Angebault C, Lanternier F, Dalle F, et al. Prospective evaluation of serum β-glucan testing in patients with probable or proven fungal diseases. Open Forum Infect Dis 2016; 3:ofw128. + + + Lamoth F, Akan H, Andes D, et al. Assessment of the role of 1,3-β-d-glucan testing for the diagnosis of invasive fungal infections in adults. Clin Infect Dis 2021; 72:S102–S108. + + + Zeng H-Q, Zhang X-B, Cai X-Y, et al. Diagnostic value of bronchoalveolar lavage fluid cryptococcal antigen-lateral flow immunochromatographic assay for pulmonary cryptococcosis in non-HIV patients. Diagn Microbiol Infect Dis 2021; 99:115276. + + + Zhu N, Lin S, Weng X, et al. Performance of the colloidal gold immunochromatography of cryptococcal antigen on bronchoalveolar lavage fluid for the diagnosis of pulmonary cryptococcosis. Can J Infect Dis Med Microbiol 2022; 2022:1–7. + + + Cáceres DH, Gómez BL, Tobón ÁM, et al. Validation and concordance analysis of a new lateral flow assay for detection of histoplasma antigen in urine. J Fungi 2021; 7:799. + + + Martínez-Gamboa A, Niembro-Ortega MD, Torres-González P, et al. Diagnostic accuracy of antigen detection in urine and molecular assays testing in different clinical samples for the diagnosis of progressive disseminated histoplasmosis in patients living with HIV/AIDS: a prospective multicenter study in Mexico. PLoS Negl Trop Dis 2021; 15:e0009215. + + + Abdallah W, Myint T, LaRue R, et al. Diagnosis of histoplasmosis using the MVista. Open Forum Infect Dis 2021; 8:ofab454. + + + Donovan FM, Ramadan FA, Khan SA, et al. Comparison of a novel rapid lateral flow assay to enzyme immunoassay results for early diagnosis of Coccidioidomycosis. Clin Infect Dis 2021; 73:e2746–e2753. + + + Lockhart SR, Bialek R, Kibbler CC, et al. Molecular techniques for genus and species determination of fungi from fresh and paraffin-embedded formalin-fixed tissue in the revised EORTC/MSGERC definitions of invasive fungal infection. Clin Infect Dis 2021; 72:S109–S113. + + + Fisher BT, Boge CLK, Xiao R, et al. Multicenter prospective study of biomarkers for diagnosis of invasive candidiasis in children and adolescents. Clin Infect Dis 2022; 75:248–259. + + + Millon L, Caillot D, Berceanu A, et al. Evaluation of serum mucorales polymerase chain reaction (PCR) for the diagnosis of mucormycoses: the MODIMUCOR Prospective Trial. Clin Infect Dis 2022; 75:777–785. + + + Muthu V, Agarwal R, Patel A, et al. Definition, diagnosis, and management of COVID-19-associated pulmonary mucormycosis: Delphi consensus statement from the Fungal Infection Study Forum and Academy of Pulmonary Sciences, India. Lancet Infect Dis 2022; 22:e240–e253. + + + Jillwin J, Rudramurthy SM, Singh S, et al. Molecular identification of pathogenic fungi in formalin-fixed and paraffin-embedded tissues. J Med Microbiol 2021; 70:001282. + + + Perret T, Kritikos A, Hauser PM, et al. Ability of quantitative PCR to discriminate Pneumocystis jirovecii pneumonia from colonization. J Med Microbiol 2020; 69:705–711. + + + Jiang L, Gu R, Li X, Mu D. Simple and rapid detection Aspergillus fumigatus by loop-mediated isothermal amplification coupled with lateral flow biosensor assay. J Appl Microbiol 2021; 131:2351–2360. + + + Hoenigl M, Sprute R, Egger M, et al. The antifungal pipeline: fosmanogepix, ibrexafungerp, olorofim, opelconazole, and rezafungin. Drugs 2021; 81:1703–1729. + + + Harrison T, Partridge D. Should serum biomarker monitoring replace primary antifungal chemoprophylaxis in patients with acute leukaemia receiving systemic anticancer therapy? A PRO/CON debate. JAC Antimicrob Resist 2022; 4:dlac075. + + + Maertens J, Lodewyck T, Peter Donnelly J, et al. Empiric versus preemptive antifungal strategy in high-risk neutropenic patients on fluconazole prophylaxis: a randomized trial of the European Organization for Research and Treatment of cancer (EORTC 65091). doi:10.1093/cid/ciac623. (1537-6591.(Electronic)). + + + Biomarker Driven Antifungal Stewardship (BioDriveAFS) in acute leukaemia a multi-centre randomised controlled trial to assess clinical and cost effectiveness. (NIHR132674). NIHR Funding and Awards. Available at: https://www.fundingawards.nihr.ac.uk/award/NIHR132674. + + + Mercier T, Guldentops E, Lagrou K, Maertens J. Prospective evaluation of the turbidimetric β-d-glucan assay and 2 lateral flow assays on serum in invasive Aspergillosis. Clin Infect Dis 2021; 72:1577–1584. + + + Hill JA, Dalai SC, Hong DK, et al. Liquid biopsy for invasive mold infections in hematopoietic cell transplant recipients with pneumonia through next-generation sequencing of microbial cell-free DNA in plasma. Clin Infect Dis 2021; 73:e3876–e3883. + + + Ibrahim W, Wilde MJ, Cordell RL, et al. Visualization of exhaled breath metabolites reveals distinct diagnostic signatures for acute cardiorespiratory breathlessness. Sci Transl Med 2022; 14:eabl5849. + + + Ghosh C, Leon A, Koshy S, et al. Breath-based diagnosis of infectious diseases: a review of the current landscape. Clin Lab Med 2021; 41:185–202. + + + Angelini E, Shah A. Using artificial intelligence in fungal lung disease: CPA CT imaging as an example. Mycopathologia 2021; 186:733–737. + + + Diamant M, Baruch S, Kassem E, et al. A game theoretic approach reveals that discretizing clinical information can reduce antibiotic misuse. Nat Commun 2021; 12:1148. + + + Lawal IO, Mokoala KMG, Kgatle MM, et al. Radionuclide imaging of invasive fungal disease in immunocompromised hosts. Diagnostics 2021; 11:2057. + + + Lestrade PP, Bentvelsen RG, Schauwvlieghe AFAD, et al. Voriconazole resistance and mortality in invasive Aspergillosis: a multicenter retrospective cohort study. Clin Infect Dis 2019; 68:1463–1471. + + + Fisher MC, Alastruey-Izquierdo A, Berman J, et al. Tackling the emerging threat of antifungal resistance to human health. Nat Rev Microbiol 2022; 20:557–571. + + + Shelton JMG, Collins R, Uzzell CB, et al. Citizen science surveillance of triazole-resistant Aspergillus fumigatus in United Kingdom residential garden soils. Appl Environ Microbiol 2022; 88:e0206121. + + + Zhang SX, Babady NE, Hanson KE, et al. Recognition of diagnostic gaps for laboratory diagnosis of fungal diseases: expert opinion from the Fungal Diagnostics Laboratories Consortium (FDLC). J Clin Microbiol 2021; 59:e0178420. + + + Gow NAR, Johnson C, Berman J, et al. The importance of antimicrobial resistance in medical mycology. Nat Commun 2022; 13:5352. + + + +
+ + + 36917220 + + 2023 + 03 + 14 + +
+ + 1557-7740 + + + 2023 + Mar + 14 + + + Journal of palliative medicine + J Palliat Med + + Symptom Burden and Survival in Patients Receiving Outpatient and Home-Based Palliative Care. + 10.1089/jpm.2022.0267 + + Background: Symptom burden assessment with the Edmonton Symptom Assessment System (ESAS) has been widely studied among patients in outpatient palliative care (OPC), but fewer reports in home-based palliative care (HBPC), and none has assessed the prognostic value of ESAS scores in HBPC. Methods: This retrospective cohort study compares symptom burden and its prognostic value in adult patients receiving OPC and HBPC services between January 1, 2019, and June 30, 2021. Results: Patients completed the ESAS at the first OPC consultation (n = 4086) and at admission to HBPC (n = 4087). OPC patients were younger, more likely to have cancer, less likely to have had a recent hospitalization, and had higher adjusted median ESAS scores (28.1 vs. 22.9) compared with HBPC patients (all p < 0.001). ESAS was prognostic of survival in both settings (Hazard ratio 1.18-1.64, p < 0.01). Conclusion: Symptom burden is an independent prognosticator of survival in HBPC and OPC in this community-based setting. + + + + Haupt + Eric C + EC + + Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA. + + + + Sharma + Ishita + I + + Department of Geriatric, Palliative Medicine and Continuing Care, Kaiser-Downey Medical Center, Downey, California, USA. + + + + Nguyen + Huong Q + HQ + 0000-0002-3650-3705 + + Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + J Palliat Med + 9808462 + 1557-7740 + + IM + + home-based + outpatient + palliative care + real-world evidence + symptom burden + +
+ + + + 2023 + 3 + 14 + 12 + 13 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917220 + 10.1089/jpm.2022.0267 + + +
+ + + 36917219 + + 2023 + 03 + 14 + +
+ + 1531-6971 + + + 2023 + Mar + 15 + + + Current opinion in pulmonary medicine + Curr Opin Pulm Med + + Gram-negative pulmonary infections - advances in epidemiology and diagnosis. + 10.1097/MCP.0000000000000957 + + Pulmonary infections due to Gram-negative organisms are increasing worldwide and traditional assumptions that these are limited to hospital and ventilator-acquired pneumonia are rapidly falling away. Accordingly, empiric antibiotic guidelines have to follow suit with ever broader spectrum choices in order to remain 'safe', as the Global prevalence of extensively resistant Gram-negative organisms inexorably increases. Rapid, multiplex PCR-based detection of a wide variety of potential pathogens offers the opportunity to replace empiric antibiotic choices with targeted, evidence-based therapy in clinically actionable timeframes. + Here, we describe the data underpinning both the increasing global prevalence of Gram-negative pulmonary infections and their increasing antibiotic resistance. We also describe the performance, characteristics and early emerging clinical impact of already available rapid molecular diagnostic platforms and how they might best be deployed. + It seems will likely be advantageous to replace the current trend for empiric prescription of increasingly broad-spectrum antibiotics with 'same day' evidence-based, targeted therapy using high performance, rapid molecular diagnostic solutions. Several challenges remain be overcome, however, to fully realize their clear potential for better, focussed deployment of antibiotics, improved patient outcomes and antibiotic stewardship. + Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved. + + + + Radulescu + Mihaela + M + + Department of Microbiology, University College London Hospitals NHS Foundation Trust. + + + + Gant + Vanya + V + + Department of Microbiology, University College London Hospitals NHS Foundation Trust. + + + The Health Services Laboratories, The Halo Building, Mabledon Place, London, WC1H 9AX UK. + + + + eng + + Journal Article + + + 2023 + 03 + 15 + +
+ + United States + Curr Opin Pulm Med + 9503765 + 1070-5287 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 12 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917219 + 10.1097/MCP.0000000000000957 + 00063198-990000000-00061 + + + + GBD 2016 Lower Respiratory Infections Collaborators Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory infections in 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study. Lancet Infect Dis 2018; 18:1191–1210. + + + Rhee C, Jones TM, Hamad Y, et al. Prevalence, underlying causes, and preventability of sepsis-associated mortality in US acute care hospitals. JAMA Netw Open 2019; 2:e187571. + + + Metlay JP, Waterer GW, Long AC, et al. Diagnosis and treatment of adults with community-acquired pneumonia: an official clinical practice guideline of the American Thoracic Society and Infectious Diseases Society of America. Am J Respir Crit Care Med 2019; 200:e45–e67. + + + Kalil AC, Metersky ML, Klompas M, et al. Management of adults with hospital acquired and ventilator-associated pneumonia: 2016 clinical practice guidelines by the Infectious Diseases Society of America and the American Thoracic Society. Clin Infect Dis 2016; 63:e61–e111. + + + NICE 2019. Pneumonia in adults: diagnosis and management. Last updated: 16 September 2019 (reinstated 07 July 2022). www.nice.org.uk/guidance/cg191. [Accessed 09 November 2022]. + + + Shoar S, Musher DM. Etiology of community-acquired pneumonia in adults: a systematic review. Pneumonia 2020; 12:11. + + + Villafuerte D, Aliberti S, Soni NJ, et al. Prevalence and risk factors for Enterobacteriaceae in patients hospitalized with community-acquired pneumonia. Respirology 2020; 25:543–551. + + + Kishimbo P, Sogone NM, Kalokola F, Mshana SE. Prevalence of gram negative bacteria causing community acquired pneumonia among adults in Mwanza City, Tanzania. Pneumonia 2020; 12:1–9. + + + Ibrahim A. Bacterial etiology of community acquired pneumonia and their antimicrobial susceptibility in patients admitted to Alshaab Teaching Hospital. Sudan Med Lab J 2018; 6:78–94. + + + Assefa M, Tigabu A, Belachew T, Tessema B. Bacterial profile, antimicrobial susceptibility patterns, and associated factors of community acquired pneumonia among adult patients in Gondar, Northwest Ethiopia: a cross-sectional study. PLoS One 2022; 17:e0262956. + + + Jones RN. Microbial etiologies of hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia. Clin Infect Dis 2010; 51: (Suppl 1): S81–S87. + + + Poovieng J, Sakboonyarat B, Nasomsong W. Bacterial etiology and mortality rate in community-acquired pneumonia, healthcare-associated pneumonia and hospital-acquired pneumonia in Thai university hospital. Sci Rep 2022; 12:9004. + + + Dongol S, Kayastha G, Maharjan N, et al. Epidemiology, etiology, and diagnosis of healthcare acquired pneumonia including ventilator-associated pneumonia in Nepal. PLoS One 2021; 16:e0259634. + + + Feng DY, Zhou YQ, Zou XL, et al. Differences in microbial etiology between hospital-acquired pneumonia and ventilator-associated pneumonia: a single-center retrospective study in Guang Zhou. Infect Drug Resist 2019; 12:993–1000. + + + Sader HS, Castanheira M, Arends SJR, et al. Geographical and temporal variation in the frequency and antimicrobial susceptibility of bacteria isolated from patients hospitalized with bacterial pneumonia: results from 20 years of the SENTRY Antimicrobial Surveillance Program (1997–2016). J Antimicrob Chemother 2019; 74:1595–1606. + + + Antimicrobial Resistance Collaborators Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet 2022; 399:629–655. + + + Webb BJ, Dascomb K, Stenehjem E, Dean N. Predicting risk of drug-resistant organisms in pneumonia: moving beyond the HCAP model. Respir Med 2015; 109:1–10. + + + Hyun H, Song JY, Yoon JG, et al. Risk factor-based analysis of community-acquired pneumonia, healthcare-associated pneumonia and hospital-acquired pneumonia: microbiological distribution, antibiotic resistance, and clinical outcomes. PLoS One 2022; 17:e0270261. + + + Barreto JV, Dias CC, Cardoso T. Risk factors for community-onset pneumonia caused by drug-resistant pathogens: a prospective cohort study. Eur J Intern Med 2022; 96:66–73. + + + Blasi F, Garau J, Medina J, et al. Current management of patients hospitalized with community-acquired pneumonia across Europe: outcomes from REACH. Respir Res 2013; 14:44. + + + Naidus EL, Lasalvia MT, Marcantonio ER, Herzig SJ. The diagnostic yield of noninvasive microbiologic sputum sampling in a cohort of patients with clinically diagnosed hospital-acquired pneumonia. J Hosp Med 2018; 13:34–37. + + + Vaz AP, Amorim A, Espinar MJ, et al. Positive bronchoalveolar lavage and quantitative cultures results in suspected late-onset ventilator associated pneumonia evaluation: retrospective study. Rev Port Pneumol 2011; 17:117–123. + + + Klimko CV, Sanders JM, Monogue ML, et al. Bronchoalveolar lavage Gram stains for early bacterial identification in pneumonia: should they stay or should they go? Crit Care Explor 2021; 3 (8):e0501. + + + Jain S, Self WH, Wunderink RG, et al. Community-acquired pneumonia requiring hospitalization among U.S. adults. N Engl J Med 2015; 373:415–427. + + + BioFire Diagnostics 2022. The BioFire FilmArray Pneumonia (PN) Panel. https://www.biofiredx.com/products/the-filmarray-panels/filmarray-pneumonia/ [Accessed 12 November 2022] + + + Curetis GmbH, 2018 | Unyvero HPN Application Manual. https://curetis.com/resources/?resourcelib_category=ifu-manuals#r1. Last updated: 02/2018. [Accessed 12 November 2022] + + + Lee SH, Ruan SY, Pan SC, et al. Performance of a multiplex PCR pneumonia panel for the identification of respiratory pathogens and the main determinants of resistance from the lower respiratory tract specimens of adult patients in intensive care units. J Microbiol Immunol Infect 2019; 52:920–928. + + + Monard C, Pehlivan J, Auger G, et al. Multicenter evaluation of a syndromic rapid multiplex PCR test for early adaptation of antimicrobial therapy in adult patients with pneumonia. Crit Care 2020; 24:434. + + + Buchan BW, Windham S, Balada-Llasat JM, et al. Practical comparison of the BioFire FilmArray Pneumonia Panel to routine diagnostic methods and potential impact on antimicrobial stewardship in adult hospitalized patients with lower respiratory tract infections. J Clin Microbiol 2020; 58:e00135–e220. + + + Zacharioudakis IM, Zervou FN, Dubrovskaya Y, et al. Evaluation of a multiplex PCR panel for the microbiological diagnosis of pneumonia in hospitalized patients: experience from an Academic Medical Center. Int J Infect Dis 2021; 104:354–360. + + + Peiffer-Smadja N, Bouadma L, Mathy V, et al. Performance and impact of a multiplex PCR in ICU patients with ventilator-associated pneumonia or ventilated hospital-acquired pneumonia. Crit Care 2020; 24:366. + + + Poole S, Tanner AR, Naidu VV, et al. Molecular point-of-care testing for lower respiratory tract pathogens improves safe antibiotic de-escalation in patients with pneumonia in the ICU: results of a randomised controlled trial. J Infect 2022; 80:1–7. + + + Darie AM, Khanna N, Jahn K, et al. Fast multiplex bacterial PCR of bronchoalveolar lavage for antibiotic stewardship in hospitalised patients with pneumonia at risk of Gram-negative bacterial infection (Flagship II): a multicentre, randomised controlled trial. Lancet Respir Med 2022; 10:877–887. + + + Salina A, Schumann DM, Franchetti L, et al. Multiplex bacterial PCR in the bronchoalveolar lavage fluid of nonintubated patients with suspected pulmonary infection: a quasi-experimental study. ERJ Open Res 2022; 8:00595–2021. + + + Healthcare-associated infections in intensive care units - Annual Epidemiological Report for 2017. European Centre for Disease Prevention and Control. 2019. https://www.ecdc.europa.eu/sites/default/files/documents/AER_for_2017-HAI.pdf. [Accessed 12 November 2022] + + + Enne VI, Aydin A, Baldan R, et al. Multicentre evaluation of two multiplex PCR platforms for the rapid microbiological investigation of nosocomial pneumonia in UK ICUs: the INHALE WP1 study. Thorax 2022; 77:1220–1228. + + + Enne VI, Stirling S, Barber J, et al. INHALE WP3: Results of a multicentre randomised controlled trial (INHALE) testing the utility of rapid multiplex PCR at point-of-care for the antibiotic management of hospital-acquired and ventilator-associated pneumonia in critical care. IDWeek 2022: 19—23 October 2022; Washington, DC, USA. Conference proceedings in Open Forum Infectious Diseases (in press). + + + +
+ + + 36917221 + + 2023 + 03 + 14 + +
+ + 1538-9774 + + + 2023 + Mar + 13 + + + Computers, informatics, nursing : CIN + Comput Inform Nurs + + Usability Evaluation by Primary Care Providers of a Novel Digital Intervention for Type 2 Diabetes Self-Management in Older Adults. + 10.1097/CIN.0000000000001016 + + + Guerreiro + Mara Pereira + MP + + Author Affiliations: Nursing Research, Innovation and Development Centre of Lisbon (CIDNUR), Nursing School of Lisbon (Drs Guerreiro and Félix); Centro de Investigação Interdisciplinar Egas Moniz, Instituto Universitário Egas Moniz (Dr Guerreiro), Monte de Caparica; and LASIGE, Faculdade de Ciências, Universidade de Lisboa (Drs Balsa, Carmo, and Cláudio), Lisbon, Portugal. + + + + Balsa + João + J + + + Carmo + Maria Beatriz + MB + + + Cláudio + Ana Paula + AP + + + Félix + Isa Brito + IB + + + eng + + Journal Article + + + 2023 + 03 + 13 + +
+ + United States + Comput Inform Nurs + 101141667 + 1538-2931 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 13 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917221 + 10.1097/CIN.0000000000001016 + 00024665-990000000-00099 + + + + International Diabetes Federation. IDF Diabetes Atlas. 10th ed. Brussels, Belgium: International Diabetes Federation; 2021. www.diabetesatlas.org + + + Zheng Y, Ley SH, Hu FB. Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nature Reviews. Endocrinology. 2018;14(2): 88–98. doi:10.1038/nrendo.2017.151. + + 10.1038/nrendo.2017.151 + + + + Centers for Disease Control and Prevention. National Diabetes Statistics Report. Atlanta, GA: Centers for Disease Control and Prevention; 2020. + + + Shrivastava SR, Shrivastava PS, Ramasamy J. Role of self-care in management of diabetes mellitus. Journal of Diabetes and Metabolic Disorders. 2013;12(1): 14. doi:10.1186/2251-6581-12-14. + + 10.1186/2251-6581-12-14 + + + + World Health Organization. WHO Guideline Recommendations on Digital Interventions for Health System Strengthening. Geneva, Switzerland: World Health Organization; 2019. http://www.ncbi.nlm.nih.gov/pubmed/31162915 + + + Pal K, Eastwood SV, Michie S, et al. Computer-based diabetes self-management interventions for adults with type 2 diabetes mellitus. The Cochrane Database of Systematic Reviews. 2013;2013(3): CD008776. doi:10.1002/14651858.CD008776.pub2. + + 10.1002/14651858.CD008776.pub2 + + + + Bonoto BC, de Araújo VE, Godói IP, et al. Efficacy of mobile apps to support the care of patients with diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. JMIR mHealth and uHealth. 2017;5(3): e4. doi:10.2196/mhealth.6309. + + 10.2196/mhealth.6309 + + + + Cui M, Wu X, Mao J, Wang X, Nie M. T2DM self-management via smartphone applications: a systematic review and meta-analysis. 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The Behavior Change Wheel: A Guide To Designing Interventions. 1st ed. London, England: Silverback Publishing; 2014. + + + Arnhold M, Quade M, Kirch W. Mobile applications for diabetics: a systematic review and expert-based usability evaluation considering the special requirements of diabetes patients age 50 years or older. Journal of Medical Internet Research. 2014;16(4): e104. doi:10.2196/jmir.2968. + + 10.2196/jmir.2968 + + + + Guerreiro MP, Félix IB, Balsa J, et al. Contribution of an intelligent virtual assistant to healthy ageing in adults with type 2 diabetes. In: Mendes D, Fonseca C, Lopes MJ, García-Alonso J, Murillo JM, eds. Exploring the Role of ICTs in Healthy Aging. Hershey, PA: IGI Global; 2020:194–230. doi:10.4018/978-1-7998-1937-0.ch012 + + + Michie S, Richardson M, Johnston M, et al. The behavior change technique taxonomy (v1) of 93 hierarchically clustered techniques: building an international consensus for the reporting of behavior change interventions. 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International Journal of Care Coordination. 2017;20(1–2): 26–40. doi:10.1177/2053434517714427. + + 10.1177/2053434517714427 + + + + +
+ + + 36917217 + + 2023 + 03 + 14 + +
+ + 1420-908X + + + 2023 + Mar + 14 + + + Inflammation research : official journal of the European Histamine Research Society ... [et al.] + Inflamm Res + + Colchicine reduces the activation of NLRP3 inflammasome in COVID-19 patients. + 10.1007/s00011-023-01718-y + + To evaluate whether colchicine treatment was associated with the inhibition of NLRP3 inflammasome activation in patients with COVID-19. + We present a post hoc analysis from a double-blinded placebo-controlled randomized clinical trial (RCT) on the effect of colchicine for the treatment of COVID-19. Serum levels of NOD-like receptor protein 3 (NLRP3) inflammasome products-active caspase-1 (Casp1p20), IL-1β, and IL-18-were assessed at enrollment and after 48-72 h of treatment in patients receiving standard-of-care (SOC) plus placebo vs. those receiving SOC plus colchicine. The colchicine regimen was 0.5 mg tid for 5 days, followed by 0.5 mg bid for another 5 days. + Thirty-six patients received SOC plus colchicine, and thirty-six received SOC plus placebo. Colchicine reduced the need for supplemental oxygen and the length of hospitalization. On Days 2-3, colchicine lowered the serum levels of Casp1p20 and IL-18, but not IL-1β. + Treatment with colchicine inhibited the activation of the NLRP3 inflammasome, an event triggering the 'cytokine storm' in COVID-19. + RBR-8jyhxh. + © 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG. + + + + Amaral + N B + NB + + Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, 14.048-900, São Paulo, Brazil. + + + + Rodrigues + T S + TS + + Department of Cell Biology, University of São Paulo, Ribeirao Preto, São Paulo, Brazil. + + + + Giannini + M C + MC + + Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, 14.048-900, São Paulo, Brazil. + + + + Lopes + M I + MI + + Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, 14.048-900, São Paulo, Brazil. + + + + Bonjorno + L P + LP + + Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, 14.048-900, São Paulo, Brazil. + + + + Menezes + P I S O + PISO + + Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, 14.048-900, São Paulo, Brazil. + + + + Dib + S M + SM + + Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, 14.048-900, São Paulo, Brazil. + + + + Gigante + S L G + SLG + + Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, 14.048-900, São Paulo, Brazil. + + + + Benatti + M N + MN + + Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, 14.048-900, São Paulo, Brazil. + + + + Rezek + U C + UC + + Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, 14.048-900, São Paulo, Brazil. + + + + Emrich-Filho + L L + LL + + Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, 14.048-900, São Paulo, Brazil. + + + + Sousa + B A + BA + + Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, 14.048-900, São Paulo, Brazil. + + + + Almeida + S C L + SCL + + Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, 14.048-900, São Paulo, Brazil. + + + + Luppino-Assad + R + R + + Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, 14.048-900, São Paulo, Brazil. + + + + Veras + F P + FP + + Department of Pharmacology, University of São Paulo, Ribeirao Preto, São Paulo, Brazil. + + + + Schneider + A H + AH + + Department of Pharmacology, University of São Paulo, Ribeirao Preto, São Paulo, Brazil. + + + + Leiria + L O S + LOS + + Department of Pharmacology, University of São Paulo, Ribeirao Preto, São Paulo, Brazil. + + + + Cunha + L D + LD + + Department of Cell Biology, University of São Paulo, Ribeirao Preto, São Paulo, Brazil. + + + + Alves-Filho + J C + JC + + Department of Pharmacology, University of São Paulo, Ribeirao Preto, São Paulo, Brazil. + + + + Cunha + T M + TM + + Department of Pharmacology, University of São Paulo, Ribeirao Preto, São Paulo, Brazil. + + + + Arruda + E + E + + Department of Cell Biology, University of São Paulo, Ribeirao Preto, São Paulo, Brazil. + + + + Miranda + C H + CH + + Department of Emergency Medicine, University of São Paulo, Ribeirao Preto, São Paulo, Brazil. + + + + Pazin-Filho + A + A + + Department of Emergency Medicine, University of São Paulo, Ribeirao Preto, São Paulo, Brazil. + + + + Auxiliadora-Martins + M + M + + Department of Surgery and Anatomy, University of São Paulo, Ribeirao Preto, São Paulo, Brazil. + + + + Borges + M C + MC + + Department of Emergency Medicine, University of São Paulo, Ribeirao Preto, São Paulo, Brazil. + + + + Fonseca + B A L + BAL + + Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, 14.048-900, São Paulo, Brazil. + + + + Bollela + V R + VR + + Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, 14.048-900, São Paulo, Brazil. + + + + Del-Ben + C M + CM + + Department of Neuroscience and Behavior Ribeirao Preto Medical School, University of São Paulo, Ribeirao Preto, São Paulo, Brazil. + + + + Cunha + F Q + FQ + + Department of Pharmacology, University of São Paulo, Ribeirao Preto, São Paulo, Brazil. + + + + Santana + R C + RC + + Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, 14.048-900, São Paulo, Brazil. + + + + Vilar + F C + FC + + Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, 14.048-900, São Paulo, Brazil. + + + + Zamboni + D S + DS + + Department of Cell Biology, University of São Paulo, Ribeirao Preto, São Paulo, Brazil. + + + + Louzada-Junior + P + P + + Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, 14.048-900, São Paulo, Brazil. + + + + Oliveira + R D R + RDR + + Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, 14.048-900, São Paulo, Brazil. renedroliveira@gmail.com. + + + + eng + + + 2020/05288-6 + Fundação de Amparo à Pesquisa do Estado de São Paulo + + + + 2013/08216-2 + Fundação de Amparo à Pesquisa do Estado de São Paulo + + + + 2013/08216-2 + Fundação de Amparo à Pesquisa do Estado de São Paulo + + + + 2013/08216-2 + Fundação de Amparo à Pesquisa do Estado de São Paulo + + + + 2020/04964-8 + Fundação de Amparo à Pesquisa do Estado de São Paulo + + + + 2013/08216-2 + Fundação de Amparo à Pesquisa do Estado de São Paulo + + + + 2020/04826-4 + Fundação de Amparo à Pesquisa do Estado de São Paulo + + + + 425075/2016-8 + Conselho Nacional de Desenvolvimento Científico e Tecnológico + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + Switzerland + Inflamm Res + 9508160 + 1023-3830 + + IM + + COVID-19 + Colchicine + Cytokines + Inflammasome + +
+ + + + 2022 + 11 + 29 + + + 2023 + 03 + 06 + + + 2023 + 02 + 08 + + + 2023 + 3 + 14 + 12 + 12 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917217 + 10.1007/s00011-023-01718-y + 10.1007/s00011-023-01718-y + + + + Guan WJ, Ni ZY, Hu Y, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020;382:1708–20. + + 10.1056/NEJMoa2002032 + 32109013 + + + + Anka AU, Tahir MI, Abubakar SD, et al. Coronavirus disease 2019 (COVID-19): an overview of the immunopathology, serological diagnosis and management. Scand J Immunol. 2021;93: e12998. + + 10.1111/sji.12998 + 33190302 + + + + Del Valle DM, Kim-Schulze S, Huang HH, et al. An inflammatory cytokine signature predicts COVID-19 severity and survival. Nat Med. 2020;26:1636–43. + + 10.1038/s41591-020-1051-9 + 32839624 + 7869028 + + + + Rodrigues TS, de Sá KSG, Ishimoto AY, et al. Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients. J Exp Med. 2021;218: e20201707. + + 10.1084/jem.20201707 + 33231615 + + + + Toldo S, Bussani R, Nuzzi V, et al. Inflammasome formation in the lungs of patients with fatal COVID-19. Inflamm Res. 2021;70:7–10. + + 10.1007/s00011-020-01413-2 + 33079210 + + + + Liantinioti G, Argyris AA, Protogerou AD, Vlachoyiannopoulos P. The role of colchicine in the treatment of autoinflammatory diseases. Curr Pharm Des. 2018;24:690–4. + + 10.2174/1381612824666180116095658 + 29336247 + + + + Reyes AZ, Hu KA, Teperman J, et al. Anti-inflammatory therapy for COVID-19 infection: the case for colchicine. Ann Rheum Dis. 2021;80:550–7. + + 10.1136/annrheumdis-2020-219174 + 33293273 + + + + Lopes MI, Bonjorno LP, Giannini MC, et al. Beneficial effects of colchicine for moderate to severe COVID-19: a randomised, double-blinded, placebo-controlled clinical trial. RMD Open. 2021;7: e001455. + + 10.1136/rmdopen-2020-001455 + 33542047 + 7868202 + + + + Toro-Huamanchumo CJ, Benites-Meza JK, Mamani-García CS, et al. Efficacy of colchicine in the treatment of COVID-19 patients: a systematic review and meta-analysis. J Clin Med. 2022;11:2615. + + 10.3390/jcm11092615 + 35566737 + 9105993 + + + + Zein AFMZ, Raffaello WM. Effect of colchicine on mortality in patients with COVID-19—a systematic review and meta-analysis. Diabetes Metab Syndr. 2022;16: 102395. + + 10.1016/j.dsx.2022.102395 + 35078098 + 8752163 + + + + Lan SH, Hsu CK, Lai CC, et al. Effect of colchicine on the outcomes of patients with COVID-19: a systematic review and meta-analysis of randomised controlled trials. Ann Med. 2022;54:1956–65. + + 10.1080/07853890.2022.2096919 + 35833737 + 9291717 + + + + Lamontagne F, Agarwal A, Rochwerg B, et al. A living WHO guideline on drugs for covid-19. BMJ. 2020;370: m3379. + + 10.1136/bmj.m3379 + 32887691 + + + + Bartoletti M, Azap O, Barac A, et al. ESCMID COVID-19 living guidelines: drug treatment and clinical management. Clin Microbiol Infect. 2022;28:222–38. + + 10.1016/j.cmi.2021.11.007 + 34823008 + + + + Bartoletti M, Azap O, Barac A, et al. European society of clinical microbiology and infectious diseases guidelines for coronavirus disease 2019: an update on treatment of patients with mild/moderate disease. Clin Microbiol Infect. 2022;28:1578–90. + + 10.1016/j.cmi.2022.08.013 + 36028088 + 9398787 + + + + Jin Y-H, Cai L, Cheng Z-S, et al. A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version). Mil Med Res. 2020;7:4. + + 32029004 + 7003341 + + + + Bonaventura A, Vecchié A, Dagna L, Tangianu F, Abbate A, Dentali F. Colchicine for COVID-19: targeting NLRP3 inflammasome to blunt hyperinflammation. Inflamm Res. 2022;71:293–307. + + 10.1007/s00011-022-01540-y + 35113170 + 8811745 + + + + Tardif JC, Bouabdallaoui N, L’Allier PL, et al. Colchicine for community-treated patients with COVID-19 (COLCORONA): a phase 3, randomised, double-blinded, adaptive, placebo-controlled, multicentre trial. Lancet Respir Med. 2021;9:924–32. + + 10.1016/S2213-2600(21)00222-8 + 34051877 + 8159193 + + + + RECOVERY Collaborative Group. Colchicine in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. Lancet Respir Med. 2021;9:1419–26. + + 10.1016/S2213-2600(21)00435-5 + 8523117 + + + + Alfaidi M, Wilson H, Daigneault M, et al. Neutrophil elastase promotes interleukin-1β secretion from human coronary endothelium. J Biol Chem. 2015;290:24067–78. + + 10.1074/jbc.M115.659029 + 26269588 + 4591798 + + + + Dinarello CA. Interleukin-1. Cytokine Growth Factor Rev. 1997;8:253–65. + + 10.1016/S1359-6101(97)00023-3 + 9620641 + + + + Lachmann HJ, Lowe P, Felix SD, et al. In vivo regulation of interleukin 1beta in patients with cryopyrin-associated periodic syndromes. J Exp Med. 2009;206:1029–36. + + 10.1084/jem.20082481 + 19364880 + 2715040 + + + + Lopez-Castejon G, Brough D. Understanding the mechanism of IL-1β secretion. Cytokine Growth Factor Rev. 2011;22:189–95. + + 10.1016/j.cytogfr.2011.10.001 + 22019906 + 3714593 + + + + Silvis MJM, Fiolet ATL, Opstal TSJ, et al. Colchicine reduces extracellular vesicle NLRP3 inflammasome protein levels in chronic coronary disease: a LoDoCo2 biomarker substudy. Atherosclerosis. 2021;334:93–100. + + 10.1016/j.atherosclerosis.2021.08.005 + 34492522 + + + + Opstal TSJ, Hoogeveen RM, Fiolet ATL, et al. Colchicine attenuates inflammation beyond the inflammasome in chronic coronary artery disease: a LoDoCo2 proteomic substudy. Circulation. 2020;142(20):1996–8. + + 10.1161/CIRCULATIONAHA.120.050560 + 32864998 + + + + Vecchié A, Del Buono MG, Chiabrando GJ, Dentali F, Abbate A, Bonaventura A. Interleukin-1 and the NLRP3 inflammasome in pericardial disease. 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+ + + 36917222 + + 2023 + 03 + 14 + +
+ + 2731-7013 + + + 2023 + Mar + 14 + + + Dermatologie (Heidelberg, Germany) + Dermatologie (Heidelb) + + [The term mixed leg ulcer should no longer be used today]. + 10.1007/s00105-023-05129-2 + + A wound on the lower legs of patients with chronic venous insufficiency (CVI) and peripheral arterial disease (PAD) is today usually referred to as a mixed leg ulcer. This does not take into account the different stages of the diseases and, thus, their pathophysiological relevance. In everyday clinical practice, this often leads, among other things, to these patients not receiving compression therapy. The multidisciplinary professional association Initiative Chronische Wunden (ICW) e. V., therefore, recommends that this undifferentiated and misleading term should no longer be used. Instead, a leg ulcer with advanced CVI and concomitant PAD in stage I-IIb according to Fontaine or Rutherford category 0-3 should be classified as a venous leg ulcer, while a leg ulcer with advanced PAD in stage III or IV according to Fontaine or Rutherford category 4-6 and advanced CVI is termed an arteriovenous leg ulcer. A leg ulcer in advanced PAD stage IV according to Fontaine or Rutherford category 5 or 6 without advanced CVI is called an arterial leg ulcer. Other relevant comorbidities with an influence on wound healing should also be described separately. + © 2023. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature. + + + + Dissemond + J + J + + Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Essen, Hufelandstr. 55, 45122, Essen, Deutschland. joachim.dissemond@uk-essen.de. + + + + Bültemann + A + A + + + Gerber + V + V + + + Motzkus + M + M + + + Rembe + J-D + JD + + + Erfurt-Berge + C + C + + + ger + + English Abstract + Journal Article + Review + + Der Begriff Ulcus cruris mixtum sollte heute nicht mehr verwendet werden. + + 2023 + 03 + 14 + +
+ + Germany + Dermatologie (Heidelb) + 9918384885206676 + 2731-7005 + + IM + + Eine Wunde an den Unterschenkeln von Patienten mit chronischer venöser Insuffizienz (CVI) und peripherer arterieller Verschlusskrankheit (PAVK) wird heute meist als Ulcus cruris mixtum bezeichnet. Dabei werden die verschiedenen Stadien der Krankheitsbilder und somit deren pathophysiologische Relevanz nicht berücksichtigt. Im klinischen Alltag führt das u. a. oft dazu, dass diese Patienten keine Kompressionstherapie erhalten. Durch die multidisziplinäre Fachgesellschaft Initiative Chronische Wunden (ICW) e. V. wird daher empfohlen, diesen undifferenzierten und irreführenden Begriff nicht mehr zu verwenden. Stattdessen sollte ein Ulcus cruris bei fortgeschrittener CVI und begleitender PAVK im Stadium I–IIb nach Fontaine bzw. Rutherford Kategorie 0–3 als Ulcus cruris venosum; ein Ulcus cruris bei fortgeschrittener PAVK im Stadium III oder IV nach Fontaine bzw. Rutherford Kategorie 4–6 und fortgeschrittener CVI als arteriovenöses Ulcus cruris. Ein Ulcus cruris bei fortgeschrittener PAVK im Stadium IV nach Fontaine bzw. Rutherford Kategorie 5 oder 6 ohne fortgeschrittene CVI wird als Ulcus cruris arteriosum bezeichnet. Die relevanten weiteren Komorbiditäten mit Einfluss auf die Wundheilung sollten zudem separat beschrieben werden. + + + Arterial leg ulcer + Arteriovenous leg ulcer + Chronic wounds + Leg ulcer + Venous leg ulcer + +
+ + + + 2023 + 02 + 10 + + + 2023 + 3 + 14 + 12 + 13 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917222 + 10.1007/s00105-023-05129-2 + 10.1007/s00105-023-05129-2 + + + Literatur + + European Society for Vascular Surgery (ESVS), Björck M, Earnshaw JJ, Acosta S et al (2020) Clinical practice guidelines on the management of acute limb ischaemia. Eur J Vasc Endovasc Surg 59:173–218 + + + Dissemond J, Bültemann A, Gerber V, Jäger B, Kröger K, Münter C (2017) Diagnosis and treatment of chronic wounds: current standards of Germany’s Initiative for Chronic Wounds e. V. J Wound Care 26:727–732 + + 10.12968/jowc.2017.26.12.727 + 29244967 + + + + Dissemond J, Bültemann A, Gerber V, Jäger B, Münter C, Kröger K (2016) Definitionen für die Wundbehandlung. Hautarzt 67:265–266 + + 10.1007/s00105-016-3761-y + 26769313 + + + + Dissemond J, Bültemann A, Gerber V, Motzkus M, Rembe JD, Erfurt-Berge C (2022) Update der Standards der ICW e. V. für die Diagnostik und Therapie chronischer Wunden. Wundmanagement 16:274–280 + + + Dissemond J (2021) Modernes Wundmanagement chronischer Wunden. Hautarzt 72:733–744 + + 10.1007/s00105-021-04858-6 + 34283276 + + + + Eklöf B, Rutherford RB, Bergan JJ et al (2004) Revision of the CEAP classification for chronic venous disorders: consensus statement. J Vasc Surg 40:1248–1252 + + 10.1016/j.jvs.2004.09.027 + 15622385 + + + + Elhomsy S, Chrusciel J, Sanchez S, Elhomsy P, Guillaumat J (2021) Clinical efficacy and safety of long-term compression in patients with mixed arterial and venous etiology ulcers in the leg. Int J Angiol 31:34–39 + + 35221850 + 8881113 + + + + Körber A, Klode J, Al-Benna S et al (2011) Etiology of chronic leg ulcers in 31,619 patients in Germany analyzed by an expert survey. J Dtsch Dermatol Ges 9:116–121 + + 20946240 + + + + Lim SLX, Chung RE, Holloway S, Harding KG (2021) Modified compression therapy in mixed arterial-venous leg ulcers: an integrative review. Int Wound J 18:822–842 + + 10.1111/iwj.13585 + 33738975 + 8613381 + + + + Mosti G, Cavezzi A, Bastiani L, Partsch H (2020) Compression therapy is not contraindicated in diabetic patients with venous or mixed leg ulcer. J Clin Med 9:3709 + + 10.3390/jcm9113709 + 33227909 + 7699243 + + + + Mosti G, Iabichella ML, Partsch H (2012) Compression therapy in mixed ulcers increases venous output and arterial perfusion. J Vasc Surg 55:122–128 + + 10.1016/j.jvs.2011.07.071 + 21944912 + + + + Rabe E, Földi E, Gerlach H et al (2021) Medizinische Kompressionstherapie der Extremitäten mit medizinischem Kompressionsstrumpf (MKS), phlebologischem Kompressionsverband (PKV) und medizinischen adaptiven Kompressionssystemen (MAK): S2k-Leitlinie der Deutschen Gesellschaft für Phlebologie (DGP) in Kooperation mit folgenden Fachgesellschaften: DDG, DGA, DGG, GDL, DGL, BVP. Hautarzt 72:137–152 + + 10.1007/s00105-020-04734-9 + 33301064 + + + + Rabe E, Partsch H, Morrison N et al (2020) Risks and contraindications of medical compression treatment—A critical reappraisal. An international consensus statement. Phlebology 35:447–460 + + 10.1177/0268355520909066 + 32122269 + 7383414 + + + + Shi C, Dumville JC, Cullum N, Connaughton E, Norman G (2021) Compression bandages or stockings versus no compression for treating venous leg ulcers. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD013397.pub2 + + 10.1002/14651858.CD013397.pub2 + 34398473 + 8525070 + + + + Stansal A, Tella E, Yannoutsos A et al (2018) Supervised short-stretch compression therapy in mixed leg ulcers. J Med Vasc 43:225–230 + + 29981730 + + + + +
+ + + 36917224 + + 2023 + 03 + 14 + +
+ + 2731-703X + + + 2023 + Mar + 14 + + + Unfallchirurgie (Heidelberg, Germany) + Unfallchirurgie (Heidelb) + + [Psychotherapy prescribed by accident insurance consultants : Important component in treatment procedures of the statutory accident insurance]. + 10.1007/s00113-023-01313-0 + + In Germany around 1 Million working and commuting accidents per year are officially registered. Since several years this number is constantly at this high level, only just since the appearance of the actual Covid pandemia significantly lower because of lockdowns and increase of homeoffice workplaces. + To ensure the professional care of psychotraumatic sequelae of work-related injuries, in 2012 new regulations were introduced by the DGUV, the national umbrella organization of the German statutory health insurances. This healthcare reform (named "Psychotherapeutenverfahren", verbally translated: psychotherapists' procedure) is looked at 10 years later. Is the new regulation accepted by the surgeons' community? What case constellations can be observed? + The use of this new instrument among trauma surgeons was evaluated by national data for the complete years 2013-2021. Additionally, we include regional data and case reports from a multidisciplinary medical facility including trauma surgery and psychiatry, located in Güstrow (Northeast Germany). + Nationwide the percentage of psychotherapy amongst the regular treatment has doubled between 2013 and 2021 from 0.47 to 0.96%. + Looking at the first 10 years of its clinical implementation, the new German psychotherapy regulation is apparently well accepted by the accident insurance consultants. As data from population based studies are not available, the actual percentage of psychological sequelae of accidents in this cases is not known yet. So there is further need of research and training in this interdisciplinary field to ensure appropriate treatment of victims of work-related accidents. The integration of psychotraumatological facts in the educational agendas of accident insurance consultants has already started. + © 2023. The Author(s). + + + + Jugert + Josephine + J + + Klinik für Innere Medizin, KMG Klinikum Güstrow, Friedrich-Trendelenburg-Allee 1, 18273, Güstrow, Deutschland. josephine.jugert@t-online.de. + + + Institut für Arbeits‑, Sozial- und Umweltmedizin, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Deutschland. josephine.jugert@t-online.de. + + + + Schröder + Stefan G + SG + http://orcid.org/0000-0002-6508-1599 + + Klinik für Innere Medizin, KMG Klinikum Güstrow, Friedrich-Trendelenburg-Allee 1, 18273, Güstrow, Deutschland. doktorschroeder@gmx.de. + + + Klinik für Psychiatrie und Psychotherapie, KMG Klinikum Güstrow, Friedrich-Trendelenburg-Allee 1, 18273, Güstrow, Deutschland. doktorschroeder@gmx.de. + + + + Drechsel-Schlund + Claudia + C + + Berufsgenossenschaft für Gesundheitsdienst und Wohlfahrtspflege (BGW), Hamburg, Deutschland. claudia.drechsel-schlund@bgw-online.de. + + + + Angerer + Peter + P + + Institut für Arbeits‑, Sozial- und Umweltmedizin, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Deutschland. peter.angerer@uni-duesseldorf.de. + + + + ger + + English Abstract + Journal Article + + D-ärztlich veranlasste Psychotherapie : Wichtiger Baustein im Heilverfahren der gesetzlichen Unfallversicherung. + + 2023 + 03 + 14 + +
+ + Germany + Unfallchirurgie (Heidelb) + 9918384886306676 + 2731-7021 + + IM + + HINTERGRUND: Deutschlandweit liegt mit etwa 1 Mio. pro Jahr die Zahl von Arbeits- und Wegeunfällen seit Jahren konstant hoch, aktuell allerdings pandemiebedingt niedriger, aufgrund von partiellen Betriebsschließungen, Lockdown-Maßnahmen und der Zunahme von Arbeit aus dem „Homeoffice“. + Die Deutsche Gesetzliche Unfallversicherung e. V. (DGUV; gemeinsamer Spitzenverband der Unfallversicherungsträger) hat 2012 mit dem sog. Psychotherapeutenverfahren ein Instrument zur Förderung und zur Regulierung fachkundiger Versorgung psychischer Unfallfolgen geschaffen. Wie ist diese Regelung angenommen worden? Welche Fallkonstellationen werden beobachtet? + Nationale Daten zur Nutzung des Psychotherapeutenverfahrens bei Arbeits- und Wegeunfällen werden rückblickend für die Jahrgänge 2013–2021 vorgestellt, exemplarisch auch regionale, inklusive Fallskizzen (aus Güstrow). + Deutschlandweit hat sich im betrachteten Zeitraum der Prozentsatz der Psychotherapien von 0,47 auf 0,96 % verdoppelt. + Die 10-Jahresbilanz ist positiv, das Psychotherapeutenverfahren wird offensichtlich gut angenommen. Der tatsächliche Psychotherapiebedarf lässt sich nur aus Einzelstudien abschätzen, repräsentative Studien fehlen. Interdisziplinäres klinisches und wissenschaftliches Engagement für die Psychotraumatisierten ist notwendig und zu optimieren. Grundwissen in Psychotraumatologie ist daher bereits für die D‑Arzt-Medizin in den unfallchirurgischen Weiterbildungskatalog aufgenommen worden. + + + Posttraumatic stress disorder + Psychological sequelae of accidents + Psychotraumatology + Rehabilitation + Work-related injuries + +
+ + + + 2022 + 10 + 27 + + + 2023 + 3 + 14 + 12 + 13 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917224 + 10.1007/s00113-023-01313-0 + 10.1007/s00113-023-01313-0 + + + Literatur + + Adams DB (1992) The future roles for psychotherapy in the medical-surgical arena. Psychotherapy 29:95–103 + + 10.1037/0033-3204.29.1.95 + + + + Angenendt J (2021) Das weite Spektrum psychischer Unfallfolgen. Unfallchirurg 124:7–14 + + 10.1007/s00113-020-00935-y + 33330948 + + + + Angenendt J, Drechsel-Schlund C, Südkamp N et al (2016) Notfallmedizin und Unfallchirurgie: Psychotraumatologie nach Unfällen. Dtsch Arztebl 113(40):A1752–A1754 + + + Angenendt J, Hecht H, Nowotny-Behrens U et al (2006) Freiburger Arbeitsunfallstudie‑I (FAUST-I), Teil II: Wirksamkeit einer stationären psychologischen Frühintervention. Trauma Berufskrankh 8:74–79 + + 10.1007/s10039-006-1113-3 + + + + Angenendt J, Riering A, Röhrich B et al (2012) Freiburger Arbeitsunfallstudie-II (FAUST-II), Früherkennung, Diagnostik und Prävention psychischer Gesundheitsstörungen nach schweren Arbeitsunfällen: Auswirkungen auf die Rehabilitation. Trauma Berufskrankh 14:86–193 + + 10.1007/s10039-011-1790-4 + + + + Angenendt J, Röhrich B, Riering A et al (2011) Freiburger Arbeitsunfallstudie-II (FAUST-II), Screeninggestützte Früherkennung psychischer Gesundheitsstörungen nach schweren Arbeitsunfällen. Trauma Berufskrankh 13:56–64 + + 10.1007/s10039-010-1697-5 + + + + Arbeitsgemeinschaft der wissenschaftlichen Fachgesellschaften – AWMF (2019) S2k-Leitlinie Diagnostik und Behandlung von akuten Folgen psychischer Traumatisierung. www.awmf.org . Zugegriffen: 27. Juli 2022 + + + Boals A, Trost Z, Rainey E et al (2017) Severity of traumatic injuries predicting psychological outcomes: a surprising lack of empirical evidence. J Anxiety Disord 50:1–6 + + 10.1016/j.janxdis.2017.04.004 + 28501651 + + + + Brand S, Otte D, Petri M et al (2014) Incidence of posttraumatic stress disorder after traffic accidents in Germany. Int J Emerg Ment Health 16:233–236 + + 10.4172/1522-4821.1000109 + 25345235 + + + + Bryant RA, Nickerson A, Creamer M et al (2015) Trajectory of post-traumatic stress following traumatic injury: 6‑year follow-up. Br J Psychiatry 206:417–423 + + 10.1192/bjp.bp.114.145516 + 25657356 + + + + DGUV Psychotherapeutenverfahren, Informationen zur Zusammenarbeit für Durchgangsärztinnen und Durchgangsärzte. https://publikationen.dguv.de/widgets/pdf/download/article/3496 . Zugegriffen: 27. Juli 2022 + + + Drechsel-Schlund C, Ullmann U, Angenendt J (2018) Versorgungsstrukturen bei traumatischen Ereignissen am Arbeitsplatz. ASU 01-2018:20–27 + + + Drechsel-Schlund C, Weiß M, Krahl C et al (2015) Umsetzung des Psychotherapeutenverfahrens. Trauma Berufskrankh 17:275–280 + + 10.1007/s10039-015-0006-8 + + + + Gruner B, Drechsel-Schlund C (2022) Arbeitsunfälle und Berufskrankheit. Die psychosomatisch-psycho-therapeutische Arbeit im Rahmen des Psychotherapeutenverfahrens der DGUV. Ärztl Psychother 17(2):125–130 + + 10.21706/aep-17-2-125 + + + + MacDonald HA, Colotla V, Flamer S et al (2003) Posttraumatic stress disorder (PTSD) in the workplace: a descriptive study of workers experiencing PTSD resulting from work injury. J Occup Rehabil 13(2):63–77 + + 10.1023/A:1022563930482 + 12708101 + + + + Ozer EJ, Best SR, Lipsey TL et al (2003) Predictors of post-traumatic stress disorder and symptoms in adults: a meta-analysis. Psychol Bull 129:52–73 + + 10.1037/0033-2909.129.1.52 + 12555794 + + + + Schäfer I, Gast U, Hofmann A et al (2019) S3-Leitlinie Posttraumatische Belastungsstörung. Springer, Berlin ( www.awmf.org . Zuletzt abgerufen am 27.07.2022) + + 10.1007/978-3-662-59783-5 + + + + Skogstad M, Skorstad M, Lie A et al (2013) Work-related post-traumatic stress disorder. Occup Med 63(3):175–182 + + 10.1093/occmed/kqt003 + + + + Südkamp N, Angenendt J, Hecht H et al (2006) Freiburger Arbeitsunfallstudie (FAUST). Trauma Berufskrankh 8:67–73 + + 10.1007/s10039-006-1112-4 + + + + Tagay S, Repic N, Senf W (2013) Traumafolgestörungen bei Erwachsenen, Kindern und Jugendlichen. Psychotherapeut 58:44–55 + + 10.1007/s00278-011-0847-y + + + + Ullmann U (2021) Posttraumatische Belastungsstörung. Unfallchirurg 124:15–20 + + 10.1007/s00113-020-00930-3 + 33300092 + + + + Ullmann U, Krahl G, Krahl C et al (2016) Psychische Traumatisierungen nach Unfällen und Gewalterfahrungen – eine therapeutische Herausforderung. Orthop Unfallchir Mitt Nachr 05(01):86–87 + + 10.1055/s-0042-100146 + + + + Visser E, Gosens T, Den Oudsten BL et al (2017) The course, prediction and treatment of acute and post-traumatic stress in trauma patients: a systematic review. J Trauma 82:1158–1183 + + 10.1097/TA.0000000000001447 + + + + +
+ + + 36917223 + + 2023 + 03 + 14 + +
+ + 2731-703X + + + 2023 + Mar + 14 + + + Unfallchirurgie (Heidelberg, Germany) + Unfallchirurgie (Heidelb) + + [Trauma team activation-Who should be alerted for which patients?] + 10.1007/s00113-023-01306-z + + It is estimated that in total almost 10 million people are injured in accidents in Germany every year, most of which are in the household milieu and leisure sector. It is estimated that of these more than 32,000 seriously injured patients are admitted to the emergency room every year. It is recommended that the decision of the prehospital treatment team or the first examiner in the hospital as to whether a potentially severely injured patient should be admitted via the emergency room of the hospital should be based on a catalogue of criteria. + Against the background of the update of the S3 guidelines on the treatment of multiple trauma/severely injured patients and on the basis of the current literature, an overview with respect to the composition of the team and the criteria for which an emergency room team is or should be activated is given. + Alerting the emergency room team is still recommended if a certain injury pattern is present or if a prehospital intervention is necessary. The B‑criteria based on the course of the accident or mechanism, which have recently been the subject of increasing criticism, have been adapted. Recommendations for geriatric patients could also be formulated. + Compared to the S3 guidelines from 2016 the emergency room alarm criteria could be revised on the basis of new literature and have been included in the revised guidelines. There is no doubt that further optimization. e.g., based on prehospital algorithms or using point of care diagnostics, are possible and desirable in the future. + © 2023. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature. + + + + Bieler + D + D + + Klinik für Unfallchirurgie und Orthopädie, Wiederherstellungs- und Handchirurgie, Verbrennungsmedizin, Bundeswehrzentralkrankenhaus Koblenz, Rübenacher Straße 170, 56072, Koblenz, Deutschland. dan.bieler@uni-duesseldorf.de. + + + Klinik für Orthopädie und Unfallchirurgie, Universitätsklinikum Düsseldorf, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Deutschland. dan.bieler@uni-duesseldorf.de. + + + + Schweigkofler + U + U + + Unfallchirurgie und Orthopädische Chirurgie, BG Unfallklinik Frankfurt am Main gGmbH, Frankfurt am Main, Deutschland. + + + + Waydhas + C + C + + Klinik für Unfall‑, Hand- und Wiederherstellungschirurgie, Universitätsklinikum Essen, Essen, Deutschland. + + + + Wagner + F + F + + Septische und Rekonstruktive Chirurgie, Berufsgenossenschaftliche Unfallklinik Murnau, Murnau, Deutschland. + + + + Spering + C + C + + Klinik für Unfallchirurgie, Orthopädie und Plastische Chirurgie, Universitätsmedizin Göttingen, Göttingen, Deutschland. + + + + Kühne + C A + CA + + Klinik für Unfall- und Handchirurgie, Zentrum für Alterstraumatologie, Schön-Klinik Hamburg Eilbek, Hamburg, Deutschland. + + + + ger + + English Abstract + Journal Article + Review + + Schockraumaktivierung – Bei welchen Patienten alarmieren wir wen? + + 2023 + 03 + 14 + +
+ + Germany + Unfallchirurgie (Heidelb) + 9918384886306676 + 2731-7021 + + IM + + EINLEITUNG: Insgesamt gibt es in Deutschland jedes Jahr schätzungsweise fast 10 Mio. Unfallverletzte, wovon der größte Teil der Unfälle sich im Haushalts- und im Freizeitbereich ereignet. Jährlich werden schätzungsweise über 32.000 schwer verletzte Patienten über den Schockraum ins Krankenhaus aufgenommen. Es wird empfohlen, die Entscheidung des prähospitalen Behandlungsteams bzw. des Erstsichtenden in der Klinik, ob ein potenziell schwer verletzter Patient über den Schockraum aufgenommen werden sollte, anhand eines Kriterienkatalogs vorzunehmen. + Vor dem Hintergrund der Novellierung der S3-Leitlinie „Polytrauma/Schwerverletzten-Behandlung“ und auf Basis der aktuellen Literatur wird ein Überblick hinsichtlich der Teamzusammensetzung und über Kriterien, bei deren Vorliegen ein Schockraumteam aktiviert werden soll bzw. sollte, gegeben. + Nach wie vor wird die Alarmierung des Schockraumteams bei Vorliegen eines gewissen Verletzungsmusters bzw. notwendiger prähospitaler Intervention empfohlen. Die Schockraum-B-Kriterien, basierend auf Unfallhergang bzw. -mechanismus, die in letzter Zeit zunehmend in der Kritik standen, wurden angepasst. Es können auch Empfehlungen für geriatrische Patienten formuliert werden. + Im Vergleich zur S3-Leitlinie 2016 konnten die Schockraumalarmierungskriterien auf Basis neuer Literatur überarbeitet werden; diese Überarbeitung hat Eingang in die aktualisierte Leitlinie gefunden. Unzweifelhaft sind in Zukunft weitere Optimierungen – z. B. auf Basis prähospitaler Algorithmen unter Nutzung von Point-of-care-Diagnostik – möglich und wünschenswert. + + + Activation criteria + Guidelines + Medical emergency team + Multiple trauma + Triage + +
+ + + + 2023 + 02 + 09 + + + 2023 + 3 + 14 + 12 + 13 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917223 + 10.1007/s00113-023-01306-z + 10.1007/s00113-023-01306-z + + + Literatur + + Bieler D, Trentzsch H, Baacke M et al (2018) Optimization of criteria for activation of trauma teams : avoidance of overtriage and undertriage. Unfallchirurg 121:788–793 + + 10.1007/s00113-018-0553-0 + 30242444 + + + + Bieler D, Trentzsch H, Franke A et al (2021) Evaluation of a standardized instrument for post hoc analysis of trauma-team-activation-criteria in 75,613 injured patients an analysis of the TraumaRegister DGU(®).Eur J Trauma Emerg Surg. https://doi.org/10.1007/s00068-021-01668-2 + + + Bond RJ, Kortbeek JB, Preshaw RM (1997) Field trauma triage: combining mechanism of injury with the prehospital index for an improved trauma triage tool. J Trauma 43:283–287 + + 10.1097/00005373-199708000-00013 + 9291374 + + + + Bundesanstalt FüR Arbeitsschutz Und Arbeitsmedizin (Baua) RKI (2015) Unfallstatistik 2015 + + + Damme CD, Luo J, Buesing KL (2016) Isolated prehospital hypotension correlates with injury severity and outcomes in patients with trauma. Trauma Surg Acute Care Open 1:e13 + + 10.1136/tsaco-2016-000013 + 29766057 + 5891702 + + + + Debus F, Lefering R, Frink M et al (2015) Numbers of severely injured patients in Germany. A retrospective analysis from the DGU (German society for trauma surgery) trauma registry. Dtsch Arztebl Int 112:823–829 + + 26754119 + 4711294 + + + + Dehli T, Monsen SA, Fredriksen K et al (2016) Evaluation of a trauma team activation protocol revision: a prospective cohort study. Scand J Trauma Resusc Emerg Med 24:105 + + 10.1186/s13049-016-0295-3 + 27561336 + 5000402 + + + + Deutsche-Gesellschaft-Für-Unfallchirurgie (2019) Weißbuch Schwerverletztenversorgung + + + Deutsche-Gesellschaft-Für-Unfallchirurgie_E. V. (2022) S3-Leitlinie Polytrauma/Schwerverletzten-Behandlung (AWMF Registernummer 187-023). In: + + + Hagebusch P, Faul P, Klug A et al (2022) Elevated serum lactate levels and age are associated with an increased risk for severe injury in trauma team activation due to trauma mechanism. Eur J Trauma Emerg Surg 48:2717–2723 + + 10.1007/s00068-021-01811-z + 34734311 + + + + Hasler RM, Nuesch E, Juni P et al (2011) Systolic blood pressure below 110 mm Hg is associated with increased mortality in blunt major trauma patients: multicentre cohort study. Resuscitation 82:1202–1207 + + 10.1016/j.resuscitation.2011.04.021 + 21632168 + + + + Hasler RM, Nuesch E, Juni P et al (2012) Systolic blood pressure below 110 mm Hg is associated with increased mortality in penetrating major trauma patients: Multicentre cohort study. Resuscitation 83:476–481 + + 10.1016/j.resuscitation.2011.10.018 + 22056618 + + + + Heindl B, Trentzsch H, Flohé S (2021) Notfallinterventionsrate bei Schockraumpatienten in Abhängigkeit von den Alarmierungskriterien. Unfallchirurg 124:909–915 + + 10.1007/s00113-020-00948-7 + 33538851 + + + + Hranjec T, Sawyer RG, Young JS et al (2012) Mortality factors in geriatric blunt trauma patients: creation of a highly predictive statistical model for mortality using 50,765 consecutive elderly trauma admissions from the National Sample Project. Am Surg 78:1369–1375 + + 10.1177/000313481207801229 + 23265126 + 3816145 + + + + Ichwan B, Darbha S, Shah MN et al (2015) Geriatric-specific triage criteria are more sensitive than standard adult criteria in identifying need for trauma center care in injured older adults. Ann Emerg Med 65:92–100.e103 + + 10.1016/j.annemergmed.2014.04.019 + 24908590 + + + + Jensen KO, Heyard R, Schmitt D et al (2019) Which pre-hospital triage parameters indicate a need for immediate evaluation and treatment of severely injured patients in the resuscitation area? Eur J Trauma Emerg Surg 45:91–98 + + 10.1007/s00068-017-0889-0 + 29238847 + + + + Kalkwarf KJ, Goodman MD, Press GM et al (2021) Prehospital ABC score accurately forecasts patients who Will require immediate resource utilization. South Med J 114:193–198 + + 10.14423/SMJ.0000000000001236 + 33787930 + + + + Mohan D, Rosengart MR, Farris C et al (2011) Assessing the feasibility of the American College of Surgeons’ benchmarks for the triage of trauma patients. Arch Surg 146:786–792 + + 10.1001/archsurg.2011.43 + 21422329 + 4090942 + + + + Norcross ED, Ford DW, Cooper ME et al (1995) Application of American College of Surgeons’ field triage guidelines by pre-hospital personnel. J Am Coll Surg 181:539–544 + + 7582229 + + + + Paffrath T, Lefering R, Flohe S (2014) How to define severely injured patients?—an Injury Severity Score (ISS) based approach alone is not sufficient. Injury 45(Suppl 3):S64–S69 + + 10.1016/j.injury.2014.08.020 + 25284238 + + + + Passauer-Baierl S, Hofinger G (2011) Teamwork and leadership in the trauma room. Trauma room management from a psychological perspective. Unfallchirurg 114:752–757 + + 10.1007/s00113-011-2026-6 + 21870134 + + + + Santaniello JM, Esposito TJ, Luchette FA et al (2003) Mechanism of injury does not predict acuity or level of service need: field triage criteria revisited. Surgery 134:698–703 (discussion 703–694) + + 10.1016/S0039-6060(03)00331-3 + 14605632 + + + + Sasser SM, Hunt RC, Faul M et al (2012) Guidelines for field triage of injured patients: recommendations of the National Expert Panel on Field Triage, 2011. MMWR Recomm Rep 61:1–20 + + 22237112 + + + + Schweigkofler U, Sauter M, Wincheringer D et al (2020) Emergency room activation due to trauma mechanism. Unfallchirurg 123:386–394 + + 10.1007/s00113-019-00733-1 + 31667554 + + + + Shawhan RR, Mcvay DP, Casey L et al (2015) A simplified trauma triage system safely reduces overtriage and improves provider satisfaction: a prospective study. Am J Surg 209:856–862 (discussion 862–853) + + 10.1016/j.amjsurg.2015.01.008 + 25784644 + + + + Spering C, Roessler M, Kurlemann T et al (2017) Optimized resource mobilization and quality of treatment of severely injured patients through a structured trauma room alarm system. Unfallchirurg. https://doi.org/10.1007/s00113-017-0447-6 + + 10.1007/s00113-017-0447-6 + + + + Statistisches_Bundesamt (2022) https://www.destatis.de/DE/Themen/Querschnitt/Demografischer-Wandel/_inhalt.html;jsessionid=45700D045F2C8FEA849F07BDD82364A6.live732#sprg371138 . Zugegriffen: 25.02.2023 + + + Stephan JC, Grossner T, Stephan-Paulsen LM et al (2021) Evaluation der Aufnahmekriterien von Patienten nach Verkehrsunfall in den Schockraum. Notfall Rettungsmed 24:134–142 + + 10.1007/s10049-020-00695-7 + + + + Stojek L, Bieler D, Neubert A et al (2023) The potential of point-of-care diagnostics to optimise prehospital trauma triage: a systematic review of literature. Eur J Trauma Emerg Surg. https://doi.org/10.1007/s00068-023-02226-8 + + 10.1007/s00068-023-02226-8 + 36703080 + + + + Tignanelli CJ, Kolk EWE, Mikhail JN et al (2018) Noncompliance with American College of Surgeons Committee on Trauma recommended criteria for full trauma team activation is associated with undertriage deaths. J Trauma Acute Care Surg 84:287–294 + + 10.1097/TA.0000000000001745 + 29360717 + + + + Unfallchirurgie DGF (2016) S 3 – Leitlinie Polytrauma/Schwerverletzten-Behandlung. AWMF online:446 + + + Waydhas C, Baacke M, Becker L et al (2018) A consensus-based criterion standard for the requirement of a trauma team. World J Surg. https://doi.org/10.1007/s00268-018-4553-6 + + 10.1007/s00268-018-4553-6 + 29468262 + + + + Werman HA, Erskine T, Caterino J et al (2011) Development of statewide geriatric patients trauma triage criteria. Prehosp Disaster med 26:170–179 + + 10.1017/S1049023X11006315 + 22107767 + + + + +
+ + + 36917226 + + 2023 + 03 + 14 + +
+ + 1708-539X + + + 2023 + Mar + 14 + + + Vascular + Vascular + + Subclavian to carotid artery bypass for a case of ocular ischemic syndrome. + + 17085381231164015 + + 10.1177/17085381231164015 + + Ocular Ischemic Syndrome (OIS) is a rare, vision threatening condition associated with severe carotid artery disease. There are few cases of OIS reported in the literature. + We present the case of a 54-year-old male with history of multiple previous carotid interventions including a right carotid stent, who presented with right-sided OIS. + CTA and angiogram showed a severe calcific plaque causing restenosis of the right carotid stent, with a patent right internal carotid artery (ICA) in the very distal neck. The right common carotid artery (CCA) was patent but diseased with ulcerated plaque extending proximally to below the level of the clavicle. The left CCA was chronically occluded from its origin all the way to the bifurcation. Given our patient's surgical history, the imperative to revascularize the ipsilateral carotid, and a diffusely diseased ipsilateral CCA, he was successfully treated with an ipsilateral subclavian to internal carotid bypass. + There is paucity of data regarding the best approach for carotid revascularization in OIS. This case report discusses our unique perioperative decision making as well as relevant literature. + + + + Sadri + Babak S + BS + 0000-0002-8821-266X + + Department of Surgery, 1147Lehigh Valley Hospital, Allentown, PA, USA. + + + + Low + David W + DW + + Division of Plastic Surgery, 21798Hospital of the University of Pennsylvania, Philadelphia, PA, USA. + + + + Jackson + Oksana A + OA + + Department of Surgery, Division of Plastic, Reconstructive and Oral Surgery, 6567The Children's Hospital of Philadelphia, Philadelphia, PA, USA. + + + + Jackson + Benjamin M + BM + + Department of Surgery, 1147Lehigh Valley Hospital, Allentown, PA, USA. + + + + Belkin + Nathan + N + + Division of Plastic Surgery, 21798Hospital of the University of Pennsylvania, Philadelphia, PA, USA. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + England + Vascular + 101196722 + 1708-5381 + + IM + + Carotid revascularization + carotid artery + hostile neck + ocular ischemic syndrome + subclavian artery + +
+ + + + 2023 + 3 + 14 + 12 + 13 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917226 + 10.1177/17085381231164015 + + +
+ + + 36917225 + + 2023 + 03 + 14 + +
+ + 1529-7268 + + + 2023 + Mar + 14 + + + Biology of reproduction + Biol Reprod + + Establishment and characterisation of oviductal organoids from farm and companion animals. + ioad030 + 10.1093/biolre/ioad030 + + Organoid technology has provided a unique opportunity to study early human development and decipher various steps involved in the pathogenesis of disease. The technology is already used in clinics to improve human patient outcomes. However, limited knowledge of the methodologies required to establish organoid culture systems in domestic animals has slowed the advancement and application of organoid technology in veterinary medicine. This is particularly true for the field of reproduction and the application of assisted reproductive technologies (ART). Here, we have developed a platform to grow oviductal organoids from five domestic species - bovine, porcine, equine, feline, and canine. The organoids were grown progressively from single cells derived from the enzymatic digestion of freshly collected infundibular/fimbrial samples. The addition of WNT, TGFβ, BMP, ROCK, and Notch signalling pathway activators or inhibitors to the organoid culture medium suggested remarkable conservation of the molecular signals involved in oviductal epithelial development and differentiation across species. The gross morphology of organoids from all the domestic species was initially similar. However, some differences in size, complexity, and growth rate were subsequently observed and described. After 21 days, well-defined and synchronized motile ciliated cells were observed in organoids. Histopathologically, oviductal organoids mimicked their respective native tissue. In summary, we have carried out a detailed cross-species comparison of oviductal organoids, which would be valuable in advancing our knowledge of oviduct physiology and, potentially, help in increasing the success of assisted reproductive technologies. + © The Author(s) 2023. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. + + + + Lawson + Edwina F + EF + + Priority Research Centre for Reproductive Science, University of Newcastle, Callaghan, NSW, Australia. + + + + Ghosh + Arnab + A + + Global Centre for Gynaecological Diseases, University of Newcastle, Callaghan, NSW, Australia. + + + School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia. + + + Hunter Medical Research Institute, New Lambton Heights, NSW, Australia. + + + + Blanch + Victoria + V + + Global Centre for Gynaecological Diseases, University of Newcastle, Callaghan, NSW, Australia. + + + School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia. + + + Hunter Medical Research Institute, New Lambton Heights, NSW, Australia. + + + + Grupen + Christopher G + CG + + Sydney School of Veterinary Science, Faculty of Science, University of Sydney, Camden, NSW, Australia. + + + + Aitken + R John + RJ + + Priority Research Centre for Reproductive Science, University of Newcastle, Callaghan, NSW, Australia. + + + + Lim + Rebecca + R + + School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia. + + + Hunter Medical Research Institute, New Lambton Heights, NSW, Australia. + + + + Drury + Hannah R + HR + + School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia. + + + Hunter Medical Research Institute, New Lambton Heights, NSW, Australia. + + + + Baker + Mark A + MA + + Priority Research Centre for Reproductive Science, University of Newcastle, Callaghan, NSW, Australia. + + + Hunter Medical Research Institute, New Lambton Heights, NSW, Australia. + + + + Gibb + Zamira + Z + + Priority Research Centre for Reproductive Science, University of Newcastle, Callaghan, NSW, Australia. + + + + Tanwar + Pradeep S + PS + + Global Centre for Gynaecological Diseases, University of Newcastle, Callaghan, NSW, Australia. + + + School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia. + + + Hunter Medical Research Institute, New Lambton Heights, NSW, Australia. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Biol Reprod + 0207224 + 0006-3363 + + IM + + Disease modelling + Equine + Fertility + Organoids + Oviduct + +
+ + + + 2023 + 3 + 14 + 12 + 13 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917225 + 7077433 + 10.1093/biolre/ioad030 + + +
+ + + 36917228 + + 2023 + 03 + 14 + +
+ + 1531-6971 + + + 2023 + Mar + 15 + + + Current opinion in pulmonary medicine + Curr Opin Pulm Med + + Drug treatment of COVID-19 infection. + 10.1097/MCP.0000000000000953 + + COVID-19 pandemic has caused more than 6.6 million deaths globally. Tremendous efforts have been committed for the development of new and repurposed drugs for the treatment of COVID-19. Although different international and national guidelines share consensus in the management of COVID-19 disease with different levels of severity, new challenges have emerged, steering the need for ongoing research in advancing the clinical management of COVID-19. + This review focuses on recent data from randomized trials and postmarketing real-world evidence for the treatment of mild to moderate disease in the outpatient setting and patients hospitalized for COVID-19 with varying level of severity. Relevant data for treatment of the latest omicron sub-variants in people who received vaccination are presented. Challenges in special populations, including immunocompromised hosts, patients with renal failure and pregnant women, are also discussed. + Treatment of COVID-19 should be personalized according to host characteristics, degree of severity and available treatment options. + Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved. + + + + Lui + Grace + G + + Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR. + + + + Guaraldi + Giovanni + G + + Department of Surgical, Medical, Dental and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy. + + + + eng + + Journal Article + + + 2023 + 03 + 15 + +
+ + United States + Curr Opin Pulm Med + 9503765 + 1070-5287 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 13 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917228 + 10.1097/MCP.0000000000000953 + 00063198-990000000-00060 + + + + World Health Organization. WHO Coronavirus (COVID-19) Dashboard. https://covid19.who.int/on. [Accessed 12 December 2022]. + + + Watson OJ, Barnsley G, Toor J, et al. Global impact of the first year of COVID-19 vaccination: a mathematical modelling study. Lancet Infect Dis 2022; 22:1293–1302. + + + Potter GE, Bonnett T, Rubenstein K, et al. Temporal improvements in COVID-19 outcomes for hospitalized adults: a post hoc observational study of remdesivir group participants in the adaptive COVID-19 treatment trial. Ann Intern Med 2022; 175:1716–1727. + + + Gandhi RT, Lynch JB, Del Rio C. Mild or moderate Covid-19. N Engl J Med 2020; 383:1757–1766. + + + Shah MM, Joyce B, Plumb ID, et al. Paxlovid associated with decreased hospitalization rate among adults with COVID-19 - United States, April-September 2022. MMWR Morb Mortal Wkly Rep 2022; 71:1531–1537. + + + Lim S, Tignanelli CJ, Hoertel N, et al. Prevalence of medical contraindications to nirmatrelvir/ritonavir in a cohort of hospitalized and nonhospitalized patients with COVID-19. Open Forum Infect Dis 2022; 9:ofac389. + + + Jayk Bernal A, Gomes da Silva MM, Musungaie DB, et al. Molnupiravir for oral treatment of Covid-19 in nonhospitalized patients. N Engl J Med 2022; 386:509–520. + + + Hammond J, Leister-Tebbe H, Gardner A, et al. Oral nirmatrelvir for high-risk, nonhospitalized adults with Covid-19. N Engl J Med 2022; 386:1397–1408. + + + Rahmah L, Abarikwu SO, Arero AG, et al. Oral antiviral treatments for COVID-19: opportunities and challenges. Pharmacol Rep 2022; 74:1255–1278. + + + Zarębska-Michaluk D, Flisiak R. Early oral antiviral use in patients hospitalised with COVID-19. Lancet Infect Dis 2022; 22:1650–1651. + + + Nyberg T, Ferguson NM, Nash SG, et al. Comparative analysis of the risks of hospitalisation and death associated with SARS-CoV-2 omicron (B.1.1.529) and delta (B.1.617.2) variants in England: a cohort study. Lancet (London, England) 2022; 399:1303–1312. + + + Wai AK, Chan CY, Cheung AW, et al. Association of Molnupiravir and Nirmatrelvir-Ritonavir with preventable mortality, hospital admissions and related avoidable healthcare system cost among high-risk patients with mild to moderate COVID-19. Lancet Reg Health West Pac 2023; 30:100602. + + + Wong CKH, Au ICH, Lau KTK, et al. Real-world effectiveness of molnupiravir and nirmatrelvir plus ritonavir against mortality, hospitalisation, and in-hospital outcomes among community-dwelling, ambulatory patients with confirmed SARS-CoV-2 infection during the omicron wave in Hong Kong: an observational study. Lancet (London, England) 2022; 400:1213–1222. + + + Najjar-Debbiny R, Gronich N, Weber G, et al. Effectiveness of molnupiravir in high risk patients: a propensity score matched analysis. Clin Infect Dis 2023; 76:453–460. + + + Butler C, Hobbs FDR, Gbinigie O, et al. Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): preliminary analysis from the United Kingdom randomised, controlled open-label, platform adaptive trial (4 October 2022). https://ssrn.com/abstract=4237902. [Accessed 15 December 2022] + + + Johnson MG, Puenpatom A, Moncada PA, et al. Effect of molnupiravir on biomarkers, respiratory interventions, and medical services in COVID-19: a randomized, placebo-controlled trial. Ann Intern Med 2022; 175:1126–1134. + + + Arbel R, Wolff Sagy Y, Hoshen M, et al. Nirmatrelvir use and severe Covid-19 outcomes during the Omicron surge. N Engl J Med 2022; 387:790–798. + + + Dryden-Peterson S, Kim A, Kim AY, et al. Nirmatrelvir plus ritonavir for early COVID-19 in a large U.S. health system: a population-based cohort study. Ann Intern Med 2023; 176:77–84. + + + Najjar-Debbiny R, Gronich N, Weber G, et al. Effectiveness of Paxlovid in reducing severe COVID-19 and mortality in high risk patients. Clin Infect Dis 2023; 76:e342–e349. + + + Goswami H, Alsumali A, Jiang Y, et al. Cost-effectiveness analysis of molnupiravir versus best supportive care for the treatment of outpatient COVID-19 in adults in the US. PharmacoEconomics 2022; 40:699–714. + + + Gottlieb RL, Vaca CE, Paredes R, et al. Early remdesivir to prevent progression to severe Covid-19 in outpatients. N Engl J Med 2022; 386:305–315. + + + Tiseo G, Barbieri C, Galfo V, et al. Efficacy and safety of nirmatrelvir/ritonavir, molnupiravir, and remdesivir in a real-world cohort of outpatients with COVID-19 at high risk of progression: the PISA Outpatient Clinic Experience. Infect Dis Ther 2022; 1–15. + + + Larsen CS. Assessing the proportion of the Danish population at risk of clinically significant drug-drug interactions with new oral antivirals for early treatment of COVID-19. Int J Infect Dis 2022; 122:599–601. + + + Charness ME, Gupta K, Stack G, et al. Rebound of SARS-CoV-2 infection after nirmatrelvir-ritonavir treatment. N Engl J Med 2022; 387:1045–1047. + + + Wang L, Berger NA, Davis PB, et al. COVID-19 rebound after paxlovid and molnupiravir during January-June 2022. medRxiv 2022; 2022.06.21.22276724. + + + Wong GL, Yip TC, Lai MS, et al. Incidence of viral rebound after treatment with nirmatrelvir-ritonavir and molnupiravir. JAMA Netw Open 2022; 5:e2245086. + + + Anderson AS, Caubel P, Rusnak JM. Nirmatrelvir-ritonavir and viral load rebound in Covid-19. N Engl J Med 2022; 387:1047–1049. + + + Epling BP, Rocco JM, Boswell KL, et al. Clinical, virologic, and immunologic evaluation of symptomatic Coronavirus disease 2019 rebound following nirmatrelvir/ritonavir treatment. Clin Infect Dis 2023; 76:573–581. + + + Imai M, Ito M, Kiso M, et al. Efficacy of antiviral agents against Omicron subvariants BQ.1.1 and XBB. N Engl J Med 2023; 388:89–91. + + + Gupta A, Gonzalez-Rojas Y, Juarez E, et al. Effect of sotrovimab on hospitalization or death among high-risk patients with mild to moderate COVID-19: a randomized clinical trial. JAMA 2022; 327:1236–1246. + + + Montgomery H, Hobbs FDR, Padilla F, et al. Efficacy and safety of intramuscular administration of tixagevimab-cilgavimab for early outpatient treatment of COVID-19 (TACKLE): a phase 3, randomised, double-blind, placebo-controlled trial. Lancet Respir Med 2022; 10:985–996. + + + Wynia MK, Beaty LE, Bennett TD, et al. Real-world evidence of neutralizing monoclonal antibodies for preventing hospitalization and mortality in COVID-19 outpatients. Chest 2022; S0012-3692(22)04033-8. + + + Dryden-Peterson S, Kim A, Joyce MR, et al. Bebtelovimab for high-risk outpatients with early COVID-19 in a large US Health System. Open Forum Infect Dis 2022; 9:ofac565. + + + Razonable RR, O’Horo JC, Hanson SN, et al. Outcomes of bebtelovimab treatment is comparable to ritonavir-boosted nirmatrelvir among high-risk patients with Coronavirus disease-2019 during SARS-CoV-2 BA.2 Omicron Epoch. J Infect Dis 2022; 226:1683–1687. + + + Zheng B, Green ACA, Tazare J, et al. Comparative effectiveness of sotrovimab and molnupiravir for prevention of severe covid-19 outcomes in patients in the community: observational cohort study with the OpenSAFELY platform. BMJ (Clinical research ed) 2022; 379:e071932. + + + Arribas JR, Bhagani S, Lobo SM, et al. Randomized trial of molnupiravir or placebo in patients hospitalized with Covid-19. NEJM Evid 2022; 1:EVIDoa2100044. + + + Suzuki Y, Shibata Y, Minemura H, et al. Real-world clinical outcomes of treatment with molnupiravir for patients with mild-to-moderate coronavirus disease 2019 during the Omicron variant pandemic. Clin Exp Med 2022; 1–9. + + + Wong CKH, Au ICH, Lau KTK, et al. Real-world effectiveness of early molnupiravir or nirmatrelvir-ritonavir in hospitalised patients with COVID-19 without supplemental oxygen requirement on admission during Hong Kong's omicron BA.2 wave: a retrospective cohort study. Lancet Infect Dis 2022; 22:1681–1693. + + + Beigel JH, Tomashek KM, Dodd LE, et al. Remdesivir for the treatment of Covid-19: final report. N Engl J Med 2020; 383:1813–1826. + + + Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses. Lancet (London, England) 2022; 399:1941–1953. + + + Diaz GA, Christensen AB, Pusch T, et al. Remdesivir and mortality in patients with Coronavirus disease 2019. Clin Infect Dis 2022; 74:1812–1820. + + + Olender SA, Walunas TL, Martinez E, et al. Remdesivir versus standard-of-care for severe Coronavirus Disease 2019 infection: an analysis of 28-day mortality. Open Forum Infect Dis 2021; 8:ofab27. + + + Chokkalingam AP, Hayden J, Goldman JD, et al. Association of remdesivir treatment with mortality among hospitalized adults with COVID-19 in the United States. JAMA Netw Open 2022; 5:e2244505. + + + Mozaffari E, Chandak A, Zhang Z, et al. Remdesivir treatment in hospitalized patients with Coronavirus Disease 2019 (COVID-19): a comparative analysis of in-hospital all-cause mortality in a large multicenter observational cohort. Clin Infect Dis 2022; 75:e450–e458. + + + Flisiak R, Zarębska-Michaluk D, Rogalska M, et al. Real-world experience with molnupiravir during the period of SARS-CoV-2 Omicron variant dominance. Pharmacol Rep 2022; 74:1279–1285. + + + van de Veerdonk FL, Giamarellos-Bourboulis E, Pickkers P, et al. A guide to immunotherapy for COVID-19. Nat Med 2022; 28:39–50. + + + Bartoletti M, Azap O, Barac A, et al. ESCMID COVID-19 living guidelines: drug treatment and clinical management. Clin Microbiol Infect 2022; 28:222–238. + + + Bhimraj A, Morgan RL, Shumaker AH, et al. Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19. Infectious Diseases Society of America 2022; Version 10.1.1. https://www.idsociety.org/practice-guideline/covid-19-guideline-treatment-and-management/. [Accessed 12 December 2022]. + + + Horby P, Lim WS, Emberson JR, et al. Dexamethasone in hospitalized patients with Covid-19. N Engl J Med 2021; 384:693–704. + + + Bouadma L, Mekontso-Dessap A, Burdet C, et al. High-dose dexamethasone and oxygen support strategies in intensive care unit patients with severe COVID-19 acute hypoxemic respiratory failure: the COVIDICUS Randomized Clinical Trial. 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Safety evaluation of remdesivir for COVID-19 patients with eGFR &lt; 30 mL/min without renal replacement therapy in a Japanese single-center study. Healthcare (Basel, Switzerland) 2022; 10: + + + Ackley TW, McManus D, Topal JE, et al. A valid warning or clinical lore: an evaluation of safety outcomes of remdesivir in patients with impaired renal function from a multicenter matched cohort. Antimicrob Agents Chemother 2021; 65: + + + Seethapathy R, Zhao S, Long JD, et al. A propensity score-matched observational study of remdesivir in patients with COVID-19 and severe kidney disease. Kidney360 2022; 3:269–278. + + + Lim JH, Park SD, Jeon Y, et al. Clinical effectiveness and safety of remdesivir in hemodialysis patients with COVID-19. Kidney Int Rep 2022; 7:2522–2525. + + + Gutierrez R, Mendez-Figueroa H, Biebighauser JG, et al. Remdesivir use in pregnancy during the SARS-CoV-2 pandemic. J Matern Fetal Neonatal Med 2022; 35:9445–9451. + + + Eid J, Abdelwahab M, Colburn N, et al. 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+ + + 36917227 + + 2023 + 03 + 14 + +
+ + 2731-7099 + + + 2023 + Mar + 14 + + + Innere Medizin (Heidelberg, Germany) + Inn Med (Heidelb) + + [Antibiotic allergies: targeted approach in suspected β‑lactam allergy]. + 10.1007/s00108-023-01490-5 + + Allergic reactions to antibiotics belong to hypersensitivity drug reactions and can trigger both immunoglobulin E-mediated symptoms and T cell-mediated symptoms. Skin manifestations are the most common symptoms. Although reporting a penicillin allergy results in considerable restrictions in the treatment of acute infections, which may be associated with poor treatment outcomes, in most cases the label 'penicillin allergy' is not called into question or critically reviewed. However, in 85-90% of patients, 'penicillin allergy' constitutes a mislabeling of a non-specific intolerance reaction that does not pose a risk to the patient when re-exposed to penicillins. Careful history taking, an evaluation of manifestations in the past, and easy-to-perform initial diagnostic steps are crucial in differentiating non-specific intolerance reactions from penicillin allergy sensu stricto. Thus, a penicillin de-labeling strategy allows for optimized antibiotic therapy in the event of a future infection. Although allergic cross-reactivity between different β‑lactam antibiotics can occur, the risk for a severe cross-reactivity is dependent on chemical properties of the specific β‑lactam. Published cross-reactivity tables can help in risk stratification and choice of alternative β‑lactam agents. + © 2023. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature. + + + + Hornuß + Daniel + D + + Klinik für Innere Medizin II, Abteilung Infektiologie, Universitätsklinikum Freiburg, Hugstetter Str. 55, 79106, Freiburg, Deutschland. daniel.hornuss@uniklinik-freiburg.de. + + + + Rieg + Siegbert + S + + Klinik für Innere Medizin II, Abteilung Infektiologie, Universitätsklinikum Freiburg, Hugstetter Str. 55, 79106, Freiburg, Deutschland. + + + + ger + + English Abstract + Journal Article + + Antibiotikaallergien – gezieltes Vorgehen bei vermeintlicher β‑Laktam-Allergie. + + 2023 + 03 + 14 + +
+ + Germany + Inn Med (Heidelb) + 9918384885306676 + 2731-7080 + + IM + + Allergien gegen Antibiotika zählen zu den Arzneimittelüberempfindlichkeitsreaktionen und können sowohl Immunglobulin-E- als auch T‑Zell-vermittelt sein. Hautmanifestationen sind die häufigsten Symptome. Obwohl durch die anamnestische Angabe einer Penicillinallergie erhebliche Einschränkungen in der Therapie akuter Infektionen entstehen, die mit Nebenwirkungen und teilweise schlechteren Therapieergebnissen assoziiert sind, wird die Allergie zumeist nicht kritisch hinterfragt. Bei 85–90 % der Patient*innen mit dem Label „Penicillinallergie“ handelt es sich jedoch um unspezifische Unverträglichkeitsreaktionen ohne Gefährdung bei Reexposition. Eine sogfältige Anamnese der Beschwerden sowie erste einfache diagnostische Schritte können bereits wesentlich zur Klärung einer relevanten Allergie beitragen, um so den Patienten bei antibiotikapflichtiger Infektion die optimale Therapie bieten zu können. Kreuzallergien zwischen verschiedenen β‑Laktam-Antibiotika können auftreten, das Risiko ist jedoch substanzabhängig und kann anhand entsprechender Tabellen eingeschätzt werden. + + + Allergic cross reactivity + Allergy testing + Hypersensitivity/penicillin + Non-specific intolerance reactions + Risk groups/allergy + +
+ + + + 2023 + 01 + 31 + + + 2023 + 3 + 14 + 12 + 13 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917227 + 10.1007/s00108-023-01490-5 + 10.1007/s00108-023-01490-5 + + + Literatur + + Brockow K, Ott H, Przybilla B (2020) Rund um Arzneimittelüberempfindlichkeiten. Allergo J 29:68–77. https://doi.org/10.1007/s15007-020-2589-z + + 10.1007/s15007-020-2589-z + 7483491 + + + + Gomes ER, Demoly P (2005) Epidemiology of hypersensitivity drug reactions. Curr Opin Allergy Clin Immunol 5:309–316. https://doi.org/10.1097/01.all.0000173785.81024.33 + + 10.1097/01.all.0000173785.81024.33 + 15985812 + + + + Miguel A, Azevedo LF, Araújo M et al (2012) Frequency of adverse drug reactions in hospitalized patients: a systematic review and meta-analysis. Pharmacoepidemiol Drug Saf 21:1139–1154. https://doi.org/10.1002/pds.3309 + + 10.1002/pds.3309 + 22761169 + + + + Blumenthal KG, Peter JG, Trubiano JA et al (2019) Antibiotic allergy. 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Allergo J Int 23:96–112. https://doi.org/10.1007/s40629-014-0009-1 + + + Saff RR (2022) Skin testing as a biomarker in drug allergy. Ann Allergy Asthma Immunol. https://doi.org/10.1016/j.anai.2022.10.006 + + 10.1016/j.anai.2022.10.006 + 36243283 + + + + Joint Task Force on Practice Parameters, American Academy of Allergy, Asthma and Immunology, American College of Allergy, Asthma and Immunology et al (2010) Drug allergy: an updated practice parameter. Ann Allergy Asthma Immunol 105:259–273. https://doi.org/10.1016/j.anai.2010.08.002 + + 10.1016/j.anai.2010.08.002 + + + + Shenoy ES, Macy E, Rowe T et al (2019) Evaluation and management of Penicillin allergy: a review. JAMA 321:188–199. https://doi.org/10.1001/jama.2018.19283 + + 10.1001/jama.2018.19283 + 30644987 + + + + Paulmann M, Mockenhaupt M (2019) Severe skin reactions: clinical picture, epidemiology, etiology, pathogenesis, and treatment. Allergo J Int 28:311–326. https://doi.org/10.1007/s40629-019-00111-8 + + 10.1007/s40629-019-00111-8 + + + + Thwaites GE, Edgeworth JD, Gkrania-Klotsas E et al (2011) Clinical management of Staphylococcus aureus bacteraemia. Lancet Infect Dis 11:208–222. https://doi.org/10.1016/S1473-3099(10)70285-1 + + 10.1016/S1473-3099(10)70285-1 + 21371655 + + + + Blumenthal KG, Ryan EE, Li Y et al (2018) The impact of a reported Penicillin allergy on surgical site infection risk. Clin Infect Dis 66:329–336. https://doi.org/10.1093/cid/cix794 + + 10.1093/cid/cix794 + 29361015 + + + + Kawakita T, Huang C‑C, Landy HJ (2018) Choice of prophylactic antibiotics and surgical site infections after cesarean delivery. Obstet Gynecol 132:948–955. https://doi.org/10.1097/AOG.0000000000002863 + + 10.1097/AOG.0000000000002863 + 30204697 + 6353631 + + + + Blumenthal KG, Lu N, Zhang Y et al (2018) Risk of meticillin resistant Staphylococcus aureus and Clostridium difficile in patients with a documented penicillin allergy: population based matched cohort study. BMJ 361:k2400. https://doi.org/10.1136/bmj.k2400 + + 10.1136/bmj.k2400 + 29950489 + 6019853 + + + + Blumenthal KG, Shenoy ES, Varughese CA et al (2015) Impact of a clinical guideline for prescribing antibiotics to inpatients reporting penicillin or cephalosporin allergy. Ann Allergy Asthma Immunol 115:294–300.e2. https://doi.org/10.1016/j.anai.2015.05.011 + + 10.1016/j.anai.2015.05.011 + 26070805 + 4593731 + + + + Devchand M, Kirkpatrick CMJ, Stevenson W et al (2019) Evaluation of a pharmacist-led penicillin allergy de-labelling ward round: a novel antimicrobial stewardship intervention. J Antimicrob Chemother 74:1725–1730. https://doi.org/10.1093/jac/dkz082 + + 10.1093/jac/dkz082 + 30869124 + + + + Krishna MT, Misbah SA (2019) Is direct oral amoxicillin challenge a viable approach for „low-risk“ patients labelled with penicillin allergy? J Antimicrob Chemother 74:2475–2479. https://doi.org/10.1093/jac/dkz229 + + 10.1093/jac/dkz229 + 31167024 + + + + Blumenthal KG, Wickner PG, Hurwitz S et al (2017) Tackling inpatient penicillin allergies: assessing tools for antimicrobial stewardship. J Allergy Clin Immunol 140:154–161.e6. https://doi.org/10.1016/j.jaci.2017.02.005 + + 10.1016/j.jaci.2017.02.005 + 28254470 + 5496780 + + + + Sachs B, Grüger T, Pantke E (2018) Penicillinallergie (1): Wenn die Vermutung nicht zutrifft. Dtsch Ärztebl Online. https://doi.org/10.3238/PersPneumo.2018.06.15.005 + + 10.3238/PersPneumo.2018.06.15.005 + + + + Trcka J, Schäd S, Pfeuffer P et al (2004) Penicillintherapie trotz Penicillinallergie? Plädoyer für eine allergologische Diagnostik bei Verdacht auf Penicillinallergie. Dtsch Ärztebl. https://www.aerzteblatt.de/archiv/43978/Penicillintherapie-trotz-Penicillinallergie-Plaedoyer-fuer-eine-allergologische-Diagnostik-bei-Verdacht-auf-Penicillinallergie ;. Zugegriffen: 25. Okt. 2022 + + + Blumenthal KG, Shenoy ES, Wolfson AR et al (2017) Addressing inpatient beta-lactam allergies: a multihospital implementation. J Allergy Clin Immunol Pract 5:616–625.e7. https://doi.org/10.1016/j.jaip.2017.02.019 + + 10.1016/j.jaip.2017.02.019 + 28483315 + 5484001 + + + + Collins CD, Scheidel C, Anam K et al (2021) Impact of an antibiotic side-chain-based cross-reactivity chart combined with enhanced allergy assessment processes for surgical prophylaxis antimicrobials in patients with β‑Lactam allergies. Clin Infect Dis 72:1404–1412. https://doi.org/10.1093/cid/ciaa232 + + 10.1093/cid/ciaa232 + 32155264 + + + + +
+ + + 36917230 + + 2023 + 03 + 14 + +
+ + 1758-4469 + + + 2023 + Mar + 14 + + + Tree physiology + Tree Physiol + + Upside down and the game of C allocation. + tpad034 + 10.1093/treephys/tpad034 + + Non-structural carbohydrates (NSCs) represent the primary carbon (C) reserves and play a crucial role for plant functioning and resilience. Indeed, these compounds are involved in the regulation between C supply and demand, and in the maintenance of hydraulic efficiency. NSCs are stored in parenchyma of woody organs, which is recognized as a proxy for reserve storage capacity of tree. Notwithstanding the importance of NSCs for tree physiology, their long-term regulation and trade-offs against growth were not deeply investigated. This work evaluated the long-term dynamics of mature tree reserves in stem and root, proxied by parenchyma features, and focusing on the trade off and interplay between the resources allocation in radial growth and reserves in stem and coarse root. In a Mediterranean beech forest, NSCs content, stem and root wood anatomy analysis, and eddy covariance data, were combined. The parenchyma fraction (RAP) of beech root and stem was different, due to differences in axial parenchyma (AP) and narrow ray parenchyma (nRP) fractions. However, these parenchyma components and radial growth showed synchronous inter-annual dynamics between the two organs. In beech stem, positive correlations were found among soluble sugars content and nRP, and among starch content and the AP. Positive correlations were found among Net Ecosystem Exchange (NEE) and AP of both organs. In contrast, NEE was negatively correlated to radial growth of root and stem. Our results suggest a different contribution of stem and roots to reserves storage, and a putative partitioning in the functional roles of parenchyma components. Moreover, a long-term trade-off of C allocation between growth and reserve pool was evidenced. Indeed, in case of C source reduction, trees preferentially allocate C towards reserves pool. Conversely, in high productive years, growth represents the major C sink. + © The Author(s) 2023. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. + + + + Rezaie + Negar + N + + Research Institute on Terrestrial Ecosystems, National Research Council of Italy (CNR-IRET), Via P. Castellino n. 111, 80131 Napoli, Italy. + + + + D'Andrea + Ettore + E + + Research Institute on Terrestrial Ecosystems, National Research Council of Italy (CNR-IRET), via Marconi 2, 05010 Porano (TR), Italy. + + + National Biodiversity Future Center (NBFC), Palermo, Italy. + + + + Scartazza + Andrea + A + + Research Institute on Terrestrial Ecosystems, National Research Council of Italy (CNR-IRET), Via Moruzzi 1, 56124 Pisa, Italy. + + + National Biodiversity Future Center (NBFC), Palermo, Italy. + + + + Gričar + Jožica + J + + Slovenian Forestry Institute, Večna pot 2, 1000 Ljubljana, Slovenia. + + + + Prislan + Peter + P + + Slovenian Forestry Institute, Večna pot 2, 1000 Ljubljana, Slovenia. + + + + Calfapietra + Carlo + C + + Research Institute on Terrestrial Ecosystems, National Research Council of Italy (CNR-IRET), via Marconi 2, 05010 Porano (TR), Italy. + + + National Biodiversity Future Center (NBFC), Palermo, Italy. + + + + Battistelli + Alberto + A + + Research Institute on Terrestrial Ecosystems, National Research Council of Italy (CNR-IRET), via Marconi 2, 05010 Porano (TR), Italy. + + + + Moscatello + Stefano + S + + Research Institute on Terrestrial Ecosystems, National Research Council of Italy (CNR-IRET), via Marconi 2, 05010 Porano (TR), Italy. + + + + Proietti + Simona + S + + Research Institute on Terrestrial Ecosystems, National Research Council of Italy (CNR-IRET), via Marconi 2, 05010 Porano (TR), Italy. + + + + Matteucci + Giorgio + G + + Institute for BioEconomy, National Research Council of Italy (CNR-IBE), via Madonna del Piano, 10 - 50019 Sesto Fiorentino (FI), Italy. + + + National Biodiversity Future Center (NBFC), Palermo, Italy. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Canada + Tree Physiol + 100955338 + 0829-318X + + IM + + Eddy covariance + Fagus sylvatica (beech) + Mediterranean forest + non-structural carbohydrates (NSCs) + wood anatomy + +
+ + + + 2022 + 11 + 24 + + + 2023 + 03 + 02 + + + 2023 + 03 + 11 + + + 2023 + 3 + 14 + 12 + 13 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917230 + 7077437 + 10.1093/treephys/tpad034 + + +
+ + + 36917229 + + 2023 + 03 + 14 + +
+ + 1520-5118 + + + 2023 + Mar + 14 + + + Journal of agricultural and food chemistry + J Agric Food Chem + + Identification and Characterization of Peptides from Bovine Collagen Hydrolysates that Promote Myogenic Cell Proliferation. + 10.1021/acs.jafc.2c08929 + + In this study, bovine collagen hydrolysate was purified via a series of chromatograms, and the peptides with the highest activity for promoting myoblast proliferation were identified by LC-MS-MS. It was demonstrated that the peptide GDAGPPGPAGPAGPPGPIG (hydroxylation) could promote C2C12 proliferation (+18.5% ± 0.04, P < 0.05). The certain peptide was capable of regulating the myogenic cell cycle and inhibiting myogenic cell apoptosis. By combining molecular docking, quantitative real-time PCR, and metabonomics, we suggested that the peptide GDAGPPGPAGPAGPPGPIG (hydroxylation) might bind to FGFR1 and affect the expression of genes downstream of FGFR1 and influence protein synthesis to promote myoblast proliferation. The above results showed that the peptides isolated in this study have the potential to alleviate sarcopenia in the elderly. + + + + Li + Hanfeng + H + 0000-0002-3307-0318 + + Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China. + + + School of Chemical Sciences, University of Chinese Academy of Sciences, Yuquan Road 19A, Beijing 100049, China. + + + + Chen + Xin + X + + Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China. + + + School of Chemical Sciences, University of Chinese Academy of Sciences, Yuquan Road 19A, Beijing 100049, China. + + + + Zuo + Zhijie + Z + + Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China. + + + School of Chemical Sciences, University of Chinese Academy of Sciences, Yuquan Road 19A, Beijing 100049, China. + + + + Wang + Jianing + J + 0000-0003-3802-4270 + + Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China. + + + + Guo + Yanchuan + Y + + Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China. + + + School of Chemical Sciences, University of Chinese Academy of Sciences, Yuquan Road 19A, Beijing 100049, China. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + J Agric Food Chem + 0374755 + 0021-8561 + + IM + + C2C12 + FGFR1 + amino acid synthesis + antiapoptosis + cell cycle + collagen peptide + metabonomics + molecular docking + proliferation + +
+ + + + 2023 + 3 + 14 + 12 + 13 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917229 + 10.1021/acs.jafc.2c08929 + + +
+ + + 36917232 + + 2023 + 03 + 14 + +
+ + 1556-3669 + + 29 + 3 + + 2023 + Mar + + + Telemedicine journal and e-health : the official journal of the American Telemedicine Association + Telemed J E Health + + In Memoriam: Anatoly Ivanovich Grigoriev, MD, PhD. + + 313-314 + + 10.1089/tmj.2023.29092.mem + + + Doarn + Charles R + CR + + Department of Environmental and Public Health Sciences, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA. + + + Office of the Chief Health and Medical Officer, NASA Headquarters, Washington DC, USA. + + + + Nicogossian + Arnauld E + AE + + Schar School of Policy and Government, George Mason University, Arlington, Virginia, USA. + + + American Public University, Charlestown, West Virginia. + + + + Williams + Richard S + RS + + Virginia Department of Health, Richmond, Virginia, USA. + + + NASA Aerospace Safety Advisory Panel, NASA Headquarters, Washington DC, USA. + + + + Polk + J D + JD + + Office of the Chief Health and Medical Officer, NASA Headquarters, Washington DC, USA. + + + + eng + + Journal Article + +
+ + United States + Telemed J E Health + 100959949 + 1530-5627 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 13 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + ppublish + + 36917232 + 10.1089/tmj.2023.29092.mem + + +
+ + + 36917233 + + 2023 + 03 + 14 + +
+ + 1432-5241 + + + 2023 + Mar + 14 + + + Aesthetic plastic surgery + Aesthetic Plast Surg + + Response to "Letter-to-the-editor: Brachioplasty with extended incision at the elbow: a comparison with the traditional short technique". + 10.1007/s00266-023-03310-5 + + + Margara + Andrea + A + + Chief of Plastic Surgery Service, Humanitas Gradenigo Hospital, Turin, Italy. + + + + Gustar + Adrian + A + + Department of Medical Sciences and Public, Health University of Cagliari, 09042, Monserrato, Italy. + + + + Boriani + Filippo + F + http://orcid.org/0000-0002-7739-9801 + + Department of Plastic Surgery and Microsurgery, Struttura complessa di Chirurgia Plastica e Microchirurgia, Policlinico Monserrato, Università di Cagliari, S.S. 554 km 4,5, 09042, Monserrato, CA, Italy. filippo.boriani@unica.it. + + + + eng + + Letter + + + 2023 + 03 + 14 + +
+ + United States + Aesthetic Plast Surg + 7701756 + 0364-216X + + IM +
+ + + + 2023 + 02 + 18 + + + 2023 + 02 + 23 + + + 2023 + 3 + 14 + 12 + 13 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917233 + 10.1007/s00266-023-03310-5 + 10.1007/s00266-023-03310-5 + + + + Margara A, Ponti V, Figus A et al (2022) Brachioplasty with extended incision at the elbow: a comparison with the traditional short technique. Aesthetic Plast Surg. https://doi.org/10.1007/s00266-022-03236-4 + + 10.1007/s00266-022-03236-4 + + + + +
+ + + 36917231 + + 2023 + 03 + 14 + +
+ + 1520-5126 + + + 2023 + Mar + 14 + + + Journal of the American Chemical Society + J Am Chem Soc + + Hexagonal Cobalt Nanosheets for High-Performance Electrocatalytic NO Reduction to NH3. + 10.1021/jacs.3c00276 + + Electrocatalytic nitric oxide (NO) reduction not only provides an extremely promising strategy for ambient NH3 generation but also alleviates the artificially disrupted N-cycle balance. However, exploring efficient electrocatalysts to enhance the NO electroreduction performance remains a significant challenge. Herein, a hexagonal-close-packed Co nanosheet (hcp-Co) is prepared and exhibits a high NH3 yield of 439.50 μmol cm-2 h-1 and a Faraday efficiency of 72.58%, outperforming the face-centered cubic phase of the Co nanosheet (fcc-Co) and most reported electrocatalysts. Through the combination of density functional theory calculations and NO temperature-programmed desorption experiments, the superior catalytic NO reduction reaction (NORR) activity on the hcp-Co can be attributed to the unique electron structures and proton shuttle effect. A proof-of-concept device of Zn-NO batteries using the hcp-Co as the cathode is assembled and shows a power density of 4.66 mW cm-2, which is superior to the reported performance in the literature so far. + + + + Wang + Dongdong + D + 0000-0002-5510-2536 + + State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China. + + + + Chen + Zhi-Wen + ZW + 0000-0002-0155-2101 + + Department of Materials Science and Engineering, University of Toronto, Toronto, ON M5S 3E4, Canada. + + + + Gu + Kaizhi + K + + Institute for Advanced Study, Central South University, Changsha 410083, P. R. China. + + + + Chen + Chen + C + + State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China. + + + + Liu + Yingying + Y + + State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China. + + + + Wei + Xiaoxiao + X + + State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China. + + + + Singh + Chandra Veer + CV + 0000-0002-6644-0178 + + Department of Materials Science and Engineering, University of Toronto, Toronto, ON M5S 3E4, Canada. + + + + Wang + Shuangyin + S + 0000-0001-7185-9857 + + State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + J Am Chem Soc + 7503056 + 0002-7863 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 13 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917231 + 10.1021/jacs.3c00276 + + +
+ + + 36917239 + + 2023 + 03 + 14 + +
+ + 2731-7056 + + + 2023 + Mar + 14 + + + Radiologie (Heidelberg, Germany) + Radiologie (Heidelb) + + [Sports-related injuries of the thumb and fingers]. + 10.1007/s00117-023-01127-6 + + Finger and thumb injuries are common in established and trend sports. Imaging plays an important role in acute trauma care, further therapy planning, and ultimately for a rapid return to play. Sound knowledge of the complex anatomy of the fingers and thumb is indispensable for accurate diagnosis. This article presents the ligament anatomy of the metacarpophalangeal and interphalangeal joints of the finger and the thumb, the extensor and flexor tendon apparatus, and the diagnosis of typical sports injuries using x‑rays and magnetic resonance imaging. Furthermore, imaging findings of typical sports-associated injuries are illustrated. + © 2023. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature. + + + + Hesse + N + N + + Klinik und Poliklinik für Radiologie, Ludwig-Maximilians-Universität (LMU) München, Ziemssenstr. 5, 81377, München, Deutschland. nina.hesse@med.uni-muenchen.de. + + + + Reidler + P + P + + Klinik und Poliklinik für Radiologie, Ludwig-Maximilians-Universität (LMU) München, Ziemssenstr. 5, 81377, München, Deutschland. + + + + Schmitt + R + R + + Klinik und Poliklinik für Radiologie, Ludwig-Maximilians-Universität (LMU) München, Ziemssenstr. 5, 81377, München, Deutschland. + + + Institut für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Würzburg, Würzburg, Deutschland. + + + + ger + + English Abstract + Journal Article + Review + + Sportverletzungen des Daumens und der Finger. + + 2023 + 03 + 14 + +
+ + Germany + Radiologie (Heidelb) + 9918384887306676 + 2731-7048 + + IM + + Verletzungen der Finger und der Daumen sind in den etablierten und Trendsportarten häufig. Die Bildgebung nimmt einen wichtigen Platz in der akuten Traumaversorgung, der weiteren Therapieplanung und letztlich für einen raschen „return to play“ ein. Voraussetzung für die Diagnostik ist eine fundierte Kenntnis der komplexen Anatomie der Finger und des Daumens. Dieser Beitrag stellt die Bandanatomie des Daumengrund-, der Metakarpophalangeal- und der Interphalangealgelenke, den Streck- und Beugesehnenapparat sowie die radiologische Diagnostik typischer Sportverletzungen mittels Projektionsradiographie und Magnetresonanztomographie (MRT) dar. + + + Biomechanics + Finger joint + Lesions + Ligaments + Tendons + +
+ + + + 2023 + 02 + 01 + + + 2023 + 3 + 14 + 12 + 14 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917239 + 10.1007/s00117-023-01127-6 + 10.1007/s00117-023-01127-6 + + + Literatur + + Amadio P (1991) Fracture of the hand and wrist. In: Jupiter JB (Hrsg) Flynn’s hand surgery, 4. Aufl. Williams and Wilkins, Baltimore, S 122–185 + + + Bayer T (2021) Finger injuries with a focus on ligamentous structures. Radiologe 61:426–432 + + 10.1007/s00117-021-00839-x + 33852030 + + + + Carlson MG, Warner KK, Meyers KN et al (2012) Anatomy of the thumb metacarpophalangeal ulnar and radial collateral ligaments. J Hand Surg Am 37:2021–2026 + + 10.1016/j.jhsa.2012.06.024 + 22939823 + + + + Clavero JA, Alomar X, Monill JM et al (2002) MR imaging of ligament and tendon injuries of the fingers. Radiographics 22:237–256 + + 10.1148/radiographics.22.2.g02mr11237 + 11896215 + + + + Clavero JA, Golano P, Farinas O et al (2003) Extensor mechanism of the fingers: MR imaging-anatomic correlation. Radiographics 23:593–611 + + 10.1148/rg.233025079 + 12740463 + + + + Cockenpot E, Lefebvre G, Demondion X et al (2016) Imaging of sports-related hand and wrist injuries: sports imaging series. Radiology 279:674–692 + + 10.1148/radiol.2016150995 + 27183404 + + + + Dray GJ, Eaton RG (2011) Dislocations and ligament injuries in the digits. In: Green DP (Hrsg) Operative hand surgery, Bd. 1. Churchill Livingstone, Edinburgh London Melbourne New York, S 767–798 + + + Ebrahim FS, De Maeseneer M, Jager T et al (2006) US diagnosis of UCL tears of the thumb and Stener lesions: technique, pattern-based approach, and differential diagnosis. Radiographics 26:1007–1020 + + 10.1148/rg.264055117 + 16844929 + + + + Gaston RG, Lourie GM (2006) Radial collateral ligament injury of the index metacarpophalangeal joint: an underreported but important injury. J Hand Surg Am 31:1355–1361 + + 10.1016/j.jhsa.2006.05.015 + 17027799 + + + + Hauger O, Chung CB, Lektrakul N et al (2000) Pulley system in the fingers: normal anatomy and simulated lesions in cadavers at MR imaging, CT, and US with and without contrast material distention of the tendon sheath. Radiology 217:201–212 + + 10.1148/radiology.217.1.r00oc40201 + 11012445 + + + + Hergan K, Mittler C, Oser W (1995) Ulnar collateral ligament: differentiation of displaced and nondisplaced tears with US and MR imaging. Radiology 194:65–71 + + 10.1148/radiology.194.1.7997584 + 7997584 + + + + Hirschmann A, Sutter R, Schweizer A et al (2013) The carpometacarpal joint of the thumb: MR appearance in asymptomatic volunteers. Skelet Radiol 42:1105–1112 + + 10.1007/s00256-013-1633-4 + + + + Leddy JP, Packer JW (1977) Avulsion of the profundus tendon insertion in athletes. J Hand Surg Am 2:66–69 + + 10.1016/S0363-5023(77)80012-9 + 839056 + + + + Manneck S, Del Grande F, Hirschmann A (2021) Ulnar collateral ligament injuries of the first metacarpophalangeal joint: prevalence of associated injuries on radiographs and MRI. Skelet Radiol 50:505–513 + + 10.1007/s00256-020-03575-w + + + + Martinoli C, Bianchi S, Nebiolo M et al (2000) Sonographic evaluation of digital annular pulley tears. Skeletal Radiol 29:387–391 + + 10.1007/s002560000226 + 10963423 + + + + Noszian IM, Dinkhauser LM, Orthner E et al (1995) Ulnar collateral ligament: differentiation of displaced and nondisplaced tears with US. Radiology 194:61–63 + + 10.1148/radiology.194.1.7997583 + 7997583 + + + + Rosskopf AB, Taljanovic MS, Sconfienza LM et al (2021) Pulley, flexor, and extensor tendon injuries of the hand. Semin Musculoskelet Radiol 25:203–215 + + 10.1055/s-0041-1727196 + 34082447 + + + + Ruchelsman DE, Christoforou D, Wasserman B et al (2011) Avulsion injuries of the flexor digitorum profundus tendon. J Am Acad Orthop Surg 19:152–162 + + 10.5435/00124635-201103000-00004 + 21368096 + + + + Schmitt R (2017) Ligament injuries of fingers and thumbs. Radiologe 57:43–56 + + 10.1007/s00117-016-0198-3 + 28078364 + + + + Schmitt R (2014) Projektionsradiografie. In: Schmitt R, Lanz U (Hrsg) Bildgebende Diagnostik der Hand, 3. Aufl. Thieme, Stuttgart, S 28–40 + + + Shapiro LM, Kamal RN (2020) Evaluation and treatment of flexor tendon and pulley injuries in athletes. Clin Sports Med 39:279–297 + + 10.1016/j.csm.2019.12.004 + 32115085 + + + + Spaeth HJ, Abrams RA, Bock GW et al (1993) Gamekeeper thumb: differentiation of nondisplaced and displaced tears of the ulnar collateral ligament with MR imaging. Work in progress. 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+ + + 36917238 + + 2023 + 03 + 14 + +
+ + 1869-1447 + + 33 + 1 + + 2023 + Mar + + + Clinical neuroradiology + Clin Neuroradiol + + New Editor-in-Chief for Clinical Neuroradiology. + + 1 + + 10.1007/s00062-023-01278-y + + + Bendszus + Martin + M + + Abteilung für Neuroradiologie, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany. martin.bendszus@med.uni-heidelberg.de. + + + + eng + + Editorial + + + 2023 + 03 + 14 + +
+ + Germany + Clin Neuroradiol + 101526693 + 1869-1439 + + IM +
+ + + + 2023 + 02 + 09 + + + 2023 + 3 + 14 + 12 + 14 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + ppublish + + 36917238 + 10.1007/s00062-023-01278-y + 10.1007/s00062-023-01278-y + + +
+ + + 36917235 + + 2023 + 03 + 14 + +
+ + 2333-0376 + + 37 + 1 + + 2023 Winter + + + Journal of oral & facial pain and headache + J Oral Facial Pain Headache + + Novel Migraine Treatments: A Review. + + 27-34 + + 10.11607/ofph.3163 + + Aims: To present a review of the mechanisms of action, available clinical data, and safety profiles of novel migraine therapeutics to inform practice. Methods: PubMed, Medline, and Google Scholar were searched for randomized controlled trials (24 publications), review articles (15 publications), and other pertinent literature (16 publications) discussing the novel migraine therapeutics available between the years 2010 and 2021. All publications were reviewed to assess the mechanism of action, relevant clinical data, and side effect profile for each novel treatment. Therapeutic gain was also recorded in studies that included a placebo arm. Results: A total of 55 studies were included in the final analysis. In the preventive treatment of migraine, novel medications target calcitonin gene-related peptide (CGRP) and fall into either the monoclonal anti-CGRP or gepant class. For the acute treatment of migraine, novel medications fall into either the ditan or gepant class. Several medical devices have been developed for the acute and preventive treatment of migraine. Conclusion: Novel therapeutics are available for both the prevention and acute treatment of migraine headaches. These new medications and neuromodulatory devices appear overall to be safe and effective in the management of migraine headaches. + + + + George + Naveen + N + + + Tepper + Stewart J + SJ + + + eng + + Journal Article + +
+ + United States + J Oral Facial Pain Headache + 101624698 + +
+ + + + 2023 + 3 + 14 + 12 + 13 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + ppublish + + 36917235 + 10.11607/ofph.3163 + + +
+ + + 36917234 + + 2023 + 03 + 14 + +
+ + 2333-0376 + + 37 + 1 + + 2023 Winter + + + Journal of oral & facial pain and headache + J Oral Facial Pain Headache + + Investigation of Factors Associated with Dizziness, Tinnitus, and Ear Fullness in Patients with Temporomandibular Disorders. + + 19-26 + + 10.11607/ofph.3286 + + Aims: To determine differences between TMD subtypes in terms of clinical characteristics, dizziness, tinnitus, and ear fullness according to the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) and to investigate the clinical conditions associated with dizziness, tinnitus, and ear fullness. Methods: Participants having TMDs aged 18 to 45 years were included in this study. They were classified and divided into three groups according to the DC/TMD Axis I criteria: group 1 = pain-related TMDs and headache; group 2 = intra-articular joint disorders; and group 3 = degenerative joint disease. Demographic data and dizziness, tinnitus, and ear fullness were assessed. Maximum mouth opening, opening/closing click, lateral click, fine/coarse crepitation, bruxism, and presence of pain were evaluated by physical examination. Results: A total of 129 participants were included: 68 (52.7%) in group 1, 40 (31%) in group 2, and 21 (16.3%) in group 3. In the comparison of all three diagnostic groups, there was a significant difference only in educational level (P = .013). The presence of dizziness, tinnitus, or ear fullness was not found to be significantly different among the three groups. When all participants were divided into two groups according to the presence of dizziness, low education levels (P = .007), being married (P = .040), presence of pain (P = .002), tinnitus (P = .008), ear fullness (P = .017), and presence of thin crepitation (P = .015) were related to having dizziness symptoms. In addition, patients with ear fullness (P = .042), dizziness (P = .008), and female sex (P = .008) reported more tinnitus. Conclusion: TMD subtype was not associated with dizziness, tinnitus, or ear fullness. Painful conditions were associated with dizziness in participants with TMDs. + + + + Karacay + Basak Cigdem + BC + + + Korkmaz + Merve Damla + MD + + + eng + + Journal Article + +
+ + United States + J Oral Facial Pain Headache + 101624698 + +
+ + + + 2023 + 3 + 14 + 12 + 13 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + ppublish + + 36917234 + 10.11607/ofph.3286 + + +
+ + + 36917240 + + 2023 + 03 + 14 + +
+ + 1434-3916 + + + 2023 + Mar + 14 + + + Archives of orthopaedic and trauma surgery + Arch Orthop Trauma Surg + + Short- to mid-term results of minimally invasive lateral unicompartmental knee replacement: 133 cases in a non-designer series. + 10.1007/s00402-023-04841-x + + The aim of the current study was to demonstrate short- to mid-term survivorship as well as clinical outcome of lateral unicompartmental knee replacement (UKR) with a fixed-bearing (FB) design from a non-designer center using the Oxford Fixed Lateral prosthesis. + This single-center retrospective cohort study reports the results of 133 consecutive lateral FB-UKR. Survivorship analysis was performed with different endpoints and clinical outcome was measured using the Oxford-Knee-Score (OKS), American-Knee-Society-Score (AKSS-O), range-of-motion (ROM) and visual-analog-scale for pain (VAS). + There were two revision surgeries with conversion to total knee replacements (TKR) due to persistent pain resulting in a survival rate of 98.5% (95% CI 93.5-99.6) with a mean follow-up (FU) of 3.3 ± 1.8 years (range 1-8.5). All outcome scores, VAS and ROM showed a significant improvement at final FU (p < 0.001). The OKS improved from 26 ± 7.8 (range 11-45) preoperatively to 39 ± 8.3 (range 13-48), the AKSS-O from 49.2 ± 14.6 (range 18-90) to 81.8 ± 15.1 (range 40-100), the AKSS-F from 53 ± 23.7 (range 0-100) to 80.4 ± 21.4 (range 5-100) and the ROM from 118 ± 17 (range 90-160) to 134 ± 9.5 (range 100-155). + The short- to mid-term results following lateral FB-UKR demonstrate a high survivorship and good clinical outcome from an independent series. We, therefore, suggest that FB-UKR is a safe treatment option for isolated lateral OA if sufficient surgical experience is provided. + Retrospective cohort study, level IV. + © 2023. The Author(s). + + + + Hariri + Mustafa + M + + Department of Orthopaedics, Heidelberg University Hospital, Schlierbacher Landstrasse 200a, 69118, Heidelberg, Germany. + + + + Hagemann + Merlin + M + + Department of Orthopaedics, Heidelberg University Hospital, Schlierbacher Landstrasse 200a, 69118, Heidelberg, Germany. + + + + Koch + Kevin-Arno + KA + + Department of Orthopaedics, Heidelberg University Hospital, Schlierbacher Landstrasse 200a, 69118, Heidelberg, Germany. + + + + Reiner + Tobias + T + + Department of Orthopaedics, Heidelberg University Hospital, Schlierbacher Landstrasse 200a, 69118, Heidelberg, Germany. + + + + Panzram + Benjamin + B + + Department of Orthopaedics, Heidelberg University Hospital, Schlierbacher Landstrasse 200a, 69118, Heidelberg, Germany. + + + + Merle + Christian + C + + Department of Orthopaedics, Heidelberg University Hospital, Schlierbacher Landstrasse 200a, 69118, Heidelberg, Germany. + + + + Renkawitz + Tobias + T + + Department of Orthopaedics, Heidelberg University Hospital, Schlierbacher Landstrasse 200a, 69118, Heidelberg, Germany. + + + + Walker + Tilman + T + http://orcid.org/0000-0002-9876-2083 + + Department of Orthopaedics, Heidelberg University Hospital, Schlierbacher Landstrasse 200a, 69118, Heidelberg, Germany. tilman.walker@med.uni-heidelberg.de. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Arch Orthop Trauma Surg + 9011043 + 0936-8051 + + IM + + Fixed bearing + Lateral unicompartmental knee replacement + Partial knee arthroplasty + UKA + UKR + +
+ + + + 2022 + 12 + 28 + + + 2023 + 03 + 01 + + + 2023 + 3 + 14 + 12 + 14 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917240 + 10.1007/s00402-023-04841-x + 10.1007/s00402-023-04841-x + + + + Sah AP, Scott RD (2007) Lateral unicompartmental knee arthroplasty through a medial approach. Study with an average five-year follow-up. J Bone Jt Surg Am 89(9):1948–1954. https://doi.org/10.2106/JBJS.F.01457 + + 10.2106/JBJS.F.01457 + + + + Ekeland A, Nerhus TK, Dimmen S, Heir S (2016) Good functional results of distal femoral opening-wedge osteotomy of knees with lateral osteoarthritis. Knee Surg Sports Traumatol Arthrosc 24(5):1702–1709. https://doi.org/10.1007/s00167-016-3988-2 + + 10.1007/s00167-016-3988-2 + 26792566 + + + + de Carvalho Jr. LH, Temponi EF, Soares LF, Goncalves MB, Costa LP (2014) Physical activity after distal femur osteotomy for the treatment of lateral compartment knee osteoarthritis. Knee Surg Sports Traumatol Arthrosc 22(7):1607–1611. https://doi.org/10.1007/s00167-012-2316-8 + + 10.1007/s00167-012-2316-8 + 23232785 + + + + Heyse TJ, Tibesku CO (2010) Lateral unicompartmental knee arthroplasty: a review. Arch Orthop Trauma Surg 130(12):1539–1548. https://doi.org/10.1007/s00402-010-1137-9 + + 10.1007/s00402-010-1137-9 + 20559645 + + + + Liddle AD, Judge A, Pandit H, Murray DW (2014) Adverse outcomes after total and unicompartmental knee replacement in 101,330 matched patients: a study of data from the National Joint Registry for England and Wales. Lancet 384(9952):1437–1445. https://doi.org/10.1016/S0140-6736(14)60419-0 + + 10.1016/S0140-6736(14)60419-0 + 25012116 + + + + Lombardi AV Jr, Berend KR, Walter CA, Aziz-Jacobo J, Cheney NA (2009) Is recovery faster for mobile-bearing unicompartmental than total knee arthroplasty? 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Knee 20(6):466–470. https://doi.org/10.1016/j.knee.2012.11.008 + + 10.1016/j.knee.2012.11.008 + 23274066 + + + + Murray DW, Liddle AD, Dodd CA, Pandit H (2015) Unicompartmental knee arthroplasty: is the glass half full or half empty? Bone Jt J 97B(10 Suppl A):3–8. https://doi.org/10.1302/0301-620X.97B10.36542 + + 10.1302/0301-620X.97B10.36542 + + + + Kerens B, Boonen B, Schotanus MG, Lacroix H, Emans PJ, Kort NP (2013) Revision from unicompartmental to total knee replacement: the clinical outcome depends on reason for revision. Bone Joint J 95B(9):1204–1208. https://doi.org/10.1302/0301-620X.95B9.31085 + + 10.1302/0301-620X.95B9.31085 + + + + +
+ + + 36917248 + + 2023 + 03 + 14 + +
+ + 1433-7347 + + + 2023 + Mar + 14 + + + Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA + Knee Surg Sports Traumatol Arthrosc + + Navigated functional alignment total knee arthroplasty achieves reliable, reproducible and accurate results with high patient satisfaction. + 10.1007/s00167-023-07327-w + + The decision on which technique to perform a total knee arthroplasty (TKA) has become more complicated over the last decade. Perceived limitations of mechanical alignment (MA) and kinematic alignment (KA) have led to the development of the functional alignment (FA) philosophy. This study aims to report the 2-year results of an initial patient cohort in terms of revision rate, PROMs and complications for Computer Aided Surgery (CAS) Navigated FA TKA. + This paper reports a single surgeon's outcomes of 165 consecutive CAS FA TKAs. The final follow-up was 24 months. Pre-operative and post-operative patient-reported outcome measures, WOMAC and KSS, and intra-operative CAS data, including alignment, kinematic curves, and gaps, are reported. Stress kinematic curves were analysed for correlation with CAS final alignment and CAS final alignment with radiographic long-leg alignment. Pre- and post-operative CPAK and knee phenotypes were recorded. Three different types of prostheses from two manufacturers were used, and outcomes were compared. Soft tissue releases, revision and complication data are also reported. + Mean pre-operative WOMAC was 48.8 and 1.2 at the time of the final follow-up. KSS was 48.8 and 93.7, respectively. Pre- and post-operative range of motion was 118.6° and 120.1°, respectively. Pre-operative and final kinematic curve prediction had an accuracy of 91.8%. CAS data pre-operative stress alignment and final alignment strongly correlate in extension and flexion, r = 0.926 and 0.856, p < 0.001. No statistical outcome difference was detected between the types of prostheses. 14.5% of patients required soft tissue release, with the lateral release (50%) and posterior capsule (29%) being the most common. + CAS FA TKA in this cohort proved to be a predictable, reliable, and reproducible technique with acceptable short-term revision rates and high PROMs. FA can account for extremes in individual patient bony morphology and achieve desired gap and kinematic targets with soft tissue releases required in only 14.5% of patients. + IV (retrospective case series review). + © 2023. The Author(s). + + + + Hazratwala + Kaushik + K + http://orcid.org/0000-0002-0649-9231 + + The Orthopaedic Research Institute of Queensland (ORIQL), 7 Turner Street, Pimlico, Townsville, QLD, 4812, Australia. drkosh@qllc.com.au. + + + Mater Health Services North Queensland Ltd, 21-37 Fulham Road, Pimlico, Townsville, QLD, 4812, Australia. drkosh@qllc.com.au. + + + Townsville University Hospital, 100 Angus Smith Drive, Douglas, Townsville, QLD, 4814, Australia. drkosh@qllc.com.au. + + + James Cook University, 1 James Cook Drive, Townsville, QLD, 4811, Australia. drkosh@qllc.com.au. + + + + Gouk + Conor + C + + The Orthopaedic Research Institute of Queensland (ORIQL), 7 Turner Street, Pimlico, Townsville, QLD, 4812, Australia. + + + Townsville University Hospital, 100 Angus Smith Drive, Douglas, Townsville, QLD, 4814, Australia. + + + Cairn Base Hospital, 165 Esplanade, Cairns, QLD, 4870, Australia. + + + James Cook University, 1 James Cook Drive, Townsville, QLD, 4811, Australia. + + + + Wilkinson + Matthew P R + MPR + + The Orthopaedic Research Institute of Queensland (ORIQL), 7 Turner Street, Pimlico, Townsville, QLD, 4812, Australia. + + + University of Tasmania, Churchill Avenue, Hobart, TAS, 7005, Australia. + + + + O'Callaghan + William B + WB + + The Orthopaedic Research Institute of Queensland (ORIQL), 7 Turner Street, Pimlico, Townsville, QLD, 4812, Australia. + + + Mater Health Services North Queensland Ltd, 21-37 Fulham Road, Pimlico, Townsville, QLD, 4812, Australia. + + + Townsville University Hospital, 100 Angus Smith Drive, Douglas, Townsville, QLD, 4814, Australia. + + + Cairn Base Hospital, 165 Esplanade, Cairns, QLD, 4870, Australia. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Knee Surg Sports Traumatol Arthrosc + 9314730 + 0942-2056 + + IM + + Functional alignment + Kinematic alignment + Mechanical alignment + Total knee arthroplasty + Total knee replacement + +
+ + + + 2022 + 08 + 14 + + + 2023 + 01 + 26 + + + 2023 + 3 + 14 + 12 + 14 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917248 + 10.1007/s00167-023-07327-w + 10.1007/s00167-023-07327-w + + + + AOANJRR (2022) Hip Knee and Shoulder Arthroplasty: 2022 Annual Report Adelaide: AOA. https://aoanjrr.sahmri.com/annual-reports-2022 1–487 + + + Chang JS, Kayani B, Wallace C, Haddad FS (2021) Functional alignment achieves soft-tissue balance in total knee arthroplasty as measured with quantitative sensor-guided technology. Bone Joint J 103-b:507–514 + + 10.1302/0301-620X.103B.BJJ-2020-0940.R1 + 33467917 + + + + Chen JY, Chin PL, Li Z, Yew AK, Tay DK, Chia SL et al (2015) Radiological outcomes of pinless navigation in total knee arthroplasty: a randomized controlled trial. Knee Surg Sports Traumatol Arthrosc 23:3556–3562 + + 10.1007/s00167-014-3226-8 + 25119055 + + + + Choi BS, Kim SE, Yang M, Ro DH, Han HS (2022) Functional alignment with robotic-arm assisted total knee arthroplasty demonstrated better patient-reported outcomes than mechanical alignment with manual total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc. https://doi.org/10.1007/s00167-022-07227-5 + + 10.1007/s00167-022-07227-5 + 36378291 + + + + Clark G, Steer R, Wood D (2022) Functional alignment achieves a more balanced total knee arthroplasty than either mechanical alignment or kinematic alignment prior to soft tissue releases. Knee Surg Sports Traumatol Arthrosc. https://doi.org/10.1007/s00167-022-07156-3 + + 10.1007/s00167-022-07156-3 + 36116071 + + + + Drexler M, Dwyer T, Chakravertty R, Farno A, Backstein D (2013) Assuring the happy total knee replacement patient. Bone Joint J 95-b:120–123 + + 10.1302/0301-620X.95B11.32949 + 24187368 + + + + Grant AL, Doma KD, Hazratwala K (2017) Determination of the accuracy of navigated kinematic unicompartmental knee arthroplasty: a 2-year follow-up. J Arthroplasty 32:1443–1452 + + 10.1016/j.arth.2016.11.036 + 28039023 + + + + Gundle KR, White JK, Conrad EU, Ching RP (2017) Accuracy and precision of a surgical navigation system: effect of camera and patient tracker position and number of active markers. Open Orthop J 11:493–501 + + 10.2174/1874325001711010493 + 28694888 + 5481622 + + + + Halawi MJ, Jongbloed W, Baron S, Savoy L, Williams VJ, Cote MP (2019) Patient dissatisfaction after primary total joint arthroplasty: the patient perspective. J Arthroplasty 34:1093–1096 + + 10.1016/j.arth.2019.01.075 + 30799270 + + + + Hazratwala K, Brereton SG, Grant A, Dlaska CE (2020) Computer-assisted technologies in arthroplasty: navigating your way today. JBJS Rev 8:e0157 + + 10.2106/JBJS.RVW.19.00157 + 32224641 + + + + Hazratwala K, O’Callaghan WB, Dhariwal S, Wilkinson MPR (2022) Wide variation in tibial slopes and trochlear angles in the arthritic knee: a CT evaluation of 4116 pre-operative knees. Knee Surg Sports Traumatol Arthrosc 30:3049–3060 + + 10.1007/s00167-021-06725-2 + 34487188 + + + + Hess S, Moser LB, Robertson EL, Behrend H, Amsler F, Iordache E et al (2022) Osteoarthritic and non-osteoarthritic patients show comparable coronal knee joint line orientations in a cross-sectional study based on 3D reconstructed CT images. Knee Surg Sports Traumatol Arthrosc 30:407–418 + + 10.1007/s00167-021-06740-3 + 34564737 + + + + Hirschmann MT, Moser LB, Amsler F, Behrend H, Leclerq V, Hess S (2019) Functional knee phenotypes: a novel classification for phenotyping the coronal lower limb alignment based on the native alignment in young non-osteoarthritic patients. Knee Surg Sports Traumatol Arthrosc 27:1394–1402 + + 10.1007/s00167-019-05509-z + 30976825 + + + + Jones CW, Jerabek SA (2018) Current role of computer navigation in total knee arthroplasty. J Arthroplasty 33:1989–1993 + + 10.1016/j.arth.2018.01.027 + 29506932 + + + + Kayani B, Haddad FS (2019) Robotic total knee arthroplasty: clinical outcomes and directions for future research. Bone Joint Res 8:438–442 + + 10.1302/2046-3758.810.BJR-2019-0175 + 31728181 + 6825042 + + + + Kayani B, Konan S, Tahmassebi J, Oussedik S, Moriarty PD, Haddad FS (2020) A prospective double-blinded randomised control trial comparing robotic arm-assisted functionally aligned total knee arthroplasty versus robotic arm-assisted mechanically aligned total knee arthroplasty. Trials 21:194 + + 10.1186/s13063-020-4123-8 + 32070406 + 7027302 + + + + Kort N, Stirling P, Pilot P, Müller JH (2022) Robot-assisted knee arthroplasty improves component positioning and alignment, but results are inconclusive on whether it improves clinical scores or reduces complications and revisions: a systematic overview of meta-analyses. Knee Surg Sports Traumatol Arthrosc 30:2639–2653 + + 10.1007/s00167-021-06472-4 + 33666686 + + + + MacDessi SJ, Griffiths-Jones W, Harris IA, Bellemans J, Chen DB (2021) Coronal plane alignment of the knee (CPAK) classification. Bone Joint J 103-b:329–337 + + 10.1302/0301-620X.103B2.BJJ-2020-1050.R1 + 33517740 + 7954147 + + + + Nam D, Nunley RM, Barrack RL (2014) Patient dissatisfaction following total knee replacement: a growing concern? Bone Joint J 96-b:96–100 + + 10.1302/0301-620X.96B11.34152 + 25381418 + + + + O’Callaghan WB, Gouk C, Wilkinson MPR, Haztratwala K (2022) Computer-aided surgery-navigated, functional alignment total knee arthroplasty: a surgical technique. Arthroplasty Today 14:121–127 + + 10.1016/j.artd.2022.01.029 + 35295192 + 8919216 + + + + Oussedik S, Abdel MP, Victor J, Pagnano MW, Haddad FS (2020) Alignment in total knee arthroplasty. Bone Joint J 102-b:276–279 + + 10.1302/0301-620X.102B3.BJJ-2019-1729 + 32114811 + + + + Sappey-Marinier E, Pauvert A, Batailler C, Swan J, Cheze L, Servien E et al (2020) Kinematic versus mechanical alignment for primary total knee arthroplasty with minimum 2 years follow-up: a systematic review. SICOT J 6:18 + + 10.1051/sicotj/2020014 + 32553101 + 7301633 + + + + Scott CE, Howie CR, MacDonald D, Biant LC (2010) Predicting dissatisfaction following total knee replacement: a prospective study of 1217 patients. J Bone Joint Surg Br 92:1253–1258 + + 10.1302/0301-620X.92B9.24394 + 20798443 + + + + Steer R, Tippett B, Khan RN, Collopy D, Clark G (2021) A prospective randomised control trial comparing functional with mechanical axis alignment in total knee arthroplasty: study protocol for an investigator initiated trial. Trials 22:523 + + 10.1186/s13063-021-05433-z + 34372888 + 8351154 + + + + Tarassoli P, Wood JA, Chen DB, Griffiths-Jones W, Bellemans J, MacDessi SJ (2022) Arithmetic hip-knee-ankle angle and stressed hip-knee-ankle angle: equivalent methods for estimating constitutional lower limb alignment in kinematically aligned total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc. https://doi.org/10.1007/s00167-022-07038-8 + + 10.1007/s00167-022-07038-8 + 35819463 + 9418303 + + + + Tokuhara Y, Kadoya Y, Kanekasu K, Kondo M, Kobayashi A, Takaoka K (2006) Evaluation of the flexion gap by axial radiography of the distal femur. J Bone Joint Surg Br 88:1327–1330 + + 10.1302/0301-620X.88B10.17793 + 17012422 + + + + Ueyama H, Kanemoto N, Minoda Y, Nakagawa S, Taniguchi Y, Nakamura H (2022) Association of a wider medial gap (medial laxity) in flexion with self-reported knee instability after medial-pivot total knee arthroplasty. J Bone Joint Surg Am 104:910–918 + + 10.2106/JBJS.21.01034 + 35320136 + + + + Zha GC, Sun JY, Dong SJ (2014) Less anterior knee pain with a routine lateral release in total knee arthroplasty without patellar resurfacing: a prospective, randomized study. Knee Surg Sports Traumatol Arthrosc 22:517–525 + + 10.1007/s00167-013-2789-0 + 24288077 + + + + +
+ + + 36917247 + + 2023 + 03 + 14 + +
+ + 1433-7347 + + + 2023 + Mar + 14 + + + Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA + Knee Surg Sports Traumatol Arthrosc + + Comparable accuracy of femoral joint line reconstruction in different kinematic and functional alignment techniques. + 10.1007/s00167-023-07360-9 + + A key part of kinematic alignment (KA) and functional alignment (FA) is to restore the natural femoral joint line, in particular the medial joint line. KA is known to reproduce the femoral joint line accurately; however, direct comparisons with other surgical techniques such as FA are currently lacking. The purpose of this study was to evaluate differences of alignment parameters in KA and FA techniques with a special focus given to the femoral joint line. + We performed a retrospective radiological analysis of pre- and postoperative long leg radiographs of 221 consecutive patients with varus or neutral leg alignment, who underwent primary total knee arthroplasty (TKA) procedures from 2018 to 2020. Patients were assigned to one of four groups: (1) FA: image-based robotic-assisted TKA, (2) FA: imageless robotic-assisted TKA, (3): restricted KA: 3D cutting block-assisted (patient-specific instruments, PSI) TKA, (4): unrestricted KA: calipered technique. Patients' radiographs were (re)-analyzed for overall limb alignment, medial proximal tibial angle (MPTA), lateral distal femoral angle (LDFA), as well as medial and lateral femoral joint line alteration. Statistical significance was determined using unpaired t testing (FA vs. KA group) and one-way ANOVA (subgroup analyses). + Comparisons of KA vs. FA, as well as individual subgroups of KA and FA did not show any differences in the accuracy of medial joint line reconstruction (< 2 mm, p = 0.384, p = 0.744, respectively) and LDFA alteration (< 2°, p = 0.997, 0.921, respectively). Correction of MPTA (3.4° vs. 2.2°) and lateral femoral joint line (2.1 mm vs. 1.5 mm) was higher for FA and FA subgroups compared to KA and KA subgroups (both p < 0.001). + Kinematic and functional alignments showed a comparable accuracy in reconstruction of the medial femoral joint line and femoral joint line orientation. Increased correction of MPTA and lateral femoral joint line was recorded with FA techniques. + III. + © 2023. The Author(s) under exclusive licence to European Society of Sports Traumatology, Knee Surgery, Arthroscopy (ESSKA). + + + + Tuecking + Lars-Rene + LR + http://orcid.org/0000-0003-3370-7064 + + Department of Orthopaedic Surgery, Hannover Medical School, Diakovere Annastift, Anna Von Borries Str. 1-6, 30625, Hannover, Germany. Lars-rene.tuecking@diakovere.de. + + + + Savov + Peter + P + + Department of Orthopaedic Surgery, Hannover Medical School, Diakovere Annastift, Anna Von Borries Str. 1-6, 30625, Hannover, Germany. + + + Department of Orthopaedic and Trauma Surgery, Pius Hospital, Carl von Ossietzky University of Oldenburg, Oldenburg, Germany. + + + + Zander + Mats + M + + Department of Orthopaedic Surgery, Hannover Medical School, Diakovere Annastift, Anna Von Borries Str. 1-6, 30625, Hannover, Germany. + + + + Jeremic + Dragan + D + + Department of Orthopaedic Surgery, St.Vincenz Hospital Brakel, Danziger Str. 17, 33034, Brakel, Germany. + + + + Windhagen + Henning + H + + Department of Orthopaedic Surgery, Hannover Medical School, Diakovere Annastift, Anna Von Borries Str. 1-6, 30625, Hannover, Germany. + + + + Ettinger + Max + M + + Department of Orthopaedic Surgery, Hannover Medical School, Diakovere Annastift, Anna Von Borries Str. 1-6, 30625, Hannover, Germany. + + + Department of Orthopaedic and Trauma Surgery, Pius Hospital, Carl von Ossietzky University of Oldenburg, Oldenburg, Germany. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Knee Surg Sports Traumatol Arthrosc + 9314730 + 0942-2056 + + IM + + Accuracy + Functional alignment + Joint line + Kinematic alignment + PSI + RA-TKA + Robotic TKA + Total knee arthroplasty + Unrestricted KA + +
+ + + + 2022 + 10 + 29 + + + 2023 + 02 + 21 + + + 2023 + 3 + 14 + 12 + 14 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917247 + 10.1007/s00167-023-07360-9 + 10.1007/s00167-023-07360-9 + + + + Agrawal VO, Gadekar AP, Vaidya N (2022) Does robotic technology successfully restore the joint line after total knee arthroplasty? A retrospective analysis. Arthroplasty 4:6 + + 10.1186/s42836-021-00103-6 + 35236508 + 8796510 + + + + Chang JS, Kayani B, Wallace C, Haddad FS (2021) Functional alignment achieves soft-tissue balance in total knee arthroplasty as measured with quantitative sensor-guided technology. Bone Jt J 103-B:507–514 + + 10.1302/0301-620X.103B.BJJ-2020-0940.R1 + + + + D’Amato M, Kosse NM, Wymenga AB (2021) Restoration of pre-operative joint line orientation and alignment does not affect KSS and KOOS 1 year after total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc 29:3170–3177 + + 10.1007/s00167-020-06097-z + 32556430 + + + + Eckhoff D, Hogan C, DiMatteo L, Robinson M, Bach J (2007) An ABJS BEST PAPER: difference between the epicondylar and cylindrical axis of the knee. Clin Orthop 461:238–244 + + 10.1097/BLO.0b013e318112416b + 17549027 + + + + Hollister AM, Jatana S, Singh AK, Sullivan WW, Lupichuk AG (1993) The axes of rotation of the knee. Clin Orthop 290:259–268 + + 10.1097/00003086-199305000-00033 + + + + Howell SM (2019) Calipered kinematically aligned total knee arthroplasty: an accurate technique that improves patient outcomes and implant survival. Orthopedics 42:126–135 + + 10.3928/01477447-20190424-02 + 31099877 + + + + Howell SM, Nedopil AJ, Hull ML (2022) Negligible effect of surgeon experience on the accuracy and time to perform unrestricted caliper verified kinematically aligned TKA with manual instruments. Knee Surg Sports Traumatol Arthrosc 30:2966–2974 + + 10.1007/s00167-022-06939-y + 35366075 + 9418297 + + + + Kayani B, Konan S, Ayuob A, Onochie E, Al-Jabri T, Haddad FS (2019) Robotic technology in total knee arthroplasty: a systematic review. EFORT Open Rev 4:611–617 + + 10.1302/2058-5241.4.190022 + 31754467 + 6836078 + + + + Kim J-T, Han J, Lim S, Shen QH, Won YY (2019) Kinematically aligned TKA aligns the ankle joint line closer to those of the native ankle than mechanically aligned TKA in bipedal stance. J Knee Surg 32:1033–1038 + + 10.1055/s-0039-1694796 + 31434142 + + + + Li G, Park SE, DeFrate LE, Schutzer ME, Ji L, Gill TJ, Rubash HE (2005) The cartilage thickness distribution in the tibiofemoral joint and its correlation with cartilage-to-cartilage contact. Clin Biomech Bristol Avon 20:736–744 + + 10.1016/j.clinbiomech.2005.04.001 + 15963613 + + + + Liow MHL, Xia Z, Wong MK, Tay KJ, Yeo SJ, Chin PL (2014) Robot-assisted total knee arthroplasty accurately restores the joint line and mechanical axis. A prospective randomised study. J Arthroplasty 29:2373–2377 + + 10.1016/j.arth.2013.12.010 + 24439796 + + + + Luyckx T, Vandenneucker H, Ing LS, Vereecke E, Ing AV, Victor J (2018) Raising the joint line in TKA is associated with mid-flexion laxity: a study in cadaver knees. Clin Orthop 476:601–611 + + 10.1007/s11999.0000000000000067 + 29443845 + 6260050 + + + + MacDessi SJ, Griffiths-Jones W, Harris IA, Bellemans J, Chen DB (2021) Coronal plane alignment of the knee (CPAK) classification: a new system for describing knee phenotypes. Bone Jt J 103-B:329–337 + + 10.1302/0301-620X.103B2.BJJ-2020-1050.R1 + + + + Nedopil AJ, Howell SM, Hull ML (2020) Deviations in femoral joint lines using calipered kinematically aligned TKA from virtually planned joint lines are small and do not affect clinical outcomes. Knee Surg Sports Traumatol Arthrosc 28:3118–3127 + + 10.1007/s00167-019-05776-w + 31768572 + + + + Niki Y, Nagura T, Nagai K, Kobayashi S, Harato K (2018) Kinematically aligned total knee arthroplasty reduces knee adduction moment more than mechanically aligned total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc 26:1629–1635 + + 10.1007/s00167-017-4788-z + 29204861 + + + + Oussedik S, Abdel MP, Victor J, Pagnano MW, Haddad FS (2020) Alignment in total knee arthroplasty: what’s in a name? Bone Jt J 102-B:276–279 + + 10.1302/0301-620X.102B3.BJJ-2019-1729 + + + + Rivière C, Harman C, Boughton O, Cobb J (2020) The kinematic alignment technique for total knee arthroplasty. In: Rivière C, Vendittoli P-A (eds) Pers hip knee jt replace. Springer International Publishing, Cham, pp 175–195 + + 10.1007/978-3-030-24243-5_16 + + + + Rivière C, Iranpour F, Harris S, Auvinet E, Aframian A, Chabrand P, Cobb J (2017) The kinematic alignment technique for TKA reliably aligns the femoral component with the cylindrical axis. Orthop Traumatol Surg Res 103:1069–1073 + + 10.1016/j.otsr.2017.06.016 + 28870873 + + + + Sappey-Marinier E, Batailler C, Swan J, Schmidt A, Cheze L, MacDessi SJ, Servien E, Lustig S (2021) Mechanical alignment for primary TKA may change both knee phenotype and joint line obliquity without influencing clinical outcomes: a study comparing restored and unrestored joint line obliquity. Knee Surg Sports Traumatol Arthrosc 30:2806–2814 + + 10.1007/s00167-021-06674-w + 34291311 + + + + Shah RF, Martinez AM, Pedoia V, Majumdar S, Vail TP, Bini SA (2019) Variation in the thickness of knee cartilage. The use of a novel machine learning algorithm for cartilage segmentation of magnetic resonance images. J Arthroplasty 34:2210–2215 + + 10.1016/j.arth.2019.07.022 + 31445869 + 7251923 + + + + Shatrov J, Battelier C, Sappey-Marinier E, Gunst S, Servien E, Lustig S (2022) Functional alignment philosophy in total knee arthroplasty—rationale and technique for the varus morphotype using a CT based robotic platform and individualized planning. SICOT-J 8:11 + + 10.1051/sicotj/2022010 + 35363136 + 8973302 + + + + Shepherd DET, Seedhom BB (1999) Thickness of human articular cartilage in joints of the lower limb. Ann Rheum Dis 58:27–34 + + 10.1136/ard.58.1.27 + 10343537 + 1752762 + + + + Tuecking L-R, Ettinger M, Nebel D, Welke B, Schwarze M, Windhagen H, Savov P (2021) 3D-surface scan based validated new measurement technique of femoral joint line reconstruction in total knee arthroplasty. J Exp Orthop 8:16 + + 10.1186/s40634-021-00330-5 + 33634333 + 7907296 + + + + Vaidya NV, Deshpande AN, Panjwani T, Patil R, Jaysingani T, Patil P (2020) Robotic-assisted TKA leads to a better prosthesis alignment and a better joint line restoration as compared to conventional TKA: a prospective randomized controlled trial. Knee Surg Sports Traumatol Arthrosc 30:621–626 + + 10.1007/s00167-020-06353-2 + 33165631 + + + + +
+ + + 36917243 + + 2023 + 03 + 14 + +
+ + 1432-1041 + + + 2023 + Mar + 14 + + + European journal of clinical pharmacology + Eur J Clin Pharmacol + + Increased major bleeding incidence in atrial fibrillation patients with apixaban: a review of Japanese post-marketing surveillance studies of direct oral anticoagulants. + 10.1007/s00228-023-03471-x + + Large-scaled post-marketing surveillance studies (PMSSs) of 4 direct oral anticoagulants (DOACs) for stroke prevention in non-valvular atrial fibrillation (AF) were conducted since 2011 in Japan, and the results of the last one have recently been published. Each reported a more than acceptable ischemic stroke prevention. The major bleeding rates were also acceptably low and comparable to each other in the PMSSs of dabigatran (J-dabigatran), rivaroxaban (XAPASS), and edoxaban (ETNA-AF-Japan). However, the incidence in PMSS of apixaban (STANDARD) was more than double the others. This finding appeared to contradict the globally accepted theory that apixaban is less likely than other DOACs to cause bleeding events. Possible responsible mechanisms included (1) the age and kidney function, (2) concomitant antiplatelet therapy, (3) drug actions, (4) follow-up duration, and (5) dose reduction criteria. Similarities in the clinical background shared by the 4 different PMSSs' participants and knowledge from previous studies did not support a dominant contribution of any of those former 4 factors to the increased major bleeding incidence in STANDARD. A possibility of the 5th factor was then examined. An estimated calculation we created showed that apixaban's dose reduction criteria was strict enough to considerably reduce the opportunity for participants to take its reduced rather than standard dose. We then successfully simulated how the "strict" dose reduction criteria would have increased the bleeding event rates under DOAC therapy. The discussion in this review may therefore raise a question about the validity of the current dose reduction criteria of apixaban for Japanese AF patients. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Sairaku + Akinori + A + + Department of Cardiology, Cardiovascular Center, National Hospital Organization Higashihiroshima Medical Center, 513 Jike, Saijo-cho, 739-0041, Higashihiroshima, Japan. rjrgw059@ybb.ne.jp. + + + Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan. rjrgw059@ybb.ne.jp. + + + + Nakano + Yukiko + Y + + Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan. + + + + eng + + Journal Article + Review + + + 2023 + 03 + 14 + +
+ + Germany + Eur J Clin Pharmacol + 1256165 + 0031-6970 + + IM + + Apixaban + Dose reduction criteria + Major bleeding + Post-marketing surveillance + +
+ + + + 2023 + 01 + 14 + + + 2023 + 02 + 27 + + + 2023 + 3 + 14 + 12 + 14 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917243 + 10.1007/s00228-023-03471-x + 10.1007/s00228-023-03471-x + + + + Connolly SJ, Ezekowitz MD, Yusuf S, Eikelboom J, Oldgren J, Parekh A, Pogue J, Reilly PA, Themeles E, Varrone J, Wang S, Alings M, Xavier D, Zhu J, Diaz R, Lewis BS, Darius H, Diener HC, Joyner CD, Wallentin L, RE-LY Steering Committee and Investigators (2009) Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 361:1139–1151 + + + Patel MR, Mahaffey KW, Garg J, Pan G, Singer DE, Hacke W, Breithardt G, Halperin JL, Hankey GJ, Piccini JP, Becker RC, Nessel CC, Paolini JF, Berkowitz SD, Fox KA, Califf RM,  ROCKET AF Investigators (2011) Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. 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Circulation 127:224–32 + + + Talmor-Barkan Y, Yacovzada NS, Rossman H, Witberg G, Kalka I, Kornowski R, Segal E (2022) Head-to-head efficacy and safety of rivaroxaban, apixaban, and dabigatran in an observational nationwide targeted trial. Eur Heart J Cardiovasc Pharmacother 9:26–37 + + + Frost C, Shenker A, Jhee S, Yu Z, Wang J, Bragat A, Pursley J, LaCreta F (2018) Evaluation of the single-dose pharmacokinetics and pharmacodynamics of apixaban in healthy Japanese and Caucasian subjects. Clin Pharmacol 10:153–163 + + + Testa S, Paoletti O, Legnani C, Dellanoce C, Antonucci E, Cosmi B, Pengo V, Poli D, Morandini R, Testa R, Tripodi A, Palareti G (2018) Low drug levels and thrombotic complications in high-risk atrial fibrillation patients treated with direct oral anticoagulants. 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+ + + 36917242 + + 2023 + 03 + 14 + +
+ + 1432-1912 + + + 2023 + Mar + 14 + + + Naunyn-Schmiedeberg's archives of pharmacology + Naunyn Schmiedebergs Arch Pharmacol + + The effects of curcumin and sertraline on stress-induced changes in the stomach tissues of rats. + 10.1007/s00210-023-02453-1 + + Exposure to stressors can cause functional disorders and structural damage to the stomach. Sertraline (SER) is an antidepressant and curcumin (CUR) is a natural compound with many properties. The current study aimed to investigate the impacts of stress, SER, and CUR on the stomach tissue using stereological methods. In total, 24 male and 24 female Sprague-Dawley rats were divided into four groups. In the control group, the rats were not exposed to stress. However, the animals in stress, SER and, CUR groups were exposed to daily stress and were orally fed with distilled water, SER (10 mg/kg/day), and CUR (100 mg/kg/day), respectively. The volume, surface area, and number of nerve, parietal, and chief cells were evaluated by stereological methods. Results showed that stress increased the stomach and its mucosa and submucosa volumes, while it decreased the surface area of the mucosa. Furthermore, this disorder increased the number of neurons in the submucosa and myenteric plexuses while it decreased the number of parietal and chief cells. However, treating stressed rats with SER or CUR could prevent these changes. The results showed that the consumption of SER or CUR could be used as a preventive or adjunctive treatment for stressful situations. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Owrang + Marzieh + M + + Histomorphometry and Stereology Research Center, Shiraz University of Medical Sciences, Zand Ave., Shiraz, 71348-45794, Iran. + + + + Noorafshan + Ali + A + + Histomorphometry and Stereology Research Center, Shiraz University of Medical Sciences, Zand Ave., Shiraz, 71348-45794, Iran. + + + Anatomy Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. + + + City University in Canada, 789 W Pender ST Suite 310, Vancouver, BC V6C 1H2, Canada. + + + + Rafati + Ali + A + + Histomorphometry and Stereology Research Center, Shiraz University of Medical Sciences, Zand Ave., Shiraz, 71348-45794, Iran. + + + Department of Physiology, Shiraz University of Medical Sciences, Shiraz, Iran. + + + + Karbalay-Doust + Saied + S + http://orcid.org/0000-0003-1071-1730 + + Histomorphometry and Stereology Research Center, Shiraz University of Medical Sciences, Zand Ave., Shiraz, 71348-45794, Iran. karbalas@sums.ac.ir. + + + Anatomy Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. karbalas@sums.ac.ir. + + + + eng + + + 97-01-01-18383 + Shiraz University of Medical Sciences + + + + 97-01-01-18383 + Shiraz University of Medical Sciences + + + + 97-01-01-18383 + Shiraz University of Medical Sciences + + + + 97-01-01-18383 + Shiraz University of Medical Sciences + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Naunyn Schmiedebergs Arch Pharmacol + 0326264 + 0028-1298 + + IM + + Curcumin + Rat + Sertraline + Stomach + Stress + +
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+ + 1432-086X + + + 2023 + Mar + 14 + + + Cardiovascular and interventional radiology + Cardiovasc Intervent Radiol + + How to Manage Spontaneous Retroperitoneal Haemorrhage. + 10.1007/s00270-023-03405-1 + + + Ierardi + Anna Maria + AM + http://orcid.org/0000-0002-3033-9713 + + Radiology Unit, IRCCS Ca Granda Ospedale Maggiore Policlinico, Via Sforza 35, 20122, Milan, Italy. amierardi@yahoo.it. + + + + Ascenti + Velio + V + + Postgraduate School of Radiology, University of Milan, Milan, Italy. + + + + Carrafiello + Gianpaolo + G + + Radiology Unit, IRCCS Ca Granda Ospedale Maggiore Policlinico, Via Sforza 35, 20122, Milan, Italy. + + + + eng + + Editorial + + + 2023 + 03 + 14 + +
+ + United States + Cardiovasc Intervent Radiol + 8003538 + 0174-1551 + + IM + + Conservative management + Embolization + SRH + Spontaneous retroperitoneal haemorrhage + +
+ + + + 2023 + 02 + 12 + + + 2023 + 02 + 23 + + + 2023 + 3 + 14 + 12 + 14 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917249 + 10.1007/s00270-023-03405-1 + 10.1007/s00270-023-03405-1 + + + + Lukies M, Gipson J, Tan SY, Clements W. Spontaneous retroperitoneal haemorrhage: efficacy of conservative management and embolisation. Cardiovasc Intervent Radiol. 2023. https://doi.org/10.1007/s00270-023-03359-4 . + + 10.1007/s00270-023-03359-4 + 36720738 + 9888734 + + + + Warren MH, Bhattacharya B, Maung AA, Davis KA. Contemporary management of spontaneous retroperitoneal and rectus sheath hematomas: management of spontaneous hematomas, In: Am J Surg, Elsevier Inc., 2020: pp. 707–710. https://doi.org/10.1016/j.amjsurg.2019.05.002 . + + + Klausenitz C, Kuehn JP, Noeckler K, Radosa CG, Hoffmann RT, Teichgraeber U, Mensel B. Efficacy of transarterial embolisation in patients with life-threatening spontaneous retroperitoneal haematoma. Clin Radiol. 2021;76(2):157.e11-157.e18. https://doi.org/10.1016/j.crad.2020.10.003 . (Epub 2020 Nov 1 PMID: 33138981). + + 10.1016/j.crad.2020.10.003 + 33138981 + + + + Grange R, Grange L, Chevalier C, Mayaud A, Villeneuve L, Boutet C, Grange S. Transarterial embolization for spontaneous soft-tissue hematomas: predictive factors for early death. J Pers Med. 2022;13(1):15. https://doi.org/10.3390/jpm13010015 . (PMID:36675676;PMCID:PMC9862993). + + 10.3390/jpm13010015 + 36675676 + 9862993 + + + + Barral M, Pellerin O, Tran VT, Gallix B, Boucher LM, Valenti D, Sapoval M, Soyer P, Dohan A. Predictors of mortality from spontaneous soft-tissue hematomas in a large multicenter cohort who underwent percutaneous transarterial embolization. Radiology. 2019;291(1):250–8. https://doi.org/10.1148/radiol.2018181187 . (Epub 2019 Jan 8 PMID: 30620252). + + 10.1148/radiol.2018181187 + 30620252 + + + + +
+ + + 36917251 + + 2023 + 03 + 14 + +
+ + 1434-4726 + + + 2023 + Mar + 14 + + + European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery + Eur Arch Otorhinolaryngol + + Subjective symptoms as predictors for eosinophilic chronic rhinosinusitis with nasal polyps in the Chinese population. + 10.1007/s00405-023-07905-1 + + To evaluate the putative association between subjective symptoms and eosinophilic inflammation in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). + A total of 102 patients with CRSwNP who underwent endoscopic sinus surgery were prospectively enrolled. The Sinonasal Outcomes Test-22 scores (SNOT-22), EuroQol 5-dimensional Questionnaire scores (ED-5D), and Lund-Mackay scores by computed tomography (CT) were obtained. Patients were grouped as eosinophilic CRSwNP (eCRSwNP) and non-eosinophilic CRSwNP (neCRSwNP). ECRSwNP was defined if tissue eosinophils of nasal polyps were greater than or equal to 8/HPF according to positive major basic protein (MBP) staining, and neCRSwNP otherwise. + Thirty neCRSwNP and 72 eCRSwNP patients were included. ECRSwNP patients had higher incidences of asthma (p = 0.001), allergic rhinitis (p = 0.001), and ethmoid-to-maxillary opacification ratio on CT scans (p < 0.001), whereas the proportion of purulent discharge (p < 0.001) and maxillary sinus score (p = 0.002) was higher in the neCRSwNP patients. There were no significant differences between patients on the mains of the EQ-5D health utility values and total SNOT-22 score. However, eCRSwNP patients had higher SNOT-22 scores of sneezing (p = 0.006), runny nose (p < 0.001), and ear/facial domain (p = 0.012), and lower scores of thick nasal discharge (p = 0.015) and blockage (p = 0.042). Sneezing, thick nasal discharge, and blockage/congestion of nose were recognized as independent factors of CRSwNP. + Sneezing was an independent predictor of eCRSwNP, and thick nasal discharge and blockage/congestion of nose were independent predictors of neCRSwNP. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Zhang + Chen + C + + ENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, 83 Fenyang Road, Shanghai, 200031, People's Republic of China. + + + + Wang + Huan + H + + ENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, 83 Fenyang Road, Shanghai, 200031, People's Republic of China. + + + + Zhang + Qianqian + Q + + ENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, 83 Fenyang Road, Shanghai, 200031, People's Republic of China. + + + + Chen + Jiani + J + + ENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, 83 Fenyang Road, Shanghai, 200031, People's Republic of China. + + + + Yu + Haoran + H + + ENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, 83 Fenyang Road, Shanghai, 200031, People's Republic of China. + + + + Li + Wangpeng + W + + ENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, 83 Fenyang Road, Shanghai, 200031, People's Republic of China. + + + + Xu + Haoyuan + H + + ENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, 83 Fenyang Road, Shanghai, 200031, People's Republic of China. + + + + Hu + Li + L + http://orcid.org/0000-0001-7221-7450 + + ENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, 83 Fenyang Road, Shanghai, 200031, People's Republic of China. hl318ent@163.com. + + + + Wang + Dehui + D + http://orcid.org/0000-0003-0346-3193 + + ENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, 83 Fenyang Road, Shanghai, 200031, People's Republic of China. wangdehuient@sina.com. + + + + Sun + Xicai + X + http://orcid.org/0000-0003-1423-0942 + + ENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, 83 Fenyang Road, Shanghai, 200031, People's Republic of China. laryngeal@163.com. + + + + eng + + + 21ZR1411700 + Natural Science Foundation of Shanghai + + + + 82000953 + National Natural Science Foundation of China + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Eur Arch Otorhinolaryngol + 9002937 + 0937-4477 + + IM + + Eosinophils + Nasal polyp + Quality of life + Rhinosinusitis + SNOT-22 + +
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+ + + 36917244 + + 2023 + 03 + 14 + +
+ + 1437-160X + + + 2023 + Mar + 14 + + + Rheumatology international + Rheumatol Int + + Burnout in South Asian rheumatologists in the COVID-19 pandemic: an online survey. + 10.1007/s00296-023-05304-7 + + Physician burnout is recognized as a global crisis and an epidemic. However, burnout in rheumatology is an understudied phenomenon. We explored the prevalence of physician burnout among rheumatologists from South Asia in the peri-pandemic period (2021-2022). Rheumatologists from Asian countries were invited to participate in an anonymized, validated, and pilot-tested e-survey via social media platforms from December 2021 to April 2022. Demographic information, social aspects (marital status, income, vacation time, daily exercise), substance abuse, EHR (electronic health record) use, and years in practice were obtained. In addition, burnout was estimated using Maslach Burnout Inventory-Human Services Survey for Medical Personnel (MBI-HSS) in three domains: emotional exhaustion (EE), depersonalization (DP), and personal accomplishment (PA), and intergroup comparisons were made using independent t test and one-way ANOVA using SPSS v27. Of 146 respondents who participated in the survey, 134 belonged to Asian nations. The highest number of respondents was from Pakistan (56/134, 38.36%), followed by India (49/134, 33.56%). Slightly more respondents were male, 75 (51.4%), than females, 71 (48.6%). Over two-thirds of our respondents (99/134, 67.8%) reported burnout in at least one domain. Notably, we found statistically significant increased depersonalization scores in males. (P < 0.05). Females scored significantly higher on the following items: #5 (I feel I treat some patients as if they were impersonal objects), item# 10 (I've become more insensitive toward people since I took this job and item#22 (I feel patients blame me for some of their problems) (P < 0.05). We found differences in monthly salaries among South Asian (1484 ± 2717 USD) and non-South Asian respondents (5672 ± 8874 USD) (P < 0.01). A substantial proportion of rheumatologists in our survey report burnout, suggesting a felt need to introduce organizational measures to prevent and mitigate burnout and preserve the rheumatology workforce. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Khursheed + Tayyeba + T + http://orcid.org/0000-0002-3083-4458 + + Department of Rheumatology, Pakistan Institute of Medical Sciences, Islamabad, Pakistan. pakrheum@gmail.com. + + + + Sharif + Muhammad + M + http://orcid.org/0000-0002-9273-3046 + + Department of Rheumatology, Pakistan Institute of Medical Sciences, Islamabad, Pakistan. + + + + Khan + Muhammad Sufyan + MS + http://orcid.org/0000-0003-1642-2227 + + Department of Rheumatology, Pakistan Institute of Medical Sciences, Islamabad, Pakistan. + + + + Masood + Ahmed + A + http://orcid.org/0000-0001-7039-3266 + + Department of Rheumatology, Pakistan Institute of Medical Sciences, Islamabad, Pakistan. + + + + Aziz + Wajahat + W + http://orcid.org/0000-0003-4070-0098 + + Department of Rheumatology, Pakistan Institute of Medical Sciences, Islamabad, Pakistan. + + + + Shah + Somaya + S + http://orcid.org/0000-0002-1671-3713 + + Department of Rheumatology, Pakistan Institute of Medical Sciences, Islamabad, Pakistan. + + + + Gupta + Latika + L + http://orcid.org/0000-0003-2753-2990 + + Department of Rheumatology, Royal Wolverhampton Hospitals NHS Trust, Wolverhampton, UK. + + + City Hospital, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK. + + + Division of Musculoskeletal and Dermatological Sciences, Centre for Musculoskeletal Research, School of Biological Sciences, The University of Manchester, Manchester, UK. + + + + Miraj + Muhammad Arqam + MA + http://orcid.org/0000-0003-0528-9694 + + Medical Student, Federal Medical Teaching Institute, Islamabad, Pakistan. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Rheumatol Int + 8206885 + 0172-8172 + + IM + + Asia + COVID-19 + Mental health + Occupational burnout + Pandemic + Professional burnout + Rheumatologists + South Asia + Surveys and questionnaires + +
+ + + + 2023 + 02 + 07 + + + 2023 + 03 + 01 + + + 2023 + 3 + 14 + 12 + 14 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917244 + 10.1007/s00296-023-05304-7 + 10.1007/s00296-023-05304-7 + + + + Organization WHO (2019) Burnout an "occupational phenomenon": international classification of diseases. World Health Organization. https://www.who.int/news/item/28-05-2019-burn-out-an-occupational-phenomenon-international-classification-of-diseases . Accessed 26 February 2023 + + + Ledikwe JH, Kleinman NJ, Mpho M, Mothibedi H, Mawandia S, Semo BW, O’Malley G (2018) Associations between healthcare worker participation in workplace wellness activities and job satisfaction, occupational stress and burnout: a cross-sectional study in Botswana. 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Lancet (London, England) 394(10193):93. https://doi.org/10.1016/s0140-6736(19)31573-9 + + 10.1016/s0140-6736(19)31573-9 + + + + Rotenstein LS, Torre M, Ramos MA, Rosales RC, Guille C, Sen S, Mata DA (2018) Prevalence of burnout among physicians: a systematic review. JAMA 320(11):1131–1150. https://doi.org/10.1001/jama.2018.12777 + + 10.1001/jama.2018.12777 + 30326495 + 6233645 + + + + Tiwari V, Kavanaugh A, Martin G, Bergman M (2020) High burden of burnout on rheumatology practitioners. J Rheumatol 47(12):1831–1834. https://doi.org/10.3899/jrheum.191110 + + 10.3899/jrheum.191110 + 32238512 + + + + Kulhawy-Wibe SC, Widdifield J, Lee JJY, Thorne JC, Yacyshyn EA, Batthish M, Jerome D, Shupak R, Jilkine K, Purvis J, Shamis J, Roberts J, Kur J, Burt JE, Johnson NA, Barnabe C, Hartfeld NMS, Harrison M, Pope JE, Barber CEH (2022) Results from the 2020 Canadian rheumatology association’s workforce and wellness survey. J Rheumatol 49(6):635–643. https://doi.org/10.3899/jrheum.210990 + + 10.3899/jrheum.210990 + 35105708 + + + + Intriago M, Maldonado G, Soriano E, Toro C, Moreno L, Ríos C (2022) Burnout in rheumatologists in Latin America. J Clin Rheumatol: Pract Rep Rheum Musculoskelet Dis 28(1):1–6. https://doi.org/10.1097/rhu.0000000000001795 + + 10.1097/rhu.0000000000001795 + + + + Manzano García G, Montañés Muro MP, López Megías J (2021) Does the economic crisis contribute to the burnout and engagement of Spanish nurses? Curr Psychol (New Brunswick, NJ). https://doi.org/10.1007/s12144-021-01527-8 + + 10.1007/s12144-021-01527-8 + + + + Kumar B, Swee ML, Suneja M, Iyer P (2021) Well-being burnout, and resiliency among early-career rheumatologists: a qualitative study. JCR: J Clin Rheumatol 27(8):e404–e411. https://doi.org/10.1097/rhu.0000000000001485 + + 10.1097/rhu.0000000000001485 + 32658045 + + + + McNearney TA, Hunnicutt SE, Maganti R, Rice J (2008) What factors relate to job satisfaction among rheumatologists? J Clin Rheumatol: Pract Rep Rheum Musculoskelet Dis 14(3):133–137. https://doi.org/10.1097/RHU.0b013e318177274d + + 10.1097/RHU.0b013e318177274d + + + + Pham CT, Lee CB, Nguyen TLH, Lin J-D, Ali S, Chu C (2020) Integrative settings approach to workplace health promotion to address contemporary challenges for worker health in the Asia-Pacific. Global Health Promot 27(2):82–90. https://doi.org/10.1177/1757975918816691 + + 10.1177/1757975918816691 + + + + Aggarwal A, Haq SA (2020) Rheumatology workforce issues in South Asia: challenges and solutions. Int J Rheum Dis 23(3):443–447. https://doi.org/10.1111/1756-185X.13793 + + 10.1111/1756-185X.13793 + 31960604 + + + + Gibson T (2014) Rheumatology in India and Pakistan today. Rheumatology 54(5):753–754. https://doi.org/10.1093/rheumatology/keu306%JRheumatology + + 10.1093/rheumatology/keu306%JRheumatology + 25102860 + + + + Khursheed T, Ovseiko PV, Harifi G, Badsha H, Cheng YK, Hill CL, Haq SA, Danda D, Gupta L (2022) Gender equity in rheumatology leadership in the Asia-Pacific. Rheumatol Adv Pract 6(3):rkac087. https://doi.org/10.1093/rap/rkac087 + + 10.1093/rap/rkac087 + 36382268 + 9642329 + + + + Maslach C, Jackson SE, Leiter MP (1997) Maslach burnout inventory. Scarecrow Education + + + Gaur PS, Zimba O, Agarwal V, Gupta L (2020) Reporting survey based studies - a primer for authors. J Korean Med Sci 35(45):e398–e398. https://doi.org/10.3346/jkms.2020.35.e398 + + 10.3346/jkms.2020.35.e398 + 33230988 + 7683244 + + + + West CP, Dyrbye LN, Shanafelt TD (2018) Physician burnout: contributors, consequences and solutions. J Intern Med 283(6):516–529. https://doi.org/10.1111/joim.12752 + + 10.1111/joim.12752 + 29505159 + + + + Melnikow J, Padovani A, Miller M (2022) Frontline physician burnout during the COVID-19 pandemic: national survey findings. BMC Health Serv Res 22(1):365. https://doi.org/10.1186/s12913-022-07728-6 + + 10.1186/s12913-022-07728-6 + 35303889 + 8933125 + + + + Kane LJMP (2022) Physician burnout and depression report 2022: stress, anxiety, and anger. + + + Kane LJNY, NY: Medscape (2021) Death by 1000 cuts': Medscape national physician burnout and suicide report 2021. + + + Ozyurt A, Hayran O, Sur H (2006) Predictors of burnout and job satisfaction among Turkish physicians. QJM: Int J Med 99(3):161–169. https://doi.org/10.1093/qjmed/hcl019 + + 10.1093/qjmed/hcl019 + + + + Lebares CC, Braun HJ, Guvva EV, Epel ES, Hecht FM (2018) Burnout and gender in surgical training: a call to re-evaluate coping and dysfunction. 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J Clin Psychiatry 72(5):605–614. https://doi.org/10.4088/JCP.10m06397gry + + 10.4088/JCP.10m06397gry + 21658347 + + + + Sandoval LR, Buckey JC, Ainslie R, Tombari M, Stone W, Hegel MT (2017) Randomized controlled trial of a computerized interactive media-based problem solving treatment for depression. Behav Ther 48(3):413–425. https://doi.org/10.1016/j.beth.2016.04.001 + + 10.1016/j.beth.2016.04.001 + 28390503 + + + + Workforce HH (2022) Health workforce resiliency awards. https://bhw.hrsa.gov/funding/health-workforce-resiliency-awards . Accessed 26 Feb 2023 + + + +
+ + + 36917246 + + 2023 + 03 + 14 + +
+ + 1433-7347 + + + 2023 + Mar + 14 + + + Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA + Knee Surg Sports Traumatol Arthrosc + + Quadriceps autograft is a viable graft choice for arthroscopic ACL reconstruction in patients over 50 years of age. + 10.1007/s00167-023-07367-2 + + The purpose of this study was to evaluate the patient-reported outcomes, graft failure, quadriceps rupture and sports preference after arthroscopic ACL reconstruction in patients older than 50 years who underwent arthroscopic ACL reconstruction with a quadriceps tendon (QT) autograft. + Between 2010 and 2020, prospectively collected data were obtained from an institutional database. Patients older than 50 years with primary arthroscopic ACL reconstruction and a minimum of 2 years of follow-up were included. Patients undergoing a revision ACL reconstruction or undergoing a primary ACL reconstruction using a graft other than a QT autograft, and patients with a contralateral knee injury or osteoarthritis (Ahlbäck stage 2 or higher) were excluded. A minimally invasive technique was used for QT autograft harvesting. Patients were evaluated for pre-injury and 2-year follow-up Lysholm knee score, Tegner activity level, Visual Analog Scale (VAS) for pain, graft failure, quadriceps tendon rupture, and return to sport. + A total of 57 patients were included in the study. The mean age of the cohort was 54.9 ± 5.2 (range 50-75). Of the 57 reconstructions, 16 (28%) were isolated ACL reconstructions, while 41 (72%) were complex reconstructions (concomitant meniscus, cartilage and/or collateral ligament injuries). At the 2-year follow-up Lysholm knee score, Tegner activity level and VAS for pain improved to pre-injury level and no significant difference was noted between pre-injury and 2-year follow-up functional scores (n.s.). No case of graft failure or quadriceps tendon rupture was reported. No significant difference was noted in the pre-injury and postoperative sports preference (n.s.) and all patients return to their desired sports activity. + Arthroscopic ACL reconstruction by using QT autograft in highly active older patients provides satisfactory patient-reported functional outcomes and allows recovery of the pre-injury level of activity. QT autograft is a good graft option in patients older than 50 years. + Level IV. + © 2023. The Author(s). + + + + Meena + Amit + A + + Gelenkpunkt - Sports and Joint Surgery, FIFA Medical Centre of Excellence, Olympiastraße 39, 6020, Innsbruck, Austria. + + + Research Unit for Orthopedic Sports Medicine and Injury Prevention (OSMI), Private University for Health Sciences, Medical Informatics and Technology, Innsbruck, Austria. + + + Fowler Kennedy Sport Medicine Clinic, Western University, London, ON, Canada. + + + + Farinelli + Luca + L + + Clinical Orthopedics, Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy. + + + + Hoser + Christian + C + + Gelenkpunkt - Sports and Joint Surgery, FIFA Medical Centre of Excellence, Olympiastraße 39, 6020, Innsbruck, Austria. + + + Research Unit for Orthopedic Sports Medicine and Injury Prevention (OSMI), Private University for Health Sciences, Medical Informatics and Technology, Innsbruck, Austria. + + + + Abermann + Elisabeth + E + + Gelenkpunkt - Sports and Joint Surgery, FIFA Medical Centre of Excellence, Olympiastraße 39, 6020, Innsbruck, Austria. + + + Research Unit for Orthopedic Sports Medicine and Injury Prevention (OSMI), Private University for Health Sciences, Medical Informatics and Technology, Innsbruck, Austria. + + + + Raj + Akshya + A + + Central Institute of Orthopedics, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, 110029, India. + + + + Hepperger + Caroline + C + + Gelenkpunkt - Sports and Joint Surgery, FIFA Medical Centre of Excellence, Olympiastraße 39, 6020, Innsbruck, Austria. + + + + Herbort + Mirco + M + + Research Unit for Orthopedic Sports Medicine and Injury Prevention (OSMI), Private University for Health Sciences, Medical Informatics and Technology, Innsbruck, Austria. + + + OCM Clinic, Munich, Germany. + + + + Fink + Christian + C + http://orcid.org/0000-0002-8446-2434 + + Gelenkpunkt - Sports and Joint Surgery, FIFA Medical Centre of Excellence, Olympiastraße 39, 6020, Innsbruck, Austria. c.fink@gelenkpunkt.com. + + + Research Unit for Orthopedic Sports Medicine and Injury Prevention (OSMI), Private University for Health Sciences, Medical Informatics and Technology, Innsbruck, Austria. c.fink@gelenkpunkt.com. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Knee Surg Sports Traumatol Arthrosc + 9314730 + 0942-2056 + + IM + + ACL + Anterior cruciate ligament + Functional outcome + Over 50 years + Quadriceps Graft + +
+ + + + 2022 + 09 + 05 + + + 2023 + 02 + 24 + + + 2023 + 3 + 14 + 12 + 14 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917246 + 10.1007/s00167-023-07367-2 + 10.1007/s00167-023-07367-2 + + + + Buerba RA, Boden SA, Lesniak B (2021) Graft selection in contemporary anterior cruciate ligament reconstruction. JAAOS Glob Res Rev. https://doi.org/10.5435/JAAOSGlobal-D-21-00230 + + 10.5435/JAAOSGlobal-D-21-00230 + + + + Cinque ME, Chahla J, Moatshe G, DePhillipo NN, Kennedy NI, Godin JA, LaPrade RF (2017) Outcomes and complication rates after primary anterior cruciate ligament reconstruction are similar in younger and older patients. Orthop J Sports Med 5:232596711772965 + + 10.1177/2325967117729659 + + + + Costa GG, Grassi A, Perelli S, Agrò G, Bozzi F, Lo Presti M, Zaffagnini S (2019) Age over 50 years is not a contraindication for anterior cruciate ligament reconstruction. Knee Surg Sports Traumatol Arthrosc 27:3679–3691 + + 10.1007/s00167-019-05450-1 + 30944945 + + + + Crum RJ, Kay J, Lesniak BP, Getgood A, Musahl V, de SA D (2021) Bone versus all soft tissue quadriceps tendon autografts for anterior cruciate ligament reconstruction: a systematic review. Arthroscopy 37:1040–1052 + + 10.1016/j.arthro.2020.10.018 + 33098947 + + + + Dahm DL, Wulf CA, Dajani KA, Dobbs RE, Levy BA, Stuart MA (2008) Reconstruction of the anterior cruciate ligament in patients over 50 years. J Bone Jt Surg Br 90-B:1446–1450 + + 10.1302/0301-620X.90B11.21210 + + + + D’Ambrosi R, Meena A, Raj A, Giorgino R, Ursino N, Mangiavini L, Karlsson J (2022) Good results after treatment of RAMP lesions in association with ACL reconstruction: a systematic review. Knee Surg Sports Traumatol Arthrosc. https://doi.org/10.1007/s00167-022-07067-3 + + 10.1007/s00167-022-07067-3 + 36534150 + 9898351 + + + + D’Ambrosi R, Meena A, Raj A, Ursino N, Formica M, Herbort M, Fink C (2022) Multiple revision anterior cruciate ligament reconstruction: not the best but still good. Knee Surg Sports Traumatol Arthrosc. https://doi.org/10.1007/s00167-022-07197-8 + + 10.1007/s00167-022-07197-8 + 36534150 + 9898351 + + + + Fayard J-M, Wein F, Ollivier M, Paihle R, Ehlinger M, Lustig S, Panisset J-C (2019) Factors affecting the outcome of ACL reconstruction in over-50-year-olds. Orthop Traumatol Surg Res 105:S247–S251 + + 10.1016/j.otsr.2019.09.011 + 31564634 + + + + Fink C, Lawton R, Förschner F, Gföller P, Herbort M, Hoser C (2018) Minimally invasive quadriceps tendon single-bundle, arthroscopic, anatomic anterior cruciate ligament reconstruction with rectangular bone tunnels. Arthrosc Tech 7:e1045–e1056 + + 10.1016/j.eats.2018.06.012 + 30377585 + 6203691 + + + + Firth AD, Bryant DM, Litchfield R, McCormack RG, Heard M, MacDonald PB et al (2022) Predictors of graft failure in young active patients undergoing hamstring autograft anterior cruciate ligament reconstruction with or without a lateral extra-articular tenodesis: the stability experience. Am J Sports Med 50:384–395 + + 10.1177/03635465211061150 + 35050817 + 8829733 + + + + Grassi A, Nitri M, Moulton SG, Marcheggiani Muccioli GM, Bondi A, Romagnoli M, Zaffagnini S (2017) Does the type of graft affect the outcome of revision anterior cruciate ligament reconstruction? A meta-analysis of 32 studies. Bone Jt J 99B:714–723 + + 10.1302/0301-620X.99B6.BJJ-2016-0929.R2 + + + + Hardy A, Casabianca L, Andrieu K, Baverel L, Noailles T (2017) Complications following harvesting of patellar tendon or hamstring tendon grafts for anterior cruciate ligament reconstruction: systematic review of literature. Orthop Traumatol Surg Res 103:S245–S248 + + 10.1016/j.otsr.2017.09.002 + 28888527 + + + + Herbort M, Michel P, Raschke MJ, Vogel N, Schulze M, Zoll A, Fink C, Petersen W, Domnick C (2017) Should the ipsilateral hamstrings be used for anterior cruciate ligament reconstruction in the case of medial collateral ligament insufficiency? Biomechanical investigation regarding dynamic stabilization of the medial compartment by the hamstring muscles. Am J Sports Med 45:819–825 + + 10.1177/0363546516677728 + 28029798 + + + + Iorio R, Iannotti F, Ponzo A, Proietti L, Redler A, Conteduca F, Ferretti A (2018) Anterior cruciate ligament reconstruction in patients older than fifty years: a comparison with a younger age group. Int Orthop 42:1043–1049 + + 10.1007/s00264-018-3860-8 + 29532113 + + + + Kim DK, Park G, Kuo L-T, Park WH (2019) Patients older than 50 years had similar results of knee strength and anteroposterior stability after ACL reconstruction compared to younger patients. Knee Surg Sports Traumatol Arthrosc 27:230–238 + + 10.1007/s00167-018-5342-3 + 30600340 + + + + Kim K-T, Kim H-J, Lee H-I, Park Y-J, Kang D-G, Yoo J-I, Moon D-K, Cho S-H, Hwang S-C (2018) A comparison of results after anterior cruciate ligament reconstruction in over 40 and under 40 years of age: a meta-analysis. Knee Surg Relat Res 30:95–106 + + 10.5792/ksrr.17.065 + 29843196 + 5990226 + + + + Lind M, Strauss MJ, Nielsen T, Engebretsen L (2021) Low surgical routine increases revision rates after quadriceps tendon autograft for anterior cruciate ligament reconstruction: results from the Danish knee ligament reconstruction registry. Knee Surg Sports Traumatol Arthrosc 29:1880–1886 + + 10.1007/s00167-020-06220-0 + 32886156 + + + + Mall NA, Frank RM, Saltzman BM, Cole BJ, Bach BR (2016) Results after anterior cruciate ligament reconstruction in patients older than 40 years: how do they compare with younger patients? A systematic review and comparison with younger populations. Sports Health 8:177–181 + + 10.1177/1941738115622138 + 26674619 + + + + Meena A, Farinelli L, Hoser C, Abermann E, Raj A, Hepperger C, Herbort M, Fink C (2022) Revision ACL reconstruction using quadriceps, hamstring and patellar tendon autografts leads to similar functional outcomes but hamstring graft has a higher tendency of graft failure. Knee Surg Sports Traumatol Arthrosc. https://doi.org/10.1007/s00167-022-07200-2 + + 10.1007/s00167-022-07200-2 + 36534150 + 9958158 + + + + Meena A, Hoser C, Abermann E, Hepperger C, Raj A, Fink C (2022) Total knee arthroplasty improves sports activity and the patient-reported functional outcome at mid-term follow-up. Knee Surg Sports Traumatol Arthrosc. https://doi.org/10.1007/s00167-022-07025-z + + 10.1007/s00167-022-07025-z + 36534150 + 9958158 + + + + Oliva F, Marsilio E, Migliorini F, Maffulli N (2021) Complex ruptures of the quadriceps tendon: a systematic review of surgical procedures and outcomes. J Orthop Surg 16:547 + + 10.1186/s13018-021-02696-9 + + + + Ovigue J, Bouguennec N, Graveleau N (2020) Arthroscopic anterior cruciate ligament reconstruction is a reliable option to treat knee instability in patients over 50 years old. Knee Surg Sports Traumatol Arthrosc 28:3686–3693 + + 10.1007/s00167-020-06254-4 + 32886155 + + + + Panisset J-C, Gonzalez J-F, de Lavigne C, Ode Q, Dejour D, Ehlinger M, Fayard J-M, Lustig S (2019) ACL reconstruction in over-50 year-olds: comparative study between prospective series of over-50 year-old and under-40 year-old patients. Orthop Traumatol Surg Res 105:S259–S265 + + 10.1016/j.otsr.2019.09.009 + 31648996 + + + + Runer A, Wierer G, Herbst E, Hepperger C, Herbort M, Gföller P, Hoser C, Fink C (2018) There is no difference between quadriceps- and hamstring tendon autografts in primary anterior cruciate ligament reconstruction: a 2-year patient-reported outcome study. Knee Surg Sports Traumatol Arthrosc 26:605–614 + + 10.1007/s00167-017-4554-2 + 28477270 + + + + Salesky MA, Oeding JF, Zhang AL, Ma CB, Feeley BT, Lansdown DA (2021) Patients aged 50 years and older have greater complication rates after anterior cruciate ligament reconstruction: a large database study. Arthrosc Sports Med Rehabil 3:e1827–e1834 + + 10.1016/j.asmr.2021.08.010 + 34977637 + 8689249 + + + + Singh A, Wei DT, Lin CTP, Liang S, Goyal S, Tan K-A, Chin BZ, Krishna L (2017) Concomitant meniscal injury in anterior cruciate ligament reconstruction does not lead to poorer short-term post-operative outcomes. Knee Surg Sports Traumatol Arthrosc. https://doi.org/10.1007/s00167-017-4635-2 + + 10.1007/s00167-017-4635-2 + 28712027 + + + + Tan C-W, Hsu W-H, Yu P-A, Chen C-L, Kuo L-T, Chi C-C, Kim D, Park G (2020) Anterior cruciate ligament reconstruction in patients older than 50 years: a systematic review and meta-analysis. Orthop J Sports Med 8:232596712091569 + + 10.1177/2325967120915698 + + + + Thorolfsson B, Svantesson E, Snaebjornsson T, Sansone M, Karlsson J, Samuelsson K, Senorski EH (2021) Adolescents have twice the revision rate of young adults after ACL reconstruction with hamstring tendon autograft: a study from the Swedish national knee ligament Registry. Orthop J Sports Med 9:232596712110388 + + 10.1177/23259671211038893 + + + + Toanen C, Demey G, Ntagiopoulos PG, Ferrua P, Dejour D (2017) Is there any benefit in anterior cruciate ligament reconstruction in patients older than 60 years? Am J Sports Med 45:832–837 + + 10.1177/0363546516678723 + 28056178 + + + + Wierer G, Herbst E, Hoser C, Gföller P, Fink C (2017) High rate of return to activity after ACL reconstruction in patients over 40 years of age: a systematic review. J ISAKOS 2:200–204 + + 10.1136/jisakos-2016-000085 + + + + Winkler PW, Vivacqua T, Thomassen S, Lovse L, Lesniak BP, Getgood AMJ, Musahl V (2022) Quadriceps tendon autograft is becoming increasingly popular in revision ACL reconstruction. Knee Surg Sports Traumatol Arthrosc 30:149–160 + + 10.1007/s00167-021-06478-y + 33591370 + + + + Yagnik G (2020) A systematic review of anterior cruciate ligament reconstructions with hamstring autograft in patients over 50 years of age. Orthop Sports Med Open Access J. https://doi.org/10.32474/OSMOAJ.2020.04.000193 + + 10.32474/OSMOAJ.2020.04.000193 + + + + +
+ + + 36917237 + + 2023 + 03 + 14 + +
+ + 2333-0376 + + 37 + 1 + + 2023 Winter + + + Journal of oral & facial pain and headache + J Oral Facial Pain Headache + + A Meta-Synthesis of the Experience of Chronic Temporomandibular Disorder Patients Within Health Care Services. + + 57-75 + + 10.11607/ofph.3112 + + Aims: To systematically review the qualitative evidence related to experiences of patients with temporomandibular disorders (TMD) and to explore their journeys within health care services. Methods: A systematic search of the following databases was conducted: MEDLINE, Embase, PsycINFO, Web of Science, CINAHL Complete, and the Cochrane database. Thematic synthesis was used to analyze and synthesize the data from qualitative studies that explored the journeys of TMD patients within health care services. The Critical Appraisal Skills Programme (CASP) tool was used to critically appraise the quality of the included studies. Results: The search strategies yielded 4,563 articles across all databases, and 18 articles were eventually included. Six themes were derived: care-seeking attitudes; expectations and health care experience; the patient-clinician interaction; diagnosis as a stepping stone for improvement; management; and social support. Conclusion: The journey within health care services may play a valuable role in the ability to cope with chronic TMDs. Receiving a diagnosis, being listened to, and being believed are among the most important elements making for a positive clinical experience. + + + + Taimeh + Dina + D + + + Leeson + Rachel + R + + + Fedele + Stefano + S + + + Riordain + Richeal Ni + RN + + + eng + + Journal Article + +
+ + United States + J Oral Facial Pain Headache + 101624698 + +
+ + + + 2023 + 3 + 14 + 12 + 13 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + ppublish + + 36917237 + 10.11607/ofph.3112 + + +
+ + + 36917253 + + 2023 + 03 + 14 + +
+ + 1944-8252 + + + 2023 + Mar + 14 + + + ACS applied materials & interfaces + ACS Appl Mater Interfaces + + Turbostratic Lattice and Electronegativity Modification Jointly Enabled an Ultra-High-Rate and Long-Lived Carbon Anode for Potassium-Ion Batteries. + 10.1021/acsami.3c00912 + + Potassium-ion batteries (PIBs) are considered as a promising technology alternative to lithium-ion batteries due to more abundance of potassium than lithium and a lower redox potential of K/K+ than that of Na/Na+. The critical limitation in PIBs is the electrode with poor rate capability and cycling stability induced by the sluggish reaction kinetics and large volume change during potassiation and depotassiation. In this work, we report a turbostratic lattice iodine-doped carbon (TLIC) nanosheet as an advanced innovative anode for PIBs displaying fast charge/discharge and electrode stability. The turbostratic lattice caused by doping of large-sized iodine and the unique charge transfer between iodine/carbon atoms creates more active sites and a shorter transport distance for K ions, improves the electrochemical activity, promotes rapid ion diffusion, and enhances pseudocapacitive behavior. The TLIC exhibits a high capacity of 433.5 mAh g-1 at 50 mA g-1, an ultrahigh rate capability of 162.1 mAh g-1 at 20 A g-1, and an excellent capacity retention of ∼96% (206 mAh g-1) after 4000 cycles. The combination of turbostratic lattice and pseudocapactive storage is an effective approach to designing carbon electrodes with the transformational performance of high capacity, rate performance, and long lifetime for practical applications of PIBs. + + + + Wang + Dong + D + + Tianjin Key Laboratory of Brine Chemical Engineering and Resource Eco-Utilization, Tianjin University of Science & Technology, Tianjin 300457, China. + + + + Lian + Jie + J + 0000-0002-9060-8831 + + Department of Mechanical, Aerospace, and Nuclear Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180, United States. + + + + Wang + Yuanzhe + Y + + Tianjin Key Laboratory of Brine Chemical Engineering and Resource Eco-Utilization, Tianjin University of Science & Technology, Tianjin 300457, China. + + + + Jia + Peng + P + + Key Laboratory of Applied Chemistry, College of Environmental and Chemical Engineering, Yanshan University, No. 438 Hebei Street, Qinhuangdao 066004, China. + + + + Gao + Faming + F + 0000-0003-3624-7200 + + Tianjin Key Laboratory of Brine Chemical Engineering and Resource Eco-Utilization, Tianjin University of Science & Technology, Tianjin 300457, China. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + ACS Appl Mater Interfaces + 101504991 + 1944-8244 + + IM + + DFT calculation + doping + electronegativity modification + iodine + turbostratic lattice + +
+ + + + 2023 + 3 + 14 + 12 + 14 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917253 + 10.1021/acsami.3c00912 + + +
+ + + 36917250 + + 2023 + 03 + 14 + +
+ + 1432-069X + + + 2023 + Mar + 14 + + + Archives of dermatological research + Arch Dermatol Res + + Atopic dermatitis is associated with abnormal stool form: a population-based cross-sectional study in college students. + 10.1007/s00403-023-02567-9 + + Atopic dermatitis (AD) is a chronic inflammatory skin disorder. Bristol Stool Form Scale (BSFS) is a widely used stool scoring method that could indirectly reflect intestinal function. + To evaluate the associations of AD with BSFS. + This was a population-based cross-sectional study of freshmen in five universities of China. AD diagnosis was performed by dermatologists according to the guideline from the American Academy of Dermatology. BSFS and covariates were collected through an online questionnaire survey. Chronic itch scores were assessed by the numeric rating scales and grouped into quartiles (Q). Mixed logistic regression models were used. Subgroup analysis was conducted by covariates. P value < 0.05 was considered statistically significant. + The prevalence of hard stools and loose stools were 8.9% and 7.6%, respectively (20,049 participants). After adjusting covariates, AD was significantly associated with hard stools (OR = 1.38, P < 0.001) and loose stools (OR = 1.24, P = 0.037). In subgroup analysis of hard stool, a stronger effect was observed in intake of milk (> 3 days/week), yogurt (> 3 days/week), pork (< 1 day/week), and higher itch scores (Q4). + This study found the relationship between AD and abnormal stool forms, and the association with hard stools might be modified by dietary factor. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Su + Juan + J + + Department of Dermatology, Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, 110 Xiangya Road, Changsha, 410008, Hunan, China. + + + National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha, China. + + + + Gu + Xiaoyu + X + + Department of Dermatology, Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, 110 Xiangya Road, Changsha, 410008, Hunan, China. + + + National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha, China. + + + + Li + Ji + J + + Department of Dermatology, Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, 110 Xiangya Road, Changsha, 410008, Hunan, China. + + + + Tao + Juan + J + + Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. + + + + Kang + Xiaojing + X + + Department of Dermatology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumchi, Xinjiang, China. + + + + Wu + Bin + B + + Department of Dermatology, The Affiliated People's Hospital of Inner Mongolia Medical University, Hohhot, China. + + + + Shan + Shijun + S + + Department of Dermatology, Xiang'an Hospital, Xiamen University, Xiamen, China. + + + + Ang + Xiaohui + X + + Department of Dermatology, Zhongshan Hospital, Xiamen University, Xiamen, China. + + + + Chen + Xiang + X + + Department of Dermatology, Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, 110 Xiangya Road, Changsha, 410008, Hunan, China. chenxiangck@126.com. + + + National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha, China. chenxiangck@126.com. + + + + Xiao + Yi + Y + + Department of Dermatology, Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, 110 Xiangya Road, Changsha, 410008, Hunan, China. xiaoyixy@csu.edu.cn. + + + + Shen + Minxue + M + + Department of Dermatology, Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, 110 Xiangya Road, Changsha, 410008, Hunan, China. shenmx1988@csu.edu.cn. + + + National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha, China. shenmx1988@csu.edu.cn. + + + Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha, China. shenmx1988@csu.edu.cn. + + + + eng + + + 2016YFC0900802 + National Key Research and Development Project of China "Precision Medicine Initiative" + + + + 2016YFC0900802 + National Key Research and Development Project of China "Precision Medicine Initiative" + + + + TC210804V + Project of Intelligent Management Software for Multimodal Medical Big Data for New Generation Information Technology, Ministry of Industry and Information Technology of People's Republic of China + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Arch Dermatol Res + 8000462 + 0340-3696 + + IM + + Atopic dermatitis + College student + Prevalence + Stool form + +
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Inflamm Bowel Dis 28(2):e27–e28 + + 10.1093/ibd/izab240 + 34591962 + + + + Kaya İslamoğlu ZG, Unal M, Küçük A (2019) Atopic dermatitis in adults and irritable bowel syndrome: a cross-sectional study. Indian J Dermatol 64(5):355–359 + + 10.4103/ijd.IJD_490_18 + 31543528 + 6749755 + + + + Gilaberte Y, Pérez-Gilaberte JB, Poblador-Plou B et al (2020) Prevalence and comorbidity of atopic dermatitis in children: a large-scale population study based on real-world data. J Clin Med 9(6):1632 + + 10.3390/jcm9061632 + 32481591 + 7356227 + + + + Tsai JD, Wang IC, Shen TC et al (2018) A 8-year population-based cohort study of irritable bowel syndrome in childhood with history of atopic dermatitis. J Investig Med 66(4):755–761 + + 10.1136/jim-2017-000631 + 29374025 + + + + Xiao H, Gu X, Huang Y et al (2021) Phototherapy for atopic dermatitis: Systematic review and network meta-analysis of randomized controlled trials. 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Aliment Pharmacol Ther 44(7):693–703 + + 10.1111/apt.13746 + 27492648 + + + + Fang Z, Li L, Zhang H et al (2021) Gut microbiota, probiotics, and their interactions in prevention and treatment of atopic dermatitis: a review. Front Immunol 12:720393 + + 10.3389/fimmu.2021.720393 + 34335634 + 8317022 + + + + Leyva-Castillo JM, Galand C, Kam C et al (2019) Mechanical skin injury promotes food anaphylaxis by driving intestinal mast cell expansion. Immunity 50(5):1262–1275 (e4) + + 10.1016/j.immuni.2019.03.023 + 31027995 + 6531322 + + + + Gu X, Su J, Tao J et al (2022) Characterization of chronic itch in college students in China. Eur J Dermatol 32(1):64–69 + + 10.1684/ejd.2022.4193 + 35171797 + + + + Shen M, Gu X, Li S et al (2021) Exposure to black carbon is associated with symptoms of depression: a retrospective cohort study in college students. Environ Int 157:106870 + + 10.1016/j.envint.2021.106870 + 34534788 + + + + Li Y, Su J, Luo D et al (2021) Processed food and atopic dermatitis: a pooled analysis of three cross-sectional studies in chinese adults. Front Nutr 8:754663 + + 10.3389/fnut.2021.754663 + 34938758 + 8685501 + + + + Eichenfield LF, Tom WL, Chamlin SL et al (2014) Guidelines of care for the management of atopic dermatitis: sect ion 1. Diagnosis and assessment of atopic dermatitis. J Am Acad Dermatol 70(2):338–351 + + 10.1016/j.jaad.2013.10.010 + 24290431 + + + + Arck P, Handjiski B, Hagen E et al (2010) Is there a ‘gut-brain-skin axis’? Exp Dermatol 19:401–405 + + 10.1111/j.1600-0625.2009.01060.x + 20113345 + + + + Galazzo G, Van Best N, Bervoets L et al (2020) Development of the microbiota and associations with birth mode, diet, and atopic disorders in a longitudinal analysis of stool samples, collected from infancy through early childhood. 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+ + + 36917245 + + 2023 + 03 + 14 + +
+ + 1432-0886 + + + 2023 + Mar + 14 + + + Chromosoma + Chromosoma + + Are extraordinary nucleosome structures more ordinary than we thought? + 10.1007/s00412-023-00791-w + + The nucleosome is a DNA-protein assembly that is the basic unit of chromatin. A nucleosome can adopt various structures. In the canonical nucleosome structure, 145-147 bp of DNA is wrapped around a histone heterooctamer. The strong histone-DNA interactions cause the DNA to be inaccessible for nuclear processes such as transcription. Therefore, the canonical nucleosome structure has to be altered into different, non-canonical structures to increase DNA accessibility. While it is recognised that non-canonical structures do exist, these structures are not well understood. In this review, we discuss both the evidence for various non-canonical nucleosome structures in the nucleus and the factors that are believed to induce these structures. The wide range of non-canonical structures is likely to regulate the amount of accessible DNA, and thus have important nuclear functions. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Chong + Claris Y Y + CYY + http://orcid.org/0000-0002-7785-179X + + Department of Biological Sciences and Centre for BioImaging Sciences, National University of Singapore, Singapore, 117543, Singapore. + + + + Gan + Lu + L + http://orcid.org/0000-0002-8685-4896 + + Department of Biological Sciences and Centre for BioImaging Sciences, National University of Singapore, Singapore, 117543, Singapore. lu@anaphase.org. + + + + eng + + + MOE2019-T2-1-140 + Ministry of Education - Singapore + + + + MOE2019-T2-1-140 + Ministry of Education - Singapore + + + + + Journal Article + Review + + + 2023 + 03 + 14 + +
+ + Austria + Chromosoma + 2985138R + 0009-5915 + + IM + + Chromatin + Cryo-ET + Nucleosome + Transcription + +
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+ + 1420-9071 + + 80 + 4 + + 2023 + Mar + 14 + + + Cellular and molecular life sciences : CMLS + Cell Mol Life Sci + + A Rab10-ACAP1-Arf6 GTPases cascade modulates M4 muscarinic acetylcholine receptor trafficking and signaling. + + 87 + + 10.1007/s00018-023-04722-x + + Membrane trafficking processes regulate the G protein-coupled receptor activity. The muscarinic acetylcholine receptors (mAChRs) are highly pursued drug targets for neurological diseases, but the cellular machineries that control the trafficking of these receptors remain largely elusive. Here, we revealed the role of the small GTPase Rab10 as a negative regulator for the post-activation trafficking of M4 mAChR and the underlying mechanism. We show that constitutively active Rab10 arrests the receptor within Rab5-positive early endosomes and significantly hinders the resensitization of M4-mediated Ca2+ signaling. Mechanistically, M4 binds to Rab10-GTP, which requires the motif 386RKKRQMAA393 (R386-A393) within the third intracellular loop. Moreover, Rab10-GTP inactivates Arf6 by recruiting the Arf6 GTPase-activating protein, ACAP1. Strikingly, deletion of the motif R386-A393 causes M4 to bypass the control by Rab10 and switch to the Rab4-facilitated fast recycling pathway, thus reusing the receptor. Therefore, Rab10 couples the cargo sorting and membrane trafficking regulation through cycle between GTP-bound and GDP-bound state. Our findings suggest a model that Rab10 binds to the M4 like a molecular brake and controls the receptor's transport through endosomes, thus modulating the signaling, and this regulation is specific among the mAChR subtypes. + © 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG. + + + + Xu + Rongmei + R + + Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China. + + + + Wan + Min + M + + Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China. + + + Department of Molecular Biology and Genetics, Cornell University, Ithaca, USA. + + + + Shi + Xuemeng + X + + Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China. + + + College of Life Science, Henan Agricultural University, Zhengzhou, Henan, China. + + + + Ma + Shumin + S + + Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China. + + + + Zhang + Lina + L + + Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China. + + + + Yi + Ping + P + + Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China. pingy@hust.edu.cn. + + + + Zhang + Rongying + R + http://orcid.org/0000-0001-8969-5088 + + Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China. ryzhang@mail.hust.edu.cn. + + + + eng + + + 91954107 + Major Research Plan + + + + 32270739 + National Natural Science Foundation of China + + + + 31571468 + National Natural Science Foundation of China + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + Switzerland + Cell Mol Life Sci + 9705402 + 1420-682X + + IM + + Endosomal recycling + GPCR + Muscarinic acetylcholine receptors + Protein sorting + Rab4 + Signaling + +
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Curr Biol 28:R471–R486. https://doi.org/10.1016/j.cub.2018.02.010 + + 10.1016/j.cub.2018.02.010 + 29689231 + 5965285 + + + + Zhang X, Huang TY, Yancey J, Luo H, Zhang YW (2019) Role of Rab GTPases in Alzheimer’s disease. ACS Chem Neurosci 10:828–838. https://doi.org/10.1021/acschemneuro.8b00387 + + 10.1021/acschemneuro.8b00387 + 30261139 + + + + +
+ + + 36917258 + + 2023 + 03 + 14 + +
+ + 1433-3023 + + + 2023 + Mar + 14 + + + International urogynecology journal + Int Urogynecol J + + Association between vaginal or cesarean delivery and later development of stress urinary incontinence or pelvic organ prolapse: A retrospective population-based cohort study. + 10.1007/s00192-023-05504-6 + + Child delivery mode may be associated with pelvic floor disorders. We explored the association between different delivery modes and later development of stress urinary incontinence (SUI) and pelvic organ prolapse (POP) in Taiwanese women. + This was a retrospective population-based cohort study. Women who delivered babies between January 1, 2000, and December 31, 2018, were selected for this study. The study used Taiwan's National Health Insurance (NHI) Research Database. After propensity score matching, 51,587 women who underwent cesarean section (C/S) and 51,587 women who underwent vaginal delivery (VD) were recruited. Primary outcomes were the presence of SUI and POP after delivery. + The incidence of SUI (1.6/1000 person-years) and POP (1.5/1000 person-years) was higher in the VD group than in the C/S group (0.8 and 0.6 in 1000 person-years). VD was associated with an increased risk of SUI [hazard ratio (HR): 2.79, 95% confidence interval (CI): 2.45-3.17] and POP (HR: 1.96, 95% CI: 1.75-2.19) compared to C/S. We also found that age (HR: 1.06, 95% CI: 1.05-1.08 in SUI, HR: 1.08, 95% CI: 1.07-1.09 in POP) and Charlson Comorbidity Index (CCI) (HR: 1.28, 95% CI: 1.12-1.46 in SUI, HR: 1.27, 95% CI: 1.13-1.43 in POP) were associated with an increased risk of SUI and POP. The cumulative incidence of SUI and POP was higher in the VD group than in the C/S group (log-rank test, P < 0.05). + The current study was the largest retrospective cohort study regarding the influence of delivery mode on SUI and POP so far. VD was found to be associated with an increased risk of SUI and POP compared with C/S. Postpartum care for pelvic physical therapy should be provided particularly to women undergoing VD. + © 2023. The International Urogynecological Association. + + + + Tsui + Wing Lam + WL + + Department of Obstetrics and Gynecology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, Hualien, 970, Taiwan. + + + + Deng + Guang-Hong + GH + + Tzu Chi University Research Center for Big Data Teaching, Research and Statistic Consultation, Tzu Chi University, Hualien, 970, Taiwan. + + + + Hsieh + Tsung-Cheng + TC + + Tzu Chi University Research Center for Big Data Teaching, Research and Statistic Consultation, Tzu Chi University, Hualien, 970, Taiwan. + + + Institute of Medical Sciences, Tzu Chi University, Hualien, 970, Taiwan. + + + + Ding + Dah-Ching + DC + http://orcid.org/0000-0001-5105-068X + + Department of Obstetrics and Gynecology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, Hualien, 970, Taiwan. dah1003@yahoo.com.tw. + + + Institute of Medical Sciences, Tzu Chi University, Hualien, 970, Taiwan. dah1003@yahoo.com.tw. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + England + Int Urogynecol J + 101567041 + 0937-3462 + + IM + + Cesarean delivery + Pelvic organ prolapse + Prognosis + Stress urinary incontinence + Vaginal delivery + +
+ + + + 2022 + 11 + 25 + + + 2023 + 02 + 14 + + + 2023 + 3 + 14 + 12 + 14 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917258 + 10.1007/s00192-023-05504-6 + 10.1007/s00192-023-05504-6 + + + + Aoki Y, Brown HW, Brubaker L, et al. Urinary incontinence in women. Nat Rev Dis Primers. 2017;3:17042. + + 10.1038/nrdp.2017.42 + 28681849 + 5878864 + + + + Bedretdinova D, Fritel X, Panjo H, Ringa V. Prevalence of female urinary incontinence in the general population according to different definitions and study designs. Eur Urol. 2016;69:256–64. + + 10.1016/j.eururo.2015.07.043 + 26259998 + + + + Haylen BT, de Ridder D, Freeman RM, et al. An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint report on the terminology for female pelvic floor dysfunction. Neurourol Urodyn. 2010;29:4–20. + + 10.1002/nau.20798 + 19941278 + + + + Luber KM. The definition, prevalence, and risk factors for stress urinary incontinence. Rev Urol. 2004;6(Suppl 3):S3-9. + + 16985863 + 1472862 + + + + Gyhagen M, Åkervall S, Molin M, Milsom I. The effect of childbirth on urinary incontinence: a matched cohort study in women aged 40–64 years. Am J Obstet Gynecol. 2019;221:322.e1-322.e17. + + 10.1016/j.ajog.2019.05.022 + 31121136 + + + + Scarpa KP, Herrmann V, Palma PCR, et al. Prevalence and correlates of stress urinary incontinence during pregnancy: a survey at UNICAMP Medical School, São Paulo, Brazil. Int Urogynecol J Pelvic Floor Dysfunct. 2006;17:219–23. + + 10.1007/s00192-005-1361-y + 16021326 + + + + Barber MD, Maher C. Epidemiology and outcome assessment of pelvic organ prolapse. Int Urogynecol J. 2013;24:1783–90. + + 10.1007/s00192-013-2169-9 + 24142054 + + + + Yuk J-S, Lee JH, Hur J-Y, Shin J-H. The prevalence and treatment pattern of clinically diagnosed pelvic organ prolapse: a Korean National Health Insurance Database-based cross-sectional study 2009–2015. Sci Rep. 2018;8:1334. + + 10.1038/s41598-018-19692-5 + 29358718 + 5778022 + + + + Koc O, Duran B. Role of elective cesarean section in prevention of pelvic floor disorders. Curr Opin Obstet Gynecol. 2012;24:318–23. + + 10.1097/GCO.0b013e3283573fcb + 22814811 + + + + Hutton EK, Hannah ME, Willan AR, et al. Urinary stress incontinence and other maternal outcomes 2 years after caesarean or vaginal birth for twin pregnancy: a multicentre randomised trial. BJOG. 2018;125:1682–90. + + 10.1111/1471-0528.15407 + 30007113 + 6282843 + + + + Tähtinen RM, Cartwright R, Tsui JF, et al. Long-term impact of mode of delivery on stress urinary incontinence and urgency urinary incontinence: a systematic review and meta-analysis. Eur Urol. 2016;70:148–58. + + 10.1016/j.eururo.2016.01.037 + 26874810 + 5009182 + + + + Jansson MH, Franzén K, Tegerstedt G, et al. Stress and urgency urinary incontinence one year after a first birth-prevalence and risk factors. A prospective cohort study. Acta Obstet Gynecol Scand. 2021;100:2193–201. + + 10.1111/aogs.14275 + 34699060 + + + + Aytan H, Ertunç D, Tok EC, et al. Prevalence of pelvic organ prolapse and related factors in a general female population. Turk J Obstet Gynecol. 2014;11:176–80. + + 10.4274/tjod.90582 + 28913013 + 5558330 + + + + Weintraub AY, Glinter H, Marcus-Braun N. Narrative review of the epidemiology, diagnosis and pathophysiology of pelvic organ prolapse. Int Braz J Urol. 2020;46:5–14. + + 10.1590/s1677-5538.ibju.2018.0581 + 31851453 + 6968909 + + + + Lin Y-H, Chang S-D, Hsieh W-C, et al. Persistent stress urinary incontinence during pregnancy and one year after delivery; its prevalence, risk factors and impact on quality of life in Taiwanese women: An observational cohort study. Taiwan J Obstet Gynecol. 2018;57:340–5. + + 10.1016/j.tjog.2018.04.003 + 29880161 + + + + Gorodeski IG, Bahari CM, Schachter A, Neri A. Abruption and premature separation of placenta previa. Eur J Obstet Gynecol Reprod Biol. 1982;13:75–85. + + 10.1016/0028-2243(82)90003-X + 7084550 + + + + Macheku GS, Philemon RN, Oneko O, et al. Frequency, risk factors and feto-maternal outcomes of abruptio placentae in Northern Tanzania: a registry-based retrospective cohort study. BMC Pregnancy Childbirth. 2015;15:242. + + 10.1186/s12884-015-0678-x + 26446879 + 4597387 + + + + Mourgues J, Villot A, Thubert T, et al. Uterine myomas and lower urinary tract dysfunctions: a literature review. J Gynecol Obstet Hum Reprod. 2019;48:771–4. + + 10.1016/j.jogoh.2019.03.021 + 30905852 + + + + Tsai Y-C, Liu C-H. Urinary incontinence among Taiwanese women: an outpatient study of prevalence, comorbidity, risk factors, and quality of life. Int Urol Nephrol. 2009;41:795–803. + + 10.1007/s11255-009-9523-3 + 19199071 + + + + Glasheen WP, Cordier T, Gumpina R, et al. Charlson comorbidity index: ICD-9 update and ICD-10 translation. Am Health Drug Benefits. 2019;12:188–97. + + 31428236 + 6684052 + + + + Betran AP, Ye J, Moller A-B, et al. Trends and projections of caesarean section rates: global and regional estimates. BMJ Glob Health. 2021;6:e005671. https://doi.org/10.1136/bmjgh-2021-005671 . + + 10.1136/bmjgh-2021-005671 + 34130991 + 8208001 + + + + Barca JA, Bravo C, Pintado-Recarte MP, et al. Pelvic floor morbidity following vaginal delivery versus cesarean delivery: systematic review and meta-analysis. J Clin Med Res. 2021;10:1652. https://doi.org/10.3390/jcm10081652 . + + 10.3390/jcm10081652 + + + + Gurol-Urganci I, Cromwell DA, Edozien LC, et al. Risk of placenta previa in second birth after first birth cesarean section: a population-based study and meta-analysis. BMC Pregnancy Childbirth. 2011;11:95. + + 10.1186/1471-2393-11-95 + 22103697 + 3247856 + + + + Rortveit G, Daltveit AK, Hannestad YS, et al. Urinary incontinence after vaginal delivery or cesarean section. N Engl J Med. 2003;348:900–7. + + 10.1056/NEJMoa021788 + 12621134 + + + + Buchsbaum GM, Duecy EE, Kerr LA, et al. Urinary incontinence in nulliparous women and their parous sisters. Obstet Gynecol. 2005;106:1253–8. + + 10.1097/01.AOG.0000187309.46650.b2 + 16319249 + + + + Blomquist JL, Muñoz A, Carroll M, Handa VL. Association of delivery mode with pelvic floor disorders after childbirth. JAMA. 2018;320:2438–47. + + 10.1001/jama.2018.18315 + 30561480 + 6583632 + + + + Volløyhaug I, Mørkved S, Salvesen Ø, Salvesen KÅ. Forceps delivery is associated with increased risk of pelvic organ prolapse and muscle trauma: a cross-sectional study 16–24 years after first delivery. Ultrasound Obstet Gynecol. 2015;46:487–95. + + 10.1002/uog.14891 + 25920322 + + + + Zhu Y-C, Deng S-H, Jiang Q, Zhang Y. Correlation between delivery mode and pelvic organ prolapse evaluated by four-dimensional pelvic floor ultrasonography. 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Risk factors for urgency incontinence in women undergoing stress urinary incontinence surgery. Adv Urol. 2013;2013: 567375. + + 10.1155/2013/567375 + 24307896 + 3838812 + + + + Chughtai B, Thomas D, Russell D, et al. Prevalence of and risk factors for urinary incontinence in home hospice patients. Eur Urol. 2019;75:268–71. + + 10.1016/j.eururo.2018.10.027 + 30482670 + + + + Wu YM, Welk B. Revisiting current treatment options for stress urinary incontinence and pelvic organ prolapse: a contemporary literature review. Res Rep Urol. 2019;11:179–88. + + 31355157 + + + + Bø K. Pelvic floor muscle training in treatment of female stress urinary incontinence, pelvic organ prolapse and sexual dysfunction. World J Urol. 2012;30:437–43. + + 10.1007/s00345-011-0779-8 + 21984473 + + + + Bø K, Anglès-Acedo S, Batra A, et al. International urogynecology consultation chapter 3 committee 2; conservative treatment of patient with pelvic organ prolapse: pelvic floor muscle training. Int Urogynecol J. 2022;33:2633–67. + + 10.1007/s00192-022-05324-0 + 35980443 + 9477909 + + + + Columbo JA, Kang R, Trooboff SW, et al. Validating publicly available crosswalks for translating ICD-9 to ICD-10 diagnosis codes for cardiovascular outcomes research. Circ Cardiovasc Qual Outcomes. 2018;11: e004782. + + 10.1161/CIRCOUTCOMES.118.004782 + 30354571 + 6501611 + + + + +
+ + + 36917236 + + 2023 + 03 + 14 + +
+ + 2333-0376 + + 37 + 1 + + 2023 Winter + + + Journal of oral & facial pain and headache + J Oral Facial Pain Headache + + Catastrophizing and Hypervigilance Influence Subjective Sleep Quality in Painful TMD Patients. + + 49-55 + + 10.11607/ofph.3269 + + Aims: To determine sleep quality and associated factors in a group of patients with painful TMDs. Methods: The medical records of 80 patients with arthralgia and/or myofascial pain were reviewed and compared to a healthy control group. Data about sex, age, subjective pain, physical activity, social activity, subjective sleep quality (Pittsburgh Sleep Quality Index [PSQI]), pain vigilance (Pain Vigilance and Awareness Questionnaire [PVAQ]), and pain catastrophizing (Pain Catastrophizing Scale [PCS]) were collected. Relationships between PSQI, age, pain intensity, PVAQ, and PCS in the TMD group were also analyzed. Data from the control group were used to transform the PSQI results into T-scores, which were then used to divide the TMD group into two subgroups: normal and impaired sleep. Results: TMD patients presented a significantly higher (P < .001) PSQI score than the control group. Also, in the TMD group, there was a low to moderate correlation between PSQI and pain intensity and a significant correlation between PVAQ and PCS. The impaired sleep group presented a significantly higher (P < .001) PSQI T-score than the normal sleep group. Univariate analysis showed that subjective pain, social activity, and the PCS total and subscale scores differed significantly between the different PSQI T-score groups. The comparison between TMD pain patients and control subjects showed a significantly higher prevalence of T-score discordance in almost all PSQI components in TMD patients with impaired sleep. Conclusion: Subjective sleep quality in painful TMD patients could be associated with and influenced by psychosocial factors (catastrophizing and hypervigilance), social activity, and pain intensity. + + + + Poluha + Rodrigo Lorenzi + RL + + + Canales + Giancarlo De la Torre + GT + + + Ferreira + Dyna Mara + DM + + + Stuginski-Barbosa + Juliana + J + + + Conti + Paulo César Rodrigues + PCR + + + eng + + Journal Article + +
+ + United States + J Oral Facial Pain Headache + 101624698 + +
+ + + + 2023 + 3 + 14 + 12 + 13 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + ppublish + + 36917236 + 10.11607/ofph.3269 + + +
+ + + 36917260 + + 2023 + 03 + 14 + +
+ + 1432-1084 + + + 2023 + Mar + 14 + + + European radiology + Eur Radiol + + Artificial intelligence in BreastScreen Norway: a retrospective analysis of a cancer-enriched sample including 1254 breast cancer cases. + 10.1007/s00330-023-09461-y + + To compare results of selected performance measures in mammographic screening for an artificial intelligence (AI) system versus independent double reading by radiologists. + In this retrospective study, we analyzed data from 949 screen-detected breast cancers, 305 interval cancers, and 13,646 negative examinations performed in BreastScreen Norway during the period from 2010 to 2018. An AI system scored the examinations from 1 to 10, based on the risk of malignancy. Results from the AI system were compared to screening results after independent double reading. AI score 10 was set as the threshold. The results were stratified by mammographic density. + A total of 92.7% of the screen-detected and 40.0% of the interval cancers had an AI score of 10. Among women with a negative screening outcome, 9.1% had an AI score of 10. For women with the highest breast density, the AI system scored 100% of the screen-detected cancers and 48.6% of the interval cancers with an AI score of 10, which resulted in a sensitivity of 80.9% for women with the highest breast density for the AI system, compared to 62.8% for independent double reading. For women with screen-detected cancers who had prior mammograms available, 41.9% had an AI score of 10 at the prior screening round. + The high proportion of cancers with an AI score of 10 indicates a promising performance of the AI system, particularly for women with dense breasts. Results on prior mammograms with AI score 10 illustrate the potential for earlier detection of breast cancers by using AI in screen-reading. + • The AI system scored 93% of the screen-detected cancers and 40% of the interval cancers with AI score 10. • The AI system scored all screen-detected cancers and almost 50% of interval cancers among women with the highest breast density with AI score 10. • About 40% of the screen-detected cancers had an AI score of 10 on the prior mammograms, indicating a potential for earlier detection by using AI in screen-reading. + © 2023. The Author(s). + + + + Koch + Henrik Wethe + HW + + Department of Radiology, Stavanger University Hospital, Stavanger, Norway. + + + Faculty of Health Sciences, University of Stavanger, Stavanger, Norway. + + + + Larsen + Marthe + M + + Section for Breast Cancer Screening, Cancer Registry of Norway, Oslo, Norway. + + + + Bartsch + Hauke + H + + Department of Radiology, Haukeland University Hospital, Bergen, Norway. + + + + Kurz + Kathinka Dæhli + KD + + Department of Radiology, Stavanger University Hospital, Stavanger, Norway. + + + Department of Electrical Engineering and Computer Science, Faculty of Science and Technology, The University of Stavanger, Stavanger, Norway. + + + + Hofvind + Solveig + S + http://orcid.org/0000-0003-0178-8939 + + Section for Breast Cancer Screening, Cancer Registry of Norway, Oslo, Norway. sshh@kreftregisteret.no. + + + Department of Health and Care Sciences, Faculty of Health Sciences, The Arctic University of Norway, Tromsø, Norway. sshh@kreftregisteret.no. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Eur Radiol + 9114774 + 0938-7994 + + IM + + Artificial intelligence + Breast neoplasm + Mammographic density + Mammography + Mass screening + +
+ + + + 2022 + 05 + 25 + + + 2023 + 01 + 24 + + + 2022 + 12 + 13 + + + 2023 + 3 + 14 + 12 + 15 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917260 + 10.1007/s00330-023-09461-y + 10.1007/s00330-023-09461-y + + + + Sung H, Ferlay J, Siegel RL et al (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71:209–249 + + 10.3322/caac.21660 + 33538338 + + + + Marmot MG, Altman DG, Cameron DA, Dewar JA, Thompson SG, Wilcox M (2013) The benefits and harms of breast cancer screening: an independent review. Br J Cancer 108:2205–2240 + + 10.1038/bjc.2013.177 + 23744281 + 3693450 + + + + Lauby-Secretan B, Scoccianti C, Loomis D et al (2015) Breast-cancer screening–viewpoint of the IARC Working Group. N Engl J Med 372:2353–2358 + + 10.1056/NEJMsr1504363 + 26039523 + + + + Stout NK, Lee SJ, Schechter CB et al (2014) Benefits, harms, and costs for breast cancer screening after US implementation of digital mammography. J Natl Cancer Inst 106:dju092 + + + Domingo L, Hofvind S, Hubbard RA et al (2016) Cross-national comparison of screening mammography accuracy measures in U.S., Norway, and Spain. Eur Radiol 26:2520–2528 + + 10.1007/s00330-015-4074-8 + 26560729 + + + + Phi XA, Tagliafico A, Houssami N, Greuter MJW, de Bock GH (2018) Digital breast tomosynthesis for breast cancer screening and diagnosis in women with dense breasts - a systematic review and meta-analysis. BMC Cancer 18:380 + + 10.1186/s12885-018-4263-3 + 29615072 + 5883365 + + + + Mann RM, Athanasiou A, Baltzer PAT et al (2022) Breast cancer screening in women with extremely dense breasts recommendations of the European Society of Breast Imaging (EUSOBI). Eur Radiol. https://doi.org/10.1007/s00330-022-08617-6 + + 10.1007/s00330-022-08617-6 + 35507050 + 9064723 + + + + Meshkat B, Prichard RS, Al-Hilli Z et al (2015) A comparison of clinical-pathological characteristics between symptomatic and interval breast cancer. Breast 24:278–282 + + 10.1016/j.breast.2015.02.032 + 25771080 + + + + Houssami N, Hunter K (2017) The epidemiology, radiology and biological characteristics of interval breast cancers in population mammography screening. NPJ Breast Cancer 3:12 + + 10.1038/s41523-017-0014-x + 28649652 + 5460204 + + + + Hovda T, Hoff SR, Larsen M, Romundstad L, Sahlberg KK, Hofvind S (2021) True and missed interval cancer in organized mammographic screening: a retrospective review study of diagnostic and prior screening mammograms. Acad Radiol. https://doi.org/10.1016/j.acra.2021.03.022 + + 10.1016/j.acra.2021.03.022 + 33926794 + + + + Hoff SR, Samset JH, Abrahamsen AL, Vigeland E, Klepp O, Hofvind S (2011) Missed and true interval and screen-detected breast cancers in a population based screening program. Acad Radiol 18:454–460 + + 10.1016/j.acra.2010.11.014 + 21216632 + + + + Lang K, Hofvind S, Rodriguez-Ruiz A, Andersson I (2021) Can artificial intelligence reduce the interval cancer rate in mammography screening? Eur Radiol. https://doi.org/10.1007/s00330-021-07686-3 + + 10.1007/s00330-021-07686-3 + 34255157 + 8594282 + + + + Larsen M, Aglen CF, Lee CI et al (2022) Artificial intelligence evaluation of 122 969 mammography examinations from a population-based screening program. Radiology. https://doi.org/10.1148/radiol.212381:212381 + + 10.1148/radiol.212381:212381 + 35348377 + + + + Lauritzen AD, Rodriguez-Ruiz A, von Euler-Chelpin MC et al (2022) An artificial intelligence-based mammography screening protocol for breast cancer: outcome and radiologist workload. Radiology. https://doi.org/10.1148/radiol.210948:210948 + + 10.1148/radiol.210948:210948 + 35438561 + + + + Hofvind S, Tsuruda K, Mangerud G, Ertzaas AK (2017) The Norwegian Breast Cancer Screening Program, 1996–2016: celebrating 20 years of organized mammographic screening. Oslo: Cancer Registry of Norway. Available via https://www.kreftregisteret.no/globalassets/cancer-in-norway/2016/mammo_cin2016_special_issue_web.pdf . Accessed 20 May 2022 + + + Raya-Povedano JL, Romero-Martin S, Elias-Cabot E, Gubern-Merida A, Rodriguez-Ruiz A, Alvarez-Benito M (2021) AI-based strategies to reduce workload in breast cancer screening with mammography and tomosynthesis: a retrospective evaluation. Radiology 300:57–65 + + 10.1148/radiol.2021203555 + 33944627 + + + + Lång K, Dustler M, Dahlblom V, Åkesson A, Andersson I, Zackrisson S (2021) Identifying normal mammograms in a large screening population using artificial intelligence. Eur Radiol 31:1687–1692 + + 10.1007/s00330-020-07165-1 + 32876835 + + + + Yala A, Schuster T, Miles R, Barzilay R, Lehman C (2019) A deep learning model to triage screening mammograms: a simulation study. Radiology 293:38–46 + + 10.1148/radiol.2019182908 + 31385754 + + + + Rodriguez-Ruiz A, Lang K, Gubern-Merida A et al (2019) Can we reduce the workload of mammographic screening by automatic identification of normal exams with artificial intelligence? A feasibility study. Eur Radiol 29:4825–4832 + + 10.1007/s00330-019-06186-9 + 30993432 + 6682851 + + + + Kyono T, Gilbert FJ, van der Schaar M (2020) Improving workflow efficiency for mammography using machine learning. J Am Coll Radiol 17:56–63 + + 10.1016/j.jacr.2019.05.012 + 31153798 + + + + Dembrower K, Wahlin E, Liu Y et al (2020) Effect of artificial intelligence-based triaging of breast cancer screening mammograms on cancer detection and radiologist workload: a retrospective simulation study. Lancet Digit Health 2:e468–e474 + + 10.1016/S2589-7500(20)30185-0 + 33328114 + + + + Balta C, Rodriguez-Ruiz A, Mieskes C, Karssemeijer N, Heywang-Köbrunner S (2020) Going from double to single reading for screening exams labeled as likely normal by AI: what is the impact? (Conference Proceedings Article), 15th International Workshop on Breast Imaging (IWBI2020). SPIE, Leuven, Belgium, pp 94–101 + + + Fong Y, Evans J, Brook D, Kenkre J, Jarvis P, Gower-Thomas K (2015) The Nottingham prognostic index: five- and ten-year data for all-cause survival within a screened population. Ann R Coll Surg Engl 97:137–139 + + 10.1308/003588414X14055925060514 + 25723691 + 4473391 + + + + Aitken Z, McCormack VA, Highnam RP et al (2010) Screen-film mammographic density and breast cancer risk: a comparison of the volumetric standard mammogram form and the interactive threshold measurement methods. Cancer Epidemiol Biomarkers Prev 19:418–428 + + 10.1158/1055-9965.EPI-09-1059 + 20142240 + 2875111 + + + + Sickles E, D’Orsi CJ, Bassett LW ACR BI-RADS Mammography. In: ACR BI-RADS Atlas, Breast Imaging Reporting and Data system Reston, Va: American College of Radiology, 2013 + + + Freeman K, Geppert J, Stinton C et al (2021) Use of artificial intelligence for image analysis in breast cancer screening programmes: systematic review of test accuracy. BMJ 374:n1872 + + 10.1136/bmj.n1872 + 34470740 + 8409323 + + + + Haybittle JL, Blamey RW, Elston CW et al (1982) A prognostic index in primary breast cancer. Br J Cancer 45:361–366 + + 10.1038/bjc.1982.62 + 7073932 + 2010939 + + + + Blamey RW, Hornmark-Stenstam B, Ball G et al (2010) ONCOPOOL - a European database for 16,944 cases of breast cancer. Eur J Cancer 46:56–71 + + 10.1016/j.ejca.2009.09.009 + 19811907 + + + + Lundin J, Lehtimaki T, Lundin M et al (2006) Generalisability of survival estimates for patients with breast cancer–a comparison across two population-based series. Eur J Cancer 42:3228–3235 + + 10.1016/j.ejca.2006.06.028 + 17015014 + + + + Boyd NF, Guo H, Martin LJ et al (2007) Mammographic density and the risk and detection of breast cancer. N Engl J Med 356:227–236 + + 10.1056/NEJMoa062790 + 17229950 + + + + McCormack VA, dos Santos SI (2006) Breast density and parenchymal patterns as markers of breast cancer risk: a meta-analysis. Cancer Epidemiol Biomarkers Prev 15:1159–1169 + + 10.1158/1055-9965.EPI-06-0034 + 16775176 + + + + Hofvind S, Geller BM, Rosenberg RD, Skaane P (2009) Screening-detected breast cancers: discordant independent double reading in a population-based screening program. Radiology 253:652–660 + + 10.1148/radiol.2533090210 + 19789229 + + + + Larsen IK, Smastuen M, Johannesen TB et al (2009) Data quality at the Cancer Registry of Norway: an overview of comparability, completeness, validity and timeliness. Eur J Cancer 45:1218–1231 + + 10.1016/j.ejca.2008.10.037 + 19091545 + + + + +
+ + + 36917252 + + 2023 + 03 + 14 + +
+ + 1434-4726 + + + 2023 + Mar + 14 + + + European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery + Eur Arch Otorhinolaryngol + + Use of bonalive in obliterative mastoidectomy: anatomical results and clinical outcome. + 10.1007/s00405-023-07850-z + + To investigate safety and efficacy of mastoid obliteration in canal-wall-down tympanoplasty performed for cholesteatoma using bioactive glass (BAG). The authors routinely adopt CWD tympanoplasty in case of massive cholesteatoma or revision surgery, performing obliteration with BAG to reduce the mastoid cavity and related disadvantages. We assessed anatomical results, infection control and cholesteatoma recurrence in obliterative mastoidectomy using BAG. + The authors evaluated 66 patients treated with obliterative mastoidectomy using BAG during the period 2010-2021. 48.5% of the cases had first diagnosis of cholesteatoma, 48.5% had cholesteatoma recidivisms, and two patients underwent obliteration to improve clinical outcome. BAG granules were always moistened with venous blood to enhance their adhesion and reduce the risk of dispersion. Anatomical results were evaluated in otomicroscopy and infection control was assessed during follow-up visits. Periodical otomicroscopy was performed to check recurrent cholesteatoma. MRI-DWI was indicated only in case of clinical suspect of cholesteatoma. + Authors followed 66 patients during a mean of 23 months. No post-operative wound infections occured. The mean re-epithelialization time was 45 days. At the last visit, control of infection was achieved in 97% of patients and a clinical stable anatomical cavity in all patients. No clinical suspect for recurrent cholesteatoma was found. + The use of bioactive glass is safe and effective as obliteration material in cholesteatoma surgery. Authors pay a particular attention to obliterate only patients without suspect of epithelial residual, to correctly calibrate the ear canal and to completely cover the granules with graft. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Fassone + Elisabetta + E + http://orcid.org/0000-0002-0081-5037 + + Division of Otorhinolaryngology, Department of Surgical Sciences, A. O. Ordine Mauriziano di Torino, Largo Turati 62, 10128, Turin, Italy. elisabetta.fassone@virgilio.it. + + + + Fabiano + Beatrice + B + + Division of Otorhinolaryngology, Department of Surgical Sciences, A. O. Ordine Mauriziano di Torino, Largo Turati 62, 10128, Turin, Italy. + + + + Caracciolo + Alessandra + A + + Division of Otorhinolaryngology, Department of Surgical Sciences, A. O. Ordine Mauriziano di Torino, Largo Turati 62, 10128, Turin, Italy. + + + + Sapino + Silvia + S + + Division of Otorhinolaryngology, Department of Surgical Sciences, A. O. Ordine Mauriziano di Torino, Largo Turati 62, 10128, Turin, Italy. + + + + Ferrero + Vittorio + V + + Division of Otorhinolaryngology, Department of Surgical Sciences, A. O. Ordine Mauriziano di Torino, Largo Turati 62, 10128, Turin, Italy. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Eur Arch Otorhinolaryngol + 9002937 + 0937-4477 + + IM + + Bioactive glass + Canal-wall-down tympanoplasty + Cholesteatoma + Mastoid obliteration + +
+ + + + 2022 + 08 + 22 + + + 2023 + 01 + 11 + + + 2023 + 3 + 14 + 12 + 14 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917252 + 10.1007/s00405-023-07850-z + 10.1007/s00405-023-07850-z + + + + Stoor P, Pulkkinen J, Grenman R (2010) Bioactive glass S53P4 in the filling of cavities in the mastoid cell area in surgery for chronic otitis media. Ann Otol Rhinol Laryngol 119(6):377–382 + + 10.1177/000348941011900603 + 20583735 + + + + Skoulakis C, Koltsidopoulos P, Iyer A, Kontorinis G (2019) Mastoid obliteration with synthetic materials: a review of the literature. J Int Adv Otol 15(3):400–404 + + 10.5152/iao.2019.7038 + 31846919 + 6937173 + + + + Shohet JA, de Jong AL (2002) The management of pediatric cholesteatoma. Otolaryngol Clin N Am 35:841–851 + + 10.1016/S0030-6665(02)00052-X + + + + Sorour SS, Mohamed NN, Abdel Fattah MM, Elbary MEA, El-Anwar MW (2018) Bioglass reconstruction of posterior meatal wall after canal wall down mastoidectomy. Am J Otolaryngol 39:282–285 + + 10.1016/j.amjoto.2018.03.007 + 29526381 + + + + Alves RD, Cabral Junior F, Fonseca AC, Benito RF (2016) Mastoid obliteration with autologous bone in mastoidectomy canal wall down surgery: a literature overview. Int Arch Otorhinolaryngol 20:76–83 + + 10.1055/s-0035-1563382 + 26722350 + + + + Vos PJ, de Vey Mestdagh P, Colnot D, Borggreven P, Orelio C, Quak J (2017) Bioactive glass obliteration of the mastoid significantly improves surgical outcome in non-cholesteatomatous chronic otitis media. Eur Arch Otorhinolaryngol 274(12):4121–4126 + + 10.1007/s00405-017-4757-7 + 28956143 + + + + Castle JT (2018) Cholesteatoma pearls: practical points and update. Head Neck Pathol 12(3):419–429 + + 10.1007/s12105-018-0915-5 + 30069838 + 6081285 + + + + Kuo CL, Shiao AS, Yung M, et al (2015) Updates and knowledge gaps in cholesteatoma research. Biomed Res Int 2015:1–17 + + + Kerckhoffs KGP, Kommer MBJ, van Strien THL, Visscher SJA, Bruijnzeel H, Smit AL, Grolman W (2015) The disease recurrence rate after the canal wall up or canal wall down technique in adults, systematic review. Laryngoscope 126:980–987 + + 10.1002/lary.25591 + 26404516 + + + + van der Toom HFE, van der Schroeff MP, Pauw RJ (2018) Single-stage mastoid obliteration in cholesteatoma surgery and recurrent and residual disease rates a systematic review. JAMA Otolaryngol Head Neck Surg 144(5):440–446 + + 10.1001/jamaoto.2017.3401 + 29543959 + + + + Kuo CL, Liao WH, Shiao AS (2015) A review of current progress in acquired cholesteatoma management. Eur Arch Otorhinolaryngol 272:3601–3609 + + 10.1007/s00405-014-3291-0 + 25227761 + + + + Mendlovic ML, Llaguno DAM, Capetillo IHS, Lesser JCC (2021) Mastoid obliteration and reconstruction techniques: a review of the literature. J Otol 16:178–184 + + 10.1016/j.joto.2021.01.002 + 34220986 + 8241697 + + + + Tomlin J, Chang D, McCutcheon B et al (2013) Surgical technique and recurrence in cholesteatoma: a meta-analysis. Audiol Neurootol 18:135–142 + + 10.1159/000346140 + 23327931 + + + + Vercruysse JP, De Foer B, Somers T, Casselman JW, Offeicers E (2008) Mastoid and epitympanic obliteration in pediatric cholesteatoma. Otol Neurotol 29(7):953–960 + + 10.1097/MAO.0b013e318184f4d6 + 18719515 + + + + Schimanski G, Schimanski E (2016) Mastoid cavity obliteration with bioactive glass granules. In: Recent advances in otolaryngology head & neck surgery, vol 2016. JP Medical Ltd, New York, pp 249–281 + + + Mahendran S, Yung MW (2004) Mastoid obliteration with hydroxyapatite cement: the Ipswich experience. Otol Neurotol. 25:19–21 + + 10.1097/00129492-200401000-00004 + 14724486 + + + + Park JS, Kang MY, Hong JC, Park BG, Kang MK (2011) Result of mastoid obliteration according to the graft materials: autogenous bone, allogeneic bone, hydroxylapatite. J Int Adv Otol 7:305–310 + + + Cho SW, Cho YB, Cho HH (2012) Mastoid obliteration with silicone blocks after canal wall down mastoidectomy. Clin Exp Otorhinolaryngol 5:23–27 + + 10.3342/ceo.2012.5.1.23 + 22468198 + 3314801 + + + + BaonAlive Biomaterials Ltd: instruction for use https://www.bonalive.com/it/products/bonalive-granules/ + + + Stoor P, Pulkkinen J, Grénman R (2010) Bioactive glass S53P4 in the filling of cavities in the mastoid cell area in surgery for chronic otitis media. Ann Otol Rhinol Laryngol 119(6):377–382 + + 10.1177/000348941011900603 + 20583735 + + + + Drago LID, Toscano M, Bottagisio M (2018) Recent evidence on bioactive glass antimicrobial and antibiofilm activity: a mini-review. Materials (Basel) 11(2):326 + + 10.3390/ma11020326 + 29495292 + + + + Bernardeschi D, Pyatigorskaya N, Russo FY, de Seta D, Corallo G, Ferrary E, Nguyen Y, Sterkers O (2017) Anatomical, functional, and quality-of-life results for mastoid and epitympanic obliteration with bioactive glass S53P4: a prospective clinical study. Clin Otolaryngol 42(2):387–396 + + 10.1111/coa.12748 + 27608143 + + + + Aurégan JC, Bégué T (2015) Bioactive glass for long bone infection: A systematic review. Injury 46:S3–S7 + + 10.1016/S0020-1383(15)30048-6 + 26747915 + + + + Van Gestel NA, Geurts J, Hulsen DJ, van Rietbergen B, Hofmann S (2015) Clinical applications of s53p4 bioactive glass in bone healing and osteomyelitic treatment: a literature review. Arts J J Biomed Res Int, pp 1–12 + + + Bernardeschi D, Law-ye B, Bielle F, Hochet B, Sterkers O, Dormont D, Pyatigorskaya N (2019) Bioactive glass granules for mastoid and epitympanic surgical obliteration: CT and MRI appearance. Eur Radiol 29:5617–5626 + + 10.1007/s00330-019-06120-z + 30888487 + + + + Lindfors NC, Hyvönen P, Nyyssönen M et al (2010) Bioactive glass S53P4 as bone graft substitute in treatment of osteomyelitis. Bone 47(2):212–218 + + 10.1016/j.bone.2010.05.030 + 20624692 + + + + Lindfors NC, Koski I, Heikkilä JT et al (2010) A prospective randomized 14-year follow-up study of Bioactive glass and autogenous one as bone graft substitutes in benign bone tumors. Mater Res B Appl Biomater 94:157–164 (J Biomed) + + + Peltola M, Aitasalo K, Suonpää J et al (2006) Bioactive glass S53P4 in frontal sinus obliteration: a long-term clinical experience. Head Neck 28:834–841 + + 10.1002/hed.20436 + 16823870 + + + + +
+ + + 36917257 + + 2023 + 03 + 14 + +
+ + 1433-3023 + + + 2023 + Mar + 14 + + + International urogynecology journal + Int Urogynecol J + + A randomised interventional parallel study to evaluate the effect of different frequencies of pelvic floor muscle exercises with core stabilisation using three-dimensional ultrasound: the PELSTAB study. + 10.1007/s00192-023-05473-w + + The primary objective was to compare high- and low-frequency pelvic floor muscle training (PFMT) with the impact on urinary incontinence episode frequency over 1 week (IEF/week). The secondary objective was to compare the two groups with regard to pelvic floor muscle function, morphometry, incontinence quality of life, and patient global impression. + This was a randomised parallel controlled study. The setting was regional gynaecological and urological outpatient clinics. The subjects consisted of a sample of 86 women with stress urinary incontinence (SUI). Group A underwent high-frequency PFMT and group B underwent low-frequency PFMT for 12 weeks. We recorded the IEF/week. The International Consultation on Incontinence Questionnaire Urinary Incontinence Short Form (ICIQ-UI SF) was used. Pelvic floor muscle function was evaluated using a perineometer. Pelvic floor muscle morphometry was evaluated with 3D/4D ultrasound. The Urinary Incontinence Quality of Life Scale (I-QoL) was used. + Significant differences between group A and B after treatment (p<0.001) were noted in favour of group A in IEF/week (group A 10.2±7.0/2.3±3.0 vs group B 9.3±4.7/6.3±4.9), in the ICIQ-UI SF (group A 9.7±3.0/3.7 ± 3.6 vs group B 9.9±3.2/9.4±3.4). Significant differences between groups A and B after treatment were noted in favour of group A for pelvic floor muscle function in terms of maximal voluntary contraction and its duration, and also for pelvic floor muscle morphometry in terms of a reduction of the hiatal area during rest, contraction, and the Valsalva manoeuvre. + High-frequency PFMT for 12 weeks significantly decreased IEF/week in comparison with low-frequency PFMT. In the high-frequency exercise group, women had significantly better pelvic floor muscle function, morphometry and quality of life than the low-frequency exercise group. + © 2023. The International Urogynecological Association. + + + + Hagovská + Magdaléna + M + + Department of Physiatry, Balneology, and Medical Rehabilitation, Institution - Faculty of Medicine, PJ Safarik University, Kosice, Slovakia. + + + Urogynecology and Physiotherapy in gynecology and urology, Institution - Clinic Centrum s.r.o., Kosice, Slovakia. + + + + Švihra + Ján + J + + Department of Urology, Institution - Jessenius Faculty of Medicine, Martin, Comenius University Bratislava, Bratislava, Slovakia. jan.svihra@uniba.sk. + + + + Urdzík + Peter + P + + Urogynecology and Physiotherapy in gynecology and urology, Institution - Clinic Centrum s.r.o., Kosice, Slovakia. + + + Department of Gynecology and Obstetrics, Institution - Faculty of Medicine, PJ Safarik University, Kosice, Slovakia. + + + + Vaská + Eva + E + + Institute of Physiotherapy, Balneology and Medical Rehabilitation, Faculty of Health Sciences, University of Ss. Cyril and Methodius in Trnava, Trnava, Slovakia. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + England + Int Urogynecol J + 101567041 + 0937-3462 + + IM + + High and low frequency + Life quality + Morphometry + Pelvic floor exercises + Pelvic floor muscle function + +
+ + + + 2022 + 12 + 09 + + + 2023 + 01 + 08 + + + 2023 + 3 + 14 + 12 + 14 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917257 + 10.1007/s00192-023-05473-w + 10.1007/s00192-023-05473-w + + + References + + Abrams P, Andersson KE, Apostolidis A, et al. 6th International Consultation on Incontinence. Recommendations of the International Scientific Committee: evaluation and treatment of urinary incontinence, pelvic organ prolapse and faecal incontinence. Neurourol Urodyn. 2018;37(7):2271–2. + + 10.1002/nau.23551 + 30106223 + + + + Bo K, Frawley HC, Haylen BT, Abramov Y, Almeida FG, Berghmans B, et al. An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint report on the terminology for the conservative and nonpharmacological management of female pelvic floor dysfunction. Neurourol Urodyn. 2017;36(2):221–44. + + 10.1002/nau.23107 + 27918122 + + + + Bo K, Berghmans B, Morkved S, Van Kampen M. Evidence–based physical therapy for the pelvic floor, 2nd Edition. London: Churchill Livingstone, 2015. p. 446. + + + Haylen BT, de Ridder D, Freeman RM, et al. An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint report on the terminology for female pelvic floor dysfunction. Int Urogynecol J. 2010;21(1):5–26. + + 10.1007/s00192-009-0976-9 + 19937315 + + + + Kim EY, Kim SY, Oh DW. Pelvic floor muscle exercises utilizing trunk stabilization for treating postpartum urinary incontinence: randomized controlled pilot trial of supervised versus unsupervised training. Clin Rehabil. 2012;26(2):132–41. + + 10.1177/0269215511411498 + 21849373 + + + + Szumilewicz A, Dornowski M, Piernicka M, et al. High-low impact exercise program including pelvic floor muscle exercises improves pelvic floor muscle function in healthy pregnant women—a randomized control trial. 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+ + + 36917254 + + 2023 + 03 + 14 + +
+ + 1439-6327 + + + 2023 + Mar + 14 + + + European journal of applied physiology + Eur J Appl Physiol + + Distinguishing science from pseudoscience in commercial respiratory interventions: an evidence-based guide for health and exercise professionals. + 10.1007/s00421-023-05166-8 + + Respiratory function has become a global health priority. Not only is chronic respiratory disease a leading cause of worldwide morbidity and mortality, but the COVID-19 pandemic has heightened attention on respiratory health and the means of enhancing it. Subsequently, and inevitably, the respiratory system has become a target of the multi-trillion-dollar health and wellness industry. Numerous commercial, respiratory-related interventions are now coupled to therapeutic and/or ergogenic claims that vary in their plausibility: from the reasonable to the absurd. Moreover, legitimate and illegitimate claims are often conflated in a wellness space that lacks regulation. The abundance of interventions, the range of potential therapeutic targets in the respiratory system, and the wealth of research that varies in quality, all confound the ability for health and exercise professionals to make informed risk-to-benefit assessments with their patients and clients. This review focuses on numerous commercial interventions that purport to improve respiratory health, including nasal dilators, nasal breathing, and systematized breathing interventions (such as pursed-lips breathing), respiratory muscle training, canned oxygen, nutritional supplements, and inhaled L-menthol. For each intervention we describe the premise, examine the plausibility, and systematically contrast commercial claims against the published literature. The overarching aim is to assist health and exercise professionals to distinguish science from pseudoscience and make pragmatic and safe risk-to-benefit decisions. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Illidi + Camilla R + CR + + Clinical Exercise and Respiratory Physiology Laboratory, Department of Kinesiology and Physical Education, Faculty of Education, McGill University, Montréal, QC, Canada. + + + + Romer + Lee M + LM + + Division of Sport, Health and Exercise Sciences, College of Health, Medicine and Life Sciences, Brunel University London, Uxbridge, UK. + + + + Johnson + Michael A + MA + + Exercise and Health Research Group, Sport, Health and Performance Enhancement (SHAPE) Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham, Nottinghamshire, UK. + + + + Williams + Neil C + NC + + Exercise and Health Research Group, Sport, Health and Performance Enhancement (SHAPE) Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham, Nottinghamshire, UK. + + + + Rossiter + Harry B + HB + + Institute of Respiratory Medicine and Exercise Physiology, Division of Respiratory and Critical Care Physiology and Medicine, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, 1124 W. Carson Street, CDCRC Building, Torrance, CA, 90502, USA. + + + + Casaburi + Richard + R + + Institute of Respiratory Medicine and Exercise Physiology, Division of Respiratory and Critical Care Physiology and Medicine, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, 1124 W. Carson Street, CDCRC Building, Torrance, CA, 90502, USA. + + + + Tiller + Nicholas B + NB + http://orcid.org/0000-0001-8429-658X + + Institute of Respiratory Medicine and Exercise Physiology, Division of Respiratory and Critical Care Physiology and Medicine, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, 1124 W. Carson Street, CDCRC Building, Torrance, CA, 90502, USA. nicholas.tiller@lundquist.org. + + + + eng + + Journal Article + Review + + + 2023 + 03 + 14 + +
+ + Germany + Eur J Appl Physiol + 100954790 + 1439-6319 + + IM + + Asthma + COPD + Disease + Exercise + Lung function + Nutrition + Pulmonary + +
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Clin Nutr 33:581–587. https://doi.org/10.1016/J.CLNU.2013.10.002 + + 10.1016/J.CLNU.2013.10.002 + 24268677 + + + + Williams NC, Johnson MA, Shaw DE et al (2016) A prebiotic galactooligosaccharide mixture reduces severity of hyperpnoea-induced bronchoconstriction and markers of airway inflammation. Br J Nutr 116:798–804. https://doi.org/10.1017/S0007114516002762 + + 10.1017/S0007114516002762 + 27523186 + + + + Williams NC, Hunter KA, Shaw DE et al (2017) Comparable reductions in hyperpnoea-induced bronchoconstriction and markers of airway inflammation after supplementation with 6·2 and 3·1 g/d of long-chain n-3 PUFA in adults with asthma. Br J Nutr 117:1379–1389. https://doi.org/10.1017/S0007114517001246 + + 10.1017/S0007114517001246 + 28606216 + + + + Witt JD, Guenette JA, Rupert JL et al (2007) Inspiratory muscle training attenuates the human respiratory muscle metaboreflex. J Physiol 584:1019–1028. https://doi.org/10.1113/jphysiol.2007.140855 + + 10.1113/jphysiol.2007.140855 + 17855758 + 2277000 + + + + Woods A, Gustafson O, Williams M, Stiger R (2022) The effects of inspiratory muscle training on inspiratory muscle strength, lung function and quality of life in adults with spinal cord injuries: a systematic review and meta-analysis. Disabil Rehabil. https://doi.org/10.1080/09638288.2022.2107085 + + 10.1080/09638288.2022.2107085 + 35931101 + + + + World Health Organization (2022) Chronic obstructive pulmonary disease (COPD) [fact sheet]. https://www.who.int/news-room/fact-sheets/detail/chronic-obstructive-pulmonary-disease-(copd ). Accessed 26 Sep 2022 + + + Worraphan S, Thammata A, Chittawatanarat K et al (2020) Effects of inspiratory muscle training and early mobilization on weaning of mechanical ventilation: a systematic review and network meta-analysis. Arch Phys Med Rehabil 101:2002–2014. https://doi.org/10.1016/J.APMR.2020.07.004 + + 10.1016/J.APMR.2020.07.004 + 32750371 + + + + Yagihara F, Lorenzi-Filho G, Santos-Silva R (2017) Nasal dilator strip is an effective placebo intervention for severe obstructive sleep apnea. J Clin Sleep Med 13:215–221. https://doi.org/10.5664/jcsm.6450 + + 10.5664/jcsm.6450 + 27707442 + 5263077 + + + + Yang H, Xun P, He K (2013) Fish and fish oil intake in relation to risk of asthma: a systematic review and meta-analysis. PLoS One 8:e80048. https://doi.org/10.1371/JOURNAL.PONE.0080048 + + 10.1371/JOURNAL.PONE.0080048 + 24265794 + 3827145 + + + + Yang Y, Wei L, Wang S et al (2022) The effects of pursed lip breathing combined with diaphragmatic breathing on pulmonary function and exercise capacity in patients with COPD: a systematic review and meta-analysis. Physiother Theory Pract 38:847–857. https://doi.org/10.1080/09593985.2020.1805834 + + 10.1080/09593985.2020.1805834 + 32808571 + + + + Yepes-Nuñez JJ, Brozek JL, Fiocchi A et al (2018) Vitamin D supplementation in primary allergy prevention: systematic review of randomized and non-randomized studies. Allergy 73:37–49. https://doi.org/10.1111/all.13241 + + 10.1111/all.13241 + 28675776 + + + + Yu H, Su X, Lei T et al (2021) Effect of omega-3 fatty acids on chronic obstructive pulmonary disease: a systematic review and meta-analysis of randomized controlled trials. Int J Chron Obstruct Pulmon Dis 16:2677–2686. https://doi.org/10.2147/COPD.S331154 + + 10.2147/COPD.S331154 + 34588776 + 8476109 + + + + Zaccaro A, Piarulli A, Laurino M et al (2018) How breath-control can change your life: a systematic review on psycho-physiological correlates of slow breathing. Front Hum Neurosci 12:1–16. https://doi.org/10.3389/fnhum.2018.00353 + + 10.3389/fnhum.2018.00353 + + + + Zaki S, Moiz JA, Mujaddadi A et al (2022) Does inspiratory muscle training provide additional benefits during pulmonary rehabilitation in people with interstitial lung disease? A randomized control trial. Physiother Theory Pract 13:24–26. https://doi.org/10.1080/09593985.2021.2024311 + + 10.1080/09593985.2021.2024311 + + + + Zemková E (2014) Significantly and practically meaningful differences in balance research: P values and/or effect sizes? Sports Med 44:879–886. https://doi.org/10.1007/s40279-014-0185-7 + + 10.1007/s40279-014-0185-7 + 24760590 + + + + Zhu M, Wang T, Wang C, Ji Y (2016) The association between vitamin D and COPD risk, severity, and exacerbation: an updated systematic review and meta-analysis. Int J Chron Obstruct Pulmon Dis 11:2597–2607. https://doi.org/10.2147/COPD.S101382 + + 10.2147/COPD.S101382 + 27799758 + 5079694 + + + + +
+ + + 36917261 + + 2023 + 03 + 14 + +
+ + 1432-1084 + + + 2023 + Mar + 14 + + + European radiology + Eur Radiol + + CT-guided quadratus femoris injection for ischiofemoral impingement. + 10.1007/s00330-023-09497-0 + + To describe the technique, efficacy, and safety of CT-guided quadratus femoris injection with corticosteroid and local anesthetic for the treatment of ischiofemoral impingement in a series of cases at our institution. + Cases of CT-guided quadratus femoris injections from 2000 to 2021 were identified in the enterprise-wide electronic medical record of our institution. Patient charts and our institutional picture archiving and communication system (PACS) were searched for demographics, pain level on a 0-10 scale before and immediately following the procedure, procedure technique, and follow-up outcomes if available. + There were 13 cases among 12 patients with clinical and imaging findings of ischiofemoral impingement included in this study. Of the 12 patients, 10 were female and two were male. There were eight posterior approaches and five posterolateral approaches. Of the 13 cases, 11 resulted in immediate pain reduction. The median reduction in pain score was four (average 3.46, range 0-8.5). There was no statistically significant difference in pain reduction between the posterior approach cases and the posterolateral approach cases. No cases reported immediate complications or increases in pain score. Of the 12 cases, seven resulted in at least 1 month of pain relief, three had subsequent surgeries, and three had no follow-up. + CT-guided quadratus femoris injection is safe and effective for treating ischiofemoral impingement. Further and larger scale study is needed to fully delineate differences in technique effectiveness. + • CT-guided quadratus femoris injection is safe and effective for treating ischiofemoral impingement. • We found no statistically significant difference in pain reduction between the posterior approach and the posterolateral approach. + © 2023. The Author(s), under exclusive licence to European Society of Radiology. + + + + Liou + Harris + H + + Mayo Clinic Alix School of Medicine, 13400 E. Shea Blvd., Scottsdale, AZ, 85259, USA. + + + + Long + Jeremiah + J + + Mayo Clinic Arizona, 5777 East Mayo Clinic Blvd, Phoenix, AZ, 85054, USA. + + + + Kransdorf + Mark + M + + Mayo Clinic Arizona, 5777 East Mayo Clinic Blvd, Phoenix, AZ, 85054, USA. + + + + Schmieder + Stephanie + S + http://orcid.org/0000-0003-3242-0440 + + Creighton University at St Joseph's Hospital Phoenix, 350 West Thomas Rd, Phoenix, AZ, 85013, USA. stephanie.schmieder901@commonspirit.org. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Eur Radiol + 9114774 + 0938-7994 + + IM + + CT-guided + Ischiofemoral impingement + Quadratus femoris injection + +
+ + + + 2022 + 08 + 15 + + + 2023 + 02 + 03 + + + 2023 + 02 + 02 + + + 2023 + 3 + 14 + 12 + 15 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917261 + 10.1007/s00330-023-09497-0 + 10.1007/s00330-023-09497-0 + + + + Taneja AK, Bredella MA, Torriani M (2013) Ischiofemoral impingement. Magn Reson Imaging Clin N Am 21:65–73. https://doi.org/10.1016/J.MRIC.2012.08.005 + + 10.1016/J.MRIC.2012.08.005 + 23168183 + + + + Patti JW, Ouellette H, Bredella MA, Torriani M (2008) Impingement of lesser trochanter on ischium as a potential cause for hip pain. Skeletal Radiol 37:939–941. https://doi.org/10.1007/S00256-008-0551-3/FIGURES/3 + + 10.1007/S00256-008-0551-3/FIGURES/3 + 18682931 + + + + Hernando MF, Cerezal L, Pérez-Carro L et al (2016) Evaluation and management of ischiofemoral impingement: a pathophysiologic, radiologic, and therapeutic approach to a complex diagnosis. Skeletal Radiol 45:771–787. https://doi.org/10.1007/S00256-016-2354-2/FIGURES/28 + + 10.1007/S00256-016-2354-2/FIGURES/28 + 26940209 + + + + Ali AM, Whitwell D, Ostlere SJ (2011) Case report: imaging and surgical treatment of a snapping hip due to ischiofemoral impingement. Skeletal Radiol 40:653–656. https://doi.org/10.1007/S00256-010-1085-Z/FIGURES/6 + + 10.1007/S00256-010-1085-Z/FIGURES/6 + 21207021 + + + + Park JW, Lee YK, Lee YJ et al (2020) Deep gluteal syndrome as a cause of posterior hip pain and sciatica-like pain. Bone Jt J B102:556–567. https://doi.org/10.1302/0301-620X.102B5.BJJ-2019-1212.R1/ASSET/IMAGES/MEDIUM/BJJ-2019-1212.R1-GALLEYFIG4.GIF + + 10.1302/0301-620X.102B5.BJJ-2019-1212.R1/ASSET/IMAGES/MEDIUM/BJJ-2019-1212.R1-GALLEYFIG4.GIF + + + + Torriani M, Souto SCL, Thomas BJ et al (2012) Ischiofemoral impingement syndrome: an entity with hip pain and abnormalities of the quadratus femoris muscle. AJR Am J Roentgenol 193:186–190. https://doi.org/10.2214/AJR.08.2090 + + + Gómez-Hoyos J, Martin RRL, Schröder R et al (2016) Accuracy of 2 clinical tests for ischiofemoral impingement in patients with posterior hip pain and endoscopically confirmed diagnosis. Arthroscopy 32:1279–1284. https://doi.org/10.1016/J.ARTHRO.2016.01.024 + + + Gómez-Hoyos J, Schröder R, Reddy M et al (2016) Femoral neck anteversion and lesser trochanteric retroversion in patients with ischiofemoral impingement: a case-control magnetic resonance imaging study. Arthroscopy 32:13–18. https://doi.org/10.1016/J.ARTHRO.2015.06.034 + + + Park S, Lee HY, Cuong PM et al (2016) Supine versus standing radiographs for detecting ischiofemoral impingement: a propensity score-matched analysis. AJR Am J Roentgenol 206:1253–1263. https://doi.org/10.2214/AJR.15.15186 + + 10.2214/AJR.15.15186 + 27070951 + + + + Johnson KA (1977) Impingement of the lesser trochanter on the ischial ramus after total hip arthroplasty. Report of three cases. J Bone Joint Surg Am 59:268–269. https://doi.org/10.2106/00004623-197759020-00028 + + 10.2106/00004623-197759020-00028 + 845219 + + + + Wilson MD, Keene JS (2016) Treatment of ischiofemoral impingement: results of diagnostic injections and arthroscopic resection of the lesser trochanter. J Hip Preserv Surg 3:146–153. https://doi.org/10.1093/JHPS/HNW006 + + 10.1093/JHPS/HNW006 + 27583151 + 5005049 + + + + Safran M, Ryu J (2014) Ischiofemoral impingement of the hip: a novel approach to treatment. Knee Surgery Sport Traumatol Arthrosc 22:781–785. https://doi.org/10.1007/S00167-013-2801-8/FIGURES/6 + + 10.1007/S00167-013-2801-8/FIGURES/6 + + + + Gollwitzer H, Banke IJ, Schauwecker J et al (2017) How to address ischiofemoral impingement? Treatment algorithm and review of the literature. J Hip Preserv Surg 4:289–298. https://doi.org/10.1093/JHPS/HNX035 + + 10.1093/JHPS/HNX035 + 29250337 + 5721376 + + + + Nakano N, Shoman H, Khanduja V (2020) Treatment strategies for ischiofemoral impingement: a systematic review. Knee Surg Sport Traumatol Arthrosc 28:2772–2787. https://doi.org/10.1007/S00167-018-5251-5/TABLES/5 + + 10.1007/S00167-018-5251-5/TABLES/5 + + + + Volokhina Y, Dang D (2013) Using proximal hamstring tendons as a landmark for ultrasound- and CT-guided injections of ischiofemoral impingement. Radiol Case Rep 8:789. https://doi.org/10.2484/RCR.V8I1.789 + + 10.2484/RCR.V8I1.789 + 27330616 + + + + Kim DH, Yoon DM, Yoon KB (2016) Ultrasound-guided quadratus femoris muscle injection in patients with lower buttock pain: novel ultrasound-guided approach and clinical effectiveness. Pain Phys 19:E863–E870. https://doi.org/10.36076/PPJ/2016.19.E863 + + + Kim WJ, Shin HY, Koo GH et al (2014) Ultrasound-guided prolotherapy with polydeoxyribonucleotide sodium in ischiofemoral impingement syndrome. Pain Pract 14:649–655. https://doi.org/10.1111/PAPR.12215 + + 10.1111/PAPR.12215 + 24734999 + + + + Makkar JK, Singh PM, Jain D, Goudra B (2016) Particulate vs non-particulate steroids for transforaminal epidural steroid injections: systematic review and meta-analysis of the current literature. Pain Phys 19:327–340. https://doi.org/10.36076/ppj/2016.19.327 + + + Backer MW, Lee KS, Blankenbaker DG, et al (2014) Correlation of ultrasound-guided corticosteroid injection of the quadratus femoris with MRI findings of ischiofemoral impingement. AJR Am J Roentgenol 203:589–593. https://doi.org/10.2214/AJR.13.12304 + + + Bredella MA, Azevedo DC, Oliveira AL et al (2014) Pelvic morphology in ischiofemoral impingement. Skeletal Radiol 44:249–253. https://doi.org/10.1007/S00256-014-2041-0/FIGURES/3 + + 10.1007/S00256-014-2041-0/FIGURES/3 + 25371087 + + + + Tosun Ö, Çay N, Bozkurt M, Arslan H (2012) Ischiofemoral impingement in an 11-year-old girl. Diagn Interv Radiol 18:571–573. https://doi.org/10.4261/1305-3825.DIR.5728-12.1 + + 10.4261/1305-3825.DIR.5728-12.1 + 22684486 + + + + Hayat Z, Konan S, Pollock R (2014) Ischiofemoral impingement resulting from a chronic avulsion injury of the hamstrings. BMJ Case Rep. https://doi.org/10.1136/BCR-2014-204017 + + 10.1136/BCR-2014-204017 + 25312889 + 4195168 + + + + Yanagishita CMA, Falótico GG, Rosário DAV et al (2012) Ischiofemoral impingement: an etiology of hip pain: case report. Rev Bras Ortop 47:780–783. https://doi.org/10.1590/S0102-36162012000600020 + + 10.1590/S0102-36162012000600020 + 27047901 + + + + +
+ + + 36917267 + + 2023 + 03 + 14 + +
+ + 1433-0350 + + + 2023 + Mar + 14 + + + Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery + Childs Nerv Syst + + Clinical presentation, natural history, and outcomes for infantile intracranial cavernous malformations: case series and systematic review of the literature. + 10.1007/s00381-023-05903-6 + + Intracranial cavernous malformations (CMs) are rare vascular malformations of the central nervous system in children. Infantile patients, being a developmentally vulnerable age group, pose a special challenge for management of these lesions. We pooled data from infantile patients diagnosed at our institution and individual cases published in the literature to provide input towards therapeutic decision-making. + A systematic search of PubMed, MEDLINE, Embase, and Scopus was performed in accordance with PRISMA guidelines to identify all reported cases of intracranial CMs in the literature for infantile patients aged ≤ 2 years. In addition, cases from our institution diagnosed between 2010 and 2020 were also included. Individual cases were pooled and analyzed for clinical presentation, natural history, and outcomes from conservative and surgical management. + A total of 36 cases were included, of which 32 were identified from the literature. Median age at presentation was 14 months (range: 2 days to 24 months) months; 53% (n = 19) were females. Most cavernomas (64%, 23/36) were supratentorial, while 30% (n = 11) were located in brainstem and 5.5% (n = 2) in the cerebellum. With the exception of one patient, all cases were reported to be symptomatic; seizures (n = 15/31, 48.3%) and motor deficits (n = 13/31, 42%) were the most common symptom modalities. A total of 13 patients were managed conservatively upon initial presentation. No symptomatic hemorrhages were observed during 26 total person-years of follow-up. A total of 77% (28/36) underwent surgery; either upfront (23/28, 82%) at initial presentation or following conservative management. Among 12 patients who had preoperative seizures, 11/12 (91.6%) achieved seizure freedom post-resection. Among 7 patients who presented with hemiparesis preoperatively, 5 (71%) demonstrated some improvement, while 1 remained unchanged, and another patient with a brainstem cavernous malformation had worsening of motor function postoperatively. Postoperative recurrence was noted in 3 cases (3/27, 11%). + Annual risk of repeat hemorrhage may be low for infantile patients with intracranial cavernous malformations; however, better follow-up rates and higher number of cases are needed to make a definitive assertion. Surgical resection may be associated with high rates of epilepsy cure and provide improvement in neurological function in a select number of cases. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Goyal + Anshit + A + + Department of Neurologic Surgery, Mayo Clinic, Jacksonville, FL, USA. + + + + Fernandes-Torres + Jenelys + J + + City University of New York School of Medicine, New York, NY, USA. + + + Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA. + + + + Flemming + Kelly D + KD + + Department of Neurology, Mayo Clinic, Rochester, MN, USA. + + + + Williams + Lindsy N + LN + + Department of Neurology, Mayo Clinic, Jacksonville, FL, USA. + + + + Daniels + David J + DJ + + City University of New York School of Medicine, New York, NY, USA. daniels.david@mayo.edu. + + + + eng + + Journal Article + Review + + + 2023 + 03 + 14 + +
+ + Germany + Childs Nerv Syst + 8503227 + 0256-7040 + + IM + + Cavernoma + Intracranial hemorrhage + Intraparenchymal hemorrhage + Pediatric + Vascular malformation + +
+ + + + 2023 + 01 + 21 + + + 2023 + 02 + 24 + + + 2023 + 3 + 14 + 12 + 15 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917267 + 10.1007/s00381-023-05903-6 + 10.1007/s00381-023-05903-6 + + + + Fortuna A, Ferrante L, Mastronardi L et al (1989) Cerebral cavernous angioma in children. Childs Nerv Syst 5:201–207 + + 10.1007/BF00271020 + 2676161 + + + + Li D, Hao S-Y, Tang J et al (2014) Surgical management of pediatric brainstem cavernous malformations. J Neurosurg Pediatr 13:484–502 + + 10.3171/2014.2.PEDS13536 + 24679081 + + + + Del Curling O Jr, Kelly DL Jr, Elster AD, Craven TE (1991) An analysis of the natural history of cavernous angiomas. J Neurosurg 75:702–708 + + 10.3171/jns.1991.75.5.0702 + 1919691 + + + + Houtteville JP (1995) The surgery of cavernomas both supra-tentorial and infra-tentorial. Adv Tech Stand Neurosurg 22:185–259 + + 10.1007/978-3-7091-6898-1_4 + 7495419 + + + + Tirakotai W, Fremann S, Soerensen N et al (2006) Biological activity of paediatric cerebral cavernomas: an immunohistochemical study of 28 patients. Childs Nerv Syst 22:685–691 + + 10.1007/s00381-006-0044-4 + 16489474 + + + + Al-Shahi Salman R, Berg MJ, Morrison L et al (2008) Hemorrhage from cavernous malformations of the brain: definition and reporting standards. Angioma Alliance Scientific Advisory Board Stroke 39:3222–3230 + + 18974380 + + + + Gross BA, Smith ER, Scott RM (2013) Cavernous malformations of the basal ganglia in children. J Neurosurg Pediatr 12:171–174 + + 10.3171/2013.5.PEDS1335 + 23790162 + + + + Florian IA, Timis TL, Kiss KR et al (2021) Ruptured pontine cavernomas in infants: a report of two cases. Childs Nerv Syst 37:1009–1015 + + 10.1007/s00381-020-04898-8 + 33070216 + + + + Fanous AA, Jowdy PK, Lipinski LJ et al (2016) Association between trauma and acute hemorrhage of cavernous malformations in children: report of 3 cases. J Neurosurg Pediatr 18:263–268 + + 10.3171/2016.3.PEDS15517 + 27153379 + + + + Velz J, Özkaratufan S, Krayenbühl N et al (2022) Pediatric brainstem cavernous malformations: 2-center experience in 40 children. J Neurosurg Pediatr 1–12 + + + Consales A, Piatelli G, Ravegnani M et al (2010) Treatment and outcome of children with cerebral cavernomas: a survey on 32 patients. Neurol Sci 31:117–123 + + 10.1007/s10072-009-0157-0 + 19834644 + + + + Bigi S, Capone Mori A, Steinlin M et al (2011) Cavernous malformations of the central nervous system in children: presentation, treatment and outcome of 20 cases. Eur J Paediatr Neurol 15:109–116 + + 10.1016/j.ejpn.2010.09.004 + 21041104 + + + + Lee J-W, Kim D-S, Shim K-W et al (2008) Management of intracranial cavernous malformation in pediatric patients. Childs Nerv Syst 24:321–327 + + 10.1007/s00381-007-0465-8 + 17876588 + + + + Villaseñor-Ledezma J, Budke M, Alvarez-Salgado J-A et al (2017) Pediatric cerebellar giant cavernous malformation: case report and review of literature. Childs Nerv Syst 33:2187–2191 + + 10.1007/s00381-017-3550-7 + 28744689 + + + + Jurkiewicz E, Marcinska B, Malczyk K et al (2013) Giant cerebellar cavernous malformation in 4-month-old boy. Case report and review of the literature. Neurol Neurochir Pol 47:596–600 + + 10.5114/ninp.2013.39078 + 24375007 + + + + Di Rocco C, Iannelli A, Tamburrini G (1997) Cavernous angiomas of the brain stem in children. Pediatr Neurosurg 27:92–99 + + 10.1159/000121233 + 9520081 + + + + Amato MCM, Madureira JFG, de Oliveira RS (2013) Intracranial cavernous malformation in children: a single-centered experience with 30 consecutive cases. Arq Neuropsiquiatr 71:220–228 + + 10.1590/0004-282X20130006 + 23588283 + + + + Acciarri N, Galassi E, Giulioni M et al (2009) Cavernous malformations of the central nervous system in the pediatric age group. Pediatr Neurosurg 45:81–104 + + 10.1159/000209283 + 19307743 + + + + Al-Holou WN, O’Lynnger TM, Pandey AS et al (2012) Natural history and imaging prevalence of cavernous malformations in children and young adults. J Neurosurg Pediatr 9:198–205 + + 10.3171/2011.11.PEDS11390 + 22295927 + + + + Gross BA, Du R, Orbach DB et al (2016) The natural history of cerebral cavernous malformations in children. J Neurosurg Pediatr 17:123–128 + + 10.3171/2015.2.PEDS14541 + 26474098 + + + + Abla AA, Lekovic GP, Garrett M et al (2010) Cavernous malformations of the brainstem presenting in childhood: surgical experience in 40 patients. Neurosurgery 67:1589–98; discussion 1598–9 + + + +
+ + + 36917259 + + 2023 + 03 + 14 + +
+ + 1460-2083 + + + 2023 + Mar + 14 + + + Human molecular genetics + Hum Mol Genet + + Genetic modifiers modulate phenotypic expression of tafazzin deficiency in a mouse model of Barth syndrome. + ddad041 + 10.1093/hmg/ddad041 + + Barth syndrome is an X-linked disorder caused by loss-of-function mutations in Tafazzin (TAZ), an acyltransferase that catalyzes remodeling of cardiolipin, a signature phospholipid of the inner mitochondrial membrane. Patients develop cardiac and skeletal muscle weakness, growth delay, and neutropenia, although phenotypic expression varies considerably between patients. Taz knockout mice recapitulate many of the hallmark features of the disease. We used mouse genetics to test the hypothesis that genetic modifiers alter the phenotypic manifestations of Taz inactivation. We crossed TazKO/X females in the C57BL6/J inbred strain to males from 8 inbred strains and evaluated the phenotypes of first generation (F1) TazKO/Y progeny, compared to TazWT/Y littermates. We observed that genetic background strongly impacted phenotypic expression. C57BL6/J and CAST/EiJ[F1] TazKO/Y mice developed severe cardiomyopathy, whereas A/J[F1] TazKO/Y mice had normal heart function. C57BL6/J and WSB/EiJ[F1] TazKO/Y mice had severely reduced treadmill endurance, whereas endurance was normal in A/J[F1] and CAST/EiJ[F1] TazKO/Y mice. In all genetic backgrounds, cardiolipin showed similar abnormalities in knockout mice, and transcriptomic and metabolomic investigations identified signatures of mitochondrial uncoupling and activation of the integrated stress response. TazKO/Y cardiac mitochondria were small, clustered, and had reduced cristae density in knockouts in severely affected genetic backgrounds but were relatively preserved in the permissive A/J[F1] strain. Gene expression and mitophagy measurements were consistent with reduced mitophagy in knockout mice in genetic backgrounds intolerant of Taz mutation. Our data demonstrate that genetic modifiers powerfully modulate phenotypic expression of Taz loss-of-function and act downstream of cardiolipin, possibly by altering mitochondrial quality control. + © The Author(s) 2023. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com. + + + + Wang + Suya + S + + Department of Cardiology, Boston Children's Hospital, Boston, MA, USA. + + + + Yazawa + Erika + E + + Division of Newborn Medicine, Boston Children's Hospital, Boston, MA, USA. + + + + Keating + Erin + E + + Department of Cardiology, Boston Children's Hospital, Boston, MA, USA. + + + + Mazumdar + Neil + N + + Department of Cardiology, Boston Children's Hospital, Boston, MA, USA. + + + + Hauschild + Alexander + A + + Department of Cardiology, Boston Children's Hospital, Boston, MA, USA. + + + + Ma + Qing + Q + + Department of Cardiology, Boston Children's Hospital, Boston, MA, USA. + + + + Wu + Haiyan + H + + Department of Pharmacology, Sichuan University West China School of Basic Sciences and Forensic Medicine, Chengdu, Sichuan, China. + + + + Xu + Yang + Y + + Department of Anesthesiology, New York University School of Medicine, New York, NY, USA. + + + + Shi + Xu + X + + Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA. + + + + Strathdee + Douglas + D + + Transgenic Technology Laboratory, Cancer Research UK Beatson Institute, Glasgow, UK. + + + + Gerszten + Robert E + RE + + Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA. + + + + Schlame + Michael + M + + Department of Anesthesiology, New York University School of Medicine, New York, NY, USA. + + + + Pu + William T + WT + + Department of Cardiology, Boston Children's Hospital, Boston, MA, USA. + + + Transgenic Technology Laboratory, Cancer Research UK Beatson Institute, Glasgow, UK. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + England + Hum Mol Genet + 9208958 + 0964-6906 + + IM +
+ + + + 2023 + 01 + 31 + + + 2023 + 02 + 27 + + + 2023 + 3 + 14 + 12 + 14 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917259 + 7077434 + 10.1093/hmg/ddad041 + + +
+ + + 36917262 + + 2023 + 03 + 14 + +
+ + 1438-7948 + + 23 + 2 + + 2023 + Mar + 14 + + + Functional & integrative genomics + Funct Integr Genomics + + Ensemble learning-based gene signature and risk model for predicting prognosis of triple-negative breast cancer. + + 81 + + 10.1007/s10142-023-01009-z + + Although medical science has been fully developed, due to the high heterogeneity of triple-negative breast cancer (TNBC), it is still difficult to use reasonable and precise treatment. In this study, based on local optimization-feature screening and genomics screening strategy, we screened 25 feature genes. In multiple machine learning algorithms, feature genes have excellent discriminative diagnostic performance among samples composed of multiple large datasets. After screening at the single-cell level, we identified genes expressed substantially in myeloid cells (MCGs) that have a potential association with TNBC. Based on MCGs, we distinguished two types of TNBC patients who showed considerable differences in survival status and immune-related characteristics. Immune-related gene risk scores (IRGRS) were established, and their validity was verified using validation cohorts. A total of 25 feature genes were obtained, among which CXCL9, CXCL10, CCL7, SPHK1, and TREM1 were identified as the result after single-cell level analysis and screening. According to these entries, the cohort was divided into MCA and MCB subtypes, and the two subtypes had significant differences in survival status and tumor-immune microenvironment. After Lasso-Cox screening, IDO1, GNLY, IRF1, CTLA4, and CXCR6 were selected for constructing IRGRS. There were significant differences in drug sensitivity and immunotherapy sensitivity among high-IRGRS and low-IRGRS groups. We revealed the dynamic relationship between TNBC and TIME, identified a potential biomarker called Granulysin (GNLY) related to immunity, and developed a multi-process machine learning package called "MPMLearning 1.0" in Python. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Li + Tiancheng + T + + School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, China. + + + + Chen + Siqi + S + + School of Medical Devices, Shenyang Pharmaceutical University, Shenyang, 110016, China. + + + + Zhang + Yuqi + Y + + School of Medical Devices, Shenyang Pharmaceutical University, Shenyang, 110016, China. + + + + Zhao + Qianqian + Q + + School of Life Sciences and Biopharmaceutical Science, Shenyang Pharmaceutical University, Shenyang, 110016, China. + + + + Ma + Kai + K + + School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, China. + + + + Jiang + Xiwei + X + + School of Medical Devices, Shenyang Pharmaceutical University, Shenyang, 110016, China. + + + + Xiang + Rongwu + R + + School of Medical Devices, Shenyang Pharmaceutical University, Shenyang, 110016, China. + + + Liaoning Medical Big Data and Artificial Intelligence Engineering Technology Research Center, Shenyang, 110016, China. + + + + Zhai + Fei + F + + School of Medical Devices, Shenyang Pharmaceutical University, Shenyang, 110016, China. feirr.zhai@qq.com. + + + + Ling + Guixia + G + + School of Medical Devices, Shenyang Pharmaceutical University, Shenyang, 110016, China. pharlab@163.com. + + + + eng + + + 2020LZD03 + The Key Project supported by the Scientific Research Foundation of the Education Bureau of Liaoning Province + + + + XLYC2005014 + The Liaoning XingLiao Talents Project + + + + U1908215 + National Natural Science Foundation of China + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Funct Integr Genomics + 100939343 + 1438-793X + + IM + + Genomics + Immune + Machine learning + Myeloid cell + Triple-negative breast cancer + +
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+ + + 36917264 + + 2023 + 03 + 14 + +
+ + 1432-0800 + + 110 + 3 + + 2023 + Mar + 14 + + + Bulletin of environmental contamination and toxicology + Bull Environ Contam Toxicol + + Effects of Phenanthrene Exposure on the B-esterases Activities of Octopus maya (Voss and Solís Ramírez, 1996) Embryos. + + 63 + + 10.1007/s00128-023-03706-8 + + No ecotoxicological information exists on phenanthrene (Phe) exposure in cephalopods, animals of commercial and ecological importance. This study investigated the effect of Phe on two B-esterases, Acetylcholinesterase (AChE) and Carboxylesterases (CbE), in Octopus maya embryos. Octopus embryos were exposed to different treatments: control (seawater), solvent control (seawater and DMSO 0.01%), 10 and 100 µg/L of Phe. AChE and CbE activities were measured at different developmental stages (blastula, organogenesis, and growth). B-esterase activities increased in control and solvent control as the embryos developed, showing no statistically significant differences between them. On the other hand, the embryos exposed to Phe had significant differences from controls, and between the high and low concentrations. Our results indicate that B-esterases are sensitive biomarkers of exposure to Phe in O. maya. Still, complementary studies are needed to unravel the toxicodynamics of Phe and the implications of the found inhibitory effect in hatched organisms. + © 2023. The Author(s). + + + + Aguilar + Letícia + L + + Unidad de Química en Sisal, Facultad de Química, Universidad Nacional Autónoma de México, Puerto de Abrigo S/N, Sisal, Yucatán, Mexico. + + + + Moreno-Ortiz + Gissela + G + + Unidad de Química en Sisal, Facultad de Química, Universidad Nacional Autónoma de México, Puerto de Abrigo S/N, Sisal, Yucatán, Mexico. + + + + Caamal-Monsreal + Claudia + C + + Unidad Multidisciplinaria de Docencia e Investigación, Facultad de Ciencias, Universidad Nacional Autónoma de México, Puerto de Abrigo S/N, Sisal, Yucatán, Mexico. + + + + Rosas + Carlos + C + + Unidad Multidisciplinaria de Docencia e Investigación, Facultad de Ciencias, Universidad Nacional Autónoma de México, Puerto de Abrigo S/N, Sisal, Yucatán, Mexico. + + + + Noreña-Barroso + Elsa + E + + Unidad de Química en Sisal, Facultad de Química, Universidad Nacional Autónoma de México, Puerto de Abrigo S/N, Sisal, Yucatán, Mexico. + + + + Gómez-Maldonado + María Concepción + MC + + Unidad de Química en Sisal, Facultad de Química, Universidad Nacional Autónoma de México, Puerto de Abrigo S/N, Sisal, Yucatán, Mexico. + + + + Rodríguez-Fuentes + Gabriela + G + http://orcid.org/0000-0003-4028-0775 + + Unidad de Química en Sisal, Facultad de Química, Universidad Nacional Autónoma de México, Puerto de Abrigo S/N, Sisal, Yucatán, Mexico. grf@unam.mx. + + + Unidad de Química en Sisal, Facultad de Química, UNAM, Av. Colón # 503 F X 62 y Reforma Colonia Centro, 97000, Mérida, Yucatán, Mexico. grf@unam.mx. + + + + eng + + + IN203022 + UNAM-DGAPA-PAPIIT + + + + Postdoctoral Fellowship + UNAM-DGAPA + + + + PAIP + UNAM Facultad de Química + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Bull Environ Contam Toxicol + 0046021 + 0007-4861 + + IM + + B-esterase + Octopus + Phenantrene + +
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+ + 1433-0350 + + + 2023 + Mar + 14 + + + Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery + Childs Nerv Syst + + Failure to fortify staple foods with folic acid-still public health malpractice. + 10.1007/s00381-023-05909-0 + + + Oakley + Godfrey P + GP + Jr + + Department of Epidemiology, Emory University Rollins School of Public Health, 1518 Clifton Rd NE, Atlanta, GA, 30032, USA. gpoakley@mindspring.com. + + + Center for Spina Bifida Prevention, Department of Epidemiology, Emory University Rollins School of Public Health, 1518 Clifton Rd NE, Atlanta, GA, 30032, USA. gpoakley@mindspring.com. + + + + eng + + Journal Article + Review + + + 2023 + 03 + 14 + +
+ + Germany + Childs Nerv Syst + 8503227 + 0256-7040 + + IM + + 2030 Sustainable Development Goals + Anencephaly F + Birth defects prevention + Infant mortality prevention + Preventive medicine + Required folic acid fortification + Spina bifida F + +
+ + + + 2023 + 02 + 07 + + + 2023 + 02 + 27 + + + 2023 + 3 + 14 + 12 + 15 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917266 + 10.1007/s00381-023-05909-0 + 10.1007/s00381-023-05909-0 + + + + Oakley GP Jr (1993) Folic acid-preventable spina bifida and anencephaly. JAMA 269(10):1292–1293 + + 10.1001/jama.1993.03500100090035 + 8437310 + + + + Oakley GP Jr (2002) Inertia on folic acid fortification: public health malpractice. Teratology 66(1):44–54 + + 10.1002/tera.10079 + 12115780 + + + + Medical Research Council (1991) Prevention of neural tube defects results of the Medical Research Council Vitamin Study. MRC Vitamin Study Research Group Lancet 338(8760):131–137 + + + Kancherla V, Redpath B, Oakley GP Jr (2019) Reductions in child mortality by preventing spina bifida and anencephaly: implications in achieving Target 3.2 of the Sustainable Development Goals in developing countries. Birth Defects Res 111(14):958–966 + + + Kancherla V, Wagh K, Pachón H, Oakley GP Jr (2021) A 2019 global update on folic acid-preventable spina bifida and anencephaly. Birth Defects Res 113(1):77–89 + + 10.1002/bdr2.1835 + 33124747 + + + + Christianson A, Howson CP, Modell B (2006) March of Dimes global report on birth defects: the hidden toll of dying and disabled children. White Plains, NY: March of Dimes + + + Blencowe H, Kancherla V, Moorthie S, Darlison MW, Modell B (2018) Estimates of global and regional prevalence of neural tube defects for 2015: a systematic analysis. Ann N Y Acad Sci 1414(1):31–46 + + 10.1111/nyas.13548 + 29363759 + + + + MacMahon B, Yen S (1971) Unrecognised epidemic of anencephaly and spina bifida. Lancet 1(7688):31–33 + + 10.1016/S0140-6736(71)80026-0 + 4099330 + + + + Elwood JH, Nevin NC (1973) Anencephalus and spina bifida in Belfast (1964–1968). Ulster Med J 42(2):213–222 + + 4589090 + 2385418 + + + + Berry RJ, Li Z, Erickson JD, Li S, Moore CA, Wang H, Mulinare J, Zhao P, Wong LY, Gindler J, Hong SX, Correa A (1999) Prevention of neural-tube defects with folic acid in China. China-U.S. Collaborative Project for Neural Tube Defect Prevention. N Engl J Med 341(20):1485–90 + + + Atlaw D, Tekalegn Y, Sahiledengle B, Seyoum K, Solomon D, Gezahegn H, Tariku Z, Tekle Y, Chattu VK (2021) Magnitude and determinants of neural tube defect in Africa: a systematic review and meta-analysis. BMC Pregnancy Childbirth 21(1):426 + + 10.1186/s12884-021-03848-9 + 34126936 + 8204447 + + + + Ethiopian Public Health Institute (2016) Ethiopian National Micronutrient Survey Report, September 2016. Available at: https://www.ephi.gov.et/images/pictures/download2009/National_MNS_report.pdf . (Accessed 13 Oct 2022) + + + Shlobin NA, Jordan T. Roach JT, Kancherla V, Caceres A, Ocal E, Ghotme K, Lam S, Park KB, Rosseau G Blount JP, Boop FA (2022) The role of neurosurgeons in global public health: the case of folic acid fortification of staple foods to prevent spina bifida. J Neurosurg: Pediatrics. (2022). In Press + + + Caceres A, Blount JP, Messing-Jünger M, Chatterjee S, Fieggen G, Salomao JF (2021) The International Society for Pediatric Neurosurgery resolution on mandatory folic acid fortification of staple foods for prevention of spina bifida and anencephaly and associated disability and child mortality. Childs Nerv Syst 37(6):1809–1812 + + 10.1007/s00381-021-05191-y + 33942142 + + + + Kancherla V, Botto LD, Rowe LA, Shlobin NA, Caceres A, Arynchyna-Smith A, Zimmerman K, Blount J, Kibruyisfaw Z, Ghotme KA, Karmarkar S, Fieggen G, Roozen S, Oakley GP Jr, Rosseau G, Berry RJ (2022) Preventing birth defects, saving lives, and promoting health equity: an urgent call to action for universal mandatory food fortification with folic acid. Lancet Glob Health 10(7):e1053–e1057 + + 10.1016/S2214-109X(22)00213-3 + 35617975 + + + + Martinez H, Pachón H, Kancherla V, Oakley GP (2021) Food fortification with folic acid for prevention of spina bifida and anencephaly: the need for a paradigm shift in evidence evaluation for policy-making. Am J Epidemiol 190(10):1972–1976 + + 10.1093/aje/kwab061 + 33728445 + 8485149 + + + + Foege W (2011) House on fire: the fight to eradicate smallpox. University of California Press, Berkeley and Los Angeles, California + + + Kancherla V, Tsang B, Wagh K, Dixon M, Oakley GP Jr (2020) Modeling shows high potential of folic acid-fortified salt to accelerate global prevention of major neural tube defects. Birth Defects Res 112(18):1461–1474 + + 10.1002/bdr2.1769 + 32738033 + + + + +
+ + + 36917263 + + 2023 + 03 + 14 + +
+ + 1529-7268 + + + 2023 + Mar + 14 + + + Biology of reproduction + Biol Reprod + + METTL3 promotes proliferation of goat endometrial epithelial cells by regulating CTGF in an m6A-dependent manner. + ioad029 + 10.1093/biolre/ioad029 + + N6-methyladenosine (m6A), an epigenetic modification on RNAs, plays an important role in many physiological and pathological processes. However, the involvement of m6A in goat uterus during early pregnancy remains largely unknown. In this study, we found that the total m6A level was increasing in goat uterus as early pregnancy progressed. Methyltransferase-like 3 (METTL3) is a core catalytic subunit of the m6A methyltransferase. We thus determined the expression and regulation of METTL3 in goat uterus. METTL3 was highly expressed in the luminal and glandular epithelia from day 16 (D16) to D25 of pregnancy. And it could be up-regulated by estrogen and progesterone in goat uterus and primary endometrial epithelial cells (EECs). In EECs, knockdown or overexpression of METTL3 resulted in a significant decrease or increase of cell proliferation, respectively. METTL3 knockdown reduced the m6A level of not only total RNA but also connective tissue growth factor (CTGF) mRNA. Luciferase assay suggested that METTL3 might target the potential m6A sites in the 3'untranslated region (3'UTR) of CTGF mRNA. Moreover, METTL3 positively regulated CTGF expression, and CTGF knockdown significantly counteracted the promoting effect of METTL3 overexpression on EEC proliferation. Collectively, METTL3 is dynamically expressed in goat uterus and can affect EEC proliferation by regulating CTGF in an m6A-dependent manner. Our results will lay a foundation for further studying the crucial mechanism of METTL3-mediated m6A modification in goat uterus during early pregnancy. + © The Author(s) 2023. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. + + + + Sun + Ya + Y + + Key Laboratory of Animal Cellular and Genetic Engineering of Heilongjiang Province, College of Life Science, Northeast Agricultural University, Harbin 150030, China. + + + + Zhang + Xin-Cheng + XC + + Key Laboratory of Animal Cellular and Genetic Engineering of Heilongjiang Province, College of Life Science, Northeast Agricultural University, Harbin 150030, China. + + + + Li + Meng-Die + MD + + Key Laboratory of Animal Cellular and Genetic Engineering of Heilongjiang Province, College of Life Science, Northeast Agricultural University, Harbin 150030, China. + + + + Bu + Li-Ge + LG + + Key Laboratory of Animal Cellular and Genetic Engineering of Heilongjiang Province, College of Life Science, Northeast Agricultural University, Harbin 150030, China. + + + + Wang + Bo + B + + Key Laboratory of Animal Cellular and Genetic Engineering of Heilongjiang Province, College of Life Science, Northeast Agricultural University, Harbin 150030, China. + + + + Li + Ting-Yue + TY + + Key Laboratory of Animal Cellular and Genetic Engineering of Heilongjiang Province, College of Life Science, Northeast Agricultural University, Harbin 150030, China. + + + + Ding + Nai-Zheng + NZ + + Key Laboratory of Animal Resistance Biology of Shandong Province, College of Life Science, Shandong Normal University, Jinan 250014, China. + + + + Ni + Hua + H + + Key Laboratory of Animal Cellular and Genetic Engineering of Heilongjiang Province, College of Life Science, Northeast Agricultural University, Harbin 150030, China. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Biol Reprod + 0207224 + 0006-3363 + + IM + + CTGF + Early pregnancy + Goat uterus + METTL3 + m6A + +
+ + + + 2023 + 3 + 14 + 12 + 15 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917263 + 7077435 + 10.1093/biolre/ioad029 + + +
+ + + 36917265 + + 2023 + 03 + 14 + +
+ + 1618-2650 + + + 2023 + Mar + 14 + + + Analytical and bioanalytical chemistry + Anal Bioanal Chem + + Affinity-based electrochemical sensors for biomolecular detection in whole blood. + 10.1007/s00216-023-04627-5 + + The detection and/or quantification of biomarkers in blood is important for the early detection, diagnosis, and treatment of a variety of diseases and medical conditions. Among the different types of sensors for detecting molecular biomarkers, such as proteins, nucleic acids, and small-molecule drugs, affinity-based electrochemical sensors offer the advantages of high analytical sensitivity and specificity, fast detection times, simple operation, and portability. However, biomolecular detection in whole blood is challenging due to its highly complex matrix, necessitating sample purification (i.e., centrifugation), which involves the use of bulky, expensive equipment and tedious sample-handling procedures. To address these challenges, various strategies have been employed, such as purifying the blood sample directly on the sensor, employing micro-/nanoparticles to enhance the detection signal, and coating the electrode surface with blocking agents to reduce nonspecific binding, to improve the analytical performance of affinity-based electrochemical sensors without requiring sample pre-processing steps or laboratory equipment. In this article, we present an overview of affinity-based electrochemical sensor technologies that employ these strategies for biomolecular detection in whole blood. + © 2023. The Author(s). + + + + Wilkirson + Elizabeth C + EC + + Department of Mechanical Engineering, Rice University, 6100 Main St., Houston, TX, 77005, USA. + + + + Singampalli + Kavya L + KL + + Department of Bioengineering, Rice University, 6500 Main St., Houston, TX, 77030, USA. + + + Medical Scientist Training Program, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA. + + + + Li + Jiran + J + + Department of Mechanical Engineering, Rice University, 6100 Main St., Houston, TX, 77005, USA. + + + + Dixit + Desh Deepak + DD + + Department of Mechanical Engineering, Rice University, 6100 Main St., Houston, TX, 77005, USA. + + + + Jiang + Xue + X + + Department of Mechanical Engineering, Rice University, 6100 Main St., Houston, TX, 77005, USA. + + + + Gonzalez + Diego H + DH + + Department of Bioengineering, Rice University, 6500 Main St., Houston, TX, 77030, USA. + + + + Lillehoj + Peter B + PB + http://orcid.org/0000-0002-0289-2634 + + Department of Mechanical Engineering, Rice University, 6100 Main St., Houston, TX, 77005, USA. lillehoj@rice.edu. + + + Department of Bioengineering, Rice University, 6500 Main St., Houston, TX, 77030, USA. lillehoj@rice.edu. + + + + eng + + + Award # 1842494 + National Science Foundation + + + + + Journal Article + Review + + + 2023 + 03 + 14 + +
+ + Germany + Anal Bioanal Chem + 101134327 + 1618-2642 + + IM + + Biosensor + Diagnostics + Electrochemical + Immunosensor + Whole blood + +
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+ + + 36917268 + + 2023 + 03 + 14 + +
+ + 1433-0350 + + + 2023 + Mar + 14 + + + Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery + Childs Nerv Syst + + Angioarchitecture and genetic variants of spinal cord cavernous malformations and associated developmental venous anomalies: a case report. + 10.1007/s00381-023-05887-3 + + Cavernous malformations (CM) have long been considered congenital of central nervous system, while the mechanism of CMs detailed development process associated with genetic factors remains unclear. We reported an uncommon case which suffered spinal cord cavernous malformations. In this work, representative samples were obtained, and the sequenced results were described for the first time. A 9-year-old boy was found oblique shoulder with slightly weakness of left limbs; MRI indicated spinal cord cavernous malformations (CMs) located at the C4-C6 vertebral level. On genetic analysis, a shared mutation of PIK3CA (p.H1047R) in CMs and associated developmental venous anomalies (DVAs) was detected, with a different abundance (2% and 7%, respectively), and a somatic mutation of MAP3K3 (p.I441M) was detected in the CM tissue samples. This case provides better knowledge of the formation history and genetic triggers of the DVA-associated CMs. This evidence allows us to speculate the developmental history of the CM lesion: The DVA with PIK3CA mutation might be genetic precursor, and then the associated CM could be derived from terminal cell population of the DVA by acquiring a somatic mutation in MAP3K3. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Ren + Jian + J + + Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing, 100053, China. + + + China International Neuroscience Institute, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing, 100053, China. + + + National Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing, 100053, China. + + + + Hong + Tao + T + + Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing, 100053, China. + + + China International Neuroscience Institute, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing, 100053, China. + + + National Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing, 100053, China. + + + + Zhang + Hongqi + H + + Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing, 100053, China. xwzhanghq@163.com. + + + China International Neuroscience Institute, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing, 100053, China. xwzhanghq@163.com. + + + National Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing, 100053, China. xwzhanghq@163.com. + + + + eng + + + 82201440 + National Natural Science Foundation of China + + + + 81971113 + National Natural Science Foundation of China + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Childs Nerv Syst + 8503227 + 0256-7040 + + IM + + Case report + Genetic analysis + MAP3K3 + PIK3CA + Spinal cord cavernous malformations + +
+ + + + 2022 + 10 + 25 + + + 2023 + 02 + 14 + + + 2023 + 3 + 14 + 12 + 15 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917268 + 10.1007/s00381-023-05887-3 + 10.1007/s00381-023-05887-3 + + + + Hong T, Xiao X, Ren J et al (2021) Somatic MAP3K3 and PIK3CA mutations in sporadic cerebral and spinal cord cavernous malformations. Brain 144(9):2648–2658. https://doi.org/10.1093/brain/awab117 + + 10.1093/brain/awab117 + 33729480 + + + + Snellings DA, Hong CC, Ren AA et al (2021) Cerebral cavernous malformation: from mechanism to therapy. Circ Res 129(1):195–215.  https://doi.org/10.1161/CIRCRESAHA.121.318174 + + + Labauge P, Denier C, Bergametti F, Tournier-Lasserve E (2007) Genetics of cavernous angiomas. Lancet Neurol 6(3):237–244. https://doi.org/10.1016/S1474-4422(07)70053-4 + + 10.1016/S1474-4422(07)70053-4 + 17303530 + + + + Fischer A, Zalvide J, Faurobert E, Albiges-Rizo C, Tournier-Lasserve E (2013) Cerebral cavernous malformations: from CCM genes to endothelial cell homeostasis. Trends Mol Med 19(5):302–308. https://doi.org/10.1016/j.molmed.2013.02.004 + + 10.1016/j.molmed.2013.02.004 + 23506982 + + + + Peyre M, Miyagishima D, Bielle F et al (2021) Somatic PIK3CA mutations in sporadic cerebral cavernous malformations. N Engl J Med 385(11):996–1004. https://doi.org/10.1056/NEJMoa2100440 + + 10.1056/NEJMoa2100440 + 34496175 + 8606022 + + + + Snellings DA, Girard R, Lightle R et al (2022) Developmental venous anomalies are a genetic primer for cerebral cavernous malformations. Nat Cardiovasc Res 1:246–252. https://doi.org/10.1038/s44161-022-00035-7 + + 10.1038/s44161-022-00035-7 + 35355835 + 8958845 + + + + +
+ + + 36917269 + + 2023 + 03 + 14 + +
+ + 1433-0350 + + + 2023 + Mar + 14 + + + Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery + Childs Nerv Syst + + In reply to the letter to editor regarding "Fourth ventricle stent placement for treatment of type I Chiari malformation in children". + 10.1007/s00381-023-05911-6 + + We made a reply to the letter to editor regarding "Fourth ventricle stent placement for treatment of type I Chiari malformation in children" by Prof. Afshari. He gave some comments on the primary cause of low-lying cerebellar tonsils and the risk of the fourth ventricle stent (FVS). We make further explanation of our opinion on Chiari malformation and the value of FVS. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Sun + Peng + P + + Capital Medical University, Department of Neurosurgery, Xuanwu Hospital, Beijing, China. + + + + Zhou + Mading + M + + Capital Medical University, Department of Neurosurgery, Xuanwu Hospital, Beijing, China. + + + + Liu + Yutong + Y + + Capital Medical University, Department of Neurosurgery, Xuanwu Hospital, Beijing, China. + + + + Du + Jianxin + J + + Capital Medical University, Department of Neurosurgery, Xuanwu Hospital, Beijing, China. + + + + Zeng + Gao + G + + Capital Medical University, Department of Neurosurgery, Xuanwu Hospital, Beijing, China. zengrogoss@163.com. + + + + eng + + Letter + + + 2023 + 03 + 14 + +
+ + Germany + Childs Nerv Syst + 8503227 + 0256-7040 + + IM +
+ + + + 2023 + 01 + 22 + + + 2023 + 02 + 27 + + + 2023 + 3 + 14 + 12 + 15 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917269 + 10.1007/s00381-023-05911-6 + 10.1007/s00381-023-05911-6 + + + + Antkowiak L, Tabakow P (2021) Comparative Assessment of Three Posterior Fossa Decompression Techniques and Evaluation of the Evidence Supporting the Efficacy of Syrinx Shunting and Filum Terminale Sectioning in Chiari Malformation Type I. A Systematic Review and Network Meta-Analysis. World Neurosurg 152:31–43. https://doi.org/10.1016/j.wneu.2021.05.124 + + + Riordan CP, Scott RM (2018) Fourth ventricle stent placement for treatment of recurrent syringomyelia in patients with type I Chiari malformations. Journal of neurosurgery. Pediatrics 10 19;23(2):164–170. https://doi.org/10.3171/2018.7.PEDS18312s + + + Sharma H, Treiber JM, Bauer DF (2021) Chiari 1 and Hydrocephalus - A Review. Neurol India 69(Supplement):S362-S366. https://doi.org/10.4103/0028-3886.332274 + + + Park JK, Gleason PL, Madsen JR, Goumnerova LC, Scott RM (1997) Presentation and management of Chiari I malformation in children. Pediatr Neurosurg 26(4):190–196. https://doi.org/10.1159/000121190 + + 10.1159/000121190 + 9436829 + + + + +
+ + + 36917271 + + 2023 + 03 + 14 + +
+ + 1573-4838 + + 34 + 3 + + 2023 + Mar + 14 + + + Journal of materials science. Materials in medicine + J Mater Sci Mater Med + + Optimization of magnetic fluid hyperthermia protocols for the elimination of breast cancer cells MCF7 using Mn-Zn ferrite ferrofluid. + + 11 + + 10.1007/s10856-023-06715-5 + + The present study aimed to optimize magnetic fluid hyperthermia (MFH) protocols by standardizing MF incubation time, hyperthermic duration, magnetic field, and MFH sessions to achieve a better hyperthermic response for the profuse killing of human breast cancer cell cells MCF7. Magnetic nanoparticles and MF were characterized using XRD, VSM, and DLS. Induction heating was performed for 30 min at field strengths of 12.5 and 13.3 kA/m at a fixed frequency of 330 kHz with varying concentrations and incubation duration on MCF7 cells. Single and multiple sessions hyperthermia protocols were used to kill MCF7 cells and the cytotoxicity effect was analyzed using MTT assay. Single and multiple sessions MFH protocols were established to kill breast cancer cells utilizing 0.2 mg/mL MF at 13.3 kA/m field and 330 kHz frequency and maintaining the hyperthermic temperature of 43-45 °C for 30 min. The single session MFH revealed severe toxicity of MF leading to more than 75% of cell death after 24 h of MF incubation. Multiple sessions hyperthermia resulted in more than 90% killing of MCF7 cells after two consequent 3 h MF incubation with 3 h gap. Each 3 h of MF incubation was followed by 30 min of induction heating. Multiple sessions hyperthermia was effective in killing a larger cell population compared to the single session protocol. The results may help in optimizing protocols for the profuse killing of cancer cells of multiple origins, and aid in deciding futuristic in vivo MFH-based therapeutic strategies against breast cancer. Variation in MCF7 cells' viability due to HT, MF, and MF + HT in multiple sessions. + © 2023. The Author(s). + + + + Bhardwaj + Anand + A + + Dr. K C Patel R & D Centre, Charotar University of Science & Technology, CHARUSAT Campus, Changa- 388 421, Anand, India. + + + + Parekh + Kinnari + K + http://orcid.org/0000-0002-1566-2846 + + Dr. K C Patel R & D Centre, Charotar University of Science & Technology, CHARUSAT Campus, Changa- 388 421, Anand, India. kinnariparekh.rnd@charusat.ac.in. + + + + Jain + Neeraj + N + + P D Patel Institute of Applied Sciences, Charotar University of Science & Technology CHARUSAT Campus, Changa- 388 421, Anand, India. neerajjain.as@charusat.ac.in. + + + + eng + + + SERB/EMR/2016/001000 + Science and engineering research Board, India + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + J Mater Sci Mater Med + 9013087 + 0957-4530 + + IM +
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+ + + 36917270 + + 2023 + 03 + 14 + +
+ + 1432-2161 + + + 2023 + Mar + 14 + + + Skeletal radiology + Skeletal Radiol + + Musculoskeletal steroid injections in pregnancy: a review. + 10.1007/s00256-023-04320-9 + + Pregnant women experience a wide range of musculoskeletal pain disorders, which include general ailments occurring during pregnancy, exacerbation of pre-existing conditions, or pregnancy-specific pain/inflammatory conditions. There are significant concerns and knowledge gaps surrounding the safety, dosage, and potential long-term effects of several drugs used during pregnancy. Our article reviews the use of focal steroid injections during pregnancy. A mixture of case studies, meta-analyses, and randomised controlled trials have shown at least there is no adverse side effect to the mother or baby from maternal use of non-systemic injection during pregnancy and a significant improvement in symptoms of pain or paraesthesia can be achieved in patients that do not respond to more conservative measures. As with all patients, the use of steroid injection should be judged on a case-by-case basis to ensure that it is the most appropriate treatment choice. However, being pregnant should not be considered a contraindication to a single dose of non-systemic steroid administration, as these women can achieve significant symptomatic relief that reduces reliance on systemic medication and can significantly improve their quality of life. + © 2023. Crown. + + + + Filippini + Claire + C + + Oxford University Hospitals NHS Foundation Trust, Windmill Rd, Oxford, OX3 7LD, UK. + + + + Saran + Sonal + S + + Department of Radiodiagnosis, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India. + + + + Chari + Basavaraj + B + http://orcid.org/0000-0001-7369-4822 + + Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Foundation Trust, Windmill Rd, Oxford, OX3 7LD, UK. raj.chari@ouh.nhs.uk. + + + + eng + + Journal Article + Review + + + 2023 + 03 + 14 + +
+ + Germany + Skeletal Radiol + 7701953 + 0364-2348 + + IM + + Carpal tunnel syndrome in pregnancy + Joint injection in pregnancy + Musculoskeletal pain in pregnancy + Pregnancy + Steroid injection in pregnancy + +
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+ + + 36917295 + + 2023 + 03 + 14 + +
+ + 1573-9686 + + + 2023 + Mar + 14 + + + Annals of biomedical engineering + Ann Biomed Eng + + Padded Helmet Shell Covers in American Football: A Comprehensive Laboratory Evaluation with Preliminary On-Field Findings. + 10.1007/s10439-023-03169-2 + + Protective headgear effects measured in the laboratory may not always translate to the field. In this study, we evaluated the impact attenuation capabilities of a commercially available padded helmet shell cover in the laboratory and on the field. In the laboratory, we evaluated the padded helmet shell cover's efficacy in attenuating impact magnitude across six impact locations and three impact velocities when equipped to three different helmet models. In a preliminary on-field investigation, we used instrumented mouthguards to monitor head impact magnitude in collegiate linebackers during practice sessions while not wearing the padded helmet shell covers (i.e., bare helmets) for one season and whilst wearing the padded helmet shell covers for another season. The addition of the padded helmet shell cover was effective in attenuating the magnitude of angular head accelerations and two brain injury risk metrics (DAMAGE, HARM) across most laboratory impact conditions, but did not significantly attenuate linear head accelerations for all helmets. Overall, HARM values were reduced in laboratory impact tests by an average of 25% at 3.5 m/s (range: 9.7 to 39.6%), 18% at 5.5 m/s (range: - 5.5 to 40.5%), and 10% at 7.4 m/s (range: - 6.0 to 31.0%). However, on the field, no significant differences in any measure of head impact magnitude were observed between the bare helmet impacts and padded helmet impacts. Further laboratory tests were conducted to evaluate the ability of the padded helmet shell cover to maintain its performance after exposure to repeated, successive impacts and across a range of temperatures. This research provides a detailed assessment of padded helmet shell covers and supports the continuation of in vivo helmet research to validate laboratory testing results. + © 2023. The Author(s) under exclusive licence to Biomedical Engineering Society. + + + + Cecchi + Nicholas J + NJ + http://orcid.org/0000-0001-9319-4163 + + Department of Bioengineering, Stanford University, Stanford, CA, 94305, USA. + + + + Callan + Ashlyn A + AA + + Department of Bioengineering, Stanford University, Stanford, CA, 94305, USA. + + + + Watson + Landon P + LP + + Department of Bioengineering, Stanford University, Stanford, CA, 94305, USA. + + + + Liu + Yuzhe + Y + + Department of Bioengineering, Stanford University, Stanford, CA, 94305, USA. + + + + Zhan + Xianghao + X + + Department of Bioengineering, Stanford University, Stanford, CA, 94305, USA. + + + + Vegesna + Ramanand V + RV + + Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, 90089, USA. + + + + Pang + Collin + C + + Department of Bioengineering, Stanford University, Stanford, CA, 94305, USA. + + + + Le Flao + Enora + E + + Department of Bioengineering, Stanford University, Stanford, CA, 94305, USA. + + + + Grant + Gerald A + GA + + Department of Neurosurgery, Stanford University, Stanford, CA, 94305, USA. + + + Department of Neurology, Stanford University, Stanford, CA, 94305, USA. + + + Department of Neurosurgery, Duke University, Durham, NC, 27710, USA. + + + + Zeineh + Michael M + MM + + Department of Radiology, Stanford University, Stanford, CA, 94305, USA. + + + + Camarillo + David B + DB + + Department of Bioengineering, Stanford University, Stanford, CA, 94305, USA. dcamarillo@stanford.edu. + + + Department of Neurosurgery, Stanford University, Stanford, CA, 94305, USA. dcamarillo@stanford.edu. + + + Department of Mechanical Engineering, Stanford University, Stanford, CA, 94305, USA. dcamarillo@stanford.edu. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Ann Biomed Eng + 0361512 + 0090-6964 + + IM + + Brain injury + Concussion + Head kinematics + Headgear + Instrumented mouthguard + +
+ + + + 2022 + 11 + 29 + + + 2023 + 02 + 08 + + + 2023 + 3 + 14 + 12 + 16 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917295 + 10.1007/s10439-023-03169-2 + 10.1007/s10439-023-03169-2 + + + + Alosco, M. L., A. B. Kasimis, J. M. Stamm, A. S. Chua, C. M. Baugh, D. H. Daneshvar, C. A. Robbins, M. Mariani, J. Hayden, S. Conneely, and R. Au. Age of first exposure to American football and long-term neuropsychiatric and cognitive outcomes. Transl. Psychiatry. 7(9):e1236–e1236, 2017. + + 28926003 + 5639242 + 10.1038/tp.2017.197 + + + + Bailey, A. M., J. R. Funk, J. R. Crandall, B. S. Myers, and K. B. Arbogast. Laboratory evaluation of shell add-on products for American football helmets for professional linemen. Ann. Biomed. Eng. 49(10):2747–2759, 2021. + + 34378120 + 10.1007/s10439-021-02842-8 + + + + Bailey, A. M., T. L. McMurry, J. M. Cormier, J. R. Funk, J. R. Crandall, C. D. Mack, B. S. Myers, and K. B. Arbogast. Comparison of laboratory and on-field performance of American football helmets. Ann. Biomed. Eng. 48(11):2531–2541, 2020. + + 33025320 + 10.1007/s10439-020-02627-5 + + + + Bailey, A. M., E. J. Sanchez, G. Park, L. F. Gabler, J. R. Funk, J. R. Crandall, M. Wonnacott, C. Withnall, B. S. Myers, and K. B. Arbogast. Development and evaluation of a test method for assessing the performance of American football helmets. Ann. Biomed. Eng. 48(11):2566–2579, 2020. + + 33025321 + 10.1007/s10439-020-02626-6 + + + + Bliven, E., A. Rouhier, S. Tsai, R. Willinger, N. Bourdet, C. Deck, S. M. Madey, and M. Bottlang. Evaluation of a novel bicycle helmet concept in oblique impact testing. Accid. Anal. Prev. 124:58–65, 2019. + + 30634159 + 6743977 + 10.1016/j.aap.2018.12.017 + + + + Bonin, S. J., A. L. Demarco, and G. P. Siegmund. The effect of MIPS, headform condition, and impact orientation on headform kinematics across a range of impact speeds during oblique bicycle helmet impacts. Ann. Biomed. Eng. 50:860–870, 2022. + + 35441268 + 10.1007/s10439-022-02961-w + + + + Breedlove, K. M., E. Breedlove, E. Nauman, T. G. Bowman, and M. R. Lininger. The ability of an aftermarket helmet add-on device to reduce impact-force accelerations during drop tests. J. Athlet. Train. 52(9):802–808, 2017. + + 10.4085/1062-6050-52.6.01 + + + + Campolettano, E. T., and S. Rowson. Relating on-field youth football head impacts to pneumatic ram laboratory testing procedures. Proc. Inst. Mech. Eng. Part P. 235(1):62–69, 2021. + + + Cecchi, N. J., A. G. Domel, Y. Liu, E. Rice, R. Lu, X. Zhan, Z. Zhou, S. J. Raymond, S. Sami, H. Singh, and L. P. Watson. Identifying factors associated with head impact kinematics and brain strain in high school American football via instrumented mouthguards. Ann. Biomed. Eng. 49(10):2814–2826, 2021. + + 34549342 + 8906650 + 10.1007/s10439-021-02853-5 + + + + Cecchi, N. J., T. J. Oros, D. C. Monroe, G. M. Fote, W. X. Moscoso, J. W. Hicks, and D. J. Reinkensmeyer. The effectiveness of protective headgear in attenuating ball-to-forehead impacts in water polo. Front. Sports Act. Liv. 2019. https://doi.org/10.3389/fspor.2019.00002 . + + 10.3389/fspor.2019.00002 + + + + Cecchi, N. J., T. J. Oros, J. J. Ringhofer, and D. C. Monroe. Comparison of head impact attenuation capabilities between a standard American football helmet and novel protective equipment that couples a helmet and shoulder pads. Sports Eng. 22(3):1–8, 2019. + + + Choi, G. B., E. P. Smith, S. M. Duma, S. Rowson, E. Campolettano, M. E. Kelley, D. A. Jones, J. D. Stitzel, J. E. Urban, A. Genemaras, and J. G. Beckwith. Head impact exposure in youth and collegiate American football. Ann. Biomed. Eng. 50:1488, 2022. + + 35507229 + 10.1007/s10439-022-02974-5 + + + + Clark, J. M., K. Adanty, A. Post, T. B. Hoshizaki, A. N. Annaidh, and M. D. Gilchrist. A parametric analysis of factors that determine head injury outcomes following equestrian fall accidents. Int. J. 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A football helmet prototype that reduces linear and rotational acceleration with the addition of an outer shell. J. Neurosurg. 130(5):1634–1641, 2018. + + 10.3171/2018.1.JNS172733 + + + + +
+ + + 36917272 + + 2023 + 03 + 14 + +
+ + 1432-2013 + + + 2023 + Mar + 14 + + + Pflugers Archiv : European journal of physiology + Pflugers Arch + + Calcineurin-dependent regulation of gap junction conductance and connexin phosphorylation in guinea pig left atrium. + 10.1007/s00424-023-02798-9 + + Atrial fibrillation (AF) occurs from disordered atrial action potential conduction and is associated with reduced gap junction electrical conductance (Gj). The Ca2+ and calmodulin-dependent phosphatase, calcineurin, reduces Gj in ventricular myocardium via a protein phosphatase-1 (PP1)-dependent pathway culminating in phosphorylation of serine368 on connexin43 (pSer368-Cx43). However, characterisation of corresponding pathways in left atrial myocardium, which have a more complex connexin subtype profile, is undefined and was the aim of this study. Gj was measured in guinea-pig left atrium from the frequency-dependent variation of intracellular impedance; intracellular [Ca2+], ([Ca2+]i) in low-Na solution was measured by Fura-2 fluorescence. Phosphorylation of guinea-pig Ser368-Cx43 residues was measured by Western blot; Cx40 was immunoprecipitated and probed for serine/threonine residue phosphorylation. Low-Na solution reversibly reduced Gj, in turn attenuated or prevented by calcineurin inhibitors cyclosporin-A or CAIP, respectively. Moreover, Ser368-Cx43 phosphorylation in low-Na solution was also prevented by CAIP. Changes were partially prevented by fostreicin (FST), a protein phosphatase-2A (PP2A) inhibitor; but not by tautomycin, a PP1 inhibitor. Serine/threonine residues on Cx40 were also phosphorylated in low-Na solution; prevented by CAIP and attenuated by FST. Reduced Gj with raised [Ca2+]i is paralleled by a changed Cx43/Cx40 phosphorylation status; changes mediated by calcineurin and PP2A-dependent pathways, but not PP1. The pharmacological profile underlying changes to guinea-pig atrial gap junction electrical conductance with raised intracellular [Ca2+]i is fundamentally different from that in ventricular myocardium. This provides a targeted drug model whereby atrial and ventricular myocardium can be selectively targeted to correct conduction defects. + © 2023. The Author(s). + + + + Jabr + R I + RI + + Department of Neuroscience, Physiology & Pharmacology, University College London, London, UK. + + + + Salvage + S C + SC + + Department of Biochemistry, University of Cambridge, Cambridge, UK. + + + + Hatch + F S + FS + + Department of Biochemistry and Physiology, Surrey University, Guildford, UK. + + + + Fry + C H + CH + + School of Physiology, Pharmacology & Neuroscience, University of Bristol, Biomedical Sciences Building, University Walk, Bristol, BS8 1TD, UK. chris.fry@bristol.ac.uk. + + + + eng + + + H1 myocardium + HASTE + + + + H1 myocardium + HASTE + + + + H1 myocardium + HASTE + + + + H1 myocardium + HASTE + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Pflugers Arch + 0154720 + 0031-6768 + + IM + + Calcineurin + Connexin + Gap junction electrical conductance + Gap junctions + Left atrium + Phosphorylation + +
+ + + + 2022 + 09 + 29 + + + 2023 + 02 + 20 + + + 2023 + 02 + 18 + + + 2023 + 3 + 14 + 12 + 15 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917272 + 10.1007/s00424-023-02798-9 + 10.1007/s00424-023-02798-9 + + + + Link MS, Giugliano RP, Ruff CT, Scirica BM, Huikuri H, Oto A, Crompton AE, Murphy SA, Lanz H, Mercuri MF, Antman EM, Braunwald E, ENGAGE AF-TIMI 48 Investigators (2017) Stroke and mortality risk in patients with various patterns of atrial fibrillation. Circ Arrhythm Electrophysiol 10:e004267. https://doi.org/10.1161/CIRCEP.116.004267 + + 10.1161/CIRCEP.116.004267 + 28077507 + + + + Landstrom AP, Dobrev D, Wehrens XHT (2017) Calcium signaling and cardiac arrhythmias. 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+ + Germany + Arch Microbiol + 0410427 + 0302-8933 + + IM + + Antibiotics + Antimicrobial + ESKAPE + Multi-drug resistance + Pathogen + Plant + +
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+ + 1432-0614 + + + 2023 + Mar + 14 + + + Applied microbiology and biotechnology + Appl Microbiol Biotechnol + + Alleviating vacuolar transport improves cellulase production in Trichoderma reesei. + 10.1007/s00253-023-12478-4 + + Increasing cellulase production in cellulolytic fungus Trichoderma reesei is of interest for biofuels and biorefineries. Previous studies indicated that secreted protein was occasionally accumulated in vacuoles; this phenomenon has also been reported in T. reesei. Therefore, alleviating vacuolar transport seems to be a promising strategy for improving cellulase production in T. reesei. Herein, we found that knockout of vps10, vps13, and vps21, among 11 vacuolar protein sorting factors, improved cellulase production in T. reesei. The filter paper activity in Δvps10, Δvps13, and Δvps21 increased by 1.28-, 2.45-, and 2.11-fold than that of the parent strain. Moreover, the β-glucosidase activity in Δvps13 and Δvps21 increased by 3.22- and 3.56-fold after 6 days of fermentation. Furthermore, we also found that the vacuolar trafficking towards vacuoles was partially impaired in three knockout mutants, and disruption of vps13 alleviated the autophagy process. These results indicated that alleviated transport and degradation towards vacuole in Δvps10, Δvps13, and Δvps21 might improve cellulase production. Of note, the expression of cellulase genes in Δvps13 and Δvps21 was dramatically increased in the late induction phase compared to the parent. These results suggested that Vps13 and Vps21 might influence the cellulase production at transcription level. And further transcriptome analysis indicated that increased cellulase gene expression might be attributed to the differential expression of sugar transporters. Our study unravels the effect of alleviating vacuolar transport through knockout vps10, vps13, and vps21 for efficient cellulase secretion, providing new clues for higher cellulase production in T. reesei. KEY POINTS: • Disruption of vps10, vps13 or vps21 improves cellulase production • Vacuolar transport is impaired in three vps KO mutants • Deletion of vps13 or vps21 increases the transcript of cellulase genes in late stage. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Yan + Su + S + + Lab of Brewing Microbiology and Applied Enzymology, School of Biotechnology and Key Laboratory of Industrial Biotechnology of Ministry of Education, Jiangnan University, Wuxi, 214122, China. + + + + Xu + Yan + Y + + Lab of Brewing Microbiology and Applied Enzymology, School of Biotechnology and Key Laboratory of Industrial Biotechnology of Ministry of Education, Jiangnan University, Wuxi, 214122, China. + + + + Tao + Xiu-Mei + XM + + State Key Laboratory of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi, 214122, China. + + + + Yu + Xiao-Wei + XW + http://orcid.org/0000-0001-7967-6051 + + Lab of Brewing Microbiology and Applied Enzymology, School of Biotechnology and Key Laboratory of Industrial Biotechnology of Ministry of Education, Jiangnan University, Wuxi, 214122, China. yuxw@jiangnan.edu.cn. + + + + eng + + + 2021YFC2100203 + National Key Research and Development Program of China + + + + 32072162 + National Natural Science Foundation of China + + + + KYCX20_1819 + Postgraduate Research & Practice Innovation Program of Jiangsu Province + + + + LITE2018-09 + National First-Class Discipline Program of Light Industry Technology and Engineering + + + + 111-2-06 + 111Project + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Appl Microbiol Biotechnol + 8406612 + 0175-7598 + + IM + + Cellulase + Trichoderma reesei + Vacuolar protein sorting + Vps10 + Vps13 + Vps21 + +
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+ + + 36917274 + + 2023 + 03 + 14 + +
+ + 1432-0614 + + + 2023 + Mar + 14 + + + Applied microbiology and biotechnology + Appl Microbiol Biotechnol + + Improving the on-target activity of high-fidelity Cas9 editors by combining rational design and random mutagenesis. + 10.1007/s00253-023-12469-5 + + Genomic and post-genomic editors based on CRISPR/Cas systems are widely used in basic research and applied sciences, including human gene therapy. Most genome editing tools are based on the CRISPR/Cas9 type IIA system from Streptococcus pyogenes. Unfortunately, a number of drawbacks have hindered its application in therapeutic approaches, the most serious of which is the relatively high level of off-targets. To overcome this obstacle, various high-fidelity Cas9 variants have been created. However, they show reduced on-target activity compared to wild-type Cas9 possibly due to increased sensitivity to eukaryotic chromatin. Here, we combined a rational approach with random mutagenesis to create a set of new Cas9 variants showing high specificity and increased activity in Saccharomyces cerevisiae yeast. Moreover, a novel mutation in the PAM (protospacer adjacent motif)-interacting Cas9 domain was found, which increases the on-target activity of high-fidelity Cas9 variants while retaining their high specificity. The obtained data suggest that this mutation acts by weakening the eukaryotic chromatin barrier for Cas9 and rearranging the RuvC active center. Improved Cas9 variants should further advance genome and post-genome editing technologies. KEY POINTS: • D147Y and P411T mutations increase the activity of high-fidelity Cas9 variants. • The new L1206P mutation further increases the activity of high-fidelity Cas9 variants. • The L1206P mutation weakens the chromatin barrier for Cas9 editors. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Spasskaya + Daria S + DS + + Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology Russian Academy of Sciences, Vavilov St. 32, Moscow, 119991, Russia. + + + + Davletshin + Artem I + AI + + Engelhardt Institute of Molecular Biology Russian Academy of Sciences, Vavilov St. 32, Moscow, 119991, Russia. + + + + Bachurin + Stanislav S + SS + + FSBEI HE Rostov State Medical University Ministry of Health, Nakhichevanskiy Lane 29, Rostov-On-Don, 344022, Russia. + + + + Tutyaeva + Vera V + VV + + Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology Russian Academy of Sciences, Vavilov St. 32, Moscow, 119991, Russia. + + + + Garbuz + David G + DG + + Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology Russian Academy of Sciences, Vavilov St. 32, Moscow, 119991, Russia. + + + + Karpov + Dmitry S + DS + http://orcid.org/0000-0001-5203-0787 + + Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology Russian Academy of Sciences, Vavilov St. 32, Moscow, 119991, Russia. aleom@yandex.ru. + + + + eng + + + 22-14-00377 + Russian Science Foundation + + + + 075-15-2019-1660 + Ministry of Science and Higher Education of the Russian Federation + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Appl Microbiol Biotechnol + 8406612 + 0175-7598 + + IM + + CRISPR/Cas9 + Genome editing + High-fidelity Cas9 variants + On-target activity + +
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+ + + 36917281 + + 2023 + 03 + 14 + +
+ + 1436-6215 + + + 2023 + Mar + 14 + + + European journal of nutrition + Eur J Nutr + + Association of diet quality indices with serum and metabolic biomarkers in participants of the ORISCAV-LUX-2 study. + 10.1007/s00394-023-03095-y + + Diet quality is a critical modifiable factor related to health, including the risk of cardiometabolic complications. Rather than assessing the intake of individual food items, it is more meaningful to examine overall dietary patterns. This study investigated the adherence to common dietary indices and their association with serum/metabolic parameters of disease risk. + Dietary intakes of the general adult population (n = 1404, 25-79 years) were assessed by a validated food-frequency questionnaire (174 items). The French ANSES-Ciqual food composition database was used to compute nutrient intakes. Seven indicators were calculated to investigate participants' diet quality: the Alternative Healthy Eating Index (AHEI), Dietary Approaches to Stop Hypertension Score (DASH-S), Mediterranean Diet Score (MDS), Diet Quality Index-International (DQI-I), Dietary Inflammatory Index (DII), Dietary Antioxidant Index (DAI), and Naturally Nutrient-Rich Score (NNRS). Various serum/metabolic parameters were used in the validity and association analyses, including markers of inflammation, blood glucose, and blood lipid status. + Following linear regression models adjusted for confounders, the DASH-S was significantly associated with most metabolic parameters (14, e.g., inversely with blood pressure, triglycerides, urinary sodium, uric acid, and positively with serum vitamin D), followed by the DQI-I (13, e.g., total cholesterol, apo-A/B, uric acid, and blood pressure) and the AHEI (11, e.g., apo-A, uric acid, serum vitamin D, diastolic blood pressure and vascular age). + Food-group-based indices, including DASH-S, DQI-I, and AHEI, were good predictors for serum/metabolic parameters, while nutrient-based indices, such as the DAI or NNRS, were less related to biological markers and, thus, less suitable to reflect diet quality in a general population. + © 2023. The Author(s). + + + + Vahid + Farhad + F + + Nutrition and Health Research Group, Department of Precision Health, Luxembourg Institute of Health, rue 1 A-B Thomas Edison, 1445, Strassen, Luxembourg. + + + + Hoge + Axelle + A + + Department of Public Health, University of Liège, Liège, Belgium. + + + + Hébert + James R + JR + + South Carolina Statewide Cancer Prevention and Control Program and Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA. + + + Department of Nutrition, Connecting Health Innovations LLC (CHI), Columbia, SC, USA. + + + + Bohn + Torsten + T + http://orcid.org/0000-0002-7825-0697 + + Nutrition and Health Research Group, Department of Precision Health, Luxembourg Institute of Health, rue 1 A-B Thomas Edison, 1445, Strassen, Luxembourg. Torsten.bohn@lih.lu. + + + + ORISCAV working group*. + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Eur J Nutr + 100888704 + 1436-6207 + + IM + + Chronic disease risk + Diet quality scores + Dietary patterns + Inflammation + Non-communicable diseases + Oxidative stress + Systemic Immune-Inflammation Index (SII) + Type 2 diabetes + + + + Alkerwi + Ala'a + A + + + Noppe + Stephanie + S + + + Delagardelle + Charles + C + + + Beissel + Jean + J + + + Chioti + Anna + A + + + Stranges + Saverio + S + + + Schmit + Jean-Claude + JC + + + Lair + Marie-Lise + ML + + + D'Incau + Marylène + M + + + Pastore + Jessica + J + + + Aguayo + Gloria + G + + + Le Coroller + Gwenaëlle + G + + + Vaillant + Michel + M + + + Samouda + Hanen + H + + + Appenzeller + Brice + B + + + Malisoux + Laurent + L + + + Couffignal + Sophie + S + + + Gantenbein + Manon + M + + + Devaux + Yvan + Y + + + Huiart + Laetitia + L + + + Bejko + Dritan + D + + + Fagherazzi + Guy + G + + + Perquin + Magali + M + + + Ruiz-Castell + Maria + M + + + Ernens + Isabelle + I + + +
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+ + + 36917280 + + 2023 + 03 + 14 + +
+ + 1432-0428 + + + 2023 + Mar + 14 + + + Diabetologia + Diabetologia + + The effect of surgical weight loss on diabetes complications in individuals with class II/III obesity. + 10.1007/s00125-023-05899-3 + + The aim of this study was to determine the effect of bariatric surgery on diabetes complications in individuals with class II/III obesity (BMI > 35 kg/m2). + We performed a prospective cohort study of participants with obesity who underwent bariatric surgery. At baseline and 2 years following surgery, participants underwent metabolic phenotyping and diabetes complication assessments. The primary outcomes for peripheral neuropathy (PN) were a change in intra-epidermal nerve fibre density (IENFD, units = fibres/mm) at the distal leg and proximal thigh, the primary outcome for cardiovascular autonomic neuropathy (CAN) was a change in the expiration/inspiration (E/I) ratio, and the primary outcome for retinopathy was a change in the mean deviation on frequency doubling technology testing. + Among 127 baseline participants, 79 completed in-person follow-up (age 46.0 ± 11.3 years [mean ± SD], 73.4% female). Participants lost a mean of 31.0 kg (SD 18.4), and all metabolic risk factors improved except for BP and total cholesterol. Following bariatric surgery, one of the primary PN outcomes improved (IENFD proximal thigh, +3.4 ± 7.8, p<0.01), and CAN (E/I ratio -0.01 ± 0.1, p=0.89) and retinopathy (deviation -0.2 ± 3.0, p=0.52) were stable. Linear regression revealed that a greater reduction in fasting glucose was associated with improvements in retinopathy (mean deviation point estimate -0.7, 95% CI -1.3, -0.1). + Bariatric surgery may be an effective approach to reverse PN in individuals with obesity. The observed stability of CAN and retinopathy may be an improvement compared with the natural progression of these conditions; however, controlled trials are needed. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Reynolds + Evan L + EL + https://orcid.org/0000-0002-0138-8436 + + Department of Neurology, University of Michigan, Ann Arbor, MI, USA. + + + + Watanabe + Maya + M + + Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA. + + + + Banerjee + Mousumi + M + + Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA. + + + + Chant + Ericka + E + + Department of Neurology, University of Michigan, Ann Arbor, MI, USA. + + + + Villegas-Umana + Emily + E + + Department of Neurology, University of Michigan, Ann Arbor, MI, USA. + + + + Elafros + Melissa A + MA + + Department of Neurology, University of Michigan, Ann Arbor, MI, USA. + + + + Gardner + Thomas W + TW + + Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, USA. + + + Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA. + + + + Pop-Busui + Rodica + R + + Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA. + + + + Pennathur + Subramaniam + S + + Division of Nephrology, Department of Internal Medicine and Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA. + + + + Feldman + Eva L + EL + + Department of Neurology, University of Michigan, Ann Arbor, MI, USA. + + + + Callaghan + Brian C + BC + + Department of Neurology, University of Michigan, Ann Arbor, MI, USA. bcallagh@med.umich.edu. + + + + eng + + + U01AG057562 + U.S. Department of Health and Human Services + + + + U24DK115255 + National Institute of Diabetes and Digestive and Kidney Diseases + + + + 5R25NS089450 + National Institute of Neurological Disorders and Stroke + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Diabetologia + 0006777 + 0012-186X + + IM + + Bariatric surgery + Chronic kidney disease + Diabetes complications + Obesity + Peripheral neuropathy + +
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+ + 1432-8798 + + 168 + 4 + + 2023 + Mar + 14 + + + Archives of virology + Arch Virol + + Donald Millis McLean (1926-2022): a humble and devoted scientist. + + 110 + + 10.1007/s00705-023-05724-7 + + + Artsob + Harvey + H + + Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada. + + + + Calisher + Charles H + CH + + Center for Vector-borne Infectious Diseases, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, USA. calisher6920@gmail.com. + + + + Morens + David M + DM + + National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA. + + + + eng + + Editorial + + + 2023 + 03 + 14 + +
+ + Austria + Arch Virol + 7506870 + 0304-8608 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 15 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917282 + 10.1007/s00705-023-05724-7 + 10.1007/s00705-023-05724-7 + + + + Boswell R (2013) “Sister relives memories of deadly Powassan virus.”Ottawa Citizen Oct21 + + + McLean DM, Donahue WL (1959) Powassan virus: isolation of virus from a fatal case of encephalitis CMAJ 80:708 – 112 + + + McLean DM (1983) Yukon isolates of snowshoe hare virus, 1972–1982 in Calisher CH, Thompson WH (eds) California Serogroup Viruses. Progress in Clinical and Biological Research 247–256 + + + +
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+ + 1436-2236 + + + 2023 + Mar + 14 + + + Marine biotechnology (New York, N.Y.) + Mar Biotechnol (NY) + + Generation of Albino Phenotype in Ornamental Fish by CRISPR/Cas9-Mediated Genome Editing of slc45a2 Gene. + 10.1007/s10126-023-10204-9 + + Albinism is the most common color variation described in fish and is a fascinating trait of some ornamental fish species. Albino mutants can be generated by knocking out core genes affecting melanin synthesis like slc45a2 in several fish species. However, genetic mutation remains challenging for species with unknown genome information. In this study, we generated albino mutants in two selected ornamental fish species, royal farlowella (Sturisoma panamense), and redhead cichlid (Vieja melanura). For this purpose, we carried out phylogenetic analyses of fish slc45a2 sequences and identified a highly conserved region among different fish species. A pair of degenerate primers spanning this region was designed and used to amplify a conserved slc45a2 fragment of 340 bp from the two fish species. Based on the amplified sequences, a target site in the 6th exon was used for designing guide RNA and this targeted site was first verified by the CRISPR/Cas9 system in the zebrafish (Danio rerio) model for the effectiveness. Then, specific guide RNAs were designed for the two ornamental fish species and tested. Most of the injected larvae completely lost black pigment over the whole body and eyes. DNA sequencing confirmed a high degree of mutation at the targeted site. Overall, we described a fast and efficient method to generate albino phenotype in fish species by targeting the conserved 6th exon of slc45a2 gene for genome editing via CRISPR/Cas9 and this approach could be a new genetic tool to generate desirable albino ornamental fish. + © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. + + + + Zhang + Changqing + C + + Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Shandong Provincial Maternal and Child Health Care Hospital, 250014, Jinan, China. Zhan0396@e.ntu.edu.sg. + + + Department of Biological Sciences, National University of Singapore, 14 Sciences Drive 4, 117558, Singapore, Singapore. Zhan0396@e.ntu.edu.sg. + + + + Ren + Ziheng + Z + + Department of Biological Sciences, National University of Singapore, 14 Sciences Drive 4, 117558, Singapore, Singapore. + + + + Gong + Zhiyuan + Z + + Department of Biological Sciences, National University of Singapore, 14 Sciences Drive 4, 117558, Singapore, Singapore. dbsgzy@nus.edu.sg. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Mar Biotechnol (NY) + 100892712 + 1436-2228 + + IM + + Albino + CRISPR/Cas9 + Ornamental fish + slc45a2 + +
+ + + + 2022 + 12 + 08 + + + 2023 + 02 + 27 + + + 2023 + 3 + 14 + 12 + 15 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917276 + 10.1007/s10126-023-10204-9 + 10.1007/s10126-023-10204-9 + + + + Antinucci P, Hindges R (2016) A crystal-clear zebrafish for in vivo imaging. Sci Rep 6:29490 + + 10.1038/srep29490 + 27381182 + 4933947 + + + + Bian C, Li R, Wen Z, Ge W, Shi Q (2021) Phylogenetic analysis of core melanin synthesis genes provides novel insights into the molecular basis of albinism in fish. Front Genet 12:707228 + + 10.3389/fgene.2021.707228 + 34422008 + 8371935 + + + + Blanc JM, P. H. (2003) Expression of family differences through within-lot competition in juvenile rainbow trout Oncorhynchus mykiss. J World Aquac Soc 34:425–432 + + 10.1111/j.1749-7345.2003.tb00081.x + + + + Blitz IL, Biesinger J, Xie X, Cho KW (2013) Biallelic genome modification in F(0) Xenopus tropicalis embryos using the CRISPR/Cas system. 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Zebrafish 18:235–242 + + 10.1089/zeb.2021.0011 + 34077687 + 8392167 + + + + Dooley CM, Schwarz H, Mueller KP, Mongera A, Konantz M, Neuhauss SC, Nusslein-Volhard C, Geisler R (2013) Slc45a2 and V-ATPase are regulators of melanosomal pH homeostasis in zebrafish, providing a mechanism for human pigment evolution and disease. Pigment Cell Melanoma Res 26:205–217 + + 10.1111/pcmr.12053 + 23205854 + + + + Edvardsen RB, Leininger S, Kleppe L, Skaftnesmo KO, Wargelius A (2014) Targeted mutagenesis in Atlantic salmon (Salmo salar L.) using the CRISPR/Cas9 system induces complete knockout individuals in the F0 generation. PLoS ONE 9:e108622 + + 10.1371/journal.pone.0108622 + 25254960 + 4177897 + + + + Gong Z, Wan H, Tay TL, Wang H, Chen M, Yan T (2003) Development of transgenic fish for ornamental and bioreactor by strong expression of fluorescent proteins in the skeletal muscle. Biochem Biophys Res Commun 308:58–63 + + 10.1016/S0006-291X(03)01282-8 + 12890479 + + + + Graf J, Voisey J, Hughes I, van Daal A (2007) Promoter polymorphisms in the MATP (SLC45A2) gene are associated with normal human skin color variation. Hum Mutat 28:710–717 + + 10.1002/humu.20504 + 17358008 + + + + Hattori RS, Yoshinaga TT, Butzge AJ, Hattori-Ihara S, Tsukamoto RY, Takahashi NS, Tabata YA (2020) Generation of a white-albino phenotype from cobalt blue and yellow-albino rainbow trout (Oncorhynchus mykiss): Inheritance pattern and chromatophores analysis. PLoS ONE 15:e0214034 + + 10.1371/journal.pone.0214034 + 31986190 + 6984684 + + + + Henning F, Renz AJ, Fukamachi S, Meyer A (2010) Genetic, comparative genomic, and expression analyses of the Mc1r locus in the polychromatic Midas cichlid fish (Teleostei, Cichlidae Amphilophus sp.) species group. J Mol Evol 70:405–412 + + 10.1007/s00239-010-9340-4 + 20449580 + + + + Jao LE, Wente SR, Chen W (2013) Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system. Proc Natl Acad Sci U S A 110:13904–13909 + + 10.1073/pnas.1308335110 + 23918387 + 3752207 + + + + Jeong CB, Kang HM, Hong SA, Byeon E, Lee JS, Lee YH, Choi IY, Bae S, Lee JS (2020) Generation of albino via SLC45a2 gene targeting by CRISPR/Cas9 in the marine medaka Oryzias melastigma. Mar Pollut Bull 154:111038 + + 10.1016/j.marpolbul.2020.111038 + 32174491 + + + + Karlson CKS, Mohd-Noor SN, Nolte N, Tan BC (2021) CRISPR/dCas9-based systems: Mechanisms and applications in plant sciences. Plants 10:2055. https://doi.org/10.3390/plants10102055 + + 10.3390/plants10102055 + 34685863 + 8540305 + + + + Kelsh RN, Brand M, Jiang YJ, Heisenberg CP, Lin S, Haffter P, Odenthal J, Mullins MC, van Eeden FJ, Furutani-Seiki M, Granato M, Hammerschmidt M, Kane DA, Warga RM, Beuchle D, Vogelsang L, Nusslein-Volhard C (1996) Zebrafish pigmentation mutations and the processes of neural crest development. Development 123:369–389 + + 10.1242/dev.123.1.369 + 9007256 + + + + Kotani H, Taimatsu K, Ohga R, Ota S, Kawahara A (2015) Efficient multiple genome modifications induced by the crRNAs, tracrRNA and Cas9 protein complex in zebrafish. PLoS ONE 10:e0128319 + + 10.1371/journal.pone.0128319 + 26010089 + 4444095 + + + + Kratochwil CF, Sefton MM, Meyer A (2015) Embryonic and larval development in the Midas cichlid fish species flock (Amphilophus spp.): a new evo-devo model for the investigation of adaptive novelties and species differences. BMC Dev Biol 15:12. https://doi.org/10.1186/s12861-015-0061-1 + + + Lamason RL, Mohideen MA, Mest JR, Wong AC, Norton HL, Aros MC, Jurynec MJ, Mao X, Humphreville VR, Humbert JE, Sinha S, Moore JL, Jagadeeswaran P, Zhao W, Ning G, Makalowska I, McKeigue PM, O’Donnell D, Kittles R, Parra EJ, Mangini NJ, Grunwald DJ, Shriver MD, Canfield VA, Cheng KC (2005) SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans. Science 310:1782–1786 + + 10.1126/science.1116238 + 16357253 + + + + Lang M, Orgogozo V (2011) Identification of homologous gene sequences by PCR with degenerate primers. Methods Mol Biol 772:245–256 + + 10.1007/978-1-61779-228-1_14 + 22065442 + + + + Li Z, Ptak D, Zhang L, Walls EK, Zhong W, Leung YF (2012) Phenylthiourea specifically reduces zebrafish eye size. 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+ + + 36917277 + + 2023 + 03 + 14 + +
+ + 1433-9285 + + + 2023 + Mar + 14 + + + Social psychiatry and psychiatric epidemiology + Soc Psychiatry Psychiatr Epidemiol + + Patterns and predictors of depressive and anxiety symptoms within a population-based sample of adults diagnosed with COVID-19 in Michigan. + 10.1007/s00127-023-02453-9 + + The COVID-19 pandemic has had wide-ranging impacts on mental health, however, less is known about predictors of mental health outcomes among adults who have experienced a COVID-19 diagnosis. We examined the intersection of demographic, economic, and illness-related predictors of depressive and anxiety symptoms within a population-based sample of adults diagnosed with COVID-19 in the U.S. state of Michigan early in the pandemic. + Data were from a population-based survey of Michigan adults who experienced a COVID-19 diagnosis prior to August 1, 2020 (N = 1087). We used weighted prevalence estimates and multinomial logistic regression to examine associations between mental health outcomes (depressive symptoms, anxiety symptoms, and comorbid depressive/anxiety symptoms) and demographic characteristics, pandemic-associated changes in accessing basic needs (accessing food/clean water and paying important bills), self-reported COVID-19 symptom severity, and symptom duration. + Relative risks for experiencing poor mental health outcomes varied by sex, age, race/ethnicity, and income. In adjusted models, experiencing a change in accessing basic needs associated with the pandemic was associated with higher relative risks for anxiety and comorbid anxiety/depressive symptoms. Worse COVID-19 symptom severity was associated with a higher burden of comorbid depressive/anxiety symptoms. "Long COVID" (symptom duration greater than 60 days) was associated with all outcomes. + Adults diagnosed with COVID-19 may face overlapping risk factors for poor mental health outcomes, including pandemic-associated disruptions to household and economic wellbeing, as well as factors related to COVID-19 symptom severity and duration. An integrated approach to treating depressive/anxiety symptoms among COVID-19 survivors is warranted. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany. + + + + Titus + Andrea R + AR + http://orcid.org/0000-0001-7586-643X + + Department of Population Health, NYU Grossman School of Medicine, 180 Madison Avenue, New York, NY, 10016, USA. andrea.titus@nyulangone.org. + + + + Mezuk + Briana + B + + Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA. + + + + Hirschtick + Jana L + JL + + Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA. + + + + McKane + Patricia + P + + Lifecourse Epidemiology and Genomics Division, Michigan Department of Health and Human Services, Lansing, MI, USA. + + + + Elliott + Michael R + MR + + Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA. + + + Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA. + + + + Fleischer + Nancy L + NL + + Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA. + + + + eng + + + T32HS026120 + Agency for Healthcare Research and Quality + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Soc Psychiatry Psychiatr Epidemiol + 8804358 + 0933-7954 + + IM + + Anxiety + COVID-19 + Depression + Epidemiology + Mental health + +
+ + + + 2022 + 02 + 14 + + + 2023 + 02 + 27 + + + 2023 + 3 + 14 + 12 + 15 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917277 + 10.1007/s00127-023-02453-9 + 10.1007/s00127-023-02453-9 + + + + Holmes EA, O’Connor RC, Perry VH et al (2020) Multidisciplinary research priorities for the COVID-19 pandemic: a call for action for mental health science. Lancet Psychiatry. https://doi.org/10.1016/S2215-0366(20)30168-1 + + 10.1016/S2215-0366(20)30168-1 + 32563319 + 7302786 + + + + Kumar A, Nayar KR (2021) COVID 19 and its mental health consequences. J Ment Health 30:1–2. https://doi.org/10.1080/09638237.2020.1757052 + + 10.1080/09638237.2020.1757052 + 32339041 + + + + Rajkumar RP (2020) COVID-19 and mental health: a review of the existing literature. Asian J Psychiatry 52:102066. https://doi.org/10.1016/j.ajp.2020.102066 + + 10.1016/j.ajp.2020.102066 + + + + Torales J, O’Higgins M, Castaldelli-Maia JM, Ventriglio A (2020) The outbreak of COVID-19 coronavirus and its impact on global mental health. Int J Soc Psychiatry 66:317–320. https://doi.org/10.1177/0020764020915212 + + 10.1177/0020764020915212 + 32233719 + + + + Xiong J, Lipsitz O, Nasri F et al (2020) Impact of COVID-19 pandemic on mental health in the general population: a systematic review. J Affect Disord 277:55–64. https://doi.org/10.1016/j.jad.2020.08.001 + + 10.1016/j.jad.2020.08.001 + 32799105 + 7413844 + + + + Czeisler MÉ, Lane RI, Petrosky E et al (2020) Mental health, substance use, and suicidal ideation during the COVID-19 pandemic — United States, June 24–30, 2020. 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+ + 1432-0614 + + + 2023 + Mar + 14 + + + Applied microbiology and biotechnology + Appl Microbiol Biotechnol + + Extracellular vesicles in COVID-19 prognosis, treatment, and vaccination: an update. + 10.1007/s00253-023-12468-6 + + The lethality of the COVID 19 pandemic became the trigger for one of the most meteoric races on record in the search for strategies of disease control. Those include development of rapid and sensitive diagnostic methods, therapies to treat severe cases, and development of anti-SARS-CoV-2 vaccines, the latter responsible for the current relative control of the disease. However, the commercially available vaccines are still far from conferring protection against acquiring the infection, so the development of more efficient vaccines that can cut the transmission of the variants of concerns that currently predominate and those that will emerge is a prevailing need. On the other hand, considering that COVID 19 is here to stay, the development of new diagnosis and treatment strategies is also desirable. In this sense, there has recently been a great interest in taking advantage of the benefits offered by extracellular vesicles (EVs), membrane structures of nanoscale size that carry information between cells participating in this manner in many physiological homeostatic and pathological processes. The interest has been focused on the fact that EVs are relatively easy to obtain and manipulate, allowing the design of natural nanocarriers that deliver molecules of interest, as well as the information about the pathogens, which can be exploited for the aforementioned purposes. Studies have shown that infection with SARS-CoV-2 induces the release of EVs from different sources, including platelets, and that their increase in blood, as well as some of their markers, could be used as a prognosis of disease severity. Likewise, EVs from different sources are being used as the ideal carriers for delivering active molecules and drugs to treat the disease, as well as vaccine antigens. In this review, we describe the progress that has been made in these three years of pandemic regarding the use of EVs for diagnosis, treatment, and vaccination against SARS-CoV-2 infection. KEY POINTS: • Covid-19 still requires more effective and specific treatments and vaccines. • The use of extracellular vesicles is emerging as an option with multiple advantages. • Association of EVs with COVID 19 and engineered EVs for its control are presented. + © 2023. The Author(s). + + + + Hernández-Díazcouder + Adrián + A + + Departamento de Inmunología, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, México. + + + Departamento de Ciencias de La Salud, Universidad Tecnológica de México (UNITEC), Estado de México, Los Reyes, México. + + + + Díaz-Godínez + César + C + + Departamento de Ciencias de La Salud, Universidad Tecnológica de México (UNITEC), Estado de México, Los Reyes, México. + + + Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), 04510, Ciudad de México, México. + + + + Carrero + Julio César + JC + http://orcid.org/0000-0003-1055-5774 + + Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), 04510, Ciudad de México, México. carrero@iibiomedicas.unam.mx. + + + + eng + + + IN208020 + Programa de Apoyo a Proyectos de Investigación e Innovación Tecnológica + + + + + Journal Article + Review + + + 2023 + 03 + 14 + +
+ + Germany + Appl Microbiol Biotechnol + 8406612 + 0175-7598 + + IM + + COVID-19 + Extracellular vesicles + Prognosis + SARS-CoV-2 + Treatment + Vaccination + +
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+ + + 36917279 + + 2023 + 03 + 14 + +
+ + 1432-0428 + + + 2023 + Mar + 14 + + + Diabetologia + Diabetologia + + Upregulated TGF-β1 contributes to hyperglycaemia in type 2 diabetes by potentiating glucagon signalling. + 10.1007/s00125-023-05889-5 + + Glucagon-stimulated hepatic gluconeogenesis contributes to endogenous glucose production during fasting. Recent studies suggest that TGF-β is able to promote hepatic gluconeogenesis in mice. However, the physiological relevance of serum TGF-β levels to human glucose metabolism and the mechanism by which TGF-β enhances gluconeogenesis remain largely unknown. As enhanced gluconeogenesis is a signature feature of type 2 diabetes, elucidating the molecular mechanisms underlying TGF-β-promoted hepatic gluconeogenesis would allow us to better understand the process of normal glucose production and the pathophysiology of this process in type 2 diabetes. This study aimed to investigate the contribution of upregulated TGF-β1 in human type 2 diabetes and the molecular mechanism underlying the action of TGF-β1 in glucose metabolism. + Serum levels of TGF-β1 were measured by ELISA in 74 control participants with normal glucose tolerance and 75 participants with type 2 diabetes. Human liver tissue was collected from participants without obesity and with or without type 2 diabetes for the measurement of TGF-β1 and glucagon signalling. To investigate the role of Smad3, a key signalling molecule downstream of the TGF-β1 receptor, in mediating the effect of TGF-β1 on glucagon signalling, we generated Smad3 knockout mice. Glucose levels in Smad3 knockout mice were measured during prolonged fasting and a glucagon tolerance test. Mouse primary hepatocytes were isolated from Smad3 knockout and wild-type (WT) mice to investigate the underlying molecular mechanisms. Smad3 phosphorylation was detected by western blotting, levels of cAMP were detected by ELISA and levels of protein kinase A (PKA)/cAMP response element-binding protein (CREB) phosphorylation were detected by western blotting. The dissociation of PKA subunits was measured by immunoprecipitation. + We observed higher levels of serum TGF-β1 in participants without obesity and with type 2 diabetes than in healthy control participants, which was positively correlated with HbA1c and fasting blood glucose levels. In addition, hyperactivation of the CREB and Smad3 signalling pathways was observed in the liver of participants with type 2 diabetes. Treating WT mouse primary hepatocytes with TGF-β1 greatly potentiated glucagon-stimulated PKA/CREB phosphorylation and hepatic gluconeogenesis. Mechanistically, TGF-β1 treatment induced the binding of Smad3 to the regulatory subunit of PKA (PKA-R), which prevented the association of PKA-R with the catalytic subunit of PKA (PKA-C) and led to the potentiation of glucagon-stimulated PKA signalling and gluconeogenesis. + The hepatic TGF-β1/Smad3 pathway sensitises the effect of glucagon/PKA signalling on gluconeogenesis and synergistically promotes hepatic glucose production. Reducing serum levels of TGF-β1 and/or preventing hyperactivation of TGF-β1 signalling could be a novel approach for alleviating hyperglycaemia in type 2 diabetes. + © 2023. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply. + + + + Xiao + Yang + Y + + National Clinical Research Center for Metabolic Diseases, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China. + + + Key Laboratory of Diabetes Immunology, Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China. + + + + Wang + Yanfei + Y + + National Clinical Research Center for Metabolic Diseases, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China. + + + Key Laboratory of Diabetes Immunology, Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China. + + + Department of Endocrinology, The First People's Hospital of Foshan, Foshan, China. + + + + Ryu + Jiyoon + J + + Department of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX, USA. + + + + Liu + Wei + W + + National Clinical Research Center for Metabolic Diseases, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China. + + + Key Laboratory of Diabetes Immunology, Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China. + + + Division of Biliopancreatic Surgery and Bariatric Surgery, Department of General Surgery, The Second Xiangya Hospital of Central South University, Changsha, China. + + + + Zou + Hailan + H + + National Clinical Research Center for Metabolic Diseases, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China. + + + Key Laboratory of Diabetes Immunology, Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China. + + + + Zhang + Rong + R + + National Clinical Research Center for Metabolic Diseases, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China. + + + Key Laboratory of Diabetes Immunology, Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China. + + + + Yan + Yin + Y + + National Clinical Research Center for Metabolic Diseases, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China. + + + Key Laboratory of Diabetes Immunology, Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China. + + + + Dai + Zhe + Z + + Department of Endocrinology, Zhongnan Hospital of Wuhan University, Wuhan, China. + + + + Zhang + Deling + D + + Department of Pathophysiology, Wuhan University School of Basic Medical Sciences, Wuhan, China. + + + + Sun + Lu-Zhe + LZ + + Department of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX, USA. + + + + Liu + Feng + F + + National Clinical Research Center for Metabolic Diseases, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China. + + + Metabolic Syndrome Research Center, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China. + + + + Zhou + Zhiguang + Z + + National Clinical Research Center for Metabolic Diseases, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China. zhouzhiguang@csu.edu.cn. + + + Key Laboratory of Diabetes Immunology, Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China. zhouzhiguang@csu.edu.cn. + + + + Dong + Lily Q + LQ + + Department of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX, USA. dongq@uthscsa.edu. + + + + eng + + + 2021A1515110995 + Basic and Applied Basic Research Foundation of Guangdong Province + + + + 2020001005311 + the Innovation project of Foshan Science and Technology Bureau + + + + 2020JJ3056 + the National Science Foundation of Hunan Province for Excellent Young Scholars + + + + 82270891 + National Natural Science Foundation of China + + + + 2018YFE0114500 + National Key Research and Development Project + + + + 2021RC 3032 + the science and technology innovation Program of Hunan Province + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Diabetologia + 0006777 + 0012-186X + + IM + + Glucagon + Hepatocytes + Hyperglycaemia + TGF-β + Type 2 diabetes + +
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+ + + 36917290 + + 2023 + 03 + 14 + +
+ + 1432-1076 + + + 2023 + Mar + 14 + + + European journal of pediatrics + Eur J Pediatr + + Prevalence, severity, and predictors of malnutrition in Indian children with cerebral palsy and their impact on health-related quality of life. + 10.1007/s00431-023-04930-4 + + Although several studies have shown that undernutrition is frequent in children with cerebral palsy (CP), studies determining predictors of undernutrition and its impact on health-related quality of life (HRQoL) are scarce. This study aimed to assess the prevalence, severity, and predictors of malnutrition in children with CP and its impact on quality of life. This prospective study was performed between August 2019 and December 2021 in children with a clinical diagnosis of CP aged 2-18 years. We also intended to determine the socio-demographic and clinical predictors of undernutrition in these children and its impact on HRQoL, measured by the cerebral palsy quality of life (CPQoL)-Primary Caregiver reported version. Out of 569 (5.4 ± 2.8 years of age, 74% boys) children with CP, 71%, 44%, and 72% children were underweight, wasted, and stunted respectively, whereas 22%, 11%, and 21% were severely underweight, wasted and stunted respectively. Lower socioeconomic status, higher Gross Motor Function Classification System, and Manual Ability Classification System level were found to be significantly associated with the severity of stunting and underweight (p < 0.05), but not with wasting. CPQoL score in children with CP aged > 4 years was lower in patients with severe wasting, stunting, and underweight, as compared to their rest of the counterparts when adjusted for socio-demographic and other clinical variables (p < 0.05).  Conclusion: Chronic undernutrition is more common than severe acute malnutrition in children with CP. The severity of undernutrition is an important predictor of impaired HRQoL in children with CP. What is Known: • Several studies have shown that undernutrition is frequent in children with cerebral palsy; however, studies determining predictors of undernutrition and its impact on health-related quality of life are scarce. What is New: • Our study identifies that lower socioeconomic status, higher Gross Motor Function Classification System, and Manual Ability Classification System level are significantly associated with the severity of stunting and being underweight. • Chronic undernutrition is more common than severe acute malnutrition in children with cerebral palsy. Its severity is an important predictor of impaired health-related quality of life in children with cerebral palsy. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Sharawat + Indar Kumar + IK + + Pediatric Neurology Division, Department of Pediatrics, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, 249203, India. + + + + Ramachandran + Aparna + A + + Department of Neurology, IQRAA International Hospital & Research Centre, Kozhikode, Kerala, 673009, India. + + + + Panda + Prateek Kumar + PK + + Pediatric Neurology Division, Department of Pediatrics, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, 249203, India. drprateekpanda@gmail.com. + + + + Kumar + Vinod + V + + Department of Pediatrics, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, 249203, India. + + + + Bhat + Nowneet Kumar + NK + + Department of Pediatrics, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, 249203, India. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Eur J Pediatr + 7603873 + 0340-6199 + + IM + + Cerebral palsy + Malnutrition + Neurological disorder + Quality of life + Severe acute malnutrition + Undernutrition + +
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+ + + 36917285 + + 2023 + 03 + 14 + +
+ + 1432-1068 + + + 2023 + Mar + 14 + + + European journal of orthopaedic surgery & traumatology : orthopedie traumatologie + Eur J Orthop Surg Traumatol + + Do associated proximal fibula fractures help predict the severity of tibial plateau fractures? + 10.1007/s00590-023-03513-1 + + Proximal fibula fractures are often associated with tibial plateau fractures, but their relationship is poorly characterized. The purpose of this study was to better define the relationship between tibial plateau injury severity and presence of associated soft tissue injuries. + A retrospective review was performed on all operatively treated tibial plateau fractures at a Level 1 trauma center over a 5-year period. Patient demographics, injury radiographs, CT scans, operative reports and follow-up were reviewed. + Queried tibial plateau fractures from 2014 to 2019 totaled 217 fractures in 215 patients. Fifty-two percent were classified as AO/OTA 41B and 48% were AO/OTA 41C. Thirty-nine percent had an associated proximal fibula fracture. The presence of a proximal fibula fracture had significant correlation with AO/OTA 41C fractures, as compared with AO/OTA 41B fractures (chi-square, p < 0.001). Of the patients with a lateral split depression type tibial plateau fracture, the presence of a proximal fibula fracture was associated with more articular comminution, measured by number of articular fragments (mean = 4.0 vs. 2.9 articular fragments, p = 0.004). There was also a higher rate of meniscal injury in patients with proximal fibula fractures (37% vs. 20%, p = 0.003). + There was a significant relationship between the higher energy tibial plateau fracture type (AO/OTA 41C) and the presence of an associated proximal fibula fracture. The presence of a proximal fibula fracture with a tibial plateau fracture is an indicator of a higher energy injury and a higher likelihood of meniscal injury. + © 2023. The Author(s). + + + + Mackie + Duncan B + DB + + Anne and Robert H. Lurie Children's Hospital of Chicago, Chicago, USA. + + + + Mitchell + Brendon C + BC + + Department of Orthopedic Surgery, University of California, 200 West Arbor Drive, San Diego, CA, 92103, USA. + + + + Siow + Matthew Y + MY + + Department of Orthopedic Surgery, University of California, 200 West Arbor Drive, San Diego, CA, 92103, USA. + + + + Onodera + Keenan M + KM + + Department of Orthopedic Surgery, University of California, 200 West Arbor Drive, San Diego, CA, 92103, USA. + + + + Berger + Garrett K + GK + + Department of Orthopedic Surgery, University of California, 200 West Arbor Drive, San Diego, CA, 92103, USA. + + + + Kent + William T + WT + http://orcid.org/0000-0002-7065-9551 + + Department of Orthopedic Surgery, University of California, 200 West Arbor Drive, San Diego, CA, 92103, USA. wkent@health.ucsd.edu. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + France + Eur J Orthop Surg Traumatol + 9518037 + 1633-8065 + + IM + + Bicondylar tibial plateau fracture + Meniscus tear + Proximal fibula fracture + Tibial plateau fracture + +
+ + + + 2023 + 02 + 09 + + + 2023 + 02 + 26 + + + 2023 + 3 + 14 + 12 + 16 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917285 + 10.1007/s00590-023-03513-1 + 10.1007/s00590-023-03513-1 + + + + Agarwalla A, Puzzitiello R, Stone AV, Forsythe B (2018) Tibial tubercle avulsion fracture with multiple concomitant injuries in an adolescent male athlete. Case Rep Orthop 2018:1070628 + + 30174973 + 6098914 + + + + Barei DP, Nork SE, Bellabarba C, Sangeorzan BJ (2006) Is the absence of an ipsilateral fibular fracture predictive of increased radiographic tibial pilon fracture severity? J Orthop Trauma 20(1):6–10 + + 10.1097/01.bot.0000189589.94524.ff + 16424803 + + + + Berkson EM, Virkus WW (2006) High-energy tibial plateau fractures. J Am Acad Orthop Surg 14(1):20–31 + + 10.5435/00124635-200601000-00005 + 16394164 + + + + Borrelli J (2014) Management of soft tissue injuries associated with tibial plateau fractures. J Knee Surg 27(1):5–9 + + 24357043 + + + + Bozkurt M, Turanli S, Doral MN, Karaca S, Doğan M, Sesen H, Basbozkurt M (2005) The impact of proximal fibula fractures in the prognosis of tibial plateau fractures: a novel classification. Knee Surg Sports Traumatol Arthrosc 13(4):323–328 + + 10.1007/s00167-004-0525-5 + 15875164 + + + + Elsoe R, Larsen P, Nielsen NP, Swenne J, Rasmussen S, Ostgaard SE (2015) Population-based epidemiology of tibial plateau fractures. Orthopedics 38(9):e780-786 + + 10.3928/01477447-20150902-55 + 26375535 + + + + Gardner MJ, Yacoubian S, Geller D, Pode M, Mintz D, Helfet DL, Lorich DG (2006) Prediction of soft-tissue injuries in Schatzker II tibial plateau fractures based on measurements of plain radiographs. J Trauma 60(2):319–323 + + 10.1097/01.ta.0000203548.50829.92 + 16508489 + + + + Liu Y, Zhang Y, Liang X, Shao J, Ai Z, Yang T (2019) Relative incidence of proximal fibula fractures with tibial plateau fractures: an investigation of 354 cases. J Knee Surg. https://doi.org/10.1055/s-0039-1681045 + + 10.1055/s-0039-1681045 + 31470451 + + + + Luk PC, Charlton TP, Lee J, Thordarson DB (2013) Ipsilateral intact fibula as a predictor of tibial plafond fracture pattern and severity. Foot Ankle Int 34(10):1421–1426 + + 10.1177/1071100713491561 + 23720531 + + + + Molenaars RJ, Mellema JJ, Doornberg JN, Kloen P (2015) Tibial plateau fracture characteristics: computed tomography mapping of lateral, medial, and bicondylar fractures. J Bone Jt Surg Am 97(18):1512–1520 + + 10.2106/JBJS.N.00866 + + + + Mustonen AO, Koivikko MP, Lindahl J, Koskinen SK (2008) MRI of acute meniscal injury associated with tibial plateau fractures: prevalence, type, and location. AJR Am J Roentgenol 191(4):1002–1009 + + 10.2214/AJR.07.3811 + 18806134 + + + + Sillat T, Parkkinen M, Lindahl J, Mustonen A, Mäkinen TJ, Madanat R, Koskinen SK (2019) Fibular head avulsion fractures accompanying operative treated medial tibial plateau fractures. Skelet Radiol 48(9):1411–1416 + + 10.1007/s00256-019-03191-3 + + + + Stahl D, Serrano-Riera R, Collin K, Griffing R, Defenbaugh B, Sagi HC (2015) Operatively treated meniscal tears associated with tibial plateau fractures: a report on 661 patients. J Orthop Trauma 29(7):322–324 + + 10.1097/BOT.0000000000000290 + 25635356 + + + + Tan L, Li YH, Li Y, Lin T, Zhu D, Sun DH (2018) Tibial plateau fractures (AO type B3) combined with tibial tubercle fracture: case report and review of the literature. Medicine (Baltimore) 97(36):e12015 + + 10.1097/MD.0000000000012015 + 30200081 + + + + Tscherne H, Lobenhoffer P (1993) Tibial plateau fractures. Management and expected results. Clin Orthop Relat Res 292:87–100 + + 10.1097/00003086-199307000-00011 + + + + Zheng ZL, Yu YY, Chang HR, Liu H, Zhou HL, Zhang YZ (2019) Establishment of classification of tibial plateau fracture associated with proximal fibular fracture. Orthop Surg 11(1):97–101 + + 10.1111/os.12424 + 30734492 + 6430455 + + + + +
+ + + 36917287 + + 2023 + 03 + 14 + +
+ + 1438-1435 + + + 2023 + Mar + 14 + + + Emergency radiology + Emerg Radiol + + Artificial intelligence CAD tools in trauma imaging: a scoping review from the American Society of Emergency Radiology (ASER) AI/ML Expert Panel. + 10.1007/s10140-023-02120-1 + + AI/ML CAD tools can potentially improve outcomes in the high-stakes, high-volume model of trauma radiology. No prior scoping review has been undertaken to comprehensively assess tools in this subspecialty. + To map the evolution and current state of trauma radiology CAD tools along key dimensions of technology readiness. + Following a search of databases, abstract screening, and full-text document review, CAD tool maturity was charted using elements of data curation, performance validation, outcomes research, explainability, user acceptance, and funding patterns. Descriptive statistics were used to illustrate key trends. + A total of 4052 records were screened, and 233 full-text articles were selected for content analysis. Twenty-one papers described FDA-approved commercial tools, and 212 reported algorithm prototypes. Works ranged from foundational research to multi-reader multi-case trials with heterogeneous external data. Scalable convolutional neural network-based implementations increased steeply after 2016 and were used in all commercial products; however, options for explainability were narrow. Of FDA-approved tools, 9/10 performed detection tasks. Dataset sizes ranged from < 100 to > 500,000 patients, and commercialization coincided with public dataset availability. Cross-sectional torso datasets were uniformly small. Data curation methods with ground truth labeling by independent readers were uncommon. No papers assessed user acceptance, and no method included human-computer interaction. The USA and China had the highest research output and frequency of research funding. + Trauma imaging CAD tools are likely to improve patient care but are currently in an early stage of maturity, with few FDA-approved products for a limited number of uses. The scarcity of high-quality annotated data remains a major barrier. + © 2023. The Author(s), under exclusive licence to American Society of Emergency Radiology (ASER). + + + + Dreizin + David + D + http://orcid.org/0000-0002-0176-0912 + + Department of Diagnostic Radiology and Nuclear Medicine, R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, MD, USA. daviddreizin@gmail.com. + + + + Staziaki + Pedro V + PV + + Cardiothoracic Imaging, Department of Radiology, Larner College of Medicine, University of Vermont, Burlington, VT, USA. + + + + Khatri + Garvit D + GD + + Department of Radiology, University of Washington School of Medicine, Seattle, WA, USA. + + + + Beckmann + Nicholas M + NM + + Memorial Hermann Orthopedic & Spine Hospital, McGovern Medical School at UTHealth, Houston, TX, USA. + + + + Feng + Zhaoyong + Z + + Epidemiology & Public Health, University of Maryland School of Medicine, Baltimore, MD, USA. + + + + Liang + Yuanyuan + Y + + Epidemiology & Public Health, University of Maryland School of Medicine, Baltimore, MD, USA. + + + + Delproposto + Zachary S + ZS + + Division of Emergency Radiology, Department of Radiology, University of Michigan, Ann Arbor, MI, USA. + + + + Klug + Maximiliano + M + http://orcid.org/0000-0003-2844-5020 + + Sheba Medical Center, Ramat Gan, Israel. + + + + Spann + J Stephen + JS + + Department of Radiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA. + + + + Sarkar + Nathan + N + + University of Maryland School of Medicine, Baltimore, MD, USA. + + + + Fu + Yunting + Y + + Health Sciences and Human Services Library, University of Maryland, Baltimore, Baltimore, MD, USA. + + + + eng + + + NIH K08 EB027141-01A1 + National Institutes of Health (US) + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Emerg Radiol + 9431227 + 1070-3004 + + IM + + Artificial intelligence + Computer-aided detection + Emergency + Emergency radiology + Imaging + Machine learning + Radiology + Scoping review + Trauma + +
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+ + + 36917286 + + 2023 + 03 + 14 + +
+ + 1432-1068 + + + 2023 + Mar + 14 + + + European journal of orthopaedic surgery & traumatology : orthopedie traumatologie + Eur J Orthop Surg Traumatol + + The risk of infection in open distal tibial fracture: the DANGER score. + 10.1007/s00590-023-03517-x + + Open fractures of the distal tibia can be functionally devastating, and they remain one of the most challenging injuries treated by trauma surgeons usually burdened with a high rate of complications, including surgical site infections (SSI). Our aim is to analyze the most significant risk factors of SSI and propose a new scoring system-called the DANGER scale-potentially able to predict reliably and quantify the infection risk in distal tibia open fractures. + We identified six variables summarized in the acronym DANGER where D stands for Diabetes, A for Antibiotic, N for Nature of trauma (high- or low-energy trauma), G represents Grade of fracture following the AO/OTA classification, E indicates Exposure of the fracture according to the Gustilo-Anderson classification, and R represents Relative risk of patient, including use of tobacco, alcoholism, and psychiatric disorders. Therefore, total score ranged from 1 to 14, with a lower score indicating less risk to develop SSI. + A total of 103 patients with open distal tibial fractures were enrolled, 12 patients (11.6%) developed SSI. Regarding DANGER score, a rating of 8.2 was calculated in SSI group and 4.8 in non-SSI group. Based on Fisher's test, diabetes (odds = 31.8 p < 0.05), grade of articular involvement (p < 0.05), severity of open fracture (p < 0.05), and dangerous behavior such as use of tobacco, alcoholism, and psychiatric disorders (p < 0.05) were significantly correlated with infection. Significant difference between total DANGER scores in SSI and non-SSI groups was found (p < 0.001). ROC curve was calculated founding a potential threshold of 7.5 (p < 0.001). + Based on the above well-accepted risk factors, DANGER scale represents an advantageous and practical tool in order to readily estimate the risk of surgical site infection of open distal tibial fractures. + © 2023. The Author(s), under exclusive licence to Springer-Verlag France SAS, part of Springer Nature. + + + + Messori + Matteo + M + http://orcid.org/0000-0001-9679-851X + + Department of Orthopedics and Traumatology, San Carlo Borromeo Hospital, Milan, Italy. dr.matteo.messori@gmail.com. + + + University of Milan, 20122, Milan, Italy. dr.matteo.messori@gmail.com. + + + + Touloupakis + Georgios + G + + Department of Orthopedics and Traumatology, San Carlo Borromeo Hospital, Milan, Italy. + + + University of Milan, 20122, Milan, Italy. + + + + Gilli + Antonio + A + + Department of Orthopedics and Traumatology, San Carlo Borromeo Hospital, Milan, Italy. + + + University of Milan, 20122, Milan, Italy. + + + + Theodorakis + Emmanouil + E + + Department of Orthopedics and Traumatology, San Carlo Borromeo Hospital, Milan, Italy. + + + University of Milan, 20122, Milan, Italy. + + + + Pozzi + Pierrenzo + P + + Department of Orthopedics and Traumatology, San Carlo Borromeo Hospital, Milan, Italy. + + + University of Milan, 20122, Milan, Italy. + + + + Ghirardelli + Stefano + S + + Women's College Hospital, University Toronto Orthopedic Sports Medicine, 76 Grenville St, Toronto, ON, M5S 1B2, Canada. + + + + Antonini + Guido + G + + Department of Orthopedics and Traumatology, San Carlo Borromeo Hospital, Milan, Italy. + + + University of Milan, 20122, Milan, Italy. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + France + Eur J Orthop Surg Traumatol + 9518037 + 1633-8065 + + IM + + Infection + Lower limb + Scale + Trauma + +
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Diabetes Care 34(10):2211–2213. https://doi.org/10.2337/dc11-0846 + + 10.2337/dc11-0846 + 21816974 + 3177737 + + + + Yeramosu T, Satpathy J, Perdue PW, Toney CB, Torbert JT, Cinats DJ, Patel TT, Kates SL (2022) Risk factors for infection and subsequent adverse clinical results in the setting of operatively treated pilon fractures. J Orthop Trauma. https://doi.org/10.1097/BOT.0000000000002339 + + 10.1097/BOT.0000000000002339 + 34999622 + + + + Yokoyama K, Itoman M, Nakamura K, Uchino M (2007) New scoring system predicting the occurrence of deep infection in open tibial fractures: preliminary report. J Trauma Inj Infect Crit Care 63(1):108–112. https://doi.org/10.1097/TA.0b013e318074eacc + + 10.1097/TA.0b013e318074eacc + + + + +
+ + + 36917284 + + 2023 + 03 + 14 + +
+ + 2198-7793 + + 9 + 1 + + 2023 + Mar + 14 + + + Surgical case reports + Surg Case Rep + + COVID19 detection in appendix of acute appendicitis in a child: a case report and review of literature. + + 37 + + 10.1186/s40792-023-01618-7 + + Gastrointestinal symptoms are one of the most common presentations of Coronavirus disease-19 (COVID-19), even in children. Higher rates of complicated appendicitis have been demonstrated in the era of the COVID-19 outbreak, and it has been recently suggested that acute appendicitis may occur as a complication of COVID-19. However, the relationship between appendicitis and COVID-19 remains unclear. + A 7-year-old male presented to the pediatric emergency department with 2 days' history of lower abdominal discomfort and tenderness. On examination, his abdomen was distended with diffuse mild tenderness at the lower abdomen, which was aggravated by movement. He was also tested and was found to be positive for SARS-CoV-2. Computed tomography showed perforated appendicitis with a fecalith. The patient was admitted and laparoscopic appendectomy was successfully performed. Postoperatively, a minor intra-abdominal abscess was present, which successfully treated with antibiotics. Histopathology showed a markedly inflamed appendix with mucosal ulceration and transmural neutrophilic inflammation, which was consistent with phlegmonous appendicitis. Reverse transcription quantitative polymerase chain reaction using a surgically extracted appendix specimen revealed the presence of SARS-CoV-2 virus, which indicated a pathophysiological relationship between appendicitis and COVID-19. + The present case will provide further understanding of pediatric patients with concomitant COVID-19 and acute appendicitis. + © 2023. The Author(s). + + + + Kono + Jun + J + + Department of Pediatric Surgery, Reproductive and Developmental Medicine, Faculty of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan. + + + + Yoshimaru + Koichiro + K + + Department of Pediatric Surgery, Reproductive and Developmental Medicine, Faculty of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan. + + + + Matsuura + Toshiharu + T + http://orcid.org/0000-0002-4937-3890 + + Department of Pediatric Surgery, Reproductive and Developmental Medicine, Faculty of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan. matsuura.toshiharu.809@m.kyushu-u.ac.jp. + + + + Tamaki + Akihiko + A + + Department of Pediatric Surgery, Reproductive and Developmental Medicine, Faculty of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan. + + + Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan. + + + + Takemoto + Junkichi + J + + Department of Pediatric Surgery, Reproductive and Developmental Medicine, Faculty of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan. + + + Division of Pediatric Surgical Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-Ku, Tokyo, 104-0045, Japan. + + + + Matsumoto + Shinya + S + + Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan. + + + + Hotta + Taeko + T + + Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan. + + + + Kohashi + Kenichi + K + + Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan. + + + + Oda + Yoshinao + Y + + Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan. + + + + Tajiri + Tatsuro + T + + Department of Pediatric Surgery, Reproductive and Developmental Medicine, Faculty of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan. + + + + eng + + + 19K09098 + Japan Society for the Promotion of Science + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Surg Case Rep + 101662125 + 2198-7793 + + + Acute appendicitis + COVID-19 + Pediatrics + RT-qPCR + SARS-CoV-2 + +
+ + + + 2023 + 01 + 31 + + + 2023 + 03 + 08 + + + 2023 + 3 + 14 + 12 + 16 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917284 + 10.1186/s40792-023-01618-7 + 10.1186/s40792-023-01618-7 + + + + Chan JF-W, Yuan S, Kok K-H, To KK-W, Chu H, Yang J, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet. 2020;395:514–23. + + 10.1016/S0140-6736(20)30154-9 + 31986261 + 7159286 + + + + WHO Director-General’s opening remarks at the media briefing on COVID-19—11 March 2020. 2020. https://www.who.int/director-general/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19---11-march-2020 . Accessed 1 Nov 2022. + + + Pan L, Mu M, Yang P, Sun Y, Wang R, Yan J, et al. Clinical characteristics of COVID-19 patients with digestive symptoms in Hubei, China: a descriptive, cross-sectional, multicenter study. 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+ + + 36917289 + + 2023 + 03 + 14 + +
+ + 1437-2320 + + 46 + 1 + + 2023 + Mar + 14 + + + Neurosurgical review + Neurosurg Rev + + Microvascular decompression for young onset primary trigeminal neuralgia: a single-center experience. + + 69 + + 10.1007/s10143-023-01978-6 + + This study aims to explore the causes of primary young onset trigeminal neuralgia (TN) and the clinical outcomes of these patients. From May 2015 to December 2020, 19 primary TN patients with onset age under 30 years underwent microvascular decompression (MVD) in Nanjing Drum Tower Hospital. In this study, the clinical characteristics, surgical outcomes, and postoperative complications of these patients were analyzed retrospectively. Of the 19 patients, 5 were males and 14 were females, and the pain was located on the right side in 10 cases (52.6%). Vascular compression was observed in 17 patients, including 14 cases of superior cerebellar artery (SCA) alone, 2 cases of superior petrosal vein (SPV) alone, and 1 case of SCA and SPV combined. Two patients had no neurovascular conflict, and nerve combing was performed. After surgery, 18 patients got immediate pain relief; 1 patient improved but still had occasional pain. With a mean follow-up of 42.7 ± 22.3 months, one patient was found to have a relapse 45 months after MVD. Surgical complications including mild facial numbness in two patients and hearing impairment in one patient. Neurovascular compression is the main cause of young onset primary TN, and the most commonly encountered vascular was SCA. MVD is a safe and effective treatment for these patients. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Zhu + Chunran + C + + Department of Neurosurgery, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210009, Jiangsu, China. + + + Department of Neurosurgery, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210028, Jiangsu, China. + + + + Jiang + Chengrong + C + + Department of Neurosurgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, 210009, Jiangsu, China. + + + + Xu + Wu + W + + Department of Neurosurgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, 210009, Jiangsu, China. + + + + Wang + Jing + J + + Department of Neurosurgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, 210009, Jiangsu, China. + + + + Chong + Yulong + Y + + Department of Neurosurgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, 210009, Jiangsu, China. + + + + Liang + Weibang + W + + Department of Neurosurgery, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210009, Jiangsu, China. neurosurgery12c@163.com. + + + Department of Neurosurgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, 210009, Jiangsu, China. neurosurgery12c@163.com. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Neurosurg Rev + 7908181 + 0344-5607 + + IM + + Microvascular decompression + Neurovascular compression + Surgical outcomes + Trigeminal neuralgia + Young onset + +
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+ + + 36917294 + + 2023 + 03 + 14 + +
+ + 1432-198X + + + 2023 + Mar + 14 + + + Pediatric nephrology (Berlin, Germany) + Pediatr Nephrol + + Abnormal teeth and renal calcifications: Questions. + 10.1007/s00467-023-05904-2 + + + Therssen + Lore + L + http://orcid.org/0000-0002-3508-2427 + + Pediatrics, UZ Leuven, Katholieke Universiteit Leuven Universitaire Ziekenhuizen, Leuven, Belgium. Lore.therssen@uzleuven.be. + + + + Lambrecht + Loes + L + + Pediatrics, Pediatric Nephrology, AZ Herentals, Herentals, Belgium. + + + + Vansteenkiste + Griet + G + + Dentistry, Pediatric Dentistry, UZ Leuven, Leuven, Belgium. + + + + Knops + Noël + N + + Pediatrics, Groene Hart ziekenhuis, Gouda, Netherlands. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Pediatr Nephrol + 8708728 + 0931-041X + + IM + + Amelogenesis imperfecta + Child + Hypoplastic enamel + Nephrocalcinosis + +
+ + + + 2022 + 12 + 18 + + + 2023 + 02 + 01 + + + 2023 + 01 + 30 + + + 2023 + 3 + 14 + 12 + 16 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917294 + 10.1007/s00467-023-05904-2 + 10.1007/s00467-023-05904-2 + + +
+ + + 36917292 + + 2023 + 03 + 14 + +
+ + 1432-198X + + + 2023 + Mar + 14 + + + Pediatric nephrology (Berlin, Germany) + Pediatr Nephrol + + Abnormal teeth and renal calcifications: Answers. + 10.1007/s00467-023-05908-y + + + Therssen + Lore + L + + Pediatrics, UZ Leuven, Katholieke Universiteit Leuven Universitaire Ziekenhuizen, Leuven, Belgium. Lore.therssen@uzleuven.be. + + + + Lambrecht + Loes + L + + Pediatrics, Pediatric Nephrology, AZ Herentals, Herentals, Belgium. + + + + Vansteenkiste + Griet + G + + Dentistry, Pediatric Dentistry, UZ Leuven, Leuven, Belgium. + + + + Knops + Noël + N + + Pediatrics, Groene Hart Ziekenhuis, Gouda, Netherlands. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Pediatr Nephrol + 8708728 + 0931-041X + + IM + + Amelogenesis imperfecta + Enamel renal syndrome + FAM20A + Hypoplastic enamel + McGibbon syndrome + Nephrocalcinosis + +
+ + + + 2022 + 12 + 18 + + + 2023 + 02 + 01 + + + 2023 + 01 + 30 + + + 2023 + 3 + 14 + 12 + 16 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917292 + 10.1007/s00467-023-05908-y + 10.1007/s00467-023-05908-y + + + + Martelli-Júnior H, Ferreira SP, Pereira PCB, Coletta RD, de Aquino SN, Miranda DM (2012) Typical features of amelogenesis imperfecta in two patients with Bartter’s syndrome. Nephron Extra 2:319–325. https://doi.org/10.1159/000345801 + + 10.1159/000345801 + 23341834 + 3551389 + + + + Koruyucu M, Seymen F, Gencay G, Gencay K, Tuna EB, Shin TJ (2018) Nephrocalcinosis in amelogenesis imperfecta caused by the FAM20A mutation. Nephron Extra 139:189–196. https://doi.org/10.1159/000345801 + + 10.1159/000345801 + + + + Jaureguiberry G, de la Dure-Molla M, Parry D, Quentric M, Himmerkus N, Koike T (2012) Nephrocalcinosis (enamel renal syndrome) caused by autosomal recessive FAM20A Mutations. Nephron Physiol 122:1–6. https://doi.org/10.1159/000349989 + + 10.1159/000349989 + 23434854 + + + + Elizabeth V, Barbara S (2021) Oral health in children with chronic kidney disease. Pediatr Nephrol 36:3067–3075. https://doi.org/10.1007/s00467-020-04913-9 + + 10.1007/s00467-020-04913-9 + + + + Bjanid O, Adamczyk P, Stojewska M (2017) Rare case of nephrocalcinosis in a 14-year-old girl: Questions. Pediatr Nephrol 32:607–608. https://doi.org/10.1007/s00467-016-3434-1 + + 10.1007/s00467-016-3434-1 + 27384690 + + + + Vogel P, Hansen GM, Read RW (2013) Amelogenesis imperfecta and other biomineralization defects in Fam20a and Fam20c null mice. Vet Pathol 49:998–1017. https://doi.org/10.1177/0300985812453177 + + 10.1177/0300985812453177 + + + + Marra G, Taroni F, Berrettini A, Montanari E, Manzoni G, Montini G (2019) Pediatric nephrolithiasis: a systematic approach from diagnosis to treatment. J Nephrol 32:199–210. https://doi.org/10.1007/s40620-018-0487-1 + + 10.1007/s40620-018-0487-1 + 29680873 + + + + O’Sullivan J, Bitu CC, Daly SB, Urquhart JE, Barron MJ, Bhaskar SS, Martelli-Júnior H, dos Santos Neto PE, Mansilla MA, Murray JC, Coletta RD, Black GC, Dixon MJ (2011) Whole-Exome sequencing identifies FAM20A mutations as a cause of amelogenesis imperfecta and gingival hyperplasia syndrome. Am J Hum Genet 88:616–620. https://doi.org/10.1016/j.ajhg.2011.04.005 + + 10.1016/j.ajhg.2011.04.005 + 21549343 + 3146735 + + + + Xu R, Tan H, Zhang J, Yuan Z, Xie Q, Zhang L (2021) Fam20C in human diseases: emerging biological functions and therapeutic implications. Front Mol Biosci 8:790172. https://doi.org/10.3389/fmolb.2021.790172 + + 10.3389/fmolb.2021.790172 + 34988120 + 8721277 + + + + Wang SK, Aref P, Hu Y, Milkovich RN, Simmer JP (2013) FAM20A mutations can cause enamel-renal syndrome (ERS). PLoS Genet 9:e1003302. https://doi.org/10.1371/journal.pgen.1003302 + + 10.1371/journal.pgen.1003302 + 23468644 + 3585120 + + + + Kantaputra PN, Kaewgahya M, Khemaleelakul U, Dejkhamron P, Sutthimethakorn S, Thongboonkerd V, Iamaroon A (2013) Enamel-renal-gingival syndrome and FAM20A mutations. Am J Med Genet Part A 164A:1–9. https://doi.org/10.1002/ajmg.a.36187 + + 10.1002/ajmg.a.36187 + 24259279 + + + + de la Dure-Molla M, Quentric M, Yamaguti PM (2014) Pathognomonic oral profile of enamel renal syndrome (ERS) caused by recessive FAM20A mutations. Orphanet J Rare Dis 9:84. https://doi.org/10.1186/1750-1172-9-84 + + 10.1186/1750-1172-9-84 + 24927635 + 4071802 + + + + Wang SK, Reid BM, Dugan SL, Roggenbuck JA, Read L, Aref P, Taheri AP, Yeganeh MZ, Simmer JP, Hu JC (2014) FAM20A mutations associated with enamel renal syndrome. J Dent Res 93:42–48. https://doi.org/10.1177/0022034513512653 + + 10.1177/0022034513512653 + 24196488 + 3865794 + + + + Farias MLM, Ornela GO, de Andrade RS, Martelli DRB, Dias VO, Júnior HM (2021) Enamel renal syndrome: a systematic review. Indian J Nephrol 31:1–8. https://doi.org/10.4103/ijn.IJN_27_19 + + 10.4103/ijn.IJN_27_19 + 33994680 + 8101666 + + + + Hunter L, Addy LD, Knox J, Drage N (2007) Is amelogenesis imperfecta an indication for renal examination? Int J Paediatr Dent 17:62–65. https://doi.org/10.1111/j.1365-263X.2006.00782.x + + 10.1111/j.1365-263X.2006.00782.x + 17181581 + + + + Nitayavardhana I, Theerapanon T, Srichomthong C, Piwluang S, Wichadakul D, Porntaveetus T, Shotelersuk V (2020) Four novel mutations of FAM20A in amelogenesis imperfecta type IG and review of literature for its genotype and phenotype spectra. Mol Genet Genomics 295:923–931. https://doi.org/10.1007/s00438-020-01668-8 + + 10.1007/s00438-020-01668-8 + 32246227 + + + + Martelli-Júnior H, dos Santos Neto PE, de Aquino SN, de Oliveira Santos CC, Borges SP, Oliveira EA, Lopes MA, Coletta RD (2011) Amelogenesis imperfecta and nephrocalcinosis syndrome: a case report and review of the literature. Nephron Physiol 118:62–65. https://doi.org/10.1159/000322828 + + 10.1159/000322828 + + + + Reddy P, Aravelli S, Goud S, Malathi L (2019) Amelogenesis imperfecta with nephrocalcinosis: a rare association in siblings. Cureus 11:e5060. https://doi.org/10.7759/cureus.5060 + + 10.7759/cureus.5060 + 31516772 + 6721873 + + + + Kantaputra PN, Bongkochwilawan C, Lubinsky M, Pata S, Kaewgahya M, Tong HJ (2017) Periodontal disease and FAM20A mutations. J Hum Genet 62:679–686. https://doi.org/10.1038/jhg.2017.26 + + 10.1038/jhg.2017.26 + 28298625 + + + + Manoj V, Sandeepa NC, Selvamani M, Panjami M (2019) Association of enamel-renal syndrome with sialolith: a rare entity. J Oral Maxillofac Pathol 23:126–129. https://doi.org/10.4103/jomfp.JOMFP_9_18 + + 10.4103/jomfp.JOMFP_9_18 + 30967741 + 6421903 + + + + Normand de la Tranchade I, Bonarek H, Marteau JM, Boileau MJ, Nancy J (2003) Amelogenesis imperfecta and nephrocalcinosis: a new case of this rare syndrome. J Clin Pediatr Dent 27:171–175. https://doi.org/10.17796/jcpd.27.2.3188100w6t4516j8 + + 10.17796/jcpd.27.2.3188100w6t4516j8 + 12597691 + + + + Laouina S, Bloch Zupan A, El Alloussi M (2017) Enamel-renal syndrome with congenital heart defects and asthma: a rare association in a Moroccan child. Clin Dysmorphol 26:114–116. https://doi.org/10.1097/MCD.0000000000000146 + + 10.1097/MCD.0000000000000146 + 27541981 + + + + Wang YP, Lin HY, Zhong WL, Simmer JP, Wang SK (2019) Transcriptome analysis of gingival tissues of enamel-renal syndrome. J Periodontal Res 54:653–661. https://doi.org/10.1111/jre.12666 + + 10.1111/jre.12666 + 31131889 + 6848751 + + + + Ravi P, Ekambaranath TS, EllilArasi S, Fernando E (2013) Distal renal tubular acidosis and amelogenesis imperfecta: a rare association. Indian J Nephrol 23:452–455. https://doi.org/10.4103/0971-4065.120345 + + 10.4103/0971-4065.120345 + 24339526 + 3841516 + + + + Kirzioglu Z, Ulu KG, Sezer MT, Yüksel S (2009) The relationship of amelogenesis imperfecta and nephrocalcinosis syndrome. Med Oral Patol Oral Cir Bucal 14:e579-582. https://doi.org/10.4317/medoral.14.e579 + + 10.4317/medoral.14.e579 + 19680205 + + + + Kala Vani SV, Varsha M, Sankar YU (2012) Enamel renal syndrome: a rare case report. 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+ + + 36917293 + + 2023 + 03 + 14 + +
+ + 1432-198X + + + 2023 + Mar + 14 + + + Pediatric nephrology (Berlin, Germany) + Pediatr Nephrol + + Primary hyperoxaluria type 1 in children: clinical and laboratory manifestations and outcome. + 10.1007/s00467-023-05917-x + + Primary hyperoxaluria (PH) results from genetic mutations in different genes of glyoxylate metabolism, which cause significant increases in production of oxalate by the liver. This study aimed to report clinical and laboratory manifestations and outcome of PH type 1 in children in our center. + A single-center observational cohort study was conducted at Children's University Hospital in Damascus, and included all patients admitted from 2018 to 2020, with a diagnosis of hyperoxaluria (urinary oxalate excretion > 45 mg/1.73 m2/day, or > 0.5 mmol/1.73 m2/day). PH type 1 (PH1) diagnosis was established by identification of biallelic pathogenic variants (compound heterozygous or homozygous mutations) in AGXT gene on molecular genetic testing. + The study included 100 patients with hyperoxaluria, with slight male dominance (57%), and median age 1.75 years (range, 1 month-14 years). Initial complaint was urolithiasis or nephrocalcinosis in 47%, kidney failure manifestations in 29%, and recurrent urinary tract infection in 24%. AGXT mutations were detected in 40 patients, and 72.5% of PH1 patients had kidney failure at presentation. Neither gender, age nor urinary oxalate excretion in 24 h had statistical significance in distinguishing PH1 from other forms of hyperoxaluria (P-Value > 0.05). Parental consanguinity, family history of kidney stones, bilateral nephrocalcinosis, presence of oxalate crystals in random urine sample, kidney failure and mortality were statistically significantly higher in PH1 (P-values < 0.05). Mortality was 32.5% among PH1 patients, with 4 PH1 patients (10%) on hemodialysis awaiting combined liver-kidney transplantation. + PH1 is still a grave disease with wide variety of clinical presentations which frequent results in delays in diagnosis, thus kidney failure is still a common presentation. In Syria, we face many challenges in diagnosis of PH, especially PH2 and PH3, and in management, with hopes that diagnosis tools and modern therapies will become available in our country. Graphical abstract A higher resolution version of the Graphical abstract is available as Supplementary information. + © 2023. The Author(s), under exclusive licence to International Pediatric Nephrology Association. + + + + Wannous + Hala + H + http://orcid.org/0000-0003-0585-1157 + + Faculty Member of Pediatric Nephrology in Faculty of Medicine, Damascus University, Damascus, Syria. hala.wannous@damascusuniversity.edu.sy. + + + Pediatric Nephrology, Hemodialysis, and Kidney Transplantation Department at Children's University Hospital, Damascus University, Damascus, Syria. hala.wannous@damascusuniversity.edu.sy. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Pediatr Nephrol + 8708728 + 0931-041X + + IM + + Children's hospital + Kidney stones + Nephrocalcinosis + Primary hyperoxaluria + +
+ + + + 2022 + 12 + 06 + + + 2023 + 02 + 02 + + + 2023 + 02 + 01 + + + 2023 + 3 + 14 + 12 + 16 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917293 + 10.1007/s00467-023-05917-x + 10.1007/s00467-023-05917-x + + + + Alon US, Srivastava T (2017) Urolithiasis in children. In: Kher KK, Schnaper HW, Greenbaum LA (eds) Clinical Pediatric Nephrology, 3rd edn. Boca Raton, pp 1014–1015 + + + Demoulin N, Aydin S, Gillion V, Morelle J, Jadoul M (2022) Pathophysiology and management of hyperoxaluria and oxalate nephropathy: a review. Am J Kidney Dis 79:717–727. https://doi.org/10.1053/j.ajkd.2021.07.018 + + 10.1053/j.ajkd.2021.07.018 + 34508834 + + + + Danpure CJ (2006) Primary hyperoxaluria type 1: AGT mistargeting highlights the fundamental differences between the peroxisomal and mitochondrial protein import pathways. Biochim Biophys Acta 1763:1776–1784 + + 10.1016/j.bbamcr.2006.08.021 + 17027096 + + + + Harambat J, Fargue S, Bacchetta J, Acquaviva C, Cochat P (2011) Primary hyperoxaluria. Int J Nephrol 2011:864580. https://doi.org/10.4061/2011/864580 + + 10.4061/2011/864580 + + + + Milliner DS, Harris PC, Sas DJ, Cogal AG, Lieske JC (2002) Primary Hyperoxaluria Type 1. In: Adam MP, Everman DB, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A (eds). GeneReviews® [Internet]. University of Washington, Seattle, Seattle, 1993–2022 + + + Weigert A, Martin-Higueras C, Hoppe B (2018) Novel therapeutic approaches in primary hyperoxaluria. 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Nat Rev Nephrol 8:467–475. https://doi.org/10.1038/nrneph.2012.113 + + 10.1038/nrneph.2012.113 + 22688746 + + + + Hoppe B, Martin-Higueras C (2022) Improving Treatment Options for Primary Hyperoxaluria. Drugs 82:1077–1094. https://doi.org/10.1007/s40265-022-01735-x + + 10.1007/s40265-022-01735-x + 35779234 + 9329168 + + + + Cochat P, Rumsby G (2013) Primary hyperoxaluria. N Engl J Med 369:649–658. https://doi.org/10.1056/NEJMra1301564 + + 10.1056/NEJMra1301564 + 23944302 + + + + Beck BB, Hoyer-Kuhn H, Göbel H, Habbig S, Hoppe B (2013) Hyperoxaluria and systemic oxalosis: an update on current therapy and future directions. Expert Opin Investig Drugs 22:117–129. https://doi.org/10.1517/13543784.2013.741587 + + 10.1517/13543784.2013.741587 + 23167815 + + + + Devresse A, Cochat P, Godefroid N, Kanaan N (2020) Transplantation for primary hyperoxaluria type 1: designing new strategies in the era of promising therapeutic perspectives. Kidney Int Rep 5:2136–2145. https://doi.org/10.1016/j.ekir.2020.09.022 + + 10.1016/j.ekir.2020.09.022 + 33305106 + 7710835 + + + + Metry EL, Garrelfs SF, Peters-Sengers H, Hulton SA, Acquaviva C, Bacchetta J, Beck BB, Collard L, Deschênes G, Franssen C, Kemper MJ, Lipkin GW, Mandrile G, Mohebbi N, Moochhala SH, Oosterveld MJS, Prikhodina L, Hoppe B, Cochat P, Groothoff JW, OxalEurope Consortium (2021) Long-term transplantation outcomes in patients with primary hyperoxaluria type 1 included in the European Hyperoxaluria Consortium (OxalEurope) registry. Kidney Int Rep 7:210–220. https://doi.org/10.1016/j.ekir.2021.11.006 + + 10.1016/j.ekir.2021.11.006 + 35155860 + 8821040 + + + + Garrelfs SF, Frishberg Y, Hulton SA, Koren MJ, O’Riordan WD, Cochat P, Deschênes G, Shasha-Lavsky H, Saland JM, van’t Hoff WG, Fuster DG, Magen D, Moochhala SH, Schalk G, Simkova E, Groothoff JW, Sas DJ, Meliambro KA, Lu J, Sweetser MT, Garg PP, Vaishnaw AK, Gansner JM, McGregor TL, Lieske JC; ILLUMINATE-A Collaborators (2021) Lumasiran, an RNAi therapeutic for primary hyperoxaluria type 1. N Engl J Med 384:1216–1226. https://doi.org/10.1056/NEJMoa2021712 + + 10.1056/NEJMoa2021712 + 33789010 + + + + Hoppe B, Koch A, Cochat P, Garrelfs SF, Baum MA, Groothoff JW, Lipkin G, Coenen M, Schalk G, Amrite A, McDougall D, Barrios K, Langman CB (2022) Safety, pharmacodynamics, and exposure-response modeling results from a first-in-human phase 1 study of nedosiran (PHYOX1) in primary hyperoxaluria. 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Am J Transplant 10:2493–2501. https://doi.org/10.1111/j.1600-6143.2010.03271.x + + 10.1111/j.1600-6143.2010.03271.x + 20849551 + 2965313 + + + + Bunchman TE, Swartz RD (1994) Oxalate removal in type I hyperoxaluria or acquired oxalosis using HD and equilibration PD. Perit Dial Int 14:81–84 + + 10.1177/089686089401400117 + 8312423 + + + + Illies F, Bonzel KE, Wingen AM, Latta K, Hoyer PF (2006) Clearance and removal of oxalate in children on intensified dialysis for primary hyperoxaluria type 1. Kidney Int 70:1642–1648. https://doi.org/10.1038/sj.ki.5001806 + + 10.1038/sj.ki.5001806 + 16955107 + + + + Hoppe B, Graf D, Offner G, Latta K, Byrd DJ, Michalk D, Brodehl J (1996) Oxalate elimination via hemodialysis or peritoneal dialysis in children with chronic renal failure. Pediatr Nephrol 10:488–492. https://doi.org/10.1007/s004670050145 + + 10.1007/s004670050145 + 8865249 + + + + +
+ + + 36917288 + + 2023 + 03 + 14 + +
+ + 1438-1435 + + + 2023 + Mar + 14 + + + Emergency radiology + Emerg Radiol + + Point-of-care ultrasound: impact on emergency department length of stay for suspected lower extremity DVT. + 10.1007/s10140-023-02123-y + + Point-of-care ultrasound (POCUS) has demonstrated excellent sensitivity and specificity for the diagnosis of DVT in the emergency department (ED). Before POCUS became widespread, patients underwent radiology department comprehensive lower extremity venous duplex ultrasounds (RADUS) which may be associated with a prolonged length of stay. + The goal of this study is to evaluate the impact of POCUS on ED arrival to disposition (ATD) time for patients presenting to the ED with suspected lower extremity DVT. + This is a retrospective chart analysis of ED visits to an urban, university-affiliated community hospital from January 2019 to December 2020. This study compared ATD between patients who underwent POCUS by an emergency medicine physician and RADUS by the radiology department. + In total, 1204 patients underwent POCUS, and 1582 patients were evaluated with RADUS. The POCUS mean ATD was 313 ± 16.8 min compared to the RADUS arm average of 323 ± 57.9 min (p = 0.56). Order to disposition time (OTD) was prolonged among the RADUS group relative to POCUS. ATD was significantly reduced in the POCUS subgroup of patients presenting during night shift when RADUS was not available, 326 ± 28.2 min versus 630 ± 109 min (p < 0.05). + ED POCUS scans decrease the amount of time between order placement and disposition when compared to RADUS. POCUS significantly decreases length of stay in the ED when RADUS is not available. + © 2023. The Author(s), under exclusive licence to American Society of Emergency Radiology (ASER). + + + + Estrella + Yonathan + Y + http://orcid.org/0000-0001-8862-9126 + + Department of Emergency Medicine, New York Presbyterian Brooklyn Methodist Hospital, Brooklyn, NY, USA. yoe9014@nyp.org. + + + + Bronzo + Alexander + A + + Department of Emergency Medicine, New York Presbyterian Brooklyn Methodist Hospital, Brooklyn, NY, USA. + + + + Fey + Luke + L + + Department of Emergency Medicine, University of Miami, Miami, FL, USA. + + + + Ryoo + Aaron + A + + Department of Emergency Medicine, Maimonides Medical Center, Brooklyn, NY, USA. + + + + Ayala + Samuel + S + + Department of Emergency Medicine, New York Presbyterian Brooklyn Methodist Hospital, Brooklyn, NY, USA. + + + + Lin + Maya + M + + Department of Emergency Medicine, New York Presbyterian Brooklyn Methodist Hospital, Brooklyn, NY, USA. + + + + Gaeta + Theodore + T + + Department of Emergency Medicine, New York Presbyterian Brooklyn Methodist Hospital, Brooklyn, NY, USA. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Emerg Radiol + 9431227 + 1070-3004 + + IM + + Deep vein thrombosis + Lower extremity compression + POCUS + +
+ + + + 2023 + 01 + 27 + + + 2023 + 03 + 07 + + + 2023 + 3 + 14 + 12 + 16 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917288 + 10.1007/s10140-023-02123-y + 10.1007/s10140-023-02123-y + + + + Seyedhosseini J, Fadavi A, Vahidi E, Saeedi M, Momeni M (2017) Impact of point-of-care ultrasound on disposition time of patients presenting with lower extremity deep vein thrombosis, done by emergency physicians. Turk J Emerg Med 18(1):20–24. https://doi.org/10.1016/j.tjem.2017.12.003 + + 10.1016/j.tjem.2017.12.003 + 29942878 + 6009805 + + + + Bĕlohlávek J, Dytrych V, Linhart A (2013) Pulmonary embolism, part I: Epidemiology, risk factors and risk stratification, pathophysiology, clinical presentation, diagnosis and nonthrombotic pulmonary embolism. Exp Clin Cardiol 18(2):129–138 + + 23940438 + 3718593 + + + + Lee JS, Moon T, Kim TH, Kim SY, Choi JY, Lee KB, Kwon YJ, Song SH, Kim SH, Kim HO, Hwang HK, Kim MJ, Lee YK (2016) Deep vein thrombosis in patients with pulmonary embolism: prevalence, clinical significance and outcome. Vasc Specialist Int 32(4):166–174. https://doi.org/10.5758/vsi.2016.32.4.166 + + 10.5758/vsi.2016.32.4.166 + 28042556 + 5198763 + + + + Singer AJ, Thode HC Jr, Peacock WF 4th (2016) Admission rates for emergency department patients with venous thromboembolism and estimation of the proportion of low risk pulmonary embolism patients: a US perspective. Clin Exp Emerg Med 3(3):126–131. Published 2016 Sep 30. https://doi.org/10.15441/ceem.15.096 + + + Bulger CM, Jacobs C, Patel NH (2004) Epidemiology of acute deep vein thrombosis. Tech Vasc Interv Radiol 7(2):50–54. https://doi.org/10.1053/j.tvir.2004.02.001 + + 10.1053/j.tvir.2004.02.001 + 15252760 + + + + Spyropoulos AC, Lin J (2007) Direct medical costs of venous thromboembolism and subsequent hospital readmission rates: an administrative claims analysis from 30 managed care organizations. J Manag Care Pharm 13(6):475–486. https://doi.org/10.18553/jmcp.2007.13.6.475 + + 10.18553/jmcp.2007.13.6.475 + 17672809 + + + + Beam DM, Kahler ZP, Kline JA (2015) Immediate discharge and home treatment with rivaroxaban of low-risk venous thromboembolism diagnosed in two U.S. emergency departments: a one-year preplanned analysis. Acad Emerg Med 22(7):788–795. https://doi.org/10.1111/acem.12711 + + + Torres-Macho J, Antón-Santos JM, García-Gutierrez I, de Castro-García M, Gámez-Díez S, de la Torre PG, Latorre-Barcenilla G, Majo-Carbajo Y, Reparaz-González JC, de Casasola GG; Working Group of Clinical Ultrasound, Spanish Society of Internal Medicine (2012) Initial accuracy of bedside ultrasound performed by emergency physicians for multiple indications after a short training period. Am J Emerg Med 0(9):1943–9. https://doi.org/10.1016/j.ajem.2012.04.015 . + + + Canakci ME, Acar N, Bilgin M, Kuas C (2020) Diagnostic value of point-of-care ultrasound in deep vein thrombosis in the emergency department. J Clin Ultrasound 48(9):527–531. https://doi.org/10.1002/jcu.22892 + + 10.1002/jcu.22892 + 32643227 + + + + Crisp JG, Lovato LM, Jang TB (2010) Compression ultrasonography of the lower extremity with portable vascular ultrasonography can accurately detect deep venous thrombosis in the emergency department. Ann Emerg Med 56(6):601–610. https://doi.org/10.1016/j.annemergmed.2010.07.010 + + 10.1016/j.annemergmed.2010.07.010 + 20864215 + + + + Pedraza García J, Valle Alonso J, Ceballos García P, Rico Rodríguez F, Aguayo López MÁ, Muñoz-Villanueva MDC (2018) Comparison of the accuracy of emergency department-performed point-of-care ultrasound (POCUS) in the diagnosis of lower extremity deep vein thrombosis. J Emerg Med 54(5):656–664. https://doi.org/10.1016/j.jemermed.2017.12.020 + + 10.1016/j.jemermed.2017.12.020 + 29306580 + + + + Elsenga HE, Collée A, Rosendaal AV (2021) Agreement between emergency physicians and radiologists for the diagnosis of deep venous thrombosis with compression ultrasound: a prospective study. Eur J Emerg Med 28(1):25–28. https://doi.org/10.1097/MEJ.0000000000000728 + + 10.1097/MEJ.0000000000000728 + 32657823 + + + + Theodoro D, Blaivas M, Duggal S, Snyder G, Lucas M (2004) Real-time B-mode ultrasound in the ED saves time in the diagnosis of deep vein thrombosis (DVT). Am J Emerg Med 22(3):197–200. https://doi.org/10.1016/j.ajem.2004.02.007 + + 10.1016/j.ajem.2004.02.007 + 15138956 + + + + +
+ + + 36917291 + + 2023 + 03 + 14 + +
+ + 1432-1076 + + + 2023 + Mar + 14 + + + European journal of pediatrics + Eur J Pediatr + + Trends in hospital admissions among children with asthma in Spain (2011-2020). + 10.1007/s00431-023-04873-w + + The purpose of this study is to describe and assess changes in incidence, clinical conditions, use of mechanical ventilation, length of hospital stay (LOHS), and in-hospital mortality (IHM) among children hospitalized with asthma in Spain from 2011 to 2020. We analyzed children aged 0 to 15 years hospitalized with an ICD code for asthma included in the Spanish National Hospital Discharge Database (SNHDD). The analysis was conducted for asthma as the primary diagnosis and with asthma in any diagnosis position. Joinpoint regression was used to assess time trends in incidence. We included a total of 85,664 children hospitalized with asthma; of these, 46,727 (54.55%) had asthma coded as the primary diagnosis. The number of boys was higher than the number of girls, irrespective of age group or diagnostic position. The frequency of asthma as primary diagnosis decreased from 55.7% in 2011 to 43.96% in 2020 (p < 0.001). The incidence of hospitalizations because of asthma decreased significantly from 2011 to 2020, with a faster decrease from 2018 onwards. Over time, the proportion of older children increased. In the year 2020, only 55 children had codes for asthma and COVID-19 in their discharge report, and this infection had no effect on hospitalizations this year. A significant increase in the use of non-invasive ventilation (NIV) was observed over time. Irrespective of the diagnostic position, LOHS and IHM remained stable over time, with the IHM under 0.1%.  Conclusion: Our results show a decrease in the incidence of hospital admissions with asthma either as the primary diagnosis or in any position. The age of children hospitalized seems to be increasing as the use of NIV. Better management of the disease from primary care and the emergency department as is the use of NIV could explain the reduction in incidence. What is Known: • Asthma is the most common chronic respiratory in childhood in high income countries. • The incidence of hospital admissions with asthma and associated factors is one of the best sources of information on morbidity trends and prognosis. What is New: • The incidence of hospital admissions for asthma in Spain decreased in children between 2011 and 2020 with a more frequent use of non-invasive mechanical ventilation and low mortality rates. • COVID-19 did not cause an increase in admissions with asthma in the year 2020. + © 2023. The Author(s). + + + + Gutierrez-Albaladejo + Natalia + N + + Allergy Department, Hospital Universitario Fundación de Alcorcón, 28922 Alcorcón, Madrid, Spain. + + + + Jimenez-Garcia + Rodrigo + R + http://orcid.org/0000-0001-5906-9393 + + Department of Public Health & Maternal and Child Health, Faculty of Medicine, Universidad Complutense de Madrid, 28040, Madrid, Spain. rodrijim@ucm.es. + + + + Albaladejo-Vicente + Romana + R + + Department of Public Health & Maternal and Child Health, Faculty of Medicine, Universidad Complutense de Madrid, 28040, Madrid, Spain. + + + + Villanueva-Orbaiz + Rosa + R + + Department of Public Health & Maternal and Child Health, Faculty of Medicine, Universidad Complutense de Madrid, 28040, Madrid, Spain. + + + + de-Miguel-Diez + Javier + J + + Respiratory Department, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Faculty of Medicine, Universidad Complutense de Madrid, 28040, Madrid, Spain. + + + + Noriega + Concepción + C + + Department of Nursery and Physiotherapy, Faculty of Medicine and Health Sciences, University of Alcalá, 28871, Alcalá de Henares, Madrid, Spain. + + + + Lopez-de-Andres + Ana + A + http://orcid.org/0000-0001-5551-5181 + + Department of Public Health & Maternal and Child Health, Faculty of Medicine, Universidad Complutense de Madrid, 28040, Madrid, Spain. + + + + eng + + + 970970 + Universidad Complutense de Madrid + + + + 970970 + Universidad Complutense de Madrid + + + + 970970 + Universidad Complutense de Madrid + + + + 970970 + Universidad Complutense de Madrid + + + + 970970 + Universidad Complutense de Madrid + + + + INV.AY.20.2021.1E126 + Comunidad de Madrid + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Eur J Pediatr + 7603873 + 0340-6199 + + IM + + Asthma + COVID-19 + Exacerbations + Hospitalization + Incidence + Mortality + Pediatric + +
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Epub 2009 Feb 22 PMID: 19237391 + + 10.1136/thx.2008.106609 + + + + Anandan C, Nurmatov U, van Schayck OC, Sheikh A (2010) Is the prevalence of asthma declining? Systematic review of epidemiological studies. Allergy 65:152.  https://doi.org/10.1111/j.1398-9995.2009.02244.x + + 10.1111/j.1398-9995.2009.02244.x + 19912154 + + + + Akinbami LJ, Simon AE, Rossen LM (2016) Changing trends in asthma prevalence among children. Pediatrics 137.  https://doi.org/10.1542/peds.2015-2354 + + + Zahran HS, Bailey CM, Damon SA, Garbe PL, Breysse PN (2018) Vital signs: asthma in children - United States, 2001–2016. MMWR Morb Mortal Wkly Rep 67:149–155. https://doi.org/10.15585/mmwr.mm6705e1 + + 10.15585/mmwr.mm6705e1 + 29420459 + 5812476 + + + + Mallol J, Crane J, von Mutius E, Odhiambo J, Keil U, Stewart A; ISAAC Phase Three Study Group (2013) The International Study of Asthma and Allergies in Childhood (ISAAC) phase three: a global synthesis. 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+ + 1432-8798 + + 168 + 4 + + 2023 + Mar + 14 + + + Archives of virology + Arch Virol + + Recombinant characteristics of three novel HIV-1 second-generation recombinant forms composed of CRF01_AE and CRF07_BC isolated in Hebei province, China. + + 111 + + 10.1007/s00705-023-05738-1 + + Human immunodeficiency virus 1 (HIV-1) is a fast-evolving, genetically diverse virus. The HIV-1 evolution rate is also significantly influenced by the frequency of HIV-1 spread in a population. Transmission via homosexual contact has become the predominant transmission route, leading to an increase in the HIV-1 epidemic in Hebei province, China. In this study, we report three novel HIV-1 CRF01_AE/CRF07_BC recombinant forms isolated from three men who have sex with men (MSM) in the cities of Shijiazhuang (20747) and Langfang (20809 and 20820). Phylogenetic analysis based on HIV-1 near-full-length genome (NFLG) sequences indicated that the three novel recombinant forms formed a distinct monophyletic branch that was separate from all known HIV-1 subtypes and circulating recombinant forms (CRFs). Breakpoint analysis showed that the three NFLGs displayed different recombinant patterns. NFLGs 20747 and 20809 had a recombinant pattern with subtype CRF01_AE gene fragments inserted into a CRF07_BC backbone, spanning from the gag to env gene regions, whereas NFLG 20820 had a recombinant pattern with subtype CRF07_BC gene fragments inserted into a CRF01_AE backbone. Subregion phylogenetic analysis confirmed that these three NFLGs comprised CRF01_AE and CRF07_BC. Our findings confirm the emergence of novel recombinant forms and highlight the need for continuous monitoring of the diversity of HIV-1 among sexually active populations, especially MSM, to better control the HIV-1 epidemic. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature. + + + + Lu + Xinli + X + http://orcid.org/0000-0003-4613-2028 + + Department of AIDS Research, Hebei Key Laboratory of Pathogen and Epidemiology of Infectious Disease, Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang, 050021, Hebei, China. + + + College of Public Health, Hebei Medical University, Shijiazhuang, 050017, Hebei, China. + + + College of Public Health, North China University of Science and Technology, Tangshan, 063210, Hebei, China. + + + + Zhang + Xinyu + X + + College of Public Health, Hebei Medical University, Shijiazhuang, 050017, Hebei, China. + + + + An + Ning + N + + Department of AIDS Research, Hebei Key Laboratory of Pathogen and Epidemiology of Infectious Disease, Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang, 050021, Hebei, China. + + + + Tang + Xiangyun + X + + College of Public Health, North China University of Science and Technology, Tangshan, 063210, Hebei, China. + + + + Wang + Yingying + Y + + Department of AIDS Research, Hebei Key Laboratory of Pathogen and Epidemiology of Infectious Disease, Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang, 050021, Hebei, China. + + + + Liu + Meng + M + + Department of AIDS Research, Hebei Key Laboratory of Pathogen and Epidemiology of Infectious Disease, Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang, 050021, Hebei, China. + + + + Yan + Li + L + + Department of AIDS Research, Hebei Key Laboratory of Pathogen and Epidemiology of Infectious Disease, Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang, 050021, Hebei, China. + + + + Zhang + Yuqi + Y + + Department of AIDS Research, Hebei Key Laboratory of Pathogen and Epidemiology of Infectious Disease, Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang, 050021, Hebei, China. + + + + Li + Qi + Q + + Department of AIDS Research, Hebei Key Laboratory of Pathogen and Epidemiology of Infectious Disease, Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang, 050021, Hebei, China. liqi_3358@163.com. + + + Hebei Key Laboratory of Pathogen and Epidemiology of Infectious Disease, Hebei Provincial Center for Disease Control and Prevention, No. 97 Huai'an East Road, Yuhua Distinct, Shijiazhuang, 050021, Hebei, China. liqi_3358@163.com. + + + + eng + + + 192777107D + the Key Science and Technology Planning Project of Hebei province + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + Austria + Arch Virol + 7506870 + 0304-8608 + + IM + + CRF01_AE + CRF07_BC + HIV-1 + Hebei + MSM + +
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+ + + 36917283 + + 2023 + 03 + 14 + +
+ + 1432-184X + + + 2023 + Mar + 14 + + + Microbial ecology + Microb Ecol + + Current Scenario and Future Prospects of Endophytic Microbes: Promising Candidates for Abiotic and Biotic Stress Management for Agricultural and Environmental Sustainability. + 10.1007/s00248-023-02190-1 + + Globally, substantial research into endophytic microbes is being conducted to increase agricultural and environmental sustainability. Endophytic microbes such as bacteria, actinomycetes, and fungi inhabit ubiquitously within the tissues of all plant species without causing any harm or disease. Endophytes form symbiotic relationships with diverse plant species and can regulate numerous host functions, including resistance to abiotic and biotic stresses, growth and development, and stimulating immune systems. Moreover, plant endophytes play a dominant role in nutrient cycling, biodegradation, and bioremediation, and are widely used in many industries. Endophytes have a stronger predisposition for enhancing mineral and metal solubility by cells through the secretion of organic acids with low molecular weight and metal-specific ligands (such as siderophores) that alter soil pH and boost binding activity. Finally, endophytes synthesize various bioactive compounds with high competence that are promising candidates for new drugs, antibiotics, and medicines. Bioprospecting of endophytic novel secondary metabolites has given momentum to sustainable agriculture for combating environmental stresses. Biotechnological interventions with the aid of endophytes played a pivotal role in crop improvement to mitigate biotic and abiotic stress conditions like drought, salinity, xenobiotic compounds, and heavy metals. Identification of putative genes from endophytes conferring resistance and tolerance to crop diseases, apart from those involved in the accumulation and degradation of contaminants, could open new avenues in agricultural research and development. Furthermore, a detailed molecular and biochemical understanding of endophyte entry and colonization strategy in the host would better help in manipulating crop productivity under changing climatic conditions. Therefore, the present review highlights current research trends based on the SCOPUS database, potential biotechnological interventions of endophytic microorganisms in combating environmental stresses influencing crop productivity, future opportunities of endophytes in improving plant stress tolerance, and their contribution to sustainable remediation of hazardous environmental contaminants. + © 2023. The Author(s). + + + + Anand + Uttpal + U + http://orcid.org/0000-0001-5924-7866 + + Zuckerberg Institute for Water Research, The Jacob Blaustein Institutes for Desert Research, Ben-Gurion University of the Negev, Sede Boqer Campus, 8499000, Midreshet Ben-Gurion, Israel. ushuats@gmail.com. + + + + Pal + Tarun + T + + Zuckerberg Institute for Water Research, The Jacob Blaustein Institutes for Desert Research, Ben-Gurion University of the Negev, Sede Boqer Campus, 8499000, Midreshet Ben-Gurion, Israel. + + + + Yadav + Niraj + N + + French Associates Institute for Agriculture and Biotechnology of Drylands, The Jacob Blaustein Institutes for Desert Research, Ben-Gurion University of the Negev, Sde Boker Campus, 8499000, Midreshet Ben-Gurion, Israel. + + + + Singh + Vipin Kumar + VK + + Department of Botany, K.S. Saket P.G. College, Ayodhya affiliated to Dr. Rammanohar Lohia Avadh University, Ayodhya, 224123, Uttar Pradesh, India. + + + + Tripathi + Vijay + V + + Department of Molecular and Cellular Engineering, Jacob Institute of Biotechnology and Bioengineering, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj, 211007, Uttar Pradesh, India. + + + + Choudhary + Krishna Kumar + KK + + Department of Botany, Mahila Mahavidyalaya, Banaras Hindu University, Varanasi, 221005, Uttar Pradesh, India. + + + + Shukla + Awadhesh Kumar + AK + + Department of Botany, K.S. Saket P.G. College, Ayodhya affiliated to Dr. Rammanohar Lohia Avadh University, Ayodhya, 224123, Uttar Pradesh, India. + + + + Sunita + Kumari + K + + Department of Botany, Deen Dayal Upadhyay Gorakhpur University, Gorakhpur, Uttar Pradesh, 273009, India. + + + + Kumar + Ajay + A + + Department of Postharvest Science, Agricultural Research Organization, The Volcani Center, P.O. Box 15159, 7505101, Rishon, Lezion, Israel. + + + + Bontempi + Elza + E + http://orcid.org/0000-0003-1656-7506 + + INSTM and Chemistry for Technologies Laboratory, University of Brescia, Via Branze 38, 25123, Brescia, Italy. elza.bontempi@unibs.it. + + + + Ma + Ying + Y + + Centre for Functional Ecology, Department of Life Sciences, University of Coimbra, Calçada Martim de Freitas, 3000-456, Coimbra, Portugal. + + + + Kolton + Max + M + http://orcid.org/0000-0002-8166-3572 + + French Associates Institute for Agriculture and Biotechnology of Drylands, The Jacob Blaustein Institutes for Desert Research, Ben-Gurion University of the Negev, Sde Boker Campus, 8499000, Midreshet Ben-Gurion, Israel. + + + + Singh + Amit Kishore + AK + + Department of Botany, Bhagalpur National College (A constituent unit of Tilka Manjhi Bhagalpur University), Bhagalpur, 812007, Bihar, India. kishoreamit03@gmail.com. + + + + eng + + Journal Article + Review + + + 2023 + 03 + 14 + +
+ + United States + Microb Ecol + 7500663 + 0095-3628 + + IM + + Bioaccumulation + Bioactive secondary metabolites + Biocontrol + Biotic and abiotic stress + Endophytes + Phytoremediation + +
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+ + + 36917297 + + 2023 + 03 + 14 + +
+ + 1573-2789 + + + 2023 + Mar + 14 + + + Community mental health journal + Community Ment Health J + + Factors Associated with Implementing the Integrated Behavioral Health Care Model and Iraqi Refugees in the USA. + 10.1007/s10597-023-01107-z + + The aim was to identify which factors facilitate providing integrated behavioral health care for Iraqi refugees in nationally recognized community health center in Northern USA. The social-ecological model (SEM) framework guided this qualitative case study exploring the experience of 11 professional staff. Data were collected from June through August 2021 through individual interviews. Eight themes emerged based on the SEM levels: Intrapersonal-gender-driven engagement; interpersonal-the need for discretion and trusting relationship; community-collaboration with community resources and integrator from the community; organizational-holistic care, and long-term care; and policy-insufficient educational preparation. The results highlight components for clinical practice and policymakers regarding a population that is a big consumer of mental health care. Future research should explore other vulnerable populations, the effect of social groups, and the incorporation of community resources as part of the integrated care team. + © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. + + + + Peer + Yifat + Y + http://orcid.org/0000-0003-0456-4762 + + Susan and Alan Solomont School of Nursing, University of Massachusetts, Lowell 113 Wilder Street, Suite 200, Lowell, MA, 01854-3058, USA. Peeryifat@gmail.com. + + + + Koren + Ainat + A + http://orcid.org/0000-0001-9072-9943 + + Susan and Alan Solomont School of Nursing, University of Massachusetts, Lowell 113 Wilder Street, Suite 200, Lowell, MA, 01854-3058, USA. + + + + DiNapoli + Pamela + P + http://orcid.org/0000-0002-9399-5865 + + Department of Nursing, University of New Hampshire, Hewitt Hall, 4 Library Way, Durham, NH, 03824, USA. + + + + Gautam + Ramraj + R + http://orcid.org/0000-0001-9930-102X + + Susan and Alan Solomont School of Nursing, University of Massachusetts, Lowell 113 Wilder Street, Suite 200, Lowell, MA, 01854-3058, USA. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
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Mental health integration: Normalizing team care. Journal of Primary Care & Community Health, 5(1), 55–60. https://doi.org/10.1177/2150131913508983 + + 10.1177/2150131913508983 + + + + Rihab Mousa, Y., & Bipasha, B. (2014). “We came to this country for the future of our children. We have no future”: Acculturative stress among Iraqi refugees in the United States. International Journal of Intercultural Relations, 38, 133–141. https://doi.org/10.1016/j.ijintrel.2013.08.003 + + 10.1016/j.ijintrel.2013.08.003 + + + + Roderick, S. S., Burdette, N., Hurwitz, D., & Yeracaris, P. (2017). Integrated behavioral health practice facilitation in patient centered medical homes: A promising application. Families, Systems & Health: The Journal of Collaborative Family Healthcare, 35(2), 227–237. https://doi.org/10.1037/fsh0000273 + + 10.1037/fsh0000273 + + + + Sallis, J. F., & Owen, N. (2015). Ecological models of health behavior. In K. Glanz, B. K. Rimer, & K. Viswanath (Eds.), Health behavior: Theory, research, and practice (5th ed., pp. 43–64). Jossey-Bass. + + + Sanchez, K., Thompson, S., & Alexander, L. (2010). Current strategies and barriers in integrated health care: A survey of publicly funded providers in Texas. General Hospital Psychiatry, 32(1), 26–32. https://doi.org/10.1016/j.genhosppsych.2009.10.007 + + 10.1016/j.genhosppsych.2009.10.007 + 20114125 + + + + Schlaudt, V. A., Bosson, R., Williams, M. T., German, B., Hooper, L. M., Frazier, V., Carrico, R., & Ramirez, J. (2020). Traumatic experiences and mental health risk for refugees. International Journal of Environmental Research and Public Health, 17(6), 1943. https://doi.org/10.3390/ijerph17061943 + + 10.3390/ijerph17061943 + 32188119 + 7143439 + + + + Shepardson, R. L., Johnson, E. M., Possemato, K., Arigo, D., & Funderburk, J. S. (2019). Perceived barriers and facilitators to implementation of peer support in veterans health administration Primary Care-Mental Health Integration settings. Psychological Services, 16(3), 433–444. https://doi.org/10.1037/ser0000242 + + 10.1037/ser0000242 + 30407053 + + + + Swavely, D., O’Gurek, D. T., Whyte, V., Schieber, A., Daohai, Y., Tien, A. Y., Freeman, S. L., & Yu, D. (2020). Primary care practice redesign: Challenges in improving behavioral health care for a vulnerable patient population. American Journal of Medical Quality, 35(2), 101–109. + + 10.1177/1062860619855136 + 31226884 + + + + Taylor, E., Yanni, E., Pezzi, C., Guterbock, M., Rothney, E., Harton, E., Montour, J., Elias, C., & Burke, H. (2014). Physical and mental health status of Iraqi refugees resettled in the United States. Journal of Immigrant & Minority Health, 16(6), 1130–1137. https://doi.org/10.1007/s10903-0139893-6 + + 10.1007/s10903-0139893-6 + + + + Thota, A. B., Sipe, T. A., Byard, G. J., Zometa, C. S., Hahn, R. A., McKnight-Eily, L. R., Chapman, D. P., Abraido Lanza, A. F., Pearson, J. L., Anderson, C. W., Gelenberg, A. J., Hennessy, K. D., Duffy, F. F., Vernon Smiley, M. E., Nease, D. E., Jr., & Williams, S. P. (2012). Collaborative care to improve the management of depressive disorders: A community guide systematic review and meta-analysis. American Journal of Preventive Medicine, 42(5), 525–538. https://doi.org/10.1016/j.amepre.2012.01.019 + + 10.1016/j.amepre.2012.01.019 + 22516495 + + + + Willard, C. L., Rabin, M., & Lawless, M. (2014). The prevalence of torture and associated symptoms in United States Iraqi refugees. Journal of Immigrant and Minority Health, 16(6), 1069–1076. https://doi.org/10.1007/s10903-013-9817-5 + + 10.1007/s10903-013-9817-5 + 23564397 + + + + Yin, R. K. (2014). Case study research: Design and method (5th ed.). Sage. + + + Zivin, K., Miller, B. F., Finke, B., Bitton, A., Payne, P., Stowe, E. C., Reddy, A., Day, T. J., Lapin, P., Jin, J. L., & Sessums, L. L. (2017). Behavioral health and the comprehensive primary care (CPC) initiative: Findings from the 2014 CPC behavioral health survey. BMC Health Services Research, 17, 1. + + 10.1186/s12913-017-2562-z + + + + Zubkoff, L., Shiner, B., & Watts, B. V. (2016). Staff perceptions of substance use disorder treatment in VA primary care-mental health integrated clinics. Journal of Substance Abuse Treatment, 70, 44–49. https://doi.org/10.1016/j.jsat.2016.07.01 + + 10.1016/j.jsat.2016.07.01 + 27692187 + + + + +
+ + + 36917300 + + 2023 + 03 + 14 + +
+ + 1432-0932 + + + 2023 + Mar + 14 + + + European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society + Eur Spine J + + Adjacent segment mobility after ACDF considering fusion status at the implant insertion site. + 10.1007/s00586-023-07634-3 + + This paper sets out to analyse mobility changes in segments adjacent to the operated segment. Additionally, it investigates the relationship between the degree of fusion in the operated disc space and mobility changes in the adjacent segments. + In total, 170 disc spaces were operated on in 104 consecutive patients qualified for one- or two-level surgery. The degree of mobility of segments directly above and below the implant insertion site was calculated. Measurements were performed the day before the surgery and 12 months post-surgery. Functional (flexion and extension) radiographs of the cervical spine and CT scans obtained 12 months post-surgery were used to evaluate the fusion status. The results were subjected to statistical analysis. + Statistically significant increase in mobility was recorded for the segments situated immediately below the operative site, with a mean change in mobility of 1.7 mm. Complete fusion was demonstrated in 101 cases (71.1%), and partial fusion in 43 cases (29.9%). In the complete fusion subgroup, the ranges of both flexion and extension in the segments directly below the operative site were significantly greater than those in the partial fusion (pseudoarthrosis) subgroup. + The mobility of the adjacent segment below the implant insertion site was significantly increased at 12 months post-ACDF surgery. The range of this compensatory hypermobility was significantly greater in patients with complete fusion at the ACDF site than in cases of pseudoarthrosis. Implant subsidence was not associated with mobility changes in the segments directly above or directly below the site of ACDF surgery. + © 2023. The Author(s). + + + + Godlewski + Bartosz + B + http://orcid.org/0000-0003-0673-1480 + + Department of Orthopaedics and Traumatology, with Spinal Surgery Ward, Scanmed - St. Raphael Hospital in Cracow, ul. Adama Bochenka 12, 30-693, Cracow, Poland. bartoszgodlewski@wp.pl. + + + + Bebenek + Adam + A + http://orcid.org/0000-0002-6687-1517 + + Department of Orthopaedics and Traumatology, with Spinal Surgery Ward, Scanmed - St. Raphael Hospital in Cracow, ul. Adama Bochenka 12, 30-693, Cracow, Poland. + + + + Dominiak + Maciej + M + http://orcid.org/0000-0002-5109-4970 + + Department of Orthopaedics and Traumatology, with Spinal Surgery Ward, Scanmed - St. Raphael Hospital in Cracow, ul. Adama Bochenka 12, 30-693, Cracow, Poland. + + + + Bochniak + Marcin + M + http://orcid.org/0000-0001-7811-2852 + + Department of Orthopaedics and Traumatology, with Spinal Surgery Ward, Scanmed - St. Raphael Hospital in Cracow, ul. Adama Bochenka 12, 30-693, Cracow, Poland. + + + + Cieslik + Piotr + P + http://orcid.org/0000-0002-4545-4845 + + Department of Orthopaedics and Traumatology, Military Institute of Medicine, Warsaw, Poland. + + + + Pawelczyk + Tomasz + T + http://orcid.org/0000-0002-1421-2050 + + Department of Affective and Psychotic Disorders, Medical University of Lodz, Lodz, Poland. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Eur Spine J + 9301980 + 0940-6719 + + IM + + ACDF + Adjacent segment degeneration + Cervical spine + Fusion rate + Motion compensation + +
+ + + + 2022 + 12 + 28 + + + 2023 + 03 + 03 + + + 2023 + 02 + 14 + + + 2023 + 3 + 14 + 12 + 16 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917300 + 10.1007/s00586-023-07634-3 + 10.1007/s00586-023-07634-3 + + + + Schwab JS, Diangelo DJ, Foley KT (2006) Motion compensation associated with single-level cervical fusion: where does the lost motion go? Spine 31(21):2439–2448. https://doi.org/10.1097/01.brs.0000239125.54761.23 + + 10.1097/01.brs.0000239125.54761.23 + 17023853 + + + + Yang X, Donk R, Arts MP, Arnts H, Walraevens J, Zhai Z, Depreitere B, Bartels RHMA, Vleggeest-Lankamp CLA (2019) Maintaining range of motion after cervical discectomy does not prevent adjacent segment degeneration. Spine J 19(11):1816–1823. https://doi.org/10.1016/j.spinee.2019.07.011 + + 10.1016/j.spinee.2019.07.011 + 31326630 + + + + Alhashash M, Shousha M, Boehm H (2018) Adjacent segment disease after cervical spine fusion: evaluation of a 70 patient long-term follow-up. Spine 43(9):605–609. https://doi.org/10.1097/brs.0000000000002377 + + 10.1097/brs.0000000000002377 + 28816821 + + + + Godlewski B, Bebenek A, Dominiak M, Karpinski G, Cieslik P, Pawelczyk T (2022) PEEK versus titanium-coated PEEK cervical cages: fusion rate. Acta Neurochir (Wien) 164(6):1501–1507. https://doi.org/10.1007/s00701-022-05217-7 + + 10.1007/s00701-022-05217-7 + 35471708 + + + + Godlewski B, Bebenek A, Dominiak M, Bochniak M, Cieslik P, Pawelczyk T (2022) Reliability and utility of various methods for evaluation of bone union after anterior cervical discectomy and fusion. J Clin Med 11(20):6066. https://doi.org/10.3390/jcm11206066 + + 10.3390/jcm11206066 + 36294384 + 9605251 + + + + Battié MC, Videman T, Kaprio J, Gibbons LE, Gill K, Manninen H, Saarela J, Peltonen L (2009) The twin spine study: contributions to a changing view of disc degeneration. Spine J 9(1):47–59. https://doi.org/10.1016/j.spinee.2008.11.011 + + 10.1016/j.spinee.2008.11.011 + 19111259 + + + + Seo M, Choi D (2008) Adjacent segment disease after fusion for cervical spondylosis; myth or reality? Br J Neurosurg 22(2):195–199. https://doi.org/10.1080/02688690701790605 + + 10.1080/02688690701790605 + 18348013 + + + + Cho SK, Riew KD (2013) Adjacent segment disease following cervical spine surgery. J Am Acad Orthop Surg 21(1):3–11. https://doi.org/10.5435/jaaos-21-01-3 + + 10.5435/jaaos-21-01-3 + 23281466 + + + + Hilibrand AS, Carlson GD, Palumbo MA, Jones PK, Bohlman HH (1999) Radiculopathy and myelopathy at segments adjacent to the site of a previous anterior cervical arthrodesis. J Bone Joint Surg Am 81(4):519–528. https://doi.org/10.2106/00004623-199904000-00009 + + 10.2106/00004623-199904000-00009 + 10225797 + + + + Latka D, Kozlowska K, Miekisiak G, Latka K, Chowaniec J, Olbrycht T, Latka M (2019) Safety and efficacy of cervical disc arthroplasty in preventing the adjacent segment disease: a meta-analysis of mid- to long-term outcomes in prospective, randomized, controlled multicenter studies. Ther Clin Risk Manag 15:531–539. https://doi.org/10.2147/tcrm.s196349 + + 10.2147/tcrm.s196349 + 30992666 + 6445235 + + + + Goffin J, Geusens E, Vantomme N, Quintens E, Waerzeggers Y, Depreitere B, van Calanbergh F, van Loon J (2004) Long-term follow-up after interbody fusion of the cervical spine. J Spinal Disord Tech 17(2):79–85. https://doi.org/10.1097/00024720-200404000-00001 + + 10.1097/00024720-200404000-00001 + 15260088 + + + + Chen SR, LeVasseur CM, Pitcairn S, Kanter AS, Okonkwo DO, Shaw JD, Donaldson WF, Lee JY, Anderst WJ (2021) Surgery-related factors do not affect short-term adjacent segment kinematics after anterior cervical arthrodesis. Spine 46(23):1630–1636. https://doi.org/10.1097/brs.0000000000004080 + + 10.1097/brs.0000000000004080 + 33907081 + 8536797 + + + + Godlewski B, Stachura MK, Czepko RA, Banach M, Czepko R (2018) Analysis of changes in cervical spinal curvature and intervertebral disk space height following ACDF surgery in a group of 100 patients followed up for 12 months. J Clin Neurosci 52:92–99. https://doi.org/10.1016/j.jocn.2018.04.005 + + 10.1016/j.jocn.2018.04.005 + 29656879 + + + + Yang X, Bartels RHMA, Donk R, Arts MP, Goedmakers CMW, Vleggeert-Lankamp CLA (2020) The association of cervical sagittal alignment with adjacent segment degeneration. Eur Spine J 29(11):2655–2664. https://doi.org/10.1007/s00586-019-06157-0 + + 10.1007/s00586-019-06157-0 + 31606815 + + + + Boden SD, McCowin PR, Davis DO, Dina TS, Mark AS, Wiesel S (1990) Abnormal magnetic-resonance scans of the cervical spine in asymptomatic subjects. A prospective investigation. J Bone Joint Surg Am 72(8):1178–1184 + + 10.2106/00004623-199072080-00008 + 2398088 + + + + Gore DR (2001) Roentgenographic findings in the cervical spine in asymptomatic persons: a ten-year follow-up. 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+ + + 36917298 + + 2023 + 03 + 14 + +
+ + 1573-2789 + + + 2023 + Mar + 14 + + + Community mental health journal + Community Ment Health J + + The Acceptability of a Recovery Group Intervention in Acute Inpatient Mental Health Wards. + 10.1007/s10597-023-01110-4 + + The aim of the present study was to evaluate the feasibility and explore the service user experience of a recovery-focused group intervention delivered in acute inpatient wards in a National Health Service (NHS) Trust in England, United Kingdom. Feedback from the Recovery Group Questionnaire given to patients who had attended the Recovery Group whilst admitted to acute inpatient wards was collated and analysed. The results suggest that patients found the group useful and supportive, as well as easy to follow. Themes which emerged from the content analysis included, value, challenges, support and understanding. The feedback also showed that patients found having an Expert by Experience co-facilitating was beneficial. The Recovery Group is an acceptable and feasible group intervention for those who are admitted to acute inpatient wards. Further research examining the clinical effectiveness of the intervention may be considered, however there are some barriers to doing so given the open-access format of the group. + © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. + + + + Pownell + Katie + K + http://orcid.org/0000-0001-8347-9261 + + Principal Clinical Psychologist, Clock View Hospital, Mersey Care NHS Foundation Trust, Liverpool, UK. katie.pownell@merseycare.nhs.uk. + + + Acute Care Psychology, Clock View Hospital, 2a Oakhouse Park, Liverpool, L9 1EP, UK. katie.pownell@merseycare.nhs.uk. + + + + Sarsam + May + M + + Clinical Psychologist; Cheshire and Merseyside Resilience Hub, Mersey Care NHS Foundation Trust, Liverpool, UK. + + + + Hannah + Kate + K + + Assistant Psychologist, Clock View Hospital, Mersey Care NHS Foundation Trust, Liverpool, UK. + + + + Horner + Gillian + G + + Assistant Psychologist, Clock View Hospital, Mersey Care NHS Foundation Trust, Liverpool, UK. + + + + Villanueva + Timothy + T + + Assistant Psychologist, Clock View Hospital, Mersey Care NHS Foundation Trust, Liverpool, UK. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Community Ment Health J + 0005735 + 0010-3853 + + IM + + Brief Psychotherapy + Inpatient + Psychiatric Hospital + Psychological Group + Recovery + Thematic Analysis + +
+ + + + 2022 + 06 + 01 + + + 2023 + 03 + 03 + + + 2023 + 3 + 14 + 12 + 16 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917298 + 10.1007/s10597-023-01110-4 + 10.1007/s10597-023-01110-4 + + + + Akther, S. F., Molyneaux, E., Stuart, R., Johnson, S., Simpson, A., & Oram, S. (2019). Patients’ experiences of assessment and detention under mental health legislation: systematic review and qualitative meta-synthesis. BJPsych Open, 5, e37, 1–10. doi: https://doi.org/10.1192/bjo.2019.19 + + + Bartholomew, T., Gildar, L., Carrick, G., Saafigueroa, A., & Cook, R. (2018). Using recovery-oriented principles to improve consumer empowerment in a state Psychiatric Hospital. Journal of psychosocial nursing and mental health services, 56(5), 40–45. + + 10.3928/02793695-20180212-05 + 29538791 + + + + Braun, V., & Clarke, V. (2006). Using thematic analysis in psychology. Qualitative Research in Psychology, 3 (2). pp. 77–101. 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+ + + 36917301 + + 2023 + 03 + 14 + +
+ + 1432-0932 + + + 2023 + Mar + 14 + + + European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society + Eur Spine J + + Factors associated with incomplete clinical improvement in patients undergoing transforaminal endoscopic lumbar discectomy for lumbar disc herniation. + 10.1007/s00586-023-07636-1 + + To analyze the clinical and radiographic risk factors that might predict incomplete clinical improvement after transforaminal endoscopic lumbar discectomy (TELD). + A retrospective analysis was conducted from 194 consecutive patients who underwent TELD due to lumbar disc herniation (LDH). Patients with incomplete clinical improvement were defined from patient-reported outcomes of poor improvement in pain or disability after surgery and patient dissatisfaction. Clinical and radiographic characteristics were evaluated to identify predicting factors of poor outcomes. + Of 194 patients who underwent TELD procedures, 32 patients (16.5%) had incomplete clinical improvement and 12 patients (6.1%) required revision surgery. The mean ages were 46.4 years and most of the patients suffered from predominant leg pain (48.9%). The most common surgical level was L4-5 (63.9%). Overall, the Oswestry Disability Index (44.3-15), visual analog scores of back pain (4.9-1.8) and leg pain (7.3-1.6) were significantly improved after surgery. Multivariate logistic regression analysis demonstrated that high body mass index, history of previous surgery, preoperative disability, weakness, and disc degeneration were related to incomplete clinical improvement. There were 15 recurrent LDH (7.7%) with a total of 12 revision surgeries (6.2%). + We identified independent risk factors associated with incomplete clinical improvement following TELD, including overweight, significant preoperative disability or weakness and history of previous surgery. Advanced age, disc degeneration, vacuum phenomenon, and spondylolisthesis were also possible risk factors. Recognizing these risk factors would help decide whether patients are good candidates for TELD, and optimize the surgical planning preoperatively to achieve good surgical results. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Jitpakdee + Khanathip + K + http://orcid.org/0000-0002-5955-0037 + + Department of Orthopaedics, Queen Savang Vadhana Memorial Hospital, Thai Red Cross Society, Chonburi, Thailand. + + + Spine Center, Department of Neurosurgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea. + + + + Liu + Yanting + Y + http://orcid.org/0000-0002-9591-3042 + + Spine Center, Department of Neurosurgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea. + + + + Kim + Young-Jin + YJ + + Spine Center, Department of Neurosurgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea. + + + + Kotheeranurak + Vit + V + http://orcid.org/0000-0002-9593-429X + + Department of Orthopaedics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. + + + Center of Excellence in Biomechanics and Innovative Spine Surgery, Chulalongkorn University, Bangkok, Thailand. + + + + Kim + Jin-Sung + JS + http://orcid.org/0000-0001-5086-0875 + + Spine Center, Department of Neurosurgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea. mdlukekim@gmail.com. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Eur Spine J + 9301980 + 0940-6719 + + IM + + Disc herniation + Endoscopic spine surgery + Endoscopy + Minimally invasive spine surgery + Percutaneous endoscopic lumbar discectomy + Transforaminal endoscopic discectomy + +
+ + + + 2022 + 11 + 22 + + + 2023 + 03 + 04 + + + 2022 + 11 + 22 + + + 2023 + 3 + 14 + 12 + 16 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917301 + 10.1007/s00586-023-07636-1 + 10.1007/s00586-023-07636-1 + + + + Gibson JN, Cowie JG, Iprenburg M (2012) Transforaminal endoscopic spinal surgery: the future “gold standard” for discectomy?—a review. Surgeon 10:290–296. https://doi.org/10.1016/j.surge.2012.05.001 + + 10.1016/j.surge.2012.05.001 + 22705355 + + + + Ahn Y, Lee SH, Lee JH, Kim JU, Liu WC (2009) Transforaminal percutaneous endoscopic lumbar discectomy for upper lumbar disc herniation: clinical outcome, prognostic factors, and technical consideration. Acta Neurochir (Wien) 151:199–206. https://doi.org/10.1007/s00701-009-0204-x + + 10.1007/s00701-009-0204-x + 19229467 + + + + Ruetten S, Komp M, Merk H, Godolias G (2008) Full-endoscopic interlaminar and transforaminal lumbar discectomy versus conventional microsurgical technique: a prospective, randomized, controlled study. Spine (Phila Pa 1976) 33:931–939. https://doi.org/10.1097/BRS.0b013e31816c8af7 + + 10.1097/BRS.0b013e31816c8af7 + 18427312 + + + + Hoogland T, Schubert M, Miklitz B, Ramirez A (2006) Transforaminal posterolateral endoscopic discectomy with or without the combination of a low-dose chymopapain: a prospective randomized study in 280 consecutive cases. Spine (Phila Pa 1976) 31:E890–E897. https://doi.org/10.1097/01.brs.0000245955.22358.3a + + 10.1097/01.brs.0000245955.22358.3a + 17108817 + + + + Kambin P, Sampson S (1986) Posterolateral percutaneous suction-excision of herniated lumbar intervertebral discs. Report of interim results. Clin Orthop Relat Res 207:37–43 + + 10.1097/00003086-198606000-00008 + + + + Kong M, Xu D, Gao C, Zhu K, Han S, Zhang H, Zhou C, Ma X (2020) Risk factors for recurrent L4–5 disc herniation after percutaneous endoscopic transforaminal discectomy: a retrospective analysis of 654 cases. Risk Manag Healthc Policy 13:3051–3065. https://doi.org/10.2147/RMHP.S287976 + + 10.2147/RMHP.S287976 + 33376428 + 7755338 + + + + Ostelo RW, Deyo RA, Stratford P, Waddell G, Croft P, Von Korff M, Bouter LM, de Vet HC (2008) Interpreting change scores for pain and functional status in low back pain: towards international consensus regarding minimal important change. Spine (Phila Pa 1976) 33:90–94. https://doi.org/10.1097/BRS.0b013e31815e3a10 + + 10.1097/BRS.0b013e31815e3a10 + 18165753 + + + + Kim KT, Park SW, Kim YB (2009) Disc height and segmental motion as risk factors for recurrent lumbar disc herniation. Spine (Phila Pa 1976) 34:2674–2678. https://doi.org/10.1097/BRS.0b013e3181b4aaac + + 10.1097/BRS.0b013e3181b4aaac + 19910771 + + + + Jensen TS, Karppinen J, Sorensen JS, Niinimaki J, Leboeuf-Yde C (2008) Vertebral endplate signal changes (Modic change): a systematic literature review of prevalence and association with non-specific low back pain. Eur Spine J 17:1407–1422. https://doi.org/10.1007/s00586-008-0770-2 + + 10.1007/s00586-008-0770-2 + 18787845 + 2583186 + + + + Pfirrmann CW, Metzdorf A, Zanetti M, Hodler J, Boos N (2001) Magnetic resonance classification of lumbar intervertebral disc degeneration. Spine (Phila Pa 1976) 26:1873–1878. https://doi.org/10.1097/00007632-200109010-00011 + + 10.1097/00007632-200109010-00011 + 11568697 + + + + Hoogland T, van den Brekel-Dijkstra K, Schubert M, Miklitz B (2008) Endoscopic transforaminal discectomy for recurrent lumbar disc herniation: a prospective, cohort evaluation of 262 consecutive cases. Spine (Phila Pa 1976) 33:973–978. https://doi.org/10.1097/BRS.0b013e31816c8ade + + 10.1097/BRS.0b013e31816c8ade + 18427318 + + + + Gibson JNA, Subramanian AS, Scott CEH (2017) A randomised controlled trial of transforaminal endoscopic discectomy vs microdiscectomy. Eur Spine J 26:847–856. https://doi.org/10.1007/s00586-016-4885-6 + + 10.1007/s00586-016-4885-6 + 27885470 + + + + Wang YP, Zhang W, An JL, Zhang J, Bai JY, Sun YP (2016) Evaluation of transforaminal endoscopic discectomy in treatment of obese patients with lumbar disc herniation. Med Sci Monit 22:2513–2519. https://doi.org/10.12659/msm.899510 + + 10.12659/msm.899510 + 27425418 + 4962756 + + + + Turk CC, Kara NN, Biliciler B, Karasoy M (2015) Clinical outcomes and efficacy of transforaminal lumbar endoscopic discectomy. J Neurosci Rural Pract 6:344–348. https://doi.org/10.4103/0976-3147.154575 + + 10.4103/0976-3147.154575 + 26167017 + 4481788 + + + + Gadjradj PS, Harhangi BS (2022) Full-endoscopic transforaminal discectomy versus open microdiscectomy for sciatica: update of a systematic review and meta-analysis. Spine (Phila Pa 1976) 47:E591–E594. https://doi.org/10.1097/BRS.0000000000004421 + + 10.1097/BRS.0000000000004421 + 35867477 + + + + Shi H, Zhu L, Jiang ZL, Wu XT (2021) Radiological risk factors for recurrent lumbar disc herniation after percutaneous transforaminal endoscopic discectomy: a retrospective matched case-control study. Eur Spine J 30:886–892. https://doi.org/10.1007/s00586-020-06674-3 + + 10.1007/s00586-020-06674-3 + 33386474 + + + + Kim HS, Yudoyono F, Paudel B, Kim KJ, Jang JS, Choi JH, Chung SK, Kim JH, Jang IT, Oh SH, Park JE, Lee S (2017) Analysis of clinical results of three different routes of percutaneous endoscopic transforaminal lumbar discectomy for lumbar herniated disk. World Neurosurg 103:442–448. https://doi.org/10.1016/j.wneu.2017.04.008 + + 10.1016/j.wneu.2017.04.008 + 28408266 + + + + Nie H, Zeng J, Song Y, Chen G, Wang X, Li Z, Jiang H, Kong Q (2016) Percutaneous endoscopic lumbar discectomy for L5–S1 disc herniation via an interlaminar approach versus a transforaminal approach: a prospective randomized controlled study with 2-year follow up. Spine (Phila Pa 1976) 41(Suppl 19):B30–B37. https://doi.org/10.1097/BRS.0000000000001810 + + 10.1097/BRS.0000000000001810 + 27454540 + + + + Ahn Y (2012) Transforaminal percutaneous endoscopic lumbar discectomy: technical tips to prevent complications. Expert Rev Med Devices 9:361–366. https://doi.org/10.1586/erd.12.23 + + 10.1586/erd.12.23 + 22905840 + + + + Rihn JA, Kurd M, Hilibrand AS, Lurie J, Zhao W, Albert T, Weinstein J (2013) The influence of obesity on the outcome of treatment of lumbar disc herniation: analysis of the spine patient outcomes research trial (SPORT). J Bone Jt Surg Am 95:1–8. https://doi.org/10.2106/JBJS.K.01558 + + 10.2106/JBJS.K.01558 + + + + Hareni N, Strömqvist F, Rosengren BE, Karlsson MK (2022) A study comparing outcomes between obese and nonobese patients with lumbar disc herniation undergoing surgery: a study of the Swedish National Quality Registry of 9979 patients. 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J Orthop Surg (Hong Kong) 28:2309499020960560. https://doi.org/10.1177/2309499020960560 + + 10.1177/2309499020960560 + 32990158 + + + + Abdu RW, Abdu WA, Pearson AM, Zhao W, Lurie JD, Weinstein JN (2017) Reoperation for recurrent intervertebral disc herniation in the spine patient outcomes research trial: analysis of rate, risk factors, and outcome. Spine (Phila Pa 1976) 42:1106–1114. https://doi.org/10.1097/BRS.0000000000002088 + + 10.1097/BRS.0000000000002088 + 28146015 + + + + Ebrahimkhani M, Arjmand N, Shirazi-Adl A (2021) Biomechanical effects of lumbar fusion surgery on adjacent segments using musculoskeletal models of the intact, degenerated and fused spine. Sci Rep 11:17892. https://doi.org/10.1038/s41598-021-97288-2 + + 10.1038/s41598-021-97288-2 + 34504207 + 8429534 + + + + Jiang S, Li W (2019) Biomechanical study of proximal adjacent segment degeneration after posterior lumbar interbody fusion and fixation: a finite element analysis. J Orthop Surg Res 14:135. https://doi.org/10.1186/s13018-019-1150-9 + + 10.1186/s13018-019-1150-9 + 31092257 + 6521416 + + + + Telfeian AE (2017) Transforaminal endoscopic surgery for adjacent segment disease after lumbar fusion. World Neurosurg 97:231–235. https://doi.org/10.1016/j.wneu.2016.09.099 + + 10.1016/j.wneu.2016.09.099 + 27725297 + + + + Kim GU, Park J, Kim HJ, Shen F, Cho J, Chang BS, Lee CK, Chun HJ, Yeom JS (2020) Definitions of unfavorable surgical outcomes and their risk factors based on disability score after spine surgery for lumbar spinal stenosis. BMC Musculoskelet Disord 21:288. https://doi.org/10.1186/s12891-020-03323-0 + + 10.1186/s12891-020-03323-0 + 32384932 + 7206812 + + + + Chen Z, He L, Huang L, Liu Z, Dong J, Liu B, Chen R, Zhang L, Xie P, Rong L (2022) Risk factors for poor outcomes following minimally invasive discectomy: a post hoc subgroup analysis of 2-year follow-up prospective data. Neurospine 19:224–235. https://doi.org/10.14245/ns.2143084.542 + + 10.14245/ns.2143084.542 + 35378590 + 8987556 + + + + Quillo-Olvera J, Akbary K, Kim JS (2018) Percutaneous endoscopic transpedicular approach for high-grade down-migrated lumbar disc herniations. Acta Neurochir (Wien) 160:1603–1607. https://doi.org/10.1007/s00701-018-3586-9 + + 10.1007/s00701-018-3586-9 + 29926249 + + + + Hu QF, Pan H, Fang YY, Jia GY (2018) Percutaneous endoscopic lumbar discectomy for high-grade down-migrated disc using a trans-facet process and pedicle-complex approach: a technical case series. Eur Spine J 27:393–402. https://doi.org/10.1007/s00586-017-5365-3 + + 10.1007/s00586-017-5365-3 + 29119334 + + + + Kim HS, Ju CI, Kim SW, Kim JG (2009) Endoscopic transforaminal suprapedicular approach in high grade inferior migrated lumbar disc herniation. J Korean Neurosurg Soc 45:67–73. https://doi.org/10.3340/jkns.2009.45.2.67 + + 10.3340/jkns.2009.45.2.67 + 19274114 + 2651558 + + + + +
+ + + 36917302 + + 2023 + 03 + 14 + +
+ + 1432-0932 + + + 2023 + Mar + 14 + + + European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society + Eur Spine J + + Lateral versus posterior approaches to treat degenerative lumbar pathologies-systematic review and meta-analysis of recent literature. + 10.1007/s00586-023-07619-2 + + The lateral lumbar interbody fusion arose as a revolutionary approach to treating several spinal pathologies because the techniques were able to promote indirect decompression and lordosis restoration through a minimally invasive approach allowing for reduced blood loss and early recovery for patients. However, it is still not clear how the technique compares to other established approaches for treating spinal degenerative diseases, such as TLIF, PLIF, and PLF. + This is a systematic review and meta-analysis of articles published in the last 10 years comparing lateral approaches to posterior techniques. The authors included articles that compared the LLIF technique to one or more posterior approaches, treating only degenerative pathologies, and containing at least one of the key outcomes of the study. Exclusion articles that were not original and the ones that the authors could not obtain the full text; also articles without the possibility to calculate the standard deviation or mean were excluded. For count variables, the odds ratio was used, and for continuous variables, the standard means difference (SMD) was used, and the choice between random or fixed-effects model was made depending on the presence or not of significant (p < 0.05) heterogeneity in the sample. + Twenty-four articles were included in the quantitative review. As for the intra-/perioperative variables, the lateral approaches showed a significant reduction in blood loss (SMD-1.56, p < 0.001) and similar operative time (SMD =  - 0.33, p = 0.24). Moreover, the use of the lateral approaches showed a tendency to lead to reduced hospitalization days (SMD =  - 0.15, p = 0.09), with significantly reduced odds ratios of complications (0.53, p = 0.01). As for the clinical outcomes, both approaches showed similar improvement both at improvement as for the last follow-up value, either in ODI or in VAS-BP. Finally, when analyzing the changes in segmental lordosis and lumbar lordosis, the lateral technique promoted significantly higher correction in both outcomes (p < 0.05). + Lateral approaches can promote significant radiological correction and similar clinical improvement while reducing surgical blood loss and postoperative complications. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Amaral + Rodrigo + R + + Instituto de Patologia da Coluna, São Paulo, SP, Brazil. + + + + Pokorny + Gabriel + G + http://orcid.org/0000-0002-7907-8032 + + Instituto de Patologia da Coluna, São Paulo, SP, Brazil. g.pokorny@patologiadacoluna.com.br. + + + + Marcelino + Fernando + F + + Instituto de Patologia da Coluna, São Paulo, SP, Brazil. + + + + Moriguchi + Rafael + R + + Instituto de Patologia da Coluna, São Paulo, SP, Brazil. + + + + Pokorny + Jullyene + J + + Instituto de Patologia da Coluna, São Paulo, SP, Brazil. + + + + Barreira + Igor + I + + Instituto de Patologia da Coluna, São Paulo, SP, Brazil. + + + + Mizael + Weby + W + + Instituto de Patologia da Coluna, São Paulo, SP, Brazil. + + + + Yozo + Marcelo + M + + Instituto de Patologia da Coluna, São Paulo, SP, Brazil. + + + + Fragoso + Sebastião + S + + Instituto de Patologia da Coluna, São Paulo, SP, Brazil. + + + + Pimenta + Luiz + L + + Instituto de Patologia da Coluna, São Paulo, SP, Brazil. + + + + eng + + Journal Article + Review + + + 2023 + 03 + 14 + +
+ + Germany + Eur Spine J + 9301980 + 0940-6719 + + IM + + LLIF + PLF + PLIF + Systematic review + TLIF + +
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+ + + 36917304 + + 2023 + 03 + 14 + +
+ + 1573-4838 + + 34 + 3 + + 2023 + Mar + 14 + + + Journal of materials science. Materials in medicine + J Mater Sci Mater Med + + Biomimetic vascular tissue engineering by decellularized scaffold and concurrent cyclic tensile and shear stresses. + + 12 + + 10.1007/s10856-023-06716-4 + + Decellularization by chemical approaches has harmful effects on extracellular matrix (ECM) proteins, and damages lots of functional peptides and biomolecules present in the ultrastructure. In this study, we employed a combination of chemical and physical decellularization methods to overcome these disadvantages. The induced osmotic pressure by hypertonic/hypotonic solutions dissociated and removed most of cellular membranes significantly without any detergent or chemical agent. In total, 0.025% trypsin solution was found adequate to remove the remaining debrides, and ultimately 1% Triton X-100 was utilized for final cleansing. In addition, conducting all the decellularization processes at 4 °C yielded an ECM with least damages in the ultrastructure which could be inferred by close mechanical strength and swelling ratio to the native vessel, and high quality and quantity of cell attachment, migration and proliferation which were examined by optical microscopy and scanning electron microscopy (SEM) of the histology samples. Moreover, the obtained biological scaffold (BS) had no cytotoxicity according to the MTT assay, and this scaffold is storable at -20 °C. Employing bioreactor for concurrent cyclic tensile and shear stresses improved the cell migration into pores of the BS and made the cells and the scaffold compact in analogous to native tissue. As opening angle test showed by decellularizing of the blood vessel, the residual stress dropped significantly which revealed the role of cells in the amount of induced stress in the structure. However, intact and healthy ECM explicitly recovered upon recellularization and beat the initial residual stress of the native tissue. The tensile test of the blood vessels in longitudinal and radial directions revealed orthotropic behavior which can be explained by collagen fibers direction in the ECM. Furthermore, by the three regions of the stress-strain curve can be elucidated the roles of cells, elastin and collagen fibers in mechanical behavior of the vascular tissues. + © 2023. The Author(s). + + + + Omid + Hamed + H + + Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran. + + + National Cell Bank of Iran, Pasteur Institute of Iran, No. 69, Pasteur Ave, Tehran, 1316943551, Iran. + + + + Abdollahi + Sorosh + S + + School of Metallurgy and Materials Engineering, Iran University of Science and Technology, Tehran, Iran. + + + + Bonakdar + Shahin + S + + National Cell Bank of Iran, Pasteur Institute of Iran, No. 69, Pasteur Ave, Tehran, 1316943551, Iran. + + + + Haghighipour + Nooshin + N + + National Cell Bank of Iran, Pasteur Institute of Iran, No. 69, Pasteur Ave, Tehran, 1316943551, Iran. + + + + Shokrgozar + Mohammad Ali + MA + + National Cell Bank of Iran, Pasteur Institute of Iran, No. 69, Pasteur Ave, Tehran, 1316943551, Iran. mashokrgozar@pasteur.ac.ir. + + + + Mohammadi + Javad + J + + Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran. javad.mohammadi@ut.ac.ir. + + + + eng + + + 984206 + National Institute for Medical Development + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + J Mater Sci Mater Med + 9013087 + 0957-4530 + + IM +
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+ + Germany + Clin Rheumatol + 8211469 + 0770-3198 + + IM + + + Clin Rheumatol. 2023 Feb 1;: + 36725780 + + +
+ + + + 2023 + 02 + 18 + + + 2023 + 02 + 23 + + + 2023 + 02 + 18 + + + 2023 + 3 + 14 + 12 + 16 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917308 + 10.1007/s10067-023-06561-4 + 10.1007/s10067-023-06561-4 + + + + Şen N et al (2023) Apical fibrosis was the most common incidental pulmonary finding in a familial Mediterranean fever cohort. Clin Rheumatol. https://doi.org/10.1007/s10067-023-06526-7 + + 10.1007/s10067-023-06526-7 + 36725780 + 9891658 + + + + Atas N et al (2020) Familial Mediterranean fever is associated with a wide spectrum of inflammatory disorders: results from a large cohort study. Rheumatol Int 40(1):41–48. https://doi.org/10.1007/s00296-019-04412-7 + + 10.1007/s00296-019-04412-7 + 31392498 + + + + Kelesoglu FM et al (2016) Evaluation of subclinical inflammation in familial Mediterranean fever patients: relations with mutation types and attack status: a retrospective study. Clin Rheumatol. https://doi.org/10.1007/s10067-016-3275-0 + + 10.1007/s10067-016-3275-0 + 27106545 + + + + +
+ + + 36917303 + + 2023 + 03 + 14 + +
+ + 1573-7217 + + + 2023 + Mar + 14 + + + Breast cancer research and treatment + Breast Cancer Res Treat + + Implications for surveillance for breast cancer patients based on the internally and externally validated BRENDA-metastatic recurrence score. + 10.1007/s10549-023-06898-z + + Although the incidence of distant relapse is decreasing, 20-30% of patients with early breast cancer die of metastasis. The aim of this study is to characterize patients with metastasis-free survival(MFS) less than 5 years, to analyze the most probable site of metastases according to the internally and externally validated BRENDA-score. The BRENDA-score is a combination of the biological subtype and clinical staging. + 3832 patients with primary diagnosis of breast cancer and either distant metastatic recurrence within 5 years or MFS ≥ 5 years were assigned to this study. Patients were classified for metastatic recurrence according to the BRENDA-score. 1765 patients were in a validation set. Statistical methods were Kaplan-Meier curves, Cox regression analysis, Exhausted CHAID, likelihood-ratio tests and the Nearest Neighbor Estimation method. + There was a significant(p < 0.001) difference between the Kaplan-Meier MFS-functions of M0-patients stratified by BRENDA-score. The BRENDA score outperforms intrinsic subtypes and the Nottingham prognostic score. It fits the original data and the validation set equally well (p = 0.179).There was a significant(p < 0.001) difference between mean BRENDA-Index for patients with MFS < 5y(21.0 ± 9.0) and patients with MFS ≥ 5y(mean BRENDA-Index 11.7 ± 8.2). 55.6% of the very high risk patients(BRENDA-Index ≥ 27) had metastases within 5 years. The most likely primary metastatic site was bone(30%) followed by liver(19%) and lung(18%). The discriminatory ability(areas under the time dependent ROC curve) of the BRENDA score is good to acceptable for the first 5 years. In the very low/low risk (intermediate, high/very high) risk group 50% of all metastases were diagnosed within 26 months. Guideline adherence had a highly significant influence on outcome independent of the risk group. + The evaluation showed that the BRENDA-Score is a robust predictive tool for breast cancer recurrence and site of metastases in the first five years after diagnosis. It outperforms intrinsic subtypes and the Nottingham prognostic score. The BRENDA-score could be a tool for a risk orientated and targeted follow up. + © 2023. The Author(s). + + + + Ebner + Florian + F + http://orcid.org/0000-0003-2066-5344 + + Universität Ulm, Prittwitzstr. 43, 890, Ulm, Germany. ebner@gyn-freising.de. + + + Gyn-Freising, Marienplatz 5, 85354, Freising, Germany. ebner@gyn-freising.de. + + + + Salmen + Jessica + J + + Universitätsfrauenklinik Würzburg, Würzburg, Germany. + + + + Dayan + Davut + D + + Universität Ulm, Prittwitzstr. 43, 890, Ulm, Germany. + + + + Kiesel + Matthias + M + + Universitätsfrauenklinik Würzburg, Würzburg, Germany. + + + + Wolters + Regine + R + + FB Mathematik u. Informatik, Universität Bremen, Bibliothekar. 1, 28359, Bremen, Germany. + + + + Janni + Wolfgang + W + + Universität Ulm, Prittwitzstr. 43, 890, Ulm, Germany. + + + + Wöckel + Achim + A + + Universitätsfrauenklinik Würzburg, Würzburg, Germany. + + + + Wischnewsky + Manfred + M + + FB Mathematik u. Informatik, Universität Bremen, Bibliothekar. 1, 28359, Bremen, Germany. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Netherlands + Breast Cancer Res Treat + 8111104 + 0167-6806 + + IM + + Breast cancer + Follow up + Prediction + Prognostic + Recurrence + +
+ + + + 2022 + 09 + 12 + + + 2023 + 02 + 16 + + + 2023 + 3 + 14 + 12 + 16 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917303 + 10.1007/s10549-023-06898-z + 10.1007/s10549-023-06898-z + + + + Bychkovsky BL, Lin NU (2017) Imaging in the evaluation and follow-up of early and advanced breast cancer: When, why, and how often? Breast 1(31):318–324 + + 10.1016/j.breast.2016.06.017 + + + + Hahn EE, Tang T, Lee JS, Munoz-Plaza CE, Shen E, Rowley B et al (2016) Use of posttreatment imaging and biomarkers in survivors of early-stage breast cancer: Inappropriate surveillance or necessary care? Cancer 122(6):908–916 + + 10.1002/cncr.29811 + 26650715 + + + + Kast K, Link T, Friedrich K, Petzold A, Niedostatek A, Schoffer O et al (2015) Impact of breast cancer subtypes and patterns of metastasis on outcome. 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Sci Rep 10:1. https://doi.org/10.1038/s41598-020-67393-9 + + 10.1038/s41598-020-67393-9 + + + + Tzanikou E, Lianidou E (2020) The potential of ctDNA analysis in breast cancer. Crit Rev Clin Lab Sci 57:54–72. https://doi.org/10.1080/10408363.2019.1670615 + + 10.1080/10408363.2019.1670615 + 31674269 + + + + +
+ + + 36917306 + + 2023 + 03 + 14 + +
+ + 1432-2048 + + 257 + 4 + + 2023 + Mar + 14 + + + Planta + Planta + + Analysis of durum wheat photosynthetic organs during grain filling reveals the ear as a water stress-tolerant organ and the peduncle as the largest pool of primary metabolites. + + 81 + + 10.1007/s00425-023-04115-1 + + The pool of carbon- and nitrogen-rich metabolites is quantitatively relevant in non-foliar photosynthetic organs during grain filling, which have a better response to water limitation than flag leaves. The response of durum wheat to contrasting water regimes has been extensively studied at leaf and agronomic level in previous studies, but the water stress effects on source-sink dynamics, particularly non-foliar photosynthetic organs, is more limited. Our study aims to investigate the response of different photosynthetic organs to water stress and to quantify the pool of carbon and nitrogen metabolites available for grain filling. Five durum wheat varieties were grown in field trials in the Spanish region of Castile and León under irrigated and rainfed conditions. Water stress led to a significant decrease in yield, biomass, and carbon and nitrogen assimilation, improved water use efficiency, and modified grain quality traits in the five varieties. The pool of carbon (glucose, glucose-6-phosphate, fructose, sucrose, starch, and malate) and nitrogen (glutamate, amino acids, proteins and chlorophylls) metabolites in leaf blades and sheaths, peduncles, awns, glumes and lemmas were also analysed. The results showed that the metabolism of the blades and peduncles was the most susceptible to water stress, while ear metabolism showed higher stability, particularly at mid-grain filling. Interestingly, the total metabolite content per organ highlighted that a large source of nutrients, which may be directly involved in grain filling, are found outside the blades, with the peduncles being quantitatively the most relevant. We conclude that yield improvements in our Mediterranean agro-ecosystem are highly linked to the success of shoots in producing ears and a higher number of grains, while grain filling is highly dependent on the capacity of non-foliar organs to fix CO2 and N. The ear organs show higher stress resilience than other organs, which deserves our attention in future breeding programmes. + © 2023. The Author(s). + + + + Martínez-Peña + Raquel + R + + Cereals Group, Section of Herbaceous, Agro-Technological Institute of Castile and León, Junta de Castile and León, Valladolid, Spain. + + + + Vergara-Díaz + Omar + O + + Plant Ecophysiology and Metabolism Group, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa (ITQB NOVA), Oeiras, Portugal. + + + + Schlereth + Armin + A + + Max Planck Institute of Molecular Plant Physiology, Potsdam, Germany. + + + + Höhne + Melanie + M + + Max Planck Institute of Molecular Plant Physiology, Potsdam, Germany. + + + + Morcuende + Rosa + R + + Institute of Natural Resources and Agrobiology of Salamanca (IRNASA), Consejo Superior de Investigaciones Científicas (CSIC), Salamanca, Spain. + + + + Nieto-Taladriz + María Teresa + MT + + Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Consejo Superior de Investigaciones Científicas, Madrid, Spain. + + + + Araus + José Luis + JL + + Integrative Crop Ecophysiology Group, Section of Plant Physiology, Faculty of Biology, University of Barcelona, Barcelona, and AGROTECNIO-CERCA Center, Lleida, Spain. + + + + Aparicio + Nieves + N + + Cereals Group, Section of Herbaceous, Agro-Technological Institute of Castile and León, Junta de Castile and León, Valladolid, Spain. + + + + Vicente + Rubén + R + http://orcid.org/0000-0001-5469-2645 + + Plant Ecophysiology and Metabolism Group, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa (ITQB NOVA), Oeiras, Portugal. vicenteperez.ruben@gmail.com. + + + Max Planck Institute of Molecular Plant Physiology, Potsdam, Germany. vicenteperez.ruben@gmail.com. + + + + eng + + + PID2019-106650RB-C2 + Spanish Ministry of Science and Innovation + + + + PID2019-107154RB-I00 + Spanish Ministry of Science and Innovation + + + + CSI260P20 + Junta de Castilla y León + + + + CLU-2019-05-IRNASA/CSIC + Junta de Castilla y León + + + + UIDB/04551/2020 + Fundação para a Ciência e a Tecnologia + + + + UIDP/04551/2020 + Fundação para a Ciência e a Tecnologia + + + + LA/P/0087/2020 + Fundação para a Ciência e a Tecnologia + + + + CPD2016-0107 + Spanish Ministry of Science and Innovation + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Planta + 1250576 + 0032-0935 + + IM + + Carbon metabolism + Drought + Field trial + Mediterranean region + Nitrogen metabolism + Source–sink dynamics + +
+ + + + 2022 + 08 + 16 + + + 2023 + 03 + 04 + + + 2023 + 3 + 14 + 12 + 16 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917306 + 10.1007/s00425-023-04115-1 + 10.1007/s00425-023-04115-1 + + + + Agati G, Brunetti C, Fini A, Gori A, Guidi L, Landi M, Sebastiani F, Tattini M (2020) Are flavonoids effective antioxidants in plants? Twenty Years Investigat Antioxid 9(11):1098. https://doi.org/10.3390/antiox9111098 + + 10.3390/antiox9111098 + + + + Araus JL, Santiveri P, Bosch-Serra D, Royo C, Romagosa I (1992) Carbon isotope ratios in ear parts of triticale: influence of grain filling. Plant Physiol 100(2):1033–1035. https://doi.org/10.1104/pp.100.2.1033 + + 10.1104/pp.100.2.1033 + 16653012 + 1075661 + + + + Araus JL, Brown HR, Febrero A, Bort J, Serret MD (1993) Ear photosynthesis, carbon isotope discrimination and the contribution of respiratory CO2 to differences in grain mass in durum wheat. Plant Cell Environ 16(4):383–392. https://doi.org/10.1111/j.1365-3040.1993.tb00884.x + + 10.1111/j.1365-3040.1993.tb00884.x + + + + Araus JL, Bort J, Steduto P, Villegas D, Royo C (2003) Breeding cereals for Mediterranean conditions: ecophysiological clues for biotechnology application. Ann Appl Biol 142(2):129–141. https://doi.org/10.1111/j.1744-7348.2003.tb00238.x + + 10.1111/j.1744-7348.2003.tb00238.x + + + + Araus JL, Sanchez-Bragado R, Vicente R (2021) Improving crop yield and resilience through photosynthesis optimisation: panacea or pipe dream? J Exp Bot 72(11):3936–3955. https://doi.org/10.1093/jxb/erab097 + + 10.1093/jxb/erab097 + 33640973 + + + + Araus JL, Kefauver SC, Vergara-Díaz O, Gracia-Romero A, Rezzouk FZ, Segarra J, Buchaillot ML, Chang-Espino M, Vatter T, Sanchez-Bragado R, Fernandez-Gallego JA, Serret MD, Bort J (2022) Crop phenotyping in a context of global change: what to measure and how to do it. 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+ + 1573-7438 + + 55 + 2 + + 2023 + Mar + 14 + + + Tropical animal health and production + Trop Anim Health Prod + + Antioxidant action of yerba mate on carcass and meat characteristics and fatty acid profile in meat and fat of lambs finished in tropical pastures. + + 109 + + 10.1007/s11250-023-03521-7 + + The objective was to evaluate the effect of the supplementation with natural antioxidants from Yerba mate (Ilex paraguariensis St. Hil.) on the performance, carcass and meat characteristics, and fatty acid profile in meat and fat of Texel × Ile de France lambs kept in Brachiaria-grass pasture. Twenty lambs with a mean age of 90 days and 26.3 kg of BW were distributed in a completely randomized design in two treatments with 10 replicates/treatment: Control-protein-energy supplement based on corn and soybean meal (150 g/kg DM of crude protein) without the addition of natural antioxidant yerba mate and Yerba Mate - energy protein supplement with the addition of yerba mate (110 g/kg DM). There was no treatment effect on animal performance and carcass characteristics. The subcutaneous fat thickness was significantly higher for lambs treated without yerba mate. There was no effect of nutritional treatments on the oxidative markers of lamb meat. The muscle of the animals treated with yerba mate showed a higher concentration of unsaturated and polyunsaturated fatty acids elaidic, linolenic, thymnodonic, docosadienoic, and ceorvonic. The fat of the animals treated with yerba mate showed a higher concentration of palmitoleic acid, linoelaidic acid, heneicosanoic acid, dihomo-γ-linolenic acid, and arachidonic acid. The concentration of polyunsaturated fatty acids was significantly higher in meat and fat of lambs treated with yerba mate. Including yerba mate in the diet of lambs kept on Brachiaria pastures improves the lipid profile of polyunsaturated fatty acids in meat and fat, without altering the performance of the animals. + © 2023. The Author(s), under exclusive licence to Springer Nature B.V. + + + + Baerley + Vinicius Roa + VR + + College of Veterinary Medicine and Animal Science, Federal University of Mato Grosso Do Sul, Campo Grande, MS, Brazil. + + + + Itavo + Camila Celeste Brandão Ferreira + CCBF + + College of Veterinary Medicine and Animal Science, Federal University of Mato Grosso Do Sul, Campo Grande, MS, Brazil. + + + + Itavo + Luis Carlos Vinhas + LCV + + College of Veterinary Medicine and Animal Science, Federal University of Mato Grosso Do Sul, Campo Grande, MS, Brazil. luis.itavo@ufms.br. + + + + Nazário + Carlos Eduardo Domingues + CED + + Institute of Chemistry, Federal University of Mato Grosso Do Sul, Campo Grande, MS, Brazil. + + + + de Nadai Bonin Gomes + Marina + M + + College of Veterinary Medicine and Animal Science, Federal University of Mato Grosso Do Sul, Campo Grande, MS, Brazil. + + + + Dos Santos Difante + Gelson + G + + College of Veterinary Medicine and Animal Science, Federal University of Mato Grosso Do Sul, Campo Grande, MS, Brazil. + + + + Dos Santos + Geraldo Tadeu + GT + + College of Veterinary Medicine and Animal Science, Federal University of Mato Grosso Do Sul, Campo Grande, MS, Brazil. + + + + de Melo + Gleice Kelli Ayardes + GKA + + College of Veterinary Medicine and Animal Science, Federal University of Mato Grosso Do Sul, Campo Grande, MS, Brazil. + + + + Gurgel + Antonio Leandro Chaves + ALC + http://orcid.org/0000-0001-5911-369X + + Department Animal Science, State University of Maringá, Maringá, PR, Brasil. + + + + de Melo Soares + Évelyn Silva + ÉS + + College of Veterinary Medicine and Animal Science, Federal University of Mato Grosso Do Sul, Campo Grande, MS, Brazil. + + + + de Souza Arco + Thais Fernanda Farias + TFF + + College of Veterinary Medicine and Animal Science, Federal University of Mato Grosso Do Sul, Campo Grande, MS, Brazil. + + + + de Godoy + Camila + C + + College of Veterinary Medicine and Animal Science, Federal University of Mato Grosso Do Sul, Campo Grande, MS, Brazil. + + + + da Silva Miguel + Aline Aparecida + AA + + College of Veterinary Medicine and Animal Science, Federal University of Mato Grosso Do Sul, Campo Grande, MS, Brazil. + + + + de Andrade + Priscila Bernardo + PB + + College of Veterinary Medicine and Animal Science, Federal University of Mato Grosso Do Sul, Campo Grande, MS, Brazil. + + + + eng + + + 001 + Coordenação de Aperfeiçoamento de Pessoal de Nível Superior + + + + 001 + Coordenação de Aperfeiçoamento de Pessoal de Nível Superior + + + + 001 + Coordenação de Aperfeiçoamento de Pessoal de Nível Superior + + + + 001 + Coordenação de Aperfeiçoamento de Pessoal de Nível Superior + + + + 001 + Coordenação de Aperfeiçoamento de Pessoal de Nível Superior + + + + 150305/2022-2 + Conselho Nacional de Desenvolvimento Científico e Tecnológico + + + + + Journal Article + + + 2023 + 03 + 14 + +
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+ + + 36917309 + + 2023 + 03 + 14 + +
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+ + + 36917305 + + 2023 + 03 + 14 + +
+ + 1617-7940 + + + 2023 + Mar + 14 + + + Biomechanics and modeling in mechanobiology + Biomech Model Mechanobiol + + A multiscale framework for defining homeostasis in distal vascular trees: applications to the pulmonary circulation. + 10.1007/s10237-023-01693-7 + + Pulmonary arteries constitute a low-pressure network of vessels, often characterized as a bifurcating tree with heterogeneous vessel mechanics. Understanding the vascular complexity and establishing homeostasis is important to study diseases such as pulmonary arterial hypertension (PAH). The onset and early progression of PAH can be traced to changes in the morphometry and structure of the distal vasculature. Coupling hemodynamics with vessel wall growth and remodeling (G&R) is crucial for understanding pathology at distal vasculature. Accordingly, the goal of this study is to provide a multiscale modeling framework that embeds the essential features of arterial wall constituents coupled with the hemodynamics within an arterial network characterized by an extension of Murray's law. This framework will be used to establish the homeostatic baseline characteristics of a pulmonary arterial tree, including important parameters such as vessel radius, wall thickness and shear stress. To define the vascular homeostasis and hemodynamics in the tree, we consider two timescales: a cardiac cycle and a longer period of vascular adaptations. An iterative homeostatic optimization, which integrates a metabolic cost function minimization, the stress equilibrium, and hemodynamics, is performed at the slow timescale. In the fast timescale, the pulsatile blood flow dynamics is described by a Womersley's deformable wall analytical solution. Illustrative examples for symmetric and asymmetric trees are presented that provide baseline characteristics for the normal pulmonary arterial vasculature. The results are compared with diverse literature data on morphometry, structure, and mechanics of pulmonary arteries. The developed framework demonstrates a potential for advanced parametric studies and future G&R and hemodynamics modeling of PAH. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Gharahi + Hamidreza + H + + Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI, USA. gharahih@med.umich.edu. + + + + Filonova + Vasilina + V + + Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI, USA. + + + + Mullagura + Haritha N + HN + + Department of Mechanical Engineering, Michigan State University, East Lansing, MI, USA. + + + + Nama + Nitesh + N + + Department of Mechanical & Materials Engineering, University of Nebraska-Lincoln, Lincoln, NE, USA. + + + + Baek + Seungik + S + + Department of Mechanical Engineering, Michigan State University, East Lansing, MI, USA. + + + + Figueroa + C Alberto + CA + + Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI, USA. + + + Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA. + + + + eng + + + U01-HL135842 + NH + NIH HHS + United States + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Biomech Model Mechanobiol + 101135325 + 1617-7940 + + IM + + Growth and remodeling + Homeostatic optimization + Vasculature morphometry + +
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In: Epstein MAF, Ligas JR (eds) Respiratory biomechanics: engineering analysis of structure and function. Springer-Verlag, New York + + + Zambrano BA, McLean NA, Zhao X et al (2018) Image-based computational assessment of vascular wall mechanics and hemodynamics in pulmonary arterial hypertension patients. J Biomech 68:84–92. https://doi.org/10.1016/j.jbiomech.2017.12.022 + + 10.1016/j.jbiomech.2017.12.022 + + + + +
+ + + 36917299 + + 2023 + 03 + 14 + +
+ + 1573-2789 + + + 2023 + Mar + 14 + + + Community mental health journal + Community Ment Health J + + A 5-Year Suicide Rate of Adolescents Who Enrolled to an Open Dialogue-Based Services: A Nationwide Longitudinal Register-Based Comparison. + 10.1007/s10597-023-01106-0 + + In the Open Dialogue (OD) based psychiatric services adolescent patients receive less medication and are more often treated within an outpatient setting as compared to standard services. An evaluation of the possible risks of implementing OD are required. The aim of this longitudinal register-based study was to evaluate how treatment under OD is associated with the probability of suicide as compared standard psychiatric care. Study included all 13- to 20-year-old adolescents who enrolled to a psychiatric service in Finland in 2003-2013. The OD-group included adolescents whose treatment commenced in the Western Lapland area (n = 2107), this being the only region where OD covered all psychiatric services. The comparison group (CG) included rest of Finland (n = 121,658). Information was gathered from onset of treatment to the end of the 5-year follow-up or death. In a multivariate Cox regression there were no statistically significant differences in 5-year suicide hazard ratios between OD and CG. + © 2023. The Author(s). + + + + Bergström + Tomi + T + http://orcid.org/0000-0002-8300-3113 + + Department of Psychology, University of Jyväskylä, Jyvaskyla, Finland. tomi.s.bergstrom@jyu.fi. + + + Department of Psychiatry, Wellbeing service county of Lapland, Kemi, Finland. tomi.s.bergstrom@jyu.fi. + + + + Seikkula + Jaakko + J + + Department of Psychology, University of Jyväskylä, Jyvaskyla, Finland. + + + Faculty of Health and Sport, University of Agder, Kristiansand, Norway. + + + + Gaily-Luoma + Selma + S + + Department of Psychology, University of Jyväskylä, Jyvaskyla, Finland. + + + + Miettunen + Jouko + J + + Center for Life Course Health Research, University of Oulu, Oulu, Finland. + + + Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland. + + + + Kurtti + Mia + M + + Faculty of Social Sciences, University of Helsinki, Helsinki, Finland. + + + + eng + + + VTR + Sosiaali- ja Terveysministeriö + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Community Ment Health J + 0005735 + 0010-3853 + + IM + + Child and adolescent psychiatry + Family therapy + Mental health services + Mortality + Need-adapted approach + +
+ + + + 2022 + 10 + 16 + + + 2023 + 02 + 23 + + + 2023 + 3 + 14 + 12 + 16 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917299 + 10.1007/s10597-023-01106-0 + 10.1007/s10597-023-01106-0 + + + + Babyak, M. A. (2009). Understanding confounding and mediation. Evidence-based Mental Health, 12(3), 68–71. https://doi.org/10.1136/ebmh.12.3.68 + + 10.1136/ebmh.12.3.68 + 19633239 + + + + Bergström, T. (2020). Rakenteelliset tekijät mutkistavat väestösuhteutettujen mielenterveysindikaattorien tulkintaa. Finnish Medical Journal, 75(40), 2052–2053. + + + Bergström, T., Seikkula, J., Alakare, B., Mäki, P., Köngäs-Saviaro, P., Taskila, J. J., Tolvanen, A., & Aaltonen, J. (2018). The family-oriented open dialogue approach in the treatment of first-episode psychosis: Nineteen-year outcomes. Psychiatry Research, 270, 168–175. https://doi.org/10.1016/j.psychres.2018.09.039 + + 10.1016/j.psychres.2018.09.039 + 30253321 + + + + Bergström, T., Seikkula, J., Alakare, B., Kurtti, M., Köngäs-Saviaro, P., Löhönen, E., Miettunen, J., Mäkiollitervo, H., Taskila, J. J., Virta, K., & Valtanen, K. (2022). The 10-year treatment outcome of open dialogue-based psychiatric services for adolescents: A nationwide longitudinal register-based study. Early Intervention in Psychiatry, 16(12), 1368–1375. https://doi.org/10.1111/eip.13286 + + 10.1111/eip.13286 + 35332989 + + + + Bergström, T., Seikkula, J., Holma, J., Köngäs-Saviaro, P., Taskila, J. J., & Alakare, B. (2022). Retrospective experiences of first-episode psychosis treatment under open dialogue-based services: A qualitative study. Community Mental Health Journal, 58(5), 887–894. https://doi.org/10.1007/s10597-021-00895-6 + + 10.1007/s10597-021-00895-6 + 34550512 + + + + Bergström, T., Seikkula, J., Köngäs-Saviaro, P., Taskila, J. J., & Aaltonen, J. (2022). Need adapted use of medication in the open dialogue approach for psychosis: A descriptive longitudinal cohort study. Psychosis. https://doi.org/10.1080/17522439.2022.2134444 + + 10.1080/17522439.2022.2134444 + + + + Bilsen, J. (2018). Suicide and youth: Risk factors. Frontiers in Psychiatry, 9, 540. https://doi.org/10.3389/fpsyt.2018.00540 + + 10.3389/fpsyt.2018.00540 + 30425663 + 6218408 + + + + Buus, N., Jacobsen, K., Bojesen, E., Bikic, A. B., Müller-Nielsen, A., Aagaard, K., & Erlangsen, A. (2019). The association between open dialogue to young Danes in acute psychiatric crisis and their use of health care and social services: A retrospective register-based cohort study. International Journal of Nursing Studies, 91, 119–127. https://doi.org/10.1016/j.ijnurstu.2018.12.015 + + 10.1016/j.ijnurstu.2018.12.015 + 30682632 + + + + Kiviniemi, M. (2014). Mortality, disability, psychiatric treatment and medication in first-onset schizophrenia in Finland: The register linkage study. Universitatis Ouluensis 2014;D 1267. + + + Lahti, A., Harju, A., Hakko, H., Riala, K., & Räsänen, P. (2014). Suicide in children and young adolescents: A 25-year database on suicides from Northern Finland. Journal of Psychiatric Research, 58, 123–128. https://doi.org/10.1016/j.jpsychires.2014.07.020 + + 10.1016/j.jpsychires.2014.07.020 + 25124549 + + + + Lahti, R. A., & Penttilä, A. (2001). The validity of death certificates: Routine validation of death certification and its effects on mortality statistics. Forensic Science International, 115(1–2), 15–32. https://doi.org/10.1016/s0379-0738(00)00300-5 + + 10.1016/s0379-0738(00)00300-5 + 11056267 + + + + Olson, M., Seikkula, J., & Ziedonis, D. (2014). The key elements of dialogic practice in open dialogue: Fidelity criteria. The University of Massachusetts Medical School. + + + Partonen, T., Eklin, A., Grainger, M., Kauppila, R., Suvisaari, J., & Virtanen, A. (2020). Itsemurhakuolemat Suomessa 2016–2018 Terveyden ja hyvinvoinnin laitos 3/2020. + + + Partonen, T., Grainger, M., Kiviruusu, O., & Suvisaari, J. (2022). Viimeinen terveydenhuollon käynti ennen itsemurhaa vuosina 2016–2018. Duodecim; Laaketieteellinen Aikakauskirja, 138(4), 345–352. + + + Pirkola, S., Sund, R., Sailas, E., & Wahlbeck, K. (2009). Community mental-health services and suicide rate in Finland: A nationwide small-area analysis. Lancet (London England), 373(9658), 147–153. https://doi.org/10.1016/S0140-6736(08)61848-6 + + 10.1016/S0140-6736(08)61848-6 + 19097638 + + + + Razzaque, R., & Stockmann, T. (2016). An introduction to peer-supported open dialogue in mental healthcare. BJPsych Advances, 22(5), 348–356. https://doi.org/10.1192/apt.bp.115.015230 + + 10.1192/apt.bp.115.015230 + + + + Seikkula, J., Alakare, B., & Aaltonen, J. (2011). The Comprehensive open-dialogue Approach in Western Lapland: II. Long-term stability of acute psychosis outcomes in advanced community care. Psychosis, 3(3), 192–204. + + 10.1080/17522439.2011.595819 + + + + Sund, R. (2012). Quality of the Finnish Hospital Discharge Register: A systematic review. Scandinavian Journal of Public Health, 40(6), 505–515. https://doi.org/10.1177/1403494812456637 + + 10.1177/1403494812456637 + 22899561 + + + + The Finnish Institute for Health and Welfare (THL): Statistics and indicator bank.Retrieved April10, 2022 from sotkanet.fi. + + + von Peter, S., Aderhold, V., Cubellis, L., Bergström, T., Stastny, P., Seikkula, J., & Puras, D. (2019). Open dialogue as a Human Rights-Aligned Approach. Frontiers in Psychiatry, 10, 387. https://doi.org/10.3389/fpsyt.2019.00387 + + 10.3389/fpsyt.2019.00387 + + + + +
+ + + 36917310 + + 2023 + 03 + 14 + +
+ + 1573-2800 + + + 2023 + Mar + 14 + + + Archives of sexual behavior + Arch Sex Behav + + Pathways from Polyvictimization to Offline and Online Sexual Harassment Victimization Among South Korean Adolescents. + 10.1007/s10508-023-02569-8 + + This study aimed to investigate the association between polyvictimization and offline and online sexual harassment and whether the association might be mediated by internalizing problems, low school satisfaction, and dropping out of school. The analytic sample was derived from the Children and Youth Rights Survey in South Korea. It consisted of 6353 adolescents' responses to the sexual harassment question and a set of other questions in the middle and high school questionnaires. The findings showed a direct association between polyvictimization and offline and online sexual harassment. Adolescents who were polyvictimized were more likely to be victims of both forms of sexual harassment. Furthermore, polyvictimization was positively related to dropping out of school, which was positively associated with offline sexual harassment. The findings from the study have significant implications for future research and practice. + © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. + + + + Hong + Jun Sung + JS + http://orcid.org/0000-0003-2816-9900 + + School of Social Work, Wayne State University, 5447 Woodward Avenue, Detroit, MI, 48202, USA. fl4684@wayne.edu. + + + Department of Social Welfare, Ewha Womans University, Seoul, South Korea. fl4684@wayne.edu. + + + + Kim + Jinwon + J + http://orcid.org/0000-0002-2803-2886 + + Department of Social Welfare, Hyupsung University, Hwaseong, South Korea. + + + + Lee + Jeoung Min + JM + http://orcid.org/0000-0002-9478-8016 + + School of Social Work, Wichita State University, Wichita, KS, USA. + + + + Saxon + Shani + S + + School of Social Work, Wayne State University, 5447 Woodward Avenue, Detroit, MI, 48202, USA. + + + + Thornberg + Robert + R + http://orcid.org/0000-0001-9233-3862 + + Department of Behavioural Sciences and Learning, Linköping University, Linköping, Sweden. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Arch Sex Behav + 1273516 + 0004-0002 + + IM + + Internalizing problems + Polyvictimization + School dropout + School satisfaction + Sexual harassment + +
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+ + + 36917311 + + 2023 + 03 + 14 + +
+ + 2629-3277 + + + 2023 + Mar + 14 + + + Stem cell reviews and reports + Stem Cell Rev Rep + + The Regulation of the AMPK/mTOR Axis Mitigates Tendon Stem/Progenitor Cell Senescence and Delays Tendon Aging. + 10.1007/s12015-023-10526-0 + + Age-related tendon disorders are closely linked with tendon stem/progenitor cell (TSPC) senescence. However, the underlying mechanisms of TSPC senescence and promising therapeutic strategies for rejuvenation of TSPC senescence remain unclear. In this study, the senescent state of TSPCs increased with age. It was also verified that the AMPK inhibition/mTOR activation is correlated with the senescent state of TSPCs. Furthermore, a low dose of metformin mitigated TSPC senescence and restored senescence-related functions, including proliferation, colony-forming ability, migration ability and tenogenic differentiation ability at the early stage of aging. The protective effects of metformin on TSPCs were regulated through the AMPK/mTOR axis. An in vivo study showed that metformin treatment postpones tendon aging and enhances AMPK phosphorylation but reduces mTOR phosphorylation in a natural aging rat model. Our study revealed new insight and mechanistic exploration of TSPC senescence and proposed a novel therapeutic treatment for age-related tendon disorders by targeting the AMPK/mTOR axis at the early stage of aging. + © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. + + + + Dai + Guangchun + G + + Department of Orthopaedics, School of Medicine, Zhongda Hospital, Southeast University, NO.87 Ding Jia Qiao, 210009, Nanjing, Jiangsu, PR China. + + + School of Medicine, Southeast University, N0.87 Ding Jia Qiao, 210009, Nanjing, PR China. + + + Trauma Center, Zhongda Hospital, Southeast University, 210009, Nanjing, Jiangsu, PR China. + + + Orthopaedic Trauma Institute (OTI), Southeast University, 210009, Nanjing, Jiangsu, PR China. + + + + Li + Yingjuan + Y + + Department of Geriatrics, School of Medicine, Zhongda Hospital, Southeast University, NO.87 Ding Jia Qiao, Nanjing, PR China. + + + + Zhang + Ming + M + + Department of Orthopaedics, School of Medicine, Zhongda Hospital, Southeast University, NO.87 Ding Jia Qiao, 210009, Nanjing, Jiangsu, PR China. + + + School of Medicine, Southeast University, N0.87 Ding Jia Qiao, 210009, Nanjing, PR China. + + + Trauma Center, Zhongda Hospital, Southeast University, 210009, Nanjing, Jiangsu, PR China. + + + Orthopaedic Trauma Institute (OTI), Southeast University, 210009, Nanjing, Jiangsu, PR China. + + + + Lu + Panpan + P + + Department of Orthopaedics, School of Medicine, Zhongda Hospital, Southeast University, NO.87 Ding Jia Qiao, 210009, Nanjing, Jiangsu, PR China. + + + School of Medicine, Southeast University, N0.87 Ding Jia Qiao, 210009, Nanjing, PR China. + + + Trauma Center, Zhongda Hospital, Southeast University, 210009, Nanjing, Jiangsu, PR China. + + + Orthopaedic Trauma Institute (OTI), Southeast University, 210009, Nanjing, Jiangsu, PR China. + + + + Zhang + Yuanwei + Y + + Department of Orthopaedics, School of Medicine, Zhongda Hospital, Southeast University, NO.87 Ding Jia Qiao, 210009, Nanjing, Jiangsu, PR China. + + + School of Medicine, Southeast University, N0.87 Ding Jia Qiao, 210009, Nanjing, PR China. + + + Trauma Center, Zhongda Hospital, Southeast University, 210009, Nanjing, Jiangsu, PR China. + + + Orthopaedic Trauma Institute (OTI), Southeast University, 210009, Nanjing, Jiangsu, PR China. + + + + Wang + Hao + H + + Department of Orthopaedics, School of Medicine, Zhongda Hospital, Southeast University, NO.87 Ding Jia Qiao, 210009, Nanjing, Jiangsu, PR China. + + + School of Medicine, Southeast University, N0.87 Ding Jia Qiao, 210009, Nanjing, PR China. + + + Trauma Center, Zhongda Hospital, Southeast University, 210009, Nanjing, Jiangsu, PR China. + + + Orthopaedic Trauma Institute (OTI), Southeast University, 210009, Nanjing, Jiangsu, PR China. + + + + Shi + Liu + L + + Department of Orthopaedics, School of Medicine, Zhongda Hospital, Southeast University, NO.87 Ding Jia Qiao, 210009, Nanjing, Jiangsu, PR China. + + + Trauma Center, Zhongda Hospital, Southeast University, 210009, Nanjing, Jiangsu, PR China. + + + Orthopaedic Trauma Institute (OTI), Southeast University, 210009, Nanjing, Jiangsu, PR China. + + + + Cao + Mumin + M + + Department of Orthopaedics, School of Medicine, Zhongda Hospital, Southeast University, NO.87 Ding Jia Qiao, 210009, Nanjing, Jiangsu, PR China. + + + School of Medicine, Southeast University, N0.87 Ding Jia Qiao, 210009, Nanjing, PR China. + + + Trauma Center, Zhongda Hospital, Southeast University, 210009, Nanjing, Jiangsu, PR China. + + + Orthopaedic Trauma Institute (OTI), Southeast University, 210009, Nanjing, Jiangsu, PR China. + + + + Shen + Renwang + R + + Department of Orthopaedics, School of Medicine, Zhongda Hospital, Southeast University, NO.87 Ding Jia Qiao, 210009, Nanjing, Jiangsu, PR China. + + + School of Medicine, Southeast University, N0.87 Ding Jia Qiao, 210009, Nanjing, PR China. + + + Trauma Center, Zhongda Hospital, Southeast University, 210009, Nanjing, Jiangsu, PR China. + + + Orthopaedic Trauma Institute (OTI), Southeast University, 210009, Nanjing, Jiangsu, PR China. + + + + Rui + Yunfeng + Y + http://orcid.org/0000-0001-9019-5531 + + Department of Orthopaedics, School of Medicine, Zhongda Hospital, Southeast University, NO.87 Ding Jia Qiao, 210009, Nanjing, Jiangsu, PR China. ruiyunfeng@126.com. + + + Trauma Center, Zhongda Hospital, Southeast University, 210009, Nanjing, Jiangsu, PR China. ruiyunfeng@126.com. + + + Orthopaedic Trauma Institute (OTI), Southeast University, 210009, Nanjing, Jiangsu, PR China. ruiyunfeng@126.com. + + + China Orthopedic Regenerative Medicine Group, 310000, Hangzhou, Zhejiang, PR China. ruiyunfeng@126.com. + + + + eng + + + 81871812 + National Natural Science Foundation of China + + + + 81572187 + National Natural Science Foundation of China + + + + BK20221462 + Natural Science Foundation of Jiangsu Province + + + + BK2012334 + Natural Science Foundation of Jiangsu Province for Young Scholars + + + + ZDRCA2016083 + Jiangsu Provincial Medical Talent; The Project of Invigorating Health Care through Science, Technology and Education + + + + LGY2017099 + The Six Projects Sponsoring Talent Summits of Jiangsu Province, China + + + + + Journal Article + + + 2023 + 03 + 14 + +
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+ + + 36917312 + + 2023 + 03 + 14 + +
+ + 2629-3277 + + + 2023 + Mar + 14 + + + Stem cell reviews and reports + Stem Cell Rev Rep + + Research Progress on the Osteogenesis-Related Regulatory Mechanisms of Human Umbilical Cord Mesenchymal Stem Cells. + 10.1007/s12015-023-10521-5 + + In recent years, research on human umbilical cord mesenchymal stem cells (hUCMSCs) derived from human umbilical cord tissue has accelerated and entered clinical application research. Compared with mesenchymal stem cells (MSCs) from other sources, hUCMSCs can be extracted from different parts of umbilical cord or from the whole umbilical cord. It has the characteristics of less ethical controversy, high differentiation potential, strong proliferation ability, efficient expansion in vitro, avoiding immune rejection and immune privilege, and avoids the limitations of lack of embryonic stem cells, heterogeneity, ethical and moral constraints. hUCMSCs avoid the need for embryonic stem cell sources, heterogeneity, and ethical and moral constraints. Bone defects are very common in clinical practice, but completely effective bone tissue regeneration treatment is challenging. Currently, autologous bone transplantation and allogeneic bone transplantation are main treatment approaches in clinical work, but each has different shortcomings, such as limited sources, invasiveness, immune rejection and insufficient osteogenic ability. Therefore, to solve the bottleneck of bone tissue regeneration and repair, a great amount of research has been carried out to explore the clinical advantages of hUCMSCs as seed cells to promote osteogenesis.However, the regulation of osteogenic differentiation of hUCMSCs is an extremely complex process. Although a large number of studies have demonstrated that the role of hUCMSCs in enhancing local bone regeneration and repair through osteogenic differentiation and transplantation into the body involves multiple signaling pathways, there is no relevant article that summarize the findings. This article discusses the osteogenesis-related regulatory mechanisms of hUCMSCs, summarizes the currently known related mechanisms, and speculates on the possible signals. + © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. + + + + Hu + Zhengqi + Z + http://orcid.org/0000-0003-0246-272X + + Department of Periodontology, Hospital of Stomatology, Zunyi Medical University, Zunyi, 563000, Guizhou, China. + + + + Jiang + Zhiliang + Z + http://orcid.org/0000-0001-9861-7815 + + Department of Periodontology, Hospital of Stomatology, Zunyi Medical University, Zunyi, 563000, Guizhou, China. + + + + Meng + Shengzi + S + http://orcid.org/0000-0003-1727-254X + + Department of Periodontology, Hospital of Stomatology, Zunyi Medical University, Zunyi, 563000, Guizhou, China. + + + + Liu + Rong + R + http://orcid.org/0000-0002-6316-3160 + + Department of Periodontology, Hospital of Stomatology, Zunyi Medical University, Zunyi, 563000, Guizhou, China. + + + + Yang + Kun + K + http://orcid.org/0000-0002-7720-8681 + + Department of Periodontology, Hospital of Stomatology, Zunyi Medical University, Zunyi, 563000, Guizhou, China. Yookun@qq.com. + + + + eng + + + No. [2020]1Y328 (to YK) + Science and Technology Program of Guizhou Province + + + + (gzwkj2022-169) + Health Commission of Guizhou Province + + + + + Journal Article + Review + + + 2023 + 03 + 14 + +
+ + United States + Stem Cell Rev Rep + 101752767 + 2629-3277 + + IM + + Molecular mechanism + OC differentiation + Regeneration and repair + Signaling pathway + Tissue engineering + hUCMSCs + +
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+ + + 36917313 + + 2023 + 03 + 14 + +
+ + 1573-2568 + + + 2023 + Mar + 14 + + + Digestive diseases and sciences + Dig Dis Sci + + Predictive Model for Positive Video Capsule Endoscopy in Iron Deficiency Anemia. + 10.1007/s10620-023-07918-0 + + Bleeding from the gastrointestinal tract can contribute to the development of iron deficiency anemia (IDA) among individuals without another obvious source of bleeding. In order to identify patients most likely to benefit from examination of the small bowel, our aim was to create a risk score for positive video capsule endoscopy (VCE) in IDA utilizing a multicenter collection of studies. + We performed a retrospective multicenter study utilizing VCE studies performed for an indication of IDA between 1/1/2005 and 7/31/2018. VCE findings were graded based on the P0-P2 grading system. The primary outcome of interest was a positive (P2) VCE. Data were analyzed with Student's t test for continuous variables and the Fisher's exact test for categorical variables. Logistic regression was used to identify independent associations with positive VCE. + In total, 765 VCE procedures were included with 355 (46.5%) male subjects and a median age of 63.2 (SD 15.3) years. One hundred ninety studies (24.8%) were positive (P2) for small bowel bleeding. Four variables associated with positive VCE which were incorporated into a point scoring system: (+) 1 for age ≥ 66 years, active smoking and cardiac arrythmia and (-) 1 for preceding hemoglobin level ≥ 8.5. The risk probabilities for positive VCE-assigned scores - 1, 0, 1, and 2 + were 12.3% (95% CI 7.3-17.3%), 20% (14.9-25.1%), 34.8% (28.6-41%), and 39% (30-47.8%). + In order to improve the diagnostic yield of capsule examinations, risk factors should be applied to clinical decision-making. We created a risk score for positive VCE in IDA, including the risk factors of age, smoking, history of cardiac arrythmia, and preceding hemoglobin level. + © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. + + + + Hamdeh + Shadi + S + + Department of Internal Medicine, Division of Gastroenterology, Hepatology and Motility, University of Kansas Medical Center, Kansas City, KS, USA. + + + + Fathallah + Jihan + J + + Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA. + + + + Zhang + Hui + H + + The Center for Health and the Social Sciences, University of Chicago, Chicago, IL, USA. + + + + Charoen + Amber + A + + Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, John Hopkins University School of Medicine, Baltimore, MD, USA. + + + + Altamimi + Barakat Aburajab + BA + + Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Iowa Hospital and Clinics, Iowa City, IA, USA. + + + + Odufalu + Florence-Damilola + FD + + Department of Internal Medicine, Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, Saint Louis, MO, USA. + + + + Dave + Devashree + D + + Department of Internal Medicine, University of Iowa Hospital and Clinics, Iowa City, IA, USA. + + + + Sayed + Amer El + AE + + Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Iowa Hospital and Clinics, Iowa City, IA, USA. + + + + Glick + Laura R + LR + + Department of Internal Medicine, Section of Gastroenterology, Hepatology and Nutrition, University of Chicago Medicine, 5841 South Maryland Avenue, MC4076, Chicago, IL, 60637, USA. + + + + Grisolano + Scott + S + + Department of Internal Medicine, Division of Gastroenterology, Hepatology and Motility, University of Kansas Medical Center, Kansas City, KS, USA. + + + + Hachem + Christine + C + + Department of Internal Medicine, Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, Saint Louis, MO, USA. + + + + Hammami + Muhammad Bader + MB + + Department of Internal Medicine, Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, Saint Louis, MO, USA. + + + + Mahmoud + Khaldoun Haj + KH + + Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA. + + + + Levy + Alexander N + AN + + Division of Gastroenterology and Hepatology, Tufts Medical Center, Boston, MA, USA. + + + + Rao + Vijaya L + VL + + Department of Internal Medicine, Section of Gastroenterology, Hepatology and Nutrition, University of Chicago Medicine, 5841 South Maryland Avenue, MC4076, Chicago, IL, 60637, USA. + + + + Shim + Hong Gi + HG + + Division of Gastroenterology and Hepatology, Tufts Medical Center, Boston, MA, USA. + + + + Semrad + Carol + C + + Department of Internal Medicine, Section of Gastroenterology, Hepatology and Nutrition, University of Chicago Medicine, 5841 South Maryland Avenue, MC4076, Chicago, IL, 60637, USA. + + + + Olyaee + Mojtaba + M + + Department of Internal Medicine, Division of Gastroenterology, Hepatology and Motility, University of Kansas Medical Center, Kansas City, KS, USA. + + + + Micic + Dejan + D + http://orcid.org/0000-0003-2864-1670 + + Department of Internal Medicine, Section of Gastroenterology, Hepatology and Nutrition, University of Chicago Medicine, 5841 South Maryland Avenue, MC4076, Chicago, IL, 60637, USA. dmicic@bsd.uchicago.edu. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Dig Dis Sci + 7902782 + 0163-2116 + + IM + + Gastrointestinal bleeding + Iron deficiency anemia + Small bowel bleeding + Video capsule endoscopy + +
+ + + + 2023 + 02 + 05 + + + 2023 + 03 + 06 + + + 2023 + 3 + 14 + 12 + 16 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917313 + 10.1007/s10620-023-07918-0 + 10.1007/s10620-023-07918-0 + + + + Looker AC, Dallman PR, Carroll MD, Gunter EW, Johnson CL. Prevalence of iron deficiency in the United States. JAMA. 1997;277:973–976. + + 10.1001/jama.1997.03540360041028 + 9091669 + + + + Rockey DC, Cello JP. Evaluation of the gastrointestinal tract in patients with iron-deficiency anemia. N Engl J Med. 1993;329:1691–1695. + + 10.1056/NEJM199312023292303 + 8179652 + + + + Cook IJ, Pavli P, Riley JW, Goulston KJ, Dent OF. Gastrointestinal investigation of iron deficiency anaemia. Br Med J (Clin Res Ed). 1986;292:1380–1382. + + 10.1136/bmj.292.6532.1380 + 3085856 + + + + Kepczyk T, Kadakia SC. Prospective evaluation of gastrointestinal tract in patients with iron-deficiency anemia. 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Artificial intelligence research and development for application in video capsule endoscopy. Gastrointest Endosc Clin North Am. 2021;31(2):387–397. + + 10.1016/j.giec.2020.12.009 + + + + +
+ + + 36917315 + + 2023 + 03 + 14 + +
+ + 1436-5073 + + 190 + 4 + + 2023 + Mar + 14 + + + Mikrochimica acta + Mikrochim Acta + + Decoration of alkalization-intercalated Ti3C2 with ZIF-8@ZIF-67-derived N-doped carbon nanocage for detecting 4-nitrophenol. + + 133 + + 10.1007/s00604-023-05713-2 + + The highly effective alk-Ti3C2/bimetallic Co, Zn embedded N-doped carbon (Co-Zn-NC) composite was fabricated by a convenient self-assembled method strategy and applied to  the reduction of 4-nitrophenol(4-NP). Co-Zn-NC nanocage was synthesized by using designed core-shell ZIF-8@ZIF-67 as sacrificial template. The Co-Zn-NC was prepared by pyrolysis of ZIF-8@ZIF-67 at 900 °C with high-specific surface area and hollow structure, which facilitates the dispersion of Co species and produces abundant Co-Nx active sites. In addition, the electrochemical property and specific surface area of Ti3C2 were improved by alkaline treatment. As a result, compared with alk-Ti3C2 and Co-Zn-NC, the alk-Ti3C2/Co-Zn-NC sensor showed higher activity and stability in detecting 4-NP. The alk-Ti3C2/Co-Zn-NC sensor has a wide determination range of 2-500 μM and a low detection limit of 0.23 μM for 4-NP. In addition, the newly developed alk-Ti3C2/Co-Zn-NC sensor displayed satisfactory reproducibility and  good stability in detecting 4-NP in aqueous samples. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature. + + + + Liu + Qiangbing + Q + + School of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, China. + + + + Liu + Zhenhua + Z + + School of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, China. + + + + Zhang + Jianghua + J + + School of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, China. + + + + Yu + Jingang + J + + School of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, China. + + + + Jiang + Xinyu + X + http://orcid.org/0000-0002-3680-476X + + School of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, China. jiangxinyu@csu.edu.cn. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
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+ + 1420-9071 + + 80 + 4 + + 2023 + Mar + 14 + + + Cellular and molecular life sciences : CMLS + Cell Mol Life Sci + + Brain washing and neural health: role of age, sleep, and the cerebrospinal fluid melatonin rhythm. + + 88 + + 10.1007/s00018-023-04736-5 + + The brain lacks a classic lymphatic drainage system. How it is cleansed of damaged proteins, cellular debris, and molecular by-products has remained a mystery for decades. Recent discoveries have identified a hybrid system that includes cerebrospinal fluid (CSF)-filled perivascular spaces and classic lymph vessels in the dural covering of the brain and spinal cord that functionally cooperate to remove toxic and non-functional trash from the brain. These two components functioning together are referred to as the glymphatic system. We propose that the high levels of melatonin secreted by the pineal gland directly into the CSF play a role in flushing pathological molecules such as amyloid-β peptide (Aβ) from the brain via this network. Melatonin is a sleep-promoting agent, with waste clearance from the CNS being highest especially during slow wave sleep. Melatonin is also a potent and versatile antioxidant that prevents neural accumulation of oxidatively-damaged molecules which contribute to neurological decline. Due to its feedback actions on the suprachiasmatic nucleus, CSF melatonin rhythm functions to maintain optimal circadian rhythmicity, which is also critical for preserving neurocognitive health. Melatonin levels drop dramatically in the frail aged, potentially contributing to neurological failure and dementia. Melatonin supplementation in animal models of Alzheimer's disease (AD) defers Aβ accumulation, enhances its clearance from the CNS, and prolongs animal survival. In AD patients, preliminary data show that melatonin use reduces neurobehavioral signs such as sundowning. Finally, melatonin controls the mitotic activity of neural stem cells in the subventricular zone, suggesting its involvement in neuronal renewal. + © 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG. + + + + Reiter + Russel J + RJ + + Department of Cell Systems and Anatomy, Long School of Medicine, UT Health San Antonio, San Antonio, TX, 78229, USA. reiter@uthscsa.edu. + + + + Sharma + Ramaswamy + R + http://orcid.org/0000-0003-2346-5305 + + Department of Cell Systems and Anatomy, Long School of Medicine, UT Health San Antonio, San Antonio, TX, 78229, USA. sharmar3@uthscsa.edu. + + + + Cucielo + Maira Smaniotto + MS + + Department of Structural and Functional Biology-IBB/UNESP, Institute of Biosciences of Botucatu, Universidade Estadual Paulista, Botucatu, São Paulo, 18618-689, Brazil. + + + + Tan + Dun Xian + DX + + S.T. Bio-Life, San Antonio, TX, USA. + + + + Rosales-Corral + Sergio + S + + Centro de Investigacion Biomedica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Mexico. + + + + Gancitano + Giuseppe + G + + 1st "Tuscania" Paratrooper Regiment, Italian Ministry of Defense, 57127, Leghorn, Italy. + + + + de Almeida Chuffa + Luiz Gustavo + LG + + Department of Structural and Functional Biology-IBB/UNESP, Institute of Biosciences of Botucatu, Universidade Estadual Paulista, Botucatu, São Paulo, 18618-689, Brazil. + + + + eng + + Journal Article + Review + + + 2023 + 03 + 14 + +
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+ + + 36917319 + + 2023 + 03 + 14 + +
+ + 2731-7153 + + + 2023 + Mar + 14 + + + Orthopadie (Heidelberg, Germany) + Orthopadie (Heidelb) + + [Three-year revision rate of certified centres for joint replacement according to EndoCert : Risk-adjusted analysis of outcome quality and comparison with other quality assurance systems]. + 10.1007/s00132-023-04360-y + + The EndoCert initiative does not yet allow a long-term assessment of outcome quality. The assessment cannot be achieved without cooperation with the German arthroplasty registry (EPRD) and other quality assurance infrastructure, such as the quality assurance system of the nationwide healthcare insurance data for inpatient hospital treatment (QSR) by the German local healthcare fund (AOK). Therefore, the quality of care of all certified centres for joint replacement (EPZ) after primary hip and knee arthroplasty was to be examined for the first time. These data were subsequently compared to the data of the EPRD. + In EPZ that provided care to at least one AOK-insured patient in 2016, the risk-adjusted 3‑year revision rate and the SMR-value (standardised mortality or morbidity ratio), which is the quotient of the observed and expected revision rate, were analysed as markers for the quality of care. Annual hospital volume, type of centre and audit results were examined as possible influencing factors. + In the group comparison, significant differences (p = 0.042) for the SMR value of the 3‑year revision rate were demonstrated for hip arthroplasty with regard to the EPZ type. The annual number of primary hip arthroplasties, however, did not influence the 3‑year revision rate. For knee arthroplasties, no effect of the defined categories on the 3‑year revision rate and its SMR value was observed. The comparison of our 3‑year revision rates with those of the EPRD showed similar results for the hip but indicated significant differences for the knee. + We did not observe a correlation between quality of care and annual hospital volume in certified EPZ. However, different quality assurance procedures can lead to different results with respect to the outcome quality. Therefore, a considerably improved interaction of the German quality systems must be achieved. Participation in the EPRD is not sufficient for this. Rather, a complete report of all arthroplasties must be required, at least with the achievement of a minimum reporting rate per participating hospital. Uniform inclusion and exclusion criteria should be defined. + © 2023. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature. + + + + Osmanski-Zenk + Katrin + K + + Orthopädische Klinik und Poliklinik, Universitätsmedizin Rostock, Doberaner Straße 142, 18057, Rostock, Deutschland. katrin.osmanski-zenk@med.uni-rostock.de. + + + + Klinder + Annett + A + + Orthopädische Klinik und Poliklinik, Universitätsmedizin Rostock, Doberaner Straße 142, 18057, Rostock, Deutschland. + + + + Malzahn + Jürgen + J + + AOK-Bundesverband, Rosenthaler Str. 31, 10178, Berlin, Deutschland. + + + + Haas + Holger + H + + Zentrum für Orthopädie, Unfallchirurgie und Sportmedizin, Gemeinschaftskrankenhaus Bonn, 53113, Bonn, Deutschland. + + + + von Lewinski + Gabriela + G + + Klinik für Unfallchirurgie, Orthopädie und Plastische Chirurgie, Universitätsmedizin Göttingen, Robert-Koch-Straße 40, 37075, Göttingen, Deutschland. + + + + Kladny + Bernd + B + + Fachklinik Herzogenaurach, 91074, Herzogenaurach, Deutschland. + + + + Mittelmeier + Wolfram + W + + Orthopädische Klinik und Poliklinik, Universitätsmedizin Rostock, Doberaner Straße 142, 18057, Rostock, Deutschland. + + + + ger + + English Abstract + Journal Article + + 3-Jahres-Revisionsrate von zertifizierten EndoProthetikZentren nach EndoCert : Risikoadjustierte Analyse der Ergebnisqualität und Vergleich mit anderen Qualitätssicherungssystemen. + + 2023 + 03 + 14 + +
+ + Germany + Orthopadie (Heidelb) + 9918384887206676 + 2731-7145 + + IM + + HINTERGRUND: Eine langfristige Beurteilung der Ergebnisqualität lässt das EndoCert-Verfahren bisher nicht zu und kann ohne Kooperationen mit dem Endoprothesenregister Deutschland (EPRD) oder anderen Qualitätssicherungsverfahren, wie dem Qualitätssicherungssystem mit Routinedaten der AOK (QSR) auch nicht erreicht werden. Es soll erstmalig unter Einbeziehung von QSR-Daten der AOK die Versorgungsqualität aller zertifizierten Zentren (EPZ) nach primärer Hüft- und Knie-TEP (Totalendoprothese) geprüft und mit den Daten des EPRD verglichen werden. + In EPZ, die mindestens eine/-n AOK-Versicherte/-n im Jahr 2016 versorgt haben, wurden die risikoadjustierte 3‑Jahres-Revisionsrate und der SMR-Wert (standardisierte Mortalitäts‑/Morbiditätsratio), welcher der Quotient aus beobachteter und erwarteter Revisionsrate ist, als Marker für die Versorgungsqualität analysiert. Versorgungshäufigkeit, Zentrumsart und Auditergebnisse wurden als Einflussfaktoren untersucht. + Beim Gruppenvergleich wurden für die Hüft-TEP hinsichtlich der EPZ-Art signifikante Unterschiede (p = 0,042) für den SMR-Wert der 3‑Jahres-Revisionsrate nachgewiesen. Die Anzahl der primären Hüft-TEP hatte hingegen keinen Einfluss auf die 3‑Jahres-Revisionsrate. Für die Knie-TEP wurde kein Effekt der definierten Kategorien auf die 3‑Jahres-Revisionsrate und deren SMR-Wert beobachtet. Die Gegenüberstellung unserer 3‑Jahres-Revisionsraten mit denen vom EPRD zeigte vergleichbare Ergebnisse bei Hüft-TEP, jedoch erhebliche Unterschiede bei Knie-TEP. + Wir konnten keinen Zusammenhang zwischen Versorgungsqualität und -häufigkeit in den EPZ nachweisen. Allerdings können unterschiedliche QS-Verfahren zu abweichenden Bewertungen der Ergebnisqualität führen. Eine deutlich bessere Vernetzung der Systeme sollte angestrebt werden. Dafür ist die Teilnahme am EPRD nicht ausreichend. Vielmehr muss eine vollständige Eingabe aller Prothesenversorgungen, zumindest unter Erreichung einer Mindestquote je teilnehmender Klinik, gefordert werden. Einheitliche Ein- und Ausschlusskriterien sollten definiert werden. + + + Annual hospital volume + Certification + Quality assurance, healthcare + Registries + Total hip arthroplasty + Total knee arthroplasty + +
+ + + + 2023 + 01 + 13 + + + 2023 + 3 + 14 + 12 + 17 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917319 + 10.1007/s00132-023-04360-y + 10.1007/s00132-023-04360-y + + + Literatur + + Haas H (Hrsg) (2013) EndoCert: Zertifizierung von endoprothetischen Versorgezentren in Deutschland ; eine Initiative der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie (DGOOC) mit Unterstützung der Arbeitsgemeinschaft Endoprothetik (AE). Thieme, Stuttgart, New York + + + Haas H, Bail HJ, Günther KP, Heller KD, Heppt P, Kladny B, von Lewinski G, Lohmann C‑H, Wirtz DC, Mittelmeier W (2013) Anforderungskatalog für EndoProthetikZentren zur Zertifizierung von EndoProthetikZentren als qualitätssichernde Maßnahme in der Behandlung von Gelenkerkrankungen: EndoProthetikZentrum der Maximalversorgung (EndoCert) (EPZmax). https://www.clarcert.com/_Resources/Persistent/a27ad40d6519fb9aca450ecaf96f4d6981801abb/__anforderungskatalog%20epzmax-L1%20%28210308%29.pdf . Zugegriffen: 6. Mai 2021 + + + Haas H, Bail HJ, Günther KP, Heller KD, Heppt P, Kladny B, von Lewinski G, Lohmann C‑H, Wirtz DC, Mittelmeier W (2013) Anforderungskatalog für EndoProthetikZentren zur Zertifizierung von EndoProthetikZentren als qualitätssichernde Maßnahme in der Behandlung von Gelenkerkrankungen: EndoProthetikZentrum (EndoCert) (EPZ). https://www.clarcert.com/_Resources/Persistent/9831679861a87ccbd7be5e6eefe9b8e4e9df4f01/__anforderungskatalog%20epz-L1%20%28201028%29.pdf . Zugegriffen: 6. Mai 2021 + + + Jansson V, Grimberg A, Melsheimer O, Perka C, Steinbrück A (2019) Orthopaedic registries: the German experience. EFORT Open Rev 4:401–408. https://doi.org/10.1302/2058-5241.4.180064 + + 10.1302/2058-5241.4.180064 + 31210976 + 6549118 + + + + Hey A, Grimberg A, Mühlnikel I, Kleinfeld A (2020) Das Endoprothesenregister Deutschland (EPRD) als Prototyp für das neue staatliche Implantateregister. Barmer + + + Wissenschaftliches Institut der AOK (WIdO) im AOK-Bundesverband GbR Qualitätssicherung mit Routinedaten (QSR) – Klinikbericht über Ergebniskennzahlen: Verfahrensjahr 2021 Berichtsjahr 2017–2019 mit Nachbeobachtung 2020. https://www.qualitaetssicherung-mit-routinedaten.de/imperia/md/qsr/kliniken/qsrklinikbericht_2021_muster.pdf . Zugegriffen: 17. Nov. 2021 + + + EPRD Deutsche Endoprothesenregister (2021) Jahresbericht 2021: Mit Sicherheit mehr Qualität. EPRD Deutsche Endoprothesenregister, Berlin + + + Mittelmeier W, Bail HJ, Günther KP, Heller KD, Heppt P, Wirtz DC, Haas H EndoCert ® Jahresbericht 2020: Zertifizierte EndoProthetikZentren gemäß EndoCert. https://endocert.de/images/pdf/Jahresbericht_EndoCert_2020.pdf . Zugegriffen: 18. Nov. 2021 + + + Wissenschaftliches Institut der AOK QSR-Verfahren Indikatorenhandbuch: Verfahrensjahr 2021. https://www.qualitaetssicherung-mit-routinedaten.de/imperia/md/qsr/methoden/indikatorenhandbuch_2021_final_1.pdf . Zugegriffen: 7. 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Lancet 384:1437–1445. https://doi.org/10.1016/S0140-6736(14)60419-0 + + 10.1016/S0140-6736(14)60419-0 + 25012116 + + + + Jeschke E, Gehrke T, Günster C, Hassenpflug J, Malzahn J, Niethard FU, Schräder P, Zacher J, Halder A (2016) Five-year survival of 20,946 unicondylar knee replacements and patient risk factors for failure: an analysis of German insurance data. J Bone Joint Surg Am 98:1691–1698. https://doi.org/10.2106/JBJS.15.01060 + + 10.2106/JBJS.15.01060 + 27869619 + + + + Bleß H‑H, Kip M (2017) Weißbuch Gelenkersatz. Springer, Berlin, Heidelberg + + 10.1007/978-3-662-53260-7 + + + + +
+ + + 36917321 + + 2023 + 03 + 14 + +
+ + 1432-2307 + + + 2023 + Mar + 14 + + + Virchows Archiv : an international journal of pathology + Virchows Arch + + In this issue. + 10.1007/s00428-023-03528-3 + eng + + News + + + 2023 + 03 + 14 + +
+ + Germany + Virchows Arch + 9423843 + 0945-6317 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 17 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917321 + 10.1007/s00428-023-03528-3 + 10.1007/s00428-023-03528-3 + + +
+ + + 36917327 + + 2023 + 03 + 14 + +
+ + 1612-9067 + + + 2023 + Mar + 14 + + + Esophagus : official journal of the Japan Esophageal Society + Esophagus + + Prognostic impact of desmoplastic reaction in esophageal squamous cell carcinoma patients with neoadjuvant therapy. + 10.1007/s10388-023-00996-z + + This study aimed to examine the prognostic value of desmoplastic reaction (DR) in esophageal squamous cell carcinoma (ESCC), particularly in patients who received neoadjuvant therapy, such as chemotherapy (NAC) or chemoradiotherapy (NACRT). + In total, 153 patients with pStage II/III ESCC were included in this study. Ninety-one patients received neoadjuvant therapy (NAC, 70; NACRT, 21). Patients were classified according to three DR categories based on the presence of keloid-like collagen and/or myxoid stroma. + In total, 50, 50, and 53 patients were classified as having mature, intermediate, and immature DR, respectively. The weighted kappa coefficient was 0.623 in the patients with preoperative treatments and 0.782, in those without. The 5-year disease-specific survival (DSS) rates in patients with intermediate/immature DR was significantly worse than those with mature DR (40.7% vs. 73.3%, p < 0.001). Similarly, the 5-year DSS rate in patients with intermediate/immature DR was significantly worse than those with mature DR in a study of patients who received neoadjuvant therapy (46.7% vs. 71.2%, p = 0.009). Multivariate analysis revealed that DR (hazard ratio [HR]: 3.15, 95% confidence interval [CI] 1.58-6.27, p = 0.001), along with N factors, was an independent risk factor for DSS. Moreover, multivariate analysis of patients who received neoadjuvant therapy revealed only DR (HR: 2.47, 95% CI 1.02-5.96, p = 0.045) as independent risk factors for DSS. + The DR classification was a valuable prognostic factor not only in the ESCC patients without neoadjuvant therapy but also in those with neoadjuvant therapy. + © 2023. The Author(s) under exclusive licence to The Japan Esophageal Society. + + + + Kouzu + Keita + K + + Department of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, Japan. + + + + Kajiwara + Yoshiki + Y + http://orcid.org/0000-0002-9427-2204 + + Department of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, Japan. ykaji@ndmc.ac.jp. + + + + Tsujimoto + Hironori + H + + Department of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, Japan. + + + + Mochizuki + Satsuki + S + + Department of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, Japan. + + + + Okamoto + Koichi + K + + Department of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, Japan. + + + + Shinto + Eiji + E + + Department of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, Japan. + + + + Kishi + Yoji + Y + + Department of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, Japan. + + + + Matsukuma + Susumu + S + + Department of Pathology and Laboratory Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan. + + + + Ueno + Hideki + H + + Department of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, Japan. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Japan + Esophagus + 101206627 + 1612-9059 + + IM + + Desmoplastic reaction + Esophageal cancer + Neoadjuvant chemoradiotherapy + Neoadjuvant chemotherapy + Squamous cell carcinoma + +
+ + + + 2022 + 09 + 27 + + + 2023 + 03 + 03 + + + 2023 + 3 + 14 + 12 + 17 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917327 + 10.1007/s10388-023-00996-z + 10.1007/s10388-023-00996-z + + + + Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68:394–424. + + 10.3322/caac.21492 + 30207593 + + + + Batra R, Malhotra GK, Singh S, et al. Managing squamous cell esophageal cancer. Surg Clin N Am. 2019;99:529–41. + + 10.1016/j.suc.2019.02.006 + 31047040 + + + + Shah MA, Kennedy EB, Catenacci DV, et al. Treatment of locally advanced esophageal carcinoma: ASCO Guideline: ASCO Guideline. J Clin Oncol. 2020;38:2677–94. + + 10.1200/JCO.20.00866 + 32568633 + + + + Kitagawa Y, Uno T, Oyama T, et al. Esophageal cancer practice guidelines 2017 edited by the Japan Esophageal Society: part 1. Esophagus. 2019;16:1–24. + + 10.1007/s10388-018-0641-9 + 30171413 + + + + Kitagawa Y, Uno T, Oyama T, et al. Esophageal cancer practice guidelines 2017 edited by the Japan esophageal society: part 2. Esophagus. 2019;16:25–43. + + 10.1007/s10388-018-0642-8 + 30171414 + + + + Kelly RJ, Ajani JA, Kuzdzal J, et al. Adjuvant nivolumab in resected esophageal or gastroesophageal junction cancer. N Engl J Med. 2021;384:1191–203. + + 10.1056/NEJMoa2032125 + 33789008 + + + + Ueno H, Jones A, Jass JR, et al. Clinicopathological significance of the “keloid-like” collagen and myxoid stroma in advanced rectal cancer. Histopathology. 2002;40:327–34. + + 10.1046/j.1365-2559.2002.01376.x + 11943016 + + + + Ueno H, Kanemitsu Y, Sekine S, et al. Desmoplastic pattern at the tumor front defines poor-prognosis subtypes of colorectal cancer. Am J Surg Pathol. 2017;41:1506–12. + + 10.1097/PAS.0000000000000946 + 28877064 + + + + Ueno H, Sekine S, Oshiro T, et al. 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Gut. 2015;64:381–7. + + 10.1136/gutjnl-2014-308124 + 25320104 + + + + Sakai A, Nakashima Y, Miyashita Y, et al. Histological categorisation of the desmoplastic reaction is a predictor of patient prognosis in oesophageal squamous cell carcinoma. Histopathology. 2021;79:219–26. + + 10.1111/his.14357 + 33595141 + + + + Li ZW, He L, Zheng Z, et al. Combined assessment of tumour cell nest size and desmoplastic reaction as an excellent prognostic predictor in oesophageal squamous cell carcinoma. Histopathology. 2022;80:1112–20. + + 10.1111/his.14657 + 35353393 + + + + Brierley JD, Gospodarowicz MK, Christian W. TNM Classification of Malignant Tumours. 8th ed. New York: Wiley; 2017. + + + Japan Esophageal Society. Japanese Classification of Esophageal Cancer, 11th Edition: part I. Esophagus. 2017;14:1–36. + + 10.1007/s10388-016-0551-7 + + + + Japan Esophageal Society. Japanese Classification of Esophageal Cancer, 11th Edition: part II and III. 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Virchows Arch. 2022;480:793–805. + + 10.1007/s00428-021-03266-4 + 35149891 + + + + Ueno H, Shinto E, Shimazaki H, et al. Histologic categorization of desmoplastic reaction: its relevance to the colorectal cancer microenvironment and prognosis. Ann Surg Oncol. 2015;22:1504–12. + + 10.1245/s10434-014-4149-9 + 25395146 + + + + Ao T, Mochizuki S, Kajiwara Y, et al. Cancer-associated fibroblasts at the unfavorable desmoplastic stroma promote colorectal cancer aggressiveness: potential role of ADAM9. Int J Cancer. 2022;150:1706–21. + + 10.1002/ijc.33947 + 35080810 + + + + Tsutsumi S, Saeki H, Nakashima Y, et al. Programmed death-ligand 1 expression at tumor invasive front is associated with epithelial-mesenchymal transition and poor prognosis in esophageal squamous cell carcinoma. Cancer Sci. 2017;108:1119–27. + + 10.1111/cas.13237 + 28294486 + 5480087 + + + + Chen L, Xiong Y, Li J, et al. PD-L1 expression promotes epithelial to mesenchymal transition in human esophageal cancer. Cell Physiol Biochem. 2017;42:2267–80. + + 10.1159/000480000 + 28848143 + + + + Liu X, He M, Li L, et al. EMT and cancer cell stemness associated With chemotherapeutic resistance in esophageal cancer. Front Oncol. 2021;11: 672222. + + 10.3389/fonc.2021.672222 + 34150636 + 8209423 + + + + Kong D, Long D, Liu B, et al. Downregulation of long non-coding RNA LOC101928477 correlates with tumor progression by regulating the epithelial-mesenchymal transition in esophageal squamous cell carcinoma. Thorac Cancer. 2021;12:1303–11. + + 10.1111/1759-7714.13858 + 33713583 + 8088935 + + + + Michot JM, Bigenwald C, Champiat S, et al. Immune-related adverse events with immune checkpoint blockade: a comprehensive review. Eur J Cancer. 2016;54:139–48. + + 10.1016/j.ejca.2015.11.016 + 26765102 + + + + Verma V, Sprave T, Haque W, et al. A systematic review of the cost and cost-effectiveness studies of immune checkpoint inhibitors. J Immunother Cancer. 2018;6:128. + + 10.1186/s40425-018-0442-7 + 30470252 + 6251215 + + + + +
+ + + 36917317 + + 2023 + 03 + 14 + +
+ + 1435-702X + + + 2023 + Mar + 14 + + + Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie + Graefes Arch Clin Exp Ophthalmol + + Impact of major age-related eye disorders on health-related quality of life assessed by EQ-5D: a systematic review and meta-analysis. + 10.1007/s00417-023-06034-z + + This study is to quantitatively estimate the health-related quality of life (HRQOL) impact of major age-related eye diseases (AREDs) including cataract, glaucoma, age-related macular degeneration (AMD), and diabetic retinopathy (DR) assessed by the EuroQoL Five-Dimensional Questionnaire (EQ-5D). + PubMed, Embase, Cochrane Library, and CINAHL were searched until October 20, 2022. Studies were included if they reported the EQ-5D health utility score (HUS) or visual analogue scale (VAS) score of both AREDs patients and healthy controls. The mean difference (MD) in HUS or VAS score between cases and controls and its 95% confidence interval (95%CI) were pooled using the random-effects model. We also performed sensitivity analysis using the leaving-one-out method and subgroup analyses by sample size and race. The prevalence in reporting any problems in the five EQ-5D dimensions was summarized and compared between cases and controls using the Chi-square test. + Fifteen articles involving 30,491 participants were included in this review. Pooled estimates indicated reduced HUS in AMD patients (MD = - 0.04, 95%CI - 0.07, - 0.01; P = 0.009), DR patients (MD = - 0.03, 95%CI - 0.05, - 0.01; P = 0.01), and glaucoma patients (MD = - 0.06, 95%CI - 0.10, - 0.01; P = 0.01), compared with the controls. Significantly lower EQ-5D VAS score was also observed in cataract patients (MD = - 11.33, 95%CI - 13.47, - 9.18; P < 0.001) and DR patients (MD = - 6.41, 95%CI - 10.64, - 2.18; P = 0.003). AREDs patients reported usual activities and anxiety/depression problems more frequently than the control group. + Our findings confirmed the HRQOL impairment caused by major AREDs including AMD, cataract, DR, and glaucoma. High-quality studies with large sample sizes are warranted to further verify our results. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Kai + Jia-Yan + JY + + School of Public Health, Medical College of Soochow University, 199 Ren Ai Road, Suzhou, 215123, China. + + + + Xu + Yue + Y + + Department of Ophthalmology, Dushu Lake Hospital Affiliated to Soochow University, Suzhou, China. + + + + Li + Dan-Lin + DL + + School of Public Health, Medical College of Soochow University, 199 Ren Ai Road, Suzhou, 215123, China. + + + + Zhou + Miao + M + + Department of Ophthalmology, Peking University People's Hospital, Beijing, China. + + + Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Beijing, China. + + + + Wang + Pei + P + + School of Public Health, Fudan University, 130 Dong An Road, Shanghai, 200032, China. Wang_p@fudan.edu.cn. + + + Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, 130 Dong An Road, Shanghai, 200032, China. Wang_p@fudan.edu.cn. + + + + Pan + Chen-Wei + CW + http://orcid.org/0000-0003-3362-4613 + + School of Public Health, Medical College of Soochow University, 199 Ren Ai Road, Suzhou, 215123, China. pcwonly@gmail.com. + + + + eng + + + 82122059 + National Natural Science Foundation of China + + + + + Journal Article + Review + + + 2023 + 03 + 14 + +
+ + Germany + Graefes Arch Clin Exp Ophthalmol + 8205248 + 0721-832X + + IM + + Age-related macular degeneration + Cataract + Diabetic retinopathy + Glaucoma + Health-related quality of life + Meta-analysis + +
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+ + + 36917320 + + 2023 + 03 + 14 + +
+ + 1573-6792 + + + 2023 + Mar + 14 + + + Brain topography + Brain Topogr + + Event-Related Potentials Index Prediction Error Signalling During Perceptual Processing of Emotional Facial Expressions. + 10.1007/s10548-023-00951-2 + + Humans use socially relevant stimuli to guide perceptual processing of the surrounding environment, with emotional stimuli receiving preferential attention due to their social importance. Predictive coding theory asserts this cognitive process occurs efficiently by combining predictions about what is to be perceived with incoming sensory information, generating prediction errors that are then used to update future predictions. Recent evidence has identified differing neural activity that demonstrates how spatial and feature-based attention may interact with prediction, yet how emotion-guided attention may influence this relationship remains unknown. In the present study, participants viewed a display of two faces in which attention, prediction, and emotion were manipulated, and responded to a face expressing a specific emotion (anger or happiness). The N170 was found to be enhanced by unpredictable as opposed to predictable stimuli, indicating that it indexes general prediction error signalling processes. The N300 amplitudes were also enhanced by unpredictable stimuli, but they were also affected by the attentional status of angry but not happy faces, suggesting that there are differences in prediction error processes indexed by the N170 and N300. Overall, the findings suggest that the N170 and N300 both index violations of expectation for spatial manipulations of stimuli in accordance with prediction error responding processes. + © 2023. The Author(s). + + + + Baker + Kristen S + KS + + Faculty of Health, School of Psychology and Counselling, Queensland University of Technology (QUT), Brisbane, QLD, Australia. + + + + Johnston + Patrick + P + + Defence Science and Technology Group, Information Sciences Division, Eagle Farm, QLD, Australia. + + + + Yamamoto + Naohide + N + + Faculty of Health, School of Psychology and Counselling, Queensland University of Technology (QUT), Brisbane, QLD, Australia. + + + Centre for Vision and Eye Research, Queensland University of Technology (QUT), Brisbane, QLD, Australia. + + + + Pegna + Alan J + AJ + + Laboratory of Cognitive and Experimental Neuropsychology, Faculty of Health and Behavioural Sciences, School of Psychology, The University of Queensland, Brisbane, QLD, Australia. a.pegna@uq.edu.au. + + + + eng + + + Queensland University of Technology + Queensland University of Technology + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Brain Topogr + 8903034 + 0896-0267 + + IM + + Attention + Emotion + N170 + N300 + Prediction + +
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+ + + 36917325 + + 2023 + 03 + 14 + +
+ + 1573-4927 + + + 2023 + Mar + 14 + + + Biochemical genetics + Biochem Genet + + MiR-24-1-5p Hinders Malignant Phenotypes of Clear Cell Renal Cell Carcinoma by Targeting SHOX2. + 10.1007/s10528-023-10353-5 + + MiRNAs are essential epigenetic modulators that can regulate protein expression. According to the principle of base complementary pairing, miRNA is partially or completely complementary to the 3'-UTR region of its target gene, by which it inhibits the translation of the targeted gene. This study investigated the role of miR-24-1-5p in clear cell renal cell carcinoma (ccRCC). Data in TCGA-KIRC denoted that miR-24-1-5p was under-expressed in ccRCC. Bioinformatics analysis predicted that its target gene was SHOX2, which was significantly expressed in cancer tissues. Dual luciferase assay verified the targeting relationship between miR-24-1-5p and SHOX2. Cell function experiments demonstrated that overexpression of miR-24-1-5p significantly inhibited SHOX2 level and the malignant phenotypes of ccRCC cells. The above results illustrated that miR-24-1-5p/SHOX2 axis was critical for the oncogenesis and development of ccRCC, which might be helpful for us to understand the mechanism and novel therapeutic methods of ccRCC. + © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. + + + + Zhou + Jueyi + J + + Department of Oncology, Lishui People's Hospital, The Sixth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China. + + + + Li + Peng + P + + Department of Urology Surgery, Lishui People's Hospital, The Sixth Affiliated Hospital of Wenzhou Medical University, No. 15 Dazhong Street, Liandu District, Lishui, 323000, China. + + + + Feng + Jihong + J + + Department of Oncology, Lishui People's Hospital, The Sixth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China. + + + + Wu + Qi + Q + + Department of Urology Surgery, Lishui People's Hospital, The Sixth Affiliated Hospital of Wenzhou Medical University, No. 15 Dazhong Street, Liandu District, Lishui, 323000, China. + + + + You + Shengjie + S + + Department of Urology Surgery, Lishui People's Hospital, The Sixth Affiliated Hospital of Wenzhou Medical University, No. 15 Dazhong Street, Liandu District, Lishui, 323000, China. yousjjsy@163.com. + + + + eng + + + 2017ZDYF11 + the Key Research and Development Project + + + + 018ZDHZ12 + Zhejiang University Cooperation Project + + + + LGF20H050003 + Zhejiang Public Welfare Technology Application Research Project + + + + 2020382934 + Zhejiang Medical and Health Science and Technology Plan Project + + + + 2020ZB309 + Traditional Chinese medicine of Zhejiang province science and technology plan project + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Biochem Genet + 0126611 + 0006-2928 + + IM + + Invasion + Migration + Proliferation + SHOX2 + ccRCC + miR-24-1-5p + +
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Mol Cancer 18:151. https://doi.org/10.1186/s12943-019-1072-5 + + 10.1186/s12943-019-1072-5 + 31672157 + 6824104 + + + + Yang T et al (2013) Elevated SHOX2 expression is associated with tumor recurrence of hepatocellular carcinoma. Ann Surg Oncol 20(Suppl 3):S644-649. https://doi.org/10.1245/s10434-013-3132-1 + + 10.1245/s10434-013-3132-1 + 23851611 + + + + Yang F et al (2014) LIM and SH3 domain protein 1 (LASP-1) overexpression was associated with aggressive phenotype and poor prognosis in clear cell renal cell cancer. PLoS One 9:e100557. https://doi.org/10.1371/journal.pone.0100557 + + 10.1371/journal.pone.0100557 + 24955835 + 4067378 + + + + Zambrano NR, Lubensky IA, Merino MJ, Linehan WM, Walther MM (1999) Histopathology and molecular genetics of renal tumors toward unification of a classification system. J Urol 162:1246–1258 + + 10.1016/S0022-5347(05)68259-6 + 10492174 + + + + Zhai W et al (2017) LncRNA-SARCC suppresses renal cell carcinoma (RCC) progression via altering the androgen receptor(AR)/miRNA-143-3p signals. Cell Death Differ 24:1502–1517. https://doi.org/10.1038/cdd.2017.74 + + 10.1038/cdd.2017.74 + 28644440 + 5563985 + + + + Zhang W et al (2018) LINC01088 inhibits tumorigenesis of ovarian epithelial cells by targeting miR-24-1-5p. Sci Rep 8:2876. https://doi.org/10.1038/s41598-018-21164-9 + + 10.1038/s41598-018-21164-9 + 29440672 + 5811426 + + + + Zhang H et al (2019) Up-regulation of miR-24-1-5p is involved in the chemoprevention of colorectal cancer by black raspberry anthocyanins. Br J Nutr 122:518–526. https://doi.org/10.1017/S0007114518003136 + + 10.1017/S0007114518003136 + 30375302 + + + + +
+ + + 36917326 + + 2023 + 03 + 14 + +
+ + 1573-6601 + + + 2023 + Mar + 14 + + + Journal of youth and adolescence + J Youth Adolesc + + Correction: Attachment to Peers and School: Longitudinal Moderators of the Relation between Caregiver Psychological Distress and Adolescent Hopelessness. + 10.1007/s10964-023-01759-w + + + Hooper + Lisa M + LM + http://orcid.org/0000-0002-5493-0110 + + University of Northern Iowa, Cedar Falls, IA, USA. lisa.hooper@uni.edu. + + + + Lee + Sei-Young + SY + + University of Northern Iowa, Cedar Falls, IA, USA. + + + + Tomek + Sara + S + + Baylor University, Waco, TX, USA. + + + + Jaggers + Jeremiah W + JW + + University of Utah, Salt Lake City, UT, USA. + + + + Kim + Grace + G + + University of Louisville, Louisville, KY, USA. + + + + Church + Wesley T + WT + 2nd + + Louisiana State University, Baton Rouge, LA, USA. + + + + Bolland + John + J + + Institute for Social Science Research at the University of Alabama, Tuscaloosa, AL, USA. + + + + eng + + Published Erratum + + + 2023 + 03 + 14 + +
+ + United States + J Youth Adolesc + 0333507 + 0047-2891 + + IM + + + J Youth Adolesc. 2021 Jan 15;: + 33449286 + + +
+ + + + 2023 + 3 + 14 + 12 + 17 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917326 + 10.1007/s10964-023-01759-w + 10.1007/s10964-023-01759-w + + +
+ + + 36917322 + + 2023 + 03 + 14 + +
+ + 2197-1153 + + 10 + 1 + + 2023 + Mar + 14 + + + Journal of experimental orthopaedics + J Exp Orthop + + Impacted bone allograft personalised by a novel 3D printed customization kit produces high surgical accuracy in medial opening wedge high tibial osteotomy: a pilot study. + + 24 + + 10.1186/s40634-023-00593-0 + + Contemporary medial opening wedge high tibial osteotomy (MOWHTO) still seems to struggle with inconsistent accuracy outcomes. Our objective was to assess surgical accuracy and short-term clinical outcomes when using 3D planning and a patient-specific instrumentation (PSI) kit to prepare customized bone allografts. + Thirty subjects (age 48y ± 13) were included in a double-center prospective case series. A low-dose CT-scan was performed to generate 3D bone models, a MOWHTO was simulated, and PSI was designed and 3D printed based on the complementary negative of the planned osteotomy gap. Clinical outcome was assessed at two, four, 12 weeks and one year using NRS, KOOS, UCLA activity score, EQ-5D and anchor questions. A linear-mixed model approach was implemented for data analysis. + Preoperative 3D values were 175.0° ± 2.2 mechanical tibiofemoral angle (mTFA), 85.0° ± 3.0 medial proximal tibial angle (MPTA), and 94.1° ± 3.4 medial posterior tibial slope (MPTS). Target planning ranged from slight varus to the lateral tibial spine (slight valgus). Postoperative 3D analysis showed an accuracy of 1.1° ± 0.7 ΔMPTA (p = 0.04) and 1.2° ± 1.2 ΔMPTS (p = 0.11). NRS decreased from baseline 6.1 ± 1.9 to 2.7 ± 1.9 at four weeks (p < 0.001) and 1.7 ± 1.9 at one year (p < 0.001). KOOS increased from 31.4 ± 17.6 to 50.6 ± 20.6 at 12 weeks (p < 0.001) and to 71.8 ± 15.6 at one year (p < 0.001). + The study suggests that 3D printed instrumentation to personalize structural bone allograft is a viable alternative method in MOWHTO that has the benefit of optimizing surgical accuracy while providing early and consistent pain relief after surgery. + © 2023. The Author(s). + + + + Van Genechten + Wouter + W + http://orcid.org/0000-0001-5844-9247 + + Orthopedic Department, University Hospital Antwerp, Antwerp, Belgium. Wouter.vangenechten22@gmail.com. + + + More Institute, Antwerp, Belgium. Wouter.vangenechten22@gmail.com. + + + Orthopedic Department, AZ Herentals, Herentals, Belgium. Wouter.vangenechten22@gmail.com. + + + + Van Haver + Annemieke + A + + More Institute, Antwerp, Belgium. + + + + Bartholomeeusen + Stijn + S + + Orthopedic Department, AZ Herentals, Herentals, Belgium. + + + + Claes + Toon + T + + Orthopedic Department, AZ Herentals, Herentals, Belgium. + + + + Van Beek + Nathalie + N + + Orthopedic Department, AZ Herentals, Herentals, Belgium. + + + + Michielsen + Jozef + J + + Orthopedic Department, University Hospital Antwerp, Antwerp, Belgium. + + + + Claes + Steven + S + + More Institute, Antwerp, Belgium. + + + + Verdonk + Peter + P + + Orthopedic Department, University Hospital Antwerp, Antwerp, Belgium. + + + More Institute, Antwerp, Belgium. + + + ORTHOCA, Antwerp, Belgium. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + J Exp Orthop + 101653750 + 2197-1153 + + + 3D planning + Accuracy + High tibial osteotomy + Joint preservation + Patient-specific instrumentation + +
+ + + + 2023 + 01 + 12 + + + 2023 + 03 + 06 + + + 2023 + 3 + 14 + 12 + 17 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917322 + 10.1186/s40634-023-00593-0 + 10.1186/s40634-023-00593-0 + + + + Van den Bempt M, Van Genechten W, Claes T, Claes S (2016) How accurately does high tibial osteotomy correct the mechanical axis of an arthritic varus knee? A systematic review Knee 23(6):925–935 + + 27776793 + + + + Kim JH, Kim HJ, Lee DH (2017) Survival of opening versus closing wedge high tibial osteotomy: A meta-Analysis. Sci Rep 7(1):1–7 + + + Heijens E, Kornherr P, Meister C (2016) The coronal hypomochlion: A tipping point of clinical relevance when planning valgus producing high tibial osteotomies. Bone Joint J 98(5):628–633 + + 10.1302/0301-620X.98B5.33394 + 27143733 + + + + van de Pol GJ, Verdonschot N, van Kampen A (2012) The value of the intra-operative clinical mechanical axis measurement in open-wedge valgus high tibial osteotomies. Knee 19(6):933–938 + + 10.1016/j.knee.2012.02.003 + 22421257 + + + + Takagawa S, Kobayashi N, Yukizawa Y, Oishi T, Tsuji M, Inaba Y (2020) Preoperative soft tissue laxity around knee was associated with less accurate alignment correction after hybrid closed-wedge high tibial osteotomy. Knee Surg Sports Traumatol Arthrosc 28(9):3022–3030 + + 10.1007/s00167-019-05762-2 + 31705147 + + + + Nguyen HC, Gielis WP, van Egmond N, Weinans H, Slump CH, Sakkers RJB, Custers RJH (2021) The need for a standardized whole leg radiograph guideline: The effects of knee flexion, leg rotation, and X-ray beam height. J Cartil Jt Preserv 1(3):100022 + + + Ducat A, Sariali E, Lebel B, Mertl P, Hernigou P, Flecher X, Zayni R, Bonnin M, Jalil R, Amzallag J, Rosset P, Servien E, Gaudot F, Judet T, Catonné Y (2012) Posterior tibial slope changes after opening- and closing-wedge high tibial osteotomy: A comparative prospective multicenter study. Orthop Traumatol Surg Res 98(1):68–74 + + 10.1016/j.otsr.2011.08.013 + 22244250 + + + + Nha KW, Kim HJ, Ahn HS, Lee DH (2016) Change in Posterior Tibial Slope after Open-Wedge and Closed-Wedge High Tibial Osteotomy. Am J Sports Med 44(11):3006–3013 + + 10.1177/0363546515626172 + 26872893 + + + + Kim GB, Il KK, Song SJ, Lee SH (2019) Increased Posterior Tibial Slope After Medial Open-Wedge High Tibial Osteotomy May Result in Degenerative Changes in Anterior Cruciate Ligament. J Arthroplasty 34(9):1922–1928 + + 10.1016/j.arth.2019.04.032 + 31103360 + + + + Hankemeier S, Mommsen P, Krettek C, Jagodzinski M, Brand J, Meyer C, Meller R (2010) Accuracy of high tibial osteotomy: comparison between open- and closed-wedge technique. Knee Surg Sports Traumatol Arthrosc 18(10):1328–1333 + + 10.1007/s00167-009-1020-9 + 20033672 + + + + Belsey J, DiffoKaze A, Jobson S, Faulkner J, Maas S, Khakha R, Wilson AJ, Pape D (2019) Graft materials provide greater static strength to medial opening wedge high tibial osteotomy than when no graft is included. J Exp Orthop 6(1):13 + + 10.1186/s40634-019-0184-6 + 30923931 + 6439028 + + + + Van Genechten W, Van den Bempt M, Van Tilborg W, Bartholomeeusen S, Van Den Bogaert G, Claes T, Claes S (2020) Structural allograft impaction enables fast rehabilitation in opening-wedge high tibial osteotomy: a consecutive case series with one year follow-up. Knee Surg Sports Traumatol Arthrosc 28(12):3747–3757 + + 10.1007/s00167-019-05765-z + 31713662 + + + + Victor J, Van Doninck D, Labey L, Innocenti B, Parizel PM, Bellemans J (2009) How precise can bony landmarks be determined on a CT scan of the knee? Knee 16(5):358–365 + + 10.1016/j.knee.2009.01.001 + 19195896 + + + + Lobenhoffer P, Agneskirchner JD (2003) Improvements in surgical technique of valgus high tibial osteotomy. Knee Surg Sports Traumatol Arthrosc 11(3):132–138 + + 10.1007/s00167-002-0334-7 + 12774149 + + + + Takeuchi R, Ishikawa H, Kumagai K, Yamaguchi Y, Chiba N, Akamatsu Y, Saito T (2012) Fractures around the lateral cortical hinge after a medial opening-wedge high tibial osteotomy: A new classification of lateral hinge fracture. Arthroscopy 28(1):85–94 + + 10.1016/j.arthro.2011.06.034 + 21982387 + + + + Van Genechten W, Van Tilborg W, Van Den Bempt M, Van Haver A, Verdonk P (2021) Feasibility and 3D Planning of a Novel Patient-Specific Instrumentation Technique in Medial Opening-Wedge High Tibial Osteotomy. J Knee Surg 34(14):1560–1569 + + 10.1055/s-0040-1710379 + 32443162 + + + + Victor J, Premanathan A (2013) Virtual 3D planning and patient specific surgical guides for osteotomies around the knee: a feasibility and proof-of-concept study. Bone Joint J 95 B(11 Suppl A):153–158 + + 10.1302/0301-620X.95B11.32950 + 24187376 + + + + Cerciello S, Ollivier M, Corona K, Kaocoglu B, Seil R (2022) CAS and PSI increase coronal alignment accuracy and reduce outliers when compared to traditional technique of medial open wedge high tibial osteotomy: a meta-analysis. Knee Surg Sports Traumatol Arthrosc 30(2):555–566 + + 10.1007/s00167-020-06253-5 + 32910222 + + + + Chaouche S, Jacquet C, Fabre-Aubrespy M, Sharma A, Argenson JN, Parratte S, Ollivier M (2019) Patient-specific cutting guides for open-wedge high tibial osteotomy: safety and accuracy analysis of a hundred patients continuous cohort. Int Orthop 43(12):2757–2765 + + 10.1007/s00264-019-04372-4 + 31273430 + + + + Fucentese SF, Meier P, Jud L, Köchli GL, Aichmair A, Vlachopoulos L, Fürnstahl P (2020) Accuracy of 3D-planned patient specific instrumentation in high tibial open wedge valgisation osteotomy. J Exp Orthop 7(1):1–7 + + 10.1186/s40634-020-00224-y + + + + Munier M, Donnez M, Ollivier M, Flecher X, Chabrand P, Argenson JN, Parratte S (2017) Can three-dimensional patient-specific cutting guides be used to achieve optimal correction for high tibial osteotomy? Pilot study Orthop Traumatol Surg Res 103(2):245–250 + + 10.1016/j.otsr.2016.11.020 + 28137553 + + + + Pérez-Mañanes R, Burró JA, Manaute JR, Rodriguez FC, Martín JV (2016) 3D Surgical Printing Cutting Guides for Open-Wedge High Tibial Osteotomy: Do It Yourself. J Knee Surg 29(8):690–695 + + 10.1055/s-0036-1572412 + 26907224 + + + + Saragaglia D, Roberts J (2005) Navigated osteotomies around the knee in 170 patients with osteoarthritis secondary to genu varum. Orthopedics 28(10 Suppl):s1269–s1274 + + 16235453 + + + + Schröter S, Ihle C, Elson DW, Döbele S, Stöckle U, Ateschrang A (2016) Surgical accuracy in high tibial osteotomy: coronal equivalence of computer navigation and gap measurement. Knee Surg Sports Traumatol Arthrosc 24(11):3410–3417 + + 10.1007/s00167-016-3983-7 + 26801783 + + + + Brinkman JM, Luites JWH, Wymenga AB, Van Heerwaarden RJ (2010) Early full weight bearing is safe in open-wedge high tibial osteotomy: RSA analysis of postoperative stability compared to delayed weight bearing. Acta Orthop 81(2):193–198 + + 10.3109/17453671003619003 + 20175658 + 2852156 + + + + Schröter S, Ateschrang A, Löwe W, Nakayama H, Stöckle U, Ihle C (2017) Early full weight-bearing versus 6-week partial weight-bearing after open wedge high tibial osteotomy leads to earlier improvement of the clinical results: a prospective, randomised evaluation. Knee Surg Sports Traumatol Arthrosc 25(1):325–332 + + 10.1007/s00167-015-3592-x + 25854499 + + + + Ekeland A, Nerhus TK, Dimmen S, Thornes E, Heir S (2017)  Good functional results following high tibial opening-wedge osteotomy of knees with medial osteoarthritis: A prospective study with a mean of 8.3 years of follow-up. Knee 24(2):380–389 + + 10.1016/j.knee.2016.12.005 + 28081898 + + + + Han SB, In Y, Oh KJ, Song KY, Yun ST, Jang KM (2019) Complications Associated With Medial Opening-Wedge High Tibial Osteotomy Using a Locking Plate: A Multicenter Study. J Arthroplasty 34(3):439–445 + + 10.1016/j.arth.2018.11.009 + 30503322 + + + + Seo S-S, Kim O-G, Seo J-H, Kim D-H, Kim Y-G, Lee I-S (2016) Complications and Short-Term Outcomes of Medial Opening Wedge High Tibial Osteotomy Using a Locking Plate for Medial Osteoarthritis of the Knee. Knee Surgery & Related Research 28(4):289–296 + + 10.5792/ksrr.16.028 + + + + +
+ + + 36917316 + + 2023 + 03 + 14 + +
+ + 1435-702X + + + 2023 + Mar + 14 + + + Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie + Graefes Arch Clin Exp Ophthalmol + + Effect of statins on the age of onset of age-related macular degeneration. + 10.1007/s00417-023-06017-0 + + This study evaluated the relationship between statin use and the age of onset of age-related macular degeneration (AMD). + Electronic Health Records from 52,840 patients evaluated at University of California Los Angeles (UCLA) Ophthalmology Clinics and 9,977 patients evaluated at University of California San Francisco (UCSF) Ophthalmology Clinics were screened. Survival analysis was performed using Cox proportional hazards regression models and visualized using Kaplan Meier survival curves, with the following covariates-sex, ethnicity, smoking history, fluoxetine use, obesity, diabetes mellitus, and hypertension. + 5,498 of 52,840 patients at UCLA were diagnosed with AMD. Statin use was associated with a later AMD onset (HR = 0.8823, p < 0.0001), while female sex (HR = 1.0852, p= 00,035), obesity (HR = 1.4555, p < 0.0001), and fluoxetine (HR = 1.3797, p= 0.0003) were associated with an earlier AMD onset. Non-hispanic black (HR = 0.5687, p < 0.0001) and hispanic ethnicities (HR = 0.8269, p= 0.0028) were associated with a later AMD onset. When stratifying for ethnicity, statins, fluoxetine, sex, and obesity were significant only within non-hispanic white subjects. Statin use was significant among patients with dry AMD (HR = 0.8410, p= 0.0001) but not wet AMD (0.9188, p= 0.0351). In the replication cohort, 526 of 9,977 patients at UCSF had AMD. Associations between statins (HR = 0.7643, p= 0.0033), non-hispanic black ethnicity (HR = 0.5043, p= 0.0035), and obesity (HR = 1.9602, p < 0.0001) on AMD onset were confirmed. + In both cohorts, statin use and non-hispanic black ethnicity are associated with a later AMD onset, while obesity with an earlier AMD onset. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Ganesh + Durga + D + + David Geffen School of Medicine, University of California - Los Angeles, Los Angeles, CA, USA. + + + Doheny Eye Institute, Pasadena, CA, USA. + + + + Chiang + Jeffrey N + JN + + Department of Computational Medicine, University of California - Los Angeles, Los Angeles, CA, USA. + + + + Corradetti + Giulia + G + + Doheny Eye Institute, Pasadena, CA, USA. + + + Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. + + + + Zaitlen + Noah + N + + Department of Computational Medicine, University of California - Los Angeles, Los Angeles, CA, USA. + + + Department of Neurology, University of California - Los Angeles, Los Angeles, CA, USA. + + + Department of Human Genetics, University of California - Los Angeles, Los Angeles, CA, USA. + + + + Halperin + Eran + E + + Department of Computational Medicine, University of California - Los Angeles, Los Angeles, CA, USA. + + + Department of Neurology, University of California - Los Angeles, Los Angeles, CA, USA. + + + Department of Human Genetics, University of California - Los Angeles, Los Angeles, CA, USA. + + + Department of Computer Science, University of California Los Angeles, Los Angeles, CA, USA. + + + Department of Anesthesiology, David Geffen School of Medicine at University of California - Los Angeles, Los Angeles, CA, USA. + + + Institute of Precision Health, University of California Los Angeles, Los Angeles, CA, USA. + + + + Sadda + Srinivas R + SR + + Doheny Eye Institute, Pasadena, CA, USA. ssadda@doheny.org. + + + Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. ssadda@doheny.org. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Graefes Arch Clin Exp Ophthalmol + 8205248 + 0721-832X + + IM + + Age-related Macular Degeneration + Non-neovascular Age-related Macular Degeneration + Regression + Statins + +
+ + + + 2022 + 07 + 25 + + + 2023 + 02 + 11 + + + 2023 + 02 + 06 + + + 2023 + 3 + 14 + 12 + 17 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917316 + 10.1007/s00417-023-06017-0 + 10.1007/s00417-023-06017-0 + + + + Wong WL, Su X, Li X, Cheung CM, Klein R, Cheng CY, Wong TY (2014) Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. Lancet Glob Health 2:106–116 + + 10.1016/S2214-109X(13)70145-1 + + + + Jonas JB, Cheung CM, Panda-Jonas S (2017) Updates on the epidemiology of age-related macular degeneration. Asia-Pac J Ophthalmol 6:493–497 + + + Mitchell P, Liew G, Gopinath B, Wong TY (2018) Age-related macular degeneration. Lancet 392:1147–1159 + + 30303083 + 10.1016/S0140-6736(18)31550-2 + + + + Thomas CJ, Mirza RG, Gill MK (2021) Age-Related Macular Degeneration. 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+ + + 36917329 + + 2023 + 03 + 14 + +
+ + 1573-7233 + + 42 + 1 + + 2023 + Mar + + + Cancer metastasis reviews + Cancer Metastasis Rev + + Biography-Dr. David Gewirtz. + + 1 + + 10.1007/s10555-023-10080-8 + eng + + Journal Article + +
+ + Netherlands + Cancer Metastasis Rev + 8605731 + 0167-7659 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 18 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + ppublish + + 36917329 + 10.1007/s10555-023-10080-8 + 10.1007/s10555-023-10080-8 + + +
+ + + 36917323 + + 2023 + 03 + 14 + +
+ + 1420-9071 + + 80 + 4 + + 2023 + Mar + 14 + + + Cellular and molecular life sciences : CMLS + Cell Mol Life Sci + + AAV-Net1 facilitates the trans-differentiation of supporting cells into hair cells in the murine cochlea. + + 86 + + 10.1007/s00018-023-04743-6 + + Mechanosensitive hair cells (HCs) in the cochlear sensory epithelium are critical for sound detection and transduction. Mammalian HCs in the cochlea undergo cytogenesis during embryonic development, and irreversible damage to hair cells postnatally is a major cause of deafness. During the development of the organ of Corti, HCs and supporting cells (SCs) originate from the same precursors. In the neonatal cochlea, damage to HCs activates adjacent SCs to act as HC precursors and to differentiate into new HCs. However, the plasticity of SCs to produce new HCs is gradually lost with cochlear development. Here, we delineate an essential role for the guanine nucleotide exchange factor Net1 in SC trans-differentiation into HCs. Net1 overexpression mediated by AAV-ie in SCs promoted cochlear organoid formation and HC differentiation under two and three-dimensional culture conditions. Also, AAV-Net1 enhanced SC proliferation in Lgr5-EGFPCreERT2 mice and HC generation as indicated by lineage tracing of HCs in the cochleae of Lgr5-EGFPCreERT2/Rosa26-tdTomatoloxp/loxp mice. We further found that the up-regulation of Wnt/β-catenin and Notch signaling in AAV-Net1-transduced cochleae might be responsible for the SC proliferation and HC differentiation. Also, Net1 overexpression in SCs enhanced SC proliferation and HC regeneration and survival after HC damage by neomycin. Taken together, our study suggests that Net1 might serve as a potential target for HC regeneration and that AAV-mediated gene regulation may be a promising approach in stem cell-based therapy in hearing restoration. + © 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG. + + + + Zhang + Liyan + L + + State Key Laboratory of Bioelectronics, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096, China. + + + + Fang + Yuan + Y + + State Key Laboratory of Bioelectronics, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096, China. + + + + Tan + Fangzhi + F + + State Key Laboratory of Bioelectronics, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096, China. + + + + Guo + Fangfang + F + + Department of Plastic and Reconstruction Surgery, Zhongda Hospital, Southeast University, 87 Dingjiaqiao Street, Nanjing, Jiangsu Province, China. + + + + Zhang + Ziyu + Z + + State Key Laboratory of Bioelectronics, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096, China. + + + + Li + Nianci + N + + State Key Laboratory of Bioelectronics, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096, China. + + + + Sun + Qiuhan + Q + + State Key Laboratory of Bioelectronics, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096, China. + + + + Qi + Jieyu + J + + State Key Laboratory of Bioelectronics, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096, China. jieyuqi@seu.edu.cn. + + + + Chai + Renjie + R + http://orcid.org/0000-0002-3885-543X + + State Key Laboratory of Bioelectronics, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096, China. renjiec@seu.edu.cn. + + + Department of Otolaryngology Head and Neck Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China. renjiec@seu.edu.cn. + + + Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China. renjiec@seu.edu.cn. + + + Institute for Stem Cell and Regeneration, Chinese Academy of Science, Beijing, China. renjiec@seu.edu.cn. + + + Beijing Key Laboratory of Neural Regeneration and Repair, Capital Medical University, Beijing, 100069, China. renjiec@seu.edu.cn. + + + + eng + + + 82000984 + National Natural Science Foundation of China + + + + 82030029 + National Natural Science Foundation of China + + + + 81970882 + National Natural Science Foundation of China + + + + BX20200082 + National Postdoctoral Program for Innovative Talents + + + + BE2019711 + Natural Science Foundation of Jiangsu Province + + + + JCYJ20190814093401920 + Shenzhen Fundamental Research Program + + + + JCYJ20210324125608022 + Shenzhen Fundamental Research Program + + + + 2020YFA0113600 + National Key Research and Development Program of China + + + + 2020YFA0112503 + National Key Research and Development Program of China + + + + 2021YFA1101300 + National Key Research and Development Program of China + + + + XDA16010303 + Strategic Priority Research Program of the Chinese Academy of Science + + + + 2020M681468 + China Postdoctoral Science Foundation + + + + SKLGE-2109 + Open Research Fund of State Key Laboratory of Genetic Engineering, Fudan University + + + + 2021YFS0371 + Science and Technology Department of Sichuan Province + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + Switzerland + Cell Mol Life Sci + 9705402 + 1420-682X + + IM + + AAV + Cochlea + Hair cell regeneration + Net1 + Organoid + +
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+ + + 36917328 + + 2023 + 03 + 14 + +
+ + 1573-6814 + + + 2023 + Mar + 14 + + + Cell and tissue banking + Cell Tissue Bank + + Matched comparison of decellularized homografts and bovine jugular vein conduits for pulmonary valve replacement in congenital heart disease. + 10.1007/s10561-023-10082-4 + + For decades, bovine jugular vein conduits (BJV) and classic cryopreserved homografts have been the two most widely used options for pulmonary valve replacement (PVR) in congenital heart disease. More recently, decellularized pulmonary homografts (DPH) have provided an alternative avenue for PVR. Matched comparison of patients who received DPH for PVR with patients who received bovine jugular vein conduits (BJV) considering patient age group, type of heart defect, and previous procedures. 319 DPH patients were matched to 319 BJV patients; the mean age of BJV patients was 15.3 (SD 9.5) years versus 19.1 (12.4) years in DPH patients (p = 0.001). The mean conduit diameter was 24.5 (3.5) mm for DPH and 20.3 (2.5) mm for BJV (p < 0.001). There was no difference in survival rates between the two groups after 10 years (97.0 vs. 98.1%, p = 0.45). The rate of freedom from endocarditis was significantly lower for BJV patients (87.1 vs. 96.5%, p = 0.006). Freedom from explantation was significantly lower for BJV at 10 years (81.7 vs. 95.5%, p = 0.001) as well as freedom from any significant degeneration at 10 years (39.6 vs. 65.4%, p < 0.001). 140 Patients, matched for age, heart defect type, prior procedures, and conduit sizes of 20-22 mm (± 2 mm), were compared separately; mean age BJV 8.7 (4.9) and DPH 9.5 (7.3) years (p = n.s.). DPH showed 20% higher freedom from explantation and degeneration in this subgroup (p = 0.232). Decellularized pulmonary homografts exhibit superior 10-year results to bovine jugular vein conduits in PVR. + © 2023. The Author(s). + + + + Bobylev + Dmitry + D + + Department for Cardiothoracic, Transplant, and Vascular Surgery, Hannover Medical School, Hannover, Germany. + + + + Horke + Alexander + A + + Department for Cardiothoracic, Transplant, and Vascular Surgery, Hannover Medical School, Hannover, Germany. + + + + Avsar + Murat + M + + Department for Cardiothoracic, Transplant, and Vascular Surgery, Hannover Medical School, Hannover, Germany. + + + + Cvitkovic + Tomislav + T + + Department for Cardiothoracic, Transplant, and Vascular Surgery, Hannover Medical School, Hannover, Germany. + + + + Boethig + Dietmar + D + + Department for Cardiothoracic, Transplant, and Vascular Surgery, Hannover Medical School, Hannover, Germany. + + + + Hazekamp + Mark + M + + Department of Congenital Cardiac Surgery, Leiden University Medical Center, Leiden, The Netherlands. + + + + Meyns + Bart + B + + Department of Cardiac Surgery, Katholieke Universiteit Leuven, Leuven, Belgium. + + + + Rega + Filip + F + + Department of Cardiac Surgery, Katholieke Universiteit Leuven, Leuven, Belgium. + + + + Dave + Hitendu + H + + Division of Congenital Cardiovascular Surgery, University Children's Hospital, Zurich, Switzerland. + + + + Schmiady + Martin + M + + Division of Congenital Cardiovascular Surgery, University Children's Hospital, Zurich, Switzerland. + + + Cardiac Surgery Center, State Medical and Pharmaceutical University, Chisinau, Moldova. + + + + Ciubotaru + Anatol + A + + Cardiac Surgery Center, State Medical and Pharmaceutical University, Chisinau, Moldova. + + + + Cheptanaru + Eduard + E + + Cardiac Surgery Center, State Medical and Pharmaceutical University, Chisinau, Moldova. + + + + Vida + Vladimiro + V + + Pediatric and Congenital Cardiac Surgery Unit, Azienda Ospedaliera di Padova, University of Padua Medical School, Padua, Italy. + + + + Padalino + Massimo + M + + Pediatric and Congenital Cardiac Surgery Unit, Azienda Ospedaliera di Padova, University of Padua Medical School, Padua, Italy. + + + + Tsang + Victor + V + + Department of Cardiothoracic Surgery, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, UK. + + + + Jashari + Ramadan + R + + European Homograft Bank, Clinique Saint-Jean, Brussels, Belgium. + + + + Laufer + Günther + G + + Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria. + + + + Andreas + Martin + M + + Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria. + + + + Andreeva + Alexandra + A + + Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria. + + + + Tudorache + Igor + I + + Department for Cardiothoracic, Transplant, and Vascular Surgery, Hannover Medical School, Hannover, Germany. + + + + Cebotari + Serghei + S + + Department for Cardiothoracic, Transplant, and Vascular Surgery, Hannover Medical School, Hannover, Germany. + + + + Haverich + Axel + A + + Department for Cardiothoracic, Transplant, and Vascular Surgery, Hannover Medical School, Hannover, Germany. + + + + Sarikouch + Samir + S + http://orcid.org/0000-0001-7277-7597 + + Department for Cardiothoracic, Transplant, and Vascular Surgery, Hannover Medical School, Hannover, Germany. sarikouch.samir@mh-hannover.de. + + + + eng + + + No. 278453 + European Commission + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + Netherlands + Cell Tissue Bank + 100965121 + 1389-9333 + + IM + + Allografts + Decellularization + Heart valve disease + Tissue engineering + +
+ + + + 2022 + 10 + 13 + + + 2023 + 02 + 23 + + + 2023 + 3 + 14 + 12 + 17 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917328 + 10.1007/s10561-023-10082-4 + 10.1007/s10561-023-10082-4 + + + + Abdelghani M, Nassif M, Blom NA, Van Mourik MS, Straver B, Koolbergen DR et al (2018) Infective endocarditis after melody valve implantation in the pulmonary position: a systematic review. J Am Heart Assoc 7:e008163 + + 10.1161/JAHA.117.008163 + 29934419 + 6064882 + + + + Bobylev D, Horke A, Boethig D, Hazekamp M, Meyns B, Rega F et al (2022) 5-Year results from the prospective European multi-centre study on decellularized homografts for pulmonary valve replacement ESPOIR Trial and ESPOIR Registry data. Eur J Cardiothorac Surg 62(5):ezac219 + + 10.1093/ejcts/ezac219 + 35425983 + 9615428 + + + + Boethig D, Westhoff-Bleck M, Hecker H, Ono M, Goerler A, Sarikouch S et al (2009) Bovine jugular veins in the pulmonary position in adults – 5 years’ experience with 64 implantations. Thorac Cardiovasc Surg 57:196–201 + + 10.1055/s-0029-1185394 + 19670110 + + + + Boethig D, Schreiber C, Hazekamp M, Blanz U, Pretre R, Asfour B et al (2012) Risk factors for distal Contegra stenosis: results of a prospective European multicentre study. Thorac Cardiovasc Surg 60:195–204 + + 10.1055/s-0031-1298062 + 22228091 + + + + Bokma JP, Winter MM, Oosterhof T, Vliegen HW, van Dijk AP, Hazekamp MG et al (2015) Individualised prediction of pulmonary homograft durability in tetralogy of Fallot. Heart 101:1717–1723 + + 10.1136/heartjnl-2015-307754 + 26175476 + + + + Breymann T, Blanz U, Wojtalik MA, Daenen W, Hetzer R, Sarris G et al (2009) European Contegra multicentre study: 7-year results after 165 valved bovine jugular vein graft implantations. Thorac Cardiovasc Surg 57:257–269 + + 10.1055/s-0029-1185513 + 19629887 + + + + Contegra pulmonary valved conduit FDA executive summary. 2020 FDA Pediatric advisory committee meeting. Last accessed 05.07.2022 + + + Ebken JMN, Smart I, Ramm R, Goecke T, Jashari R, Böthig D, Horke A, Cebotari S, Tudorache I, Avsar M, Bobylev D, Haverich A, Sarikouch S, Hilfiker A (2021) Residual immune response towards decellularized homografts may be highly individual. Eur J Cardiothorac Surg 59(4):773–782 + + 10.1093/ejcts/ezaa393 + 33544830 + + + + Fiore AC, Ruzmetov M, Huynh D, Hanley S, Rodefeld MD, Turrentine MW et al (2010) Comparison of bovine jugular vein with pulmonary homograft conduits in children less than 2 years of age. Eur J Cardio-Thorac 38:318–325 + + 10.1016/j.ejcts.2010.01.063 + + + + Horke A, Bobylev D, Avsar M, Meyns B, Rega F, Hazekamp M et al (2020) Paediatric aortic valve replacement using decellularized allografts. Eur J Cardiothorac Surg 58(4):817–824 + + 10.1093/ejcts/ezaa119 + 32443152 + 7890932 + + + + Jashari R (2021) Transplantation of cryopreserved human heart valves in Europe: 30 years of banking in Brussels and future perspectives. Cell Tissue Bank 22(4):519–537 + + 10.1007/s10561-021-09902-2 + 33532987 + 7853167 + + + + Khanna AD, Hill KD, Pasquali SK, Wallace AS, Masoudi FA, Jacobs ML et al (2015) Benchmark outcomes for pulmonary valve replacement using the society of thoracic surgeons databases. Ann Thorac Surg 100:138–145 + + 10.1016/j.athoracsur.2015.03.025 + 26007205 + + + + Marathe SP, Hussein N, Wallace FRO, Bell D, Yong M, Betts KS et al (2021) Comparison of homografts and bovine jugular vein conduits in the pulmonary position in patients <20 years of age. J Thorac Cardiovasc Surg 164:752–762 + + 10.1016/j.jtcvs.2021.11.087 + 35058063 + + + + Meijer FMM, Kies P, Jongbloed MRM, Hazekamp MG, Koolbergen DR, Blom NA et al (2019) Excellent durability of homografts in pulmonary position analysed in a predefined adult group with tetralogy of Fallot. Interact Cardiovasc Thorac Surg 28:279–283 + + 10.1093/icvts/ivy242 + 30102354 + + + + Patel PM, Herrmann JL, Rodefeld MD, Turrentine MW, Brown JW (2020) Bovine jugular vein conduit versus pulmonary homograft in the ross operation. Cardiol Young 30:323–327 + + 10.1017/S1047951119003007 + 31847922 + + + + Poinot N, Fils JF, Demanet H, Dessy H, Biarent D, Wauthy P (2018) Pulmonary valve replacement after right ventricular outflow tract reconstruction with homograft vs Contegra(R): a case control comparison of mortality and morbidity. J Cardiothorac Surg 13:8 + + 10.1186/s13019-018-0698-5 + 29343297 + 5773189 + + + + Ramm R, Goecke T, Köhler P, Tudorache I, Cebotari S, Ciubotaru A, Sarikouch S, Höffler K, Bothe F, Petersen B, Haverich A, Niemann H, Hilfiker A (2021) Immunological and functional features of decellularized xenogenic heart valves after transplantation into GGTA1-KO pigs. Regen Biomat 8:036 + + 10.1093/rb/rbab036 + + + + Sandica E, Boethig D, Blanz U, Goerg R, Haas NA, Laser KT et al (2016) bovine jugular veins versus homografts in the pulmonary position: an analysis across two centers and 711 patients-conventional comparisons and time status graphs as a new approach. Thorac Cardiovasc Surg 64:25–35 + + 26322831 + + + + Simon P, Kasimir MT, Seebacher G, Weigel G, Ullrich R, Salzer-Muhar U et al (2003) Early failure of the tissue engineered porcine heart valve SYNERGRAFT in pediatric patients. Eur J Cardiothorac Surg 23:1002–1006 + + 10.1016/S1010-7940(03)00094-0 + 12829079 + + + + Stammnitz C, Huscher D, Bauer UMM, Urban A, Nordmeyer J, Schubert S et al (2022) Nationwide registry-based analysis of infective endocarditis risk after pulmonary valve replacement. J Am Heart Assoc 11:e022231 + + 10.1161/JAHA.121.022231 + 35179045 + 9075093 + + + + Waqanivavalagi S, Bhat S, Ground MB, Milsom PF, Cornish J (2020) Clinical performance of decellularized heart valves versus standard tissue conduits: a systematic review and meta-analysis. J Cardiothorac Surg 15:260 + + 10.1186/s13019-020-01292-y + 32948234 + 7501674 + + + + Williams DF, Bezuidenhout D, de Villiers J, Human P, Zilla P (2021) Long-term stability and biocompatibility of pericardial bioprosthetic heart valves. Front Cardiovasc Med 8:728577 + + 10.3389/fcvm.2021.728577 + 34589529 + 8473620 + + + + Yong MS, Yim D, d’Udekem Y, Brizard CP, Robertson T, Galati JC et al (2015) Medium-term outcomes of bovine jugular vein graft and homograft conduits in children. ANZ J Surg 85:381–385 + + 10.1111/ans.13018 + 25708132 + + + + +
+ + + 36917324 + + 2023 + 03 + 14 + +
+ + 1573-2630 + + + 2023 + Mar + 14 + + + International ophthalmology + Int Ophthalmol + + Systematic review of sample size calculations and reporting in randomized controlled trials in ophthalmology over a 20-year period. + 10.1007/s10792-023-02687-1 + + Randomized Controlled Trials (RCTs) are considered the gold standard for the practice of evidence-based medicine. The purpose of this study is to systematically assess the reporting of sample size calculations in ophthalmology RCTs in 5 leading journals over a 20-year period. Reviewing sample size calculations in ophthalmology RCTs will shed light on the methodological quality of RCTs and, by extension, on the validity of published results. + The MEDLINE database was searched to identify full reports of RCTs in the journals Ophthalmology, JAMA Ophthalmology, American Journal of Ophthalmology, Investigative Ophthalmology and Visual Science, and British Journal of Ophthalmology between January and December of the years 2000, 2010 and 2020. Screening identified 559 articles out of which 289 met the inclusion criteria for this systematic review. Data regarding sample size calculation reporting and trial characteristics was extracted for each trial by independent investigators. + In 2020, 77.9% of the RCTs reported sample size calculations as compared with 37% in 2000 (p < 0.001) and 60.7% in 2010 (p = 0.012). Studies reporting all necessary parameters for sample size recalculation increased significantly from 17.2% in 2000 to 39.3% in 2010 and 43.0% in 2020 (p < 0.001). Reporting of funding was greater in 2020 (98.8%) compared with 2010 (89.3%) and 2000 (53.1%). Registration in a clinical trials database occurred more frequently in 2020 (94.2%) compared to 2000 (1.2%; p < 0.001) and 2010 (68%; p < 0.001). In 2020, 38.4% of studies reported different sample sizes in the online registry from the published article. Overall, the most studied area in 2000 was glaucoma (29.6% of RCTs), whereas in 2010 and 2020, it was retina (40.2 and 37.2% of the RCTs, respectively). The number of patients enrolled in a study and the number of eyes studied was significantly greater in 2020 compared to 2000 and 2010 (p < 0.001). + Sample size calculation reporting in ophthalmology RCTs has improved significantly between the years 2000 and 2020 and is comparable to other fields in medicine. However, reporting of certain parameters remains inconsistent with current publication guidelines. + © 2023. The Author(s), under exclusive licence to Springer Nature B.V. + + + + Kounatidou + Nefeli Eleni + NE + http://orcid.org/0000-0003-2459-7123 + + Medical School, National and Kapodistrian University of Athens, Athens, Greece. + + + + Tzavara + Chara + C + http://orcid.org/0000-0003-3242-9066 + + Department of Biostatistics, National and Kapodistrian University of Athens Medical School, Athens, Greece. + + + + Palioura + Sotiria + S + http://orcid.org/0000-0002-1601-9799 + + Department of Ophthalmology, University of Cyprus Medical School, Aglantzia, Cyprus. sotiria.palioura@gmail.com. + + + + eng + + Journal Article + Review + + + 2023 + 03 + 14 + +
+ + Netherlands + Int Ophthalmol + 7904294 + 0165-5701 + + IM + + RCTs + Randomized clinical trials + Sample size + Sample size calculation + Sample size reporting + +
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+ + + 36917318 + + 2023 + 03 + 14 + +
+ + 1563-258X + + + 2023 + Mar + 14 + + + Wiener medizinische Wochenschrift (1946) + Wien Med Wochenschr + + Olfactory identification, cognition, depressive symptoms, and 5-year mortality in patients with subjective cognitive decline, mild cognitive impairment, and Alzheimer's disease. + 10.1007/s10354-023-01008-6 + + An association between odor and cognitive impairment has been shown in many studies. The objective of the present hospital-based, single-center retrospective study was to assess the impact of odor impairment on the mortality of patients with Alzheimer's disease (AD), subjective cognitive decline (SCD), and mild cognitive impairment (MCI). + Odor function was measured by Sniffin Sticks (Burghart Messtechnik, Holm, Germany) and the assessment of self-reported olfactory functioning and olfaction-related quality of life (ASOF) test. Cognitive performance was assessed by an extensive neuropsychological test battery, symptoms of depression were diagnosed with the Geriatric Depressive Scale (GDS). The influence of demographic factors such as gender, age, and education were examined. + Although the univariate analyses and pairwise post hoc comparison showed significant differences for some of the olfactory performance tests/subtests, the multivariate models showed no association between olfactory test performance and mortality among patients with cognitive impairment. "Attention," a domain of the Neuropsychological Test Battery Vienna (NTBV), as well as depressive symptoms, gender, and age, showed a significant influence on the mortality of the patient group. + Lower olfactory performance showed no impact on mortality. However, decreased cognitive function of "Attention" can be considered as an influential predictor for mortality. + © 2023. The Author(s). + + + + Pusswald + Gisela + G + + Department of Neurology, Medical University of Vienna, Vienna, Austria. + + + + Dapić + Blaz + B + + Department of Neurology, Medical University of Vienna, Vienna, Austria. + + + + Bum + Carina + C + + Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria. + + + + Schernhammer + Eva + E + + Department of Epidemiology, Center for Public Health, Medical University of Vienna, Vienna, Austria. + + + + Stögmann + Elisabeth + E + + Department of Neurology, Medical University of Vienna, Vienna, Austria. + + + + Lehrner + Johann + J + http://orcid.org/0000-0001-8270-9272 + + Department of Neurology, Medical University of Vienna, Vienna, Austria. Johann.Lehrner@meduniwien.ac.at. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Austria + Wien Med Wochenschr + 8708475 + 0043-5341 + + IM + + Aging + Cognitive decline + Dementia + Mortality + Olfactory impairment + +
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+ + + 36917330 + + 2023 + 03 + 14 + +
+ + 1433-7339 + + 31 + 4 + + 2023 + Mar + 14 + + + Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer + Support Care Cancer + + Comorbidities and their management in women with breast cancer-an Australian survey of breast cancer survivors. + + 212 + + 10.1007/s00520-023-07678-7 + + Breast cancer survivors experience significant burden from comorbid chronic conditions, but little is known about how well these conditions are managed. We conducted a national survey of Australian breast cancer survivors to examine the burden of chronic conditions, their impact and care alignment with the principles of chronic condition management. + A study-specific survey incorporated questions about chronic conditions using the Charlson Comorbidity Index (CCI), functional status using the Vulnerable Elders Survey (VES) and perceived quality of care for cancer and non-cancer conditions using the Patient Assessment of Care for Chronic Conditions Survey (PACIC). Members of Breast Cancer Network Australia (BCNA) were invited via email to complete the survey either online or through direct mail. + The survey was sent to 2198 BCNA members and 177 responses were received (8.1%). Respondents were women aged 32-88 years (median 60.1 years). The majority were married (116; 67.7%) and had private insurance (137; 80.0%) and reported good to excellent health (119; 73.5%). Other health conditions were reported by 157 (88.7%), the most common being chronic pain (27.1%) and fatigue (22.0%). When asked about management of comorbidities or cancer, less than 20% were routinely asked about management goals, helped to set goals or asked about health habits. + In this population of survivors with good health status and high rates of private insurance, comorbidities were common and their management, as well as management of breast cancer, was poorly aligned with chronic condition management principles. + © 2023. The Author(s). + + + + Koczwara + Bogda + B + http://orcid.org/0000-0002-1201-1642 + + College of Medicine and Public Health, Flinders University, Adelaide, Australia. bogda.koczwara@flinders.edu.au. + + + + Meng + Rosie + R + http://orcid.org/0000-0001-8935-358X + + College of Medicine and Public Health, Flinders University, Adelaide, Australia. + + + + Battersby + Malcolm + M + http://orcid.org/0000-0001-7306-5591 + + College of Medicine and Public Health, Flinders University, Adelaide, Australia. + + + + Mangoni + Arduino A + AA + http://orcid.org/0000-0001-8699-1412 + + College of Medicine and Public Health, Flinders University, Adelaide, Australia. + + + + Spence + Danielle + D + + Cancer Council Victoria, Melbourne, Australia. + + + + Lawn + Sharon + S + http://orcid.org/0000-0002-5464-8887 + + College of Medicine and Public Health, Flinders University, Adelaide, Australia. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Support Care Cancer + 9302957 + 0941-4355 + + IM + + Breast cancer + Chronic disease + Comorbidity + +
+ + + + 2022 + 07 + 01 + + + 2023 + 03 + 07 + + + 2023 + 3 + 14 + 12 + 18 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917330 + 10.1007/s00520-023-07678-7 + 10.1007/s00520-023-07678-7 + + + + Ogle KS, Swanson GM, Woods N, Azzouz F (2000) Cancer and comorbidity. Cancer 88:653–663. https://doi.org/10.1002/(SICI)1097-0142(20000201)88:33.0.CO;2-1 + + 10.1002/(SICI)1097-0142(20000201)88:33.0.CO;2-1 + 10649261 + + + + Ng HS, Vitry A, Koczwara B, Roder D, McBride ML (2019) Patterns of comorbidities in women with breast cancer: a Canadian population-based study. Cancer Causes Control 30:931–941. https://doi.org/10.1007/s10552-019-01203-0 + + 10.1007/s10552-019-01203-0 + 31280456 + + + + Ng HS, Koczwara B, Roder DM, Niyonsenga T, Vitry AI (2018) Comorbidities in Australian women with hormone-dependent breast cancer: a population-based analysis. 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Aust Health Rev 44(3):470–479. https://doi.org/10.1071/AH18184 + + 10.1071/AH18184 + 31693479 + + + + Nekhlyudov L, Mollica MA, Jacobsen PB, Mayer DK, Shulman LN, Geiger AM (2019) Developing a quality of cancer survivorship care framework: implications for clinical care, research, and policy. J Natl Cancer Inst 111(11):1120–1130. https://doi.org/10.1093/jnci/djz089 + + 10.1093/jnci/djz089 + 31095326 + 6855988 + + + + Sarfati D, Koczwara B, Jackson C (2016) The impact of comorbidity on cancer and its treatment. CA Cancer J Clin 66(4):337–350. https://doi.org/10.3322/caac.21342 + + 10.3322/caac.21342 + 26891458 + + + + Clark RA, Marin TS, Berry NM, Atherton JJ, Foote JW, Koczwara B (2017) Cardiotoxicity and cardiovascular disease risk assessment for patients receiving breast cancer treatment. Cardiooncology 17(3):6. https://doi.org/10.1186/s40959-017-0025-7 + + 10.1186/s40959-017-0025-7 + + + + Webster S, Lawn S, Chan R, Koczwara B (2020) The role of comorbidity assessment in guiding treatment decision-making for women with early breast cancer: a systematic literature review. Support Care Cancer 28(3):1041–1050. https://doi.org/10.1007/s00520-019-05218-w + + 10.1007/s00520-019-05218-w + 31828493 + + + + Kemp EB, Geerse OP, Knowles R, Woodman R, Mohammadi L, Nekhlyudov L, Koczwara B (2022) Mapping systematic reviews of breast cancer survivorship interventions: a network analysis. J Clin Oncol JCO2102015. https://doi.org/10.1200/JCO.21.02015 + + + Cavers D, Habets L, Cunningham-Burley S, Watson E, Banks E, Campbell C (2019) Living with and beyond cancer with comorbid illness: a qualitative systematic review and evidence synthesis. 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BMC Cancer 20(1):2. https://doi.org/10.1186/s12885-019-6472-9 + + 10.1186/s12885-019-6472-9 + 31987032 + 6986047 + + + + Lawn S, Battersby M (2016) Chronic condition management models for cancer care and survivorship. In: Koczwara, B. (eds) Cancer and chronic conditions. Springer, Singapore. https://doi.org/10.1007/978-981-10-1844-2_8 + + + +
+ + + 36917335 + + 2023 + 03 + 14 + +
+ + 1534-4681 + + + 2023 + Mar + 14 + + + Annals of surgical oncology + Ann Surg Oncol + + The Association Between Surgical Axillary Staging, Adjuvant Treatment Use and Survival in Older Women with Early Stage Breast Cancer: A Population-Based Study. + 10.1245/s10434-023-13274-0 + + Choosing Wisely guidelines recommend against surgical axillary staging (AS) in women ≥70 years with ER+/HER2- early stage breast cancer (BC). This study examined the impact of AS omission on survival in older patients with BC. + This was a population-based cohort study using health administrative data in Ontario, Canada. We identified women aged 65-95 years who underwent surgery for Stage I/II BC between 2010 and 2016. Patients were weighted by propensity scores for receipt of AS that included patient and disease characteristics using overlap weights. Association with overall survival (OS) was calculated using weighted Cox models, and breast cancer-specific survival (BCSS) was calculated using weighted Fine and Gray models, adjusting for biomarkers and adjuvant treatments. Adjuvant treatment receipt was modelled with weighted log-binomial models. + Among 17,370 older women, the 1771 (10.2%) who did not undergo AS were older, more comorbid, and less likely to undergo mastectomy. Women who did not undergo AS were less likely to receive adjuvant chemotherapy (RR 0.68, 95% CI 0.57-0.82), endocrine therapy (RR 0.85, 95% CI 0.81-0.89) or radiotherapy (RR 0.69, 95% CI 0.65-0.74). After weighting and adjustment, there was no significant difference in BCSS (sdHR 0.98, 95% CI 0.77-1.25), but women who did not undergo AS had worse OS (HR 1.14, 95% CI 1.04-1.25). The results among 6215 ER+/HER2- women ≥70 years undergoing SLNB vs no AS were similar. + The omission of AS in older women with early stage BC was not associated with adverse BCSS, although OS was worse. + © 2023. Society of Surgical Oncology. + + + + Castelo + Matthew + M + + Department of Surgery, University of Toronto, Toronto, ON, Canada. + + + Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. + + + + Sutradhar + Rinku + R + + Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. + + + ICES, Toronto, ON, Canada. + + + + Faught + Neil + N + + ICES, Toronto, ON, Canada. + + + + Mata + Danilo Giffoni M M + DGMM + + Department of Medical Oncology, Sunnybrook Odette Cancer Centre, Toronto, ON, Canada. + + + Department of Medicine, London Health Sciences Center, London, ON, Canada. + + + + Hahn + Ezra + E + + Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada. + + + Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Canada. + + + + Nguyen + Lena + L + + ICES, Toronto, ON, Canada. + + + + Paszat + Lawrence + L + + Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. + + + ICES, Toronto, ON, Canada. + + + Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada. + + + Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada. + + + + Rodin + Danielle + D + + Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada. + + + Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Canada. + + + + Trebinjac + Sabina + S + + Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada. + + + + Fong + Cindy + C + + ICES, Toronto, ON, Canada. + + + + Rakovitch + Eileen + E + + ICES, Toronto, ON, Canada. eileen.rakovitch@sunnybrook.ca. + + + Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada. eileen.rakovitch@sunnybrook.ca. + + + Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada. eileen.rakovitch@sunnybrook.ca. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Ann Surg Oncol + 9420840 + 1068-9265 + + IM +
+ + + + 2022 + 10 + 13 + + + 2023 + 01 + 12 + + + 2023 + 3 + 14 + 12 + 18 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917335 + 10.1245/s10434-023-13274-0 + 10.1245/s10434-023-13274-0 + + + + Liang S, Hallet J, Simpson JS, Tricco AC, Scheer AS. Omission of axillary staging in elderly patients with early stage breast cancer impacts regional control but not survival: a systematic review and meta-analysis. J Geriatr Oncol. 2017;8(2):140–7. https://doi.org/10.1016/j.jgo.2016.12.003 . + + 10.1016/j.jgo.2016.12.003 + 27986500 + + + + Martelli G, Boracchi P, Ardoino I, et al. Axillary dissection versus no axillary dissection in older patients with T1N0 breast cancer: 15-year results of a randomized controlled trial. Ann Surg. 2012;256(6):920–4. + + 10.1097/SLA.0b013e31827660a8 + 23154393 + + + + Rudenstam CM, Zahrieh D, Forbes JF, et al. Randomized trial comparing axillary clearance versus no axillary clearance in older patients with breast cancer: first results of International Breast cancer study group trial 10–93. J Clin Oncol Off J Am Soc Clin Oncol. 2006;24(3):337–44. + + 10.1200/JCO.2005.01.5784 + + + + Gradishar WJ, Anderson BO, Abraham J. NCCN Guidelines. Breast Cancer. Published online 2019:215. https://www.nccn.org/professionals/physician_gls/pdf/breast.pdf + + + Society of Surgical Oncology. Choosing Wisely. Accessed October 25, 2020. https://www.choosingwisely.org/societies/society-of-surgical-oncology/ + + + Smith ME, Vitous CA, Hughes TM, Shubeck SP, Jagsi R, Dossett LA. Barriers and facilitators to de-implementation of the choosing wisely® guidelines for low-value breast cancer surgery. Ann Surg Oncol. 2020;27(8):2653–63. https://doi.org/10.1245/s10434-020-08285-0 . + + 10.1245/s10434-020-08285-0 + 32124126 + 7338259 + + + + Minami CA, Bryan AF, Freedman RA, et al. Assessment of oncologists’ perspectives on omission of sentinel lymph node biopsy in women 70 years and older with early-stage hormone receptor-positive breast cancer. JAMA Netw Open. 2022;5(8):e2228524. https://doi.org/10.1001/jamanetworkopen.2022.28524 . + + 10.1001/jamanetworkopen.2022.28524 + 36001314 + 9403774 + + + + Castelo M, Hansen BE, Paszat L, Baxter NN, Scheer AS. Omission of axillary staging and survival in elderly women with early stage breast cancer: a population-based cohort study. Ann Surg Open. 2022;3(2):e159. https://doi.org/10.1097/AS9.0000000000000159 . + + 10.1097/AS9.0000000000000159 + + + + Wang T, Baskin AS, Dossett LA. Deimplementation of the choosing wisely recommendations for low-value breast cancer surgery: a systematic review. JAMA Surg. 2020. https://doi.org/10.1001/jamasurg.2020.0322 . + + 10.1001/jamasurg.2020.0322 + 32902630 + 7489412 + + + + Chagpar AB, Hatzis C, Pusztai L, et al. Association of LN evaluation with survival in women aged 70 years or older with clinically node-negative hormone receptor positive breast cancer. Ann Surg Oncol. 2017;24(10):3073–81. + + 10.1245/s10434-017-5936-x + 28766195 + + + + Aziz D, Gardner S, Pritchard K, Paszat L, Holloway CMB. Selective application of axillary node dissection in elderly women with early breast cancer. Ann Surg Oncol. 2007;14(2):652–9. https://doi.org/10.1245/s10434-006-9092-y . + + 10.1245/s10434-006-9092-y + 17151795 + + + + ICES. Accessed May 6, 2019. https://www.ices.on.ca/ + + + von Elm E, Altman DG, Egger M, et al. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet Lond Engl. 2007;370(9596):1453–7. https://doi.org/10.1016/S0140-6736(07)61602-X . + + 10.1016/S0140-6736(07)61602-X + + + + Government of Canada SC. Dictionary, census of population, 2016–Economic family after-tax income decile group. Published May 3, 2017. Accessed December 31, 2021. https://www12.statcan.gc.ca/census-recensement/2016/ref/dict/pop166-eng.cfm + + + Mehta N, Kalra A, Nowacki AS, et al. Association of use of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers with testing positive for coronavirus disease 2019 (COVID-19). JAMA Cardiol. 2020. https://doi.org/10.1001/jamacardio.2020.1855 . + + 10.1001/jamacardio.2020.1855 + 33185652 + 7666433 + + + + Thomas LE, Li F, Pencina MJ. Overlap weighting: a propensity score method that mimics attributes of a randomized clinical trial. JAMA. 2020;323(23):2417–8. https://doi.org/10.1001/jama.2020.7819 . + + 10.1001/jama.2020.7819 + 32369102 + + + + Li F, Morgan KL, Zaslavsky AM. Balancing covariates via propensity score weighting. J Am Stat Assoc. 2018;113(521):390–400. https://doi.org/10.1080/01621459.2016.1260466 . + + 10.1080/01621459.2016.1260466 + + + + Bolch CA, Chu H, Jarosek S, Cole SR, Elliott S, Virnig B. Inverse probability of treatment-weighted competing risks analysis: an application on long-term risk of urinary adverse events after prostate cancer treatments. BMC Med Res Methodol. 2017. https://doi.org/10.1186/s12874-017-0367-8 . + + 10.1186/s12874-017-0367-8 + 28693428 + 5504854 + + + + Wang T, Bredbeck BC, Sinco B, et al. Variations in persistent use of low-value breast cancer surgery. JAMA Surg. 2021. https://doi.org/10.1001/jamasurg.2020.6942 . + + 10.1001/jamasurg.2020.6942 + 34232277 + 8567187 + + + + Chagpar AB, Horowitz N, Sanft T, et al. Does lymph node status influence adjuvant therapy decision-making in women 70 years of age or older with clinically node negative hormone receptor positive breast cancer? Am J Surg. 2017;214(6):1082–8. https://doi.org/10.1016/j.amjsurg.2017.07.036 . + + 10.1016/j.amjsurg.2017.07.036 + 28939252 + + + + Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40(5):373–83. https://doi.org/10.1016/0021-9681(87)90171-8 . + + 10.1016/0021-9681(87)90171-8 + 3558716 + + + + Austin SR, Wong YN, Uzzo RG, Beck JR, Egleston BL. Why summary comorbidity measures such as the Charlson Comorbidity Index and Elixhauser score work. Med Care. 2015;53(9):e65–72. https://doi.org/10.1097/MLR.0b013e318297429c . + + 10.1097/MLR.0b013e318297429c + 23703645 + 3818341 + + + + +
+ + + 36917333 + + 2023 + 03 + 14 + +
+ + 1534-4681 + + + 2023 + Mar + 14 + + + Annals of surgical oncology + Ann Surg Oncol + + Survival for Patients with Radiographically Occult Metastatic Pancreatic Cancer in the Era of Modern Multiagent Chemotherapy. + 10.1245/s10434-023-13318-5 + + + Eckhoff + Austin M + AM + + Department of Surgery, Duke University, Durham, NC, USA. + + + + Kanu + Elishama + E + + Department of Surgery, Duke University, Durham, NC, USA. + + + + Bao + Matthew + M + + Department of Surgery, Duke University, Durham, NC, USA. + + + + Blazer + Dan G + DG + 3rd + + Department of Surgery, Duke University, Durham, NC, USA. + + + + Zani + Sabino + S + + Department of Surgery, Duke University, Durham, NC, USA. + + + + Lidsky + Michael E + ME + + Department of Surgery, Duke University, Durham, NC, USA. + + + + Allen + Peter J + PJ + + Department of Surgery, Duke University, Durham, NC, USA. + + + + Nussbaum + Daniel P + DP + + Department of Surgery, Duke University, Durham, NC, USA. daniel.nussbaum@duke.edu. + + + + eng + + + P30 CA014236 + CA + NCI NIH HHS + United States + + + T32-CA093245 + CA + NCI NIH HHS + United States + + + + Letter + + + 2023 + 03 + 14 + +
+ + United States + Ann Surg Oncol + 9420840 + 1068-9265 + + IM +
+ + + + 2023 + 01 + 05 + + + 2023 + 02 + 20 + + + 2023 + 3 + 14 + 12 + 18 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917333 + 10.1245/s10434-023-13318-5 + 10.1245/s10434-023-13318-5 + + + + Raman SP, Horton KM, Fishman EK. Multimodality imaging of pancreatic cancer—computed tomography, magnetic resonance imaging, and positron emission tomography. Cancer J. 2012;18(6):511–22. https://doi.org/10.1097/PPO.0b013e318274a461 . + + 10.1097/PPO.0b013e318274a461 + 23187837 + + + + Gemenetzis G, Groot VP, Blair AB, et al. Incidence and risk factors for abdominal occult metastatic disease in patients with pancreatic adenocarcinoma. J Surg Oncol. 2018;118(8):1277–84. https://doi.org/10.1002/jso.25288 . + + 10.1002/jso.25288 + 30380143 + + + + Ge J, Li L, Ma Z, et al. A nomogram of preoperative predictors for occult metastasis in patients with PDAC during laparoscopic exploration. Gland Surg. 2021;10(1):279–89. https://doi.org/10.21037/gs-20-605 . + + 10.21037/gs-20-605 + 33633984 + 7882304 + + + + Maithel SK, Maloney S, Winston C, et al. Preoperative CA 19–9 and the yield of staging laparoscopy in patients with radiographically resectable pancreatic adenocarcinoma. Ann Surg Oncol. 2008;15(12):3512–20. https://doi.org/10.1245/s10434-008-0134-5 . + + 10.1245/s10434-008-0134-5 + 18781364 + + + + Conroy T, Desseigne F, Ychou M, et al. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med. 2011;364(19):1817–25. https://doi.org/10.1056/NEJMoa1011923 . + + 10.1056/NEJMoa1011923 + 21561347 + + + + Von Hoff DD, Ervin T, Arena FP, et al. Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N Engl J Med. 2013;369(18):1691–703. https://doi.org/10.1056/NEJMoa1304369 . + + 10.1056/NEJMoa1304369 + + + + +
+ + + 36917332 + + 2023 + 03 + 14 + +
+ + 1534-4681 + + + 2023 + Mar + 14 + + + Annals of surgical oncology + Ann Surg Oncol + + ASO Author Reflections: Mediastinoscope-Assisted Esophagectomy: An Innovative Minimally Invasive Technique for Esophageal Resection. + 10.1245/s10434-023-13296-8 + + + Dabsha + Anas + A + + Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA. + + + Surgical Oncology Department, National Cancer Institute, Cairo University, Cairo, Egypt. + + + + Elkharbotly + Ismail A M H + IAMH + + Surgical Oncology Department, National Cancer Institute, Cairo University, Cairo, Egypt. + + + General Surgery Department, Newham University Hospital, London, UK. + + + + Rahouma + Mohamed + M + + Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA. Mmr2011@med.cornell.edu. + + + Surgical Oncology Department, National Cancer Institute, Cairo University, Cairo, Egypt. Mmr2011@med.cornell.edu. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Ann Surg Oncol + 9420840 + 1068-9265 + + IM +
+ + + + 2023 + 02 + 10 + + + 2023 + 02 + 15 + + + 2023 + 3 + 14 + 12 + 18 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917332 + 10.1245/s10434-023-13296-8 + 10.1245/s10434-023-13296-8 + + + + Li J, Xu J, Zheng Y, Gao Y, He S, Li H, et al. Esophageal cancer: epidemiology, risk factors and screening. Chin J Cancer Res. 2021;33(5):535–47. + + 10.21147/j.issn.1000-9604.2021.05.01 + 34815628 + 8580797 + + + + Rahouma M, Harrison S, Kamel M, Nasar A, Lee B, Port J, et al. Consequences of refusing surgery for esophageal cancer: a national cancer database analysis. Ann Thorac Surg. 2018;106(5):1476–83. + + 10.1016/j.athoracsur.2018.06.030 + 30055137 + + + + Yoshida N, Yamamoto H, Baba H, Miyata H, Watanabe M, Toh Y, et al. Can minimally invasive esophagectomy replace open esophagectomy for esophageal cancer? Latest analysis of 24,233 esophagectomies from the Japanese National Clinical Database. Ann Surg. 2020;272(1):118. + + 10.1097/SLA.0000000000003222 + 30720501 + + + + Dabsha A, Elkharbotly IAMH, Yaghmour M, Badr A, Badie F, Khairallah S, et al. Novel mediastinoscope-assisted minimally invasive esophagectomy for esophageal cancer: a systematic review and meta-analysis. Ann Surg Oncol. 2023. https://doi.org/10.1245/s10434-023-13264-2 . + + 10.1245/s10434-023-13264-2 + 36820939 + + + + +
+ + + 36917334 + + 2023 + 03 + 14 + +
+ + 1534-4681 + + + 2023 + Mar + 14 + + + Annals of surgical oncology + Ann Surg Oncol + + Editorial: Preoperative Frailty Risk Assessment Prior to Esophagectomy, Where Are We? + 10.1245/s10434-023-13210-2 + + + Fay + K A + KA + + Department of Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA. + + + + Hasson + R M + RM + + Department of Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA. Rian.M.Hasson@Hitchcock.Org. + + + Geisel School of Medicine at Dartmouth, Hanover, NH, USA. Rian.M.Hasson@Hitchcock.Org. + + + The Dartmouth Institute for Health Policy and Clinical Practice, Hanover, NH, USA. Rian.M.Hasson@Hitchcock.Org. + + + + eng + + + 5P30CA023108 / UL1TR001086 + National Cancer Institute + + + + + Editorial + + + 2023 + 03 + 14 + +
+ + United States + Ann Surg Oncol + 9420840 + 1068-9265 + + IM +
+ + + + 2023 + 01 + 09 + + + 2023 + 01 + 25 + + + 2023 + 3 + 14 + 12 + 18 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917334 + 10.1245/s10434-023-13210-2 + 10.1245/s10434-023-13210-2 + + + + Yamashita K, Yamasaki M, Makino T, et al. Preoperative comprehensive geriatric assessment predicts postoperative risk in older patients with esophageal cancer. Ann Surg Oncol. 2022. https://doi.org/10.1245/s10434-022-12778-5 . + + 10.1245/s10434-022-12778-5 + 36539581 + + + + Daniels SL, Lee MJ, George J, et al. Prehabilitation in elective abdominal cancer surgery in older patients: a systematic review and meta-analysis. BJS Open. 2020;4(6):1022–41. + + 10.1002/bjs5.50347 + 32959532 + 7709363 + + + + Doganay E, Moorthy K. Prehabilitation for esophagectomy. J Thorac Dis. 2019;11(Suppl 5):S632–8. + + 10.21037/jtd.2019.02.12 + 31080639 + 6503267 + + + + Anandavadivelan P, Lagergren P. Cachexia in patients with oesophageal cancer. Nat Rev Clin Oncol. 2016;13:185–98. + + 10.1038/nrclinonc.2015.200 + 26573424 + + + + Wagner D, DeMarco MM, Amini N, et al. Role of frailty and sarcopenia in predicting outcomes among patients undergoing gastrointestinal surgery. World J Gastrointest Surg. 2016;8(1):27–40. + + 10.4240/wjgs.v8.i1.27 + 26843911 + 4724585 + + + + Fay KA, Maeder ME, Emond JA, et al. Residing in a food desert is associated with increased risk of readmission following esophagectomy for cancer. J Thorac Dis. 2022;14(6):1854–68. + + 10.21037/jtd-21-1637 + 35813712 + 9264063 + + + + +
+ + + 36917336 + + 2023 + 03 + 14 + +
+ + 1534-4681 + + + 2023 + Mar + 14 + + + Annals of surgical oncology + Ann Surg Oncol + + A Competing Risk Model Nomogram to Predict the Long-Term Prognosis of Lung Carcinoid. + 10.1245/s10434-023-13333-6 + + The prediction of long-term, cancer-specific survival of lung carcinoid remains controversial. We aimed to build a prognostic model by using competing-risk analysis to predict the long-term, cancer-specific survival of lung carcinoid patients. + Patients were retrospectively enrolled from the SEER database, and clinicopathological data were collected. Univariable and multivariable competing-risk analyses were conducted to identify prognostic factors. A competing-risk model and a nomogram were developed by using independent prognostic factors. The model was assessed by using concordance index and calibration curves. + A total of 2496 patients were enrolled, of which 267 (10.7%) died of diagnosed carcinoma; 316 (12.7%) died because of other reasons. The 5-year, 10-year, and 15-year cancer-specific survival of carcinoid patients were 91.35%, 86.60%, and 84.39%, respectively. Multivariable analysis demonstrated that increasing age, male, larger tumor size, higher N stage, M1, atypical carcinoid, and undergoing no surgery were independent risk factors. A competing-risk model based on the risk factors and a corresponding nomogram were developed. Concordance index of the developed model for 5-year, 10-year, and 15-year were 0.891, 0.856, 0.836 respectively in the training cohort and 0.876, 0.841, 0.819 respectively in the validation cohort after bootstrap adjustment. The calibration curves of 5-year, 10-year, and 15-year showed good agreement. + Increasing age, male, larger tumor size, higher N stage, M1, atypical carcinoid, and undergoing no surgery were independent risk factors. A competing risk model of excellent performance in predicting long-term survival was developed, and a nomogram was established. + © 2023. Society of Surgical Oncology. + + + + Wang + Tengyong + T + + Department of Thoracic Surgery and Institute of Thoracic Oncology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. + + + + Zhou + Jian + J + + Department of Thoracic Surgery and Institute of Thoracic Oncology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. + + + + Zheng + Quan + Q + + Department of Thoracic Surgery and Institute of Thoracic Oncology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. + + + + Wu + Dongsheng + D + + Department of Thoracic Surgery and Institute of Thoracic Oncology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. + + + + Lu + Tianyi + T + + West China School of Medicine, Sichuan University, Chengdu, China. + + + + Lin + Mingying + M + + West China School of Medicine, Sichuan University, Chengdu, China. + + + + Pu + Qiang + Q + + Department of Thoracic Surgery and Institute of Thoracic Oncology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. + + + + Mei + Jiandong + J + + Department of Thoracic Surgery and Institute of Thoracic Oncology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. + + + + Liu + Lunxu + L + http://orcid.org/0000-0003-3964-5378 + + Department of Thoracic Surgery and Institute of Thoracic Oncology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. lunxu_liu@aliyun.com. + + + + eng + + + ZYGD18021 + 1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University + + + + ZYJC18009 + 1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Ann Surg Oncol + 9420840 + 1068-9265 + + IM +
+ + + + 2022 + 12 + 28 + + + 2023 + 02 + 08 + + + 2023 + 3 + 14 + 12 + 18 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917336 + 10.1245/s10434-023-13333-6 + 10.1245/s10434-023-13333-6 + + + + Naalsund A, Rostad H, Strøm EH, Lund MB, Strand TE. Carcinoid lung tumors–incidence, treatment and outcomes: a population-based study. Eur J Cardiothorac Surg. 2011;39(4):565–9. + + 10.1016/j.ejcts.2010.08.036 + 20888248 + + + + Öberg K, Hellman P, Ferolla P, Papotti M. Neuroendocrine bronchial and thymic tumors: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2012;23(Suppl 7):vii120-3. + + 22997444 + + + + Travis WD, Brambilla E, Nicholson AG, et al. The 2015 World Health Organization classification of lung tumors: impact of genetic, clinical and radiologic advances since the 2004 classification. J Thorac Oncol. 2015;10(9):1243–60. + + 10.1097/JTO.0000000000000630 + 26291008 + + + + Dasari A, Shen C, Halperin D, et al. Trends in the incidence, prevalence, and survival outcomes in patients with neuroendocrine tumors in the United States. JAMA Oncol. 2017;3(10):1335–42. + + 10.1001/jamaoncol.2017.0589 + 28448665 + 5824320 + + + + Caplin ME, Baudin E, Ferolla P, et al. Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids. Ann Oncol. 2015;26(8):1604–20. + + 10.1093/annonc/mdv041 + 25646366 + + + + Yoon JY, Sigel K, Martin J, et al. Evaluation of the prognostic significance of TNM staging guidelines in lung carcinoid tumors. J Thorac Oncol. 2019;14(2):184–92. + + 10.1016/j.jtho.2018.10.166 + 30414942 + + + + Soldath P, Binderup T, Kjaer A, et al. Long-term survival and recurrence after resection of bronchopulmonary carcinoids: a single-center cohort study of 236 patients. Lung Cancer. 2021;156:109–16. + + 10.1016/j.lungcan.2021.04.010 + 33940543 + + + + Thakur S, Florisson D, Telianidis S, et al. Pulmonary carcinoid tumours: a multi-centre analysis of survival and predictors of outcome following sublobar, lobar, and extended pulmonary resections. Asian Cardiovasc Thorac Ann. 2021;29(6):532–40. + + 10.1177/02184923211010090 + 33853389 + + + + Janssen-Heijnen ML, Houterman S, Lemmens VE, Louwman MW, Maas HA, Coebergh JW. Prognostic impact of increasing age and co-morbidity in cancer patients: a population-based approach. Crit Rev Oncol Hematol. 2005;55(3):231–40. + + 10.1016/j.critrevonc.2005.04.008 + 15979890 + + + + Väisänen JA, Alho OP, Koivunen PT, Läärä E. Cause-specific mortality in patients with head and neck cancer: long-term follow-up of a population-based cohort from 1986 to 2012 accounting for competing risks. 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+ + + 36917337 + + 2023 + 03 + 14 + +
+ + 1534-4681 + + + 2023 + Mar + 14 + + + Annals of surgical oncology + Ann Surg Oncol + + Top Pancreatic Tumor Articles from 2021 to Inform Your Cancer Patients. + 10.1245/s10434-023-13277-x + + More than 10,000 publications about pancreatic cancer were found on PubMed during the past year. + To best inform patients with pancreatic cancer, the obvious, frequent questions asked during patient counseling when dealing with resectable pancreatic cancer, borderline resectable pancreatic cancer, and unresectable pancreatic cancer were considered. + The publications highlighted are comprehensive on the current management of neoadjuvant therapy for resectable pancreatic cancer, the addition of radiation to neoadjuvant therapy for borderline resectable pancreatic cancer, the utility of arterial resections in unresectable pancreatic cancer, and the role of minimally invasive approach to pancreatic cancer surgical therapy. + These articles are high yield and comprehensive review on key issues facing surgical oncologists who operate on pancreatic cancer. + © 2023. Society of Surgical Oncology. + + + + Hogg + Melissa E + ME + + Department of Surgery, NorthShore University HealthSystem, Evanston, IL, USA. MHogg@Northshore.org. + + + + Melstrom + Laleh G + LG + + City of Hope, Duarte, CA, USA. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Ann Surg Oncol + 9420840 + 1068-9265 + + IM +
+ + + + 2022 + 11 + 07 + + + 2023 + 02 + 12 + + + 2023 + 3 + 14 + 12 + 18 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917337 + 10.1245/s10434-023-13277-x + 10.1245/s10434-023-13277-x + + + + van Dam JL, Janssen QP, Besselink MG, et al. Neoadjuvant therapy or upfront surgery for resectable and borderline resectable pancreatic cancer: a meta-analysis of randomised controlled trials. Eur J Cancer. 2022;160:140–9. https://doi.org/10.1016/j.ejca.2021.10.023 . + + 10.1016/j.ejca.2021.10.023 + 34838371 + + + + Golcher H, Brunner TB, Witzigmann H, et al. Neoadjuvant chemoradiation therapy with gemcitabine/cisplatin and surgery versus immediate surgery in resectable pancreatic cancer: results of the first prospective randomized phase II trial. Strahlenther Onkol. 2015;191(1):7–16. https://doi.org/10.1007/s00066-014-0737-7 . + + 10.1007/s00066-014-0737-7 + 25252602 + + + + Casadei R, Di Marco M, Ricci C, et al. 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Ann Surg. 2018;268(2):215–22. https://doi.org/10.1097/SLA.0000000000002705 . + + 10.1097/SLA.0000000000002705 + 29462005 + + + + Motoi F, Kosuge T, Ueno H, et al. Randomized phase II/III trial of neoadjuvant chemotherapy with gemcitabine and S-1 versus upfront surgery for resectable pancreatic cancer (Prep-02/JSAP05). Jpn J Clin Oncol. 2019;49(2):190–4. https://doi.org/10.1093/jjco/hyy190 . + + 10.1093/jjco/hyy190 + 30608598 + + + + Versteijne E, Suker M, Groothuis K, et al. Preoperative chemoradiotherapy versus immediate surgery for resectable and borderline resectable pancreatic cancer: results of the Dutch randomized phase III PREOPANC trial. J Clin Oncol. 2020;38(16):1763–73. https://doi.org/10.1200/JCO.19.02274 . + + 10.1200/JCO.19.02274 + 32105518 + 8265386 + + + + Ghaneh P, Palmer D, Cicconi S, et al. ESPAC-5F: four arm, prospective, multicentre, international randomised phase II trial of immediate surgery compared with neoadjuvant gemcitabine plus capecitabine (GEMCAP) or FOLFIRINOX or chemoradiotherapy (CRT) in patients with borderline resectable pancreatic cancer. In: ASCO annual meeting. 2020. J Clin Oncol. 2020;38:4505. https://doi.org/10.1200/JCO.2020.38.15_suppl.4505 + + + Ahmad SA, Duong M, Sohal DPS, et al. Surgical outcome results from SWOG S1505: a randomized clinical trial of mFOLFIRINOX versus gemcitabine/nab-paclitaxel for perioperative treatment of resectable pancreatic ductal adenocarcinoma. Ann Surg. 2020;272(3):481–6. https://doi.org/10.1097/SLA.0000000000004155 . + + 10.1097/SLA.0000000000004155 + 32740235 + + + + Conroy T, Hammel P, Hebbar M, et al. FOLFIRINOX or gemcitabine as adjuvant therapy for pancreatic cancer. N Engl J Med. 2018;379(25):2395–406. https://doi.org/10.1056/NEJMoa1809775 . + + 10.1056/NEJMoa1809775 + 30575490 + + + + Labori KJ, Lassen K, Hoem D, et al. Neoadjuvant chemotherapy versus surgery first for resectable pancreatic cancer (Norwegian pancreatic cancer trial-1 (NorPACT-1))—study protocol for a national multicentre randomized controlled trial. BMC Surg. 2017;17(1):94. https://doi.org/10.1186/s12893-017-0291-1 . + + 10.1186/s12893-017-0291-1 + 28841916 + 6389186 + + + + Schwarz L, Vernerey D, Bachet JB, et al. Resectable pancreatic adenocarcinoma neo-adjuvant FOLF(IRIN)OX-based chemotherapy - a multicenter, non-comparative, randomized, phase II trial (PANACHE01-PRODIGE48 study) [published correction appears in BMC Cancer. 2020 Mar 3;20(1):168]. BMC Cancer. 2018;18(1):762. https://doi.org/10.1186/s12885-018-4663-4 . + + 10.1186/s12885-018-4663-4 + 30041614 + 6057099 + + + + Ferrone C. 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+ + + 36917339 + + 2023 + 03 + 14 + +
+ + 1534-6285 + + + 2023 + Mar + 14 + + + Current urology reports + Curr Urol Rep + + Advancing Urology Resident Surgical Autonomy. + 10.1007/s11934-023-01152-x + + This paper aims to survey current literature on urologic graduate medical education focusing on surgical autonomy. + Affording appropriate levels of surgical autonomy has a key role in the education of urologic trainees and perceived preparedness for independent practice. Recent studies in surgical resident autonomy have demonstrated a reduction in autonomy for trainees in recent years. Efforts to advance the state of modern surgical training include creation of targeted curricula, enhanced with use of surgical simulation, and structured feedback. Decline in surgical autonomy for urology residents may influence confidence after completion of their residency. Further study is needed into the declining levels of urology resident autonomy, how it affects urologists entering independent practice, and what interventions can advance autonomy in modern urologic training. + © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. + + + + Nguyen + Anh T + AT + http://orcid.org/0000-0003-0389-8971 + + Division of Urology Rutgers New Jersey Medical School, Newark, NJ, 07103, USA. anhtnguyen732@gmail.com. + + + + Anjaria + Devashish J + DJ + + East Orange Department of Surgery, Veteran Affairs New Jersey Healthcare System East Orange, East Orange, NJ, USA. + + + + Sadeghi-Nejad + Hossein + H + + East Orange Department of Surgery, Veteran Affairs New Jersey Healthcare System East Orange, East Orange, NJ, USA. + + + Hackensack University Medical Center, Hackensack, NJ, USA. + + + + eng + + Journal Article + Review + + + 2023 + 03 + 14 + +
+ + United States + Curr Urol Rep + 100900943 + 1527-2737 + + IM + + Autonomy + Graduate medical education + Surgical training + Urology residency + +
+ + + + 2023 + 02 + 22 + + + 2023 + 3 + 14 + 12 + 18 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917339 + 10.1007/s11934-023-01152-x + 10.1007/s11934-023-01152-x + + + + Coleman JJ, Esposito TJ, Rozycki GS, Feliciano DV. Early subspecialization and perceived competence in surgical training: are residents ready? J Am Coll Surg. 2013;216(4):764–71. discussion 71–3. + + + Bucholz EM, Sue GR, Yeo H, Roman SA, Bell RH Jr, Sosa JA. Our trainees’ confidence: results from a national survey of 4136 US general surgery residents. Arch Surg. 2011;146(8):907–14. + + 21844434 + 10.1001/archsurg.2011.178 + + + + Mattar SG, Alseidi AA, Jones DB, Jeyarajah DR, Swanstrom LL, Aye RW, et al. General surgery residency inadequately prepares trainees for fellowship: results of a survey of fellowship program directors. Ann Surg. 2013;258(3):440–9. + + 24022436 + 10.1097/SLA.0b013e3182a191ca + + + + Anderson TN, Payne DH, Dent DL, Kearse LE, Schmiederer IS, Korndorffer JR. Defining the deficit in us surgical training: the trainee’s perspective. J Am Coll Surg. 2021;232(4):623–7. + + 33385569 + 10.1016/j.jamcollsurg.2020.11.029 + + + + Hamawy KJ, Edgar L. Urology Milestones 2.0: the future looks bright. Curr Urol Rep. 2019;20(12):85. + + + Urology Milestones [Internet]. 2020 ACGME Available from: https://www.acgme.org/specialties/urology/milestones/ . + + + Khuri SF, Daley J, Henderson W, Hur K, Demakis J, Aust JB, et al. The Department of Veterans Affairs’ NSQIP: the first national, validated, outcome-based, risk-adjusted, and peer-controlled program for the measurement and enhancement of the quality of surgical care. National VA Surgical Quality Improvement Program. Ann Surg. 1998;228(4):491–507. + + + Itani KMF, DePalma RG, Schifftner T, Sanders KM, Chang BK, Henderson WG, et al. Surgical resident supervision in the operating room and outcomes of care in Veterans Affairs hospitals. 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+ + 1678-4405 + + + 2023 + Mar + 14 + + + Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] + Braz J Microbiol + + A new extracellular glutaminase and urease-free L-asparaginase from Meyerozyma guilliermondii. + 10.1007/s42770-023-00939-x + + L-Asparaginase (L-ASNase) is a potent chemotherapeutic drug employed to treat leukemia and lymphoma. Currently, L-ASNases for therapeutic use are obtained from Escherichia coli and Dickeya chrysanthemi (Erwinia chrysanthemi). Despite their therapeutic potential, enzymes from bacteria are subject to inducing immune responses, resulting in a higher number of side effects. Eukaryote producers, such as fungi, may provide therapeutic alternatives through enzymes that induce relatively less toxicity and immune responses. Additional expected benefits from yeast-derived enzymes include higher activity and stability in physiological conditions. This work describes the new potential therapeutic candidate L-ASNase from the yeast Meyerozyma guilliermondii. A statistical approach (full factorial central composite design) was used to optimize L-ASNase production, considering L-asparagine and glucose concentration, pH of the medium, and cultivation time as independent factors. In addition, the crude enzymes were biochemically characterized, in terms of temperature and optimal pH, thermostability, pH stability, and associated glutaminase or urease activities. Our results showed that enzyme production increased after supplementing a pH 4.0 medium with 1.0% L-asparagine and 0.5% glucose during 75 h of cultivation. Under these optimized conditions, L-ASNase production reached 26.01 U mL-1, which is suitable for scale-up studies. The produced L-ASNase exhibits maximal activity at 37 °C and pH 7.0 and is highly stable under physiological conditions. In addition, M. guilliermondii L-ASNase has no associated glutaminase or urease activities, demonstrating its potential as a promising antineoplastic agent. + © 2023. The Author(s) under exclusive licence to Sociedade Brasileira de Microbiologia. + + + + Ratuchne + Aline + A + + Departamento de Ciências Biológicas, Universidade Estadual Do Centro-Oeste, Camargo Varela de Sá Street, 03, Guarapuava, Paraná State, 85040-080, Brazil. + + + + Izidoro + Simone Cristine + SC + + Departamento de Ciências Biológicas, Universidade Estadual Do Centro-Oeste, Camargo Varela de Sá Street, 03, Guarapuava, Paraná State, 85040-080, Brazil. + + + + Beitel + Susan Michelz + SM + + Departamento de Ciências Biológicas, Universidade Estadual Do Centro-Oeste, Camargo Varela de Sá Street, 03, Guarapuava, Paraná State, 85040-080, Brazil. + + + + Lacerda + Lorena Tigre + LT + + Departamento de Biologia Geral E Aplicada, Universidade Estadual Paulista (UNESP), 24A Avenue, 1515, Rio Claro, São Paulo State, 13506-752, Brazil. + + + + Knob + Adriana + A + http://orcid.org/0000-0002-1239-2182 + + Departamento de Ciências Biológicas, Universidade Estadual Do Centro-Oeste, Camargo Varela de Sá Street, 03, Guarapuava, Paraná State, 85040-080, Brazil. knob@unicentro.br. + + + + eng + + + Grant. 443953/2014-7 + Conselho Nacional de Desenvolvimento Científico e Tecnológico + + + + Finance code 001 + Coordenação de Aperfeiçoamento de Pessoal de Nível Superior + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + Brazil + Braz J Microbiol + 101095924 + 1517-8382 + + IM + + Biochemical properties + Optimization + Therapeutic enzymes + Yeasts + +
+ + + + 2022 + 07 + 18 + + + 2023 + 02 + 22 + + + 2023 + 3 + 14 + 12 + 18 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917331 + 10.1007/s42770-023-00939-x + 10.1007/s42770-023-00939-x + + + + de la Fuente M, Lombardero L, Gómez-González A, Solari C, Angulo-Barturen I, Acera A, Vecino E, Astigarra E (2021) Enzyme therapy: current challenges and future perspectives. Int J Mol Sci 22:9181. https://doi.org/10.3390/ijms22179181 + + 10.3390/ijms22179181 + 34502086 + 8431097 + + + + Vellard M (2003) The enzyme as drug: application of enzymes as pharmaceuticals. Curr Opin Biotechnol 14:444–450. https://doi.org/10.1016/s0958-1669(3)00092-2 + + 10.1016/s0958-1669(3)00092-2 + 12943856 + + + + Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F (2021) Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. 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Biotechnol Genet Eng Rev 33:40–61. https://doi.org/10.1080/02648725.2017.1357294 + + 10.1080/02648725.2017.1357294 + 28766374 + + + + da Cunha MC, Aguilar JGS, de Melo RR, Nagamatsu ST, Ali F, de Castro RJS, Sato HH (2019) Fungal L-asparaginase: strategies for production and food applications. Food Res Int 126:108658. https://doi.org/10.1016/j.foodres.2019.108658 + + 10.1016/j.foodres.2019.108658 + 31732030 + + + + Brumano LP, da Silva FVS, Costa-Silva TA, Apolinário AC, Santos JHPM, Kleingesinds EK, Monteiro G, Rangel-Yagui CO, Benyahia B, Junior AP (2019) Development of L-asparaginase biobetters: current research status and review of the desirable quality profiles. Front Bioeng Biotechnol 10(6):212. https://doi.org/10.3389/fbioe.2018.00212 + + 10.3389/fbioe.2018.00212 + + + + Izadpanah F, Homaei A, Fernandes P, Javadpour S (2018) Marine microbial L-asparaginase: biochemistry, molecular approaches and applications in tumor therapy and in food industry. 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+ + + 36917340 + + 2023 + 03 + 14 + +
+ + 1534-6285 + + + 2023 + Mar + 14 + + + Current urology reports + Curr Urol Rep + + Single-Use Ureteroscopy and Environmental Footprint: Review of Current Evidence. + 10.1007/s11934-023-01154-9 + + Ureteroscopy is a well-established treatment modality for kidney and ureteric calculi in addition to playing a key role in upper tract cancer diagnostics. Traditional reusable flexible ureteroscopes are technologically advanced and expensive pieces of equipment that require repeat sterilisation and periodical repair. These issues have led to the development of single-use flexible ureteroscopes that are disposed of after each case. Whilst this may be advantageous in many respects, the environmental impact of such technology is yet to be fully determined. The aim of this review is to therefore identify and summarise the available literature concerning the environmental footprint of single-use ureteroscopy. + To identify the latest research on this topic, a systematic search of world literature was conducted using the Medline, Embase, and PsycINFO databases. PRISMA guidelines were followed and articles were assessed by all authors and relevant study results were included in a narrative format. Only one relevant article was identified and included. This study found that a single-use flexible ureteroscope (LithoVueTM by Boston Scientific) generated an equivalent amount of carbon dioxide per case to a contemporary reusable flexible ureteroscope. Literature concerning the environmental footprint of single-use ureteroscopy is worryingly lacking. No conclusions can be definitively drawn from a single study and further research is imperative given the global climate crisis and the significant contribution that healthcare services have to the environmental problem. + © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. + + + + Brown + George + G + http://orcid.org/0000-0002-6325-824X + + Department of Urology, University Hospital Southampton, Southampton, UK. george.brown13@nhs.net. + + + + Ong + Andrea + A + + Department of Urology, University Hospital Southampton, Southampton, UK. + + + + Juliebø-Jones + Patrick + P + + Department of Urology, Haukeland University Hospital, Bergen, Norway. + + + + Davis + Niall F + NF + + Department of Urology, Beaumont Hospital and Royal College of Surgeons in Ireland, Dublin, Ireland. + + + + Skolarikos + Andreas + A + + University of Athens, Athens, Greece. + + + + Somani + Bhaskar + B + + Department of Urology, University Hospital Southampton, Southampton, UK. + + + + eng + + Journal Article + Review + + + 2023 + 03 + 14 + +
+ + United States + Curr Urol Rep + 100900943 + 1527-2737 + + IM + + Carbon + Endourology + Environment + Kidney calculi + Single-use + Ureteroscopy + +
+ + + + 2023 + 02 + 28 + + + 2023 + 3 + 14 + 12 + 18 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917340 + 10.1007/s11934-023-01154-9 + 10.1007/s11934-023-01154-9 + + + + Papers of particular interest, published recently, have been highlighted as: • Of importance + + Pietropaolo A, Bres-Niewada E, Skolarikos A, Liatsikos E, Kallidonis P, Aboumarzouk O, Tailly T, Proietti S, Traxer O, Giusti G, Rukin N, Özsoy M, Talso M, Emre S, Emiliani E, Atis G, Somani B. Worldwide survey of flexible ureteroscopy practice: a survey from European Association of Urology sections of young academic urologists and uro-technology groups. Cent European J Urol. 2019;72(4):393–7. + + 32015909 + 6979553 + + + + Bahaee J, Plott J, Ghani K. Single-use flexible ureteroscopes: how to choose and what is around the corner? Curr Opin Urol. 2021;31(2):87–94. + + 10.1097/MOU.0000000000000852 + 33399370 + + + + Butticè S, Sener TE, Netsch C, Emiliani E, Pappalardo R, Magno C. LithoVue™: a new single-use digital flexible ureteroscope. Cent European J Urol. 2016;69(3):302–5. + + 27730000 + 5057057 + + + + Costello A, Abbas M, Allen A, Ball S, Bell S, Bellamy R, Friel S, Groce N, Johnson A, Kett M, Lee M, Levy C, Maslin M, McCoy D, McGuire B, Montgomery H, Napier D, Pagel C, Patel J, de Oliveira J, Redclift N, Rees H, Rogger D, Scott J, Stephenson J, Twigg J, Wolff J, Patterson C. Managing the health effects of climate change: Lancet and University College London Institute for Global Health Commission. Lancet. 2009;373(9676):1693–733. + + 10.1016/S0140-6736(09)60935-1 + 19447250 + + + + MacNeill A, Lillywhite R, Brown C. The impact of surgery on global climate: a carbon footprinting study of operating theatres in three health systems. Lancet Planet Health. 2017;1(9):e381–8. + + 10.1016/S2542-5196(17)30162-6 + 29851650 + + + + Sherman J, MacNeill A, Thiel C. Reducing pollution from the health care industry. JAMA. 2019;322(11):1043–4. + + 10.1001/jama.2019.10823 + 31373600 + + + + Page M, McKenzie J, Bossuyt P, Boutron I, Hoffmann T, Mulrow C, Shamseer L, Tetzlaff J, Akl E, Brennan S, Chou R, Glanville J, Grimshaw J, Hróbjartsson A, Lalu M, Li T, Loder E, Mayo-Wilson E, McDonald S, McGuinness L, Stewart L, Thomas J, Tricco A, Welch V, Whiting P, Moher D. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372: n71. + + 10.1136/bmj.n71 + 33782057 + 8005924 + + + + • Davis N, McGrath S, Quinlan M, Jack G, Lawrentschuk N, Bolton D. Carbon Footprint in flexible ureteroscopy: a comparative study on the environmental impact of reusable and single-use ureteroscopes. J Endourol. 2018;32(3):214-217. The only study that has looked into the environmental impact of single-use ureteroscopy compared to reusable equipment. This study is fully examined in the Results section. + + + Dragos L, Somani B, Keller E, De Coninck V, Herrero M, Kamphuis G, Bres-Niewada E, Sener E, Doizi S, Wiseman O, Traxer O. Characteristics of current digital single-use flexible ureteroscopes versus their reusable counterparts: an in-vitro comparative analysis. Transl Androl Urol. 2019;8(Suppl 4):S359–70. + + 10.21037/tau.2019.09.17 + 31656742 + 6790413 + + + + • Rindorf D, Tailly T, Kamphuis G, Larsen S, Somani B, Traxer O, Koo K. Repair rate and associated costs of reusable flexible ureteroscopes: a systematic review and meta-analysis. Eur Urol Open Sci. 2022;37:64-72. An important paper looking at association of repair rates and cost of reusable scopes. + + + Hennessey D, Fojecki G, Papa N, Lawrentschuk N, Bolton D. Single-use disposable digital flexible ureteroscopes: an ex vivo assessment and cost analysis. BJU Int. 2018;121(Suppl 3):55–61. + + 10.1111/bju.14235 + 29656467 + + + + Martin C, McAdams S, Abdul-Muhsin H, Lim V, Nunez-Nateras R, Tyson M, Humphreys M. The economic implications of a reusable flexible digital ureteroscope: a cost-benefit analysis. J Urol. 2017;197(3 Pt 1):730–5. + + 10.1016/j.juro.2016.09.085 + 27693449 + + + + Hogan D, Rauf H, Kinnear N, Hennessey D. The carbon footprint of single-use flexible cystoscopes compared with reusable cystoscopes. J Endourol. 2022.  https://doi.org/10.1089/end.2021.0891 . Epub ahead of print. + + + Rizan C, Bhutta MF. Re: The carbon footprint of single-use flexible cystoscopes compared to reusable cystoscopes: methodological flaws led to the erroneous conclusion that single-use is “better”. J Endourol. 2022.  https://doi.org/10.1089/end.2022.0482 . Epub ahead of print. + + + Le N, Hernandez L, Vakil N, Guda N, Patnode C, Jolliet O. Environmental and health outcomes of single-use versus reusable duodenoscopes. Gastrointest Endosc. 2022;S0016-5107(22)01765-5.  https://doi.org/10.1016/j.gie.2022.06.014 . Epub ahead of print. + + + Namburar S, von Renteln D, Damianos J, Bradish L, Barrett J, Aguilera-Fish A, Cushman-Roisin B, Pohl H. Estimating the environmental impact of disposable endoscopic equipment and endoscopes. Gut. 2022;71(7):1326–31. + + 10.1136/gutjnl-2021-324729 + 34853058 + + + + Sørensen B, Grüttner H. Comparative study on environmental impacts of reusable and single-use bronchoscopes. Am J Environ Prot. 2018;7(4):55–62. + + + Mazzucchi E, Marchini G, Berto F, Denstedt J, Danilovic A, Vicentini F, Torricelli F, Battagello C, Srougi M, Nahas W. Single-use flexible ureteroscopes: update and perspective in developing countries. A narrative review. Int Braz J Urol. 2022;48(3):456-467. + + + Marchini G, Batagello C, Monga M, Torricelli F, Vicentini F, Danilovic A, Srougi M, Nahas W, Mazzucchi E. In vitro evaluation of single-use digital flexible ureteroscopes: a practical comparison for a patient-centered approach. J Endourol. 2018;32(3):184–91. + + 10.1089/end.2017.0785 + 29239229 + + + + Talso M, Proietti S, Emiliani E, Gallioli A, Dragos L, Orosa A, Servian P, Barreiro A, Giusti G, Montanari E, Somani B, Traxer O. Comparison of flexible ureterorenoscope quality of vision: an in vitro study. J Endourol. 2018;32(6):523–8. + + 10.1089/end.2017.0838 + 29562765 + + + + Baboudjian M, Gondran-Tellier B, Abdallah R, Tadrist A, Sichez P, Akiki A, Gaillet S, Delaporte V, Karsenty G, Lechevallier E, Boissier R. Single use and reusable flexible ureteroscopies for the treatment of urinary stones: a comparative study of perioperative complications. Prog Urol. 2021;31(6):368–73. + + 10.1016/j.purol.2020.11.014 + 33461865 + + + + Talso M, Goumas I, Kamphuis G, Dragos L, Tefik T, Traxer O, Somani B. Reusable flexible ureterorenoscopes are more cost-effective than single-use scopes: results of a systematic review from PETRA Uro-group. Transl Androl Urol. 2019;8(Suppl 4):S418–25. + + 10.21037/tau.2019.06.13 + 31656747 + 6790417 + + + + Wright A, Rukin N, Somani B. Ureteroscopy and stones: current status and future expectations. World J Nephrol. 2014;3(4):243–8. + + 10.5527/wjn.v3.i4.243 + 25374818 + 4220357 + + + + Somani B, Robertson A, Kata S. Decreasing the cost of flexible ureterorenoscopic procedures. Urology. 2011;78(3):528–30. + + 10.1016/j.urology.2010.12.073 + 21459421 + + + + + +
+ + + 36917338 + + 2023 + 03 + 14 + +
+ + 1534-4681 + + + 2023 + Mar + 14 + + + Annals of surgical oncology + Ann Surg Oncol + + ASO Visual Abstract: Reappraisal of Tumor Deposit as a Prognostic Factor in Pancreatic Cancer. + 10.1245/s10434-023-13165-4 + + + Hua + Jie + J + + Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China. + + + Department of Oncology, Fudan University Shanghai Medical College, Shanghai, China. + + + Shanghai Pancreatic Cancer Institute, Shanghai, China. + + + Pancreatic Cancer Institute, Fudan University, Shanghai, China. + + + + Xu + Jin + J + + Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China. + + + Department of Oncology, Fudan University Shanghai Medical College, Shanghai, China. + + + Shanghai Pancreatic Cancer Institute, Shanghai, China. + + + Pancreatic Cancer Institute, Fudan University, Shanghai, China. + + + + Liang + Chen + C + + Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China. + + + Department of Oncology, Fudan University Shanghai Medical College, Shanghai, China. + + + Shanghai Pancreatic Cancer Institute, Shanghai, China. + + + Pancreatic Cancer Institute, Fudan University, Shanghai, China. + + + + Meng + Qingcai + Q + + Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China. + + + Department of Oncology, Fudan University Shanghai Medical College, Shanghai, China. + + + Shanghai Pancreatic Cancer Institute, Shanghai, China. + + + Pancreatic Cancer Institute, Fudan University, Shanghai, China. + + + + Zhang + Bo + B + + Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China. + + + Department of Oncology, Fudan University Shanghai Medical College, Shanghai, China. + + + Shanghai Pancreatic Cancer Institute, Shanghai, China. + + + Pancreatic Cancer Institute, Fudan University, Shanghai, China. + + + + Yu + Xianjun + X + + Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China. + + + Department of Oncology, Fudan University Shanghai Medical College, Shanghai, China. + + + Shanghai Pancreatic Cancer Institute, Shanghai, China. + + + Pancreatic Cancer Institute, Fudan University, Shanghai, China. + + + + Wang + Wei + W + + Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China. wangwei@fudanpci.org. + + + Department of Oncology, Fudan University Shanghai Medical College, Shanghai, China. wangwei@fudanpci.org. + + + Shanghai Pancreatic Cancer Institute, Shanghai, China. wangwei@fudanpci.org. + + + Pancreatic Cancer Institute, Fudan University, Shanghai, China. wangwei@fudanpci.org. + + + + Shi + Si + S + + Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China. shisi@fudanpci.org. + + + Department of Oncology, Fudan University Shanghai Medical College, Shanghai, China. shisi@fudanpci.org. + + + Shanghai Pancreatic Cancer Institute, Shanghai, China. shisi@fudanpci.org. + + + Pancreatic Cancer Institute, Fudan University, Shanghai, China. shisi@fudanpci.org. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Ann Surg Oncol + 9420840 + 1068-9265 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 18 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917338 + 10.1245/s10434-023-13165-4 + 10.1245/s10434-023-13165-4 + + +
+ + + 36917342 + + 2023 + 03 + 14 + +
+ + 1432-1459 + + + 2023 + Mar + 14 + + + Journal of neurology + J Neurol + + Split-elbow sign in the PRO-ACT and Southern Italy ALS cohorts: a potential marker of disease severity and lower motor neuron involvement? + 10.1007/s00415-023-11660-y + + Split phenomena in ALS refers to the preferential dysfunction of some groups of muscles over others. The split-elbow sign (SE) is characterized by the predominant weakness of the biceps compared to the triceps, but available results are conflicting. + To evaluate the prevalence of the SE in two independent cohorts: the randomized controlled trial-based PRO-ACT cohort (n = 500) and a monocentric cohort of patients with ALS from Southern Italy (n = 144); to investigate the demographic and clinical variables associated with the SE sign. + Wilcoxon signed-rank test was used to compare biceps with triceps power in the same limb measured by hand-held dynamometry in the PRO-ACT cohort and Medical Research Council (MRC) in our cohort. Each limb was considered independently and not paired within the same individual. The arm where the triceps was stronger than the biceps was defined SE + , whereas the arm where the biceps was stronger than the triceps was considered SE-. A backward stepwise multivariate logistic regression was used to analyze the relationship between clinical and demographic variables and SE. PENN Upper Motor Neuron and Devine scales were used to evaluate the different upper (UMN) and lower (LMN) motor neuron impairments between the SE + and SE- arms. + In both cohorts, the biceps were on average stronger than the triceps, and the SE sign was present in 41% of the PRO-ACT cohort and just 30% of the Southern Italy cohort. The multivariate logistic regression revealed that older age (OR: 1.45; p = 0.01), male gender (OR: 1.55; p = 0.002), spinal onset (OR: 1.59; p = 0.007), and higher disease severity (OR: 1.70; p = 0.001) were significant predictors of the SE sign in the PRO-ACT cohort. Conversely, in Southern Italy patients, only a lower ALSFRS-R score was a significant determinant of the SE (OR: 8.47; p = 0.008). Finally, SE + arms exhibited a significantly higher median Devine sub-score compared to SE- [1 vs 0, p = < 0.05], while arms SE- showed a significantly higher median PUMNS sub-score [2 vs 0; p = < 0.05)]. + In our study, most patients with ALS do not show SE. Patients with SE are more likely older, males, with spinal onset, a higher degree of disease severity, and predominant and wider LMN impairment. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany. + + + + Zoccolella + Stefano + S + http://orcid.org/0000-0003-4037-7630 + + Operative Unit of Neurology, San Paolo, Hospital, ASL Bari, Via Caposcardicchio, Bari, Italy. stefzoc@hotmail.it. + + + Center for Neurodegenerative Diseases and the Aging Brain, University of Bari Aldo Moro at Pia Fondazione "Card. G. Panico", Tricase, Italy. stefzoc@hotmail.it. + + + + Milella + Giammarco + G + + Department of Translational Biomedicine and Neurosciences (DiBraiN), University of Bari Aldo Moro, Bari, Italy. + + + + Giugno + Alessia + A + + Center for Neurodegenerative Diseases and the Aging Brain, University of Bari Aldo Moro at Pia Fondazione "Card. G. Panico", Tricase, Italy. + + + + Urso + Daniele + D + + Center for Neurodegenerative Diseases and the Aging Brain, University of Bari Aldo Moro at Pia Fondazione "Card. G. Panico", Tricase, Italy. + + + + Tamburrino + Ludovica + L + + Center for Neurodegenerative Diseases and the Aging Brain, University of Bari Aldo Moro at Pia Fondazione "Card. G. Panico", Tricase, Italy. + + + + Nigro + Salvatore + S + + Center for Neurodegenerative Diseases and the Aging Brain, University of Bari Aldo Moro at Pia Fondazione "Card. G. Panico", Tricase, Italy. + + + + Gnoni + Valentina + V + + Center for Neurodegenerative Diseases and the Aging Brain, University of Bari Aldo Moro at Pia Fondazione "Card. G. Panico", Tricase, Italy. + + + + Filardi + Marco + M + + Center for Neurodegenerative Diseases and the Aging Brain, University of Bari Aldo Moro at Pia Fondazione "Card. G. Panico", Tricase, Italy. + + + + Logroscino + Giancarlo + G + + Center for Neurodegenerative Diseases and the Aging Brain, University of Bari Aldo Moro at Pia Fondazione "Card. G. Panico", Tricase, Italy. + + + Department of Translational Biomedicine and Neurosciences (DiBraiN), University of Bari Aldo Moro, Bari, Italy. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + J Neurol + 0423161 + 0340-5354 + + IM + + Amyotrophic lateral sclerosis + Prognosis + Split phenomena + Split-elbow + +
+ + + + 2023 + 01 + 28 + + + 2023 + 03 + 02 + + + 2023 + 03 + 01 + + + 2023 + 3 + 14 + 12 + 18 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917342 + 10.1007/s00415-023-11660-y + 10.1007/s00415-023-11660-y + + + + Kiernan MC, Vucic S, Cheah BC et al (2011) Amyotrophic lateral sclerosis. Lancet Lond Engl 377:942–955. https://doi.org/10.1016/S0140-6736(10)61156-7 + + 10.1016/S0140-6736(10)61156-7 + + + + Kuwabara S, Sonoo M, Komori T et al (2008) Dissociated small hand muscle atrophy in amyotrophic lateral sclerosis: frequency, extent, and specificity. Muscle Nerve 37:426–430. https://doi.org/10.1002/mus.20949 + + 10.1002/mus.20949 + 18236469 + + + + Menon P, Bae JS, Mioshi E et al (2013) Split-hand plus sign in ALS: differential involvement of the flexor pollicis longus and intrinsic hand muscles. 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+ + + 36917341 + + 2023 + 03 + 14 + +
+ + 1573-7438 + + 55 + 2 + + 2023 + Mar + 14 + + + Tropical animal health and production + Trop Anim Health Prod + + Effects of palm kernel cake on nutrient utilization and performance of grazing and confined cattle: a meta-analysis. + + 110 + + 10.1007/s11250-023-03530-6 + + A meta-analysis was conducted to evaluate the effects of dietary palm kernel cake inclusion (PKCInclusion) on the nutrient intake and digestibility, as well as on the performance of cattle under grazing and confined systems. Additionally, potential maximum safe levels (MSL) for PKCInclusion were explored for cattle under those systems using a broken-line approach. Overall, 22 studies for 85 treatment means and 747 experimental units were included in the dataset used for the meta-analysis in which, quantitative responses to increasing PKCInclusion levels were fitted using a mixed model, considering the study as a random effect. Additionally, all studies tested a treatment without the inclusion of PKC (PKCInclusion = 0 g/kg DM) in the concentrate and total mixed ration fed to grazing and confined animals, respectively. In grazing animals, intake, and digestibility of dry matter (DM), as well as intake of total digestible nutrient (TDN) and digestibility of crude protein (CP) decreased linearly (P < 0.01) as PKCInclusion increased. Conversely, the intake and digestibility of neutral detergent fiber (NDF) increased linearly (P < 0.01). Additionally, the intake of CP showed a quadratic decreasing pattern (P < 0.01) with the increase in dietary PKCInclusion. In confined animals, intake of DM, CP, NDF, and TDN revealed quadratic patterns (P < 0.01) as PKCInclusion increased. The digestibility of DM, CP, NDF, as well as TDN concentration showed a linear decreasing pattern (P < 0.05) as PKCInclusion increased. For performance, data revealed that average daily gain (ADG) decreased linearly (P < 0.01) in grazing and confined animals with the increase in PKCInclusion. Feed efficiency (FE) decreased linearly (P < 0.01) in grazing animals, whereas it showed a linear increase (P < 0.05) in confined animals. Exploration of the quadratic relationships of intake of DM, CP, NDF, and TDN with PKCInclusion in confined animals revealed MSL values for PKC ranging from 85.56 ± 14.2 to 126.4 ± 14.7 g PKC/kg DM. In grazing animals, exploration of the quadratic relationship of intake of CP with PKCInclusion, revealed an MSL value of 96.23 ± 9.01 g PKC/kg DM. In conclusion, data revealed that the use of PKC in both confined and grazing systems reduces the nutrient utilization and performance of cattle in a dose-dependent manner without a maximum safe level that does not reduce animal performance. + © 2023. The Author(s), under exclusive licence to Springer Nature B.V. + + + + Vargas + Julián Andrés Castillo + JAC + http://orcid.org/0000-0001-5163-5127 + + Department of Animal Science, Federal Rural University of the Amazon, 68515-000, Parauapebas, Pará, Brazil. jcfcav@gmail.com. + + + + Mezzomo + Rafael + R + + Department of Animal Science, Federal Rural University of the Amazon, 68515-000, Parauapebas, Pará, Brazil. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Trop Anim Health Prod + 1277355 + 0049-4747 + + IM + + Digestibility + Intake + Management system + Oil seed press cake + Quantitative review + Ruminant + +
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+ + + 36917344 + + 2023 + 03 + 14 + +
+ + 1432-2218 + + + 2023 + Mar + 14 + + + Surgical endoscopy + Surg Endosc + + Understanding fluorescence time curves during ileal pouch-anal anastomosis with or without vascular ligation. + 10.1007/s00464-023-09921-y + + Intraoperative indocyanine green fluorescence angiography (ICG-FA) may be of added value during pouch surgery, in particular after vascular ligations as lengthening maneuver. The aim was to determine quantitative perfusion parameters within the efferent/afferent loop and explore the impact of vascular ligation. Perfusion parameters were also compared in patients with and without anastomotic leakage (AL). + All consenting patients that underwent FA-guided ileal pouch-anal anastomosis (IPAA) between July 2020 and December 2021 were included. After intravenous bolus injection of 0.1 mg/kg ICG, the near-infrared camera (Stryker Aim 1688) registered the fluorescence intensity over time. Quantitative analysis of ICG-FA from standardized regions of interests on the pouch was performed using software. Fluorescence parameters were extracted for inflow (T0, Tmax, Fmax, slope, Time-to-peak) and outflow (T90% and T80%). Change of management related to FA findings and AL rates were recorded. + Twenty-one patients were included, three patients (14%) required vascular ligation to obtain additional length, by ligating terminal ileal branches in two and the ileocolic artery (ICA) in one patient. In nine patients the ICA was already ligated during subtotal colectomy. ICG-FA triggered a change of management in 19% of patients (n = 4/21), all of them had impaired vascular supply (ligated ileocolic/ terminal ileal branches). Overall, patients with intact vascular supply had similar perfusion patterns for the afferent and efferent loop. Pouches with ICA ligation had longer Tmax in both afferent as efferent loop than pouches with intact ICA (afferent 51 and efferent 53 versus 41 and 43 s respectively). Mean slope of the efferent loop diminished in ICA ligated patients 1.5(IQR 0.8-4.4) versus 2.2 (1.3-3.6) in ICA intact patients. + Quantitative analysis of ICG-FA perfusion during IPAA is feasible and reflects the ligation of the supplying vessels. + © 2023. The Author(s). + + + + Joosten + J J + JJ + http://orcid.org/0000-0001-6381-8182 + + Department of Surgery, Amsterdam University Medical Centres (UMC), Academic Medical Centre (AMC), Postbox 22660, 1100 DD, Amsterdam, The Netherlands. + + + Cancer Center Amsterdam, Imaging and Biomarkers, Amsterdam, The Netherlands. + + + Department of Surgery, Amsterdam UMC Location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. + + + + Slooter + M D + MD + + Department of Radiology, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands. + + + Department of Surgery, Amsterdam UMC Location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. + + + + van den Elzen + R M + RM + + Cancer Center Amsterdam, Imaging and Biomarkers, Amsterdam, The Netherlands. + + + Department of Biomedical Engineering, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands. + + + Department of Surgery, Amsterdam UMC Location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. + + + + Bloemen + P R + PR + + Cancer Center Amsterdam, Imaging and Biomarkers, Amsterdam, The Netherlands. + + + Department of Biomedical Engineering, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands. + + + Department of Surgery, Amsterdam UMC Location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. + + + + Laméris + W + W + + Department of Surgery, Amsterdam University Medical Centres (UMC), Academic Medical Centre (AMC), Postbox 22660, 1100 DD, Amsterdam, The Netherlands. + + + Cancer Center Amsterdam, Imaging and Biomarkers, Amsterdam, The Netherlands. + + + Department of Surgery, Amsterdam UMC Location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. + + + + de Bruin + D M + DM + + Cancer Center Amsterdam, Imaging and Biomarkers, Amsterdam, The Netherlands. + + + Department of Biomedical Engineering, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands. + + + Department of Surgery, Amsterdam UMC Location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. + + + + Bemelman + W A + WA + + Department of Surgery, Amsterdam University Medical Centres (UMC), Academic Medical Centre (AMC), Postbox 22660, 1100 DD, Amsterdam, The Netherlands. + + + Cancer Center Amsterdam, Imaging and Biomarkers, Amsterdam, The Netherlands. + + + Department of Surgery, Amsterdam UMC Location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. + + + + Hompes + R + R + + Department of Surgery, Amsterdam University Medical Centres (UMC), Academic Medical Centre (AMC), Postbox 22660, 1100 DD, Amsterdam, The Netherlands. r.hompes@amsterdamumc.nl. + + + Cancer Center Amsterdam, Imaging and Biomarkers, Amsterdam, The Netherlands. r.hompes@amsterdamumc.nl. + + + Department of Surgery, Amsterdam UMC Location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. r.hompes@amsterdamumc.nl. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Surg Endosc + 8806653 + 0930-2794 + + IM + + Anastomotic leakage + Fluorescence angiography (FA) + Fluorescence time curves + Ileal pouch-anal anastomosis (IPAA) + Indocyanine green (ICG) + Vascular ligation + +
+ + + + 2022 + 12 + 21 + + + 2023 + 01 + 28 + + + 2023 + 3 + 14 + 12 + 18 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917344 + 10.1007/s00464-023-09921-y + 10.1007/s00464-023-09921-y + + + + Oresland T, Bemelman WA, Sampietro GM, Spinelli A, Windsor A, Ferrante M et al (2015) European evidence based consensus on surgery for ulcerative colitis. J Crohns Colitis 9(1):4–25 + + 10.1016/j.crohns.2014.08.012 + 25304060 + + + + Fazio VW, Kiran RP, Remzi FH, Coffey JC, Heneghan HM, Kirat HT et al (2013) Ileal pouch anal anastomosis: analysis of outcome and quality of life in 3707 patients. Ann Surg 257(4):679–685 + + 10.1097/SLA.0b013e31827d99a2 + 23299522 + + + + Sahami S, Buskens CJ, Fadok TY, Tanis PJ, de Buck van Overstraeten A, Wolthuis AM, et al (2016) Defunctioning ileostomy is not associated with reduced leakage in proctocolectomy and ileal pouch anastomosis surgeries for IBD. J Crohn's Colitis 10(7):779–785 + + + Reijntjes MA, Joosten JJ, Hompes R, Bemelman WA (2021) Additional lengthening measures and perfusion assessment during pouch surgery—a video vignette. Colorectal Dis 23(6):1599 + + 10.1111/codi.15641 + 33738920 + + + + Shen R, Zhang Y, Wang T (2018) Indocyanine green fluorescence angiography and the incidence of anastomotic leak after colorectal resection for colorectal cancer: a meta-analysis. Dis Colon Rectum 61(10):1228–1234 + + 10.1097/DCR.0000000000001123 + 30192332 + + + + Alekseev M, Rybakov E, Shelygin Y, Chernyshov S, Zarodnyuk I (2020) A study investigating the perfusion of colorectal anastomoses using fluorescence angiography: results of the FLAG randomized trial. Colorectal Dis 22(9):1147–1153 + + 10.1111/codi.15037 + 32189424 + + + + Slooter MD, van der Does de Willebois EML, Joosten JJ, Reijntjes MA, Buskens CJ, Tanis PJ et al (2022) Fluorescence perfusion assessment of vascular ligation during ileal pouch-anal anastomosis. Tech Coloproctol. https://doi.org/10.1007/s10151-022-02666-1 + + 10.1007/s10151-022-02666-1 + 36129594 + 10008239 + + + + Spinelli A, Carvello M, Kotze PG, Maroli A, Montroni I, Montorsi M et al (2019) Ileal pouch-anal anastomosis with fluorescence angiography: a case-matched study. Colorectal Dis 21(7):827–832 + + 30873703 + + + + Hardy NP, Dalli J, Khan MF, Andrejevic P, Neary PM, Cahill RA (2021) Inter-user variation in the interpretation of near infrared perfusion imaging using indocyanine green in colorectal surgery. Surg Endosc 35(12):7074–7081 + + 10.1007/s00464-020-08223-x + 33398567 + + + + Lutken CD, Achiam MP, Osterkamp J, Svendsen MB, Nerup N (2021) Quantification of fluorescence angiography: toward a reliable intraoperative assessment of tissue perfusion—a narrative review. Langenbecks Arch Surg 406(2):251–259 + + 10.1007/s00423-020-01966-0 + 32821959 + + + + Joosten JJ, Reijntjes MA, Slooter MD, Duijvestein M, Buskens CJ, Bemelman WA et al (2021) Fluorescence angiography after vascular ligation to make the ileo-anal pouch reach. Tech Coloproctol 25(7):875–878 + + 10.1007/s10151-021-02447-2 + 33993370 + 8187171 + + + + Agha RA, Sohrabi C, Mathew G, Franchi T, Kerwan A, O’Neill N et al (2020) The PROCESS 2020 Guideline: Updating Consensus Preferred Reporting Of CasESeries in Surgery (PROCESS) Guidelines. Int J Surg 84:231–235 + + 10.1016/j.ijsu.2020.11.005 + 33189880 + + + + Zittan E, Wong-Chong N, Ma GW, McLeod RS, Silverberg MS, Cohen Z (2016) Modified two-stage ileal pouch-anal anastomosis results in lower rate of anastomotic leak compared with traditional two-stage surgery for ulcerative colitis. J Crohns Colitis 10(7):766–772 + + 10.1093/ecco-jcc/jjw069 + 26951468 + + + + Elliott JT, Addante RR, Slobogean GP, Jiang SD, Henderson ER, Pogue BW et al (2020) Intraoperative fluorescence perfusion assessment should be corrected by a measured subject-specific arterial input function. J Biomed Opt 25(6):066002 + + 10.1117/1.JBO.25.6.066002 + 32519522 + 7282620 + + + + Gardenbroek TJ, Musters GD, Buskens CJ, Ponsioen CY, D’Haens GR, Dijkgraaf MG et al (2015) Early reconstruction of the leaking ileal pouch-anal anastomosis: a novel solution to an old problem. Colorectal Dis 17(5):426–432 + + 10.1111/codi.12867 + 25512241 + + + + Ris F, Liot E, Buchs NC, Kraus R, Ismael G, Belfontali V et al (2018) Multicentre phase II trial of near-infrared imaging in elective colorectal surgery. Br J Surg 105(10):1359–1367 + + 10.1002/bjs.10844 + 29663330 + 6099466 + + + + Spinelli A, Cantore F, Kotze PG, David G, Sacchi M, Carvello M (2017) Fluorescence angiography during transanal trans-stomal proctectomy and ileal pouch anal anastomosis: a video vignette. Colorectal Dis. https://doi.org/10.1111/codi.13992 + + 10.1111/codi.13992 + 29247480 + + + + +
+ + + 36917345 + + 2023 + 03 + 14 + +
+ + 1435-1463 + + + 2023 + Mar + 14 + + + Journal of neural transmission (Vienna, Austria : 1996) + J Neural Transm (Vienna) + + Arm swing deviations in patients with Parkinson's disease at different gait velocities. + 10.1007/s00702-023-02619-4 + + Asymmetry of arm swing (AS) has been described as a characteristic of normal physiological gait. In patients with Parkinson's disease (PWPD), a one-sided reduction of AS can occur already as a prodromal symptom. There is limited evidence regarding AS in PWPD, but a growing interest in AS as a focus of exercise therapy. The differences of AS between 32 healthy subjects (HS) and 36 mildly-to-moderately impaired PWPD were assessed in overground walking at various gait speeds. Assessments were carried out with a sensor-based gait measurement system over a 40 m walk in very slow, slow, preferred, fast, and very fast gait speed. Longitudinal and AS kinematics were compared with ANOVA function and regression analysis. PWPD exhibited a one-sided reduction of AS compared to HS at normal, fast, and very fast walking. AS coordination, representing the timing of reciprocity of right and left AS, was reduced in PWPD in very slow and normal walking. With respect to leg movements, PWPD exhibited an increase in stride time variability in very slow gait. There were no group differences for cadence, stride length, and gait velocity. This study informs about the kinematics of AS at various gait velocities ranging from very slow to very fast in mildly-to-moderately impaired PWPD. Reduced one-sided AS can be considered as a very early sign of parkinsonian gait disturbance that precedes alterations of locomotive leg movements and improves at faster gait speeds. + © 2023. The Author(s). + + + + Mainka + Stefan + S + http://orcid.org/0000-0002-6970-7333 + + Movement Disorder Clinic, Parkinsonklinik, Str. n. Fichtenwalde 16, 14547, Beelitz-Heilstätten, Germany. mainka@kliniken-beelitz.de. + + + + Lauermann + Maximilian + M + + Faculty of Human Sciences, University of Potsdam, Potsdam, Germany. + + + + Ebersbach + Georg + G + http://orcid.org/0000-0003-3403-6987 + + Movement Disorder Clinic, Parkinsonklinik, Str. n. Fichtenwalde 16, 14547, Beelitz-Heilstätten, Germany. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Austria + J Neural Transm (Vienna) + 9702341 + 0300-9564 + + IM + + Arm swing + Gait velocity + Parkinson’s disease + Walking + +
+ + + + 2022 + 12 + 30 + + + 2023 + 03 + 06 + + + 2023 + 3 + 14 + 12 + 18 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917345 + 10.1007/s00702-023-02619-4 + 10.1007/s00702-023-02619-4 + + + + Boonstra TA, Van Der Kooij H, Munneke M, Bloem BR (2008) Gait disorders and balance disturbances in Parkinson’s disease: clinical update and pathophysiology. Curr Opin Neurol 21:461–471 + + 10.1097/WCO.0b013e328305bdaf + 18607208 + + + + Breek JC, Hamming JF, De Vries J et al (2002) The impact of walking impairment, cardiovascular risk factors, and comorbidity on quality of life in patients with intermittent claudication. J Vasc Surg 36:94–99. https://doi.org/10.1067/mva.2002.124369 + + 10.1067/mva.2002.124369 + 12096264 + + + + Bruening HG (2020) Schrittfrequenz und Schwingungsweite der Arme beim Gehen. unpublished working paper + + + Di Lazzaro G, Ricci M, Saggio G et al (2021) Technology-based therapy-response and prognostic biomarkers in a prospective study of a de novo Parkinson’s disease cohort. Npj Park Dis 7:1–7. https://doi.org/10.1038/s41531-021-00227-1 + + 10.1038/s41531-021-00227-1 + + + + Flachenecker F, Gaßner H, Hannik J et al (2020) Objective sensor-based gait measures reflect motor impairment in multiple sclerosis patients: Reliability and clinical validation of a wearable sensor device. Mult Scler Relat Disord. https://doi.org/10.1016/j.msard.2019.101903 + + 10.1016/j.msard.2019.101903 + 32980646 + + + + Goudriaan M, Jonkers I, van Dieen JH, Bruijn SM (2014) Arm swing in human walking: what is their drive? Gait Posture 40:321–326. https://doi.org/10.1016/j.gaitpost.2014.04.204 + + 10.1016/j.gaitpost.2014.04.204 + 24865637 + + + + Hill E, Stuart S, Lord S et al (2016) Vision, visuo-cognition and postural control in Parkinson’s disease: an associative pilot study. Gait Posture 48:74–76. https://doi.org/10.1016/j.gaitpost.2016.04.024 + + 10.1016/j.gaitpost.2016.04.024 + 27477712 + + + + Hollman JH, Childs KB, McNeil ML et al (2010) Number of strides required for reliable measurements of pace, rhythm and variability parameters of gait during normal and dual task walking in older individuals. Gait Posture 32:23–28. https://doi.org/10.1016/j.gaitpost.2010.02.017 + + 10.1016/j.gaitpost.2010.02.017 + 20363136 + + + + Huang X, Mahoney JM, Lewis MM et al (2012) Both coordination and symmetry of arm swing are reduced in Parkinson’s disease. Gait Posture. https://doi.org/10.1016/j.gaitpost.2011.10.180 + + 10.1016/j.gaitpost.2011.10.180 + 23177921 + + + + Killeen T, Elshehabi M, Filli L et al (2018) Arm swing asymmetry in overground walking. Sci Rep 8:1–10. https://doi.org/10.1038/s41598-018-31151-9 + + 10.1038/s41598-018-31151-9 + + + + Kuhtz-Buschbeck JP, Brockmann K, Gilster R et al (2008) Asymmetry of arm-swing not related to handedness. Gait Posture 27:447–454. https://doi.org/10.1016/j.gaitpost.2007.05.011 + + 10.1016/j.gaitpost.2007.05.011 + 17616462 + + + + Lewek MD, Poole R, Johnson J et al (2010) Arm swing magnitude and asymmetry during gait in the early stages of Parkinson’s disease. Gait Posture 31:256–260. https://doi.org/10.1016/j.gaitpost.2009.10.013 + + 10.1016/j.gaitpost.2009.10.013 + 19945285 + + + + Mainka S, Schroll A, Warmerdam E et al (2021) The power of musification: sensor-based music feedback improves arm swing in Parkinson’s disease. 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Mov Disord 31:1527–1534. https://doi.org/10.1002/mds.26720 + + 10.1002/mds.26720 + 27430880 + 5053872 + + + + Morris R, Stuart S, Mcbarron G et al (2019) Validity of mobility lab (version 2) for gait assessment in young adults, older adults and Parkinson’s disease. Physiol Meas 40:095003. https://doi.org/10.1088/1361-6579/ab4023 + + 10.1088/1361-6579/ab4023 + 31470423 + 8072263 + + + + Ospina BM, Chaparro JAV, Paredes JDA et al (2018) Objective arm swing analysis in early-stage Parkinson’s disease using an RGB-D Camera (Kinect ®). J Parkinsons Dis 8:563–570. https://doi.org/10.3233/JPD-181401 + + 10.3233/JPD-181401 + 30149466 + 6218143 + + + + Plate A, Sedunko D, Pelykh O et al (2015) Normative data for arm swing asymmetry: how (a)symmetrical are we? Gait Posture 41:13–18. https://doi.org/10.1016/j.gaitpost.2014.07.011 + + 10.1016/j.gaitpost.2014.07.011 + 25442669 + + + + Roggendorf J, Chen S, Baudrexel S et al (2012) Arm swing asymmetry in Parkinson’s disease measured with ultrasound based motion analysis during treadmill gait. Gait Posture 35:116–120. https://doi.org/10.1016/j.gaitpost.2011.08.020 + + 10.1016/j.gaitpost.2011.08.020 + 21962405 + + + + Schaafsma JD, Giladi N, Balash Y et al (2003) Gait dynamics in Parkinson’s disease: relationship to Parkinsonian features, falls and response to levodopa. J Neurol Sci 212:47–53. https://doi.org/10.1016/S0022-510X(03)00104-7 + + 10.1016/S0022-510X(03)00104-7 + 12809998 + + + + Stebbins GT, Goetz CG, Burn DJ et al (2013) How to identify tremor dominant and postural instability/gait difficulty groups with the movement disorder society unified Parkinson’s disease rating scale: comparison with the unified Parkinson’s disease rating scale. Mov Disord 28:668–670. https://doi.org/10.1002/mds.25383 + + 10.1002/mds.25383 + 23408503 + + + + Thaut MH, Rice RR, Braun Janzen T et al (2019) Rhythmic auditory stimulation for reduction of falls in Parkinson’s disease: a randomized controlled study. Clin Rehabil 33:34–43. https://doi.org/10.1177/0269215518788615 + + 10.1177/0269215518788615 + 30033755 + + + + Thompson E, Agada P, Wright WG et al (2017) Spatiotemporal gait changes with use of an arm swing cueing device in people with Parkinson’s disease. Gait Posture 58:46–51. https://doi.org/10.1016/j.gaitpost.2017.07.001 + + 10.1016/j.gaitpost.2017.07.001 + 28719842 + + + + Warmerdam E, Romijnders R, Welzel J et al (2020) Quantification of arm swing during walking in healthy adults and Parkinson’s disease patients: Wearable sensor-based algorithm development and validation. Sensors (switzerland) 20:1–12. https://doi.org/10.3390/s20205963 + + 10.3390/s20205963 + + + + Warmerdam E, Romijnders R, Hansen C et al (2021) Arm swing responsiveness to dopaminergic medication in Parkinson’s disease depends on task complexity. Npj Park Dis. https://doi.org/10.1038/s41531-021-00235-1 + + 10.1038/s41531-021-00235-1 + + + + Wood BH, Bilclough JA, Bowron A (2002) Incidence and prediction of falls in Parkinson’s disease: a prospective multidisciplinary study. J Neurol Neurosurg Psychiatry 72:721–725. https://doi.org/10.1136/jnnp.72.6.721 + + 10.1136/jnnp.72.6.721 + 12023412 + 1737913 + + + + Wu Y, Li Y, Liu AM et al (2016) Effect of active arm swing to local dynamic stability during walking. Hum Mov Sci 45:102–109. https://doi.org/10.1016/j.humov.2015.10.005 + + 10.1016/j.humov.2015.10.005 + 26615477 + + + + Zampier VC, Vitório R, Beretta VS et al (2018) Gait bradykinesia and hypometria decrease as arm swing frequency and amplitude increase. 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+ + + 36917343 + + 2023 + 03 + 14 + +
+ + 1432-2218 + + + 2023 + Mar + 14 + + + Surgical endoscopy + Surg Endosc + + Validation and effect of the NASA-TLX score on the assessment of the workload of pediatric robotic operations. + 10.1007/s00464-023-09959-y + + The objective of the study was to assess the validity of the NASA-TLX score in rating the workload of pediatric robotic operations. + The workload of 230 pediatric gastrointestinal and thoracic robotic operations was rated using the NASA-TLX score. The difference between the high workload group and the low workload group in each subscale of the NASA-TLX score was analyzed. The correlation of each subscale with the total workload score in the high workload group and low workload group was also analyzed. A logistic regression analysis was subsequently conducted to assess the effects of different factors (sex, age, weight, procedure duration, procedure specialties, combined malformation and blood loss) on the workload. + The average NASA-TLX score was 56.5 ± 5.1 for the total group, 56.9 ± 5.0 for the gastrointestinal group and 54.6 ± 4.8 for the thoracic group, p = 0.007. The score of the high workload group was 62.7 ± 3.2, while it was 50.6 ± 2.7 for the low workload group (p < 0.001). The score on each subscale was also significantly different between the high and low workload groups. In the high workload group, a stronger correlation was observed between the total score and TD and Fr and a lower correlation with MD and Pe. In the low workload group, all six subscales showed a moderate correlation with the total score. A multivariate logistic regression analysis revealed that the procedure duration was an independent influencing factor for a higher workload score. + NASA-TLX is a valid tool to rate the surgeon's workload in pediatric robotic surgery. A longer operative time contributes to a higher workload. + © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. + + + + Li + Shuai + S + + Department of Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, China. + + + + Liu + Yuan + Y + + Department of Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, China. + + + + Li + Kang + K + + Department of Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, China. + + + + Cao + Guoqing + G + + Department of Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, China. + + + + Li + Shiwang + S + + Department of Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, China. + + + + Mao + Yongzhong + Y + + Department of Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, China. + + + + Wang + Yong + Y + + Department of Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, China. + + + + Feng + Jianjun + J + + Department of Pediatric Surgery, The First Affiliated Hospital of Fujian Medical University, 20 Chazhong Road, Fuzhou, 350000, China. fengjj@fjmu.edu.cn. + + + + Tang + Shao-Tao + ST + + Department of Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, China. tshaotao83@126.com. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Surg Endosc + 8806653 + 0930-2794 + + IM + + NASA-TLX score + Pediatric + Robotic operation + Workload + +
+ + + + 2022 + 08 + 29 + + + 2023 + 02 + 12 + + + 2023 + 3 + 14 + 12 + 18 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917343 + 10.1007/s00464-023-09959-y + 10.1007/s00464-023-09959-y + + + + Meininger DD, Byhahn C, Heller K, Gutt CN, Westphal K (2001) Totally endoscopic nissen fundoplication with a robot system in a child. Surg Endosc 15:1359–1361 + + 10.1007/s00464-001-4200-3 + + + + Chang X, Cao G, Pu J, Li S, Zhang X, Tang ST (2021) Robot-assisted anorectal pull-through for anorectal malformations with rectourethral and rectovesical fistula: feasibility and short-term outcome. Surg Endosc 36:1910–1915 + + 10.1007/s00464-021-08473-3 + 33877410 + + + + Cundy TP, Shetty K, Clark J, Chang TP, Sriskandarajah K, Gattas NE, Najmaldin A, Yang GZ, Darzi A (2013) The first decade of robotic surgery in children. 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Adv Psychol 52:139–183 + + 10.1016/S0166-4115(08)62386-9 + + + + Tubbs-Cooley HL, Mara CA, Carle AC, Mark BA, Pickler RH (2019) Association of nurse workload with missed nursing care in the neonatal intensive care unit. JAMA Pediatr 173:44–51 + + 10.1001/jamapediatrics.2018.3619 + 30419138 + + + + Lund S, Yan M, D’Angelo J, Wang T, Hallbeck MS, Heller S, Zielinski M (2021) NASA-TLX assessment of workload in resident physicians and faculty surgeons covering trauma, surgical intensive care unit, and emergency general surgery services. Am J Surg 222:1158–1162 + + 10.1016/j.amjsurg.2021.10.020 + 34689977 + + + + Stefanidis D, Wang F, Korndorffer JR Jr, Dunne JB, Scott DJ (2010) Robotic assistance improves intracorporeal suturing performance and safety in the operating room while decreasing operator workload. 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+ + + 36917347 + + 2023 + 03 + 14 + +
+ + 1573-4994 + + + 2023 + Mar + 14 + + + Journal of fluorescence + J Fluoresc + + One-Pot Synthesis of Dual-Emissive Carbon Dots for Ratiometric Fluorescent Determination of Hg2. + 10.1007/s10895-023-03154-x + + Mercury ion is a global toxic and hazardous environmental pollutant. In this work, a facile and selective ratiometric fluorescent probe was constructed for the detection of mercury ion. The dual-emissive carbon dots (BYCDs) were fabricated by a one-pot hydrothermal method utilizing o-phenylenediamine and glycine as raw materials, and the prepared BYCDs had two independent fluorescence emission peaks at 426 nm and 543 nm under a single excitation wavelength. Based on the change of the intensity ratio of the two fluorescence emission peaks after the addition of Hg2+, a sensitive and selective ratiometric fluorescent probe based on BYCDs was constructed for the detection of Hg2+ with good linearity ranging from 0.95-50 μM and a detection limit of 0.27 μM. In addition, the recovery of this probe was satisfactory in the standard addition experiments of real water samples, and it could be applied to the analysis of Hg2+ in real water samples. + © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. + + + + Zheng + Yabin + Y + + State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, 15 3rd Ring North East Road, Chaoyang District, Beijing, 100029, China. + + + + Wan + Yudong + Y + + State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, 15 3rd Ring North East Road, Chaoyang District, Beijing, 100029, China. + + + + Wei + Yun + Y + + State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, 15 3rd Ring North East Road, Chaoyang District, Beijing, 100029, China. weiyun@mail.buct.edu.cn. + + + + Yu + Yingchun + Y + + State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, 15 3rd Ring North East Road, Chaoyang District, Beijing, 100029, China. yuyc@buct.edu.cn. + + + + eng + + + No. 22074004 + National Natural Science Foundation of China + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + Netherlands + J Fluoresc + 9201341 + 1053-0509 + + IM + + Dual-emissive carbon dots + Hg2+ detection + Ratiometric fluorescence + +
+ + + + 2022 + 12 + 17 + + + 2023 + 01 + 23 + + + 2023 + 3 + 14 + 12 + 18 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917347 + 10.1007/s10895-023-03154-x + 10.1007/s10895-023-03154-x + + + + Makam P, Shilpa R, Kandjani AE, Periasamy SR, Sabri YM, Madhu C, Bhargava SK, Govindaraju T (2018) SERS and fluorescence-based ultrasensitive detection of mercury in water. Biosens Bioelectron 100:556–564. https://doi.org/10.1016/j.bios.2017.09.051 + + 10.1016/j.bios.2017.09.051 + 29020666 + + + + Li L, Zhang J, Zhao W, Liu X, Luo L, Bi X, Cheng L, You T (2021) DNA-Modified electrochemiluminescent Tris(4,4’-Dicarboxylicacid-2,2’-Bipyridyl)Ruthenium(II) dichloride and assistant DNA-modified carbon nitride quantum dots for Hg2+ detection. 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+ + + 36917346 + + 2023 + 03 + 14 + +
+ + 1572-9699 + + + 2023 + Mar + 14 + + + Antonie van Leeuwenhoek + Antonie Van Leeuwenhoek + + Desulfovibrio mangrovi sp. nov., a sulfate-reducing bacterium isolated from mangrove sediments: a member of the proposed genus "Psychrodesulfovibrio". + 10.1007/s10482-023-01820-5 + + "Psychrodesulfovibrio", a proposed genus within the family Desulfovibrionaceae, is a group of sulfate-reducing bacteria with biogeochemical significance but restricted child taxa availability. In this study, a strictly anaerobic bacterium, designed strain FT415T, was isolated from mangrove sediments in Futian Mangrove Nature Reserve in Shenzhen, China. The strain was Gram-stain-negative, motile, and vibrio-shaped with a single polar flagellum, which grew at the temperature range of 15-42 °C (optimum 37 °C), pH range of 6.0-7.5 (optimum 6.8), and in the presence of 0-36 g l-1 NaCl (optimum 6 g l-1 NaCl). In the presence of sulfate, electron donors including lactate, ethanol, pyruvate, malate, fumarate, succinate, cysteine, and glycerol were incompletely oxidized to acetate, and H2 and formate were used as electron donors with acetate as the carbon source by strain FT415T. Sulfate, thiosulfate, sulfide, and anthraquinone-2,6-disulfonate were reduced in the presence of lactate. Fe(III) oxide was reduced without cell growth. Fermentative growth was observed with pyruvate and cysteine. Vitamins were not required for growth. The major cellular fatty acids (> 10%) were C16:0, summed feature 10 (C18:1 c11/t9/t6 and/or unknown ECL 17.834), C16:1 cis 9, and C18:0. The major polar lipids were phosphatidylethanolamine, phospholipids, and aminolipids. The predominant menaquinone was MK-6(H2). The genomic DNA G+C content was 56.7%. Phylogenetic analysis showed that strain FT415T shared a 98.1% similarity in 16S rRNA gene sequence, an average nucleotide identity value of 84.0%, an average amino-acid identity value of 85.4%, and a digital DNA-DNA hybridization value of 25.7% with its closest relative Desulfovibrio subterraneus HN2T, which has been proposed to be transferred to the genus "Psychrodesulfovibrio". Based on phenotypic, phylogenetic, and genotypic evidence, a new species of the family Desulfovibrionaceae, Desulfovibrio mangrovi sp. nov. was proposed with the type strain FT415T (=GDMCC 1.3410T=KCTC 25525T). + © 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG. + + + + Zhou + Jinjie + J + + Archaeal Biology Center, Institute for Advanced Study, Shenzhen University, Shenzhen, Guangdong, China. + + + Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, China. + + + Shenzhen Key Laboratory of Marine Microbiome Engineering, Institute for Advanced Study, Shenzhen University, Shenzhen, Guangdong, China. + + + + Zhang + Cui-Jing + CJ + + Archaeal Biology Center, Institute for Advanced Study, Shenzhen University, Shenzhen, Guangdong, China. + + + Shenzhen Key Laboratory of Marine Microbiome Engineering, Institute for Advanced Study, Shenzhen University, Shenzhen, Guangdong, China. + + + + Li + Meng + M + + Archaeal Biology Center, Institute for Advanced Study, Shenzhen University, Shenzhen, Guangdong, China. limeng848@szu.edu.cn. + + + Shenzhen Key Laboratory of Marine Microbiome Engineering, Institute for Advanced Study, Shenzhen University, Shenzhen, Guangdong, China. limeng848@szu.edu.cn. + + + + eng + + + 42207144 + National Natural Science Foundation of China + + + + 32225003 + National Natural Science Foundation of China + + + + 2021TQ0212 + China Postdoctoral Science Foundation + + + + 2019FY100700 + National Science and Technology Fundamental Resources Investigation Program of China + + + + 2020KCXTD023 + Innovation Team Project of Universities in Guangdong Province + + + + JCYJ20200109105010363 + Shenzhen Science and Technology Program + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + Netherlands + Antonie Van Leeuwenhoek + 0372625 + 0003-6072 + + IM + + Desulfovibrio + Mangrove sediments + New species + Psychrodesulfovibrio + Sulfate-reducing bacteria + +
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+ + + 36917349 + + 2023 + 03 + 14 + +
+ + 1433-7339 + + 31 + 4 + + 2023 + Mar + 14 + + + Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer + Support Care Cancer + + High-quality phase 3 studies do not support the use of somatostatin analogues to reduce vomiting in malignant bowel obstruction. + + 211 + + 10.1007/s00520-023-07669-8 + + + Boland + Jason W + JW + http://orcid.org/0000-0001-5272-3057 + + Wolfson Palliative Care Research Centre, Hull York Medical School, University of Hull, Hull, UK. Jason.Boland@hyms.ac.uk. + + + Care Plus Group, North East Lincolnshire, UK. Jason.Boland@hyms.ac.uk. + + + + Boland + Elaine G + EG + http://orcid.org/0000-0003-2571-5929 + + Hull University Teaching Hospitals NHS Trust, Cottingham, UK. + + + + Currow + David C + DC + http://orcid.org/0000-0003-1988-1250 + + Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, Australia. + + + + eng + + Letter + Comment + + + 2023 + 03 + 14 + +
+ + Germany + Support Care Cancer + 9302957 + 0941-4355 + + IM + + + Support Care Cancer. 2022 Jun;30(6):4711-4728 + 35274188 + + +
+ + + + 2022 + 08 + 03 + + + 2023 + 03 + 04 + + + 2023 + 3 + 14 + 12 + 18 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917349 + 10.1007/s00520-023-07669-8 + 10.1007/s00520-023-07669-8 + + + + Madariaga A, Lau J, Ghoshal A, Dzierzanowski T, Larkin P, Sobocki J et al (2022) MASCC multidisciplinary evidence-based recommendations for the management of malignant bowel obstruction in advanced cancer. Support Care Cancer 30(6):4711–4728. https://doi.org/10.1007/s00520-022-06889-8 + + 10.1007/s00520-022-06889-8 + 35274188 + 9046338 + + + + Obita GP, Boland EG, Currow DC, Johnson MJ, Boland JW (2016) Somatostatin analogues compared with placebo and other pharmacologic agents in the management of symptoms of inoperable malignant bowel obstruction: a systematic review. J Pain Symptom Manag 52(6):901–19 e1. https://doi.org/10.1016/j.jpainsymman.2016.05.032 + + 10.1016/j.jpainsymman.2016.05.032 + 27697568 + + + + Boland JW, Koffman J, Boland EG (2022) What do we do with all the evidence for symptoms in palliative care? Palliat Med 36(6):892–894. https://doi.org/10.1177/02692163221098005 + + 10.1177/02692163221098005 + 35658645 + + + + Baddeley E, Bravington A, Johnson M, Currow DC, Murtagh FE, Boland E et al (2020) Development of a core outcome set to use in the research and assessment of malignant bowel obstruction: protocol for the RAMBO study. BMJ Open 10(6):e039154. https://doi.org/10.1136/bmjopen-2020-039154 + + 10.1136/bmjopen-2020-039154 + 32595168 + 7322279 + + + + Baddeley E, Mann M, Bravington A, Johnson MJ, Currow D, Murtagh FEM et al (2022) Symptom burden and lived experiences of patients, caregivers and healthcare professionals on the management of malignant bowel obstruction: a qualitative systematic review. Palliat Med 36(6):895–911. https://doi.org/10.1177/02692163221081331 + + 10.1177/02692163221081331 + 35260004 + 9174615 + + + + Bravington A, Obita G, Baddeley E, Johnson MJ, Murtagh FEM, Currow D et al (2022) The range and suitability of outcome measures used in the assessment of palliative treatment for inoperable malignant bowel obstruction: a systematic review. Palliat Med 36(9):1336–1350 + + 10.1177/02692163221122352 + 36131489 + + + + Star A, Boland JW (2018) Updates in palliative care - recent advancements in the pharmacological management of symptoms. Clin Med (Lond) 18(1):11–16. https://doi.org/10.7861/clinmedicine.18-1-11 + + 10.7861/clinmedicine.18-1-11 + 29436433 + + + + Boland JW, Boland EG (2021) Malignant bowel obstruction. In: Cherny N, Fallon MT, Kaasa S et al (eds) Oxford textbook of palliative medicine, 6th edn. Oxford University Press, pp 904–17 + + + +
+ + + 36917348 + + 2023 + 03 + 14 + +
+ + 1437-2320 + + 46 + 1 + + 2023 + Mar + 14 + + + Neurosurgical review + Neurosurg Rev + + Cerebral revascularization for complex middle cerebral artery aneurysms: surgical strategies and outcomes in a single center. + + 68 + + 10.1007/s10143-023-01977-7 + + Cerebral revascularization is the ultimate treatment for a subset of complex middle cerebral artery (MCA) aneurysms. The decision for the revascularization strategy should be made during the treatment process. This study aimed to summarize the revascularization strategies for different types of complex MCA aneurysms and their outcomes. The clinical data of patients with complex MCA aneurysms who underwent cerebral revascularization since 2015 were analyzed retrospectively. The aneurysms were classified according to the location and other main characteristics that affect the selection of surgical modalities. The corresponding surgical modalities and treatment outcomes were summarized. A total of 29 patients with 29 complex MCA aneurysms were treated with cerebral revascularization from 2015 to 2022. Treated aneurysms were located at the prebifurcation segment in 7 patients, bifurcation segment in 12 patients, and postbifurcation segment in 10 patients. Surgical modalities in the prebifurcation segment included four high-flow extracranial-to-intracranial (EC-IC) bypasses with aneurysm trapping or proximal occlusion, two IC-IC bypasses with aneurysm excision, and one combination bypass with aneurysm excision. In the bifurcation segment, surgical modalities included two low-flow EC-IC bypasses with aneurysm excision or trapping, six IC-IC bypasses with aneurysm excision, three combination bypasses with aneurysm excision, and one constructive clipping with IC-IC bypass. In the postbifurcation segment, surgical modalities included nine IC-IC bypasses with aneurysm excision and low-flow EC-IC bypass with aneurysm trapping. The revascularization strategy for prebifurcation aneurysms was determined based on the involvement of lenticulostriate arteries, whereas the strategy for bifurcation aneurysms was determined based on the number of distal bifurcations and the shape of the aneurysm. The location of the aneurysm determined the revascularization strategy for aneurysms in the postbifurcation segments. Angiography demonstrated that aneurysms were completely obliterated in 26 cases and shrank in 3 cases, and all bypasses except one were patent. The mean follow-up period was 47.5 months. Three patients developed hemiplegic paralysis, and one developed transient aphasia postoperatively due to cerebral ischemia. No new neurological dysfunction occurred in the other 25 patients with no recurrence or enlargement of aneurysms during the follow-up. Prebifurcation aneurysms involving the lenticulostriate arteries require proximal occlusion with high-flow bypass. Most of the other aneurysms can be safely excised or trapped by appropriate revascularization strategies according to their location and orientation. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Wang + Xingdong + X + + Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin, China. + + + + Han + Guoqing + G + + Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin, China. + + + + Wang + Hu + H + + Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin, China. + + + Department of Neurosurgery, Tianjin Central Hospital for Neurosurgery and Neurology, Tianjin, China. + + + + Shang + Yanguo + Y + + Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin, China. + + + Department of Neurosurgery, Tianjin Central Hospital for Neurosurgery and Neurology, Tianjin, China. + + + + Shi + Minggang + M + + Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin, China. + + + Department of Neurosurgery, Tianjin Central Hospital for Neurosurgery and Neurology, Tianjin, China. + + + + Wang + Xuan + X + + Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin, China. + + + Department of Neurosurgery, Tianjin Central Hospital for Neurosurgery and Neurology, Tianjin, China. + + + + Bao + Jingang + J + + Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin, China. + + + + Wang + Zhiqiang + Z + + Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin, China. + + + + Tong + Xiaoguang + X + + Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin, China. tongxiaoguanghhh@163.com. + + + Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin, China. tongxiaoguanghhh@163.com. + + + Department of Neurosurgery, Tianjin Central Hospital for Neurosurgery and Neurology, Tianjin, China. tongxiaoguanghhh@163.com. + + + Laboratory of Microneurosurgery, Tianjin Neurosurgical Institute, Tianjin, China. tongxiaoguanghhh@163.com. + + + Tianjin Key Laboratory of Cerebral Vascular and Neural Degenerative Diseases, Tianjin, China. tongxiaoguanghhh@163.com. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Neurosurg Rev + 7908181 + 0344-5607 + + IM + + Cerebral revascularization + Complex aneurysm + High-flow bypass + Intracranial–intracranial bypass + Middle cerebral artery + +
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+ + + 36917353 + + 2023 + 03 + 14 + +
+ + 1432-0738 + + + 2023 + Mar + 14 + + + Archives of toxicology + Arch Toxicol + + In memoriam Thomas Gebel. + 10.1007/s00204-023-03473-9 + + + Hengstler + Jan G + JG + + IfADo Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund, Mainz, Germany. hengstler@ifado.de. + + + + Bolt + Hermann + H + + IfADo Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund, Mainz, Germany. + + + + Heinrich + Uwe + U + + IfADo Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund, Mainz, Germany. + + + + Hartwig + Andrea + A + + IfADo Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund, Mainz, Germany. + + + + Landsiedel + Robert + R + + IfADo Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund, Mainz, Germany. + + + + eng + + Editorial + + + 2023 + 03 + 14 + +
+ + Germany + Arch Toxicol + 0417615 + 0340-5761 + + IM +
+ + + + 2023 + 02 + 21 + + + 2023 + 02 + 21 + + + 2023 + 3 + 14 + 12 + 19 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917353 + 10.1007/s00204-023-03473-9 + 10.1007/s00204-023-03473-9 + + +
+ + + 36917354 + + 2023 + 03 + 14 + +
+ + 1943-393X + + + 2023 + Mar + 14 + + + Attention, perception & psychophysics + Atten Percept Psychophys + + Contralateral delay activity, but not alpha lateralization, indexes prioritization of information for working memory storage. + 10.3758/s13414-023-02681-w + + Working memory is inherently limited, which makes it important to select and maintain only task-relevant information and to protect it from distraction. Previous research has suggested the contralateral delay activity (CDA) and lateralized alpha oscillations as neural candidates for such a prioritization process. While most of this work focused on distraction during encoding, we examined the effect of external distraction presented during memory maintenance. Participants memorized the orientations of three lateralized objects. After an initial distraction-free maintenance interval, distractors appeared in the same location as the targets or in the opposite hemifield. This distraction was followed by another distraction-free interval. Our results show that CDA amplitudes were stronger in the interval before compared with the interval after the distraction (i.e., CDA amplitudes were stronger in response to targets compared with distractors). This amplitude reduction in response to distractors was more pronounced in participants with higher memory accuracy, indicating prioritization and maintenance of relevant over irrelevant information. In contrast, alpha lateralization did not change from the interval before distraction compared with the interval after distraction, and we found no correlation between alpha lateralization and memory accuracy. These results suggest that alpha lateralization plays no direct role in either selective maintenance of task-relevant information or inhibition of distractors. Instead, alpha lateralization reflects the current allocation of spatial attention to the most salient information regardless of task-relevance. In contrast, CDA indicates flexible allocation of working memory resources depending on task-relevance. + © 2023. The Author(s). + + + + Schroeder + Svea C Y + SCY + http://orcid.org/0000-0002-1117-2823 + + University of Münster, Münster, Germany. schroeder.svea@gmail.com. + + + Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience, Münster, Germany. schroeder.svea@gmail.com. + + + + Aagten-Murphy + David + D + + University of Cambridge, Cambridge, UK. + + + + Busch + Niko A + NA + + University of Münster, Münster, Germany. + + + Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience, Münster, Germany. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Atten Percept Psychophys + 101495384 + 1943-3921 + + IM + + Alpha oscillations + Attention + Contralateral delay activity + Distractor inhibition + Visual working memory + +
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+ + + 36917351 + + 2023 + 03 + 14 + +
+ + 1880-4233 + + + 2023 + Mar + 14 + + + Breast cancer (Tokyo, Japan) + Breast Cancer + + The effect of combined risk factors on breast cancer-related lymphedema: a study using decision trees. + 10.1007/s12282-023-01450-9 + + The effect of combined risk factors on breast cancer-related lymphedema (BCRL) development has not yet been investigated. This study aimed to determine the combination of risk factors associated with BCRL development in patients who underwent breast cancer resection, including axillary lymph node dissection (ALND). + The participants included 129 women who were diagnosed with early-stage breast cancer and underwent breast cancer resection in this retrospective observational study. We performed a decision tree analysis to detect the combination of risk factors associated with BCRL development using age, body mass index (BMI), surgical side, mastectomy, the extent of ALND, and adjuvant therapy (chemotherapy, hormone therapy, and radiation therapy). + Of the 129 participants, 11 (8.5%) developed BCRL. Postoperative chemotherapy was the optimal variable selected to classify patients who developed BCRL and those who did not. In participants with postoperative chemotherapy, the extent of ALND was selected as the second layer of the decision tree. When ALND was at level 3, BMI was selected as the third layer. We found that BCRL incidence was 44.4% in individuals with a BMI of 23.0 or higher. + The combination of postoperative chemotherapy, level 3 ALND, and BMI of 23.0 or higher may further increase the risk of developing BCRL. The decision tree model will enable the identification of patients with a high risk of developing BCRL, and thus, preventive intervention, careful monitoring, and early treatment will be possible. + © 2023. The Author(s), under exclusive licence to The Japanese Breast Cancer Society. + + + + Jinbo + Kazumi + K + + Department of Rehabilitation, Kita-Fukushima Medical Center, Date, Japan. + + + + Fujita + Takaaki + T + http://orcid.org/0000-0002-9009-8325 + + Department of Occupational Therapy, School of Health Sciences, Fukushima Medical University, 10-6 Sakaemachi, Fukushima City, Fukushima, Japan. t-fujita@fmu.ac.jp. + + + + Kasahara + Ryuichi + R + + Department of Rehabilitation, Kita-Fukushima Medical Center, Date, Japan. + + + + Jinbo + Ryohei + R + + Department of Rehabilitation, Kita-Fukushima Medical Center, Date, Japan. + + + + Kisara + Sayaka + S + + Department of Rehabilitation, Kita-Fukushima Medical Center, Date, Japan. + + + + Onobe + Jun + J + + Department of Rehabilitation, Faculty of Medical Science & Welfare, Tohoku Bunka Gakuen University, Sendai, Japan. + + + + Kimijima + Izo + I + + Kimijima Breast Clinic, Fukushima, Japan. + + + + Yasuda + Mitsuhiko + M + + Breast Center, Kita-Fukushima Medical Center, Date, Japan. + + + + Yamamoto + Yuichi + Y + + Department of Rehabilitation, Kita-Fukushima Medical Center, Date, Japan. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Japan + Breast Cancer + 100888201 + 1340-6868 + + IM + + BMI + Breast cancer + Lymphedema + Risk factor + +
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Int J Radiat Oncol Biol Phys. 1986;12:2079–83. + + 10.1016/0360-3016(86)90005-2 + 3793544 + + + + Swaroop MN, Ferguson CM, Horick NK, Skolny MN, Miller CL, Jammallo LS, et al. Impact of adjuvant taxane-based chemotherapy on development of breast cancer-related lymphedema: Results from a large prospective cohort. Breast Cancer Res Treat. 2015;151:393–403. + + 10.1007/s10549-015-3408-1 + 25940996 + 4432026 + + + + Manirakiza A, Irakoze L, Shui L, Manirakiza S, Ngendahayo L. Lymphoedema after breast cancer treatment is associated with higher body mass index: a systematic review and meta-analysis. East Afr Health Res J. 2019;3:178–92. + + 10.24248/eahrj.v3i2.605 + 34308212 + 8279288 + + + + Kim M, Kim SW, Lee SU, Lee NK, Jung SY, Kim TH, Lee ES, Kang HS, Shin KH. A model to estimate the risk of breast cancer-related lymphedema: combinations of treatment-related factors of the number of dissected axillary nodes, adjuvant chemotherapy, and radiation therapy. 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+ + + 36917359 + + 2023 + 03 + 14 + +
+ + 0942-0940 + + + 2023 + Mar + 14 + + + Acta neurochirurgica + Acta Neurochir (Wien) + + Endoscopic transoral resection for an upper cervical chordoma in a pediatric patient. + 10.1007/s00701-023-05548-z + + Upper cervical chordoma (UCC) is a rare disease, and although transoral approaches are the methods of choice, minimally invasive techniques have not been established. + We report the successful use of endoscopic transoral surgery for upper cervical chordoma at the C1-3 levels in the midline epidural space in an 8-year-old girl who presented with neck pain and quadriplegia. Three months after occipitocervical posterior fixation, endoscopic transoral surgery was performed and the tumor was nearly totally removed. + Endoscopic transoral surgery in pediatric patients with UCCs is a minimally invasive and safe technique. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature. + + + + Morinaga + Yusuke + Y + + Department of Neurosurgery, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi, 321-0293, Japan. + + + + Tsunemi + Yasuhiro + Y + + Department of Otorhinolaryngology, Head and Neck Surgery, Dokkyo Medical University School of Medicine, Tochigi, Japan. + + + + Kurokawa + Ryu + R + + Department of Neurosurgery, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi, 321-0293, Japan. + + + + Akutsu + Hiroyoshi + H + http://orcid.org/0000-0001-9253-1869 + + Department of Neurosurgery, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi, 321-0293, Japan. h-akutsu887@dokkyomed.ac.jp. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Austria + Acta Neurochir (Wien) + 0151000 + 0001-6268 + + IM + + Endoscopic transoral surgery + Pediatric patient + Tumor + Upper cervical chordoma + +
+ + + + 2023 + 02 + 07 + + + 2023 + 02 + 25 + + + 2023 + 3 + 14 + 12 + 19 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917359 + 10.1007/s00701-023-05548-z + 10.1007/s00701-023-05548-z + + + + Aldana PR, Naseri I, La Corte E (2012) The nasoaxial line: a new method of accurately predicting the inferior limit of the endoscopic endonasal approach to the craniovertebral junction. Neurosurgery 71(2 Suppl Operative):ons308–ons314. https://doi.org/10.1227/NEU.0b013e318266e488 + + 10.1227/NEU.0b013e318266e488 + 22791031 + + + + Delgado TE, Garrido E, Harwick RD (1981) Labiomandibular, transoral approach to chordomas in the clivus and upper cervical spine. Neurosurgery 8(6):675–679. https://doi.org/10.1227/00006123-198106000-00007 + + 10.1227/00006123-198106000-00007 + 7279154 + + + + Kim P, Murata H, Kurokawa R, Takaishi Y, Asakuno K, Kawamoto T (2007) Myoarchitectonic spinolaminoplasty: efficacy in reconstituting the cervical musculature and preserving biomechanical function. J Neurosurg Spine 7(3):293–304. https://doi.org/10.3171/SPI-07/09/293 + + 10.3171/SPI-07/09/293 + 17877263 + + + + Shidoh S, Toda M, Kawase T, Nakajima H, Tomita T, Ogawa K, Yoshida K (2014) Transoral vs. endoscopic endonasal approach for clival/upper cervical chordoma. Neurol Med Chir (Tokyo) 54(12):991–998. https://doi.org/10.2176/nmc.st.2014-0135 + + 10.2176/nmc.st.2014-0135 + 25446380 + + + + Taran S, Yusof AH, Yusof MI (2015) Endoscopic transoral resection of an axial chordoma: a case report. Malays Orthop J 9(3):75–77. https://doi.org/10.5704/MOJ.1511.015 + + 10.5704/MOJ.1511.015 + 28611918 + 5393143 + + + + +
+ + + 36917361 + + 2023 + 03 + 14 + +
+ + 0942-0940 + + + 2023 + Mar + 14 + + + Acta neurochirurgica + Acta Neurochir (Wien) + + Antithrombotic agent usage before ictus in aneurysmal subarachnoid hemorrhage: relation to hemorrhage severity, clinical course, and outcome. + 10.1007/s00701-023-05556-z + + The number of patients with aneurysmal subarachnoid hemorrhage (aSAH) who are on antithrombotic agents before ictus is rising. However, their effect on early brain injury and disease development remains unclear. The primary aim of this study was to determine if antithrombotic agents (antiplatelets and anticoagulants) were associated with a worse initial hemorrhage severity, rebleeding rate, clinical course, and functional recovery after aSAH. + In this observational study, those 888 patients with aSAH, treated at the neurosurgical department, Uppsala University Hospital, between 2008 and 2018 were included. Demographic, clinical, radiological (Fisher and Hijdra score), and outcome (Extended Glasgow Outcome Scale one year post-ictus) variables were assessed. + Out of 888 aSAH patients, 14% were treated with antithrombotic agents before ictus. Seventy-five percent of these were on single therapy of antiplatelets, 23% on single therapy of anticoagulants, and 3% on a combination of antithrombotic agents. Those with antithrombotic agents pre-ictus were significantly older and exhibited more co-morbidities and a worse coagulation status according to lab tests. Antithrombotic agents, both as one group and as subtypes (antiplatelets and anticoagulants), were not associated with hemorrhage severity (Hijdra score/Fisher) nor rebleeding rate. The clinical course did not differ in terms of delayed ischemic neurological deficits or last-tier treatment with thiopental and decompressive craniectomy. These patients experienced a higher mortality and lower rate of favorable outcome in univariate analyses, but this did not hold true in multiple logistic regression analyses after adjustment for age and co-morbidities. + After adjustment for age and co-morbidities, antithrombotic agents before aSAH ictus were not associated with worse hemorrhage severity, rebleeding rate, clinical course, or long-term functional recovery. + © 2023. The Author(s). + + + + Kultanen + Hanna + H + + Department of Medical Sciences, Section of Neurosurgery, Uppsala University, SE-751 85, Uppsala, Sweden. + + + + Lewén + Anders + A + + Department of Medical Sciences, Section of Neurosurgery, Uppsala University, SE-751 85, Uppsala, Sweden. + + + + Ronne-Engström + Elisabeth + E + + Department of Medical Sciences, Section of Neurosurgery, Uppsala University, SE-751 85, Uppsala, Sweden. + + + + Enblad + Per + P + + Department of Medical Sciences, Section of Neurosurgery, Uppsala University, SE-751 85, Uppsala, Sweden. + + + + Svedung Wettervik + Teodor + T + http://orcid.org/0000-0002-4556-5721 + + Department of Medical Sciences, Section of Neurosurgery, Uppsala University, SE-751 85, Uppsala, Sweden. teodor.svedung-wettervik@neuro.uu.se. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Austria + Acta Neurochir (Wien) + 0151000 + 0001-6268 + + IM + + Aneurysmal subarachnoid hemorrhage + Anticoagulant + Antiplatelet + Clinical outcome + Hijdra score + Neurointensive care + +
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+ + + 36917358 + + 2023 + 03 + 14 + +
+ + 1573-7403 + + + 2023 + Mar + 14 + + + Pituitary + Pituitary + + Refractory corticotroph adenomas. + 10.1007/s11102-023-01308-5 + + The majority of corticotroph adenomas are benign but some are locally invasive, demonstrate high rates of recurrence, and exhibit a relatively poor response to often repeated surgical, medical, and radiation treatment. Herein, we summarize the currently known somatic and genetic mutations and other molecular factors that influence the pathogenesis of these tumors and discuss currently available therapies. Although recent molecular studies have advanced our understanding of the pathogenesis and behavior of these refractory corticotroph adenomas, these insights do not reliably guide treatment choices at present. Development of additional diagnostic tools and novel tumor-directed therapies that offer efficacious treatment choices for patients with refractory corticotroph adenomas are needed. + © 2023. The Author(s). + + + + Sumal + Amit K S + AKS + + Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA. + + + + Zhang + Dongyun + D + + Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA. + + + + Heaney + Anthony P + AP + + Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA. aheaney@mednet.ucla.edu. + + + Department of Neurosurgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA. aheaney@mednet.ucla.edu. + + + + eng + + Journal Article + Review + + + 2023 + 03 + 14 + +
+ + United States + Pituitary + 9814578 + 1386-341X + + IM + + Refractory corticotroph adenomas + +
+ + + + 2023 + 03 + 04 + + + 2023 + 3 + 14 + 12 + 19 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917358 + 10.1007/s11102-023-01308-5 + 10.1007/s11102-023-01308-5 + + + + Lasolle H, Vasiljevic A, Jouanneau E, Ilie MD, Raverot G (2022) Aggressive corticotroph tumors and carcinomas. J Neuroendocrinol 34(8):e13169. https://doi.org/10.1111/jne.13169 + + 10.1111/jne.13169 + 35979732 + 9542524 + + + + Yamamoto M, Nakao T, Ogawa W, Fukuoka H (2021) Aggressive Cushing’s Disease: Molecular Pathology and its therapeutic Approach. Front Endocrinol (Lausanne) 12:650791 Published 2021 Jun 16. https://doi.org/10.3389/fendo.2021.650791 + + 10.3389/fendo.2021.650791 + 34220707 + + + + Theodoropoulou M, Reincke M (2022) Genetics of Cushing’s disease: from the lab to clinical practice. 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+ + + 36917356 + + 2023 + 03 + 14 + +
+ + 2211-3436 + + + 2023 + Mar + 14 + + + Cellular oncology (Dordrecht) + Cell Oncol (Dordr) + + STIM1-regulated exosomal EBV-LMP1 empowers endothelial cells with an aggressive phenotype by activating the Akt/ERK pathway in nasopharyngeal carcinoma. + 10.1007/s13402-023-00790-0 + + Stromal interaction molecule 1 (STIM1)-mediated Ca2+ signaling regulates tumor angiogenesis in nasopharyngeal carcinoma (NPC), an Epstein-Barr virus (EBV)-related human malignancy. However, the mechanism by which STIM1 modulates endothelial functional phenotypes contributing to tumor angiogenesis remains elusive. + NPC cell-derived exosomes were isolated via differential centrifugation and observed using transmission electron microscopy. Exosome particle sizes were assessed by nanoparticle tracking analysis (NTA). Uptake of exosomes by recipient ECs was detected by fluorescent labeling of the exosomes with PKH26. Tumor angiogenesis-associated profiles were characterized by determining cell proliferation, migration, tubulogenesis and permeability in human umbilical vein endothelial cells (HUVECs). Activation of the Akt/ERK pathway was assessed by detecting the phosphorylation levels using Western blotting. A chick embryo chorioallantoic membrane (CAM) xenograft model was employed to study tumor-associated neovascularization in vivo. + We found that NPC cell-derived exosomes harboring EBV-encoded latent membrane protein 1 (LMP1) promoted proliferation, migration, tubulogenesis and permeability by activating the Akt/ERK pathway in ECs. STIM1 silencing reduced LMP1 enrichment in NPC cell-derived exosomes, thereby reversing its pro-oncogenic effects in an Akt/ERK pathway-dependent manner. Furthermore, STIM1 knockdown in NPC cells blunted tumor-induced vascular network formation and inhibited intra-tumor neovascularization in the chorioallantoic membrane (CAM) xenograft model. + STIM1 regulates tumor angiogenesis by controlling exosomal EBV-LMP1 delivery to ECs in the NPC tumor microenvironment. Blocking exosome-mediated cell-to-cell horizontal transfer of EBV-associated oncogenic signaling molecules may be an effective therapeutic strategy for NPC. + © 2023. Springer Nature Switzerland AG. + + + + Deng + Yayan + Y + + Department of Medical Oncology, Guangxi Medical University Cancer Hospital, 71 Hedi Road, Nanning, 530021, China. + + + + Liu + Xue + X + + Department of Medical Oncology, Guangxi Medical University Cancer Hospital, 71 Hedi Road, Nanning, 530021, China. + + + + Huang + Yujuan + Y + + Department of Medical Oncology, Guangxi Medical University Cancer Hospital, 71 Hedi Road, Nanning, 530021, China. + + + + Ye + Jiaxiang + J + + Department of Medical Oncology, Guangxi Medical University Cancer Hospital, 71 Hedi Road, Nanning, 530021, China. + + + + He + Qian + Q + + Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Shenzhen, 518055, China. + + + + Luo + Yue + Y + + Department of Medical Oncology, Guangxi Medical University Cancer Hospital, 71 Hedi Road, Nanning, 530021, China. + + + + Chen + Yong + Y + + Department of Medical Oncology, Guangxi Medical University Cancer Hospital, 71 Hedi Road, Nanning, 530021, China. + + + + Li + Qiuyun + Q + + Department of Medical Oncology, Guangxi Medical University Cancer Hospital, 71 Hedi Road, Nanning, 530021, China. + + + + Lin + Yan + Y + + Department of Medical Oncology, Guangxi Medical University Cancer Hospital, 71 Hedi Road, Nanning, 530021, China. + + + + Liang + Rong + R + + Department of Medical Oncology, Guangxi Medical University Cancer Hospital, 71 Hedi Road, Nanning, 530021, China. + + + + Li + Yongqiang + Y + + Department of Medical Oncology, Guangxi Medical University Cancer Hospital, 71 Hedi Road, Nanning, 530021, China. + + + + Wei + Jiazhang + J + http://orcid.org/0000-0001-8611-3118 + + Department of Otolaryngology & Head and Neck, The People's Hospital of Guangxi Zhuang Autonomous Region, 6 Taoyuan Road, Nanning, 530021, China. somnent@gmail.com. + + + Institute of Oncology, Guangxi Academy of Medical Sciences, 6 Taoyuan Road, Nanning, 530021, China. somnent@gmail.com. + + + + Zhang + Jinyan + J + http://orcid.org/0000-0002-9874-2744 + + Department of Medical Oncology, Guangxi Medical University Cancer Hospital, 71 Hedi Road, Nanning, 530021, China. zhangjinyan@gxmu.edu.cn. + + + + eng + + + 2020GXNSFBA297059 + Natural Science Foundation of Guangxi Province + + + + 2020GXNSFBA297024 + Natural Science Foundation of Guangxi Province + + + + 82073004 + National Natural Science Foundation of China + + + + 82002859 + National Natural Science Foundation of China + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + Netherlands + Cell Oncol (Dordr) + 101552938 + 2211-3428 + + IM + + Angiogenesis + Latent membrane protein 1 + Nasopharyngeal carcinoma + Stromal interaction molecule 1 + Tumor-derived exosomes + +
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+ + 1432-1203 + + + 2023 + Mar + 14 + + + Human genetics + Hum Genet + + Genome-wide analysis of genetic pleiotropy and causal genes across three age-related ocular disorders. + 10.1007/s00439-023-02542-4 + + Age-related macular degeneration (AMD), cataract, and glaucoma are leading causes of blindness worldwide. Previous genome-wide association studies (GWASs) have revealed a variety of susceptible loci associated with age-related ocular disorders, yet the genetic pleiotropy and causal genes across these diseases remain poorly understood. By leveraging large-scale genetic and observational data from ocular disease GWASs and UK Biobank (UKBB), we found significant pairwise genetic correlations and consistent epidemiological associations among these ocular disorders. Cross-disease meta-analysis uncovered seven pleiotropic loci, three of which were replicated in an additional cohort. Integration of variants in pleiotropic loci and multiple single-cell omics data identified that Müller cells and astrocytes were likely trait-related cell types underlying ocular comorbidity. In addition, we comprehensively integrated eye-specific gene expression quantitative loci (eQTLs), epigenomic profiling, and 3D genome data to prioritize causal pleiotropic genes. We found that pleiotropic genes were essential in nerve development and eye pigmentation, and targetable by aflibercept and pilocarpine for the treatment of AMD and glaucoma. These findings will not only facilitate the mechanistic research of ocular comorbidities but also benefit the therapeutic optimization of age-related ocular diseases. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Yao + Xueming + X + + Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin, 300052, China. + + + + Yang + Hongxi + H + + Department of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China. + + + + Han + Han + H + + Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin, 300052, China. + + + + Kou + Xuejing + X + + Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin, 300052, China. + + + + Jiang + Yuhan + Y + + Department of Bioinformatics, The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China. + + + + Luo + Menghan + M + + Department of Bioinformatics, The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China. + + + + Zhou + Yao + Y + + Department of Bioinformatics, The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China. + + + + Wang + Jianhua + J + + Department of Bioinformatics, The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China. + + + + Fan + Xutong + X + + Department of Bioinformatics, The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China. + + + + Wang + Xiaohong + X + + Department of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China. xiaohongwang@tmu.edu.cn. + + + + Li + Mulin Jun + MJ + http://orcid.org/0000-0003-3598-3679 + + Department of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China. mulin@tmu.edu.cn. + + + Department of Bioinformatics, The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China. mulin@tmu.edu.cn. + + + + Yan + Hua + H + + Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin, 300052, China. zyyyanhua@tmu.edu.cn. + + + Laboratory of Molecular Ophthalmology, Tianjin Medical University, Tianjin, 300070, China. zyyyanhua@tmu.edu.cn. + + + School of Medicine, Nankai University, Tianjin, 300071, China. zyyyanhua@tmu.edu.cn. + + + + eng + + + 82020108007 + National Natural Science Foundation of China + + + + 32070675 + National Natural Science Foundation of China + + + + 81830026 + National Natural Science Foundation of China + + + + 2021YFC2401404 + National Key Research and Development Program of China + + + + + Journal Article + + + 2023 + 03 + 14 + +
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+ + + 36917360 + + 2023 + 03 + 14 + +
+ + 0942-0940 + + + 2023 + Mar + 14 + + + Acta neurochirurgica + Acta Neurochir (Wien) + + Cavitation with low-energy sonication during focused ultrasound thalamotomy for a patient with tremor-dominant Parkinson's disease: a potential risk. + 10.1007/s00701-023-05551-4 + + We report a patient with tremor-dominant Parkinson's disease who had a mild cavitation bioeffect during magnetic resonance-guided focused ultrasound thalamotomy. During the aligning phase with low-energy sonication, cavitation caused mild dysarthria and paresthesia, prompting treatment cessation. At the same time, tremor and rigidity improved. MRI revealed extensive high-intensity lesions in the thalamus 1 day after the procedure followed by steroid infusion, which resulted in resolution of adverse events. Tremor and rigidity improved 1.5 years after the procedure. Although cavitation can relieve tremors and rigidity, it should be carefully monitored due to potential permanent adverse events by unpredictable and unknown behaviors. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature. + + + + Yamaguchi + Toshio + T + http://orcid.org/0000-0002-0242-7345 + + International Academia for Focused Ultrasound Therapy, Katahira, Asaoku, Kawasaki, Kanagawa, 215-0023, Japan. yamaguchisurf@gmail.com. + + + Research Institute of Diagnostic Radiology, Shin-Yurigaoka General Hospital, Kawasaki, Kanagawa, Japan. yamaguchisurf@gmail.com. + + + + Nakano + Masayuki + M + + Department of Neurosurgery, Shin-Yurigaoka General Hospital, Kawasaki, Kanagawa, Japan. + + + + Sasanuma + Jinichi + J + + Department of Neurosurgery, Shin-Yurigaoka General Hospital, Kawasaki, Kanagawa, Japan. + + + + Takasaki + Masahito + M + + Department of Anesthesiology, Shin-Yurigaoka General Hospital, Kawasaki, Kanagawa, Japan. + + + + Maki + Futaba + F + + Department of Neurology, Shin-Yurigaoka General Hospital, Kawasaki, Kanagawa, Japan. + + + + Hino + Sakae + S + + Department of Neurology, Shin-Yurigaoka General Hospital, Kawasaki, Kanagawa, Japan. + + + + Kaburagi + Mayumi + M + + Department of Neurology, Shin-Yurigaoka General Hospital, Kawasaki, Kanagawa, Japan. + + + + Iijima + Ken + K + + International Academia for Focused Ultrasound Therapy, Katahira, Asaoku, Kawasaki, Kanagawa, 215-0023, Japan. + + + + Iwamuro + Hirokazu + H + + Department of Neurosurgery, Juntendo University, Bunkyo City, Tokyo, Japan. + + + + Watanabe + Kazuo + K + + Southern Tohoku Research Institute for Neuroscience, Koriyama, Fukushima, Japan. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Austria + Acta Neurochir (Wien) + 0151000 + 0001-6268 + + IM + + Cavitation + Focused ultrasound thalamotomy + Magnetic resonance–guided focused ultrasound + Mechanical bioeffect + Resting tremor + Tremor-dominant Parkinson’s disease + +
+ + + + 2022 + 11 + 29 + + + 2023 + 03 + 02 + + + 2023 + 3 + 14 + 12 + 19 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917360 + 10.1007/s00701-023-05551-4 + 10.1007/s00701-023-05551-4 + + + + Arvanitis CD, Vykhodtseva N, Jolesz F, Livingstone M, McDannold N (2016) Cavitation-enhanced nonthermal ablation in deep brain targets: feasibility in a large animal model. J Neurosurg 124:1450–1459. https://doi.org/10.3171/2015.4.Jns142862 + + 10.3171/2015.4.Jns142862 + 26381252 + + + + Bader KB, Vlaisavljevich E, Maxwell AD (2019) For whom the bubble grows: physical principles of bubble nucleation and dynamics in histotripsy ultrasound therapy. Ultrasound Med Biol 45:1056–1080. https://doi.org/10.1016/j.ultrasmedbio.2018.10.035 + + 10.1016/j.ultrasmedbio.2018.10.035 + 30922619 + 6524960 + + + + Chevillet JR, Khokhlova TD, Giraldez MD, Schade GR, Starr F, Wang YN, Gallichotte EN, Wang K, Hwang JH, Tewari M (2017) Release of cell-free microRNA tumor biomarkers into the blood circulation with pulsed focused ultrasound: a noninvasive, anatomically localized, molecular liquid biopsy. Radiology 283:158–167. https://doi.org/10.1148/radiol.2016160024 + + 10.1148/radiol.2016160024 + 27802108 + + + + Elias WJ, Lipsman N, Ondo WG, Ghanouni P, Kim YG, Lee W, Schwartz M, Hynynen K, Lozano AM, Shah BB, Huss D, Dallapiazza RF, Gwinn R, Witt J, Ro S, Eisenberg HM, Fishman PS, Gandhi D, Halpern CH, Chuang R, Butts Pauly K, Tierney TS, Hayes MT, Cosgrove GR, Yamaguchi T, Abe K, Taira T, Chang JW (2016) A randomized trial of focused ultrasound thalamotomy for essential tremor. N Engl J Med 375:730–739. https://doi.org/10.1056/NEJMoa1600159 + + 10.1056/NEJMoa1600159 + 27557301 + + + + Gateau J, Aubry JF, Pernot M, Fink M, Tanter M (2011) Combined passive detection and ultrafast active imaging of cavitation events induced by short pulses of high-intensity ultrasound. IEEE Trans Ultrason Ferroelectr Freq Control 58:517–532. https://doi.org/10.1109/tuffc.2011.1836 + + 10.1109/tuffc.2011.1836 + 21429844 + 3350371 + + + + Hardy J (2004) Historical background of stereotactic surgery: reflections on stereotactic surgery and the introduction of microelectrode recording in montreal. Neurosurgery 54:1508–1510. https://doi.org/10.1227/01.neu.0000125546.23705.22 . (discussion 1510-1501) + + 10.1227/01.neu.0000125546.23705.22 + 15157309 + + + + Hynynen K (1991) The threshold for thermally significant cavitation in dog’s thigh muscle in vivo. Ultrasound Med Biol 17:157–169. https://doi.org/10.1016/0301-5629(91)90123-e + + 10.1016/0301-5629(91)90123-e + 2053212 + + + + Jeanmonod D, Werner B, Morel A, Michels L, Zadicario E, Schiff G, Martin E (2012) Transcranial magnetic resonance imaging-guided focused ultrasound: noninvasive central lateral thalamotomy for chronic neuropathic pain. Neurosurg Focus 32:E1. https://doi.org/10.3171/2011.10.Focus11248 + + 10.3171/2011.10.Focus11248 + 22208894 + + + + Jung NY, Park CK, Kim M, Lee PH, Sohn YH, Chang JW (2018) The efficacy and limits of magnetic resonance-guided focused ultrasound pallidotomy for Parkinson's disease: a Phase I clinical trial. J Neurosurg 1–9. https://doi.org/10.3171/2018.2.Jns172514 + + + Khokhlova VA, Bailey MR, Reed JA, Cunitz BW, Kaczkowski PJ, Crum LA (2006) Effects of nonlinear propagation, cavitation, and boiling in lesion formation by high intensity focused ultrasound in a gel phantom. J Acoust Soc Am 119:1834–1848. https://doi.org/10.1121/1.2161440 + + 10.1121/1.2161440 + 16583923 + + + + Miller MW, Miller DL, Brayman AA (1996) A review of in vitro bioeffects of inertial ultrasonic cavitation from a mechanistic perspective. Ultrasound Med Biol 22:1131–1154. https://doi.org/10.1016/s0301-5629(96)00089-0 + + 10.1016/s0301-5629(96)00089-0 + 9123638 + + + + Nyborg WL (2001) Biological effects of ultrasound: development of safety guidelines. Part II: general review. Ultrasound Med Biol 27:301–333. https://doi.org/10.1016/s0301-5629(00)00333-1 + + 10.1016/s0301-5629(00)00333-1 + 11369117 + + + + Ohl CD, Arora M, Ikink R, de Jong N, Versluis M, Delius M, Lohse D (2006) Sonoporation from jetting cavitation bubbles. Biophys J 91:4285–4295. https://doi.org/10.1529/biophysj.105.075366 + + 10.1529/biophysj.105.075366 + 16950843 + 1635670 + + + + Tyler WJ (2011) Noninvasive neuromodulation with ultrasound? A continuum mechanics hypothesis. Neuroscientist 17:25–36. https://doi.org/10.1177/1073858409348066 + + 10.1177/1073858409348066 + 20103504 + + + + Xu Z, Carlson C, Snell J, Eames M, Hananel A, Lopes MB, Raghavan P, Lee CC, Yen CP, Schlesinger D, Kassell NF, Aubry JF, Sheehan J (2015) Intracranial inertial cavitation threshold and thermal ablation lesion creation using MRI-guided 220-kHz focused ultrasound surgery: preclinical investigation. J Neurosurg 122:152–161. https://doi.org/10.3171/2014.9.Jns14541 + + 10.3171/2014.9.Jns14541 + 25380106 + + + + Ye PP, Brown JR, Pauly KB (2016) Frequency dependence of ultrasound neurostimulation in the mouse brain. Ultrasound Med Biol 42:1512–1530. https://doi.org/10.1016/j.ultrasmedbio.2016.02.012 + + 10.1016/j.ultrasmedbio.2016.02.012 + 27090861 + 4899295 + + + + +
+ + + 36917352 + + 2023 + 03 + 14 + +
+ + 1432-0738 + + + 2023 + Mar + 14 + + + Archives of toxicology + Arch Toxicol + + Organoid-based 3D in vitro microphysiological systems as alternatives to animal experimentation for preclinical and clinical research. + 10.1007/s00204-023-03466-8 + + + Mukhopadhyay + Chrianjay + C + + Department of Microbiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India. + + + + Paul + Manash K + MK + http://orcid.org/0000-0002-9404-0024 + + Department of Microbiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India. manashp@ucla.edu. + + + Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA. manashp@ucla.edu. + + + + eng + + Editorial + + + 2023 + 03 + 14 + +
+ + Germany + Arch Toxicol + 0417615 + 0340-5761 + + IM +
+ + + + 2023 + 02 + 01 + + + 2023 + 02 + 16 + + + 2023 + 3 + 14 + 12 + 19 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917352 + 10.1007/s00204-023-03466-8 + 10.1007/s00204-023-03466-8 + + + + Akhtar A (2015) The flaws and human harms of animal experimentation. Camb Q Healthc Ethics 24(4):407–419. https://doi.org/10.1017/s0963180115000079 + + 10.1017/s0963180115000079 + 26364776 + 4594046 + + + + Andrews MG, Kriegstein AR (2022) Challenges of organoid research. Annu Rev Neurosci 45(1):23–39. https://doi.org/10.1146/annurev-neuro-111020-090812 + + 10.1146/annurev-neuro-111020-090812 + 34985918 + + + + Horejs C (2021) Organ chips, organoids and the animal testing conundrum. Nat Rev Mater 6(5):372–373. https://doi.org/10.1038/s41578-021-00313-z + + 10.1038/s41578-021-00313-z + 33936776 + 8072732 + + + + Leung CM, de Haan P, Ronaldson-Bouchard K, Kim G-A, Ko J, Rho HS, Chen Z, Habibovic P, Jeon NL, Takayama S, Shuler ML, Vunjak-Novakovic G, Frey O, Verpoorte E, Toh Y-C (2022) A guide to the organ-on-a-chip. Nat Rev Methods Primers. https://doi.org/10.1038/s43586-022-00118-6 + + 10.1038/s43586-022-00118-6 + + + + Mukherjee A, Sinha A, Maibam M, Bisht B, Paul K, M. (2022) Organoids and commercialization. Organoid Bioeng Adv Appl Chall. https://doi.org/10.5772/intechopen.104706 + + 10.5772/intechopen.104706 + + + + National Academies of Sciences E. and Medicine, Division on Earth and Life Studies, Institute for Laboratory Animal Research, Rose Li and Associates, Inc. (2021) Microphysiological systems. National Academies Press, Washington (DC). https://doi.org/10.17226/26124 + + + Sanyal R, Paul MK (2021) Organoid technology and the COVID pandemic. SARS-CoV-2 Origin COVID-19 Pandemic across Globe. https://doi.org/10.5772/intechopen.98542 + + 10.5772/intechopen.98542 + + + + Schutgens F, Clevers H (2020) Human organoids: tools for understanding biology and treating diseases. Annu Rev Pathol 15(1):211–234. https://doi.org/10.1146/annurev-pathmechdis-012419-032611 + + 10.1146/annurev-pathmechdis-012419-032611 + 31550983 + + + + van Berlo D, van de Steeg E, Amirabadi HE, Masereeuw R (2021) The potential of multi-organ-on-chip models for assessment of drug disposition as alternative to animal testing. Curr Opin Toxicol 27:8–17. https://doi.org/10.1016/j.cotox.2021.05.001 + + 10.1016/j.cotox.2021.05.001 + + + + Zhao Z, Chen X, Dowbaj AM, Sljukic A, Bratlie K, Lin L, Fong ELS, Balachander GM, Chen Z, Soragni A, Huch M, Zeng YA, Wang Q, Yu H (2022) Organoids. Nat Rev Methods Prim. https://doi.org/10.1038/s43586-022-00174-y + + 10.1038/s43586-022-00174-y + + + + +
+ + + 36917355 + + 2023 + 03 + 14 + +
+ + 1435-165X + + + 2023 + Mar + 14 + + + European child & adolescent psychiatry + Eur Child Adolesc Psychiatry + + Long-term cortisol secretion in attention deficit hyperactivity disorder: roles of sex, comorbidity, and symptom presentation. + 10.1007/s00787-023-02180-1 + + Low activity of the hypothalamic-pituitary-adrenal axis (HPAA) has been found in children with attention deficit hyperactivity disorder (ADHD). The condition may be related to the reduced attention regulation capacity and/or to comorbid oppositional defiant or conduct disorder (ODD/CD). Sex differences are probable but not sufficiently studied. We analyzed the HPAA activity and sympathetic nervous system reactivity (SR) in children with ADHD while accounting for ADHD symptom presentation, comorbidity, and sex differences. The sample comprised 205 children, 98 (61 boys, 37 girls) with ADHD and 107 (48 boys, 59 girls) healthy controls. DSM-5 phenotypic symptom presentation and comorbid ODD/CD were assessed using clinical interviews. Hair cortisol concentration (HCC) was used to assess the long-term, cumulative activity of the HPAA. SR was assessed via skin conductance response (SCR). For control purposes, comorbid internalizing symptoms and indicators of adverse childhood experiences (ACE) were assessed. Children were medication naive. Boys presenting with predominantly inattentive symptoms (ADHD-I) showed lower HCC than healthy boys. Girls presenting with combined symptoms (ADHD-C) showed higher HCC than did healthy girls (p's < 0.05, sex-by-group interaction, F (2,194) = 4.09, p = 0.018). Boys with ADHD plus ODD/CD showed a blunted SR (p < 0.001, sex-by-group interaction, F (2,172) = 3.08, p = 0.048). Adjustment for ACE indicators led to non-significant differences in HCC but did not affect differences in SR. HCC constitutes an easily assessable, reliable, and valid marker of phenotypic ADHD-related features (i.e. symptom presentation and comorbidity). It indicates more homogenous subgroups of ADHD and might point to specifically involved pathophysiological processes. + © 2023. The Author(s). + + + + Pauli-Pott + Ursula + U + + Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Philipps-University of Marburg, Schützenstrasse 45, 35039, Marburg, Germany. Ursula.pauli-pott@med.uni-marburg.de. + + + + Skoluda + Nadine + N + + Clinical Psychology, Department of Clinical and Health Psychology, Faculty of Psychology, University of Vienna, Liebiggasse 5, 1010, Vienna, Austria. + + + Research Platform The Stress of Life (SOLE)-Processes and Mechanisms underlying Everyday Life Stress, Vienna, Austria. + + + + Nater + Urs M + UM + + Clinical Psychology, Department of Clinical and Health Psychology, Faculty of Psychology, University of Vienna, Liebiggasse 5, 1010, Vienna, Austria. + + + Research Platform The Stress of Life (SOLE)-Processes and Mechanisms underlying Everyday Life Stress, Vienna, Austria. + + + + Becker + Katja + K + + Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Philipps-University of Marburg, Schützenstrasse 45, 35039, Marburg, Germany. + + + Center for Mind, Brain and Behavior (CMBB), University of Marburg Justus Liebig University Giessen, Hans-Meerwein-Straße 6, 35032, Marburg, Germany. + + + + Derz + Friederike + F + + Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Philipps-University of Marburg, Schützenstrasse 45, 35039, Marburg, Germany. + + + + Kaspar + Elena + E + + Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Philipps-University of Marburg, Schützenstrasse 45, 35039, Marburg, Germany. + + + + Kasperzack + Daria + D + + Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Philipps-University of Marburg, Schützenstrasse 45, 35039, Marburg, Germany. + + + + Kehm + Kira + K + + Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Philipps-University of Marburg, Schützenstrasse 45, 35039, Marburg, Germany. + + + + Kött + Marie + M + + Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Philipps-University of Marburg, Schützenstrasse 45, 35039, Marburg, Germany. + + + + Mann + Christopher + C + + Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Philipps-University of Marburg, Schützenstrasse 45, 35039, Marburg, Germany. + + + + Schurek + Pia + P + + Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Philipps-University of Marburg, Schützenstrasse 45, 35039, Marburg, Germany. + + + + Pott + Wilfried + W + + Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Philipps-University of Marburg, Schützenstrasse 45, 35039, Marburg, Germany. + + + + Schloß + Susan + S + + Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Philipps-University of Marburg, Schützenstrasse 45, 35039, Marburg, Germany. + + + + eng + + + Be2573/3-1, 3-2 + Deutsche Forschungsgemeinschaft + + + + Be2573/3-1, 3-2 + Deutsche Forschungsgemeinschaft + + + + Forschungsförderfond MR/17 + University of Marburg + + + + Forschungsförderfond MR/17 + University of Marburg + + + + Forschungsförderfond MR/17 + University of Marburg + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Eur Child Adolesc Psychiatry + 9212296 + 1018-8827 + + IM + + Attention deficit hyperactivity disorder + Hair cortisol concentration + Hypothalamic–pituitary–adrenal axis dysregulation + Oppositional defiant disorder + Sympathetic reactivity + +
+ + + + 2022 + 08 + 30 + + + 2023 + 02 + 27 + + + 2023 + 3 + 14 + 12 + 19 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917355 + 10.1007/s00787-023-02180-1 + 10.1007/s00787-023-02180-1 + + + + Scassellati C, Bonvicini C, Faraone SV, Gennarelli M (2012) Biomarkers and attention-deficit/hyperactivity disorder: a systematic review and meta-analyses. J Am Acad Child Adolesc Psychiatry 51(10):1003–1019 + + 10.1016/j.jaac.2012.08.015 + 23021477 + + + + Kamradt JM, Momany AM, Nikolas MA (2018) A meta-analytic review of the association between cortisol reactivity in response to a stressor and attention-deficit hyperactivity disorder. Adhd Attend Deficit 10(2):99–111. https://doi.org/10.1007/s12402-017-0238-5 + + 10.1007/s12402-017-0238-5 + + + + Bernhard A, Mayer JS, Fann N, Freitag CM (2021) Cortisol response to acute psychosocial stress in ADHD compared to conduct disorder and major depressive disorder: a systematic review. 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+ + + 36917357 + + 2023 + 03 + 14 + +
+ + 1573-2959 + + 195 + 4 + + 2023 + Mar + 14 + + + Environmental monitoring and assessment + Environ Monit Assess + + Moderation of nitrogen availability through the application of pyrolyzed and unpyrolyzed organic materials in saline water irrigated soil. + + 467 + + 10.1007/s10661-023-11052-9 + + Soil application of pyrolyzed biomass (biochar) has been proposed as an effective strategy for managing degraded land, but its limitations as a sole nutrient supplier discourage its widespread application as a soil amendment. Excessive use of saline water for irrigation leads to buildup of salts and other toxic ions, which cause a decline in the availability of essential nutrients due to negative effects on the mineralization process. Therefore, a long-term incubation experiment was conducted for 52 weeks to study the individual or combined impact of pyrolyzed [biochar derived from rice residue (RB)] and unpyrolyzed organic materials [rice residue (RR) and animal manure (AM)] on nitrogen (N) dynamics in soil irrigated with water of varying electrical conductivity (EC) (EC0.3 [non-saline canal water), EC10, and EC15 dS m-1 (saline)]. Increasing salinity had an adverse effect on N mineralization, reducing it by 20-70% during the incubation period. Irrespective of the EC, soil amended with AM showed greater and faster N mineralization than unamended control, while individual application of RB or RR showed immobilization of N during the early period of incubation. However, conjoint application of pyrolyzed (RB) and unpyrolyzed organic materials (RR or AM) showed enhanced mineralized N content (26-96%) compared with the sole biochar-amended soil irrigated with water of different EC levels. It was most likely due to the synergic effect of unpyrolyzed materials on the mineralization rate of biochar. On the other hand, the high cation exchange capacity, large surface area, and greater total porosity of the biochar may cause stronger adsorption of free NH4+-N released from the labile organic amendments, thereby moderating the N mineralization process under saline conditions. Therefore, it is recommended that biochar be used in conjunction with AM or RR to ensure the prolonged availability of N in a saline environment. + © 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG. + + + + Mavi + Manpreet Singh + MS + + Department of Soil Science, Punjab Agricultural University, Ludhiana, 141004, India. mavims16@pau.edu. + + + + Singh + Gurpreet + G + + Department of Soil Science, Punjab Agricultural University, Ludhiana, 141004, India. + + + + Choudhary + Om Parkash + OP + + Department of Soil Science, Punjab Agricultural University, Ludhiana, 141004, India. + + + + Dey + Debomita + D + + Department of Soil Science, Punjab Agricultural University, Ludhiana, 141004, India. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Netherlands + Environ Monit Assess + 8508350 + 0167-6369 + + IM + + Biochar + Conjoint application + Electrical conductivity + Nitrogen mineralization + Organic amendments + +
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+ + + 36917362 + + 2023 + 03 + 14 + +
+ + 0942-0940 + + + 2023 + Mar + 14 + + + Acta neurochirurgica + Acta Neurochir (Wien) + + PET imaging characteristics of neuromuscular choristoma and associated desmoid-type fibromatosis. + 10.1007/s00701-023-05547-0 + + Neuromuscular choristoma (NMC) is a rare peripheral nerve lesion characterized by abnormal presence of muscle within nerve. Associated desmoid-type fibromatosis (NMC-DTF) often develops. We report 18F-fluorodeoxyglucose positron emission tomography (FDG PET) characteristics of NMC and NMC-DTF and propose that increased FDG activity within NMCs may be associated with subclinical NMC-DTF or NMC-DTF "precursor" tissue. + Our institutional database was searched for all NMC cases. Inclusion criteria were 1) confirmed diagnosis of NMC with or without biopsy, and 2) available PET and MRI studies. PET data included SUVmax and SUVmean of NMCs, contralateral limb normal skeletal muscle and unaffected nerves, and SUVmax of NMC-DTF if present. SUV values were compared using paired t-test. A p value of < 0.05 was considered statistically significant. + Our cohort consisted of 9 patients with NMC, 8 cases involving sciatic nerve and 1 of brachial plexus. On PET imaging, all NMC-affected nerve segments showed significantly higher FDG uptake (SUVmax/mean) compared to both contralateral normal nerve and normal skeletal muscle (all P < 0.05). Similar to sporadic DTF, NMC-DTF was highly FDG-avid (average SUVmax of 4.2). SUVmax in NMC with or without concurrent NMC-DTF did not differ (p = 0.76). Within NMC-affected nerve segment, FDG activity was relatively higher in areas with low T1/T2 MR signal. + All NMCs were more FDG avid compared to both normal skeletal muscle and contralateral unaffected nerve, arguing against the presence of heterotopic muscle in NMC as the source of FDG avidity. FDG avidity within NMC may reflect subclinical NMC-DTF or a precursor lesion, as NMC-DTF are highly FDG-avid, and the highest regions of FDG avidity in NMC occurred in regions with MR characteristics associated with NMC-DTF (i.e., lower T1/T2 signal). We believe that the integration of FDG PET with serial MR imaging in patient follow up will clarify its utility in both detection and surveillance of NMC-DTF. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature. + + + + Marek + Tomas + T + + Department of Neurologic Surgery, Mayo Clinic, Gonda 8-214, Rochester, MN, 55905, USA. + + + Department of Radiology, University of Florida, Jacksonville, FL, USA. + + + + Spinner + Robert J + RJ + http://orcid.org/0000-0003-0443-7763 + + Department of Neurologic Surgery, Mayo Clinic, Gonda 8-214, Rochester, MN, 55905, USA. spinner.robert@mayo.edu. + + + + Carter + Jodi M + JM + + Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada. + + + + Murthy + Nikhil K + NK + + Department of Neurologic Surgery, UC San Diego Health, San Diego, CA, USA. + + + + Amrami + Kimberly K + KK + + Department of Radiology, Mayo Clinic, Rochester, MN, USA. + + + + Broski + Stephen M + SM + + Department of Radiology, Mayo Clinic, Rochester, MN, USA. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Austria + Acta Neurochir (Wien) + 0151000 + 0001-6268 + + IM + + Desmoid-type fibromatosis + FDG PET + Neuromuscular choristoma + Undergrowth + +
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+ + + 36917364 + + 2023 + 03 + 14 + +
+ + 1432-2048 + + 257 + 4 + + 2023 + Mar + 14 + + + Planta + Planta + + Cell corner middle lamella in hydroids of dendroid moss Hypnodendron menziesii gametophyte is prominently thickened: a proposed role in the mechanical support function. + + 82 + + 10.1007/s00425-023-04101-7 + + Significantly thickened corner middle lamella of the hydroid cell wall in the stipe of dendroid moss Hypnodendron menziesii has a mechanical support function. The hydroid cell walls of the erect stipe of Hypnodendron menziesii were investigated using light microscopy (LM), transmission electron microscopy (TEM), and TEM-immunogold labeling in support of the proposed biomechanical function for the highly thickened cell corner middle lamellae. The statistical analyses of dimensions of hydroid cell and wall parameters revealed a strong positive correlation between the area of hydroid cell and (i) the hydroid cell walls adhering to thick corner middle lamella, (ii) the area of the thick cell wall at hydroid corners, and (iii) the maximum thickness of cell wall at hydroid corners. The total area of the thick cell wall at the hydroid corners concomitantly increased with the area of the hydroid cell wall adhering to the middle lamella, and with the increased number of hydroids surrounding a reference hydroid. The results suggest that markedly thickened middle lamellae of the hydroid cell wall in Hypnodendron likely function by preventing hydroid cells from collapsing under the tensile forces generated from the transpirational pull on the water column. The specific localization of (1→4)- β-D-galactan and (1,5)-α-L-arabinan in the interface region of the hydroid cell wall and the thick middle lamella is consistent with these cell wall components being involved in the mechanical strengthening of the interface through firm adhesion as well as elasticity, ensuring the structural stability of this cell wall region, which may be prone to delamination/fracturing from the various internal and external pressures imposed. The copious presence of homogalacturonan in the thick middle lamella may further enhance the strength and flexibility of hydroid cell walls. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Chavan + Ramesh R + RR + http://orcid.org/0000-0003-2772-4749 + + School of Biological Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand. r.chavan@auckland.ac.nz. + + + + Singh + Adya P + AP + + School of Biological Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand. + + + + Turner + Adrian P + AP + http://orcid.org/0000-0001-5098-398X + + School of Biological Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
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+ + + 36917365 + + 2023 + 03 + 14 + +
+ + 2038-3312 + + + 2023 + Mar + 14 + + + Updates in surgery + Updates Surg + + Readmissions after emergent incisional ventral hernia repair: a retrospective review of the nationwide readmissions database. + 10.1007/s13304-023-01469-9 + + Emergent ventral hernia repair (eVHR) is associated with significant morbidity, yet there is no consensus regarding optimal surgical approach. We hypothesized that eVHR with synthetic mesh would have a higher readmission rate compared to primary eVHR or biologic mesh repair. Retrospective analysis of the Nationwide Readmissions Database (NRD) was conducted for patient entries between 2016 and 2018. Adult patients who underwent eVHR were included. Patient demographics, comorbidities, and surgical techniques were compared between readmitted and non-readmitted patients. Predictors of readmission were assessed using multivariate analysis with propensity weighting for various eVHR techniques. Secondary outcomes included hospital length of stay and readmission diagnoses. 43,819 patients underwent eVHR; of the 22,732 with 6 months of follow-up, 6382 (28.1%) were readmitted. The majority of readmissions occurred within the first 30 days (51.8%). Over half of the readmissions were related to surgical complications (50.6%), the most common being superficial surgical site infection (30.1%) and bowel obstruction/ileus (12.2%). In the multivariate analysis, predictors of 30-day readmission included use of synthetic mesh (OR 1.07, 95% CI 1.00-1.14), biologic mesh (OR 1.26, 95% CI 1.06-1.49), and need for concomitant large bowel resection (OR 1.46, 95% CI 1.30-1.65). eVHR is associated with high rates of readmission. Primary repair had favorable odds for readmission and lower risk of surgical complications compared to synthetic and biologic mesh repairs. Synthetic repair had lower odds of readmission than biologic repair. Given the inherent limitations of the NRD, further institutional prospective studies are required to confirm these findings. + © 2023. Italian Society of Surgery (SIC). + + + + Ricard + Caroline A + CA + http://orcid.org/0000-0001-7770-9892 + + Department of Surgery, Tufts Medical Center, Boston, MA, USA. cricard@tuftsmedicalcenter.org. + + + + Aalberg + Jeffrey J + JJ + + Department of Surgery, Tufts Medical Center, Boston, MA, USA. + + + + Bawazeer + Mohammed A + MA + + Emergency Surgical Services, Department of Surgery, Tufts Medical Center, Boston, MA, USA. + + + + Johnson + Benjamin P + BP + + Emergency Surgical Services, Department of Surgery, Tufts Medical Center, Boston, MA, USA. + + + + Hojman + Horacio M + HM + + Emergency Surgical Services, Department of Surgery, Tufts Medical Center, Boston, MA, USA. + + + + Kim + Woon Cho + WC + + Emergency Surgical Services, Department of Surgery, Tufts Medical Center, Boston, MA, USA. + + + + Mahoney + Eric J + EJ + + Emergency Surgical Services, Department of Surgery, Tufts Medical Center, Boston, MA, USA. + + + + Bugaev + Nikolay + N + + Emergency Surgical Services, Department of Surgery, Tufts Medical Center, Boston, MA, USA. + + + + eng + + + UL1TR002544 + Foundation for the National Institutes of Health + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + Italy + Updates Surg + 101539818 + 2038-131X + + IM + + Biologic mesh + Emergent hernia repair + Readmission + Synthetic mesh + Ventral hernia + +
+ + + + 2022 + 07 + 22 + + + 2023 + 02 + 17 + + + 2023 + 3 + 14 + 12 + 19 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917365 + 10.1007/s13304-023-01469-9 + 10.1007/s13304-023-01469-9 + + + + Beadles CA, Meagher AD, Charles AG (2015) Trends in emergent hernia repair in the United States. JAMA Surg 150(3):194–200 + + 10.1001/jamasurg.2014.1242 + 25564946 + + + + Ciarleglio FA, Rigoni M, Mereu L, Tommaso C, Carrara A, Malossini G et al (2021) The negative effects of COVID-19 and national lockdown on emergency surgery morbidity due to delayed access. World J Emerg Surg 16:37 + + 10.1186/s13017-021-00382-z + 34256781 + 8276199 + + + + Helgstrand F, Rosenberg J, Kehlet H, Bisgaard T (2013) Outcomes after emergency versus elective ventral hernia repair: a prospective nationwide study. 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Hernia 12(5):457–463 + + 10.1007/s10029-008-0374-0 + 18459033 + + + + Blatnik JA, Harth KC, Aeder MI, Rosen MJ (2011) Thirty-day readmission after ventral hernia repair: predictable or preventable? Surg Endosc 25(5):1446–1451 + + 10.1007/s00464-010-1412-4 + 20976493 + + + + Poruk KE, Farrow N, Azar F, Burce KK, Hicks CW, Azoury SC et al (2016) Effect of hernia size on operative repair and post-operative outcomes after open ventral hernia repair. Hernia 20(6):805–810 + + 10.1007/s10029-016-1542-2 + 27785629 + + + + +
+ + + 36917366 + + 2023 + 03 + 14 + +
+ + 2038-3312 + + + 2023 + Mar + 14 + + + Updates in surgery + Updates Surg + + Nationwide analysis of inpatient laparoscopic ventral hernia repair in Italy from 2015 to 2020. + 10.1007/s13304-023-01460-4 + + Since 2010, several guidelines and consensus papers have been proposed to support surgeons in the decision-making process (Cuccurullo et al. in Hernia 17(5):557-566, 2013; Silecchia et al. in Surg Endosc 29:2463-2484, 2015; Bittner et al. in Surg Endosc 33(11):3511-3549, 2015) with the conclusion that laparoscopic repair (LR) has gained popularity in the treatment of IH.To date, however, it is not yet clear as to the uptake of LR for IH on national basis. Only dated studies encompassing of all types of incisional hernia repairs are available in literature (Bisgaard et al. in Br J Surg 96:1452-1457, 2009). The aim of our study is to present a snapshot of Italian data for LR of ventral hernias, over a 6 years period, including volume of LR, procedural features and major postoperative outcomes. Data were extracted from the Italian Hospital Information System (HIS) that collects clinical and administrative information regarding each hospital admission of every patient discharged from any hospital in Italy. Using Hospital Discharge records regional Databases (HDD), all laparoscopic ventral hernia procedures carried out in public and private hospitals between 2015 and 2020, in patients over 18 years and resident in Italy, were collected based on diagnosis and procedure codes. The National Agency for Regional Health Services (AgeNaS) oversees the management and analysis of data. All hospital admissions that occurred between 2015 and 2020 were analyzed.A total of 154,546 incisional hernia repairs were performed in Italy from 2015 to 2020. Of these, 20,789 (13.45%) were minimally invasive repairs. The number of procedures performed increased significantly over time, constituting 11.96 and 15.24% of all procedures performed in 2015 and 2020 respectively. However, considering the whole period, the mean annual change was-5.58% (CI - 28.6% to 17.44%; p < 0.0001).Urgent minimally invasive repairs were performed in 1968 cases (1.27%). The absolute rate of laparoscopically treated patients needing an urgent surgical procedure increased overtime (from 7.36% in 2015 to 13.418% in 2020). The mean annual change registered over the whole period was 7.42%. 92% (CI - 0.03 to 14.09%; p < 0.0001). However, when considering the period from 2015 to 2019, the mean annual change was 10.42% (CI 6.35 to 14.49%; p < 0.0001). To our knowledge this is the first nationwide Italian report presenting the national workload of surgical units and the main perioperative features of minimally invasive surgery for ventral hernia repairs. + © 2023. The Author(s). + + + + Botteri + Emanuele + E + + General Surgery, ASST Spedali Civili di Brescia PO Montichiari, Via Boccalera, 325018, Montichiari, Brescia, Italy. + + + + Ortenzi + Monica + M + http://orcid.org/0000-0002-6508-6488 + + Department of General and Emergency Surgery, Università Politecnica Delle Marche, Piazza Roma 22, 60121, Ancona, Italy. monica.ortenzi@gmail.com. + + + + Williams + Sophie + S + + Colorectal Department, King's College Hospital, London, UK. + + + + Balla + Andrea + A + http://orcid.org/0000-0002-0182-8761 + + UOC of General and Minimally Invasive Surgery, Hospital "San Paolo", Largo Donatori del Sangue 1, 00053, Civitavecchia, RM, Italy. + + + + Podda + Mauro + M + + Department of Surgical Science, University of Cagliari, Cagliari, Italy. + + + + Guerrieri + Mario + M + + Department of General and Emergency Surgery, Università Politecnica Delle Marche, Piazza Roma 22, 60121, Ancona, Italy. + + + + Sartori + Alberto + A + + Department of General Surgery, Ospedale di Montebelluna, Via Palmiro Togliatti, 16, 31044, Montebelluna, TV, Italy. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Italy + Updates Surg + 101539818 + 2038-131X + + IM + + Laparoscopic + Nationwide analysis + Ventral hernia + +
+ + + + 2022 + 07 + 22 + + + 2023 + 02 + 10 + + + 2023 + 3 + 14 + 12 + 19 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917366 + 10.1007/s13304-023-01460-4 + 10.1007/s13304-023-01460-4 + + + + Bikhchandani J, Fitzgibbons RJ Jr (2013) Repair of giant ventral hernias. Adv Surg 47:1–27 + + 10.1016/j.yasu.2013.02.008 + 24298841 + + + + Bower C, Roth JS (2013) Economics of abdominal wall reconstruction. Surg Clin North Am 93:1241–1253 + + 10.1016/j.suc.2013.06.007 + 24035086 + + + + Cuccurullo D, Piccoli M, Agresta F, Magnone S, Corcione F, Stancanelli V, Melotti G (2013) Laparoscopic ventral incisional hernia repair: evidence-based guidelines of the first Italian consensus conference. Hernia 17(5):557–566 + + 10.1007/s10029-013-1055-1 + 23400528 + + + + Silecchia G, Campanile FC, Sanchez L (2015) Laparoscopic ventral/incisional hernia repair: updated guidelines from the EAES and EHS endorsed consensus development conference. Surg Endosc 29:2463–2484 + + 10.1007/s00464-015-4293-8 + 26139480 + + + + Bittner R, Bain K, Bansal VK (2019) Update of guidelines for laparoscopic treatment of ventral and incisionale hernia abdominal wall hernias (International endohernia society (IEHS)): part B. Surg Endosc 33(11):3511–3549 + + 10.1007/s00464-019-06908-6 + 31292742 + 6795640 + + + + Bisgaard T, Kehlet H, Bay-Nielsen MB (2009) Nationwide study of early outcomes after incisional hernia repair. Br J Surg 96:1452–1457 + + 10.1002/bjs.6728 + 19918863 + + + + Bracale U, Podda M, Castiglioni S, Peltrini R, Sartori A, Arezzo A, Corcione F, Agresta F, CLOUD-19 Collaborative Group (2021) Changes in surgical behaviors during the Covid-19 pandemic. The SICE CLOUD19 Study. Updates Surg 73(2):731–744 + + 10.1007/s13304-021-01010-w + 33656697 + 7926077 + + + + COVIDSurg Collaborative (2020) Elective surgery cancellations due to the COVID-19 pandemic: global predictive modelling to inform surgical recovery plans. Br J Surg 107(11):1440–1449 + + + Arezzo A, Francis N, Mintz Y, Adamina M, Antoniou SA, Bouvy N, Copaescu C, de Manzini N, Di Lorenzo N, Morales-Conde S, Müller-Stich BP, Nickel F, Popa D, Tait D, Thomas C, Nimmo S, Paraskevis D, Pietrabissa A, EAES Group of Experts for Recovery Amid COVID-19 Pandemic (2021) EAES recommendations for recovery plan in minimally invasive surgery amid COVID-19 pandemic. Surg Endosc 35(1):1–17 + + 10.1007/s00464-020-08131-0 + 33170335 + + + + Botteri E, Podda M, Sartori A (2020) The COVID-19 pandemic should not take us back to the prelaparoscopic era. J Trauma Acute Care Surg 89(2):273–274 + + 10.1097/TA.0000000000002783 + 32740638 + + + + Grafen FC, Neuhaus V, Schob O, Turina M (2010) Management of acute small bowel obstruction from intestinal adhesions: indications for laparoscopic surgery in a community teaching hospital. Langenbecks Arch Surg 395(1):57–63 + + 10.1007/s00423-009-0490-z + 19330347 + + + + Landau O, Kyzer S (2004) Emergent laparoscopic repair of incarcerated incisional and ventral hernia. Surg Endosc 18:1374–1376 + + 10.1007/s00464-003-9116-7 + 15164278 + + + + Franklin ME, Gonzalez JJ, Miter DB, Glass JL, Paulson D (2004) Laparoscopic diagnosis and treatment of intestinal obstruction. Surg Endosc 18:26–30 + + 10.1007/s00464-003-8804-7 + 14625729 + + + + Szomstein S, Lo Menzo E, Simpfendorfer C, Zundel N, Rosenthal R (2006) Laparoscopic lysis of adhesions. World J Surg 30:535–540 + + 10.1007/s00268-005-7778-0 + 16555020 + + + + Olmi S, Cesana G, Eba L, Croce E (2009) Emergency laparoscopic treatment of acute incarcerated incisional hernia. Hernia 3:605–608 + + 10.1007/s10029-009-0525-y + + + + Bessa SS, Abdel-Razek AH (2013) Results of prosthetic mesh repair in the emergency management of the acutely incarcerated and/or strangulated ventral hernias: a seven years study. Hernia 17(1):59–65 + + 10.1007/s10029-012-0938-x + 22733334 + + + + Sauerland S, Walgenbach M, Habermalz B, Seiler CM, Miserez M (2011) Laparoscopic versus open surgical techniques for ventral or incisional hernia repair. Cochrane Database Syst Rev 16(3):CD007781 + + + Eker HH, Hansson BM, Buunen M, Janssen IM, Pierik RE, Hop WC, Bonjer HJ, Jeekel J, Lange JF (2013) Laparoscopic vs. open incisional hernia repair: a randomized clinical trial. JAMA Surg 148:259–263 + + 10.1001/jamasurg.2013.1466 + 23552714 + + + + Forbes SS, Eskicioglu C, McLeod RS, Okrainec A (2009) Metaanalysis of randomized controlled trials comparing open and laparoscopic ventral and incisional hernia repair with mesh. Br J Surg 96:851–858 + + 10.1002/bjs.6668 + 19591158 + + + + Moreau PE, Helmy N, Vons C (2012) Laparoscopic treatment of incisional hernia. State of the art in 2012. J Vasc Surg 149(5 Suppl):e40–e48 + + + Kurian A, Gallagher S, Cheeyandira A, Josloff R (2010) Predictors of in-hospital length of stay after laparoscopic ventral hernia repair: results of multivariate logistic regression analysis. Surg Endosc 24:2789–2792 + + 10.1007/s00464-010-1048-4 + 20419324 + + + + +
+ + + 36917367 + + 2023 + 03 + 14 + +
+ + 1573-4978 + + + 2023 + Mar + 14 + + + Molecular biology reports + Mol Biol Rep + + SLC12A5 as a novel potential biomarker of glioblastoma multiforme. + 10.1007/s11033-023-08371-y + + Glioblastoma multiforme (GBM) is the most prevalent and malignant intracranial tumor with significant features of dismal prognosis and limited therapeutic solutions. Consequently, the present studies are committed to exploring potential biomarkers through bioinformatics analysis, which may serve as valuable prognostic predictors or novel therapeutic targets and provide new insights into the pathogenesis of GBM. + We filtered overlapping differentially expressed genes (DEGs) based on expression profilings from three GBM microarray datasets (GSE116520, GSE4290 and GSE68848) and combined RNA sequencing data from The Cancer Genome Atlas and the Genotype-Tissue Expression databases. Hub genes were prioritized from DEGs after performing protein-protein interaction (PPI) network analysis and weighted gene co-expression network analysis (WGCNA). This was followed by survival analysis to identify potential biomarkers among hub genes. Ultimately, the distributions of gene expressions, genetic alterations, upstream regulatory mechanisms and enrichments of gene functions of the identified biomarkers were analysed on public databases. QRT-PCR, immunohistochemical staining and western blotting was also used to confirm the gene expression patterns in GBM and normal brain tissues. CCK-8 assay clarified the effects of the genes on GBM cells. + A total of 322 common DEGs were determined and nine genes were subsequently considered as hub genes by the combination of PPI network analysis and WGCNA. Only SLC12A5 had prognostic significance, which was deficient in GBM whereas especially enriched in normal neural tissues. SLC12A5 overexpression would inhibit cell proliferation of U251MG. Genetic alterations of SLC12A5 were rarely seen in GBM patients, and there was no apparent association existed between SLC12A5 expression and DNA methylation. SLC12A5 was prominently involved in ion transport, synapse and neurotransmitter. + SLC12A5 shows promise to function as a novel effective biomarker for GBM and deserves further systematic research. + © 2023. The Author(s), under exclusive licence to Springer Nature B.V. + + + + Chen + Jiakai + J + + Department of Neurosurgery, Ningbo First Hospital, Ningbo, Zhejiang, China. + + + + Wang + Handong + H + http://orcid.org/0000-0002-6126-9631 + + Department of Neurosurgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China. njhdwang@hotmail.com. + + + + Deng + Chulei + C + + Department of Neurosurgery, Jinling Hospital, The First School of Clinical Medicine, Southern Medical University, Nanjing, Jiangsu, China. + + + + Fei + Maoxing + M + + Department of Neurosurgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China. + + + + eng + + + No.81672503 + This research was financially supported by the National Natural Science Foundation of China + + + + No.81702484 + This research was financially supported by the National Natural Science Foundation of China + + + + + Journal Article + + + 2023 + 03 + 14 + +
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+ + + 36917369 + + 2023 + 03 + 14 + +
+ + 1432-1955 + + + 2023 + Mar + 14 + + + Parasitology research + Parasitol Res + + Toxoplasmosis and cytomegalovirus infection and their role in Egyptian autistic children. + 10.1007/s00436-023-07818-2 + + Autism is a neurodevelopmental disorder with a significantly increased incidence rate across the world over the past few years. Toxoplasmosis and cytomegalovirus (CMV) infection are globally prevalent and have been associated with diverse neurological and psychiatric disorders. A few studies have demonstrated the role of toxoplasmosis and CMV as potential etiological factors for autism. Accordingly, this study was performed to estimate the relationship between toxoplasmosis and CMV infection in children with autism as well as to assess their impact on the Childhood Autism Rating Scale (CARS) score. A total of 45 autistic children (6 girls, 39 boys) and 45 (21 girls, 24 boys) healthy control children were enrolled in our study. Their blood samples were collected and tested for the presence of Toxoplasma and CMV (IgG and IgM) antibodies and DNA by ELISA and real-time PCR (RT-PCR), respectively. Toxoplasmosis was detected in 11 (24.4%) autistic children through the ELISA [10 (22.2%) IgG + /IgM - and 1 (2.2%) IgG + /IgM +]; however, RT-PCR assay recorded only 1 positive case (2.2%), while it was detected in 10 (22.2%) control children through ELISA [9 (20%) IgG + /IgM - and 1 (2.2%) IgG + /IgM +] and 1 (2.2%) by RT-PCR. On the other hand, CMV infection was detected in all autistic children with 44 (97.8%) testing positive by ELISA [24 (53.3%) IgG + /IgM - , 18 (40%) IgG + /IgM + and 2 (4.4%) IgG - /IgM +] and 25 (55.6%) testing positive by RT-PCR assay. In addition, ELISA assay recorded 43 (95.6%) [19 (42.2%) IgG + /IgM + and 22 (48.9%) IgG + /IgM - and 2 (4.4%) IgG-/IgM +] and RT-PCR recorded 21 (46.7%) positive samples in control children with CMV. No significant difference was noted between autistic and control children for the overall prevalence of Toxoplasma or/and CMV infection. Similarly, the CARS score indicated a non-significant difference with Toxoplasma or/and CMV infection. Our data does not show an association between autism and toxoplasmosis or/and CMV infection. Nevertheless, considering that autistic children are at a high risk of contracting these infections, further studies with a larger sample size are recommended. + © 2023. The Author(s). + + + + Hassan + Zeinab R + ZR + http://orcid.org/0000-0002-6767-6764 + + Department of Parasitology, Faculty of Medicine for girls, Al-Azhar University, Cairo, Egypt. zenabramadan.medg@azhar.edu.eg. + + + + Zekry + Kareman M + KM + + Department of Parasitology, Faculty of Medicine for girls, Al-Azhar University, Cairo, Egypt. + + + + Heikal + Elham Adel + EA + + Department of Parasitology, Faculty of Medicine for girls, Al-Azhar University, Cairo, Egypt. + + + + Ibrahim + Hanan F + HF + + Department of Medical Microbiology and Immunology, Faculty of Medicine for girls and boys, Al-Azhar University, Cairo, Egypt. + + + + Khirala + Seham K + SK + + Department of Medical Microbiology and Immunology, Faculty of Medicine for girls and boys, Al-Azhar University, Cairo, Egypt. + + + + Abd El-Hamid + Samar M + SM + + Department of Clinical Pathology, Al-Zahraa University Hospital,Faculty of Medicine for girls, Al-Azhar University, Cairo, Egypt. + + + + Amin + Doaa R + DR + + Department of Biochemistry, Faculty of Medicine for girls, Al-Azhar University, Cairo, Egypt. + + + + Seliem + Nora + N + + Department of Biochemistry, Faculty of Medicine for girls, Al-Azhar University, Cairo, Egypt. + + + + El-Aal + Gehad N Abd + GNA + + Department of Pediatric, Faculty of Medicine for girls, Al-Azhar University, Cairo, Egypt. + + + + Alkherkhisy + Mohammad M + MM + + Department of Medical Microbiology and Immunology, Faculty of Medicine for girls and boys, Al-Azhar University, Cairo, Egypt. + + + + Elhamid + Salwa A Abd + SAA + + Department of Pediatric, Faculty of Medicine, Ain Shams University, Cairo, Egypt. + + + + Mahgoub + Emad A + EA + + Department of Psychology, Faculty of Art, Cairo University, Cairo, Egypt. + + + + Hefny + Mahmoud E N + MEN + + Department of Psychological Sciences, Faculty of Education for Early Childhood, Cairo University, Cairo, Egypt. + + + + El Nady + Ghada H + GH + + Medical Genetic Center, Department of Medical Genetics, Faculty of Medicine, Ain Shams University, Cairo, Egypt. + + + + Badr + Mohamed S + MS + + Medical Research Centre, Department of Molecular Biology, Faculty of Medicine, Ain Shams University, Cairo, Egypt. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Parasitol Res + 8703571 + 0932-0113 + + IM + + Autism + CARS + CMV + ELISA + Prevalence + RT-PCR + Toxoplasmosis + +
+ + + + 2022 + 12 + 05 + + + 2023 + 03 + 03 + + + 2023 + 3 + 14 + 12 + 19 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917369 + 10.1007/s00436-023-07818-2 + 10.1007/s00436-023-07818-2 + + + + Abdoli A, Dalimi A, Arbabi M, Ghaffarifar F (2014) Neuropsychiatric manifestations of latent toxoplasmosis on mothers and their offspring. J Matern-Fetal Neo 27(13):1368–1374. https://doi.org/10.3109/14767058.2013.858685 + + 10.3109/14767058.2013.858685 + + + + Adeiza MA, Dalhat MM, Musa BOP, Muktar HM, Garko SB, Habib AG (2016) Seroepidemiology of cytomegalovirus antibodies in HIV-positive and HIV-negative adults in Nigeria. Sub Saharan Afr J Med 3(3):142–147. https://doi.org/10.4103/2384-5147.190852 + + 10.4103/2384-5147.190852 + + + + Afsharpaiman S, Skandari A, Maryam ZJ, Radfar S, Shirbazoo S, Amirsalari S, Torkaman M (2014) An assessment of Toxoplasmosis antibodies seropositivity in children suffering autism. 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IJPRR 4(1):1–4 + + + Siniscalco D, Schultz S, Brigida AL, Antonucci N (2018) Inflammation and neuro-immune dysregulations in autism spectrum disorders. Pharmaceuticals 11(2):56. https://doi.org/10.3390/ph11020056 + + 10.3390/ph11020056 + 29867038 + 6027314 + + + + Slawinski BL, Talge N, Ingersoll B, Smith A, Glazier A, Kerver J, Paneth N, Racicot K (2018) Maternal cytomegalovirus sero-positivity and autism symptoms in children. Am J Reprod Immunol 79(5):e12840. https://doi.org/10.1111/aji.12840 + + 10.1111/aji.12840 + 29520885 + 5978736 + + + + Spann MN, Sourander A, Surcel HM, Hinkka-Yli-Salomäki S, Brown AS (2017) Prenatal toxoplasmosis antibody and childhood autism. 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+ + + 36917374 + + 2023 + 03 + 14 + +
+ + 1863-6713 + + + 2023 + Mar + 14 + + + General thoracic and cardiovascular surgery + Gen Thorac Cardiovasc Surg + + A sealant with a hemostatic mechanism independent of the blood coagulation function was effective in both elective and emergency surgery for thoracic aorta. + 10.1007/s11748-023-01918-7 + + Matsudaito is a unique surgical sealant with a powerful hemostatic effect that works independent of a patient's blood coagulation function. Because of its mechanism, this sealant is expected to be particularly useful in patients with a poor blood coagulation function, such as in cases of acute aortic syndrome requiring emergency surgery. We, therefore, evaluated the hemostatic static effect of the sealant in both emergency and elective surgery of the thoracic aorta. + We used data obtained from post-marketing surveillance of the sealant. Patients who underwent replacement of the thoracic aorta were enrolled. The hemostatic effect was evaluated as effective if a further hemostatic procedure was not performed after applying the sealant. + From 46 hospitals in Japan, a total of 542 patients (327 elective and 215 emergency cases) were enrolled. Hospital mortality was 4.0% and 11.6% in elective and emergency cases, respectively (p < 0.05). Among the 1039 anastomoses (609 elective and 430 emergency cases), effective hemostasis was confirmed in 436 (71.6%) elective and 259 (60.2%) emergency cases. The data from the clinical trial of the sealant showed a hemostatic rate of 44.4% in elective control cases without the sealant. + Given that the hemostatic rate in emergency surgery with the sealant seemed to be better than that in elective surgery without the sealant (determined from the clinical trial), we concluded that the sealant was effective in both emergency and elective thoracic surgery of the aorta. + © 2023. The Author(s). + + + + Morita + Shigeki + S + http://orcid.org/0000-0001-6903-5429 + + Department of Cardiovascular Surgery, National Hospital Organization Kyushu Medical Center, Fukuoka, Fukuoka, 810-8563, Japan. morita.shigeki.mu@mail.hosp.go.jp. + + + + Yaku + Hitoshi + H + + Department of Cardiovascular Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Japan + Gen Thorac Cardiovasc Surg + 101303952 + 1863-6705 + + IM + + Acute aortic syndrome + Blood coagulation system + Surgical sealant + Thoracic aorta + Vascular anastomosis + +
+ + + + 2022 + 12 + 12 + + + 2023 + 02 + 12 + + + 2023 + 3 + 14 + 12 + 20 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917374 + 10.1007/s11748-023-01918-7 + 10.1007/s11748-023-01918-7 + + + + Coselli JS, Bavaria JE, Fehrenbacher J, Stowe CL, Macheers SK, Gundry SR. Prospective randomized study of a protein-based tissue adhesive used as a hemostatic and structural adjunct in cardiac and vascular anastomotic repair procedures. J Am Coll Surg. 2003;197:243–52. + + 10.1016/S1072-7515(03)00376-4 + 12892806 + + + + Borst HG, Haverich A, Walterbusch G, Maatz W. Fibrin adhesive: an important hemostatic adjunct in cardiovascular operations. J Thorac Cardiovasc Surg. 1982;84:548–53. + + 10.1016/S0022-5223(19)38982-2 + 6981733 + + + + Bachet J, Goudot B, Dreyfus G, Banfi C, Ayle NA, Aota M, et al. The proper use of glue: a 20-year experience with the GRF glue in acute aortic dissection. J Card Surg. 1997;12:243–53. + + 9271753 + + + + Lumsden AB, Heyman ER. Prospective randomized study evaluating an absorbable cyanoacrylate for use in vascular reconstructions. J Vasc Surg. 2006;44:1002–9. + + 10.1016/j.jvs.2006.06.039 + 17020801 + + + + Horowitz B, Busch M. Estimating the pathogen safety of manufactured human plasma products: application to fibrin sealants and to thrombin. Transfusion. 2008;48:1739–53. + + 10.1111/j.1537-2995.2008.01717.x + 18466171 + 7201864 + + + + Cardillo G, Carleo F, Carbone L, De Massimi R, Lococo A, Santini PF, et al. Adverse effects of fibrin sealants in thoracic surgery: the safety of a new fibrin sealant: multicentre, randomized, controlled, clinical trial. Eur J Cardiothorac Surg. 2012;41:657–62. + + 10.1093/ejcts/ezr083 + 22219405 + + + + Weiner J, Widman S, Golek Z, Tranquilli M, Elefteriades JA. Role of Bovine Serum albumin-glutaraldehyde glue in the formation of anastomatic pseudoaneurysms. J Card Surg. 2011;26:76–81. + + 10.1111/j.1540-8191.2010.01162.x + 21114528 + + + + Fujiwara H, Oda K, Saiki Y, Sakamoto N, Ohashi T, Sato M, et al. The wrapping method using biodegradable felt strips has a preventive effect on the thinning of the aortic wall: Experimental study in the canine aorta. J Vasc Surg. 2006;43:349–56. + + 10.1016/j.jvs.2005.09.044 + 16476614 + + + + Oda S, Morita S, Tanoue Y, Eto M, Matsuda T, Tominaga R. Experimental use of an elastomeric surgical sealant for arterial hemostasis and its long-term tissue response. Interact Cardiovasc Thorac Surg. 2010;10:258–61. + + 10.1510/icvts.2009.217620 + 19934160 + + + + Matsuda T, Nakajima N, Itoh T, Takakura T. Development of a compliant surgical adhesive derived from novel fluorinated hexamethylene diisocyanate. ASAIO Trans. 1989;35:381–3. + + 10.1097/00002216-198907000-00068 + 2557069 + + + + Morita S, Matsuda T, Tashiro T, Komiya T, Ogino H, Mukohara N, et al. Randomized clinical trial of an elastomeric sealant for hemostasis in thoracic aortic surgery. Gen Thorac Cardiovasc Surg. 2020;68:112–21. + + 10.1007/s11748-019-01169-5 + 31300951 + + + + Ministry of Health Labor and Welfare of Japan. Ministry ordinance of the guidance regarding post marketing surveyance of the drugs and medical equipment. https://Elaws.e-GovGoJp/Document?Lawid=416M60000100171 n.d. (26 June 2022, Date Last Accessed) + + + Shimizu H, Okada M, Tangoku A, Doki Y, Endo S, Fukuda H, et al. Thoracic and cardiovascular surgeries in Japan during 2017: Annual report by the Japanese Association for Thoracic Surgery. Gen Thorac Cardiovasc Surg. 2020;68:414–49. + + 10.1007/s11748-020-01298-2 + 32140991 + + + + Basu S, Marini CP, Bauman FG, Shirazian D, Damiani P, Robertazzi R, et al. Comparative study of biological glues: cryoprecipitate glue, two-component fibrin sealant, and “French” glue. Ann Thorac Surg. 1995;60:1255–62. + + 10.1016/0003-4975(95)00599-G + 8526609 + + + + Nenezić D, Ayguasanosa J, Menyhei G, Tamás H, Mátyás L, Muluk S, et al. A prospective, single-blind, randomized, phase III study to evaluate the safety and efficacy of Fibrin Sealant Grifols as an adjunct to hemostasis compared with manual compression in vascular surgery. J Vasc Surg. 2019;70:1642–51. + + 10.1016/j.jvs.2018.12.051 + 30926276 + + + + Minato N, Katayama Y, Yunoki J, Kawasaki H, Satou H. Hemostatic effectiveness of a new application method for fibrin glue, the “rub-and-spray method”, in emergency aortic surgery for acute aortic dissection. Ann Thorac Cardiovasc Surg. 2009;15:265–71. + + 19763062 + + + + Ueda T, Shimizu H, Hashizume K, Koizumi K, Mori M, Shin H, et al. Mortality and morbidity after total arch replacement using a branched arch graft with selective antegrade cerebral perfusion. Ann Thorac Surg. 2003;76:1951–6. + + 10.1016/S0003-4975(03)01136-6 + 14667620 + + + + Antonios VS, Baddour LM. Intra-arterial device infections. Curr Infect Dis Rep. 2004;6:263–9. + + 10.1007/s11908-004-0046-x + 15265453 + + + + Oda T, Minatoya K, Kobayashi J, Okita Y, Akashi H, Tanaka H, et al. Prosthetic vascular graft infection through a median sternotomy: A multicentre review. Interact Cardiovasc Thorac Surg. 2015;20:701–6. + + 10.1093/icvts/ivv024 + 25724196 + + + + Nakae M, Toda K, Yoshioka D, Miyagawa S, Kainuma S, Kawamura T, et al. Sutureless patch repair with a novel adhesive for postinfarction ventricular septal rupture. Ann Thorac Surg. 2022;113:e33–6. + + 10.1016/j.athoracsur.2021.03.051 + 33794161 + + + + Ishii H, Endo H, Tsuchiya H, Inaba Y, Terakawa K, Kubota H. Off-pump hemostasis for left ventricular rupture after myocardial infarction with Hydrofit ® and Surgicel ®. Gen Thorac Cardiovasc Surg. 2018;66:753–5. + + 10.1007/s11748-018-0928-8 + 29693223 + + + + Umeda Y. Distal stump construction for acute aortic dissection by pre-gluing felt strip with Hydrofit® during systemic cooling. J Cardiovasc Surg (Torino). 2021;62:408–10. + + 33688709 + + + + Kawashima T, Hatori K, Mizoguchi T, Oda Y, Arakura M, Hagiwara N, et al. In vitro evaluation of the hemostatic effect of method involving the combined use of Hydrofit ® and Spongel ®. Gen Thorac Cardiovasc Surg. 2020;68:932–7. + + 10.1007/s11748-019-01282-5 + 31893336 + + + + Shimura S, Odagiri S, Okada K, Keisuke O, Takayoshi Y, Goro K, et al. Closure of aortic root false lumen using Hydrofit in type A acute aortic dissection (Abstract in Japanese). Japanese J Vasc Surg. 2020;29:22–5. + + + +
+ + + 36917368 + + 2023 + 03 + 14 + +
+ + 1573-4978 + + + 2023 + Mar + 14 + + + Molecular biology reports + Mol Biol Rep + + Nicotiana hairy roots for recombinant protein expression, where to start? A systematic review. + 10.1007/s11033-023-08360-1 + + Hairy roots are a plant-tissue culture raised by Rhizobium rhizogenes infection (formerly known as Agrobacterium rhizogenes). Nowadays, these roots have been gaining more space in biotechnology due to their benefits for the recombinant expression of valuables proteins; it includes simplified downstream processing, protein rhizosecretion, and scalability in bioreactors. However, due to methodological inconsistency among reports, the tissue platform is still a promising technology. + In the current paper, we propose the first step to overcome this issue through a systematic review of studies that employ Nicotiana hairy roots for recombinant expression. We conducted a qualitative synthesis of 36 out of 387 publications initially selected. Following the PRISMA procedure, all papers were assessed for exclusion and inclusion criteria. Multiple points of root culture were explored, including transformation methods, root growth curve, external additives, and scale-up with bioreactors to determine which approaches performed best and what is still required to achieve a robust protocol. + The information presented here may help researchers who want to work with hairy roots in their laboratories trace a successful path to appraisal the literature status. + © 2023. The Author(s), under exclusive licence to Springer Nature B.V. + + + + Aragão + M M + MM + + Departamento de Biologia, ICB - Universidade Federal de Juiz de Fora,, R. José Lourenço Kelmer, S/N, Juiz de Fora, MG, Brazil. + + + + Alvarez + M A + MA + + CONICET - Universidade Maimónides (CEBBAD), Hidalgo 775, Lab 603, Buenos Aires, Argentina. + + + + Caiafa + L + L + + Programa de Pós-Graduação em Biodiversidade e Conservação da Natureza, Universidade Federal de Juiz de Fora, R. José Lourenço Kelmer, S/N, Juiz de Fora, MG, Brazil. + + + + Santos + M O + MO + http://orcid.org/0000-0003-4909-2252 + + Departamento de Biologia, ICB - Universidade Federal de Juiz de Fora,, R. José Lourenço Kelmer, S/N, Juiz de Fora, MG, Brazil. marcelo.santos@ufjf.br. + + + + eng + + + Finance Code 001 + Coordenação de Aperfeiçoamento de Pessoal de Nível Superior + + + + + Journal Article + Review + + + 2023 + 03 + 14 + +
+ + Netherlands + Mol Biol Rep + 0403234 + 0301-4851 + + IM + + Hairy roots + Heterologous expression + Recombinant protein + Rhizobium rhizogenes + +
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Front Plant Sci 10:452. https://doi.org/10.3389/fpls.2019.00452 + + 10.3389/fpls.2019.00452 + 31031788 + 6470201 + + + + Rage E, Marusic C, Lico C, Salzano AM, Scaloni A, Baschieri S, Donini M (2020) Optimisation of PD-FcY veterinary antigen secretion from Nicotiana benthamiana hairy roots and purification from the culture medium. PCTOC 142(1):23–39. https://doi.org/10.1007/s11240-020-01826-1 + + 10.1007/s11240-020-01826-1 + + + + Gurusamy PD, Schäfer H, Ramamoorthy S, Wink M (2017) Biologically active recombinant human erythropoietin expressed in hairy root cultures and regenerated plantlets of Nicotiana tabacum L. PLoS ONE 12(8):e0182367. https://doi.org/10.1371/journal.pone.0182367 + + 10.1371/journal.pone.0182367 + 28800637 + 5553650 + + + + Gaume A, Komarnytsky S, Borisjuk N, Raskin I (2003) Rhizosecretion of recombinant proteins from plant hairy roots. 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+ + 1573-6571 + + + 2023 + Mar + 14 + + + Journal of religion and health + J Relig Health + + "The First Person They Call is Their Pastor": The Role of New York City Faith Leaders in Supporting Their Congregation's Health and Well-Being During COVID-19. + 10.1007/s10943-023-01789-5 + + This article reports findings from a qualitative study of New York City faith leaders' efforts to mitigate the effects of the COVID-19 pandemic on their communities during the first two years of the pandemic. Faith leaders were recruited via reputational case sampling to participate in individual, key informant interviews. This study used a social-contextual approach to health promotion by exploring the influence of faith leaders and religious communities on health behaviors. Results suggest that engaged faith leaders worked individually and collaboratively to support the changing physical, emotional, and spiritual needs of their religious communities and those in the surrounding area. This study highlights the importance of faith leaders as supporters, communicators, and advocates, and provides directions for future research on the impact of faith leaders on individuals' experiences and health behaviors during a pandemic. + © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. + + + + Sklar + Rachel P + RP + http://orcid.org/0000-0002-6476-6043 + + Division of Biology and Medicine, Brown University, Providence, RI, USA. rachel.p.sklar@gmail.com. + + + + Goldman + Roberta E + RE + + Warren Alpert Medical School, Brown University, Providence, RI, USA. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + J Relig Health + 2985199R + 0022-4197 + + IM + + COVID-19 + Faith leader + New York City + Public health + +
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Now they are confronting coronavirus cases. The New York Times. https://www.nytimes.com/2020/07/08/us/coronavirus-churches-outbreaks.html + + + del Castillo, F. A., Biana, H. T., & Joaquin, J. J. B. (2020). ChurchInAction: The role of religious interventions in times of COVID-19. Journal of Public Health, 42(3), 633–634. https://doi.org/10.1093/pubmed/fdaa086 + + 10.1093/pubmed/fdaa086 + + + + de Oliveira Maraldi, E. (2020). Response bias in research on religion, spirituality and mental health: A critical review of the literature and methodological recommendations. Journal of Religion and Health, 59(2), 772–783. https://doi.org/10.1007/s10943-018-0639-6 + + 10.1007/s10943-018-0639-6 + 29770899 + + + + Devers, K. J., & Frankel, R. M. (2000). Study design in qualitative research—2: sampling and data collection strategies. Education for Health, 13(2), 263–271. + + 10.1080/13576280050074543 + 14742088 + + + + Dias, E. (2020a, March 15). A sunday without church: In Crisis, a Nation Asks, ‘What is community?’ The New York Times. https://www.nytimes.com/2020a/03/15/us/churches-coronavirus-services.html + + + Estrin, J. (2020b, May 20). How a queens pastor tends to his flock from six feet away. The New York Times. https://www.nytimes.com/2020b/05/20/nyregion/coronavirus-catholic-church-nyc.html + + + Faith leaders use trusted voices to encourage vaccination. (2021, December 6). https://about.kaiserpermanente.org/community-health/news/faith-leaders-use-trusted-voices-to-encourage-vaccination + + + Flórez, K. R., Payán, D. D., Palar, K., Williams, M. V., Katic, B., & Derose, K. P. (2020). Church-based interventions to address obesity among African Americans and Latinos in the United States: A systematic review. Nutrition Reviews, 78(4), 304–322. https://doi.org/10.1093/nutrit/nuz046 + + 10.1093/nutrit/nuz046 + 31539069 + + + + Galiatsatos, P., Monson, K., Oluyinka, M., Negro, D., Hughes, N., Maydan, D., Golden, S. 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HIV/AIDS disparity between African-American and Caucasian men who have sex with men: intervention strategies for the black church. Journal of Religion and Health, 52(2), 475–487. https://doi.org/10.1007/s10943-011-9496-2 + + 10.1007/s10943-011-9496-2 + 21538178 + + + + Hoffman, J. (2021, March 14). Clergy preach faith in the covid vaccine to doubters. The New York Times. https://www.nytimes.com/2021/03/14/health/clergy-covid-vaccine.html + + + Holmes, M. R., Rentrope, C. R., Korsch-Williams, A., & King, J. A. (2021). Impact of COVID-19 pandemic on posttraumatic stress, grief, burnout, and secondary trauma of social workers in the United States. Clinical Social Work Journal, 49(4), 495–504. https://doi.org/10.1007/s10615-021-00795-y + + 10.1007/s10615-021-00795-y + 33678920 + 7922703 + + + + Hovey, J. D., Hurtado, G., Morales, L. R. A., & Seligman, L. D. (2014). Religion-based emotional social support mediates the relationship between intrinsic religiosity and mental health. 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+ + + 36917379 + + 2023 + 03 + 14 + +
+ + 1614-7499 + + + 2023 + Mar + 14 + + + Environmental science and pollution research international + Environ Sci Pollut Res Int + + The monetary facilities payment for ecosystem services as an approach to restore the Degraded Urmia Lake in Iran. + 10.1007/s11356-023-26134-x + + This study analyzed the potential use of Payment for Ecosystem Services (PES) as a strategy for improving water supply management. This study focused on the Siminehroud Sub-basin due to its high importance to the Basin of Urmia Lake (UL). Siminehroud is the second provider of water (by volume) to Urmia Lake. To evaluate the technical and economic feasibility of a PES scheme, the current land use map was extracted using satellite imagery. In addition, the two algorithms of Support Vector Machines (SVMs) and Maximum Likelihood (ML) are used for Landsat images classification, rather than analyzing the relationship between land use and ecosystem services. Then, the most relevant ecosystem services provided in the region were evaluated using the Benefit Transfer Method. In the last step, by designing and implementing a survey, on the one hand, the local farmers' Willingness to Accept (WTA) cash payments for reducing the area they cultivate, and on the other hand, the farmers' Willingness to Pay (WTP) for managing the water consumption were determined. The results illustrated that the WTA program is more acceptable among the beneficiaries. It is also notable that this program needs very high governmental funding. Furthermore, the results of the program indicate that the land area out of the cultivation cycle will gradually increase while the price of agricultural water will also increase. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Daneshi + Alireza + A + + Department of Watershed Management Sciences and Engineering, Gorgan University of Agricultural Sciences & Natural Resources, Gorgan, Iran. + + + + Azadi + Hossein + H + http://orcid.org/0000-0002-5108-1993 + + Department of Economics and Rural Development, Gembloux Agro-Bio Tech, University of Liège, Gembloux, Belgium. hossein.azadi@uliege.be. + + + + Panahi + Mostafa + M + + Faculty of Natural Resources and Environment, Science and Research Branch, Islamic Azad University, Tehran, Iran. + + + + Islami + Iman + I + + Department of Rangeland Management, Faculty of Natural Resources, Tarbiat Modares University, Nour, Iran. + + + + Vafakhah + Mehdi + M + + Department of Watershed Management Engineering, Faculty of Natural Resources, Tarbiat Modares University, Nour, Iran. + + + + Mirzaeipour + Zahra + Z + + Department of Environment, Alborz Campus, University of Tehran, Tehran, Iran. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Environ Sci Pollut Res Int + 9441769 + 0944-1344 + + IM + + Economic analysis + Payment for ecosystem services + Water management + Willingness to accept + Willingness to pay + +
+ + + + 2022 + 06 + 25 + + + 2023 + 02 + 21 + + + 2023 + 3 + 14 + 12 + 20 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917379 + 10.1007/s11356-023-26134-x + 10.1007/s11356-023-26134-x + + + References + + Abbaspour M, Nazaridoust A (2007) Determination of environmental water requirements of Lake Urmia, Iran: An ecological approach. Int J Environ Stud 64:161–169 + + 10.1080/00207230701238416 + + + + Abdulkarim B, Yacob MR, Abdullahi AMH, Radam A (2016) Farmers Willingness to Pay for Water Ecosystem Services Toward Forest Conservation in North West Selangor Malaysia. Int J Econ Commer Manag 5:319–333 + + + Agha M, Yackulic CB, Riley MK, Peterson B, Todd BD (2020) Brackish tidal marsh management and the ecology of a declining freshwater turtle. 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+ + + 36917373 + + 2023 + 03 + 14 + +
+ + 1741-0444 + + + 2023 + Mar + 14 + + + Medical & biological engineering & computing + Med Biol Eng Comput + + Enhancing retinal images in low-light conditions using semidecoupled decomposition. + 10.1007/s11517-023-02811-4 + + Eye diseases that are common and many diseases that result in visual ailments, such as diabetes and vascular disease, can be diagnosed through retinal imaging. The enhancement of retinal images often helps in diagnosing diseases related to retinal organ failure. However, today's image enhancement methods may lead to artificial boundaries, sudden color gradation, and the loss of image details. Therefore, to prevent these side effects, a new method of retinal image enhancement is proposed. In this work, we propose a new method for enhancing the overall contrast of colored retinal images. That is, we propose low-light image enhancement using a new retinex method based on a powerful semidecoupled retinex method. In particular, illumination layer I gradually approximates the S input image according to the file. This leads to a complete Gaussian transformation model, while the R-layer reflectance is estimated jointly by S and intermediary by I to suppress image noise simultaneously during R estimation on the publicly available Messidor database. From our assessment measurements (PSNR and SSIM), we show that this proposed method is effective in comparison with the relevant and recently proposed retinal imaging methods; moreover, the color, which is determined by the data, does not change the image structure. Finally, a technique is presented to improve the pronounced color of a retinal image, which is useful for ophthalmologists to screen for retinal disease more effectively. Moreover, this technique can be used in the development of robotics for imaging tests to search for clinical markers. + © 2023. International Federation for Medical and Biological Engineering. + + + + WangNo + Nitit + N + http://orcid.org/0000-0002-9876-0889 + + Major of Computer and Information Technology, Faculty of Information Technology, Roi Et Rajabhat University, Roi Et, Thailand. nitit@kkumail.com. + + + + Pichai + Supailin + S + + Major of Computer Science, Department of Applied Science, Faculty of Science and Technology, Loei Rajabhat University, Loei, Thailand. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Med Biol Eng Comput + 7704869 + 0140-0118 + + IM + + Image enhancement + Low-light images + Retinal image + Semidecoupled + +
+ + + + 2021 + 07 + 09 + + + 2023 + 02 + 22 + + + 2023 + 3 + 14 + 12 + 19 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917373 + 10.1007/s11517-023-02811-4 + 10.1007/s11517-023-02811-4 + + + + Abramoff MD, Garvin MK, Sonka M (2010) Retinal imaging and image analysis. IEEE Rev Biomed Eng 3:169–208 + + 10.1109/RBME.2010.2084567 + 22275207 + 3131209 + + + + Bolun C, Xianming X, Kailing G, Kui J, Bin H, Dacheng T (2017) A joint intrinsic-extrinsic prior model for retinex. In IEEE International Conference on Computer Vision, ICCV 2017, Venice, Italy, October 22–29,4020–4029 + + + Chen B, Chen Y, Shao Z, Tongd T, Luo L (2016) Blood vessel enhancement via multi-dictionary and sparse coding: application to retinal vessel enhancing. Neurocomputing 200:110–117 + + 10.1016/j.neucom.2016.03.012 + + + + Decenciere E et al (2014) Feedback on a publicly distributed image database: the Messidor database. Image Anal Stereol 33(3):231–234 + + 10.5566/ias.1155 + + + + Fenga P, Pana Y, Weia B, Jin W, Mi D (2007) Enhancing retinal image by the Contourlet transform. Pattern Recogniton Lett 28(4):516–522 + + 10.1016/j.patrec.2006.09.007 + + + + Foracchia M, Grisan E, Ruggeri A (2005) Luminosity and contrast normalization in retinal images. Med Image Anal 9(3):179–190 + + 10.1016/j.media.2004.07.001 + 15854840 + + + + Fu X, Liao Y, Zeng D, Huang Y, Zhang X-P, Ding X (2015) A probabilistic method for image enhancement with simultaneous illumination and reflectance estimation. IEEE transactions on image processing : a publication of the IEEE Signal Processing Society 24. https://doi.org/10.1109/TIP.2015.2474701 + + + GeethaRamani R, Balasubramanian L (2016) Retinal blood vessel segmentation employing image processing and data mining techniques for computerized retinal image analysis. Biocybernetics Biomed Eng 36(1):102–118 + + 10.1016/j.bbe.2015.06.004 + + + + Gupta B, Tiwari M (2019) Color retinal image enhancement using luminosity and quantile based contrast enhancement. Multidim Syst Sign Process 30:1829–1837. https://doi.org/10.1007/s11045-019-00630-1 + + 10.1007/s11045-019-00630-1 + + + + Liao M, Zhao Y, Wang X, Dai P (2014) Retinal vessel enhancement based on multi-scale top-hat transformation and histogram fitting stretching. Opt Laser Technol 58:56–62 + + 10.1016/j.optlastec.2013.10.018 + + + + Li M, Liu J, Yang W, Sun X, Guo Z (2018) Structure-revealing low-light image enhancement via robust retinex model. IEEE Trans Image Processing : Pub IEEE Signal Proces Soc 27(6):2828–2841. https://doi.org/10.1109/TIP.2018.2810539 + + 10.1109/TIP.2018.2810539 + + + + Pisano ED, Zong S, Hemminger BM, DeLuca M, Johnston RE, Muller K et al (1998) Contrast limited adaptive histogram equalization image processing to improve the detection of simulated spiculations in dense mammograms. J Digit Imaging 11(4):193–200 + + 10.1007/BF03178082 + 9848052 + 3453156 + + + + Rudin LI, Osher S, Fatemi E (1992) Nonlinear total variation based noise removal algorithms. Phys D 60:259–268. https://doi.org/10.1016/0167-2789(92)90242-F + + 10.1016/0167-2789(92)90242-F + + + + Seoud L, Hurtut T, Chelbi J, Cheriet F, Langlois JMP (2016) Red lesion detection using dynamic shape features for diabetic retinopathy screening. IEEE Trans Med Imaging 35(4):1116–1126. https://doi.org/10.1109/TMI.2015.2509785 + + 10.1109/TMI.2015.2509785 + 26701180 + + + + Sevik U, Kose C, Berber T, Erdol H (2014) Identification of suitable fundus images using automated quality assessment methods. J Biomed Opt 19(4):046006 + + 10.1117/1.JBO.19.4.046006 + 24718384 + + + + Somkuwar AC, Patil TG, Patankar SS, Kulkarni JV (2015) Intensity features based classification of hard exudates in retinal images. In 2015 annual IEEE India conference (INDICON), New Delhi (1–5). https://doi.org/10.1109/INDICON.2015.7443402 + + + Wang S, Zheng J, Hu HM, Li B (2013) Naturalness preserved enhancement algorithm for non-uniform illumination images. IEEE Trans Image Process 22(9):3538–3548 + + 10.1109/TIP.2013.2261309 + 23661319 + + + + Wu X, Dai B, Bu W (2016) Optic disc localization using directional models. IEEE Trans Image Proces 25(9):4433–4442. https://doi.org/10.1109/TIP.2016.2590838 + + 10.1109/TIP.2016.2590838 + + + + Yue H, Yang J, Sun X, Hou C (2017) Contrast enhancement based on intrinsic image decomposition. IEEE Transactions on Image Processing. 1–1. https://doi.org/10.1109/TIP.2017.2703078 + + + Zhang Q, Yuan G, Xiao C, Zhu L & Zheng W (2018) High-quality exposure correction of underexposed photos. Proceedings of the 26th ACM international conference on Multimedia + + + Zhou M, Jin K, Wang S, Ye J, Qian D (2018) Color retinal image enhancement based on luminosity and contrast adjustment. IEEE Trans Biomed Eng 99:1 + + + +
+ + + 36917370 + + 2023 + 03 + 14 + +
+ + 1531-5320 + + + 2023 + Mar + 14 + + + Psychonomic bulletin & review + Psychon Bull Rev + + Evidence or Confidence: What Is Really Monitored during a Decision? + 10.3758/s13423-023-02255-9 + + Assessing our confidence in the choices we make is important to making adaptive decisions, and it is thus no surprise that we excel in this ability. However, standard models of decision-making, such as the drift-diffusion model (DDM), treat confidence assessment as a post hoc or parallel process that does not directly influence the choice, which depends only on accumulated evidence. Here, we pursue the alternative hypothesis that what is monitored during a decision is an evolving sense of confidence (that the to-be-selected option is the best) rather than raw evidence. Monitoring confidence has the appealing consequence that the decision threshold corresponds to a desired level of confidence for the choice, and that confidence improvements can be traded off against the resources required to secure them. We show that most previous findings on perceptual and value-based decisions traditionally interpreted from an evidence-accumulation perspective can be explained more parsimoniously from our novel confidence-driven perspective. Furthermore, we show that our novel confidence-driven DDM (cDDM) naturally generalizes to decisions involving any number of alternative options - which is notoriously not the case with traditional DDM or related models. Finally, we discuss future empirical evidence that could be useful in adjudicating between these alternatives. + © 2023. The Author(s). + + + + Lee + Douglas G + DG + http://orcid.org/0000-0001-5892-8694 + + Institute of Cognitive Sciences and Technologies, National Research Council, Rome, Italy. DouglasGLee@gmail.com. + + + School of Psychological Sciences, Tel Aviv University, Tel Aviv, Israel. DouglasGLee@gmail.com. + + + + Daunizeau + Jean + J + + Paris Brain Institute (ICM), Paris, France. + + + Translational Neuromodeling Unit (TNU), ETH, Zurich, Switzerland. + + + + Pezzulo + Giovanni + G + + Institute of Cognitive Sciences and Technologies, National Research Council, Rome, Italy. + + + + eng + + Journal Article + Review + + + 2023 + 03 + 14 + +
+ + United States + Psychon Bull Rev + 9502924 + 1069-9384 + + IM + + Choice + Metacognition + Preferential decision-making + Value-based decision-making + +
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+ + + 36917372 + + 2023 + 03 + 14 + +
+ + 2191-1991 + + 13 + 1 + + 2023 + Mar + 14 + + + Health economics review + Health Econ Rev + + The level of countries' preparedness to health risks during Covid-19 and pre-pandemic: the differential response to health systems building blocks and socioeconomic indicators. + + 16 + + 10.1186/s13561-023-00428-9 + + The global health security (GHS) Index assesses countries' level of preparedness to health risks. However, there is no evidence on how and whether the effects of health systems building blocks and socioeconomic indicators on the level of preparedness differ for low and high prepared countries. The aim of this study was to examine the contributions of health systems building blocks and socioeconomic indicators to show differences in the level of preparedness to health risks. The study also aimed to examine trends in the level of preparedness and the World Health Organization (WHO) regional differences before and during the Covid-19 pandemic. We used the 2021 GHS index report data and employed quantile regression, log-linear, double-logarithmic, and time-fixed effects models. As robustness checks, these functional form specifications corroborated with one another, and interval validity tests confirmed. The results show that increases in effective governance, supply chain capacity in terms of medicines and technologies, and health financing had positive effects on countries' level of preparedness to health risks. These effects were considerably larger for countries with higher levels of preparedness to health risks. The positive gradient trends signaled a sense of capacity on the part of countries with higher global health security. However, the health workforce including doctors, and health services including hospital beds, were not statistically significant in explaining variations in countries' level of preparedness. While economic factors had positive effects on the level of preparedness to health risks, their impacts across the distribution of countries' level of preparedness to health risks were mixed. The effects of Social Development Goals (SDGs) were greater for countries with higher levels of preparedness to health risks. The effect of the Human Development Index (HDI) was greatest for countries whose overall GHS index lies at the midpoint of the distribution of countries' level of preparedness. High-income levels were associated with a negative effect on the level of preparedness, especially if countries were in the lower quantiles across the distributions of preparedness. Relative to poor countries, middle- and high-income groups had lower levels of preparedness to health risks, an indication of a sense of complacency. We find the pandemic period (year 2021) was associated with a decrease in the level of preparedness to health risks in comparison to the pre-pandemic period. There were significant WHO regional differences. Apart from the Eastern Mediterranean, the rest of the regions were more prepared to health risks compared to Africa. There was a negative trend in the level of preparedness to health risks from 2019 to 2021 although regional differences in changes over time were not statistically significant. In conclusion, attempts to strengthen countries' level of preparedness to health shocks should be more focused on enhancing essentials such as supply chain capacity in terms of medicines and technologies; health financing, and communication infrastructure. Countries should also strengthen their already existing health workforce and health services. Together, strengthening these health systems essentials will be beneficial to less prepared countries where their impact we find to be weaker. Similarly, boosting SDGs, particularly health-related sub-scales, will be helpful to less prepared countries. Moreover, there is a need to curb complacency in preparedness to health risks during pandemics by high-income countries. The negative trend in the level of preparedness to health risks would suggest that there is a need for better preparedness during pandemics by conflating national health with global health risks. This will ensure the imperative of having a synergistic response to global health risks, which is understood by and communicated to all countries and regions. + © 2023. The Author(s). + + + + Da'ar + Omar B + OB + http://orcid.org/0000-0002-2153-8761 + + Department of Health Systems Management, College of Public Health and Health Informatics, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. obdaar@gmail.com. + + + King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. obdaar@gmail.com. + + + Institute for Cost Analysis and Research Evaluation, Minneapolis, MN, USA. obdaar@gmail.com. + + + + Kalmey + Farah + F + + Institute for Cost Analysis and Research Evaluation, Minneapolis, MN, USA. + + + College of Science and Health Professions, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. + + + Organizational Health and Wellbeing at the Division of Health Research, Lancaster University, Lancaster, UK. + + + + eng + + + NRC22/063/01 + King Abdullah International Medical Research Center + + + + + Journal Article + + + 2023 + 03 + 14 + +
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+ + 1531-5320 + + + 2023 + Mar + 14 + + + Psychonomic bulletin & review + Psychon Bull Rev + + Deceitful Hints: a Meta-Analytic Review of the Part-List Cuing Impairment in Recall. + 10.3758/s13423-023-02263-9 + + A large body of research in the study of memory has accumulated to date on the part-list cuing impairment in recall. This phenomenon refers to the lower recall of studied information in the presence of some studied words provided as retrieval cues compared to when no cues are provided. We review the current literature on the part-list cuing impairment in recall and report a meta-analysis utilizing the procedural and statistical information obtained from 109 samples (N = 5,605). In each experiment, participants studied a list of words and subsequently performed a recall task either in the presence or absence of part-list cues. The meta-analysis shows that the part-list cuing impairment is a robust, medium-sized impairment (Cohen, 1988). This recall impairment was not significantly sensitive to the number of study items provided, the relationship among study items, the number of part-list cues provided, the amount of time provided for recall, or certain other factors of interest. Our analyses also demonstrate that longer retention periods between study and retrieval mitigate the part-list cuing impairment in recall. We discuss the implications of meta-analysis results for elements of experimental design, the findings of past literature, as well as the underlying theoretical mechanisms proposed to account for this impairment in recall and the applied consequences of this recall impairment. + © 2023. The Psychonomic Society, Inc. + + + + Pepe + Nicholas W + NW + http://orcid.org/0000-0003-0465-3319 + + Department of Psychology, Stony Brook University, Stony Brook, NY, 11794-2500, USA. nicholas.w.pepe@stonybrook.edu. + + + + Moyer + Anne + A + + Department of Psychology, Stony Brook University, Stony Brook, NY, 11794-2500, USA. + + + + Peña + Tori + T + + Department of Psychology, Stony Brook University, Stony Brook, NY, 11794-2500, USA. + + + + Rajaram + Suparna + S + + Department of Psychology, Stony Brook University, Stony Brook, NY, 11794-2500, USA. + + + + eng + + Journal Article + Review + + + 2023 + 03 + 14 + +
+ + United States + Psychon Bull Rev + 9502924 + 1069-9384 + + IM + + Memory impairment + Meta-analysis + Part-list cues + Recall + +
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+ + 1614-7499 + + + 2023 + Mar + 14 + + + Environmental science and pollution research international + Environ Sci Pollut Res Int + + Climatic envelopes of the genus Lacerta Linnaeus, 1758 in Türkiye: an application of ecological niche modeling. + 10.1007/s11356-023-26351-4 + + Six species belonging to the genus Lacerta live in Türkiye. In this study, both present and future potential distribution maps were created based on occurrence data and climatic variables for these six species. Two scenarios for future projections (shared socioeconomic pathways, SSPs,: 245 and 585) and two timeframes (2041-2060 and 2081-2100) were used. The present and future potential distributions of these species were compared. As a result, it was predicted that the distribution ranges in the six species will expand in the future, and this expansion has revealed new environments. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Gül + Serkan + S + http://orcid.org/0000-0002-0372-7462 + + Department of Biology, Faculty of Arts and Sciences, Recep Tayyip Erdoğan University, 53100, Rize, Türkiye. serkan.gul@erdogan.edu.tr. + + + + Kumlutaş + Yusuf + Y + + Department of Biology, Faculty of Science, Dokuz Eylül University, Buca, İzmir, 35390, Türkiye. + + + Fauna and Flora Research and Application Center, Dokuz Eylül University, Buca, İzmir, 35390, Türkiye. + + + + Ilgaz + Çetin + Ç + + Department of Biology, Faculty of Science, Dokuz Eylül University, Buca, İzmir, 35390, Türkiye. + + + Fauna and Flora Research and Application Center, Dokuz Eylül University, Buca, İzmir, 35390, Türkiye. + + + + Candan + Kamil + K + + Department of Biology, Faculty of Science, Dokuz Eylül University, Buca, İzmir, 35390, Türkiye. + + + Fauna and Flora Research and Application Center, Dokuz Eylül University, Buca, İzmir, 35390, Türkiye. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
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+ + + 36917375 + + 2023 + 03 + 14 + +
+ + 1614-7499 + + + 2023 + Mar + 14 + + + Environmental science and pollution research international + Environ Sci Pollut Res Int + + Do changes in Lactuca sativa metabolic performance, induced by mycorrhizal symbionts and leaf UV-B irradiation, play a role towards tolerance to a polyphagous insect pest? + 10.1007/s11356-023-26218-8 + + The increased ultraviolet radiation (UV) due to the altered stratospheric ozone leads to multiple plant physiological and biochemical adaptations, likely affecting their interaction with other organisms, such as pests and pathogens. Arbuscular mycorrhizal fungi (AMF) and UV-B treatment can be used as eco-friendly techniques to protect crops from pests by activating plant mechanisms of resistance. In this study, we investigated plant (Lactuca sativa) response to UV-B exposure and Funneliformis mosseae (IMA1) inoculation as well as the role of a major insect pest, Spodoptera littoralis. Lettuce plants exposed to UV-B were heavier and taller than non-irradiated ones. A considerable enrichment in phenolic, flavonoid, anthocyanin, and carotenoid contents and antioxidant capacity, along with redder and more homogenous leaf color, were also observed in UV-B-treated but not in AMF-inoculated plants. Biometric and biochemical data did not differ between AMF and non-AMF plants. AMF-inoculated plants showed hyphae, arbuscules, vesicles, and spores in their roots. AMF colonization levels were not affected by UV-B irradiation. No changes in S. littoralis-feeding behavior towards treated and untreated plants were observed, suggesting the ability of this generalist herbivore to overcome the plant chemical defenses boosted by UV-B exposure. The results of this multi-factorial study shed light on how polyphagous insect pests can cope with multiple plant physiological and biochemical adaptations following biotic and abiotic preconditioning. + © 2023. The Author(s). + + + + Santin + Marco + M + + Department of Agriculture, Food and Environment, University of Pisa, Via del Borghetto 80, 56124, Pisa, Italy. + + + + Zeni + Valeria + V + + Department of Agriculture, Food and Environment, University of Pisa, Via del Borghetto 80, 56124, Pisa, Italy. + + + + Grassi + Arianna + A + + Department of Agriculture, Food and Environment, University of Pisa, Via del Borghetto 80, 56124, Pisa, Italy. + + + + Ricciardi + Renato + R + + Department of Agriculture, Food and Environment, University of Pisa, Via del Borghetto 80, 56124, Pisa, Italy. + + + + Pieracci + Ylenia + Y + + Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy. + + + + Di Giovanni + Filippo + F + + Department of Life Sciences, University of Siena, Via Aldo Moro 2, Siena, Italy. + + + + Panzani + Sofia + S + + Department of Agriculture, Food and Environment, University of Pisa, Via del Borghetto 80, 56124, Pisa, Italy. + + + + Frasconi + Christian + C + + Department of Agriculture, Food and Environment, University of Pisa, Via del Borghetto 80, 56124, Pisa, Italy. + + + + Agnolucci + Monica + M + + Department of Agriculture, Food and Environment, University of Pisa, Via del Borghetto 80, 56124, Pisa, Italy. + + + Interdepartmental Research Center Nutrafood-Nutraceuticals and Food for Health, University of Pisa, 56124, Pisa, Italy. + + + + Avio + Luciano + L + + Department of Agriculture, Food and Environment, University of Pisa, Via del Borghetto 80, 56124, Pisa, Italy. + + + Interdepartmental Research Center Nutrafood-Nutraceuticals and Food for Health, University of Pisa, 56124, Pisa, Italy. + + + + Turrini + Alessandra + A + + Department of Agriculture, Food and Environment, University of Pisa, Via del Borghetto 80, 56124, Pisa, Italy. + + + Interdepartmental Research Center Nutrafood-Nutraceuticals and Food for Health, University of Pisa, 56124, Pisa, Italy. + + + + Giovannetti + Manuela + M + + Department of Agriculture, Food and Environment, University of Pisa, Via del Borghetto 80, 56124, Pisa, Italy. + + + Interdepartmental Research Center Nutrafood-Nutraceuticals and Food for Health, University of Pisa, 56124, Pisa, Italy. + + + + Ruffini Castiglione + Monica + M + + Interdepartmental Research Center Nutrafood-Nutraceuticals and Food for Health, University of Pisa, 56124, Pisa, Italy. + + + Department of Biology, University of Pisa, Via L. Ghini 13, 56126, Pisa, Italy. + + + + Ranieri + Annamaria + A + + Department of Agriculture, Food and Environment, University of Pisa, Via del Borghetto 80, 56124, Pisa, Italy. + + + Interdepartmental Research Center Nutrafood-Nutraceuticals and Food for Health, University of Pisa, 56124, Pisa, Italy. + + + + Canale + Angelo + A + + Department of Agriculture, Food and Environment, University of Pisa, Via del Borghetto 80, 56124, Pisa, Italy. + + + Interdepartmental Research Center Nutrafood-Nutraceuticals and Food for Health, University of Pisa, 56124, Pisa, Italy. + + + + Lucchi + Andrea + A + + Department of Agriculture, Food and Environment, University of Pisa, Via del Borghetto 80, 56124, Pisa, Italy. + + + Interdepartmental Research Center Nutrafood-Nutraceuticals and Food for Health, University of Pisa, 56124, Pisa, Italy. + + + + Agathokleous + Evgenios + E + + Department of Ecology, School of Applied Meteorology, Science & Technology (NUIST), Nanjing University of Information, Nanjing, 210044, China. + + + + Benelli + Giovanni + G + http://orcid.org/0000-0001-8971-6010 + + Department of Agriculture, Food and Environment, University of Pisa, Via del Borghetto 80, 56124, Pisa, Italy. giovanni.benelli@unipi.it. + + + + eng + + + PRA_2020_19 + Università di Pisa + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Environ Sci Pollut Res Int + 9441769 + 0944-1344 + + IM + + Anthropogenic change + Chemical ecology + Feeding behavior + Noctuidae + Plant nutraceutical + Plant–insect tolerance + Priming + Spodoptera littoralis + +
+ + + + 2022 + 11 + 22 + + + 2023 + 02 + 26 + + + 2023 + 3 + 14 + 12 + 20 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917375 + 10.1007/s11356-023-26218-8 + 10.1007/s11356-023-26218-8 + + + References + + Agathokleous E (2021) The rise and fall of photosynthesis: hormetic dose response in plants. J for Res 32:789–803. https://doi.org/10.1007/s11676-020-01252-1 + + 10.1007/s11676-020-01252-1 + + + + Agathokleous E, Sakikawa T, Abu ElEla SA, Mochizuki T, Nakamura M, Watanabe M, Kawamura K, Koike T (2017) Ozone alters the feeding behavior of the leaf beetle Agelastica coerulea (Coleoptera: Chrysomelidae) into leaves of Japanese white birch (Betula platyphylla var. japonica). 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+ + 1614-7499 + + + 2023 + Mar + 14 + + + Environmental science and pollution research international + Environ Sci Pollut Res Int + + Clues about wood density and trace-element variability of Schizolobium parahyba var. amazonicum (Huber ex Ducke) Barneby for bioenergy use. + 10.1007/s11356-023-26343-4 + + The interest of biofuel producers in Neotropical species that have high growth rates, slight wood density variability, and elemental composition that does not compromise the environment has increased in recent decades. We investigated the density and chemical characteristics of wood of Schizolobium parahyba var. amazonicum (Huber × Ducke) Barneby as a source for the generation of bioenergy. Apparent radial wood density profiles (X-ray densitometry (XRD)) and the elemental distribution (X-ray fluorescence (XRF)) of Cl, S, K, and Ca in the wood of nine S. parahyba var. amazonicum trees, divided into three diameter classes (I = 15.5, II = 19.5, and III = 23.5 cm) were analyzed. The high heating value (HHV) of the wood samples was determined, and the energy density was estimated by the product of the HHV and the apparent density. Trees that grew better (classes II and III) produced wood with higher density. These trees showed higher concentrations of K and S, and lower concentrations of Ca and Cl. The highest Cl concentrations were observed in classes with smaller diameters. The chlorine levels met the standards for use of this wood as fuel, but the sulfur levels were higher than the threshold recommended by the ISO 17225-3:2021 guidelines, which can limit the use of the species for certain energy uses. The wood of S. parahyba var. amazonicum had interesting characteristics for the production of bioenergy due to its low density, so it can be used in the production of solid biofuels such as pellets and briquettes. Monitoring chlorine and sulfur is important, since during the combustion of biomass they are released into the atmosphere and can negatively contribute to the effects of climate change. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Ucella-Filho + João Gilberto Meza + JGM + + Departamento de Ciências Florestais e da Madeira, Universidade Federal do Espírito Santo (UFES). Av. Governador Lindemberg, Jerônimo Monteiro, ES, 31629550-000, Brazil. + + + + Dias Júnior + Ananias Francisco + AF + + Departamento de Ciências Florestais e da Madeira, Universidade Federal do Espírito Santo (UFES). Av. Governador Lindemberg, Jerônimo Monteiro, ES, 31629550-000, Brazil. + + + + de Souza + Elias Costa + EC + http://orcid.org/0000-0001-9514-635X + + Departamento de Ciências Florestais, Universidade de São Paulo (USP), Escola Superior de Agricultura Luiz de Queiroz, Av. Pádua Dias N° 11, Piracicaba, São Paulo, 13418-900, Brazil. eliasrem@usp.br. + + + Departmento de Tecnologia e Recursos Naturais (DTRN), Universidade do Estado do Pará (UEPA), Campus VI, Rodovia PA-125, Angelim, Paragominas, 68625-000, Brazil. eliasrem@usp.br. + + + + da Silva + João Gabriel Missia + JGM + + Departamento de Ciências Florestais e da Madeira, Universidade Federal do Espírito Santo (UFES). Av. Governador Lindemberg, Jerônimo Monteiro, ES, 31629550-000, Brazil. + + + + Sant'anna Neto + Analder + A + + Departamento de Ciências Florestais, Universidade de São Paulo (USP), Escola Superior de Agricultura Luiz de Queiroz, Av. Pádua Dias N° 11, Piracicaba, São Paulo, 13418-900, Brazil. + + + + da Silva + Ana Paula Câmara + APC + + Departamento de Ciências Florestais e da Madeira, Universidade Federal do Espírito Santo (UFES). Av. Governador Lindemberg, Jerônimo Monteiro, ES, 31629550-000, Brazil. + + + + Santos + Lourdes Maria Hilgert + LMH + + Departamento de Ciências Florestais e da Madeira, Universidade Federal do Espírito Santo (UFES). Av. Governador Lindemberg, Jerônimo Monteiro, ES, 31629550-000, Brazil. + + + + Rodriguez + Daigard Ricardo Ortega + DRO + + Departamento de Ciências Florestais, Universidade de São Paulo (USP), Escola Superior de Agricultura Luiz de Queiroz, Av. Pádua Dias N° 11, Piracicaba, São Paulo, 13418-900, Brazil. + + + DendrOlavide-Dept., Sistemas FísicosQuímicos y Naturales, Universidad Pablo de Olavide, Crta. Utrera Km. 1, 41013, Seville, Spain. + + + + Tomazello-Filho + Mário + M + + Departamento de Ciências Florestais, Universidade de São Paulo (USP), Escola Superior de Agricultura Luiz de Queiroz, Av. Pádua Dias N° 11, Piracicaba, São Paulo, 13418-900, Brazil. + + + + Brito + José Otávio + JO + + Departamento de Ciências Florestais, Universidade de São Paulo (USP), Escola Superior de Agricultura Luiz de Queiroz, Av. Pádua Dias N° 11, Piracicaba, São Paulo, 13418-900, Brazil. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Environ Sci Pollut Res Int + 9441769 + 0944-1344 + + IM + + Biomass energy + Dendrochemistry + Neotropical species + Renewable energy + Solid biomass fuels + X-ray densitometry + X-ray fluorescence + +
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+ + + 36917381 + + 2023 + 03 + 14 + +
+ + 1614-7499 + + + 2023 + Mar + 14 + + + Environmental science and pollution research international + Environ Sci Pollut Res Int + + Modification of fluorescence staining method for small-sized microplastic quantification: Focus on the interference exclusion and exposure time optimization. + 10.1007/s11356-023-26226-8 + + Microplastics are an emerging pollutant of global concern, and fluorescence staining as an efficient method for small-sized microplastic qualification often undergoes the serious interference from external environments. The key steps affecting the accuracy of fluorescent staining and the corresponding quality assurance measures were rarely known. Therefore, this study took the Nile Red/DAPI co-staining method as an example to explore the key factors affecting its accuracy and effective measures to avoid interference. High background microplastic contamination in typical lab waters (up to 1115 MP/L), glass fiber filter membrane and glassware were identified as dominant factors affecting microplastic quantification. The background microplastics in lab waters mainly originated from the process of water production and storage. A simple filtration process removed 99% of the background microplastic in the lab waters. After burning at 500 °C for 1 h, the microplastic contamination in the filter membrane and glassware was completely eliminated. H2O2 pretreatment and exposure time caused erroneous microplastic size assessment, and were suggested to be set at 48 h and 10 ms, respectively. During the extraction process, the residue in beakers reached ~ 20% and > 50% for 5 μm and 20 μm sized microplastics, respectively, greatly contributing to the microplastic loss. The comprehensive modified measures caused microplastic concentrations in the three typical samples detected by Nile Red/DAPI co-staining method to decrease by 65.7 - 92.2% and to approach the micro-Raman results. This study clarified the reasons for interfering with quantitative microplastics by fluorescent staining and the effective measures to avoid interference, which were conducive to improving the accuracy of quantitative methods of microplastics. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Hu + Wentao + W + + School of Civil Engineering, Hefei University of Technology, Hefei, 230009, People's Republic of China. + + + Anhui Provincial Engineering Laboratory for Rural Water Environment and Resources, Hefei University of Technology, Hefei, 230009, People's Republic of China. + + + + Tang + Rui + R + + Shanghai Key Laboratory of Materials Protection and Advanced Materials in Electric Power, Shanghai University of Electric Power, Shanghai, 200090, People's Republic of China. + + + Shanghai Institute of Pollution Control and Ecological Security, Shanghai, 200090, People's Republic of China. + + + + Yuan + Shoujun + S + http://orcid.org/0000-0002-8074-6771 + + School of Civil Engineering, Hefei University of Technology, Hefei, 230009, People's Republic of China. sjyuan@hfut.edu.cn. + + + Anhui Provincial Engineering Laboratory for Rural Water Environment and Resources, Hefei University of Technology, Hefei, 230009, People's Republic of China. sjyuan@hfut.edu.cn. + + + + Gong + Miao + M + + School of Civil Engineering, Hefei University of Technology, Hefei, 230009, People's Republic of China. + + + Anhui Provincial Engineering Laboratory for Rural Water Environment and Resources, Hefei University of Technology, Hefei, 230009, People's Republic of China. + + + + Shi + Penghui + P + + Shanghai Key Laboratory of Materials Protection and Advanced Materials in Electric Power, Shanghai University of Electric Power, Shanghai, 200090, People's Republic of China. + + + Shanghai Institute of Pollution Control and Ecological Security, Shanghai, 200090, People's Republic of China. + + + + Wang + Wei + W + + School of Civil Engineering, Hefei University of Technology, Hefei, 230009, People's Republic of China. + + + Anhui Provincial Engineering Laboratory for Rural Water Environment and Resources, Hefei University of Technology, Hefei, 230009, People's Republic of China. + + + + Hu + Zhen-Hu + ZH + + School of Civil Engineering, Hefei University of Technology, Hefei, 230009, People's Republic of China. + + + Anhui Provincial Engineering Laboratory for Rural Water Environment and Resources, Hefei University of Technology, Hefei, 230009, People's Republic of China. + + + + eng + + + 2019YFC0408502 + the National Key R&D Program of China + + + + PA2021KCPY0029 + the Fundamental Research Funds for the Central Universities of China + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Environ Sci Pollut Res Int + 9441769 + 0944-1344 + + IM + + Background contamination + Fluorescence staining method + Microplastic + Modification + Quantification + +
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Sci Total Environ 822:153603. https://doi.org/10.1016/j.scitotenv.2022.153603 + + 10.1016/j.scitotenv.2022.153603 + + + + Xiang Y, Jiang L, Zhou Y, Luo Z, Zhi D, Yang J, Lam SS (2022) Microplastics and environmental pollutants: Key interaction and toxicology in aquatic and soil environments. J Hazard Mater 422:126843. https://doi.org/10.1016/j.jhazmat.2021.126843 + + 10.1016/j.jhazmat.2021.126843 + + + + Xiong X, Liu Q, Chen X, Wang R, Duan M, Wu C (2021) Occurrence of microplastic in the water of different types of aquaculture ponds in an important lakeside freshwater aquaculture area of China. Chemosphere 282:131126. https://doi.org/10.1016/j.chemosphere.2021.131126 + + 10.1016/j.chemosphere.2021.131126 + + + + Xu J-L, Thomas KV, Luo Z, Gowen AA (2019) FTIR and Raman imaging for microplastics analysis: State of the art, challenges and prospects. TrAC, Trends Anal Chem 119:115629. https://doi.org/10.1016/j.trac.2019.115629 + + 10.1016/j.trac.2019.115629 + + + + Zhu D, Ma J, Li G, Rillig MC, Zhu Y-G (2022) Soil plastispheres as hotpots of antibiotic resistance genes and potential pathogens. ISME J 16:521–532. https://doi.org/10.1038/s41396-021-01103-9 + + 10.1038/s41396-021-01103-9 + + + + +
+ + + 36917380 + + 2023 + 03 + 14 + +
+ + 1614-7499 + + + 2023 + Mar + 14 + + + Environmental science and pollution research international + Environ Sci Pollut Res Int + + Community kitchen tandoors (CKT)-a potential candidate for air pollution mitigation strategies? + 10.1007/s11356-023-26176-1 + + Community kitchen tandoor (CKT) is a clay-based hollow cylindrical device commonly used in South Asian and Middle Eastern countries for baking flatbreads and cooking meat. These CKTs, generally fuelled by charcoal or wood, contribute significantly to the pollution loads in ambient air along with occupational exposure hazards. CKTs, being a part of the informal sector, lack emissions and safety guidelines. This study surveys 139 restaurants in CKT hotspots of New Delhi, India, to understand tandoor design and operational parameters and to assess PM2.5 and CO exposure concentrations at representative field restaurants. PM2.5 and CO exposure concentrations from traditional CKT was found to be several-folds higher than safe indoor air quality levels. Further, the traditional CKT was evaluated for different improved fuels (like briquettes and pellets) in the laboratory for PM2.5 and CO microenvironment concentrations. It was found that the fuel improvements in traditional CKT could not improve microenvironment concentrations to the desired levels; hence, an automated pellet-fed forced-draft improved tandoor with an improved combustion chamber design is demonstrated. The results of the laboratory trial of improved tandoor were compared with traditional tandoor (using pellets) and have shown 84% and 94% reductions in PM2.5 and CO concentrations, respectively, indicating significant benefits to the environment and health. We recommend implementing such improved CKT, on a large scale, combined with other identified control options, as a potential candidate under air pollution mitigation strategies in cities' action plans under National Clean Air Programme (NCAP). + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Naved + Mohd Mubashshir + MM + + CSIR-National Environmental Engineering Research Institute (CSIR-NEERI), Nehru Marg, Nagpur, 440020, Maharashtra, India. + + + Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, 201002, India. + + + + Wathore + Roshan + R + + CSIR-National Environmental Engineering Research Institute (CSIR-NEERI), Nehru Marg, Nagpur, 440020, Maharashtra, India. + + + Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, 201002, India. + + + + Kumbhare + Himanshu + H + + CSIR-National Environmental Engineering Research Institute (CSIR-NEERI), Nehru Marg, Nagpur, 440020, Maharashtra, India. + + + + Gupta + Ankit + A + http://orcid.org/0000-0001-6658-3008 + + Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, 201002, India. a1_gupta@neeri.res.in. + + + CSIR-National Environmental Engineering Research Institute, Delhi Zonal Centre, Naraina, New Delhi, 110028, India. a1_gupta@neeri.res.in. + + + + Labhasetwar + Nitin + N + + CSIR-National Environmental Engineering Research Institute (CSIR-NEERI), Nehru Marg, Nagpur, 440020, Maharashtra, India. + + + Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, 201002, India. + + + + eng + + + GAP-02-2265 + DPCC + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Environ Sci Pollut Res Int + 9441769 + 0944-1344 + + IM + + Ambient air pollution + Household air pollution + Improved tandoor + Occupational hazard + Pollutant exposure + Traditional tandoor + +
+ + + + 2022 + 03 + 04 + + + 2023 + 02 + 23 + + + 2023 + 3 + 14 + 12 + 20 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917380 + 10.1007/s11356-023-26176-1 + 10.1007/s11356-023-26176-1 + + + + Adkins E, Chen J, Winiecki J et al (2010) Energy for sustainable development testing institutional biomass cookstoves in rural Kenyan schools for the Millennium Villages Project. Energy Sustain Dev 14:186–193. https://doi.org/10.1016/j.esd.2010.07.002 + + 10.1016/j.esd.2010.07.002 + + + + Akçay MN, Öztürk G, Aydinli B, Özoǧul B (2008) Tandir burns: a severe cause of burns in rural Turkey. Burns 34:268–270. https://doi.org/10.1016/j.burns.2007.03.007 + + 10.1016/j.burns.2007.03.007 + + + + Alam Shah MA, Inayat Q, Ali M et al (2021) Correlation between occupation and sperm morphology along with sperm count in industrial workers. 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J Dev Stud 56:1309–1329. https://doi.org/10.1080/00220388.2019.1657571 + + 10.1080/00220388.2019.1657571 + + + + Gul, A., Goker, H., Senol Sabanci, A.K. and Turkyilmaz K (2014) Relationship between pinguecula formation and exposure to tandoor ovens in a hospital-based study + + + Gulia S, Shrivastava A, Nema AK, Khare M (2015) Assessment of urban air quality around a heritage site using AERMOD: a case study of Amritsar City, India. Environ Model Assess 20:599–608. https://doi.org/10.1007/s10666-015-9446-6 + + 10.1007/s10666-015-9446-6 + + + + Gupta A, Mulukutla ANV, Gautam S et al (2020) Development of a practical evaluation approach of a typical biomass cookstove. 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Int J Environ Res Public Health 12:1773–1787. https://doi.org/10.3390/ijerph120201773 + + 10.3390/ijerph120201773 + + + + Nabeel I, Alamgir H (2018) Restaurant inspection reports as a proxy measure for occupational health and safety: South Asian restaurant workers in New York City. Ann Glob Heal 84:495–499. https://doi.org/10.29024/aogh.2332 + + + Naved MM, Kumbhare H, Wathore R et al (2022) Evidence for reduced performance discrepancy of improved cookstoves at laboratory and field. Air Qual Atmos Health. https://doi.org/10.1007/s11869-022-01158-3 + + 10.1007/s11869-022-01158-3 + + + + Nwaokocha CN, Giwa SO (2016) Investigation of bio-waste as alternative fuel for cooking. 3rd International Conference On African Development Issues (CU-ICADI), Covenant University, Ota, Nigeria, pp.1–5 Retrieved from https://core.ac.uk/download/pdf/43010105.pdf + + + Ojolo SJ, Abolarin SM, Adegbenro O (2012) Development of a laboratory scale updraft gasifier. 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Mitig Adapt Strateg Glob Chang 14:627–633. https://doi.org/10.1007/s11027-009-9187-4 + + 10.1007/s11027-009-9187-4 + + + + Perincek G, Avci S (2019) Tandoor smoke exposure in female astmatic patients: a cross-sectional study from eastern of Turkey. Turkish Thorac J 20:32. https://doi.org/10.5152/TurkThoracJ.2019.32 + + 10.5152/TurkThoracJ.2019.32 + + + + Rajak R, Chattopadhyay A (2019) Short and long-term exposure to ambient air pollution and impact on health in India: a systematic review. Int J Environ Health Res 1–25. https://doi.org/10.1080/09603123.2019.1612042 + + + Raman P, Ram NK, Gupta R (2014) Development, design and performance analysis of a forced draft clean combustion cookstove powered by a thermo electric generator with multi-utility options. 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Energies 14:6910. https://doi.org/10.3390/en14216910 + + + Santoso M, Lestiani DD, Mukhtar R et al (2011) Preliminary study of the sources of ambient air pollution in Serpong, Indonesia. Atmos Pollut Res 2:190–196. https://doi.org/10.5094/APR.2011.024 + + 10.5094/APR.2011.024 + + + + Sharma MMK (2021) Exploitation And bad working conditions of employees in small hotels in tourist City Ajmer: Reality or rumer? Journal of Social Responsibility, Tourism and Hospitality (JSRTH) ISSN 2799-1016 1:24–34. https://doi.org/10.55529/jsrth.11.24.34 + + + Sharma M, Dikshit O (2016) Comprehensive study on air pollution and green house gases (GHGs) in Delhi. A report submitted to Government of NCT Delhi and DPCC Delhi. Retrieved from http://environment.delhigovt.nic.in/wps/wcm/connect/735190804acf830c8eec8f09c683c810/Final+Report09Jan2016.pdf?MOD=AJPERES + + + Sharma S, Bawase MA, Ghosh P, et al (2018) Source apportionment of PM2. 5 and PM10 of Delhi NCR for identification of major sources. Energy Resour Institute, Delhi Autom Res Assoc India + + + Sharma D, Jain S (2019) Impact of intervention of biomass cookstove technologies and kitchen characteristics on indoor air quality and human exposure in rural settings of India. Environ Int 123:240–255. https://doi.org/10.1016/j.envint.2018.11.059 + + 10.1016/j.envint.2018.11.059 + + + + Sharma SK, Mandal TK (2017) Chemical composition of fine mode particulate matter (PM 2.5) in an urban area of Delhi, India and its source apportionment. Urban Clim 21:106–122. https://doi.org/10.1016/j.uclim.2017.05.009 + + 10.1016/j.uclim.2017.05.009 + + + + Singh P (2019) Delhi: Corporations act against 500 eateries with tandoors. The Times of India. Retrieved from https://timesofindia.indiatimes.com/city/delhi/delhicorporations-act-against-500-eateries-withtandoors/articleshow/71845177.cms + + + Smith KR, Sagar A (2014) Making the clean available: escaping India’s Chulha Trap. 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Environ Pollut 272:115558. https://doi.org/10.1016/j.envpol.2020.115558 + + 10.1016/j.envpol.2020.115558 + + + + +
+ + + 36917376 + + 2023 + 03 + 14 + +
+ + 1614-7499 + + + 2023 + Mar + 14 + + + Environmental science and pollution research international + Environ Sci Pollut Res Int + + Investigating the nexus between information technology capabilities, knowledge management, and green product innovation: evidence from SME industry. + 10.1007/s11356-023-26308-7 + + The aim of this study to investigate the relationship between information technology capabilities (ITCs) and green product innovation (GPI). The information technology (IT) capabilities with multiple dimensions, such as IT competence, IT integration, and IT infrastructure, were used in this paper. Moreover, to verify the deep relationship between ITCs and GPI, we used knowledge management (KM) as a mediator. The data were collected through a questionnaire from the senior managers, middle-level managers, and operational staff associated with the small- and medium-sized production industry of Pakistan. We collect data in two waves between January 2022 and July 2022. The data were analyzed through the partial least square structural equation modeling through SmartPLS 3.2.2. The findings of this study conclude. First, in the direct relationship, two IT capabilities, such as IT competence and IT infrastructure, have a positive and significant direct relationship with green product innovation, but IT integration has an insignificant relationship with green product innovation. Second, the results show that three IT capabilities have positively influenced knowledge management. Third, the results confirm that KM has a significant positive effect on GPI. Finally, the outcomes confirmed that knowledge management positively and significantly mediates between all IT capabilities and GPI in the indirect relationship. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Rasool + Samma Faiz + SF + + College of Business Administration, Al Yamamah University, Riyadh, Kingdom of Saudi Arabia. + + + Department of Management, Faculty of Informatics and Management, University of Hradec Králové, 50003, Hradec Králové, Czech Republic. + + + + Samma + Madeeha + M + http://orcid.org/0000-0002-9792-3279 + + School of Management, Shanghai University, Shanghai, 200444, China. madeeha@i.shu.edu.cn. + + + + Mohelska + Hana + H + + Faculty of Informatics and Management, University of Hradec Králové, 50003, Hradec Králové, Czech Republic. + + + + Rehman + Fazal Ur + FU + + Science and Research Center, Faculty of Economic and Administration, University of Pardubice, Pardubice, 53210, Czech Republic. + + + + eng + + + CZ.02.2.69/0.0/0.O/18_O53/0017841 + The International Mobilities for Research Activities at the University of Hradec Králové, Czech Republic + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Environ Sci Pollut Res Int + 9441769 + 0944-1344 + + IM + + Green product innovation + Information technology capabilities + Knowledge management + Technological competence + Technological infrastructure + +
+ + + + 2022 + 12 + 17 + + + 2023 + 03 + 02 + + + 2023 + 3 + 14 + 12 + 20 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917376 + 10.1007/s11356-023-26308-7 + 10.1007/s11356-023-26308-7 + + + + Abbas J, Sağsan M (2019) Impact of knowledge management practices on green innovation and corporate sustainable development: a structural analysis. J Clean Prod 229:611–620 + + 10.1016/j.jclepro.2019.05.024 + + + + Abbas S, Gui P, Chen A, Ali N (2022) The effect of renewable energy development, market regulation, and environmental innovation on CO2 emissions in BRICS countries. Environ Sci Pollut Res 29(39):59483–59501 + + 10.1007/s11356-022-20013-7 + + + + Abdelqader M, Abu Q, Al Sakarneh B (2013) Impact of knowledge management and innovation on performance. 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+ + + 36917387 + + 2023 + 03 + 14 + +
+ + 1614-7499 + + + 2023 + Mar + 14 + + + Environmental science and pollution research international + Environ Sci Pollut Res Int + + Br vacancy engineering in Cs3Bi2Br9 for photocatalytic NO oxidation under visible light. + 10.1007/s11356-023-25993-8 + + Photocatalysis using the visible light of the sun is an environmentally friendly method of eliminating the NOx pollutant from the ambient air. Although Cs3Bi2Br9, a semiconductor with a band gap of 2.54 eV, may be a strong absorber of visible light, its photocatalysis towards the abatement of NOx is unknown. In this study, Cs3Bi2-xPbxBr9-x (0 ≤ x ≤ 0.0789) are used for the photocatalytic oxidation of NOx. A significant NO oxidation efficiency (80%) is observed over Cs3Bi2-xPbxBr9-x (x = 0.0443) under visible light, which is attributable to the Br vacancy (VBr) brought about by Pb2+ doping. The presence of VBr increased the ionic selectivity of in the oxidized NO. At higher Pb doping level, two HONOs adsorbed on the VBr, linked, and then reduced by hot electrons to produce N2O22-. The di-azo coupling could passivate the activation of NO on the VBr. This work advances the defect engineering of halide for the photo-driving solid-gas reaction in air. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Chen + Jingwen + J + + College of Resources and Environment, Southwest University, Chongqing, 400715, China. + + + + Wu + Menglin + M + + College of Resources and Environment, Southwest University, Chongqing, 400715, China. + + + + Ni + Jiupai + J + + College of Resources and Environment, Southwest University, Chongqing, 400715, China. + + + National Base of International S&T Collaboration On Water Environmental Monitoring and Simulation in Three Gorges Reservoir Region, Chongqing, 400716, China. + + + + Ni + Chengsheng + C + http://orcid.org/0000-0002-7184-1654 + + College of Resources and Environment, Southwest University, Chongqing, 400715, China. nichengsheg@swu.edu.cn. + + + National Base of International S&T Collaboration On Water Environmental Monitoring and Simulation in Three Gorges Reservoir Region, Chongqing, 400716, China. nichengsheg@swu.edu.cn. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Environ Sci Pollut Res Int + 9441769 + 0944-1344 + + IM + + Bismuth halide + Br vacancies + Environment remediation + NO oxidation + Photocatalysis + +
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Chem Mater 34(1):297–306 + + 10.1021/acs.chemmater.1c03540 + + + + Ni C, Hedley G, Payne J, Svrcek V, McDonald C, Jagadamma LK, Edwards P, Martin R, Jain G, Carolan D, Mariotti D, Maguire P, Samuel I, Irvine J (2017) Charge carrier localised in zero-dimensional (Ch3nh3)3bi2i9 clusters. Nat Commun 8(1):1–7 + + 10.1038/s41467-017-00261-9 + + + + Nie J, Zhu G, Zhang W, Gao J, Zhong P, Xie X, Huang Y, Hojamberdiev M (2021) Oxygen vacancy defects-boosted deep oxidation of No by Β-Bi2o3/Ceo2-Δ P-N heterojunction photocatalyst in situ synthesized from Bi/Ce(Co3)(Oh) precursor. Chem Eng J 424:130327 + + 10.1016/j.cej.2021.130327 + + + + Pistor P, Meyns M, Guc M, Wang H-C, Marques MAL, Alcobé X, Cabot A, Izquierdo-Roca V (2020) Advanced Raman spectroscopy of Cs2agbibr6 double perovskites and identification of Cs3bi2br9 secondary phases. Scripta Mater 184:24–29 + + 10.1016/j.scriptamat.2020.03.040 + + + + Prati MV, Costagliola MA, Zuccheroso A, Napolitano P (2019) Assessment of euro 5 diesel vehicle Nox emissions by laboratory and track testing. Environ Sci Pollut Res Int 26(11):10576–10586 + + 10.1007/s11356-019-04486-7 + + + + Roy M, Ghorui S, Bhawna, Kangsabanik J, Yadav R, Alam A, Aslam M (2020) Enhanced visible light absorption in layered Cs3bi2br9 halide perovskites: heterovalent Pb2+ substitution-induced defect band formation. J Phys Chem C 124(36):19484–19491 + + 10.1021/acs.jpcc.0c05880 + + + + Samanta D, Saha P, Ghosh B, Chaudhary SP, Bhattacharyya S, Chatterjee S, Mukherjee GD (2021) Pressure-induced emergence of visible luminescence in lead free halide perovskite Cs3bi2br9: effect of structural distortion. J Phys Chem C 125(6):3432–3440 + + 10.1021/acs.jpcc.0c10624 + + + + Sheng J, He Y, Li J, Yuan C, Huang H, Wang S, Sun Y, Wang Z, Dong F (2020) Identification of halogen-associated active sites on bismuth-based perovskite quantum dots for efficient and selective Co2-to-Co photoreduction. ACS Nano 14(10):13103–13114 + + 10.1021/acsnano.0c04659 + + + + Steirer KX, Schulz P, Teeter G, Stevanovic V, Yang M, Zhu K, Berry JJ (2016) Defect tolerance in methylammonium lead triiodide perovskite. ACS Energy Lett 1(2):360–366 + + 10.1021/acsenergylett.6b00196 + + + + Tailor NK, Satapathi S (2020) Structural disorder and spin dynamics study in millimeter-sized all-inorganic lead-free cesium bismuth halide perovskite single crystals. ACS Appl Energ Mater 3(12):11732–11740 + + 10.1021/acsaem.0c01849 + + + + Tang C, Cheng M, Lai C, Li L, Yang X, Du L, Zhang G, Wang G, Yang L (2023) Recent progress in the applications of non-metal modified graphitic carbon nitride in photocatalysis. 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Chem Eng J (lausanne) 452:139662 + + 10.1016/j.cej.2022.139662 + + + + Yang JL, Wang XD, Wang H, Dong F, Zhu MS (2021) Cspbbr3 Perovskite Nanocrystal: A Robust Photocatalyst for Realizing No Abatement. ACS EST Eng 1(6):1021–1027 + + 10.1021/acsestengg.1c00089 + + + + Zeng QM, Chen JW, Wan YS, Ni JP, Ni CS, Chen H (2022) Immobilizing Tio2 on nickel foam for an enhanced photocatalysis in No abatement under visible light. J Mater Sci 57(33):15722–15736 + + 10.1007/s10853-022-07628-4 + + + + Zhang L, Zeng Q, Wang K (2017) Pressure-induced structural and optical properties of inorganic halide perovskite Cspbbr3. J Phys Chem Lett 8(16):3752–3758 + + 10.1021/acs.jpclett.7b01577 + + + + Zhu HL, Liang Z, Huo Z, Ng WK, Mao J, Wong KS, Yin WJ, Choy WC (2018) Low-bandgap methylammonium-rubidium cation Sn-rich perovskites for efficient ultraviolet–visible–near infrared photodetectors. Adv Funct Mater 28(16):1706068 + + 10.1002/adfm.201706068 + + + + +
+ + + 36917383 + + 2023 + 03 + 14 + +
+ + 1614-7499 + + + 2023 + Mar + 14 + + + Environmental science and pollution research international + Environ Sci Pollut Res Int + + Comprehensive evaluation of sewage sludge anaerobic digestion process with different digestate treatments. + 10.1007/s11356-023-26214-y + + Anaerobic digestion is one of the most promising methods for reducing sewage sludge and recovering energy. In the present study, a comparative life cycle assessment (LCA) of sewage sludge anaerobic digestion processes with different digestate treatments, including mesophilic anaerobic digestion with digestate landfilling (CAD-1) and digestate incineration (CAD-2), thermophilic anaerobic digestion combined with thermal hydrolysis pre-treatment with digestate land use (THPAD-1), and digestate incineration (THPAD-2), was performed to evaluate their environmental, resource, economic, and comprehensive performances using the SimaPro software. Environmental impact analysis revealed marine ecotoxicity, freshwater ecotoxicity, and human carcinogenic toxicity as the most obvious impacts, resulting in the most significant damage to human health. Resource analysis indicated that anaerobic digestion combined with cogeneration and digestate incineration is advantageous to high energy recovery, but digestate incineration is disadvantageous to economic performance because of increased investment costs. Comparison of the four processes revealed that THPAD-2 results in the largest environmental damage, whereas CAD-1 has the smallest load. Meanwhile, THPAD-2 and THPAD-1 exhibit the best resource performance and net economic benefit, respectively. The comprehensive evaluation indices revealed that THPAD-1 and CAD-2 show better comprehensive performance. And the deep drying incineration process exhibited better comprehensive performance than sewage sludge anaerobic digestion processes. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Zhang + Xiaoyong + X + + Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education, School of Energy and Environment, Southeast University, Nanjing, 210096, China. + + + + Wang + Zhenjiang + Z + + Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education, School of Energy and Environment, Southeast University, Nanjing, 210096, China. + + + + Peng + Xiaowei + X + + Shenzhen Energy Environment Co., Ltd, Shenzhen, 518000, China. + + + + Xiao + Jun + J + http://orcid.org/0000-0003-0002-2878 + + Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education, School of Energy and Environment, Southeast University, Nanjing, 210096, China. jxiao@seu.edu.cn. + + + + Wu + Qijing + Q + + Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education, School of Energy and Environment, Southeast University, Nanjing, 210096, China. + + + + Chen + Xiaoping + X + + Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education, School of Energy and Environment, Southeast University, Nanjing, 210096, China. + + + + eng + + + 2020YFC1908703 + National Key Research and Development Program of China + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Environ Sci Pollut Res Int + 9441769 + 0944-1344 + + IM + + Anaerobic digestion + Comprehensive evaluation + Digestate treatment + Environmental impact + Life cycle assessment + Sewage sludge + +
+ + + + 2022 + 10 + 31 + + + 2023 + 02 + 26 + + + 2023 + 3 + 14 + 12 + 20 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917383 + 10.1007/s11356-023-26214-y + 10.1007/s11356-023-26214-y + + + References + + Abelleira-Pereira JM, Perez-Elvira SI, Sanchez-Oneto J, de la Cruz R, Portela JR, Nebot E (2015) Enhancement of methane production in mesophilic anaerobic digestion of secondary sewage sludge by advanced thermal hydrolysis pretreatment. Water Res 71:330–340. https://doi.org/10.1016/j.watres.2014.12.027 + + 10.1016/j.watres.2014.12.027 + + + + Appels L, Baeyens J, Degreve J, Dewil R (2008) Principles and potential of the anaerobic digestion of waste-activated sludge. 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+ + + 36917382 + + 2023 + 03 + 14 + +
+ + 1614-7499 + + + 2023 + Mar + 14 + + + Environmental science and pollution research international + Environ Sci Pollut Res Int + + A review on natural based deep eutectic solvents (NADESs): fundamentals and potential applications in removing heavy metals from soil. + 10.1007/s11356-023-26288-8 + + Natural based deep eutectic solvent (NADES) is a promising green solvent to replace the conventional soil washing solvent due to the environmental benign properties such as low toxicity, high biodegradability, high polarity or hydrophilicity, and low cost of fabrication process. The application of NADES is intensively studied in the extraction of organic compounds or natural products from vegetations or organic matters. Conversely, the use of the solvent in removing heavy metals from soil is severely lacking. This review focuses on the potential application of NADES as a soil washing agent to remove heavy metal contaminants. Hydrophilicity is an important feature of a NADES to be used as a soil washing solvent. In this context, choline chloride is often used as hydrogen bond acceptor (HBA) whereby choline chloride based NADESs showed excellent performance in the extraction of various solutes in the past studies. The nature of NADES along with its chemistry, preparation and designing methods as well as potential applications were comprehensively reviewed. Subsequently, related studies on choline chloride-based NADES in heavy metal polluted soil remediation were also reviewed. Potential applications in removing other soil contaminants as well as the limitations of NADES were discussed based on the current advancements of soil washing and future research directions were also proposed. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Lai + Zhi Ying + ZY + + Department of Chemical Engineering and Energy Sustainability, Faculty of Engineering, Universiti Malaysia Sarawak (UNIMAS), 94300, Kota Samarahan, Sarawak, Malaysia. + + + + Yiin + Chung Loong + CL + http://orcid.org/0000-0002-1197-8536 + + Department of Chemical Engineering and Energy Sustainability, Faculty of Engineering, Universiti Malaysia Sarawak (UNIMAS), 94300, Kota Samarahan, Sarawak, Malaysia. clyiin@unimas.my. + + + Institute of Sustainable and Renewable Energy (ISuRE), Universiti Malaysia Sarawak (UNIMAS), 94300, Kota Samarahan, Sarawak, Malaysia. clyiin@unimas.my. + + + + Lock + Serene Sow Mun + SSM + + CO2 Research Center (CO2RES), Department of Chemical Engineering, Universiti Teknologi PETRONAS, 32610, Seri Iskandar, Malaysia. + + + + Chin + Bridgid Lai Fui + BLF + + Department of Chemical and Energy Engineering, Faculty of Engineering and Science, Curtin University Malaysia, CDT 250, 98009, Miri, Sarawak, Malaysia. + + + Energy and Environment Research Cluster, Faculty of Engineering and Science, Curtin University Malaysia, CDT 250, 98009, Miri, Sarawak, Malaysia. + + + + Zauzi + Nur Syuhada Ahmad + NSA + + Department of Chemical Engineering and Energy Sustainability, Faculty of Engineering, Universiti Malaysia Sarawak (UNIMAS), 94300, Kota Samarahan, Sarawak, Malaysia. + + + + Sar-Ee + Sherena + S + + Department of Chemical Engineering and Energy Sustainability, Faculty of Engineering, Universiti Malaysia Sarawak (UNIMAS), 94300, Kota Samarahan, Sarawak, Malaysia. + + + + eng + + + FRGS/1/2020/TK0/UNIMAS/03/2 + Ministry of Higher Education, Malaysia, Fundamental Research Grant Scheme + + + + + Journal Article + Review + + + 2023 + 03 + 14 + +
+ + Germany + Environ Sci Pollut Res Int + 9441769 + 0944-1344 + + IM + + Green solvent + Heavy metal + Natural based deep eutectic solvent + Soil washing + +
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Chinese Medicine 13:20. https://doi.org/10.1186/s13020-018-0177-x + + 10.1186/s13020-018-0177-x + + + + Zhang WH, Chen MN, Hao Y, Jiang X, Zhou XL, Zhang ZH (2019) Choline chloride and lactic acid: A natural deep eutectic solvent for one-pot rapid construction of spiro[indoline-3,4’-pyrazolo[3,4-b]pyridines]. J Mol Liq 278:124–129. https://doi.org/10.1016/j.molliq.2019.01.065 + + 10.1016/j.molliq.2019.01.065 + + + + Zhang H, Xu YX, Kanyerere T, Wang YS, Sun MH (2022) Washing reagents for remediating heavy-metal-contaminated soil: A review. Front Earth Sci 10. https://doi.org/10.3389/feart.2022.901570 + + + Zwolak A, Sarzyńska M, Szpyrka E, Stawarczyk K (2019) Sources of soil pollution by heavy metals and their accumulation in vegetables: A review. Water Air Soil Pollut 230(7):1–9. https://doi.org/10.1007/s11270-019-4221-y + + 10.1007/s11270-019-4221-y + + + + +
+ + + 36917391 + + 2023 + 03 + 14 + +
+ + 1614-7499 + + + 2023 + Mar + 14 + + + Environmental science and pollution research international + Environ Sci Pollut Res Int + + Correction to: Assessing key indicators of efficient green energy production for IEA members. + 10.1007/s11356-023-26435-1 + + + Kasradze + Mariam + M + + Kaunas Faculty, Vilnius University, Muitines 8, 44280, Kaunas, Lithuania. + + + + Saraji + Mahyar Kamali + MK + + Kaunas Faculty, Vilnius University, Muitines 8, 44280, Kaunas, Lithuania. + + + + Streimikiene + Dalia + D + http://orcid.org/0000-0002-3247-9912 + + Kaunas Faculty, Vilnius University, Muitines 8, 44280, Kaunas, Lithuania. dalia.streimikiene@lei.lt. + + + + Ciegis + Remigijus + R + + Kaunas Faculty, Vilnius University, Muitines 8, 44280, Kaunas, Lithuania. + + + + eng + + Published Erratum + + + 2023 + 03 + 14 + +
+ + Germany + Environ Sci Pollut Res Int + 9441769 + 0944-1344 + + IM + + + Environ Sci Pollut Res Int. 2023 Mar 9;: + 36892693 + + +
+ + + + 2023 + 3 + 14 + 12 + 20 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917391 + 10.1007/s11356-023-26435-1 + 10.1007/s11356-023-26435-1 + + +
+ + + 36917384 + + 2023 + 03 + 14 + +
+ + 1614-7499 + + + 2023 + Mar + 14 + + + Environmental science and pollution research international + Environ Sci Pollut Res Int + + Influence of interflow carbonate-clay association for groundwater fluoride contamination in eastern Deccan, central India. + 10.1007/s11356-023-26392-9 + + In central India, fluoride contamination in deeper basaltic aquifer is geogenic. This study demonstrates the source of fluorine enrichment in aquifer matrix and its release mechanism into groundwater. Magmatic-hydrothermal residual melt, i.e., albitic-calcic-amphibole-apatite-rich intrusive rock is the main source of fluorine enrichment. The association of this rock with interflow carbonate-clay assemblage played a significant role for fluoride contamination. Fluorine-enriched residual melt interacted with interflow carbonate-clay association, and this interaction metasomatized the carbonates and enhanced fluorine concentration in sediments. Bulk fluorine concentration of 988 ppm is measured in the soil developed over the association of intrusive rock and carbonate-clay assemblage. X-ray diffraction and electron-probe micro analysis confirmed the presence of fluorine-bearing and/or containing minerals, i.e., fluorite, fluorapatite, and palygorskite. The presence of bicarbonate and Na+ (from albitic feldspar) in alkaline water enhanced desorption of fluoride from clays, and dissociation from fluorapatite and fluorite from carbonate-clay assemblage, which released fluoride from aquifer matrix to groundwater. Clay horizon acts as an impervious cap on the deeper aquifer and increases the residence time of groundwater. In such favorable physico-chemical condition, fluoride released from aquifer matrix to groundwater and gradually increasing the degree of fluoride contamination. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Sinha + Sayan + S + + Geological Survey of India, Jabalpur, 482 003, India. + + + + Jha + Suparna + S + http://orcid.org/0000-0002-4479-731X + + Geological Survey of India, Jabalpur, 482 003, India. suparna1308@gmail.com. + + + + Hazra + Suparna + S + + Geological Survey of India, Jabalpur, 482 003, India. + + + + eng + + + M4ENV/NC/CR/SU-MP-JAB/2018/24881 + Ministry of Mines, Geological Survey of India + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Environ Sci Pollut Res Int + 9441769 + 0944-1344 + + IM + + Carbonate-clay association + Deccan Trap + Groundwater fluoride contamination + Magmatic-hydrothermal phenomenon + Residual basaltic melt + Rock-water interaction + +
+ + + + 2022 + 09 + 14 + + + 2023 + 03 + 07 + + + 2023 + 3 + 14 + 12 + 20 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917384 + 10.1007/s11356-023-26392-9 + 10.1007/s11356-023-26392-9 + + + + Akbulut A, Kadir S (2003) The geology and origin of sepiolite, palygorskite and saponite in neogene lacustrine sediments of the Serinhisar-Acipayam basin, Denizli, SW Turkey. Clay Clay Miner 51(3):279–292 + + 10.1346/CCMN.2003.0510304 + + + + Alessandro WD (2006) Human fluorosis related to volcanic activity: a review. Environ Toxicol 10:21–30 + + + Ali S, Fakhri Y, Golbini M, Thakur SK, Alinejad A, Paresh I, Shekhar S, Bhattacharya P (2019) Concentration of fluoride in groundwater of India: a systematic review, meta-analysis and risk assessment. 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+ + + 36917386 + + 2023 + 03 + 14 + +
+ + 1614-7499 + + + 2023 + Mar + 14 + + + Environmental science and pollution research international + Environ Sci Pollut Res Int + + Public views on tourist beach environment from multinational countries and ensuing changes during global epidemic. + 10.1007/s11356-023-26277-x + + The continuous endemic of the new SARS-CoV-2 virus brought a halt to the world's activities from February 2020. Our study intends to gauge public perceptions on the consequences of post-pandemic changes on the marine environment, particularly as they are related to tourist beach amenities. Totally, 16 nations' knowledge and views on various environmental viewpoints over the effects of epidemic were gathered through public polls live on social media during social confinement in 2020. The results indicate that around 85% of respondents were most concerned about the alarming sights of widespread plastic trash and the increase of dangerous biomedical wastes through wastewater in the marine ecosystem. The outcomes of this study will undoubtedly aid in the establishment of a management strategy and for future studies on the consequences of any epidemic on the beaches. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Jeyakumar + Sakthi Selvalakshmi + SS + + Centro Interdisciplinario de Investigaciones y Estudios Sobre Medio Ambiente y Desarrollo (CIIEMAD), Instituto Politécnico Nacional (IPN), Calle 30 de Junio de 1520, Barrio La Laguna Ticomán, Del. Gustavo A. Madero, C.P.07340, Ciudad de Mexico, Mexico. + + + + Ponniah + Jonathan Muthuswamy + JM + http://orcid.org/0000-0001-9040-4911 + + Centro Interdisciplinario de Investigaciones y Estudios Sobre Medio Ambiente y Desarrollo (CIIEMAD), Instituto Politécnico Nacional (IPN), Calle 30 de Junio de 1520, Barrio La Laguna Ticomán, Del. Gustavo A. Madero, C.P.07340, Ciudad de Mexico, Mexico. mpjonathan7@yahoo.com. + + + + Vasudevan + Joshua + J + + School of Architecture Building and Civil Engineering, Loughborough University, Mumfordway, Loughborough, LE11 3TU, UK. + + + + Muñoz-Sevilla + Norma Patricia + NP + + Centro Interdisciplinario de Investigaciones y Estudios Sobre Medio Ambiente y Desarrollo (CIIEMAD), Instituto Politécnico Nacional (IPN), Calle 30 de Junio de 1520, Barrio La Laguna Ticomán, Del. Gustavo A. Madero, C.P.07340, Ciudad de Mexico, Mexico. + + + + Urrutia-Goyes + Ricardo + R + + Departamento de Ciencias de La Energía y Mecánica, Av. Gral. Rumiñahui S/N, Universidad de Las Fuerzas Armadas ESPE, P.O. Box 171-5-231B, Sangolqui, 171103, Ecuador. + + + + Escobedo-Urias + Diana Cecilia + DC + + Centro Interdisciplinario de Investigación para el Desarrollo Integral Regional (CIIDIR), Instituto Politécnico Nacional (IPN), Bulevar Juan de Dios Bátiz Paredes #250, Colonia San Joachin, C.P.81101, Guasave, Sinaloa, Mexico. + + + + Rodriguez-Espinosa + Pedro Francisco + PF + + Centro Interdisciplinario de Investigaciones y Estudios Sobre Medio Ambiente y Desarrollo (CIIEMAD), Instituto Politécnico Nacional (IPN), Calle 30 de Junio de 1520, Barrio La Laguna Ticomán, Del. Gustavo A. Madero, C.P.07340, Ciudad de Mexico, Mexico. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Environ Sci Pollut Res Int + 9441769 + 0944-1344 + + IM + + Beach qualities + Contemporary booming + Plastic litter + Post pandemic effects + SARS-CoV-2 + +
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+ + + 36917385 + + 2023 + 03 + 14 + +
+ + 1614-7499 + + + 2023 + Mar + 14 + + + Environmental science and pollution research international + Environ Sci Pollut Res Int + + Analysis and comparison of the performance parameters of passive and active indirect solar dryers with heat storage facility while drying carrot. + 10.1007/s11356-023-26400-y + + The performance of passive and active convection indirect solar drying systems provisioned with paraffin wax as heat storage was examined while drying carrot slices. The passive indirect solar dryer (type-I) was made initially, and it was upgraded with solar-powered fans to promote mass flow rate. The new assembly was considered an active setup (type-II). Data collected during experiments were analyzed to determine performance parameters and drying kinetics. There were average improvements of 11.8%, 12.2%, and 20.7% in actual heat supply, activation energy, and specific energy consumption in type-II compared to type-I. The averaged values of collector efficiency of type-I and type-II were 59.7 and 67.8%, and the drying efficiency was 11.1 and 14.2%, respectively, while their respective improvements were 13.6 and 27.93%. It was found that the coefficients of moisture diffusion (De), heat transfer (h), mass transfer (hm), and the rate of specific moisture extraction were increased by 20.83%, 16.9%, 14.52%, and 27.8%, respectively in type-II compared to type-I. A logarithmic correlation was observed for De, h, and hm demonstrating a decrease in moisture content (MC) increased the variables. The MC was diminished from 9.13 to 0.478 kg/kg of db in 15 h in type-I and 12 h in type-II with a 3 h saving in drying time with a better drying rate in type-II. The reliability of the results was assessed with uncertainty analysis. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Gilago + Mulatu Chake + MC + + Mechanical Engineering Department, National Institute of Technology Warangal, Warangal, Telangana, India, 506004. + + + Mechanical Engineering Department, Wachemo University, Hosaena City, Ethiopia. + + + + Mugi + Vishnuvardhan Reddy + VR + + Mechanical Engineering Department, National Institute of Technology Warangal, Warangal, Telangana, India, 506004. + + + + Velayudhan Parvathy + Chandramohan + C + http://orcid.org/0000-0002-8680-8363 + + Mechanical Engineering Department, National Institute of Technology Warangal, Warangal, Telangana, India, 506004. vpcm80@nitw.ac.in. + + + + eng + + + NITW/MED/Head/2015/408 dated 3rd Dec. 2015 + Mechanical Engineering Department, NIT Warangal, India + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Environ Sci Pollut Res Int + 9441769 + 0944-1344 + + IM + + Carrot + Drying kinetics + Efficiency + Indirect solar dryer + Performance parameters + Thermal energy storage materials + +
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+ + + 36917389 + + 2023 + 03 + 14 + +
+ + 1614-7499 + + + 2023 + Mar + 14 + + + Environmental science and pollution research international + Environ Sci Pollut Res Int + + Risk assessment of the antibiotic amoxicillin on non-toxin-producing strains and toxin-producing strains of Microcystis. + 10.1007/s11356-023-26403-9 + + Amoxicillin (AMX) is a common antibiotic used to treat a variety of infectious illnesses in humans and animals, including otitis media, tonsillitis, tonsillopharyngitis, laryngitis, and pharyngitis. The drug ends up in the aquatic ecosystems through animal and human excretion and industrial effluents. The ecological consequences of broad-spectrum antibiotics on non-target species like cyanobacteria are causing considerable concern. The danger of amoxicillin to non-toxin-producing and toxin-producing strains of cyanobacteria is poorly understood. The objective of this study was to analyze the risk (RQ) and physiological effects of AMX on Microcystis aeruginosa EAWAG 198 (non-toxin producing = NTP), Microcystis aeruginosa LE3 (toxin-producing = TP), and Microcystis flos aquae UTEX-LB 2677 (toxin-producing = TP). Our study showed differences in the RQ of the drug to the tested organisms - demonstrating < Microcystis flos aquae UTEX-LB 2677 > Microcystis aeruginosa LE3 > Microcystis aeruginosa EAWAG 198. The calculated EC50 values show that AMX was more toxic to the toxin-producing strains than the non-toxin-producing strains. Amoxicillin led to significant (p < 0.05) growth inhibition and chlorophyll-a content of the exposed cultures. The observed increase in the concentration of intracellular hydrogen peroxide (H2O2) of the exposed cultures at 96 h was significant (p < 0.05), demonstrating that the expressed oxidative stress patterns observed during the study were due to AMX. The current study shows significant variation (p < 0.05) in melondialdehyde (MDA) content and the antioxidant enzymes - glutathione-S-transferase (GST) and peroxidase (POD). + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Yisa + Abraham Gana + AG + + Department of Zoology, Ahmadu Bello University, Zaria, Nigeria. + + + + Chia + Mathias Ahii + MA + http://orcid.org/0000-0002-3549-5475 + + Department of Botany, Ahmadu Bello University, Zaria, Nigeria. chia28us@yahoo.com. + + + + Sha'aba + Ramatu Idris + RI + + Department of Biology, Ahmadu Bello University, Zaria, Nigeria. + + + + Gauje + Balli + B + + National Institute for Chemical Technology, Zaria, Nigeria. + + + + Gadzama + Ibrahim Madu Katsallah + IMK + + Department of Biology, Ahmadu Bello University, Zaria, Nigeria. + + + + Oniye + Sonnie Joshua + SJ + + Department of Zoology, Ahmadu Bello University, Zaria, Nigeria. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Environ Sci Pollut Res Int + 9441769 + 0944-1344 + + IM + + Amoxicillin + Biochemical composition + Microcystis + Physiology + Risk assessment + +
+ + + + 2021 + 09 + 18 + + + 2023 + 03 + 07 + + + 2023 + 3 + 14 + 12 + 20 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917389 + 10.1007/s11356-023-26403-9 + 10.1007/s11356-023-26403-9 + + + + Ando T, Nagase H, Eguchi K et al (2007) A novel method using cyanobacteria for ecotoxicity test of veterinary antimicrobial agents. Environ Toxicol Chem an Int J 26:601–606 + + 10.1897/06-195R.1 + + + + Azevedo FCR, Vaz ICD, Barbosa FAR, Magalhães SMS (2019) Toxicological effects of ciprofloxacin and chlorhexidine on growth and chlorophyll a synthesis of freshwater cyanobacteria. Braz J Pharm Sci 55:1–11 + + + Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anals Biochem 72:248–254 + + + Chia MA, Ameh I, Agee JT et al (2021a) Effects of the antimalarial lumefantrine on Lemna minor, Raphidocelis subcapitata and Chlorella vulgaris. 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+ + + 36917394 + + 2023 + 03 + 14 + +
+ + 1573-6628 + + + 2023 + Mar + 14 + + + Maternal and child health journal + Matern Child Health J + + Use of Cellular-Enabled Remote Patient Monitoring Device for Hypertension Management in Pregnant Women: A Feasibility Study. + 10.1007/s10995-023-03628-1 + + Hypertension affects 5-10% of pregnancies in the United States. Chronic hypertension during pregnancy can have a significant impact on maternal and neonatal outcomes, especially in rural populations. Pregnancies complicated by hypertension are currently managed through frequent clinic visits or extended hospital stays. Cellular-enabled remote patient monitoring devices provide an alternative treatment method for women in rural areas. + This study aimed to measure the feasibility of and patient satisfaction with using an integrated model of cellular-enabled remote patient monitoring devices for blood pressure supported by a 24/7 nurse call center. + In a mixed methods pilot study, twelve women with chronic hypertension during pregnancy were given cellular-enabled BodyTrace blood pressure cuffs and weight scales. Participants' blood pressures were continuously monitored by a nurse call center. Participants completed a survey and a brief semi-structured interview after two weeks. + Participants scored low on stress and anxiety with mean scores of 5.45 (SD = 3.56) and 8.09 (SD 3.62), respectively. Participants scored high on behavioral intention, system usability, and perceived benefits with mean scores of 8.73 (SD = 2.53), 75.91 (SD = 23.70), and 19.64 (SD = 5.92), respectively. Participants perceived benefits to using the device, including increased monitoring by health professionals, increased self-awareness, decreased number of clinic visits, and convenience of use. Perceived disadvantages included higher readings when compared to clinical readings. + Cellular-enabled remote patient monitoring devices for blood pressure are a valuable tool for managing treatment of pregnancies complicated by hypertension. + © 2023. The Author(s). + + + + D Jones + Rebecca + R + http://orcid.org/0000-0001-8667-1347 + + University of Arkansas for Medical Sciences, 4301 West Markham Street Little Rock, Little Rock, AR, 72223, USA. rdjones@uams.edu. + + + + Allison + M Kathryn + MK + + University of Arkansas for Medical Sciences, 4301 West Markham Street Little Rock, Little Rock, AR, 72223, USA. + + + + Moody + Heather + H + + University of Arkansas for Medical Sciences, 4301 West Markham Street Little Rock, Little Rock, AR, 72223, USA. + + + + Peng + Cheng + C + + University of Arkansas for Medical Sciences, 4301 West Markham Street Little Rock, Little Rock, AR, 72223, USA. + + + + Eswaran + Hari + H + + University of Arkansas for Medical Sciences, 4301 West Markham Street Little Rock, Little Rock, AR, 72223, USA. + + + + eng + + + UL1 TR003107 + Translational Research Institute, University of Arkansas for Medical Sciences + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Matern Child Health J + 9715672 + 1092-7875 + + IM + + Previous research on remote patient monitoring (RPM) for hypertension management in postpartum and pregnant women found high participant satisfaction, decrease in blood pressure (BP) rates, increased BP management, and overall positive perceptions. This is the first study to assess the feasibility and acceptability of cellular-enabled RPM BP devices, which do not require a smartphone or app, combined with a 24/7 nurse call center with continuous BP monitoring and response to high readings for better care management. This mixed-method study explored patient satisfaction with the integrated BP system and perceived advantages and disadvantages of the device. + + + Cellular-enabled remote patient monitoring device + Hypertension + Pregnancy + Pregnant women + Remote patient monitoring + +
+ + + + 2023 + 02 + 15 + + + 2023 + 3 + 14 + 12 + 20 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917394 + 10.1007/s10995-023-03628-1 + 10.1007/s10995-023-03628-1 + + + + Ananth, C. V., Keyes, K. M., & Wapner, R. J. (2013). Pre-eclampsia rates in the United States, 1980–2010: age-period-cohort analysis. Bmj, 347. + + + Bello, N. A., Miller, E., Cleary, K., Wapner, R., Shimbo, D., & Tita, A. T. (2018a). Out of office blood pressure measurement in pregnancy and the postpartum period. Current hypertension reports, 20(12), 1–8. + + 10.1007/s11906-018-0901-z + + + + Bello, N. A., Woolley, J. J., Cleary, K. L., Falzon, L., Alpert, B. S., Oparil, S., & Shimbo, D. (2018b). Accuracy of blood pressure measurement devices in pregnancy: a systematic review of validation studies. Hypertension, 71(2), 326–335. + + 10.1161/HYPERTENSIONAHA.117.10295 + 29229741 + + + + Brooke, J. (1996). 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Using mHealth in postpartum women with pre-eclampsia: Lessons learned from a qualitative study. International Journal of Gynecology & Obstetrics, 149(3), 339–346. + + 10.1002/ijgo.13134 + + + + Tucker, K. L., Taylor, K. S., Crawford, C., Hodgkinson, J. A., Bankhead, C., Carver, T., & McManus, R. J. (2017). Blood pressure self-monitoring in pregnancy: examining feasibility in a prospective cohort study. BMC pregnancy and childbirth, 17(1), 1–10. + + 10.1186/s12884-017-1605-0 + + + + Rhoads, S. J., Serrano, C. I., Lynch, C. E., Ounpraseuth, S. T., Gauss, C. H., Payakachat, N., & Eswaran, H. (2017). Exploring implementation of m-health monitoring in postpartum women with hypertension. Telemedicine and e-Health, 23(10), 833–841. + + 10.1089/tmj.2016.0272 + 28475431 + 5651969 + + + + Rural Health Information Hub. Healthcare Access in Rural Communities: Introduction (2019). ; https://www.ruralhealthinfo.org/topics/healthcare-access#services . + + + +
+ + + 36917388 + + 2023 + 03 + 14 + +
+ + 1614-7499 + + + 2023 + Mar + 14 + + + Environmental science and pollution research international + Environ Sci Pollut Res Int + + Association of biomass fuel use with the risk of vision impairment among Chinese older adults: a cohort study. + 10.1007/s11356-023-26325-6 + + Cooking with biomass fuels has been reported to have adverse effects on health. This study aims to explore the association between cooking with biomass fuels and vision impairment among Chinese older adults aged 65 years and above. This cohort study drew on data from the 2011/2012 wave and the 2014 follow-up wave of the Chinese Longitudinal Healthy Longevity Survey. Participants' visual function was examined through a vision screening test. Exposure to indoor biomass fuels was self-reported. Cox proportional hazards models were applied to explore the relationship between biomass fuel use and vision impairment. Additionally, we compared the risk of vision impairment between participants who switched cooking fuel types and those who did not. Subgroup and interaction analyses were conducted to explore the potential effect modifiers. A total of 4711 participants were included in this study. During the follow-up, 1053 (22.35%) participants developed vision impairment. Cooking with biomass fuels increased the risk of vision impairment by 40% (hazard ratio [HR]: 1.40, 95% confidence interval [CI]: 1.21-1.61). Participants who switched from clean fuels to biomass fuels had a greater risk of vision impairment than persistent clean fuel users (HR: 1.44, 95% CI: 1.03-2.00). Greater effect estimates were found in participants who lived in eastern and central China and urban residents. Cooking with biomass fuels resulted in a greater risk of vision impairment among Chinese older adults. This risk also existed in those who changed their cooking fuels from clean fuels to biomass fuels. Further studies with an objective assessment of biomass fuel combustion are required to confirm our findings. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + Zhou + Ying + Y + + Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan, 430030, Hubei, China. + + + + Xu + Minzhi + M + + Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan, 430030, Hubei, China. + + + + Ke + Pan + P + + Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan, 430030, Hubei, China. + + + + Di + Hongkun + H + + Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan, 430030, Hubei, China. + + + + Gan + Yong + Y + + Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan, 430030, Hubei, China. + + + + Feng + Jing + J + + Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan, 430030, Hubei, China. + + + + Meng + Xin + X + + Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan, 430030, Hubei, China. + + + + Su + Cheng + C + + Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan, 430030, Hubei, China. + + + + Tian + Qingfeng + Q + + School of Public Health, Zhengzhou University, Zhengzhou, Henan, China. + + + + Lu + Zuxun + Z + + Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan, 430030, Hubei, China. zuxunlu@hust.edu.cn. + + + + eng + + + 18ZDA085 + National Social Science Fund of China + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Environ Sci Pollut Res Int + 9441769 + 0944-1344 + + IM + + Biomass fuel + Clean fuel + Cohort study + Cooking fuel + Elderly population + Vision impairment + +
+ + + + 2022 + 09 + 20 + + + 2023 + 03 + 03 + + + 2023 + 3 + 14 + 12 + 20 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917388 + 10.1007/s11356-023-26325-6 + 10.1007/s11356-023-26325-6 + + + References + + Bai R, Lam JCK, Li VOK (2018) A review on health cost accounting of air pollution in China. Environ Int 120:279–294. https://doi.org/10.1016/j.envint.2018.08.001 + + 10.1016/j.envint.2018.08.001 + + + + Banerjee M, Siddique S, Dutta A, Mukherjee B, Ranjan RM (2012) Cooking with biomass increases the risk of depression in pre-menopausal women in India. Soc Sci Med 75(3):565–572. https://doi.org/10.1016/j.socscimed.2012.03.021 + + 10.1016/j.socscimed.2012.03.021 + + + + Burroughs Peña M, Romero KM, Velazquez EJ, Davila-Roman VG, Gilman RH, Wise RA, Miranda JJ, Checkley W (2015) Relationship between daily exposure to biomass fuel smoke and blood pressure in high-altitude Peru. 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+ + + 36917390 + + 2023 + 03 + 14 + +
+ + 1614-7499 + + + 2023 + Mar + 14 + + + Environmental science and pollution research international + Environ Sci Pollut Res Int + + Quantitation of pesticides in bee bread collected from honey bee colonies in an agricultural environment in Switzerland. + 10.1007/s11356-023-26268-y + + Pesticide contamination of bee products is a widespread phenomenon. Due to its composition, bee bread is affected by both lipophilic and hydrophilic substances. As proof of concept of a monitoring campaign and to better understand the extent of contamination, we developed an analytical method based on a modified QuEChERS extraction, with subsequent separation by liquid chromatography and detection by mass spectrometry. This allowed for the quantitation of 51 agricultural- or beekeeping-associated pesticides in bee bread. The workflow was applied to 60 samples taken biweekly throughout spring to autumn 2022 from five colonies at a Swiss apiary in an agricultural area. In total, 30 pesticides were identified (> LOD), among which 26 pesticides were quantitated. The total number of pesticides detected per colony ranged from 11 to 19. The most prevalent substances (> LOQ) were two neonicotinoid insecticides, acetamiprid and thiacloprid (max. 16 μg/kg and 37 μg/kg, respectively); seven fungicides, azoxystrobin (max. 72 μg/kg), boscalid (max. 50 μg/kg), cyprodinil (max. 1965 μg/kg), difenoconazole (max. 73 μg/kg), mandipropamid (max. 33 μg/kg), pyraclostrobin (max. 8 μg/kg) and trifloxystrobin (max. 38 μg/kg); and two herbicides, prosulfocarb (max. 38 μg/kg) and terbuthylazine (max. 26 μg/kg). The study revealed strong variability in pesticide occurrence and concentrations among colonies sampled at the same site and date. The applied biweekly sampling of bee bread from March to August was shown to be reliable in capturing peak contaminations and revealing the onset of certain pesticides in bee bread. The study provides an adequate practical approach for pesticide monitoring campaigns. + © 2023. The Author(s). + + + + Schaad + Emmanuel + E + https://orcid.org/0000-0002-9203-6750 + + Swiss Bee Research Centre, Agroscope, Schwarzenburgstrasse 161, 3003, Bern, Switzerland. + + + + Fracheboud + Marion + M + + Swiss Bee Research Centre, Agroscope, Schwarzenburgstrasse 161, 3003, Bern, Switzerland. + + + + Droz + Benoît + B + + Swiss Bee Research Centre, Agroscope, Schwarzenburgstrasse 161, 3003, Bern, Switzerland. + + + + Kast + Christina + C + http://orcid.org/0000-0002-5673-6848 + + Swiss Bee Research Centre, Agroscope, Schwarzenburgstrasse 161, 3003, Bern, Switzerland. christina.kast@agroscope.admin.ch. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Environ Sci Pollut Res Int + 9441769 + 0944-1344 + + IM + + Apis mellifera + Bee bread + Pesticides + Pollen + QuEChERS + Residues + UHPLC-MS/MS + +
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+ + + 36917392 + + 2023 + 03 + 14 + +
+ + 1749-0774 + + + 2023 + Mar + 14 + + + Human cell + Hum Cell + + Identification of LBH and SPP1 involved in hepatic stellate cell activation during liver fibrogenesis. + 10.1007/s13577-023-00889-4 + + Liver fibrosis is a pathological response driven by the activation of hepatic stellate cell (HSC). However, the mechanisms of liver fibrosis and HSC activation are complicated and far from being fully understood. We aimed to explore the candidate genes involved in HSC activation during liver fibrogenesis. Five genes (LBH, LGALS3, LOXL1, S100A6 and SPP1) were recurrent in the DEGs derived from the seven datasets. The expression of these genes gradually increased as liver fibrosis staging advanced, suggesting they might be candidate genes involved in HSC activation during hepatic fibrosis. These candidate genes were predicted to be coregulated by miRNAs such as hsa-miR-125a-5p and has-miR-125b, or by transcription factors including JUN, USF1, TP53 and TFAP2C. PPI analysis showed that LGALS3, LOXL1, S100A6 and SPP1 might interact with each other indirectly, but no interaction was found between them and LBH. The candidate genes and their interaction partners were enriched in focal adhesion, extracellular matrix organization and binding. Upregulation of LBH, S100A6 and SPP1 were further validated in TGF-β-treated LX-2 as well as in DDC or CCL4-treated mice models. Decreased LBH and SPP1 expression reduces the expression of HSC activation-related markers in TGF-β-treated LX-2. Our results indicated that LBH, LGALS3, LOXL1, S100A6 and SPP1 were candidate genes which may participate in the HSC activation during liver fibrosis. + © 2023. The Author(s) under exclusive licence to Japan Human Cell Society. + + + + Dai + Weiming + W + + Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. + + + Shanghai Key Laboratory of Pancreatic Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China. + + + + Guo + Yuecheng + Y + + Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. + + + Shanghai Key Laboratory of Pancreatic Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China. + + + + Shen + Zhenyang + Z + + Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. + + + Shanghai Key Laboratory of Pancreatic Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China. + + + + Wang + Junjun + J + + Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. + + + Shanghai Key Laboratory of Pancreatic Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China. + + + + Lu + Lungen + L + + Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. + + + Shanghai Key Laboratory of Pancreatic Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China. + + + + Dong + Hui + H + + Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. hui.dong@shgh.cn. + + + Shanghai Key Laboratory of Pancreatic Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China. hui.dong@shgh.cn. + + + + Cai + Xiaobo + X + http://orcid.org/0000-0001-7697-5873 + + Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. xiaobo.cai@shgh.cn. + + + + eng + + + 81970528 + the National Natural Science Foundation of China + + + + 22ZR1449700 + Shanghai Municipal Science and Technology Commission Research Project + + + + 02.06.01.20.01 + Shanghai General Hospital Start-up Fund + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + Japan + Hum Cell + 8912329 + 0914-7470 + + IM + + Differentially expressed gene + Hepatic stellate cell + Liver fibrosis + Protein–protein interaction + +
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+ + + 36917393 + + 2023 + 03 + 14 + +
+ + 1559-0720 + + + 2023 + Mar + 14 + + + Biological trace element research + Biol Trace Elem Res + + Effects of Sr2+, BO33-, and SiO32- on Differentiation of Human Dental Pulp Stem Cells into Odontoblast-Like Cells. + 10.1007/s12011-023-03625-z + + This study aimed to clarify the effects of strontium (Sr2+), borate (BO33-), and silicate (SiO32-) on cell proliferative capacity, the induction of differentiation into odontoblast-like cells (OLCs), and substrate formation of human dental pulp stem cells (hDPSCs). Sr2+, BO33-, and SiO32- solutions were added to the hDPSC culture medium at three different concentrations, totaling nine experimental groups. The effects of these ions on hDPSC proliferation, calcification, and collagen formation after 14, 21, and 28 days of culture were evaluated using a cell proliferation assay, a quantitative alkaline phosphatase (ALP) activity assay, and Alizarin Red S and Sirius Red staining, respectively. Furthermore, the effects of these ions on hDPSC differentiation into OLCs were assessed via quantitative polymerase chain reaction and immunocytochemistry. Sr2+ and SiO32- increased the expression of odontoblast markers; i.e., nestin, dentin matrix protein-1, dentin sialophosphoprotein, and ALP genes, compared with the control group. BO33- increased the ALP gene expression and activity. The results of this study suggested that Sr2+, BO33-, and SiO32- may induce hDPSC differentiation into OLCs. + © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. + + + + Miyano + Yuko + Y + http://orcid.org/0000-0001-6716-8279 + + Advanced Operative Dentistry-Endodontics, The Nippon Dental University Graduate School of Life Dentistry at Niigata, Nigata, Japan. + + + + Mikami + Masato + M + http://orcid.org/0000-0003-0757-5184 + + Department of Microbiology, The Nippon Dental University School of Life Dentistry at Niigata, Nigata, Japan. + + + + Katsuragi + Hiroaki + H + http://orcid.org/0000-0002-7112-5017 + + Department of Microbiology, The Nippon Dental University School of Life Dentistry at Niigata, Nigata, Japan. + + + + Shinkai + Koichi + K + http://orcid.org/0000-0002-7564-9934 + + Department of Operative Dentistry, The Nippon Dental University School of Life Dentistry at Niigata, 1-8 Hamaura-Cho, Chuo-Ku, Nigata, 951-8580, Japan. shinkaik@ngt.ndu.ac.jp. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Biol Trace Elem Res + 7911509 + 0163-4984 + + IM + + Borate + Human dental pulp stem cells + Odontogenic differentiation + S-PRG + Silicate + Strontium + +
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+ + + 36917396 + + 2023 + 03 + 14 + +
+ + 2197-1153 + + 10 + 1 + + 2023 + Mar + 14 + + + Journal of experimental orthopaedics + J Exp Orthop + + Computer-assisted analysis of functional internal rotation after reverse total shoulder arthroplasty: implications for component choice and orientation. + + 23 + + 10.1186/s40634-023-00580-5 + + Functional internal rotation (IR) is a combination of extension and IR. It is clinically often limited after reverse total shoulder arthroplasty (RTSA) either due to loss of extension or IR in extension. It was the purpose of this study to determine the ideal in-vitro combination of glenoid and humeral components to achieve impingement-free functional IR. + RTSA components were virtually implanted into a normal scapula (previously established with a statistical shape model) and into a corresponding humerus using a computer planning program (CASPA). Baseline glenoid configuration consisted of a 28 mm baseplate placed flush with the posteroinferior glenoid rim, a baseplate inclination angle of 96° (relative to the supraspinatus fossa) and a 36 mm standard glenosphere. Baseline humeral configuration consisted of a 12 mm humeral stem, a metaphysis with a neck shaft angle (NSA) of 155° (+ 6 mm medial offset), anatomic torsion of -20° and a symmetric PE inlay (36mmx0mm). Additional configurations with different humeral torsion (-20°, + 10°), NSA (135°, 145°, 155°), baseplate position, diameter, lateralization and inclination were tested. Glenohumeral extension of 5, 10, 20, and 40° was performed first, followed by IR of 20, 40, and 60° with the arm in extension of 40°-the value previously identified as necessary for satisfactory clinical functional IR. The different component combinations were taken through simulated ROM and the impingement volume (mm3) was recorded. Furthermore, the occurrence of impingement was read out in 5° motion increments. + In all cases where impingement occurred, it occurred between the PE inlay and the posterior glenoid rim. Only in 11 of 36 combinations full functional IR was possible without impingement. Anterosuperior baseplate positioning showed the highest impingement volume with every combination of NSA and torsion. A posteroinferiorly positioned 26 mm baseplate resulting in an additional 2 mm of inferior overhang as well as 6 mm baseplate lateralization offered the best impingement-free functional IR (5/6 combinations without impingement). Low impingement potential resulted from a combination of NSA 135° and + 10° torsion (4/6 combinations without impingement), followed by NSA 135° and -20° torsion (3/6 combinations without impingement) regardless of glenoid setup. + The largest impingement-free functional IRs resulted from combining a posteroinferior baseplate position, a greater inferior glenosphere overhang, 90° of baseplate inclination angle, 6 mm glenosphere lateralization with respect to baseline setup, a lower NSA and antetorsion of the humeral component. Surgeons can employ and combine these implant configurations to achieve and improve functional IR when planning and performing RTSA. + Basic Science Study, Biomechanics. + © 2023. The Author(s). + + + + Hochreiter + Bettina + B + http://orcid.org/0000-0002-5486-7705 + + Department of Orthopedics, Balgrist University Hospital, University of Zurich, Forchstrasse 340, CH-8008, Zurich, Switzerland. bettina.hochreiter@balgrist.ch. + + + + Meisterhans + Michel + M + + Department of Orthopedics, Balgrist University Hospital, University of Zurich, Forchstrasse 340, CH-8008, Zurich, Switzerland. + + + + Zindel + Christoph + C + + Department of Orthopedics, Balgrist University Hospital, University of Zurich, Forchstrasse 340, CH-8008, Zurich, Switzerland. + + + + Calek + Anna-Katharina + AK + + Department of Orthopedics, Balgrist University Hospital, University of Zurich, Forchstrasse 340, CH-8008, Zurich, Switzerland. + + + + Gerber + Christian + C + + Department of Orthopedics, Balgrist University Hospital, University of Zurich, Forchstrasse 340, CH-8008, Zurich, Switzerland. + + + Balgrist Campus, Orthopaedic Research Center, Zurich, Switzerland. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + J Exp Orthop + 101653750 + 2197-1153 + + + Baseplate + Extension + Internal rotation + Neck shaft angle + Orientation + Position + RTSA + Reverse total shoulder arthroplasty + +
+ + + + 2022 + 09 + 10 + + + 2023 + 01 + 25 + + + 2023 + 3 + 14 + 12 + 20 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917396 + 10.1186/s40634-023-00580-5 + 10.1186/s40634-023-00580-5 + + + + Beeler S, Leoty L, Hochreiter B, Carrillo F, Götschi T, Fischer T, Fürnstahl P, Gerber C (2021) Similar scapular morphology in patients with dynamic and static posterior shoulder instability. JSES Int 5:181–189 + + 33681835 + 7910728 + 10.1016/j.jseint.2020.11.003 + + + + Berhouet J, Garaud P, Favard L (2014) Evaluation of the role of glenosphere design and humeral component retroversion in avoiding scapular notching during reverse shoulder arthroplasty. J Shoulder Elbow Surg 23:151–158 + + 23850310 + 10.1016/j.jse.2013.05.009 + + + + Boileau P, Gauci M-O, Wagner ER, Clowez G, Chaoui J, Chelli M, Walch G (2019) The reverse shoulder arthroplasty angle: a new measurement of glenoid inclination for reverse shoulder arthroplasty. 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J Bone Joint Surg Br 92-B(4):535–539 + + 10.1302/0301-620X.92B4.22450 + + + + Collin P, Liu X, Denard PJ, Gain S, Nowak A, Lädermann A (2018) Standard versus bony increased-offset reverse shoulder arthroplasty: a retrospective comparative cohort study. J Shoulder Elbow Surg 27:59–64 + + 28969891 + 10.1016/j.jse.2017.07.020 + + + + Collin P, Matsukawa T, Denard PJ, Gain S, Lädermann A (2017) Pre-operative factors influence the recovery of range of motion following reverse shoulder arthroplasty. Int Orthop 41:2135–2142 + + 28791445 + 10.1007/s00264-017-3573-4 + + + + Eno JT, Kontaxis A, Novoa-Boldo A, Windsor E, Chen X, Erickson BJ, Warren RF, Dines DM, Dines JS, Gulotta LV, Taylor SA (2019) The biomechanics of subscapularis repair in reverse shoulder arthroplasty: The effect of lateralization and insertion site. J Orthop Res 38(4):888–894 + + 31743476 + 10.1002/jor.24531 + + + + Erickson BJ, Frank RM, Harris JD, Mall N, Romeo AA (2015) The influence of humeral head inclination in reverse total shoulder arthroplasty: a systematic review. J Shoulder Elbow Surg 24:988–993 + + 25725965 + 10.1016/j.jse.2015.01.001 + + + + Erickson BJ, Harris JD, Romeo AA (2016) The Effect of Humeral Inclination on Range of Motion in Reverse Total Shoulder Arthroplasty: A Systematic Review. Am J Orthop (Belle Mead NJ) 45:E174–E179 + + 27327922 + + + + Gerber C, Canonica S, Catanzaro S, Ernstbrunner L (2018) Longitudinal observational study of reverse total shoulder arthroplasty for irreparable rotator cuff dysfunction: results after 15 years. J Shoulder Elbow Surg 27:831–838 + + 29305102 + 10.1016/j.jse.2017.10.037 + + + + Gutiérrez S, Comiskey CA, Luo Z-P, Pupello DR, Frankle MA (2008) Range of Impingement-Free Abduction and Adduction Deficit After Reverse Shoulder Arthroplasty. J Bone Joint Surg 90:2606–2615 + + 19047705 + 10.2106/JBJS.H.00012 + + + + Hawkes DH, Khaiyat OA, Howard AJ, Kemp GJ, Frostick SP (2019) Patterns of muscle coordination during dynamic glenohumeral joint elevation: An EMG study. PLoS One 14:e0211800 + + 30735521 + 6368381 + 10.1371/journal.pone.0211800 + + + + Hochreiter B, Hasler A, Hasler J, Kriechling P, Borbas P, Gerber C (2021) Factors influencing functional internal rotation after reverse total shoulder arthroplasty. JSES Int 5:679–687 + + 34223415 + 8245997 + 10.1016/j.jseint.2021.03.005 + + + + Hochreiter B, Wyss S, Gerber C (2021) Extension of the Shoulder is Essential for Functional Internal Rotation After Reverse Total Shoulder Arthroplasty. J Shoulder Elbow Surg 31(6):1166–1174 + + 34968695 + 10.1016/j.jse.2021.11.006 + + + + Huish EG, Athwal GS, Neyton L, Walch G (2020) Adjusting Implant Size and Position Can Improve Internal Rotation After Reverse Total Shoulder Arthroplasty in a Three-dimensional Computational Model. Clin Orthop Relat Res 479:198–204 + + 7899712 + 10.1097/CORR.0000000000001526 + + + + Jang YH, Lee JH, Kim SH (2020) Effect of scapular notching on clinical outcomes after reverse total shoulder arthroplasty. Bone Joint J 102-B(11):1438–1445 + + 33135432 + 7954180 + 10.1302/0301-620X.102B11.BJJ-2020-0449.R1 + + + + Jassim SS, Ernstbrunner L, Ek ET (2021) Does Humeral Component Version Affect Range of Motion and Clinical Outcomes in Reverse Total Shoulder Arthroplasty? A Systematic Review J Clin Medicine 10:5745 + + + Jeon B-K, Panchal KA, Ji J-H, Xin Y-Z, Park S-R, Kim J-H, Yang S-J (2016) Combined effect of change in humeral neck-shaft angle and retroversion on shoulder range of motion in reverse total shoulder arthroplasty — A simulation study. Clin Biomech (Bristol, Avon) 31:12–19 + + 26598806 + 10.1016/j.clinbiomech.2015.06.022 + + + + Keener JD, Patterson BM, Orvets N, Aleem AW, Chamberlain AM (2018) Optimizing reverse shoulder arthroplasty component position in the setting of advanced arthritis with posterior glenoid erosion: a computer-enhanced range of motion analysis. J Shoulder Elbow Surg 27:339–349 + + 29332666 + 10.1016/j.jse.2017.09.011 + + + + Kim S-J, Jang S, Jung K-H, Kim YS, Lee S-J, Yoo Y (2018) Analysis of impingement-free range of motion of the glenohumeral joint after reverse total shoulder arthroplasty using three different implant models. J Orthop Sci 24:87–94 + + 30268356 + 10.1016/j.jos.2018.08.016 + + + + Kozak T, Bauer S, Walch G, Al-karawi S, Blakeney W (2021) An update on reverse total shoulder arthroplasty: current indications, new designs, same old problems. EFOR Open Rev 6:189–201 + + 10.1302/2058-5241.6.200085 + + + + Lädermann A, Denard PJ, Boileau P, Farron A, Deransart P, Walch G (2018) What is the best glenoid configuration in onlay reverse shoulder arthroplasty? Int Orthop 42:1339–1346 + + 29492611 + 10.1007/s00264-018-3850-x + + + + Lädermann A, Gueorguiev B, Charbonnier C, Stimec BV, Fasel JHD, Zderic I, Hagen J, Walch G (2015) Scapular Notching on Kinematic Simulated Range of Motion After Reverse Shoulder Arthroplasty Is Not the Result of Impingement in Adduction. Medicine (Baltimore) 94:e1615 + + 26402829 + 10.1097/MD.0000000000001615 + + + + Lädermann A, Tay E, Collin P, Piotton S, Chiu C-H, Michelet A, Charbonnier C (2019) Effect of critical shoulder angle, glenoid lateralization, and humeral inclination on range of movement in reverse shoulder arthroplasty. Bone Joint Res 8:378–386 + + 31537995 + 6719532 + 10.1302/2046-3758.88.BJR-2018-0293.R1 + + + + Liou W, Yang Y, Petersen-Fitts GR, Lombardo DJ, Stine S, Sabesan VJ (2017) Effect of lateralized design on muscle and joint reaction forces for reverse shoulder arthroplasty. J Shoulder Elbow Surg 26:564–572 + + 28038912 + 10.1016/j.jse.2016.09.045 + + + + Ludewig PM, Phadke V, Braman JP, Hassett DR, Cieminski CJ, LaPrade RF (2009) Motion of the Shoulder Complex During Multiplanar Humeral Elevation. J Bone Joint Surg 91:378–389 + + 19181982 + 2657311 + 10.2106/JBJS.G.01483 + + + + Maier MW, Erhard S, Niklasch M, Bruckner T, Wolf SI, Zeifang F, Raiss P (2017) Three-dimensional motion analysis for validation of shoulder internal rotation. 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+ + + 36917405 + + 2023 + 03 + 14 + +
+ + 1865-0341 + + + 2023 + Mar + 14 + + + Radiological physics and technology + Radiol Phys Technol + + Validation of the DoseCalcs Monte Carlo code for estimating the 18F S-values for ICRP adult and 15-year-old male and female phantoms. + 10.1007/s12194-023-00709-2 + + Internal radiation exposure using radiopharmaceuticals, as in nuclear medicine procedures, necessitates the estimation of the S-value to determine and improve the estimates of absorbed doses in at-risk organs and tissues. The S value is defined as the absorbed dose in the target organ per unit of nuclear transformation in the source organ. It is calculated using the specific absorbed fraction, which is an important quantity that connects the deposited energy in the target and emitting source organs. In this study, we applied DoseCalcs, a new Geant4-based tool, to estimate the S values of [Formula: see text]F using nuclear data from ICRP Publication 107. Geometrical data from ICRP Publications 110 and 143 were used to select four models representing male and female phantoms for adults and 15 years old to study the variability in the S-values arising from variations in anatomy and initial energy validations, because we used the [Formula: see text] mean energy instead of the full beta spectrum. The [Formula: see text]F-released photons and [Formula: see text] from 26 source organs were tracked using the Geant4 Livermore package. Accordingly, the S-values were calculated for 141 target organs. The results for the adult male and female phantoms were compared with the OpenDose reference data. These results agreed well with OpenDose, the average ratio for self-absorption S-values was 1.015, and the average ratios for the cross-irradiation were 1.2 and 1.22 for the AM and AF, respectively. This indicates the accuracy of DoseCalcs for subsequent use in estimating [Formula: see text]F S-values using voxelized geometries. + © 2023. The Author(s), under exclusive licence to Japanese Society of Radiological Technology and Japan Society of Medical Physics. + + + + El Ghalbzouri + Tarik + T + http://orcid.org/0000-0002-8571-7574 + + ERSN Laboratory, Physics Department, Faculty of Sciences, University Abdelmalek Essaadi, Tetouan, Morocco. imttarikk@gmail.com. + + + + El Bardouni + Tarek + T + + ERSN Laboratory, Physics Department, Faculty of Sciences, University Abdelmalek Essaadi, Tetouan, Morocco. + + + + El Bakkali + Jaafar + J + + ERSN Laboratory, Physics Department, Faculty of Sciences, University Abdelmalek Essaadi, Tetouan, Morocco. + + + Nuclear Medicine Department, Military Hospital Mohammed V, Rabat, Morocco. + + + + Ziani + Hafssa + H + + ERSN Laboratory, Physics Department, Faculty of Sciences, University Abdelmalek Essaadi, Tetouan, Morocco. + + + + Doudouh + Abderrahim + A + + ERSN Laboratory, Physics Department, Faculty of Sciences, University Abdelmalek Essaadi, Tetouan, Morocco. + + + Nuclear Medicine Department, Military Hospital Mohammed V, Rabat, Morocco. + + + Faculty of Medicine and Pharmacy, University Mohammed V Souissi, Rabat, Morocco. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Japan + Radiol Phys Technol + 101467995 + 1865-0333 + + IM + + Computational phantom + DoseCalcs + Geant4 + Monte Carlo + Nuclear medicine + S-value + +
+ + + + 2022 + 12 + 05 + + + 2023 + 03 + 02 + + + 2023 + 03 + 01 + + + 2023 + 3 + 14 + 12 + 20 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917405 + 10.1007/s12194-023-00709-2 + 10.1007/s12194-023-00709-2 + + + + Ollinger JM, Fessler JA. Positron-emission tomography. Ieee Signal Process Mag. 1997;14(1):43–55. + + 10.1109/79.560323 + + + + McKeighen RE. A review of gamma camera technology for medical imaging. Nuclear Med Ultrasonics Thermogr. 1980; chap. 4, p. 119–63. + + + Huang B, Law MW-M, Khong P-L. Whole-body PET/CT scanning: estimation of radiation dose and cancer risk. Radiology. 2009;251:166–74. + + 10.1148/radiol.2511081300 + 19251940 + + + + Glatting G, Lassmann M. Nuclear medicine dosimetry: quantitative imaging and dose calculations. Z Med Phys. Dec.2011;21:246–7. + + 10.1016/j.zemedi.2011.07.005 + 21862300 + + + + Endo M. History of medical physics. Radiol Phys Technol. 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+ + + 36917397 + + 2023 + 03 + 14 + +
+ + 2196-8837 + + + 2023 + Mar + 14 + + + Journal of racial and ethnic health disparities + J Racial Ethn Health Disparities + + Vigilance and Protection: How Asian and Pacific Islander, Black, Latina, and Middle Eastern Women Cope with Racism. + 10.1007/s40615-023-01560-2 + + Research is needed to fully investigate the differential mechanisms racial and ethnic groups use to deal with ongoing intersectional racism in women's lives. The aim of this paper was to understand how Asian American and Pacific Islander, Black, Latina, and Middle Eastern women experience racism-from personal perceptions and interactions to coping mechanisms and methods of protection. + A purposive sample of 52 participants participated in 11 online racially/ethnically homogeneous focus groups conducted throughout the USA. A team consensus approach was utilized with codebook development and thematic analysis. + The findings relate to personal perceptions and interactions related to race and ethnicity, methods of protection against racism, vigilant behavior based on safety concerns, and unity across people of color. A few unique concerns by group included experiences of racism including physical violence among Asian American Pacific Islander groups, police brutality among Black groups, immigration discrimination in Latina groups, and religious discrimination in Middle Eastern groups. Changes in behavior for safety and protection include altering methods of transportation, teaching their children safety measures, and defending their immigration status. They shared strategies to help racial and ethnic minorities against racism including mental health resources and greater political representation. All racial and ethnic groups discussed the need for unity, solidarity, and allyship across various communities of color but for it to be authentic and long-lasting. + Greater understanding of the types of racism specific groups experience can inform policies and cultural change to reduce those factors. + © 2023. W. Montague Cobb-NMA Health Institute. + + + + Criss + Shaniece + S + + Department of Health Sciences, Furman University, Greenville, SC, 29613, USA. shaniece.criss@furman.edu. + + + + Kim + Melanie + M + + Department of Anthropology, Brown University, Providence, RI, 02912, USA. + + + + De La Cruz + Monica M + MM + + School of Social Welfare, University of California, Berkeley, CA, 94720, USA. + + + + Thai + Nhung + N + + Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA, 94720, USA. + + + + Nguyen + Quynh C + QC + + Department of Epidemiology & Biostatistics, School of Public Health, University of Maryland, College Park, MD, 20742, USA. + + + + Hswen + Yulin + Y + + Department of Epidemiology and Biostatistics, Bakar Computational Health Sciences Institute, University of California San Francisco, San Francisco, USA. + + + + Gee + Gilbert C + GC + + Department of Community Health Sciences, University of California, Los Angeles, CA, 90095, USA. + + + + Nguyen + Thu T + TT + + Department of Epidemiology & Biostatistics, School of Public Health, University of Maryland, College Park, MD, 20742, USA. + + + + eng + + + R00MD012615 + MD + NIMHD NIH HHS + United States + + + R01MD015716 + MD + NIMHD NIH HHS + United States + + + R01MD016037 + MD + NIMHD NIH HHS + United States + + + R01LM012849 + U.S. National Library of Medicine + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + Switzerland + J Racial Ethn Health Disparities + 101628476 + 2196-8837 + + IM + + Asian American and Pacific Islander + Black + Coping + Latina + Middle Eastern + Racism + Women + +
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+ + 1873-4626 + + + 2023 + Mar + 14 + + + Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract + J Gastrointest Surg + + Short-Term and Textbook Surgical Outcomes During the Implementation of a Robotic Gastrectomy Program. + 10.1007/s11605-023-05627-7 + + Whether gastric cancer patients derive greater benefit from robotic gastrectomy (RG), or open gastrectomy (OG) is unknown. We initiated a RG program in 2018, with prospective short-term outcome monitoring to ensure safety. We hypothesized that the RG program for gastric cancer can be safely implemented with equivalent safety and oncological textbook outcomes (TOs) to conventional open gastrectomy (OG). + The study included patients who underwent curative-intent OG or RG for gastric adenocarcinoma between January 2018 and December 2021. TO metrics were negative surgical margins, ≥ 15 lymph nodes examined, no severe (Clavien-Dindo grade ≥ IIIa) postoperative complications, no reinterventions within 90 days after surgery, no ICU admission, no prolonged length of stay (LOS; > 10 days), no 90-day postoperative mortality, and no readmission within 90 days after surgery. Overall TO was achieved when all these metrics were met. + Of 161 patients, 120 underwent OG, and 41 underwent RG. The two groups' demographic and disease characteristics did not differ significantly. Compared with OG patients, RG patients had a longer median surgery time (348 vs. 282 min), smaller median blood loss volume (50 vs. 150 mL), lower mean prescribed opioid dose at discharge (12 vs. 45 mg), and shorter median LOS (4 vs. 7 days; all p < 0.001). The groups' postoperative complication rates (10% vs. 17%) did not differ significantly (p = 0.283). The overall TO rate of the RG group (73%) was higher than that of the OG group (60%), but the difference was not significant (p = 0.131). + We were able to implement the RG program safely, without compromising safety or oncological outcomes. + © 2023. The Society for Surgery of the Alimentary Tract. + + + + Hirata + Yuki + Y + + Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Houston, TX, 77030, USA. + + + + Agnes + Annamaria + A + + Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Houston, TX, 77030, USA. + + + + Arvide + Elsa M + EM + + Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Houston, TX, 77030, USA. + + + + Robinson + Kristen A + KA + + Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Houston, TX, 77030, USA. + + + + To + Connie + C + + Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Houston, TX, 77030, USA. + + + + Griffith + Heather L + HL + + Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Houston, TX, 77030, USA. + + + + LaRose + Madison D + MD + + Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Houston, TX, 77030, USA. + + + + Munder + Kathryn M + KM + + Department of Clinical Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. + + + + Mansfield + Paul + P + + Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Houston, TX, 77030, USA. + + + + Badgwell + Brian D + BD + + Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Houston, TX, 77030, USA. + + + + Ikoma + Naruhiko + N + http://orcid.org/0000-0002-9825-9234 + + Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Houston, TX, 77030, USA. nikoma@mdanderson.org. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + J Gastrointest Surg + 9706084 + 1091-255X + + IM + + Robotic gastrectomy + Short-term outcomes + Textbook outcomes + +
+ + + + 2022 + 12 + 09 + + + 2023 + 01 + 28 + + + 2023 + 3 + 14 + 12 + 20 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917404 + 10.1007/s11605-023-05627-7 + 10.1007/s11605-023-05627-7 + + + + Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018; 68(6):394-424. + + 10.3322/caac.21492 + 30207593 + + + + Cunningham D, Allum WH, Stenning SP, Thompson JN, Van de Velde CJ, Nicolson M, Scarffe JH, Lofts FJ, Falk SJ, Iveson TJ, Smith DB, Langley RE, Verma M, Weeden S, Chua YJ, Participants MT. Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. 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Ann Surg Oncol 2021; 28(2):742-750. + + 10.1245/s10434-020-08834-7 + 32656721 + + + + Suda K, Yamamoto H, Nishigori T, Obama K, Yoda Y, Hikage M, Shibasaki S, Tanaka T, Kakeji Y, Inomata M, Kitagawa Y, Miyata H, Terashima M, Noshiro H, Uyama I. Safe implementation of robotic gastrectomy for gastric cancer under the requirements for universal health insurance coverage: a retrospective cohort study using a nationwide registry database in Japan. Gastric Cancer 2022; 25(2):438-449. + + 10.1007/s10120-021-01257-7 + 34637042 + + + + Ribeiro U, Jr., Dias AR, Ramos M, Yagi OK, Oliveira RJ, Pereira MA, Abdalla RZ, Zilberstein B, Nahas SC, Cecconello I. Short-Term Surgical Outcomes of Robotic Gastrectomy Compared to Open Gastrectomy for Patients with Gastric Cancer: a Randomized Trial. 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+ + + 36917395 + + 2023 + 03 + 14 + +
+ + 1534-6277 + + + 2023 + Mar + 14 + + + Current treatment options in oncology + Curr Treat Options Oncol + + Clinical Application of Artificial Intelligence for Non-melanoma Skin Cancer. + 10.1007/s11864-023-01065-4 + + The development and implementation of artificial intelligence is beginning to impact the care of dermatology patients. Although the clinical application of AI in dermatology to date has largely focused on melanoma, the prevalence of non-melanoma skin cancers, including basal cell and squamous cell cancers, is a critical application for this technology. The need for a timely diagnosis and treatment of skin cancers makes finding more time efficient diagnostic methods a top priority, and AI may help improve dermatologists' performance and facilitate care in the absence of dermatology expertise. Beyond diagnosis, for more severe cases, AI may help in predicting therapeutic response and replacing or reinforcing input from multidisciplinary teams. AI may also help in designing novel therapeutics. Despite this potential, enthusiasm in AI must be tempered by realistic expectations regarding performance. AI can only perform as well as the information that is used to train it, and development and implementation of new guidelines to improve transparency around training and performance of algorithms is key for promoting confidence in new systems. Special emphasis should be placed on the role of dermatologists in curating high-quality datasets that reflect a range of skin tones, diagnoses, and clinical scenarios. For ultimate success, dermatologists must not be wary of AI as a potential replacement for their expertise, but as a new tool to complement their diagnostic acumen and extend patient care. + © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. + + + + Sanchez + Katherine + K + + Lake Erie College of Osteopathic Medicine, Erie, PA, USA. + + + Department of Dermatology, Brigham and Women's Hospital, 221 Longwood Ave, Boston, MA, 02115, USA. + + + + Kamal + Kanika + K + + Department of Dermatology, Brigham and Women's Hospital, 221 Longwood Ave, Boston, MA, 02115, USA. + + + Harvard Medical School, Boston, MA, 02115, USA. + + + + Manjaly + Priya + P + + Department of Dermatology, Brigham and Women's Hospital, 221 Longwood Ave, Boston, MA, 02115, USA. + + + Boston University School of Medicine, Boston, USA. + + + + Ly + Sophia + S + + Department of Dermatology, Brigham and Women's Hospital, 221 Longwood Ave, Boston, MA, 02115, USA. + + + College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, US, USA. + + + + Mostaghimi + Arash + A + http://orcid.org/0000-0002-6084-5617 + + Department of Dermatology, Brigham and Women's Hospital, 221 Longwood Ave, Boston, MA, 02115, USA. amostaghimi@bwh.harvard.edu. + + + Harvard Medical School, Boston, MA, 02115, USA. amostaghimi@bwh.harvard.edu. + + + + eng + + Journal Article + Review + + + 2023 + 03 + 14 + +
+ + United States + Curr Treat Options Oncol + 100900946 + 1534-6277 + + IM + + Artificial intelligence + Artificial intelligence guidelines + Dermatology + Diversity and inclusion + Non-melanoma skin cancer + +
+ + + + 2023 + 01 + 26 + + + 2023 + 3 + 14 + 12 + 20 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917395 + 10.1007/s11864-023-01065-4 + 10.1007/s11864-023-01065-4 + + + References and Recommended Reading + + Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance + + Hauser K, Kurz A, Haggenmüller S, et al. Explainable artificial intelligence in skin cancer recognition: a systematic review. Eur J Cancer. 2022;167:54–69. https://doi.org/10.1016/j.ejca.2022.02.025 . + + 10.1016/j.ejca.2022.02.025 + 35390650 + + + + Hu W, Fang L, Ni R, Zhang H, Pan G. Changing trends in the disease burden of non-melanoma skin cancer globally from 1990 to 2019 and its predicted level in 25 years. BMC Cancer. 2022. https://doi.org/10.1186/s12885-022-09940-3 . + + 10.1186/s12885-022-09940-3 + 36572856 + 9793567 + + + + Jiang A, Jefferson IS, Robinson SK, et al. Skin cancer discovery during total body skin examinations. International Journal of Women’s Dermatology. 2021;7:411–4. https://doi.org/10.1016/j.ijwd.2021.05.005 . + + 10.1016/j.ijwd.2021.05.005 + 34621952 + 8484974 + + + + Asseri AH, Alam MJ, Alzahrani F, et al. Toward the identification of natural antiviral drug candidates against Merkel cell polyomavirus: Computational Drug Design Approaches. Pharmaceuticals (Basel). 2022;15:501. https://doi.org/10.3390/ph15050501 . + + 10.3390/ph15050501 + 35631328 + + + + •• Felmingham C, MacNamara S, Cranwell W, et al. Improving skin cancer management with artificial intelligence (SMARTI): Protocol for a preintervention/postintervention trial of an artificial intelligence system used as a diagnostic aid for skin cancer management in a specialist dermatology setting. BMJ Open. 2022. https://doi.org/10.1136/bmjopen-2021-050203 . 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Patient perspectives on the use of artificial intelligence for skin cancer screening. JAMA Dermatol. 2020;156:501. https://doi.org/10.1001/jamadermatol.2019.5014 . + + 10.1001/jamadermatol.2019.5014 + 32159733 + + + + Higgins S, Nazemi A, Chow M, Wysong A. Review of nonmelanoma skin cancer in African Americans, Hispanics, and Asians. Dermatol Surg. 2018;44:903–10. https://doi.org/10.1097/DSS.0000000000001547 . + + 10.1097/DSS.0000000000001547 + 29746428 + + + + Willingham ML, Spencer SYPK, Lum CA, Navarro Sanchez JM, Burnett T, Shepherd J, Cassel K. The potential of using artificial intelligence to improve skin cancer diagnoses in Hawai‘i’s multiethnic population. Melanoma Res. 2021;31:504–14. https://doi.org/10.1097/CMR.0000000000000779 . + + 10.1097/CMR.0000000000000779 + 34744150 + 8580213 + + + + • Guo LN, Lee MS, Kassamali B, Mita C, Nambudiri VE. Bias in, Bias Out: Underreporting and underrepresentation of diverse skin types in machine learning research for skin cancer detection—a scoping review. J Am Acad Dermatol. 2021;87:157–9. https://doi.org/10.1016/j.jaad.2021.06.884 . Although AI is still nascent in its development, issues regarding bias can profoundly impact performance and confound further improvements, as this study highlights. + + + Aggarwal P, Papay FA. Artificial intelligence image recognition of melanoma and basal cell carcinoma in racially diverse populations. J Dermatol Treat. 2021;33:2257–62. https://doi.org/10.1080/09546634.2021.1944970 . + + 10.1080/09546634.2021.1944970 + + + + Meena J, Hasija Y. Application of explainable artificial intelligence in the identification of squamous cell carcinoma biomarkers. Elsevier Computers in Biology and Medicine. 2022;146:105505. https://doi.org/10.1016/j.compbiomed.2022.105505 . + + 10.1016/j.compbiomed.2022.105505 + + + + Takiddin A, Schneider J, Yang Y, Abd-Alrazaq A, Househ M. Artificial intelligence for skin cancer detection: scoping review. J Med Internet Res. 2021. https://doi.org/10.2196/22934 . + + 10.2196/22934 + 34821566 + 8663507 + + + + •• Zakhem GA, Fakhoury JW, Motosko CC, Ho RS. Characterizing the role of dermatologists in developing artificial intelligence for assessment of skin cancer. J Am Acad Dermatol. 2021;85:1544–56. https://doi.org/10.1016/j.jaad.2020.01.028 . (The concern for onboarding more dermatologists for AI use and development is explicitly stated in this article. Their study explores the quality of AI algorithms developed by dermatologists for skin cancer assessment as opposed to other professionals not in the field.) + + 10.1016/j.jaad.2020.01.028 + 31972254 + + + + + +
+ + + 36917402 + + 2023 + 03 + 14 + +
+ + 1559-0305 + + + 2023 + Mar + 14 + + + Molecular biotechnology + Mol Biotechnol + + miR-139-3p/Wnt5A Axis Inhibits Metastasis in Hepatoblastoma. + 10.1007/s12033-023-00714-1 + + In order to examine new potential treatment options for the treatment of hepatoblastoma (HB), we identified the differential expression of five-candidate tumor suppressor miRNAs in HB and explored possible regulatory mechanisms of target miRNA molecule. By using real-time quantitative polymerase chain reaction (qPCR), we examined the expression of miRNAs in HB tissues and cells. The effect of has-miR-139-3p mimics on the invasion and migration ability was assessed by transwell assay and scratch-wound assay in HepG2 cells. Subsequently, we analyzed the target genes of miR-139-3p and their enrichment signaling pathways through bioinformatics. qPCR, Western-blot and dual-luciferase assays were further used to assess whether has-miR-139-3p targets Wnt5A. The results showed that hsa-miR-139-3p was significantly decreased in HB cells. Upregulation of hsa-miR-139-3p inhibited the invasive and migratory ability of HepG2. Bioinformatics analysis showed that hsa-miR-139-3p may target Wnt5A to regulate the WNT pathway, which was further confirmed by Western-blot and dual-luciferase assays. Overexpression of Wnt5A can reverse the miR-139-3p mimic-induced declines in the expression of WNT pathway-related proteins and restore the invasion and migration of HepG2. These data indicated that the hsa-miR-139-3p/Wnt5A axis inhibited HB metastasis, suggesting that miR-139-3p and Wnt5A may be potential targets for the treatment of HB. + © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. + + + + Wu + Zhouguang + Z + + Department of General Surgery, Shenzhen Children's Hospital, Yitian Road 7019, Shenzhen, 518000, Guangdong, China. + + + + Chen + Siqi + S + + Department of General Surgery, Shenzhen Children's Hospital, Yitian Road 7019, Shenzhen, 518000, Guangdong, China. + + + + Zuo + Taoyan + T + + Department of General Surgery, Shenzhen Children's Hospital, Yitian Road 7019, Shenzhen, 518000, Guangdong, China. + + + + Fu + Jingru + J + + Department of General Surgery, Shenzhen Children's Hospital, Yitian Road 7019, Shenzhen, 518000, Guangdong, China. + + + + Gong + Jiafeng + J + + Department of General Surgery, Shenzhen Children's Hospital, Yitian Road 7019, Shenzhen, 518000, Guangdong, China. + + + + Liu + Dong + D + + Department of General Surgery, Shenzhen Children's Hospital, Yitian Road 7019, Shenzhen, 518000, Guangdong, China. + + + + Wang + Bin + B + http://orcid.org/0000-0002-0951-4652 + + Department of General Surgery, Shenzhen Children's Hospital, Yitian Road 7019, Shenzhen, 518000, Guangdong, China. szwb1967@126.com. + + + + eng + + + SZSM201812055 + Sanming Project of Medicine in Shenzhen + + + + YX2019-03-02 + Research topic on the application of legal education system in the training of medical graduate students + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Mol Biotechnol + 9423533 + 1073-6085 + + IM + + Hepatoblastoma + Hsa-miR-139-3p + Wnt pathway + +
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Wnt 5a signaling is critical for macrophage-induced invasion of breast cancer cell lines. Proceedings of the National Academy of Sciences of the USA, 103(14), 5454–5459. + + 10.1073/pnas.0509703103 + 16569699 + 1459376 + + + + Huo, L., Wang, Y., Bai, X., Zheng, H., & Wang, M. (2020). circKIF4A promotes tumorogenesis of glioma by targeting miR-139-3p to activate Wnt5a signaling. Molecular Medicine (Cambridge, MA)., 26(1), 29. + + 10.1186/s10020-020-00159-1 + 7144061 + + + + +
+ + + 36917401 + + 2023 + 03 + 14 + +
+ + 1618-1255 + + + 2023 + Mar + 14 + + + Odontology + Odontology + + The effect of different kinematics on apical debris extrusion with a single-file system. + 10.1007/s10266-023-00802-3 + + To compare the amount of extruded debris caused by different motions using a single-file system. Fifty mandibular first molar teeth were randomized into 5 groups (n = 10) according to the motion tested: Optimize Torque Reverse (OTR), TF Adaptive Motion (TFA), continuous rotation (CR), reciprocation motion (+ 150°, -30°) (REC), and Jeni motion (Jeni). One Curve single file 25/06 (Micro-Mega, Besançon, France) was used in all experimental groups. The root canals were irrigated with 2.5% NaOCl, and the extruded debris were collected at pre-weighted glass vials. The glass vials were kept inside an incubator for one week at 70 °C to dry out the irrigating solution. The extruded debris was quantified by subtracting the pre-instrumentation from the post-instrumentation weight of the glass vials. The time required for each instrumentation procedure was digitally recorded. All data were analyzed statistically with one way ANOVA and post hoc Tukey test (P < 0.05). All the motions extruded apically debris with Jeni mode caused significantly less debris extrusion than TFA, REC, and CR (P < 0.05) while no significant difference emerged with OTR. Preparation time was not significantly different in all groups. Within the limits of the present study, all the kinematics produced apically debris extrusion, with Jeni reporting a similar amount of debris compared with OTR and significantly less than TFA, REC, and CR. Preparation time was similar among the tested kinematics. + © 2023. The Author(s). + + + + Al Omari + Taher M N + TMN + + Department of Conservative Dentistry, Faculty of Dentistry, Jordan University of Science and Technology, Irbid, Jordan. + + + + La Rosa + Giusy Rita Maria + GRM + http://orcid.org/0000-0001-5127-5299 + + Department of General Surgery and Medical-Surgical Specialties, University of Catania, Catania, Italy. g_larosa92@live.it. + + + + Albanna + Rami Haitham Issa + RHI + + Department of Conservative Dentistry, Faculty of Dentistry, Jordan University of Science and Technology, Irbid, Jordan. + + + + Tabnjh + Abedelmalek + A + + Department of Applied Dental Science, Faculty of Applied Medical Science, Jordan University of Science and Technology, Irbid, Jordan. + + + + Papale + Flavia + F + + Department of General Surgery and Medical-Surgical Specialties, University of Catania, Catania, Italy. + + + + Pedullà + Eugenio + E + + Department of General Surgery and Medical-Surgical Specialties, University of Catania, Catania, Italy. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Japan + Odontology + 101134822 + 1618-1247 + + IM + + Adaptive motion + Canal pro Jeni + Debris extrusion + One Curve + Optimum Torque Reverse + +
+ + + + 2022 + 12 + 15 + + + 2023 + 02 + 27 + + + 2023 + 3 + 14 + 12 + 20 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917401 + 10.1007/s10266-023-00802-3 + 10.1007/s10266-023-00802-3 + + + + Al Omari T, El-Farraj H, Arıcan B, Atav AA. Apical debris extrusion of full-sequenced rotary systems in narrow ribbon-shaped canals. Aust Endod J. 2022;48:245–50. + + 10.1111/aej.12540 + 34125465 + + + + PredinDjuric N, Van Der Vyver P, Vorster M, Vally ZI. Comparison of apical debris extrusion using clockwise and counter-clockwise single-file reciprocation of rotary and reciprocating systems. Aust Endod J. 2021;47:394–400. + + 10.1111/aej.12490 + + + + Ferraz CC, Gomes NV, Gomes BP, Zaia AA, Teixeira FB, Souza-Filho FJ. Apical extrusion of debris and irrigants using two hand and three engine-driven instrumentation techniques. Int Endod J. 2001;34:354–8. + + 10.1046/j.1365-2591.2001.00394.x + 11482718 + + + + Tinaz AC, Alacam T, Uzun O, Maden M, Kayaoglu G. 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Effects of the endodontic access cavity on apical debris extrusion during root canal preparation using different single-file systems. Restor Dent Endod. 2020;45: e33. + + 10.5395/rde.2020.45.e33 + 32839714 + 7431936 + + + + Kharouf N, Pedullà E, Nehme W, Akarma K, Mercey A, Gros CI, et al. Apically extruded debris in curved root canals using a new reciprocating single-file shaping system. J Endod. 2022;48:117–22. + + 10.1016/j.joen.2021.10.002 + 34699902 + + + + Tanalp J. A critical analysis of research methods and experimental models to study apical extrusion of debris and irrigants. Int Endod J. 2022;55(Suppl 1):153–77. + + 10.1111/iej.13686 + 35060142 + + + + Lu Y, Wang R, Zhang L, Li HL, Zheng QH, Zhou XD, et al. Apically extruded debris and irrigant with two Ni-Ti systems and hand files when removing root fillings: a laboratory study. Int Endod J. 2013;46:1125–30. + + 10.1111/iej.12104 + 23566178 + + + + Koçak S, Koçak MM, Sağlam BC, Türker SA, Sağsen B, Er Ö. 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Clin Oral Investig. 2015;19:357–61. + + 10.1007/s00784-014-1267-5 + 24950606 + + + + Kirchhoff AL, Fariniuk LF, Mello I. Apical extrusion of debris in flat-oval root canals after using different instrumentation systems. J Endod. 2015;41:237–41. + + 10.1016/j.joen.2014.09.023 + 25447504 + + + + Karataş E, Arslan H, Kırıcı D, Alsancak M, Çapar ID. Quantitative evaluation of apically extruded debris with Twisted File Adaptive instruments in straight root canals: reciprocation with different angles, adaptive motion and continuous rotation. Int Endod J. 2016;49:382–5. + + 10.1111/iej.12461 + 25944356 + + + + Boijink D, Costa DD, Hoppe CB, Kopper PMP, Grecca FS. Apically extruded debris in curved root canals using the waveone gold reciprocating and twisted file adaptive systems. J Endod. 2018;44:1289–92. + + 10.1016/j.joen.2018.04.011 + 29908692 + + + + Panchal V, Jeevanandan G, Subramanian EMG. Comparison of instrumentation time and obturation quality between hand K-file, H-files, and rotary Kedo-S in root canal treatment of primary teeth: a randomized controlled trial. J Indian Soc Pedod Prev Dent. 2019;37:75–9. + + 10.4103/JISPPD.JISPPD_72_18 + 30804311 + + + + +
+ + + 36917398 + + 2023 + 03 + 14 + +
+ + 1573-7322 + + + 2023 + Mar + 14 + + + Heart failure reviews + Heart Fail Rev + + The genetic basis for adult-onset idiopathic dilated cardiomyopathy in people of African descent. + 10.1007/s10741-023-10302-9 + + Cardiomyopathies are a heterogeneous group of cardiac muscle disorders that result in dilated, hypertrophic, or restrictive pathophysiological entities. Dilated cardiomyopathy (DCM) is the most common form in sub-Saharan Africa (SSA). However, population-specific research studies reporting the actual burden of DCM in this region are still lacking. Also, little is known about the genetic basis of DCM in this population, and genetic testing is still not readily accessible. This review describes the common pathogenic genes implicated in DCM globally and discusses the evidence-based management of patients with DCM. We also present a summary of studies describing genes implicated or associated with DCM in patients residing in SSA. + © 2023. The Author(s). + + + + Tsabedze + Nqoba + N + http://orcid.org/0000-0002-7210-1447 + + Division of Cardiology, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Charlotte Maxeke Johannesburg Academic Hospital, 17 Jubilee Road, Parktown, Johannesburg, Gauteng, 2193, South Africa. Nqoba.Tsabedze@wits.ac.za. + + + + Ramsay + Michele + M + http://orcid.org/0000-0002-4156-4801 + + Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. + + + + Krause + Amanda + A + http://orcid.org/0000-0002-7157-0807 + + Division of Human Genetics, National Health Laboratory Services and School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 2001, South Africa. + + + + Wells + Quinn + Q + http://orcid.org/0000-0003-3899-0313 + + Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, 37232, TN, USA. + + + + Mpanya + Dineo + D + http://orcid.org/0000-0003-3769-4686 + + Division of Cardiology, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Charlotte Maxeke Johannesburg Academic Hospital, 17 Jubilee Road, Parktown, Johannesburg, Gauteng, 2193, South Africa. + + + + Manga + Pravin + P + http://orcid.org/0000-0002-2709-2158 + + Division of Cardiology, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Charlotte Maxeke Johannesburg Academic Hospital, 17 Jubilee Road, Parktown, Johannesburg, Gauteng, 2193, South Africa. + + + + eng + + + B8749.RO1 + Carnegie Corporation of New York + + + + + Journal Article + Review + + + 2023 + 03 + 14 + +
+ + United States + Heart Fail Rev + 9612481 + 1382-4147 + + IM + + Familial dilated cardiomyopathy + Genetics + Heart failure + Idiopathic dilated cardiomyopathy + Monogenic + Sub-Saharan Africa + +
+ + + + 2023 + 02 + 15 + + + 2023 + 3 + 14 + 12 + 20 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917398 + 10.1007/s10741-023-10302-9 + 10.1007/s10741-023-10302-9 + + + + Agbor VN, Essouma M, Ntusi NaB, Nyaga UF, Bigna JJ, Noubiap JJ (2018) Heart failure in sub-Saharan Africa: a contemporaneous systematic review and meta-analysis. Int J Cardiol 257. https://doi.org/10.1016/j.ijcard.2017.12.048 + + + Steenekamp JH, Simson IW, Theron W (1992) Cardiovascular causes of death at Tshepong Hospital in 1 year, 1989–1990. A necropsy study. S Afr Med J 81(3) + + + Stewart S, Carrington M, Pretorius S, Methusi P, Sliwa K (2011) Standing at the crossroads between new and historically prevalent heart disease: effects of migration and socio-economic factors in the Heart of Soweto cohort study. Eur Heart J 32(4).  https://doi.org/10.1093/eurheartj/ehq439 + + + Dokainish H, Teo K, Zhu J, Roy A, Alhabib KF, Elsayed A et al (2013) Heart failure in Africa, Asia, the Middle East and South America: the INTER-CHF study. Int J Cardiol 204. https://doi.org/10.1016/j.ijcard.2015.11.183 + + + Callender T, Woodward M, Roth G, Farzadfar F, Lemarie JC, Gicquel S et al (2014) Heart failure care in low- and middle-income countries: a systematic review and meta-analysis. PLoS Med 11(8). https://doi.org/10.1371/journal.pmed.1001699 + + + Elliott P, Andersson B, Arbustini E, Bilinska Z, Cecchi F, Charron P et al (2008) Classification of the cardiomyopathies: a position statement from the European Society Of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur Heart J 29(2). https://doi.org/10.1093/eurheartj/ehm342 + + + Fatkin D, Johnson R, Mcgaughran J, Weintraub RG, Atherton JJ, Group CGCW (2017) Position statement on the diagnosis and management of familial dilated cardiomyopathy. Heart Lung Circ 26(11). https://doi.org/10.1016/j.hlc.2017.04.021 + + + Rosenbaum AN, Agre KE, Pereira NL (2020) Genetics of dilated cardiomyopathy: practical implications for heart failure management. Nat Rev Cardiol 17(5). https://doi.org/10.1038/s41569-019-0284-0 + + + Jordan E, Peterson L, Ai T, Asatryan B, Bronicki L, Brown E et al (2021) Evidence-based assessment of genes in dilated cardiomyopathy. Circulation 144(1). https://doi.org/10.1161/CIRCULATIONAHA.120.053033 + + + Tayal U, Ware JS, Lakdawala NK, Heymans S, Prasad SK (2021) Understanding the genetics of adult-onset dilated cardiomyopathy: what a clinician needs to know. Eur Heart J 42(24). https://doi.org/10.1093/eurheartj/ehab286 + + + Schultheiss HP, Fairweather D, Caforio ALP, Escher F, Hershberger RE, Lipshultz SE et al  (2019) Dilated cardiomyopathy. Nat Rev Dis Primers 5(1). https://doi.org/10.1038/s41572-019-0084-1 + + + Shaboodien G, Spracklen TF, Kamuli S, Ndibangwi P, Van Niekerk C, Ntusi NaB (2020) Genetics of inherited cardiomyopathies in Africa. Cardiovascular diagnosis and therapy 10(2). https://doi.org/10.21037/cdt.2019.10.03 + + + Mcnally EM, Mestroni L. Dilated cardiomyopathy: genetic determinants and mechanisms. Circ Res. 2017;121(7). https://doi.org/10.1161/CIRCRESAHA.116.309396 + + + Van Berlo JH, De Voogt WG, Van Der Kooi AJ, Van Tintelen JP, Bonne G, Yaou RB et al (2005) Meta-analysis of clinical characteristics of 299 carriers of LMNA gene mutations: do lamin A/C mutations portend a high risk of sudden death? J Mol Med (Berl) 83(1). https://doi.org/10.1007/s00109-004-0589-1 + + + Ciarambino T, Menna G, Sansone G, Giordano M (2021) Cardiomyopathies: an overview. Int J Mol Sci 22(14). https://doi.org/10.3390/ijms22147722 + + + Adadi N, Radi FZ, Lahrouchi N, Hara L, Ratbi I, Elalaoui SC et al (2018) Inherited dilated cardiomyopathy in a large Moroccan family caused by LMNA mutation. Anatol J Cardiol 20(1). https://doi.org/10.14744/AnatolJCardiol.2018.69639 + + + Fish M, Shaboodien G, Kraus S, Sliwa K, Seidman CE, Burke MA et al (2016) Mutation analysis of the phospholamban gene in 315 South Africans with dilated, hypertrophic, peripartum and arrhythmogenic right ventricular cardiomyopathies. Sci Rep 6. https://doi.org/10.1038/srep22235 + + + Sayed S, Idriss NK, Blann A, Sayyed HG, Raafat DM, Fouad D et al (2015) The number of GT(n) repeats in the hemeoxygenase-1 gene promoter is increased in pediatric heart failure but is unrelated to renal, antioxidant and anti-inflammatory markers. Pediatric cardiology 36(6). https://doi.org/10.1007/s00246-015-1146-0 + + + Mahjoub S, Mehri S, Ghazouani E, Ouarda F, Boussada R, Zaroui A et al (2010) HLA class II polymorphisms in Tunisian patients with dilated cardiomyopathy. Tissue Antigens 75(6). https://doi.org/10.1111/j.1399-0039.2009.01432.x + + + Mahjoub S, Mehri S, Ourda F, Boussaada R, Zouari B, Ben Arab S (2011) [Epidemiological study of the idiopathic dilated cardiomyopathy in Tunisia]. Ann Cardiol Angeiol (Paris) 60(4). https://doi.org/10.1016/j.ancard.2011.04.006 + + + Shaboodien G, Engel ME, Syed FF, Poulton J, Badri M, Mayosi BM (2009) The mitochondrial DNA T16189C polymorphism and HIV-associated cardiomyopathy: a genotype-phenotype association study. BMC Med Genet 10. https://doi.org/10.1186/1471-2350-10-37 + + + Du Preez J, Matolweni LO, Greenberg J, Mntla P, Adeyemo AA, Mayosi BM (2018) The α2CDel322–325 adrenergic receptor polymorphism is not associated with heart failure due to idiopathic dilated cardiomyopathy in black Africans + + + Woodiwiss AJ, Badenhorst D, Sliwa K, Brooksbank R, Essop R, Sareli P et al (2008) β1- and α2c-adrenoreceptor variants as predictors of clinical aspects of dilated cardiomyopathy in people of African ancestry + + + Badenhorst D, Norton GR, Sliwa K, Brooksbank R, Essop R, Sareli P et al (2007) Impact of beta2-adrenoreceptor gene variants on cardiac cavity size and systolic function in idiopathic dilated cardiomyopathy. Pharmacogenomics J 7(5). https://doi.org/10.1038/sj.tpj.6500426 + + + Khogali SS, Mayosi BM, Beattie JM, Mckenna WJ, Watkins H, Poulton J (2001) A common mitochondrial DNA variant associated with susceptibility to dilated cardiomyopathy in two different populations. Lancet (London, England) 357(9264). https://doi.org/10.1016/S0140-6736(00)04422-6 + + + Candy GP, Skudicky D, Mueller UK, Woodiwiss AJ, Sliwa K, Luker F et al (1999) Association of left ventricular systolic performance and cavity size with angiotensin-converting enzyme genotype in idiopathic dilated cardiomyopathy. The American journal of cardiology 83(5). https://doi.org/10.1016/s0002-9149(98)00981-3 + + + Tiago AD, Badenhorst D, Skudicky D, Woodiwiss AJ, Candy GP, Brooksbank R et al (2002) An aldosterone synthase gene variant is associated with improvement in left ventricular ejection fraction in dilated cardiomyopathy. Cardiovasc Res 54(3). https://doi.org/10.1016/s0008-6363(02)00281-x + + + Bailly C, Henriques S, Tsabedze N, Krause A (2019) Role of family history and clinical screening in the identification of families with idiopathic dilated cardiomyopathy in Johannesburg, South Africa. S Afr Med J 109(9). https://doi.org/10.7196/SAMJ.2019.v109i9.13936 + + + Brown CA, Lanning RW, Mckinney KQ, Salvino AR, Cherniske E, Crowe CA et al (2001) Novel and recurrent mutations in lamin A/C in patients with Emery-Dreifuss muscular dystrophy. Am J Med Genet 102(4). https://doi.org/10.1002/ajmg.1463 + + + Dec GW, Fuster V (1994) Idiopathic dilated cardiomyopathy. New England Journal of Medicine 331(23). https://doi.org/10.1056/NEJM199412083312307 + + + Lakdawala NK, Winterfield JR, Funke BH (2013) Dilated cardiomyopathy. Circ Arrhythm Electrophysiol 6(1). https://doi.org/10.1161/CIRCEP.111.962050 + + + Merlo M, Cannata A, Gobbo M, Stolfo D, Elliott PM, Sinagra G (2018) Evolving concepts in dilated cardiomyopathy. Eur J Heart Fail 20(2). https://doi.org/10.1002/ejhf.1103 + + + Japp AG, Gulati A, Cook SA, Cowie MR, Prasad SK (2016) The diagnosis and evaluation of dilated cardiomyopathy. J Am Coll Cardiol 67(25). https://doi.org/10.1016/j.jacc.2016.03.590 + + + Murtaza G, Virk HUH, Khalid M, Rahman Z, Sitwala P, Schoondyke J et al (2017) Role of speckle tracking echocardiography in dilated cardiomyopathy: a review. Cureus 9(6). https://doi.org/10.7759/cureus.1372 + + + Gardner RS, Ozalp F, Murday AJ, Robb SD, Mcdonagh TA (2003) N-terminal pro-brain natriuretic peptide. A new gold standard in predicting mortality in patients with advanced heart failure. Eur Heart J 24(19). https://doi.org/10.1016/j.ehj.2003.07.005 + + + Kim H, Cho YK, Jun DH, Nam CW, Han SW, Hur SH et al (2008) Prognostic implications of the NT-ProBNP level and left atrial size in non-ischemic dilated cardiomyopathy. Circ J 72(10). https://doi.org/10.1253/circj.cj-07-1087 + + + Mcdonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Bohm M et al (2021) 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J 42(36). https://doi.org/10.1093/eurheartj/ehab368 + + + Becker MaJ, Cornel JH, Van De Ven PM, Van Rossum AC, Allaart CP, Germans T (2018) The prognostic value of late gadolinium-enhanced cardiac magnetic resonance imaging in nonischemic dilated cardiomyopathy: a review and meta-analysis. JACC Cardiovasc Imaging 11(9). https://doi.org/10.1016/j.jcmg.2018.03.006 + + + Di Marco A, Anguera I, Schmitt M, Klem I, Neilan TG, White JA et al (2017) Late Gadolinium enhancement and the risk for ventricular arrhythmias or sudden death in dilated cardiomyopathy: systematic review and meta-analysis. JACC Heart Fail 5(1). https://doi.org/10.1016/j.jchf.2016.09.017 + + + Pi SH, Kim SM, Choi JO, Kim EK, Chang SA, Choe YH et al (2018) Prognostic value of myocardial strain and late gadolinium enhancement on cardiovascular magnetic resonance imaging in patients with idiopathic dilated cardiomyopathy with moderate to severely reduced ejection fraction. J Cardiovasc Magn Reson 20(1). https://doi.org/10.1186/s12968-018-0466-7 + + + Zhang K, Wang W, Zhao S, Katz SD, Iervasi G, Gerdes AM et al (2018) Long-term prognostic value of combined free triiodothyronine and late gadolinium enhancement in nonischemic dilated cardiomyopathy. Clin Cardiol 41(1). https://doi.org/10.1002/clc.22858 + + + Seferovic PM, Tsutsui H, Mcnamara DM, Ristic AD, Basso C, Bozkurt B et al (2021) Heart Failure Association, Heart Failure Society of America, and Japanese Heart Failure Society position statement on endomyocardial biopsy. J Card Fail 27(7). https://doi.org/10.1016/j.cardfail.2021.04.010 + + + Evans JP, Skrzynia C, Burke W (2001) The complexities of predictive genetic testing. BMJ 322(7293). https://doi.org/10.1136/bmj.322.7293.1052 + + + Hershberger RE, Givertz MM, Ho CY, Judge DP, Kantor PF, Mcbride KL et al (2018) Genetic evaluation of cardiomyopathy: a clinical practice resource of the American College of Medical Genetics and Genomics (ACMG). Genet Med 20(9). https://doi.org/10.1038/s41436-018-0039-z + + + Bozkurt B, Colvin M, Cook J, Cooper LT, Deswal A, Fonarow GC et al (2016) Current diagnostic and treatment strategies for specific dilated cardiomyopathies: a scientific statement from the American Heart Association. Circulation. 134(23). https://doi.org/10.1161/CIR.0000000000000455 + + + Ramchand J, Wallis M, Macciocca I, Lynch E, Farouque O, Martyn M et al (2020) Prospective evaluation of the utility of whole exome sequencing in dilated cardiomyopathy. J Am Heart Assoc 9(2). https://doi.org/10.1161/JAHA.119.013346 + + + Minoche AE, Horvat C, Johnson R, Gayevskiy V, Morton SU, Drew AP et al (2019) Genome sequencing as a first-line genetic test in familial dilated cardiomyopathy. Genet Med 21(3). https://doi.org/10.1038/s41436-018-0084-7 + + + Krause A (2019) New genetic testing technologies: advantages and limitations. S Afr Med J 109(4). https://doi.org/10.7196/SAMJ.2019.v109i4.13990 + + + Tschope C, Ammirati E, Bozkurt B, Caforio ALP, Cooper LT, Felix SB et al (2021) Myocarditis and inflammatory cardiomyopathy: current evidence and future directions. Nat Rev Cardiol 18(3). https://doi.org/10.1038/s41569-020-00435-x + + + Horne BD, Rasmusson KD, Alharethi R, Budge D, Brunisholz KD, Metz T et al (2011) Genome-wide significance and replication of the chromosome 12p11.22 locus near the PTHLH gene for peripartum cardiomyopathy. Circ Cardiovasc Genet 4(4). https://doi.org/10.1161/CIRCGENETICS.110.959205 + + + Morales A, Painter T, Li R, Siegfried JD, Li D, Norton N et al (2010) Rare variant mutations in pregnancy-associated or peripartum cardiomyopathy. Circulation 121(20). https://doi.org/10.1161/CIRCULATIONAHA.109.931220 + + + Sheppard R, Hsich E, Damp J, Elkayam U, Kealey A, Ramani G et al (2016) GNB3 C825T Polymorphism and myocardial recovery in peripartum cardiomyopathy: results of the multicenter investigations of pregnancy-associated cardiomyopathy study. Circ Heart Fail 9(3). https://doi.org/10.1161/CIRCHEARTFAILURE.115.002683 + + + Ware JS, Li J, Mazaika E, Yasso CM, Desouza T, Cappola TP et al (2016) Shared genetic predisposition in peripartum and dilated cardiomyopathies. N Engl J Med 374(3). https://doi.org/10.1056/NEJMoa1505517 + + + Goli R, Li J, Brandimarto J, Levine LD, Riis V, Mcafee Q et al (2021) Genetic and phenotypic landscape of peripartum cardiomyopathy. Circulation 143(19). https://doi.org/10.1161/CIRCULATIONAHA.120.052395 + + + Verdonschot JaJ, Hazebroek MR, Ware JS, Prasad SK, Heymans SRB (2019) Role of targeted therapy in dilated cardiomyopathy: the challenging road toward a personalized approach. J Am Heart Assoc 8(11). https://doi.org/10.1161/JAHA.119.012514 + + + Crasto S, My I, Di Pasquale E (2020) The Broad Spectrum of LMNA Cardiac diseases: from molecular mechanisms to clinical phenotype. Front Physiol 11. https://doi.org/10.3389/fphys.2020.00761 + + + Ollila L, Nikus K, Holmstrom M, Jalanko M, Jurkko R, Kaartinen M et al (2017) Clinical disease presentation and ECG characteristics of LMNA mutation carriers. Open Heart 4(1). https://doi.org/10.1136/openhrt-2016-000474 + + + Repetti GG, Toepfer CN, Seidman JG, Seidman CE (2019) Novel therapies for prevention and early treatment of cardiomyopathies. Circ Res 124(11). https://doi.org/10.1161/CIRCRESAHA.119.313569 + + + Pfizer (2021) A study of ARRY-371797 (PF-07265803) in patients with symptomatic dilated cardiomyopathy due to a lamin A/C gene mutation. Available from: https://www.pfizerclinicaltrials.com/find-a-trial/nct03439514 . + + + Kraus SM, Shaboodien G, Francis V, Laing N, Cirota J, Chin A et al (2021) Rationale and design of the African Cardiomyopathy and Myocarditis Registry Program: the IMHOTEP study. Int J Cardiol 333. https://doi.org/10.1016/j.ijcard.2021.02.026 + + + Peprah E, Wiley K, Sampson U, Narula J (2017) A New Age for African-Driven Genomics Research: Human Heredity and Health in Africa (H3Africa). Glob Heart 12(2). https://doi.org/10.1016/j.gheart.2017.05.003 + + + +
+ + + 36917400 + + 2023 + 03 + 14 + +
+ + 1618-1255 + + + 2023 + Mar + 14 + + + Odontology + Odontology + + TiO2 nanotube-based nanotechnology applied to high-viscosity conventional glass-ionomer cement: ultrastructural analyses and physicochemical characterization. + 10.1007/s10266-023-00799-9 + + This study characterized TiO2 nanotube (TiO2-nt) ultrastructure and morphology, and the physicochemical impact on high-viscosity conventional glass-ionomer cement (GIC). TiO2-nt was synthesized by the alkaline method (n = 3), assessed by scanning (SEM) and transmission electron microscope (TEM), and was added (3%, 5%, 7%-in weight) to KM (Ketac Molar EasyMix™). Analyses included: SEM; Energy-dispersive spectroscopy (EDS); Raman spectroscopy (RAMAN); Setting time with Gillmore needles (ST); Color (Co); Radiopacity (XR); Water sorption (WS); and solubility (SO). Quantitative data were submitted to ANOVA and Tukey's tests (chr = 0.05). External and internal TiO2-nt diameters were 11 ± 2 nm and 6 ± 0 nm, respectively. Data analyses showed: (i) TiO2-nt present into KM matrix, with a concentration-dependent increase of Ti levels into KM, (ii) physical interaction between KM and TiO2-nt, (iii) longer initial ST for the 7% group compared to KM and 3% groups (p ≤ 0.01), (iv) decreased luminosity and yellowness for the 5% and 7% groups, (v) 36% greater radiopacity for the 5% group compared to enamel, dentin, and KM, and (vi) lower SO values for the 5% group, with no significant differences on WS across the groups. TiO2-nt displayed physical interaction with KM matrix, and also modified SO, XR and Co, without affecting ST. This study provides information on the potential impact of TiO2-nt on GIC performance. TiO2-nt may be proposed to boost confidence among dental surgeons in terms of GIC's handling characteristics, success rate and differential diagnostic. + © 2023. The Author(s), under exclusive licence to The Society of The Nippon Dental University. + + + + Kantovitz + Kamila Rosamilia + KR + http://orcid.org/0000-0003-2045-7924 + + Faculdade São Leopoldo, SLMANDIC, Rua José Rocha Junqueira, 13, Campinas, SP, 13045-755, Brazil. kamila.kantovitz@slmandic.edu.br. + + + + Carlos + Natália Russo + NR + + Faculdade São Leopoldo, SLMANDIC, Rua José Rocha Junqueira, 13, Campinas, SP, 13045-755, Brazil. + + + + Silva + Ivania Aparecida Pimenta Santos + IAPS + + Faculdade São Leopoldo, SLMANDIC, Rua José Rocha Junqueira, 13, Campinas, SP, 13045-755, Brazil. + + + + Braido + Caroline + C + + Pediatric Division, Department of Health Sciences, Orthodontics and Pediatric Dentistry, Piracicaba Dental School, University of Campinas, UNICAMP, Piracicaba, SP, Brazil. + + + + Costa + Bruna Carolina + BC + + Department of Physics, School of Science, São Paulo State University, UNESP, Bauru, SP, Brazil. + + + + Kitagawa + Igor Lebedenco + IL + + Federal Institute of Education, Science and Technology of São Paulo, IFSP, Birigui, SP, Brazil. + + + + Nociti-Jr + Francisco Humberto + FH + + Faculdade São Leopoldo, SLMANDIC, Rua José Rocha Junqueira, 13, Campinas, SP, 13045-755, Brazil. + + + Division of Periodontics, Department of Prosthodontics and Periodontics, Piracicaba Dental School, University of Campinas, UNICAMP, Piracicaba, SP, Brazil. + + + + Basting + Roberta Tarkany + RT + + Faculdade São Leopoldo, SLMANDIC, Rua José Rocha Junqueira, 13, Campinas, SP, 13045-755, Brazil. + + + + de Figueiredo + Francine Kuhl Panzarella + FKP + + Faculdade São Leopoldo, SLMANDIC, Rua José Rocha Junqueira, 13, Campinas, SP, 13045-755, Brazil. + + + + Lisboa-Filho + Paulo Noronha + PN + + Department of Physics, School of Science, São Paulo State University, UNESP, Bauru, SP, Brazil. + + + + eng + + + ARP#2019/14078-8 + Fundação de Amparo à Pesquisa do Estado de São Paulo + + + + ARP#2016/13786-0 + Fundação de Amparo à Pesquisa do Estado de São Paulo + + + + PIBIC#2018-2019 + Conselho Nacional de Desenvolvimento Científico e Tecnológico + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + Japan + Odontology + 101134822 + 1618-1247 + + IM + + Glass ionomer cement + Morphological properties + Nanotechnology + Optical properties + Physical properties + Titanium + +
+ + + + 2022 + 04 + 05 + + + 2023 + 02 + 28 + + + 2023 + 3 + 14 + 12 + 20 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917400 + 10.1007/s10266-023-00799-9 + 10.1007/s10266-023-00799-9 + + + + Wilson AD, Kent BE. A new translucent cement for dentistry. The glass ionomer cement. Br Dent. 1972;132(4):133–5. https://doi.org/10.1038/sj.bdj.4802810 . + + 10.1038/sj.bdj.4802810 + + + + Anusavice KJ, Shen C, Rawls HR. Phillip’s science of dental materials. 12th ed. St. Louis: Elsevier; 2013. + + + Tonmukayakul U, Arrow P. Cost-effectiveness analysis of the atraumatic restorative treatment-based approach to managing early childhood caries. Community Dent Oral Epidemiol. 2017;45(1):92–100. https://doi.org/10.1111/cdoe.12265 . + + 10.1111/cdoe.12265 + 27859533 + + + + Mustafa HA, Soares AP, Paris S, Elhennawy K, Zaslansky P. The forgotten merits of GIC restorations: a systematic review. 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+ + 2366-1089 + + + 2023 + Mar + 14 + + + Oncology and therapy + Oncol Ther + + Immune Checkpoint Inhibitors in Breast Cancer: A Narrative Review. + 10.1007/s40487-023-00224-9 + + Breast cancer is the most frequently diagnosed malignancy in patients worldwide and the main cause of cancer-related death. Though still incurable, metastatic breast cancer's prognosis has been considerably improved in the past 10 years due to the introduction of new targeted agents, such as immune checkpoint inhibitors (ICI). However, these medications are associated with unique side effects known as immune-mediated adverse events (irAE). In this paper, we review the clinical evidence for the use of ICIs in breast cancer, in both the metastatic as well as neoadjuvant/adjuvant setting, followed by a review of irAE most commonly seen, and the medications used to treat them. Our opinion is that any cancer specialist treating patients with breast cancer should be aware of these side effects for early detection and management, and oncologists should be the leaders of the multidisciplinary team that will take care of them. + © 2023. The Author(s). + + + + Nunes Filho + Paulo + P + http://orcid.org/0000-0002-4314-9230 + + Labcorp Drug Development, Burlington, NC, USA. paulo.nunes@labcorp.com. + + + Rua Augusto Pestana, 25/92, Porto Alegre, RS, Brazil. paulo.nunes@labcorp.com. + + + + Albuquerque + Caroline + C + + Hospital São Lucas da PUCRS, Porto Alegre, Brazil. + + + + Pilon Capella + Mariana + M + + McGill University, Montreal, Canada. + + + + Debiasi + Marcio + M + + Breast Unit, Champalimaud Clinical Centre/Champalimaud Foundation, Lisbon, Portugal. + + + + eng + + Journal Article + Review + + + 2023 + 03 + 14 + +
+ + New Zealand + Oncol Ther + 101677510 + 2366-1089 + + + Breast neoplasms + Drug-related side effects and adverse reactions + Immune checkpoint inhibitors + Oncologists + Patient care team + +
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+ + + 36917403 + + 2023 + 03 + 14 + +
+ + 1873-4626 + + + 2023 + Mar + 14 + + + Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract + J Gastrointest Surg + + Tranditional Roux-en-Y vs Uncut Roux-en-Y in Laparoscopic Distal Gastrectomy: a Randomized Controlled Study. + 10.1007/s11605-023-05644-6 + + Traditional Roux-en-Y may cause Roux-en-Y stasis syndrome (RSS), and Uncut Roux-en-Y was proposed to solve this problem. However, because afferent loop recanalization may occur after surgery, its clinical application remains controversial. The purpose of this study was to compare the long-term outcomes of these two gastrointestinal reconstruction methods. + A total of 108 patients who received laparoscopic-assisted distal gastrectomy (LADG) were enrolled; 57 were randomly divided into the Uncut Roux-en-Y (URY) group, and 51 were divided into the Roux-en-Y (RY) group. Patients were followed up for 1 year to evaluate variables, including the following: (1) Assessments for RSS; (2) Preoperative and postoperative Gastrointestinal Symptom Rating Scale (GSRS) scores; (3) Postoperative gastroscopy to assess the occurrence of reflux esophagitis (Los Angeles classification), residual gastritis and bile reflux 1 year after surgery; and (4) Upper gastrointestinal radiography to evaluate whether recanalization occurred in patients in the URY group after surgery. + At 1 year after surgery, a total of 42 patients (73.7%) developed afferent loop recanalization. The incidence of RSS was not different between the two groups (OR, 1.301 [95% CI, 0.482 to 3.509]; P = 0.603P = 0.603). The GSRS score was higher in the URY group (P < 0.001). Postoperative gastroscopy showed that the incidence of bile reflux (P < 0.001) and the grade of residual gastritis (P < 0.001) were significantly higher in the URY group, but the grade of reflux esophagitis was not significantly different (P = 0.447, [95% CI, 0.437 to 0.457]P = 0.397). + Compared with traditional Roux-en-Y anastomosis, due to the high recanalization rate, the URY group developed more severe gastrointestinal symptoms, the incidence of bile reflux and the grade of residual gastritis increased and the incidence of postoperative RSS was not reduced. + © 2023. The Author(s). + + + + Xie + Huahao + H + + Department of General Surgery, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China. + + + + Wu + Feng + F + + Department of General Surgery, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China. + + + Department of General Surgery, Hwa Mei Hospital, University of Chinese Academy of Sciences, Zhejiang, China. + + + + Huang + Chenshen + C + + Department of General Surgery, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China. + + + Department of Gastrointestinal Surgery, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China. + + + + Chen + Quanning + Q + + Department of General Surgery, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China. + + + + Ni + Zhizhan + Z + + Department of General Surgery, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China. + + + + Wang + Song + S + + Department of General Surgery, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China. + + + + Ge + Bujun + B + + Department of General Surgery, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China. gebujun@126.com. + + + + Liu + Liming + L + + Department of General Surgery, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China. liu_liming755@126.com. + + + Department of General Surgery, Shanghai Jing'an Shibei Hospital, Shanghai, China. liu_liming755@126.com. + + + + Huang + Qi + Q + + Department of General Surgery, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China. hqhq0078@163.com. + + + + eng + + + No. ITJ (ZD) 1804 + Tongji Hospital + + + + No. 201840357 + Tongji Hospital + + + + SKW2038 + Tongji Hospital + + + + SKW1921 + Tongji Hospital + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + J Gastrointest Surg + 9706084 + 1091-255X + + IM +
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+ + + 36917407 + + 2023 + 03 + 14 + +
+ + 1869-1889 + + + 2023 + Mar + 10 + + + Science China. Life sciences + Sci China Life Sci + + Fine-tuning of quantitative traits. + 10.1007/s11427-023-2321-7 + + + Luo + Guangbin + G + + NovoCrops Centre, Department of Plant and Environmental Sciences, University of Copenhagen, 1871, Frederiksberg, Denmark. + + + + Palmgren + Michael + M + + NovoCrops Centre, Department of Plant and Environmental Sciences, University of Copenhagen, 1871, Frederiksberg, Denmark. palmgren@plen.ku.dk. + + + + eng + + Journal Article + + + 2023 + 03 + 10 + +
+ + China + Sci China Life Sci + 101529880 + 1674-7305 + + IM +
+ + + + 2023 + 03 + 10 + + + 2023 + 03 + 10 + + + 2023 + 3 + 14 + 12 + 20 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917407 + 10.1007/s11427-023-2321-7 + 10.1007/s11427-023-2321-7 + + + + Hinnebusch, A.G., Ivanov, I.P., and Sonenberg, N. (2016). Translational control by 5′-untranslated regions of eukaryotic mRNAs. Science 352, 1413–1416. + + 10.1126/science.aad9868 + 27313038 + 7422601 + + + + Morris, D.R., and Geballe, A.P. (2000). Upstream open reading frames as regulators of mRNA translation. Mol Cell Biol 20, 8635–8642. + + 10.1128/MCB.20.23.8635-8642.2000 + 11073965 + 86464 + + + + Rodríguez-Leal, D., Lemmon, Z.H., Man, J., Bartlett, M.E., and Lippman, Z.B. (2017). Engineering quantitative trait variation for crop improvement by genome editing. Cell 171, 470–480.e8. + + 10.1016/j.cell.2017.08.030 + 28919077 + + + + Ruiz-Orera, J., and Albà, M.M. (2019). Translation of small open reading frames: roles in regulation and evolutionary innovation. Trends Genet 35, 186–198. + + 10.1016/j.tig.2018.12.003 + 30606460 + + + + Si, X., Zhang, H., Wang, Y., Chen, K., and Gao, C. (2020). Manipulating gene translation in plants by CRISPR-Cas9-mediated genome editing of upstream open reading frames. Nat Protoc 15, 338–363. + + 10.1038/s41596-019-0238-3 + 31915386 + + + + Xing, S., Chen, K., Zhu, H., Zhang, R., Zhang, H., Li, B., and Gao, C. (2020). Fine-tuning sugar content in strawberry. Genome Biol 21, 230. + + 10.1186/s13059-020-02146-5 + 32883370 + 7470447 + + + + Xue, C., Qiu, F., Wang, Y., Li, B., Zhao, K., Chen, K., and Gao, C. (2023). Tuning plant phenotypes by precise, graded downregulation of gene expression. Nat Biotechnol doi: https://doi.org/10.1038/s41587-023-01707-w . + + + Zhang, H., Si, X., Ji, X., Fan, R., Liu, J., Chen, K., Wang, D., and Gao, C. (2018). Genome editing of upstream open reading frames enables translational control in plants. Nat Biotechnol 36, 894–898. + + 10.1038/nbt.4202 + 30080209 + + + + +
+ + + 36917406 + + 2023 + 03 + 14 + +
+ + 1869-1889 + + + 2023 + Mar + 09 + + + Science China. Life sciences + Sci China Life Sci + + Autophagy mediates a direct synergistic interaction during co-transmission of two distinct arboviruses by insect vectors. + 10.1007/s11427-022-2228-y + + Multiple viral infections in insect vectors with synergistic effects are common in nature, but the underlying mechanism remains elusive. Here, we find that rice gall dwarf reovirus (RGDV) facilitates the transmission of rice stripe mosaic rhabdovirus (RSMV) by co-infected leafhopper vectors. RSMV nucleoprotein (N) alone activates complete anti-viral autophagy, while RGDV nonstructural protein Pns11 alone induces pro-viral incomplete autophagy. In co-infected vectors, RSMV exploits Pns11-induced autophagosomes to assemble enveloped virions via N-Pns11-ATG5 interaction. Furthermore, RSMV could effectively propagate in Sf9 cells. Expression of Pns11 in Sf9 cells or leafhopper vectors causes the recruitment of N from the ER to Pns11-induced autophagosomes and inhibits N-induced complete autophagic flux, finally facilitating RSMV propagation. In summary, these results demonstrate a previously unappreciated role of autophagy in the regulation of the direct synergistic interaction during co-transmission of two distinct arboviruses by insect vectors and reveal the functional importance of virus-induced autophagosomes in rhabdovirus assembly. + © 2023. Science China Press. + + + + Jia + Dongsheng + D + + Vector-borne Virus Research Center, State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, Fujian Agriculture and Forestry University, Fuzhou, 350002, China. + + + + Liang + Qifu + Q + + Vector-borne Virus Research Center, State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, Fujian Agriculture and Forestry University, Fuzhou, 350002, China. + + + + Chen + Hongyan + H + + Vector-borne Virus Research Center, State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, Fujian Agriculture and Forestry University, Fuzhou, 350002, China. + + + + Liu + Huan + H + + Vector-borne Virus Research Center, State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, Fujian Agriculture and Forestry University, Fuzhou, 350002, China. + + + + Li + Guangjun + G + + Vector-borne Virus Research Center, State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, Fujian Agriculture and Forestry University, Fuzhou, 350002, China. + + + + Zhang + Xiaofeng + X + + Vector-borne Virus Research Center, State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, Fujian Agriculture and Forestry University, Fuzhou, 350002, China. + + + + Chen + Qian + Q + + Vector-borne Virus Research Center, State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, Fujian Agriculture and Forestry University, Fuzhou, 350002, China. + + + + Wang + Aiming + A + + London Research and Development Centre, Agriculture and Agri-Food Canada, London, Ontario, N5V 4T3, Canada. + + + + Wei + Taiyun + T + + Vector-borne Virus Research Center, State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, Fujian Agriculture and Forestry University, Fuzhou, 350002, China. weitaiyun@fafu.edu.cn. + + + + eng + + Journal Article + + + 2023 + 03 + 09 + +
+ + China + Sci China Life Sci + 101529880 + 1674-7305 + + IM + + autophagy + co-transmission + insect vector + rhabdovirus + synergistic interaction + +
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A plant reovirus hijacks endoplasmic reticulum-associated degradation machinery to promote efficient viral transmission by its planthopper vector under high temperature conditions. PLoS Pathog 17, e1009347. + + 33647067 + 7951979 + 10.1371/journal.ppat.1009347 + + + + Zhao, P., Sun, X., Li, P., Sun, J., Yue, Y., Wei, J., Wei, T., and Jia, D. (2019). Infection characteristics of Rice stripe mosaic virus in the body of the vector leafhoppers. Front Microbiol 9, 3258. + + 30671049 + 6331539 + 10.3389/fmicb.2018.03258 + + + + Zhang, X.F., Zeng, T., Xie, Y., Zheng, Y., Wang, H., Lin, H., Wang, Z., and Wei, T. (2021). Rice yellow stunt virus activates polyamine biosynthesis to promote viral propagation in insect vectors by disrupting ornithine decarboxylase antienzyme function. Sci China Life Sci 64, 1522–1532. + + 33452997 + 7811333 + 10.1007/s11427-020-1846-8 + + + + Zheng, L., Chen, H., Liu, H., Xie, L., and Wei, T. (2015). Assembly of viroplasms by viral nonstructural protein Pns9 is essential for persistent infection of rice gall dwarf virus in its insect vector. Virus Res 196, 162–169. + + 25455335 + 10.1016/j.virusres.2014.11.025 + + + + +
+ + + 36917408 + + 2023 + 03 + 14 + +
+ + 2730-7174 + + + 2023 + Mar + 14 + + + Research on child and adolescent psychopathology + Res Child Adolesc Psychopathol + + Antecedents and Consequences of Child Externalizing Problems: Differences in Dynamic Parent-Child Processes. + 10.1007/s10802-023-01045-0 + + Given that noncompliance is the most common externalizing problem during middle childhood and reliably predicts significant conduct problems, innovations in elucidating its etiology are sorely needed. Evaluation of in-the-moment antecedents and consequences of child noncompliance improves traction on this goal, given that multiple theories contend that child noncompliance and parent behavior mutually influence each other through negative reciprocation as well as contingent praise processes. Among a sample of 140 families (child age: 6-10 years; 32.1% female), the present study capitalized on intensive repeated measures of observed child noncompliance and parent negative talk and praise objectively coded during three unique tasks. We employed dynamic structural equation modeling to evaluate within-dyad parent-child behavioral dynamics and between-dyad differences therein. Results provided mixed support for hypotheses and suggested that antecedents and consequences of child noncompliance differed according to task demands and child ADHD symptoms. Contrary to models of coercive cycles, during child-led play, parent negative talk was more likely following prior child noncompliance, but child noncompliance was less likely following prior parent negative talk. As expected, during parent-led play, parent praise was less likely following prior child noncompliance, which was also less likely following prior parent praise. Relative to youth with fewer symptoms, for children with elevated ADHD symptoms, during a challenging clean-up task, child noncompliance was less stable and less contingent on prior parent negative talk. Results are discussed in terms of their implications of real-time parent-child interactions for typical and atypical development of externalizing problems. + © 2023. The Author(s). + + + + Somers + Jennifer A + JA + http://orcid.org/0000-0002-5334-0370 + + Department of Psychology, University of California, Los Angeles, USA. jsomers@psych.ucla.edu. + + + + Stiles + Kelsey + K + http://orcid.org/0000-0003-2771-4970 + + Department of Psychology, University of California, Los Angeles, USA. + + + + MacNaughton + Gabrielle A + GA + http://orcid.org/0000-0002-0454-7375 + + Department of Psychology, University of California, Los Angeles, USA. + + + + Schiff + Sara J + SJ + http://orcid.org/0000-0001-9745-7952 + + Department of Psychology, University of California, Los Angeles, USA. + + + + Shen + Yixuan + Y + + Department of Psychology, University of California, Los Angeles, USA. + + + + Lee + Steve S + SS + + Department of Psychology, University of California, Los Angeles, USA. + + + + eng + + + UL1-DE019580 + the Consortium of Neuropsychiatric Phenomics (CNP) (NIH Roadmap for Medical Research grant + + + + RL1DA024853 + the Consortium of Neuropsychiatric Phenomics (CNP) (NIH Roadmap for Medical Research grant + + + + 1R03AA020186-01 + GF + NIH HHS + United States + + + NIMH T321575 + National Institute of Mental Health + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Res Child Adolesc Psychopathol + 101773609 + 2730-7166 + + IM + + Dynamic structural equation model + Externalizing problems + Parent–child dynamics + +
+ + + + 2023 + 02 + 16 + + + 2023 + 3 + 14 + 12 + 20 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917408 + 10.1007/s10802-023-01045-0 + 10.1007/s10802-023-01045-0 + + + + Achenbach, T. M., & Rescorla, L. A. (2001). Manual for the ASEBA school-age forms & profiles. University of Vermont, Research Center for Children, Youth, and Families. + + + Achenbach, T. M., Dumenci, L., & Rescorla, L. A. (2003). DSM-Oriented and empirically based approaches to constructing scales from the same item pools. Journal of Clinical Child and Adolescent Psychology, 32(3), 332–340. + + 10.1207/S15374424JCCP3203_02 + + + + Asparouhov, T., & Muthén, B. (2019). Latent variable centering of predictors and mediators in multilevel and time-series models. Structural Equation Modeling, 26(1), 119–142. + + 10.1080/10705511.2018.1511375 + + + + Asparouhov, T., Hamaker, E. L., & Muthen, B. (2018). Dynamic structural equation models. 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L., Asparouhov, T., Brose, A., Schmiedek, F., & Muthen, B. (2018). At the frontiers of modeling intensive longitudinal data: Dynamic structural equation models for the affective measurements from the COGITO study. Multivariate Behavioral Research, 53(6), 820–841. + + 29624092 + 10.1080/00273171.2018.1446819 + + + + Kalb, L. M., & Loeber, R. (2003). Child disobedience and noncompliance: A review. Pediatrics, 111(3), 641–652. + + 12612249 + 10.1542/peds.111.3.641 + + + + Kochanska, G., Brock, R. L., Chen, K. H., Aksan, N., & Anderson, S. W. (2015). Paths from mother-child and father-child relationships to externalizing behavior problems in children differing in electrodermal reactivity: A longitudinal study from infancy to age 10. Journal of Abnormal Child Psychology, 43(4), 721–734. + + 25218772 + 4363044 + 10.1007/s10802-014-9938-x + + + + Li, J. J., & Lee, S. S. (2012). Association of positive and negative parenting behavior with childhood ADHD: Interactions with offspring monoamine oxidase A (MAO-A) genotype. Journal of Abnormal Child Psychology, 40(2), 165–175. + + 21826446 + 10.1007/s10802-011-9553-z + + + + Lobo, F. M., & Lunkenheimer, E. (2020). Understanding the parent-child coregulation patterns shaping child self-regulation. Developmental Psychology, 56(6), 1121–1134. + + 32309982 + 7556995 + 10.1037/dev0000926 + + + + Loeber, R., & Burke, J. D. (2011). Developmental pathways in juvenile externalizing and internalizing problems. Journal of Research on Adolescence, 21(1), 34–46. + + 22468115 + 3314340 + 10.1111/j.1532-7795.2010.00713.x + + + + Lougheed, J. P., Hollenstein, T., Lichtwarck-Aschoff, A., & Granic, I. (2015). Maternal regulation of child affect in externalizing and typically-developing children. Journal of Family Psychology, 29(1), 10–19. + + 25401482 + 10.1037/a0038429 + + + + Lunkenheimer, E., & Albrecht., E., & Kemp, C.J. (2013). Dyadic flexibility in early parent-child interactions: Relations with maternal depressive symptoms and child negativity and behavior problems. Infant and Child Development, 22(3), 250–269. + + 24027424 + 10.1002/icd.1783 + + + + Lunkenheimer, E., Tiberio, S. S., Buss, K. A., Lucas-Thompson, R. G., Boker, S. M., & Timpe, Z. C. (2015). Coregulation of respiratory sinus arrhythmia between parents and preschoolers: Differences by children’s externalizing problems. Developmental Psychobiology, 57(8), 994–1003. + + 25976070 + 4644512 + 10.1002/dev.21323 + + + + Lunkenheimer, E., Lichtwarck-Aschoff, A., Hollenstein, T., Kemp, C. J., & Granic, I. (2016). Breaking down the coercive cycle: How parent and child risk factors influence real-time variability in parental responses to child misbehavior. Parenting, 16(4), 237–256. + + 28190978 + 10.1080/15295192.2016.1184925 + + + + Lunkenheimer, E., Ram, N., Skowron, E. A., & Yin, P. (2017). 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The role of the family context in the development of emotional regulation. Social Development, 16(2), 361–388. + + 19756175 + 10.1111/j.1467-9507.2007.00389.x + + + + Muthén, L.K. & Muthén, B.O. (1998–2017). Mplus User’s Guide. Eighth Edition. Los Angeles, CA: Muthén & Muthén. + + + Obradović, J., Sulik, M. J., & Shaffer, A. (2021). Learning to let go: Parental over-engagement predicts poorer self-regulation in kindergartners. Journal of Family Psychology, 35(8), 1160–1170. + + 33705178 + 10.1037/fam0000838 + + + + Owen, D. J., Slep, A. M. S., & Heyman, R. E. (2012). The effect of praise, positive nonverbal response, reprimand, and negative nonverbal response on child compliance: A systematic review. Clinical Child and Family Psychology Review, 15, 364–385. + + 22918669 + 10.1007/s10567-012-0120-0 + + + + Orm, S., Andersen, P. N., Teicher, M. H., Fossum, I. N., Oie, M. G., & Skogli, E. W. (2022). 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+ + + 36917411 + + 2023 + 03 + 14 + +
+ + 2193-8237 + + + 2023 + Mar + 14 + + + Pain and therapy + Pain Ther + + COVID-19-Related Burning Eye Syndrome and Burning Mouth Syndrome: A Systematic Review and Meta-analysis. + 10.1007/s40122-023-00492-3 + + Previous research highlights burning eye syndrome (BES) and burning mouth syndrome (BMS) as chronic complications of COVID-19 infection. The aim of this systematic review and meta-analysis is to establish the prevalence of COVID-19-related BES and COVID-19-related BMS and describe their phenomenology. + A literature search in the PubMed database was performed, and seven papers (five on BES and two on BMS) were eligible to be included in this systematic review and meta-analysis. + The pooled prevalence of COVID-19-related BES was 9.9% (95% CI 3.4-25.4%). The frequency of COVID-19-related BMS is only reported in isolated cases and ranges from 4% in mild-to-moderate cases to 15% in severe, hospitalized cases, with female patients being mostly affected. COVID-19 severity is a potential risk factor for both BES and BMS. Neither syndrome occurs in isolation. COVID-19-related BES usually appears within the first week post-infection, persisting up to 9 weeks later. COVID-19-related BMS occurs during and after initial infection, and may also persist as a chronic disease. + Both BES and BMS are neuropathic COVID-19 infection complications, still under-studied and under-investigated, despite the fact that both are prevalent. Both COVID-19-related BES and COVID-19-related BMS could potentially be initial long COVID syndrome manifestations, and further research should be carried out in this field. + © 2023. The Author(s). + + + + Williams + Laura D + LD + + Medical School, University of Sheffield, Sheffield, UK. + + + + Zis + Panagiotis + P + http://orcid.org/0000-0001-8567-3092 + + Medical School, University of Sheffield, Sheffield, UK. takiszis@gmail.com. + + + Medical School, University of Cyprus, Nicosia, Cyprus. takiszis@gmail.com. + + + Second Department of Neurology, School of Medicine, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece. takiszis@gmail.com. + + + + eng + + Journal Article + Review + + + 2023 + 03 + 14 + +
+ + New Zealand + Pain Ther + 101634491 + + + Burning eyes + Burning mouth + COVID + Long COVID + +
+ + + + 2022 + 12 + 21 + + + 2023 + 02 + 20 + + + 2023 + 3 + 14 + 12 + 21 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917411 + 10.1007/s40122-023-00492-3 + 10.1007/s40122-023-00492-3 + + + + Attal N, Martinez V, Bouhassira D. Potential for increased prevalence of neuropathic pain after the COVID-19 pandemic. Pain Rep. 2021;6(1):e884. + + 10.1097/PR9.0000000000000884 + 33537521 + 7850724 + + + + Barkana Y, Belkin M. Laser eye injuries. Surv Ophthalmol. 2000;44(6):459–78. + + 10.1016/S0039-6257(00)00112-0 + 10906379 + + + + Belmonte C, Acosta MC, Merayo-Lloves J, Gallar J. What causes eye pain? Curr Ophthalmol Rep. 2015;3(2):111–21. + + 10.1007/s40135-015-0073-9 + 26000205 + 4432221 + + + + Bender SD. Burning mouth syndrome. Dent Clin North Am. 2018;62(4):585–96. https://doi.org/10.1016/j.cden.2018.05.006 . (Epub 2018 Jul 27 PMID: 30189984). + + 10.1016/j.cden.2018.05.006 + 30189984 + + + + Berdy GJ, Hedqvist B. 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Oral manifestations in COVID-19 patients: an observational study. J Fam Med Prim Care. 2022;11(3):1000. + + 10.4103/jfmpc.jfmpc_1264_21 + + + + Niedźwiedź A, Kawa M, Pius-Sadowska E, Kuligowska A, Ziontkowska A, Wrzałek D, Parczewski M, Safranow K, Kozłowski K, Machaliński B, Machalińska A. Evaluating ocular symptoms and tear film cytokine profiles in symptomatic COVID-19 patients. J Clin Med. 2022;11(9):2647. + + 10.3390/jcm11092647 + 35566776 + 9105717 + + + + Patel SJ, Lundy DC. Ocular manifestations of autoimmune disease. Am Fam Physician. 2002;66(6):991. + + 12358224 + + + + Richardson WS, Wilson MC, Nishikawa J, Hayward RS. The well-built clinical question: a key to evidence-based decisions. ACP J Club. 1995;123(3):A12–3. + + 10.7326/ACPJC-1995-123-3-A12 + 7582737 + + + + Rokohl AC, Loreck N, Matos PAW, Zwingelberg S, Augustin M, Dewald F, Grajewski RS, Klein F, Lehmann C, Heindl LM. More than loss of taste and smell: burning watering eyes in coronavirus disease 2019. Clin Microbiol Infect. 2020;26(11):1560-e5. + + 10.1016/j.cmi.2020.08.018 + 7442009 + + + + Schreiber AK, Nones CF, Reis RC, Chichorro JG, Cunha JM. Diabetic neuropathic pain: Physiopathology and treatment. World J Diabetes. 2015;6(3):432–44. + + 10.4239/wjd.v6.i3.432 + 25897354 + 4398900 + + + + Seghal G, Bal P, Bal B, Chopra R. Pattern of ocular manifestations and the prevalence of severe acute respiratory syndrome coronavirus-2 in tears of hospitalized coronavirus disease 2019 patients. Taiwan J Ophthalmol. 2021;11(4):380. + + 10.4103/tjo.tjo_40_21 + + + + Shaikh N, Al Mahdi H, Pai A, Pathare A, Abujaber AA, Dsliva A, Al-Jabry M, Subramanian K, Thomas S, Mohmed AS, Anjum S. Ocular manifestations of COVID-19: facts and figures from a tertiary care center. Ann Med. 2022;54(1):310–3. + + 10.1080/07853890.2022.2029554 + 35060821 + 8786237 + + + + Shouman K, Vanichkachorn G, Cheshire WP, Suarez MD, Shelly S, Lamotte GJ, Sandroni P, Benarroch EE, Berini SE, Cutsforth-Gregory JK, Coon EA. Autonomic dysfunction following COVID-19 infection: an early experience. Clin Auton Res. 2021;31(3):385–94. + + 10.1007/s10286-021-00803-8 + 33860871 + 8050227 + + + + Sinjari B, D’Ardes D, Santilli M, Rexhepi I, D’Addazio G, Di Carlo P, Chiacchiaretta P, Caputi S, Cipollone F. SARS-CoV-2 and oral manifestation: an observational, human study. J Clin Med. 2020;9(10):3218. + + 10.3390/jcm9103218 + 33036482 + 7600761 + + + + Skrypnikova T, Skrypnykov P, Shynkevych V. Long term oral symptoms systematization in patients who underwent COVID-19: case series research. J Int Dent Med Res. 2022;15:1133–42. + + + Stern ME, Schaumburg CS, Pflugfelder SC. Dry eye as a mucosal autoimmune disease. Int Rev Immunol. 2013;32(1):19–41. + + 10.3109/08830185.2012.748052 + 23360156 + 3587314 + + + + Sugiyama A, Miwata K, Kitahara Y, Okimoto M, Abe K, Ouoba S, Akita T, Tanimine N, Ohdan H, Kubo T, Nagasawa A. Long COVID occurrence in COVID-19 survivors. Sci Rep. 2022;12(1):1–11. + + 10.1038/s41598-022-10051-z + + + + Vallejo-Garcia JL, Balia L, Raimondi R, Rustioni G, Camesasca FI, Borgia A, Fossati G, Confalonieri F, Legrottaglie EF, Casari E, Sandri MT. Conjunctivitis as a sign of persistent SARS-COV-2 infection? An observational study and report of late symptoms. Eur J Ophthalmol. 2022;32(2):830–5. + + 10.1177/11206721211056594 + 8935141 + + + + Villarroel-Dorrego M, Chacón L, Rosas R, Barrios V, Pernía Y, Vélez H. [Translated article] Oral findings in patients with COVID-19. Actas dermo-sifiliograficas. 2022;113(2):T183–6. + + 10.1016/j.ad.2022.02.002 + 8893314 + + + + Fernández-de-Las-Peñas C, Notarte KI, Peligro PJ, Velasco JV, Ocampo MJ, Henry BM, Arendt-Nielsen L, Torres-Macho J, Plaza-Manzano G. Long-COVID symptoms in individuals infected with different SARS-CoV-2 variants of concern: a systematic review of the literature. Viruses. 2022;14(12):2629. + + 10.3390/v14122629 + 36560633 + 9785120 + + + + +
+ + + 36917410 + + 2023 + 03 + 14 + +
+ + 2190-3948 + + + 2023 + Mar + 14 + + + Drug delivery and translational research + Drug Deliv Transl Res + + CRS Local chapters special issue 2023. + 10.1007/s13346-023-01324-9 + + + Oh + Yu-Kyoung + YK + + College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, 1 Gwanak-ro, Gwanak-gu, 08826, Seoul, Republic of Korea. ohyk@snu.ac.kr. + + + + Schroeder + Avi + A + + Department of Chemical Engineering, Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies Technion-Israel Institute of Technology, 32000, Haifa, Israel. + + + + Sarmento + Bruno + B + + i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen 208, 4200-135, Porto, Portugal. bruno.sarmento@i3s.up.pt. + + + IUCS-CESPU, Rua Central de Gandra 1317, 4585-116, Gandra, Portugal. bruno.sarmento@i3s.up.pt. + + + + eng + + Editorial + + + 2023 + 03 + 14 + +
+ + United States + Drug Deliv Transl Res + 101540061 + 2190-393X + + IM +
+ + + + 2023 + 03 + 06 + + + 2023 + 3 + 14 + 12 + 21 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917410 + 10.1007/s13346-023-01324-9 + 10.1007/s13346-023-01324-9 + + +
+ + + 36917409 + + 2023 + 03 + 14 + +
+ + 2190-3948 + + + 2023 + Mar + 14 + + + Drug delivery and translational research + Drug Deliv Transl Res + + Nanoparticle pre-treatment for enhancing the survival and activation of pulmonary macrophage transplant. + 10.1007/s13346-023-01319-6 + + Despite recent clinical successes of chimeric antigen receptor T cell therapies in treating liquid cancers, many lingering challenges stand in the way of therapeutic translation to broader types of malignancies. Macrophages have been proposed as alternatives to T cells given macrophages' advantages in promoting tumor infiltration, acquiring diverse antigens, and possessing the ability to continuously stimulate adaptive responses. However, the poor survival of macrophages upon transplantation in addition to transient anti-tumor phenotypical states have been major obstacles standing in the way of macrophage-based cell therapies. Given recent discoveries of nanoparticle strategies in improving macrophage survival and promoting phenotype retention, we herein report the ability to extend the survival and phenotype of macrophage transplants in murine lungs via pre-treatment with nanoparticles of varying degradation rates. Macrophages pre-treated with 100 µg/ml dose of poly(ethylene glycol) diacrylate nanoparticle formulations improve pulmonary macrophage transplant survival over untreated cells beyond 7 days, where degradable nanoparticle formulations result in over a 50% increase in retention of transplanted cell counts relative to untreated cells. Furthermore, pre-treated macrophages more efficiently retain an imposed pro-inflammatory-like polarization state following transplantation out to 7 days compared to macrophages pre-treated with a classical pro-inflammatory stimulus, interferon-gamma, where CD86 costimulatory molecule expression is greater than 150% higher in pre-treated macrophage transplants compared to untreated counterparts. These findings provide an avenue for a major improvement in the lifespan and efficacy of macrophage-based cell therapies and have broader implications to other phagocyte-based cellular therapeutics and administration routes. + © 2023. The Author(s). + + + + Jarai + Bader M + BM + http://orcid.org/0000-0001-7099-2461 + + Department of Chemical and Biomolecular Engineering, University of Delaware, 150 Academy St., Newark, DE, 19716, USA. + + + + Bomb + Kartik + K + http://orcid.org/0000-0002-9626-1445 + + Department of Chemical and Biomolecular Engineering, University of Delaware, 150 Academy St., Newark, DE, 19716, USA. + + + + Fromen + Catherine A + CA + http://orcid.org/0000-0002-7528-0997 + + Department of Chemical and Biomolecular Engineering, University of Delaware, 150 Academy St., Newark, DE, 19716, USA. cfromen@udel.edu. + + + + eng + + + R35GM142866 + GM + NIGMS NIH HHS + United States + + + P20 GM139760 + GM + NIGMS NIH HHS + United States + + + 20A00066 + Pharmaceutical Research and Manufacturers of America Foundation + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Drug Deliv Transl Res + 101540061 + 2190-393X + + IM + + Cell therapy + Macrophages + Nanoparticles + Polarization + Pulmonary transplant + Survival + +
+ + + + 2023 + 02 + 21 + + + 2023 + 3 + 14 + 12 + 20 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917409 + 10.1007/s13346-023-01319-6 + 10.1007/s13346-023-01319-6 + + + + Dantuma E, Merchant S, Sugaya K. Stem cells for the treatment of neurodegenerative diseases. Stem Cell Res Ther. 2010;1:37. + + 10.1186/scrt37 + 21144012 + 3025439 + + + + Dazzi F, van Laar JM, Cope A, Tyndall A. Cell therapy for autoimmune diseases. Arthritis Res Ther. 2007;9:206–206. + + 10.1186/ar2128 + 17367542 + 1906794 + + + + June CH, Sadelain M. Chimeric antigen receptor therapy. N Engl J Med. 2018;379:64–73. + + 10.1056/NEJMra1706169 + 29972754 + 7433347 + + + + Miliotou NA, Papadopoulou CL. CAR T-cell therapy: a new era in cancer immunotherapy. Curr Pharm Biotechnol. 2018;19:5–18. + + 10.2174/1389201019666180418095526 + 29667553 + + + + Shah NN, Fry TJ. Mechanisms of resistance to CAR T cell therapy. Nat Rev Clin Oncol. 2019;16:372–85. + + 30837712 + 8214555 + + + + Pan K, Farrukh H, Chittepu VCSR, Xu H, Pan C-X, Zhu Z. CAR race to cancer immunotherapy: from CAR T, CAR NK to CAR macrophage therapy. J Exp Clin Cancer Res. 2022;41:119. + + 10.1186/s13046-022-02327-z + 35361234 + 8969382 + + + + Klichinsky M, Ruella M, Shestova O, Lu XM, Best A, Zeeman M, Schmierer M, Gabrusiewicz K, Anderson NR, Petty NE, Cummins KD, Shen F, Shan X, Veliz K, Blouch K, Yashiro-Ohtani Y, Kenderian SS, Kim MY, O’Connor RS, Wallace SR, Kozlowski MS, Marchione DM, Shestov M, Garcia BA, June CH, Gill S. Human chimeric antigen receptor macrophages for cancer immunotherapy. Nat Biotechnol. 2020;38:947–53. + + 10.1038/s41587-020-0462-y + 32361713 + 7883632 + + + + Morrissey MA, Williamson AP, Steinbach AM, Roberts EW, Kern N, Headley MB, Vale RD. Chimeric antigen receptors that trigger phagocytosis. elife. 2018;7. + + + Wang S, Yang Y, Ma P, Zha Y, Zhang J, Lei A, Li N. 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Mediators Inflamm. 2015;2015:816460. + + 10.1155/2015/816460 + 26089604 + 4452191 + + + + Jarai BM, Fromen CA. Nanoparticle internalization promotes the survival of primary macrophages. Adv NanoBiomed Res. 2022; 2100127. + + + Jarai BM, Stillman Z, Fromen CA. Hydrogel nanoparticle degradation influences the activation and survival of primary macrophages. J Mater Chem B. 2021;9:7246–57. + + 10.1039/D1TB00982F + 34226910 + 8446340 + + + + Suzuki T, Arumugam P, Sakagami T, Lachmann N, Chalk C, Sallese A, Abe S, Trapnell C, Carey B, Moritz T, Malik P, Lutzko C, Wood RE, Trapnell BC. Pulmonary macrophage transplantation therapy. Nature. 2014;514:450–4. + + 10.1038/nature13807 + 25274301 + 4236859 + + + + Chisolm DA, Cheng W, Colburn SA, Silva-Sanchez A, Meza-Perez S, Randall TD, Weinmann AS. Defining genetic variation in widely used congenic and backcrossed mouse models reveals varied regulation of genes important for immune responses. 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J Innate Immun. 2010;2:204–15. + + 10.1159/000296507 + 20375558 + 2956013 + + + + Andreesen R, Scheibenbogen C, Brugger W, Krause S, Meerpohl HG, Leser HG, Engler H, Löhr GW. Adoptive transfer of tumor cytotoxic macrophages generated in vitro from circulating blood monocytes: a new approach to cancer immunotherapy. Cancer Res. 1990;50:7450–6. + + 1701343 + + + + Bercovici N, Guérin MV, Trautmann A, Donnadieu E. The remarkable plasticity of macrophages: a chance to fight cancer. Front Immunol. 2019;10:1563. + + 10.3389/fimmu.2019.01563 + 31354719 + 6640155 + + + + Lee S, Kivimäe S, Dolor A, Szoka FC. Macrophage-based cell therapies: the long and winding road. J Control Release. 2016;240:527–40. + + 10.1016/j.jconrel.2016.07.018 + 27422609 + 5064880 + + + + Shields CW, Evans MA, Wang LL-W, Baugh N, Iyer S, Wu D, Zhao Z, Pusuluri A, Ukidve A, Pan DC, Mitragotri S. Cellular backpacks for macrophage immunotherapy. 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+ + + 36917412 + + 2023 + 03 + 14 + +
+ + 1573-2584 + + + 2023 + Mar + 14 + + + International urology and nephrology + Int Urol Nephrol + + Is systematic prostate biopsy an overkill in metastatic prostate carcinoma ? A prospective validation. + 10.1007/s11255-023-03531-2 + + To assess the efficacy of 2-core prostate biopsy in advanced prostate cancer patients. This included a retrospective analysis of 12-core prostate biopsies and a prospective validation that a reduced number of cores are sufficient for histopathological diagnosis. + The first phase analyzed retrospective data from 12-core prostate biopsies between January 2013 and 2018. In the second phase, from January 2018 to January 2022, in a prospective setting, patients with PSA > 75 ng/dl underwent bone scans first. Those with positive bone scans underwent a 2-core biopsy. Cancer detection rate and complications were analyzed to validate the findings of the first phase. + In the retrospective analysis, the number of positive cores in metastatic disease was 12 in 93 (73.8%), 11 in 14 (11.1%), and 10 in 7 (5.6%) patients. Using probability analysis, 94% of patients with metastasis could be detected with a single core and 97.8% with a 2-core biopsy. In the prospective analysis, 52 patients with PSA > 75 were enrolled. 3/52 (5.7%) patients had a negative bone scan. 49 were assigned for 2-core biopsy, out of which 48 (97.9%) had a positive result. One patient underwent a repeat 12-core biopsy. The prospective cohort's complications (p = 0.003) and pain score (p = 0.03) were lower compared to patients who underwent standard 12-core biopsies during phase one of the study period. + A 2-core biopsy is adequate in almost all patients with metastatic prostate cancer with PSA > 75, and this avoids excess complications and morbidity associated with a systematic 12-core prostate biopsy. + © 2023. The Author(s), under exclusive licence to Springer Nature B.V. + + + + Sureka + Sanjoy Kumar + SK + + Department of Urology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India. drsksureka@gmail.com. + + + + Misra + Ankit + A + + Department of Urology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India. + + + + Raj + Himanshu + H + + Department of Urology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India. + + + + Shukla + Anupam + A + + Department of Urology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India. + + + + Singh + Uday Pratap + UP + + Department of Urology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Netherlands + Int Urol Nephrol + 0262521 + 0301-1623 + + IM + + Histopathology + Metastatic prostate cancer + Prostate specific antigen + Systematic core biopsy + +
+ + + + 2023 + 01 + 02 + + + 2023 + 02 + 17 + + + 2023 + 3 + 14 + 12 + 21 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917412 + 10.1007/s11255-023-03531-2 + 10.1007/s11255-023-03531-2 + + + + Hebert JR, Ghumare SS, Gupta PC (2019) Stage at diagnosis and relative differences in breast and prostate cancer incidence in India: comparison with the United States. Asian Pac J Cancer Prev 7(4):547–555 + + + Hodge K, Mcneal J, Stamey T (1989) Ultrasound guided transrectal core biopsies of the palpably abnormal prostate. J Urol 142(1):66–70 + + 10.1016/S0022-5347(17)38663-9 + 2659826 + + + + Tanaka N, Shimada K, Nakagawa Y et al (2015) The optimal number of initial prostate biopsy cores in daily practice: a prospective study using the Nara urological research and treatment group nomogram. BMC Res Notes 8:689. https://doi.org/10.1186/s13104-015-1668-9 + + 10.1186/s13104-015-1668-9 + 26581414 + 4652389 + + + + Mottet N, Cornford P, Van Den Bergh R, Briers V, De Santis M, Grummet J. et al. (2021) EAU-EANM-ESTRO-ESUR-ISUP-SIOG Guidelines On Prostate Cancer. EAU Guidelines Office. Arnhem, The Netherlands: 2021. pp. 25–42. Available From: https://uroweb.org/wp-content/uploads/eau-eanm-estro-esur-isup-siog-guidelines-on-prostate-cancer-2021v4.pdf . [Accessed On 2021 Aug 7] + + + Hodge K, Mcneal J, Terris M, Stamey T (1989) Random systematic versus directed ultrasound guided transrectal core biopsies of the prostate. J Urol 142(1):71–74 + + 10.1016/S0022-5347(17)38664-0 + 2659827 + + + + Naughton C, Miller D, Yan Y (2001) Impact of transrectal ultrasound guided prostate biopsy on quality of life: a prospective randomized trial comparing 6 versus 12 cores. J Urol 165(1):100–103 + + 10.1097/00005392-200101000-00025 + 11125374 + + + + Fuganti PE, Tobias-Machado M, Pinto MA, Simardi LH, Wroclawski ER. Twelve Core Prostate Biopsy Versus Six Systematic Sextant Biopsies. Accessed July 7, 2019. http://www.brazjurol.com.br/may_june_2002/Fuganti_ing_207_213.pdf + + + Jiang J, Colli J, El-Galley R (2010) A simple method for estimating the optimum number of prostate biopsy cores needed to maintain high cancer detection rates while minimizing unnecessary biopsy sampling. J Endourol 24(1):143–147. https://doi.org/10.1089/end.2009.0285 + + 10.1089/end.2009.0285 + 20001330 + + + + Yücel C, Budak S, Kısa E, Celik O, Kozacıoglu Z (2018) The sufficiency of 6 core sextant prostate biopsy in patients with prostate specific antigen (PSA) values over 20 ng/mL. Arch Ital di Urol e Androl 90(2):104. https://doi.org/10.4081/aiua.2018.2.104 + + 10.4081/aiua.2018.2.104 + + + + Heyns CF, Naudé AM, Ahmed G, Stopforth HB, Stellmacher GA, Visser AJ (2001) Serum prostate-specific antigen as surrogate for the histological diagnosis of prostate cancer. S Afr Med J 91(8):685–689 + + 11584785 + + + + Gerstenbluth RE, Seftel AD, Hampel N, Oefelein MG, Resnick MI (2002) The accuracy of the increased prostate specific antigen level (greater than or equal to 20 ng./ml.) in predicting prostate cancer: is biopsy always required? J Urol 168(5):1990–1993. https://doi.org/10.1097/01.ju.0000033330.06269.6d + + 10.1097/01.ju.0000033330.06269.6d + 12394692 + + + + Raaijmakers R, Kirkels WJ, Roobol MJ, Wildhagen MF, Schrder FH (2002) Complication rates and risk factors of 5802 transrectal ultrasound-guided sextant biopsies of the prostate within a population-based screening program. Urology 60(5):826–830 + + 10.1016/S0090-4295(02)01958-1 + 12429309 + + + + Naughton CK, Ornstein DK, Smith DS, Catalona WJ (2000) Pain and morbidity of transrectal ultrasound guided prostate biopsy: a prospective randomized trial of 6 versus 12 cores. J Urol 163(1):168–171 + + 10.1016/S0022-5347(05)67996-7 + 10604338 + + + + Han KS, Lee KH (2008) Korean urologic oncology society prostate cancer study group factors influencing pain during transrectal ultrasonography-guided prostate biopsy. Prostate Cancer Prostatic Dis 11(2):139–142. https://doi.org/10.1038/sj.pcan.4501004 + + 10.1038/sj.pcan.4501004 + 17710107 + + + + Grummet J, Weerakoon M, Huang S, Lawrentschuk N, Frydenberg M, Moon D et al (2014) Sepsis and ‘superbugs’: should we favour the transperineal over the transrectal approach for prostate biopsy? BJU Int 114:384–388 + + 24612341 + + + + Laddha A, Thomas A, Nair DC, Ravindran GC, Pooleri GK (2020) Outcome of TRUS biopsy with limited cores in patients with PSA more than 50 ng/dL: can we reduce the number of cores without affecting outcomes? Indian J Surg Oncol 11(3):509–512. https://doi.org/10.1007/s13193-020-01165-9 + + 10.1007/s13193-020-01165-9 + 33013136 + 7501352 + + + + +
+ + + 36917413 + + 2023 + 03 + 14 + +
+ + 1573-2584 + + + 2023 + Mar + 14 + + + International urology and nephrology + Int Urol Nephrol + + Trends in mortality and comorbidities in hemodialysis patients between 2012 and 2017 in an East-European Country: a retrospective study. + 10.1007/s11255-023-03549-6 + + The aim of this study was to evidence trends and changes in mortality, comorbid conditions, prognosis, and causes of death after 5 years of continuous evolution of hemodialysis (HD) patients in Romania. + We included two cohorts of stable HD patients (901 from 2012 and 1396 from 2017). Both cohorts were followed up for 1 year. The 5-year survivors of the 2012 cohort were identified in 2017 and their data changes were assessed. + The 2017 patients were older, with longer time on dialysis, higher serum creatinine and urea levels, and required higher ultrafiltration volume per dialysis. They also had lower hemoglobin, lower C-reactive protein, higher albumin, higher calcium bicarbonate, and higher parathyroidectomy prevalence. The 2017 cohort presented with lower average dialysis flow, less administration of iron sucrose, had more catheters, lower hepatitis C prevalence, higher diabetes mellitus prevalence, higher heart valve calcifications, higher heart rate disorders, higher prevalence of left ventricular hypertrophy, and lower ejection fraction. Cardiovascular disease was the main cause of death in both years (50% in 2012 and 45.6% in 2017), followed by sepsis and cancer. The mortality was higher in 2017 compared to 2012 (14.1 vs 6.6%). The 5-year mortality was 37.2% with an average of 7.44%/year. The risk of death increased with age, higher C-reactive protein, higher phosphate, lower hemoglobin, and lower albumin. + Cardiovascular disease remains the main causes of death in HD-treated patients but with decreasing trend. Developing regional therapeutic strategies for quality care with early intervention will most likely improve mortality. + © 2023. The Author(s). + + + + Chisavu + Lazar + L + http://orcid.org/0000-0003-3664-1945 + + University of Medicine and Pharmacy "Victor Babes" Timisoara, Timisoara, Romania. + + + Avitum BBraun Dialysis Centre, Timisoara, Romania. + + + + Mihaescu + Adelina + A + http://orcid.org/0000-0002-3220-6623 + + University of Medicine and Pharmacy "Victor Babes" Timisoara, Timisoara, Romania. mihaescu.adelina@umft.ro. + + + Emergency County Hospital "Pius Brinzeu" Timisoara, Timisoara, Romania. mihaescu.adelina@umft.ro. + + + + Bob + Flaviu + F + http://orcid.org/0000-0001-5082-3126 + + University of Medicine and Pharmacy "Victor Babes" Timisoara, Timisoara, Romania. + + + Emergency County Hospital "Pius Brinzeu" Timisoara, Timisoara, Romania. + + + + Motofelea + Alexandru + A + https://orcid.org/0000-0003-4297-077X + + University of Medicine and Pharmacy "Victor Babes" Timisoara, Timisoara, Romania. + + + Emergency City Hospital of Timisoara, Timisoara, Romania. + + + + Schiller + Oana + O + + Avitum BBraun Dialysis Centre, Timisoara, Romania. + + + + Marc + Luciana + L + + University of Medicine and Pharmacy "Victor Babes" Timisoara, Timisoara, Romania. + + + Avitum BBraun Dialysis Centre, Timisoara, Romania. + + + + Dragota-Pascota + Razvan + R + + University of Medicine and Pharmacy "Victor Babes" Timisoara, Timisoara, Romania. + + + Emergency County Hospital "Pius Brinzeu" Timisoara, Timisoara, Romania. + + + + Chisavu + Flavia + F + http://orcid.org/0000-0001-9456-4517 + + University of Medicine and Pharmacy "Victor Babes" Timisoara, Timisoara, Romania. + + + Emergency Hospital for Children "Louis Turcanu" Timisoara, Timisoara, Romania. + + + + Schiller + Adalbert + A + http://orcid.org/0000-0001-6843-7653 + + University of Medicine and Pharmacy "Victor Babes" Timisoara, Timisoara, Romania. + + + Emergency County Hospital "Pius Brinzeu" Timisoara, Timisoara, Romania. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Netherlands + Int Urol Nephrol + 0262521 + 0301-1623 + + IM + + Cardiovascular death + Cardiovascular disease + Comorbidities + Hemodialysis + Mortality + Survival + +
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+ + + 36917414 + + 2023 + 03 + 14 + +
+ + 1573-2584 + + + 2023 + Mar + 14 + + + International urology and nephrology + Int Urol Nephrol + + J-shaped association of free triiodothyronine to free thyroxine ratio with 5-year mortality among patients with chronic kidney disease: a prospective cohort study. + 10.1007/s11255-023-03548-7 + + To investigate the association of free triiodothyronine to free thyroxine (FT3/FT4) ratio with 5-year mortality in patients with chronic kidney disease (CKD) using data from the National Health and Nutrition Examination Survey (NHANES) through 2001-2002 and 2007-2012. + Two thousand four hundred twenty-four patients with CKD stage 1-5 were included. Patients' baseline characteristics were collected. Cox proportional hazards models were used to investigate the association of FT3/FT4 ratio with 5-year all-cause and cardiovascular mortality. Subgroup analysis was performed. + Within 5 years of follow-up duration, 425 (17.53%) deaths were recorded, and 154 patients died from cardiovascular disease. A J-shaped association between FT3/FT4 ratio and 5-year mortality was observed. After fully adjustment, the elevated FT3/FT4 ratio was significantly associated with a decreased 5-year all-cause mortality risk (HR: 0.79, 95% CI 0.63-0.99) among patients with CKD stage 1-5 when FT3/FT4 ratio < 4.71, and is significantly associated with an increased 5-year all-cause mortality risk in CKD patients with advanced CKD stages or low UACR when FT3/FT4 ratio ≥ 4.71 (HR: 2.74, 95% CI 1.20-6.29; HR: 3.09, 95% CI 1.12-8.57, respectively). The elevated FT3/FT4 ratio also showed a J-shaped association with the 5-year cardiovascular mortality which disappears after fully adjustment. + The FT3/FT4 ratio is closely associated with 5-year mortality risk among patients with CKD, indicating a potential role of FT3/FT4 ratio as a biomarker for mortality prediction in CKD patients. + © 2023. The Author(s), under exclusive licence to Springer Nature B.V. + + + + Li + Siyao + S + + Department of Nephrology, The Second Xiangya Hospital of Central South University, Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, 410011, China. + + + + Zeng + Mengru + M + http://orcid.org/0000-0002-9735-8417 + + Department of Nephrology, The Second Xiangya Hospital of Central South University, Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, 410011, China. zengmengru@csu.edu.cn. + + + + eng + + + 82200813 + National Natural Science Foundation of China + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + Netherlands + Int Urol Nephrol + 0262521 + 0301-1623 + + IM + + CKD + FT3 + FT4 + Mortality + +
+ + + + 2022 + 12 + 06 + + + 2023 + 03 + 04 + + + 2023 + 3 + 14 + 12 + 21 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917414 + 10.1007/s11255-023-03548-7 + 10.1007/s11255-023-03548-7 + + + + Kalantar-Zadeh K et al (2021) Chronic kidney disease. Lancet 398(10302):786–802. https://doi.org/10.1016/S0140-6736(21)00519-5 + + 10.1016/S0140-6736(21)00519-5 + 34175022 + + + + Levey AS et al (2005) Definition and classification of chronic kidney disease: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int 67(6):2089–2100. https://doi.org/10.1111/j.1523-1755.2005.00365.x + + 10.1111/j.1523-1755.2005.00365.x + 15882252 + + + + Jankowski J et al (2021) Cardiovascular disease in chronic kidney disease: pathophysiological insights and therapeutic options. 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Med Sci Monit 22:1171–1179. https://doi.org/10.12659/msm.895953 + + 10.12659/msm.895953 + 27056188 + 4827515 + + + + Xu LC et al (2021) The correlation between low serum T3 levels and all-cause and cardiovascular mortality in peritoneal dialysis patients. Ther Clin Risk Manag 17:851–861. https://doi.org/10.2147/TCRM.S324672 + + 10.2147/TCRM.S324672 + 34434048 + 8382308 + + + + Drechsler C et al (2014) Thyroid function, cardiovascular events, and mortality in diabetic hemodialysis patients. Am J Kidney Dis 63(6):988–996. https://doi.org/10.1053/j.ajkd.2013.10.009 + + 10.1053/j.ajkd.2013.10.009 + 24315768 + + + + Schultheiss UT et al (2021) Thyroid function, renal events and mortality in chronic kidney disease patients: the German Chronic Kidney Disease study. Clin Kidney J 14(3):959–968. https://doi.org/10.1093/ckj/sfaa052 + + 10.1093/ckj/sfaa052 + 34349984 + + + + Shimizu Y et al (2022) Associations among Ratio of Free Triiodothyronine to Free Thyroxine, Chronic Kidney Disease, and Subclinical Hypothyroidism. J Clin Med. https://doi.org/10.3390/jcm11051269 + + 10.3390/jcm11051269 + 36615131 + 9787409 + + + + Inaba M et al (2021) Association of Reduced Free T3 to Free T4 Ratio with Lower Serum Creatinine in Japanese Hemodialysis Patients. Nutrients. https://doi.org/10.3390/nu13124537 + + 10.3390/nu13124537 + 34960089 + 8703624 + + + + Zhang L et al (2022) The serum free triiodothyronine to free thyroxine ratio as a potential prognostic biomarker of chronic kidney disease in patients with glomerular crescents: a retrospective study. Front Endocrinol (Lausanne) 13:977355. https://doi.org/10.3389/fendo.2022.977355 + + 10.3389/fendo.2022.977355 + 36246924 + + + + Chen TC et al (2018) National health and nutrition examination survey: estimation procedures, 2011–2014. Vital Health Stat 2 177:1–26 + + + Miller WG et al (2022) National Kidney Foundation Laboratory Engagement Working Group Recommendations for Implementing the CKD-EPI 2021 Race-Free Equations for Estimated Glomerular Filtration Rate: Practical Guidance for Clinical Laboratories. Clin Chem 68(4):511–520. https://doi.org/10.1093/clinchem/hvab278 + + 10.1093/clinchem/hvab278 + 34918062 + + + + Murphy D et al (2016) Trends in prevalence of chronic kidney disease in the United States. Ann Intern Med 165(7):473–481. https://doi.org/10.7326/M16-0273 + + 10.7326/M16-0273 + 27479614 + 5552458 + + + + Zhang NH et al (2020) Leisure-time physical activity and mortality in CKD: a 1999–2012 NHANES analysis. Am J Nephrol 51(11):919–929. https://doi.org/10.1159/000511685 + + 10.1159/000511685 + 33207339 + + + + Kim D et al (2021) Metabolic dysfunction-associated fatty liver disease is associated with increased all-cause mortality in the United States. J Hepatol 75(6):1284–1291. https://doi.org/10.1016/j.jhep.2021.07.035 + + 10.1016/j.jhep.2021.07.035 + 34380057 + + + + Ataoglu HE et al (2018) Prognostic significance of high free T4 and low free T3 levels in non-thyroidal illness syndrome. Eur J Intern Med 57:91–95. https://doi.org/10.1016/j.ejim.2018.07.018 + + 10.1016/j.ejim.2018.07.018 + 30029851 + + + + Yang JW et al (2012) Serum T3 level can predict cardiovascular events and all-cause mortality rates in CKD patients with proteinuria. Ren Fail 34(3):364–372. https://doi.org/10.3109/0886022X.2011.647342 + + 10.3109/0886022X.2011.647342 + 22260378 + + + + Rhee CM (2015) Low-T3 syndrome in peritoneal dialysis: metabolic adaptation, marker of illness, or mortality mediator? Clin J Am Soc Nephrol 10(6):917–919. https://doi.org/10.2215/CJN.04310415 + + 10.2215/CJN.04310415 + 25979973 + 4455204 + + + + Li J et al (2020) Association of Serum Thyroid Hormones with the Risk and Severity of Chronic Kidney Disease Among 3563 Chinese Adults. Med Sci Monit 26:e922910. https://doi.org/10.1265/MSM.922910 + + 10.1265/MSM.922910 + 32569261 + 7331475 + + + + Lang X et al (2022) FT3/FT4 ratio is correlated with all-cause mortality, cardiovascular mortality, and cardiovascular disease risk: NHANES 2007–2012. Front Endocrinol (Lausanne) 13:964822. https://doi.org/10.3389/fendo.2022.964822 + + 10.3389/fendo.2022.964822 + 36060933 + + + + Kozdag G et al (2005) Relation between free triiodothyronine/free thyroxine ratio, echocardiographic parameters and mortality in dilated cardiomyopathy. Eur J Heart Fail 7(1):113–118. https://doi.org/10.1016/j.ejheart.2004.04.016 + + 10.1016/j.ejheart.2004.04.016 + 15642542 + + + + Neves JS et al (2019) Lower free triiodothyronine levels within the reference range are associated with higher cardiovascular mortality: an analysis of the NHANES. Int J Cardiol 285:115–120. https://doi.org/10.1016/j.ijcard.2019.03.009 + + 10.1016/j.ijcard.2019.03.009 + 30879936 + + + + Yuan D et al (2021) Usefulness of FT3 to FT4 ratio to predict mortality in euthyroid patients with prior cardiovascular events undergoing PCI: five-year findings from a large single-center cohort study. Front Endocrinol (Lausanne) 12:700349. https://doi.org/10.3389/fendo.2021.700349 + + 10.3389/fendo.2021.700349 + 34290672 + + + + Wang C et al (2022) Value of FT3/FT4 ratio in prognosis of patients with heart failure: a propensity-matched study. 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+ + + 36917415 + + 2023 + 03 + 14 + +
+ + 1591-9528 + + + 2023 + Mar + 14 + + + Clinical and experimental medicine + Clin Exp Med + + Correction to: Is there a role for microbiome‑based approach in common variable immunodeficiency? + 10.1007/s10238-023-01032-1 + + + Poto + Remo + R + http://orcid.org/0000-0002-4723-0167 + + Department of Translational Medical Sciences, University of Naples Federico II, 80131, Naples, Italy. + + + Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, 80131, Naples, Italy. + + + World Allergy Organization (WAO), Center of Excellence, 80131, Naples, Italy. + + + Department of Oncology and Molecular Medicine, Istituto Superiore Di Sanità (ISS), Rome, Italy. + + + + Ianiro + Gianluca + G + http://orcid.org/0000-0002-8318-0515 + + Digestive Disease Center, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy. + + + Department of Translational Medicine and Surgery, Catholic University of Rome, Rome, Italy. + + + + de Paulis + Amato + A + http://orcid.org/0000-0003-0347-2540 + + Department of Translational Medical Sciences, University of Naples Federico II, 80131, Naples, Italy. + + + Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, 80131, Naples, Italy. + + + World Allergy Organization (WAO), Center of Excellence, 80131, Naples, Italy. + + + + Spadaro + Giuseppe + G + http://orcid.org/0000-0001-7889-425X + + Department of Translational Medical Sciences, University of Naples Federico II, 80131, Naples, Italy. + + + Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, 80131, Naples, Italy. + + + World Allergy Organization (WAO), Center of Excellence, 80131, Naples, Italy. + + + + Marone + Gianni + G + http://orcid.org/0000-0002-9849-4701 + + Department of Translational Medical Sciences, University of Naples Federico II, 80131, Naples, Italy. + + + Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, 80131, Naples, Italy. + + + World Allergy Organization (WAO), Center of Excellence, 80131, Naples, Italy. + + + Institute of Experimental Endocrinology and Oncology (IEOS), National Research Council, 80131, Naples, Italy. + + + + Gasbarrini + Antonio + A + http://orcid.org/0000-0003-4863-6924 + + Digestive Disease Center, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy. + + + Department of Translational Medicine and Surgery, Catholic University of Rome, Rome, Italy. + + + + Varricchi + Gilda + G + http://orcid.org/0000-0002-9285-4657 + + Department of Translational Medical Sciences, University of Naples Federico II, 80131, Naples, Italy. gildanet@gmail.com. + + + Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, 80131, Naples, Italy. gildanet@gmail.com. + + + World Allergy Organization (WAO), Center of Excellence, 80131, Naples, Italy. gildanet@gmail.com. + + + Institute of Experimental Endocrinology and Oncology (IEOS), National Research Council, 80131, Naples, Italy. gildanet@gmail.com. + + + + eng + + Published Erratum + + + 2023 + 03 + 14 + +
+ + Italy + Clin Exp Med + 100973405 + 1591-8890 + + IM + + + Clin Exp Med. 2023 Feb 3;: + 36737487 + + +
+ + + + 2023 + 3 + 14 + 12 + 21 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917415 + 10.1007/s10238-023-01032-1 + 10.1007/s10238-023-01032-1 + + +
+ + + 36917416 + + 2023 + 03 + 14 + +
+ + 1559-0100 + + + 2023 + Mar + 14 + + + Endocrine + Endocrine + + The addition of corticotropin-releasing hormone to 2-day low dose dexamethasone suppression test provides additional case detection. + 10.1007/s12020-023-03327-5 + + PURPOSE: The diagnostic value of adding a Corticotropin-Releasing Hormone (CRH) Stimulation Test to the 2-day Low Dose Dexamethasone Suppression Test (Dex-CRH Test) has been debated in the literature. + We identified 65 patients with Cushing disease (CD) and 42 patients in whom a diagnosis of Cushing disease could not be confirmed (NCD) after a minimum follow-up of 14 months who underwent the Dex-CRH test. + The female sex ratio, median (range) age, and BMI were similar between the two groups. The follow-up for patients with CD and NCD was 74 (4-233) and 52 (14-146) months, respectively. Among 65 patients with CD, 5 (7.7%) had a cortisol level ≤1.4 µg/dl after LDDST but were appropriately classified as CD with a cortisol level >1.4 µg/dL at 15-min post CRH stimulation. In contrast, 3/42 patients (7.1%) in NCD had an abnormal Dex-CRH test. In only one of three patients, the LDDST was marginally normal (cortisol was 1.4 µg/dL and increased to 3.1 µg/dL 15-min post CRH). A cortisol cutoff value of >1.4 µg/dL during the Dex-CRH test provided a sensitivity of 100%, specificity of 93%, and diagnostic accuracy of 97% to diagnose CD. When patients without a Dex level were excluded (n = 74), the sensitivity did not change, but the specificity and accuracy of the Dex-CRH test increased to 97 and 99%, respectively. + The Dex-CRH Test provided additional case detection in 5/65 (7.7%) patients with CD. It resulted in one false-positive case compared to LDDST. Measurement of dexamethasone improved diagnostic accuracy of the test. + © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. + + + + Wehbeh + Leen + L + + Department of Medicine, Division of Diabetes, Endocrinology & Metabolism, Johns Hopkins University, Baltimore, MD, USA. + + + + Alwahab + Ula Abed + UA + + Department of Endocrinology, Endocrinology & Metabolism Institute, Cleveland Clinic, Cleveland, OH, USA. + + + + Mikhael + Alexandra + A + + Department of Endocrinology, Endocrinology & Metabolism Institute, Cleveland Clinic, Cleveland, OH, USA. + + + + Dobri + Georgiana + G + + Departments of Neurosurgery and Endocrinology, Weill Cornell Medicine, New York, NY, USA. + + + + Yogi-Morren + Divya + D + + Department of Endocrinology, Endocrinology & Metabolism Institute, Cleveland Clinic, Cleveland, OH, USA. + + + + Kennedy + Laurence + L + + Department of Endocrinology, Endocrinology & Metabolism Institute, Cleveland Clinic, Cleveland, OH, USA. + + + + Hamrahian + Amir H + AH + http://orcid.org/0000-0001-8832-9385 + + Department of Medicine, Division of Diabetes, Endocrinology & Metabolism, Johns Hopkins University, Baltimore, MD, USA. ahamrah1@jmhi.edu. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Endocrine + 9434444 + 1355-008X + + IM + + CRH test + Cushing disease + Cushing syndrome + Dex CRH test + Dexamethasone Suppression test + +
+ + + + 2022 + 12 + 01 + + + 2023 + 02 + 10 + + + 2023 + 3 + 14 + 12 + 21 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917416 + 10.1007/s12020-023-03327-5 + 10.1007/s12020-023-03327-5 + + + + L.K. Nieman, B.M.K. Biller, J.W. Findling, J. Newell-Price, M.O. Savage, P.M. Stewart, H. Edwards, The diagnosis of Cushing’s syndrome: An endocrine society clinical practice guideline. J. Clin. Endocrinol. Metab. 93(5), 1526–1540 (2008). https://doi.org/10.1210/jc.2008-0125 + + 10.1210/jc.2008-0125 + 18334580 + 2386281 + + + + J.W. Findling, H. Raff, Differentiation of pathologic/neoplastic hypercortisolism (Cushing’s syndrome) from physiologic/non-neoplastic hypercortisolism (formerly known as pseudo-Cushing’s syndrome). Eur. J. Endocrinol. 176(5), R205–R216 (2017). https://doi.org/10.1530/EJE-16-0946 + + 10.1530/EJE-16-0946 + 28179447 + + + + G.W. Liddle, Tests of pituitary-adrenal suppressibility in the diagnosis of cushing’s syndrome. J. Clin. Endocrinol. Metab. 20(12), 1539–1560 (1960). https://doi.org/10.1201/9781840765854 + + 10.1201/9781840765854 + 13761950 + + + + L. Kennedy, A.B. Atkinson, H. Johnston, B. Sheridan, D.R. Hadden, Serum cortisol concentrations during low dose dexamethasone suppression test to screen for Cushing’s syndrome. Brit. Med. J. 289, 1188–1191 (1984). https://doi.org/10.1136/bmj.289.6453.1188 + + 10.1136/bmj.289.6453.1188 + + + + T.B. Kaye, L. Crapo, The Cushing syndrome: an update on diagnostic tests. Ann. Intern. Med. 112(6), 434–444 (1990). https://doi.org/10.7326/0003-4819-76-3-112-6-434 + + 10.7326/0003-4819-76-3-112-6-434 + 2178536 + + + + J. Newell-Price, P. Trainer, M. Besser, A. Grossman, The diagnosis and differential diagnosis of Cushing’s syndrome and pseudo-Cushing’s states. Endocr. Rev. 19(5), 647–672 (1998). https://academic.oup.com/edrv/article/19/5/647/2530832 + + 9793762 + + + + P. Wood, J. Barth, D. Freedman, L. Perry, B. Sheridan, Evidence for the low dose dexamethasone suppression test to screen for Cushing’s syndrome - recommendations for a protocol for biochemistry laboratories. Ann. Clin. Biochem 34, 222–229 (1997) + + 10.1177/000456329703400302 + 9158818 + + + + J.A. Yanovski, G.B. Cutler, G.P. Chrousos, L.K. Nieman, Corticotropin-releasing hormone stimulation following low-dose dexamethasone administration. JAMA 269(17), 2232–2238 (1993). https://doi.org/10.1001/jama.1993.03500170062035 + + 10.1001/jama.1993.03500170062035 + 8386285 + + + + N.M. Martin, W.S. Dhillo, A. Banerjee, A. Abdulali, C.N. Jayasena, M. Donaldson, K. Meeran, Comparison of the dexamethasone-suppressed corticotropin-releasing hormone test and low-dose dexamethasone suppression test in the diagnosis of Cushing’s syndrome. J. Clin. Endocrinol. Metab. 91(7), 2582–2586 (2006). https://doi.org/10.1210/jc.2005-2143 + + 10.1210/jc.2005-2143 + 16670165 + + + + D. Erickson, N. Natt, T. Nippoldt, W.F. Young, P.C. Carpenter, T. 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+ + + 36917422 + + 2023 + 03 + 14 + +
+ + 1933-7205 + + + 2023 + Mar + 14 + + + Reproductive sciences (Thousand Oaks, Calif.) + Reprod Sci + + Higher PAPP-A Values in Pregnant Women Complicated with Preeclampsia Than with Gestational Hypertension. + 10.1007/s43032-023-01176-1 + + The purpose of this study is to compare the levels of maternal serum pregnancy-associated plasma protein-A at the first trimester in pregnancies complicated by impaired placental diseases, such as preeclampsia (PE), intrauterine fetal growth restriction (IUGR), and gestational hypertension (GH), with those in pregnancies without the development of any of these outcomes to expand the knowledge of how this protein behaves in the different impaired placental diseases. This current work is an observational study based on a prospective cohort. Pregnancy-associated plasma protein-A was measured in 422 patients who had completed maternal-perinatal outcomes. Comparisons of pregnancy characteristics and the biomarker between outcome groups (PE, IUGR, gestational hypertension, and not impaired placental outcomes) were analyzed. PAPP-A MoM in the IUGR (0.8 IQR: 0.6-0.9) and GH groups (0.5 IQR: 0.3-1.4) compared to the PE group (1.06 IQR: 0.66-1.52) was significantly lower (p < 0.005). Pregnant women who developed early-onset PE (1.11 IQR 1.08-1.18) presented significant differences with the IUGR group (0.83 IQR: 0.59-0.98; p = 0.002) and those who developed preterm-PE (1.19 IQR: 0.66-1.58; p = 0.045). The results demonstrate that the levels of PAPP-A at first trimester in the sample of women who developed PE, and specially term-PE, were higher than those in women who developed GH or IUGR. The GH group had the lowest PAPP-A values in this sample of pregnant women. Research in a population with a high prevalence of preeclampsia is still lacking and deserves more extended studies to define if these patients could have different rates of PAPP-A. + © 2023. The Author(s). + + + + Uriel + Montserrat + M + http://orcid.org/0000-0001-5987-8633 + + El Bosque Research Group of Maternal Fetal Medicine and Gynecology, Universidad El Bosque, Bogotá, Colombia. urielmonserrat@gmail.com. + + + Ecodiagnóstico El Bosque S.A.S., Bogotá, Colombia. urielmonserrat@gmail.com. + + + Los Cobos Medical Center, Bogotá, Colombia. urielmonserrat@gmail.com. + + + + Romero Infante + Ximena Carolina + XC + http://orcid.org/0000-0002-7040-2705 + + El Bosque Research Group of Maternal Fetal Medicine and Gynecology, Universidad El Bosque, Bogotá, Colombia. + + + Ecodiagnóstico El Bosque S.A.S., Bogotá, Colombia. + + + Los Cobos Medical Center, Bogotá, Colombia. + + + + Rincón Franco + Sara + S + http://orcid.org/0000-0002-4594-9151 + + El Bosque Research Group of Maternal Fetal Medicine and Gynecology, Universidad El Bosque, Bogotá, Colombia. + + + Ecodiagnóstico El Bosque S.A.S., Bogotá, Colombia. + + + + Ibáñez Pinilla + Edgar Antonio + EA + http://orcid.org/0000-0002-9527-9248 + + Research Group of Community Medicine and Collective Health, Universidad El Bosque, Bogotá, Colombia. + + + + Rojas + Nydia Alexandra + NA + http://orcid.org/0000-0002-3688-0375 + + El Bosque Research Group of Maternal Fetal Medicine and Gynecology, Universidad El Bosque, Bogotá, Colombia. + + + + eng + + + PCI-2013-472 + Univesidad El Bosque + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Reprod Sci + 101291249 + 1933-7191 + + IM + + Gestational Hypertension + Hypertensive Disorders of Pregnancy + IUGR + Preeclampsia + Pregnancy-associated Plasma Protein-A (PAPP-a) + +
+ + + + 2022 + 02 + 21 + + + 2023 + 01 + 20 + + + 2023 + 3 + 14 + 12 + 21 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917422 + 10.1007/s43032-023-01176-1 + 10.1007/s43032-023-01176-1 + + + + Khong TY, De Wolf F, Robertson WB, Brosens I. Inadequate maternal vascular response to placentation in pregnancies complicated by pre-eclampsia and by small-for-gestational age infants. Br J Obstet Gynaecol. 1986;93(10):1049–59. + + 10.1111/j.1471-0528.1986.tb07830.x + 3790464 + + + + Panaitescu AM, Akolekar R, Kametas N, Syngelaki A, Nicolaides KH. Impaired placentation in women with chronic hypertension who develop pre-eclampsia. Ultrasound Obstet Gynecol. 2017;50(4):496–500. https://doi.org/10.1002/uog.17517 . + + 10.1002/uog.17517 + 28470791 + + + + Figueras F, Gratacos E, Rial M, Gull I, Krofta L, Lubusky M, et al. 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+ + + 36917417 + + 2023 + 03 + 14 + +
+ + 1433-7339 + + 31 + 4 + + 2023 + Mar + 14 + + + Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer + Support Care Cancer + + Trajectories of participation in daily life among individuals newly diagnosed with cancer: A 5-month longitudinal study. + + 213 + + 10.1007/s00520-023-07672-z + + To determine how participation in daily life is impacted during the first six months following a new cancer diagnosis and to identify risk factors for participation restrictions. Patient-reported outcomes (PROs) were used to suggest referrals to rehabilitation services. + Participants (n = 123) were adults (> 18 years) with the newly diagnosed primary brain, breast, colorectal, or lung cancer. PROs were collected at baseline (within 30 days of diagnosis/treatment initiation), two and five months post baseline. Daily life participation was assessed through the community participation indicators (CPI) (score range: 0-1) and patient-reported outcome measurement information system (PROMIS) ability to participate, (score range: 20-80; mean: 50, SD: 10). PROMIS-43 profile was also completed. Linear mixed-effect models with random intercept evaluated change in participation over time. + The baseline total sample mean CPI score was 0.56; patients reported mildly impaired participation based on PROMIS scores (baseline: 46.19, 2-month follow-up: 44.81, 5 months: 44.84). However, no statistically significant changes in participation were observed over the study period. Risk factors for lower participation included receiving chemotherapy, lower physical function, higher anxiety and fatigue, and reduction in employment, p < 0.05. PROs indicated that roughly half of the participants may benefit from physical or occupational therapy or mental health support, but only 20-36% were referred by their medical team. + People newly diagnosed with cancer experience impaired participation, but they are infrequently referred to supportive services such as rehabilitation. The use of PROs to assess participation, physical function, and mental health can promote access to supportive care services by identifying patients who may benefit from rehabilitation beyond those identified through routine clinical care. + © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. + + + + L'Hotta + Allison J + AJ + + Washington University in St. Louis School of Medicine, 660 S. Euclid Ave., Campus Box 8505-45-01, St. Louis, MO, 63110, USA. alhotta@wustl.edu. + + + + Yan + Yan + Y + + Washington University in St. Louis School of Medicine, 660 S. Euclid Ave., Campus Box 8505-45-01, St. Louis, MO, 63110, USA. + + + + Davis + Andrew A + AA + + Washington University in St. Louis School of Medicine, 660 S. Euclid Ave., Campus Box 8505-45-01, St. Louis, MO, 63110, USA. + + + + Waqar + Saiama N + SN + + Washington University in St. Louis School of Medicine, 660 S. Euclid Ave., Campus Box 8505-45-01, St. Louis, MO, 63110, USA. + + + + Chheda + Milan G + MG + + Washington University in St. Louis School of Medicine, 660 S. Euclid Ave., Campus Box 8505-45-01, St. Louis, MO, 63110, USA. + + + + Tan + Benjamin R + BR + + Washington University in St. Louis School of Medicine, 660 S. Euclid Ave., Campus Box 8505-45-01, St. Louis, MO, 63110, USA. + + + + Lyons + Kathleen D + KD + + Massachusetts General Hospital Institute of Health Professions, Boston, MA, USA. + + + + Park + Yikyung + Y + + Washington University in St. Louis School of Medicine, 660 S. Euclid Ave., Campus Box 8505-45-01, St. Louis, MO, 63110, USA. + + + + King + Allison A + AA + + Washington University in St. Louis School of Medicine & St. Louis Children's Hospital, St. Louis, MO, USA. + + + + eng + + + 1K24HL148305-01 + HL + NHLBI NIH HHS + United States + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Support Care Cancer + 9302957 + 0941-4355 + + IM + + Cancer + Patient-reported outcome measures + Quality of life + Rehabilitation + +
+ + + + 2022 + 08 + 31 + + + 2023 + 03 + 07 + + + 2023 + 3 + 14 + 12 + 21 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917417 + 10.1007/s00520-023-07672-z + 10.1007/s00520-023-07672-z + + + + L’Hotta AJ et al (2022) Cancer survivors’ perspectives of participation: a qualitative analysis. Arch Rehab Res Clin Transl 4:100212. https://doi.org/10.1016/j.arrct.2022.100212 + + 10.1016/j.arrct.2022.100212 + + + + L’Hotta AJ et al (2020) Assessments used to measure participation in life activities in individuals with cancer: a scoping review. Support Care Cancer 28:3581–3592. https://doi.org/10.1007/s00520-020-05441-w + + 10.1007/s00520-020-05441-w + 32285262 + + + + Brick R et al (2022) Impact of non-pharmacological interventions on activity limitations and participation restrictions in older breast cancer survivors: a scoping review. 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+ + + 36917423 + + 2023 + 03 + 14 + +
+ + 1933-7205 + + + 2023 + Mar + 14 + + + Reproductive sciences (Thousand Oaks, Calif.) + Reprod Sci + + Linc-ROR Promotes EMT by Targeting miR-204-5p/SMAD4 in Endometriosis. + 10.1007/s43032-023-01204-0 + + Endometriosis (EMs) is a systemic and chronic disease with cancer-like feature, namely, distant implantation, which caused heavy healthy burden of nearly 200 million females. LncRNAs have been proved as new modulators in epithelial-mesenchymal transition (EMT) and EMs. Quantitative real-time PCR was conducted to measure the expression level of long intergenic non-protein coding RNA, regulator of reprogramming (Linc-ROR), and miR-204-5p in ectopic endometrium (n = 25), eutopic endometrium (n = 20), and natural control endometrium (n = 22). Overexpression of Linc-ROR, knockdown or overexpression of miR-204-5p in End1/E6E7 and Ishikawa cells, was conducted to detect the function of Linc-ROR and miR-204-5p in EMs. Furthermore, luciferase reports were used to confirm the combination of Linc-ROR and miR-204-5p and the combination between miR-204-5p and SMAD4. Cell-Counting Kit-8, EdU assay, transwell assays, and Western blotting were used to detect the function of Linc-ROR and miR-204-5p in EMs cancer-like behaviors and EMT process. Linc-ROR was up-regulated in ectopic endometrium. Overexpressed Linc-ROR promotes cell proliferation, invasion, and EMT process. Linc-ROR regulated the EMT process, cellular proliferation, and invasion of EMs via binding to miR-204-5p. In addition, overexpression of Linc-ROR up-regulated SMAD4, a target protein of miR-204-5p, with which regulated EMT process and cancer-like behaviors in EMs together. Linc-ROR/miR-204-5p/SMAD4 axis plays a vital role in regulation EMT process in EMs, which might become a novel therapeutic targets and powerful biomarkers in EMs therapy. + © 2023. The Author(s), under exclusive licence to Society for Reproductive Investigation. + + + + Yi + Mingyu + M + + Department of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, NO.139 Middle Renmin Road, Changsha, 410011, Hunan, China. + + + + Wang + Sixue + S + + Department of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, NO.139 Middle Renmin Road, Changsha, 410011, Hunan, China. + + + + Zhang + Xinyue + X + + Department of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, NO.139 Middle Renmin Road, Changsha, 410011, Hunan, China. + + + + Jiang + Li + L + + Department of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, NO.139 Middle Renmin Road, Changsha, 410011, Hunan, China. + + + + Xia + Xiaomeng + X + + Department of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, NO.139 Middle Renmin Road, Changsha, 410011, Hunan, China. + + + + Zhang + Tingting + T + + Department of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, NO.139 Middle Renmin Road, Changsha, 410011, Hunan, China. + + + + Fang + Xiaoling + X + http://orcid.org/0000-0001-6005-9598 + + Department of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, NO.139 Middle Renmin Road, Changsha, 410011, Hunan, China. fxlfxl0510@csu.edu.cn. + + + + eng + + + Nos.81671437 + the National Natural Science Foundation of China + + + + 81771558 + the National Natural Science Foundation of China + + + + Nos. 2016JC2049 + the Natural Science Foundation of Hunan Province + + + + 2020JJ4814 + the Natural Science Foundation of Hunan Province + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Reprod Sci + 101291249 + 1933-7191 + + IM + + EMT + Endometriosis + Linc-ROR + SMAD4 + ceRNA + miR-204-5p + +
+ + + + 2022 + 01 + 20 + + + 2023 + 02 + 17 + + + 2023 + 3 + 14 + 12 + 21 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917423 + 10.1007/s43032-023-01204-0 + 10.1007/s43032-023-01204-0 + + + + Eisenberg VH, Weil C, Chodick G, Shalev V. Epidemiology of endometriosis: a large population-based database study from a healthcare provider with 2 million members. BJOG. 2018;125:55–62. + + 28444957 + 10.1111/1471-0528.14711 + + + + de Ziegler D, Borghese B, Chapron C. Endometriosis and infertility: pathophysiology and management. Lancet. 2010;376:730–8. + + 20801404 + 10.1016/S0140-6736(10)60490-4 + + + + Bulun SE, Yilmaz BD, Sison C, Miyazaki K, Bernardi L, Liu S, Kohlmeier A, Yin P, Milad M, Wei J. Endometriosis. 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+ + + 36917419 + + 2023 + 03 + 14 + +
+ + 1559-1182 + + + 2023 + Mar + 14 + + + Molecular neurobiology + Mol Neurobiol + + Sex and the Estrous-Cycle Phase Influence the Expression of G Protein-Coupled Estrogen Receptor 1 (GPER) in Schizophrenia: Translational Evidence for a New Target. + 10.1007/s12035-023-03295-x + + Schizophrenia is a mental disorder with sex bias in disease onset and symptom severity. Recently, it was observed that females present more severe symptoms in the perimenstrual phase of the menstrual cycle. The administration of estrogen also alleviates schizophrenia symptoms. Despite this, little is known about symptom fluctuation over the menstrual cycle and the underlying mechanisms. To address this issue, we worked with the two-hit schizophrenia animal model induced by neonatal exposure to a virus-like particle, Poly I:C, associated with peripubertal unpredictable stress exposure. Prepulse inhibition of the startle reflex (PPI) in male and female mice was considered analogous to human schizophrenia-like behavior. Female mice were studied in the proestrus (high-estrogen estrous cycle phase) and diestrus (low-estrogen phase). Additionally, we evaluated the hippocampal mRNA expression of estrogen synthesis proteins; TSPO and aromatase; and estrogen receptors ERα, ERβ, and GPER. We also collected peripheral blood mononuclear cells (PBMCs) from male and female patients with schizophrenia and converted them to induced microglia-like cells (iMGs) to evaluate the expression of GPER. We observed raised hippocampal expression of GPER in two-hit female mice at the proestrus phase without PPI deficits and higher levels of proteins related to estrogen synthesis, TSPO, and aromatase. In contrast, two-hit adult males with PPI deficits presented lower hippocampal mRNA expression of TSPO, aromatase, and GPER. iMGs from male and female patients with schizophrenia showed lower mRNA expression of GPER than controls. Therefore, our results suggest that GPER alterations constitute an underlying mechanism for sex influence in schizophrenia. + © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. + + + + da Silva + Francisco Eliclécio Rodrigues + FER + + Drug Research and Development Center, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara, Rua Cel. Nunes de Melo 1000, 60430-275, CE, Fortaleza, Brazil. + + + + Cordeiro + Rafaela Carneiro + RC + + Drug Research and Development Center, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara, Rua Cel. Nunes de Melo 1000, 60430-275, CE, Fortaleza, Brazil. + + + University of Texas Health Science Center at Houston, Houston, USA. + + + + de Carvalho Lima + Camila N + CN + + Drug Research and Development Center, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara, Rua Cel. Nunes de Melo 1000, 60430-275, CE, Fortaleza, Brazil. + + + University of Texas Health Science Center at Houston, Houston, USA. + + + + Cardozo + Pablo Leal + PL + + Department of Biochemistry and Immunology, Institute of Biological Sciences (ICB), Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. + + + + Vasconcelos + Germana Silva + GS + + Drug Research and Development Center, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara, Rua Cel. Nunes de Melo 1000, 60430-275, CE, Fortaleza, Brazil. + + + + Monte + Aline Santos + AS + + Health Science Institute, University of International Integration of Afro-Brazilian Lusophony UNILAB, Redenção, Brazil. + + + + Sanders + Lia Lira Olivier + LLO + + Course of Medicine, Centro Universitário Christus-Unichristus, Fortaleza, Brazil. + + + Department of Clinical Medicine, Federal University of Ceara, Fortaleza, Brazil. + + + + Vasconcelos + Silvânia Maria Mendes + SMM + + Drug Research and Development Center, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara, Rua Cel. Nunes de Melo 1000, 60430-275, CE, Fortaleza, Brazil. + + + + de Lucena + David Freitas + DF + + Drug Research and Development Center, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara, Rua Cel. Nunes de Melo 1000, 60430-275, CE, Fortaleza, Brazil. + + + + Cruz + Breno Fiuza + BF + + Department of Mental Health, Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. + + + + Nicolato + Rodrigo + R + + Department of Mental Health, Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. + + + + Seeman + Mary V + MV + + Department of Psychiatry, University of Toronto, Toronto, Canada. + + + + Ribeiro + Fabíola Mara + FM + + Department of Biochemistry and Immunology, Institute of Biological Sciences (ICB), Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. + + + + Macedo + Danielle S + DS + http://orcid.org/0000-0001-8980-9970 + + Drug Research and Development Center, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara, Rua Cel. Nunes de Melo 1000, 60430-275, CE, Fortaleza, Brazil. danielle.macedo@ufc.br. + + + National Institute for Translational Medicine (INCT-TM, CNPq), São Paulo, Brazil. danielle.macedo@ufc.br. + + + + eng + + + 466724/2014-4 + Conselho Nacional de Desenvolvimento Científico e Tecnológico + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Mol Neurobiol + 8900963 + 0893-7648 + + IM + + GPER1 + Induced microglia-like cells + Schizophrenia + Sex differences + Two-hit animal model + +
+ + + + 2022 + 09 + 09 + + + 2023 + 02 + 24 + + + 2023 + 3 + 14 + 12 + 21 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917419 + 10.1007/s12035-023-03295-x + 10.1007/s12035-023-03295-x + + + References + + Li R, Ma X, Wang G et al (2016) Why sex differences in schizophrenia? J Transl Neurosci (Beijing) 1:37–42 + + 29152382 + + + + Nawka A, Kalisova L, Raboch J et al (2013) Gender differences in coerced patients with schizophrenia. BMC Psychiatry 13:257. https://doi.org/10.1186/1471-244X-13-257 + + 10.1186/1471-244X-13-257 + 24118928 + 3852852 + + + + Gogos A, Van den Buuse M (2015) Comparing the effects of 17β-oestradiol and the selective oestrogen receptor modulators, raloxifene and tamoxifen, on prepulse inhibition in female rats. 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+ + + 36917420 + + 2023 + 03 + 14 + +
+ + 1720-8386 + + + 2023 + Mar + 14 + + + Journal of endocrinological investigation + J Endocrinol Invest + + High levels of LIGHT/TNFSF14 in patients with Prader-Willi syndrome. + 10.1007/s40618-023-02050-2 + + Prader-Willi syndrome (PWS) is a rare genetic disorder displaying different clinical features, including obesity and bone impairment. LIGHT/TNFSF14 is a cytokine produced by immune cells affecting both fat and bone metabolism. The present study aimed to evaluate LIGHT serum levels in 28 children and 52 adult PWS patients compared to age and sex-matched controls, as well as correlations with parameters of bone and fat metabolism. + Median serum LIGHT levels were significantly increased in pediatric PWS with respect to controls [255.82 (284.43) pg/ml vs 168.11 (76.23) pg/ml, p ≤ 0.02] as well as in adult PWS compared to controls [296.85 (895.95) pg/ml vs 134.18 (141.18) pg/ml, p ≤ 0.001]. In pediatric PWS, LIGHT levels were positively correlated with weight-SDS, height-SDS, and glucose levels, and negatively with total 25 (OH) vitamin D, cholesterol, LDL cholesterol and triglycerides. Additionally, LIGHT levels were negatively correlated with total BMD and fat mass. In adult PWS, LIGHT levels were positively correlated with weight, HDL cholesterol and PTH, and negatively with glucose, insulin, HOMA-IR, total cholesterol, LDL cholesterol, triglycerides, calcium, phosphorus, 25(OH)Vitamin D as well as with instrumental parameters of bone and fat quality. Consistently, multiple regression analysis showed that LIGHT serum levels in pediatric and adult PWS were predicted by different parameters including 25 (OH) Vitamin D as well as DXA parameters of bone and fat quality. + In PWS children and adults the high levels of LIGHT could represent a marker of the altered bone and fat metabolism. + © 2023. The Author(s). + + + + Faienza + M F + MF + + Department of Precision and Regenerative Medicine and Ionian Area, Section of Human Anatomy and Histology, University of Bari 'A. Moro', Bari, Italy. + + + + Brunetti + G + G + http://orcid.org/0000-0002-0681-1432 + + Department of Biosciences, Biotechnologies and Environment, University of Bari Aldo Moro, Via Orabona, 4, 70125, Bari, Italy. giacomina.brunetti@uniba.it. + + + + Fintini + D + D + + Endocrinology Unit, Pediatric University Department, Bambino Gesù Children's Hospital, Rome, Italy. + + + + Grugni + G + G + + Division of Auxology, Istituto Auxologico Italiano, Research Institute, Verbania, Italy. + + + + Wasniewska + M G + MG + + Pediatric Unit, Department of Human Pathology in Adulthood and Childhood, University of Messina, Messina, Italy. + + + + Crinò + A + A + + Reference Center for Prader-Willi Syndrome, Bambino Gesù Children's Hospital, Research Institute, Rome, Italy. + + + + D'Amato + G + G + + Neonatal Intensive Care Unit, Di Venere Hospital, Bari, Italy. + + + + Piacente + L + L + + Department of Precision and Regenerative Medicine and Ionian Area, Section of Human Anatomy and Histology, University of Bari 'A. Moro', Bari, Italy. + + + + Oranger + A + A + + Department of Precision and Regenerative Medicine and Ionian Area, Section of Human Anatomy and Histology, University of Bari 'A. Moro', Bari, Italy. + + + + Dicarlo + M + M + + Department of Translational Biosciences and Neurosciences, Section of Human Anatomy and Histology, University of Bari 'A. Moro', Bari, Italy. + + + + Colucci + S + S + + Department of Translational Biosciences and Neurosciences, Section of Human Anatomy and Histology, University of Bari 'A. Moro', Bari, Italy. + + + + Grano + M + M + + Department of Precision and Regenerative Medicine and Ionian Area, Section of Human Anatomy and Histology, University of Bari 'A. Moro', Bari, Italy. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Italy + J Endocrinol Invest + 7806594 + 0391-4097 + + IM + + Bone disease + DXA + LIGHT/TNFSF14 + Prader–Willi syndrome + +
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+ + + 36917426 + + 2023 + 03 + 14 + +
+ + 1573-3254 + + + 2023 + Mar + 14 + + + AIDS and behavior + AIDS Behav + + Examining the Relationship Between HIV-Related Stigma and the Health and Wellbeing of Children and Adolescents Living with HIV: A Systematic Review. + 10.1007/s10461-023-04034-y + + Human immunodeficiency virus (HIV) affects millions of people globally. The associated stigma remains a challenge for individuals living with HIV and children and adolescents face the additional challenge of withstanding the peer, pubertal and identity challenges associated with growing up. The current systematic review aimed to define and explore the major stigma-related challenges of children and adolescents from their own perspectives. A secondary aim was to identify any challenges distinct to childhood and adolescence. Studies included individuals aged 3 to 18 years who were aware of their status. Fifteen studies met inclusion criteria. Narrative synthesis was conducted on the included studies. Five analytic themes emerged describing major stigma-related challenges: disclosure-related anxiety, medication adherence, feelings of abnormality, mental health issues and social exclusion. Disclosure-related anxiety and feelings of abnormality appeared to be largely confined to the experience of children and adolescents. Many of the themes centred around peer influence, highlighting the need to belong in youth. Results suggest that youth require tailored interventions targeting their age-specific challenges. + © 2023. The Author(s). + + + + Robinson + Abbie + A + http://orcid.org/0000-0002-7882-1605 + + School of Psychology, Dublin City University, Dublin, Ireland. abbie.robinson26@mail.dcu.ie. + + + + Cooney + Aoife + A + + School of Psychology, Dublin City University, Dublin, Ireland. + + + + Fassbender + Catherine + C + + School of Psychology, Dublin City University, Dublin, Ireland. + + + + McGovern + David P + DP + + School of Psychology, Dublin City University, Dublin, Ireland. + + + + eng + + Journal Article + Review + + + 2023 + 03 + 14 + +
+ + United States + AIDS Behav + 9712133 + 1090-7165 + + IM + + Human immunodeficiency virus (HIV) + children and adolescents + stigma + wellbeing + +
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+ + + 36917427 + + 2023 + 03 + 14 + +
+ + 1573-7365 + + + 2023 + Mar + 14 + + + Metabolic brain disease + Metab Brain Dis + + Ferrous sulfate reverses cerebral metabolic abnormality induced by minimal hepatic encephalopathy. + 10.1007/s11011-023-01198-3 + + Orally administered ferrous iron was previously reported to significantly improve the cognition and locomotion of patients with minimal hepatic encephalopathy (MHE). However, the metabolic mechanisms of the therapeutic effect of ferrous iron are unknown. In this study, MHE was induced in rats by partial portal vein ligation (PPVL), and was treated with ferrous sulfate. The Morris water maze was used to evaluate the cognitive condition of the rats. The metabolites observed by NMR and validated by liquid chromatography-mass spectrometry were defined as the key affected metabolites. The enzyme activities and trace element contents in the rat brains were also investigated. The Mn content was found to be increased but the ferrous iron content decreased in the cortex and striatum in MHE. Decreased oxoglutarate dehydrogenase activity and increased glutamine synthetase (GS) and pyruvate carboxylase (PC) activity were observed in the cortex of MHE rats. Decreased pyruvate dehydrogenase activity and increased GS and PC activity were observed in the striatum of MHE rats. The levels of BCAAs and taurine were significantly decreased, and the contents of GABA, lactate, arginine, aspartate, carnosine, citrulline, cysteine, glutamate, glutamine, glycine, methionine, ornithine, proline, threonine and tyrosine were significantly increased. These metabolic abnormalities described above were restored after treatment with ferrous sulfate. Pathway enrichment analysis suggested that urea cycle, aspartate metabolism, arginine and proline metabolism, glycine and serine metabolism, and glutamate metabolism were the major metabolic abnormalities in MHE rats, but these processes could be restored and cognitive impairment could be improved by ferrous sulfate administration. + © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. + + + + Liu + Xue-Fei + XF + http://orcid.org/0000-0001-7796-6805 + + Department of Radiology, Jinshan Hospital, Fudan University, Shanghai, 201508, China. + + + + Lu + Jing-Jing + JJ + http://orcid.org/0000-0003-1434-7809 + + Department of Radiology, Jinshan Hospital, Fudan University, Shanghai, 201508, China. + + + + Li + Ying + Y + http://orcid.org/0000-0001-5062-0230 + + Department of Radiology, Jinshan Hospital, Fudan University, Shanghai, 201508, China. dr.yingli@foxmail.com. + + + + Yang + Xiu-Ying + XY + http://orcid.org/0000-0002-9106-4098 + + Department of Radiology, Jinshan Hospital, Fudan University, Shanghai, 201508, China. + + + + Qiang + Jin-Wei + JW + http://orcid.org/0000-0002-6327-1401 + + Department of Radiology, Jinshan Hospital, Fudan University, Shanghai, 201508, China. dr.jinweiqiang@163.com. + + + + eng + + + 2021-3-01 + inshan Science and Technology Committee + + + + No. ZK2019B01 + Shanghai Municipal Health Commission + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Metab Brain Dis + 8610370 + 0885-7490 + + IM + + Ferrous sulfate; Manganese + Liquid chromatography + Magnetic resonance spectroscopy + Minimal hepatic encephalopathy + +
+ + + + 2022 + 05 + 12 + + + 2023 + 03 + 03 + + + 2023 + 3 + 14 + 12 + 21 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917427 + 10.1007/s11011-023-01198-3 + 10.1007/s11011-023-01198-3 + + + + Amos-Kroohs RM, Davenport LL, Atanasova N, Abdulla ZI, Skelton MR, Vorhees CV, Williams MT (2017) Developmental manganese neurotoxicity in rats: cognitive deficits in allocentric and egocentric learning and memory. Neurotoxicol Teratol 59:16–26. https://doi.org/10.1016/j.ntt.2016.10.005 + + 10.1016/j.ntt.2016.10.005 + 27756629 + + + + Bosoi CR, Rose CF (2013) Brain edema in acute liver failure and chronic liver disease: similarities and differences. Neurochem Int 62. https://doi.org/10.1016/j.neuint.2013.01.015 . :446 – 57 + + + Bosoi CR, Rose CF (2014) Elevated cerebral lactate: implications in the pathogenesis of hepatic encephalopathy. 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+ + + 36917424 + + 2023 + 03 + 14 + +
+ + 1573-3254 + + + 2023 + Mar + 14 + + + AIDS and behavior + AIDS Behav + + A Psychometric Evaluation and a Framework Test of the HIV Stigma Mechanisms Scale Among a Population-Based Sample of Men and Women Living with HIV in Central Uganda. + 10.1007/s10461-023-04026-y + + HIV stigma is a critical barrier to HIV prevention and care. This study evaluates the psychometric properties of the HIV Stigma Mechanisms Scale (HIV-SMS) among people living with HIV (PLHIV) in central Uganda and tests the underlying framework. Using data from the PATH/Ekkubo study, (n = 804 PLHIV), we assessed the HIV-SMS' reliability and validity (face, content, construct, and convergent). We used multiple regression analyses to test the HIV-SMS' association with health and well-being outcomes. Findings revealed a more specific (5-factor) stigma structure than the original model, splitting anticipated and enacted stigmas into two subconstructs: family and healthcare workers (HW). The 5-factor model had high reliability (α = 0.92-0.98) and supported the convergent validity (r = 0.12-0.42, p < 0.01). The expected relationship between HIV stigma mechanisms and health outcomes was particularly strong for internalized stigma. Anticipated-family and enacted-family stigma mechanisms showed partial agreement with the hypothesized health outcomes. Anticipated-HW and enacted-HW mechanisms showed no significant association with health outcomes. The 5-factor HIV-SMS yielded a proper and nuanced measurement of HIV stigma in central Uganda, reflecting the importance of family-related stigma mechanisms and showing associations with health outcomes similar to and beyond the seminal study. + © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. + + + + Almeida + Alexandra + A + + Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, CA, USA. + + + School of Social Work, College of Health and Human Services, San Diego State University, San Diego, CA, USA. + + + Programa de Computação Científica, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil. + + + + Ogbonnaya + Ijeoma Nwabuzor + IN + + School of Social Work, Watts College of Public Service and Community Solutions, Arizona State University, Phoenix, AZ, USA. + + + + Wanyenze + Rhoda K + RK + + Department of Disease Control and Environmental Health, School of Public Health, Makerere University, Kampala, Uganda. + + + + Crockett + Katherine Schmarje + KS + + Division of Epidemiology and Biostatistics, School of Public Health, San Diego State University, 5500 Campanile Drive (MC-4162), San Diego, CA, 92182, USA. + + + The Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, USA. + + + + Ediau + Michael + M + + Division of Epidemiology and Biostatistics, School of Public Health, San Diego State University, 5500 Campanile Drive (MC-4162), San Diego, CA, 92182, USA. + + + The Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, USA. + + + + Naigino + Rose + R + + Division of Epidemiology and Biostatistics, School of Public Health, San Diego State University, 5500 Campanile Drive (MC-4162), San Diego, CA, 92182, USA. + + + The Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, USA. + + + + Lin + Chii-Dean + CD + + Department of Mathematics & Statistics, San Diego State University, La Jolla, CA, USA. + + + + Kiene + Susan M + SM + http://orcid.org/0000-0001-8922-5289 + + Department of Disease Control and Environmental Health, School of Public Health, Makerere University, Kampala, Uganda. skiene@sdsu.edu. + + + Division of Epidemiology and Biostatistics, School of Public Health, San Diego State University, 5500 Campanile Drive (MC-4162), San Diego, CA, 92182, USA. skiene@sdsu.edu. + + + + eng + + + 5R01MH106391 + MH + NIMH NIH HHS + United States + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + AIDS Behav + 9712133 + 1090-7165 + + IM + + HIV + Scale + Stigma + Sub-Saharan Africa + Uganda + +
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+ + + 36917425 + + 2023 + 03 + 14 + +
+ + 1573-3254 + + + 2023 + Mar + 14 + + + AIDS and behavior + AIDS Behav + + Agreements, Behaviour, and Change: Sex Outside the Relationship in Male HIV-negative Partners in HIV Serodiscordant Relationships in Australia, Brazil, and Thailand. + 10.1007/s10461-023-04030-2 + + Male HIV serodiscordant couples have diverse relationship agreements regarding sex outside the relationship. We examined the relationship agreements as described by 343 male HIV-negative partners in HIV serodiscordant relationships in Australia, Brazil and Thailand participating in a multi-year cohort study. At baseline, 125 (34.1%) HIV-negative partners reported no agreement, 115 (33.5%) had a monogamous agreement, and 103 (37.9%) had an open agreement allowing sex outside the relationship. Relationship agreements were largely stable over time, with 76% of HIV-negative men reporting the same agreement across follow up, while changes were predominantly towards having an open agreement. Behaviour largely matched relationship agreements, and the predictors of breaking an agreement by having condomless anal intercourse (CLAI) with an outside partner were CLAI within the relationship (OR = 3.17, 95%CI: 1.64-6.14, p < 0.001) and PrEP use in the last three months (OR = 3.42, 95%CI: 1.48-7.92, p = 0.004). When considering HIV transmission risk for HIV-negative men in serodiscordant relationships, greater focus needs to be placed on sex that is occurring outside the relationship and the agreements that facilitate this. + © 2023. The Author(s). + + + + Gray + James + J + http://orcid.org/0000-0001-7090-293X + + The Kirby Institute, UNSW Sydney, Sydney, NSW, 2052, Australia. jgray@kirby.unsw.edu.au. + + + + Prestage + Garrett + G + + The Kirby Institute, UNSW Sydney, Sydney, NSW, 2052, Australia. + + + + Jin + Fengyi + F + + The Kirby Institute, UNSW Sydney, Sydney, NSW, 2052, Australia. + + + + Phanuphak + Nittaya + N + + Institute of HIV Research and Innovation, Bangkok, Thailand. + + + + Friedman + Ruth K + RK + + Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil. + + + + Fairley + Christopher K + CK + + Melbourne Sexual Health Centre, Melbourne, Australia. + + + Central Clinical School, Monash University, Melbourne, Australia. + + + + Kelleher + Anthony + A + + The Kirby Institute, UNSW Sydney, Sydney, NSW, 2052, Australia. + + + + Templeton + David J + DJ + + The Kirby Institute, UNSW Sydney, Sydney, NSW, 2052, Australia. + + + Department of Sexual Health Medicine and Sexual Assault Medical Service, Sydney Local Health District, Camperdown, Australia. + + + Discipline of Medicine, Central Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia. + + + + Zablotska-Manos + Iryna + I + + Westmead Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, Australia. + + + Western Sydney Sexual Health, Western Sydney Local Health District, Sydney, Australia. + + + + Hoy + Jennifer + J + + Department of Infectious Diseases, Alfred Hospital, Monash University, Melbourne, Australia. + + + + McNulty + Anna + A + + Sydney Sexual Health Centre, Sydney and Sydney Eye Hospital, Sydney, Australia. + + + School of Population Health, UNSW Sydney, Sydney, Australia. + + + + Baker + David + D + + East Sydney Doctors, Sydney, Australia. + + + + Brown + Graham + G + + Centre for Social Impact, UNSW Sydney, Sydney, Australia. + + + + Grulich + Andrew + A + + The Kirby Institute, UNSW Sydney, Sydney, NSW, 2052, Australia. + + + + Bavinton + Benjamin + B + + The Kirby Institute, UNSW Sydney, Sydney, NSW, 2052, Australia. + + + + Opposites Attract study group + + + eng + + + National Health and Medical Research Council + National Health and Medical Research Council + + + + amfAR, The Foundation for AIDS Research + amfAR, The Foundation for AIDS Research + + + + Gilead Sciences + Gilead Sciences + + + + ViiV Healthcare + ViiV Healthcare + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + AIDS Behav + 9712133 + 1090-7165 + + IM + + Gay men + HIV prevention + Homosexual + Men who have sex with men + Risk reduction strategies + Serodiscordant couples + Sexual behavior + +
+ + + + 2023 + 02 + 20 + + + 2023 + 3 + 14 + 12 + 21 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917425 + 10.1007/s10461-023-04030-2 + 10.1007/s10461-023-04030-2 + + + + World Health Organization. Guideline on when to start antiretroviral therapy and on pre-exposure prophylaxis for HIV. Geneva, Switzerland: World Health Organization; 2015. + + + Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, Kumarasamy N, et al. Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med. 2011;365(6):493–505. + + 10.1056/NEJMoa1105243 + 21767103 + 3200068 + + + + Bavinton BR, Pinto AN, Phanuphak N, Grinsztejn B, Prestage GP, Zablotska-Manos IB, et al. Viral suppression and HIV transmission in serodiscordant male couples: an international, prospective, observational, cohort study. Lancet HIV. 2018;5(8):e438–e47. + + 10.1016/S2352-3018(18)30132-2 + 30025681 + + + + Rodger AJ, Cambiano V, Bruun T, Vernazza P, Collins S, Degen O, et al. 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Intimacy and sexual risk behaviour in serodiscordant male couples. AIDS Care. 1995;7(4):429–38. + + 10.1080/09540129550126380 + 8547358 + + + + Bavinton BR, Hammoud MA, Holt M, Saxton P, Bourne A, MacGibbon J et al. Changes in sexual behaviour following PrEP initiation among Australian gay and bisexual men in relationships: Results from a prospective observational study.AIDS Behav. 2021. + + + MacGibbon J, Broady T, Drysdale K, Bavinton B, Lee E, Mao L, et al. Gay men’s relationship agreements in the era of pre-exposure prophylaxis: an analysis of australian behavioural surveillance data. AIDS Behav. 2020;24(5):1389–99. + + 10.1007/s10461-019-02737-9 + 31745684 + + + + Bavinton BR, Jin F, Prestage G, Zablotska I, Koelsch KK, Phanuphak N, et al. The Opposites attract study of viral load, HIV treatment and HIV transmission in serodiscordant homosexual male couples: design and methods. BMC Public Health. 2014;14:917. + + 10.1186/1471-2458-14-917 + 25190360 + 4168197 + + + + Bavinton BR, Prestage GP, Jin F, Phanuphak N, Grinsztejn B, Fairley CK, et al. Strategies used by gay male HIV serodiscordant couples to reduce the risk of HIV transmission from anal intercourse in three countries. J Int AIDS Soc. 2019;22(4):e25277. + + 10.1002/jia2.25277 + 30983155 + 6462805 + + + + John SA, Starks TJ, Rendina HJ, Grov C, Parsons JT. Should I convince my partner to go on pre-exposure prophylaxis (PrEP)? The role of personal and relationship factors on PrEP-related social control among gay and bisexual men. AIDS Behav. 2018;22(4):1239–52. + + 10.1007/s10461-017-1835-1 + 28634660 + 5738299 + + + + Duncan D, Prestage G, Grierson J. Trust, commitment, love and sex: HIV, monogamy, and gay men. J Sex Marital Ther. 2015;41(4):345–60. + + 10.1080/0092623X.2014.915902 + 24754324 + + + + Starks TJ, Jones SS, Kyre K, Robles G, Cain D, Jimenez R, et al. Testing the drug use and condomless anal sex link among sexual minority men: the predictive utility of marijuana and interactions with relationship status. Drug Alcohol Depend. 2020;216:108318. + + 10.1016/j.drugalcdep.2020.108318 + 33022531 + 7959658 + + + + Horvath KJ, Smolenski D, Iantaffi A, Grey JA, Rosser BS. Discussions of viral load in negotiating sexual episodes with primary and casual partners among men who have sex with men. AIDS Care. 2012;24(8):1052–5. + + 10.1080/09540121.2012.668168 + 22519740 + 3389168 + + + + +
+ + + 36917436 + + 2023 + 03 + 14 + +
+ + 1348-2246 + + + 2023 + Mar + 14 + + + Analytical sciences : the international journal of the Japan Society for Analytical Chemistry + Anal Sci + + A rapid and convenient enzyme digestion method for the analysis of N-glycans using exoglycosidase-impregnated polyacrylamide gels fabricated in an automatic pipette tip. + 10.1007/s44211-023-00314-8 + + Efficient enzymatic digestion methods are critical for the characterization and identification of glycans. Glycan hydrolysis enzymes are widely utilized for the identification of glycoprotein or glycolipid glycans. The commonly utilized in solution glycan hydrolysis methods require several hours of incubation with enzymes for complete removal of their target monosaccharides. To develop an efficient and simple method for the rapid release of monosaccharides from glycoprotein glycans, we fabricated exoglycosidase-impregnated acrylamide gels in an automatic pipette tip. Our automated enzymatic reactors are based on the simple photochemical copolymerization of monomers comprising acrylamide and methylene-bis-acrylamide-containing enzymes with an azobis compound functioning as the photocatalytic initiator. After filling the tip of the automatic pipette with these acrylamide solutions, polymerization of the acrylamide gel solution was performed by irradiation with a LED. The immobilized enzymes maintained their activities in the pipette tips and their action was completed by fully automatic pipetting for 10 to 30 min. We utilized 8-aminopyrene-1, 3, 6-trisulfonic acid (APTS)-labeled glycans as a substrate and measured by capillary electrophoresis (CE) before and after enzymatic digestion. We demonstrated that this method exhibited quantitative enzymatic and specific cleavage of monosaccharides from glycoprotein glycans. + © 2023. The Author(s), under exclusive licence to The Japan Society for Analytical Chemistry. + + + + Yamamoto + Sachio + S + http://orcid.org/0000-0002-2354-9413 + + Faculty of Pharmaceutical Sciences, Kindai University, 3-4-1, Kowakae, Higashi-osaka, Osaka, 577-8502, Japan. yamamoto@phar.kindai.ac.jp. + + + + Kato + Naho + N + + Faculty of Pharmaceutical Sciences, Kindai University, 3-4-1, Kowakae, Higashi-osaka, Osaka, 577-8502, Japan. + + + + Wada + Miki + M + + Faculty of Pharmaceutical Sciences, Kindai University, 3-4-1, Kowakae, Higashi-osaka, Osaka, 577-8502, Japan. + + + + Kinoshita + Mitsuhiro + M + + Faculty of Pharmaceutical Sciences, Kindai University, 3-4-1, Kowakae, Higashi-osaka, Osaka, 577-8502, Japan. + + + Antiaging Center, Kindai University, 3-4-1, Kowakae, Higashi-osaka, Osaka, 577-8502, Japan. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Switzerland + Anal Sci + 8511078 + 0910-6340 + + IM + + Acrylamide + Enzyme digestion + Glycan + Glycoprotein + Pipette tips + +
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+ + + 36917421 + + 2023 + 03 + 14 + +
+ + 1720-8386 + + + 2023 + Mar + 14 + + + Journal of endocrinological investigation + J Endocrinol Invest + + SARS-CoV-2 and male infertility: from short- to long-term impacts. + 10.1007/s40618-023-02055-x + + The coronavirus 2019 (COVID-19) pandemic-caused by a new type of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-has posed severe impacts on public health worldwide and has resulted in a total of > 6 million deaths. Notably, male patients developed more complications and had mortality rates ~ 77% higher than those of female patients. The extensive expression of the SARS-CoV-2 receptor and related proteins in the male reproductive tract and the association of serum testosterone levels with viral entry and infection have brought attention to COVID-19's effects on male fertility. + The peer-reviewed articles and reviews were obtained by searching for the keywords SARS-CoV-2, COVID-19, endocrine, spermatogenesis, epididymis, prostate, and vaccine in the databases of PubMed, Web of Science and Google Scholar from 2020-2022. + This review summarizes the effects of COVID-19 on the male reproductive system and investigates the impact of various types of SARS-CoV-2 vaccines on male reproductive health. We also present the underlying mechanisms by which SARS-CoV-2 affects male reproduction and discuss the potentially harmful effects of asymptomatic infections, as well as the long-term impact of COVID-19 on male reproductive health. + COVID-19 disrupted the HPG axis, which had negative impacts on spermatogenesis and the epididymis, albeit further investigations need to be performed. The development of vaccines against various SARS-CoV-2 variations is important to lower infection rates and long-term COVID risks. + © 2023. The Author(s), under exclusive licence to Italian Society of Endocrinology (SIE). + + + + Dai + P + P + + Institute of Reproductive Medicine, Medical School of Nantong University, Nantong, People's Republic of China. + + + + Qiao + F + F + + Institute of Reproductive Medicine, Medical School of Nantong University, Nantong, People's Republic of China. + + + + Chen + Y + Y + + Institute of Reproductive Medicine, Medical School of Nantong University, Nantong, People's Republic of China. + + + + Chan + D Y L + DYL + + Assisted Reproductive Technologies Unit, Department of Obstetrics and Gynecology, The Chinese University of Hong Kong, Hong Kong, People's Republic of China. + + + + Yim + H C H + HCH + + Microbiome Research Centre, School of Clinical Medicine, Faculty of Medicine, St George and Sutherland Campus, UNSW Sydney, Sydney, Australia. + + + + Fok + K L + KL + + School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, People's Republic of China. ellisfok@cuhk.edu.hk. + + + Kong Joint Laboratory for Reproductive Medicine, Sichuan University-The Chinese University of Hong, West China Second University Hospital, Chengdu, People's Republic of China. ellisfok@cuhk.edu.hk. + + + + Chen + H + H + http://orcid.org/0000-0001-8319-8101 + + Institute of Reproductive Medicine, Medical School of Nantong University, Nantong, People's Republic of China. chenhao@ntu.edu.cn. + + + + eng + + + 81871202 + National Natural Science Foundation of China + + + + + Journal Article + Review + + + 2023 + 03 + 14 + +
+ + Italy + J Endocrinol Invest + 7806594 + 0391-4097 + + IM + + Epididymis + Male infertility + SARS-CoV-2 + Testis + +
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+ + + 36917428 + + 2023 + 03 + 14 + +
+ + 1865-8652 + + + 2023 + Mar + 14 + + + Advances in therapy + Adv Ther + + Concept Elicitation Interviews and Conceptual Model to Understand the Patient Experience of Limb Girdle Muscular Dystrophy. + 10.1007/s12325-023-02463-8 + + Limb girdle muscular dystrophies (LGMDs) are a group of rare and heterogeneous disorders involving progressive wasting of shoulder and pelvic girdle musculature. This study aimed to generate qualitative evidence on patient and caregiver experiences with symptoms and impacts of LGMD on overall function and daily life for sarcoglycanopathy subtypes 2C/R5, 2D/R3, and 2E/R4. + Twenty-three individuals with LGMD with (n = 5) or without (n = 18) a caregiver participated in 60-minute semi-structured video interviews. Interview transcripts were analyzed using thematic analysis. Differences in patient experience by ambulation status and LGMD subtype were examined. + Participants were ambulatory (n = 14) and non-ambulatory (n = 9), representing three subtypes: 2C/R5 (n = 4), 2D/R3 (n = 12), and 2E/R4 (n = 7), with mean age of 34.8 years (SD = 16.08). 56.5% identified as female. Conceptual saturation was achieved within 18/23 interviews. Ambulatory participants identified difficulty with complex physical activities, e.g., running (n = 11, 78.6%), physical strength (n = 14, 100%), and difficulty with transfers, e.g., difficulty getting off the floor (n = 10, 71.4%). All non-ambulatory participants discussed problems with activities of daily living (ADLs) and transfers, e.g., getting in/out of bed and upper extremity function, particularly reaching (n = 8, 88.9%) and fine motor skills (n = 6, 66.7%). Fatigue and pain were reported by the majority of participants (n = 16, 69.6% and n = 19, 82.6%, respectively). A conceptual disease model was developed illustrating symptoms and impacts and their relationships to disease stage, capturing the patient experience across LGMD disease trajectory. + This study contributes to the limited evidence describing the patient experience of living with LGMD. The conceptual model can inform patient-centered assessment in future LGMD clinical trials. + © 2023. The Author(s). + + + + Johnston + Kelly + K + + Labcorp Drug Development, Gaithersburg, MD, USA. kelly.johnston@labcorp.com. + + + + Casstevens + Cristina + C + + Labcorp Drug Development, Gaithersburg, MD, USA. + + + + Patel + Vanessa Perez + VP + + Labcorp Drug Development, Gaithersburg, MD, USA. + + + + Merikle + Elizabeth + E + + Labcorp Drug Development, Gaithersburg, MD, USA. + + + + Presnall + Carrie + C + + Labcorp Drug Development, Gaithersburg, MD, USA. + + + + Audhya + Ivana + I + + Sarepta Therapeutics, Inc., Cambridge, MA, USA. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Adv Ther + 8611864 + 0741-238X + + + Burden + Caregiver + Concept elicitation + LGMD symptoms + Patient experience + Treatment expectations + +
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+ + + 36917435 + + 2023 + 03 + 14 + +
+ + 1179-2035 + + + 2023 + Mar + 14 + + + Sports medicine (Auckland, N.Z.) + Sports Med + + Effects of High-Intensity Interval Training Protocols on Blood Lactate Levels and Cognition in Healthy Adults: Systematic Review and Meta-Regression. + 10.1007/s40279-023-01815-2 + + Some health benefits from high-intensity interval training (HIIT) are facilitated by peripheral blood lactate levels. However, the lactate response from HIIT is variable and dependent on protocol parameters. + We aimed to determine the HIIT protocol parameters that elicited peak lactate levels, and how these levels are associated with post-HIIT cognitive performance. + We conducted a systematic review with meta-regression. + MEDLINE, Embase, CENTRAL, SPORTDiscus, and CINAHL + were searched from database inception to 8 April, 2022. Peer-reviewed primary research in healthy adults that determined lactate (mmol/L) and cognitive performance after one HIIT session was included. Mixed-effects meta-regressions determined the protocol parameters that elicited peak lactate levels, and linear regressions modelled the relationship between lactate levels and cognitive performance. + Study entries (n = 226) involving 2560 participants (mean age 24.1 ± 4.7 years) were included in the meta-regression. A low total work-interval volume (~ 5 min), recovery intervals that are about five times longer than work intervals, and a medium session volume (~ 15 min), elicited peak lactate levels, even when controlling for intensity, fitness (peak oxygen consumption) and blood measurement methods. Lactate levels immediately post-HIIT explained 14-17% of variance in Stroop interference condition at 30 min post-HIIT. + A HIIT protocol that uses the above parameters (e.g., 8 × 30-s maximal intensity with 90-s recovery) can elicit peak lactate, a molecule that is known to benefit the central nervous system and be involved in exercise training adaptations. This review reports the state of the science in regard to the lactate response following HIIT, which is relevant to those in the sports medicine field designing HIIT training programs. + Clinical Trial Registration: PROSPERO (CRD42020204400). + © 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG. + + + + Jacob + Nithin + N + + KITE Research Institute, Toronto Rehabilitation Institute-University Health Network, 550 University Ave, Toronto, ON, M5G 2A2, Canada. + + + Rehabilitation Sciences Institute, University of Toronto, Toronto, ON, Canada. + + + University Health Network, Toronto, ON, Canada. + + + + So + Isis + I + + KITE Research Institute, Toronto Rehabilitation Institute-University Health Network, 550 University Ave, Toronto, ON, M5G 2A2, Canada. + + + + Sharma + Bhanu + B + + Department of Medical Sciences, McMaster University, Hamilton, ON, Canada. + + + + Marzolini + Susan + S + + KITE Research Institute, Toronto Rehabilitation Institute-University Health Network, 550 University Ave, Toronto, ON, M5G 2A2, Canada. + + + University Health Network, Toronto, ON, Canada. + + + + Tartaglia + Maria Carmela + MC + + Institute of Medical Science, University of Toronto, Toronto, ON, Canada. + + + Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Kembril Research Institute, Toronto Western-University Health Network, Toronto, ON, Canada. + + + + Oh + Paul + P + + KITE Research Institute, Toronto Rehabilitation Institute-University Health Network, 550 University Ave, Toronto, ON, M5G 2A2, Canada. + + + University Health Network, Toronto, ON, Canada. + + + + Green + Robin + R + http://orcid.org/0000-0001-9451-3963 + + KITE Research Institute, Toronto Rehabilitation Institute-University Health Network, 550 University Ave, Toronto, ON, M5G 2A2, Canada. robin.green@uhn.ca. + + + Rehabilitation Sciences Institute, University of Toronto, Toronto, ON, Canada. robin.green@uhn.ca. + + + University Health Network, Toronto, ON, Canada. robin.green@uhn.ca. + + + + eng + + + UT458054 + Natural Sciences and Engineering Research Council of Canada + + + + + Systematic Review + + + 2023 + 03 + 14 + +
+ + New Zealand + Sports Med + 8412297 + 0112-1642 + + IM +
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+ + 1525-1497 + + + 2023 + Mar + 14 + + + Journal of general internal medicine + J Gen Intern Med + + Peer Support Helps Physicians Navigate Workplace Conflict. + 10.1007/s11606-023-08092-9 + + + Barghouth + Ursula + U + http://orcid.org/0000-0002-3829-4222 + + Physician Just Equity, Bodega Bay, CA, USA. ubarghouth@gmail.com. + + + + Gianakos + Arianna + A + + Physician Just Equity, Bodega Bay, CA, USA. + + + + Verran + Deborah + D + http://orcid.org/0000-0002-6134-3635 + + Physician Just Equity, Bodega Bay, CA, USA. + + + + Klein + Sandra E + SE + + Physician Just Equity, Bodega Bay, CA, USA. + + + + Butler + Karyn L + KL + + Physician Just Equity, Bodega Bay, CA, USA. + + + + Miller + Pringl + P + http://orcid.org/0000-0001-9659-9545 + + Physician Just Equity, Bodega Bay, CA, USA. + + + + eng + + Letter + + + 2023 + 03 + 14 + +
+ + United States + J Gen Intern Med + 8605834 + 0884-8734 + + IM +
+ + + + 2022 + 08 + 11 + + + 2023 + 02 + 08 + + + 2023 + 3 + 14 + 12 + 21 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917432 + 10.1007/s11606-023-08092-9 + 10.1007/s11606-023-08092-9 + + + + National Academies of Sciences, Engineering, and Medicine. Sexual Harassment of Women: Climate, Culture, and Consequences in Academic Sciences, Engineering, and Medicine. 2018. Washington, DC: The National Academies Press. https://doi.org/10.17226/24994 . + + + Hu Y-Y, Ellis RJ, Hewitt DB, et al. Discrimination, Abuse, Harassment, and Burnout in Surgical Residency Training. N Engl J Med. 2019;381(18):17411752. https://doi.org/10.1056/NEJMsa1903759 . + + + Joseph MM, Ahasic AM, Clark J, Templeton K. State of Women in Medicine: History, Challenges, and the Benefits of a Diverse Workforce. Pediatrics. 2021;148(Suppl 2):e2021051440C. https://doi.org/10.1542/peds.2021-051440C . + + + Balch Samora J, Van Heest A, Weber K, Ross W, Huff T, Carter C. Harassment, Discrimination, and Bullying in Orthopaedics: A Work Environment and Culture Survey. J Am Acad Orthop Surg. 2020;28(24):e1097-e1104. https://doi.org/10.5435/JAAOS-D-19-00822. + + + Pei KY, Cochran A. Workplace Bullying Among Surgeons-the Perfect Crime. Ann Surg. 2019;269(1):43-44. https://doi.org/10.1097/SLA.0000000000003018 . + + + Bates CK, Jagsi R, Gordon LK, et al. It Is Time for Zero Tolerance for Sexual Harassment in Academic Medicine. Acad Med. 2018;93(2):163-165. https://doi.org/10.1097/ACM.0000000000002050 . + + + +
+ + + 36917439 + + 2023 + 03 + 14 + +
+ + 1556-2891 + + + 2023 + Mar + 14 + + + Forensic science, medicine, and pathology + Forensic Sci Med Pathol + + Correction to: A forensic case of abdominal cocoon syndrome. + 10.1007/s12024-023-00604-7 + + + Tambuzzi + Stefano + S + http://orcid.org/0000-0003-4711-5545 + + Laboratorio di Istopatologia Forense e Microbiologia Medico Legale, Sezione di Medicina Legale e delle Assicurazioni, Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Via Luigi Mangiagalli 37, 20133, Milan, Italy. + + + + Gentile + Guendalina + G + http://orcid.org/0000-0002-4407-9844 + + Laboratorio di Istopatologia Forense e Microbiologia Medico Legale, Sezione di Medicina Legale e delle Assicurazioni, Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Via Luigi Mangiagalli 37, 20133, Milan, Italy. guendalina.gentile@unimi.it. + + + + Boracchi + Michele + M + http://orcid.org/0000-0002-4240-4121 + + Laboratorio di Istopatologia Forense e Microbiologia Medico Legale, Sezione di Medicina Legale e delle Assicurazioni, Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Via Luigi Mangiagalli 37, 20133, Milan, Italy. + + + + Zoja + Riccardo + R + http://orcid.org/0000-0003-3347-2541 + + Laboratorio di Istopatologia Forense e Microbiologia Medico Legale, Sezione di Medicina Legale e delle Assicurazioni, Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Via Luigi Mangiagalli 37, 20133, Milan, Italy. + + + + Gentilomo + Andrea + A + http://orcid.org/0000-0002-7762-2313 + + Dipartimento di Scienza Giuridiche "Cesare Beccaria", Università degli Studi di Milano, Via festa del Perdono, 7, 20122, Milan, Italy. + + + + eng + + Published Erratum + + + 2023 + 03 + 14 + +
+ + United States + Forensic Sci Med Pathol + 101236111 + 1547-769X + + IM + + + Forensic Sci Med Pathol. 2022 Dec 2;: + 36459388 + + +
+ + + + 2023 + 3 + 14 + 12 + 22 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917439 + 10.1007/s12024-023-00604-7 + 10.1007/s12024-023-00604-7 + + +
+ + + 36917418 + + 2023 + 03 + 14 + +
+ + 1573-3270 + + + 2023 + Mar + 14 + + + Applied psychophysiology and biofeedback + Appl Psychophysiol Biofeedback + + Methods for Heart Rate Variability Biofeedback (HRVB): A Systematic Review and Guidelines. + 10.1007/s10484-023-09582-6 + + Heart Rate Variability Biofeedback (HRVB) has been widely used to improve cardiovascular health and well-being. HRVB is based on breathing at an individual's resonance frequency, which stimulates respiratory sinus arrhythmia (RSA) and the baroreflex. There is, however, no methodological consensus on how to apply HRVB, while details about the protocol used are often not well reported. Thus, the objectives of this systematic review are to describe the different HRVB protocols and detect methodological concerns. PsycINFO, CINALH, Medline and Web of Science were searched between 2000 and April 2021. Data extraction and quality assessment were based on PRISMA guidelines. A total of 143 studies were finally included from any scientific field and any type of sample. Three protocols for HRVB were found: (i) "Optimal RF" (n = 37), each participant breathes at their previously detected RF; (ii) "Individual RF" (n = 48), each participant follows a biofeedback device that shows the optimal breathing rate based on cardiovascular data in real time, and (iii) "Preset-pace RF" (n = 51), all participants breathe at the same rate rate, usually 6 breaths/minute. In addition, we found several methodological differences for applying HRVB in terms of number of weeks, duration of breathing or combination of laboratory and home sessions. Remarkably, almost 2/3 of the studies did not report enough information to replicate the HRVB protocol in terms of breathing duration, inhalation/exhalation ratio, breathing control or body position. Methodological guidelines and a checklist are proposed to enhance the methodological quality of future HRVB studies and increase the information reported. + © 2023. The Author(s). + + + + Lalanza + Jaume F + JF + + Department of Basic Psychology, Universitat Autònoma de Barcelona, Bellaterra, Spain. + + + Department of Psychology, UiT The Arctic University of Norway, Tromsø, Norway. + + + + Lorente + Sonia + S + + Department of Psychobiology and Methodology of Health Science, Universitat Autònoma de Barcelona, Bellaterra, Spain. + + + Pediatric Area, Hospital de Terrassa, Consorci Sanitari de Terrassa, Terrassa, Spain. + + + + Bullich + Raimon + R + + Department of Basic Psychology, Universitat Autònoma de Barcelona, Bellaterra, Spain. + + + + García + Carlos + C + + Department of Basic Psychology, Universitat Autònoma de Barcelona, Bellaterra, Spain. + + + + Losilla + Josep-Maria + JM + + Department of Psychobiology and Methodology of Health Science, Universitat Autònoma de Barcelona, Bellaterra, Spain. + + + Sport Research Institute UAB, Universitat Autònoma de Barcelona, Bellaterra, Spain. + + + + Capdevila + Lluis + L + + Department of Basic Psychology, Universitat Autònoma de Barcelona, Bellaterra, Spain. lluis.capdevila@uab.cat. + + + Sport Research Institute UAB, Universitat Autònoma de Barcelona, Bellaterra, Spain. lluis.capdevila@uab.cat. + + + Departament of Basic Psychology, Universitat Autònoma de Barcelona, 08193, Bellaterra, Barcelona, Spain. lluis.capdevila@uab.cat. + + + + eng + + + PGC2018-100675-B-I00 + "Ministerio de Ciencia e Innovación" of the Spanish Government + + + + PID2019-107473RB-C21 + "Ministerio de Ciencia e Innovación" of the Spanish Government + + + + 2021SGR-00806 + Catalonian Government + + + + 2021SGR-00806 + Catalonian Government + + + + + Journal Article + Review + + + 2023 + 03 + 14 + +
+ + Germany + Appl Psychophysiol Biofeedback + 9712383 + 1090-0586 + + IM + + Checklist + Deep breathing + Guidelines + Heart Rate Variability Biofeedback + RSA + Resonance frequency + +
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+ + + 36917429 + + 2023 + 03 + 14 + +
+ + 1865-8652 + + + 2023 + Mar + 14 + + + Advances in therapy + Adv Ther + + Efficacy, Safety, Patient Experience, and Tolerability of Risankizumab Administered by On-Body Injector for Moderate to Severe Crohn's Disease. + 10.1007/s12325-023-02477-2 + + In patients with moderate to severe Crohn's disease (CD), intravenous induction and subcutaneous maintenance dosing with risankizumab was efficacious and well tolerated. Long-term management of CD via self-administration of risankizumab using an on-body injector (OBI) may improve treatment adherence through convenience and ease of use. + Within the FORTIFY maintenance study, 46 patients from the United States (US) sites participated in an open-label extension Substudy and received 180 mg or 360 mg risankizumab delivered subcutaneously via OBI [360 mg (2.4 mL, 150 mg/mL) or 180 mg (1.2 mL, 150 mg/mL)]. At the Week 0 visit, patients were trained (pre-injection) by site staff, using Instructions for Use (IFU) and a training video, to self-administer risankizumab at Weeks 0 (on site), 8 (at home), and 16 (on site). Key objectives of the Substudy 4 were to assess OBI usability (observer rating of successful self-administration), hazard-free self-injection at Weeks 0 and 16, and patient rating of acceptability using the Self-Injection Assessment Questionnaire (SIAQ) at Weeks 0, 8, and 16. Additionally, the proportion of patients in clinical remission (CD Activity Index < 150) was collected at Weeks 0 and 16. + All patients successfully self-administered risankizumab via OBI, including two patients who successfully self-administered with a second OBI (i.e., required two injection attempts). Acceptability of self-injection was high. Two patients (n = 2) experienced a use-related hazard. Stable clinical remission was observed with both risankizumab doses. Two patients experienced injection site reactions; neither was related to the OBI per investigator's assessment. Two device-related adverse events related to topical adhesive reactions were reported, both mild and resolved. No new safety risks were observed. + The efficacy and safety of maintenance risankizumab delivered via OBI and OBI usability support the use of this device in patients with moderate to severe CD. + ClinicalTrials.gov identifiers NCT03105102 (FORTIFY). + © 2023. The Author(s). + + + + Loftus + Edward V + EV + Jr + + Mayo Clinic College of Medicine and Science, Rochester, MN, USA. loftus.edward@mayo.edu. + + + + Griffith + Jenny + J + + AbbVie Inc, North Chicago, IL, USA. + + + + Neimark + Ezequiel + E + + AbbVie Inc, North Chicago, IL, USA. + + + + Song + Alexandra + A + + AbbVie Inc, North Chicago, IL, USA. + + + + Wallace + Kori + K + + AbbVie Inc, North Chicago, IL, USA. + + + + Nannapaneni + Sujani + S + + AbbVie Inc, North Chicago, IL, USA. + + + + Zhou + Ji + J + + AbbVie Inc, North Chicago, IL, USA. + + + + Byrne + Rachel + R + + AbbVie Inc, North Chicago, IL, USA. + + + + Kligys + Kristina + K + + AbbVie Inc, North Chicago, IL, USA. + + + + Pang + Yinuo + Y + + AbbVie Inc, North Chicago, IL, USA. + + + + Liao + Xiaomei + X + + AbbVie Inc, North Chicago, IL, USA. + + + + Kalabic + Jasmina + J + + AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany. + + + + Dubinsky + Marla + M + + Icahn School of Medicine at Mount Sinai, New York, NY, USA. + + + + eng + + + ClinicalTrials.gov + + NCT03105102 + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Adv Ther + 8611864 + 0741-238X + + + Crohn’s disease + Maintenance + On-body injector + Risankizumab + +
+ + + + 2023 + 01 + 23 + + + 2023 + 02 + 20 + + + 2023 + 3 + 14 + 12 + 21 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917429 + 10.1007/s12325-023-02477-2 + 10.1007/s12325-023-02477-2 + + + + Osterberg L, Blaschke T. Adherence to medication. N Engl J Med. 2005;353(5):487–97. + + 10.1056/NEJMra050100 + 16079372 + + + + Kane S, Huo D, Aikens J, Hanauer S. Medication nonadherence and the outcomes of patients with quiescent ulcerative colitis. Am J Med. 2003;114(1):39–43. + + 10.1016/S0002-9343(02)01383-9 + 12543288 + + + + Khan N, Abbas AM, Bazzano LA, Koleva YN, Krousel-Wood M. Long-term oral mesalazine adherence and the risk of disease flare in ulcerative colitis: nationwide 10-year retrospective cohort from the veterans affairs healthcare system. Aliment Pharmacol Ther. 2012;36(8):755–64. + + 10.1111/apt.12013 + 22882428 + + + + van der Have M, Oldenburg B, Kaptein AA, Jansen JM, Scheffer RCH, van Tuyl BA, et al. Non-adherence to anti-TNF therapy is associated with illness perceptions and clinical outcomes in outpatients with inflammatory bowel disease: results from a prospective multicentre study. ECCOJC. 2016;10(5):549–55. + + 10.1093/ecco-jcc/jjw002 + + + + Kane S, Shaya F. Medication non-adherence is associated with increased medical health care costs. Dig Dis Sci. 2008;53(4):1020–4. + + 10.1007/s10620-007-9968-0 + 17934828 + + + + Hommel KA, Davis CM, Baldassano RN. Medication adherence and quality of life in pediatric inflammatory bowel disease. J Pediatr Psychol. 2008;33(8):867–74. + + 10.1093/jpepsy/jsn022 + 18337262 + 2493513 + + + + Perry J, Chen A, Kariyawasam V, Collins G, Choong C, Teh WL, et al. Medication non-adherence in inflammatory bowel diseases is associated with disability. Intest Res. 2018;16(4):571–8. + + 10.5217/ir.2018.00033 + 30301333 + 6223449 + + + + Chan W, Chen A, Tiao D, Selinger C, Leong R. Medication adherence in inflammatory bowel disease. Intest Res. 2017;15(4):434. + + 10.5217/ir.2017.15.4.434 + 29142511 + 5683974 + + + + D’Haens G, Panaccione R, Baert F, Bossuyt P, Colombel JF, Danese S, et al. Risankizumab as induction therapy for Crohn’s disease: results from the phase 3 ADVANCE and MOTIVATE induction trials. Lancet. 2022;399(10340):2015–30. + + 10.1016/S0140-6736(22)00467-6 + 35644154 + + + + Ferrante M, Panaccione R, Baert F, Bossuyt P, Colombel JF, Danese S, et al. Risankizumab as maintenance therapy for moderately to severely active Crohn’s disease: results from the multicentre, randomised, double-blind, placebo-controlled, withdrawal phase 3 FORTIFY maintenance trial. Lancet. 2022;399(10340):2031–46. + + 10.1016/S0140-6736(22)00466-4 + 35644155 + + + + Keininger D, Coteur G. Assessment of self-injection experience in patients with rheumatoid arthritis: psychometric validation of the Self-Injection Assessment Questionnaire (SIAQ). Health Qual Life Outcomes. 2011;9(1):2. + + 10.1186/1477-7525-9-2 + 21232106 + 3027089 + + + + Suleiman AA, Goebel A, Bhatnagar S, D’Cunha R, Liu W, Pang Y. Population pharmacokinetic and exposure–response analyses for efficacy and safety of risankizumab in patients with active Crohn’s disease. Clin Pharm Ther. 2023:cpt.2831. + + + Blauvelt A, Leonardi CL, Gooderham M, Papp KA, Philipp S, Wu JJ, et al. Efficacy and safety of continuous risankizumab therapy vs treatment withdrawal in patients with moderate to severe plaque psoriasis: a phase 3 randomized clinical trial. JAMA Dermatol. 2020;156(6):649. + + 10.1001/jamadermatol.2020.0723 + 32267471 + + + + +
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+ + Sweden + Ambio + 0364220 + 0044-7447 + + IM +
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Environmental Health Perspectives 113: 286–291. + + + Gribble, M.O., R. Karimi, B.J. Feingold, J.F. Nyland, T.M. O’Hara, M.I. Gladyshev, and C.Y. Chen. 2016. Mercury, selenium and fish oils in marine food webs and implications for public health. Journal of the Marine Biological Association of the United Kingdom 96: 43–59. + + 10.1017/S0025315415001356 + + + + Groth, E. 2010. Ranking the contributions of commercial fish and shellfish varieties to mercury exposure in the United States: implications for risk communication. Environmental Research 110: 226–236. + + 10.1016/j.envres.2009.12.006 + + + + Groth, E. 2017. Scientific foundations of fish-consumption advice for pregnant women: epidemiological evidence, benefit-risk modeling, and an integrated approach. Environmental Research 152: 386–406. + + 10.1016/j.envres.2016.07.022 + + + + Hsu-Kim, H., C.S. Eckley, D. Achá, X. Feng, C.C. Gilmour, S. Jonsson, and C.P.J. Mitchell. 2018. 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+ + + 36917430 + + 2023 + 03 + 14 + +
+ + 1865-8652 + + + 2023 + Mar + 14 + + + Advances in therapy + Adv Ther + + Real-World Effectiveness and Safety of Two-Drug Single Pill Combinations of Antihypertensive Medications for Blood Pressure Management: A Follow-Up on Daily Cardiology Practice in Douala, Cameroon. + 10.1007/s12325-023-02461-w + + Hypertension is the leading cause of morbidity and mortality in sub-Saharan Africa (SSA). Current guidelines recommend using two or more antihypertensive agents in single pill combinations (SPCs) to treat hypertension, but data from African patients that support these recommendations are lacking. We assessed the effectiveness and tolerance of three SPCs in lowering blood pressure (BP) amongst hypertensive patients in Douala. + All patients included in the hypertension registry of the Douala General Hospital and the Douala Cardiovascular Center between January 2010 and May 2020, and receiving a two-drug SPCs (renin-angiotensin system inhibitors (RAASi) + diuretics (DIU), calcium channel blockers (CCB) + RAASi, or DIU + CCB) were tracked from baseline through 16 weeks. Our primary outcome was a decrease in systolic BP (SBP) from baseline up to 16 weeks after initiation of treatment. A mixed linear repeated model was used to evaluate the change of SBP from baseline to week 16, while controlling for age, gender, and baseline SBP. Statistical significance was set at p < 0.05. + Of 377 participants on two-drug SPCs, 123 were on CCB + DIU, 96 on RAASi + CCB, and 158 on RAASi + DIU. The mean age was 54.6 (± 11.2) years. At baseline, participants on RAASi + CCB presented with slightly higher SBP compared to the other two groups. Overall, the SBP decreased by 34.3 (± 14.2) mmHg from baseline values and this was comparable across the three groups of SPCs (p = 0.118). The control rate after 16 weeks of follow-up was 62.3% with no significant difference between groups. The occurrence of adverse events was 3.4% and was comparable among the three groups. + The three two-drug SPCs were highly effective in reducing and controlling BP with low and similar rates of adverse effects. Long-term data documenting safety and whether these agents exert a differential cardiovascular effect in addition to and independent of their BP-lowering effect are needed for SSA populations. + © 2023. The Author(s). + + + + Dzudie + Anastase + A + http://orcid.org/0000-0003-4038-4128 + + Service of Internal Medicine and Cardiology, Department of Internal Medicine and Subspecialties, Douala General Hospital, 4856, Douala, Cameroon. aitdzudie@yahoo.com. + + + Lown Scholar Programs, Cardiovascular Health, Harvard T H Chan School of Public Health, Boston, USA. aitdzudie@yahoo.com. + + + Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon. aitdzudie@yahoo.com. + + + + Barche + Blaise + B + + Clinical Research Education Networking & Consultancy (CRENC), Douala, Cameroon. + + + + Zomene + Franck + F + + Clinical Research Education Networking & Consultancy (CRENC), Douala, Cameroon. + + + + Ebasone + Peter Vanes + PV + + Clinical Research Education Networking & Consultancy (CRENC), Douala, Cameroon. + + + + Nkoke + Clovis + C + + Faculty of Health Sciences, University of Buea, Buea, Cameroon. + + + + Mouliom + Sidick + S + + Service of Internal Medicine and Cardiology, Department of Internal Medicine and Subspecialties, Douala General Hospital, 4856, Douala, Cameroon. + + + Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon. + + + + Sidikatou + Djibrilla + D + + Faculty of Health Sciences, University of Buea, Buea, Cameroon. + + + + Lade + Viche + V + + Service of Internal Medicine and Cardiology, Department of Internal Medicine and Subspecialties, Douala General Hospital, 4856, Douala, Cameroon. + + + + Ngote + Henri + H + + Service of Internal Medicine and Cardiology, Department of Internal Medicine and Subspecialties, Douala General Hospital, 4856, Douala, Cameroon. + + + + Njankouo + Yacouba Mapoure + YM + + Service of Internal Medicine and Cardiology, Department of Internal Medicine and Subspecialties, Douala General Hospital, 4856, Douala, Cameroon. + + + Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon. + + + + Mbatchou + Bertrand Hugo + BH + + Service of Internal Medicine and Cardiology, Department of Internal Medicine and Subspecialties, Douala General Hospital, 4856, Douala, Cameroon. + + + Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon. + + + + Kamdem + Felicite + F + + Service of Internal Medicine and Cardiology, Department of Internal Medicine and Subspecialties, Douala General Hospital, 4856, Douala, Cameroon. + + + Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon. + + + + Njebet + Jules + J + + Douala Cardiovascular Center, Douala, Cameroon. + + + + Kengne + Andre Pascal + AP + + Non-Communicable Diseases Research Unit, South African Medical Research Council, Francie Van Zijl Drive Parowvallei, Tygerberg, PO Box 19070, Cape Town, 7505, South Africa. + + + + Choukem + Simeon Pierre + SP + + Service of Internal Medicine and Cardiology, Department of Internal Medicine and Subspecialties, Douala General Hospital, 4856, Douala, Cameroon. + + + Department of Internal Medicine and Specialties, Faculty of Medicine and Pharmaceutical Sciences, University of Dschang, Dschang, Cameroon. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Adv Ther + 8611864 + 0741-238X + + + Calcium channel blocker + Diuretic + Effectiveness + Hypertension + Real-world data + Renin–angiotensin system inhibitors + Single pill combination + +
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+ + + 36917440 + + 2023 + 03 + 14 + +
+ + 1878-7479 + + + 2023 + Mar + 14 + + + Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics + Neurotherapeutics + + Pulsed Focused Ultrasound Reduces Hippocampal Volume Loss and Improves Behavioral Performance in the Kainic Acid Rat Model of Epilepsy. + 10.1007/s13311-023-01363-7 + + Focused ultrasound (FUS) has the potential to modulate regional brain excitability and possibly aid seizure control; however, effects on behavior of FUS used as a seizure therapy are unknown. This study explores behavioral effects and hippocampal restoration induced by pulsed FUS in a kainic acid (KA) animal model of temporal lobe epilepsy. Twenty-nine male Sprague-Dawley rats were observed for 20 weeks with anatomical magnetic resonance imaging (MRI) and behavioral performance evaluations, comprising measures of anxiety, limb usage, sociability, and memory. FUS targeted to the right hippocampus was given 9 and 14 weeks after KA was delivered to the right amygdala. Ultrasound pulsations were delivered with the acoustic settings of 0.25 of mechanical index, 0.5 W/cm2 of intensity spatial peak temporal average (ISPTA), 100 Hz of pulse repetition frequency, and 30% of duty cycle, during three consecutive pulse trains of 10 min separated by 5-min rests. Controls included normal animals with sham injections and KA-exposed animals without FUS exposure. Longitudinal MRI observations showed that FUS substantially protected hippocampal and striatal structures from KA-induced atrophy. KA alone increased anxiety, impaired contralateral limb usage, and reduced sociability and learning. Two courses of FUS sonications partially ameliorated these impairments by enhancing exploring and learning, balancing limb usage, and increasing social interaction. The histology results indicated that two sonications enhanced neuroprotection effect and decreased the inflammation markers induced by KA. This study supports existence of both neuroprotective and beneficial behavioral effects from low-intensity pulsed ultrasound in the KA animal model of epilepsy. + © 2023. The Author(s). + + + + Chu + Po-Chun + PC + + Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan. + + + + Huang + Chen-Syuan + CS + + Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan. + + + + Ing + Shan-Zhi + SZ + + School of Veterinary Medicine, National Taiwan University, Taipei, Taiwan. + + + + Yu + Hsiang-Yu + HY + + Department of Neurology, Taipei Veteran General Hospital, Taipei, Taiwan. + + + School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan. + + + + Fisher + Robert S + RS + + Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Palo Alto, CA, USA. + + + + Liu + Hao-Li + HL + http://orcid.org/0000-0003-3512-7215 + + Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan. hlliu@ntu.edu.tw. + + + + eng + + + 108-2221-E-002-175-MY3 + Ministry of Science and Technology + + + + 110-2321-B-002-014- + Ministry of Science and Technology + + + + 111-2321-B-002-014- + Ministry of Science and Technology + + + + 111-2221-E-002-032-MY3 + Ministry of Science and Technology + + + + 111HT911014 + NaviFUS Corporation + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Neurotherapeutics + 101290381 + 1878-7479 + + IM + + Focused ultrasound + Kainic acid model + Neuromodulation + Temporal lobe epilepsy + +
+ + + + 2023 + 02 + 25 + + + 2023 + 3 + 14 + 12 + 22 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917440 + 10.1007/s13311-023-01363-7 + 10.1007/s13311-023-01363-7 + + + + Fiest KM, Sauro KM, Wiebe S, Patten SB, Kwon CS, Dykeman J, et al. Prevalence and incidence of epilepsy: a systematic review and meta-analysis of international studies. Neurology. 2017;88(3):296–303. + + 27986877 + 5272794 + 10.1212/WNL.0000000000003509 + + + + Fisher RS, van Emde BW, Blume W, Elger C, Genton P, Lee P, et al. Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia. 2005;46(4):470–2. + + 15816939 + 10.1111/j.0013-9580.2005.66104.x + + + + Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, et al. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia. 2017;58(4):522–30. + + 28276060 + 10.1111/epi.13670 + + + + Falconer MA, Serafetinides EA, Corsellis JA. Etiology and pathogenesis of temporal lobe epilepsy. Arch Neurol. 1964;10:233–48. + + 14106980 + 10.1001/archneur.1964.00460150003001 + + + + Engel J Jr. Introduction to temporal lobe epilepsy. Epilepsy Res. 1996;26(1):141–50. + + 8985696 + 10.1016/S0920-1211(96)00043-5 + + + + Levesque M, Avoli M. The kainic acid model of temporal lobe epilepsy. Neurosci Biobehav Rev. 2013;37(10 Pt 2):2887–99. + + 24184743 + 4878897 + 10.1016/j.neubiorev.2013.10.011 + + + + Ben-Ari Y, Lagowska Y, Le Gal La Salle G, Tremblay E, Ottersen OP, Naquet R. Diazepam pretreatment reduces distant hippocampal damage induced by intra-amygdaloid injections of kainic acid. 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Brain Stimul. 2011;4(3):125–36. + + 21777872 + 10.1016/j.brs.2011.03.007 + + + + Hakimova H, Kim S, Chu K, Lee SK, Jeong B, Jeon D. Ultrasound stimulation inhibits recurrent seizures and improves behavioral outcome in an experimental model of mesial temporal lobe epilepsy. Epilepsy Behav. 2015;49:26–32. + + 25940106 + 10.1016/j.yebeh.2015.04.008 + + + + Chen SG, Tsai CH, Lin CJ, Lee CC, Yu HY, Hsieh TH, et al. Transcranial focused ultrasound pulsation suppresses pentylenetetrazol induced epilepsy in vivo. Brain Stimul. 2020;13(1):35–46. + + 31575487 + 10.1016/j.brs.2019.09.011 + + + + Zou J, Yi S, Niu L, Zhou H, Lin Z, Lin Z, et al. Neuroprotective effect of ultrasound neuromodulation on kainic acid-induced epilepsy in mice. IEEE Trans Ultrason Ferroelectr Freq Control. 2021;68:3006–16. + + 33979280 + 10.1109/TUFFC.2021.3079628 + + + + Lin Z, Meng L, Zou J, Zhou W, Huang X, Xue S, et al. Non-invasive ultrasonic neuromodulation of neuronal excitability for treatment of epilepsy. 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+ + + 36917443 + + 2023 + 03 + 14 + +
+ + 1522-1709 + + + 2023 + Mar + 14 + + + Sleep & breathing = Schlaf & Atmung + Sleep Breath + + Use of historical remote monitoring data to determine predictors of CPAP non-compliance in patients with OSA. + 10.1007/s11325-023-02806-3 + + Continuous positive airway pressure (CPAP) is the gold standard treatment for obstructive sleep apnoea. This study aimed to use complete usage data collected remotely from modern CPAP devices to identify compliance trends and clinical predictors of CPAP usage. + Group usage data were analysed for a large cohort at a single tertiary sleep-centre before a detailed review of a 90-day reporting window for each patient was conducted. Individual data were collected for a smaller cohort of patients including demographics, past medical history and diagnostic sleep study results. A zero-inflated negative binomial regression model was used to determine associations between patient characteristics and usage days. + Of 6450 patients who were prescribed CPAP and included in the initial service analysis, 476 patients were included in the sub-group. Complete usage data revealed that 46% of patients were fully compliant with CPAP therapy. Compliance fell from 55 to 46% by day 90 and remained at this rate going forward. Significant predictors of CPAP non-compliance included being in the lowest quartile of Index of Multiple Deprivation scores (most deprived) compared with the highest quartile (least deprived) (p = .005), and less severe oxygen desaturation index (ODI) on diagnosis (p = .03). + Complete usage data show that compliance at day 90 appears to be a good indicator of future CPAP usage. Predictors of CPAP non-compliance may include lower socioeconomic status, and lower ODI. + © 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG. + + + + Cowen + Jake + J + + Department of Respiratory Medicine, Aintree University Hospital, Liverpool University Hospitals NHS Foundation Trust, Liverpool, L9 7AL, UK. jakecowen@doctors.org.uk. + + + + Harrison + Stephanie + S + + Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, UK. + + + Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK. + + + + Thom + Lydia + L + + Department of Respiratory Medicine, Aintree University Hospital, Liverpool University Hospitals NHS Foundation Trust, Liverpool, L9 7AL, UK. + + + + Thomas + Matt + M + + Department of Respiratory Medicine, Aintree University Hospital, Liverpool University Hospitals NHS Foundation Trust, Liverpool, L9 7AL, UK. + + + + Sedano + Joanna + J + + Department of Respiratory Medicine, Aintree University Hospital, Liverpool University Hospitals NHS Foundation Trust, Liverpool, L9 7AL, UK. + + + + Stephens + Phil + P + + Resmed UK, Quad 1, First Floor, Becquerel Ave, Harwell Campus, Didcot, UK. + + + + Lip + Gregory Y H + GYH + + Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, UK. + + + Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK. + + + Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark. + + + + Craig + Sonya + S + + Department of Respiratory Medicine, Aintree University Hospital, Liverpool University Hospitals NHS Foundation Trust, Liverpool, L9 7AL, UK. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Sleep Breath + 9804161 + 1520-9512 + + IM + + CPAP + Obstructive sleep apnoea + Phenotyping + Sleep disordered breathing + Sleep medicine + Virtual data + +
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+ + + 36917438 + + 2023 + 03 + 14 + +
+ + 1873-9601 + + + 2023 + Mar + 14 + + + Journal of cell communication and signaling + J Cell Commun Signal + + mir-98-5p regulates gluconeogenesis and lipogenesis by targeting PPP1R15B in hepatocytes. + 10.1007/s12079-023-00735-0 + + Several reports suggest that circulatory miRNAs are deregulated in diverse diseases and used as markers for disease diagnosis and prognosis. Here we show that miR-98-5p, that is down-regulated in the circulation during diabetes, regulates hepatic gluconeogenesis and lipogenesis by targeting PPP1R15B. miR-98-5p overexpression significantly decreased the transcript and protein levels of PPP1R15B in hepatic HepG2 cells and increased p-eIF2α expression and these were prevented in the presence of its inhibitor. Two major hepatic hallmarks during diabetes i.e. hepatic lipid accumulation and glucose output were explored towards physiological relevance. As compared to scramble, overexpression of miR-98-5p decreased the transcript levels of both gluconeogenic and lipogenic genes together with a significant reduction in hepatic glucose production and fat accumulation in HepG2 cells. Using PASTAA to detect common transcription factors regulating these altered genes, CREB emerged as the most significantly enriched transcription factor. While miR-98-5p overexpression did not change the transcript levels of CREB, there was a significant change in its protein levels. While similar effects on gluconeogenic and lipogenic gene expression were detected using the PPP1R15B siRNA, the opposite was observed in the presence of miR-98-5p inhibitor alone. All these suggest that by targeting PPP1R15B, miR-98-5p regulates hepatic steatosis and glucose output; deregulation of which are characteristic hepatic features during diabetes. Therapeutic intervention of the miR-98/PPP1R15B axis might offer a potential strategy to target aberrant hepatic metabolism during diabetes. + © 2023. The Author(s). + + + + Khan + Rukshar + R + + CSIR-Institute of Genomics and Integrative Biology, Mall Road, Delhi, 110007, India. + + + Jamia Millia Islamia, Jamia Nagar, Okhla, Delhi, New Delhi, 110025, India. + + + + Verma + Amit Kumar + AK + + Jamia Millia Islamia, Jamia Nagar, Okhla, Delhi, New Delhi, 110025, India. + + + + Datta + Malabika + M + http://orcid.org/0000-0002-2559-9991 + + CSIR-Institute of Genomics and Integrative Biology, Mall Road, Delhi, 110007, India. mdatta@igib.res.in. + + + Academy of Scientific and Innovative Research, CSIR-HRDC, Kamala Nehru Nagar, Ghaziabad, Uttar Pradesh, 201002, India. mdatta@igib.res.in. + + + + eng + + + csir + csir + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + Netherlands + J Cell Commun Signal + 101308338 + 1873-9601 + + + CREB + Circulation + Diabetes + Gluconeogenesis + Hepatic glucose output + Liver + NAFLD + PPP1R15B + Steatosis + miRNA + p-eiF2α + +
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+ + + 36917437 + + 2023 + 03 + 14 + +
+ + 1559-0291 + + + 2023 + Mar + 14 + + + Applied biochemistry and biotechnology + Appl Biochem Biotechnol + + The Correlation Between IFNG Gene Methylation and Th1|Th2 Cell Balance in ROU and the Interventional Study of Jiaweidaochi Powder. + 10.1007/s12010-023-04417-w + + The pathogenesis of recurrent oral ulcers (ROU) is complex, with a long duration of illness and challenging to cure. According to traditional Chinese medicine (TCM),"heat accumulation in the heart-spleen" is one of the main causative factors. Jiaweidaochi powder (JWDCP) is based on the ancient Chinese medicine formula JWDCS, with the addition of Tongcao and gypsum and the removal of Mu Tong. It is generally used to treat "heat accumulation in the heart-spleen." Previous studies have demonstrated that it effectively reduces recurrence rates and is anti-inflammatory in modulating immunity. The ROU rats' model for JWDCP intervention treatment had been established, and histological tests revealed that JWDCP has a therapeutic effect on the pathological changes in the oral mucosa. In addition, the methylation levels of peripheral blood IFNG gene were detected by bisulfite sequencing PCR (BSP), and the methylation levels of the IFNG promoter region in the model group and each dose group were lower than those in the control group. However, no significant methylation differences were observed. Furthermore, the results of enzyme-linked immunosorbent assay (ELISA) and RNA quantitative polymerase chain reaction showed that JWDCP could reduce IFN-γ and IL-4 protein concentrations, with high GATA-3 mRNA production, T-bet mRNAproduction was upgraded, elevated IL-4 mRNA levels, and reduced IFN-γ mRNA levels after treatment (P < 0.001). The expression of transcription factor T-betmRNA and GATA-3 gene mRNA was accompanied by changes in IFN-γmRNA and IL-4mRNA, demonstrating that Th2 type differentiation in RAS suppresses the body's immunity and that the imbalance of transcription factor expression further leads to Th1/Th2 drift. JWDCP is likely to reduce the protein concentration by regulating the imbalance of transcription factors and enhancing antioxidant capacity, thus achieving therapeutic effects. Treatment of recurrent oral ulcer models is not sufficient to reset IFNG methylation levels, correlating with the refractoriness of ROU, further confirming the complexity of epigenetic mechanisms and that epigenetic alterations in specific mediators may persist locally. + © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. + + + + Hu + Yue + Y + + Department of Graduate School, Shanxi University of Chinese Medicine, Taiyuan, 030619, China. + + + + Guo + Hongbo + H + http://orcid.org/0000-0001-5260-4736 + + Department of Traditional Chinese Medicine, First Hospital of Shanxi Medical University, Taiyuan, 030001, China. HongboGuoChina@outlook.com. + + + + He + Lu + L + + Department of Traditional Chinese Medicine, Xingyi People's Hospital, Xingyi, 562400, China. + + + + Wang + Qianqian + Q + + Department of Graduate School, Shanxi Medical University, Taiyuan, 030001, China. + + + + Li + Yanqing + Y + + Department of Graduate School, Shanxi Medical University, Taiyuan, 030001, China. + + + + Weng + Jiankun + J + + Department of Graduate School, Shanxi University of Chinese Medicine, Taiyuan, 030619, China. + + + + Zhang + Rong + R + + Department of Graduate School, Shanxi Medical University, Taiyuan, 030001, China. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Appl Biochem Biotechnol + 8208561 + 0273-2289 + + IM + + IFNG + Jiaweidaochi powder + Recurrent oral ulcers + Th cells + +
+ + + + 2023 + 02 + 17 + + + 2023 + 3 + 14 + 12 + 22 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917437 + 10.1007/s12010-023-04417-w + 10.1007/s12010-023-04417-w + + + + Toche, P., Salinas, L., Guzmán, M. M., Afani, S., & Jadue, A. (2007). Recurrent oral ulcer: Clinical characteristic and differential diagnosis. Revista Chilena de Infectologia: Organo Oficial de la Sociedad Chilena de Infectologia, 24(3), 215–219. + + + Sánchez, J., Conejero, C., & Conejero, R. (2020). Recurrent aphthous stomatitis. Actas Dermo-Sifiliográficas (English Edition), 111(6), 471–480. + + 10.1016/j.adengl.2019.09.006 + + + + Altenburg, A., El-Haj, N., Micheli, C., Puttkammer, M., Abdel-Naser, M. B., & Zouboulis, C. C. (2014). The treatment of chronic recurrent oral aphthous ulcers. Deutsches Ärzteblatt International, 111(40), 665. + + 25346356 + 4215084 + + + + Queiroz, S. I. M. L., Silva, M. VAd., Medeiros, A. MCd., Oliveira, PTd., Gurgel, BCd. V., & Silveira, É. JDd. 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+ + + 36917446 + + 2023 + 03 + 14 + +
+ + 1463-9084 + + + 2023 + Mar + 14 + + + Physical chemistry chemical physics : PCCP + Phys Chem Chem Phys + + Effect of (H2O)n (n = 1 and 2) on HOCl + Cl reaction. + 10.1039/d2cp04044a + + In the present work, we investigate the effect of water molecules (H2O and (H2O)2) on HOCl + Cl˙ → ClO˙ + HCl (R1), and HOCl + Cl˙ → OH˙ + Cl2 (R2) reactions using quantum chemical and kinetics calculations. The present investigation suggests that a water molecule decreases the energy barrier of both reactions significantly, compared to uncatalyzed reaction. However, the effective rate constants for the water catalyzed path for both channels (R1 and R2) were found to be lower than the bimolecular rate constant of the uncatalyzed path. Further, it was found that the R2 reaction will dominate over the R1 reaction, with or without catalyst. Interestingly, the uncatalyzed title reaction was found to be two times faster than the HOCl + OH˙ reaction, but in the presence of water, HOCl + OH˙ becomes the dominant reaction compared to the HOCl + Cl˙ reaction in the atmosphere. In addition, the concentration of bimolecular complexes formed in the presence of a catalyst are found to be higher than the precursor molecule of the uncatalyzed reaction, which suggests that in the presence of catalyst, the HOCl + Cl˙ reaction would favor the catalyzed path rather than the uncatalyzed path. + + + + Kumar + Amit + A + + Department of Chemistry, Malaviya National Institute of Technology Jaipur, Jaipur, 302017, India. pradeep.chy@mnit.ac.in. + + + + Kumar + Pradeep + P + http://orcid.org/0000-0002-9870-6858 + + Department of Chemistry, Malaviya National Institute of Technology Jaipur, Jaipur, 302017, India. pradeep.chy@mnit.ac.in. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + England + Phys Chem Chem Phys + 100888160 + 1463-9076 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 22 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917446 + 10.1039/d2cp04044a + + +
+ + + 36917444 + + 2023 + 03 + 14 + +
+ + 1179-187X + + + 2023 + Mar + 14 + + + American journal of cardiovascular drugs : drugs, devices, and other interventions + Am J Cardiovasc Drugs + + Characteristics and Trends in Clinical Trials of Cardiovascular Drugs in China from 2009 to 2021. + 10.1007/s40256-023-00575-8 + + Cardiovascular disease remains the leading cause of death worldwide and brings a heavy burden. However, the development of cardiovascular drug clinical trials in China remains unclear. The purpose of this study was to identify the status of clinical trials of cardiovascular drugs in China and provide a reference for stakeholders' decisions. + Data were collected from the National Medical Products Administration (NMPA) Registration and Information Disclosure Platform for Drug Clinical Trials before July 1, 2021. We collected all information about clinical trials, including study design, and leading unit. The landscape of cardiovascular drug clinical trials was analyzed by the characteristics, time trends, indications, and geographical distribution. + A total of 1666 cardiovascular drug clinical trials were launched from 2009 to 2021 in China. Bioequivalence/bioavailability studies accounted for the most significant proportion (1099 [65.97%]), followed by phase I (296 [17.77%]), phase III (135 [8.10%]), phase II (118 [7.08%]), and phase IV trials (18 [1.08%]). Initiated trials increased by 23.45% annually from 2009 to 2020. Trials of hypertension accounted for the most significant number, followed by coronary heart disease, dyslipidemia, and heart failure. Most trials (66.68%) were conducted in eastern China, followed by the central and western regions, showing a regional disparity as leading units. + Despite the significant progress of cardiovascular drug clinical trials in China, there is still a long way to innovative drug research and development, requiring persistent policy support and more investment. Innovation, quality, efficiency, and equity need to be carefully considered by all stakeholders in clinical trials. + © 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG. + + + + Hao + Jun + J + + Medical Research and Biometrics Center, National Clinical Research Center for Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China. + + + + Li + Chen + C + + Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. + + + + Li + Junrong + J + + Fujian Provincial Center for Disease Control and Prevention, Fuzhou, China. + + + + Wang + Chuangshi + C + + Medical Research and Biometrics Center, National Clinical Research Center for Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China. + + + + Li + Yang + Y + + Medical Research and Biometrics Center, National Clinical Research Center for Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China. + + + + He + Chen + C + + Department of Cardiology, The Guangxi Zhuang Autonomous Region Workers' Hospital, Nanning, Guangxi, China. + + + + Liu + Weida + W + + Medical Research Center, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China. + + + + Li + Sidong + S + + Medical Research and Biometrics Center, National Clinical Research Center for Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China. + + + + Zuo + Ling + L + + Department of Integrated Care Management Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China. + + + + Hui + Wen + W + + Department of Science and Technology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. huiwen@wchscu.cn. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + New Zealand + Am J Cardiovasc Drugs + 100967755 + 1175-3277 + + IM +
+ + + + 2023 + 02 + 15 + + + 2023 + 3 + 14 + 12 + 22 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917444 + 10.1007/s40256-023-00575-8 + 10.1007/s40256-023-00575-8 + + + + The Writing Committee of the Report on Cardiovascular Health and Diseases in China. Report on Cardiovascular Health and Diseases in China 2021: an Updated Summary. Chin Circ J. 2022;37(6):553–78. + + + Fordyce CB, Roe MT, Ahmad T, et al. Cardiovascular drug development: is it dead or just hibernating? J Am Coll Cardiol. 2015;65(15):1567–82. + + 10.1016/j.jacc.2015.03.016 + 25881939 + + + + Sacks LV, Shamsuddin HH, Yasinskaya YI, Bouri K, Lanthier ML, Sherman RE. Scientific and regulatory reasons for delay and denial of FDA approval of initial applications for new drugs, 2000–2012. JAMA. 2014;311(4):378–84. + + 10.1001/jama.2013.282542 + 24449316 + + + + Kaitin KI, DiMasi JA. Pharmaceutical innovation in the 21st century: new drug approvals in the first decade, 2000–2009. 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N Engl J Med. 2020;383(15):1436–46. + + 10.1056/NEJMoa2024816 + 32970396 + + + + Packer M, Anker SD, Butler J, et al. Cardiovascular and renal outcomes with empagliflozin in heart failure. N Engl J Med. 2020;383(15):1413–24. + + 10.1056/NEJMoa2022190 + 32865377 + + + + Armstrong PW, Pieske B, Anstrom KJ, et al. Vericiguat in patients with heart failure and reduced ejection fraction. N Engl J Med. 2020;382(20):1883–93. + + 10.1056/NEJMoa1915928 + 32222134 + + + + Jackson AM, Jhund PS, Anand IS, et al. Sacubitril-valsartan as a treatment for apparent resistant hypertension in patients with heart failure and preserved ejection fraction. Eur Heart J. 2021;42(36):3741–52. + + 10.1093/eurheartj/ehab499 + 34392331 + 8455346 + + + + Hao P, Jiang F, Cheng J, Ma L, Zhang Y, Zhao Y. Traditional Chinese medicine for cardiovascular disease: evidence and potential mechanisms. J Am Coll Cardiol. 2017;69(24):2952–66. + + 10.1016/j.jacc.2017.04.041 + 28619197 + + + + Li X, Zhang J, Huang J, et al. A multicenter, randomized, double-blind, parallel-group, placebo-controlled study of the effects of qili qiangxin capsules in patients with chronic heart failure. J Am Coll Cardiol. 2013;62(12):1065–72. + + 10.1016/j.jacc.2013.05.035 + 23747768 + + + + Notice on printing and distributing the requirements for the work of the construction of the major clinical drug evaluation technology platform for major new drugs. 2019. http://www.nhc.gov.cn/qjjys/s3593k/201901/f4b2ff724a564b35964b296b427b9002.shtml . Accessed 2 Apr 2022 + + + +
+ + + 36917433 + + 2023 + 03 + 14 + +
+ + 1932-2267 + + + 2023 + Mar + 14 + + + Journal of cancer survivorship : research and practice + J Cancer Surviv + + Psychological and physical function in allogeneic hematopoietic cell transplant survivors with chronic graft-versus-host disease. + 10.1007/s11764-023-01354-9 + + Chronic graft-versus-host disease (cGVHD) is a common late complication of allogeneic hematopoietic cell transplantation (HCT). This study comprehensively evaluated physical and psychological function among individuals with cGVHD. Additional aims were to investigate relationships between disease severity and psychological and physical function, and to investigate patterns of psychological and physical function by disease site. + Adults at least 6 months post allogeneic HCT were enrolled and either had cGVHD (n =59) or served as a reference sample of HCT survivors with no cGVHD history (n = 19). Participants completed self-report measures of depression, anxiety, fatigue, insomnia, pain, cognition, and sexual function and had a comprehensive clinical evaluation of cGVHD using NIH consensus scoring criteria. Participants with cGVHD were stratified by disease severity and site and compared to the reference group with no cGVHD. + Participants with mild cGVHD had comparable psychological and physical symptoms to the reference sample, while participants with moderate cGVHD experienced more severe anxiety and problems with sexual function, and participants with severe cGVHD experienced more severe depressive symptoms and pain compared to the reference sample. Participants with cGVHD manifesting in the skin and GI tract had the most severe symptoms, including mood disturbance, fatigue, and pain. + Results suggest that patients with more severe cGVHD and those with cGVHD manifesting in the skin, GI tract, and lungs are at risk for poorer psychological and physical outcomes and may benefit from proactive interventions to optimize function. + © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. + + + + Hansen + Jenna L + JL + + Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, 6001 Research Park Blvd, Milwaukee, WI, 53719, USA. + + + + Juckett + Mark B + MB + + Masonic Cancer Center, University of Minnesota, 420 Delaware Street SE Minneapolis, Minneapolis, MN, 55455, USA. + + + + Foster + Mikayla A + MA + + Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, 6001 Research Park Blvd, Milwaukee, WI, 53719, USA. + + + + Rumble + Meredith E + ME + + Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, 6001 Research Park Blvd, Milwaukee, WI, 53719, USA. + + + Center for Sleep Medicine and Research, University of Wisconsin-Madison, Madison, WI, USA. + + + + Morris + Keayra E + KE + + Department of Psychiatry, Medical College of Wisconsin, 900 N 92nd St, Milwaukee, WI, 53226, USA. + + + + Hematti + Peiman + P + + Division of Hematology, Medical Oncology, and Palliative Medicine, Department of Medicine, School of Medicine and Public Health, University of Wisconsin, 1685 Highland Avenue, Madison, WI, 53705, USA. + + + University of Wisconsin Carbone Cancer Center, 1111 Highland Ave, Madison, WI, 53705, USA. + + + + Costanzo + Erin S + ES + + Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, 6001 Research Park Blvd, Milwaukee, WI, 53719, USA. ecostanzo@wisc.edu. + + + University of Wisconsin Carbone Cancer Center, 1111 Highland Ave, Madison, WI, 53705, USA. ecostanzo@wisc.edu. + + + + eng + + + Hilldale Award + University of Wisconsin-Madison + + + + Hilldale Award + University of Wisconsin-Madison + + + + P30 CA014520 + CA + NCI NIH HHS + United States + + + P30 CA014520 + CA + NCI NIH HHS + United States + + + P30 CA014520 + CA + NCI NIH HHS + United States + + + K07 CA 136966 + National Cancer Institute, National Institutes of Health, United States + + + + UL1 TR002373 + TR + NCATS NIH HHS + United States + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + J Cancer Surviv + 101307557 + 1932-2259 + + IM + + Anxiety + Chronic graft-versus-host disease + Depression + Hematopoietic cell transplant + Pain + Sexual function + +
+ + + + 2022 + 11 + 30 + + + 2023 + 02 + 26 + + + 2023 + 3 + 14 + 12 + 22 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917433 + 10.1007/s11764-023-01354-9 + 10.1007/s11764-023-01354-9 + + + + Cooke KR, Luznik L, Sarantopoulos S, Hakim FT, Jagasia M, Fowler DH, et al. The Biology of Chronic Graft-versus-Host Disease: A Task Force Report from the National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease. Biol Blood Marrow Transplant. 2017;23(2):211–34. + + 10.1016/j.bbmt.2016.09.023 + 27713092 + + + + Atilla E, Atilla PA, Toprak SK, Demirer T. A review of late complications of allogeneic hematopoietic stem cell transplantations. Clin Transplant. 2017; 31(10). + + + Arai S, Arora M, Wang T, Spellman SR, He W, Couriel DR, et al. Increasing incidence of chronic graft-versus-host disease in allogeneic transplantation: a report from the Center for International Blood and Marrow Transplant Research. Biol Blood Marrow Transplant. 2015;21(2):266–74. + + 10.1016/j.bbmt.2014.10.021 + 25445023 + + + + Flowers ME, Martin PJ. How we treat chronic graft-versus-host disease. Blood. 2015;125(4):606–15. + + 10.1182/blood-2014-08-551994 + 25398933 + 4304105 + + + + Brice L, Gilroy N, Dyer G, Kabir M, Greenwood M, Larsen S, et al. Predictors of quality of life in allogeneic hematopoietic stem cell transplantation survivors. J Psychosoc Oncol. 2021;39(4):534–52. + + 10.1080/07347332.2020.1870644 + 33468039 + + + + Cheon J, Lee YJ, Jo JC, Kweon K, Koh S, Min YJ, et al. Late complications and quality of life assessment for survivors receiving allogeneic hematopoietic stem cell transplantation. Support Care Cancer. 2021;29(2):975–86. + + 10.1007/s00520-020-05572-0 + 32556712 + + + + Hayakawa J, Miyamura D, Kimura SI, Gomyo A, Tamaki M, Akahoshi Y, et al. Negative impact of chronic graft-versus-host disease and glucocorticoid on the recovery of physical function after allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant. 2019;54(7):994–1003. + + 10.1038/s41409-018-0365-4 + 30337699 + + + + Kurosawa S, Yamaguchi T, Oshima K, Yanagisawa A, Fukuda T, Kanamori H, et al. Resolved versus Active Chronic Graft-versus-Host Disease: Impact on Post-Transplantation Quality of Life. Biol Blood Marrow Transplant. 2019;25(9):1851–8. + + 10.1016/j.bbmt.2019.05.016 + 31129353 + + + + Yu J, Hamilton BK, Turnbull J, Stewart SK, Vernaya A, Bhatt V, et al Patient-reported symptom burden and impact on daily activities in chronic graft-versus-host disease. Cancer Med. 2023;12(3):3623–33. + + + Lynch Kelly D, Lyon DE, Ameringer SA, Elswick RK. Symptoms, Cytokines, and Quality of Life in Patients Diagnosed with Chronic Graft-Versus-Host Disease Following Allogeneic Hematopoietic Stem Cell Transplantation. Oncol Nurs Forum. 2015;42(3):265–75. + + 10.1188/15.ONF.265-275 + 25901378 + + + + Pidala J, Kurland B, Chai X, Majhail N, Weisdorf DJ, Pavletic S, et al. Patient-reported quality of life is associated with severity of chronic graft-versus-host disease as measured by NIH criteria: report on baseline data from the Chronic GVHD Consortium. Blood. 2011;117(17):4651–7. + + 10.1182/blood-2010-11-319509 + 21355084 + 3099579 + + + + Wenzel F, Pralong A, Holtick U, Scheid C, Herling M, Simon ST. Burden and Needs of Patients with Severe GvHD from the Supportive and Palliative Care Perspective-A Literature Review. Cancers (Basel). 2021; 13(11). + + + Jim HS, Sutton SK, Jacobsen PB, Martin PJ, Flowers ME, Lee SJ. Risk factors for depression and fatigue among survivors of hematopoietic cell transplantation. Cancer. 2016;122(8):1290–7. + + 10.1002/cncr.29877 + 26814442 + + + + Baird K, Steinberg SM, Grkovic L, Pulanic D, Cowen EW, Mitchell SA, et al. National Institutes of Health chronic graft-versus-host disease staging in severely affected patients: organ and global scoring correlate with established indicators of disease severity and prognosis. Biol Blood Marrow Transplant. 2013;19(4):632–9. + + 10.1016/j.bbmt.2013.01.013 + 23340040 + 3619213 + + + + Kurosawa S, Oshima K, Yamaguchi T, Yanagisawa A, Fukuda T, Kanamori H, et al. Quality of Life after Allogeneic Hematopoietic Cell Transplantation According to Affected Organ and Severity of Chronic Graft-versus-Host Disease. Biol Blood Marrow Transplant. 2017;23(10):1749–58. + + 10.1016/j.bbmt.2017.06.011 + 28669922 + + + + El-Jawahri A, Pidala J, Khera N, Wood WA, Arora M, Carpenter PA, et al. Impact of Psychological Distress on Quality of Life, Functional Status, and Survival in Patients with Chronic Graft-versus-Host Disease. Biol Blood Marrow Transplant. 2018;24(11):2285–92. + + 10.1016/j.bbmt.2018.07.020 + 30031937 + + + + Jacobs JM, Fishman S, Sommer R, Sereno I, Fenech A, Jankowski AL, et al. Coping and Modifiable Psychosocial Factors are Associated with Mood and Quality of Life in Patients with Chronic Graft-versus-Host Disease. Biol Blood Marrow Transplant. 2019;25(11):2234–42. + + 10.1016/j.bbmt.2019.06.024 + 31260800 + + + + Gruber I, Koelbl O, Herr W, Holler E, Edinger M, Wolff D. Impact of chronic graft-versus-host disease on quality of life and cognitive function of long-term transplant survivors after allogeneic hematopoietic stem cell transplantation with total body irradiation. Radiat Oncol. 2022;17(1):195. + + 10.1186/s13014-022-02161-9 + 36447269 + 9706937 + + + + Wolff D, Herzberg PY, Herrmann A, Pavletic SZ, Heussner P, Mumm F, et al. Post-transplant multimorbidity index and quality of life in patients with chronic graft-versus-host disease-results from a joint evaluation of a prospective German multicenter validation trial and a cohort from the National Institutes of Health. Bone Marrow Transplant. 2021;56(1):243–56. + + 10.1038/s41409-020-01017-8 + 32737446 + + + + Kelly DL, Syrjala K, Taylor M, Rentscher KE, Hashmi S, Wood WA, et al. Biobehavioral Research and Hematopoietic Stem Cell Transplantation: Expert Review from the Biobehavioral Research Special Interest Group of the American Society for Transplantation and Cellular Therapy. Transplant Cell Ther. 2021;27(9):747–57. + + 10.1016/j.jtct.2021.06.007 + 34139388 + 8428782 + + + + Watson D, O’Hara MW, Simms LJ, Kotov R, Chmielewski M, McDade-Montez EA, et al. Development and validation of the Inventory of Depression and Anxiety Symptoms (IDAS). 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+ + + 36917442 + + 2023 + 03 + 14 + +
+ + 1522-1709 + + + 2023 + Mar + 14 + + + Sleep & breathing = Schlaf & Atmung + Sleep Breath + + Upregulation of peripheral blood mononuclear cells resistin gene expression in severe obstructive sleep apnea and obstructive sleep apnea with coexisting type 2 diabetes mellitus. + 10.1007/s11325-023-02809-0 + + Obstructive sleep apnea (OSA) is characterised by increased systemic inflammation, and is often accompanied with type 2 diabetes mellitus (T2DM) and cardiovascular disease. The aim of this investigation was to evaluate gene expression of resistin, its receptor CAP1 and CD36 as the indicators of the inflammatory changes in PBMCs in relation to the severity of OSA, and the presence of type 2 diabetes mellitus (T2DM) in OSA. + Severity of OSA was defined by the apnea/hypopnea index (AHI): AHI < 30: mild to moderate OSA (MM-OSA), AHI ≥ 30: severe OSA (S-OSA). Presence of T2DM was captured: OSA with T2DM (OSA + T2DM), OSA without T2DM (OSA-T2DM). PBMC resistin, CAP1, and CD36 mRNA were determined by real-time PCR. + Resistin mRNA was significantly upregulated in S-OSA (N = 54) compared to the MM-OSA (N = 52, P = 0.043); CAP1 and CD36 mRNA levels did not differ between the groups (P = 0.302; P = 0.166, respectively). Resistin mRNA was significantly upregulated in OSA + T2DM (N = 29) compared to the OSA-T2DM (N = 77, P = 0.029); CAP1 and CD36 mRNA levels did not differ between the groups (P = 0.662; P = 0.108, respectively). AHI and T2DM were independent predictors of resistin mRNA above the 75th percentile (OR = 3.717 [1.152-11.991]; OR = 3.261 [1.000-10.630], P = 0.042 respectively). + Resistin gene upregulation in S-OSA indicates its possible contribution to increased inflammation in S-OSA and makes it a possible marker of the disease severity. Resistin gene upregulation in OSA + T2DM suggests that a joint effect of these two comorbidities may have a major contribution to increased inflammation and complications that arise from this state. + © 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG. + + + + Rajkov + Branislava + B + + Department of Medical Biochemistry, University of Belgrade - Faculty of Pharmacy, Belgrade, Serbia. + + + + Zdravković + Marija + M + + Department of Cardiology, University Medical Center "Bežanijska Kosa", Belgrade, Serbia. + + + Faculty of Medicine, University of Belgrade, Belgrade, Serbia. + + + + Ninić + Ana + A + http://orcid.org/0000-0003-3838-1606 + + Department of Medical Biochemistry, University of Belgrade - Faculty of Pharmacy, Belgrade, Serbia. aninic@pharmacy.bg.ac.rs. + + + + Brajković + Milica + M + + Department of Pulmology, University Medical Center "Bežanijska Kosa", Belgrade, Serbia. + + + + Klašnja + Slobodan + S + + Department of Cardiology, University Medical Center "Bežanijska Kosa", Belgrade, Serbia. + + + + Gardijan + Vera + V + + Department of Pulmology, University Medical Center "Bežanijska Kosa", Belgrade, Serbia. + + + + Memon + Lidija + L + + Department of Laboratory Diagnostics, University Medical Center "Bežanijska Kosa", Belgrade, Serbia. + + + + Munjas + Jelena + J + http://orcid.org/0000-0002-4576-1722 + + Department of Medical Biochemistry, University of Belgrade - Faculty of Pharmacy, Belgrade, Serbia. jelenaj@pharmacy.bg.ac.rs. + + + + Mihajlović + Marija + M + + Department of Medical Biochemistry, University of Belgrade - Faculty of Pharmacy, Belgrade, Serbia. + + + + Spasojević-Kalimanovska + Vesna + V + + Department of Medical Biochemistry, University of Belgrade - Faculty of Pharmacy, Belgrade, Serbia. + + + + Radosavljević + Vojislav + V + + Department of Pulmology, University Medical Center "Bežanijska Kosa", Belgrade, Serbia. + + + + Sopić + Miron + M + http://orcid.org/0000-0003-3283-9487 + + Department of Medical Biochemistry, University of Belgrade - Faculty of Pharmacy, Belgrade, Serbia. miron.sopic@pharmacy.bg.ac.rs. + + + + eng + + + 175035 + Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Sleep Breath + 9804161 + 1520-9512 + + IM + + CAP1 + CD36 + Obstructive sleep apnea + Resistin + +
+ + + + 2021 + 12 + 14 + + + 2023 + 03 + 06 + + + 2023 + 02 + 27 + + + 2023 + 3 + 14 + 12 + 22 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917442 + 10.1007/s11325-023-02809-0 + 10.1007/s11325-023-02809-0 + + + + Semelka M, Wilson J, Floyd R (2016) Diagnosis and treatment of obstructive sleep apnea in adults. Am Fam Physician 94:355–360 + + 27583421 + + + + Maspero C, Giannini L, Galbiati G, Rosso G, Farronato G (2015) Obstructive sleep apnea syndrome: a literature review. Minerva Stomatol 64:97–109 + + 25747430 + + + + Jordan AS, McSharry DG, Malhotra A (2014) Adult obstructive sleep apnoea. Lancet 383:736–747. https://doi.org/10.1016/S0140-6736(13)60734-5 + + 10.1016/S0140-6736(13)60734-5 + 23910433 + + + + Park JG, Ramar K, Olson EJ (2011) Updates on definition, consequences, and management of obstructive sleep apnea. 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Exp Mol Med 46:e99-e. https://doi.org/10.1038/emm.2014.38 + + 10.1038/emm.2014.38 + + + + Gileles-Hillel A, Almendros I, Khalyfa A, Zhang SX, Wang Y, Gozal D (2014) Early intermittent hypoxia induces proatherogenic changes in aortic wall macrophages in a murine model of obstructive sleep apnea. Am J Respir Crit Care Med 190:958–961. https://doi.org/10.1164/rccm.201406-1149LE + + 10.1164/rccm.201406-1149LE + 25317468 + 4299581 + + + + Veasey SC, Rosen IM (2019) Obstructive Sleep Apnea in Adults. N Engl J Med 380:1442–1449. https://doi.org/10.1056/NEJMcp1816152 + + 10.1056/NEJMcp1816152 + 30970189 + + + + (1997) Practice parameters for the indications for polysomnography and related procedures. Polysomnography Task Force, American Sleep Disorders Association Standards of Practice Committee. Sleep 20:406–422 + + + Cosentino F, Grant PJ, Aboyans V, Bailey CJ, Ceriello A, Delgado V, Federici M, Filippatos G, Grobbee DE, Hansen TB, Huikuri HV, Johansson I, Jüni P, Lettino M, Marx N, Mellbin LG, Östgren CJ, Rocca B, Roffi M, Sattar N … ESC Scientific Document Group (2020) 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD. Eur Heart J 41(2): 255–323. https://doi.org/10.1093/eurheartj/ehz486 + + + Munjas J, Sopić M, Spasojević-Kalimanovska V, Kalimanovska-Oštrić D, Anđelković K, Jelić-Ivanović Z (2017) Association of adenylate cyclase-associated protein 1 with coronary artery disease. Eur J Clin Invest 47:659–666. https://doi.org/10.1111/eci.12787 + + 10.1111/eci.12787 + 28707728 + + + + Vujovic A, Spasojevic-Kalimanovska V, Bogavac-Stanojevic N, Spasic S, Kotur- Stevuljevic J, Jelic-Ivanovic Z (2013) Comparison of two RNA isolation methods for determination of SOD1 and SOD2 gene expression in human blood and mononuclear cells. Indian J Biotechnol 12:468–474 + + + Unger T, Borghi C, Charchar F, Khan NA, Poulter NR, Prabhakaran D, Ramirez A, Schlaich M, Stergiou GS, Tomaszewski M, Wainford RD (2020) 2020 International Society of Hypertension global hypertension practice guidelines. Hypertension 75:1334–1357 + + 10.1161/HYPERTENSIONAHA.120.15026 + 32370572 + + + + Chesnaye NC, Stel VS, Tripepi G, Dekker FW, Fu EL, Zoccali C, Jager KJ (2022) An introduction to inverse probability of treatment weighting in observational research. Clin Kidney J 15:14–20. https://doi.org/10.1093/ckj/sfab158 + + 10.1093/ckj/sfab158 + 35035932 + + + + Austin PC, Stuart EA (2015) Moving towards best practice when using inverse probability of treatment weighting (IPTW) using the propensity score to estimate causal treatment effects in observational studies. Stat Med. 34(28):3661–79. https://doi.org/10.1002/sim.6607 + + 10.1002/sim.6607 + 26238958 + 4626409 + + + + Kimura H, Ota H, Kimura Y, Takasawa S (2019) Effects of intermittent hypoxia on pulmonary vascular and systemic diseases. Int J Environ Res Public Health 16:3101. https://doi.org/10.3390/ijerph16173101 + + 10.3390/ijerph16173101 + 31455007 + 6747246 + + + + Lévy P, Pépin JL, Arnaud C, Baguet JP, Dematteis M, Mach F (2009) Obstructive sleep apnea and atherosclerosis. Prog Cardiovasc Dis 51:400–410. https://doi.org/10.1016/j.pcad.2008.03.001 + + 10.1016/j.pcad.2008.03.001 + 19249446 + + + + Yamamoto Y, Fujiuchi S, Hiramatsu M, Nishigaki Y, Takeda A, Fujita Y, Yamazaki Y (2008) Resistin is closely related to systemic inflammation in obstructive sleep apnea. Respiration 76:377–385. https://doi.org/10.1159/000141866 + + 10.1159/000141866 + 18577878 + + + + Uchiyama T, Itaya-Hironaka A, Yamauchi A, Makino M, Sakuramoto-Tsuchida S, Shobatake R, Ota H, Takeda M, Ohbayashi C, Takasawa S (2019) Intermittent Hypoxia Up-Regulates CCL2, RETN, and TNFα mRNAs in Adipocytes via Down-regulation of miR-452. Int J Mol Sci 20:1960. https://doi.org/10.3390/ijms20081960 + + 10.3390/ijms20081960 + 31013606 + 6515141 + + + + Park HK, Ahima RS (2013) Resistin in rodents and humans. 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Future Cardiol 14:491–509. https://doi.org/10.2217/fca-2018-0045 + + 10.2217/fca-2018-0045 + 30409037 + + + + Cho Y, Lee SE, Lee HC, Hur J, Lee S, Youn SW, Lee J, Lee HJ, Lee TK, Park J, Hwang SJ, Kwon YW, Cho HJ, Oh BH, Park YB, Kim HS (2011) Adipokine resistin is a key player to modulate monocytes, endothelial cells, and smooth muscle cells, leading to progression of atherosclerosis in rabbit carotid artery. J Am Coll Cardiol 57:99–109. https://doi.org/10.1016/j.jacc.2010.07.035 + + 10.1016/j.jacc.2010.07.035 + 21185508 + + + + +
+ + + 36917441 + + 2023 + 03 + 14 + +
+ + 1568-5888 + + + 2023 + Mar + 14 + + + Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation + Neth Heart J + + Clinical decision rules in the pre-hospital triage of patients with chest pain. + 10.1007/s12471-023-01769-0 + + + Aarts + Goaris W A + GWA + + Department of Cardiology, Radboud University Medical Centre, Nijmegen, The Netherlands. + + + + Damman + Peter + P + http://orcid.org/0000-0003-0888-5176 + + Department of Cardiology, Radboud University Medical Centre, Nijmegen, The Netherlands. peter.damman@radboudumc.nl. + + + + eng + + Editorial + + + 2023 + 03 + 14 + +
+ + Netherlands + Neth Heart J + 101095458 + 1568-5888 + +
+ + + + 2023 + 02 + 16 + + + 2023 + 3 + 14 + 12 + 22 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917441 + 10.1007/s12471-023-01769-0 + 10.1007/s12471-023-01769-0 + + + + Collet JP, Thiele H, Barbato E, et al. 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Eur Heart J. 2021;42:1289–367. + + 10.1093/eurheartj/ehaa575 + 32860058 + + + + Nasrallah N, Steiner H, Hasin Y. The challenge of chest pain in the emergency room: now and the future. Eur Heart J. 2011;32:656. + + 21523940 + + + + Wouters LT, Rutten FH, Erkelens DC, De Groot E, Damoiseaux RA, Zwart DL. Accuracy of telephone triage in primary care patients with chest discomfort: a cross-sectional study. Open Heart. 2020;7:e1376. + + 10.1136/openhrt-2020-001376 + 32958556 + 7507892 + + + + Manten A, De Clercq L, Rietveld RP, Lucassen WAM, Moll van Charante EP, Harskamp RE. Evaluation of the Marburg Heart Score and INTERCHEST score compared to current telephone triage for chest pain in out-of-hours primary care. Neth Heart J. 2022; https://doi.org/10.1007/s12471-022-01745-0 . + + 10.1007/s12471-022-01745-0 + 36580267 + + + + Six AJ, Backus BE, Kelder JC. Chest pain in the emergency room: value of the HEART score. Neth Heart J. 2008;16:191–6. + + 10.1007/BF03086144 + 18665203 + 2442661 + + + + Harskamp RE, Kleton M, Smits IH, et al. Performance of a simplified HEART score and HEART-GP score for evaluating chest pain in urgent primary care. Neth Heart J. 2021;29:338–47. + + 10.1007/s12471-020-01529-4 + 33405015 + 8160073 + + + + Tolsma RT, Fokkert MJ, van Dongen DN, et al. Referral decisions based on a pre-hospital HEART score in suspected non-ST-elevation acute coronary syndrome: final results of the FamouS Triage study. Eur Heart J Acute Cardiovasc Care. 2022;11:160–9. + + 10.1093/ehjacc/zuab109 + 34849660 + + + + Camaro C, Aarts GWA, Adang EMM, et al. Rule-out of non-ST-segment elevation acute coronary syndrome by a single pre-hospital troponin measurement: a randomised trial. Eur Heart J. 2023. https://doi.org/10.1093/eurheartj/ehad056 . + + + +
+ + + 36917448 + + 2023 + 03 + 14 + +
+ + 1469-896X + + + 2023 + Mar + 14 + + + Protein science : a publication of the Protein Society + Protein Sci + + A splicing variant of EDS1 from Vitis vinifera forms homodimers but no heterodimers with PAD4. + + e4624 + + 10.1002/pro.4624 + + Enhanced Disease Susceptibility 1 (EDS1), a key component of microbe-triggered immunity (MTI) and effector-triggered immunity (ETI) in most higher plants, forms functional heterodimeric complexes with its homologs Phytoalexin-Deficient 4 (PAD4) or Senescence-Associated Gene 101 (SAG101). Here, the crystal structure of VvEDS1Nterm , the N-terminal domain of EDS1 from Vitis vinifera, is reported, representing the first structure of an EDS1 entity beyond the model plant Arabidopsis thaliana. VvEDS1Nterm has an α/β-hydrolase fold, is similar to the N-terminal domain of A. thaliana EDS1 and forms stable homodimers in solution as well as in crystals. These VvEDS1Nterm homodimers are spatially incompatible with heterodimers with PAD4 or SAG101, they explain why VvEDS1Nterm does not interact with Vitis vinifera PAD4 according to gel filtration, and they serve as a guide to develop a plausible, albeit experimentally not verified model of full-length VvEDS1. VvEDS1Nterm is a splicing variant comprising two of three exons of the VvEDS1 gene. It originates from a naturally occurring mRNA, in which the first of two introns was removed while the second one containing a stop codon close to the exon/intron border was retained. This is a potential case of intron retention and the first report of this phenomenon in the context of EDS1. Its biological significance has not yet been clarified, nor has the question if a VvEDS1Nterm protein with a specific function can occur under physiological conditions. This article is protected by copyright. All rights reserved. + © 2023 The Protein Society. + + + + Voss + Martin + M + + Universität zu Köln, Department für Chemie, Institut für Biochemie, Zülpicher Straße 47, D-50674, Köln, Germany. + + + + Cseke + Leland J + LJ + + University of Missouri, Division of Plant Science and Technology, Interdisciplinary Plant Group, and CS Bond Life Sciences Center, Columbia, MO, 65211-7310, USA. + + + + Gassmann + Walter + W + + University of Missouri, Division of Plant Science and Technology, Interdisciplinary Plant Group, and CS Bond Life Sciences Center, Columbia, MO, 65211-7310, USA. + + + + Niefind + Karsten + K + https://orcid.org/0000-0002-0183-6315 + + Universität zu Köln, Department für Chemie, Institut für Biochemie, Zülpicher Straße 47, D-50674, Köln, Germany. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Protein Sci + 9211750 + 0961-8368 + + IM + + EDS1 homodimerization + Enhanced Disease Susceptibility 1 + Phytoalexin-Deficient 4 + Vitis vinifera + alternative splicing + intron retention + plant innate immune system + +
+ + + + 2023 + 03 + 06 + + + 2022 + 11 + 30 + + + 2023 + 03 + 10 + + + 2023 + 3 + 14 + 12 + 23 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917448 + 10.1002/pro.4624 + + +
+ + + 36917447 + + 2023 + 03 + 14 + +
+ + 1364-548X + + + 2023 + Mar + 14 + + + Chemical communications (Cambridge, England) + Chem Commun (Camb) + + Synthesis of unconventional Pd-Se nanoparticles for phase-dependent ethanol electrooxidation. + 10.1039/d2cc06785d + + By tuning the amount of the Se precursors during the synthesis, orthorhombic PdSe2, cubic Pd17Se15, and monoclinic Pd7Se2 nanoparticles are synthesized, which show phase-dependent electrocatalysis for the ethanol oxidation reaction. This work advances the controllable synthesis of transition metal selenides and inspires their applications in electrocatalysis. + + + + Hu + Zhenya + Z + + State Key Laboratory of Multiphase Complex Systems, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China. liuhui@ipe.ac.cn. + + + Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing, 100049, China. + + + + Yang + Niuwa + N + + State Key Laboratory of Multiphase Complex Systems, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China. liuhui@ipe.ac.cn. + + + Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing, 100049, China. + + + + Feng + Yongjun + Y + http://orcid.org/0000-0001-9254-6219 + + State Key Laboratory of Chemical Resource Engineering, Beijing Engineering Center for Hierarchical Catalysts, College of Chemistry, Beijing University of Chemical Technology, No. 15 Beisanhuan East Road, Beijing, 100029, China. + + + + Xu + Lin + L + http://orcid.org/0000-0002-3301-2839 + + School of Chemistry and Materials Science, Jiangsu Key Laboratory of New Power Batteries, Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials, Nanjing Normal University, Nanjing, 210023, P. R. China. + + + + Hu + Chaoquan + C + http://orcid.org/0000-0003-0906-2788 + + State Key Laboratory of Multiphase Complex Systems, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China. liuhui@ipe.ac.cn. + + + Nanjing IPE Institute of Green Manufacturing Industry, Nanjing, 211100, Jiangsu, China. + + + + Liu + Hui + H + + State Key Laboratory of Multiphase Complex Systems, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China. liuhui@ipe.ac.cn. + + + Nanjing IPE Institute of Green Manufacturing Industry, Nanjing, 211100, Jiangsu, China. + + + + Tian + Shaonan + S + + State Key Laboratory of Multiphase Complex Systems, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China. liuhui@ipe.ac.cn. + + + + Yang + Jun + J + http://orcid.org/0000-0002-8993-0655 + + State Key Laboratory of Multiphase Complex Systems, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China. liuhui@ipe.ac.cn. + + + Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing, 100049, China. + + + Nanjing IPE Institute of Green Manufacturing Industry, Nanjing, 211100, Jiangsu, China. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + England + Chem Commun (Camb) + 9610838 + 1359-7345 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 23 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917447 + 10.1039/d2cc06785d + + +
+ + + 36917445 + + 2023 + 03 + 14 + +
+ + 1467-7652 + + + 2023 + Mar + 14 + + + Plant biotechnology journal + Plant Biotechnol J + + Depletion of the NbCORE receptor drastically improves agroinfiltration productivity in older Nicotiana benthamiana plants. + 10.1111/pbi.14037 + + Nicotiana benthamiana is increasingly used for transient gene expression to produce antibodies, vaccines, and other pharmaceutical proteins but transient gene expression is low in fully developed, 6-8-week old plants. This low gene expression is thought to be caused by the perception of the cold shock protein (CSP) of Agrobacterium tumefaciens. The CSP receptor is contested because both NbCSPR and NbCORE have been claimed to perceive CSP. Here, we demonstrate that CSP perception is abolished in 6-week-old plants silenced for NbCORE but not NbCSPR. Importantly, older NbCORE-silenced plants support a highly increased level of GFP fluorescence and protein upon agroinfiltration. The drastic increase in transient protein production in NbCORE-depleted plants offers new opportunities for molecular farming, where older plants with larger biomass can now be used for efficient protein expression. + © 2023 The Authors. Plant Biotechnology Journal published by Society for Experimental Biology and The Association of Applied Biologists and John Wiley & Sons Ltd. + + + + Dodds + Isobel + I + https://orcid.org/0000-0002-7818-5493 + + The Plant Chemetics Laboratory, Department of Biology, University of Oxford, Oxford, UK. + + + + Chen + Changlong + C + https://orcid.org/0000-0001-5630-2110 + + The Plant Chemetics Laboratory, Department of Biology, University of Oxford, Oxford, UK. + + + Beijing Academy of Agriculture and Forestry Sciences, Beijing, China. + + + Beijing Key Laboratory of Agricultural Genetic Resources and Biotechnology, Institute of Biotechnology, Beijing, China. + + + + Buscaill + Pierre + P + https://orcid.org/0000-0003-4756-1203 + + The Plant Chemetics Laboratory, Department of Biology, University of Oxford, Oxford, UK. + + + + van der Hoorn + Renier A L + RAL + https://orcid.org/0000-0002-3692-7487 + + The Plant Chemetics Laboratory, Department of Biology, University of Oxford, Oxford, UK. + + + + eng + + + BB/R017913/1 + BB_ + Biotechnology and Biological Sciences Research Council + United Kingdom + + + DTP DDT00060 + BB_ + Biotechnology and Biological Sciences Research Council + United Kingdom + + + Chinese Scholarship Council + + + + 101019324 + H2020 European Research Council + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + England + Plant Biotechnol J + 101201889 + 1467-7644 + + IM + + Agrobacterium tumefaciens + CORE receptor + Nicotiana benthamiana + agroinfiltration + cold shock protein + transient GFP expression + +
+ + + + 2023 + 02 + 09 + + + 2022 + 10 + 21 + + + 2023 + 02 + 24 + + + 2023 + 3 + 14 + 12 + 22 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917445 + 10.1111/pbi.14037 + + + References + + Bally, J., Jung, H., Mortimer, C., Naim, F., Philips, J.G., Hellens, R., Bombarely, A. et al. (2018) The rise and rise of Nicotiana benthamiana: a plant for all reasons. Annu. Rev. Phytopathol. 56, 405-426. + + + Felix, G. and Boller, T. (2003) Molecular sensing of bacteria in plants. The highly conserved RNA-binding motif RNP-1 of bacterial cold shock proteins is recognized as an elicitor signal in tobacco. J. Biol. Chem. 278, 6201-6208. + + + Kourelis, J., Marchal, C. and Kamoun, S. (2021) NLR immune receptor-nanobody fusions confer plant disease resistance. bioRxiv. 2021.10.24.465418. + + + Lai, H. and Chen, Q. (2012) Bioprocessing of plant-derived virus-like particles of Norwalk virus capsid protein under current Good Manufacture Practice regulations. Plant Cell Rep. 31, 573-584. + + + Nie, J., Zhou, W., Liu, J., Tan, N., Zhou, J.M. and Huang, L. (2021) A receptor-like protein from Nicotiana benthamiana mediates VmE02 PAMP-triggered immunity. New Phytol. 229, 2260-2272. + + + Sainsbury, F. (2020) Innovation in plant-based transient protein expression for infectious disease prevention and preparedness. Curr. Opin. Biotechnol. 61, 110-115. + + + Saur, I.M., Kadota, Y., Sklenar, J., Holton, N.J., Smakowska, E., Belkhadir, Y., Zipfel, C. et al. (2016) NbCSPR underlies age-dependent immune responses to bacterial cold shock protein in Nicotiana benthamiana. Proc. Natl. Acad. Sci. U. S. A. 113, 3389-3394. + + + Schillberg, S. and Spiegel, H. (2022) Recombinant protein production in plants: a brief overview of strengths and challenges. Methods Mol. Biol. 2480, 1-13. + + + Wang, L., Albert, M., Einig, E., Fürst, U., Krust, D. and Felix, G. (2016) The pattern-recognition receptor CORE of Solanaceae detects bacterial cold-shock protein. Nat Plants. 2, 16185. + + + Wei, Y., Caceres-Moreno, C., Jimenez-Gongora, T., Wang, K., Sang, Y., Lozano-Duran, R. and Macho, A.P. (2018) The Ralstonia solanacearum csp22 peptide, but not flagellin-derived peptides, is perceived by plants from the Solanaceae family. Plant Biotechnol. J. 16, 1349-1362. + + + +
+ + + 36917449 + + 2023 + 03 + 14 + +
+ + 1715-6580 + + 18 + 3 + + 2023 + Feb + + + Healthcare policy = Politiques de sante + Healthc Policy + + Provinces and Territories Are Overdue for an Update in Healthcare Funding Policies. + + 6-16 + + hcpol.2023.27039 + 10.12927/hcpol.2023.27039 + + Even before the recent funding announcement, the provinces had money earmarked for spending on health services, therapies and devices. Canadians expect that this money will be put to work to improve access to scheduled services and emergency care, to increase capacity of primary care to manage complex conditions and to begin the assembly of patients' health information. This does not represent an exhaustive list as most provinces also have other pressing needs, including access to and quality of long-term care and mental healthcare services. + Copyright © 2022 Longwoods Publishing. + + + + Sutherland + Jason M + JM + + Editor-in-Chief. + + + + eng + + Journal Article + +
+ + Canada + Healthc Policy + 101280107 + 1715-6572 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 23 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + ppublish + + 36917449 + hcpol.2023.27039 + 10.12927/hcpol.2023.27039 + + +
+ + + 36917431 + + 2023 + 03 + 14 + +
+ + 1559-131X + + 40 + 4 + + 2023 + Mar + 14 + + + Medical oncology (Northwood, London, England) + Med Oncol + + The critical role of circular RNAs in drug resistance in gastrointestinal cancers. + + 116 + + 10.1007/s12032-023-01980-4 + + Nowadays, drug resistance (DR) in gastrointestinal (GI) cancers, as the main reason for cancer-related mortality worldwide, has become a serious problem in the management of patients. Several mechanisms have been proposed for resistance to anticancer drugs, including altered transport and metabolism of drugs, mutation of drug targets, altered DNA repair system, inhibited apoptosis and autophagy, cancer stem cells, tumor heterogeneity, and epithelial-mesenchymal transition. Compelling evidence has revealed that genetic and epigenetic factors are strongly linked to DR. Non-coding RNA (ncRNA) interferences are the most crucial epigenetic alterations explored so far, and among these ncRNAs, circular RNAs (circRNAs) are the most emerging members known to have unique properties. Due to the absence of 5' and 3' ends in these novel RNAs, the two ends are covalently bonded together and are generated from pre-mRNA in a process known as back-splicing, which makes them more stable than other RNAs. As far as the unique structure and function of circRNAs is concerned, they are implicated in proliferation, migration, invasion, angiogenesis, metastasis, and DR. A clear understanding of the molecular mechanisms responsible for circRNAs-mediated DR in the GI cancers will open a new window to the management of GI cancers. Hence, in the present review, we will describe briefly the biogenesis, multiple features, and different biological functions of circRNAs. Then, we will summarize current mechanisms of DR, and finally, discuss molecular mechanisms through which circRNAs regulate DR development in esophageal cancer, pancreatic cancer, gastric cancer, colorectal cancer, and hepatocellular carcinoma. + © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. + + + + Samavarchi Tehrani + Sadra + S + + Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. + + + + Esmaeili + Fataneh + F + + Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. + + + + Shirzad + Moein + M + + Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. + + + + Goodarzi + Golnaz + G + + Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. + + + + Yousefi + Tooba + T + + Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. + + + + Maniati + Mahmood + M + + Department of English, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. + + + + Taheri-Anganeh + Mortaza + M + http://orcid.org/0000-0002-9659-7491 + + Cellular and Molecular Research Center, Cellular and Molecular Medicine Research Institute, Urmia University of Medical Sciences, Urmia, Iran. taheri.m@umsu.ac.ir. + + + + Anushiravani + Amir + A + + Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran. aanushiravani@sina.tums.ac.ir. + + + + eng + + Journal Article + Review + + + 2023 + 03 + 14 + +
+ + United States + Med Oncol + 9435512 + 1357-0560 + + IM + + Drug resistance + Gastrointestinal cancers + circRNAs + +
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Cancer Lett. 2017;388:107–17. + + 27940128 + 10.1016/j.canlet.2016.11.035 + + + + Huang F-T, Zhuan-Sun Y-X, Zhuang Y-Y, Wei S-L, Tang J, Chen W-B, et al. Inhibition of hedgehog signaling depresses self-renewal of pancreatic cancer stem cells and reverses chemoresistance. Int J Oncol. 2012;41(5):1707–14. + + 22923052 + 10.3892/ijo.2012.1597 + + + + Yu C, Chen S, Guo Y, Sun C. Oncogenic TRIM31 confers gemcitabine resistance in pancreatic cancer via activating the NF-κB signaling pathway. Theranostics. 2018;8(12):3224. + + 29930725 + 6010981 + 10.7150/thno.23259 + + + + Giovannetti E, Pacetti P, Reni M, Leon LG, Mambrini A, Vasile E, et al. Association between DNA-repair polymorphisms and survival in pancreatic cancer patients treated with combination chemotherapy. Pharmacogenomics. 2011;12(12):1641–52. + + 22026922 + 10.2217/pgs.11.109 + + + + Yang D, Tang Y, Fu H, Xu J, Hu Z, Zhang Y, et al. Integrin β1 promotes gemcitabine resistance in pancreatic cancer through Cdc42 activation of PI3K p110β signaling. Biochem Biophys Res Commun. 2018;505(1):215–21. + + 30243721 + 10.1016/j.bbrc.2018.09.061 + + + + Liang JX, Ning Z, Gao W, Ling J, Wang A, Luo HF, et al. Ubiquitin-specific protease 22-induced autophagy is correlated with poor prognosis of pancreatic cancer. Oncol Rep. 2014;32(6):2726–34. + + 25241857 + 10.3892/or.2014.3508 + + + + Zhang Z, Han H, Rong Y, Zhu K, Zhu Z, Tang Z, et al. Hypoxia potentiates gemcitabine-induced stemness in pancreatic cancer cells through AKT/Notch1 signaling. J Exp Clin Cancer Res. 2018;37(1):291. + + 30486896 + 6263055 + 10.1186/s13046-018-0972-3 + + + + Zheng X, Carstens JL, Kim J, Scheible M, Kaye J, Sugimoto H, et al. Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer. Nature. 2015;527(7579):525–30. + + 26560028 + 4849281 + 10.1038/nature16064 + + + + +
+ + + 36917456 + + 2023 + 03 + 14 + +
+ + 1530-6992 + + + 2023 + Mar + 14 + + + Nano letters + Nano Lett + + Understanding and Controlling Photothermal Responses in MXenes. + 10.1021/acs.nanolett.2c05001 + + MXenes have the potential for efficient light-to-heat conversion in photothermal applications. To effectively utilize MXenes in such applications, it is important to understand the underlying nonequilibrium processes, including electron-phonon and phonon-phonon couplings. Here, we use transient electron and X-ray diffraction to investigate the heating and cooling of photoexcited MXenes at femtosecond to nanosecond time scales. Our results show extremely strong electron-phonon coupling in Ti3C2-based MXenes, resulting in lattice heating within a few hundred femtoseconds. We also systematically study heat dissipation in MXenes with varying film thicknesses, chemical surface terminations, flake sizes, and annealing conditions. We find that the thermal boundary conductance (TBC) governs the thermal relaxation in films thinner than the optical penetration depth. We achieve a 2-fold enhancement of the TBC, reaching 20 MW m-2 K-1, by controlling the flake size or chemical surface termination, which is promising for engineering heat dissipation in photothermal and thermoelectric applications of the MXenes. + + + + Guzelturk + Burak + B + 0000-0003-1977-6485 + + X-ray Science Division, Argonne National Laboratory, Lemont, Illinois 60439, United States. + + + + Kamysbayev + Vladislav + V + + Department of Chemistry, James Franck Institute, and Pritzker School of Molecular Engineering, University of Chicago, Chicago, Illinois 60637, United States. + + + + Wang + Di + D + + Department of Chemistry, James Franck Institute, and Pritzker School of Molecular Engineering, University of Chicago, Chicago, Illinois 60637, United States. + + + + Hu + Huicheng + H + + Department of Chemistry, James Franck Institute, and Pritzker School of Molecular Engineering, University of Chicago, Chicago, Illinois 60637, United States. + + + + Li + Ruiyu + R + + Department of Chemistry, James Franck Institute, and Pritzker School of Molecular Engineering, University of Chicago, Chicago, Illinois 60637, United States. + + + + King + Sarah B + SB + 0000-0003-0274-9894 + + Department of Chemistry, James Franck Institute, and Pritzker School of Molecular Engineering, University of Chicago, Chicago, Illinois 60637, United States. + + + + Reid + Alexander H + AH + 0000-0002-7587-295X + + SLAC National Accelerator Laboratory, Menlo Park, California 94025, United States. + + + + Lin + Ming-Fu + MF + 0000-0001-8086-2484 + + SLAC National Accelerator Laboratory, Menlo Park, California 94025, United States. + + + + Wang + Xijie + X + + SLAC National Accelerator Laboratory, Menlo Park, California 94025, United States. + + + + Walko + Donald A + DA + + X-ray Science Division, Argonne National Laboratory, Lemont, Illinois 60439, United States. + + + + Zhang + Xiaoyi + X + 0000-0001-9732-1449 + + X-ray Science Division, Argonne National Laboratory, Lemont, Illinois 60439, United States. + + + + Lindenberg + Aaron + A + 0000-0003-3233-7161 + + Department of Materials Science and Engineering, Stanford University, Stanford, California 94305, United States. + + + Stanford Institute for Materials and Energy Sciences, SLAC National Accelerator Laboratory, Menlo Park, California 94025, United States. + + + + Talapin + Dmitri V + DV + 0000-0002-6414-8587 + + Department of Chemistry, James Franck Institute, and Pritzker School of Molecular Engineering, University of Chicago, Chicago, Illinois 60637, United States. + + + Center for Nanoscale Materials, Argonne National Laboratory, Lemont, Illinois 60439, United States. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Nano Lett + 101088070 + 1530-6984 + + IM + + MXenes + Ti3C2Tx + photothermal properties + time-resolved X-ray scattering + ultrafast electron diffraction + +
+ + + + 2023 + 3 + 14 + 12 + 23 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917456 + 10.1021/acs.nanolett.2c05001 + + +
+ + + 36917457 + + 2023 + 03 + 14 + +
+ + 1520-6890 + + + 2023 + Mar + 14 + + + Chemical reviews + Chem Rev + + Strategies and Lessons Learned from Total Synthesis of Taxol. + 10.1021/acs.chemrev.2c00763 + + Taxol (paclitaxel), the most well-known taxane diterpenoid, is the best-selling natural-source anticancer drug ever produced and one of the most common prescriptions in the treatment of breast, lung, and ovarian cancers, saving countless lives around the world. Structurally, Taxol possesses a highly oxygenated [6-8-6-4] core bearing 11 stereocenters, seven of which are contiguous chiral centers. Moreover, the extremely strained bicyclo[5.3.1] undecane ring system with a bridgehead double bond is a unique structural feature. All these features make Taxol a highly challenging synthetic target. Tremendous synthetic efforts from more than 60 research groups around the world have already culminated in ten total syntheses and three formal syntheses, as well as more than 60 synthetic model studies of Taxol. This review is intended to provide a long-overdue appraisal of the great achievements in the total syntheses of Taxol reported in the last few decades. In doing so, we summarize the development of synthesis toward Taxol from 1994 to 2022, including the evolution of synthetic strategy for accessing this complex molecular scaffold and key lessons learned from such endeavors. Finally, we briefly discuss the future of the research in this area. + + + + Min + Long + L + + Shenzhen Grubbs Institute and Department of Chemistry, Southern University of Science and Technology (SUSTech), Shenzhen 518055, China. + + + + Han + Jing-Chun + JC + + Shenzhen Grubbs Institute and Department of Chemistry, Southern University of Science and Technology (SUSTech), Shenzhen 518055, China. + + + + Zhang + Wen + W + 0000-0003-4504-7438 + + Shenzhen Grubbs Institute and Department of Chemistry, Southern University of Science and Technology (SUSTech), Shenzhen 518055, China. + + + + Gu + Chen-Chen + CC + + Shenzhen Grubbs Institute and Department of Chemistry, Southern University of Science and Technology (SUSTech), Shenzhen 518055, China. + + + + Zou + Yun-Peng + YP + + Shenzhen Grubbs Institute and Department of Chemistry, Southern University of Science and Technology (SUSTech), Shenzhen 518055, China. + + + + Li + Chuang-Chuang + CC + 0000-0003-4344-0498 + + Shenzhen Grubbs Institute and Department of Chemistry, Southern University of Science and Technology (SUSTech), Shenzhen 518055, China. + + + Shenzhen Bay Laboratory, Shenzhen 518132, China. + + + + eng + + Journal Article + Review + + + 2023 + 03 + 14 + +
+ + United States + Chem Rev + 2985134R + 0009-2665 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 23 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917457 + 10.1021/acs.chemrev.2c00763 + + +
+ + + 36917462 + + 2023 + 03 + 14 + +
+ + 1936-7163 + + 0 + 0 + + 2023 + Mar + 14 + + + Quintessence international (Berlin, Germany : 1985) + Quintessence Int + + Patient-reported outcome measures (PROMs) of leucocyte and platelet-rich fibrin (L-PRF) or hemostatic agent application at palatal donor sites after free gingival graft harvesting: a randomized controlled clinical trial. + + 0 + + 10.3290/j.qi.b3957615 + + The aim of this study was to evaluate the patient's morbidity and post-surgical complications after treatment of palatal donor sites after free gingival graft (FGG) harvesting using Leucocyte-and Platelet Rich Fibrin (L-PRF) membranes or a hemostatic agent with oxidized and regenerated cellulose. + Forty-two palatal donar sites after FGG haversting in 42 patients were randomly assigned to experimental (L-PRF membrane) or control procedure (hemostatic agent). The primary outcome was postoperative pain related to the wound located at palatal area, while the secondary outcomes were post-operative discomfort, inability to chew, post-operative stress, surgical chair time, thickness of palatal fibromucosa and thickness of FGG. The PROMs were recorded after one week. + After one week, a statistically significant difference was found between groups in terms of post operative stress (p=0.0083). No statistically significant differences in terms of postoperative pain (p=0.326), patient discomfort (p=0.509), inability to chew (p=0.936), surgical chair time (p=0.932) were recorded between test and control group. No statistically significant differences were recorded in terms of thickness of palatal fibromucosa (p=0.647) and thickness of FGG (P=0.756) between groups. Post-surgical wound healing complications (i.e., necrosis or infections) were not observed in both groups. + Within their limitations, the present outcomes indicated that the application of L-PRF membrane at palatal donor sites after FGG harvesting did not produce significant advantages for the patients. + + + + Gatti + Fulvio + F + + + Iorio-Siciliano + Vincenzo + V + + + Scaramuzza + Eliam + E + + + Tallarico + Marco + M + + + Vaia + Emanuele + E + + + Ramaglia + Luca + L + + + Chiapasco + Matteo + M + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Quintessence Int + 0342677 + 0033-6572 + + + analogue pain scale + free gingival graft + morbidity + platelet-rich plasma + wound healing + +
+ + + + 2023 + 3 + 14 + 12 + 32 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917462 + 3957615 + 10.3290/j.qi.b3957615 + + +
+ + + 36917459 + + 2023 + 03 + 14 + +
+ + 1473-5628 + + + 2023 + Mar + 15 + + + Nuclear medicine communications + Nucl Med Commun + + Optimization of Bayesian penalized likelihood reconstruction for 68Ga-prostate-specific membrane antigen-11 PET/computed tomography. + 10.1097/MNM.0000000000001687 + + The objective of this study is to determine the optimal β value for clinical use in digital 68Ga-prostate-specific membrane antigen (PSMA-11) PET/computed tomography (CT) imaging. + 68Ga PSMA PET/CT of 21 patients with prostate cancer were reconstructed using block-sequential regularized expectation maximization (β value of 400-1600) and ordered subsets expectation maximization. Nine independent blinded readers evaluated each reconstruction for overall image quality, noise level and lesion detectability. Maximum standardized uptake value (SUVmax) of the most intense lesion, liver SUVmean and liver SUVSD were recorded. Lesions were then subdivided according to uptake and size; the SUVmax of these lesions were analyzed. + There is a statistically significant correlation between improvement in image quality and β value, with the best being β 1400. This trend was also seen in image noise (P < 0.001), with the least image noise reported with β 1400. Lesion detectability was not significantly different between the different β values (P =  0.6452). There was no statistically significant difference in SUVmax of the most intense lesion (P = 0.9966) and SUVmean of liver background between the different β values (P = 0.9999); however, the SUVSD of the liver background showed a clear trend, with the lowest with β 1400 (P = 0.0008). There was a decreasing trend observed in SUVmax when β values increased from 800 to 1400 for all four subgroups, and this decrease was greatest in small and low uptake lesions. + Bayesian penalized likelihood reconstruction algorithms improve image quality without affecting lesion detectability. A β value of 1400 is optimal. + Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved. + + + + Tang + Charlene Yu Lin + CYL + + Department of Nuclear Medicine and Molecular Imaging, Singapore General Hospital. + + + Duke-NUS Graduate Medical School, Singapore, Singapore. + + + + Lim + Gabriel K Y + GKY + + Department of Nuclear Medicine and Molecular Imaging, Singapore General Hospital. + + + + Chua + Wei Ming + WM + + Department of Nuclear Medicine and Molecular Imaging, Singapore General Hospital. + + + + Ng + Cherie Wei Qi + CWQ + + Department of Nuclear Medicine and Molecular Imaging, Singapore General Hospital. + + + + Koo + Si Xuan + SX + + Department of Nuclear Medicine and Molecular Imaging, Singapore General Hospital. + + + + Goh + Charles Xian-Yang + CX + + Department of Nuclear Medicine and Molecular Imaging, Singapore General Hospital. + + + Duke-NUS Graduate Medical School, Singapore, Singapore. + + + + Thang + Sue Ping + SP + + Department of Nuclear Medicine and Molecular Imaging, Singapore General Hospital. + + + Duke-NUS Graduate Medical School, Singapore, Singapore. + + + + Zaheer + Sumbul + S + + Department of Nuclear Medicine and Molecular Imaging, Singapore General Hospital. + + + Duke-NUS Graduate Medical School, Singapore, Singapore. + + + + Lam + Winnie Wing Chuen + WWC + + Department of Nuclear Medicine and Molecular Imaging, Singapore General Hospital. + + + Duke-NUS Graduate Medical School, Singapore, Singapore. + + + + Huang + Hian Liang + HL + + Department of Nuclear Medicine and Molecular Imaging, Singapore General Hospital. + + + Duke-NUS Graduate Medical School, Singapore, Singapore. + + + + eng + + Journal Article + + + 2023 + 03 + 15 + +
+ + England + Nucl Med Commun + 8201017 + 0143-3636 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 23 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917459 + 10.1097/MNM.0000000000001687 + 00006231-990000000-00134 + + + + Fendler WP, Eiber M, Beheshti M, Bomanji J, Ceci F, Cho S, et al. 68Ga-PSMA PET/CT: joint EANM and SNMMI procedure guideline for prostate cancer imaging: version 1.0. Eur J Nucl Med Mol Imaging 2017; 44:1014–1024. + + + Chang SS. Overview of prostate-specific membrane antigen. Rev Urol 2004; 6:S13–S18. + + + Hope TA, Goodman JZ, Allen IE, Calais J, Fendler WP, Carroll PR. Metaanalysis of 68Ga-PSMA-11 PET accuracy for the detection of prostate cancer validated by histopathology. J Nucl Med 2019; 60:786–793. + + + FDA letter of approval for [68Ga]Ga-PSMA-11. [Internet]. https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/212642Orig1s000TOC.cfm. + + + Fendler WP, Calais J, Eiber M, Flavell RR, Mishoe A, Feng FY, et al. Assessment of 68Ga-PSMA-11 PET accuracy in localizing recurrent prostate cancer: a prospective single-arm clinical trial. JAMA Oncol 2019; 5:856–863. + + + Werner RA, Derlin T, Lapa C, Sheikbahaei S, Higuchi T, Giesel FL, et al. 18F-labeled, PSMA-targeted radiotracers: leveraging the advantages of radiofluorination for prostate cancer molecular imaging. Theranostics 2020; 10:1–16. + + + Liberini V, Pizzuto DA, Messerli M, Orita E, Grünig H, Maurer A, et al. BSREM for brain metastasis detection with 18F-FDG-PET/CT in lung cancer patients. J Digit Imaging 2022; 35:581–593. + + + Ross S. GE healthcare white paper: Q.Clear. GE Healthcare Website [Internet]. http://www.enmodedesign.com/MotionFree/QClear_White_Paper_DOC1474189REV_3_2014_06.pdf. + + + Asma E, Ahn S, Ross SG, Chen A, Manjeshwar RM. Accurate and consistent lesion quantitation with clinically acceptable penalized likelihood images. In: 2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC); 2012. pp. 4062–4066. + + + Teoh EJ, McGowan DR, Macpherson RE, Bradley KM, Gleeson FV. Phantom and clinical evaluation of the Bayesian penalized likelihood reconstruction algorithm Q.Clear on an LYSO PET/CT system. J Nucl Med 2015; 56:1447–1452. + + + Matti A, Lima GM, Pettinato C, Pietrobon F, Martinelli F, Fanti S. How do the more recent reconstruction algorithms affect the interpretation criteria of PET/CT images? Nucl Med Mol Imaging 2019; 53:216–222. + + + Witkowska-Patena E, Budzyńska A, Giżewska A, Dziuk M, Walęcka-Mazur A. Ordered subset expectation maximisation vs Bayesian penalised likelihood reconstruction algorithm in 18F-PSMA-1007 PET/CT. Ann Nucl Med 2020; 34:192–199. + + + Eiber M, Herrmann K, Calais J, Hadaschik B, Giesel FL, Hartenbach M, et al. Prostate cancer molecular imaging standardized evaluation (PROMISE): proposed miTNM classification for the interpretation of PSMA-ligand PET/CT. J Nucl Med 2018; 59:469–478. + + + Schwartz LH, Litière S, de Vries E, Ford R, Gwyther S, Mandrekar S, et al. RECIST 1.1 – update and clarification: from the RECIST committee. Eur J Cancer 2016; 62:132–137. + + + Teoh EJ, McGowan DR, Schuster DM, Tsakok MT, Gleeson FV, Bradley KM. Bayesian penalised likelihood reconstruction (Q.Clear) of 18F-fluciclovine PET for imaging of recurrent prostate cancer: semi-quantitative and clinical evaluation. Br J Radiol 2018; 91:20170727. + + + Conti M, Eriksson L. Physics of pure and non-pure positron emitters for PET: a review and a discussion. EJNMMI Phys 2016; 3:8. + + + Rowley LM, Bradley KM, Boardman P, Hallam A, McGowan DR. Optimization of image reconstruction for 90Y selective internal radiotherapy on a lutetium yttrium orthosilicate PET/CT system using a Bayesian penalized likelihood reconstruction algorithm. J Nucl Med 2017; 58:658–664. + + + ter Voert EEGW, Muehlematter UJ, Delso G, Pizzuto DA, Müller J, Nagel HW, et al. Quantitative performance and optimal regularization parameter in block sequential regularized expectation maximization reconstructions in clinical 68Ga-PSMA PET/MR. EJNMMI Res 2018; 8:70. + + + Hicks RM, Simko JP, Westphalen AC, Nguyen HG, Greene KL, Zhang L, et al. Diagnostic accuracy of 68Ga-PSMA-11 PET/MRI compared with multiparametric MRI in the detection of prostate cancer. Radiology 2018; 289:730–737. + + + Rijnsdorp S, Roef MJ, Arends AJ. Impact of the noise penalty factor on quantification in Bayesian penalized likelihood (Q.Clear) reconstructions of 68Ga-PSMA PET/CT scans. Diagnostics 2021; 11:847. + + + Krokos G, Pike LC, Cook GJR, Marsden PK. Standardisation of conventional and advanced iterative reconstruction methods for Gallium-68 multi-centre PET-CT trials. EJNMMI Phys 2021; 8:52. + + + Otani T, Hosono M, Kanagaki M, Onishi Y, Matsubara N, Kawabata K, et al. Evaluation and optimization of a new PET reconstruction algorithm, Bayesian penalized likelihood reconstruction, for lung cancer assessment according to lesion size. Am J Roentgenol 2019; 213:W50–W56. + + + Wu Z, Guo B, Huang B, Hao X, Wu P, Zhao B, et al. Phantom and clinical assessment of small pulmonary nodules using Q.Clear reconstruction on a silicon-photomultiplier-based time-of-flight PET/CT system. Sci Rep 2021; 11:10328. + + + Howard BA, Morgan R, Thorpe MP, Turkington TG, Oldan J, James OG, et al. Comparison of Bayesian penalized likelihood reconstruction versus OS-EM for characterization of small pulmonary nodules in oncologic PET/CT. Ann Nucl Med 2017; 31:623–628. + + + +
+ + + 36917461 + + 2023 + 03 + 14 + +
+ + 2048-8734 + + + 2023 + Mar + 14 + + + European heart journal. Acute cardiovascular care + Eur Heart J Acute Cardiovasc Care + + Association of accompanying dyspnea with diagnosis and outcome of patients presenting with acute chest discomfort. + zuad026 + 10.1093/ehjacc/zuad026 + + The presence of accompanying dyspnea is routinely assessed and common in patients presenting with acute chest pain/discomfort to the emergency department (ED). We aimed to assess the association of accompanying dyspnea with differential diagnoses, diagnostic work-up and outcome. + We enrolled patients presenting to the ED with chest pain/discomfort. Final diagnoses were adjudicated by independent cardiologists using all information including cardiac imaging. The primary diagnostic endpoint was the final diagnosis. The secondary diagnostic endpoint was the performance of high-sensitivity cardiac troponin (hs-cTn) and the European Society of Cardiology (ESC) 0/1h-algorithms for the diagnosis of myocardial infarction (MI). The prognostic endpoints were cardiovascular and all-cause mortality at two years. + Among 6045 patients, 2892/6045 (48%) had accompanying dyspnea. The prevalence of ACS in patients with versus without dyspnea was comparable (MI 22.4% vs. 21.9%, p = 0.60, unstable angina 8.7% vs. 7.9%, p = 0.29). In contrast, patients with dyspnea more often had cardiac, non-coronary disease (15.3% vs. 10.2%, p < 0.001). Diagnostic accuracy of hs-cTnT/I concentrations was not affected by the presence of dyspnea (area under the curve 0.89-0.91 in both groups) and the safety of the ESC 0/1h-algorithms was maintained with negative predictive values >99.4%. Accompanying dyspnea was an independent predictor for cardiovascular and all-cause death at two years (Hazard Ratio [HR] 1.813 [95%CI, 1.453-2.261, p < 0.01]). + Accompanying dyspnea was not associated with a higher prevalence of ACS but with cardiac, non-coronary disease. While the safety of the diagnostic work-up was not affected, accompanying dyspnea was an independent predictor for cardiovascular and all-cause death. + © The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. + + + + Boeddinghaus + Jasper + J + 0000-0003-4404-4956 + + Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland. + + + GREAT network, Rome, Italy. + + + BHF Centre for Cardiovascular Science, University of Edinburgh, Scotland, United Kingdom. + + + + Nestelberger + Thomas + T + 0000-0003-2173-5738 + + Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland. + + + GREAT network, Rome, Italy. + + + + Koechlin + Luca + L + 0000-0002-2929-8600 + + Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland. + + + GREAT network, Rome, Italy. + + + Department of Cardiac Surgery, University Hospital Basel, University of Basel, Switzerland. + + + + Lopez-Ayala + Pedro + P + 0000-0002-7787-0640 + + Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland. + + + GREAT network, Rome, Italy. + + + + Wussler + Desiree + D + 0000-0002-1793-5297 + + Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland. + + + GREAT network, Rome, Italy. + + + Division of Internal Medicine, University Hospital Basel, University of Basel, Switzerland. + + + + Mais + Maximilian + M + + Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland. + + + + Zwimpfer + Luca + L + 0000-0003-3269-5786 + + Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland. + + + + Zimmermann + Tobias + T + 0000-0002-6862-5205 + + Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland. + + + GREAT network, Rome, Italy. + + + Department of Intensive Care Medicine, University Hospital Basel, University of Basel, Basel, Switzerland. + + + + Wildi + Karin + K + + Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland. + + + GREAT network, Rome, Italy. + + + Critical Care Research Group, the Prince Charles Hospital, Brisbane and the University of Queensland, Brisbane, Australia. + + + + Rubini Giménez + Maria + M + 0000-0003-2384-8250 + + Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland. + + + GREAT network, Rome, Italy. + + + Leipzig Heart Center, Leipzig, Germany. + + + + Strebel + Ivo + I + + Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland. + + + GREAT network, Rome, Italy. + + + + Miró + Òscar + Ò + + GREAT network, Rome, Italy. + + + Emergency Department, Hospital Clinic, Barcelona, Catalonia, Spain. + + + + Martin-Sanchez + F Javier + FJ + + GREAT network, Rome, Italy. + + + Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain. + + + + Parenica + Jiri + J + + Department of Cardiology, University Hospital Brno, Brno, Czech Republic and Medical Faculty, Masaryk University, Brno, Czech Republic. + + + + Keller + Dagmar I + DI + + Emergency Department, University Hospital Zurich, Zurich, Switzerland. + + + + Gualandro + Danielle M + DM + + Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland. + + + GREAT network, Rome, Italy. + + + + Nickel + Christian H + CH + + Emergency Department, University Hospital Basel, University of Basel, Switzerland. + + + + Bingisser + Roland + R + + Emergency Department, University Hospital Basel, University of Basel, Switzerland. + + + + Christ + Michael + M + + Emergency Department, Kantonsspital Luzern, Switzerland. + + + + Mueller + Christian + C + 0000-0002-1120-6405 + + Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland. + + + GREAT network, Rome, Italy. + + + + APACE investigators + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + England + Eur Heart J Acute Cardiovasc Care + 101591369 + 2048-8726 + + IM + + 0/1h-algorithm + Dyspnea + diagnosis of MI + high-sensitivity cardiac troponin + + + + Meier + Mario + M + + + Twerenbold + Raphael + R + + + Puelacher + Christian + C + + + Glarner + Noemi + N + + + Okamura + Bernhard + B + + + Sanchez + Ana Yufera + AY + + + de Lavallaz + Jeanne du Fay + JDF + + + Potlukova + Eliska + E + + + Freese + Michael + M + + + Rentsch + Katharina + K + + + Buser + Andreas + A + + + López + Beatriz + B + + + Martinez-Nadal + Gemma + G + + + Adrada + Esther Rodriguez + ER + + + von Eckardstein + Arnold + A + + + Morawiec + Beata + B + + + Kawecki + Damian + D + + + Muzyk + Piotr + P + + + Bürgler + Franz + F + + + Geigy + Nicolas + N + + +
+ + + + 2022 + 11 + 13 + + + 2022 + 02 + 27 + + + 2023 + 03 + 10 + + + 2023 + 3 + 14 + 12 + 32 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917461 + 7077443 + 10.1093/ehjacc/zuad026 + + +
+ + + 36917452 + + 2023 + 03 + 14 + +
+ + 1715-6580 + + 18 + 3 + + 2023 + Feb + + + Healthcare policy = Politiques de sante + Healthc Policy + + Nursing Home Residents' Use of Radiography in New Brunswick: A Case for Mobile Radiography? + + 31-46 + + hcpol.2023.27036 + 10.12927/hcpol.2023.27036 + + Identifying ways to eliminate unnecessary transfer of nursing home (NH) residents to hospitals provides an opportunity to improve outcomes and use scarce healthcare resources more efficiently. This study's goal was to better understand where NH residents access X-ray (XR) and computed tomography (CT) scans and to determine if there was a case for mobile radiography policies in New Brunswick. + A retrospective analysis of all the visits to the emergency department (ED) and outpatient imaging departments in two hospitals in Saint John, New Brunswick, in 2020, that involved XR or CT investigations was conducted. + There were 521 visits by 311 unique NH residents and 920 investigations (688 XR and 232 CT scans). Most investigations were ordered in the ED (696 of 920; 75.6%; confidence interval: 72.8-78.3%). Of the NH residents who visited the ED and received either an XR or a CT scan, 33.2% received only XR imaging and were discharged back to the NH after a mean ED stay of 5.15 hours. + The pattern of NH residents' use of the ED for their imaging needs supports the creation of mobile XR policies to deliver more safe and efficient care in a Canadian medium population urban centre. + Copyright © 2022 Longwoods Publishing. + + + + Plant + Eric + E + + Candidate, Dalhousie University Medicine, Saint John, NB, Primary Care Paramedic, Ambulance New Brunswick. + + + + Mccloskey + Rose + R + + Professor, Department of Nursing and Health Sciences, University of New Brunswick, Saint John, NB. + + + + Shamputa + Isdore Chola + IC + + Associate Professor, Department of Nursing and Health Sciences, University of New Brunswick, Saint John, NB. + + + + Chandra + Kavish + K + + Assistant Professor, Department of Emergency Medicine, Saint John Regional Hospital, Dalhousie University, Director of Research, Department Emergency Medicine, Saint John Regional Hospital, Saint John, NB. + + + + Atkinson + Paul + P + + Professor, Department of Emergency Medicine, Saint John Regional Hospital, Dalhousie University, Head, Department of Emergency Medicine, Horizon Health Network, Saint John, NB. + + + + Fraser + Jacqueline + J + + Emergency Department Research Coordinator, Saint John Regional Hospital, Saint John, NB, Assistant Managing Editor, Canadian Journal of Emergency Medicine. + + + + Pishe + Tushar + T + + Provincial Medical Director, Ambulance and Transport Services, Department of Health, New Brunswick, Assistant Professor, Department of Emergency Medicine, Saint John Regional Hospital, Dalhousie University, Saint John, NB. + + + + Price + Patrick + P + + Researcher, Dalhousie University Medicine, Saint John, NB. + + + + eng + + Journal Article + +
+ + Canada + Healthc Policy + 101280107 + 1715-6572 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 23 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + ppublish + + 36917452 + hcpol.2023.27036 + 10.12927/hcpol.2023.27036 + + +
+ + + 36917450 + + 2023 + 03 + 14 + +
+ + 1715-6580 + + 18 + 3 + + 2023 + Feb + + + Healthcare policy = Politiques de sante + Healthc Policy + + Multinational Pharmaceutical Companies Shortchange Canada in Research and Development Investments: Is It Time to Pursue Other Options? + + 17-24 + + hcpol.2023.27038 + 10.12927/hcpol.2023.27038 + + In 1987, the government passed legislation to protect brand-name pharmaceutical firms against competition from generic drug brands in exchange for economic investment in Canadian pharmaceutical research and development (R&D). Since 2002, brand-name pharmaceutical companies' R&D investments have fallen short of their commitment, while Canadians now pay the fourth highest drug prices of all the Organisation for Economic Co-operation and Development member countries. In this article, we examine the degree to which brand-name pharmaceutical companies have fallen short of their promises, discuss whether a patent policy is the best strategy to secure Canadian pharmaceutical R&D funding and propose practical alternatives to this arrangement. + Copyright © 2022 Longwoods Publishing. + + + + Lee + Shoo K + SK + + Professor Emeritus, University of Toronto, Honorary Staff Physician, Mount Sinai Hospital, Toronto, ON. + + + + Mahl + Sukhy K + SK + + Assistant Director, MiCare Research Centre, Mount Sinai Hospital, Toronto, ON. + + + + Green + Jessica J + JJ + + Writer, MiCare Research Centre, Mount Sinai Hospital, Toronto, ON. + + + + Lexchin + Joel + J + + Professor Emeritus, School of Health Policy and Management, York University, Toronto, ON. + + + + eng + + Journal Article + +
+ + Canada + Healthc Policy + 101280107 + 1715-6572 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 23 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + ppublish + + 36917450 + hcpol.2023.27038 + 10.12927/hcpol.2023.27038 + + +
+ + + 36917455 + + 2023 + 03 + 14 + +
+ + 1715-6580 + + 18 + 3 + + 2023 + Feb + + + Healthcare policy = Politiques de sante + Healthc Policy + + Dentist Disciplinary Action: What Do Dentists Get in Trouble for? + + 72-83 + + hcpol.2023.27033 + 10.12927/hcpol.2023.27033 + + This study aims to determine the reasons for disciplinary action, the consequences and any associations with demographic factors for Canadian dentists. + Publicly available regulatory body disciplinary action cases from 10 Canadian provinces were coded. Demographic factors were also coded. + There were 344 dentist cases from five provinces between January 2010 and December 2020. The rate of disciplinary action was low (1.38 cases/1,000 practitioners/year). Clinical incompetence was the most common category of disciplinary action, followed by professional misconduct and dishonest business practices. Male dentists were overrepresented in the disciplinary action cases compared to the rest of the workforce. + This study is the first, to our knowledge, to describe the outcomes of regulatory body disciplinary action for Canadian dentists. + Copyright © 2022 Longwoods Publishing. + + + + Foong-Reichert + Ai-Leng + AL + + School of Pharmacy, University of Waterloo, Kitchener, ON. + + + + Houle + Sherilyn K D + SKD + + Assistant Professor, School of Pharmacy, University of Waterloo, Kitchener, ON. + + + + Austin + Zubin + Z + + Professor, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON. + + + + Edwards + David J + DJ + + Professor, School of Pharmacy, University of Waterloo, Kitchener, ON. + + + + Grindrod + Kelly A + KA + + Associate Professor, School of Pharmacy, University of Waterloo, Kitchener, ON, Professor in Pharmacy Innovation, Ontario College of Pharmacists, Toronto, ON. + + + + eng + + Journal Article + +
+ + Canada + Healthc Policy + 101280107 + 1715-6572 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 23 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + ppublish + + 36917455 + hcpol.2023.27033 + 10.12927/hcpol.2023.27033 + + +
+ + + 36917460 + + 2023 + 03 + 14 + +
+ + 0332-3102 + + 115 + No.9 + + 2022 + Oct + 20 + + + Irish medical journal + Ir Med J + + Tele-rehabilitation: redefining stroke early supported discharge during the COVID-19. + + 3 + + + + + + + Condon + M + M + + + Barrett + A + A + + + Pope + L + L + + + Goulding + M + M + + + Healy + L + L + + + O'Caoimh + R + R + + + Hartigan + I + I + + + eng + + Journal Article + + + 2022 + 10 + 20 + +
+ + Ireland + Ir Med J + 0430275 + 0332-3102 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 27 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917460 + + +
+ + + 36917453 + + 2023 + 03 + 14 + +
+ + 1715-6580 + + 18 + 3 + + 2023 + Feb + + + Healthcare policy = Politiques de sante + Healthc Policy + + How Engaged in Legal Planning for Incapacity and Death Are Canadians? A Mixed-Methods Survey. + + 47-59 + + hcpol.2023.27035 + 10.12927/hcpol.2023.27035 + + This study aimed to measure the level of involvement of Canadians in preparing for incapacity and death and to explore facilitators and barriers. + The authors used an online survey based on the social cognitive theory and the Stages of Change model. + One-hundred and forty-eight participants took part. The main facilitators were avoiding burdening others and reducing conflicts. Some respondents thought legal planning did not apply to young and healthy people. Some did not trust lawyers. + The authors suggest that more people would trust lawyers if they knew the limits of legal documents and if they worked with medical experts. + Copyright © 2022 Longwoods Publishing. + + + + Plaisance + Ariane + A + + Post-Doctoral Fellow, Department of Health Sciences, University of Quebec at Rimouski, Lévis, QC. + + + + Stilson + Jessie + J + + Communication Officer, Dhillon School of Business, University of Lethbridge, Lethbridge, AB. + + + + Benadiba + Aurore + A + + Professor, Faculty of Law, Laval University, Quebec City, QC. + + + + Heyland + Daren K + DK + + Professor, Department of Critical Care Medicine, Queen's University, Kingston, ON. + + + + eng + + Journal Article + +
+ + Canada + Healthc Policy + 101280107 + 1715-6572 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 23 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + ppublish + + 36917453 + hcpol.2023.27035 + 10.12927/hcpol.2023.27035 + + +
+ + + 36917458 + + 2023 + 03 + 14 + +
+ + 1520-5207 + + + 2023 + Mar + 14 + + + The journal of physical chemistry. B + J Phys Chem B + + QCM-D Investigations on Cholesterol-DNA Tethering of Liposomes to Microbubbles for Therapy. + 10.1021/acs.jpcb.2c07256 + + Lipid-shelled microbubbles (MBs) offer potential as theranostic agents, capable of providing both contrast enhancement in ultrasound imaging as well as a route for triggered drug release and improved localized drug delivery. A common motif in the design of such therapeutic vehicles is the attachment of the drug carrier, often in the form of liposomes, to the microbubble. Traditionally, such attachments have been based around biotin-streptavidin and maleimide-PDP chemistries. Comparatively, the use of DNA-lipid tethers offers potential advantage. First, their specificity permits the construction of more complex architectures that might include bespoke combinations of different drug-loaded liposomes and/or targeting groups, such as affimers or antibodies. Second, the use of dual-lipid tether strategies should increase the strength of the individual tethers tethering the liposomes to the bubbles. The ability of cholesterol-DNA (cDNA) tethers for conjugation of liposomes to supported lipid bilayers has previously been demonstrated. For in vivo applications, bubbles and liposomes often contain a proportion of polyethylene glycol (PEG) to promote stealth-like properties and increase lifetimes. However, the associated steric effects may hinder tethering of the drug payload. We show that while the presence of PEG reduced the tethering affinity, cDNA can still be used for the attachment of liposomes to a supported lipid bilayer (SLB) as measured via QCM-D. Importantly, we show, for the first time, that QCM-D can be used to study the tethering of microbubbles to SLBs using cDNA, signified by a decrease in the magnitude of the frequency shift compared to liposomes alone due to the reduced density of the MBs. We then replicate this tethering interaction in the bulk and observe attachment of liposomes to the shell of a central MB and hence formation of a model therapeutic microbubble. + + + + Armistead + Fern J + FJ + + Molecular and Nanoscale Physics Group, School of Physics and Astronomy, University of Leeds, Leeds LS2 9JT, United Kingdom. + + + + Batchelor + Damien V B + DVB + 0000-0001-6489-9578 + + Molecular and Nanoscale Physics Group, School of Physics and Astronomy, University of Leeds, Leeds LS2 9JT, United Kingdom. + + + + Johnson + Benjamin R G + BRG + + Molecular and Nanoscale Physics Group, School of Physics and Astronomy, University of Leeds, Leeds LS2 9JT, United Kingdom. + + + + Evans + Stephen D + SD + 0000-0001-8342-5335 + + Molecular and Nanoscale Physics Group, School of Physics and Astronomy, University of Leeds, Leeds LS2 9JT, United Kingdom. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + J Phys Chem B + 101157530 + 1520-5207 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 23 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917458 + 10.1021/acs.jpcb.2c07256 + + +
+ + + 36917451 + + 2023 + 03 + 14 + +
+ + 1715-6580 + + 18 + 3 + + 2023 + Feb + + + Healthcare policy = Politiques de sante + Healthc Policy + + Commentary: Reconsidering Pharmaceutical Research and Development Investments. + + 25-30 + + hcpol.2023.27037 + 10.12927/hcpol.2023.27037 + + Following Lee and colleagues' (2023) article explaining how Canadians are being shortchanged by drug companies when it comes to investments in research and development (R&D), this rejoinder adds context and appends two other very problematic elements in the debate between wishful narratives over the industry's contribution in R&D and actual numbers. First, even the current stricter definition of R&D investment might simply be too large considering that elements such as seeding trials - a well-known marketing device - can be accounted for as R&D expenditures. Second, this rejoinder identifies how Statistics Canada acted in concert with Innovative Medicines Canada to reinforce the industry's preferred narratives around R&D expenditures. This situation puts into question the trustworthiness of Canada's statistical agency. + Copyright © 2022 Longwoods Publishing. + + + + Gagnon + Marc-André + MA + + Associate Professor, School of Public Policy and Administration, Carleton University, Ottawa, ON. + + + + eng + + Journal Article + +
+ + Canada + Healthc Policy + 101280107 + 1715-6572 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 23 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + ppublish + + 36917451 + hcpol.2023.27037 + 10.12927/hcpol.2023.27037 + + +
+ + + 36917454 + + 2023 + 03 + 14 + +
+ + 1715-6580 + + 18 + 3 + + 2023 + Feb + + + Healthcare policy = Politiques de sante + Healthc Policy + + Pharmacist Disciplinary Action: What Do Pharmacists Get in Trouble for? + + 60-71 + + hcpol.2023.27034 + 10.12927/hcpol.2023.27034 + + This study aims to determine the reasons for disciplinary action and resultant consequences for Canadian pharmacists and any associations with demographic factors. + Regulatory body disciplinary action cases from 10 Canadian provinces were coded. Demographic information was coded. + There were 665 pharmacist cases from nine provinces between January 2010 and December 2020. The rate of disciplinary action was low (1.37 cases/1,000 practitioners/year). Professional misconduct was the most common category of violation. Male pharmacists were overrepresented in disciplinary action cases. Most cases involved community pharmacists. + This study is the first, to our knowledge, in Canada to analyze the demographic factors of pharmacists subjected to disciplinary action. It updates a previous review of pharmacist disciplinary action (Foong et al. 2018). + Copyright © 2022 Longwoods Publishing. + + + + Foong-Reichert + Ai-Leng + AL + + School of Pharmacy, University of Waterloo, Kitchener, ON. + + + + Grindrod + Kelly A + KA + + Associate Professor, School of Pharmacy, University of Waterloo, Kitchener, ON, Professor in Pharmacy Innovation, Ontario College of Pharmacists, Toronto, ON. + + + + Edwards + David J + DJ + + Professor, School of Pharmacy, University of Waterloo, Kitchener, ON. + + + + Austin + Zubin + Z + + Professor, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON. + + + + Houle + Sherilyn K D + SKD + + Assistant Professor, School of Pharmacy, University of Waterloo, Kitchener, ON. + + + + eng + + Journal Article + +
+ + Canada + Healthc Policy + 101280107 + 1715-6572 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 23 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + ppublish + + 36917454 + hcpol.2023.27034 + 10.12927/hcpol.2023.27034 + + +
+ + + 36917466 + + 2023 + 03 + 14 + +
+ + 0332-3102 + + 115 + 1 + + 2022 + Oct + 20 + + + Irish medical journal + Ir Med J + + Supporting Medical Students Towards Future Careers in General Practice: A Quantitative Study of Irish Medical Schools. + + 10 + + + + Murphy + A W + AW + + + Moran + D + D + + + Smith + S M + SM + + + Wallace + E + E + + + Glynn + L G + LG + + + Hanley + K + K + + + Kelly + M E + ME + + + eng + + Journal Article + + + 2022 + 10 + 20 + +
+ + Ireland + Ir Med J + 0430275 + 0332-3102 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 32 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917466 + + +
+ + + 36917468 + + 2023 + 03 + 14 + +
+ + 1520-5215 + + + 2023 + Mar + 14 + + + The journal of physical chemistry. A + J Phys Chem A + + Time-Dependent Density-Functional Theory for Determining the Electron-Capture Cross Section for Protons Impacting on Atoms and Molecules. + 10.1021/acs.jpca.2c08213 + + The use of the Time-Dependent Density-Functional Theory (TDDFT) has increased in the atomic collision field. Calculating the electron-capture cross section (ECCS) for protons is an important question in hadrontherapy and plasma physics, among other areas. In previous studies, it was shown that the approach based on the Local Density Approximation (LDA) fails in the 1-50 keV region, requiring the use of the Optimized Effective Potential (OEP) method. In this work, the ECCS values for 1-50 keV protons impacting on isolated hydrogen, carbon, nitrogen, oxygen, and nitrogenous atoms were determined using the TDDFT. It is shown that adding the Self Interaction Correction to the LDA (LDA-Sic) allows obtaining results close to those provided by the OEP and experiments, with the advantage that the LDA-Sic consumes less computational time. In addition, it was demonstrated that it is imperative to include the spin correction for the specific helium and oxygen cases, in order to get good results for the ECCS using the TDDFT. Theoretical results obtained in this work show excellent agreement with experimental values. + + + + de Faria + Jhaison C + JC + 0000-0003-0544-4498 + + Instituto de Física Gleb Wataghin, Universidade Estadual de Campinas, Campinas 13083-859, SP, Brazil. + + + + Santiago + João + J + + Instituto de Física Gleb Wataghin, Universidade Estadual de Campinas, Campinas 13083-859, SP, Brazil. + + + + Francis + Ziad + Z + + Faculty of Sciences, Campus of Science and Technologies, Saint Joseph University of Beirut, 22411 Mansourieh, Lebanon. + + + + Bernal + Mario A + MA + 0000-0002-8305-5298 + + Instituto de Física Gleb Wataghin, Universidade Estadual de Campinas, Campinas 13083-859, SP, Brazil. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + J Phys Chem A + 9890903 + 1089-5639 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 32 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917468 + 10.1021/acs.jpca.2c08213 + + +
+ + + 36917470 + + 2023 + 03 + 14 + +
+ + 1520-6882 + + + 2023 + Mar + 14 + + + Analytical chemistry + Anal Chem + + Direct Measurement of Nucleoside Ribohydrolase Enzyme Activities in Trichomonas vaginalis Cells Using 19F and 13C-Edited 1H NMR Spectroscopy. + 10.1021/acs.analchem.2c05330 + + Trichomoniasis is the most common nonviral sexually transmitted infection, affecting an estimated 275 million people worldwide. The causative agent is the parasitic protozoan Trichomonas vaginalis. Although the disease itself is typically mild, individuals with trichomonal infections have a higher susceptibility to more serious conditions. The emergence of parasite strains resistant to current therapies necessitates the need for novel treatment strategies. Since T. vaginalis is an obligate parasite that requires nucleoside salvage pathways, essential nucleoside ribohydrolase enzymes are promising new drug targets. Fragment screening and X-ray crystallography have enabled structure-guided design of inhibitors for two of these enyzmes. Linkage of enzymatic and antiprotozoal activity would be a transformative step toward designing novel, mechanism-based therapeutic agents. While a correlation with inhibition of purified enzyme would be mechanistically suggestive, a correlation with inhibition of in-cell enzyme activity would definitively establish this linkage. To demonstrate this linkage, we have translated our NMR-based activity assays that measure the activity of purified enzymes for use in T. vaginalis cells. The 19F NMR-based activity assay for the pyrimidine-specific enzyme translated directly to in-cell assays. However, the 1H NMR-based activity assay for the purine-specific enzyme required a switch from adenosine to guanosine substrate and the use of 13C-editing to resolve the substrate 1H signals from cell and growth media background signals. The in-cell NMR assays are robust and have been demonstrated to provide inhibition data on test compounds. The results described here represent the first direct measurement of enzyme activity in protozoan parasite cells. + + + + Stockman + Brian J + BJ + 0000-0002-8520-9588 + + Department of Chemistry, Adelphi University, 1 South Avenue, Garden City, New York 11530, United States. + + + + Ventura + Carlos A + CA + + Department of Chemistry, Adelphi University, 1 South Avenue, Garden City, New York 11530, United States. + + + + Deykina + Valerie S + VS + + Department of Chemistry, Adelphi University, 1 South Avenue, Garden City, New York 11530, United States. + + + + Khayan Lontscharitsch + Nickolas + N + + Department of Chemistry, Adelphi University, 1 South Avenue, Garden City, New York 11530, United States. + + + + Saljanin + Edina + E + + Department of Chemistry, Adelphi University, 1 South Avenue, Garden City, New York 11530, United States. + + + + Gil + Ari + A + + Department of Chemistry, Adelphi University, 1 South Avenue, Garden City, New York 11530, United States. + + + + Canestrari + Madison + M + + Department of Chemistry, Adelphi University, 1 South Avenue, Garden City, New York 11530, United States. + + + + Mahmood + Maham + M + + Department of Chemistry, Adelphi University, 1 South Avenue, Garden City, New York 11530, United States. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Anal Chem + 0370536 + 0003-2700 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 32 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917470 + 10.1021/acs.analchem.2c05330 + + +
+ + + 36917479 + + 2023 + 03 + 14 + +
+ + 1534-7796 + + + 2023 + Feb + 27 + + + Psychosomatic medicine + Psychosom Med + + Depression treatment initiation among patients with versus without chronic pain. + 10.1097/PSY.0000000000001184 + + The purpose of this study was to examine the extent to which the presence of chronic non-cancer pain (CNCP) impacts the likelihood that patients with diagnoses of depression will initiate depression treatment compared to those without CNCP. + We performed a retrospective cohort study of Kaiser Permanente of Georgia members >18 years who received a diagnosis of depression. Demographics and medical history were extracted from the electronic health record database. Members were further classified by the presence or absence of a CNCP diagnosis. Outcomes of interest were treated as time dependent and included (1) time to fulfillment of a new anti-depressant medication and (2) time to a follow-up mental health encounter. Outcomes were compared between members with and without a CNCP diagnosis using Kaplan-Meier survival curves and Cox Proportional hazard regression models. + During the study period, 22,996 members met inclusion and 27.4% had a diagnosis of CNCP. In the matched sample, there was no difference in the time to a new anti-depressant fill among members with and without CNCP (HR = 0.96; 95%CI: 0.90, 1.02; p = 0.18). In contrast, members with CNCP were significantly less likely to have a new mental health encounter following diagnosis (HR: 0.87; 95%CI: 0.81, 0.94; p < 0.001). + Patients with CNCP were significantly less likely to have a new mental health encounter following a depression diagnosis compared to patients without CNCP. Additional outreach and consideration may be needed to improve initiation of depression treatment for newly diagnosed patients with comorbid depression and CNCP. + Copyright © 2023 by the American Psychosomatic Society. + + + + Owen-Smith + Ashli + A + + + McDonald + Bennett + B + + Kaiser Permanente Georgia, Center for Research and Evaluation. + + + + Sesay + Musu M + MM + + Kaiser Permanente Georgia, Center for Research and Evaluation. + + + + Simon + Greg + G + + Kaiser Permanente Washington, Health Research Institute. + + + + McCracken + Courtney + C + + Kaiser Permanente Georgia, Center for Research and Evaluation. + + + + eng + + Journal Article + + + 2023 + 02 + 27 + +
+ + United States + Psychosom Med + 0376505 + 0033-3174 + + IM + Conflicts of Interest and Source of Funding: The authors declare that they have no competing interests. This project was supported by Award Number U19MH092201 from the National Institute of Mental Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Mental Health or the National Institutes of Health. +
+ + + + 2023 + 3 + 14 + 12 + 42 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917479 + 10.1097/PSY.0000000000001184 + 00006842-990000000-00099 + + +
+ + + 36917465 + + 2023 + 03 + 14 + +
+ + 1936-7163 + + 0 + 0 + + 2023 + Mar + 14 + + + Quintessence international (Berlin, Germany : 1985) + Quintessence Int + + The potential impact of delivery mode and breastfeeding on oral Candida species carriage in a population of young adults. + + 0 + + 10.3290/j.qi.b3957701 + + In early life, children are exposed to microorganisms from maternal and environmental sources, which influence the development of their microbiome throughout life. Several studies have demonstrated the influence of the delivery mode and breastfeeding on the oral microbiome of children, mostly regarding bacterial colonization. However, their influence on the oral fungal carriage is still underexplored. This study aimed to assess the association of the delivery and feeding mode with the oral carriage of yeasts in adulthood. + Fungal oral carriage was evaluated by collecting unstimulated saliva in 185 healthy dental students (mean age of 21.51±1.55 years old; 81.6% females). Yeast identification was performed by culture in ChromAgar Candida medium and sequencing of the 18S genes and ITS regions for determination of the species. Demographic and clinical data of each participant was recorded through questionnaires and oral examinations were performed in a subgroup of participants (n=49). + Candida species were isolated in 37.5% of all participants. The prevalence of yeasts in the oral cavity was significantly higher in those who were born by vaginal delivery compared to those born by caesarean-section (p=0.035), whereas no statistically significant differences were observed regarding breastfeeding (p=0.398). Low salivary flow rate and frequency of dental visits also were associated with oral yeast carriage (p<0.05). + Our study suggests a possible impact of the type of delivery on fungal colonization, which is sustained throughout life due to oral health-related factors. + + + + Azevedo + Maria João + MJ + + + Campos + Paula + P + + + Araujo + Ricardo + R + + + Magalhães + Inês + I + + + Pereira + Maria de Lurdes + ML + + + Azevedo + Alvaro + A + + + Zaura + Egija + E + + + Ramalho + Carla + C + + + Sampaio-Maia + Benedita + B + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Quintessence Int + 0342677 + 0033-6572 + + + Candida + breastfeeding + mode of delivery + oral carriage + saliva + yeasts + +
+ + + + 2023 + 3 + 14 + 12 + 32 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917465 + 3957701 + 10.3290/j.qi.b3957701 + + +
+ + + 36917469 + + 2023 + 03 + 14 + +
+ + 2063-5303 + + + 2023 + Mar + 14 + + + Journal of behavioral addictions + J Behav Addict + + The concept of recovery in gaming disorder: A scoping review. + 10.1556/2006.2023.00002 + + Recovery from mental health and behavioral disorders is classically defined as a reduction in symptoms. More recent definitions see it as a process in which individuals improve their health, wellness and other life domains. The inclusion of gaming disorder (GD) in the 11th International Classification of Diseases in 2019 prompted growing interest in GD. However, relatively little is known about recovery from GD, and there is scant literature describing or assessing its course. + This scoping review was designed to explore the state of the art on recovery from GD (e.g., terminology and measures used to assess recovery, main topics in studies about recovery from GD). + PubMed, Web of Science, and Scopus databases were searched and critically reviewed according to PRISMA guidelines. We included empirical studies in English covering individuals across all age groups who met the diagnostic criteria of GD/internet gaming disorder (IGD) according to valid scales that relate to recovery or any change, and were published before February 2022. + A total of 47 out of 966 studies met the inclusion criteria. Recovery as a concept is not explicitly mentioned in GD studies. Rather, changes in subjects' disorders are described in terms of decreases/reductions in symptom severity, or improvement/increases. These changes are primarily measured by scales that evaluate symptom reduction and/or improvement in GD and other psychopathologies. + The concept of recovery is included in the GD field but is not clearly mentioned or used. Therapists and researchers should aim to promote and integrate the notion of recovery in GD. + + + + Gavriel-Fried + Belle + B + + 1The Bob Shapell School of Social Work, Tel Aviv University, Israel. + + + + Serry + Meytal + M + 0000-0003-2820-2205 + + 1The Bob Shapell School of Social Work, Tel Aviv University, Israel. + + + + Katz + Dana + D + 0000-0002-7132-258X + + 2Institute of Psychology, ELTE Eötvös Loránd University, Budapest, Hungary. + + + + Hidvégi + Dorottya + D + + 2Institute of Psychology, ELTE Eötvös Loránd University, Budapest, Hungary. + + + + Demetrovics + Zsolt + Z + + 2Institute of Psychology, ELTE Eötvös Loránd University, Budapest, Hungary. + + + 3Centre of Excellence in Responsible Gaming, University of Gibraltar, Gibraltar, Gibraltar. + + + + Király + Orsolya + O + 0000-0001-9981-4212 + + 2Institute of Psychology, ELTE Eötvös Loránd University, Budapest, Hungary. + + + + eng + + Journal Article + Review + + + 2023 + 03 + 14 + +
+ + Hungary + J Behav Addict + 101602037 + 2062-5871 + + IM + + gaming disorder + improvement + interventions + recovery + scoping review + treatment + +
+ + + + 2022 + 08 + 26 + + + 2022 + 12 + 05 + + + 2023 + 02 + 03 + + + 2023 + 3 + 14 + 12 + 32 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917469 + 10.1556/2006.2023.00002 + + +
+ + + 36917463 + + 2023 + 03 + 14 + +
+ + 1936-7163 + + 0 + 0 + + 2023 + Mar + 14 + + + Quintessence international (Berlin, Germany : 1985) + Quintessence Int + + Photodynamic therapy as an adjunctive treatment for grade C periodontitis in molar teeth: a preliminary trial. + + 0 + + 10.3290/j.qi.b3957661 + + The present study aimed to evaluate the local effect of antimicrobial photodynamic therapy (aPDT) as adjunctive treatment for grade C periodontitis in molars teeth. + Thirty-eight molar teeth from 11 patients were included in this split-mouth randomized clinical trial. The teeth were randomly divided into two groups (n = 19 each) that were submitted to conventional scaling and root planing in addition to aPDT (test group) and to scaling and root planing in addition to aPDT simulation (control group). The following periodontal parameters were obtained prior to treatment (baseline) and at 3 months after the intervention: bleeding on probing, probing depth, gingival recession, clinical attachment level, and furcation level. A 5% significance level was adopted in the statistical analysis. + Both groups exhibited improvement in the clinical parameters (p < 0.001). However, the reductions in bleeding on probing and probing depth were greater in the test group (p < 0.001). There were no significant differences in the other clinical parameters between groups (p ≥ 0.13). + Molar teeth treated with aPDT and scaling and root planing showed superior clinical improvement compared to those submitted only to scaling and root planning. Antimicrobial PDT may be used as adjunctive treatment for grade C periodontitis affecting molar teeth since it seems to improve the clinical response to conventional debridement. + + + + Coelho + Tayane da Rocha Costa + TDRC + + + Pinto Filho + Jorge Moreira + JM + + + Figueiredo + Livia Silva + LS + + + Caponi + Ribeiro + R + + + Soares + Jessica da Mota + JDM + + + Dos Santos + Jean Nunes + JN + + + Cury + Patricia Ramos + PR + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Quintessence Int + 0342677 + 0033-6572 + + + Aggressive Periodontitis + Periodontal Diseases + Photochemotherapy + Randomized Controlled Trial + +
+ + + + 2023 + 3 + 14 + 12 + 32 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917463 + 3957661 + 10.3290/j.qi.b3957661 + + +
+ + + 36917478 + + 2023 + 03 + 14 + +
+ + 1552-9924 + + 131 + 3 + + 2023 + Mar + + + Environmental health perspectives + Environ Health Perspect + + Residential Proximity to Metal-Containing Superfund Sites and Their Potential as a Source of Disparities in Metal Exposure among U.S. Women. + + 37701 + + 10.1289/EHP11045 + + + Trottier + Brittany A + BA + + Hazardous Substances Research Branch, Division of Extramural Research and Training, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA. + + + Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. + + + + Niehoff + Nicole M + NM + + Epidemiology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA. + + + + Keil + Alexander P + AP + + Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. + + + Epidemiology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA. + + + + Jones + Rena R + RR + + Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA. + + + + Levine + Keith E + KE + + RTI International, Research Triangle Park, North Carolina, USA. + + + + MacNell + Nathaniel S + NS + + Social & Scientific Systems, Inc., Durham, North Carolina, USA. + + + + White + Alexandra J + AJ + 0000-0003-2455-2945 + + Epidemiology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Environ Health Perspect + 0330411 + 0091-6765 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 42 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + ppublish + + 36917478 + 10.1289/EHP11045 + + +
+ + + 36917467 + + 2023 + 03 + 14 + +
+ + 1477-0539 + + + 2023 + Mar + 14 + + + Organic & biomolecular chemistry + Org Biomol Chem + + Synthesis and evaluation of NHC derivatives and 4'-fluorouridine prodrugs. + 10.1039/d3ob00268c + + β-D-N4-Hydroxycytidine (NHC) derivatives with structural modifications at the C4', O4' or C6 position and 4'-fluorouridine prodrugs were synthesized and evaluated for their antiviral activities against respiratory syncytial virus (RSV) or influenza virus (IFV) in vitro. The NHC derivatives were found inactive, but 4'-fluorouridine and its prodrugs had potent anti-RSV and anti-IFV activities. 4'-Fluorouridine was proved to be a nucleoside with poor stability, but the tri-ester prodrugs exhibited enhanced stability, especially tri-isobutyrate ester 1a. This prodrug also showed excellent oral pharmacokinetic properties in rats, with potential to be an oral antiviral candidate. + + + + Xiang + Li + L + + School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, P. R. China. shenjingshan@simm.ac.cn. + + + State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, P. R. China. + + + + Hu + Tianwen + T + + State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, P. R. China. + + + University of Chinese Academy of Sciences, Beijing 100049, P. R. China. + + + + Xue + Haitao + H + + State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, P. R. China. + + + University of Chinese Academy of Sciences, Beijing 100049, P. R. China. + + + + Pan + Wenfang + W + + State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, P. R. China. + + + University of Chinese Academy of Sciences, Beijing 100049, P. R. China. + + + + Xie + Yuanchao + Y + + Lingang Laboratory, Shanghai 200031, P. R. China. xieyuanchao@lglab.ac.cn. + + + + Shen + Jingshan + J + http://orcid.org/0000-0001-9679-9934 + + School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, P. R. China. shenjingshan@simm.ac.cn. + + + State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, P. R. China. + + + University of Chinese Academy of Sciences, Beijing 100049, P. R. China. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + England + Org Biomol Chem + 101154995 + 1477-0520 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 32 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917467 + 10.1039/d3ob00268c + + +
+ + + 36917475 + + 2023 + 03 + 14 + +
+ + 1735-367X + + 20 + 1 + + 2023 + Mar + 14 + + + Iranian journal of immunology : IJI + Iran J Immunol + + Vaccine Adjuvants: Selection Criteria, Mechanism of Action Associated with Immune Responses and Future Directions. + + 1-15 + + 10.22034/iji.2023.94097.2284 + + The most effective method to minimize the prevalence of infectious diseases is vaccination. Vaccines enhance immunity and provide protection against different kinds of infections. Subunit vaccines are safe and less toxic, but due to their lower immunogenicity, they need adjuvants to boost the immune system. Adjuvants are small particles/molecules integrated into a vaccine to enhance the immunogenic feedback of antigens. They play a significant role to enhance the potency and efficiency of vaccines. There are several types of adjuvants with different mechanisms of action; therefore, improved knowledge of their immunogenicity will help develop a new generation of adjuvants. Many trials have been designed using different kinds of vaccine adjuvants to examine their safety and efficacy, but in practice, only a few have entered in animal and human clinical trials. However, for the development of safe and effective vaccines, it is important to have adequate knowledge of the side effects and toxicity of different adjuvants. The current review discussed the adjuvants which are available for producing modern vaccines as well as some new classes of adjuvants in clinical trials. + + + + Habib + Arslan + A + + Laboratory of Molecular Immunology, State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200433, PR China. + + + + Anjum + Khalid Mahmood + KM + + + Iqbal + Riffat + R + + + Jaffar + Ghulam + G + + + Ashraf + Zeeshan + Z + + + Khalid + Malik ShahZaib + MS + + + Taj + Muhammad Usman + MU + + + Yulai + Liang + L + + + Zainab + Syeda Wafa + SW + + + Umair + Muhammad + M + + + Zohaib + Muhammad + M + + + Khalid + Tabinda + T + + + eng + + Journal Article + Review + + + 2023 + 03 + 14 + +
+ + Iran + Iran J Immunol + 101282932 + 1735-1383 + + IM + + Adjuvants + Immune system + Immunogenic feedback + Licensed adjuvants + Vaccine + +
+ + + + 2023 + 3 + 14 + 12 + 37 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917475 + 10.22034/iji.2023.94097.2284 + + +
+ + + 36917474 + + 2023 + 03 + 14 + +
+ + 1460-2156 + + + 2023 + Mar + 14 + + + Brain : a journal of neurology + Brain + + A homozygous POLR1A variant causes leukodystrophy and affects protein homeostasis. + awad086 + 10.1093/brain/awad086 + + RNA polymerase I transcribes ribosomal DNA to produce precursor 47S rRNA. Post-transcriptional processing of this rRNA generates mature 28S, 18S and 5.8S rRNAs, which form the ribosomes, together with 5S rRNA, assembly factors, and ribosomal proteins. We previously reported a homozygous variant in the catalytic subunit of RNA polymerase I, POLR1A, in two brothers with leukodystrophy and progressive course. However, the disease mechanism remained unknown. In this report, we describe another missense variant POLR1A NM_015425.3:c.1925C > A; p.(Thr642Asn) in homozygosity in two unrelated patients. Patient 1 was a 16-year-old male and patient 2 was a 2-year-old female. Both patients manifested neurological deficits, with brain MRIs showing hypomyelinating leukodystrophy, and cerebellar atrophy; and in patient 1 additionally with hypointensity of globi pallidi and small volume of the basal ganglia. Patient 1 had progressive disease course, leading to death at the age of 16.5 years. Extensive in vitro experiments in fibroblasts from patient 1 documented that the mutated POLR1A led to aberrant rRNA processing and degradation, and abnormal nucleolar homeostasis. Proteomics data analyses and further in vitro experiments documented abnormal protein homeostasis, and endoplasmic reticulum stress responses. We confirm that POLR1A biallelic variants cause neurodegenerative disease, expand the knowledge of the clinical phenotype of the disorder, and provide evidence for possible pathological mechanisms leading to POLR1A-related leukodystrophy. + © The Author(s) 2023. Published by Oxford University Press on behalf of the Guarantors of Brain. + + + + Misceo + Doriana + D + 0000-0002-6594-5801 + + Department of Medical Genetics, Oslo University Hospital and University of Oslo, 0450 Oslo, Norway. + + + + Lirussi + Lisa + L + + Department of Clinical Molecular Biology, University of Oslo, 0318 Oslo, Norway. + + + Section of Clinical Molecular Biology (EpiGen), Akershus University Hospital, 1478 Lørenskog, Norway. + + + + Strømme + Petter + P + + Division of Pediatric and Adolescent Medicine, Oslo University Hospital and University of Oslo, 0450 Oslo, Norway. + + + + Sumathipala + Dulika + D + + Department of Medical Genetics, Oslo University Hospital and University of Oslo, 0450 Oslo, Norway. + + + + Guerin + Andrea + A + + Kingston Health Sciences Centre, Queen's Medical School, Kingston, ON K7L 2V7, Canada. + + + + Wolf + Nicole I + NI + 0000-0003-1721-0728 + + Department of Child Neurology, Amsterdam Leukodystrophy Center, Emma Children's Hospital, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, and Amsterdam Neuroscience, 1081 HV Amsterdam, the Netherlands. + + + + Server + Andres + A + + Section of Neuroradiology, Department of Radiology and Nuclear Medicine, Oslo University Hospital, Rikshospitalet, 0424 Oslo, Norway. + + + + Stensland + Maria + M + + Department of Immunology, Oslo University Hospital and Faculty of Medicine, University of Oslo, 0372 Oslo, Norway. + + + + Dalhus + Bjørn + B + + Department for Microbiology, Oslo University Hospital, 0424 Oslo, Norway. + + + Department for Medical Biochemistry, University of Oslo, 0424 Oslo, Norway. + + + + Tolun + Aslıhan + A + + Department of Molecular Biology and Genetics, MOBGAM, Istanbul Technical University, 34469 Istanbul, Turkey. + + + + Kroes + Hester Y + HY + + Department of Genetics, UMC 3584 CX Utrecht, The Netherlands. + + + + Nyman + Tuula A + TA + + Department of Immunology, Oslo University Hospital and Faculty of Medicine, University of Oslo, 0372 Oslo, Norway. + + + + Nilsen + Hilde L + HL + + Department of Clinical Molecular Biology, University of Oslo, 0318 Oslo, Norway. + + + Section of Clinical Molecular Biology (EpiGen), Akershus University Hospital, 1478 Lørenskog, Norway. + + + Department for Microbiology, Oslo University Hospital, 0424 Oslo, Norway. + + + + Frengen + Eirik + E + 0000-0002-8387-2247 + + Department of Medical Genetics, Oslo University Hospital and University of Oslo, 0450 Oslo, Norway. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + England + Brain + 0372537 + 0006-8950 + + IM + + POLR1A + myelin + neurodegeneration + rRNA + ribosome + +
+ + + + 2022 + 03 + 29 + + + 2023 + 02 + 10 + + + 2023 + 02 + 20 + + + 2023 + 3 + 14 + 12 + 33 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917474 + 7077446 + 10.1093/brain/awad086 + + +
+ + + 36917464 + + 2023 + 03 + 14 + +
+ + 1936-7163 + + 0 + 0 + + 2023 + Mar + 14 + + + Quintessence international (Berlin, Germany : 1985) + Quintessence Int + + Screening for diabetes risk using the diabetes risk test and point-of-care hemoglobin A1C values in adults seen in a dental clinic. + + 0 + + 10.3290/j.qi.b3957685 + + To explore the feasibility of screening for type 2 diabetes (T2DM) and the prevalence of adult patients seen in a dental clinic at risk for T2DM based on American Diabetes Association (ADA) diabetes risk test (DRT) scores and Point of Care (POC) Hemoglobin A1C (A1C) values. + A cross-sectional analysis of data from adults 18-89 years old seen in an academic dental clinic between November 2019 and April 2022 without prior history of diabetes. Clinical and demographic data were obtained from electronic health records and odontograms. Frequency distributions, chi-square, and Mann-Whitney U tests were used for data analysis. + Of the 13,519 patients whose data were included, 54.7% (n=7,389) were female. Of those with race and ethnicity data, 53.6% (n=2,871) were white, 40.2% (n=2,153) were African American, and 29.5% (n=1,559) were Hispanic/Latino. Mean ±SD age was 47.0+17.0 years; mean±SD BMI was 28.0+6.1 kg/m2. Thirty-five percent (n=4,774) had DRT scores reflecting T2DM risk. Those at risk were more likely to be older, male, and overweight/obese than those not at risk (P<0.001). Of those at risk who consented to a POC A1C (9.8%, n=470), 40.2% (n=189) had values consistent with dysglycemia (A1C>5.7%); 34.9% (n=164) reflecting prediabetes (A1C= 5.7-6.4%) and 5.3% (n=25) diabetes (A1C>6.5%). + Diabetes screening in a dental clinic identified that over one-third of adults without T2DM were at risk based on DRT scores. Of those who had POC AICs conducted; 40% had dysglycemia. Diabetes screening in an academic dental clinic can help identify patients at risk for T2DM. + + + + Zelig + Rena + R + + + Samavat + Hamed + H + + + Duda + Peter + P + + + Singer + Steven R + SR + + + Feldman + Cecile + C + + + LaSalle + Patricia + P + + + Muhammad + Ellen + E + + + Touger-Decker + Riva + R + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Quintessence Int + 0342677 + 0033-6572 + + + Dental Clinic + Diabetes Mellitus Type 2 + Diabetes Screening + Glycated Hemoglobin + Prediabetic State + +
+ + + + 2023 + 3 + 14 + 12 + 32 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917464 + 3957685 + 10.3290/j.qi.b3957685 + + +
+ + + 36917471 + + 2023 + 03 + 14 + +
+ + 1477-4054 + + + 2023 + Mar + 14 + + + Briefings in bioinformatics + Brief Bioinform + + Benchmarking genome assembly methods on metagenomic sequencing data. + bbad087 + 10.1093/bib/bbad087 + + Metagenome assembly is an efficient approach to reconstruct microbial genomes from metagenomic sequencing data. Although short-read sequencing has been widely used for metagenome assembly, linked- and long-read sequencing have shown their advancements in assembly by providing long-range DNA connectedness. Many metagenome assembly tools were developed to simplify the assembly graphs and resolve the repeats in microbial genomes. However, there remains no comprehensive evaluation of metagenomic sequencing technologies, and there is a lack of practical guidance on selecting the appropriate metagenome assembly tools. This paper presents a comprehensive benchmark of 19 commonly used assembly tools applied to metagenomic sequencing datasets obtained from simulation, mock communities or human gut microbiomes. These datasets were generated using mainstream sequencing platforms, such as Illumina and BGISEQ short-read sequencing, 10x Genomics linked-read sequencing, and PacBio and Oxford Nanopore long-read sequencing. The assembly tools were extensively evaluated against many criteria, which revealed that long-read assemblers generated high contig contiguity but failed to reveal some medium- and high-quality metagenome-assembled genomes (MAGs). Linked-read assemblers obtained the highest number of overall near-complete MAGs from the human gut microbiomes. Hybrid assemblers using both short- and long-read sequencing were promising methods to improve both total assembly length and the number of near-complete MAGs. This paper also discussed the running time and peak memory consumption of these assembly tools and provided practical guidance on selecting them. + © The Author(s) 2023. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com. + + + + Zhang + Zhenmiao + Z + + Department of Computer Science, Hong Kong Baptist University, Kowloon Tong, Hong Kong. + + + + Yang + Chao + C + + Department of Computer Science, Hong Kong Baptist University, Kowloon Tong, Hong Kong. + + + + Veldsman + Werner Pieter + WP + + Department of Computer Science, Hong Kong Baptist University, Kowloon Tong, Hong Kong. + + + + Fang + Xiaodong + X + + BGI Genomics, BGI-Shenzhen, Shenzhen, China. + + + BGI-Shenzhen, Shenzhen, China. + + + State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. + + + + Zhang + Lu + L + + Department of Computer Science, Hong Kong Baptist University, Kowloon Tong, Hong Kong. + + + Institute for Research and Continuing Education, Hong Kong Baptist University, Shenzhen, China. + + + + eng + + + 2019A1515011046 + Applied Basic Research Foundation of Yunnan Province + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + England + Brief Bioinform + 100912837 + 1467-5463 + + IM + + genome assembly tools + linked-read sequencing + long-read sequencing + metagenome-assembled genome + metagenomic sequencing + short-read sequencing + +
+ + + + 2022 + 09 + 28 + + + 2023 + 01 + 09 + + + 2023 + 02 + 15 + + + 2023 + 3 + 14 + 12 + 32 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917471 + 7077274 + 10.1093/bib/bbad087 + + +
+ + + 36917473 + + 2023 + 03 + 14 + +
+ + 1364-548X + + + 2023 + Mar + 14 + + + Chemical communications (Cambridge, England) + Chem Commun (Camb) + + A hypoxia-activated photothermal agent inhibits multiple heat shock proteins for low-temperature photothermal therapy. + 10.1039/d2cc06598c + + A near-infrared (NIR) organic photothermal agent (PTA) to inhibit three types of heat shock proteins (HSPs) was synthesized, which could be activated under hypoxic conditions for low-temperature photothermal therapy (PTT) of cancer. + + + + Zhang + Xinhao + X + + College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan 250014, P. R. China. panwei@sdnu.edu.cn. + + + + Xue + Shan-Shan + SS + http://orcid.org/0000-0001-7093-7825 + + College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan 250014, P. R. China. panwei@sdnu.edu.cn. + + + + Pan + Wei + W + http://orcid.org/0000-0002-2281-8749 + + College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan 250014, P. R. China. panwei@sdnu.edu.cn. + + + + Wang + Kaiye + K + + College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan 250014, P. R. China. panwei@sdnu.edu.cn. + + + + Li + Na + N + http://orcid.org/0000-0002-0392-6672 + + College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan 250014, P. R. China. panwei@sdnu.edu.cn. + + + + Tang + Bo + B + http://orcid.org/0000-0002-8712-7025 + + College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan 250014, P. R. China. panwei@sdnu.edu.cn. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + England + Chem Commun (Camb) + 9610838 + 1359-7345 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 33 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917473 + 10.1039/d2cc06598c + + +
+ + + 36917480 + + 2023 + 03 + 14 + +
+ + 1944-7876 + + 44 + 3 + + 2023 + Mar + + + Foot & ankle international + Foot Ankle Int + + Education Calendar. + + 259 + + 10.1177/10711007231161730 + eng + + Journal Article + +
+ + United States + Foot Ankle Int + 9433869 + 1071-1007 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 42 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + ppublish + + 36917480 + 10.1177/10711007231161730 + + +
+ + + 36917472 + + 2023 + 03 + 14 + +
+ + 1477-4054 + + + 2023 + Mar + 14 + + + Briefings in bioinformatics + Brief Bioinform + + DeepFormer: a hybrid network based on convolutional neural network and flow-attention mechanism for identifying the function of DNA sequences. + bbad095 + 10.1093/bib/bbad095 + + Identifying the function of DNA sequences accurately is an essential and challenging task in the genomic field. Until now, deep learning has been widely used in the functional analysis of DNA sequences, including DeepSEA, DanQ, DeepATT and TBiNet. However, these methods have the problems of high computational complexity and not fully considering the distant interactions among chromatin features, thus affecting the prediction accuracy. In this work, we propose a hybrid deep neural network model, called DeepFormer, based on convolutional neural network (CNN) and flow-attention mechanism for DNA sequence function prediction. In DeepFormer, the CNN is used to capture the local features of DNA sequences as well as important motifs. Based on the conservation law of flow network, the flow-attention mechanism can capture more distal interactions among sequence features with linear time complexity. We compare DeepFormer with the above four kinds of classical methods using the commonly used dataset of 919 chromatin features of nearly 4.9 million noncoding DNA sequences. Experimental results show that DeepFormer significantly outperforms four kinds of methods, with an average recall rate at least 7.058% higher than other methods. Furthermore, we confirmed the effectiveness of DeepFormer in capturing functional variation using Alzheimer's disease, pathogenic mutations in alpha-thalassemia and modification in CCCTC-binding factor (CTCF) activity. We further predicted the maize chromatin accessibility of five tissues and validated the generalization of DeepFormer. The average recall rate of DeepFormer exceeds the classical methods by at least 1.54%, demonstrating strong robustness. + © The Author(s) 2023. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com. + + + + Yao + Zhou + Z + + Key Laboratory of Smart Farming for Agricultural Animals, Huazhong Agricultural University, Wuhan 430070, China. + + + Hubei Key Laboratory of Agricultural Bioinformatics, Huazhong Agricultural University, Wuhan 430070, China. + + + College of Informatics, Huazhong Agricultural University, Wuhan 430070, China. + + + + Zhang + Wenjing + W + + College of Informatics, Huazhong Agricultural University, Wuhan 430070, China. + + + + Song + Peng + P + + College of Plant Science & Technology, Huazhong Agricultural University, Wuhan 430070, China. + + + + Hu + Yuxue + Y + + College of Informatics, Huazhong Agricultural University, Wuhan 430070, China. + + + + Liu + Jianxiao + J + 0000-0002-9165-4012 + + National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, China. + + + Key Laboratory of Smart Farming for Agricultural Animals, Huazhong Agricultural University, Wuhan 430070, China. + + + Hubei Key Laboratory of Agricultural Bioinformatics, Huazhong Agricultural University, Wuhan 430070, China. + + + College of Informatics, Huazhong Agricultural University, Wuhan 430070, China. + + + + eng + + + 31601078 + National Natural Science Foundation of China + + + + IRIFH202209 + Yingzi Tech & Huazhong Agricultural University Intelligent Research Institute of Food Health + + + + 2022HSZD031 + Major Project of Hubei Hongshan Laboratory + + + + 2662021JC008 + Fundamental Research Funds for the Central Universities + + + + 2022YFD1201504 + National Key Research and Development Program of China + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + England + Brief Bioinform + 100912837 + 1467-5463 + + IM + + DNA function prediction + convolutional neural network + flow-attention mechanism + linear attention mechanism + motif + +
+ + + + 2022 + 11 + 30 + + + 2023 + 01 + 19 + + + 2023 + 02 + 21 + + + 2023 + 3 + 14 + 12 + 33 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917472 + 7077271 + 10.1093/bib/bbad095 + + +
+ + + 36917477 + + 2023 + 03 + 14 + +
+ + 1552-9924 + + 131 + 3 + + 2023 + Mar + + + Environmental health perspectives + Environ Health Perspect + + The Echoes of Noise: Residential Exposure to Traffic and Risk of Tinnitus. + + 34001 + + 10.1289/EHP12762 + + + Adegboye + Oyelola + O + 0000-0002-9793-8024 + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Environ Health Perspect + 0330411 + 0091-6765 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 42 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + ppublish + + 36917477 + 10.1289/EHP12762 + + +
+ + + 36917476 + + 2023 + 03 + 14 + +
+ + 1477-0539 + + + 2023 + Mar + 14 + + + Organic & biomolecular chemistry + Org Biomol Chem + + Transition metal-catalyzed C-H/C-C activation and coupling with 1,3-diyne. + 10.1039/d3ob00238a + + This review provides a broad overview of the recent developments in the field of transition metal-catalyzed C-H/C-C bond activation and coupling with 1,3-diyne for assembling alkynylated heterocycles, bis-heterocycles, and 1,3-enynes. Transition metal-catalyzed inert bond (C-H/C-C) activation has been the focus of attention among synthetic chemists in recent times. Enormous developments have taken place in C-H/C-C bond activation chemistry in the last two decades. In recent years the use of 2π-unsaturated units as coupling partners for the synthesis of heterocycles through C-H/C-C bond activation and annulation sequence has received immense attention. Among the unsaturated units employed for assembling heterocycles, the use of 1,3-diynes has garnered significant attention due to its ability to render bis-heterocycles in a straightforward manner. The C-H bond activation and coupling with 1,3-diyne has been very much explored in recent years. However, the development of strategies for the use of 1,3-diynes in the analogous C-C bond activation chemistry is less explored. Earlier methods employed to assemble bis-heterocycle used heterocycles that were preformed and pre-functionalized via transition metal-catalyzed coupling reactions. The expensive pre-functionalized halo-heterocycles and sensitive and expensive heterocyclic metal reagents limit its broad application. However, the transition metal-catalyzed C-H activation obviates the need for expensive heterocyclic metal reagents and pre-functionalized halo-heterocycles. The C-H bond activation strategy makes use of C-H bonds as functional groups for effecting the transformation. This renders the overall synthetic sequence both step and cost economic. Hence, this strategy of C-H activation and subsequent reaction with 1,3-diyne could be used for the larger-scale synthesis of chemicals in the pharmaceutical industry. Despite these advances, there is still the possibility of exploration of earth-abundant and cost-effective first-row transition metals (Ni, Cu, Mn. Fe, etc.) for the synthesis of bis-heterocycles. Moreover, the Cp*-ligand-free, simple metal-salt-mediated synthesis of bis-heterocycles is also less explored. Thus, more exploration of reaction conditions for the Cp*-free synthesis of bis-heterocycles is called for. We hope this review will inspire scientists to investigate these unexplored domains. + + + + Pati + Bedadyuti Vedvyas + BV + http://orcid.org/0000-0002-4874-8558 + + School of Chemical Sciences, National Institute of Science Education and Research (NISER), Odisha 752050, India. pcr@niser.ac.in. + + + Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai 400094, India. + + + + Puthalath + Nitha Nahan + NN + + School of Chemical Sciences, National Institute of Science Education and Research (NISER), Odisha 752050, India. pcr@niser.ac.in. + + + Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai 400094, India. + + + + Banjare + Shyam Kumar + SK + http://orcid.org/0000-0001-5777-7281 + + School of Chemical Sciences, National Institute of Science Education and Research (NISER), Odisha 752050, India. pcr@niser.ac.in. + + + Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai 400094, India. + + + + Nanda + Tanmayee + T + + School of Chemical Sciences, National Institute of Science Education and Research (NISER), Odisha 752050, India. pcr@niser.ac.in. + + + Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai 400094, India. + + + + Ravikumar + Ponneri C + PC + http://orcid.org/0000-0002-5264-820X + + School of Chemical Sciences, National Institute of Science Education and Research (NISER), Odisha 752050, India. pcr@niser.ac.in. + + + Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai 400094, India. + + + + eng + + Journal Article + Review + + + 2023 + 03 + 14 + +
+ + England + Org Biomol Chem + 101154995 + 1477-0520 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 42 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917476 + 10.1039/d3ob00238a + + +
+ + + 36917481 + + 2023 + 03 + 14 + +
+ + 2042-650X + + + 2023 + Mar + 14 + + + Food & function + Food Funct + + Saccharomyces cerevisiae: a patulin degradation candidate both in vitro and in vivo. + 10.1039/d2fo03419k + + Patulin is one of the mycotoxins that exists in abundance in fruits and derivative products and is easily exposed in daily life, leading to various toxicities such as genotoxicity, teratogenicity, immunotoxicity, and carcinogenicity in the human body, while the efficient removal or degradation measures are still in urgent demand. In this work, Saccharomyces cerevisiae, a natural yeast with both patulin degradation and intestine damage protection abilities, was first applied to prevent and decrease the hazard after patulin intake. In vitro, Saccharomyces cerevisiae KD (S. cerevisiae KD) could efficiently degrade patulin at high concentrations. In a Canenorhabditis elegans (C. elegans) model fed on S. cerevisiae KD, locomotion, oxidative stress, patulin residual, intestine damage, and gene expression were investigated after exposure to 50 μg mL-1 patulin. The results demonstrated that S. cerevisiae KD could efficiently degrade patulin, as well as weaken the oxidative stress and intestinal damage caused by patulin. Moreover, S. cerevisiae KD could regulate the gene expression levels of daf-2 and daf-16 through the IGF-1 signaling pathway to control the ROS level and glutathione (GSH) content, thus decreasing intestinal damage. In summary, this work uncovers the outstanding characteristic of an edible probiotic S. cerevisiae KD in patulin degradation and biotoxicity alleviation and provides enlightenment toward solving the hazards caused by the accumulation of patulin. + + + + Zhu + Ruiyu + R + + College of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China. + + + College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China. + + + + Shan + Shuo + S + + College of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China. + + + + Zhou + Su + S + + Tea Research Institute, Zhejiang University, Hangzhou 310058, China. chuqiang@zju.edu.cn. + + + + Chen + Zhen + Z + + College of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China. + + + + Wu + Yuanfeng + Y + + College of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China. + + + + Liao + Wei + W + + College of Food Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China. + + + + Zhao + Chao + C + http://orcid.org/0000-0003-1096-632X + + College of Marine Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China. zhchao@live.cn. + + + + Chu + Qiang + Q + http://orcid.org/0000-0003-3075-3444 + + Tea Research Institute, Zhejiang University, Hangzhou 310058, China. chuqiang@zju.edu.cn. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + England + Food Funct + 101549033 + 2042-6496 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 43 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917481 + 10.1039/d2fo03419k + + +
+ + + 36917491 + + 2023 + 03 + 14 + +
+ + 1534-7796 + + + 2023 + Mar + 15 + + + Psychosomatic medicine + Psychosom Med + + Beliefs in Regulating Negative Emotions and Vagally-Mediated Heart-Rate Variability. Does Sex Make a Difference? + 10.1097/PSY.0000000000001191 + + This ecological study explored the association between regulatory emotional self-efficacy beliefs in managing negative emotions (RESE-NE) and heart rate variability (HRV), a measure of parasympathetic modulation of the heart that has been positively associated with a better ability to flexibly adjust to a changing environment and regulate emotions. + To test these associations, we used data from 161 adults working in relational professions (about 40% men; Mage = 40.45, SDage = 14.17) whose HRV was assessed continuously for 24 hours. + Individuals high in RESE-NE showed increased HRV levels (?? = -.05, p = .011). However, this effect was moderated by biological sex (?? = -0.18, p = .0001) such that RESE-NE positively and significantly predicted HRV for men (?? = .18, p = < .0001) but not for women (?? = -.001, p = .989). + All in all, our study provides initial empirical support for the theoretical expectation derived from social cognitive theory that RESE-NE is positively correlated with a physiological indicator of adaptability to the environmental demands. This was true only for men, likely due to sex differences in physiological stress reactivity and regulation. + Copyright © 2023 by the American Psychosomatic Society. + + + + Alessandri + Guido + G + 0000-0003-4731-5248 + + Sapienza, University of Rome. + + + + Filosa + Lorenzo + L + 0000-0002-9748-1351 + + Sapienza, University of Rome. + + + + Eisenberg + Nancy + N + 0000-0002-4780-4538 + + Arizona State University. + + + + Ottaviani + Cristina + C + 0000-0002-5240-4387 + + Sapienza, University of Rome. + + + + eng + + Journal Article + + + 2023 + 03 + 15 + +
+ + United States + Psychosom Med + 0376505 + 0033-3174 + + IM + Conflict of interest: The authors declare they have no conflict of interest to disclose. +
+ + + + 2023 + 3 + 14 + 12 + 43 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917491 + 10.1097/PSY.0000000000001191 + 00006842-990000000-00102 + + +
+ + + 36917490 + + 2023 + 03 + 14 + +
+ + 1477-9234 + + + 2023 + Mar + 14 + + + Dalton transactions (Cambridge, England : 2003) + Dalton Trans + + A chemiluminescent lantern: a coordination cage catalysed oxidation of luminol followed by chemiluminescence resonance energy-transfer. + 10.1039/d3dt00689a + + A molecule of luminol bound as guest inside a Co8 coordination cage host undergoes oxidation by H2O2 to generate chemiluminescence by a process in which the Co(II) ions in the cage superstructure activate the H2O2: accordingly the cage not only co-locates the reactants but also acts as a redox partner in the catalysis. The luminescence from oxidation of the cavity-bound luminol can transfer its excitation energy to surface-bound fluorescein molecules in an unusual example of Chemiluminescence Resonance Energy Transfer (CRET). + + + + Solea + Atena B + AB + http://orcid.org/0000-0002-8550-4886 + + Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK. m.d.ward@warwick.ac.uk. + + + + Ward + Michael D + MD + http://orcid.org/0000-0001-8175-8822 + + Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK. m.d.ward@warwick.ac.uk. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + England + Dalton Trans + 101176026 + 1477-9226 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 43 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917490 + 10.1039/d3dt00689a + + +
+ + + 36917482 + + 2023 + 03 + 14 + +
+ + 2040-3372 + + + 2023 + Mar + 14 + + + Nanoscale + Nanoscale + + Selective recognition of the amyloid marker single thioflavin T using DNA origami-based gold nanobipyramid nanoantennas. + 10.1039/d2nr06389a + + The development of effective methods for the detection of protein misfolding is highly beneficial for early stage medical diagnosis and the prevention of many neurodegenerative diseases. Self-assembled plasmonic nanoantennas with precisely tunable nanogaps show extraordinary electromagnetic enhancement, generating extreme signal amplification imperative for the design of ultrasensitive biosensors for point of care applications. Herein, we report the custom arrangement of Au nanobipyramid (Au NBP) monomer and dimer nanoantennas engineered precisely based on the DNA origami technique. Furthermore, we demonstrate the SERS based detection of thioflavin T (ThT), a well-established marker for the detection of amyloid fibril formation, where G-Quadruplexes govern the site-specific attachment of ThT in the plasmonic hotspot. This is the first study for the SERS based detection of the ThT dye attached specifically using a G-Quadruplex complex. The spectroscopic signals of ThT were greatly enhanced due to the designed nanoantennas demonstrating their potential as superior SERS substrates. This study paves the way for boosting the design of next-generation diagnostic tools for the specific and precise detection of various target disease biomarkers using molecular probes. + + + + Kaur + Charanleen + C + + Institute of Nano Science and Technology, Sector-81, Mohali, Punjab - 140306, India. tapasi@inst.ac.in. + + + + Kaur + Vishaldeep + V + + Institute of Nano Science and Technology, Sector-81, Mohali, Punjab - 140306, India. tapasi@inst.ac.in. + + + + Rai + Shikha + S + + Institute of Nano Science and Technology, Sector-81, Mohali, Punjab - 140306, India. tapasi@inst.ac.in. + + + + Sharma + Mridu + M + + Institute of Nano Science and Technology, Sector-81, Mohali, Punjab - 140306, India. tapasi@inst.ac.in. + + + + Sen + Tapasi + T + http://orcid.org/0000-0003-0243-178X + + Institute of Nano Science and Technology, Sector-81, Mohali, Punjab - 140306, India. tapasi@inst.ac.in. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + England + Nanoscale + 101525249 + 2040-3364 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 43 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917482 + 10.1039/d2nr06389a + + +
+ + + 36917493 + + 2023 + 03 + 14 + +
+ + 2050-084X + + 12 + + 2023 + Mar + 14 + + + eLife + Elife + + Novel repertoire of tau biosensors to monitor pathological tau transformation and seeding activity in living cells. + 10.7554/eLife.78360 + e78360 + + Aggregates of the tau protein are a well-known hallmark of several neurodegenerative diseases, collectively referred to as tauopathies, including frontal temporal dementia and Alzheimer's disease (AD). Monitoring the transformation process of tau from physiological monomers into pathological oligomers or aggregates in a high-throughput, quantitative manner and in a cellular context is still a major challenge in the field. Identifying molecules able to interfere with those processes is of high therapeutic interest. Here, we developed a series of inter- and intramolecular tau biosensors based on the highly sensitive Nanoluciferase (Nluc) binary technology (NanoBiT) able to monitor the pathological conformational change and self-interaction of tau in living cells. Our repertoire of tau biosensors reliably reports i. molecular proximity of physiological full-length tau at microtubules; ii. changes in tau conformation and self-interaction associated with tau phosphorylation, as well as iii. tau interaction induced by seeds of recombinant tau or from mouse brain lysates of a mouse model of tau pathology. By comparing biosensors comprising different tau forms (i.e. full-length or short fragments, wild-type, or the disease-associated tau(P301L) variant) further insights into the tau transformation process are obtained. Proof-of-concept data for the high-throughput suitability and identification of molecules interfering with the pathological tau transformation processes are presented. This novel repertoire of tau biosensors is aimed to boost the disclosure of molecular mechanisms underlying pathological tau transformation in living cells and to discover new drug candidates for tau-related neurodegenerative diseases. + © 2023, Cecon et al. + + + + Cecon + Erika + E + https://orcid.org/0000-0003-2387-9313 + + Institut Cochin, Inserm U1016, CNRS UMR 8104, Université de Paris, Paris, France. + + + + Oishi + Atsuro + A + https://orcid.org/0000-0003-1788-5485 + + Institut Cochin, Inserm U1016, CNRS UMR 8104, Université de Paris, Paris, France. + + + + Luka + Marine + M + + Institut Cochin, Inserm U1016, CNRS UMR 8104, Université de Paris, Paris, France. + + + + Ndiaye-Lobry + Delphine + D + + Institut Cochin, Inserm U1016, CNRS UMR 8104, Université de Paris, Paris, France. + + + + François + Arnaud + A + + Les Laboratoires Servier, Suresnes, France. + + + + Lescuyer + Mathias + M + + Institut Cochin, Inserm U1016, CNRS UMR 8104, Université de Paris, Paris, France. + + + + Panayi + Fany + F + + Les Laboratoires Servier, Suresnes, France. + + + + Dam + Julie + J + + Institut Cochin, Inserm U1016, CNRS UMR 8104, Université de Paris, Paris, France. + + + + Machado + Patricia + P + + Les Laboratoires Servier, Suresnes, France. + + + + Jockers + Ralf + R + https://orcid.org/0000-0002-4354-1750 + + Institut Cochin, Inserm U1016, CNRS UMR 8104, Université de Paris, Paris, France. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + England + Elife + 101579614 + 2050-084X + + IM + + Alzheimer's disease + Biosensors + Nanoluciferase + cell biology + human + microtubules + tau seeding + + EC, AO, ML, DN, AF, ML, FP, JD, PM, RJ No competing interests declared +
+ + + + 2022 + 03 + 03 + + + 2023 + 02 + 26 + + + 2023 + 3 + 14 + 12 + 52 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917493 + 10.7554/eLife.78360 + 78360 + + +
+ + + 36917494 + + 2023 + 03 + 14 + +
+ + 1439-7633 + + + 2023 + Mar + 14 + + + Chembiochem : a European journal of chemical biology + Chembiochem + + Constraining and modifying peptides using Pd-mediated cysteine allylation. + + e202300098 + + 10.1002/cbic.202300098 + + Over the past decades, several strategies for inducing and stabilizing secondary structure formation in peptides have been developed to increase their proteolytic stability and their binding affinity to specific interaction partners. Here, we report how our recently introduced chemoselective Pd-catalyzed cysteine allylation reaction can be extended to stapling and how the resulting alkene-containing staples themselves can be further modified to introduce additional probes into such stabilized peptides. The latter is demonstrated by introducing a fluorophore as well as a PEG moiety into different stapled peptides using bioorthogonal thiol-ene and Diels-Alder reactions. Furthermore, we investigated structural implications of our allyl staples when used to replace conformationally relevant disulfide bridges. To this end, we chose a selective binder of integrin α3β1 (LXY3), which is only active in its cyclic disulfide form. We replaced the disulfide bridge by different stapling reagents in order to increase stability and binding affinity towards integrin α3β1. + © 2023 Wiley-VCH GmbH. + + + + Kriegesmann + Julia + J + + Universität Wien Fakultät für Chemie: Universitat Wien Fakultat fur Chemie, Institute of Biological Chemistry, AUSTRIA. + + + + Schlatzer + Thomas + T + + Technische Universitat Graz, Organic Chemistry, AUSTRIA. + + + + Che + Kateryna + K + + Universität Wien Fakultät für Chemie: Universitat Wien Fakultat fur Chemie, Biological Chemistry, AUSTRIA. + + + + Altdorf + Claudia + C + + Syntab Therapeutics GmbH, Syntab, GERMANY. + + + + Huhmann + Susanne + S + + Universität Wien Fakultät für Chemie: Universitat Wien Fakultat fur Chemie, Biological Chemistry, AUSTRIA. + + + + Kählig + Hanspeter + H + + Universität Wien Fakultät für Chemie: Universitat Wien Fakultat fur Chemie, Organic Chemistry, AUSTRIA. + + + + Kurzbach + Dennis + D + + Universität Wien Fakultät für Chemie: Universitat Wien Fakultat fur Chemie, Biological Chemistry, AUSTRIA. + + + + Breinbauer + Rolf + R + + Graz University of Technology: Technische Universitat Graz, Organic Chemistry, AUSTRIA. + + + + Becker + Christian F W + CFW + + Universitat Wien, Institute of Biological Chemistry, Währinger Str. 38, 1090, Vienna, AUSTRIA. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Chembiochem + 100937360 + 1439-4227 + + IM + + Diels-Alder reaction + allylation reaction + peptide stapling + secondary peptide modification + +
+ + + + 2023 + 03 + 14 + + + 2023 + 02 + 06 + + + 2023 + 03 + 14 + + + 2023 + 3 + 14 + 12 + 52 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917494 + 10.1002/cbic.202300098 + + +
+ + + 36917487 + + 2023 + 03 + 14 + +
+ + 1534-7796 + + + 2023 + Mar + 15 + + + Psychosomatic medicine + Psychosom Med + + A Gene-Acculturation Study of Obesity Among U.S. Hispanic/Latinos: The Hispanic Community Health Study/Study of Latinos. + 10.1097/PSY.0000000000001193 + + In the United States, Hispanic/Latino adults face a high burden of obesity; yet, not all individuals are equally affected, partly due in part to this ethnic group's marked sociocultural diversity. We sought to analyze the modification of body mass index (BMI) genetic effects in Hispanic/Latino adults by their level of acculturation, a complex bio-social phenomenon that remains understudied. + Among 11,747 Hispanic/Latinos adults in the Hispanic Community Health Study/Study of Latinos aged 18-76 years from four urban communities (2008-2011), we 1) tested our hypothesis that the effect of a genetic risk score (GRS) for increased BMI may be exacerbated by higher levels of acculturation, and 2) examined if GRS acculturation interactions varied by gender or Hispanic/Latino background group. All genetic modeling controlled for relatedness, age, gender, principal components of ancestry, center, and complex study design within a Generalized Estimated Equation framework. + We observed an GRS increase of 0.m34 kg/m2 per risk allele in weighted mean BMI. The estimated main effect of GRS on BMI varied both across acculturation level, as well as across gender. The difference between high and low acculturation ranged from 0.03-0.23 kg/m2 per risk allele, but varied across acculturation measure and gender. + These results suggest the presence of effect modification by acculturation, with stronger effects on BMI among highly acculturated individuals and female immigrants. Future studies of obesity in the Hispanic/Latino community should account for sociocultural environments and consider their intersection with gender to better target obesity interventions. + Copyright © 2023 by the American Psychosomatic Society. + + + + Fernández-Rhodes + Lindsay + L + + + McArdle + Cristin E + CE + + Department of Biobehavioral Health, Pennsylvania State University, University Park, PA. + + + + Rao + Hridya + H + + Department of Biobehavioral Health, Pennsylvania State University, University Park, PA. + + + + Wang + Yujie + Y + + Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC. + + + + Martinez-Miller + Erline E + EE + + + Ward + Julia B + JB + + + Cai + Jianwen + J + + Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC. + + + + Sofer + Tamar + T + + Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA. + + + + Isasi + Carmen R + CR + + Departments of Epidemiology & Population Health and Pediatrics, Albert Einstein College of Medicine, Bronx, NY. + + + + North + Kari E + KE + + + eng + + Journal Article + + + 2023 + 03 + 15 + +
+ + United States + Psychosom Med + 0376505 + 0033-3174 + + IM + Funding - LFR was supported by the AHA Predoctoral Fellowship (13PRE16100015). HR was supported by Penn State Clinical and Translational Science Institute Translational Research Training Award (TL1TR002016) part of National Center for Advancing Translational Sciences at the National Institute of Health (NIH). The Hispanic Community Health Study/Study of Latinos is a collaborative study supported by contracts from the National Heart, Lung, and Blood Institute (NHLBI) to the University of North Carolina (N01-HC65233), University of Miami (N01-HC65234), Albert Einstein College of Medicine (N01-HC65235), Northwestern University (N01-HC65236), and San Diego State University (N01-HC65237). The following Institutes/Centers/Offices contribute to the HCHS/SOL through a transfer of funds to the NHLBI: National Center on Minority Health and Health Disparities, the National Institute of Deafness and Other Communications Disorders, the National Institute of Dental and Craniofacial Research, the National Institute of Diabetes and Digestive and Kidney Diseases, the National Institute of Neurological Disorders and Stroke, and the Office of Dietary Supplements. The Genetic Analysis Center at the University of Washington was supported by NHLBI and NIDCR contracts (HHSN268201300005C AM03 and MOD03). The authors declare no conflict of interest. +
+ + + + 2023 + 3 + 14 + 12 + 43 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917487 + 10.1097/PSY.0000000000001193 + 00006842-990000000-00103 + + +
+ + + 36917485 + + 2023 + 03 + 14 + +
+ + 1759-9679 + + + 2023 + Mar + 14 + + + Analytical methods : advancing methods and applications + Anal Methods + + Ultraviolet-induced fluorescence of oil spill recognition using a semi-supervised algorithm based on thickness and mixing proportion-emission matrices. + 10.1039/d2ay01776h + + In recent years, marine oil spill accidents have been occurring frequently during extraction and transportation, and seriously damage the ecological balance. Accurate monitoring of oil spills plays a vital role in estimating oil spill volume, determination of liability, and clean-up. The oil that leaks into natural environments is not a single type of oil, but a mixture of various oil products, and the oil film thickness on the sea surface is uneven under the influence of wind and waves. Increasing the mixed oil film thickness dimension and the mix proportion dimension has been proposed to weaken the effect of the detection environment on the fluorescence measurement results. To preserve the relationships between the data of oil films with different thicknesses and the relationships between the data of oil films with different mixing proportions, the three-dimensional fluorescence spectral data of mixed oil films on a seawater surface were measured in the laboratory, producing a thickness-fluorescence matrix and a proportion-fluorescence matrix. The nonlinear variation of the fluorescence spectra was investigated according to the fluorescence lidar equation. This work pre-processes the data by sum normalization and two-dimensional principal component analysis (2DPCA) and uses the dimensionality reduction results as two feature-point views. Then, semi-supervised classification of collaborative training (co-training) with K-nearest neighbors (KNN) and a decision tree (DT) is used to identify the samples. The results show that the average overall accuracy of this coupling model can reach 100%, which is 20.49% higher than that of the thickness-only view. Using unlabeled data can reduce the cost of data acquisition, improve the classification accuracy and generalization ability, and provide theoretical significance and application prospects for discrimination of spectrally similar oil species in natural marine environments. + + + + Gong + Bowen + B + http://orcid.org/0000-0002-8756-6730 + + Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun, Jilin Province, 130033, China. ciomp@ciomp.ac.cn. + + + University of Chinese Academy of Sciences, Beijing, 100049, China. @mails.ucas.ac.cn. + + + + Zhang + Hongji + H + + Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun, Jilin Province, 130033, China. ciomp@ciomp.ac.cn. + + + + Wang + Xiaodong + X + + Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun, Jilin Province, 130033, China. ciomp@ciomp.ac.cn. + + + + Lian + Ke + K + + Shanghai Institute of Spacecraft Equipment, Shanghai, 200240, China. + + + + Li + Xinkai + X + + Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun, Jilin Province, 130033, China. ciomp@ciomp.ac.cn. + + + + Chen + Bo + B + + Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun, Jilin Province, 130033, China. ciomp@ciomp.ac.cn. + + + + Wang + Hanlin + H + + Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun, Jilin Province, 130033, China. ciomp@ciomp.ac.cn. + + + University of Chinese Academy of Sciences, Beijing, 100049, China. @mails.ucas.ac.cn. + + + + Niu + Xiaoqian + X + + Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun, Jilin Province, 130033, China. ciomp@ciomp.ac.cn. + + + University of Chinese Academy of Sciences, Beijing, 100049, China. @mails.ucas.ac.cn. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + England + Anal Methods + 101519733 + 1759-9660 + + IM +
+ + + + 2023 + 3 + 14 + 12 + 43 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917485 + 10.1039/d2ay01776h + + +
+ + + 36917492 + + 2023 + 03 + 14 + +
+ + 1521-3765 + + + 2023 + Mar + 14 + + + Chemistry (Weinheim an der Bergstrasse, Germany) + Chemistry + + HAV-peptides attached to colloidal probes faithfully detect E-cadherins displayed on living cells. + + e202203904 + + 10.1002/chem.202203904 + + Cell adhesion molecules are crucial for a variety of biological processes, including wound healing, barrier formationand tissue homeostasis. One of them is E-cadherin which is generally found at adherent junctions between epithelialcells. To identify this molecule on the surface of cells, E-cadherin mimetic peptides with a critical aminoacid sequence of HAV (histidine-alanine-valine) were synthesized and attached to solid supported membranes coveringcolloidal probes. Two different functionalization strategies were established, one based on complexation of DOGSNTA(Ni) with a polyhistidine-tagged HAV-peptide and the other one relying on the formation of a HAV-lipopeptide usingin situ maleimide-thiol coupling. Binding studies were performed to verify the ability of the peptides to attachto the membrane surface. Compared to the non-covalent attachment via the His-tag, we achieved a higher yield bylipopeptide formation. Colloidal probes functionalized with HAV-peptides were employed to measure the presence of Ecadherinson living cells either using video particle tracking or force spectroscopy. Here, human HaCaT cells were examinedconfirming the specific interaction of the HAV-peptide with the E-cadherin of the cells. Statistical methods werealso used to determine the number of single-bond ruptures and the force of a single bond. These findings may be essentialfor the development of novel biosynthetic materials given their potential to become increasingly relevant in medicalapplications. + © 2023 Wiley-VCH GmbH. + + + + Toy + Silan + S + + Georg-August-Universitat Gottingen, IOBC, GERMANY. + + + + Dietz + Jörn + J + + Georg-August-Universitat Gottingen, IPC, GERMANY. + + + + Naumann + Peter + P + + Georg-August-Universitat Gottingen, IOBC, GERMANY. + + + + Trothe + Janina + J + + Georg-August-Universitat Gottingen, IOBC, GERMANY. + + + + Thomas + Franziska + F + + Heidelberg University, Institute of Organic Chemistry, GERMANY. + + + + Diederichsen + Ulf + U + + University of Göttingen: Georg-August-Universitat Gottingen, IOBC, GERMANY. + + + + Steinem + Claudia + C + + Georg-August-Universitat Gottingen, IOBC, GERMANY. + + + + Janshoff + Andreas + A + + University of Göttingen: Georg-August-Universitat Gottingen, Chemistry, Tammannstr. 6, 37077, Goettingen, GERMANY. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Germany + Chemistry + 9513783 + 0947-6539 + + IM + + cell adhesion + peptide mimetics, E-cadherin, solid supported membrane, colloidal probe microscopy + +
+ + + + 2023 + 02 + 24 + + + 2022 + 12 + 13 + + + 2023 + 03 + 10 + + + 2023 + 3 + 14 + 12 + 52 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917492 + 10.1002/chem.202203904 + + +
+ + + 36917484 + + 2023 + 03 + 14 + +
+ + 1534-7796 + + + 2023 + Feb + 27 + + + Psychosomatic medicine + Psychosom Med + + Psychoeducational Intervention for Reducing Heart Failure Patients' Rehospitalizations and Promoting Their Quality of Life and Post-Traumatic Growth at the 1-Year Follow-Up: A Randomized Clinical Trial. + 10.1097/PSY.0000000000001180 + + This study's aim was to verify whether a psychoeducational intervention, with a brief expressive post-traumatic growth (PTG) component, could reduce heart failure (HF) patients' hospital readmissions and promote their quality of life (QoL) and PTG. + It adopted a parallel randomized clinical trial design, and its participants comprised HF patients from a hospital in Southern Brazil. All the participants completed the World Health Organization Quality of Life Assessment (WHOQOL-BREF) and posttraumatic growth inventory (PTGI) questionnaires at the pre (T1:baseline) and post (T2) assessments of the intervention. While patients in the control group (CG) underwent only regular outpatient consultations, those in the intervention group (IG), supplemented their regular consultations, with two additional individual visits to promote health and psychological education. At the one-year follow-up, hospital readmissions were assessed. + Of the 142 patients recruited at baseline (72 and 70 in the CG and IG, respectively), as 19 dropped out at follow up, only 123 (63 and 60 in the CG and IG, respectively) were reassessed after approximately 378 days. They included 65% males, ages: 64 ± 11 years, 58% had low incomes, and 67% had less than high school education. The IG participants' risk of readmission got reduced by 52% (p = 0.023), and they also showed significant improvements in their total QoL and positive psychological growth at the six-month follow-up assessment. + The two-session psychoeducational intervention proved to be protective for Southern Brazilian HF patients in the IG, as it effectively reduced their hospital readmission rates by half compared to the CG, as well as improved their QoL and promoted their positive psychological growth.Trial Registration:ClinicalTrials.gov identifier: NCT04870918. + Copyright © 2023 by the American Psychosomatic Society. + + + + de Oliveira + Filipa Waihrich + FW + + + Nunes + Brenda Pereira + BP + + Hospital Geral de Caxias do Sul/General Hospital from Caxias do Sul University. + + + + Lucchese-Lobato + Fernanda + F + + + Schmidt + Márcia Moura + MM + + Instituto de Cardiologia/Institute of Cardiology of Rio Grande do Sul/University Foundation of Cardiology (IC/FUC). + + + + eng + + + ClinicalTrials.gov + + NCT04870918 + + + + + Journal Article + + + 2023 + 02 + 27 + +
+ + United States + Psychosom Med + 0376505 + 0033-3174 + + IM + Conflicts of Interest and Source of Funding: There are no conflicts of interests to disclose and no external sources of funding. +
+ + + + 2023 + 3 + 14 + 12 + 43 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917484 + 10.1097/PSY.0000000000001180 + 00006842-990000000-00098 + + +
+ + + 36917483 + + 2023 + 03 + 14 + +
+ + 1534-7796 + + + 2023 + Feb + 27 + + + Psychosomatic medicine + Psychosom Med + + All-cause and cause-specific mortality in parents following the death of a child in Taiwan: a population-based cohort study. + 10.1097/PSY.0000000000001182 + + Research from Western countries suggests that there is an increase in mortality in parents bereaved by the death of a child. Few studies have investigated this issue in a non-Western context. We explored the impact of the death of a child on parental mortality in Taiwan. + By linking population-based national registers, we followed the 2004-2014 birth cohort (N = 2,083,972) up until 2016. A total of 11,755 child deaths were identified. For each deceased child, 4 living children matched on age and sex were randomly selected; their parents were the comparison group. We used Cox proportional hazards regression models to compare the mortality risk of bereaved parents with the comparison group up until 2017. + Overall mortality risk was increased in parents who experienced the death of a child; the risk was higher in bereaved mothers, relative (adjusted Hazard ratio [aHR] = 4.91, 95% Confidence Interval [CI] = [3.96, 6.09]) than fathers: aHR [95%CI] =1.82 [1.55, 2.13]). The risk did not differ according to the sex of the child, but parents whose children died from unexpected causes (i.e. suicide/accidents/violence) were at greater risk than those dying from other causes. Risk was higher when the child was aged >1 year at the time of death than for deaths before age 1-year. + Parents who lost a child were at increased mortality risk in this East-Asian population. Special attention should be paid to the health of bereaved parents and explore the pathways leading to their risk. + Copyright © 2023 by the American Psychosomatic Society. + + + + Chen + Ying-Yeh + YY + + + Gunnell + David + D + + + Wu + Chia-Kai + CK + + Department of Health Care Management, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan. + + + + Hu + Ya-Hui + YH + + Department of Health Care Management, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan. + + + + Lee + Pei-Chen + PC + + + eng + + Journal Article + + + 2023 + 02 + 27 + +
+ + United States + Psychosom Med + 0376505 + 0033-3174 + + IM + Conflict of Interest: Non-declared +
+ + + + 2023 + 3 + 14 + 12 + 43 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917483 + 10.1097/PSY.0000000000001182 + 00006842-990000000-00096 + + +
+ + + 36917488 + + 2023 + 03 + 14 + +
+ + 1534-7796 + + + 2023 + Feb + 27 + + + Psychosomatic medicine + Psychosom Med + + Perceived Chronic Stress Is Associated with the German Diabetes Risk Score (GDRS) Among Adults Without Known Diabetes in Germany. + 10.1097/PSY.0000000000001183 + + There is evidence that psychological distress increases the risk of type 2 diabetes (T2D), but implications for prevention remain elusive. We examined the association between chronic stress and the German Diabetes Risk Score (GDRS) among adults without diabetes in Germany. + The study population consisted of 4,654 persons aged 18-64 years without known diabetes drawn from the German Health Interview and Examination Survey for Adults (DEGS1, 2008-2011). The predicted 5-year T2D risk (in %) was estimated using the GDRS. Perceived chronic stress was assessed by the Screening Scale of the Trier Inventory for the Assessment of Chronic Stress (TICS-SSCS) and categorized into 'up to average', 'above average', and 'high'. The cross-sectional association of chronic stress with log-transformed GDRS (expressed as geometric mean ratio, GMR) was analyzed in multivariable linear regression models. Covariables included age, sex, community size, region, educational level, living alone, social support, depression and alcohol use. + The mean predicted 5-year T2D risk was 2.7%, 2.9% and 3.0% for chronic stress up to average, above average and high chronic stress, respectively. Adjusted mean predicted 5-year risk was significantly higher among persons with chronic stress above average (GMR 1.10, 95% CI 1.02-1.19) and high stress (GMR 1.21, 95% CI 1.06-1.39) compared to persons with chronic stress up to average. No interactions with sex or other covariables were found. + Perceived chronic stress is independently associated with an increased predicted T2D risk in cross-sectional analysis and should be considered as T2D risk factor in longitudinal studies. + Copyright © 2023 by the American Psychosomatic Society. + + + + Nübel + Julia + J + + Robert Koch Institute, Department of Epidemiology and Health Monitoring, Berlin, Germany. + + + + Du + Yong + Y + + + Baumert + Jens + J + + + Hapke + Ulfert + U + + + Färber + Francesca + F + + + Heidemann + Christin + C + + + Scheidt-Nave + Christa + C + + + eng + + Journal Article + + + 2023 + 02 + 27 + +
+ + United States + Psychosom Med + 0376505 + 0033-3174 + + IM + Conflicts of Interest and Source of Funding: The authors declare that they have no competing interests. This work was supported by grants from the German Center for Diabetes Research (DZD), funded by the German Federal Ministry of Education and Research (grant numbers: HMGU2018Z3, HMGU2020Z4 and HMGU2022Z5), and grants from the German Federal Ministry of Health to develop a diabetes surveillance system in Germany (grant numbers: GE20190305 and 2522DIA700). DEGS1 was primarily funded by the German Federal Ministry of Health as part of the continuous national health monitoring and conducted by the Robert Koch-Institute. We wish to thank all the DEGS1 study participants. +
+ + + + 2023 + 3 + 14 + 12 + 43 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917488 + 10.1097/PSY.0000000000001183 + 00006842-990000000-00097 + + +
+ + + 36917486 + + 2023 + 03 + 14 + +
+ + 1534-7796 + + + 2023 + Mar + 15 + + + Psychosomatic medicine + Psychosom Med + + Functional somatic disorders, their subtypes, and their association with self-rated health in the German general population. + 10.1097/PSY.0000000000001187 + + The heterogeneous conceptualizations and classifications of persistent and troublesome physical symptoms impede their adequate clinical management. Functional somatic disorders (FSD) is a recently suggested interface concept that is aetiologically neutral and allows for dysfunctional psychobehavioral characteristics as well as somatic comorbidity. But its prevalence and impact are not yet known. + We analysed 2379 participants (mean age 48.3 yrs., 52.5% female) from a representative German community survey using operationalized FSD criteria. These criteria defined FSD types based on somatic symptom count, type and severity assessed by the Bodily Distress Syndrome Checklist. Additionally, the associations of those types with health concerns, comorbidity, psychological distress, and self-rated health were determined. + There were four clearly demarcated groups with no relevant bothering symptoms, with one or with few bothering symptoms from one organ system, and with multiple bothering symptoms from at least two organ systems. Psychological distress, health concerns and comorbidity steadily increased, and self-rated health decreased according to the number and severity of symptoms. Somatic symptom burden, health concerns and comorbidity independently predicted self-rated health, with no interaction effect between the latter two. + Our data support an FSD concept with two severity grades according to persistent and troublesome symptoms in one versus more organ systems. The delimitation of subtypes with psychobehavioral characteristics and/or with somatic comorbidity appears useful, while still allowing the demarcation of a group of participants with high symptom burden but without those additional characteristics. + Copyright © 2023 by the American Psychosomatic Society. + + + + Sattel + Heribert + H + + Department of Psychosomatic Medicine and Psychotherapy, Technical University of Munich, Munich, Germany. + + + + Häuser + Winfried + W + + Department of Internal Medicine 1, Klinikum Saarbrücken, Saarbrücken, Germany. + + + + Schmalbach + Bjarne + B + + Department of Medical Psychology and Medical Sociology, University of Mainz, Mainz, Germany. + + + + Brähler + Elmar + E + + + Henningsen + Peter + P + + Department of Psychosomatic Medicine and Psychotherapy, Technical University of Munich, Munich, Germany. + + + + Hausteiner-Wiehle + Constanze + C + + + eng + + Journal Article + + + 2023 + 03 + 15 + +
+ + United States + Psychosom Med + 0376505 + 0033-3174 + + IM + Conflicts of Interest: All authors declare no competing interests. +
+ + + + 2023 + 3 + 14 + 12 + 43 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917486 + 10.1097/PSY.0000000000001187 + 00006842-990000000-00101 + + +
+ + + 36917489 + + 2023 + 03 + 14 + +
+ + 1537-1719 + + + 2023 + Mar + 14 + + + Molecular biology and evolution + Mol Biol Evol + + Intergenic regions of Saccharomycotina yeasts are enriched in potential to encode transmembrane domains. + msad059 + 10.1093/molbev/msad059 + + Intergenic genomic regions have essential regulatory and structural roles that impose constraints on their sequences. But regions that do not currently encode proteins also carry the potential to do so in the future. De novo gene emergence, the evolution of novel genes out of previously non-coding sequences has now been established as a potent force for genomic novelty. Recently, it was shown that intergenic regions in the genome of S. cerevisiae harbor pervasive cryptic potential to, if theoretically translated, form transmembrane domains (TM domains) more frequently than expected by chance given their nucleotide composition, a property that we refer to as TM-forming enrichment. The source and biological relevance of this property is unknown. Here we expand the investigation into the TM-forming potential of intergenic regions to the entire Saccharomycotina budding yeast subphylum, in an effort to explain this property and understand its importance. We find pervasive but variable enrichment in TM-forming potential across the subphylum regardless of the composition and average size of intergenic regions. This cryptic property is evenly spread across the genome, cannot be explained by the hydrophobic content of the sequence, and does not appear to localize to regions containing regulatory motifs. This TM-forming enrichment specifically, and not the actual TM-forming potential, is associated, across genomes, with more TM domains in evolutionarily young genes. Our findings shed light on this newly discovered feature of yeast genomes and constitute a first step towards understanding its evolutionary importance. + © The Author(s) 2023. Published by Oxford University Press on behalf of Society for Molecular Biology and Evolution. + + + + Tassios + Emilios + E + + Institute for Fundamental Biomedical Research, Biomedical Sciences Research Center "Alexander Fleming", Vari, Greece. + + + School of Medicine, University of Crete, Heraklion, Greece. + + + + Nikolaou + Christoforos + C + + Institute for Bioinnovation, Biomedical Sciences Research Center "Alexander Fleming", Vari, Greece. + + + + Vakirlis + Nikolaos + N + 0000-0001-7606-6987 + + Institute for Fundamental Biomedical Research, Biomedical Sciences Research Center "Alexander Fleming", Vari, Greece. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Mol Biol Evol + 8501455 + 0737-4038 + + IM +
+ + + + 2022 + 09 + 09 + + + 2023 + 02 + 17 + + + 2023 + 03 + 09 + + + 2023 + 3 + 14 + 12 + 43 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917489 + 7077448 + 10.1093/molbev/msad059 + + +
+ + + 36917499 + + 2023 + 03 + 14 + +
+ + 1520-5851 + + + 2023 + Mar + 14 + + + Environmental science & technology + Environ Sci Technol + + Seasonal Oxygenation of Contaminated Floodplain Soil Releases Zn to Porewater. + 10.1021/acs.est.2c08764 + + Soil zinc contamination is a major threat to water quality and sensitive ecosystems. While Zn itself is not redox-active in soils, transitions in soil redox conditions may promote mobilization of Zn from common Zn hosts, including Mn(IV)/Fe(III)-(hydr)oxides and sulfide precipitates, leading to elevated concentrations of dissolved Zn in surface and groundwater and thus a potential increase in Zn transport and uptake. Here, we examined the impacts of hydrologic fluctuations and coupled redox transitions on Zn partitioning in contaminated riparian soil in a mountain watershed. We found that oxygenation of the soil profile during low water conditions caused a spike in porewater Zn concentrations, driven by oxidative dissolution of amorphous ZnS and weak partitioning of Zn to Fe(III)-(hydr)oxides, hydroxy-interlayer vermiculite, and vermiculite. In contrast to Pb, released Zn did not immediately adsorb to Fe(III)-(hydr)oxides or particulate organic matter due to less-favorable sorption of Zn than that of Pb and, further, decreased Zn sorption at slightly acidic pH. As aridification intensifies and groundwater levels decline throughout the western United States, contaminated floodplain soils in mountain watersheds may be frequently oxygenated, leading to increased mobilization of dissolved Zn, which will amplify the threat Zn poses to water quality and ecosystem health. + + + + Dewey + Christian + C + 0000-0003-1954-8298 + + Earth System Science Department, Stanford University, Stanford, California 94305, United States. + + + + Juillot + Farid + F + + Centre IRD Nouméa, Nouméa 98848, New Caledonia. + + + Institut de Minéralogie, de Physique des Matériaux et de Cosmochimie, Sorbonne Université, Paris 75005, France. + + + + Fendorf + Scott + S + 0000-0002-9177-1809 + + Earth System Science Department, Stanford University, Stanford, California 94305, United States. + + + + Bargar + John R + JR + 0000-0001-9303-4901 + + SLAC National Accelerator Laboratory, Menlo Park, California 94025, United States. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Environ Sci Technol + 0213155 + 0013-936X + + IM + + EXAFS + adsorption + contamination + redox + zinc + +
+ + + + 2023 + 3 + 14 + 12 + 53 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917499 + 10.1021/acs.est.2c08764 + + +
+ + + 36917507 + + 2023 + 03 + 14 + +
+ + 1465-3362 + + + 2023 + Mar + 14 + + + Drug and alcohol review + Drug Alcohol Rev + + Rolling through TikTok: An analysis of 3,4-methylenedioxymethamphetamine-related content. + 10.1111/dar.13640 + + TikTok has quickly gained popularity through its platforming of large amounts of short video content. Given its widespread popularity, unrestricted access and poor content monitoring may allow 3,4-methylenedioxymethamphetamine (MDMA)-related content to influence perception of MDMA use. We aimed to investigate how MDMA-related videos are portrayed on TikTok and explore MDMA-related harm reduction content. + MDMA-related hashtags and sounds were utilised to collect data from TikTok (n = 498). Video views, likes, comments and shares were recorded and quantified, and videos were coded for depiction/sentiment towards MDMA and thematic content. + The total sample view count was 82,413,781. Videos had a median view count of 28,900 (SD = ±561,645), median like count of 2269 (SD = ±102,904), median comment count of 52 (SD = ±755), and median share count of 34 (SD = ±3292). Most videos depicted MDMA neutrally (40.6%), while 34.9% were positive. MDMA intoxication was presumed in 40.2% of videos. The analysis produced seven themes, of which humour was the most common (80.5%). Harm reduction content was present in nine videos, viewed 999,700 times, and consisted of mixed subject matter. + Similar themes and issues surrounding drug-related content on TikTok are relevant to MDMA, and intoxication was present in a significant portion of the sample. Better monitoring or regulation of content could potentially offset harm that may arise from consumption of such content. Promotion of harm reduction content could also be trialled to minimise harm. + © 2023 The Authors. Drug and Alcohol Review published by John Wiley & Sons Australia, Ltd on behalf of Australasian Professional Society on Alcohol and other Drugs. + + + + Whelan + Jai + J + https://orcid.org/0000-0002-7543-5418 + + Department of Psychology, The University of Otago, Dunedin, New Zealand. + + + + Noller + Geoffrey E + GE + https://orcid.org/0000-0002-5451-028X + + Bioethics Centre, Dunedin School of Medicine, The University of Otago, Dunedin, New Zealand. + + + + Ward + Ryan D + RD + https://orcid.org/0000-0003-1036-0555 + + Department of Psychology, The University of Otago, Dunedin, New Zealand. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Australia + Drug Alcohol Rev + 9015440 + 0959-5236 + + IM + + MDMA + social media + +
+ + + + 2023 + 02 + 09 + + + 2022 + 09 + 29 + + + 2023 + 02 + 12 + + + 2023 + 3 + 14 + 13 + 2 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917507 + 10.1111/dar.13640 + + + REFERENCES + + Holland J, editor. Ecstasy: the complete guide: a comprehensive look at the risks and benefits of MDMA. Rochester: Park Street Press; 2001. + + + Passie T, Benzenhöfer U. The history of MDMA as an underground drug in the United States, 1960-1979. J Psychoactive Drugs. 2016;48:67-75. + + + Mitchell JM, Bogenschutz M, Lilienstein A, Harrison C, Kleiman S, Parker-Guilbert K, et al. MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study. Nat Med. 2021;27:1025-33. + + + Mounteney J, Griffiths P, Bo A, Cunningham A, Matias J, Pirona A. Nine reasons why ecstasy is not quite what it used to be. Int J Drug Policy. 2018;2018(51):36-41. + + + United Nations Office of Drugs and Crime. World drug report 2022. Booklet 4. Drug market trends of cocaine, amphetamine-type stimulants, and novel psychoactive substances. 2022. Availble from: https://www.unodc.org/res/wdr2022/MS/WDR22_Booklet_4.pdf + + + European Monitoring Centre for Drugs and Drug Addiction. European drug report 2014: trends and developments. Luxembourg: Publications Office of the European Union; 2014. Available from: https://www.emcdda.europa.eu/system/files/publications/963/TDAT14001ENN.pdf + + + European Monitoring Centre for Drugs and Drug Addiction. European drug report 2022: trends and developments. Luxembourg: Publications Office of the European Union; 2022. Available from: https://www.emcdda.europa.eu/system/files/publications/14644/TDAT22001ENN.pdf + + + Nutt DJ, King LA, Phillips LD. Drug harms in the UK: a multicriteria decision analysis. Lancet. 2010;376:1558-65. + + + Steers MN, Moreno MA, Neighbours C. The influence of social media on addictive behaviours in college students. Curr Addict Rep. 2016;3:343-8. + + + Davis JP, Pedersen ER, Tucker JS, Dunbar MS, Seelam R, Shih R, et al. Long-term associations between substance use-related media exposure, descriptive norms, and alcohol use from adolescence to young adulthood. J Youth Adolesc. 2019;8:1311-26. + + + Palamar JJ, Acosta P, Cleland CM. The influence of viewing a headline about ecstasy/Molly adulteration on future intentions to use. J Subst Use. 2020;25:95-100. + + + Palamar JJ, Le A. Media coverage about medical benefits of MDMA and ketamine affects perceived likelihood of engaging in recreational use. Addict Res Theory. 2022;30:96-103. + + + Rutherford BN, Lim CCW, Johnson B, Cheng B, Chung J, Huang S, et al. #TurntTrending: a systematic review of substance use portrayals on social media platforms. Addiction. 2023;118:206-17. + + + TikTok. Thanks a billion! | TikTok Newsroom 2021. Available from: https://newsroom.tiktok.com/en-us/1-billion-people-on-tiktok + + + Proulx M. Weekly usage of TikTok surpasses Instagram among US Gen Z Youth. Forrester 2021. Available from: https://www.forrester.com/blogs/weekly-usage-of-tiktok-surpasses-instagram-among-us-gen-z-youth + + + Qustodio. Social Media | Qustodio. 2022. Available from: https://www.qustodio.com/en/social-media-qustodio-annual-data-report-2021 + + + Russell AM, Davis RE, Ortega JM, Colditz JB, Primack B, Barry AE. # alcohol: portrayals of alcohol in top videos on TikTok. J Stud Alcohol Drugs. 2021;82:615-22. + + + Rutherford BN, Sun T, Johnson B, Co S, Lim TL, Lim CC, et al. Getting high for likes: exploring cannabis-related content on TikTok. Drug Alcohol Rev. 2022;41:1119-25. + + + Sun T, Lim CC, Chung J, Cheng B, Davidson L, Tisdale C, et al. Vaping on TikTok: a systematic thematic analysis. Tob Control. 2021;32:251-4. https://doi.org/10.1136/tobaccocontrol-2021-056619 + + + TikTok. Community Guidelines. 2022. Available from: https://www.tiktok.com/community-guidelines?lang=en + + + Curtis BL, Lookatch SJ, Ramo DE, McKay JR, Feinn RS, Kranzler HR. Meta-analysis of the association of alcohol-related social media use with alcohol consumption and alcohol-related problems in adolescents and young adults. Alcohol Clin Exp Res. 2018;42:978-86. + + + Willoughby JF, Hust SJ, Li J, Couto L. Exposure to pro and anti-cannabis social media messages and teens' and college students' intentions to use cannabis. Health Commun. 2023. Epub ahead of print. https://doi.org/10.1080/10410236.2022.2162707 + + + Topp L, Hall W, Hando J. Is there a dependence syndrome for ecstasy? (Report No. 51) National Drug and Alcohol Research Centre 1997. Available from: https://ndarc.med.unsw.edu.au/sites/default/files/ndarc/resources/TR.051.pdf + + + Degenhardt L, Bruno R, Topp L. Is ecstasy a drug of dependence? Drug Alcohol Depend. 2010;107:1-10. + + + +
+ + + 36917512 + + 2023 + 03 + 14 + +
+ + 1465-3362 + + + 2023 + Mar + 14 + + + Drug and alcohol review + Drug Alcohol Rev + + Three years of minimum unit pricing in the Northern Territory, what does the evidence say? + 10.1111/dar.13641 + + + Taylor + Nicholas + N + https://orcid.org/0000-0002-8700-5909 + + National Drug Research Institute, Curtin University, Melbourne, Australia. + + + School of Psychology, Deakin University, Geelong, Australia. + + + The Burnet Institute, Melbourne, Australia. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + Australia + Drug Alcohol Rev + 9015440 + 0959-5236 + + IM +
+ + + + 2023 + 02 + 20 + + + 2022 + 10 + 24 + + + 2023 + 02 + 22 + + + 2023 + 3 + 14 + 13 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917512 + 10.1111/dar.13641 + + + REFERENCES + + Skov SJ, Chikritzhs TN, Li SQ, Pircher S, Whetton S. How much is too much? Alcohol consumption and related harm in the Northern Territory. Med J Aust. 2010;193:269-72. + + + Australian Bureau of Statistics. National Aboriginal and Torres Strait islander health survey, Australia, 2018-19. Canberra: Australian Bureau of Statistics; 2019. + + + Clifford S, Smith JA, Livingston M, Wright CJC, Griffiths KE, Miller PG. A historical overview of legislated alcohol policy in the Northern Territory of Australia: 1979-2021. BMC Public Health. 2021;21:1921. + + + Northern Territory Legislative Assembly. Alcohol policies and legislation reform: floor Price. Darwin: Government of the Northern Territory; 2018. + + + Babor TF, Casswell S, Graham K, Huckle T, Livingston M, Österberg E, et al. Alcohol: no ordinary commodity: research and public policy. 3rd ed. Oxford: Oxford University Press; 2022. + + + Chikritzhs T, Gray D, Lyons Z, Saggers S. Restrictions on the sale and supply of alcohol: evidence and outcomes. Perth: National Drug Research Institute, Curtin University of Technology; 2007. p. 174067533-9. + + + Stockwell T, Crosbie D. Supply and demand for alcohol in Australia: relationships between industry structures, regulation and the marketplace. Int J Drug Policy. 2001;12:139-52. + + + Miller P, Coomber K, Smith J, Livingston M, Stevens M, Guthridge S, et al. Learning from alcohol (policy) reforms in the Northern Territory (LEARNT): protocol for a mixed-methods study examining the impacts of the banned drinker register. BMJ Open. 2022;12:e058614. + + + World Health Organization. No place for cheap alcohol: the potential value of minimum pricing for protecting lives. 2022. + + + Frontier Economics. Evaluation of the minimum unit Price of alcohol in the Northern Territory. Darwin, Australia: Prepared for the Northern Territory Department of Health; 2022. + + + Foundation for Alcohol Research and Education. Northern Territory alcohol harm-reduction report. Canberra: Foundation for Alcohol Research and Education; 2019. + + + Coomber K, Miller P, Taylor N, Livingston M, Smith J, Buykx P, et al. Investigating the introduction of the alcohol minimum unit price in the Northern Territory. Final Report (December 2019). Geelong, Australia: Deakin University. Prepared for the Northern Territory Department of Health; 2019. + + + Wright C, McAnulty GR, Secombe PJ. The effect of alcohol policy on intensive care unit admission patterns in Central Australia: a before-after cross-sectional study. Anaesth Intensive Care. 2021;49:35-43. + + + Taylor N, Miller P, Coomber K, Livingston M, Scott D, Buykx P, et al. The impact of a minimum unit price on wholesale alcohol supply trends in the Northern Territory, Australia. Aust N Z J Public Health. 2021;45:26-33. + + + O'Brien JW, Tscharke BJ, Bade R, Chan G, Gerber C, Mueller JF, et al. A wastewater-based assessment of the impact of a minimum unit price (MUP) on population alcohol consumption in the Northern Territory, Australia. Addiction. 2022;117:243-9. + + + Holmes J, Angus C, Boyd J, Buykx P, Brennan A, Gardiner K, et al. Evaluating the impact of minimum unit pricing in Scotland on people who are drinking at harmful levels. Edinburgh: HRB National Drugs Library; 2022. + + + Gruenewald PJ, Ponicki WR, Holder HD, Romelsjö A. Alcohol prices, beverage quality, and the demand for alcohol: quality substitutions and price elasticities. Alcohol Clin Exp Res. 2006;30:96-105. + + + Coomber K, Miller P, Taylor N, Livingston M, Smith J, Buykx P, et al. Investigating the introduction of the alcohol minimum unit price in the Northern Territory. Darwin, Australia: Deakin University for the Northern territory Government; 2020. Available from: https://alcoholreform.nt.gov.au/__data/assets/pdf_file/0007/818278/investigating-introduction-of-alcohol-minimum-unit-price-nt-final-report.pdf + + + World Health Organization. International guide for monitoring alcohol consumption and related harm. Geneva, Switzerland: World Health Organization; 2000. + + + Nepal S, Kypri K, Attia J, Chikritzhs T, Miller PG. Indicators for estimating trends in alcohol-related assault: evaluation using police data from Queensland, Australia. Inj Prev. 2019;25:444-7. + + + Brick J, Carpenter JA. The identification of alcohol intoxication by police. Alcohol Clin Exp Res. 2001;25:850-5. + + + +
+ + + 36917495 + + 2023 + 03 + 14 + +
+ + 1473-5644 + + 72 + 3 + + 2023 + Mar + + + Journal of medical microbiology + J Med Microbiol + + The foundations of aetiology: a common language for infection science. + 10.1099/jmm.0.001637 + + With the adoption of infection science as an umbrella term for the disciplines that inform our ideas of infection, there is a need for a common language that links infection's constituent parts. This paper develops a conceptual framework for infection science from the major themes used to understand causal relationships in infectious diseases. The paper proposes using the four main themes from the Principia Aetiologica to classify infection knowledge into four corresponding domains: Clinical microbiology, Public health microbiology, Mechanisms of microbial disease and Antimicrobial countermeasures. This epistemology of infection gives form and process to a revised infection ontology and an infectious disease heuristic. Application of the proposed epistemology has immediate practical implications for organization of journal content, promotion of inter-disciplinary collaboration, identification of emerging priority themes, and integration of cross-disciplinary areas such as One Health topics and antimicrobial resistance. Starting with these foundations, we can build a coherent narrative around the idea of infection that shapes the practice of infection science. + + + + Inglis + Timothy J J + TJJ + + School of Medicine, University of Western Australia, Nedlands, WA 6009, Australia. + + + PathWest Laboratory Medicine WA, Nedlands,, WA 6009, Australia. + + + Western Australian Country Health Service, Perth, WA 6000, Australia. + + + + eng + + Journal Article + +
+ + England + J Med Microbiol + 0224131 + 0022-2615 + + IM + + antimicrobial agents + antimicrobial resistance + clinical microbiology + infection science + microbial forensics + molecular epidemiology + one health + ontology of infection + pathogenesis + pathophysiology + public health microbiology + root cause analysis + +
+ + + + 2023 + 3 + 14 + 12 + 52 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + ppublish + + 36917495 + 10.1099/jmm.0.001637 + + +
+ + + 36917497 + + 2023 + 03 + 14 + +
+ + 1552-5775 + + 27 + 1 + + 2023 + Mar + 15 + + + The Permanente journal + Perm J + + Continued Progress for The Permanente Journal (Reimagined). + + 1-2 + + 10.7812/TPP/23.026 + + + Holt + G Richard + GR + + Editor-in-Chief, The Permanente Journal, Professor Emeritus, Department of Otolaryngology-Head and Neck Surgery; University of Texas Health Science Center at San Antonio, San Antonio, TX, USA; Associate Professor of Clinical and Applied Science Education, University of the Incarnate Word School of Medicine, San Antonio, TX, USA. + + + + eng + + Journal Article + + + 2023 + 03 + 15 + +
+ + United States + Perm J + 9800474 + 1552-5767 + + IM + + academic + education + medical education + +
+ + + + 2023 + 3 + 14 + 12 + 53 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + ppublish + + 36917497 + 10.7812/TPP/23.026 + + +
+ + + 36917508 + + 2023 + 03 + 14 + +
+ + 1526-7598 + + + 2023 + Mar + 14 + + + Anesthesia and analgesia + Anesth Analg + + The Perioperative Frontal Relative Ratio of the Alpha Power of Electroencephalography for Predicting Postoperative Delirium After Highly Invasive Surgery: A Prospective Observational Study. + 10.1213/ANE.0000000000006424 + + We investigated the associations between postoperative delirium (POD) and both the relative ratio of the alpha (α)-power of electroencephalography (EEG) and inflammatory markers in a prospective, single-center observational study. + We enrolled 84 patients who underwent radical cancer surgeries with reconstruction for esophageal cancer, oral floor cancer, or pharyngeal cancer under total intravenous anesthesia. We collected the perioperative EEG data and the perioperative data of the inflammatory markers, including neutrophil gelatinase-associated lipocalin, presepsin, procalcitonin, C-reactive protein, and the neutrophil-lymphocyte ratio (NLR). The existence of POD was evaluated based on the Intensive Care Delirium Screening Checklist. We compared the time-dependent changes in the relative ratio of the EEG α-power and inflammatory markers between the patients with and without POD. + Four of the 84 patients were excluded from the analysis. Of the remaining 80 patients, 25 developed POD and the other 55 did not. The relative ratio of the α-power at baseline was significantly lower in the POD group than the non-POD group (0.18 ± 0.08 vs 0.28 ± 0.11, P < .001). A time-dependent decline in the relative ratio of α-power in the EEG during surgery was observed in both groups. There were significant differences between the POD and non-POD groups in the baseline, 3-h, 6-h, and 9-h values of the relative ratio of α-power. The preoperative NLR of the POD group was significantly higher than that of the non-POD group (2.88 ± 1.04 vs 2.22 ± 1.00, P < .001), but other intraoperative inflammatory markers were comparable between the groups. Two multivariable logistic regression models demonstrated that the relative ratio of the α-power at baseline was significantly associated with POD. + Intraoperative frontal relative ratios of the α-power of EEG were associated with POD in patients who underwent radical cancer surgery. Intraoperative EEG monitoring could be a simple and more useful tool for predicting the development of postoperative delirium than measuring perioperative acute inflammatory markers. A lower relative ratio of α-power might be an effective marker for vulnerability of brain and ultimately for the development of POD. + Copyright © 2023 International Anesthesia Research Society. + + + + Kinoshita + Hirotaka + H + + From the Department of Anesthesiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan. + + + + Saito + Junichi + J + + From the Department of Anesthesiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan. + + + + Kushikata + Tetsuya + T + + From the Department of Anesthesiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan. + + + + Oyama + Tasuku + T + + From the Department of Anesthesiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan. + + + + Takekawa + Daiki + D + + From the Department of Anesthesiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan. + + + + Hashiba + Eiji + E + + Division of Intensive Care, Hirosaki University Medical Hospital, Hirosaki, Japanand. + + + + Sawa + Teiji + T + + Department of Anesthesiology, School of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan. + + + + Hirota + Kazuyoshi + K + + From the Department of Anesthesiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Anesth Analg + 1310650 + 0003-2999 + + IM + The authors declare no conflicts of interest. +
+ + + + 2023 + 3 + 14 + 13 + 2 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917508 + 10.1213/ANE.0000000000006424 + 00000539-990000000-00527 + + + + Boone MD, Sites B, von Recklinghausen FM, Mueller A, Taenzer AH, Shaefi S. Economic burden of postoperative neurocognitive disorders among US medicare patients. JAMA Netw Open. 2020;3:e208931. + + + Silverstein JH, Deiner SG. Perioperative delirium and its relationship to dementia. Prog Neuropsychopharmacol Biol Psychiatry. 2013;43:108–115. + + + Evered L, Silbert B, Knopman DS, et al. Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery-2018. Anesthesiology. 2018;129:872–879. + + + Subramaniyan S, Terrando N. Neuroinflammation and perioperative neurocognitive disorders. Anesth Analg. 2019;128:781–788. + + + Li Z, Zhu Y, Kang Y, Qin S, Chai J. Neuroinflammation as the underlying mechanism of postoperative cognitive dysfunction and therapeutic strategies. Front Cell Neurosci. 2022;16:843069. + + + Kinoshita H, Saito J, Takekawa D, Ohyama T, Kushikata T, Hirota K. Availability of preoperative neutrophil-lymphocyte ratio to predict postoperative delirium after head and neck free-flap reconstruction: a retrospective study. PLoS One. 2021;16:e0254654. + + + Oyama T, Kinoshita H, Takekawa D, Saito J, Kushikata T, Hirota K. Higher neutrophil-to-lymphocyte ratio, mean platelet volume, and platelet distribution width are associated with postoperative delirium in patients undergoing esophagectomy: a retrospective observational study. J Anesth. 2022;36:58–67. + + + Liu X, Yu Y, Zhu S. Inflammatory markers in postoperative delirium (POD) and cognitive dysfunction (POCD): a meta-analysis of observational studies. PLoS One. 2018;13:e0195659. + + + Noah AM, Almghairbi D, Evley R, Moppett IK. Preoperative inflammatory mediators and postoperative delirium: systematic review and meta-analysis. Br J Anaesth. 2021;127:424–434. + + + Lassig AAD, Lindgren BR, Itabiyi R, Joseph AM, Gupta K. Excessive inflammation portends complications: wound cytokines and head and neck surgery outcomes. Laryngoscope. 2019;129:E238–E246. + + + Haga Y, Beppu T, Doi K, et al. Systemic inflammatory response syndrome and organ dysfunction following gastrointestinal surgery. Crit Care Med. 1997;25:1994–2000. + + + Takeuchi M, Takeuchi H, Fujisawa D, et al. Incidence and risk factors of postoperative delirium in patients with esophageal cancer. Ann Surg Oncol. 2012;19:3963–3970. + + + Raats JW, van Eijsden WA, Crolla RM, Steyerberg EW, van der Laan L. Risk factors and outcomes for postoperative delirium after major surgery in elderly patients. PLoS One. 2015;10:e0136071. + + + Purdon PL, Pavone KJ, Akeju O, et al. The ageing brain: age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia. Br J Anaesth. 2015;115(suppl 1):i46–i57. + + + Koch S, Feinkohl I, Chakravarty S, et al. Cognitive impairment is associated with absolute intraoperative frontal α-band power but not with baseline α-band power: a pilot study. Dement Geriatr Cogn Disord. 2019;48:83–92. + + + Dekens DW, Eisel ULM, Gouweleeuw L, Schoemaker RG, De Deyn PP, Naudé PJW. Lipocalin 2 as a link between ageing, risk factor conditions and age-related brain diseases. Ageing Res Rev. 2021;70:101414. + + + Hou YS, Wang H, Chen H, Wu LF, Lu LF, He Y. Pathfast presepsin assay for early diagnosis of systemic inflammatory response syndrome in patients with nephrolithiasis. Biomed Res Int. 2015;2015:792572. + + + Bergeron N, Dubois MJ, Dumont M, Dial S, Skrobik Y. Intensive care delirium screening checklist: evaluation of a new screening tool. Intensive Care Med. 2001;27:859–864. + + + Hesse S, Kreuzer M, Hight D, et al. Association of electroencephalogram trajectories during emergence from anaesthesia with delirium in the postanaesthesia care unit: an early sign of postoperative complications. Br J Anaesth. 2019;122:622–634. + + + Giattino CM, Gardner JE, Sbahi FM, et al. Intraoperative frontal alpha-band power correlates with preoperative neurocognitive function in older adults. Front Syst Neurosci. 2017;11:24. + + + Fritz BA, Kalarickal PL, Maybrier HR, et al. Intraoperative electroencephalogram suppression predicts postoperative delirium. Anesth Analg. 2016;122:234–242. + + + Fritz BA, Maybrier HR, Avidan MS. Intraoperative electroencephalogram suppression at lower volatile anaesthetic concentrations predicts postoperative delirium occurring in the intensive care unit. Br J Anaesth. 2018;121:241–248. + + + Cantero JL, Atienza M, Gomez-Herrero G, et al. Functional integrity of thalamocortical circuits differentiates normal aging from mild cognitive impairment. Hum Brain Mapp. 2009;30:3944–3957. + + + Purdon PL, Pierce ET, Mukamel EA, et al. Electroencephalogram signatures of loss and recovery of consciousness from propofol. Proc Natl Acad Sci U S A. 2013;110:E1142–E1151. + + + John ER, Prichep LS, Kox W, et al. Invariant reversible QEEG effects of anesthetics. Conscious Cogn. 2001;10:165–183. + + + Dillon ST, Vasunilashorn SM, Ngo L, et al. Higher C-reactive protein levels predict postoperative delirium in older patients undergoing major elective surgery: a longitudinal nested case-control study. Biol Psychiatry. 2017;81:145–153. + + + Shao YR, Kahali P, Houle TT, et al. Low frontal alpha power is associated with the propensity for burst suppression: an electroencephalogram phenotype for a “vulnerable brain.” Anesth Analg. 2020;131:1529–1539. + + + Wildes TS, Mickle AM, Ben Abdallah A, et al. Effect of electroencephalography-guided anesthetic administration on postoperative delirium among older adults undergoing major surgery: the ENGAGES randomized clinical trial. JAMA. 2019;321:473–483. + + + Kawano T, Eguchi S, Iwata H, Tamura T, Kumagai N, Yokoyama M. Impact of preoperative environmental enrichment on prevention of development of cognitive impairment following abdominal surgery in a rat model. Anesthesiology. 2015;123:160–170. + + + Zhang H, Chen T, Ren J, et al. Pre-operative exercise therapy triggers anti-inflammatory trained immunity of Kupffer cells through metabolic reprogramming. Nat Metab. 2021;3:843–858. + + + +
+ + + 36917496 + + 2023 + 03 + 14 + +
+ + 1365-2761 + + + 2023 + Mar + 14 + + + Journal of fish diseases + J Fish Dis + + Comparative histopathology of livers from Baltic cod infected with the parasitic nematode Contracaecum osculatum. + 10.1111/jfd.13776 + + Infection levels with the parasitic nematode Contracaecum osculatum in Eastern Baltic cod have increased in the last decades. Eastern Baltic cod is transport host for this parasite that has a high affinity for the liver of the fish. The liver is a highly vital organ and damage to the liver tissue can result in reduced functionality of the organ. Previous studies have revealed that cod with high infections loads reveal impaired physiological performance, reduced nutritional condition and show signs of having a liver disease. Yet, little is known about the pathological changes and inflammatory reactions of the cod liver related to the infections. In this study, we performed histological examinations on 30 Baltic cod livers caught in the eastern part of the Baltic Sea (length; 38 ± 0.9 cm, weight; 454 ± 34.8 gram) and three Sound cod livers (length; 63 ± 2.9 cm, weight; 3396 ± 300.2 gram) to categorize the degree of inflammation and its relation to pathological changes in infected cod livers. We further investigated how C. osculatum infection levels varied with intensity of inflammation and co-infections. We found that high infection loads with C. osculatum caused severe inflammation in the liver tissue of cod and reduced fat content of the hepatocytes. Conspicuous amounts of glycogen were found in the muscle and intestinal epithelial cells of the nematodes and parasitic co-infections occurred more frequently in the most heavily infected livers. + © 2023 The Authors. Journal of Fish Diseases published by John Wiley & Sons Ltd. + + + + Behrens + Jane W + JW + https://orcid.org/0000-0002-0136-9681 + + National Institute of Aquatic Resources, Technical University of Denmark (DTU Aqua), Kgs. Lyngby, Denmark. + + + + Ryberg + Marie Plambech + MP + https://orcid.org/0000-0002-4485-9576 + + National Institute of Aquatic Resources, Technical University of Denmark (DTU Aqua), Kgs. Lyngby, Denmark. + + + + Chondromatidou + Virginia + V + https://orcid.org/0009-0002-9160-0783 + + National Institute of Aquatic Resources, Technical University of Denmark (DTU Aqua), Kgs. Lyngby, Denmark. + + + + Iburg + Tine Moesgaard + TM + https://orcid.org/0000-0003-0246-5146 + + National Institute of Aquatic Resources, Technical University of Denmark (DTU Aqua), Kgs. Lyngby, Denmark. + + + + eng + + + The European Maritime and Fisheries Fund and The Danish Fisheries Agency (33113-B-17-110 and 33113-B-20-161). + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + England + J Fish Dis + 9881188 + 0140-7775 + + IM + + +Gadus morhua + + hepatocytes + liver disease + liver worm + parasites + +
+ + + + 2023 + 02 + 14 + + + 2022 + 12 + 14 + + + 2023 + 02 + 16 + + + 2023 + 3 + 14 + 12 + 52 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917496 + 10.1111/jfd.13776 + + + REFERENCES + + Aspholm, P. E., Ugland, K. I., Jødestøl, K. A., & Berland, B. (1995). Sealworm (Pseudoterranova decipiens) infection in common seals (Phoca vitulina) and potential intermediate fish hosts from the outer Oslofjord. International Journal for Parasitology, 25(3), 367-373. + + + Black, D., & Love, R. M. (1986). The sequential mobilisation and restoration of energy reserves in tissues of Atlantic cod during starvation and refeeding. Journal of Comparative Physiology B, 156, 469-479. + + + Borucinska, J. D., Morka, D., Grabowski, Z., & Smith, H. (2017). A follow-up study of selected biomarkers of health in cod Gadus morhua L. collected from the southern Baltic off the polish coast. Journal of Fish Diseases, 40(12), 1883-1894. + + + Bruno, D. W., Nowak, B., & Elliott, D. G. (2006). Guide to the identification of fish protozoan and metazoan parasites in stained tissue sections. Diseases of Aquatic Organisms, 70(1-2), 1-36. + + + Buchmann, K. (2007). An introduction to fish parasitological Methods: Classical and molecular techniques. Biofolia. + + + Buchmann, K., & Mehrdana, F. (2016). Effects of anisakid nematodes Anisakis simplex (s.l.), Pseudoterranova decipiens (s.l.) and Contracaecum osculatum (s.l.) on fish and consumer health. Food and Waterborne Parasitology, 4, 13-22. https://doi.org/10.1016/j.fawpar.2016.07.003 + + + Casini, M., Käll, F., Hansson, M., Plikshs, M., Baranova, T., Karlsson, O., Lundström, K., Neuenfeldt, S., Gårdmark, A., & Hjelm, J. (2016). Hypoxic areas, density-dependence and food limitation drive the body condition of a heavily exploited marine fish predator. Royal Society Open Science, 3(10), 160416. https://doi.org/10.1098/rsos.160416 + + + Chandra, R. K. (1997). Nutrition and the immune system: An introduction. The American Journal of Clinical Nutrition, 66, 460S-463S. + + + Cornick, J. W., Morrison, C. M., Zwicker, B., & Shum, G. (1984). Atypical Aeromonas salmonicida infection in Atlantic cod, Gadus morhua L. Journal of Fish Diseases, 6(7), 495-499. + + + Dutil, J. D., Godbout, G., Blier, P. U., & Groman, D. (2006). The effect of energetic condition on growth dynamics and health of Atlantic cod (Gadus morhua). Journal of Applied Ichthyology, 22(2), 138-144. + + + Eero, M., Hjelm, J., Behrens, J., Buchmann, K., Cardinale, M., Casini, M., Gasyukov, P., Holmgren, N., Horbowy, J., Hussy, K., Kirkegaard, E., Kornilovs, G., Krumme, U., Koster, F. W., Oeberst, R., Plikshs, M., Radtke, K., Raid, T., Schmidt, J., … Storr-Paulsen, M. (2015). Eastern Baltic cod in distress: Biological changes and challenges for stock assessment. ICES Journal of Marine Science, 72(8), 2180-2186. https://doi.org/10.1093/icesjms/fsv109 + + + Elarifi, A. E. (1982). The histopathology of larval anisakid nematode infections in the liver of whiting, Merlangius merlangus (L.), with some observations on blood leucocytes of the fish. Journal of Fish Diseases, 5(5), 411-419. + + + Fagerholm, H. P. (1982). Parasites of fish in Finland. VI. Nematodes. Acta Academiae Aboensis, B, 40, 1-128. + + + Feist, S. W., & Longshaw, M. (2008). Histopathology of fish parasite infections-importance for populations. Journal of Fish Biology, 73(9), 2143-2160. + + + Galindo, G. M., Rodrigues, R. A., Marcondes, S. F., Soares, P., Tavares, L. E. R., & Fernandes, C. E. (2017). Morphological and morphometric features of nematode-cysts in Gymnotus inaequilabiatus liver in the Brazilian Pantanal. Revista Brasileira de Parasitologia Veterinária, 26, 285-291. + + + Gulland, F. M. D. (1992). The role of nematode parasites in Soay sheep (Ovis aries L.) mortality during a population crash. Parasitology, 105(3), 493-503. + + + Haarder, S., Kania, P. W., Galatius, A., & Buchmann, K. (2014). Increased Contracaecum Osculatum infection in Baltic cod (Gadus Morhua) livers (1982-2012) associated with increasing grey seal (Halichoerus Gryphus) populations. Journal of Wildlife Diseases, 50(3), 537-543. https://doi.org/10.7589/2012-12-320 + + + Harding, K. C., Härkönen, T., Helander, B., & Karlsson, O. (2007). Status of Baltic grey seals: Population assessment and extinction risk. NAMMCO Scientific Publications, 6, 33. https://doi.org/10.7557/3.2720 + + + Hauksson, E. (2011). The prevalence, abundance, and density of Pseudoterranova sp. (p) Larvae in the flesh of cod (Gadus morhua) relative to proximity of grey seal (Halichoerus grypus) colonies on the coast off Drangar, Northwest Iceland. Journal of Marine Biology, 2011, 235832. https://doi.org/10.1155/2011/235832 + + + HELCOM. (2018). Population trends and abundance of seals (issue July). + + + Hemmingsen, W., & Mackenzie, K. (2001). The parasite fauna of the Atlantic cod (Gadus morhua L.). Advances in Marine Biology, 40, 2-60. + + + Herreras, M. V., Balbuena, J. A., Aznar, F. J., Kaarstad, S. E., Fernández, M., & Raga, J. A. (2004). Population structure of Anisakis simplex (Nematoda) in harbor porpoises Phocoena phocoena off Denmark. Journal of Parasitology, 90(5), 933-938. + + + Horbowy, J., Podolska, M., & Nadolna-Ałtyn, K. (2016). Increasing occurrence of anisakid nematodes in the liver of cod (Gadus morhua) from the Baltic Sea: Does infection affect the condition and mortality of fish? Fishery Research, 179, 98-103. + + + ICES. (2020). Working group on marine mammal ecology (WGMME). ICES Scientific Reports, 2, 39. https://doi.org/10.17895/ices.pub.5975 + + + Johansen, M. V., Bøgh, H. O., Giver, H., Eriksen, L., Nansen, P., Stephenson, L., & Knudsen, K. E. B. (1997). Schistosoma japonicum and Trichuris suis infections in pigs fed diets with high and low protein. Parasitology, 115(3), 257-264. + + + Køie, M., & Fagerholm, H.-P. (1995). The life cycle of Contracaecum osculatum (Rudolphi, 1802) sensu stricto. Parasitology Reseserach, 81, 481-489. + + + Lambert, Y., & Dutil, J. D. (2000). Energetic consequences of reproduction in Atlantic cod (Gadus morhua) in relation to spawning level of somatic energy reserves. Canadian Journal of Fisheries and Aquatic Sciences, 57(4), 815-825. + + + MacKinnon, B. M. (1998). Host factors important in sea lice infections. ICES Journal of Marine Science, 55(2), 188-192. + + + Marnis, H., Kania, P. W., Syahputra, K., Zuo, S., & Buchmann, K. (2020). Local immune depression in Baltic cod (Gadus morhua) liver infected with Contracaecum osculatum. Journal of Helminthology, 94, e112. https://doi.org/10.1017/S0022149X19001111 + + + Mohamed, A., Zuo, S., Karami, A. M., Marnis, H., Setyawan, A., Mehrdana, F., Kirkeby, C., Kania, P., & Buchmann, K. (2020). Contracaecum osculatum (sensu lato) infection of Gadus morhua in the Baltic Sea: Inter- and intraspecific interactions. International Journal for Parasitology, 50(10-11), 891-898. https://doi.org/10.1016/j.ijpara.2020.06.003 + + + Nadolna, K., & Podolska, M. (2014). Anisakid larvae in the liver of cod (Gadus morhua) L. from the southern Baltic Sea. Journal of Helminthology, 88(2), 237-246. https://doi.org/10.1017/s0022149x13000096 + + + Neuenfeldt, S., Bartolino, V., Orio, A., Andersen, K. H., Ustups, D., Kulatska, N., Andersen, N. G., Niiranen, S., Bergstro, U., & Casini, M. (2020). Feeding and growth of Atlantic cod (Gadus morhua L.) in the eastern Baltic Sea under environmental change. ICES Journal of Marine Science, 77, 624-632. https://doi.org/10.1093/icesjms/fsz224 + + + Oliva-Teles, A. (2012). Nutrition and health of aquaculture fish. Journal of Fish Diseases, 35(2), 83-108. + + + Olsen, A. B., Mikalsen, J., Rode, M., Alfjorden, A., Hoel, E., Straum-Lie, K., Haldorsen, R., & Colquhoun, D. J. (2006). A novel systemic granulomatous inflammatory disease in farmed Atlantic cod, Gadus morhua L., associated with a bacterium belonging to the genus Francisella. Journal of Fish Diseases, 29(5), 307-311. + + + Petrushevski, G. K., & Shulman, G. G. (1955). Infection of Baltic cod liver with roundworms. Trudy Akademii Nauk Litovskoi SSR. Seriia B, 2, 119-125. + + + R Core Team. (2016). R: A language and environment for statistical computing. R Foundation for Statistical Computing. + + + Roberts, R. J., & Ellis, A. E. (2012). The anatomy and physiology of teleosts. In R. J. Roberts (Ed.), Fish pathology (4th ed., pp. 17-62). Wiley-Blackwell. + + + Ryberg, M. P. (2020). Eastern Baltic cod infected with Contracaecum osculatum: Physiological mechanisms and the importance of monitoring infection loads. PhD thesis, DTU Aqua. + + + Ryberg, M. P., Huwer, B., Nielsen, A., Dierking, J., Buchmann, K., Sokolova, M., Krumme, U., & Behrens, J. W. (2022). Parasite load of Atlantic cod Gadus morhua in the Baltic Sea assessed by the liver category method, and associations with infection density and critical condition. Fisheries Management and Ecology, 29(1), 88-99. + + + Ryberg, M. P., Skov, P. V., Vendramin, N., Buchmann, K., Nielsen, A., & Behrens, J. W. (2020). Physiological condition of eastern Baltic cod, Gadus morhua, infected with the parasitic nematode Contracaecum osculatum. Conservation Physiology, 8(1), coaa093. https://doi.org/10.1093/conphys/coaa093 + + + Salomoni, C., Fiorentino, M., & Palenzona, D. L. (1987). Effects of diet, sham-immunization and bleeding on the immune response kinetics for two strains of Cyprinus carpio. Journal of Fish Biology, 31, 93-99. + + + Sayyaf Dezfuli, B., Fernandes, C. E., Galindo, G. M., Castaldelli, G., Manera, M., DePasquale, J. A., Lorenzoni, M., Bertin, S., & Giari, L. (2016). Nematode infection in liver of the fish Gymnotus inaequilabiatus (Gymnotiformes: Gymnotidae) from the Pantanal Region in Brazil: pathobiology and inflammatory response. Parasites and vectors, 9(1), 473. + + + Setyawan, A. C., Jensen, H. M., Kania, P. W., & Buchmann, K. (2020). Baltic cod endohelminths reflect recent ecological changes. Journal of Helminthology, 94, e155. + + + Sokolova, M., Buchmann, K., Huwer, B., Kania, P. W., Krumme, U., Galatius, A., Hemmer-Hansen, J., & Behrens, J. W. (2018). Spatial patterns in infection of cod Gadus morhua with the seal-associated liver worm Contracaecum osculatum from the Skagerrak to the Central Baltic Sea. Marine Ecology Progress Series, 606, 105-118. https://doi.org/10.3354/meps12773 + + + Star, B., Nederbragt, A. J., Jentoft, S., Grimholt, U., Malmstrøm, M., Gregers, T. F., Rounge, T. B., Paulsen, J., Solbakken, M. H., Sharma, A., Wetten, O. F., Lanzén, A., Winer, R., Knight, J., Vogel, J.-H., Aken, B., Andersen, Ø., Lagesen, K., Tooming-Klunderud, A., … Jakobsen, K. S. (2011). The genome sequence of Atlantic cod reveals a unique immune system. Nature, 477(7363), 207-210. + + + Wang, X., Copmans, D., & de Witte, P. A. (2021). Using zebrafish as a disease model to study fibrotic disease. International Journal of Molecular Sciences, 22(12), 6404. + + + Zuo, S., Barlaup, L., Mohammadkarami, A., Al-Jubury, A., Chen, D., Kania, P. W., & Buchmann, K. (2017). Extrusion of Contracaecum osculatum nematode larvae from the liver of cod (Gadus morhua). Parasitology Research, 116(10), 1-6. https://doi.org/10.1007/s00436-017-5580-1 + + + Zuo, S., Huwer, B., Bahlool, Q., Al-Jubury, A., Christensen, N. D., Korbut, R., Kania, P., & Buchmann, K. (2016). Host size-dependent anisakid infection in Baltic cod Gadus morhua associated with differential food preferences. Diseases of Aquatic Organisms, 120(1), 69-75. + + + Zuo, S., Kania, P. W., Mehrdana, F., Marana, M. H., & Buchmann, K. (2018). Contracaecum osculatum and other anisakid nematodes in grey seals and cod in the Baltic Sea: Molecular and ecological links. Journal of Helminthology, 92(1), 81-89. + + + +
+ + + 36917513 + + 2023 + 03 + 14 + +
+ + 1520-5207 + + + 2023 + Mar + 14 + + + The journal of physical chemistry. B + J Phys Chem B + + Impact of the Force Field on the Calculation of Density and Surface Tension of Epoxy-Resins. + 10.1021/acs.jpcb.2c09087 + + The molecular simulation of interfacial systems is a matter of debate because of the choice of many input parameters that can affect significantly the performance of the force field of reproducing the surface tension and the coexisting densities. After developing a robust methodology for the calculation of the surface tension on a Lennard-Jones fluid, we apply it with different force fields to calculate the density and surface tension of pure constituents of epoxy resins. By using the model that best reproduces the experimental density and surface tension, we investigate the impact of composition in mass fraction on uncured epoxy resins and the effects of degree of cross-linking on cured resins. + + + + Orselly + Mathilde + M + + Specific Polymers, 150 Avenue des Cocardières, 34160 Castries, France. + + + + Richard + Cécile + C + + Specific Polymers, 150 Avenue des Cocardières, 34160 Castries, France. + + + + Devémy + Julien + J + + Université Clermont Auvergne, CNRS, Clermont Auvergne INP, Institut de Chimie de Clermont-Ferrand, F-63000 Clermont-Ferrand, France. + + + + Bouvet-Marchand + Agathe + A + 0000-0003-0371-1126 + + Specific Polymers, 150 Avenue des Cocardières, 34160 Castries, France. + + + + Dequidt + Alain + A + 0000-0003-1206-1911 + + Université Clermont Auvergne, CNRS, Clermont Auvergne INP, Institut de Chimie de Clermont-Ferrand, F-63000 Clermont-Ferrand, France. + + + + Loubat + Cédric + C + + Specific Polymers, 150 Avenue des Cocardières, 34160 Castries, France. + + + + Malfreyt + Patrice + P + 0000-0002-3710-5418 + + Université Clermont Auvergne, CNRS, Clermont Auvergne INP, Institut de Chimie de Clermont-Ferrand, F-63000 Clermont-Ferrand, France. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + J Phys Chem B + 101157530 + 1520-5207 + + IM +
+ + + + 2023 + 3 + 14 + 13 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917513 + 10.1021/acs.jpcb.2c09087 + + +
+ + + 36917498 + + 2023 + 03 + 14 + +
+ + 1944-8252 + + + 2023 + Mar + 14 + + + ACS applied materials & interfaces + ACS Appl Mater Interfaces + + Cicada-Wing-Inspired Highly Sensitive Tactile Sensors Based on Elastic Carbon Foam with Nanotextured Surfaces. + 10.1021/acsami.2c22204 + + Electronic devices with tactile and pressure-sensing capabilities are becoming increasingly popular in the automatic industry, human motion/health monitoring, and artificial intelligence applications. Inspired by the natural nanotopography of the cicada wing, we propose here a straightforward strategy to fabricate a highly sensitive tactile sensor through nanotexturing of erected polyaniline (PANI) nanoneedles on a conductive and elastic three-dimensional (3D) carbon skeleton. The robust and compressible carbon networks offer a resilient and conducting matrix to catering complex scenarios; the biomimetic PANI nanoneedles firmly and densely anchored on a 3D carbon skeleton provide intimate electrical contact under subtle deformation. As a result, a piezoresistive tactile sensor with ultrahigh sensitivity (33.52 kPa-1), fast response/recovery abilities (97/111 ms), and reproducible sensing performance (2500 cycles) is developed, which is capable of distinguishing motions in a wide pressure range from 4.66 Pa to 60 kPa, detecting spatial pressure distribution, and monitoring various gestures in a wireless manner. These excellent performances demonstrate the great potential of nature-inspired tactile sensors for practical human motion monitoring and artificial intelligence applications. + + + + Chang + Kangqi + K + + Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China. + + + + Wu + Zhenzhong + Z + + Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China. + + + + Meng + Jian + J + + Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China. + + + + Guo + Minhao + M + + Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China. + + + + Yan + Xiu-Ping + XP + + School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. + + + + Qian + Hai-Long + HL + 0000-0001-7554-4115 + + School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. + + + + Ma + Piming + P + 0000-0002-4597-0639 + + Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China. + + + + Zhao + Jianhua + J + + Jiangsu Huaxicun Co. Ltd., Jiangyin, 214420, China. + + + + Wang + Fangneng + F + + Jiangsu Huaxicun Co. Ltd., Jiangyin, 214420, China. + + + + Huang + Yunpeng + Y + 0000-0002-8710-9062 + + Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China. + + + + Liu + Tianxi + T + + Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + ACS Appl Mater Interfaces + 101504991 + 1944-8244 + + IM + + biomimetic nanostructures + elastic carbon foams + human motion detection + polyaniline + tactile sensors + +
+ + + + 2023 + 3 + 14 + 12 + 53 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917498 + 10.1021/acsami.2c22204 + + +
+ + + 36917503 + + 2023 + 03 + 14 + +
+ + 1520-5207 + + + 2023 + Mar + 14 + + + The journal of physical chemistry. B + J Phys Chem B + + Protonation of Strained Epoxy Resin under Wet Conditions via First-Principles Calculations Using the H+-Shift Method. + 10.1021/acs.jpcb.3c00401 + + A significant challenge in adhesive bonding is the accelerated breaking of stretched adhesives under wet conditions, which is known as cohesive failure. One group of commonly used adhesives consists of the amine-cured epoxy resins. Based on deprotonation free-energy calculations of the unstrained resin in water, it has recently been proposed that these adhesives can undergo failure through breakage originating at the protonated amine group under neutral or acidic conditions [J. Phys. Chem. B 2021, 125, 8989-8996]. In this study, we comprehensively investigated the degree of protonation of the amine group under both stretched and compressed conditions by devising a robust first-principles protonation calculation method applicable to strained materials. It was found that the amine group was partially protonated in neutral water at 298 K and that the amine group was protonated when the epoxy resin was stretched to a greater extent in water, and vice versa. These findings support the physicochemical cause of cohesive failure due to protonation of the amine group in the stretched amine-cured epoxy resins. + + + + Ogata + Shuji + S + 0000-0002-5396-5864 + + Graduate School of Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555, Japan. + + + + Uranagase + Masayuki + M + + Graduate School of Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555, Japan. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + J Phys Chem B + 101157530 + 1520-5207 + + IM +
+ + + + 2023 + 3 + 14 + 13 + 2 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917503 + 10.1021/acs.jpcb.3c00401 + + +
+ + + 36917504 + + 2023 + 03 + 14 + +
+ + 1520-5207 + + + 2023 + Mar + 14 + + + The journal of physical chemistry. B + J Phys Chem B + + Molecular Orientation of Carboxylate Anions at the Water-Air Interface Studied with Heterodyne-Detected Vibrational Sum-Frequency Generation. + 10.1021/acs.jpcb.2c08992 + + The carboxylate anion group plays an important role in many (bio)chemical systems and polymeric materials. In this work, we study the orientation of carboxylate anions with various aliphatic and aromatic substituents at the water-air interface by probing the carboxylate stretch vibrations with heterodyne-detected vibrational sum-frequency generation spectroscopy in different polarization configurations. We find that carboxylate groups with small aliphatic substituents show a large tilt angle with respect to the surface normal and that this angle decreases with increasing size of the substituent. We further use the information about the orientation of the carboxylate group to determine the hyperpolarizability components of this group. + + + + Korotkevich + Alexander A + AA + 0000-0002-0775-752X + + Ultrafast Spectroscopy, AMOLF, Science Park 104, Amsterdam 1098XG, Netherlands. + + + + Moll + Carolyn J + CJ + 0000-0001-6041-5898 + + Ultrafast Spectroscopy, AMOLF, Science Park 104, Amsterdam 1098XG, Netherlands. + + + + Versluis + Jan + J + + Ultrafast Spectroscopy, AMOLF, Science Park 104, Amsterdam 1098XG, Netherlands. + + + + Bakker + Huib J + HJ + 0000-0003-1564-5314 + + Ultrafast Spectroscopy, AMOLF, Science Park 104, Amsterdam 1098XG, Netherlands. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + J Phys Chem B + 101157530 + 1520-5207 + + IM +
+ + + + 2023 + 3 + 14 + 13 + 2 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917504 + 10.1021/acs.jpcb.2c08992 + + +
+ + + 36917505 + + 2023 + 03 + 14 + +
+ + 1536-0237 + + + 2023 + Feb + 28 + + + Journal of thoracic imaging + J Thorac Imaging + + Cardiac Magnetic Resonance Imaging T1 and T2 Mapping in Systemic Lupus Erythematosus in Relation to Antimalarial Treatment. + 10.1097/RTI.0000000000000703 + + Patients with systemic lupus erythematosus (SLE) are at risk of cardiac disease including antimalarial-induced cardiomyopathy (AMIC). The purpose of this study is to evaluate cardiac magnetic resonance imaging parametric mapping findings in SLE patients with AMIC and investigate the relationship of T1/T2 mapping to antimalarial (AM) treatment duration. + All patients with SLE who had undergone cardiac magnetic resonance imaging with T1/T2 mapping for evaluation of suspected cardiac disease between 2018 and 2021 were evaluated and compared with healthy controls. To facilitate comparison between scanners, T1/T2 values were converted to a z-score using scanner-specific local reference values. Patients were classified into 3 groups: AMIC, myocarditis, and other (no AMIC or myocarditis). + Forty-five SLE patients (47±17 y, 80% female; 8 [18%] with AMIC and 7 [16%] with myocarditis) and 30 healthy controls (39±15 y, 60% female) were included. Patients with AMIC had higher T1 and T2 compared with controls (z-score 1.1±1.3 vs. 0±0.6, P=0.01 and 1.7±1.1 vs. 0±1.0, P<0.01, respectively) and lower values compared with those with myocarditis (3.7±1.6, P<0.01 and 4.0±2.0, P<0.01, respectively). T1 correlated negatively with AM treatment duration in patients without AMIC or myocarditis (r=-0.36, P=0.048) and positively in patients with AMIC (r=0.92, P=0.001). AM treatment duration did not correlate significantly with T1 in patients with myocarditis or with T2 in any group. + The relationship between T1 and AM treatment duration differed between groups. Native T1 decreases with longer treatment in patients without AMIC or myocarditis, possibility due to glycosphingolipid accumulation. In patients with AMIC, increasing T1 with longer treatment could reflect fibrosis. + Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved. + + + + Shalmon + Tamar + T + + University Medical Imaging Toronto, Department of Medical Imaging, University of Toronto. + + + Department of Radiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. + + + + Thavendiranathan + Paaladinesh + P + + University Medical Imaging Toronto, Department of Medical Imaging, University of Toronto. + + + Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, University of Toronto. + + + + Seidman + Michael A + MA + + Laboratory Medicine Program, University Health Network. + + + + Wald + Rachel M + RM + + University Medical Imaging Toronto, Department of Medical Imaging, University of Toronto. + + + Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, University of Toronto. + + + + Karur + Gauri Rani + GR + + University Medical Imaging Toronto, Department of Medical Imaging, University of Toronto. + + + Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, University of Toronto. + + + + Harvey + Paula J + PJ + + Division of Cardiology, Department of Medicine, Women's College Hospital, University of Toronto. + + + + Akhtari + Shadi + S + + Division of Cardiology, Department of Medicine, Women's College Hospital, University of Toronto. + + + + Osuntokun + Tosin + T + + Division of Cardiology, Department of Medicine, Women's College Hospital, University of Toronto. + + + + Tselios + Kostantinos + K + + University of Toronto Lupus Clinic, Toronto Western Hospital, Centre for Prognosis Studies in the Rheumatic Diseases, University Health Network, University of Toronto, Toronto, ON, Canada. + + + + Gladman + Dafna D + DD + + University of Toronto Lupus Clinic, Toronto Western Hospital, Centre for Prognosis Studies in the Rheumatic Diseases, University Health Network, University of Toronto, Toronto, ON, Canada. + + + + Hanneman + Kate + K + 0000-0002-3077-2218 + + University Medical Imaging Toronto, Department of Medical Imaging, University of Toronto. + + + Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, University of Toronto. + + + + eng + + Journal Article + + + 2023 + 02 + 28 + +
+ + United States + J Thorac Imaging + 8606160 + 0883-5993 + + IM + The authors declare no conflicts of interest. +
+ + + + 2023 + 3 + 14 + 13 + 2 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917505 + 10.1097/RTI.0000000000000703 + 00005382-990000000-00056 + + + + Dima A, Jurcut C, Chasset F, et al. Hydroxychloroquine in systemic lupus erythematosus: overview of current knowledge. Ther Adv Musculoskelet Dis. 2022;14:1759720X211073001. + + + Bertsias G, Ioannidis JPA, Boletis J, et al. EULAR recommendations for the management of systemic lupus erythematosus. Report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics. Ann Rheum Dis. 2008;67:195–205. + + + Petitdemange A, Felten R, Sibilia J, et al. Prescription strategy of antimalarials in cutaneous and systemic lupus erythematosus: an international survey. Ther Adv Musculoskelet Dis. 2021;13:1759720X211002595. + + + Chatre C, Roubille F, Vernhet H, et al. Cardiac complications attributed to chloroquine and hydroxychloroquine: a systematic review of the literature. Drug Safety. 2018;41:919–931. + + + Teixeira RA, Filho MM, Benvenuti LA, et al. Cardiac damage from chronic use of chloroquine: a case report and review of the literature. Arq Bras Cardiol. 2002;79:85–88. + + + Tönnesmann E, Stroehmann I, Kandolf R, et al. Cardiomyopathy caused by longterm treatment with chloroquine: a rare disease, or a rare diagnosis? J Rheumatol. 2012;39:1099–1103. + + + Tselios K, Deeb M, Gladman DD, et al. Antimalarial-induced cardiomyopathy: a systematic review of the literature. Lupus. 2018;27:591–599. + + + Frustaci A, Morgante E, Antuzzi D, et al. Inhibition of cardiomyocyte lysosomal activity in hydroxychloroquine cardiomyopathy. Int J Cardiol. 2012;157:117–119. + + + Karur GR, Mathur S, Morel CF, et al. Increased spread of native T1 assessed by MRI is a marker of cardiac involvement in fabry disease. Am J Roentgenol. 2020;216:355–361. + + + Augusto JB, Nordin S, Kozor R, et al. Inflammatory cardiomyopathy in fabry disease. Heart. 2019;105(suppl 3):A1. + + + Moon JC, Sheppard M, Reed E, et al. The histological basis of late gadolinium enhancement cardiovascular magnetic resonance in a patient with Anderson-Fabry disease. J Cardiovasc Magn Reson. 2006;8:479–482. + + + Joyce E, Fabre A, Mahon N. Hydroxychloroquine cardiotoxicity presenting as a rapidly evolving biventricular cardiomyopathy: key diagnostic features and literature review. Eur Heart J Acute Cardiovasc Care. 2013;2:77–83. + + + Shalmon T, Thavendiranathan P, Harvey P, et al. Cardiac MRI and clinical follow-up in antimalarial induced cardiomyopathy in patients with systemic lupus erythematosus. J Thorac Imaging. 2023. doi: 10.1097/RTI.0000000000000694. [Epub ahead of print]. + + 10.1097/RTI.0000000000000694 + + + + Tijmes FS, Thavendiranathan P, Udell JA, et al. Cardiac MRI assessment of nonischemic myocardial inflammation: state of the art review and update on myocarditis associated with COVID-19 vaccination. Radiol Cardiothorac Imaging. 2021;3:e210252. + + + Caredda G, Bassareo PP, Cau R, et al. Emerging role of cardiac magnetic resonance imaging in diagnosing myocarditis. J Thorac Imag. 2022;37:W12–W27. + + + Bordonaro V, Larici AR, Franchi P, et al. Imaging of cardiopulmonary involvement in systemic immune-mediated diseases. J Thorac Imag. 2021;36:W35–W51. + + + Hanneman K, Alberdi HV, Karur GR, et al. Antimalarial-induced cardiomyopathy resembles fabry disease on cardiac MRI. JACC Cardiovasc Imaging. 2020;13:879–881. + + + Karur GR, Robison S, Iwanochko RM, et al. Use of myocardial T1 mapping at 3.0 T to differentiate anderson-fabry disease from hypertrophic cardiomyopathy. Radiology. 2018;288:172613. + + + Warnica W, Al-Arnawoot A, Stanimirovic A, et al. Clinical impact of cardiac MRI T1 and T2 parametric mapping in patients with suspected cardiomyopathy. Radiology. 2022;305:319–326. + + + Hanneman K. Myocardial imaging with CMR parametric mapping: clinical applications. Curr Radiol Rep. 2018;6:47. + + + Muscogiuri G, Suranyi P, Schoepf UJ, et al. Cardiac magnetic resonance T1-mapping of the myocardium: technical background and clinical relevance. J Thorac Imaging. 2018;33:71–80. + + + Muthukrishnan P, Roukoz H, Grafton G, et al. Hydroxychloroquine-induced cardiomyopathy: a case report. Circ Heart Fail. 2011;4:e7–e8. + + + Caforio ALP, Pankuweit S, Arbustini E, et al. Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur Heart J. 2013;34:2636–2648; 2648a–2648d. + + + Ferreira VM, Schulz-Menger J, Holmvang G, et al. Cardiovascular magnetic resonance in nonischemic myocardial inflammation: expert recommendations. J Am Coll Cardiol. 2018;72:3158–3176. + + + Gladman DD, Ibanez D, Urowitz MB. Systemic lupus erythematosus disease activity index 2000. J Rheumatol. 2002;29:288–291. + + + Bruce IN, O’Keeffe AG, Farewell V, et al. Factors associated with damage accrual in patients with systemic lupus erythematosus: results from the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort. Ann Rheum Dis. 2015;74:1706–1713. + + + Fronza M, Thavendiranathan P, Karur GR, et al. Cardiac MRI and clinical follow-up in COVID-19 vaccine–associated myocarditis. Radiology. 2022;304:E48–E49. + + + Fronza M, Thavendiranathan P, Chan V, et al. Myocardial injury pattern at MRI in COVID-19 vaccine–associated myocarditis. Radiology. 2022;304:553–562. + + + Puntmann VO, D’Cruz D, Smith Z, et al. Native myocardial T1 mapping by cardiovascular magnetic resonance imaging in subclinical cardiomyopathy in patients with systemic lupus erythematosus. Circ Cardiovasc Imaging. 2013;6:295–301. + + + Hinojar R, Foote L, Sangle S, et al. Native T1 and T2 mapping by CMR in lupus myocarditis: disease recognition and response to treatment. Int J Cardiol. 2016;222:717–726. + + + Thompson RB, Chow K, Khan A, et al. T(1) mapping with cardiovascular MRI is highly sensitive for Fabry disease independent of hypertrophy and sex. Circ Cardiovasc Imaging. 2013;6:637–645. + + + Hanneman K, Karur GR, Wasim S, et al. Left ventricular hypertrophy and late gadolinium enhancement at cardiac MRI are associated with adverse cardiac events in Fabry disease. Radiology. 2020;294:42–49. + + + Roos JM, Aubry M-C, Edwards WD. Chloroquine cardiotoxicity: clinicopathologic features in three patients and comparison with three patients with Fabry disease. Cardiovasc Pathol. 2002;11:277–283. + + + Deva DP, Hanneman K, Li Q, et al. Cardiovascular magnetic resonance demonstration of the spectrum of morphological phenotypes and patterns of myocardial scarring in Anderson-Fabry disease. J Cardiovasc Magn Resonance. 2016;18:14. + + + Tselios K, Deeb M, Gladman DD, et al. Antimalarial-induced cardiomyopathy in systemic lupus erythematosus: as rare as considered? J Rheumatol. 2019;46:391–396. + + + Tett SE. Clinical pharmacokinetics of slow-acting antirheumatic drugs. Clin Pharmacokinet. 1993;25:392–407. + + + Sanchez-Nino MD, Carpio D, Sanz AB, et al. Lyso-Gb3 activates Notch1 in human podocytes. Hum Mol Genet. 2015;24:5720–5732. + + + Hanneman K, Karur GR, Wasim S, et al. Prognostic significance of cardiac magnetic resonance imaging late gadolinium enhancement in Fabry disease. Circulation. 2018;138:2579–2581. + + + +
+ + + 36917511 + + 2023 + 03 + 14 + +
+ + 1945-7103 + + + 2023 + Mar + 14 + + + The Angle orthodontist + Angle Orthod + + The accuracy of artificial intelligence-based virtual assistants in responding to routinely asked questions about orthodontics. + 10.2319/100922-691.1 + + To evaluate the utility and efficiency of four voice-activated, artificial intelligence-based virtual assistants (Alexa, Google Assistant, Siri, and Cortana) in addressing commonly asked patient questions in orthodontic offices. + Two orthodontists, an orthodontic resident, an oral and maxillofacial radiologist, and a dental student used a standardized list of 12 questions to query and evaluate the four most common commercial virtual assistant devices. A modified Likert scale was used to evaluate their performance. + Google Assistant had the lowest (best) mean score, followed by Siri, Alexa, and Cortana. The score of Google Assistant was significantly lower than Alexa and Cortana. There was significant variablity in virtual assistant response scores among the evaluators, with the exception of Amazon Alexa. Lower scores indicated superior efficiency and utility. + The common commercially available virtual assistants tested in this study showed significant differences in how they responded to users. There were also significant differences in their performance when responding to common orthodontic queries. An intelligent virtual assistant with evidence-based responses specifically curated for orthodontics may be a good solution to address this issue. The investigators in this study agreed that such a device would provide value to patients and clinicians. + © 0000 by The EH Angle Education and Research Foundation, Inc. + + + + Perez-Pino + Anthony + A + + + Yadav + Sumit + S + + + Upadhyay + Madhur + M + + + Cardarelli + Lauren + L + + + Tadinada + Aditya + A + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Angle Orthod + 0370550 + 0003-3219 + + IM + + Artificial intelligence + Virtual assistants + +
+ + + + 2023 + 02 + 01 + + + 2022 + 10 + 01 + + + 2023 + 3 + 14 + 13 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917511 + 491419 + 10.2319/100922-691.1 + + +
+ + + 36917506 + + 2023 + 03 + 14 + +
+ + 1536-0237 + + + 2023 + Mar + 06 + + + Journal of thoracic imaging + J Thorac Imaging + + Opportunistic Screening for Atrial Fibrillation on Routine Chest Computed Tomography. + 10.1097/RTI.0000000000000702 + + Quantitative biomarkers from chest computed tomography (CT) can facilitate the incidental detection of important diseases. Atrial fibrillation (AFib) substantially increases the risk for comorbid conditions including stroke. This study investigated the relationship between AFib status and left atrial enlargement (LAE) on CT. + A total of 500 consecutive patients who had undergone nongated chest CTs were included, and left atrium maximal axial cross-sectional area (LA-MACSA), left atrium anterior-posterior dimension (LA-AP), and vertebral body cross-sectional area (VB-Area) were measured. Height, weight, age, sex, and diagnosis of AFib were obtained from the medical record. Parametric statistical analyses and receiver operating characteristic curves were performed. Machine learning classifiers were run with clinical risk factors and LA measurements to predict patients with AFib. + Eighty-five patients with a diagnosis of AFib were identified. Mean LA-MACSA and LA-AP were significantly larger in patients with AFib than in patients without AFib (28.63 vs. 20.53 cm2, P<0.000001; 4.34 vs. 3.5 cm, P<0.000001, respectively), both with area under the curves (AUCs) of 0.73. Multivariable logistic regression analysis including age, sex, and VB-Area with LA-MACSA improved the AUC for predicting AFib (AUC=0.77). An LA-MACSA threshold of 30 cm2 demonstrated high specificity for AFib diagnosis at 92% and sensitivity of 48%, and LA-AP threshold at 4.5 cm demonstrated 90% specificity and 42% sensitivity. A Bayesian machine learning model using age, sex, height, body surface area, and LA-MACSA predicted AFib with an AUC of 0.743. + LA-MACSA or LA-AP can be rapidly measured from routine chest CT, and when >30 cm2 and >4.5 cm, respectively, are specific indicators to predict patients at increased risk for AFib. + Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved. + + + + Parker + William A + WA + 0000-0003-1704-8716 + + Stanford University School of Medicine, Stanford, CA. + + + + Vigneault + Davis M + DM + + Stanford University School of Medicine, Stanford, CA. + + + + Yang + Issac + I + + Stanford University School of Medicine, Stanford, CA. + + + + Bratt + Alex + A + + Stanford and Mayo Clinic Hospital, Rochester, MN. + + + + Marquardt + Alizee C + AC + + Stanford University School of Medicine, Stanford, CA. + + + + Sharifi + Husham + H + + Stanford University School of Medicine, Stanford, CA. + + + + Guo + Haiwei Henry + HH + + Stanford University School of Medicine, Stanford, CA. + + + + eng + + Journal Article + + + 2023 + 03 + 06 + +
+ + United States + J Thorac Imaging + 8606160 + 0883-5993 + + IM + The authors declare no conflicts of interest. +
+ + + + 2023 + 3 + 14 + 13 + 2 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917506 + 10.1097/RTI.0000000000000702 + 00005382-990000000-00057 + + + + Murray CJL, Mokdad AH, Ballestros K, et al. The state of US health, 1990-2016: burden of diseases, injuries, and risk factors among US states. JAMA. 2018;319:1444–1472. + + + Arboix A, Alioc J. Cardioembolic stroke: clinical features, specific cardiac disorders and prognosis. Curr Cardiol Rev. 2010;6:150. + + + Tsang TSM, Barnes ME, Bailey KR, et al. Left atrial volume: important risk marker of incident atrial fibrillation in 1655 older men and women. Mayo Clin Proc. 2001;76:467–475. + + + Vaziri SM, Larson MG, Benjamin EJ, et al. Echocardiographic predictors of nonrheumatic atrial fibrillation. The Framingham Heart Study. Circulation. 1994;89:724–730. + + + Hota P, Simpson S. Going beyond cardiomegaly: evaluation of cardiac chamber enlargement at non-electrocardiographically gated multidetector CT: current techniques, limitations, and clinical implications. Radiol Cardiothorac Imaging. 2019;1:e180024. + + + Butt W, Dhillon PS, Lenthall R, et al. Left atrial enlargement on non-gated CT is associated with large vessel occlusion in acute ischaemic stroke. Cerebrovasc Dis Extra. 2021;11:87–91. + + + Bratt A, Guenther Z, Hahn LD, et al. Left atrial volume as a biomarker of atrial fibrillation at routine chest CT: deep learning approach. Radiol Cardiothorac Imaging. 2019;1:e190057. + + + Kornej J, Börschel CS, Börschel CS, et al. Epidemiology of atrial fibrillation in the 21st century. Circ Res. 2020;127:4–20. + + + Jivraj K, Bedayat A, Sung YK, et al. Left atrium maximal axial cross-sectional area is a specific computed tomographic imaging biomarker of World Health Organization Group 2 pulmonary hypertension. J Thorac Imaging. 2017;32:121–126. + + + Cameli M, Incampo E, Mondillo S. Left atrial deformation: useful index for early detection of cardiac damage in chronic mitral regurgitation. Int J Cardiol Heart Vasc. 2017;17:17. + + + Mahabadi AA, Truong QA, Schlett CL, et al. Axial area and anteroposterior diameter as estimates of left atrial size using computed tomography of the chest: comparison with 3-dimensional volume. J Cardiovasc Comput Tomogr. 2010;4:49–54. + + + Eifer DA, Nguyen ET, Thavendiranathan P, et al. Diagnostic accuracy of sex-specific chest CT measurements compared with cardiac MRI findings in the assessment of cardiac chamber enlargement. AJR Am J Roentgenol. 2018;211:993–999. + + + Geraghty EM, Boone JM. Determination of height, weight, body mass index, and body surface area with a single abdominal CT image1. Radiology. 2003;228:857–863. + + + Sohrabi S, Hope M, Saloner D, et al. Left atrial transverse diameter on computed tomography angiography can accurately diagnose left atrial enlargement in patients with atrial fibrillation. J Thorac Imaging. 2015;30:214–217. + + + Aviram G, Rozenbaum Z, Ziv-Baran T, et al. Identification of pulmonary hypertension caused by left-sided heart disease (World Health Organization Group 2) based on cardiac chamber volumes derived from chest CT imaging. Chest. 2017;152:792–799. + + + Arbelo E, Bax JJ, Blomströ m-Lundqvist C, et al. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS) ESC Committee for Practice Guidelines (CPG) and National Cardiac Societies document reviewers, and Author/Task Force Member affiliations: listed in the Appendix. Eur Heart J. 2021;42:373–498. + + + January CT, Wann LS, Alpert JS, et al. 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society. J Am Coll Cardiol. 2014;64:e1–e76. + + + Davidson KW, Barry MJ, Mangione CM, et al. Screening for atrial fibrillation: US Preventive Services Task Force Recommendation Statement. JAMA. 2022;327:360–367. + + + Freedman B, Camm J, Calkins H, et al. Screening for atrial fibrillation: a report of the AF-SCREEN International Collaboration. Circulation. 2017;135:1851–1867. + + + Olshansky B, Chung M, Pogwizd S, et al. Arrhythmia Essentials. Elsevier; 2017;2:87–120. + + + Prystowsky EN, Padanilam BJ, Fogel RI. Treatment of atrial fibrillation. JAMA. 2015;314:278–288. + + + Montillet M, Baqué-Juston M, Tasu JP, et al. The left atrio-vertebral ratio: a new simple means for assessing left atrial enlargement on computed tomography. Eur Radiol. 2018;28:1310–1317. + + + Persson CE, Adiels M, Björck L, et al. Young women, body size and risk of atrial fibrillation. Eur J Prev Cardiol. 2018;25:173–180. + + + Andersen K, Rasmussen F, Neovius M, et al. Body size and risk of atrial fibrillation: a cohort study of 1.1 million young men. J Intern Med. 2018;283:346–355. + + + Lai FY, Nath M, Hamby SE, et al. Adult height and risk of 50 diseases: a combined epidemiological and genetic analysis. BMC Med. 2018;16:187. + + + Raghavan S, Huang J, Tcheandjieu C, et al. A multi-population phenome-wide association study of genetically-predicted height in the Million Veteran Program. PLoS Genet. 2022;18:e1010193. + + + +
+ + + 36917510 + + 2023 + 03 + 14 + +
+ + 1944-8252 + + + 2023 + Mar + 14 + + + ACS applied materials & interfaces + ACS Appl Mater Interfaces + + Chemical Modification of Human Decellularized Extracellular Matrix for Incorporation into Phototunable Hybrid-Hydrogel Models of Tissue Fibrosis. + 10.1021/acsami.2c18330 + + Tissue fibrosis remains a serious health condition with high morbidity and mortality rates. There is a critical need to engineer model systems that better recapitulate the spatial and temporal changes in the fibrotic extracellular microenvironment and enable study of the cellular and molecular alterations that occur during pathogenesis. Here, we present a process for chemically modifying human decellularized extracellular matrix (dECM) and incorporating it into a dynamically tunable hybrid-hydrogel system containing a poly(ethylene glycol)-α methacrylate (PEGαMA) backbone. Following modification and characterization, an off-stoichiometry thiol-ene Michael addition reaction resulted in hybrid-hydrogels with mechanical properties that could be tuned to recapitulate many healthy tissue types. Next, photoinitiated, free-radical homopolymerization of excess α-methacrylates increased crosslinking density and hybrid-hydrogel elastic modulus to mimic a fibrotic microenvironment. The incorporation of dECM into the PEGαMA hydrogel decreased the elastic modulus and, relative to fully synthetic hydrogels, increased the swelling ratio, the average molecular weight between crosslinks, and the mesh size of hybrid-hydrogel networks. These changes were proportional to the amount of dECM incorporated into the network. Dynamic stiffening increased the elastic modulus and decreased the swelling ratio, average molecular weight between crosslinks, and the mesh size of hybrid-hydrogels, as expected. Stiffening also activated human fibroblasts, as measured by increases in average cellular aspect ratio (1.59 ± 0.02 to 2.98 ± 0.20) and expression of α-smooth muscle actin (αSMA). Fibroblasts expressing αSMA increased from 25.8 to 49.1% upon dynamic stiffening, demonstrating that hybrid-hydrogels containing human dECM support investigation of dynamic mechanosensing. These results improve our understanding of the biomolecular networks formed within hybrid-hydrogels: this fully human phototunable hybrid-hydrogel system will enable researchers to control and decouple the biochemical changes that occur during fibrotic pathogenesis from the resulting increases in stiffness to study the dynamic cell-matrix interactions that perpetuate fibrotic diseases. + + + + Hewawasam + Rukshika S + RS + + Department of Bioengineering, University of Colorado, Denver|Anschutz Medical Campus, 2115 Scranton Street, Suite 3010, Aurora, Colorado 80045-2559, United States. + + + + Blomberg + Rachel + R + + Department of Bioengineering, University of Colorado, Denver|Anschutz Medical Campus, 2115 Scranton Street, Suite 3010, Aurora, Colorado 80045-2559, United States. + + + + Šerbedžija + Predrag + P + + Department of Bioengineering, University of Colorado, Denver|Anschutz Medical Campus, 2115 Scranton Street, Suite 3010, Aurora, Colorado 80045-2559, United States. + + + + Magin + Chelsea M + CM + 0000-0002-6988-8584 + + Department of Bioengineering, University of Colorado, Denver|Anschutz Medical Campus, 2115 Scranton Street, Suite 3010, Aurora, Colorado 80045-2559, United States. + + + Department of Pediatrics, University of Colorado, Anschutz Medical Campus, 2115 Scranton Street, Suite 3010, Aurora, Colorado 80045-2559, United States. + + + Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado, Anschutz Medical Campus, 2115 Scranton Street, Suite 3010, Aurora, Colorado 80045-2559, United States. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + ACS Appl Mater Interfaces + 101504991 + 1944-8244 + + IM + + biomaterial + decellularized extracellular matrix + fibroblast activation + fibrosis + hybrid-hydrogel + +
+ + + + 2023 + 3 + 14 + 13 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917510 + 10.1021/acsami.2c18330 + + +
+ + + 36917509 + + 2023 + 03 + 14 + +
+ + 1536-0237 + + + 2023 + Feb + 20 + + + Journal of thoracic imaging + J Thorac Imaging + + The Role and Advantages of Cardiac Magnetic Resonance in the Diagnosis of Myocardial Ischemia. + 10.1097/RTI.0000000000000701 + + Ischemic heart disease continues to be the leading cause of death and disability worldwide. For the diagnosis of ischemic heart disease, some form of cardiac stress test involving exercise or pharmacological stimulation continues to play an important role, despite advances within modalities like computer tomography for the noninvasive detection and characterization of epicardial coronary lesions. Among noninvasive stress imaging tests, cardiac magnetic resonance (CMR) combines several capabilities that are highly relevant for the diagnosis of ischemic heart disease: assessment of wall motion abnormalities, myocardial perfusion imaging, and depiction of replacement and interstitial fibrosis markers by late gadolinium enhancement techniques and T1 mapping. On top of these qualities, CMR is also well tolerated and safe in most clinical scenarios, including in the presence of cardiovascular implantable devices, while in the presence of renal disease, gadolinium-based contrast should only be used according to guidelines. CMR also offers outstanding viability assessment and prognostication of cardiovascular events. The last 2019 European Society of Cardiology guidelines for chronic coronary syndromes has positioned stress CMR as a class I noninvasive imaging technique for the diagnosis of coronary artery disease in symptomatic patients. In the present review, we present the current state-of-the-art assessment of myocardial ischemia by stress perfusion CMR, highlighting its advantages and current shortcomings. We discuss the safety, clinical, and cost-effectiveness aspects of gadolinium-based CMR-perfusion imaging for ischemic heart disease assessment. + Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved. + + + + Silva + Thiago Quinaglia A C + TQAC + + Discipline of Cardiology, Faculty of Medical Science-State University of Campinas-UNICAMP, Campinas, São Paulo, Brazil. + + + Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD. + + + + Pezel + Théo + T + + Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD. + + + Department of Cardiology, University of Paris, CHU Lariboisière, Inserm, UMRS 942, Paris, France. + + + + Jerosch-Herold + Michael + M + + Noninvasive Cardiovascular Imaging Program and Department of Radiology, Brigham and Women's Hospital, Boston, MA. + + + + Coelho-Filho + Otávio R + OR + 0000-0003-4428-5186 + + Discipline of Cardiology, Faculty of Medical Science-State University of Campinas-UNICAMP, Campinas, São Paulo, Brazil. + + + + eng + + Journal Article + + + 2023 + 02 + 20 + +
+ + United States + J Thorac Imaging + 8606160 + 0883-5993 + + IM + The authors declare no conflicts of interest. +
+ + + + 2023 + 3 + 14 + 13 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917509 + 10.1097/RTI.0000000000000701 + 00005382-990000000-00054 + + + + Coelho-Filho OR, Rickers C, Kwong RY, et al. MR myocardial perfusion imaging. Radiology. 2013;266:701–715. + + + Schwitter J, Wacker CM, van Rossum AC, et al. MR-IMPACT: comparison of perfusion-cardiac magnetic resonance with single-photon emission computed tomography for the detection of coronary artery disease in a multicentre, multivendor, randomized trial. Eur Heart J. 2008;29:480–489. + + + Greenwood JP, Maredia N, Younger JF, et al. Cardiovascular magnetic resonance and single-photon emission computed tomography for diagnosis of coronary heart disease (CE-MARC): a prospective trial. Lancet. 2012;379:453–460. + + + Nagel E, Greenwood JP, McCann GP, et al. M-I Investigators. Magnetic resonance perfusion or fractional flow reserve in coronary disease. N Engl J Med. 2019;380:2418–2428. + + + Knuuti J, Wijns W, Saraste A, et al. and ESCSD Group.. 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes. Eur Heart J. 2020;41:407–477. + + + Fihn SD, Gardin JM, Abrams J, et al. American College of Cardiology Foundation, American Heart Association Task Force on Practice Guidlines, American College of Physicians, American Association for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Society for Cardiovascular Agiography, Interventions and Society of Thoracic Surgeons.. 2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS Guideline for the diagnosis and management of patients with stable ischemic heart disease: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, and the American College of Physicians, American Association for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. J Am Coll Cardiol. 2012;60:e44–e164. + + + Wolff SD, Schwitter J, Coulden R, et al. Myocardial first-pass perfusion magnetic resonance imaging: a multicenter dose-ranging study. Circulation. 2004;110:732–737. + + + Giang TH, Nanz D, Coulden R, et al. Detection of coronary artery disease by magnetic resonance myocardial perfusion imaging with various contrast medium doses: first European multi-centre experience. Eur Heart J. 2004;25:1657–1665. + + + Schwitter J, Wacker CM, Wilke N, et al. M-I Investigators. MR-IMPACT II: Magnetic Resonance Imaging for Myocardial Perfusion Assessment in Coronary artery disease Trial: perfusion-cardiac magnetic resonance vs. single-photon emission computed tomography for the detection of coronary artery disease: a comparative multicentre, multivendor trial. Eur Heart J. 2013;34:775–781. + + + Hamon M, Fau G, Nee G, et al. Meta-analysis of the diagnostic performance of stress perfusion cardiovascular magnetic resonance for detection of coronary artery disease. J Cardiovasc Magn Reson. 2010;12:29. + + + Maron DJ, Hochman JS, Reynolds HR, et al. IR Group. Initial invasive or conservative strategy for stable coronary disease. 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+ + + 36917514 + + 2023 + 03 + 14 + +
+ + 1536-0237 + + + 2023 + Feb + 27 + + + Journal of thoracic imaging + J Thorac Imaging + + Are Interstitial Lung Abnormalities a Prognostic Factor of Worse Outcome in COVID-19 Pneumonia? + 10.1097/RTI.0000000000000704 + + To assess the association between interstitial lung abnormalities (ILAs) and worse outcome in patients affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19)-related pneumonia. + The study included patients older than 18 years, who were admitted at the emergency department between February 29 and April 30, 2020 with findings of COVID-19 pneumonia at chest computed tomography (CT), with positive reverse-transcription polymerase chain reaction nasal-pharyngeal swab for SARS-CoV-2, and with the availability of prepandemic chest CT. Prepandemic CTs were reviewed for the presence of ILAs, categorized as fibrotic in cases with associated architectural distortion, bronchiectasis, or honeycombing. Worse outcome was defined as intensive care unit (ICU) admission or death. Cox proportional hazards regression analysis was used to test the association between ICU admission/death and preexisting ILAs. + The study included 147 patients (median age 73 y old; 95% CIs: 71-76-y old; 29% females). On prepandemic CTs, ILA were identified in 33/147 (22%) of the patients, 63% of which were fibrotic ILAs. Fibrotic ILAs were associated with higher risk of ICU admission or death in patients with COVID-19 pneumonia (hazard ratios: 2.73, 95% CIs: 1.50-4.97, P=0.001). + In patients affected by COVID-19 pneumonia, preexisting fibrotic ILAs were an independent predictor of worse prognosis, with a 2.7 times increased risk of ICU admission or death. Chest CT scans obtained before the diagnosis of COVID-19 pneumonia should be carefully reviewed for the presence and characterization of ILAs. + Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved. + + + + Colombi + Davide + D + + Department of Radiological Functions, Azienda USL Piacenza, Piacenza. + + + + Petrini + Marcello + M + + Department of Radiological Functions, Azienda USL Piacenza, Piacenza. + + + + Morelli + Nicola + N + + Department of Radiological Functions, Azienda USL Piacenza, Piacenza. + + + + Silva + Mario + M + + Department of Medicine and Surgery (DiMeC), University of Parma, Parma, Italy. + + + + Milanese + Gianluca + G + + Department of Medicine and Surgery (DiMeC), University of Parma, Parma, Italy. + + + + Sverzellati + Nicola + N + + Department of Medicine and Surgery (DiMeC), University of Parma, Parma, Italy. + + + + Michieletti + Emanuele + E + + Department of Radiological Functions, Azienda USL Piacenza, Piacenza. + + + + eng + + Journal Article + + + 2023 + 02 + 27 + +
+ + United States + J Thorac Imaging + 8606160 + 0883-5993 + + IM + The authors declare no conflicts of interest. +
+ + + + 2023 + 3 + 14 + 13 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917514 + 10.1097/RTI.0000000000000704 + 00005382-990000000-00055 + + + + Hatabu H, Hunninghake GM, Richeldi L, et al. Interstitial lung abnormalities detected incidentally on CT: a Position Paper from the Fleischner Society. Lancet Respir Med. 2020;8:726–737. + + + Washko GR, Hunninghake GM, Fernandez IE, et al. Lung volumes and emphysema in smokers with interstitial lung abnormalities. N Engl J Med. 2011;364:897–906. + + + Hunninghake GM, Hatabu H, Okajima Y, et al. MUC5B promoter polymorphism and interstitial lung abnormalities. N Engl J Med. 2013;368:2192–2200. + + + Hurst JR, Vestbo J, Anzueto A, et al. Susceptibility to exacerbation in chronic obstructive pulmonary disease. N Engl J Med. 2010;363:1128–1138. + + + Harris TB, Launer LJ, Eiriksdottir G, et al. Age, gene/environment susceptibility-Reykjavik study: multidisciplinary applied phenomics. 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Interstitial lung abnormalities and interstitial lung diseases associated with cigarette smoking in a rural cohort undergoing surgical resection. BMC Pulm Med. 2022;22:1–13. + + + Wright JL, Tazelaar HD, Churg A. Fibrosis with emphysema. Histopathology. 2011;58:517–524. + + + Cottin V, Nunes H, Brillet PY, et al. Combined pulmonary fibrosis and emphysema: a distinct underrecognised entity. Eur Respir J. 2005;26:586–593. + + + +
+ + + 36917500 + + 2023 + 03 + 14 + +
+ + 2162-5220 + + 34 + 1 + + 2023 Jan-Feb + + + Dermatitis : contact, atopic, occupational, drug + Dermatitis + + Vitiligo-Like Depigmentation Induced by Anti-Programmed Death 1 Antibody. + + 66-67 + + 10.1089/DERM.0000000000000932 + + + Zhang + Li-Wen + LW + + Department of Dermatovenereology, Chengdu Second People's Hospital, China, 13980427003@163.com. + + + + Fu + Li-Xin + LX + + Department of Dermatovenereology, Chengdu Second People's Hospital, China, 13980427003@163.com. + + + + Wang + Wen-Ju + WJ + + Department of Dermatovenereology, Chengdu Second People's Hospital, China, 13980427003@163.com. + + + + Lu + Yong-Hong + YH + + Department of Dermatovenereology, Chengdu Second People's Hospital, China, 13980427003@163.com. + + + + Chen + Tao + T + + Department of Dermatovenereology, Chengdu Second People's Hospital, China, 13980427003@163.com. + + + + eng + + Letter + +
+ + United States + Dermatitis + 101207335 + 1710-3568 + + IM +
+ + + + 2023 + 3 + 14 + 13 + 2 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + ppublish + + 36917500 + 10.1089/DERM.0000000000000932 + + +
+ + + 36917501 + + 2023 + 03 + 14 + +
+ + 2162-5220 + + 34 + 1 + + 2023 Jan-Feb + + + Dermatitis : contact, atopic, occupational, drug + Dermatitis + + Self-Assessment. + + 1-3 + + 10.1089/derm.2022.28999.sas + + + Feigenbaum + Lawrence S + LS + + Alliance Health & Dermatology, 304 S. Mt. Auburn Road, Cape Girardeau, Missouri 63703. + + + + Montañez-Wiscovich + Marjorie E + ME + + University of Florida, College of Medicine, Department of Dermatology, 4037 NW 86th Terrace, Gainesville, Florida 32606. + + + + eng + + Journal Article + +
+ + United States + Dermatitis + 101207335 + 1710-3568 + + IM +
+ + + + 2023 + 3 + 14 + 13 + 2 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + ppublish + + 36917501 + 10.1089/derm.2022.28999.sas + + +
+ + + 36917502 + + 2023 + 03 + 14 + +
+ + 2162-5220 + + 34 + 1 + + 2023 Jan-Feb + + + Dermatitis : contact, atopic, occupational, drug + Dermatitis + + Lanolin. + + 4-12 + + 10.1089/derm.2022.0002 + + Lanolin is a complex mixture of high molecular weight esters, aliphatic alcohols, sterols, fatty acids, and hydrocarbons that has been widely used for centuries for its emollient properties. The purification of crude lanolin into lanolin wax and the processing of this wax into various derivatives began in 1882 and continue to this day with newer highly purified anhydrous lanolins. Controversy as to lanolin's allergenicity began in the 1920s and remains an issue. The most appropriate patch test preparation(s) for detecting allergy remain disputed. Detection of lanolin-induced contact dermatitis in diseased skin by patch testing on normal skin may lead to false negative results. Patients with a positive patch test to lanolin may tolerate use of lanolin on normal skin. Although lanolin is a weak sensitizer and the frequency of contact allergy to it in the European population reportedly is 0.4%, there are high-risk concomitant conditions: stasis dermatitis, leg ulcers, perianal/genital dermatitis, and atopic dermatitis (AD). Children and the elderly are also at greater risk of developing contact allergy to lanolin, partly because of comorbidities (AD and stasis dermatitis/leg ulcers, respectively). Finally, in the United States, non-Hispanic white patients are more likely than their non-Hispanic black counterparts to be lanolin allergic. + + + + Jenkins + Blair A + BA + + From the Department of Dermatology, Columbia University Irving Medical Center, New York, New York, USA. + + + + Belsito + Donald V + DV + 0000-0003-1229-6673 + + From the Department of Dermatology, Columbia University Irving Medical Center, New York, New York, USA. + + + D.V.B. is a member of the expert panel for cosmetic ingredient safety, Washington, DC, and the expert panel for fragrance safety, Woodcliff Lake, NJ. + + + + eng + + Journal Article + +
+ + United States + Dermatitis + 101207335 + 1710-3568 + + IM +
+ + + + 2023 + 3 + 14 + 13 + 2 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + ppublish + + 36917502 + 10.1089/derm.2022.0002 + + +
+ + + 36917525 + + 2023 + 03 + 14 + +
+ + 2162-5220 + + + 2023 + Jan + 19 + + + Dermatitis : contact, atopic, occupational, drug + Dermatitis + + Photoallergic Contact Dermatitis to Menthyl Anthranilate (Meradimate). + 10.1089/derm.2022.0048 + + + Battis + Nicholas + N + 0000-0001-9301-9138 + + From the Contact Dermatitis Clinic, Park Nicollet Health System, Minneapolis, Minnesota, USA. + + + + Ekstein + Samuel F + SF + 0000-0003-2418-3537 + + From the Contact Dermatitis Clinic, Park Nicollet Health System, Minneapolis, Minnesota, USA. + + + + Neeley + Anne B + AB + + Department of Dermatology, Park Nicollet Health Services, Minneapolis, Minnesota, USA. + + + + eng + + Journal Article + + + 2023 + 01 + 19 + +
+ + United States + Dermatitis + 101207335 + 1710-3568 + + IM +
+ + + + 2023 + 3 + 14 + 13 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917525 + 10.1089/derm.2022.0048 + + +
+ + + 36917516 + + 2023 + 03 + 14 + +
+ + 1520-5851 + + + 2023 + Mar + 14 + + + Environmental science & technology + Environ Sci Technol + + Core Species Derived from Multispecies Interactions Facilitate the Immobilization of Cadmium. + 10.1021/acs.est.3c00486 + + Microbial consortia have opened new avenues for heavy-metal remediation. However, the limited understanding of the overall effect of interspecific interactions on remediation efficacy hinders its application. Here, the effects of multispecies growth and biofilm formation on Cd immobilization were explored from direct and multiple interactions through random combinations of two or three rhizosphere bacteria. In monocultures, Cd stress resulted in an average decrease in planktonic biomass of 26%, but through cooperation, the decrease was attenuated in dual (21%) and triple cultures (13%), possibly involving an increase in surface polysaccharides. More than 65% of the co-cultures exhibited induction of biofilm formation under Cd stress, which further enhanced the role of biofilms in Cd immobilization. Notably, excellent biofilm-forming ability or extensive social induction makes Pseudomonas putida and Brevundimonas diminuta stand out in multispecies biofilm formation and Cd immobilization. These two core species significantly increase the colonization of soil microorganisms on rice roots compared to the control, resulting in a 40% decrease in Cd uptake by rice. Our study enhances the understanding of bacterial interactions under Cd stress and provides a novel strategy for adjusting beneficial soil consortia for heavy-metal remediation. + + + + Xing + Yonghui + Y + + State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, P. R. China. + + + + Liu + Song + S + + State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, P. R. China. + + + + Tan + Shuxin + S + + State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, P. R. China. + + + + Jiang + Yi + Y + + State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, P. R. China. + + + + Luo + Xuesong + X + + State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, P. R. China. + + + Hubei Key Laboratory of Soil Environment and Pollution Remediation, Huazhong Agricultural University, Wuhan 430070, P. R. China. + + + + Hao + Xiuli + X + 0000-0002-7963-6356 + + State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, P. R. China. + + + Hubei Key Laboratory of Soil Environment and Pollution Remediation, Huazhong Agricultural University, Wuhan 430070, P. R. China. + + + + Huang + Qiaoyun + Q + 0000-0002-2733-8066 + + State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, P. R. China. + + + Hubei Key Laboratory of Soil Environment and Pollution Remediation, Huazhong Agricultural University, Wuhan 430070, P. R. China. + + + + Chen + Wenli + W + 0000-0003-1717-1263 + + State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, P. R. China. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Environ Sci Technol + 0213155 + 0013-936X + + IM + + biofilm consortia + bioremediation + cadmium + core species + interactions + +
+ + + + 2023 + 3 + 14 + 13 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917516 + 10.1021/acs.est.3c00486 + + +
+ + + 36917518 + + 2023 + 03 + 14 + +
+ + 2162-5220 + + + 2023 + Jan + 18 + + + Dermatitis : contact, atopic, occupational, drug + Dermatitis + + Burden of Disease and Unmet Needs in Atopic Dermatitis: Results From a Patient Survey. + 10.1089/derm.2022.29015.jsi + + Background: Atopic dermatitis (AD) affects 2%-10% of adults worldwide. Occurrence and severity of symptoms and treatment success vary among patients. Objective: To determine disease severity, burden, and treatment use and satisfaction in adults with AD. Methods: An international internet-based survey was conducted (October 5-November 1, 2021) in participants with AD from Canada, France, Germany, Italy, Japan, Spain, the United Kingdom, and the United States. Results: Of 2005 AD patients surveyed, 92% had body surface area (BSA) involvement <10%. Itch was the most bothersome symptom; 48.5% of participants reported severe itch in the past week (Itch Numerical Rating Scale [NRS] 7-10; 45.9% for BSA <10%, 75.0% for BSA ≥10%). Most participants reported moderate or severe sleep disturbance in the past week (Sleep NRS 4-10; 67.1% for BSA <10%, 92.3% for BSA ≥10%). Itch was the top reason for participants' most recent health care provider visit; reducing itching was their top treatment goal. Topical therapies, which were most commonly used, resulted in low treatment satisfaction. Conclusions: Itch was the most bothersome AD symptom. Although clinical development has focused on improving skin lesions, improving itch is patients' top treatment goal. This survey highlights the need for systemic antipruritic therapies that could reduce itch in nonlesional and lesional skin. + + + + Silverberg + Jonathan I + JI + + From Department of Dermatology, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA. + + + + Mohawk + Jennifer A + JA + + Cara Therapeutics, Stamford, Connecticut, USA. + + + + Cirulli + Joshua + J + + Cara Therapeutics, Stamford, Connecticut, USA. + + + + Nograles + Kristine + K + + Cara Therapeutics, Stamford, Connecticut, USA. + + + + Punzalan + Joseph C + JC + + AplusA Bell Falla, LLC, Newark, New Jersey, USA. + + + + Kelly + Kevin M + KM + + AplusA Bell Falla, LLC, Newark, New Jersey, USA. + + + + Kim + Brian S + BS + + The Kimberly and Eric J. Waldman Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA. + + + + Guttman-Yassky + Emma + E + + The Kimberly and Eric J. Waldman Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA. + + + + Lebwohl + Mark + M + + The Kimberly and Eric J. Waldman Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA. + + + + eng + + Journal Article + + + 2023 + 01 + 18 + +
+ + United States + Dermatitis + 101207335 + 1710-3568 + + IM +
+ + + + 2023 + 3 + 14 + 13 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917518 + 10.1089/derm.2022.29015.jsi + + +
+ + + 36917517 + + 2023 + 03 + 14 + +
+ + 1467-9566 + + + 2023 + Mar + 14 + + + Sociology of health & illness + Sociol Health Illn + + Can a disability studies-medical sociology rapprochement help re-value the work disabled people do within their rehabilitation? + 10.1111/1467-9566.13627 + + This paper draws attention to the health-related work that disabled people do when engaging with rehabilitation services. Medical sociology has a rich history of looking at the 'illness work' that patients do, while disability studies scholars have explored the cultural value placed upon paid work and the effects on social status of being unable to work. Yet, a longstanding froideur between these two disciplines, which have fundamentally opposed ontologies of illness and disability, means that neither discipline has attended closely to the rehabilitation-related work that disabled people do. The concept of 'adjusting' to illness highlights seemingly irreconcilable disciplinary differences. Yet this article argues that the notion of 'adjustment work' can elucidate the socio-political character of the work disabled people do in their rehabilitation, which could create a more substantial and sustainable dialogue on this subject between disability studies and medical sociology. To make this case, we discuss interview data from the Rights-based Rehabilitation project, which sought to explore disabled people's lived experiences of rehabilitation. + © 2023 The Authors. Sociology of Health & Illness published by John Wiley & Sons Ltd on behalf of Foundation for the Sociology of Health & Illness. + + + + Cooper + Harriet + H + https://orcid.org/0000-0002-0510-2669 + + Norwich Medical School, University of East Anglia, Norwich, UK. + + + + Poland + Fiona + F + + School of Health Sciences, University of East Anglia, Norwich, UK. + + + + Kale + Swati + S + + School of Health Sciences, University of East Anglia, Norwich, UK. + + + + Shakespeare + Tom + T + + International Centre for Evidence in Disability, London School of Hygiene and Tropical Medicine, London, UK. + + + + eng + + + National Institute for Health and Care Research Applied Research Collaboration East of England at Cambridge and Peterborough NHS Foundation Trust + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + England + Sociol Health Illn + 8205036 + 0141-9889 + + IM + + disability studies + disabled people + medical sociology + patient and public involvement + rehabilitation + value + work + +
+ + + + 2022 + 02 + 09 + + + 2023 + 01 + 30 + + + 2023 + 3 + 14 + 13 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917517 + 10.1111/1467-9566.13627 + + + REFERENCES + + Abberley, P. (1993). Disabled people and normality. In J. Swain, S. French, C. Barnes, & C. Thomas (Eds.), Disabling barriers - Enabling environments (2nd ed., pp. 13-20). Sage. https://doi.org/10.1017/S0047279406379779 + + + Abberley, P. (1995). Disabling ideology in health and welfare-the case of occupational therapy. Disability & Society, 10(2), 221-232. https://doi.org/10.1080/09687599550023660 + + + Alford, V. M., Ewen, S., Webb, G. R., Alison, J. M., Brookes, A., & Remedios, L. J. (2015). The use of the international classification of functioning, disability and health to understand the health and functioning experiences of people with chronic conditions from the person perspective: A systematic review. Disability and Rehabilitation, 37(8), 655-666. https://doi.org/10.3109/09638288.2014.935875 + + + Armstrong, D. (2014). Actors, patients and agency: A recent history. Sociology of Health & Illness, 36(2), 163-174. https://doi.org/10.1111/1467-9566.12100 + + + Barnes, C. (2012). Re-thinking disability, work and welfare. Sociology Compass, 6(6), 472-484. https://doi.org/10.1111/j.1751-9020.2012.00464.x + + + Barnes, C., & Oliver, M. (1993). Disability: A sociological phenomenon ignored by sociologists. Leeds Disability Studies Archive. https://disability-studies.leeds.ac.uk/wp-content/uploads/sites/40/library/Barnes-soc-phenomenon.pdf + + + Beresford, P., & Branfield, F. (2012). Building solidarity, ensuring diversity: Lessons from service users and disabled people’s movements. In M. Barnes & P. Cotterell (Eds.), Critical perspectives on user involvement (pp. 33-45). The Policy Press. + + + Bezmez, D. (2016). Looking for a ‘cure’: Negotiating ‘walking’ in a Turkish rehabilitation hospital. Disability & Society, 31(3), 389-405. https://doi.org/10.1080/09687599.2016.1167670 + + + Blaikie, N. (2007). Approaches to social enquiry: Advancing knowledge. Polity. + + + Bourke, J. A., Hay-Smith, E. J. C., Snell, D. L., & DeJong, G. (2015). Attending to biographical disruption: The experience of rehabilitation following tetraplegia due to spinal cord injury. Disability & Rehabilitation, 37(4), 296-303. https://doi.org/10.3109/09638288.2014.918188 + + + Bury, M. (2010). Chronic illness, self-management and the rhetoric of empowerment. In G. Scambler & S. Scambler (Eds.), New directions in the sociology of chronic and disabling conditions (pp. 161-179). Palgrave Macmillan. + + + Bury, M. (1982). Chronic illness as biographical disruption. Sociology of Health & Illness, 4(2), 167-182. https://doi.org/10.1111/1467-9566.ep11339939 + + + Bury, M. (1987). Review of Gritzer, G. & Arluke, A. The making of rehabilitation. Sociology of Health & Illness, 9(2), 213-214. https://doi.org/10.1111/1467-9566.ep11346982 + + + Charmaz, K. (1983). Loss of self: A fundamental form of suffering in the chronically ill. Sociology of Health & Illness, 5(2), 168-195. https://doi.org/10.1111/1467-9566.ep10491512 + + + Clare, E. (2015). Exile and pride: Disability, queerness and liberation. Duke University Press. + + + Cooper, H. (2020). Critical disability studies and the disabled child: Unsettling distinctions. Routledge. + + + Cooper, H. (2021). Rights-based rehabilitation: How can disabled people be involved in shaping services? Unpublished doctoral thesis. University of East Anglia. + + + Corbin, J., & Strauss, A. (1985). Managing chronic illness at home: Three lines of work. Qualitative Sociology, 8(3), 224-247. https://doi.org/10.1007/bf00989485 + + + Creswell, J. W., & Poth, C. N. (2016). Qualitative inquiry and research design: Choosing among five approaches (3rd ed.). Sage. + + + Crow, L. (2014). Scroungers and superhumans: Images of disability from the summer of 2012: A visual inquiry. Journal of Visual Culture, 13(2), 168-181. https://doi.org/10.1177/1470412914529109 + + + Duffy, S. (2013). A fair society? How the cuts target disabled people. Centre for Welfare Reform. + + + Fadyl, J., Teachman, G., & Hamdani, Y. (2020). Problematizing ‘productive citizenship’ within rehabilitation services: Insights from three studies. Disability and Rehabilitation, 42(20), 2959-2966. https://doi.org/10.1080/09638288.2019.1573935 + + + Gibson, B. (2016). Rehabilitation: A post-critical approach. CRC Press. + + + Gleeson, B. (1999). Geographies of disability. Routledge. + + + Goodley, D. (2011). Disability studies: An interdisciplinary introduction. Sage. + + + Grue, J. (2016). Illness is work: Revisiting the concept of illness careers and recognizing the identity work of patients with ME/CFS. Health, 20(4), 401-412. https://doi.org/10.1177/1363459315628044 + + + Haldar, M., Engebretsen, E., & Album, D. (2016). Legitimating the illegitimate: How doctors manage their knowledge of the prestige of diseases. Health, 20(6), 559-577. https://doi.org/10.1177/1363459315596798 + + + Harris, R., Wathen, N., & Wyatt, S. (2010). Working to be healthy? Empowering citizens or consumers? In R. Harris, N. Wathen, & S. Wyatt (Eds.), Configuring health consumers: Health work and the imperative of personal responsibility (pp. 211-224). Palgrave Macmillan. + + + Mason, J. (2018). Qualitative researching. Sage. + + + Mei, C., Reilly, S., Reddihough, D., Mensah, F., Green, J., Pennington, L., & Morgan, A. T. (2015). Activities and participation of children with cerebral palsy: Parent perspectives. Disability & Rehabilitation, 37(23), 2164-2173. https://doi.org/10.3109/09638288.2014.999164 + + + Morgan, D. L. (2014). Pragmatism as a paradigm for social research. Qualitative Inquiry, 20(8), 1045-1053. https://doi.org/10.1177/1077800413513733 + + + Oliver, M. (1992). Changing the social relations of research production? Disability, Handicap & Society, 7(2), 101-114. https://doi.org/10.1080/02674649266780141 + + + Oliver, M. (1993). What’s so wonderful about walking? Inaugural professorial lecture. University of Greenwich. Retrieved from http://disability-studies.leeds.ac.uk/files/library/Oliver-PROFLEC.pdf + + + Papadimitriou, C., & Stone, D. A. (2011). Addressing existential disruption in traumatic spinal cord injury: A new approach to human temporality in inpatient rehabilitation. Disability & Rehabilitation, 33(21-22), 2121-2133. https://doi.org/10.3109/09638288.2011.555597 + + + Parsons, T. (1951). The social system. Free Press. + + + Rose, N. (1999). Governing the soul: The shaping of the private self (2nd ed.). Routledge. + + + Scambler, G. (2009). Health-related stigma. Sociology of Health & Illness, 31(3), 441-455. https://doi.org/10.1111/j.1467-9566.2009.01161.x + + + Scambler, G., & Scambler, S. (2010). Introduction: The sociology of chronic and disabling conditions; Assaults on the lifeworld. In G. Scambler & S. Scambler (Eds.), New directions in the sociology of chronic and disabling conditions (pp. 1-7). Palgrave Macmillan. + + + Shakespeare, T. (2014). Disability rights and wrongs revisited (2nd ed.). Routledge. + + + Shakespeare, T., Cooper, H., Bezmez, D., & Poland, F. (2018). Rehabilitation as a disability equality issue: A conceptual shift for disability studies? Social Inclusion, 6(1), 61-72. https://doi.org/10.17645/si.v6i1.1175 + + + Shakespeare, T., & Watson, N. (2010). Beyond models: Understanding the complexity of disabled people’s lives. In G. Scambler & S. Scambler (Eds.), New directions in the sociology of chronic and disabling conditions (pp. 57-77). Palgrave Macmillan. + + + Sheppard, E. (2020). Performing normal but becoming crip: Living with chronic pain. Scandinavian Journal of Disability Research, 22(1), 39-47. https://doi.org/10.16993/sjdr.619 + + + Spartacus Network. (2015). Spartacus response to cuts in ESA. http://www.centreforwelfarereform.org/library/categories/disability/spartacus-response-to-cuts-in-esa.html + + + Strathclyde Centre for Disability Research and Glasgow Media Unit. (2011). Bad news for disabled people: How the newspapers are reporting disability. https://www.gla.ac.uk/media/Media_214917_smxx.pdf + + + Taylor, S. (2004, 1 March). Right not to work: Power and disability. Monthly Review. https://monthlyreview.org/2004/03/01/the-right-not-to-work-power-and-disability/ + + + Thomas, C. (2010). Medical sociology and disability theory. In G. Scambler & S. Scambler (Eds.), New directions in the sociology of chronic and disabling conditions (pp. 37-56). Palgrave Macmillan. + + + Tizard Centre. (2020). Becoming less eligible: Intellectual disability services in the age of austerity. NIHR School for Social Care Research. https://www.sscr.nihr.ac.uk/wp-content/uploads/SSCR-research-findings_RF100.pdf + + + Van de Velde, D., Bracke, P., Van Hove, G., Josephsson, S., Devisch, I., & Vanderstraeten, G. (2012). The illusion and the paradox of being autonomous, experiences from persons with spinal cord injury in their transition period from hospital to home. Disability & Rehabilitation, 34(6), 491-502. https://doi.org/10.3109/09638288.2011.608149 + + + Watson, N. (2002). Well, I know this is going to sound very strange to you, but I don't see myself as a disabled person: Identity and disability. Disability & Society, 17(5), 509-527. https://doi.org/10.1080/09687590220148496 + + + We are Spartacus. (2013). People’s review of the work capability assessment. http://www.centreforwelfarereform.org/library/by-date/peoples-review-of-wca-further-evidence.html + + + Whalley Hammell, K. (2004). Deviating from the norm: A sceptical interrogation of the classificatory practices of the ICF. British Journal of Occupational Therapy, 67(9), 408-411. https://doi.org/10.1177/030802260406700906 + + + Whalley Hammell, K. (2006). Perspectives on disability and rehabilitation. Churchill Livingstone. + + + WHO - World Health Organization. (2011). World report on disability. World Health Organization. + + + WHO - World Health Organisation. (2001). International classification of functioning, disability and health (ICF). Retrieved from https://www.who.int/classifications/international-classification-of-functioning-disability-and-health + + + Williams, G. (1984). The genesis of chronic illness: Narrative re-construction. Sociology of Health & Illness, 6(2), 175-200. https://doi.org/10.1111/1467-9566.ep10778250 + + + Winance, M. (2006). Trying out the wheelchair: The mutual shaping of people and devices through adjustment. Science, Technology & Human Values, 31(1), 52-72. https://doi.org/10.1177/0162243905280023 + + + Zarb, G. (1992). On the road to Damascus: First steps towards changing the relations of disability research production. Disability, Handicap & Society, 7(2), 125-138. https://doi.org/10.1080/02674649266780161 + + + +
+ + + 36917519 + + 2023 + 03 + 14 + +
+ + 2162-5220 + + + 2023 + Jan + 24 + + + Dermatitis : contact, atopic, occupational, drug + Dermatitis + + Localized Nummular Dermatitis of the Bilateral Breasts Developing 4 Months After Breast Reduction Surgery. + 10.1089/derm.2022.0008 + + + Miller + John + J + 0000-0001-9132-5254 + + + James + William + W + + Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. + + + + eng + + Journal Article + + + 2023 + 01 + 24 + +
+ + United States + Dermatitis + 101207335 + 1710-3568 + + IM +
+ + + + 2023 + 3 + 14 + 13 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917519 + 10.1089/derm.2022.0008 + + +
+ + + 36917523 + + 2023 + 03 + 14 + +
+ + 2162-5220 + + + 2023 + Jan + 25 + + + Dermatitis : contact, atopic, occupational, drug + Dermatitis + + Teaching Patients to Teach Themselves (Not by Rote but) via Repeated Open Application Test. + 10.1089/derm.2022.0001 + + + Nowakowska + Malgorzata K + MK + 0000-0001-5756-1878 + + From the School of Medicine, Baylor College of Medicine, Houston, Texas, USA. + + + + Sierro + Tiffany + T + + Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas, USA. + + + + Cruz + Ponciano D + PD + + Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas, USA. + + + + eng + + Journal Article + + + 2023 + 01 + 25 + +
+ + United States + Dermatitis + 101207335 + 1710-3568 + + IM +
+ + + + 2023 + 3 + 14 + 13 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917523 + 10.1089/derm.2022.0001 + + +
+ + + 36917522 + + 2023 + 03 + 14 + +
+ + 2162-5220 + + + 2023 + Jan + 23 + + + Dermatitis : contact, atopic, occupational, drug + Dermatitis + + Ocular Adverse Events in Patients With Atopic Dermatitis Treated With Upadacitinib: A Real-Life Experience. + 10.1089/derm.2022.0063 + + Background: Dupilumab, an interleukin (IL)-4 receptor-α inhibitor that blocks IL-4 and IL-13 signaling pathways, is an effective and well-tolerated therapy for moderate-to-severe atopic dermatitis (AD). However, an increased incidence of dupilumab-associated conjunctivitis has been reported in patients treated with dupilumab. In contrast, upadacitinib, a selective Janus kinase 1 inhibitor, is reported to have lower incidence of conjunctivitis than dupilumab. Objective: The aim of this retrospective study was to investigate ocular adverse events in adult patients with moderate-to-severe AD treated with upadacitinib after discontinuing treatment with dupilumab. Methods: In total, 33 patients were examined at the start of treatment with upadacitinib after discontinuation of dupilumab, then again after 4 weeks and every 12 weeks up to a maximum of 72 weeks. Results: Among the patients in the study, 14 had developed dupilumab-associated conjunctivitis during dupilumab treatment and had complete resolution of ocular symptoms after the switch to upadacitinib within the 1-month follow-up visit. In addition, only 1 patient treated with upadacitinib developed an episode of conjunctivitis. This condition was of mild severity and it spontaneously resolved quickly. Interestingly, this patient had no history of dupilumab-associated conjunctivitis. Conclusions: All patients who developed dupilumab-associated conjunctivitis experienced complete remission on upadacitinib and only 3% of the patients in our sample developed conjunctivitis after the start of treatment with upadacitinib. In light of this, upadacitinib appears to be a prudent and safe treatment option for AD patients with uncontrolled ocular symptoms associated with dupilumab therapy. + + + + Gelato + Federica + F + 0000-0002-7028-0322 + + From the *Dermatology Clinic, Department of Medical Sciences, University of Turin, Turin, Italy. + + + + Mastorino + Luca + L + + From the *Dermatology Clinic, Department of Medical Sciences, University of Turin, Turin, Italy. + + + + Quaglino + Pietro + P + + From the *Dermatology Clinic, Department of Medical Sciences, University of Turin, Turin, Italy. + + + + Cavaliere + Giovanni + G + + From the *Dermatology Clinic, Department of Medical Sciences, University of Turin, Turin, Italy. + + + + Ortoncelli + Michela + M + + From the *Dermatology Clinic, Department of Medical Sciences, University of Turin, Turin, Italy. + + + + Ribero + Simone + S + + From the *Dermatology Clinic, Department of Medical Sciences, University of Turin, Turin, Italy. + + + + eng + + Journal Article + + + 2023 + 01 + 23 + +
+ + United States + Dermatitis + 101207335 + 1710-3568 + + IM +
+ + + + 2023 + 3 + 14 + 13 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917522 + 10.1089/derm.2022.0063 + + +
+ + + 36917515 + + 2023 + 03 + 14 + +
+ + 1465-3362 + + + 2023 + Mar + 14 + + + Drug and alcohol review + Drug Alcohol Rev + + The health needs of people leaving prison with a history of methamphetamine and/or opioid use. + 10.1111/dar.13636 + + Methamphetamine use is more common than opioid use among prison entrants in some countries, including Australia, yet most research and policy focuses on opioid use. This suggests that traditional opioid-focused interventions are no longer appropriate for the majority of this group in countries such as Australia. To inform policy and practice, we compared socio-demographic characteristics and health needs of people leaving prison with a history of methamphetamine use and/or opioid use. + A cross-sectional survey of incarcerated adults administered the World Health Organization Alcohol, Smoking and Substance Involvement Screening Test was used to identify moderate-/high-risk methamphetamine use (n = 909), opioid use (n = 115) or combined methamphetamine/opioid use (n = 356) before incarceration. We compared groups using modified log-linked Poisson regression with robust error variance. + Compared to the opioid-only group, the methamphetamine-only group were: significantly more often aged <25 years; significantly more likely to identify as Indigenous; significantly less likely to have a history of prior incarceration, drug injection or overdose. A significantly lower proportion of methamphetamine-only and methamphetamine-and-opioid participants self-reported current hepatitis C infection compared to opioid-only participants. A majority of participants in all groups screened positive for current psychological distress according to the K10. + People leaving prison with a history of methamphetamine use differ from opioid users with respect to demographics, patterns of substance use and related health concerns. Treatment and harm reduction efforts for people who experience incarceration must respond to patterns of drug use in this population, and invest at scale in coordinated, continuous services for co-occurring substance use and mental health problems. + © 2023 The Authors. Drug and Alcohol Review published by John Wiley & Sons Australia, Ltd on behalf of Australasian Professional Society on Alcohol and other Drugs. + + + + Cumming + Craig + C + https://orcid.org/0000-0002-2556-3294 + + Centre for Health Services Research, School of Population and Global Health, University of Western Australia, Perth, Australia. + + + + Kinner + Stuart A + SA + https://orcid.org/0000-0003-3956-5343 + + Centre for Adolescent Health, Murdoch Children's Research Institute, Melbourne, Australia. + + + Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia. + + + Griffith Criminology Institute, Griffith University, Brisbane, Australia. + + + School of Population Health, Curtin University, Perth, Australia. + + + + McKetin + Rebecca + R + https://orcid.org/0000-0003-2833-4830 + + National Drug and Alcohol Research Centre, UNSW Sydney, Sydney, Australia. + + + + Li + Ian + I + + School of Population and Global Health, University of Western Australia, Perth, Australia. + + + + Preen + David B + DB + + Centre for Health Services Research, School of Population and Global Health, University of Western Australia, Perth, Australia. + + + + eng + + + 1002463 + National Health and Medical Research Council + + + + 409966 + National Health and Medical Research Council + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + Australia + Drug Alcohol Rev + 9015440 + 0959-5236 + + IM + + harm reduction + methamphetamine + opioid + prisons + substance-related disorders + +
+ + + + 2023 + 01 + 30 + + + 2022 + 09 + 14 + + + 2023 + 02 + 12 + + + 2023 + 3 + 14 + 13 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917515 + 10.1111/dar.13636 + + + REFERENCES + + McKetin R, Degenhardt L, Shanahan M, Baker AL, Lee NK, Lubman DI. Health service utilisation attributable to methamphetamine use in Australia: patterns, predictors and national impact. Drug Alcohol Rev. 2018;37:196-204. + + + Winkelman TN, Admon LK, Jennings L, Shippee ND, Richardson CR, Bart G. Evaluation of amphetamine-related hospitalizations and associated clinical outcomes and costs in the United States. JAMA Netw Open. 2018;1:e183758. + + + Han B, Cotto J, Etz K, Einstein EB, Compton WM, Volkow ND. Methamphetamine overdose deaths in the US by sex and race and ethnicity. JAMA Psychiat. 2021;78:564-7. + + + Butler A, Nicholls T, Samji H, Fabian S, Lavergne MR. Prevalence of mental health needs, substance use, and co-occurring disorders among people admitted to prison. Psychiatr Serv. 2022;73:737-44. + + + Bukten A, Lund IO, Kinner SA, Rognli EB, Havnes IA, Muller AE, et al. Factors associated with drug use in prison-results from the Norwegian offender mental health and addiction (NorMA) study. Health Justice. 2020;8:10. + + + Australian Institute of Health and Welfare. The health of Australia's prisoners 2018. Canberra: AIHW; 2019 Contract No.: Cat. no. PHE 246. + + + World Health Organization. Preventing overdose deaths in the criminal-justice system. 2014. + + + Kinner SA, Moore E, Spittal MJ, Indig D. Opiate substitution treatment to reduce in-prison drug injection: a natural experiment. Int J Drug Policy. 2013;24:460-3. + + + Rubin R. US prisons missing opportunities to tackle HIV in inmates. Lancet. 2016;388:1041-2. + + + Moore KE, Roberts W, Reid HH, Smith KM, Oberleitner LM, McKee SA. Effectiveness of medication assisted treatment for opioid use in prison and jail settings: a meta-analysis and systematic review. J Subst Abuse Treat. 2019;99:32-43. + + + The University of Melbourne. Health After Release from Prison (HARP) cohort study. Melbourne: The University of Melbourne; n.d. Available from: https://mspgh.unimelb.edu.au/research-groups/centre-for-health-equity/justice-health-unit/health-after-release-from-prison-harp-cohort-study + + + Humeniuk R, Henry-Edwards S, Ali R, Poznyak V, Monteiro M. The Alcohol, Smoking and Substance involvement Screening Test (ASSIST): manual for use in primary care; 2010. Report No.: 9241599383. Geneva: World Health Organization. + + + Australian Bureau of Statistics. National Health Survey: first results. Canberra: Australian Bureau of Statistics; 2018. Available from: https://www.abs.gov.au/statistics/health/health-conditions-and-risks/national-health-survey-first-results/latest-release#data-download + + + Kessler RC, Barker PR, Colpe LJ, Epstein JF, Gfroerer JC, Hiripi E, et al. Screening for serious mental illness in the general population. Arch Gen Psychiatry. 2003;60:184-9. + + + Australian Bureau of Statistics. 4363.0-National Health Survey: users' guide, 2014-15. Canberra: Australian Bureau of Statistics; 2017. Available from: https://www.abs.gov.au/ausstats/abs@.nsf/Lookup/by%20Subject/4363.0~2014-15~Main%20Features~Kessler%20Psychological%20Distress%20Scale-10%20(K10)~35 + + + Zou G. A modified Poisson regression approach to prospective studies with binary data. Am J Epidemiol. 2004;159:702-6. + + + StataCorp. Stata statistical software: release 16. College Station, TX: StataCorp LLC; 2019. + + + Winter RJ, Stoové M, Degenhardt L, Hellard ME, Spelman T, Jenkinson R, et al. Incidence and predictors of non-fatal drug overdose after release from prison among people who inject drugs in Queensland, Australia. Drug Alcohol Depend. 2015;153:43-9. + + + Binswanger IA, Blatchford PJ, Mueller SR, Stern MF. Mortality after prison release: opioid overdose and other causes of death, risk factors, and time trends from 1999 to 2009. Ann Intern Med. 2013;159:592-600. + + + Keen C, Young JT, Borschmann R, Kinner SA. Non-fatal drug overdose after release from prison: a prospective data linkage study. Drug Alcohol Depend. 2020;206:107707. + + + Groenkjaer M, de Crespigny C, Liu D, Moss J, Cairney I, Lee D, et al. “The Chicken or the Egg”: barriers and facilitators to collaborative care for people with comorbidity in a metropolitan region of South Australia. Issues Ment Health Nurs. 2017;38:18-24. + + + Kwon JA, Dore GJ, Hajarizadeh B, Alavi M, Valerio H, Grebely J, et al. Australia could miss the WHO hepatitis C virus elimination targets due to declining treatment uptake and ongoing burden of advanced liver disease complications. PLoS One. 2021;16:e0257369. + + + Department of Health and Aged Care. About sexual health: Australian Government. 2022. Available from: https://www.health.gov.au/topics/sexual-health/about#sexual-health-in-australia + + + Cheng WS, Garfein RS, Semple SJ, Strathdee SA, Zians JK, Patterson TL. Increased drug use and STI risk with injection drug use among HIV-seronegative heterosexual methamphetamine users. J Psychoactive Drugs. 2010;42:11-8. + + + Strickland JC, Stoops WW, Dunn KE, Smith KE, Havens JR. The continued rise of methamphetamine use among people who use heroin in the United States. Drug Alcohol Depend. 2021;225:108750. + + + Hoots B, Vivolo-Kantor A, Seth P. The rise in non-fatal and fatal overdoses involving stimulants with and without opioids in the United States. Addiction. 2020;115:946-58. + + + Chan B, Freeman M, Ayers C, Korthuis PT, Paynter R, Kondo K, et al. A systematic review and meta-analysis of medications for stimulant use disorders in patients with co-occurring opioid use disorders. Drug Alcohol Depend. 2020;216:108193. + + + Tiihonen J, Krupitsky E, Verbitskaya E, Blokhina E, Mamontova O, Föhr J, et al. Naltrexone implant for the treatment of polydrug dependence: a randomized controlled trial. Am J Psychiatry. 2012;169:531-6. + + + Frost MC, Lampert H, Tsui JI, Iles-Shih MD, Williams EC. The impact of methamphetamine/amphetamine use on receipt and outcomes of medications for opioid use disorder: a systematic review. Addict Sci Clin Pract. 2021;16:62. + + + Australian Bureau of Statistics. Prisoners in Australia Canberra. Canberra: ABS; 2021. Available from: https://www.abs.gov.au/statistics/people/crime-and-justice/prisoners-australia/2021 + + + Australian Institute of Health and Welfare. Profile of Indigenous Australians. Canberra: AIHW, Australian Government; 2020. Available from: https://www.aihw.gov.au/reports/australias-health/profile-of-indigenous-australians + + + Darke S. Self-report among injecting drug users: a review. Drug Alcohol Depend. 1998;51:253-63. + + + Wagner K, Zhong Y, Teshale E, White K, Winstanley EL, Hettema J, et al. Hepatitis C virus infection and polysubstance use among young adult people who inject drugs in a rural county of New Mexico. Drug Alcohol Depend. 2021;220:108527. + + + +
+ + + 36917520 + + 2023 + 03 + 14 + +
+ + 2162-5220 + + + 2023 + Jan + 19 + + + Dermatitis : contact, atopic, occupational, drug + Dermatitis + + North American Contact Dermatitis Group Patch Test Results: 2019-2020. + 10.1089/derm.2022.29017.jdk + + Background: Patch testing is an important diagnostic tool for assessment of allergic contact dermatitis (ACD). Objective: This study documents the North American Contact Dermatitis Group (NACDG) patch testing results from January 1, 2019, to December 31, 2020. Methods: At 13 centers in North America, patients were tested in a standardized manner with a screening series of 80 allergens, and, as indicated, supplemental allergens. Results: Overall, 4121 patients were tested; 2871 (69.7%) had at least 1 positive/allergic patch test reaction and 2095 patients (51.2%) had a primary diagnosis of ACD. The most commonly positive allergens were nickel (18.2%), methylisothiazolinone (MI) (13.8%), fragrance mix (FM) I (12.8%), hydroperoxides of linalool (HPL) (11.1%), and benzisothiazolinone (BIT) (10.4%). Compared with that of 2017-2018, prevalence of top 20 allergens statistically increased for FM I, HPL, BIT, propolis, and hydroperoxides of limonene (3.5%). For the first time, MI positivity did not increase between reporting periods. Approximately one-fifth of patients (20.3%) had ≥1 clinically relevant reaction(s) to allergens/substances not on the NACDG series. Conclusions: The epidemic of MI contact allergy in North America may have reached a plateau. Patch testing using a robust screening series, and supplemental allergens as indicated, is necessary for comprehensive evaluation of ACD. + + + + DeKoven + Joel G + JG + + From the *Division of Dermatology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada. + + + Division of Occupational Health, Unity Health Toronto, St. Michael's Hospital, Toronto, Canada. + + + + Warshaw + Erin M + EM + + Department of Dermatology, Park Nicollet/Health Partners Health Services, Minneapolis, Minnesota, USA. + + + Department of Dermatology, University of Minnesota, Minneapolis, Minnesota, USA. + + + Department of Dermatology, Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota, USA. + + + + Reeder + Margo J + MJ + + Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA. + + + + Atwater + Amber R + AR + + Department of Dermatology, Duke University Medical Center, Durham, North Carolina, USA. + + + + Silverberg + Jonathan I + JI + + Department of Dermatology, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA. + + + + Belsito + Donald V + DV + + Department of Dermatology, Columbia University Irving Medical College, New York, New York, USA. + + + + Sasseville + Denis + D + + Division of Dermatology, McGill University Health Centre, Montréal, Canada. + + + + Zug + Kathryn A + KA + + Department of Dermatology, Geisel School of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, Nebraska, USA. + + + + Taylor + James S + JS + + Department of Dermatology, Cleveland Clinic, Cleveland, Ohio, USA. + + + + Pratt + Melanie D + MD + + Division of Dermatology, University of Ottawa, Ottawa, Canada. + + + + Maibach + Howard I + HI + + Department of Dermatology, University of California San Francisco, San Francisco, California, USA. + + + + Fowler + Joseph F + JF + Jr + + Division of Dermatology, University of Louisville, Louisville, Kentucky, USA. + + + + Adler + Brandon L + BL + + Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. + + + + Houle + Marie-Claude + MC + + Division of Dermatology, Centre Hospitalier Universitaire de Québec, Laval University, Québec, Canada. + + + + Mowad + Christen M + CM + + Division of Dermatology, Geisinger Medical Center, Danville, Pennsylvania, USA. + + + + Botto + Nina + N + + Department of Dermatology, University of California San Francisco, San Francisco, California, USA. + + + + Yu + JiaDe + J + + Department of Dermatology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA. + + + + Dunnick + Cory A + CA + + Department of Dermatology, University of Colorado, Aurora, Colorado, USA. + + + + eng + + Journal Article + + + 2023 + 01 + 19 + +
+ + United States + Dermatitis + 101207335 + 1710-3568 + + IM +
+ + + + 2023 + 3 + 14 + 13 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917520 + 10.1089/derm.2022.29017.jdk + + +
+ + + 36917526 + + 2023 + 03 + 14 + +
+ + 2162-5220 + + + 2023 + Jan + 19 + + + Dermatitis : contact, atopic, occupational, drug + Dermatitis + + Duodenal Stenosis Linked to Drug Reaction With Eosinophilia and Systemic Symptoms. + 10.1089/derm.2022.29001.mdo + + + Douxami + Marion + M + + From the Service de Dermatologie, CHU Lille, Lille, France. + + + + Faure + Emmanuel + E + + Service de Maladies Infectieuses, CHU Lille, Lille, France. + + + + Fievet + Charlotte + C + + From the Service de Dermatologie, CHU Lille, Lille, France. + + + Service de Dermatologie, CH Seclin, Seclin, France. + + + + Buche + Sébastien + S + + From the Service de Dermatologie, CHU Lille, Lille, France. + + + Service de Dermatologie, CH Seclin, Seclin, France. + + + + Azib-Meftah + Selma + S + + From the Service de Dermatologie, CHU Lille, Lille, France. + + + + Cuypers-Tilmant + Aurélie + A + + Centre de Biologie pathologie, Institut de Pathologie, CHU Lille, Lille, France. + + + + Béné + Johana + J + + Centre Régional de Pharmacovigilance, CHU Lille, Lille, France. + + + + Gautier + Sophie + S + + Centre Régional de Pharmacovigilance, CHU Lille, Lille, France. + + + + Staumont-Salle + Delphine + D + + From the Service de Dermatologie, CHU Lille, Lille, France. + + + U1286 Inserm, INFINITE - Institute for Translational Research in Inflammation, Lille, France. + + + + Dezoteux + Frédéric + F + + From the Service de Dermatologie, CHU Lille, Lille, France. + + + U1286 Inserm, INFINITE - Institute for Translational Research in Inflammation, Lille, France. + + + + eng + + Journal Article + + + 2023 + 01 + 19 + +
+ + United States + Dermatitis + 101207335 + 1710-3568 + + IM +
+ + + + 2023 + 3 + 14 + 13 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917526 + 10.1089/derm.2022.29001.mdo + + +
+ + + 36917521 + + 2023 + 03 + 14 + +
+ + 2162-5220 + + + 2023 + Jan + 19 + + + Dermatitis : contact, atopic, occupational, drug + Dermatitis + + Trends in Patch Testing of Black Patients: The Mayo Clinic Decade Experience (January 1, 2011, to December 31, 2020). + 10.1089/derm.2022.29000.aaj + + Background: Trends in patch testing for allergic contact dermatitis (ACD) have not been well characterized in Black patients. Despite similar incidence of ACD in Black and White patients, there are differences in allergen profiles. Understanding patch testing trends in Black patients furthers knowledge that has considerable impact on the management of ACD in the Black population. Objective: The purpose of this study was to review the results of patch testing in Black patients at Mayo Clinic over a decade. Methods: We retrospectively reviewed the results of patch testing to the standard, extended standard, or hairdresser series in 149 Black patients seen at Mayo Clinic (Rochester, MN; Scottsdale, AZ; and Jacksonville, FL) from January 1, 2011, to December 31, 2020. Results: During the 10-year period, 149 Black patients (mean age, 49.2 years [SD, 17.1 years]; female 67.1%) were patch tested at Mayo Clinic to the standard, extended standard, or hairdresser series. Most common sites of dermatitis were generalized (30.9%), hands (18.8%), leg (16.8%), trunk (16.1%), and arm (14.8%). Overall, 109 patients (73.2%) had at least 1 positive reaction and 74 patients (50%) had 2 or more positive reactions. Overall, the 10 allergens with the highest reaction rates (from highest to lowest) identified in our study population were 4-amino-2-hyroxytoluene (33.3%), thimerosal (20.4%), nickel sulfate (18.9%), methylisothiazolinone (16.5%), methyldibromo glutaronitrile (13.4%), methyldibromo glutaronitrile/phenoxyethanol (12.5%), captan (12.5%), carmine (12.5%), methylchloroisothiazolinone/methylisothiazolinone (11.5%), and hydroperoxide of linalool 1% (11.3%). Conclusions: We describe patch test results in Black patients over a decade at Mayo Clinic. The top 10 allergens were preservatives, hair dyes, and fragrances. Differing patterns of allergens may occur in Black patients due to different patterns of exposures related to cultural practices. + + + + Ajayi + Ayodeji + A + + From the Georgetown University School of Medicine, Washington, District of Columbia, USA. + + + Department of Dermatology, Mayo Clinic, Jacksonville, Florida, USA. + + + + Hall + Matthew + M + + Department of Dermatology, Mayo Clinic, Jacksonville, Florida, USA. + + + + Yiannias + James A + JA + + Department of Dermatology, Mayo Clinic, Scottsdale, Arizona, USA. + + + + Killian + Jill M + JM + + Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, USA. + + + + Davis + Mark D P + MDP + + Department of Dermatology, Mayo Clinic, Rochester, Minnesota, USA. + + + + Youssef + Molly J + MJ + + Department of Dermatology, Mayo Clinic, Rochester, Minnesota, USA. + + + + Cantwell + Hafsa M + HM + + Department of Dermatology, Mayo Clinic, Rochester, Minnesota, USA. + + + + Drage + Lisa A + LA + + Department of Dermatology, Mayo Clinic, Rochester, Minnesota, USA. + + + + Sokumbi + Olayemi + O + + Department of Dermatology, Mayo Clinic, Jacksonville, Florida, USA. + + + Department of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, Florida, USA. + + + + eng + + Journal Article + + + 2023 + 01 + 19 + +
+ + United States + Dermatitis + 101207335 + 1710-3568 + + IM +
+ + + + 2023 + 3 + 14 + 13 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917521 + 10.1089/derm.2022.29000.aaj + + +
+ + + 36917524 + + 2023 + 03 + 14 + +
+ + 2162-5220 + + + 2023 + Jan + 19 + + + Dermatitis : contact, atopic, occupational, drug + Dermatitis + + Injection Site Reactions to Monkeypox Vaccine. + 10.1089/derm.2022.0013 + + + Gaspari + Anthony A + AA + + From the Department of Dermatology, Beebe Medical Group, Rehoboth Beach, Delaware, USA. + + + Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. + + + + eng + + Journal Article + + + 2023 + 01 + 19 + +
+ + United States + Dermatitis + 101207335 + 1710-3568 + + IM +
+ + + + 2023 + 3 + 14 + 13 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917524 + 10.1089/derm.2022.0013 + + +
+ + + 36917527 + + 2023 + 03 + 14 + +
+ + 2162-5220 + + + 2023 + Jan + 19 + + + Dermatitis : contact, atopic, occupational, drug + Dermatitis + + Objective Sleep in Atopic Dermatitis: A Meta-Analysis. + 10.1089/derm.2022.29005.mgu + + Background: The evidence regarding objective sleep especially for the sleep architecture in atopic dermatitis (AD) was limited and not well summarized. Objective: To determine the objective sleep in AD patients as well as its confounders. Methods: We searched PubMed/Medline, Embase, and PsycInfo up to May 2021. Case-control studies or cohort studies that recruited AD patients and healthy controls and reported objective sleep parameters assessed by polysomnography or actigraphy were included. Results: A total of 7 studies with 173 AD patients and 122 controls were analyzed. Specifically, AD patients have significantly decreased total sleep time (TST, -13.797 minutes) and sleep efficiency (SE, -5.589%) accompanied by prolonged wake time after sleep onset (WASO, 29.972 minutes) and rapid eye movement sleep latency (31.894 minutes, all P < 0.05). Furthermore, subgroup analyses showed more WASO in severe AD subgroup compared with nonsevere AD subgroup (51.323 minutes vs 20.966 minutes, P = 0.032), less SE in male-majority subgroup compared with female-majority subgroup (-9.443% vs -4.997%, P = 0.018), and less TST in adult subgroup compared with child subgroup (-41.045 vs -4.016 minutes, P = 0.037). Conclusion: Objective sleep was worse in AD patients, especially among patients with severe AD, males, and adults. AD appears to more predispose difficulty in sleep maintenance rather than falling asleep. + + + + Guo + Miaolan + M + + From the Department of Nursing, Shantou University Medical College, Shantou, China. + + + + Su + Jing + J + + From the Department of Nursing, Shantou University Medical College, Shantou, China. + + + + Zheng + Shaoyan + S + + Academic Affairs Office, Shantou University Medical College, Shantou, China. + + + + Chen + Baixin + B + + Department of Sleep Medicine, Shantou University Mental Health Center, Shantou University Medical College, Shantou, China. + + + Sleep Medicine Center, Shantou University Medical College, Shantou, China. + + + + eng + + Journal Article + Review + + + 2023 + 01 + 19 + +
+ + United States + Dermatitis + 101207335 + 1710-3568 + + IM +
+ + + + 2023 + 3 + 14 + 13 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917527 + 10.1089/derm.2022.29005.mgu + + +
+ + + 36917529 + + 2023 + 03 + 14 + +
+ + 2162-5220 + + + 2023 + Jan + 19 + + + Dermatitis : contact, atopic, occupational, drug + Dermatitis + + Association of Adult Atopic Dermatitis Severity With Bacterial, Viral, and Fungal Skin Infections. + 10.1089/derm.2022.29006.jrd + + Background: Little is known about the relationship of atopic dermatitis (AD) severity, phenotype, and persistence on different types of skin infections. Objective: To evaluate the relationship of AD characteristics and skin infections over time in adults. Methods: We performed a prospective dermatology practice-based study (n = 559). History of infection was assessed using questionnaires. AD severity was evaluated using Scoring Atopic Dermatitis (SCORAD), Eczema Area and Severity Index (EASI), Investigator's Global Assessment (IGA), and Patient-reported Global Assessment (PtGA). Results: At baseline, 160 (21.4%) patients reported history of ≥1 skin infection, including 14.3% with bacterial infections. In multivariable repeated measures logistic regression models, ≥1 cutaneous infection was associated with moderate (adjusted odds ratio [95% confidence interval]: 2.67 [1.67-4.28]) and severe (6.35 [3.36-12.01]) versus mild SCORAD; as well as severe SCORAD-itch; moderate and severe versus clear-mild EASI; moderate and severe versus clear-mild PtGA; mild, moderate, and severe versus clear-almost clear IGA. Cutaneous infections were not associated with ichthyosis, palmar hyperlinearity, nummular eczema, cheilitis, or hand eczema. Specific infections varied by AD severity and body site. Persistent moderate-severe disease was associated with higher odds of skin infection. Conclusion: Skin infections were associated with AD severity but not phenotype, and may be mitigated by improved AD severity. + + + + Rios-Duarte + Jorge A + JA + 0000-0002-0596-9158 + + From the Facultad de Medicina, Universidad de los Andes, Bogotá, Colombia. + + + + Silverberg + Jonathan I + JI + 0000-0003-3686-7805 + + Department of Dermatology, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA. + + + + eng + + Journal Article + + + 2023 + 01 + 19 + +
+ + United States + Dermatitis + 101207335 + 1710-3568 + + IM +
+ + + + 2023 + 3 + 14 + 13 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917529 + 10.1089/derm.2022.29006.jrd + + +
+ + + 36917531 + + 2023 + 03 + 14 + +
+ + 2162-5220 + + + 2023 + Jan + 19 + + + Dermatitis : contact, atopic, occupational, drug + Dermatitis + + Tofacitinib, a JAK1/3 Inhibitor As Treatment for Linear IgA Bullous Dermatosis: A Case Report. + 10.1089/derm.2022.29007.bfa + + + Fan + Birao + B + + 1 Department of Dermatology, Peking University First Hospital, Beijing, China. + + + 2 National Clinical Research Center for Skin and Immune Diseases, Beijing, China. + + + 3 Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Beijing, China. + + + + Wang + Mingyue + M + + 1 Department of Dermatology, Peking University First Hospital, 8 Xishiku Street, Xicheng District, Beijing 100034, China. + + + 2 National Clinical Research Center for Skin and Immune Diseases, Beijing, China. + + + 3 Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Beijing, China. wangmy@pku.edu.cn. + + + + eng + + Journal Article + + + 2023 + 01 + 19 + +
+ + United States + Dermatitis + 101207335 + 1710-3568 + + IM +
+ + + + 2023 + 3 + 14 + 13 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917531 + 10.1089/derm.2022.29007.bfa + + +
+ + + 36917528 + + 2023 + 03 + 14 + +
+ + 2162-5220 + + + 2023 + Jan + 24 + + + Dermatitis : contact, atopic, occupational, drug + Dermatitis + + Koebnerization From Insulin Pump and Continuous Glucose Monitor in a Patient With Psoriasis. + 10.1089/derm.2022.29009.cda + + + Dagenet + Caitlyn B + CB + + From the University of Arizona College of Medicine, Tucson, Arizona, USA. + + + + Hamann + Carsten R + CR + + Department of Dermatology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA. + + + Contact Dermatitis Institute, Phoenix, Arizona, USA. + + + HonorHealth Dermatology Residency, Scottsdale, Arizona, USA. + + + + Hamann + Dathan + D + + Contact Dermatitis Institute, Phoenix, Arizona, USA. + + + HonorHealth Dermatology Residency, Scottsdale, Arizona, USA. + + + + eng + + Journal Article + + + 2023 + 01 + 24 + +
+ + United States + Dermatitis + 101207335 + 1710-3568 + + IM +
+ + + + 2023 + 3 + 14 + 13 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917528 + 10.1089/derm.2022.29009.cda + + +
+ + + 36917530 + + 2023 + 03 + 14 + +
+ + 2162-5220 + + + 2023 + Jan + 19 + + + Dermatitis : contact, atopic, occupational, drug + Dermatitis + + Effectiveness of Dupilumab in Pediatric Patient With Prurigo Nodularis-Like Atopic Dermatitis. + 10.1089/derm.2022.29008.yyi + + + Yiling + Yu + Y + + Department of Dermatology, The Fourth School of Medicine Affiliated to Zhejiang Chinese Medical University, Hangzhou Zhejiang, China. + + + + Ali + Kamran + K + + Department of Dermatology, The Fourth School of Medicine Affiliated to Zhejiang Chinese Medical University, Hangzhou, China. + + + + Jiayang + Da + D + + Department of Dermatology, Hangzhou Third People's Hospital, Hangzhou, China. + + + + Qiu + Yunmi + Y + + Department of Dermatology, The Fourth School of Medicine Affiliated to Zhejiang Chinese Medical University, Hangzhou, China. + + + + Kai + Gao + G + + Department of Dermatology, The Fourth School of Medicine Affiliated to Zhejiang Chinese Medical University, Hangzhou, China. + + + + JinPeng + Shan + S + + Department of Dermatology, The Fourth School of Medicine Affiliated to Zhejiang Chinese Medical University, Hangzhou, China. + + + + Tianci + Xie + X + + Department of Dermatology, The Fourth School of Medicine Affiliated to Zhejiang Chinese Medical University, Hangzhou, China. + + + + Min + Chen + C + + Department of Dermatology, The Fourth School of Medicine Affiliated to Zhejiang Chinese Medical University, Hangzhou, China. + + + + Menghua + Li + L + + Department of Dermatology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China. + + + + Liming + Wu + W + + Department of Dermatology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China. limingwu1973@163.com. + + + + eng + + Journal Article + + + 2023 + 01 + 19 + +
+ + United States + Dermatitis + 101207335 + 1710-3568 + + IM +
+ + + + 2023 + 3 + 14 + 13 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917530 + 10.1089/derm.2022.29008.yyi + + +
+ + + 36917544 + + 2023 + 03 + 14 + +
+ + 2162-5220 + + + 2023 + Jan + 19 + + + Dermatitis : contact, atopic, occupational, drug + Dermatitis + + Oleyl Alcohol May Be an Overlooked Allergen in Pimecrolimus Cream. + 10.1089/derm.2022.0082 + eng + + Journal Article + + + 2023 + 01 + 19 + +
+ + United States + Dermatitis + 101207335 + 1710-3568 + + IM +
+ + + + 2023 + 3 + 14 + 13 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917544 + 10.1089/derm.2022.0082 + + +
+ + + 36917533 + + 2023 + 03 + 14 + +
+ + 2162-5220 + + + 2023 + Jan + 19 + + + Dermatitis : contact, atopic, occupational, drug + Dermatitis + + Allergic Contact Dermatitis Secondary to Bandage With Fragrance: A Survey of Ingredients Found in Bandages. + 10.1089/derm.2022.29012.sek + + + Ekstein + Samuel F + SF + + Park Nicollet Contact Dermatitis Clinic, Minneapolis, MN, USA. sam.fr.ekstein@gmail.com. + + + + Han + Joohee + J + + Park Nicollet Contact Dermatitis Clinic, Minneapolis, MN, USA. + + + + Idrogo-Lam + Xander + X + + University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. + + + + Hylwa + Sara + S + + Park Nicollet Contact Dermatitis Clinic, Minneapolis, MN, USA. + + + Department of Dermatology, University of Minnesota, Minneapolis, MN, USA. + + + + eng + + Journal Article + + + 2023 + 01 + 19 + +
+ + United States + Dermatitis + 101207335 + 1710-3568 + + IM +
+ + + + 2023 + 3 + 14 + 13 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917533 + 10.1089/derm.2022.29012.sek + + +
+ + + 36917546 + + 2023 + 03 + 14 + +
+ + 2162-5220 + + + 2023 + Jan + 19 + + + Dermatitis : contact, atopic, occupational, drug + Dermatitis + + Associations Between Shower and Moisturizing Practices with Atopic Dermatitis Severity: A Prospective Longitudinal Cohort Study. + 10.1089/derm.2022.29020.jis + + Background: Evidence-based recommendations for optimal showering/bathing practices are lacking for atopic dermatitis (AD) patients. Objective: To determine longitudinal associations between showering/bathing practices and AD severity in AD patients. Methods: A prospective single-center dermatology practice-based study was performed. Shower/bath frequency and duration, and frequency of applying moisturizers after showering/bathing were evaluated. AD severity was assessed using objective component of Scoring Atopic Dermatitis (o-SCORAD), SCORAD-itch, Eczema Area and Severity Index (EASI), Patient-Oriented Eczema Measure (POEM), and Dermatology Life Quality Index (DLQI). Repeated-measures regression models examined associations of showering/bathing and moisturizing practices with change in AD severity measures over time. Results: Showering/bathing more than daily versus once daily was associated with higher SCORAD-itch, o-SCORAD, EASI, POEM, and DLQI scores; less than daily versus once daily showering/bathing was not associated with any outcomes. Consistent and even inconsistent application of moisturizer after showering/bathing was associated with lower o-SCORAD, EASI, and POEM scores. Showering/bathing duration was not associated with AD outcomes. Severe SCORAD-sleep, o-SCORAD, EASI, and POEM were associated with less adherence to all showering/bathing recommendations. Conclusion: Showering/bathing daily or less frequently and applying moisturizer postshower/bath were associated with lower AD severity; showering/bathing duration was not. Recommendations concerning shower durations may not be necessary when counseling AD patients. + + + + Rakita + Uros + U + + From the *Department of Internal Medicine, Montgomery Campus of the University of Alabama Heersink School of Medicine, Montgomery, Alabama, USA. + + + + Kaundinya + Trisha + T + + Department of Dermatology, Northwestern Feinberg School of Medicine, Chicago, Illinois, USA. + + + + Silverberg + Jonathan I + JI + + Department of Dermatology, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA. + + + + eng + + Journal Article + + + 2023 + 01 + 19 + +
+ + United States + Dermatitis + 101207335 + 1710-3568 + + IM +
+ + + + 2023 + 3 + 14 + 13 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917546 + 10.1089/derm.2022.29020.jis + + +
+ + + 36917542 + + 2023 + 03 + 14 + +
+ + 2162-5220 + + + 2023 + Jan + 19 + + + Dermatitis : contact, atopic, occupational, drug + Dermatitis + + Germline Mosaicism in STAT3: A Pitfall for Genetic Diagnosis, Counseling, and Therapy of Hyper-IgE Syndrome. + 10.1089/derm.2022.0057 + eng + + Journal Article + + + 2023 + 01 + 19 + +
+ + United States + Dermatitis + 101207335 + 1710-3568 + + IM +
+ + + + 2023 + 3 + 14 + 13 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917542 + 10.1089/derm.2022.0057 + + +
+ + + 36917535 + + 2023 + 03 + 14 + +
+ + 2162-5220 + + + 2023 + Jan + 19 + + + Dermatitis : contact, atopic, occupational, drug + Dermatitis + + Management of Atopic Dermatitis During the COVID-19 Pandemic: Key Questions and Review of the Current Evidence. + 10.1089/derm.2022.29019.pwu + + Since the outbreak of COVID-19, management of atopic dermatitis (AD) has been widely discussed. Key issues include the risk of COVID-19 infection and related outcomes in AD patients, the efficacy and safety of COVID-19 vaccination in AD populations, and management of AD in the COVID-19 pandemic. Recent studies have shown that patients with AD have a slightly increased risk of COVID-19 infection but are not associated with a worse outcome than the non-AD population. COVID-19 vaccination is generally effective and safe in patients with AD. However, temporary discontinuation of certain systemic immunomodulatory agents after vaccination is suggested. During the pandemic, continuation of all immunomodulating agents is suggested, but these agents should be paused when patients with AD are infected with COVID-19 until recovery. Further studies are warranted to investigate the long-term interaction between AD and COVID-19 to aid clinical decisions during the pandemic. + + + + Wu + Po-Chien + PC + + From the *Department of Dermatology, Chang Gung Memorial Hospital, Taoyuan City, Taiwan. + + + Research Center of Big Data and Meta-Analysis, Wan Fang Hospital, Taipei Medical University, Taipei City, Taiwan. + + + + Li + Chia-Lun + CL + + Department of Dermatology, Taipei Veterans General Hospital, Taipei City, Taiwan. + + + Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan. + + + + Chang + Yun-Ting + YT + + Department of Dermatology, Taipei Veterans General Hospital, Taipei City, Taiwan. + + + Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan. + + + Department of Dermatology, National Yang Ming Chiao Tung University, Taipei, Taiwan. + + + + Chen + Chih-Chiang + CC + + Department of Dermatology, Taipei Veterans General Hospital, Taipei City, Taiwan. + + + Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan. + + + Department of Dermatology, National Yang Ming Chiao Tung University, Taipei, Taiwan. + + + Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan. + + + + Wu + Chen-Yi + CY + + Department of Dermatology, Taipei Veterans General Hospital, Taipei City, Taiwan. + + + Department of Dermatology, National Yang Ming Chiao Tung University, Taipei, Taiwan. + + + Department of Public Health, Institute of Public Health, National Yang Ming Chiao Tung University, Taipei City, Taiwan. + + + + Ma + Sheng-Hsiang + SH + + Department of Dermatology, Taipei Veterans General Hospital, Taipei City, Taiwan. + + + Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan. + + + + eng + + Journal Article + Review + + + 2023 + 01 + 19 + +
+ + United States + Dermatitis + 101207335 + 1710-3568 + + IM +
+ + + + 2023 + 3 + 14 + 13 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917535 + 10.1089/derm.2022.29019.pwu + + +
+ + + 36917540 + + 2023 + 03 + 14 + +
+ + 2162-5220 + + + 2023 + Jan + 19 + + + Dermatitis : contact, atopic, occupational, drug + Dermatitis + + Bromide-Induced Acneiform Eruption. + 10.1089/derm.2022.0047 + + + Endo + Ruriko + R + + From the *Department of Dermatology, Mito Saiseikai General Hospital, Mito, Japan. + + + Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan. + + + + Tanaka + Ryota + R + 0000-0002-7887-8126 + + From the *Department of Dermatology, Mito Saiseikai General Hospital, Mito, Japan. + + + Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan. + + + + Nomura + Toshifumi + T + + Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan. + + + + eng + + Journal Article + + + 2023 + 01 + 19 + +
+ + United States + Dermatitis + 101207335 + 1710-3568 + + IM +
+ + + + 2023 + 3 + 14 + 13 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917540 + 10.1089/derm.2022.0047 + + +
+ + + 36917541 + + 2023 + 03 + 14 + +
+ + 2162-5220 + + + 2023 + Jan + 19 + + + Dermatitis : contact, atopic, occupational, drug + Dermatitis + + A Review of Monographs in Contact Allergy: Systemic Drugs by Anton de Groot. + 10.1089/derm.2022.0061 + eng + + Journal Article + + + 2023 + 01 + 19 + +
+ + United States + Dermatitis + 101207335 + 1710-3568 + + IM +
+ + + + 2023 + 3 + 14 + 13 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917541 + 10.1089/derm.2022.0061 + + +
+ + + 36917539 + + 2023 + 03 + 14 + +
+ + 2162-5220 + + + 2023 + Jan + 19 + + + Dermatitis : contact, atopic, occupational, drug + Dermatitis + + Exploring the Relationship Between Dermatology Life Quality Index, Eczema Area and Severity Index, and Sleep Numerical Rating Scale and Pruritus Numerical Rating Scale in Patients with Atopic Dermatitis Treated with Dupilumab. + 10.1089/derm.2022.0031 + + Objective: Patients with atopic dermatitis (AD) experience decreased quality of life (QoL). Here we describe the relationship between severity and QoL-related scores in patients with moderate-to-severe AD treated with dupilumab. Patients and Methods: This was a real-life, retrospective, and observational study involving patients with AD treated with dupilumab. Treatment effectiveness was evaluated based on the changes in the eczema area and severity index (EASI), sleep quality numerical rating scale ,and pruritus numerical rating scale (PNRS), as well as the dermatology life quality index (DLQI). The relationship between each of them was analyzed. After the first data collection at baseline, patients were re-evaluated at 3 subsequent follow-ups (4, 8, and 12 months). Results: A total of 52 patients were enrolled in the study. At 4 months, the change in DLQI is more correlated with PNRSs (r = 0.643, P < 0.001) than the other scores considered. At 8 months, however, the change in DLQIs correlates similarly both with PNRSs (r = 0.644, P < 0.001) and with the change in EASIs (r = 0.633, P < 0.001). At 12 months of treatments, however, the trend reverses and the correlation with EASIs becomes higher (r = 0.735, P < 0.001) than PNRSs (r = 0.0.659, P < 0.001). Conclusions: The results of our study show that the reduction in the impact on QoL for AD patients in the first months of therapy with dupilumab correlates more with the control of pruritus than with the disappearance of skin lesions. + + + + Russo + Filomena + F + 0000-0003-2780-7720 + + From the *Department of Medical, Surgical and Neurological Science, Dermatology Section, University of Siena, S. Maria alle Scotte Hospital, Siena, Italy. + + + + Cioppa + Vittoria + V + + From the *Department of Medical, Surgical and Neurological Science, Dermatology Section, University of Siena, S. Maria alle Scotte Hospital, Siena, Italy. + + + + Cartocci + Alessandra + A + + Department of Medical Biotechnology, University of Siena, Siena, Italy. + + + + Piano + Ernesto De + E + + From the *Department of Medical, Surgical and Neurological Science, Dermatology Section, University of Siena, S. Maria alle Scotte Hospital, Siena, Italy. + + + + Taddeucci + Paolo + P + + From the *Department of Medical, Surgical and Neurological Science, Dermatology Section, University of Siena, S. Maria alle Scotte Hospital, Siena, Italy. + + + + Lazzeri + Laura + L + + From the *Department of Medical, Surgical and Neurological Science, Dermatology Section, University of Siena, S. Maria alle Scotte Hospital, Siena, Italy. + + + + Santi + Francesco + F + 0000-0002-5907-7032 + + From the *Department of Medical, Surgical and Neurological Science, Dermatology Section, University of Siena, S. Maria alle Scotte Hospital, Siena, Italy. + + + + Rubegni + Pietro + P + + From the *Department of Medical, Surgical and Neurological Science, Dermatology Section, University of Siena, S. Maria alle Scotte Hospital, Siena, Italy. + + + + eng + + Journal Article + + + 2023 + 01 + 19 + +
+ + United States + Dermatitis + 101207335 + 1710-3568 + + IM +
+ + + + 2023 + 3 + 14 + 13 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917539 + 10.1089/derm.2022.0031 + + +
+ + + 36917532 + + 2023 + 03 + 14 + +
+ + 2162-5220 + + + 2023 + Jan + 19 + + + Dermatitis : contact, atopic, occupational, drug + Dermatitis + + Allergic Contact Dermatitis and Patch Testing in Skin of Color Patients. + 10.1089/derm.2022.29011.abu + + + Burli + Anuk + A + + From the Department of Dermatology, University of California, San Francisco, San Francisco, California, USA. + + + Department of Internal Medicine, Santa Clara Valley Medical Center, 751 S Bascom Ave, San Jose, California, USA. + + + + Vashi + Neelam A + NA + + Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts, USA. + + + + Li + Becky S + BS + + Department of Dermatology, Howard University, Washington, District of Columbia, USA. + + + + Maibach + Howard I + HI + + From the Department of Dermatology, University of California, San Francisco, San Francisco, California, USA. + + + + eng + + Journal Article + Review + + + 2023 + 01 + 19 + +
+ + United States + Dermatitis + 101207335 + 1710-3568 + + IM +
+ + + + 2023 + 3 + 14 + 13 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917532 + 10.1089/derm.2022.29011.abu + + +
+ + + 36917543 + + 2023 + 03 + 14 + +
+ + 2162-5220 + + + 2023 + Jan + 19 + + + Dermatitis : contact, atopic, occupational, drug + Dermatitis + + Patient-Centered Communication Tools for the Patch Test Clinic. + 10.1089/derm.2022.0072 + + Patient-centered communication positively impacts the clinical encounter. Multiple strategies exist to improve communication between providers and their patients; the application and impact of these strategies have been studied in multiple specialties, though little exists regarding communication best practices in the patch test clinic. Because the procedural components of patch testing often span the course of an entire week, effective communication with patients during the patch testing visit is important for not only technical success, but also patient understanding and experience. In this study, we highlight the value of beginning the patch testing visit with clear introductions and agenda setting, improving patient understanding and engagement through methods such as teach backs and cycles of questions and answers that create patient-provider dialogue, and using communication techniques to make expressions of empathy. We provide detailed examples regarding the application of these techniques to the patch testing process, aimed at enhancing the patch testing experience and improving clinical outcomes. Our review exemplifies how dermatologists can leverage communication tools to improve patient satisfaction and outcomes during patch testing. + + + + Montejano + Rubi Danielle + RD + + From the *Department of Internal Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA. + + + + Chattopadhyay + Aheli + A + 0000-0002-3562-6818 + + Department of Dermatology, University of San Francisco, San Francisco, California, USA. + + + + Woodruff + Carina M + CM + + Epiphany Dermatology, Dallas, Texas, USA. + + + + Botto + Nina + N + + Department of Dermatology, University of San Francisco, San Francisco, California, USA. + + + + eng + + Journal Article + Review + + + 2023 + 01 + 19 + +
+ + United States + Dermatitis + 101207335 + 1710-3568 + + IM +
+ + + + 2023 + 3 + 14 + 13 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917543 + 10.1089/derm.2022.0072 + + +
+ + + 36917545 + + 2023 + 03 + 14 + +
+ + 2162-5220 + + + 2023 + Jan + 19 + + + Dermatitis : contact, atopic, occupational, drug + Dermatitis + + Allergic Contact Dermatitis Associated With Religious Practices: Review of the Literature. + 10.1089/derm.2022.29014.ahu + + Allergic contact dermatitis (ACD) may occur secondary to devotional practices in various religions. A systematic review of PubMed was conducted from inception of database to September 9, 2022. Key terms were "contact dermatitis" or "devotional dermatosis" in association with major world religions including "Christianity," "Islam," "Hinduism," "Buddhism," "Sikhism," and "Judaism." Inclusion criteria were determined by presence of a religious practice and associated ACD. Articles referencing other cutaneous reactions such as chemical leukoderma were excluded. In total, 36 of 102 unique articles identified met inclusion criteria. Twenty-two articles referenced Hinduism, 8 referenced Judaism, 5 referenced Islam, 3 referenced Christianity, and 1 article each mentioned Buddhism and Sikhism. Four articles referenced multiple religions. Para-phenylenediamine was the most common contact allergen overall and is found in blackening ingredients mixed with henna for temporary tattoos. Henna tattooing is a cultural practice associated with Hinduism, Islam, and Judaism. Nine unique contact allergens associated with religious practices were identified. Increasing awareness of religious practices that cause ACD will facilitate culturally competent dermatological care. + + + + Hussain + Aamir N + AN + + From the *Dermatology Residency Program, Department of Dermatology, MedStar Washington Hospital Center/Georgetown University. + + + + Khanna + Rayva + R + + Internal Medicine Residency Program, Department of Dermatology, MedStar Washington Hospital Center. + + + + Moshell + Alan N + AN + + Department of Dermatology, MedStar Washington Hospital Center/Georgetown University. + + + + eng + + Journal Article + Review + + + 2023 + 01 + 19 + +
+ + United States + Dermatitis + 101207335 + 1710-3568 + + IM +
+ + + + 2023 + 3 + 14 + 13 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917545 + 10.1089/derm.2022.29014.ahu + + +
+ + + 36917538 + + 2023 + 03 + 14 + +
+ + 2162-5220 + + + 2023 + Jan + 19 + + + Dermatitis : contact, atopic, occupational, drug + Dermatitis + + Successful Treatment of Atopic Hand and Foot Eczema With Oral Janus Kinase 1 Inhibition. + 10.1089/derm.2022.0030 + eng + + Journal Article + + + 2023 + 01 + 19 + +
+ + United States + Dermatitis + 101207335 + 1710-3568 + + IM +
+ + + + 2023 + 3 + 14 + 13 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917538 + 10.1089/derm.2022.0030 + + +
+ + + 36917537 + + 2023 + 03 + 14 + +
+ + 2162-5220 + + + 2023 + Jan + 19 + + + Dermatitis : contact, atopic, occupational, drug + Dermatitis + + Dermatitis Venenata: Then and Now. + 10.1089/derm.2022.0029 + + + Arora + Neha + N + 0000-0001-6452-7598 + + From the *Texas A&M University School of Medicine Department of Dermatology, Bryan, Texas, USA. + + + + Griffin + John R + JR + + Adjunct Clinical Assistant Professor of Medical Education, Department of Dermatology, Texas A&M University School of Medicine, Houston, Texas, USA. + + + Department of Dermatology, Kelsey-Seybold Clinic, Houston, Texas, USA. + + + + eng + + Journal Article + + + 2023 + 01 + 19 + +
+ + United States + Dermatitis + 101207335 + 1710-3568 + + IM +
+ + + + 2023 + 3 + 14 + 13 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917537 + 10.1089/derm.2022.0029 + + +
+ + + 36917534 + + 2023 + 03 + 14 + +
+ + 2162-5220 + + + 2023 + Jan + 19 + + + Dermatitis : contact, atopic, occupational, drug + Dermatitis + + Patch Testing With Benzophenone-3 and -4: The North American Contact Dermatitis Group Experience, 2013-2020. + 10.1089/derm.2022.29013.ewa + + Background: Benzophenone (BZP)-3 and BZP-4 are ultraviolet (UV) absorbers used in sunscreens and personal care products (PCPs) and may cause allergic contact dermatitis. Objective: To characterize positive patch test reactions to BZP-3 (10% in petrolatum [pet]) and BZP-4 (2% pet) in a screening allergen series. Methods: Retrospective analysis of patients tested to BZP-3 and BZP-4 was conducted by the North American Contact Dermatitis Group from 2013 to 2020. Results: Of 19,618 patients patch tested to BZP-3 and BZP-4, 103 (0.5%) and 323 (1.6%) had positive reactions, respectively: 413 (2.1%) reacted to at least 1 BZP (BZP-positive patient). As compared with BZP-negative patients, BZP-positive patients were significantly more likely to have a history of hay fever (39.3% vs 33.4%, P = 0.0134), history of atopic dermatitis (39.8% vs 30.7%, P = 0.0001), and facial involvement (37.4% vs 32.2%, P = 0.0272). Most reactions were currently clinically relevant (BZP-3: 90.4%; BZP-4: 65.8%). Common identified sources included PCPs and sunscreens. Coreactivity between BZP-3 and BZP-4 was low: 13.5% (14/104) of BZP-3-positive patients were allergic to BZP-4 and 4.3% (14/322) of BZP-4-positive patients were allergic to BZP-3. Conclusions: Eight-year prevalence of BZP positivity was 2.1%. Reactions were frequently clinically relevant and linked to PCPs and sunscreens. + + + + Warshaw + Erin M + EM + + From the Department of Dermatology, Park Nicollet/Health Partners Health Services, Minneapolis, Minnesota, USA. + + + Department of Dermatology, University of Minnesota, Minneapolis, Minnesota, USA. + + + Department of Dermatology, Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota, USA. + + + + Xiong + Michelle + M + + From the Department of Dermatology, Park Nicollet/Health Partners Health Services, Minneapolis, Minnesota, USA. + + + Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA. + + + + Belsito + Donald V + DV + + Department of Dermatology, Columbia University Irving Medical School, New York, New York, USA. + + + + Adler + Brandon L + BL + + Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. + + + + Atwater + Amber R + AR + + Department of Dermatology, Duke University Medical Center, Durham, North Carolina, USA. + + + + DeKoven + Joel G + JG + + Division of Dermatology, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada. + + + + Taylor + James S + JS + + Department of Dermatology, Cleveland Clinic, Cleveland, Ohio, USA. + + + + Reeder + Margo J + MJ + + Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA. + + + + Houle + Marie-Claude + MC + + Division of Dermatology, Centre Hospitalier Universitaire de Québec, Laval University, Québec, Canada. + + + + Silverberg + Jonathan I + JI + + Department of Dermatology, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA. + + + + Pratt + Melanie D + MD + + Division of Dermatology, University of Ottawa, Ontario, Canada. + + + + Dunnick + Cory A + CA + + Department of Dermatology, University of Colorado, Aurora, Colorado, USA. + + + + Botto + Nina + N + + Department of Dermatology, University of California San Francisco, San Francisco, California, USA. + + + + DeLeo + Vincent A + VA + + Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. + + + + Mowad + Christen M + CM + + Division of Dermatology, Geisinger Medical Center, Danville, Pennsylvania, USA. + + + + Maibach + Howard I + HI + + Department of Dermatology, University of California San Francisco, San Francisco, California, USA. + + + + Yu + JiaDe + J + + Department of Dermatology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA. + + + + Fowler + Joseph F + JF + + Division of Dermatology, University of Louisville, Louisville, Kentucky, USA. + + + + eng + + Journal Article + Review + + + 2023 + 01 + 19 + +
+ + United States + Dermatitis + 101207335 + 1710-3568 + + IM +
+ + + + 2023 + 3 + 14 + 13 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917534 + 10.1089/derm.2022.29013.ewa + + +
+ + + 36917556 + + 2023 + 03 + 14 + +
+ + 1533-4023 + + + 2023 + Mar + 13 + + + Journal of cardiovascular pharmacology + J Cardiovasc Pharmacol + + Non-alcoholic fatty liver disease as an emerging risk factor and potential intervention target for atherosclerotic cardiovascular diseases. + 10.1097/FJC.0000000000001418 + + Non-alcoholic fatty liver disease (NAFLD) is an underappreciated independent risk factor for atherosclerotic cardiovascular diseases (ASCVDs). In recent years, the risk of ASCVD has increased along with the prevalence of NAFLD. ASCVD events are highly prevalent and are the main contributor to death in patients with NAFLD. The association between NAFLD and ASCVD has been validated in numerous observational, cohort, and genetic studies. Most of these studies agree that NAFLD significantly increases the risk of developing atherosclerosis and ASCVD. Additionally, the underlying pro-atherosclerotic mechanisms of NAFLD have been gradually revealed, both disorders share several common pathophysiologic mechanisms including insulin resistance, while systemic inflammation and dyslipidemia driven by NAFLD directly promote atherosclerosis. Recently, NAFLD, as an emerging risk enhancer for ASCVD, has attracted attention as a potential treatment target for ASCVD. This brief review aims to illustrate the potential mechanistic insights, present recent clinically relevant investigations, and further explore the emerging therapies such as novel anti-diabetic and lipid-lowering agents that could improve NAFLD and reduce ASCVD risk. + Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. + + + + Zhang + Daqing + D + + Department of Cardiology, Shengjing Hospital of China Medical University, No.36, Sanhao Street, Heping District, Shenyang City 110004, Liaoning Province, PR China. + + + + Mi + Zhen + Z + + Department of Cardiology, Shengjing Hospital of China Medical University, No.36, Sanhao Street, Heping District, Shenyang City 110004, Liaoning Province, PR China. + + + + Peng + Jiya + J + + Department of Cardiology, Shengjing Hospital of China Medical University, No.36, Sanhao Street, Heping District, Shenyang City 110004, Liaoning Province, PR China. + + + + Yang + Tiangui + T + + Department of Cardiology, Shengjing Hospital of China Medical University, No.36, Sanhao Street, Heping District, Shenyang City 110004, Liaoning Province, PR China. + + + + Han + Yuze + Y + + Department of Cardiology, Shengjing Hospital of China Medical University, No.36, Sanhao Street, Heping District, Shenyang City 110004, Liaoning Province, PR China. + + + Department of Cardiology, Dalian Friendship Hospital, Dalian City, 116001, Liaoning Province, PR China. + + + + Zhai + Yujia + Y + + Department of Cardiology, Shengjing Hospital of China Medical University, No.36, Sanhao Street, Heping District, Shenyang City 110004, Liaoning Province, PR China. + + + + Song + Chenliang + C + + Department of Cardiology, Shengjing Hospital of China Medical University, No.36, Sanhao Street, Heping District, Shenyang City 110004, Liaoning Province, PR China. + + + + Teng + Xianzhuo + X + + Department of Cardiology, Shengjing Hospital of China Medical University, No.36, Sanhao Street, Heping District, Shenyang City 110004, Liaoning Province, PR China. + + + + Sun + Wei + W + + Department of Cardiology, Shengjing Hospital of China Medical University, No.36, Sanhao Street, Heping District, Shenyang City 110004, Liaoning Province, PR China. + + + Department of Cardiology, Dalian Third People's Hospital, Dalian City, 116000, Liaoning Province, PR China. + + + + Guo + Jing + J + + Department of Cardiology, Shengjing Hospital of China Medical University, No.36, Sanhao Street, Heping District, Shenyang City 110004, Liaoning Province, PR China. + + + + Bilonda + Kabeya Paulin + KP + + Department of Cardiology, Shengjing Hospital of China Medical University, No.36, Sanhao Street, Heping District, Shenyang City 110004, Liaoning Province, PR China. + + + + eng + + Journal Article + + + 2023 + 03 + 13 + +
+ + United States + J Cardiovasc Pharmacol + 7902492 + 0160-2446 + + IM + The authors declare no conflicts of interest. +
+ + + + 2023 + 3 + 14 + 13 + 22 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917556 + 10.1097/FJC.0000000000001418 + 00005344-990000000-00162 + + +
+ + + 36917536 + + 2023 + 03 + 14 + +
+ + 2162-5220 + + + 2023 + Jan + 19 + + + Dermatitis : contact, atopic, occupational, drug + Dermatitis + + Allergic Contact Dermatitis in the Older Adults: A Comparative Cross-Sectional Study. + 10.1089/derm.2022.0004 + + Background: Allergic contact dermatitis (ACD) is a significant health problem in older adults. Reports in the literature regarding the prevalence of ACD in older adults are various and inconsistent. In contrast, the data regarding contact irritant dermatitis are more consistent. Objective: To compare ACD characteristics in older adults versus the adult population aged 18-45 years. Methods: We conducted a retrospective controlled study. Data were obtained from the medical records of 4199 patients. We collected information regarding age, gender, atopic diathesis, anatomical distribution of the rash, reactions to patch tests, and final diagnosis. Results: The frequency of positive reactions in patch testing was lower in the older adult group than in the younger population, but the frequency of clinically relevant positive reactions was higher in the older adults. There was no statistically significant difference in the final diagnosis of ACD between the groups. The most common allergens among the older adult population were fragrance mix, preservatives (Methylchloroisothiazolinone/methylisothiazolinone [MCI/MI]), and nickel sulfate. Conclusion: This study, the first of its kind in Israel to include a large group of older adult patients, contributes to a better understanding of clinical parameters related to ACD among older adults. Consequently, it will hopefully contribute to lowering the disease burden. + + + + Slodownik + Dan + D + 0000-0001-6560-2625 + + From the *Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. + + + Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel. + + + + Mousa + Maria + M + + Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel. + + + + Bar + Jonathan + J + + From the *Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. + + + Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel. + + + + eng + + Journal Article + + + 2023 + 01 + 19 + +
+ + United States + Dermatitis + 101207335 + 1710-3568 + + IM +
+ + + + 2023 + 3 + 14 + 13 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917536 + 10.1089/derm.2022.0004 + + +
+ + + 36917549 + + 2023 + 03 + 14 + +
+ + 1520-5827 + + + 2023 + Mar + 14 + + + Langmuir : the ACS journal of surfaces and colloids + Langmuir + + Bioactives Promiscuity of Mucin: Insight from Multi-Spectroscopic, Thermodynamic, and Molecular Dynamic Simulation Analyses. + 10.1021/acs.langmuir.2c03268 + + Mucosal drug delivery plays an increasing role in the clinical setting owing to mucin's advantageous biochemical and pharmacological properties. However, how this transport system recognizes different substrates remains unclear. In this study, we explore the mechanism of bioactive (quercetin and berberine) promiscuity of mucin using various spectroscopic techniques and molecular dynamics simulations. The UV-visible spectroscopy results and the decreased fluorescence intensity of mucin in the presence of the bioactive compounds via a static quenching mechanism confirmed ground-state complex formation between the bioactives and mucin. The binding constants (Kb) were evaluated at different temperatures to afford Kb values of ∼104 Lmol-1, demonstrating the moderate and reasonable affinity of the bioactives for mucin, yielding greater diffusion into the tissues. Thermodynamic analysis and molecular dynamics (MD) simulations demonstrate that mucin-bioactive complex formation occurs primarily because of electrostatic/ionic interactions, while hydrophobic interactions were also crucial in stabilizing the complex. Far-UV circular dichroism spectroscopy showed that bioactive binding induced secondary structural changes in mucin. Sitemap and MD simulation indicated the principal binding site of mucin for the bioactives. This study also provides insight into the bioactives promiscuity of mucin in the presence of a crowded environment, which is relevant to the biological activity of mucin in vivo. An in vitro drug release study revealed that crowding assisted drug release in an enhanced burst manner compared with that in a dilute buffer system. This work thus provides fresh insight into drug absorption and distribution in the native cellular environment and helps direct new drug design and use in pharmaceutical and pharmacological fields. + + + + Kumari + Komal + K + + Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh 221005, India. + + + + Kumar + Avinash + A + 0000-0003-3815-1050 + + Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, MAHE, Madhav Nagar, Manipal, Karnataka 576104, India. + + + + Manjur + Ahamad Tamanna + AT + + Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh 221005, India. + + + + Rakshit + Surajit + S + 0000-0002-2739-4404 + + Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh 221005, India. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Langmuir + 9882736 + 0743-7463 + + IM +
+ + + + 2023 + 3 + 14 + 13 + 12 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917549 + 10.1021/acs.langmuir.2c03268 + + +
+ + + 36917550 + + 2023 + 03 + 14 + +
+ + 2042-3306 + + + 2023 + Mar + 14 + + + Equine veterinary journal + Equine Vet J + + Towards a safer sport: Risk factors for cross-country horse falls at British Eventing competition. + 10.1111/evj.13934 + + Equestrian eventing is a dangerous Olympic sport, with 16 rider and 69 horse fatalities at competition in the last 10 years. Despite this, there is limited research that aims to improve safety within the sport. + The purpose of this study was to identify risk factors for horse falls, which are the leading cause of rider fatality within the sport. + Retrospective cohort study. + Competition data between January 2005 and December 2015 were analysed. Descriptive statistics followed by univariable logistic regression to identify risk factors for inclusion in a multivariable logistic regression model were conducted. Models were constructed stepwise using a bi-directional process and assessed using the Akaike Information Criterion. A total of 749 534 cross-country starts were analysed for association with the risk of horse falls. + Sixteen risk factors were identified including: higher event levels, higher dressage penalties and higher number of days since horses' last start. For example, horse and rider combinations competing at BE100 (OR 1.64, CI 1.37-1.96, p < 0.001), Novice (OR 3.58, CI 3.03-4.24, p < 0.001), Intermediate (OR 8.00, CI 6.54-9.78, p < 0.001), Advanced (OR 12.49, CI 9.42-16.57, p < 0.001) and International (OR 4.63, CI 3.50-6.12, p < 0.001) all had a higher risk of having a horse fall in comparison to combinations competing at BE90 level. Furthermore, for every additional 10 dressage penalties awarded to a horse and rider combination, there was a higher risk of a horse fall (OR 1.20, CI 1.12-1.28, p < 0.001). + The study is not geographically comprehensive (UK only) and does not include any information on training activity of horses and riders. + This is the largest-scale study ever conducted on horse falls during eventing competition. Study results can be utilised by sport governing bodies to inform policy which has the potential to reduce the risk of injury and fatality to sport participants. This article is protected by copyright. All rights reserved. + This article is protected by copyright. All rights reserved. + + + + Cameron-Whytock + Heather A + HA + https://orcid.org/0000-0003-0760-2584 + + School of Animal Rural and Environmental Science, Nottingham Trent University, Brackenhurst Campus, Southwell, Nottinghamshire, NG25 0QF, UK. + + + Research Centre for Applied Sport, Physical Activity and Performance, University of Central Lancashire, Preston, Lancashire, PR1 2HE, UK. + + + University Centre Myerscough, St Michaels Road, Bilsborrow, Preston, Lancashire, PR3 0RY, UK. + + + + Parkin + Tim D H + TDH + https://orcid.org/0000-0003-3566-9030 + + Bristol Veterinary School, University of Bristol, Langford, Bristol, BS40 5DU, UK. + + + + Hobbs + Sarah J + SJ + https://orcid.org/0000-0002-1552-8647 + + Research Centre for Applied Sport, Physical Activity and Performance, University of Central Lancashire, Preston, Lancashire, PR1 2HE, UK. + + + + Brigden + Charlotte V + CV + + University Centre Myerscough, St Michaels Road, Bilsborrow, Preston, Lancashire, PR3 0RY, UK. + + + + Bennet + Euan D + ED + https://orcid.org/0000-0001-9049-1920 + + School of Veterinary Medicine, University of Glasgow, Glasgow, G61 1QH, UK. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Equine Vet J + 0173320 + 0425-1644 + + IM + + epidemiology + equestrian sport + eventing + fatality + horse + injury + risk + +
+ + + + 2022 + 09 + 09 + + + 2023 + 03 + 08 + + + 2023 + 3 + 14 + 13 + 12 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917550 + 10.1111/evj.13934 + + +
+ + + 36917555 + + 2023 + 03 + 14 + +
+ + 1520-5215 + + + 2023 + Mar + 14 + + + The journal of physical chemistry. A + J Phys Chem A + + Comparison of Implicit and Explicit Solvent Approaches in Ab Initio Evaluation of Thermochemistry in Solution: Application in Studying Boron Isotope Fractionation in Water. + 10.1021/acs.jpca.3c00154 + + Evaluation of thermochemistry in solution plays a key role in numerous fields. For this task, the solvent effects are commonly included in theoretical computations based on either implicit or explicit solvent approaches. In the present study, we evaluate and compare the performance of some of the most widely applied methods based on these two approaches. For studying the solvent effect on thermochemistry with an explicit solvent, we demonstrate that partial normal mode analysis with frozen geometry of solvent molecules for multiple solute-solvent configurations can yield quite accurate and reliable results for a drastically reduced computational cost. As a case study, we consider the evaluation of the equilibrium constant for the boron isotope exchange between boric acid and borate (k3-4) in pure and saline water which is of high geochemical importance. Employing three different rigorous and high-precision theoretical approaches, we provide a reliable estimation of k3-4 which is a value within 1.028 to 1.030 for both pure and saline water which is in excellent agreement with experimental data. + + + + Alibakhshi + Amin + A + 0000-0003-3880-5974 + + Theoretical Chemistry, Institute for Physical Chemistry, Christian-Albrechts-University, Olshausenstr. 40, 24118 Kiel, Germany. + + + Theoretical Chemistry, Ruhr-Universitaet Bochum, D-44780 Bochum, Germany. + + + + Steffen + Julien + J + + Theoretical Chemistry, Institute for Physical Chemistry, Christian-Albrechts-University, Olshausenstr. 40, 24118 Kiel, Germany. + + + + Pinilla + Carlos + C + + Departamento de Física y Geociencias, Universidad del Norte, Km 5 via Puerto Colombia, Barranquilla 080020, Colombia. + + + School of Chemistry, University of Bristol, Cantock's Close Road, BS8 1TS Bristol, U.K. + + + + Hartke + Bernd + B + 0000-0001-8480-0862 + + Theoretical Chemistry, Institute for Physical Chemistry, Christian-Albrechts-University, Olshausenstr. 40, 24118 Kiel, Germany. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + J Phys Chem A + 9890903 + 1089-5639 + + IM +
+ + + + 2023 + 3 + 14 + 13 + 22 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917555 + 10.1021/acs.jpca.3c00154 + + +
+ + + 36917558 + + 2023 + 03 + 14 + +
+ + 1520-5126 + + + 2023 + Mar + 14 + + + Journal of the American Chemical Society + J Am Chem Soc + + Directing Group Repositioning Strategy Enabled Site- and Enantioselective Addition of Heteroaromatic C-H Bonds to Acyclic Internal Alkenes. + 10.1021/jacs.3c00095 + + Despite the notable advances achieved in the Murai-type hydroarylations, highly enantioselective catalytic addition of native (hetero)arenes to internal alkenes remains a prominent challenge. Herein, we report a directing group repositioning strategy, which enables the iridium-catalyzed enantioselective addition of heteroarenes including furan, benzofuran, and thiophene to internal enamides. The C-H bond at the C2 position of the heteroarene is site-selectively cleaved and added regioselectively to the β-position of an enamide, affording a valuable β-heteroaryl amide with high enantioselectivity. Mechanistic studies indicate that the rate and the enantioselectivity are determined by separate elementary steps. + + + + Zhao + Wei + W + + Center of Basic Molecular Science (CBMS), Department of Chemistry, Tsinghua University, Beijing 100084, China. + + + + Li + Bi-Jie + BJ + 0000-0001-8528-8514 + + Center of Basic Molecular Science (CBMS), Department of Chemistry, Tsinghua University, Beijing 100084, China. + + + State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + J Am Chem Soc + 7503056 + 0002-7863 + + IM +
+ + + + 2023 + 3 + 14 + 13 + 22 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917558 + 10.1021/jacs.3c00095 + + +
+ + + 36917551 + + 2023 + 03 + 14 + +
+ + 2042-3306 + + + 2023 + Mar + 14 + + + Equine veterinary journal + Equine Vet J + + Treatment of Equine Sarcoids: a systematic review. + 10.1111/evj.13935 + + The sarcoid is the most common equine cutaneous neoplasm. Evidence-based treatment of this condition is often lacking, and selection of treatment modality based on clinical experience or anecdotal evidence. + To assess the quality of the currently available best evidence regarding the treatment of the equine sarcoid. + Systematic review. + In compliance with PRISMA guidelines, literature searches were performed in PUBMED, Web of Science, CAB Abstracts, EMBASE (Ovid) and Scopus in April 2021. Included papers were required to describe an interventional study examining sarcoid treatment strategy, of level 4 evidence or greater. The case definition required confirmation of at least some included lesions on histopathology, and a minimum of 6 months of follow up was required on treated cases. Studies were assessed by two independent reviewers (KO, CD). Data extraction was performed manually, followed by risk of bias assessment. Methodological quality was assessed using the GRADE system. + In total, ten studies were included in the review. Case definition was confirmed via histopathology in all included lesions in 60% of papers. Time to follow up was variably reported. Overall risk of bias ranged from 'some concerns' to 'critical'. Reported sarcoid regression rate ranged from 28-100% on an individual sarcoid level, and 9-100% on a whole horse level. Transient local inflammation was reported following most treatment strategies, with further adverse events reported infrequently. + eview methodology excluded a large proportion of available literature regarding the equine sarcoid. Significant heterogeneity between included studies prevented quantitative synthesis and most included papers were at significant risk of bias, indirectness, and imprecision. + There is insufficient evidence currently available to recommend one sarcoid treatment over another. There is an urgent need for sufficiently powered, randomised, placebo-controlled trials in order to allow more definitive comparison of the efficacy of different treatment strategies. + This article is protected by copyright. All rights reserved. + + + + Offer + Katie S + KS + https://orcid.org/0000-0003-1608-212X + + School of Biodiversity, One Health and Veterinary Medicine, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. + + + + Dixon + Claire E + CE + https://orcid.org/0000-0001-9927-3276 + + School of Biodiversity, One Health and Veterinary Medicine, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. + + + + Sutton + David G M + DGM + https://orcid.org/0000-0002-7241-8444 + + School of Biodiversity, One Health and Veterinary Medicine, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. + + + + eng + + Journal Article + Review + + + 2023 + 03 + 14 + +
+ + United States + Equine Vet J + 0173320 + 0425-1644 + + IM +
+ + + + 2022 + 11 + 24 + + + 2023 + 03 + 09 + + + 2023 + 3 + 14 + 13 + 12 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917551 + 10.1111/evj.13935 + + +
+ + + 36917557 + + 2023 + 03 + 14 + +
+ + 1520-5126 + + + 2023 + Mar + 14 + + + Journal of the American Chemical Society + J Am Chem Soc + + Selective Cleavage of the Strong or Weak C-C Bonds in Biphenylene Enabled by Rare-Earth Metals. + 10.1021/jacs.3c01466 + + Selective cleavage of C-C bonds within arene rings is of great interest but remains elusive, especially for the molecules possessing the active and inert C-C bonds. Here, we report that the active and inert C-C bonds of biphenylene could be controllably cleaved by the reaction of biphenylene, potassium graphite, and rare-earth complexes with different metal centers. For scandium, the bond activation occurs at the Caryl-Caryl single bond, yielding 9-scandafluorene. For Lu, the reaction goes through ring contraction of the aromatic ring in biphenylene to provide benzopentalene dianionic lutetium. The origin of the selectivity and the reaction mechanism were illustrated by the isolation of intermediates and DFT calculations. + + + + Zhu + Miaomiao + M + 0000-0001-7306-0336 + + Beijing National Laboratory for Molecular Sciences (BNLMS), State Key Laboratory of Rare-earth Materials Chemistry and Applications & Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China. + + + + Chai + Zhengqi + Z + 0000-0003-2151-1507 + + Beijing National Laboratory for Molecular Sciences (BNLMS), State Key Laboratory of Rare-earth Materials Chemistry and Applications & Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China. + + + + Lv + Ze-Jie + ZJ + 0000-0003-1994-8400 + + Beijing National Laboratory for Molecular Sciences (BNLMS), State Key Laboratory of Rare-earth Materials Chemistry and Applications & Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China. + + + + Li + Tianyu + T + 0000-0002-6389-9282 + + Beijing National Laboratory for Molecular Sciences (BNLMS), State Key Laboratory of Rare-earth Materials Chemistry and Applications & Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China. + + + + Liu + Wei + W + 0000-0002-2542-0621 + + Beijing National Laboratory for Molecular Sciences (BNLMS), State Key Laboratory of Rare-earth Materials Chemistry and Applications & Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China. + + + + Wei + Junnian + J + 0000-0001-9733-803X + + Beijing National Laboratory for Molecular Sciences (BNLMS), State Key Laboratory of Rare-earth Materials Chemistry and Applications & Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China. + + + + Zhang + Wen-Xiong + WX + 0000-0003-0744-2832 + + Beijing National Laboratory for Molecular Sciences (BNLMS), State Key Laboratory of Rare-earth Materials Chemistry and Applications & Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + J Am Chem Soc + 7503056 + 0002-7863 + + IM +
+ + + + 2023 + 3 + 14 + 13 + 22 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917557 + 10.1021/jacs.3c01466 + + +
+ + + 36917547 + + 2023 + 03 + 14 + +
+ + 1526-7598 + + + 2023 + Mar + 14 + + + Anesthesia and analgesia + Anesth Analg + + Components of General Anesthesia: History of the Concept Transformation. + 10.1213/ANE.0000000000006454 + + The concept that the state of general anesthesia consists of a number of components representing the distinct and desired central effects of general anesthetics was formulated when it was common to believe that all components of anesthesia have a lipid-centered mechanism of action. The transformation of this concept was associated with changes in our understanding of the mechanisms underlying general anesthetic action. First came the shift from a lipid- to a protein-centered mechanism of action, which opened the way to various molecular targets associated with general anesthesia. Then, it was found that different components of anesthesia may have completely different underlying mechanisms, such as blockade of movement in response to noxious stimulation by isoflurane centers at the spinal cord level, not at the brain, as is the case with other components. The chain of discoveries associated with newfound differences between components of anesthesia accompanied general progress toward a more comprehensive understanding of the mechanism of action of general anesthetics, including anesthetic binding sites, details of receptors and ion channels involved in neurotransmission, and the critical role of neuronal networks. There are several important consequences of our improved understanding. First, a single measurement of anesthetic depth (eg, minimum alveolar concentration index [MAC index]) might not be appropriate for the different component of anesthesia. Second, because the mechanism of action of the components varies, synergy for 1 component does not exclude an additive effect or even antagonism for another component. + Copyright © 2023 International Anesthesia Research Society. + + + + Kissin + Igor + I + + From the Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Anesth Analg + 1310650 + 0003-2999 + + IM + The author declares no conflicts of interest. +
+ + + + 2023 + 3 + 14 + 13 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917547 + 10.1213/ANE.0000000000006454 + 00000539-990000000-00528 + + + + Woodbridge PD. Changing concepts concerning depth of anesthesia. Anesthesiology. 1957;18:536–550. + + + Pinsker MC. Anesthesia: a pragmatic construct. Anesth Analg. 1986;65:819–820. + + + Prys-Roberts C. Anaesthesia: a practical or impractical construct? Br J Anaesth. 1987;59:1341–1345. + + + Guedel AE. Inhalation Anesthesia: A Fundamental Guide. Macmillan, 1937:14–60. + + + Agard WR, Howe HM. Medical Greek and Latin at a Glance. 2nd ed. Paul B. Hober; 1937 + + + Franks NP. Molecular targets underlying general anaesthesia. Br J Pharmacol. 2006;147:S72–S81. + + + Franks NP, Lieb WR. Do general anaesthetics act by competitive binding to specific receptors? Nature. 1984;310:599–601. + + + Kissin I. General anesthetic action: an obsolete notion. Anesth Analg. 1993;76:215–218. + + + Rampil IJ, Mason P, Singh H. Anesthetic potency (MAC) is independent of forebrain structures in the rat. Anesthesiology. 1993;78:707–712. + + + Antognini JF, Schwartz K. Exaggerated anesthetic requirements in the preferentially anesthetized brain. Anesthesiology. 1993;79:1244–1249. + + + Warren JC. Etherization With Surgical Remarks. William D. Ticknor, 1847. + + + Kelz MB, Mashour GA, Abel TG, Maze M. Sleep, memory, and consciousness. In: Miller RD, ed. Miller’s Anesthesia. 7th ed. Elsevier, 2010:237–259. + + + Evers AS, Crowder CM, Balser JR. General anesthetics. In: Brunton LL, ed. Goodman and Gilman’s The Pharmacological Basis of Therapeutics. 11th ed. McGraw Hill Medical, 2006:341–368. + + + Raja SN, Carr DB, Cohen M, et al. The revised international association for study of pain definition of pain: concepts, challenges, and compromises. Pain. 2020;161:1976–1982. + + + Kissin I. Analgesia as a component of general anesthesia: a problem of terminology? Anesthesiology. 2023;138:122–123. + + + Kissin I, Gelman S. Components of anaesthesia. Br J Anaesth. 1988;61:237–238. + + + Brown EN, Pavone KJ, Naranjo M. Multimodal general anesthesia: theory and practice. Anesth Analg. 2018;127:1246–1258. + + + Hemmings HC Jr, Riegelhaupt PM, Kelz MB, et al. Towards a comprehensive understanding of anesthetic mechanisms of action: a decade of discovery. Trends Pharmacol Sci. 2019;40:464–481. + + + Weir CJ, Mitchell SJ, Lambert JJ. Role of GABA A receptor subtypes in the behavioural effects of intravenous general anesthetics. Br J Anaesth. 2017;119:i167–i175. + + + Martin LJ, Zurek AA, MacDonald JF, Roder JC, Jackson MF, Orser BA. Alpha5GABAA receptor activity sets the threshold for long-term potentiation and constrains hippocampus-dependent memory. J Neurosci. 2010;30:5269–5282. + + + Martin LJ, Oh GHT, Orser BA. Etomidate targets alpha5 gamma-aminobutyric acid subtype A receptors to regulate synaptic plasticity and memory blockade. Anesthesiology. 2009;111:1025–1035. + + + Cheng VY, Martin LJ, Elliott EM, et al. Alpha5GABAA receptors mediate the amnestic but not sedative-hypnotic effects of the general anesthetic etomidate. J Neurosci. 2006;26:3713–3720. + + + Van Den Heuvel MP, Sporns O. Rich-club organization of the human connectome. J Neurosci. 2011;31:15775–15786. + + + Alkire MT, Hudetz AG, Tononi G. Consciousness and anesthesia. Science. 2008;322:876–880. + + + Boveroux P, Vanhaudenhuyse A, Bruno MA, et al. Breakdown of within- and between-network resting state functional magnetic resonance imaging connectivity during propofol-induced loss of consciousness. Anesthesiology. 2010;113:1038–1053. + + + Manshour GA. Top-down mechanisms of anesthetic-induced unconsciousness. Front Syst Neurosci. 2014;8:115. + + + Perouansky M, Pearce RA, Hemmings HC Jr. Inhaled anesthetics: mechanism of action. In: Miller RD, ed. Miller’s Anesthesia. 8th ed. Saunders, 2014:614–626. + + + Kissin I. A concept for assessing interactions of general anesthetics. Anesth Analg. 1997;85:204–210. + + + +
+ + + 36917548 + + 2023 + 03 + 14 + +
+ + 1944-8252 + + + 2023 + Mar + 14 + + + ACS applied materials & interfaces + ACS Appl Mater Interfaces + + Dual-Mode Fiber Strain Sensor Based on Mechanochromic Photonic Crystal and Transparent Conductive Elastomer for Human Motion Detection. + 10.1021/acsami.3c00419 + + As an important component of wearable and stretchable strain sensors, dual-mode strain sensors can respond to deformation via optical/electrical dual-signal changes, which have important applications in human motion monitoring. However, realizing a fiber-shaped dual-mode strain sensor that can work stably in real life remains a challenge. Here, we design an interactive dual-mode fiber strain sensor with both mechanochromic and mechanoelectrical functions that can be applied to a variety of different environments. The dual-mode fiber is produced by coating a transparent elastic conductive layer onto photonic fiber composed of silica particles and elastic rubber. The sensor has visualized dynamic color change, a large strain range (0-80%), and a high sensitivity (1.90). Compared to other dual-mode strain sensors based on the photonic elastomer, our sensor exhibits a significant advantage in strain range. Most importantly, it can achieve reversible and stable optical/electrical dual-signal outputs in response to strain under various environmental conditions. As a wearable portable device, the dual-mode fiber strain sensor can be used for real-time monitoring of human motion, realizing the direct interaction between users and devices, and is expected to be used in fields such as smart wearable, human-machine interactions, and health monitoring. + + + + Zhao + Ruolan + R + + School of Optical and Electronic Information, Huazhong University of Science and Technology, Wuhan 430074, China. + + + + He + Yue + Y + + School of Optical and Electronic Information, Huazhong University of Science and Technology, Wuhan 430074, China. + + + + He + Yu + Y + + School of Optical and Electronic Information, Huazhong University of Science and Technology, Wuhan 430074, China. + + + + Li + Zhangcheng + Z + + School of Optical and Electronic Information, Huazhong University of Science and Technology, Wuhan 430074, China. + + + + Chen + Min + M + + Sport and Health Initiative, Optical Valley Laboratory and Wuhan National Laboratory for Optoelectronics, Wuhan 430074, China. + + + School of Computer Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China. + + + + Zhou + Ning + N + + Sport and Health Initiative, Optical Valley Laboratory and Wuhan National Laboratory for Optoelectronics, Wuhan 430074, China. + + + Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, China. + + + + Tao + Guangming + G + 0000-0002-1371-7735 + + Sport and Health Initiative, Optical Valley Laboratory and Wuhan National Laboratory for Optoelectronics, Wuhan 430074, China. + + + The State Key Laboratory of Material Processing and Die & Mould Technology, School of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China. + + + + Hou + Chong + C + 0000-0002-1975-0747 + + School of Optical and Electronic Information, Huazhong University of Science and Technology, Wuhan 430074, China. + + + Sport and Health Initiative, Optical Valley Laboratory and Wuhan National Laboratory for Optoelectronics, Wuhan 430074, China. + + + Research Institute of Huazhong University of Science and Technology in Shenzhen, Shenzhen 518063, China. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + ACS Appl Mater Interfaces + 101504991 + 1944-8244 + + IM + + fiber sensor + mechanochromism + photonic crystal + transparent conductive elastomer + wearable + +
+ + + + 2023 + 3 + 14 + 13 + 3 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917548 + 10.1021/acsami.3c00419 + + +
+ + + 36917554 + + 2023 + 03 + 14 + +
+ + 2042-3306 + + + 2023 + Mar + 14 + + + Equine veterinary journal + Equine Vet J + + Delayed embryonic development or a long sperm survival in two mares - a registration conundrum. + 10.1111/evj.13936 + + Genetic testing is required for registration of foals of most equine breeds. + To describe two clinical cases of marked delayed embryonic development or delayed fertilisation in pregnancies generated by embryo transfer. + Case report METHODS: Donor mares were inseminated with semen from one stallion during one oestrous cycle and semen from a different stallion on the subsequent oestrous cycle. Embryo(s) were collected 8 days after ovulation during the second oestrous cycle and transferred into synchronised recipient mares. Genetic testing was performed to determine parentage of the two foals. + For both foals, DNA parentage testing excluded the second stallion as the genetic sire and confirmed that the first stallion, whose semen was inseminated on the previous oestrous cycle, was the actual genetic sire. + Rare event in horses; two clinical cases are described. + It is hypothesised that either marked delayed embryonic development or extended sperm survival occurred in the donor mares. Without genetic testing, parentage assignment based solely on breeding records would have been incorrect. This article is protected by copyright. All rights reserved. + This article is protected by copyright. All rights reserved. + + + + McCue + Patrick M + PM + https://orcid.org/0000-0001-7597-3921 + + Colorado State University, Fort Collins, Colorado, 80521, USA. + + + + Matthews + Philip M + PM + + Peterson & Smith Equine Hospital, Ocala, Florida, 34474, USA. + + + + Prell + Melissa J + MJ + + Peterson & Smith Equine Hospital, Ocala, Florida, 34474, USA. + + + + Bellone + Rebecca R + RR + https://orcid.org/0000-0001-8838-7227 + + Veterinary Genetics Laboratory, School of Veterinary Medicine, University of California, Davis, California, 95616, USA. + + + Department of Population Health and Reproduction, School of Veterinary Medicine University of California, Davis, California, 95616, USA. + + + + Allen + Heather + H + + Bureau Veritas Laboratories, Guelph, Ontario, N1G 4P7, Canada. + + + + eng + + Case Reports + + + 2023 + 03 + 14 + +
+ + United States + Equine Vet J + 0173320 + 0425-1644 + + IM + + DNA + delayed + embryonic development + horse + parentage + +
+ + + + 2020 + 06 + 26 + + + 2023 + 03 + 08 + + + 2023 + 3 + 14 + 13 + 13 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917554 + 10.1111/evj.13936 + + +
+ + + 36917553 + + 2023 + 03 + 14 + +
+ + 1757-6199 + + + 2023 + Mar + 14 + + + Bioanalysis + Bioanalysis + + Perspective on high-throughput bioanalysis to support in vitro assays in early drug discovery. + 10.4155/bio-2022-0207 + + As the desire for a shortened design/make/test/learn cycle increases in early drug discovery, the pressure to rapidly deliver drug metabolism pharmacokinetic data continues to rise. From a bioanalytical standpoint, in vitro assays are challenging because they are amenable to automation and thus capable of generating a high number of samples for analysis. To keep up with analysis demands, automated method development workflows, rapid sample analysis approaches and efficient data analysis software must be utilized. This work provides an outline of how we implemented those three aspects to provide bioanalytical support for in vitro drug metabolism pharmacokinetic assays, which include developing hundreds of mass spectrometry methods and analyzing thousands of samples per week, while delivering a median bioanalytical turnaround time of 1-2 business days. + + + + Santiago + Brandon G + BG + 0000-0001-7112-878X + + Drug Metabolism & Pharmacokinetics, GSK, 1250 S. Collegeville Road, Collegeville, PA 19426, USA. + + + + Eisennagel + Stephen H + SH + 0009-0004-3053-2566 + + Drug Metabolism & Pharmacokinetics, GSK, 1250 S. Collegeville Road, Collegeville, PA 19426, USA. + + + + Peckham + Gregory E + GE + 0000-0003-3671-8973 + + Drug Metabolism & Pharmacokinetics, GSK, 1250 S. Collegeville Road, Collegeville, PA 19426, USA. + + + + Liebhardt + Amanda M + AM + 0009-0004-2271-8328 + + Drug Metabolism & Pharmacokinetics, GSK, 1250 S. Collegeville Road, Collegeville, PA 19426, USA. + + + + Alburn + Chad L + CL + + Drug Metabolism & Pharmacokinetics, GSK, 1250 S. Collegeville Road, Collegeville, PA 19426, USA. + + + + Roethke + Theresa J + TJ + + Drug Metabolism & Pharmacokinetics, GSK, 1250 S. Collegeville Road, Collegeville, PA 19426, USA. + + + + Reilly + Michael A + MA + + Drug Metabolism & Pharmacokinetics, GSK, 1250 S. Collegeville Road, Collegeville, PA 19426, USA. + + + + Sydor + Jens R + JR + + Drug Metabolism & Pharmacokinetics, GSK, 1250 S. Collegeville Road, Collegeville, PA 19426, USA. + + + + Karlinsey + Molly Z + MZ + 0009-0005-0529-396X + + Drug Metabolism & Pharmacokinetics, GSK, 1250 S. Collegeville Road, Collegeville, PA 19426, USA. + + + + eng + + Journal Article + Review + + + 2023 + 03 + 14 + +
+ + England + Bioanalysis + 101512484 + 1757-6180 + + IM + + DMPK + automation + bioanalysis + workflow optimization + +
+ + + + 2023 + 3 + 14 + 13 + 13 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917553 + 10.4155/bio-2022-0207 + + +
+ + + 36917552 + + 2023 + 03 + 14 + +
+ + 2054-1058 + + + 2023 + Mar + 14 + + + Nursing open + Nurs Open + + The lived experience of Chinese medical tourists receiving cancer care: A qualitative study. + 10.1002/nop2.1707 + + The purpose of this study was to describe and explore the lived experience of Chinese medical tourists receiving cancer care in clinical settings in the United States. + A qualitative phenomenological design. + In this study, Hermeneutic phenomenology was used to interview 11 participants on WeChat, a popular social media platform of China. Hermeneutic phenomenology methods and hermeneutic circles were used to analyse data. + Five themes identified were: the application process involves various challenges; overcoming transportation and language barriers; feeling content with healthcare received in the United States; nearly perfect experience, except for long waiting times; and high cost of being a medical tourist. + Despite the cost and complexity of cancer treatment, Chinese medical tourists valued their experience in US clinical settings. Although, they experienced real challenges, they overcame obstacles with self-determination and varied resources. Therefore, culturally appropriate healthcare is highly recommended. + The findings of this study are relevant for clinical practice, particularly cancer care to medical tourists in the United States. To better support the Chinese medical tourists with cancer, various strategies and techniques, as reported in this study, could be helpful. It is highly recommended to provide healthcare providers to enable them to understand and respect the diversity norms of other cultures. + © 2023 The Authors. Nursing Open published by John Wiley & Sons Ltd. + + + + Xu + Tuzhen + T + https://orcid.org/0000-0001-6552-5949 + + College of Nursing, Texas Woman's University, Houston, TX, USA. + + + + Liu + Fuqin + F + + College of Nursing, Texas Woman's University, Houston, TX, USA. + + + + Cesario + Sandra K + SK + + College of Nursing, Texas Woman's University, Houston, TX, USA. + + + + Moore + Brenda + B + + College of Nursing, Texas Woman's University, Houston, TX, USA. + + + + eng + + + 2021 John Winston Carter Small Research Grant + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Nurs Open + 101675107 + 2054-1058 + + IM + + cancer + lived experience + medical tourists + transcultural nursing + +
+ + + + 2023 + 02 + 16 + + + 2022 + 08 + 10 + + + 2023 + 02 + 20 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 14 + 13 + 12 + + + aheadofprint + + 36917552 + 10.1002/nop2.1707 + + + REFERENCES + + Al-Shamsi, H. O., Al-Hajeili, M., & Alrawi, S. (2018). Chasing the cure around the globe: Medical tourism for cancer care From developing countries. Journal of Global Oncology, 4, 1-3 https://doi.org/10.1200/jgo.17.00087 + + + Analytica, O. (2015). Major healthcare push lies ahead for China. Expert Briefings. https://doi.org/10.1108/OXAN-DB198578 + + + Armour, M., Rivaux, S. L., & Bell, H. (2009). Using context to build rigor: Application to two hermeneutic phenomenological studies. Qualitative Social Work, 8(1), 101-122. https://doi.org/10.1177/1473325008100424 + + + Bagga, T., Vishnoi, S., Jain, S., & Sharma, R. (2020). Medical tourism: Treatment, therapy & tourism. 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Medical tourism: Sea, sun, sand and … surgery. Tourism Management, 27(6), 1093-1100 https://doi.org/10.1016/j.tourman.2005.11.005 + + + Drinkert, A., & Singh, N. (2017). An investigation of American medical tourists' posttravel experience. Journal of Hospitality Marketing and Management, 26(3), 335-346. https://doi.org/10.1080/19368623.2017.1241199 + + + Dummett, S. M. (2002). The shorter logical investigations. Routledge. + + + Feng, R.-M., Zong, Y.-N., Cao, S.-M., & Xu, R.-H. (2019). Current cancer situation in China: Good or bad news from the 2018 Global Cancer Statistics? Cancer Communications, 39(1), 22. Portico https://doi.org/10.1186/s40880-019-0368-6 + + + Footman, K., Mitrio, S., Zanon, D., Glonti, K., Risso-Gill, I., McKee, M., & Knai, C. (2015). Dialysis services for tourists to the Veneto region: A qualitative study. Journal of Renal Care, 41(1), 19-27. https://doi.org/10.1111/jorc.12088 + + + Gentles, S. J., Charles, C., Ploeg, J., & Ann McKibbon, K. (2015). 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Medical tourism and telemedicine: A new frontier of an old business. Journal of Medical Internet Research, 18(5), e115 https://doi.org/10.2196/jmir.5432 + + + Hudson, N., Culley, L., Blyth, E., Norton, W., Pacey, A., & Rapport, F. (2016). Cross-border-assisted reproduction: a qualitative account of UK travellers’ experiences. Human Fertility, 19(2), 102-110 https://doi.org/10.3109/14647273.2016.1168530 + + + Institute of Medicine (US) Committee on Understanding and Eliminating Racial and Ethnic Disparities in Health Care. (2003). Unequal treatment: Confronting racial and ethnic disparities in health care (with CD). National Academies Press (US). + + + Izumi, S., Baggs, J. G., & Knafl, K. A. (2010). Quality nursing care for hospitalized patients with advanced illness: Concept development. Research in Nursing & Health, 33(4), 299-315. https://doi.org/10.1002/nur.20391 + + + Karuppan, C. M., & Karuppan, M. (2011). Who Are the Medical Travelers and What Do They Want?: A Qualitative Study. 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INQUIRY: The Journal of Health Care Organization, Provision, and Financing, 57, 004695802092676 https://doi.org/10.1177/0046958020926762 + + + Young, L. K., Vimawala, S., Ahmad, N., Kushnir, V., Bonawitz, S. C., Brody, J. D., Enriquez, M. L., & Koshkareva, Y. A. (2019). Review of inbound medical tourism and legal details of obtaining a visa for treatment of head and neck cancer. Head & Neck. Portico. https://doi.org/10.1002/hed.25743 + + + Yum, J. O. (1988). The impact of confucianism on interpersonal relationships and communication patterns in East Asia. Communication Monographs, 55, 374-388. + + + Zeng, H., Ran, X., An, L., Zheng, R., Zhang, S., Ji, J. S., Zhang, Y., Chen, W., Wei, W., & He, J. (2021). Disparities in stage at diagnosis for five common cancers in China: a multicentre, hospital-based, observational study. The Lancet Public Health, 6(12), e877-e887 https://doi.org/10.1016/s2468-2667(21)00157-2 + + + +
+ + + 36917561 + + 2023 + 03 + 14 + +
+ + 1520-5207 + + + 2023 + Mar + 14 + + + The journal of physical chemistry. B + J Phys Chem B + + Interpreting Transient Interactions of Intrinsically Disordered Proteins. + 10.1021/acs.jpcb.3c00096 + + The flexible nature of intrinsically disordered proteins (IDPs) gives rise to a conformational ensemble with a diverse set of conformations. The simplest way to describe this ensemble is through a homopolymer model without any specific interactions. However, there has been growing evidence that the conformational properties of IDPs and their relevant functions can be affected by transient interactions between specific and even nonlocal pairs of amino acids. Interpreting these interactions from experimental methods, each of which is most sensitive to a different distance regime referred to as probing length, remains a challenging and unsolved problem. Here, we first show that transient interactions can be realized between short fragments of charged amino acids by generating conformational ensembles using model disordered peptides and coarse-grained simulations. Using these ensembles, we investigate how sensitive different types of experimental measurements are to the presence of transient interactions. We find methods with shorter probing lengths to be more appropriate for detecting these transient interactions, but one experimental method is not sufficient due to the existence of other weak interactions typically seen in IDPs. Finally, we develop an adjusted polymer model with an additional short-distance peak which can robustly reproduce the distance distribution function from two experimental measurements with complementary short and long probing lengths. This new model can suggest whether a homopolymer model is insufficient for describing a specific IDP and meets the challenge of quantitatively identifying specific, transient interactions from a background of nonspecific, weak interactions. + + + + Wohl + Samuel + S + + Department of Physics, Arizona State University, Tempe, Arizona 85287, United States. + + + + Zheng + Wenwei + W + 0000-0002-9603-009X + + College of Integrative Sciences and Arts, Arizona State University, Mesa, Arizona 85212, United States. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + J Phys Chem B + 101157530 + 1520-5207 + + IM +
+ + + + 2023 + 3 + 14 + 13 + 23 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917561 + 10.1021/acs.jpcb.3c00096 + + +
+ + + 36917559 + + 2023 + 03 + 14 + +
+ + 2162-3279 + + + 2023 + Mar + 14 + + + Brain and behavior + Brain Behav + + Depressive symptoms, perceived social support, and anticipated HIV stigma among HIV-negative/unknown men who have sex with men in China during the COVID-19 pandemic: A multicenter online cross-sectional study. + + e2946 + + 10.1002/brb3.2946 + + To investigate the prevalence of depressive symptoms among human immunodeficiency virus (HIV)-negative/unknown men who have sex with men (MSM) in China and explore the relationship between perceived social support, anticipated HIV stigma, and depressive symptoms. + Participants in this study were recruited from a gay social networking app (Blued) in China by convenience sampling from December 16, 2020 to March 1, 2021. Perceived Social Support Questionnaire, Anticipated HIV Stigma Questionnaire, and Center for Epidemiologic Studies Depression Scale were used to measure the social support, anticipated HIV stigma, and depressive symptoms of participants. Confirmatory factor analysis was performed to assess the reliability and validity of the measurement model. Structural equation modeling was employed to evaluate the association of perceived social support, anticipated HIV stigma, and depressive symptoms, as well as the mediation effects. + Overall, 47.70% (665/1394) of the participants had depressive symptoms. Perceived social support could have both direct and indirect effects on depressive symptoms with the mediating role of anticipated HIV stigma among HIV-negative/unknown MSM. + Tailored interventions regarding perceived social support and anticipated HIV stigma, such as group therapy, mutual support groups and mindfulness training, with the involvement of non-governmental or governmental organizations, should be taken into account to reduce depressive symptoms and stigma among HIV-negative/unknown MSM in China. + © 2023 The Authors. Brain and Behavior published by Wiley Periodicals LLC. + + + + Dai + Zhenwei + Z + https://orcid.org/0000-0002-7508-008X + + School of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. + + + + Fu + Jiaqi + J + + School of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. + + + + Qu + Yimin + Y + + School of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. + + + + Wu + Yijin + Y + + School of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. + + + + Si + Mingyu + M + + School of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. + + + + Chen + Xu + X + + School of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. + + + + Wang + Hao + H + + School of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. + + + + Xiao + Weijun + W + + School of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. + + + + Huang + Yiman + Y + + School of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. + + + + Yu + Fei + F + + Danlan Public Welfare, Beijing, China. + + + + Mi + Guodong + G + + Danlan Public Welfare, Beijing, China. + + + + Su + Xiaoyou + X + + School of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. + + + + eng + + + 2020-I2M-2-015 + Innovative Engineering Program sponsored by Chinese Academy of Medical Sciences + + + + BLXM01 + Asian Regional Special Cooperation Fund of National Health Commission of the People's Republic of China + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Brain Behav + 101570837 + + IM + + depressive symptoms + mediation effect + men who have sex with men + social support + stigma + +
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B., Loder, E., Zeidan, F., & Houle, T. T. (2021). Effectiveness of mindfulness meditation vs headache education for adults with migraine: A randomized clinical trial. JAMA Internal Medicine, 181(3), 317-328. https://doi.org/10.1001/jamainternmed.2020.7090 + + + Wu, D., Huang, W., Zhao, P., Li, C., Cao, B., Wang, Y., Stoneking, S., Tang, W., Luo, Z., Wei, C., & Tucker, J. (2019). A crowdsourced physician finder prototype platform for men who have sex with men in China: Qualitative study of acceptability and feasibility. JMIR Public Health and Surveillance, 5(4), e13027. https://doi.org/10.2196/13027 + + + Xie, Y., & Peng, M. (2018). Attitudes toward homosexuality in China: Exploring the effects of religion, modernizing factors, and traditional culture. Journal of Homosexuality, 65(13), 1758-1787. https://doi.org/10.1080/00918369.2017.1386025 + + + Xu, J., Ou, J., Luo, S., Wang, Z., Chang, E., Novak, C., Shen, J., Zheng, S., & Wang, Y. (2020). Perceived social support protects lonely people against COVID-19 anxiety: A three-wave longitudinal study in China. Frontiers in Psychology, 11, 566965. https://doi.org/10.3389/fpsyg.2020.566965 + + + 25.Yan, H., Li, X., Li, J., Wang, W., Yang, Y., Yao, X., Yang, N., & Li, S. (2019). Association between perceived HIV stigma, social support, resilience, self-esteem, and depressive symptoms among HIV-positive men who have sex with men (MSM) in Nanjing, China. AIDS Care, 31(9), 1069-1076. https://doi.org/10.1080/09540121.2019.1601677 + + + Yoneda, K., Hababeh, M., Kitamura, A., Seita, A., & Kamiya, Y. (2021). Prevalence and characteristics of Palestine refugee mothers at risk of postpartum depression in Amman, Jordan: A cross-sectional study. Lancet, 398(1), S28. https://doi.org/10.1016/S0140-6736(21)01514-2 + + + Yu, S.-C., Lin, Y.-H., & Hsu, W.-H. (2013). Applying structural equation modeling to report psychometric properties of Chinese version 10-item CES-D depression scale. 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+ + + 36917563 + + 2023 + 03 + 14 + +
+ + 1932-6203 + + 18 + 3 + + 2023 + + + PloS one + PLoS One + + Lessons from zoom-university: Post-secondary student consequences and coping during the COVID-19 pandemic-A focus group study. + + e0281438 + + 10.1371/journal.pone.0281438 + + The COVID-19 pandemic dramatically altered the model of university education. However, the most salient challenges associated with online learning, how university students are coping with these challenges, and the impact these changes have had on students' communities of learning remain relatively unexplored. Changes to the learning environment have also disrupted existing communities of learning for both lower and upper-year students. Hence, the purpose of our study was to explore how: (1) academic and personal/interpersonal challenges as a result of COVID-19; (2) formal and informal strategies used to cope with these academic and non-academic challenges; (3) and services or resources provided by the institution, if any, affected students' communities of learning. Six focus groups of 5-6 students were conducted, with two focus groups specifically dedicated to upper and lower year students. Questions related to academic and interpersonal challenges, formal and informal coping strategies, and access to/use of university services/resources were posed. Common challenges included poor accommodation from professors and administrators; burnout from little separation school and personal life; lack of support for students transitioning out of university; and difficulties forming and maintaining social networks. These findings suggest the importance of fostering communities of learning informally and formally at universities beyond the pandemic context. + Copyright: © 2023 Morava et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Morava + Anisa + A + https://orcid.org/0000-0001-9350-9639 + + School of Kinesiology, Western University, London, ON, Canada. + + + + Sui + Anna + A + + Department of Health and Rehabilitation Sciences, Western University, London, ON, Canada. + + + + Ahn + Joshua + J + + School of Kinesiology, Western University, London, ON, Canada. + + + + Sui + Wuyou + W + + School of Kinesiology, Western University, London, ON, Canada. + + + + Prapavessis + Harry + H + + School of Kinesiology, Western University, London, ON, Canada. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 09 + 29 + + + 2023 + 01 + 23 + + + 2023 + 3 + 14 + 13 + 32 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917563 + 10.1371/journal.pone.0281438 + PONE-D-22-26821 + + +
+ + + 36917560 + + 2023 + 03 + 14 + +
+ + 2162-3279 + + + 2023 + Mar + 14 + + + Brain and behavior + Brain Behav + + Using functional near-infrared spectroscopy to measure prefrontal cortex activity during dual-task walking and navigated walking: A feasibility study. + + e2948 + + 10.1002/brb3.2948 + + While functional near-infrared spectroscopy (fNIRS) can provide insight into motor-cognitive deficits during ecologically valid gait conditions, the feasibility of using fNIRS during complex walking remains unknown. We tested the process and scientific feasibility of using an fNIRS device to measure cortical activity during complex walking tasks consisting of straight walking and navigated walking under single and dual-task (DT) conditions. + Nineteen healthy people from 18 to 64 years (mean age: 45.7 years) participated in this study which consisted of three complex walking protocols: (i) straight walking, DT walking (walking while performing an auditory Stroop task) and single-task auditory Stroop, (ii) straight and navigated walking, and (iii) navigated walking and navigated DT walking. A rest condition (standing still) was also included in each protocol. Process feasibility outcomes included evaluation of the test procedures and participant experience during and after each protocol. Scientific feasibility outcomes included signal quality measures, and the ability to measure changes in concentration of deoxygenated and oxygenated hemoglobin in the prefrontal cortex. + All participants were able to complete the three protocols with most agreeing that the equipment was comfortable (57.9%) and that the testing duration was adequate (73.7%). Most participants did not feel tired (94.7%) with some experiencing pain (42.1%) during the protocols. The signal qualities were high for each protocol. Compared to the rest condition, there was an increase in oxygenated hemoglobin in the prefrontal cortex when performing dual-task walking and navigation. + We showed that our experimental setup was feasible for assessing activity in the prefrontal cortex with fNIRS during complex walking. The experimental setup was deemed acceptable and practicable. Signal quality was good during complex walking conditions and findings suggest that the different tasks elicit a differential brain activity, supporting scientific feasibility. + © 2023 The Authors. Brain and Behavior published by Wiley Periodicals LLC. + + + + Kvist + Alexander + A + https://orcid.org/0000-0001-7431-2144 + + Department of Neurobiology, Care sciences and Society, Division of Physiotherapy, Karolinska Institutet, Stockholm, Sweden. + + + + Bezuidenhout + Lucian + L + + Department of Neurobiology, Care sciences and Society, Division of Physiotherapy, Karolinska Institutet, Stockholm, Sweden. + + + Faculty of Community and Health Sciences, University of Western Cape, Cape Town, South Africa. + + + + Johansson + Hanna + H + + Department of Neurobiology, Care sciences and Society, Division of Physiotherapy, Karolinska Institutet, Stockholm, Sweden. + + + Women's Health and Allied Health Professionals Theme, Medical Unit Occupational Therapy & Physiotherapy, Karolinska University Hospital, Stockholm, Sweden. + + + + Albrecht + Franziska + F + + Department of Neurobiology, Care sciences and Society, Division of Physiotherapy, Karolinska Institutet, Stockholm, Sweden. + + + Women's Health and Allied Health Professionals Theme, Medical Unit Occupational Therapy & Physiotherapy, Karolinska University Hospital, Stockholm, Sweden. + + + + Ekman + Urban + U + + Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden. + + + Women's Health and Allied Health Professionals Theme, Medical Unit Medical Psychology, Karolinska University Hospital, Stockholm, Sweden. + + + + Conradsson + David Moulaee + DM + + Department of Neurobiology, Care sciences and Society, Division of Physiotherapy, Karolinska Institutet, Stockholm, Sweden. + + + Women's Health and Allied Health Professionals Theme, Medical Unit Occupational Therapy & Physiotherapy, Karolinska University Hospital, Stockholm, Sweden. + + + + Franzén + Erika + E + + Department of Neurobiology, Care sciences and Society, Division of Physiotherapy, Karolinska Institutet, Stockholm, Sweden. + + + Women's Health and Allied Health Professionals Theme, Medical Unit Occupational Therapy & Physiotherapy, Karolinska University Hospital, Stockholm, Sweden. + + + + eng + + + Doctoral School in Health Science, Karolinska Institutet + + + + Swedish state under the agreement between the Swedish government and the county councils, the ALF-agreement + + + + Center for Innovative Medicine, Karolinska Institutet + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Brain Behav + 101570837 + + IM + + dual-task walking + fNIRS + navigation + walking + +
+ + + + 2023 + 02 + 15 + + + 2022 + 09 + 06 + + + 2023 + 02 + 17 + + + 2023 + 3 + 14 + 13 + 23 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917560 + 10.1002/brb3.2948 + + + REFERENCES + + Amaro, E., & Barker, G. J. (2006). Study design in fMRI: Basic principles. Brain and Cognition, 60(3), 220-232. + + + Amboni, M., Barone, P., & & Hausdorff, J. M. (2013). Cognitive contributions to gait and falls: Evidence and implications. Movement Disorders, 28(11), 1520-1533. + + + Barker, J. W., Aarabi, A., & Huppert, T. J. (2013). Autoregressive model based algorithm for correcting motion and serially correlated errors in fNIRS. Biomedical Optics Express, 4(8), 1366-1379. + + + Bishnoi, A., Holtzer, R., & Hernandez, M. E. (2021). Brain activation changes while walking in adults with and without neurological disease: Systematic review and meta-analysis of functional near-infrared spectroscopy studies. Brain Sciences, 11(3), 291. + + + Bürki, C. 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+ + + 36917565 + + 2023 + 03 + 14 + +
+ + 1932-6203 + + 18 + 3 + + 2023 + + + PloS one + PLoS One + + Molecular characterizations of genes in chloroplast genomes of the genus Arachis L. (Fabaceae) based on the codon usage divergence. + + e0281843 + + 10.1371/journal.pone.0281843 + + Studies on the molecular characteristics of chloroplast genome are generally important for clarifying the evolutionary processes of plant species. The base composition, the effective number of codons, the relative synonymous codon usage, the codon bias index, and their correlation coefficients of a total of 41 genes in 21 chloroplast genomes of the genus Arachis were investigated to further perform the correspondence and clustering analyses, revealing significantly higher variations in genomes of wild species than those of the cultivated taxa. The codon usage patterns of all 41 genes in the genus Arachis were AT-rich, suggesting that the natural selection was the main factor affecting the evolutionary history of these genomes. Five genes (i.e., ndhC, petD, atpF, rpl14, and rps11) and five genes (i.e., atpE, psbD, psaB, ycf2, and rps12) showed higher and lower base usage divergences, respectively. This study provided novel insights into our understanding of the molecular evolution of chloroplast genomes in the genus Arachis. + Copyright: © 2023 Yang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Yang + Shuwei + S + + School of Intelligent Science and Information Engineering, Xi'an Peihua University, Xi'An, Shaanxi, China. + + + + Li + Gun + G + https://orcid.org/0000-0002-8788-2899 + + Department of Biomedical Engineering, Laboratory for Biodiversity Science, School of Electronic Information Engineering, Xi'An Technological University, Xi'An, Shaanxi, China. + + + + Li + Hao + H + + College of Food Engineering, Jilin Engineering Normal University, Changchun, Jilin, China. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 08 + 18 + + + 2023 + 02 + 01 + + + 2023 + 3 + 14 + 13 + 32 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917565 + 10.1371/journal.pone.0281843 + PONE-D-22-23061 + + +
+ + + 36917562 + + 2023 + 03 + 14 + +
+ + 1557-8127 + + 21 + 2 + + 2023 Feb-Mar + + + Assay and drug development technologies + Assay Drug Dev Technol + + Pharmaceutical Methods for Enhancing the Dissolution of Poorly Water-Soluble Drugs. + + 65-79 + + 10.1089/adt.2022.119 + + + Low water solubility is the main hindrance in the growth of pharmaceutical industry. Approximately 90% of newer molecules under investigation for drugs and 40% of novel drugs have been reported to have low water solubility. The key and thought-provoking task for the formulation scientists is the development of novel techniques to overcome the solubility-related issues of these drugs. The main intention of present review is to depict the conventional and novel strategies to overcome the solubility-related problems of Biopharmaceutical Classification System Class-II drugs. More than 100 articles published in the last 5 years were reviewed to have a look at the strategies used for solubility enhancement. pH modification, salt forms, amorphous forms, surfactant solubilization, cosolvency, solid dispersions, inclusion complexation, polymeric micelles, crystals, size reduction, nanonization, proliposomes, liposomes, solid lipid nanoparticles, microemulsions, and self-emulsifying drug delivery systems are the various techniques to yield better bioavailability of poorly soluble drugs. The selection of solubility enhancement technique is based on the dosage form and physiochemical characteristics of drug molecules. + + + + + Mahmood + Tahir + T + 0000-0002-9169-8517 + + Department of Pharmaceutics, College of Pharmacy, University of Sargodha, Sargodha, Pakistan. + + + + Sarfraz + Rai M + RM + + Department of Pharmaceutics, College of Pharmacy, University of Sargodha, Sargodha, Pakistan. + + + + Ismail + Asmara + A + + Specialized Healthcare and Medical Education Department, Government of Punjab, Lahore, Pakistan. + + + + Ali + Muhammad + M + + Specialized Healthcare and Medical Education Department, Government of Punjab, Lahore, Pakistan. + + + + Khan + Abdur Rauf + AR + + Specialized Healthcare and Medical Education Department, Government of Punjab, Lahore, Pakistan. + + + + eng + + Journal Article + +
+ + United States + Assay Drug Dev Technol + 101151468 + 1540-658X + + IM + + bioavailability + cosolvency + drug delivery techniques + nanogels + solubility + +
+ + + + 2023 + 3 + 14 + 13 + 23 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + ppublish + + 36917562 + 10.1089/adt.2022.119 + + +
+ + + 36917572 + + 2023 + 03 + 14 + +
+ + 1932-6203 + + 18 + 3 + + 2023 + + + PloS one + PLoS One + + Can object identification difficulty be predicted based on disfluencies and eye-movements in connected speech? + + e0281589 + + 10.1371/journal.pone.0281589 + + In the current study, we asked whether delays in the earliest stages of picture naming elicit disfluency. To address this question, we used a network task, where participants describe the route taken by a marker through visually presented networks of objects. Additionally, given that disfluencies are arguably multifactorial, we combined this task with eye tracking, to be able to disentangle disfluency related to word preparation from other factors (e.g., stalling strategy). We used visual blurring, which hinders visual identification of the items and thereby slows down selection of a lexical concept. We tested the effect of this manipulation on disfluency production and visual attention. Blurriness did not lead to more disfluency on average and viewing times decreased with blurred pictures. However, multivariate pattern analyses revealed that a classifier could predict above chance, from the pattern of disfluency, whether each participant was about to name blurred or control pictures. Impeding the conceptual generation of a message therefore affected the pattern of disfluencies of each participant individually, but this pattern was not consistent from one participant to another. Additionally, some of the disfluency and eye-movement variables correlated with individual cognitive differences, in particular with inhibition. + Copyright: © 2023 Pistono, Hartsuiker. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Pistono + Aurélie + A + https://orcid.org/0000-0001-7363-5232 + + Department of Experimental Psychology, Ghent University, Ghent, Belgium. + + + + Hartsuiker + Robert J + RJ + + Department of Experimental Psychology, Ghent University, Ghent, Belgium. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 07 + 14 + + + 2023 + 01 + 26 + + + 2023 + 3 + 14 + 13 + 33 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917572 + 10.1371/journal.pone.0281589 + PONE-D-22-19855 + + +
+ + + 36917567 + + 2023 + 03 + 14 + +
+ + 1545-7885 + + 21 + 3 + + 2023 + Mar + + + PLoS biology + PLoS Biol + + Individuals with problem gambling and obsessive-compulsive disorder learn through distinct reinforcement mechanisms. + + e3002031 + + 10.1371/journal.pbio.3002031 + + Obsessive-compulsive disorder (OCD) and pathological gambling (PG) are accompanied by deficits in behavioural flexibility. In reinforcement learning, this inflexibility can reflect asymmetric learning from outcomes above and below expectations. In alternative frameworks, it reflects perseveration independent of learning. Here, we examine evidence for asymmetric reward-learning in OCD and PG by leveraging model-based functional magnetic resonance imaging (fMRI). Compared with healthy controls (HC), OCD patients exhibited a lower learning rate for worse-than-expected outcomes, which was associated with the attenuated encoding of negative reward prediction errors in the dorsomedial prefrontal cortex and the dorsal striatum. PG patients showed higher and lower learning rates for better- and worse-than-expected outcomes, respectively, accompanied by higher encoding of positive reward prediction errors in the anterior insula than HC. Perseveration did not differ considerably between the patient groups and HC. These findings elucidate the neural computations of reward-learning that are altered in OCD and PG, providing a potential account of behavioural inflexibility in those mental disorders. + Copyright: © 2023 Suzuki et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Suzuki + Shinsuke + S + https://orcid.org/0000-0002-9816-9423 + + Centre for Brain, Mind and Markets, The University of Melbourne, Carlton, Australia. + + + Center for the Promotion of Social Data Science Education and Research, Hitotsubashi University, Tokyo, Japan. + + + + Zhang + Xiaoliu + X + + BrainPark, Turner Institute for Brain and Mental Health, School of Psychological Sciences, and Monash Biomedical Imaging Facility, Monash University, Clayton, Australia. + + + + Dezfouli + Amir + A + + Data61, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Sydney, Australia. + + + + Braganza + Leah + L + + BrainPark, Turner Institute for Brain and Mental Health, School of Psychological Sciences, and Monash Biomedical Imaging Facility, Monash University, Clayton, Australia. + + + + Fulcher + Ben D + BD + + School of Physics, The University of Sydney, Sydney, Australia. + + + + Parkes + Linden + L + + BrainPark, Turner Institute for Brain and Mental Health, School of Psychological Sciences, and Monash Biomedical Imaging Facility, Monash University, Clayton, Australia. + + + Department of Bioengineering, School of Engineering & Applied Science, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America. + + + + Fontenelle + Leonardo F + LF + + BrainPark, Turner Institute for Brain and Mental Health, School of Psychological Sciences, and Monash Biomedical Imaging Facility, Monash University, Clayton, Australia. + + + + Harrison + Ben J + BJ + + Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Carlton, Australia. + + + + Murawski + Carsten + C + + Centre for Brain, Mind and Markets, The University of Melbourne, Carlton, Australia. + + + + Yücel + Murat + M + + BrainPark, Turner Institute for Brain and Mental Health, School of Psychological Sciences, and Monash Biomedical Imaging Facility, Monash University, Clayton, Australia. + + + + Suo + Chao + C + + BrainPark, Turner Institute for Brain and Mental Health, School of Psychological Sciences, and Monash Biomedical Imaging Facility, Monash University, Clayton, Australia. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + PLoS Biol + 101183755 + 1544-9173 + + IM + I have read the journal’s policy and the authors of this manuscript have the following competing interests: M.Y. receives funding from National Health and Medical Research Council of Australia schemes, Monash University, and Australian Government funding bodies such as the Australian Research Council, Australian Defence Science and Technology, and the Department of Industry, Innovation and Science. He has also received philanthropic donations from the David Winston Turner Endowment Fund, Wilson Foundation, as well as payments in relation to court-, expert witness-, and/or expert review-reports. Finally, he has received funding to conduct sponsored Investigator-Initiated trials (including Incannex Healthcare Ltd). He also sits on the Advisory Boards of Centre of The Urban Mental Health, University of Amsterdam; Enosis Therapeutics; and Monash Biomedical Imaging Centre. L.P. was supported by the National Institute Of Mental Health of the National Institutes of Health (K99MH127296) and a 2020 NARSAD Young Investigator Grant from the Brain & Behavior Research Foundation. The other authors declare no competing interests. +
+ + + + 2022 + 07 + 11 + + + 2023 + 02 + 08 + + + 2023 + 3 + 14 + 13 + 32 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917567 + 10.1371/journal.pbio.3002031 + PBIOLOGY-D-22-01499 + + +
+ + + 36917577 + + 2023 + 03 + 14 + +
+ + 1932-6203 + + 18 + 3 + + 2023 + + + PloS one + PLoS One + + Prevalence and associated factors of insomnia symptoms during the COVID-19 pandemic lockdown among Mettu town residents. + + e0279624 + + 10.1371/journal.pone.0279624 + + Insomnia is a prevalent sleep disorder that affects people all over the world. Creating suitable interventions will require a better understanding of the magnitude and determinants of insomnia. This study aimed to assess the prevalence and associated factors of insomnia symptoms among residents of Mettu town during the pandemic lockdown. + A community-based cross-sectional study was conducted among residents of Mettu town from October 1st to October 15th, 2020. Residents who lived in Mettu town at least for six months were included. To determine the prevalence and determinants of insomnia symptoms, both descriptive and inferential analyses were used. The chi-squared test of association and logistic regression was used to identify predictors of insomnia symptoms among residents of Mettu town. We used SPSS version 25 for all statistical analyses. + The prevalence of depressive symptoms among residents of Mettu town was 52.6%. According to results of multivariable binary logistic regression, being female [AOR = 3.677, 95%CI: 2.124-6.365], being aged between 19 and 40 [AOR = 13.261, 95%CI: 6.953-25.291], being aged above 41 [AOR = 2.627, 95%CI: 1.120-6.159], smoking [AOR = 15.539, 95%CI: 7.961-30.329], satisfaction with information available [AOR = 0.310, 95%CI: 0.168-0.570], fear Corona Virus Disease 2019 (COVID-19), [AOR = 2.171, 95%CI: 1.262-3.733], feeling alienated from others [AOR = 3.288, 95%CI: 1.897-5.699], having somatic symptoms [AOR = 2.298, 95% CI: 1.360-3.884], having depressive symptoms [AOR = 1.841, 95% CI: 1.073-3.160], and experiencing psychological distress [AOR = 1.962, 95% CI: 1.173-3.281] were significantly associated with insomnia symptoms. + In this study, the prevalence of insomnia symptoms was found to be high among residents of Mettu town. Being female, being aged between 19 and 40, being aged above 41 years, smoking, fear of Corona Virus Disease 2019, feeling alienated from others, having somatic symptoms, having depressive symptoms, and experiencing psychological distress were all associated with an increased risk of developing insomnia symptoms while being satisfied with the information available decreased the risk of insomnia symptoms among residents of Mettu town. Interventions should be put in place to promote healthy sleep among residents of Mettu town. + Copyright: © 2023 Lelisho et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Lelisho + Mesfin Esayas + ME + https://orcid.org/0000-0002-3207-1829 + + Department of Statistics, College of Natural & Computational Science, Mizan-Tepi University, Tepi, Ethiopia. + + + + Wotale + Teramaj Wongel + TW + + Department of Statistics, College of Natural Science, Mettu University, Mettu, Oromia, Ethiopia. + + + + Tareke + Seid Ali + SA + https://orcid.org/0000-0002-7653-6026 + + Department of Statistics, College of Natural & Computational Science, Mizan-Tepi University, Tepi, Ethiopia. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2021 + 12 + 03 + + + 2022 + 11 + 28 + + + 2023 + 3 + 14 + 13 + 33 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917577 + 10.1371/journal.pone.0279624 + PONE-D-21-38278 + + +
+ + + 36917576 + + 2023 + 03 + 14 + +
+ + 1932-6203 + + 18 + 3 + + 2023 + + + PloS one + PLoS One + + Data quality in online human-subjects research: Comparisons between MTurk, Prolific, CloudResearch, Qualtrics, and SONA. + + e0279720 + + 10.1371/journal.pone.0279720 + + With the proliferation of online data collection in human-subjects research, concerns have been raised over the presence of inattentive survey participants and non-human respondents (bots). We compared the quality of the data collected through five commonly used platforms. Data quality was indicated by the percentage of participants who meaningfully respond to the researcher's question (high quality) versus those who only contribute noise (low quality). We found that compared to MTurk, Qualtrics, or an undergraduate student sample (i.e., SONA), participants on Prolific and CloudResearch were more likely to pass various attention checks, provide meaningful answers, follow instructions, remember previously presented information, have a unique IP address and geolocation, and work slowly enough to be able to read all the items. We divided the samples into high- and low-quality respondents and computed the cost we paid per high-quality respondent. Prolific ($1.90) and CloudResearch ($2.00) were cheaper than MTurk ($4.36) and Qualtrics ($8.17). SONA cost $0.00, yet took the longest to collect the data. + Copyright: © 2023 Douglas et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Douglas + Benjamin D + BD + + Department of Psychology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America. + + + + Ewell + Patrick J + PJ + + Department of Psychology, Kenyon College, Gambier, Ohio, United States of America. + + + + Brauer + Markus + M + https://orcid.org/0000-0003-4395-2282 + + Department of Psychology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 04 + 11 + + + 2022 + 12 + 13 + + + 2023 + 3 + 14 + 13 + 33 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917576 + 10.1371/journal.pone.0279720 + PONE-D-22-10708 + + +
+ + + 36917575 + + 2023 + 03 + 14 + +
+ + 1520-5215 + + + 2023 + Mar + 14 + + + The journal of physical chemistry. A + J Phys Chem A + + Deciphering the Impact of Helium Tagging on Flexible Molecules: Probing Microsolvation Effects of Protonated Acetylene by Quantum Configurational Entropy. + 10.1021/acs.jpca.2c08967 + + Helium, the lightest and most weakly interacting noble gas, is well-known for its unsurpassed chemical inertness. In many applications of helium in experimental techniques, such as tagging, messenger, or nanodroplet isolation action spectroscopy of molecules or complexes, it is assumed that the interaction of helium with the respective species, and thus the resulting interaction-induced perturbation, is small enough not to affect their structure and dynamics. Here, we probe the impact of one up to many attached helium atoms on protonated acetylene─an important nonclassical carbocation subject to three-center two-electron bonding in its ground state structure─using highly accurate interaction potentials in conjunction with entropy-based higher-order nonlinear correlation analysis. In particular, using neural network potentials at CCSD(T) accuracy, we disclose the specific structural perturbations due to the tagging of C2H3+ with up to 20 He atoms at a temperature of 1 K. Analysis reveals that microsolvation by helium influences the structure of C2H3+ noticeably, while our investigation of the quantum configurational information entropy additionally shows that correlations between individual orientational degrees of freedom are affected as a function of cluster size. In particular, it is found that the most probable bridge-like structure of the ro-vibrational quantum ground state of C2H3+, which is nonplanar and trans-bent in contrast to the perfectly planar equilibrium structure, becomes increasingly more localized upon adding helium atoms. The remarkably nonlinear behavior of the angular correlations as a function of cluster size is traced back to the buildup of the quantum microsolvation shell that enhances anisotropy up to NHe = 6 while more and more isotropic solvation takes over beyond six. Our approach is general and thus sets the stage to investigate the salient effects on the structure of flexible molecules due to tagging beyond the specific case. + + + + Beckmann + Richard + R + 0000-0002-4575-7299 + + Lehrstuhl für Theoretische Chemie, Ruhr-Universität Bochum, 44780 Bochum, Germany. + + + + Topolnicki + Rafal + R + 0000-0003-4445-4736 + + Dioscuri Center in Topological Data Analysis, Institute of Mathematics, Polish Academy of Sciences, Śniadeckich 8, Warsaw 00-656, Poland. + + + Institute of Experimental Physics, University of Wrocław, 50-204 Wrocław, Poland. + + + + Marx + Dominik + D + + Lehrstuhl für Theoretische Chemie, Ruhr-Universität Bochum, 44780 Bochum, Germany. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + J Phys Chem A + 9890903 + 1089-5639 + + IM +
+ + + + 2023 + 3 + 14 + 13 + 33 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917575 + 10.1021/acs.jpca.2c08967 + + +
+ + + 36917571 + + 2023 + 03 + 14 + +
+ + 1932-6203 + + 18 + 3 + + 2023 + + + PloS one + PLoS One + + Clonal isolates of Treponema pallidum subsp. pallidum Nichols provide evidence for the occurrence of microevolution during experimental rabbit infection and in vitro culture. + + e0281187 + + 10.1371/journal.pone.0281187 + + The recent development of a system for long-term in vitro culture of the syphilis spirochete, Treponema pallidum subsp. pallidum, has introduced the possibility of detailed genetic analysis of this bacterium. In this study, the in vitro culture system was used to isolate and characterize clonal populations of T. pallidum subsp. pallidum Nichols, the most widely studied strain. In limiting dilutions experiments, it was possible to establish cultures with inocula as low as 0.5 T. pallidum per well despite the long generation time (~35 to 40 hours) of this organism. Six Nichols strain clones isolated by limiting dilution were characterized in detail. All clones exhibited indistinguishable morphology and motility, highly similar in vitro multiplication rates, and comparable infectivity in the rabbit model (ID50 ≤ 100 bacteria). Genomic sequencing revealed sequence heterogeneity in the form of insertions or deletions at 5 sites, single nucleotide variations at 20 sites, and polynucleotide (polyG/C) tract length differences at 22 locations. Genomic sequences of the uncloned Nichols strain preparations propagated in rabbits or in vitro cultures exhibited substantial heterogeneity at these locations, indicating coexistence of many varied 'clonotypes' within these populations. Nearly all genetic variations were specific for the Nichols strain and were not detected in the >280 T. pallidum genomic sequences that are currently available. We hypothesize that these Nichols strain-specific sequence variations arose independently either during human infection or within the 110 years since the strain's initial isolation, and thus represent examples of microevolution and divergence. + Copyright: © 2023 Edmondson et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Edmondson + Diane G + DG + https://orcid.org/0000-0003-3702-9715 + + Department of Pathology & Laboratory Medicine, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, United States of America. + + + + De Lay + Bridget D + BD + https://orcid.org/0000-0003-1354-1407 + + Department of Pathology & Laboratory Medicine, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, United States of America. + + + + Hanson + Blake M + BM + + Department of Pediatrics, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, United States of America. + + + Department of Epidemiology, Human Genetics & Environmental Sciences, Center for Infectious Diseases, School of Public Health, University of Texas Health Science Center, Houston, Texas, United States of America. + + + + Kowis + Lindsay E + LE + + Houston Methodist Research Institute, Infectious Disease, Houston, Texas, United States of America. + + + + Norris + Steven J + SJ + + Department of Pathology & Laboratory Medicine, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, United States of America. + + + Department of Microbiology & Molecular Genetics, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, United States of America. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 10 + 03 + + + 2023 + 01 + 17 + + + 2023 + 3 + 14 + 13 + 33 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917571 + 10.1371/journal.pone.0281187 + PONE-D-22-27272 + + +
+ + + 36917564 + + 2023 + 03 + 14 + +
+ + 1549-1676 + + 20 + 3 + + 2023 + Mar + + + PLoS medicine + PLoS Med + + Maternal immunisation against Group B Streptococcus: A global analysis of health impact and cost-effectiveness. + + e1004068 + + 10.1371/journal.pmed.1004068 + + Group B Streptococcus (GBS) can cause invasive disease (iGBS) in young infants, typically presenting as sepsis or meningitis, and is also associated with stillbirth and preterm birth. GBS vaccines are under development, but their potential health impact and cost-effectiveness have not been assessed globally. + We assessed the health impact and value (using net monetary benefit (NMB), which measures both health and economic effects of vaccination into monetary units) of GBS maternal vaccination in an annual cohort of 140 million pregnant women across 183 countries in 2020. Our analysis uses a decision tree model, incorporating risks of GBS-related health outcomes from an existing Bayesian disease burden model. We extrapolated country-specific GBS-related healthcare costs using data from a previous systematic review and calculated quality-adjusted life years (QALYs) lost due to infant mortality and long-term disability. We assumed 80% vaccine efficacy against iGBS and stillbirth, following the WHO Preferred Product Characteristics, and coverage based on the proportion of pregnant women receiving at least 4 antenatal visits. One dose was assumed to cost $50 in high-income countries, $15 in upper-middle income countries, and $3.50 in low-/lower-middle-income countries. We estimated NMB using alternative normative assumptions that may be adopted by policymakers. Vaccinating pregnant women could avert 127,000 (95% uncertainty range 63,300 to 248,000) early-onset and 87,300 (38,100 to 209,000) late-onset infant iGBS cases, 31,100 deaths (14,400 to 66,400), 17,900 (6,380 to 49,900) cases of moderate and severe neurodevelopmental impairment, and 23,000 (10,000 to 56,400) stillbirths. A vaccine effective against GBS-associated prematurity might also avert 185,000 (13,500 to 407,000) preterm births. Globally, a 1-dose vaccine programme could cost $1.7 billion but save $385 million in healthcare costs. Estimated global NMB ranged from $1.1 billion ($-0.2 to 3.8 billion) under the least favourable normative assumptions to $17 billion ($9.1 to 31 billion) under the most favourable normative assumptions. The main limitation of our analysis was the scarcity of data to inform some of the model parameters such as those governing health-related quality of life and long-term costs from disability, and how these parameters may vary across country contexts. + In this study, we found that maternal GBS vaccination could have a large impact on infant morbidity and mortality. Globally, a GBS maternal vaccine at reasonable prices is likely to be a cost-effective intervention. + Copyright: © 2023 Procter et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Procter + Simon R + SR + https://orcid.org/0000-0002-0380-1503 + + Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom. + + + Maternal, Adolescent, Reproductive & Child Health (MARCH) Centre, London School of Hygiene & Tropical Medicine, London, United Kingdom. + + + + Gonçalves + Bronner P + BP + https://orcid.org/0000-0002-3329-6050 + + Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom. + + + Maternal, Adolescent, Reproductive & Child Health (MARCH) Centre, London School of Hygiene & Tropical Medicine, London, United Kingdom. + + + + Paul + Proma + P + https://orcid.org/0000-0003-0258-1040 + + Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom. + + + Maternal, Adolescent, Reproductive & Child Health (MARCH) Centre, London School of Hygiene & Tropical Medicine, London, United Kingdom. + + + + Chandna + Jaya + J + https://orcid.org/0000-0001-9836-0554 + + Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom. + + + Maternal, Adolescent, Reproductive & Child Health (MARCH) Centre, London School of Hygiene & Tropical Medicine, London, United Kingdom. + + + + Seedat + Farah + F + + Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom. + + + Maternal, Adolescent, Reproductive & Child Health (MARCH) Centre, London School of Hygiene & Tropical Medicine, London, United Kingdom. + + + + Koukounari + Artemis + A + + Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom. + + + Maternal, Adolescent, Reproductive & Child Health (MARCH) Centre, London School of Hygiene & Tropical Medicine, London, United Kingdom. + + + + Hutubessy + Raymond + R + https://orcid.org/0000-0002-9286-5065 + + Department of Immunization, Vaccines and Biologicals (IVB), World Health Organization, Geneva, Switzerland. + + + + Trotter + Caroline + C + + Disease Dynamics Unit, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom. + + + + Lawn + Joy E + JE + https://orcid.org/0000-0002-4573-1443 + + Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom. + + + Maternal, Adolescent, Reproductive & Child Health (MARCH) Centre, London School of Hygiene & Tropical Medicine, London, United Kingdom. + + + + Jit + Mark + M + https://orcid.org/0000-0001-6658-8255 + + Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom. + + + School of Public Health, University of Hong Kong, Hong Kong SAR, China. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + PLoS Med + 101231360 + 1549-1277 + + IM + I have read the journal’s policy and the authors of this manuscript have the following competing interests: FS is employed by the UK NSC which developed the policy recommendation for maternal GBS screening. RH is member of the World Health Organisation. +
+ + + + 2022 + 07 + 07 + + + 2023 + 02 + 07 + + + 2023 + 3 + 14 + 13 + 32 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917564 + 10.1371/journal.pmed.1004068 + PMEDICINE-D-22-02313 + + +
+ + + 36917569 + + 2023 + 03 + 14 + +
+ + 1545-7885 + + 21 + 3 + + 2023 + Mar + + + PLoS biology + PLoS Biol + + Dancing to a different tune, can we switch from chemical to biological nitrogen fixation for sustainable food security? + + e3001982 + + 10.1371/journal.pbio.3001982 + + Our current food production systems are unsustainable, driven in part through the application of chemically fixed nitrogen. We need alternatives to empower farmers to maximise their productivity sustainably. Therefore, we explore the potential for transferring the root nodule symbiosis from legumes to other crops. Studies over the last decades have shown that preexisting developmental and signal transduction processes were recruited during the evolution of legume nodulation. This allows us to utilise these preexisting processes to engineer nitrogen fixation in target crops. Here, we highlight our understanding of legume nodulation and future research directions that might help to overcome the barrier of achieving self-fertilising crops. + Copyright: © 2023 Jhu, Oldroyd. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Jhu + Min-Yao + MY + + Crop Science Centre, Department of Plant Sciences, University of Cambridge, Cambridge, United Kingdom. + + + + Oldroyd + Giles E D + GED + https://orcid.org/0000-0002-5245-6355 + + Crop Science Centre, Department of Plant Sciences, University of Cambridge, Cambridge, United Kingdom. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + PLoS Biol + 101183755 + 1544-9173 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2023 + 3 + 14 + 13 + 33 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917569 + 10.1371/journal.pbio.3001982 + PBIOLOGY-D-22-02491 + + +
+ + + 36917566 + + 2023 + 03 + 14 + +
+ + 1932-6203 + + 18 + 3 + + 2023 + + + PloS one + PLoS One + + Defibrillation effectiveness and safety of the shock waveform used in a contemporary wearable cardioverter defibrillator: Results from animal and human studies. + + e0281340 + + 10.1371/journal.pone.0281340 + + The wearable cardioverter defibrillator (WCD) is used to protect patients at risk for sudden cardiac arrest. We examined defibrillation efficacy and safety of a biphasic truncated exponential waveform designed for use in a contemporary WCD in three animal studies and a human study. + Animal (swine) studies: #1: Efficacy comparison of a 170J BTE waveform (SHOCK A) to a 150J BTE waveform (SHOCK B) that approximates another commercially available waveform. Primary endpoint first shock success rate. #2: Efficacy comparison of the two waveforms at attenuated charge voltages in swine at three prespecified impedances. Primary endpoint first shock success rate. #3: Safety comparison of SHOCK A and SHOCK B in swine. Primary endpoint cardiac biomarker level changes baseline to 6 and 24 hours post-shock. Human Study: Efficacy comparison of SHOCK A to prespecified goal and safety evaluation. Primary endpoint cumulative first and second shock success rate. Safety endpoint adverse events. + Animal Studies #1: 120 VF episodes in six swine. First shock success rates for SHOCK A and SHOCK B were 100%; SHOCK A non-inferior to SHOCK B (entire 95% CI of rate difference above -10% margin, p < .001). #2: 2,160 VF episodes in thirty-six swine. Attenuated SHOCK A was non-inferior to attenuated SHOCK B at each impedance (entire 95% CI of rate difference above -10% margin, p < .001). #3: Ten swine, five shocked five times each with SHOCK A, five shocked five times each with SHOCK B. No significant difference in troponin I (p = 0.658) or creatine phosphokinase (p = 0.855) changes from baseline between SHOCK A and SHOCK B. Human Study: Thirteen patients, 100% VF conversion rate. Mild skin irritation from adhesive defibrillation pads in three patients. + The BTE waveform effectively and safely terminated induced VF in swine and a small sample in humans. + Human study clinical trial registration: URL: https://clinicaltrials.gov; Unique identifier: NCT04132466. + Copyright: © 2023 Gleva et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Gleva + Marye J + MJ + https://orcid.org/0000-0002-0755-6437 + + Division of Cardiology, Department of Medicine, Washington University in Saint Louis School of Medicine in Saint Louis, St. Louis, Missouri, United States of America. + + + + Sullivan + Joseph + J + + Kestra Medical Technologies, Inc., Redmond, Washington, United States of America. + + + + Crawford + Thomas C + TC + + Division of Cardiology, Department of Medicine, University of Michigan, Ann Arbor, Michigan, United States of America. + + + + Walcott + Greg + G + + Division of Cardiovascular Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America. + + + + Birgersdotter-Green + Ulrika + U + + University of California San Diego, San Diego, CA, United States of America. + + + + Branch + Kelley R + KR + + Division of Cardiology, Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America. + + + + Doshi + Rahul N + RN + + Honor Health, Scottsdale, AZ, United States of America. + + + + Kivilaid + Kaisa + K + + Labcorp Inc., Minneapolis, MN, United States of America. + + + + Brennan + Kelly + K + https://orcid.org/0000-0002-7698-7353 + + Kestra Medical Technologies, Inc., Redmond, Washington, United States of America. + + + + Rowbotham + Ron K + RK + + Kestra Medical Technologies, Inc., Redmond, Washington, United States of America. + + + + Gustavson + Laura M + LM + https://orcid.org/0000-0002-8212-3762 + + Kestra Medical Technologies, Inc., Redmond, Washington, United States of America. + + + + Poole + Jeanne E + JE + + Division of Cardiology, Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America. + + + + eng + + + ClinicalTrials.gov + + NCT04132466 + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + I have read the journal’s policy and the authors of this manuscript have the following competing interests: One US patent application related to the research presented in this manuscript - Defibrillation Waveforms for a Wearable Cardiac Defibrillator (Pub. No. US 2021/0196965 A1; Pub. Date: Jul 1, 2021) Taylor TG and Medema DK; “ASSURE WCD System” is a product of Kestra Medical Technologies, Inc. There are no other patents, products in development or marketed products to declare. Joseph Sullivan, Kelly Brennan, Ron K. Rowbotham and Laura M. Gustavson are employees and stockholders of Kestra Medical Technologies, Inc.; Marye J. Gleva reports modest speaking honoraria from ZOLL Medical and Gaffney Events Educational Trust, modest consulting honoraria from Kestra Medical Technologies, Inc., compensation from the University of Rochester (Rochester NY) and Prairie Education and Research Institute (Springfield, IL) for research committee participation; Greg Walcott reports institutional research support from Kestra Medical Technologies, Inc.; Kelley R. Branch reports institutional research grant support from Kestra Medical Technologies, Inc.; Jeanne E. Poole reports institutional research grant support from Kestra Medical Technologies, Inc., Biotronik and Atricure, compensation from the University of Rochester (Rochester NY) for research committee participation and from the Heart Rhythm Society for Core Concepts Educational Course and for Editor-in-Chief for the Heart Rhythm O2Journal. Jeanne Poole also reports honoraria from Medtronic for service on the Executive Committee for the WRAP_IT study and from Boston Scientific for participation on the Medical Advisory Board. The remaining authors declare no conflict of interest. This support does not alter our adherence to PLOS ONE policies on sharing data and materials. +
+ + + + 2021 + 12 + 13 + + + 2023 + 01 + 17 + + + 2023 + 3 + 14 + 13 + 32 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917566 + 10.1371/journal.pone.0281340 + PONE-D-21-38498 + + +
+ + + 36917574 + + 2023 + 03 + 14 + +
+ + 1545-7885 + + 21 + 3 + + 2023 + Mar + + + PLoS biology + PLoS Biol + + Structures of apo Cas12a and its complex with crRNA and DNA reveal the dynamics of ternary complex formation and target DNA cleavage. + + e3002023 + + 10.1371/journal.pbio.3002023 + + Cas12a is a programmable nuclease for adaptive immunity against invading nucleic acids in CRISPR-Cas systems. Here, we report the crystal structures of apo Cas12a from Lachnospiraceae bacterium MA2020 (Lb2) and the Lb2Cas12a+crRNA complex, as well as the cryo-EM structure and functional studies of the Lb2Cas12a+crRNA+DNA complex. We demonstrate that apo Lb2Cas12a assumes a unique, elongated conformation, whereas the Lb2Cas12a+crRNA binary complex exhibits a compact conformation that subsequently rearranges to a semi-open conformation in the Lb2Cas12a+crRNA+DNA ternary complex. Notably, in solution, apo Lb2Cas12a is dynamic and can exist in both elongated and compact forms. Residues from Met493 to Leu523 of the WED domain undergo major conformational changes to facilitate the required structural rearrangements. The REC lobe of Lb2Cas12a rotates 103° concomitant with rearrangement of the hinge region close to the WED and RuvC II domains to position the RNA-DNA duplex near the catalytic site. Our findings provide insight into crRNA recognition and the mechanism of target DNA cleavage. + Copyright: © 2023 Jianwei et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Jianwei + Li + L + + Department of Biological Sciences, National University of Singapore, Singapore, Singapore. + + + + Jobichen + Chacko + C + + Department of Biological Sciences, National University of Singapore, Singapore, Singapore. + + + + Machida + Satoru + S + + Department of Biological Sciences, National University of Singapore, Singapore, Singapore. + + + + Meng + Sun + S + + Department of Biological Sciences, National University of Singapore, Singapore, Singapore. + + + + Read + Randy J + RJ + + Department of Haematology, University of Cambridge, Cambridge, United Kingdom. + + + + Hongying + Chen + C + + Department of Biological Sciences, National University of Singapore, Singapore, Singapore. + + + + Jian + Shi + S + + Department of Biological Sciences, National University of Singapore, Singapore, Singapore. + + + + Yuan + Yuren Adam + YA + + Department of Biological Sciences, National University of Singapore, Singapore, Singapore. + + + + Sivaraman + J + J + https://orcid.org/0000-0001-9781-5326 + + Department of Biological Sciences, National University of Singapore, Singapore, Singapore. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + PLoS Biol + 101183755 + 1544-9173 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 05 + 05 + + + 2023 + 02 + 06 + + + 2023 + 3 + 14 + 13 + 33 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917574 + 10.1371/journal.pbio.3002023 + PBIOLOGY-D-22-01032 + + +
+ + + 36917578 + + 2023 + 03 + 14 + +
+ + 1932-6203 + + 18 + 3 + + 2023 + + + PloS one + PLoS One + + Sex-specific effects of a parasite on stress-induced freezing behavior in a natural beetle-nematode system. + + e0281149 + + 10.1371/journal.pone.0281149 + + Some animals react to predation threats or other stressors by adopting a freezing posture in an attempt to avoid detection, and the duration of this behavior usually corresponds with individual personality, such that timid individuals freeze longer. Despite decades of research on this or related behaviors (thanatosis), never has the impact of parasitism been considered. Parasites could prolong the duration, if hosts are less motivated to move (i.e. lethargic), or they could reduce it, if hosts are motivated to forage more to compensate for energy drain. We examined this behavior within a natural beetle-nematode system, where hosts (horned passalus beetles, Odontotaenius disjunctus) are parasitized by a nematode, Chondronema passali. We exposed beetles (n = 238) to four stressors in our lab, including noise, vibration, light and inversion, and recorded how long they adopt a frozen stance. Afterward, we determined nematode burdens, which can range from dozens to hundreds of worms. Beetles tended to freeze for 20 seconds on average, with some variation between stressors. We detected no effect of beetle mass on the duration of freezing, and this behavior did not differ in beetles collected during the breeding or non-breeding season. There was a surprising sex-based difference in the impact of nematodes; unparasitized females remained frozen twice as long as unparasitized males, but for beetles with heavy nematode burdens, the opposite was true. From this we infer that heavily parasitized females are more bold, while males with heavy burdens would be more timid. The explanation for this finding remains elusive, though we can rule out many possibilities based on prior work on this host-parasite system. + Copyright: © 2023 Davis et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Davis + Andrew K + AK + https://orcid.org/0000-0002-1945-1819 + + Odum School of Ecology, University of Georgia, Athens, GA, United States of America. + + + + Ladd + Richard R E + RRE + + Biological Sciences, University of Georgia, Athens, GA, United States of America. + + + + Smith + Farran + F + + Odum School of Ecology, University of Georgia, Athens, GA, United States of America. + + + + Shattuck + Anna + A + + Tulane University, New Orleans, LA, United States of America. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 05 + 03 + + + 2023 + 01 + 13 + + + 2023 + 3 + 14 + 13 + 33 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917578 + 10.1371/journal.pone.0281149 + PONE-D-22-12627 + + +
+ + + 36917568 + + 2023 + 03 + 14 + +
+ + 1932-6203 + + 18 + 3 + + 2023 + + + PloS one + PLoS One + + Attrition from HIV treatment after enrollment in a differentiated service delivery model: A cohort analysis of routine care in Zambia. + + e0280748 + + 10.1371/journal.pone.0280748 + + Many sub-Saharan Africa countries are scaling up differentiated service delivery (DSD) models for HIV treatment to increase access and remove barriers to care. We assessed factors associated with attrition after DSD model enrollment in Zambia, focusing on patient-level characteristics. + We conducted a retrospective record review using electronic medical records (EMR) of adults (≥15 years) initiated on antiretroviral (ART) between 01 January 2018 and 30 November 2021. Attrition was defined as lost to follow-up (LTFU) or died by November 30, 2021. We categorized DSD models into eight groups: fast-track, adherence groups, community pick-up points, home ART delivery, extended facility hours, facility multi-month dispensing (MMD, 4-6-month ART dispensing), frequent refill care (facility 1-2 month dispensing), and conventional care (facility 3 month dispensing, reference group). We used Fine and Gray competing risk regression to assess patient-level factors associated with attrition, stratified by sex and rural/urban setting. + Of 547,281 eligible patients, 68% (n = 372,409) enrolled in DSD models, most commonly facility MMD (n = 306,430, 82%), frequent refill care (n = 47,142, 13%), and fast track (n = 14,433, 4%), with <2% enrolled in the other DSD groups. Retention was higher in nearly all DSD models for all dispensing intervals, compared to the reference group, except fast track for the ≤2 month dispensing group. Retention benefits were greatest for patients in the extended clinic hours group and least for fast track dispensing. + Although retention in HIV treatment differed by DSD type, dispensing interval, and patient characteristics, nearly all DSD models out-performed conventional care. Understanding the factors that influence the retention of patients in DSD models could provide an important step towards improving DSD implementation. + Copyright: © 2023 Jo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Jo + Youngji + Y + + Department of Medicine, Section of Infectious Diseases, Boston Medical Center, Boston, MA, United States of America. + + + + Jamieson + Lise + L + + Department of Internal Medicine, Health Economics and Epidemiology Research Office, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. + + + Department of Medical Microbiology, Amsterdam University Medical Center, Amsterdam, Netherlands. + + + + Phiri + Bevis + B + + Clinton Health Access Initiative, Lusaka, Zambia. + + + + Grimsrud + Anna + A + https://orcid.org/0000-0002-1199-8377 + + HIV Programmes and Advocacy, International AIDS Society, Cape Town, South Africa. + + + + Mwansa + Muya + M + + Ministry of Health, Lusaka, Zambia. + + + + Shakwelele + Hilda + H + + Clinton Health Access Initiative, Lusaka, Zambia. + + + + Haimbe + Prudence + P + + Clinton Health Access Initiative, Lusaka, Zambia. + + + + Mukumbwa-Mwenechanya + Mpande + M + + Centre for Infectious Disease Research in Zambia, Lusaka, Zambia. + + + + Mulenga + Priscilla Lumano + PL + + Ministry of Health, Lusaka, Zambia. + + + + Nichols + Brooke E + BE + + Department of Internal Medicine, Health Economics and Epidemiology Research Office, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. + + + Department of Medical Microbiology, Amsterdam University Medical Center, Amsterdam, Netherlands. + + + Department of Global Health, Boston University School of Public Health, Boston, MA, United States of America. + + + + Rosen + Sydney + S + https://orcid.org/0000-0002-6560-2964 + + Department of Internal Medicine, Health Economics and Epidemiology Research Office, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. + + + Department of Global Health, Boston University School of Public Health, Boston, MA, United States of America. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 07 + 07 + + + 2023 + 01 + 07 + + + 2023 + 3 + 14 + 13 + 33 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917568 + 10.1371/journal.pone.0280748 + PONE-D-22-19252 + + +
+ + + 36917584 + + 2023 + 03 + 14 + +
+ + 1932-6203 + + 18 + 3 + + 2023 + + + PloS one + PLoS One + + Effects of different cardiopulmonary resuscitation education interventions among university students: A randomized controlled trial. + + e0283099 + + 10.1371/journal.pone.0283099 + + Cardiopulmonary resuscitation (CPR) education for the public may improve bystander intention to perform CPR on cardiac arrest patients. Studies have shown that different CPR education intervention methods can improve learning performance, with key indicators including attitude toward to CPR, intention to perform CPR, and degree of CPR knowledge and skills. The present study compared the traditional face-to-face method to hybrid and virtual reality (VR) methods to observe difference in learning performance and length of performance retention. This study adopted randomized controlled trial to compare CPR learning performance between traditional face-to-face, hybrid, and VR methods. Participants from each intervention group completed a pretest and 2 posttests. The measurement tools included an attitude and intention questionnaire, knowledge examination, and skill examination with a RESUSCI ANNE QCPR ® manikin. The performance among all participants in pretest showed no significant difference between the intervention groups, indicating no difference in their background attitude, knowledge, and skill level. Significant differences were observed in the average degree of intention to perform CPR between the hybrid and traditional groups in 1st and 2nd posttest. Compared to the pretest results, the posttests revealed significantly higher attitude toward CPR, intention to perform CPR, knowledge examination results, accuracy of overall chest compression, accuracy of CPR procedure, accuracy of AED usage, accuracy of chest compression rate, and accuracy of chest compression depth. The average time to reattending CPR learning and practice session was 11-12 weeks reported by participants. The hybrid and VR methods to CPR education resulted in the same level of improvement in learning performance as traditional face-to-face teaching. The suggested frequency for renewing CPR knowledge and skills is 12 weeks which may be considered in new strategies aimed at promoting CPR education and exposure to the public. + Copyright: © 2023 Chang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Chang + Yu-Tung + YT + https://orcid.org/0000-0002-7540-6035 + + Department of Health Promotion and Health Education, National Taiwan Normal University, Taipei, Taiwan. + + + Department of Health Care Management, College of Health Technology, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan. + + + + Wu + Kun-Chia + KC + + Department of Medical VR, HTC Corporation, Taipei, Taiwan. + + + + Yang + Hsiang-Wen + HW + + Taiwan SAVEANNE Education Association, Taipei, Taiwan. + + + + Lin + Chung-Yi + CY + + Department of Shipping and Transportation Management, National Taiwan Ocean University, Keelong, Taiwan. + + + + Huang + Tzu-Fu + TF + + Department of Health Promotion and Health Education, National Taiwan Normal University, Taipei, Taiwan. + + + + Yu + Yi-Chi + YC + + Department of Health Promotion and Health Education, National Taiwan Normal University, Taipei, Taiwan. + + + + Hu + Yih-Jin + YJ + + Department of Health Promotion and Health Education, National Taiwan Normal University, Taipei, Taiwan. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 09 + 13 + + + 2023 + 03 + 01 + + + 2023 + 3 + 14 + 13 + 33 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917584 + 10.1371/journal.pone.0283099 + PONE-D-22-25358 + + +
+ + + 36917573 + + 2023 + 03 + 14 + +
+ + 1932-6203 + + 18 + 3 + + 2023 + + + PloS one + PLoS One + + Individual reflectance of solar radiation confers a thermoregulatory benefit to dimorphic males bees (Centris pallida) using distinct microclimates. + + e0271250 + + 10.1371/journal.pone.0271250 + + Incoming solar radiation (wavelengths 290-2500 nm) significantly affects an organism's thermal balance via radiative heat gain. Species adapted to different environments can differ in solar reflectance profiles. We hypothesized that conspecific individuals using thermally distinct microhabitats to engage in fitness-relevant behaviors would show intraspecific differences in reflectance: we predicted individuals that use hot microclimates (where radiative heat gain represents a greater thermoregulatory challenge) would be more reflective across the entire solar spectrum than those using cooler microclimates. Differences in near-infrared (NIR) reflectance (700-2500 nm) are strongly indicative of thermoregulatory adaptation as, unlike differences in visible reflectance (400-700 nm), they are not perceived by ecological or social partners. We tested these predictions in male Centris pallida (Hymenoptera: Apidae) bees from the Sonoran Desert. Male C. pallida use alternative reproductive tactics that are associated with distinct microclimates: Large-morph males, with paler visible coloration, behave in an extremely hot microclimate close to the ground, while small-morph males, with a dark brown dorsal coloration, frequently use cooler microclimates above the ground near vegetation. We found that large-morph males had higher reflectance of solar radiation (UV through NIR) resulting in lower solar absorption coefficients. This thermoregulatory adaptation was specific to the dorsal surface, and produced by differences in hair, not cuticle, characteristics. Our results showed that intraspecific variation in behavior, particular in relation to microclimate use, can generate unique thermal adaptations that changes the reflectance of shortwave radiation among individuals within the same population. + Copyright: © 2023 Barrett, O’Donnell. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Barrett + Meghan + M + https://orcid.org/0000-0002-1270-4983 + + Department of Biology, Drexel University, Philadelphia, PA, United States of America. + + + Department of Biology, California State University Dominguez Hills, Carson, CA, United States of America. + + + + O'Donnell + Sean + S + + Department of Biology, Drexel University, Philadelphia, PA, United States of America. + + + Department of Biodiversity, Earth, and Environmental Sciences, Drexel University, Philadelphia, PA, United States of America. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 06 + 25 + + + 2023 + 02 + 28 + + + 2023 + 3 + 14 + 13 + 33 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917573 + 10.1371/journal.pone.0271250 + PONE-D-22-18125 + + +
+ + + 36917570 + + 2023 + 03 + 14 + +
+ + 1549-1676 + + 20 + 3 + + 2023 + Mar + + + PLoS medicine + PLoS Med + + The future of HIV testing in eastern and southern Africa: Broader scope, targeted services. + + e1004182 + + 10.1371/journal.pmed.1004182 + + In this Policy Forum, Anna Grimsrud and colleagues discuss the future of HIV testing in eastern and southern Africa, using insights gleaned from a 2021 expert consultation. + Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. + + + + Grimsrud + Anna + A + https://orcid.org/0000-0002-1199-8377 + + IAS-International AIDS Society, Cape Town, Western Cape, South Africa. + + + + Wilkinson + Lynne + L + + IAS-International AIDS Society, Cape Town, Western Cape, South Africa. + + + University of Cape Town, Cape Town, South Africa. + + + + Ehrenkranz + Peter + P + https://orcid.org/0000-0003-2028-4779 + + Bill & Melinda Gates Foundation, Seattle, Washington, United States of America. + + + + Behel + Stephanie + S + + Centres for Disease Control and Prevention, Atlanta, Georgia, United States of America. + + + + Chidarikire + Thato + T + + South Africa National Department of Health, Pretoria, Gauteng, South Africa. + + + + Chisenga + Tina + T + https://orcid.org/0000-0001-5546-2825 + + Zambia Ministry of Health, Lusaka, Zambia. + + + + Golin + Rachel + R + + Office of the Global AIDS Coordinator and Health Diplomacy, Washington DC, United States of America. + + + United States Agency for International Development, Washington DC, United States of America. + + + + Johnson + Cheryl Case + CC + + World Health Organization, Geneva, Switzerland. + + + + Milanga + Maureen + M + https://orcid.org/0000-0002-3856-0869 + + Health GAP, Nairobi, Kenya. + + + + Onyekwena + Obinna + O + + The Global Fund, Geneva, Switzerland. + + + + Sundaram + Maaya + M + + Bill & Melinda Gates Foundation, Seattle, Washington, United States of America. + + + + Wong + Vincent + V + + United States Agency for International Development, Washington DC, United States of America. + + + + Baggaley + Rachel + R + + World Health Organization, Geneva, Switzerland. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + PLoS Med + 101231360 + 1549-1277 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2023 + 3 + 14 + 13 + 33 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917570 + 10.1371/journal.pmed.1004182 + PMEDICINE-D-22-02985 + + +
+ + + 36917588 + + 2023 + 03 + 14 + +
+ + 1932-6203 + + 18 + 3 + + 2023 + + + PloS one + PLoS One + + Associated factors with adherence to preventive behaviors related to COVID-19 among medical students in the university of Monastir, Tunisia. + + e0280921 + + 10.1371/journal.pone.0280921 + + Medical students should act as a model for the community in terms of compliance with preventive practices toward COVID-19. The aim of this study was to assess adherence to preventive behaviors related to COVID-19 among medical students and to identify its associated factors. + We conducted a cross-sectional survey in October 2020 in the faculty of medicine of Monastir. We included a representative sample of medical students during registration days for the 2020-2021 academic year. The data were collected through a self-administered anonymous questionnaire. Eleven items related to preventive practices against COVID-19 were assessed (respiratory hygiene practices (Six Item), hand hygiene practices (Three Items) and social distancing (two items)). Items were evaluated using a Likert scale of five points (from 0: (Never) to 4: (Always)). The score obtained from the sum of these items allowed to classify students into two categories: "Good compliance" if the score was ≥ 80% and "Poor compliance" if the score was less than 80%. Scores were compared according to the study population characteristics. Multivariate analysis was used to identify associated factors with good practices. The threshold of statistical significance was set at p < 0.05. + We included 678 medical students. The average age was 21.76 (SD = 1.89 years) with a sex ratio of 0.40. The protection measures most respected by the participants were related to the respiratory hygiene: correct coverage of the nose and mouth with the mask (80%), wearing masks regardless of the presence of symptoms (73.3%) and coverage of the mouth during coughing or sneezing (76.6%). Adherence to hand hygiene measures ranged from 51.4% to 66.3%. The least respected measures were related to social distancing: distancing of at least one meter from others (31.2%) and avoiding crowded places (42.5%). An overall score ≥ 80% was obtained among 61.5% of students. Referring to multivariate analysis, variables that positively affected the overall score of preventive measures related to COVID-19 were the female sex and living alone, with Beta coefficients of 3.82 and 1.37 respectively. The perceived level of stress, E-cigarette and Chicha consumption negatively affected the score with Beta coefficients of (-0.13), (-5.11) and (-2.33) respectively. + The level of adherence to good practice among medical students was overall moderate. Awareness programs would be needed in this population, especially for men and those who smoke and vape. + Copyright: © 2023 Zemni et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Zemni + Imen + I + https://orcid.org/0000-0002-3273-7811 + + Department of Epidemiology and Preventive Medicine, Fattouma Bourguiba University Hospital, University of Monastir, Monastir, Tunisia. + + + Department of Epidemiology, Faculty of Medicine of Monastir, University of Monastir, Monastir, Tunisia. + + + Technology and Medical Imaging Research Laboratory-LTIM-LR12ES06, University of Monastir, Monastir, Tunisia. + + + + Zemni + Kaouthar + K + + Department of Epidemiology and Preventive Medicine, Fattouma Bourguiba University Hospital, University of Monastir, Monastir, Tunisia. + + + Department of Family Medicine, Faculty of Medicine of Monastir, University of Monastir, Monastir, Tunisia. + + + + Gara + Amal + A + + Department of Epidemiology and Preventive Medicine, Fattouma Bourguiba University Hospital, University of Monastir, Monastir, Tunisia. + + + Department of Epidemiology, Faculty of Medicine of Monastir, University of Monastir, Monastir, Tunisia. + + + + Maatouk + Amani + A + + Department of Epidemiology and Preventive Medicine, Fattouma Bourguiba University Hospital, University of Monastir, Monastir, Tunisia. + + + Department of Epidemiology, Faculty of Medicine of Monastir, University of Monastir, Monastir, Tunisia. + + + + Ben Fredj + Manel + M + + Department of Epidemiology and Preventive Medicine, Fattouma Bourguiba University Hospital, University of Monastir, Monastir, Tunisia. + + + Department of Epidemiology, Faculty of Medicine of Monastir, University of Monastir, Monastir, Tunisia. + + + Technology and Medical Imaging Research Laboratory-LTIM-LR12ES06, University of Monastir, Monastir, Tunisia. + + + + Abroug + Hela + H + + Department of Epidemiology and Preventive Medicine, Fattouma Bourguiba University Hospital, University of Monastir, Monastir, Tunisia. + + + Department of Epidemiology, Faculty of Medicine of Monastir, University of Monastir, Monastir, Tunisia. + + + Technology and Medical Imaging Research Laboratory-LTIM-LR12ES06, University of Monastir, Monastir, Tunisia. + + + + Kacem + Meriem + M + + Department of Epidemiology and Preventive Medicine, Fattouma Bourguiba University Hospital, University of Monastir, Monastir, Tunisia. + + + Department of Epidemiology, Faculty of Medicine of Monastir, University of Monastir, Monastir, Tunisia. + + + Technology and Medical Imaging Research Laboratory-LTIM-LR12ES06, University of Monastir, Monastir, Tunisia. + + + + Benasrallah + Cyrine + C + + Department of Epidemiology and Preventive Medicine, Fattouma Bourguiba University Hospital, University of Monastir, Monastir, Tunisia. + + + Department of Epidemiology, Faculty of Medicine of Monastir, University of Monastir, Monastir, Tunisia. + + + Technology and Medical Imaging Research Laboratory-LTIM-LR12ES06, University of Monastir, Monastir, Tunisia. + + + + Dhouib + Wafa + W + + Department of Epidemiology and Preventive Medicine, Fattouma Bourguiba University Hospital, University of Monastir, Monastir, Tunisia. + + + Department of Epidemiology, Faculty of Medicine of Monastir, University of Monastir, Monastir, Tunisia. + + + Technology and Medical Imaging Research Laboratory-LTIM-LR12ES06, University of Monastir, Monastir, Tunisia. + + + + Bouanene + Ines + I + + Department of Epidemiology and Preventive Medicine, Fattouma Bourguiba University Hospital, University of Monastir, Monastir, Tunisia. + + + Department of Epidemiology, Faculty of Medicine of Monastir, University of Monastir, Monastir, Tunisia. + + + + Belguith Sriha + Asma + A + + Department of Epidemiology and Preventive Medicine, Fattouma Bourguiba University Hospital, University of Monastir, Monastir, Tunisia. + + + Department of Epidemiology, Faculty of Medicine of Monastir, University of Monastir, Monastir, Tunisia. + + + Technology and Medical Imaging Research Laboratory-LTIM-LR12ES06, University of Monastir, Monastir, Tunisia. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 09 + 02 + + + 2022 + 12 + 27 + + + 2023 + 3 + 14 + 13 + 33 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917588 + 10.1371/journal.pone.0280921 + PONE-D-22-24560 + + +
+ + + 36917587 + + 2023 + 03 + 14 + +
+ + 1932-6203 + + 18 + 3 + + 2023 + + + PloS one + PLoS One + + Determinants of bank's efficiency in an emerging economy: A data envelopment analysis approach. + + e0281663 + + 10.1371/journal.pone.0281663 + + This study aims to assess the influence of internal and external factors on the Efficiency of banks in Pakistan using the Data Envelopment Analysis Approach (DEA). Bank's Efficiency is measured through DEA Model using input and output variables. The input variable includes the number of employees, number of branches, administration expenses, non-interest expenses, and loan loss provisions. In contrast, the output variable consists of net interest income, net commissions, and total other income. This study considers the internal determinants of the bank's Efficiency as corporate governance, enterprise risk management, ownership structure (state, foreign, and domestic ultimate owned banks), return on equity, financial leverage, and the size of the bank. The external determinants of the bank's Efficiency include banking structure and macroeconomic conditions. The study has used data from seventeen commercial banks over the period of 2011 to 2020. The study used the Data Envelopment Analysis Approach (DEA) and Logit and Probit Regression Model to evaluate research hypotheses. The Logit model results show that corporate governance, ultimate global ownership, and return on equity have a statistically significant and positive impact on the bank's Efficiency. Enterprise risk management and financial leverage adversely affect the bank's Efficiency. Better corporate governance can help banks to control the risk and cost of capital and enhancement the effectiveness of capital. Similarly, better risk management of banks can lead to better operational and strategic decisions in the competitive banking environment. + Copyright: © 2023 Ullah et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Ullah + Saif + S + https://orcid.org/0000-0002-1205-6250 + + Department of Management, Technology and Information Sciences, Faculty of Engineering, Sciences, Technology and Management at Ziauddin University, Karachi, Pakistan. + + + + Majeed + Abdul + A + https://orcid.org/0000-0001-5231-8756 + + Business School, Huanggang Normal University, Huanggang, Hubei, China. + + + + Popp + József + J + + John von Neumann University, Hungarian National Bank-Research Center, Kecskemét, Hungary. + + + College of Business and Economics, University of Johannesburg, Johannesburg, South Africa. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 11 + 10 + + + 2023 + 01 + 28 + + + 2023 + 3 + 14 + 13 + 33 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917587 + 10.1371/journal.pone.0281663 + PONE-D-22-31072 + + +
+ + + 36917586 + + 2023 + 03 + 14 + +
+ + 1932-6203 + + 18 + 3 + + 2023 + + + PloS one + PLoS One + + The visual design of urban multimedia portals. + + e0282712 + + 10.1371/journal.pone.0282712 + + In the visual design of a portal website, color is the first intuitive factor for users. It is relatively difficult for the designer of a city portal website to choose a color system that represents a city's unique color from among the many available options. Therefore, this study extracted a decision-making model of the urban color system, which can help decision-makers and designers choose among color systems, and then effectively design a portal website that conforms to local cultural attributes. The proposed method to solve the problem involved obtaining optimal color matching by performing weight analysis of colors through 123 sample color semantics, factor analysis, and a fuzzy analytic hierarchy process. Semantic analysis was used to classify colors into four categories of fashion, technology, calm, and dazzling. The fashion color matching scheme scored relatively high. Web page color matching schemes with a white background were popular, among which a white and green color matching scheme scored relatively high. At the same time, there are differences in color preferences between genders and cultures. This study is significant because it proposes a color decision model for portal websites, which provides a reference value that can also be applied to the selection of color schemes for other types of web pages in the future. + Copyright: © 2023 Wang, Zhang. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Wang + Lin + L + + Department of Product Design, Sanming University, Sanming, China. + + + + Zhang + Yi + Y + https://orcid.org/0000-0002-9738-7250 + + Division of Arts, Shenzhen University, Shenzhen, Guangdong, China. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + There are no conficts of interest in the content of this article. +
+ + + + 2022 + 05 + 23 + + + 2023 + 02 + 21 + + + 2023 + 3 + 14 + 13 + 33 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917586 + 10.1371/journal.pone.0282712 + PONE-D-22-14953 + + +
+ + + 36917583 + + 2023 + 03 + 14 + +
+ + 1932-6203 + + 18 + 3 + + 2023 + + + PloS one + PLoS One + + Prevalence and predictors of suicidal behaviours among primary and secondary school going adolescents in Botswana. + + e0282774 + + 10.1371/journal.pone.0282774 + + There is a scarcity of studies on the prevalence and predictors of suicide behaviors among primary and secondary school going adolescents aged 10-19 years in Botswana hence, this study would fill that gap. + This study used cross-sectional secondary data from Botswana Youth Risk Behavior and Biological Surveillance Survey (BYRBBSS), 2010. Multivariable binary logistic regression models were used to investigate the predictors of suicide behaviours. + The study shows that 51.5% of the respondents reported having ever contemplated suicide while 40.1% of the respondents attempted suicide in the last 12 months before the survey. The study found that male learners (AOR = 0.61, 95% CI = 0.44-0.83), learners who were not attacked or threatened or injured by someone (AOR = 0.35, 95% CI = 0.17-0.72), who were not bullied (AOR = 0.22, 95% CI = 0.13-0.39), and who were confident of themselves (AOR = 0.55, 95% CI = 0.39-0.76) were less likely to contemplate suicide. Whereas learners with primary school level education were more likely to contemplate suicide (AOR = 2.12, 95% CI = 1.14-3.95). Males were less likely than their female counterparts to attempt suicide (AOR = 0.68, 95% CI = 0.47-0.97). Regarding attempt, learners who had self-confidence (AOR = 0.35, 95% CI = 0.24-0.50), not being bullied (AOR = 0.20, 95% CI = 0.11-0.35), not being attacked or threatened or injured by someone (AOR = 0.35, 95% CI = 0.18-0.69), not engaging in a physical fight that led to injury (AOR = 0.34, 95% CI = 0.19-0.61) were less likely to attempt suicide. Whereas being at primary school (AOR = 5.29, 95% CI = 2.58-10.86), and missing classes once or more in a week (AOR = 1.70, 95% CI = 1.05-2.76) were associated with increased likelihood of suicide attempt. + The study shows that suicide behaviours as big challenges in Botswana among primary and secondary school going adolescents aged 10-19 years. Thus, the study recommends policy interventions aiming at including education on peer bullying or fighting or attack at primary and secondary education levels if not already in existence. There should also be interventions aiming at educating guardians and teachers on consequences of bullying or fighting so that they should consistently remind their children not to bully and for them to open up if they are being bullied. The study further recommends that schools and communities at large should have a psychosocial system for bullying or fighting reporting, follow-up, and appropriate corrective interventions for the offenders. There should also be self-confidence instilling education as well as sex/gender-specific interventions for instance girls can be given platform (private if necessary) to express peculiar problems to them that need specific help. + Copyright: © 2023 Forty et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Forty + James + J + https://orcid.org/0000-0002-7763-7443 + + African Institute for Development Policy, Lilongwe, Malawi. + + + + Navaneetham + Kannan + K + https://orcid.org/0000-0002-5847-4669 + + Department of Population Studies, University of Botswana, Gaborone, Botswana. + + + + Letamo + Gobopamang + G + + Department of Population Studies, University of Botswana, Gaborone, Botswana. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + NO authors have competing interests. +
+ + + + 2022 + 08 + 28 + + + 2023 + 02 + 22 + + + 2023 + 3 + 14 + 13 + 33 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917583 + 10.1371/journal.pone.0282774 + PONE-D-22-24013 + + +
+ + + 36917579 + + 2023 + 03 + 14 + +
+ + 1932-6203 + + 18 + 3 + + 2023 + + + PloS one + PLoS One + + Predicting biomass of resident kōkopu (Galaxias) populations using local habitat characteristics. + + e0261993 + + 10.1371/journal.pone.0261993 + + With the global decline of freshwater fishes, quantifying the body size-specific habitat use of vulnerable species is crucial for accurately evaluating population health, identifying the effects of anthropogenic stressors, and directing effective habitat restoration. Populations of New Zealand's endemic kōkopu species (Galaxias fasciatus, G. argenteus, and G. postvectis) have declined substantially over the last century in response to anthropogenic stressors, including habitat loss, migratory barriers, and invasive species. Despite well-understood habitat associations, key within-habitat features underpinning the reach-scale biomass of small and large kōkopu remain unclear. Here, we investigated whether the total biomass of large (> 90 mm) size classes of each kōkopu species and the composite biomass of all small (≤ 90 mm) kōkopu were associated with components of the physical environment that provided refuge and prey resources across fifty-seven 50-m stream reaches. Because kōkopu are nocturnal, populations were sampled by removal at night using headlamps and hand-nets until reaches were visually depleted. Based on Akaike's information criterion, greater large banded kōkopu biomass was most parsimoniously explained by greater pool volume and forest cover, greater large giant kōkopu biomass by greater bank cover and pool volume, and greater large shortjaw kōkopu biomass by greater substrate size and pool volume. In contrast, greater composite small kōkopu biomass was best explained by smaller substrate size, reduced bank cover, and greater pool volume. Local habitat associations therefore varied among kōkopu species and size classes. Our study demonstrates the importance of considering the ontogenetic shift in species' habitat use and provides an effective modelling approach for quantifying size-specific local habitat use of stream-dwelling fish. + Copyright: © 2023 Crichton et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Crichton + Ben R J + BRJ + https://orcid.org/0000-0001-9879-2576 + + Marine Ecology Research Group, School of Biological Sciences, University of Canterbury, Christchurch, New Zealand. + + + Freshwater Ecology Research Group, School of Biological Sciences, University of Canterbury, Christchurch, New Zealand. + + + + Hickford + Michael J H + MJH + + Marine Ecology Research Group, School of Biological Sciences, University of Canterbury, Christchurch, New Zealand. + + + National Institute of Water and Atmospheric Research, Christchurch, New Zealand. + + + + McIntosh + Angus R + AR + https://orcid.org/0000-0003-2696-8813 + + Freshwater Ecology Research Group, School of Biological Sciences, University of Canterbury, Christchurch, New Zealand. + + + + Schiel + David R + DR + + National Institute of Water and Atmospheric Research, Christchurch, New Zealand. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2021 + 12 + 14 + + + 2023 + 02 + 18 + + + 2023 + 3 + 14 + 13 + 33 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917579 + 10.1371/journal.pone.0261993 + PONE-D-21-39491 + + +
+ + + 36917580 + + 2023 + 03 + 14 + +
+ + 1932-6203 + + 18 + 3 + + 2023 + + + PloS one + PLoS One + + How food support improves mental health among people living with HIV: A qualitative study. + + e0282857 + + 10.1371/journal.pone.0282857 + + Food insecurity is associated with poor mental health among people living with HIV (PLHIV). This qualitative study explored the mental health experiences of PLHIV participating in a medically appropriate food support program. + Semi-structured interviews were conducted post-intervention (n = 34). Interview topics included changes, or lack thereof, in mental health and reasons for changes. Interviews were audio-recorded, transcribed, and double-coded. Salient themes were identified using an inductive-deductive method. + Positive changes in mental health self-reported by PLHIV included improved mood and reduced stress, worry, and anxiety. Participants attributed these changes to: 1) increased access to sufficient and nutritious foods, 2) increased social support, 3) reduced financial hardship, 4) increased sense of control and self-esteem, and 5) reduced functional barriers to eating. + Medically appropriate food support may improve mental health for some PLHIV. Further work is needed to understand and prevent possible adverse consequences on mental health after programs end. + Copyright: © 2023 Chayama et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Chayama + Koharu Loulou + KL + https://orcid.org/0000-0002-6496-7750 + + Department of Global Health Sciences, University of California, San Francisco, San Francisco, California, United States of America. + + + Interdisciplinary Studies Graduate Program, University of British Columbia, Vancouver, Canada. + + + British Columbia Centre on Substance Use, Vancouver, Canada. + + + + Hufstedler + Emiliano Lemus + EL + + San Francisco Joint Medical Program, University of California Berkeley-University of California, Berkeley, California, United States of America. + + + + Whittle + Henry J + HJ + + Division of Psychiatry, University College London, London, United Kingdom. + + + + Nápoles + Tessa M + TM + + Department of Social and Behavioral Sciences, University of California, San Francisco, San Francisco, California, United States of America. + + + Division of HIV, Department of Medicine, Infectious Diseases and Global Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, California, United States of America. + + + + Seligman + Hilary + H + https://orcid.org/0000-0003-2292-5189 + + Division of General Internal Medicine, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, California, United States of America. + + + + Madsen + Kimberly + K + + Project Open Hand, San Francisco, California, United States of America. + + + + Frongillo + Edward A + EA + https://orcid.org/0000-0002-8265-9815 + + Department of Health Promotion, Education, and Behavior, University of South Carolina, Columbia, South Carolina, United States of America. + + + + Weiser + Sheri D + SD + + Division of HIV, Department of Medicine, Infectious Diseases and Global Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, California, United States of America. + + + Center for AIDS Prevention Studies, University of California, San Francisco, San Francisco, California, United States of America. + + + + Palar + Kartika + K + + Division of HIV, Department of Medicine, Infectious Diseases and Global Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, California, United States of America. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have read the journal’s policy and the authors of this manuscript have the following competing interests: KM is a current employee at Project Open Hand. KL, ELH, HJW, TMN, HS, EAF, SDW, and KP report no competing interests. This does not alter our adherence to PLOS ONE policies on sharing data and materials. +
+ + + + 2022 + 01 + 31 + + + 2023 + 02 + 10 + + + 2023 + 3 + 14 + 13 + 33 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917580 + 10.1371/journal.pone.0282857 + PONE-D-22-03015 + + +
+ + + 36917581 + + 2023 + 03 + 14 + +
+ + 1553-7358 + + 19 + 3 + + 2023 + Mar + 14 + + + PLoS computational biology + PLoS Comput Biol + + Inferring feature importance with uncertainties with application to large genotype data. + + e1010963 + + 10.1371/journal.pcbi.1010963 + + Estimating feature importance, which is the contribution of a prediction or several predictions due to a feature, is an essential aspect of explaining data-based models. Besides explaining the model itself, an equally relevant question is which features are important in the underlying data generating process. We present a Shapley-value-based framework for inferring the importance of individual features, including uncertainty in the estimator. We build upon the recently published model-agnostic feature importance score of SAGE (Shapley additive global importance) and introduce Sub-SAGE. For tree-based models, it has the advantage that it can be estimated without computationally expensive resampling. We argue that for all model types the uncertainties in our Sub-SAGE estimator can be estimated using bootstrapping and demonstrate the approach for tree ensemble methods. The framework is exemplified on synthetic data as well as large genotype data for predicting feature importance with respect to obesity. + Copyright: © 2023 Johnsen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Johnsen + Pål Vegard + PV + https://orcid.org/0000-0002-2599-7914 + + SINTEF DIGITAL, Oslo, Norway. + + + Department of Mathematical Sciences, Norwegian University of Science and Technology, Trondheim, Norway. + + + + Strümke + Inga + I + + Department of Engineering Cybernetics, Norwegian University of Science and Technology, Trondheim, Norway. + + + Department of Holistic Systems, SimulaMet, Oslo, Norway. + + + + Langaas + Mette + M + https://orcid.org/0000-0002-5714-0288 + + Department of Mathematical Sciences, Norwegian University of Science and Technology, Trondheim, Norway. + + + + DeWan + Andrew Thomas + AT + + Department of Chronic Disease Epidemiology and Center for Perinatal, Pediatric and Environmental Epidemiology, Yale School of Public Health, New Haven, Connecticut, United States of America. + + + + Riemer-Sørensen + Signe + S + https://orcid.org/0000-0002-5308-7651 + + SINTEF DIGITAL, Oslo, Norway. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + PLoS Comput Biol + 101238922 + 1553-734X + + IM + The authors declare that they have no competing interests. +
+ + + + 2022 + 07 + 04 + + + 2023 + 02 + 20 + + + 2023 + 3 + 14 + 13 + 33 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917581 + 10.1371/journal.pcbi.1010963 + PCOMPBIOL-D-22-01012 + + +
+ + + 36917589 + + 2023 + 03 + 14 + +
+ + 1932-6203 + + 18 + 3 + + 2023 + + + PloS one + PLoS One + + Can children and adolescents with ADHD use attention to maintain verbal information in working memory? + + e0282896 + + 10.1371/journal.pone.0282896 + + Children and adolescents with attentional-deficit/hyperactivity disorder (ADHD) present deficits in working memory (WM), but accounts for this phenomenon are still lacking. In this study, we used two variations of a complex-span task to test whether a specific WM mechanism, attentional refreshing, causes these deficits. Attentional refreshing is a maintenance strategy based on the sequential switch of attention between maintaining and processing information in WM. Its use is evidenced by a decrease in recall performance proportional to the distraction of attention away from the memoranda. In this study, we designed two experiments requiring children and adolescents with ADHD symptoms to maintain sequences of letters for subsequent recall, while performing a distracting task. In Experiment 1, the distracting task consisted of reading digits aloud. In Experiment 2, it consisted in making spatial judgements. The pace of the distracting tasks was varied to manipulate the level of attentional distraction. We observed that recall in ADHD participants was higher in the distracting conditions that give attention more opportunity to refresh letters. Moreover, ADHD participants had a similar recall performance to their age-matched typically developing peers. This study shows first evidence that individuals with ADHD can use attention to maintain verbal information in WM and calls for more research to understand their WM development. + Copyright: © 2023 Superbia-Guimarães et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Superbia-Guimarães + Luísa + L + https://orcid.org/0000-0003-0310-7367 + + Department of Psychology, University of Psychology, Fribourg, Switzerland. + + + + Bader + Michel + M + + University Service of Child and Adolescent Psychiatry, University Hospital of Lausanne, Lausanne, Vaud, Switzerland. + + + + Camos + Valérie + V + + Department of Psychology, University of Psychology, Fribourg, Switzerland. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 10 + 20 + + + 2023 + 02 + 25 + + + 2023 + 3 + 14 + 13 + 34 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917589 + 10.1371/journal.pone.0282896 + PONE-D-22-29022 + + +
+ + + 36917582 + + 2023 + 03 + 14 + +
+ + 1932-6203 + + 18 + 3 + + 2023 + + + PloS one + PLoS One + + Oxidative stress, dysfunctional energy metabolism, and destabilizing neurotransmitters altered the cerebral metabolic profile in a rat model of simulated heliox saturation diving to 4.0 MPa. + + e0282700 + + 10.1371/journal.pone.0282700 + + The main objective of the present study was to determine metabolic profile changes in the brains of rats after simulated heliox saturated diving (HSD) to 400 meters of sea water compared to the blank controls. Alterations in the polar metabolome in the rat brain due to HSD were investigated in cortex, hippocampus, and striatum tissue samples by applying an NMR-based metabolomic approach coupled with biochemical detection in the cortex. The reduction in glutathione and taurine levels may hypothetically boost antioxidant defenses during saturation diving, which was also proven by the increased malondialdehyde level, the decreased superoxide dismutase, and the decreased glutathione peroxidase in the cortex. The concomitant decrease in aerobic metabolic pathways and anaerobic metabolic pathways comprised downregulated energy metabolism, which was also proven by the biochemical quantification of the metabolic enzymes Na-K ATPase and LDH in cerebral cortex tissue. The significant metabolic abnormalities of amino acid neurotransmitters, such as GABA, glycine, and aspartate, decreased aromatic amino acids, including tyrosine and phenylalanine, both of which are involved in the metabolism of dopamine and noradrenaline, which are downregulated in the cortex. Particularly, a decline in the level of N-acetyl aspartate is associated with neuronal damage. In summary, hyperbaric decompression of a 400 msw HSD affected the brain metabolome in a rat model, potentially including a broad range of disturbing amino acid homeostasis, metabolites related to oxidative stress and energy metabolism, and destabilizing neurotransmitter components. These disturbances may contribute to the neurochemical and neurological phenotypes of HSD. + Copyright: © 2023 Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Liu + Xia + X + + Department of Diving and Hyperbaric Medicine, Navy Medical Center of PLA, Naval Medical University (Second Military Medical University), Shanghai, China. + + + + Fang + Yiqun + Y + + Department of Diving and Hyperbaric Medicine, Navy Medical Center of PLA, Naval Medical University (Second Military Medical University), Shanghai, China. + + + + Xu + Jiajun + J + + Department of Diving and Hyperbaric Medicine, Navy Medical Center of PLA, Naval Medical University (Second Military Medical University), Shanghai, China. + + + + Yang + Tao + T + + Department of Diving and Hyperbaric Medicine, Navy Medical Center of PLA, Naval Medical University (Second Military Medical University), Shanghai, China. + + + + Xu + Ji + J + + Department of Diving and Hyperbaric Medicine, Navy Medical Center of PLA, Naval Medical University (Second Military Medical University), Shanghai, China. + + + + He + Jia + J + + Department of Diving and Hyperbaric Medicine, Navy Medical Center of PLA, Naval Medical University (Second Military Medical University), Shanghai, China. + + + + Liu + Wenwu + W + + Department of Diving and Hyperbaric Medicine, Navy Medical Center of PLA, Naval Medical University (Second Military Medical University), Shanghai, China. + + + + Yu + Xuhua + X + + Department of Diving and Hyperbaric Medicine, Navy Medical Center of PLA, Naval Medical University (Second Military Medical University), Shanghai, China. + + + + Wen + Yukun + Y + + Department of Diving and Hyperbaric Medicine, Navy Medical Center of PLA, Naval Medical University (Second Military Medical University), Shanghai, China. + + + + Zhang + Naixia + N + + Department of Analytical Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. + + + + Li + Ci + C + https://orcid.org/0000-0002-9572-1155 + + Department of Diving and Hyperbaric Medicine, Navy Medical Center of PLA, Naval Medical University (Second Military Medical University), Shanghai, China. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + NO authors have competing interests. +
+ + + + 2022 + 08 + 31 + + + 2023 + 02 + 21 + + + 2023 + 3 + 14 + 13 + 33 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917582 + 10.1371/journal.pone.0282700 + PONE-D-22-24369 + + +
+ + + 36917590 + + 2023 + 03 + 14 + +
+ + 1932-6203 + + 18 + 3 + + 2023 + + + PloS one + PLoS One + + The archaeological potential of the northern Luangwa Valley, Zambia: The Luwumbu basin. + + e0269209 + + 10.1371/journal.pone.0269209 + + The Luangwa Basin, Zambia, which forms part of the Zambezi drainage, is strategically located between the Central African plateau and the East African Rift system. The Luangwa River and major tributaries, such as the Luwumbu River, are perennial water sources supporting essential resources that sustain human communities and a rich and diverse fauna and flora. The archaeological record of Luangwa is relatively unknown, despite early archaeological exploration hinting at its potential. Recent research in the southern Luangwa valley, however, suggests that it preserves a long record of hominin occupation spanning the Early to Late Stone Age. The research described here details fieldwork carried out in northeastern Luangwa, in the Luwumbu Basin, that confirms that a relatively deep package of Quaternary deposits, containing evidence of the Stone Age occupation of the region persists in the upper piedmont zone. + Copyright: © 2023 Burke et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Burke + A + A + https://orcid.org/0000-0002-7033-7798 + + Dept. d'Anthropologie, Université de Montréal, Montréal, QC, Canada. + + + + Bisson + M + M + + Anthropology Dept., McGill University, Montréal, QC, Canada. + + + + Schilt + F + F + + Interdisciplinary Center for Archaeology and Evolution of Human Behavior (ICArEHB), FCHS, Universidade do Algarve, Faro, Portugal. + + + + Tolan + S + S + + Chipembele Conservation Centre, Mfuwe, Zambia. + + + + Museba + J + J + + National Heritage Conservation Commission, Northern Region, Kasama, Zambia. + + + + Drapeau + M S M + MSM + + Dept. d'Anthropologie, Université de Montréal, Montréal, QC, Canada. + + + + Aleman + J C + JC + + CNRS, IRD, INRA Coll France, CEREGE, Aix Marseille Univ, Aix-en-Provence, France. + + + + Peros + M C + MC + + Department of Environment and Geography, Bishop's University, Sherbrooke, QC, Canada. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 05 + 14 + + + 2022 + 12 + 14 + + + 2023 + 3 + 14 + 13 + 34 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917590 + 10.1371/journal.pone.0269209 + PONE-D-22-14083 + + +
+ + + 36917585 + + 2023 + 03 + 14 + +
+ + 0748-321X + + + 2023 + Mar + 13 + + + Journal of veterinary medical education + J Vet Med Educ + + Comparison of Attempts Needed for Veterinary Students to Reach Proficiency in a Basic and Advanced Robotic Simulator Task. + + e20220130 + + 10.3138/jvme-2022-0130 + + Surgical training of students is one of the most difficult aspects of veterinary medical education. Competing interests of house officers, owner's wishes, and ethical concerns have led to increasing use of inanimate models for basic surgical skills training. Robotic simulators have benefits for psychomotor training but have not been previously investigated in veterinary medicine. Understanding the necessary practice time for new training devices is important when determining their potential value. The aim of this study was to compare the number of attempts needed for veterinary students to reach proficiency in both a basic and advanced robotic simulator task, and to assess the predictive nature of performance variables. Each student performed a basic and advanced tasks on the Mimic dV-Trainer™ until proficiency was reached. Students required a median of eight attempts (95% CI = 7-8, range: 6-11) to reach proficiency for the basic task versus 22 attempts (95% CI = 20-26, range: 11-62) for the advanced task. The median time required to complete training for the basic and advanced task was 13.5 minutes (range: 8-24 minutes) and 26.5 minutes (range: 11-82 minutes) respectively. The difference in task attempts supports the training protocol and confirms proficiency can be attained in a short period of time. The number of attempts to reach proficiency correlated with specific performance variables which can be used by educators to aid in training students on a robotic simulator. Continued investigations on robotic simulators should be performed to investigate their use in improving psychomotor skills in veterinary students. + + + + Buote + Nicole J + NJ + 0000-0003-4623-3582 + + ACVS Founding Fellow Minimally Invasive Surgery (Soft Tissue), Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 USA. + + + + Fransson + Boel + B + + ACVS Founding Fellow Minimally Invasive Surgery (Soft Tissue), Department of Clinical Sciences, Washington State University, Pullman, WA 99164-6610. + + + + Rishniw + Mark + M + + Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 USA. + + + + eng + + Journal Article + + + 2023 + 03 + 13 + +
+ + Canada + J Vet Med Educ + 7610519 + 0748-321X + + IM + + educational methods + resident/intern education + student education + surgery + +
+ + + + 2023 + 3 + 14 + 13 + 33 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917585 + 10.3138/jvme-2022-0130 + + +
+ + + 36917591 + + 2023 + 03 + 14 + +
+ + 1932-6203 + + 18 + 3 + + 2023 + + + PloS one + PLoS One + + Regional impact of aging population on economic development in China: Evidence from panel threshold regression (PTR). + + e0282913 + + 10.1371/journal.pone.0282913 + + The aging population is a common problem faced by most countries in the world. This study uses 18 years (from 2002 to 2019) of panel data from 31 regions in China (excluding Hong Kong, Macao, and Taiwan Province), and establishes a panel threshold regression model to study the non-linear impact of the aging population on economic development. It is different from traditional research in that this paper divides 31 regions in China into three regions: Eastern, Central, and Western according to the classification standard of the National Bureau of Statistics of China and compares the different impacts of the aging population on economic development in the three regions. Although this study finds that the aging population promotes the economy of China's eastern, central, and western regions, different threshold variables have dramatically different influences. When the sum of export and import is the threshold variable, the impact of the aging population on the eastern and the central region of China is significantly larger than that of the western region of China. However, when the unemployment rate is the threshold variable, the impact of the aging population on the western region of China is dramatically higher than the other regions' impact. Thus, one of the contributions of this study is that if the local government wants to increase the positive impact of the aging population on the per capita GDP of China, the local governments of different regions should advocate more policies that align with their economic situation rather than always emulating policies from other regions. + Copyright: © 2023 Liang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Liang + Yifan + Y + + School of Business and Economics, Universiti Putra Malaysia, Selangor, Malaysia. + + + + Mazlan + Nur Syazwani + NS + https://orcid.org/0000-0002-3911-0974 + + School of Business and Economics, Universiti Putra Malaysia, Selangor, Malaysia. + + + + Mohamed + Azali Bin + AB + + School of Business and Economics, Universiti Putra Malaysia, Selangor, Malaysia. + + + + Mhd Bani + Nor Yasmin Binti + NYB + + School of Business and Economics, Universiti Putra Malaysia, Selangor, Malaysia. + + + + Liang + Bufan + B + + School of Economics, University of Bristol, Bristol, United Kingdom. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 09 + 08 + + + 2023 + 02 + 27 + + + 2023 + 3 + 14 + 13 + 34 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917591 + 10.1371/journal.pone.0282913 + PONE-D-22-25089 + + +
+ + + 36917592 + + 2023 + 03 + 14 + +
+ + 1932-6203 + + 18 + 3 + + 2023 + + + PloS one + PLoS One + + Examining neighborhood-level hot and cold spots of food insecurity in relation to social vulnerability in Houston, Texas. + + e0280620 + + 10.1371/journal.pone.0280620 + + Food insecurity is prevalent and associated with poor health outcomes, but little is known about its geographical nature. The aim of this study is to utilize geospatial modeling of individual-level food insecurity screening data ascertained in health care settings to test for neighborhood hot and cold spots of food insecurity in a large metropolitan area, and then compare these hot spot neighborhoods to cold spot neighborhoods in terms of the CDC's Social Vulnerability Index. In this cross-sectional secondary data analysis, we geocoded the home addresses of 6,749 unique participants screened for food insecurity at health care locations participating in CMS's Accountable Health Communities (AHC) Model, as implemented in Houston, TX. Next, we created census-tract level incidence profiles of positive food insecurity screens per 1,000 people. We used Anselin's Local Moran's I statistic to test for statistically significant census tract-level hot/cold spots of food insecurity. Finally, we utilized a Mann-Whitney-U test to compare hot spot tracts to cold spot tracts in relation to the CDC's Social Vulnerability Index. We found that hot spot tracts had higher overall social vulnerability index scores (P <0.001), higher subdomain scores, and higher percentages of individual variables like poverty (P <0.001), unemployment (P <0.001), limited English proficiency (P <0.001), and more. The combination of robust food insecurity screening data, geospatial modeling, and the CDC's Social Vulnerability Index offers a solid method to understand neighborhood food insecurity. + Copyright: © 2023 Ramphul et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Ramphul + Ryan + R + https://orcid.org/0000-0001-9415-223X + + Department of Epidemiology, Human Genetics & Environmental Sciences, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America. + + + + Highfield + Linda + L + + Department of Management, Policy and Community Health, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America. + + + + Sharma + Shreela + S + + Department of Epidemiology, Human Genetics & Environmental Sciences, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 04 + 15 + + + 2023 + 01 + 04 + + + 2023 + 3 + 14 + 13 + 34 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917592 + 10.1371/journal.pone.0280620 + PONE-D-22-11199 + + +
+ + + 36917593 + + 2023 + 03 + 14 + +
+ + 1932-6203 + + 18 + 3 + + 2023 + + + PloS one + PLoS One + + Establishing evidence to inform culturally competent mental health services: A mixed methods study protocol. + + e0282445 + + 10.1371/journal.pone.0282445 + + COVID-19 has exacerbated the significant and longstanding mental health inequalities for ethnic minorities, who were less likely to access mental health support in primary care but more likely to end up in crisis care compared to the majority ethnic group. Services were poorly offered and accessed to respond to the increased mental health challenges. + To 1) establish evidence on which changes to mental health services provided in response to COVID-19 are beneficial for ethnic minorities who experience mental health difficulties in the North of England, and 2) to inform what and how culturally competent mental health services should be routinely provided. + A mixed methods approach comprising 1) a rapid review to map services and models of care designed or adjusted for mental health during the pandemic, 2) an observational study of retrospective routine data to assess changes to mental health services and associated outcomes, 3) qualitative interviews to understand experiences of seeking care and factors associated with high-quality service provision, and 4) a Delphi study to establish consensus on key features of culturally competent services. From the selected areas in the North of England, adults from ethnic minorities who experience mental health difficulties will be identified from the primary, community and secondary care services and local ethnic minority communities. + This study will identify ways to tackle health inequalities and contribute to mental health service recovery post pandemic by providing practice recommendations on equitable and effective services to ensure culturally competent and high-quality care. A list of services and features on what and how mental health services will be provided. Working with study collaborators and public and patient involvement partners, the study findings will be widely disseminated through presentations, conferences and publications and will inform the subsequent funding application for intervention development and evaluation. + Copyright: © 2023 Yu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Yu + Ge + G + https://orcid.org/0000-0002-0891-2501 + + Population Health Sciences Institute, Newcastle University, Newcastle, United Kingdom. + + + NIHR Applied Research Collaborative North East and North Cumbria, Cumbria, Northumberland and Tyne and Wear NHS Foundation Trust, Gosforth, Newcastle upon Tyne, United Kingdom. + + + + Panagioti + Maria + M + + Centre for Primary Care and Health Services Research, University of Manchester, Manchester, United Kingdom. + + + + Tang + Eugene Y H + EYH + + Population Health Sciences Institute, Newcastle University, Newcastle, United Kingdom. + + + + Robinson + Damian + D + + North East and North Cumbria, Cumbria, Northumberland and Tyne and Wear NHS Foundation Trust, Gosforth, Newcastle upon Tyne, United Kingdom. + + + + Husain + Nusrat + N + + Mersey Care NHS Foundation Trust, Prescot, United Kingdom. + + + + Lasrado + Reena + R + + Division of Nursing, Midwifery & Social Work, University of Manchester, Manchester, United Kingdom. + + + + Lovell + Karina + K + + Division of Nursing, Midwifery & Social Work, University of Manchester, Manchester, United Kingdom. + + + NIHR Applied Research Collaborative Greater Manchester, Manchester University NHS Foundation Trust, Manchester, United Kingdom. + + + + Kaner + Eileen + E + + Population Health Sciences Institute, Newcastle University, Newcastle, United Kingdom. + + + NIHR Applied Research Collaborative North East and North Cumbria, Cumbria, Northumberland and Tyne and Wear NHS Foundation Trust, Gosforth, Newcastle upon Tyne, United Kingdom. + + + + Fu + Yu + Y + https://orcid.org/0000-0003-4972-0626 + + Population Health Sciences Institute, Newcastle University, Newcastle, United Kingdom. + + + NIHR Applied Research Collaborative North East and North Cumbria, Cumbria, Northumberland and Tyne and Wear NHS Foundation Trust, Gosforth, Newcastle upon Tyne, United Kingdom. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2023 + 02 + 02 + + + 2023 + 02 + 13 + + + 2023 + 3 + 14 + 13 + 34 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917593 + 10.1371/journal.pone.0282445 + PONE-D-23-03010 + + +
+ + + 36917595 + + 2023 + 03 + 14 + +
+ + 1553-7404 + + 19 + 3 + + 2023 + Mar + 14 + + + PLoS genetics + PLoS Genet + + A sleep-active neuron can promote survival while sleep behavior is disturbed. + + e1010665 + + 10.1371/journal.pgen.1010665 + + Sleep is controlled by neurons that induce behavioral quiescence and physiological restoration. It is not known, however, how sleep neurons link sleep behavior and survival. In Caenorhabditis elegans, the sleep-active RIS neuron induces sleep behavior and is required for survival of starvation and wounding. Sleep-active neurons such as RIS might hypothetically promote survival primarily by causing sleep behavior and associated conservation of energy. Alternatively, RIS might provide a survival benefit that does not depend on behavioral sleep. To probe these hypotheses, we tested how activity of the sleep-active RIS neuron in Caenorhabditis elegans controls sleep behavior and survival during larval starvation. To manipulate the activity of RIS, we expressed constitutively active potassium channel (twk-18gf and egl-23gf) or sodium channel (unc-58gf) mutant alleles in this neuron. Low levels of unc-58gf expression in RIS increased RIS calcium transients and sleep. High levels of unc-58gf expression in RIS elevated baseline calcium activity and inhibited calcium activation transients, thus locking RIS activity at a high but constant level. This manipulation caused a nearly complete loss of sleep behavior but increased survival. Long-term optogenetic activation also caused constantly elevated RIS activity and a small trend towards increased survival. Disturbing sleep by lethal blue-light stimulation also overactivated RIS, which again increased survival. FLP-11 neuropeptides were important for both, induction of sleep behavior and starvation survival, suggesting that FLP-11 might have divergent roles downstream of RIS. These results indicate that promotion of sleep behavior and survival are separable functions of RIS. These two functions may normally be coupled but can be uncoupled during conditions of strong RIS activation or when sleep behavior is impaired. Through this uncoupling, RIS can provide survival benefits under conditions when behavioral sleep is disturbed. Promoting survival in the face of impaired sleep might be a general function of sleep neurons. + Copyright: © 2023 Busack, Bringmann. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Busack + Inka + I + https://orcid.org/0000-0001-8410-0006 + + BIOTEC, Technical University Dresden, Dresden, Germany. + + + + Bringmann + Henrik + H + https://orcid.org/0000-0002-7689-8617 + + BIOTEC, Technical University Dresden, Dresden, Germany. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + PLoS Genet + 101239074 + 1553-7390 + + IM + None. +
+ + + + 2022 + 01 + 26 + + + 2023 + 02 + 13 + + + 2023 + 3 + 14 + 13 + 34 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917595 + 10.1371/journal.pgen.1010665 + PGENETICS-D-22-00093 + + +
+ + + 36917596 + + 2023 + 03 + 14 + +
+ + 1932-6203 + + 18 + 3 + + 2023 + + + PloS one + PLoS One + + Healthcare worker access to molnupiravir: A case series. + + e0282695 + + 10.1371/journal.pone.0282695 + + Molnupiravir, an oral antiviral shown to reduce COVID-19 severity, is available in Australia via the Pharmaceutical Benefits Scheme (PBS) for treatment of mild-moderate COVID-19. For people less than 70 years of age it is only available with risk factors for severe disease, hence the majority of healthcare workers do not qualify. Currently, Australian health services are under considerable strain due to COVID-related staff shortages. Thirty staff members of a tertiary hospital, not eligible under the PBS, were offered molnupiravir within the first five days of COVID-19 illness. Their median age was 43 years, and 73% were female. All completed treatment with rates of adverse events that were low and comparable with clinical trial data. The reported duration of illness ranged from 1-16 days with a median of four days. A negative rapid antigen test on the final day of treatment was reported in 81% of people, and 73% reported being well enough to return to work at the completion of mandatory isolation. Only 22% of people reported transmission in their household after they commenced treatment. The implementation of a policy allowing access to molnupiravir outside of PBS recommendations for healthcare workers with mild-moderate COVID-19 may have important individual benefits to workers health and wellbeing and help alleviate the acute staff shortages experienced currently by the Australian healthcare workforce. + Copyright: © 2023 O’Keeffe et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + O'Keeffe + Jessica C + JC + https://orcid.org/0000-0002-0293-3221 + + Department of Infectious Diseases, Barwon Health, Geelong, Victoria, Australia. + + + Barwon South West Public Health Unit, Barwon Health, Geelong, Victoria, Australia. + + + + Constable + Meg + M + + StaffCare, Barwon Health, Geelong, Victoria, Australia. + + + + Chiang + Janice + J + + Pharmacy Department, Barwon Health, Geelong, Victoria, Australia. + + + + Somerville + Margaret + M + + StaffCare, Barwon Health, Geelong, Victoria, Australia. + + + + Yerramilli + Arvind + A + + Department of Infectious Diseases, Barwon Health, Geelong, Victoria, Australia. + + + Barwon South West Public Health Unit, Barwon Health, Geelong, Victoria, Australia. + + + + Nolan + Ross + R + + StaffCare, Barwon Health, Geelong, Victoria, Australia. + + + + Weeks + Greg + G + + Pharmacy Department, Barwon Health, Geelong, Victoria, Australia. + + + + O'Brien + Daniel P + DP + + Department of Infectious Diseases, Barwon Health, Geelong, Victoria, Australia. + + + Barwon South West Public Health Unit, Barwon Health, Geelong, Victoria, Australia. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 11 + 23 + + + 2023 + 02 + 19 + + + 2023 + 3 + 14 + 13 + 34 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917596 + 10.1371/journal.pone.0282695 + PONE-D-22-32276 + + +
+ + + 36917594 + + 2023 + 03 + 14 + +
+ + 1530-0293 + + + 2023 + Mar + 14 + + + Critical care medicine + Crit Care Med + + Immune Profiling Panel Gene Set Identifies Critically Ill Patients With Low Monocyte Human Leukocyte Antigen-DR Expression: Preliminary Results From the REAnimation Low Immune Status Marker (REALISM) Study. + 10.1097/CCM.0000000000005832 + + There is a crucial unmet need for biomarker-guided diagnostic and prognostic enrichment in clinical trials evaluating immune modulating therapies in critically ill patients. Low monocyte expression of human leukocyte antigen-DR (mHLA-DR), considered as a reference surrogate to identify immunosuppressed patients, has been proposed for patient stratification in immunostimulation approaches. However, its widespread use in clinic has been somewhat hampered by technical constraints inherent to flow cytometry technology. The objective of the present study was to evaluate the ability of a prototype multiplex polymerase chain reaction tool (immune profiling panel [IPP]) to identify immunosuppressed ICU patients characterized by a low mHLA-DR expression. + Retrospective observational cohort study. + Adult ICU in a University Hospital, Lyon, France. + Critically ill patients with various etiologies enrolled in the REAnimation Low Immune Status Marker study (NCT02638779). + None. + mHLA-DR and IPP data were obtained from 1,731 blood samples collected from critically ill patients with various etiologies and healthy volunteers. A partial least square regression model combining the expression levels of IPP markers was trained and used for the identification of samples from patients presenting with evidence of immunosuppression, defined here as mHLADR less than 8,000 antibodies bound per cell (AB/C). The IPP gene set had an area under the receiver operating characteristic curve (AUC) of 0.86 (95% CI 0.83-0.89) for the identification of immunosuppressed patients. In addition, when applied to the 123 patients still in the ICU at days 5-7 after admission, IPP similarly enriched the number of patients with ICU-acquired infections in the immunosuppressed group (26%), in comparison with low mHLA-DR (22%). + This study reports on the potential of the IPP gene set to identify ICU patients presenting with mHLA-DR less than 8,000 AB/C. Upon further optimization and validation, this molecular tool may help in the stratification of patients that could benefit from immunostimulation in the context of personalized medicine. + Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. + + + + Peronnet + Estelle + E + + Joint Research Unit HCL-bioMérieux, EA 7426 "Pathophysiology of Injury-Induced Immunosuppression" (Université Claude Bernard Lyon 1 - Hospices Civils de Lyon, bioMérieux), Lyon, France. + + + Open Innovation and Partnerships (OI&P), bioMérieux S.A., Marcy l'Etoile, France. + + + + Blein + Sophie + S + + Data Science, bioMérieux S.A., Marcy l'Etoile, France. + + + + Venet + Fabienne + F + + Immunology Laboratory, Edouard Herriot Hospital - Hospices Civils de Lyon, Lyon, France. + + + Centre International de Recherche en Infectiologie (CIRI), Inserm U1111, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Université Claude Bernard-Lyon 1, Lyon, France. + + + + Cerrato + Elisabeth + E + + Joint Research Unit HCL-bioMérieux, EA 7426 "Pathophysiology of Injury-Induced Immunosuppression" (Université Claude Bernard Lyon 1 - Hospices Civils de Lyon, bioMérieux), Lyon, France. + + + Open Innovation and Partnerships (OI&P), bioMérieux S.A., Marcy l'Etoile, France. + + + + Fleurie + Aurore + A + + Joint Research Unit HCL-bioMérieux, EA 7426 "Pathophysiology of Injury-Induced Immunosuppression" (Université Claude Bernard Lyon 1 - Hospices Civils de Lyon, bioMérieux), Lyon, France. + + + Open Innovation and Partnerships (OI&P), bioMérieux S.A., Marcy l'Etoile, France. + + + + Llitjos + Jean-François + JF + + Joint Research Unit HCL-bioMérieux, EA 7426 "Pathophysiology of Injury-Induced Immunosuppression" (Université Claude Bernard Lyon 1 - Hospices Civils de Lyon, bioMérieux), Lyon, France. + + + Open Innovation and Partnerships (OI&P), bioMérieux S.A., Marcy l'Etoile, France. + + + Department of Anaesthesia and Critical Care Medicine, Hospices Civils de Lyon, Edouard Herriot Hospital, Lyon, France. + + + + Kreitmann + Louis + L + + Joint Research Unit HCL-bioMérieux, EA 7426 "Pathophysiology of Injury-Induced Immunosuppression" (Université Claude Bernard Lyon 1 - Hospices Civils de Lyon, bioMérieux), Lyon, France. + + + + Terraz + Gabriel + G + + Joint Research Unit HCL-bioMérieux, EA 7426 "Pathophysiology of Injury-Induced Immunosuppression" (Université Claude Bernard Lyon 1 - Hospices Civils de Lyon, bioMérieux), Lyon, France. + + + + Conti + Filippo + F + + Joint Research Unit HCL-bioMérieux, EA 7426 "Pathophysiology of Injury-Induced Immunosuppression" (Université Claude Bernard Lyon 1 - Hospices Civils de Lyon, bioMérieux), Lyon, France. + + + + Gossez + Morgane + M + + Immunology Laboratory, Edouard Herriot Hospital - Hospices Civils de Lyon, Lyon, France. + + + Centre International de Recherche en Infectiologie (CIRI), Inserm U1111, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Université Claude Bernard-Lyon 1, Lyon, France. + + + + Rimmelé + Thomas + T + + Joint Research Unit HCL-bioMérieux, EA 7426 "Pathophysiology of Injury-Induced Immunosuppression" (Université Claude Bernard Lyon 1 - Hospices Civils de Lyon, bioMérieux), Lyon, France. + + + Department of Anaesthesia and Critical Care Medicine, Hospices Civils de Lyon, Edouard Herriot Hospital, Lyon, France. + + + + Textoris + Julien + J + + Joint Research Unit HCL-bioMérieux, EA 7426 "Pathophysiology of Injury-Induced Immunosuppression" (Université Claude Bernard Lyon 1 - Hospices Civils de Lyon, bioMérieux), Lyon, France. + + + Medical Affairs, bioMérieux S.A., Marcy l'Etoile, France. + + + + Lukaszewicz + Anne-Claire + AC + + Joint Research Unit HCL-bioMérieux, EA 7426 "Pathophysiology of Injury-Induced Immunosuppression" (Université Claude Bernard Lyon 1 - Hospices Civils de Lyon, bioMérieux), Lyon, France. + + + Department of Anaesthesia and Critical Care Medicine, Hospices Civils de Lyon, Edouard Herriot Hospital, Lyon, France. + + + + Brengel-Pesce + Karen + K + + Joint Research Unit HCL-bioMérieux, EA 7426 "Pathophysiology of Injury-Induced Immunosuppression" (Université Claude Bernard Lyon 1 - Hospices Civils de Lyon, bioMérieux), Lyon, France. + + + Open Innovation and Partnerships (OI&P), bioMérieux S.A., Marcy l'Etoile, France. + + + + Monneret + Guillaume + G + + Joint Research Unit HCL-bioMérieux, EA 7426 "Pathophysiology of Injury-Induced Immunosuppression" (Université Claude Bernard Lyon 1 - Hospices Civils de Lyon, bioMérieux), Lyon, France. + + + Immunology Laboratory, Edouard Herriot Hospital - Hospices Civils de Lyon, Lyon, France. + + + + REAnimation Low Immune Status Marker (REALISM) Study Group + + + eng + + + ClinicalTrials.gov + + NCT02638779 + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Crit Care Med + 0355501 + 0090-3493 + + IM + Drs. Peronnet, Blein, Cerrato, Fleurie, Llitjos, Textoris, and Brengel-Pesce are employees of bioMérieux. Drs. Peronnet, Cerrato, Fleurie, Llitjos, Kreitmann, Terraz, Conti, Rimmelé, Lukaszewicz, Brengel-Pesce, and Monneret work in a joint research unit, cofunded by the Hospices Civils de Lyon and bioMérieux. Drs. Peronnet, Venet, and Monneret are coinventors in patent applications covering the following markers: CX3CR1 and S100A9. Drs. Peronnet, Venet, Rimmelé, Textoris, and Monneret are coinventors in patent applications covering the following markers: CX3CR1, IL1R2, C3AR1, CD177, CIITA, and TAP2. BioFire—a bioMérieux company—holds patents on the technology. This does not alter the authors’ adherence to all the policies on sharing data and materials. Drs. Peronnet’s, Blein’s, Cerrato’s, Fleurie’s, Llitjos’, Terraz’s, and Lukaszewicz’s institutions received funding from the Agence Nationale de la Recherche; they received support for article research from bioMérieux, Sanofi, and GlaxoSmithKline. Drs. Peronnet, Blein, Cerrato, Fleurie, Kreitmann, Terraz, Textoris, and Brengel-Pesce received funding from bioMérieux. Drs. Peronnet, Cerrato, and Lukaszewicz disclosed that they are coinventors on patent applications. Dr. Peronnet disclosed that her partner is employed by bioMérieux. The remaining authors have disclosed that they do not have any potential conflict of interest. + + + Arnal + Sophie + S + + + Augris-Mathieu + Caroline + C + + + Bayle + Frederique + F + + + Caruso + Liana + L + + + Ber + Charles-Eric + CE + + + Ben-Amor + Asma + A + + + Bellocq + Anne-Sophie + AS + + + Benatir + Farida + F + + + Bertin-Maghit + Anne + A + + + Bertin-Maghit + Marc + M + + + Boibieux + Andre + A + + + Bouffard + Yves + Y + + + Cejka + Jean-Christophe + JC + + + Cerro + Valerie + V + + + Crozon-Clauzel + Jullien + J + + + Davidson + Julien + J + + + Debord-Peguet + Sophie + S + + + Delwarde + Benjamin + B + + + Deleat-Besson + Robert + R + + + Delsuc + Claire + C + + + Devigne + Bertrand + B + + + Fayolle-Pivot + Laure + L + + + Faure + Alexandre + A + + + Floccard + Bernard + B + + + Gatel + Julie + J + + + Genin + Charline + C + + + Girardot + Thibaut + T + + + Gregoire + Arnaud + A + + + Hengy + Baptiste + B + + + Huriaux + Laetitia + L + + + Jadaud + Catherine + C + + + Lepape + Alain + A + + + Leray + Veronique + V + + + Lukaszewicz + Anne-Claire + AC + + + Marcotte + Guillaume + G + + + Martin + Olivier + O + + + Matray + Marie + M + + + Maucort-Boulch + Delphine + D + + + Meuret + Pascal + P + + + Monard + Celine + C + + + Moriceau + Florent + F + + + Monneret + Guillaume + G + + + Panel + Nathalie + N + + + Rahali + Najia + N + + + Rimmele + Thomas + T + + + Truc + Cyrille + C + + + Uberti + Thomas + T + + + Vallin + Helene + H + + + Venet + Fabienne + F + + + Tissot + Sylvie + S + + + Zadam + Abbes + A + + + Blein + Sophie + S + + + Brengel-Pesce + Karen + K + + + Cerrato + Elisabeth + E + + + Cheynet + Valerie + V + + + Gallet-Gorius + Emmanuelle + E + + + Guichard + Audrey + A + + + Jourdan + Camille + C + + + Koenig + Natacha + N + + + Mallet + Francois + F + + + Meunier + Boris + B + + + Moucade + Virginie + V + + + Mommert + Marine + M + + + Oriol + Guy + G + + + Pachot + Alexandre + A + + + Peronnet + Estelle + E + + + Schrevel + Claire + C + + + Tabone + Olivier + O + + + Textoris + Julien + J + + + Marcos + Javier Yugueros + JY + + + Becker + Jeremie + J + + + Bequet + Frederic + F + + + Bounab + Yacine + Y + + + Brajon + Florian + F + + + Canard + Bertrand + B + + + Collus + Muriel + M + + + Garcon + Nathalie + N + + + Gorse + Irene + I + + + Guyard + Cyril + C + + + Lavocat + Fabien + F + + + Leissner + Philippe + P + + + Louis + Karen + K + + + Mistretta + Maxime + M + + + Moriniere + Jeanne + J + + + Mouscaz + Yoann + Y + + + Noailles + Laura + L + + + Perret + Magali + M + + + Reynier + Frederic + F + + + Riffaud + Cindy + C + + + Rol + Mary-Luz + ML + + + Sapay + Nicolas + N + + + Tran + Trang + T + + + Vedrine + Christophe + C + + + Carre + Christophe + C + + + Cortez + Pierre + P + + + de Monfort + Aymeric + A + + + Florin + Karine + K + + + Fraisse + Laurent + L + + + Fugier + Isabelle + I + + + Payrard + Sandrine + S + + + Peleraux + Annick + A + + + Quemeneur + Laurence + L + + + Griffiths + Andrew + A + + + Toetsch + Stephanie + S + + + Ashton + Teri + T + + + Gough + Peter J + PJ + + + Berger + Scott B + SB + + + Gardiner + David + D + + + Gillespie + Iain + I + + + Macnamara + Aidan + A + + + Raychaudhuri + Aparna + A + + + Smylie + Rob + R + + + Tan + Lionel + L + + + Tipple + Craig + C + + +
+ + + + 2023 + 3 + 14 + 13 + 34 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917594 + 10.1097/CCM.0000000000005832 + 00003246-990000000-00106 + + + + Marshall JC: Why have clinical trials in sepsis failed? Trends Mol Med 2014; 20:195–203 + + + Cavaillon JM, Annane D: Compartmentalization of the inflammatory response in sepsis and SIRS. J Endotoxin Res 2006; 12:151–170 + + + Torres LK, Pickkers P, van der Poll T: Sepsis-induced immunosuppression. Annu Rev Physiol 2022; 84:157–181 + + + Hotchkiss RS, Monneret G, Payen D: Sepsis-induced immunosuppression: From cellular dysfunctions to immunotherapy. Nat Rev Immunol 2013; 13:862–874 + + + Venet F, Textoris J, Blein S, et al.: Immune profiling demonstrates a common immune signature of delayed acquired immunodeficiency in patients with various etiologies of severe injury. Crit Care Med 2021; 50:565–575 + + + Meisel C, Schefold JC, Pschowski R, et al.: Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: A double-blind, randomized, placebo-controlled multicenter trial. Am J Respir Crit Care Med 2009; 180:640–648 + + + Tawfik DM, Vachot L, Bocquet A, et al.: Immune profiling panel: A proof-of-concept study of a new multiplex molecular tool to assess the immune status of critically ill patients. J Infect Dis 2020; 222(Supplement_2):S84–S95 + + + Rol ML, Venet F, Rimmele T, et al.; REALISM Study Group: The reanimation low immune status markers (REALISM) project: A protocol for broad characterisation and follow-up of injury-induced immunosuppression in intensive care unit (ICU) critically ill patients. BMJ Open 2017; 7:e015734 + + + Poritz MA, Blaschke AJ, Byington CL, et al.: FilmArray, an automated nested multiplex PCR system for multi-pathogen detection: Development and application to respiratory tract infection. PLoS One 2011; 6:e26047 + + + Demaret J, Venet F, Plassais J, et al.: Identification of CD177 as the most dysregulated parameter in a microarray study of purified neutrophils from septic shock patients. Immunol Lett 2016; 178:122–130 + + + Scicluna BP, van Vught LA, Zwinderman AH, et al.: Classification of patients with sepsis according to blood genomic endotype: A prospective cohort study. Lancet Respir Med 2017; 5:816–826 + + + Fontaine M, Planel S, Peronnet E, et al.: S100A8/A9 mRNA induction in an ex vivo model of endotoxin tolerance: Roles of IL-10 and IFNγ. PLoS One 2014; 9:e100909 + + + Friggeri A, Cazalis M-A, Pachot A, et al.: Decreased CX3CR1 messenger RNA expression is an independent molecular biomarker of early and late mortality in critically ill patients. Critical Care 2016; 20:204 + + + Peronnet E, Venet F, Maucort-Boulch D, et al.; MIP Rea Study Group: Association between mRNA expression of CD74 and IL10 and risk of ICU-acquired infections: A multicenter cohort study. Intensive Care Med 2017; 43:1013–1020 + + + Peronnet E, Nguyen K, Cerrato E, et al.: Evaluation of mRNA biomarkers to identify risk of hospital acquired infections in children admitted to paediatric intensive care unit. PLoS One 2016; 11:e0152388 + + + Döcke W-D, Höflich C, Davis KA, et al.: Monitoring temporary immunodepression by flow cytometric measurement of monocytic HLA-DR Expression: A multicenter standardized study. Clin Chem 2005; 51:2341–2347 + + + Cazalis M-A, Friggeri A, Cavé L, et al.: Decreased HLA-DR antigen-associated invariant chain (CD74) mRNA expression predicts mortality after septic shock. Crit Care 2013; 17:R287 + + + Shakoory B, Carcillo JA, Chatham WW, et al.: Interleukin-1 receptor blockade is associated with reduced mortality in sepsis patients with features of macrophage activation syndrome: reanalysis of a prior phase III trial. Crit Care Med 2016; 44:275–281 + + + Demaret J, Walencik A, Jacob M-C: Inter-laboratory assessment of flow cytometric monocyte HLA-DR expression in clinical samples. Cytometry Part B 2013; 84B:59–62 + + + Hamada S, Jeannet R, Gossez M, et al.: Bicentric evaluation of stabilizing sampling tubes for assessment of monocyte HLA-DR expression in clinical samples. Cytometry B Clin Cytom 2022; 102:384–389 + + + de Roquetaillade C, Dupuis C, Faivre V, et al.: Monitoring of circulating monocyte HLA-DR expression in a large cohort of intensive care patients: Relation with secondary infections. Ann Intensive Care 2022; 12:39 + + + Tremblay JA, Peron F, Kreitmann L, et al.; REALISM Study Group: A stratification strategy to predict secondary infection in critical illness-induced immune dysfunction: The REALIST score. Ann Intensive Care 2022; 12:76 + + + +
+ + + 36917599 + + 2023 + 03 + 14 + +
+ + 1758-0463 + + 2023 + + 2023 + Mar + 14 + + + Database : the journal of biological databases and curation + Database (Oxford) + + AFTM: a database of transmembrane regions in the human proteome predicted by AlphaFold. + baad008 + 10.1093/database/baad008 + + Transmembrane proteins (TMPs), with diverse cellular functions, are difficult targets for structural determination. Predictions of TMPs and the locations of transmembrane segments using computational methods could be unreliable due to the potential for false positives and false negatives and show inconsistencies across different programs. Recent advances in protein structure prediction methods have made it possible to identify TMPs and their membrane-spanning regions using high-quality structural models. We developed the AlphaFold Transmembrane proteins (AFTM) database of candidate human TMPs by identifying transmembrane regions in AlphaFold structural models of human proteins and their domains using the positioning of proteins in membranes, version 3 program, followed by automatic corrections inspired by manual analysis of the results. We compared our results to annotations from the UniProt database and the Human Transmembrane Proteome (HTP) database. While AFTM did not identify transmembrane regions in some single-pass TMPs, it identified more transmembrane regions for multipass TMPs than UniProt and HTP. AFTM also showed more consistent results with experimental structures, as benchmarked against the Protein Data Bank Transmembrane proteins (PDBTM) database. In addition, some proteins previously annotated as TMPs were suggested to be non-TMPs by AFTM. We report the results of AFTM together with those of UniProt, HTP, TmAlphaFold, PDBTM and Membranome in the online AFTM database compiled as a comprehensive resource of candidate human TMPs with structural models. Database URL http://conglab.swmed.edu/AFTM. + © The Author(s) 2023. Published by Oxford University Press. + + + + Pei + Jimin + J + 0000-0002-3505-9665 + + Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, 6001 Forest Park Rd, Dallas, TX 75390, USA. + + + Department of Biophysics, University of Texas Southwestern Medical Center, 6001 Forest Park Rd, Dallas, TX 75390, USA. + + + Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, 6001 Forest Park Rd., Dallas, TX 75390, USA. + + + + Cong + Qian + Q + + Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, 6001 Forest Park Rd, Dallas, TX 75390, USA. + + + Department of Biophysics, University of Texas Southwestern Medical Center, 6001 Forest Park Rd, Dallas, TX 75390, USA. + + + Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, 6001 Forest Park Rd., Dallas, TX 75390, USA. + + + + eng + + + I-2095-20220331 + Welch Foundation + + + + + Journal Article + +
+ + England + Database (Oxford) + 101517697 + 1758-0463 + + IM +
+ + + + 2022 + 08 + 02 + + + 2023 + 01 + 31 + + + 2023 + 02 + 10 + + + 2023 + 3 + 14 + 13 + 34 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + ppublish + + 36917599 + 7077442 + 10.1093/database/baad008 + + +
+ + + 36917600 + + 2023 + 03 + 14 + +
+ + 1553-7374 + + 19 + 3 + + 2023 + Mar + 14 + + + PLoS pathogens + PLoS Pathog + + A new family of glutamate-gated chloride channels in parasitic sea louse Caligus rogercresseyi: A subunit refractory to activation by ivermectin is dominant in heteromeric assemblies. + + e1011188 + + 10.1371/journal.ppat.1011188 + + Sea louse ectoparasitosis is a major threat to fish aquaculture. Avermectins such as ivermectin and emamectin have been effectively used against sea louse infestation, but the emergence of resistance has limited their use. A better understanding of the molecular targets of avermectins is essential to the development of novel treatment strategies or new, more effective drugs. Avermectins are known to act by inhibiting neurotransmission through allosteric activation of glutamate-gated chloride channels (GluCls). We have investigated the GluCl subunit present in Caligus rogercresseyi, a sea louse affecting aquaculture in the Southern hemisphere. We identify four new subunits, CrGluCl-B to CrGluCl-E, and characterise them functionally. CrGluCl-A (previously reported as CrGluClα), CrGluCl-B and CrGluCl-C all function as glutamate channel receptors with different sensitivities to the agonist, but in contrast to subunit -A and -C, CrGluCl-B is not activated by ivermectin but is rather antagonised by the drug. CrGluCl-D channel appears active in the absence of any stimulation by glutamate or ivermectin and CrGluCl-E does not exhibit any activity. Notably, the expression of CrGluCl-B with either -A or -C subunits gives rise to receptors unresponsive to ivermectin and showing altered response to glutamate, suggesting that coexpression has led to the preferential formation of heteromers to which the presence of CrGluCl-B confers the property of ivermectin-activation refractoriness. Furthermore, there was evidence for heteromer formation with novel properties only when coexpressing pairs E/C and D/B CrGluCl subtypes. Site-directed mutagenesis shows that three transmembrane domain residues contribute to the lack of activation by ivermectin, most crucially Gln 15' in M2, with mutation Q15'T (the residue present in ivermectin-activated subunits A and C) conferring ivermectin activation to CrGluCl-B. The differential response to avermectin of these Caligus rogercresseyi GluClsubunits, which are highly conserved in the Northern hemisphere sea louse Lepeophtheirus salmonis, could have an influence on the response of these parasites to treatment with macrocyclic lactones. They could serve as molecular markers to assess susceptibility to existing treatments and might be useful molecular targets in the search for novel antiparasitic drugs. + Copyright: © 2023 Tribiños et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Tribiños + Felipe + F + + Centro de Estudios Científicos (CECs), Valdivia, Chile. + + + + Cuevas + Patricio + P + + Centro de Estudios Científicos (CECs), Valdivia, Chile. + + + + Cornejo + Isabel + I + + Centro de Estudios Científicos (CECs), Valdivia, Chile. + + + Facultad de Ciencias para el Cuidado de la Salud, Universidad San Sebastián, Valdivia, Chile. + + + + Sepúlveda + Francisco V + FV + https://orcid.org/0000-0003-0022-6598 + + Centro de Estudios Científicos (CECs), Valdivia, Chile. + + + Facultad de Medicina y Ciencia, Universidad San Sebastián, Valdivia, Chile. + + + + Cid + L Pablo + LP + https://orcid.org/0000-0003-0394-0498 + + Centro de Estudios Científicos (CECs), Valdivia, Chile. + + + Facultad de Medicina y Ciencia, Universidad San Sebastián, Valdivia, Chile. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + PLoS Pathog + 101238921 + 1553-7366 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 06 + 16 + + + 2023 + 02 + 07 + + + 2023 + 3 + 14 + 13 + 34 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917600 + 10.1371/journal.ppat.1011188 + PPATHOGENS-D-22-01066 + + +
+ + + 36917597 + + 2023 + 03 + 14 + +
+ + 1935-2735 + + 17 + 3 + + 2023 + Mar + + + PLoS neglected tropical diseases + PLoS Negl Trop Dis + + Impact of adverse events during community-wide mass drug administration for soil-transmitted helminths on subsequent participation-a Theory of Planned Behaviour analysis. + + e0011148 + + 10.1371/journal.pntd.0011148 + + Experiencing adverse events (AEs) during mass drug administration (MDA) could affect participation in future MDAs. This study aims to understand the potential influence of AEs during a community-wide MDA (cMDA) trial for soil-transmitted helminths (STH) in India on intention to participate in future cMDAs. + This study was conducted using a multi-method quantitative and qualitative approach among 74 participants who experienced an AE during STH cMDA and the 12 participants who subsequently refused cMDA treatment of the ongoing DeWorm3 trial. Path analysis and thematic analysis guided by the Theory of Planned Behaviour, was used. + Among 74 individuals who reported an AE, 12% refused treatment in the cMDA immediately subsequent to their AE and 4% refused in all subsequent cMDAs. Of these 74 individuals, 59 (80%) completed a survey and eight participated in in-depth interviews. A positive attitude towards deworming and perceived ability to participate in cMDA (perceived behavioural control) were significant predictors of intention to participate in cMDA (p<0.05). A positive attitude towards cMDA was associated with caste (χ2 = 3.83, P = 0.05), particularly among the scheduled caste/scheduled tribe (SC/ST) (62%). Perceived behavioural control in cMDA participation was associated with occupation (χ2 = 5.02, P<0.05), with higher perceived control among those engaged in skilled occupations (78%). Intention to participate in subsequent cMDAs was associated with caste and family type (χ2 = 3.83, P = 0.05 and χ2 = 7.50, P<0.05 respectively) and was higher among SC/ST (62%) and those with extended families (67%). In-depth interviews demonstrated that perceived severe AEs may lead to treatment refusal in future, particularly if children were affected. + Intention to participate in future STH cMDAs was associated with caste (SC/ST) and family type (extended families). Therefore, community mobilization messages about potential AEs and their management may need to intentionally target non-SC/ST households, nuclear families, and those engaged in unskilled occupations to increase cMDA participation given the possibility of AEs occurring. + NCT03014167, ClinicalTrials.gov. + Copyright: © 2023 Aruldas et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Aruldas + Kumudha + K + + The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, India. + + + + Israel + Gideon John + GJ + + The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, India. + + + + Johnson + Jabaselvi + J + + The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, India. + + + + Titus + Angelin + A + + The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, India. + + + + Saxena + Malvika + M + + The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, India. + + + + Kaliappan + Saravanakumar Puthupalayam + SP + + The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, India. + + + + Ramesh + Rohan Michael + RM + + The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, India. + + + + Walson + Judd L + JL + + Departments of Global Health, Medicine, Pediatrics and Epidemiology, University of Washington, Seattle, Washington, United States of America. + + + The DeWorm3 Project, University of Washington, Seattle, Washington, United States of America. + + + + Means + Arianna Rubin + AR + + The DeWorm3 Project, University of Washington, Seattle, Washington, United States of America. + + + Department of Global Health, University of Washington, Seattle, Washington, United States of America. + + + + Ajjampur + Sitara S R + SSR + https://orcid.org/0000-0003-3419-6577 + + The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, India. + + + + eng + + + ClinicalTrials.gov + + NCT03014167 + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + PLoS Negl Trop Dis + 101291488 + 1935-2727 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 09 + 07 + + + 2023 + 02 + 07 + + + 2023 + 3 + 14 + 13 + 34 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917597 + 10.1371/journal.pntd.0011148 + PNTD-D-22-01128 + + +
+ + + 36917598 + + 2023 + 03 + 14 + +
+ + 1932-6203 + + 18 + 3 + + 2023 + + + PloS one + PLoS One + + Design and implementation of a global site assessment survey among HIV clinics participating in the International epidemiology Databases to Evaluate AIDS (IeDEA) research consortium. + + e0268167 + + 10.1371/journal.pone.0268167 + + Timely descriptions of HIV service characteristics and their evolution over time across diverse settings are important for monitoring the scale-up of evidence-based program strategies, understanding the implementation landscape, and examining service delivery factors that influence HIV care outcomes. + The International epidemiology Databases to Evaluate AIDS (IeDEA) consortium undertakes periodic cross-sectional surveys on service availability and care at participating HIV treatment sites to characterize trends and inform the scientific agenda for HIV care and implementation science communities. IeDEA's 2020 general site assessment survey was developed through a consultative, 18-month process that engaged diverse researchers in identifying content from previous surveys that should be retained for longitudinal analyses and in developing expanded and new content to address gaps in the literature. An iterative review process was undertaken to standardize the format of new survey questions and align them with best practices in survey design and measurement and lessons learned through prior IeDEA site assessment surveys. + The survey questionnaire developed through this process included eight content domains covered in prior surveys (patient population, staffing and community linkages, HIV testing and diagnosis, new patient care, treatment monitoring and retention, routine HIV care and screening, pharmacy, record-keeping and patient tracing), along with expanded content related to antiretroviral therapy (differentiated service delivery and roll-out of dolutegravir-based regimens); mental health and substance use disorders; care for pregnant/postpartum women and HIV-exposed infants; tuberculosis preventive therapy; and pediatric/adolescent tuberculosis care; and new content related to Kaposi's sarcoma diagnostics, the impact of COVID-19 on service delivery, and structural barriers to HIV care. The survey was distributed to 238 HIV treatment sites in late 2020, with a 95% response rate. + IeDEA's approach for site survey development has broad relevance for HIV research networks and other priority health conditions. + Copyright: © 2023 Brazier et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Brazier + Ellen + E + https://orcid.org/0000-0002-8514-1958 + + City University of New York, Institute for Implementation Science in Population Health, New York, NY, United States of America. + + + City University of New York, Graduate School of Public Health and Health Policy, New York, NY, United States of America. + + + + Maruri + Fernanda + F + + Department of Medicine, Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, United States of America. + + + + Wester + C William + CW + + Department of Medicine, Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, United States of America. + + + Vanderbilt Institute for Global Health, Nashville, TN, United States of America. + + + + Musick + Beverly + B + https://orcid.org/0000-0003-0334-6798 + + School of Medicine, Indiana University, Indianapolis, IN, United States of America. + + + + Freeman + Aimee + A + + Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America. + + + + Parcesepe + Angela + A + + Department of Maternal and Child Health, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America. + + + + Hossmann + Stefanie + S + + Institute of Social and Preventive Medicine, University of Berne, Berne, Switzerland. + + + + Christ + Benedikt + B + + Institute of Social and Preventive Medicine, University of Berne, Berne, Switzerland. + + + + Kimmel + April + A + + Department of Health Behavior and Policy, Virginia Commonwealth University School of Medicine/VCU Health, Richmond, VA, United States of America. + + + + Humphrey + John + J + + Division of Infectious Diseases, Department of Medicine, Indiana University, Indianapolis, IN, United States of America. + + + + Freeman + Esther + E + + Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States of America. + + + + Enane + Leslie A + LA + + The Ryan White Center for Pediatric Infectious Disease and Global Health, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, United States of America. + + + + Lancaster + Kathryn E + KE + + Division of Epidemiology, College of Public Health, The Ohio State University, Columbus, OH, United States of America. + + + + Ballif + Marie + M + + Institute of Social and Preventive Medicine, University of Berne, Berne, Switzerland. + + + + Golub + Jonathan E + JE + + Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America. + + + + Nash + Denis + D + + City University of New York, Institute for Implementation Science in Population Health, New York, NY, United States of America. + + + City University of New York, Graduate School of Public Health and Health Policy, New York, NY, United States of America. + + + + Duda + Stephany N + SN + + Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, United States of America. + + + + International epidemiology Databases to Evaluate AIDS (IeDEA) consortium + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2022 + 04 + 22 + + + 2023 + 02 + 28 + + + 2023 + 3 + 14 + 13 + 34 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917598 + 10.1371/journal.pone.0268167 + PONE-D-22-11895 + + +
+ + + 36917607 + + 2023 + 03 + 14 + +
+ + 2666-1667 + + 4 + 2 + + 2023 + Mar + 13 + + + STAR protocols + STAR Protoc + + Protocol to engineer apical-out airway organoids using suspension culture of human airway basal stem cell aggregates. + + 102154 + + S2666-1667(23)00112-0 + 10.1016/j.xpro.2023.102154 + + Here we present a protocol to engineer apical-out airway organoids (AOAOs) directly from human airway basal stem cells (hABSCs) using suspension culture of hABSC aggregates on a cell-repellent surface. We describe steps to produce spherical AOAOs with homogenous presentation of exterior-facing motile cilia and of tunable sizes. We then detail procedures to analyze AOAO cellular composition via wholemount staining and assess cilia motility via 3D AOAO rotation upon Matrigel embedding. The protocol offers an effective model for investigating human airway pathophysiology. For complete details on the use and execution of this protocol, please refer to Wijesekara et al. (2022).1. + Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved. + + + + Wijesekara + Piyumi + P + + Department of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA. + + + + Patel + Kian Z + KZ + + Department of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA. + + + + Otto + Ellen L + EL + + Department of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA. + + + + Campbell + Phil G + PG + + Department of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA. + + + + Ren + Xi + X + + Department of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA. Electronic address: xiren@cmu.edu. + + + + eng + + Journal Article + + + 2023 + 03 + 13 + +
+ + United States + STAR Protoc + 101769501 + 2666-1667 + + IM + + Biotechnology and Bioengineering + Cell Differentiation + Organoids + Stem Cells + + Declaration of interests A patent has been filed by Carnegie Mellon University on the technology described in this protocol. +
+ + + + 2022 + 11 + 29 + + + 2023 + 01 + 09 + + + 2023 + 02 + 13 + + + 2023 + 3 + 14 + 13 + 36 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917607 + S2666-1667(23)00112-0 + 10.1016/j.xpro.2023.102154 + + +
+ + + 36917608 + + 2023 + 03 + 14 + +
+ + 2666-1667 + + 4 + 2 + + 2023 + Mar + 13 + + + STAR protocols + STAR Protoc + + Protocol to establish a genetically tractable synthetic symbiosis between Sodalis praecaptivus and grain weevils by insect egg microinjection. + + 102156 + + S2666-1667(23)00114-4 + 10.1016/j.xpro.2023.102156 + + We present a protocol to establish a synthetic symbiosis between the mCherry-expressing Sodalis praecaptivus and the grain weevil host, Sitophilus zeamais. We describe steps to isolate grain weevil eggs, followed by microinjecting the bacterial symbiont into insect eggs using a modified Drosophila injection protocol, which leads to localization of bacteria in female insect ovaries. We then detail larval transplantation and visualization of bacteria in live insects using a fluorescence dissection microscope to assess the transgenerational transmission to offspring in weevils. For complete details on the use and execution of this protocol, please refer to Su et al. (2022).1. + Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved. + + + + Su + Yinghua + Y + + School of Biological Sciences, University of Utah, Salt Lake City, UT 84112, USA. + + + + Lin + Ho-Chen + HC + + School of Biological Sciences, University of Utah, Salt Lake City, UT 84112, USA. + + + + Dale + Colin + C + + School of Biological Sciences, University of Utah, Salt Lake City, UT 84112, USA. Electronic address: colin.dale@utah.edu. + + + + eng + + Journal Article + + + 2023 + 03 + 13 + +
+ + United States + STAR Protoc + 101769501 + 2666-1667 + + IM + + Evolutionary Biology + Microbiology + Model Organisms + + Declaration of interests The authors declare no competing interests. +
+ + + + 2022 + 09 + 21 + + + 2022 + 12 + 21 + + + 2023 + 02 + 10 + + + 2023 + 3 + 14 + 13 + 36 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917608 + S2666-1667(23)00114-4 + 10.1016/j.xpro.2023.102156 + + +
+ + + 36917609 + + 2023 + 03 + 14 + +
+ + 2211-1247 + + 42 + 3 + + 2023 + Mar + 13 + + + Cell reports + Cell Rep + + Triap1 upregulation promotes escape from mitotic-slippage-induced G1 arrest. + + 112215 + + S2211-1247(23)00226-7 + 10.1016/j.celrep.2023.112215 + + Drugs targeting microtubules rely on the mitotic checkpoint to arrest cell proliferation. The prolonged mitotic arrest induced by such drugs is followed by a G1 arrest. Here, we follow for several weeks the fate of G1-arrested human cells after treatment with nocodazole. We find that a small fraction of cells escapes from the arrest and resumes proliferation. These escaping cells experience reduced DNA damage and p21 activation. Cells surviving treatment are enriched for anti-apoptotic proteins, including Triap1. Increasing Triap1 levels allows cells to survive the first treatment with reduced DNA damage and lower levels of p21; accordingly, decreasing Triap1 re-sensitizes cells to nocodazole. We show that Triap1 upregulation leads to the retention of cytochrome c in the mitochondria, opposing the partial activation of caspases caused by nocodazole. In summary, our results point to a potential role of Triap1 upregulation in the emergence of resistance to drugs that induce prolonged mitotic arrest. + Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved. + + + + Pavani + Mattia + M + + IFOM ETS - The AIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milano, Italy. Electronic address: mattia.pavani@ifom.eu. + + + + Chiroli + Elena + E + + IFOM ETS - The AIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milano, Italy. + + + + Cancrini + Camilla + C + + IFOM ETS - The AIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milano, Italy. + + + + Gross + Fridolin + F + + ImmunoConcEpT, CNRS UMR5164, Université de Bordeaux, 33076 Bordeaux, France. + + + + Bonaiuti + Paolo + P + + IFOM ETS - The AIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milano, Italy. + + + + Villa + Stefano + S + + Dipartimento di Biotecnologie Mediche e Medicina Traslazionale, Universitá degli Studi di Milano, 20090 Segrate, Italy. + + + + Giavazzi + Fabio + F + + Dipartimento di Biotecnologie Mediche e Medicina Traslazionale, Universitá degli Studi di Milano, 20090 Segrate, Italy. + + + + Matafora + Vittoria + V + + IFOM ETS - The AIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milano, Italy. + + + + Bachi + Angela + A + + IFOM ETS - The AIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milano, Italy. + + + + Fava + Luca L + LL + + Armenise-Harvard Laboratory of Cell Division, Department of Cellular, Computational and Integrative Biology - CIBIO, University of Trento, Trento, Italy. + + + + Lischetti + Tiziana + T + + IFOM ETS - The AIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milano, Italy. Electronic address: tiziana.lischetti@icloud.com. + + + + Ciliberto + Andrea + A + + IFOM ETS - The AIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milano, Italy; Pázmány Péter Catholic University, Faculty of Information Technology and Bionics, 1083 Budapest, Hungary. Electronic address: andrea.ciliberto@ifom.eu. + + + + eng + + Journal Article + + + 2023 + 03 + 13 + +
+ + United States + Cell Rep + 101573691 + + IM + + CP: Cell biology + CP: Molecular biology + cell cycle + microtubule targeting drugs + mitosis + sublethal caspase activation + + Declaration of interests The authors declare no competing interests. +
+ + + + 2022 + 08 + 09 + + + 2023 + 01 + 13 + + + 2023 + 02 + 17 + + + 2023 + 3 + 14 + 13 + 36 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917609 + S2211-1247(23)00226-7 + 10.1016/j.celrep.2023.112215 + + +
+ + + 36917604 + + 2023 + 03 + 14 + +
+ + 2666-1667 + + 4 + 2 + + 2023 + Mar + 13 + + + STAR protocols + STAR Protoc + + Protocol for in vitro phosphorylation of the MUS81-binding region of SLX4 using CDK1-cyclin B. + + 102152 + + S2666-1667(23)00110-7 + 10.1016/j.xpro.2023.102152 + + Phosphorylation is a post-translational modification that can alter protein structure and regulate protein-protein interactions. Here, we present a procedure for in vitro phosphorylation of the MUS81-binding region of SLX4 (SLX4MBR) using cyclin-dependent kinase 1-cyclin B. We describe steps for the dialysis and phosphorylation of target proteins followed by purification using size-exclusion chromatography. Finally, we detail a system to monitor phosphorylation effectiveness and identify phosphorylated residues. We anticipate this protocol to be readily adapted for other protein targets or kinases. For complete details on the use and execution of this protocol, please refer to Payliss et al. (2022).1. + Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved. + + + + Payliss + Brandon J + BJ + + Department of Biochemistry, University of Toronto, Toronto, ON M56 1A8, Canada. Electronic address: brandon.payliss@mail.utoronto.ca. + + + + Wyatt + Haley D M + HDM + + Department of Biochemistry, University of Toronto, Toronto, ON M56 1A8, Canada; Canada Research Chairs Program, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address: haley.wyatt@utoronto.ca. + + + + eng + + Journal Article + + + 2023 + 03 + 13 + +
+ + United States + STAR Protoc + 101769501 + 2666-1667 + + IM + + Molecular Biology + Protein Biochemistry + + Declaration of interests The authors declare no competing interests. +
+ + + + 2022 + 12 + 23 + + + 2023 + 01 + 23 + + + 2023 + 02 + 13 + + + 2023 + 3 + 14 + 13 + 36 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917604 + S2666-1667(23)00110-7 + 10.1016/j.xpro.2023.102152 + + +
+ + + 36917601 + + 2023 + 03 + 14 + +
+ + 1932-6203 + + 18 + 3 + + 2023 + + + PloS one + PLoS One + + Predicting soft tissue thicknesses overlying the iliac crests and greater trochanters of younger and older adults. + + e0283012 + + 10.1371/journal.pone.0283012 + + Soft tissues overlying the hip play a critical role in protecting against fractures during fall-related hip impacts. Consequently, the development of an efficient and cost-effective method for estimating hip soft tissue thicknesses in living people may prove to be valuable for assessing an individual's injury risk and need to adopt preventative measures. The present study used multiple linear stepwise regression to generate prediction equations from participant characteristics (i.e., height, sex) and anthropometric measurements of the pelvis, trunk, and thigh to estimate soft tissue thickness at the iliac crests (IC) and greater trochanters (GT) in younger (16-35 years of age: 37 males, 37 females) and older (36-65 years of age: 38 males, 38 females) adults. Equations were validated against soft tissue thicknesses measured from full body Dual-energy X-ray Absorptiometry scans of independent samples (younger: 13 males, 13 females; older: 13 males, 12 females). Younger adult prediction equations exhibited adjusted R2 values ranging from 0.704 to 0.791, with more explained variance for soft tissue thicknesses at the GT than the IC; corresponding values for the older adult equations were higher overall and ranged from 0.819 to 0.852. Predicted and actual soft tissue thicknesses were significantly correlated for both the younger (R2 = 0.466 to 0.738) and older (R2 = 0.842 to 0.848) adults, averaging ≤ 0.75cm of error. This research demonstrates that soft tissue thicknesses overlying the GT and IC can be accurately predicted from equations using anthropometric measurements. These equations can be used by clinicians to identify individuals at higher risk of hip fractures who may benefit from the use of preventative measures. + Copyright: © 2023 Town et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Town + Claudia M + CM + https://orcid.org/0000-0002-7699-3198 + + Department of Kinesiology, University of Windsor, Windsor, Ontario, Canada. + + + + Gyemi + Danielle L + DL + + Department of Kinesiology, University of Windsor, Windsor, Ontario, Canada. + + + + Ellis + Zoe + Z + + Department of Kinesiology, University of Windsor, Windsor, Ontario, Canada. + + + + Kahelin + Charles + C + + Department of Kinesiology, University of Windsor, Windsor, Ontario, Canada. + + + + Laing + Andrew C + AC + + Department of Kinesiology, University of Windsor, Windsor, Ontario, Canada. + + + + Andrews + David M + DM + + Department of Kinesiology, University of Windsor, Windsor, Ontario, Canada. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared that no competing interests exist. +
+ + + + 2023 + 01 + 03 + + + 2023 + 02 + 28 + + + 2023 + 3 + 14 + 13 + 34 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917601 + 10.1371/journal.pone.0283012 + PONE-D-23-00184 + + +
+ + + 36917613 + + 2023 + 03 + 14 + +
+ + 1943-569X + + + 2023 + Mar + 18 + + + Journal of the American Veterinary Medical Association + J Am Vet Med Assoc + + Food allergy in dogs and cats; current perspectives on aetiology, diagnosis, and management. + + 1-7 + + 10.2460/javma.22.12.0548 + + Food allergy is a recognized clinical entity in dogs and cats and is an important differential to consider in the workup of a pruritic animal. Food can be a trigger factor for canine atopic dermatitis, and food allergy may coexist with feline atopic skin syndrome. Other clinical signs such as urticaria, recurrent pyoderma, and dorsolumbar pruritus can be seen in dogs, and urticaria, conjunctivitis, and respiratory signs can be seen in cats. In both species, gastrointestinal signs may be present. The pathogenesis in dogs and cats is complex and incompletely understood, which limits the development of reliable diagnostic laboratory tests. The diagnosis currently relies on an appropriately performed diet trial with subsequent provocation. This paper briefly reviews food allergies in people and explores our current knowledge of the disorder in dogs and cats. + + + + Jackson + Hilary A + HA + + + eng + + Journal Article + + + 2023 + 03 + 18 + +
+ + United States + J Am Vet Med Assoc + 7503067 + 0003-1488 + + IM +
+ + + + 2022 + 12 + 12 + + + 2023 + 02 + 15 + + + 2023 + 3 + 14 + 13 + 43 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917613 + 10.2460/javma.22.12.0548 + + +
+ + + 36917602 + + 2023 + 03 + 14 + +
+ + 1932-6203 + + 18 + 3 + + 2023 + + + PloS one + PLoS One + + Climate change alters slug abundance but not herbivory in a temperate grassland. + + e0283128 + + 10.1371/journal.pone.0283128 + + Climate change will significantly impact the world's ecosystems, in part by altering species interactions and ecological processes, such as herbivory and plant community dynamics, which may impact forage quality and ecosystem production. Yet relatively few field experimental manipulations assessing all of these parameters have been performed to date. To help fill this knowledge gap, we evaluated the effects of increased temperature (+3°C day and night, year-round) and precipitation (+30% of mean annual rainfall) on slug herbivory and abundance and plant community dynamics biweekly in a pasture located in central Kentucky, U.S.A. Warming increased slug abundance once during the winter, likely due to improving conditions for foraging, whereas warming reduced slug abundance at times in late spring, mid-summer, and early fall (from 62-95% reduction depending on month). We found that warming and increased precipitation did not significantly modify slug herbivory at our site, despite altering slug abundance and affecting plant community composition and forage quality. Climate change will alter seasonal patterns of slug abundance through both direct effects on slug biology and indirect effects mediated by changes in the plant community, suggesting that pasture management practices may have to adapt. + Copyright: © 2023 Weber et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. + + + + Weber + Daniel + D + + Department of Plant & Soil Sciences, University of Kentucky, Lexington, KY, United States of America. + + + + McGrail + Rebecca K + RK + https://orcid.org/0000-0001-7775-1564 + + Department of Plant & Soil Sciences, University of Kentucky, Lexington, KY, United States of America. + + + + Carlisle + A Elizabeth + AE + + Department of Plant & Soil Sciences, University of Kentucky, Lexington, KY, United States of America. + + + + Harwood + James D + JD + + Department of Entomology, University of Kentucky, Lexington, KY, United States of America. + + + + McCulley + Rebecca L + RL + + Department of Plant & Soil Sciences, University of Kentucky, Lexington, KY, United States of America. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + PLoS One + 101285081 + 1932-6203 + + IM + The authors have declared no competing interests exist. +
+ + + + 2022 + 09 + 06 + + + 2023 + 03 + 03 + + + 2023 + 3 + 14 + 13 + 34 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + epublish + + 36917602 + 10.1371/journal.pone.0283128 + PONE-D-22-24545 + + +
+ + + 36917603 + + 2023 + 03 + 14 + +
+ + 2666-1667 + + 4 + 2 + + 2023 + Mar + 13 + + + STAR protocols + STAR Protoc + + Isolation, culture, and use of primary murine myoblasts in small-molecule screens. + + 102149 + + S2666-1667(23)00107-7 + 10.1016/j.xpro.2023.102149 + + Small-molecule screens (SMS) are often performed using transformed cell lines that have limited physiological relevance to the biological system being investigated, resulting in poor translational outcomes. To circumvent this limitation, we present a protocol to perform SMS in primary murine myoblasts. We describe steps for isolating primary skeletal muscle myoblasts with greater than 95% purity, then describe techniques to establish a robust dynamic range, and conclude with steps to initiate a successful SMS. For complete details on the use and execution of this protocol, please refer to Richler and Yaffe (1970),1 Rando and Blau (1994),2 and Earle et al. (2020).3. + Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved. + + + + Qu + Yue + Y + + Division of Nutritional Sciences, Cornell University, Ithaca, NY 14850, USA. + + + + Edwards + Kaydine + K + + Division of Nutritional Sciences, Cornell University, Ithaca, NY 14850, USA. + + + + Barrow + Joeva + J + + Division of Nutritional Sciences, Cornell University, Ithaca, NY 14850, USA. Electronic address: jb2254@cornell.edu. + + + + eng + + Journal Article + + + 2023 + 03 + 13 + +
+ + United States + STAR Protoc + 101769501 + 2666-1667 + + IM + + Cell Biology + Cell Culture + Cell Isolation + Cell-based Assays + High-throughput Screening + Metabolism + + Declaration of interests The authors declare no competing interests. +
+ + + + 2022 + 11 + 23 + + + 2023 + 01 + 04 + + + 2023 + 02 + 10 + + + 2023 + 3 + 14 + 13 + 36 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917603 + S2666-1667(23)00107-7 + 10.1016/j.xpro.2023.102149 + + +
+ + + 36917610 + + 2023 + 03 + 14 + +
+ + 2211-1247 + + 42 + 3 + + 2023 + Mar + 13 + + + Cell reports + Cell Rep + + The tetraspan LHFPL5 is critical to establish maximal force sensitivity of the mechanotransduction channel of cochlear hair cells. + + 112245 + + S2211-1247(23)00256-5 + 10.1016/j.celrep.2023.112245 + + The mechanoelectrical transduction (MET) channel of cochlear hair cells is gated by the tip link, but the mechanisms that establish the exquisite force sensitivity of this MET channel are not known. Here, we show that the tetraspan lipoma HMGIC fusion partner-like 5 (LHFPL5) directly couples the tip link to the MET channel. Disruption of these interactions severely perturbs MET. Notably, the N-terminal cytoplasmic domain of LHFPL5 binds to an amphipathic helix in TMC1, a critical gating domain conserved between different MET channels. Mutations in the amphipathic helix of TMC1 or in the N-terminus of LHFPL5 that perturb interactions of LHFPL5 with the amphipathic helix affect channel responses to mechanical force. We conclude that LHFPL5 couples the tip link to the MET channel and that channel gating depends on a structural element in TMC1 that is evolutionarily conserved between MET channels. Overall, our findings support a tether model for transduction channel gating by the tip link. + Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved. + + + + Qiu + Xufeng + X + + The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. + + + + Liang + Xiaoping + X + + The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. + + + + Llongueras + Jose P + JP + + The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. + + + + Cunningham + Christopher + C + + Pittsburgh Hearing Research Center, Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA 15213, USA. + + + + Müller + Ulrich + U + + The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: umuelle3@jhmi.edu. + + + + eng + + Journal Article + + + 2023 + 03 + 13 + +
+ + United States + Cell Rep + 101573691 + + IM + + CP: Neuroscience + LHFPL5 + TMC1 + TMIE + deafness + hair cell + hearing + mechanotransduction + tethered channel + tip link + + Declaration of interests U.M. is a co-founder of Decibel Therapeutics. +
+ + + + 2022 + 11 + 16 + + + 2023 + 01 + 28 + + + 2023 + 02 + 27 + + + 2023 + 3 + 14 + 13 + 36 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917610 + S2211-1247(23)00256-5 + 10.1016/j.celrep.2023.112245 + + +
+ + + 36917606 + + 2023 + 03 + 14 + +
+ + 2666-1667 + + 4 + 2 + + 2023 + Mar + 13 + + + STAR protocols + STAR Protoc + + Protocol for genome-scale in vivo CRISPR screening to study protection of beta cells under autoimmunity in a type 1 diabetes mouse model. + + 102155 + + S2666-1667(23)00113-2 + 10.1016/j.xpro.2023.102155 + + Autoimmunity-induced pancreatic beta cell failure is the main characteristic of type 1 diabetes (T1D). Here, we describe a protocol for genome-scale in vivo CRISPR-Cas9 screening for use in a mouse model of T1D. Using a non-obese-diabetic-derived mouse beta cell line, NIT-1, and a genome-wide CRISPR-Cas9 knockout library (GeCKO-v2), we describe how to identify genes that confer resistance to autoimmune killing. This protocol can be applied in other mouse models of autoimmunity. For complete details on the use and execution of this protocol, please refer to Cai et al. (2020).1. + Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved. + + + + Li + Jian + J + + Section for Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA. + + + + Lee + Yu-Chi + YC + + Section for Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA. + + + + Iessi + Isabela L + IL + + Lilly Diabetes Center of Excellence, Indiana Biosciences Research Institute, Indianapolis, IN 46202, USA. + + + + Wu + Chialing + C + + Lilly Diabetes Center of Excellence, Indiana Biosciences Research Institute, Indianapolis, IN 46202, USA. + + + + Yi + Peng + P + + Section for Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address: peng.yi@joslin.harvard.edu. + + + + Cai + Erica P + EP + + Lilly Diabetes Center of Excellence, Indiana Biosciences Research Institute, Indianapolis, IN 46202, USA; Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA. Electronic address: ecai@indianabiosciences.org. + + + + eng + + Journal Article + + + 2023 + 03 + 13 + +
+ + United States + STAR Protoc + 101769501 + 2666-1667 + + IM + + CRISPR + Immunology + Metabolism + Sequencing + + Declaration of interests The authors declare no competing interests. +
+ + + + 2022 + 10 + 30 + + + 2023 + 01 + 02 + + + 2023 + 02 + 13 + + + 2023 + 3 + 14 + 13 + 36 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917606 + S2666-1667(23)00113-2 + 10.1016/j.xpro.2023.102155 + + +
+ + + 36917605 + + 2023 + 03 + 14 + +
+ + 2666-1667 + + 4 + 2 + + 2023 + Mar + 13 + + + STAR protocols + STAR Protoc + + Protocol for analyzing root halotropism using split-agar system in Arabidopsis thaliana. + + 102157 + + S2666-1667(23)00115-6 + 10.1016/j.xpro.2023.102157 + + Plant roots sense salt gradients in soil to avoid saline environments through halotropism. Here, we present a protocol to study halotropism with an optimized split-agar system that simulates the salt gradient in soil. We describe steps for preparation of the split-agar system, measurement of Na+, and observation of root bending. We then detail segmentation of root cells and visualization of microtubules and cellulose synthases. This system is simple to operate and has broader applications, such as hydrotropism and chemotropism. For complete details on the use and execution of this protocol, please refer to Yu et al. (2022).1. + Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved. + + + + Yu + Bo + B + + Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai 200032, China. + + + + Zheng + Wenna + W + + Department of Plant & Environmental Sciences, University of Copenhagen, 1871 Frederiksberg C, Denmark. + + + + Persson + Staffan + S + + Department of Plant & Environmental Sciences, University of Copenhagen, 1871 Frederiksberg C, Denmark; Copenhagen Plant Science Center, University of Copenhagen, 1871 Frederiksberg C, Denmark; Joint International Research Laboratory of Metabolic & Developmental Sciences, State Key Laboratory of Hybrid Rice, SJTU-University of Adelaide Joint Centre for Agriculture and Health, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China. + + + + Zhao + Yang + Y + + Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai 200032, China. Electronic address: yangzhao@psc.ac.cn. + + + + eng + + Journal Article + + + 2023 + 03 + 13 + +
+ + United States + STAR Protoc + 101769501 + 2666-1667 + + IM + + Cell Biology + Microscopy + Model Organisms + Molecular Biology + Plant Sciences + + Declaration of interests The authors declare no competing interests. +
+ + + + 2023 + 01 + 11 + + + 2023 + 02 + 03 + + + 2023 + 02 + 14 + + + 2023 + 3 + 14 + 13 + 36 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917605 + S2666-1667(23)00115-6 + 10.1016/j.xpro.2023.102157 + + +
+ + + 36917612 + + 2023 + 03 + 14 + +
+ + 0748-321X + + + 2023 + Mar + 13 + + + Journal of veterinary medical education + J Vet Med Educ + + Training Veterinary Ophthalmology Residents on Cataract Surgery (Part A: Diplomate's Survey). + + e20220081 + + 10.3138/jvme-2022-0081 + + The purpose of this study was to explore the teaching methods used to train residents in cataract surgery at academic and private practice institutions. A descriptive survey was distributed online to 186 active supervising diplomates of the American Board of Veterinary Ophthalmologists (ABVO) listserve. The survey included items about various educational resources and techniques available to ophthalmology residents when performing cataract surgery. Thirty-seven (19.9%) supervising diplomates completed the survey. Most supervising diplomates (29, 78.4%) required supervised practice in the wet lab. Fourteen supervising diplomates (37.8%) provided mandatory cataract surgery lectures. Nine diplomates (24.3%) required their residents to attend a formal phacoemulsification wet lab course. There was no difference in the number of diplomates who allowed their residents to perform cataract surgery as the primary surgeon during their second year compared to any other year. Thirty-three surveyed diplomates supported the idea of creating an assessment tool to improve surgical competency. This article describes the current trends in veterinary ophthalmology residency education and provides support for the creation of an assessment tool to improve surgical competency. The goal is to stimulate future research on how educators can effectively train veterinary ophthalmology residents to improve surgical proficiency. + + + + Knight + LaTisha N + LN + 0000-0003-0153-4170 + + Comparative Ophthalmology, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607 USA. + + + + Royal + Kenneth + K + 0000-0002-5508-1480 + + Office of Academic Affairs, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061 USA. + + + + eng + + Journal Article + + + 2023 + 03 + 13 + +
+ + Canada + J Vet Med Educ + 7610519 + 0748-321X + + IM + + cataract surgery + ophthalmology + phacoemulsification + residents + training + veterinary education + +
+ + + + 2023 + 3 + 14 + 13 + 42 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917612 + 10.3138/jvme-2022-0081 + + +
+ + + 36917619 + + 2023 + 03 + 14 + +
+ + 2054-1058 + + + 2023 + Mar + 14 + + + Nursing open + Nurs Open + + Evaluation of an Education Program on Community Orientation among Community Health Nurses in Fiji. + 10.1002/nop2.1712 + + The study objective was to evaluate the effectiveness of an education program to improve community orientation among community health nurses in Fiji. A 1.5-day education program was developed that enabled participants to learn a concept through discussion, as they reviewed their experiences. + This study used mixed methods research. + The education program involving 78 community health nurses and supervisors was conducted. The 30-item Community Orientation among Community Health Nurses scale, six-item program evaluation questionnaire, and participant reflection sheets were analyzed using both quantitative and qualitative methods. + Program evaluations demonstrated high satisfaction among participants. The content analysis of participant views on community orientation revealed three categories; utilizing community intelligence in community activities, relationships with community members as a community health nurses, and human resource development tool. Our findings suggest that this education program should be held regularly, in conjunction with on-the-job and off-site training. + © 2023 The Authors. Nursing Open published by John Wiley & Sons Ltd. + + + + Tanabe + Sachiko + S + https://orcid.org/0000-0002-7379-680X + + Kitasato University School of Nursing, Sagamihara, Japan. + + + + Hirano + Kayoko + K + + Miyazaki Prefectural Nursing University, Miyazaki, Japan. + + + + Yanagisawa + Satoko + S + + Aichi Prefectural University School of Nursing & Health, Nagoya, Japan. + + + + Ledua + Silina Waqa + SW + + Pacific Community Suva Regional Office, Suva, Fiji. + + + + Tukana + Mereani + M + + Former Ministry of Health Cent/East Health Services, Suva, Fiji. + + + + eng + + + JP17H07223 + Japan Society for the Promotion of Science + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Nurs Open + 101675107 + 2054-1058 + + IM + + activity management + community health activity + community health nurses + community orientation + education + +
+ + + + 2022 + 10 + 29 + + + 2021 + 10 + 14 + + + 2023 + 02 + 20 + + + 2023 + 3 + 14 + 13 + 43 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917619 + 10.1002/nop2.1712 + + + REFERENCES + + Anderson, E. T., & McFarlane, J. M. (2010). Community as partner: Theory and practice in nursing. Lippincott Williams & Wilkins. + + + Benner, P. (1982). From novice to expert. The American Journal of Nursing, 82(3), 402-407. + + + Boud, D., Cohen, R., & Sampson, J. (2013). Peer learning in higher education: Learning from & with each other (1st ed.). Routledge. https://doi.org/10.4324/9781315042565 + + + Cleary, M., Horsfall, J., O'Hara-Aarons, M., Jackson, D., & Hunt, G. E. (2011). The views of mental health nurses on continuing professional development. Journal of Clinical Nursing, 20, 3561-3566. https://doi.org/10.1111/j.1365-2702.2011.03745.x + + + Creswell, J. W. (2014). A concise Introduction to mixed methods research. SAGE. + + + Dearie, C., Linhart, C., Rafai, E., Nand, D., Morrell, S., & Taylor, R. (2021). Trends in mortality and life expectancy in Fiji over 20 years. BMC Public Health, 21(1), 1185. https://doi.org/10.1186/s12889-021-11186-w + + + Graneheim, U. H., & Lundman, B. (2004). Qualitative content analysis in nursing research: Concepts, procedures and measures to achieve trustworthiness. Nurse Education Today, 24(2), 105-112. https://doi.org/10.1016/j.nedt.2003.10.001 + + + Green, L. W., & Kreuter, M. W. (2005). Health program planning: An educational and ecological approach. McGraw-Hill Humanities. + + + Haggerty, J., Burge, F., Lévesque, J. F., Gass, D., Pineault, R., Beaulieu, M. D., & Santor, D. (2007). Operational definitions of attributes of primary health care: Consensus among Canadian experts. Annals of Family Medicine, 5(4), 336-344. https://doi.org/10.1370/afm.682 + + + Institute of Medicine Committee for the Study of the Future of Public Health. (1998). The future of the public's health in the 21st century (pp. 411-412). Institute of Medicine. https://doi.org/10.17226/1091 + + + Liimatainen, L., Poskiparta, M., Karhila, P., & Sjögren, A. (2001). The development of reflective learning in the context of health counselling and health promotion during nurse education. Journal of Advanced Nursing, 34(5), 648-658. https://doi.org/10.1046/j.1365-2648.2001.01794.x + + + Markowski, M., Bower, H., Essex, R., & Yearley, C. (2021). Peer learning and collaborative placement models in health care: A systematic review and qualitative synthesis of the literature. Journal of Clinical Nursing, 30(11-12), 1519-1541. https://doi.org/10.1111/jocn.15661 + + + Ministry of Health and Medical Services. (2015). National strategic plan 2016-2020 (pp. 3-10). https://www.health.gov.fj/wp-content/uploads/2018/03/Strategic-Plan-2016-2020-Executive-Version.pdf + + + Ministry of Health and Medical Services. (2020). Strategic Plan 2020-2025 (pp. 3-14). https://www.health.gov.fj/wp-content/uploads/2020/05/Strategic-Plan-2020-2025-1.pdf + + + Muldoon, L., Dahrouge, S., Hogg, W., Geneau, R., Russell, G., & Shortt, M. (2010). Community orientation in primary care practices: Results from the comparison of models of primary health care in Ontario study. Canadian Family Physician, 56(7), 676-683. + + + Nakamura, F., & Pike, B. (2018). Instructional design handbook. JMA Management Center Inc. Japanese. + + + O'Cathain, A., Murphy, E., & Nicholl, J. (2007). Why, and how, mixed methods research is undertaken in health services research in England: A mixed methods study. BMC Health Services Research, 7, 85. https://doi.org/10.1186/1472-6963-7-85 + + + Proenca, E. J. (1998). Community orientation in health services organizations: Concept and its implementation. Health Care Management Review, 23(2), 28-38. https://doi.org/10.1097/00004010-199804000-00004 + + + Rodrigues, C. D., & Witt, R. R. (2013). Competencies for preceptorship in the Brazilian health care system. Journal of Continuing Education in Nursing, 44(11), 507-515. https://doi.org/10.3928/00220124-20130903-63 + + + Saeki, K. (2009). Leader's perception and organization system regarding well-established OJT for public health nurses in community health: Through in-service education for beginners. Nihon Koshu Eisei Zasshi, 56(4), 242-250 Japanese. + + + Spencer, L. M., & Spencer, S. M. (1993). Competence at work: Models for superior performance (pp. 3-15). Wiley. + + + Tanabe, S., Yanagisawa, S., Waqa, S. L., & Tukana, M. (2020). Community orientation scale among community health nurses in Fiji: Scale development and psychometric evaluation. Nursing Open, 7(5), 1367-1378. https://doi.org/10.1002/nop2.508 + + + Tanabe, S., Yanagisawa, S., Waqa-Ledua, S., & Tukana, M. (2019). Identifying characteristic features of community orientation among community health nurses in Fiji. Nursing Open, 6(3), 1113-1123. https://doi.org/10.1002/nop2.305 + + + Wiseman, V., Lagarde, M., Batura, N., Lin, S., Irava, W., & Roberts, G. (2017). Measuring inequalities in the distribution of the Fiji health workforce. International Journal for Equity in Health, 16(1), 115. https://doi.org/10.1186/s12939-017-0575-1 + + + World Health Organization. Regional Office for the Western Pacific. (2011). The Fiji Islands health system review. http://iris.wpro.who.int/handle/10665.1/5534 + + + +
+ + + 36917618 + + 2023 + 03 + 14 + +
+ + 1520-6890 + + + 2023 + Mar + 14 + + + Chemical reviews + Chem Rev + + Critical Review on the Mechanisms of Fe2+ Regeneration in the Electro-Fenton Process: Fundamentals and Boosting Strategies. + 10.1021/acs.chemrev.2c00684 + + This review presents an exhaustive overview on the mechanisms of Fe3+ cathodic reduction within the context of the electro-Fenton (EF) process. Different strategies developed to improve the reduction rate are discussed, dividing them into two categories that regard the mechanistic feature that is promoted: electron transfer control and mass transport control. Boosting the Fe3+ conversion to Fe2+ via electron transfer control includes: (i) the formation of a series of active sites in both carbon- and metal-based materials and (ii) the use of other emerging strategies such as single-atom catalysis or confinement effects. Concerning the enhancement of Fe2+ regeneration by mass transport control, the main routes involve the application of magnetic fields, pulse electrolysis, interfacial Joule heating effects, and photoirradiation. Finally, challenges are singled out, and future prospects are described. This review aims to clarify the Fe3+/Fe2+ cycling process in the EF process, eventually providing essential ideas for smart design of highly effective systems for wastewater treatment and valorization at an industrial scale. + + + + Deng + Fengxia + F + + State Key Laboratory of Urban Water Resource and Environment, School of Environment, Harbin Institute of Technology, Harbin 150090, P. R. China. + + + Laboratori d'Electroquímica dels Materials i del Medi Ambient, Departament de Ciència de Materials i Química Física, Secció de Química Física, Facultat de Química, Universitat de Barcelona, Martí i Franquès 1-11, 08028 Barcelona, Spain. + + + + Olvera-Vargas + Hugo + H + + Instituto de Energías Renovables, Universidad Nacional Autónoma de México (IER-UNAM), Priv. Xochicalco S/N, Col. Centro, Temixco, Morelos CP 62580, México. + + + + Zhou + Minghua + M + + Key Laboratory of Pollution Process and Environmental Criteria, Ministry of Education, College of Environmental Science and Engineering, Nankai University, Tianjin 300350, P. R. China. + + + + Qiu + Shan + S + 0000-0001-8329-6852 + + State Key Laboratory of Urban Water Resource and Environment, School of Environment, Harbin Institute of Technology, Harbin 150090, P. R. China. + + + + Sirés + Ignasi + I + 0000-0001-5508-1774 + + Laboratori d'Electroquímica dels Materials i del Medi Ambient, Departament de Ciència de Materials i Química Física, Secció de Química Física, Facultat de Química, Universitat de Barcelona, Martí i Franquès 1-11, 08028 Barcelona, Spain. + + + + Brillas + Enric + E + + Laboratori d'Electroquímica dels Materials i del Medi Ambient, Departament de Ciència de Materials i Química Física, Secció de Química Física, Facultat de Química, Universitat de Barcelona, Martí i Franquès 1-11, 08028 Barcelona, Spain. + + + + eng + + Journal Article + Review + + + 2023 + 03 + 14 + +
+ + United States + Chem Rev + 2985134R + 0009-2665 + + IM +
+ + + + 2023 + 3 + 14 + 13 + 43 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917618 + 10.1021/acs.chemrev.2c00684 + + +
+ + + 36917617 + + 2023 + 03 + 14 + +
+ + 1936-086X + + + 2023 + Mar + 14 + + + ACS nano + ACS Nano + + Biomolecular 1D Necklace-like Nanostructures Tailoring 2D Janus Interfaces for Controllable 3D Enteric Biomaterials. + 10.1021/acsnano.2c11507 + + Construction of well-ordered two-dimensional (2D) and three-dimensional (3D) assemblies using one-dimensional (1D) units is a hallmark of many biointerfaces such as skin. Mimicking the art of difunctional properties of biointerfaces, which skin exhibits as defense and shelter materials, has inspired the development of smart and responsive biomimetic interfaces. However, programming the long-range ordering of 1D base materials toward vigorous control over 2D and 3D hierarchical structures and material properties remains a daunting challenge. In this study, we put forward construction of 3D enteric biomaterials with a two-strata 2D Janus interface assembled from self-adaptation of 1D protein-polysaccharide nanostructures at an oil-water interface. The biomaterials feature a protein dermis accommodating oil droplets as a reservoir for bioactive compounds and a polysaccharide epidermis protecting them from gastric degradation. Furthermore, the epidermis can be fine-tuned with different thicknesses rendering enteric delivery of a bioactive cargo (coumarin-6) with controllable retention in the intestinal tract from 6 to 24 h. The results highlight a skin-inspired construction of enteric biomaterials by self-adaptation of 1D nanostructures at the oil-water interface toward 2D Janus biointerfaces and 3D microdevices, which can be tailored for intestinal treatments with intentional therapeutic efficacies. + + + + Wan + Ying + Y + + Key Laboratory of Carbohydrate Chemistry and Biotechnology-Ministry of Education, Jiangnan University, Wuxi 214122, China. + + + National Engineering Research Center for Cereal Fermentation and Food Biomanufacturing, Jiangnan University, Wuxi 214122, China. + + + Jiangsu Provincial Research Centre for Bioactive Product Processing Technology, Jiangnan University, Wuxi 214122, China. + + + School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. + + + + Liu + Huilong + H + + State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Nanjing Tech University, Nanjing 211816, China. + + + + Chen + Zhengxing + Z + 0000-0003-0252-6754 + + Key Laboratory of Carbohydrate Chemistry and Biotechnology-Ministry of Education, Jiangnan University, Wuxi 214122, China. + + + National Engineering Research Center for Cereal Fermentation and Food Biomanufacturing, Jiangnan University, Wuxi 214122, China. + + + Jiangsu Provincial Research Centre for Bioactive Product Processing Technology, Jiangnan University, Wuxi 214122, China. + + + School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. + + + + Wu + Chao + C + 0000-0002-4504-4870 + + National Engineering Research Centre of Seafood, Collaborative Innovation Centre of Provincial and Ministerial Co-construction for Seafood Deep Processing, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China. + + + + Zhong + Qixin + Q + + Department of Food Science, University of Tennessee, Knoxville, Tennessee 37996-4539, United States. + + + + Wang + Ren + R + 0000-0003-1317-6593 + + Key Laboratory of Carbohydrate Chemistry and Biotechnology-Ministry of Education, Jiangnan University, Wuxi 214122, China. + + + National Engineering Research Center for Cereal Fermentation and Food Biomanufacturing, Jiangnan University, Wuxi 214122, China. + + + Jiangsu Provincial Research Centre for Bioactive Product Processing Technology, Jiangnan University, Wuxi 214122, China. + + + School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. + + + + Feng + Wei + W + + Key Laboratory of Carbohydrate Chemistry and Biotechnology-Ministry of Education, Jiangnan University, Wuxi 214122, China. + + + National Engineering Research Center for Cereal Fermentation and Food Biomanufacturing, Jiangnan University, Wuxi 214122, China. + + + Jiangsu Provincial Research Centre for Bioactive Product Processing Technology, Jiangnan University, Wuxi 214122, China. + + + School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. + + + + Chen + Xianfu + X + 0000-0002-2506-7493 + + State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Nanjing Tech University, Nanjing 211816, China. + + + + Zhang + Jinliang + J + + State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Nanjing Tech University, Nanjing 211816, China. + + + + Wang + Tao + T + 0000-0002-8924-0232 + + Key Laboratory of Carbohydrate Chemistry and Biotechnology-Ministry of Education, Jiangnan University, Wuxi 214122, China. + + + National Engineering Research Center for Cereal Fermentation and Food Biomanufacturing, Jiangnan University, Wuxi 214122, China. + + + Jiangsu Provincial Research Centre for Bioactive Product Processing Technology, Jiangnan University, Wuxi 214122, China. + + + School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. + + + + Zhang + Zunmin + Z + 0000-0002-0676-1391 + + State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Nanjing Tech University, Nanjing 211816, China. + + + + Binks + Bernard P + BP + 0000-0003-3639-8041 + + Department of Chemistry, University of Hull, Hull HU6 7RX, United Kingdom. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + ACS Nano + 101313589 + 1936-0851 + + IM + + 1D protein−polysaccharide nanostructures + 2D Janus interface + 3D enteric biomaterials + responsive biointerfaces + skin-inspired + +
+ + + + 2023 + 3 + 14 + 13 + 43 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917617 + 10.1021/acsnano.2c11507 + + +
+ + + 36917611 + + 2023 + 03 + 14 + +
+ + 2211-1247 + + 42 + 3 + + 2023 + Mar + 13 + + + Cell reports + Cell Rep + + The human placenta shapes the phenotype of decidual macrophages. + + 112285 + + S2211-1247(23)00296-6 + 10.1016/j.celrep.2023.112285 + + + Vondra + Sigrid + S + + + Höbler + Anna-Lena + AL + + + Lackner + Andreas Ian + AI + + + Raffetseder + Johanna + J + + + Mihalic + Zala Nikita + ZN + + + Vogel + Andrea + A + + + Saleh + Leila + L + + + Kunihs + Victoria + V + + + Haslinger + Peter + P + + + Wahrmann + Markus + M + + + Husslein + Heinrich + H + + + Oberle + Raimund + R + + + Kargl + Julia + J + + + Haider + Sandra + S + + + Latos + Paulina + P + + + Schabbauer + Gernot + G + + + Knöfler + Martin + M + + + Ernerudh + Jan + J + + + Pollheimer + Jürgen + J + + + eng + + Published Erratum + + + 2023 + 03 + 13 + +
+ + United States + Cell Rep + 101573691 + + IM + + + Cell Rep. 2023 Jan 31;42(1):111977 + 36640334 + + +
+ + + + 2023 + 3 + 14 + 13 + 36 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917611 + S2211-1247(23)00296-6 + 10.1016/j.celrep.2023.112285 + + +
+ + + 36917614 + + 2023 + 03 + 14 + +
+ + 1943-569X + + + 2023 + Mar + 18 + + + Journal of the American Veterinary Medical Association + J Am Vet Med Assoc + + Challenges in the diagnosis and management of skin diseases in alpacas, goats, pigs, and sheep. + + 1-9 + + 10.2460/javma.22.12.0572 + + The primary aim of this article is to provide an overview of several selected skin conditions in livestock species. Topics include ectoparasites in alpacas, antler velvet in reindeer, immune-mediated disease in goats, ectoparasites in pigs, Culicoides allergic dermatitis and parapox infection in sheep. When dealing with skin disease in livestock, it is important to collect a detailed history and undertake a thorough clinical examination to include the axilla, groin, limbs and feet. While the diagnosis will often be anticipated from the history and presentation, it is important to consider a differential diagnosis list and appropriate diagnostic testing before embarking on a poly-pharmacy approach to "rule out" causes of disease. This is particularly important where morbidity is high and the livestock of perceived high value to the keeper/owner, such as goats and small-breed pigs, or when the skin condition is long standing/chronic. Ideally, the management plan should sequentially clarify the role of microbial infection and then ectoparasites before considering less common allergic and autoimmune conditions. Skin cytology is an invaluable in-house diagnostic method that can support the findings of culture. Taking skin samples for histopathology and possibly culture may prove valuable once other diagnostic methods have been explored. Given the need to protect the use of parenteral antimicrobials, topical antimicrobial therapies can be deployed successfully. The repeated use of macrocyclic lactones (avermectins) must be balanced in terms of the risks of promoting anthelmintic resistance versus controlling or eradicating the ectoparasites that have, ideally, been specifically identified. + + + + Foster + Aiden P + AP + + + eng + + Journal Article + + + 2023 + 03 + 18 + +
+ + United States + J Am Vet Med Assoc + 7503067 + 0003-1488 + + IM +
+ + + + 2022 + 12 + 19 + + + 2023 + 02 + 06 + + + 2023 + 3 + 14 + 13 + 43 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917614 + 10.2460/javma.22.12.0572 + + +
+ + + 36917615 + + 2023 + 03 + 14 + +
+ + 1943-569X + + + 2023 + Mar + 18 + + + Journal of the American Veterinary Medical Association + J Am Vet Med Assoc + + The epidemiology of antimicrobial resistance and transmission of cutaneous bacterial pathogens in domestic animals. + + 1-8 + + 10.2460/javma.22.12.0557 + + As the primary agents of skin and soft tissue infections in animals, Staphylococcus spp and Pseudomonas aeruginosa are among the most formidable bacterial pathogens encountered by veterinarians. Staphylococci are commensal inhabitants of the surfaces of healthy skin and mucous membranes, which may gain access to deeper cutaneous tissues by circumventing the stratum corneum's barrier function. Compromised barrier function occurs in highly prevalent conditions such as atopic dermatitis, endocrinopathies, and skin trauma. P aeruginosa is an environmental saprophyte that constitutively expresses virulence and antimicrobial resistance genes that promote its success as an animal pathogen. For both organisms, infections of the urinary tract, respiratory tract, joints, central nervous system, and body cavities may occur through ascension along epithelial tracts, penetrating injuries, or hematogenous spread. When treating infections caused by these pathogens, veterinarians now face greater therapeutic challenges and more guarded outcomes for our animal patients because of high rates of predisposing factors for infection and the broad dissemination of antimicrobial resistance genes within these bacterial species. This review considers the history of the rise and expansion of multidrug resistance in staphylococci and P aeruginosa and the current state of knowledge regarding the epidemiologic factors that underly the dissemination of these pathogens across companion animal populations. Given the potential for cross-species and zoonotic transmission of pathogenic strains of these bacteria, and the clear role played by environmental reservoirs and fomites, a one-health perspective is emphasized. + + + + Morris + Daniel O + DO + + Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia,PA. + + + + Cole + Stephen D + SD + + Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA. + + + + eng + + Journal Article + + + 2023 + 03 + 18 + +
+ + United States + J Am Vet Med Assoc + 7503067 + 0003-1488 + + IM +
+ + + + 2022 + 12 + 13 + + + 2023 + 02 + 07 + + + 2023 + 3 + 14 + 13 + 43 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917615 + 10.2460/javma.22.12.0557 + + +
+ + + 36917616 + + 2023 + 03 + 14 + +
+ + 1943-569X + + + 2023 + Mar + 17 + + + Journal of the American Veterinary Medical Association + J Am Vet Med Assoc + + Equine pastern dermatitis: a narrative review on clinical presentation, diagnosis, risk factors, prevention, and therapeutic approaches. + + 1-8 + + 10.2460/javma.22.12.0569 + + Equine pastern dermatitis (EPD) is a nonspecific cutaneous reaction pattern on the distal extremities, typically in the palmar/plantar area of the pastern. Although EPD is commonly seen in equine practice and can be a debilitating condition, peer-reviewed original studies on many aspects of this multifactorial syndrome are still scarce. This narrative review aims to give an overview of the clinical presentation (forms of EPD and clinical scores and differential diagnoses), risk factors, and therapeutic approaches. The emphasis is on intrinsic and extrinsic risk factors as most of the original work has been published on these aspects. The available data supports the effects of age, breed, and breed-related phenotypical traits (draft breeds with feathers and large cannon circumference) on the frequency and severity of EPD manifestations. Hind legs and unpigmented limbs are also more frequently affected. Genetic effects in draft breeds appear to be complex, and no commercial genetic tests currently exist. Evidence for meteorological effects like rainfall and humidity is inconclusive. Associations with Chorioptes infestation and bacterial microbiota imbalances but not with fungal infections have been consistently shown. Causality has not been demonstrated for specific infectious agents. Original studies have investigated the effects of antibacterial agents (Kunzea oil, phytosphingosines, and triclosan), fatty acids, aromatic oils, and humectants as well as therapeutic approaches to Chorioptes infestation in EPD-affected equids. While therapy remains largely empirical, knowledge of investigated risk factors for this multifactorial syndrome can inform diagnostic and therapeutic approaches. Raising owner awareness of EPD could be key to improving the welfare of affected horses. + + + + Gerber + Vinzenz + V + + Department of Clinical Veterinary Medicine, Vetsuisse Faculty, Swiss Institute of Equine Medicine (ISME), University of Bern, Bern, Switzerland. + + + + Kaiser-Thom + Sarah + S + + Department of Clinical Veterinary Medicine, Vetsuisse Faculty, Swiss Institute of Equine Medicine (ISME), University of Bern, Bern, Switzerland. + + + Institute of Immunology, Heidelberg University Hospital, Heidelberg, Germany. + + + + Oesch + Solange + S + + Department of Clinical Veterinary Medicine, Vetsuisse Faculty, Swiss Institute of Equine Medicine (ISME), University of Bern, Bern, Switzerland. + + + + eng + + Journal Article + + + 2023 + 03 + 17 + +
+ + United States + J Am Vet Med Assoc + 7503067 + 0003-1488 + + IM +
+ + + + 2022 + 12 + 18 + + + 2023 + 02 + 03 + + + 2023 + 3 + 14 + 13 + 43 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917616 + 10.2460/javma.22.12.0569 + + +
+ + + 36917621 + + 2023 + 03 + 14 + +
+ + 2050-084X + + 12 + + 2023 + Mar + 14 + + + eLife + Elife + + Beta oscillations and waves in motor cortex can be accounted for by the interplay of spatially-structured connectivity and fluctuating inputs. + 10.7554/eLife.81446 + e81446 + + The beta rhythm (13-30 Hz) is a prominent brain rhythm. Recordings in primates during instructed-delay reaching tasks have shown that different types of traveling waves of oscillatory activity are associated with episodes of beta oscillations in motor cortex during movement preparation. We propose here a simple model of motor cortex based on local excitatory-inhibitory neuronal populations coupled by long-range excitation, where additionally inputs to the motor cortex from other neural structures are represented by stochastic inputs on the different model populations. We show that the model accurately reproduces the statistics of recording data when these external inputs are correlated on a short time scale (25 ms) and have two different components, one that targets the motor cortex locally and another one that targets it in a global and synchronized way. The model reproduces the distribution of beta burst durations, the proportion of the different observed wave types, and wave speeds, which we show not to be linked to axonal propagation speed. When the long-range connectivity or the local input targets are anisotropic, traveling waves are found to preferentially propagate along the axis where connectivity decays the fastest. Different from previously proposed mechanistic explanations, the model suggests that traveling waves in motor cortex are the reflection of the dephasing by external inputs, putatively of thalamic origin, of an oscillatory activity that would otherwise be spatially synchronized by recurrent connectivity. + © 2023, Kang et al. + + + + Kang + Ling + L + http://orcid.org/0000-0001-6532-3773 + + Laboratoire de Physique Statistique, École Normale Supérieure, CNRS, INSERM, Prais, France. + + + + Ranft + Jonas + J + http://orcid.org/0000-0002-7843-7443 + + Institut de Biologie de l'Ecole Normale Supérieure, École Normale Supérieure, CNRS, INSERM, Paris, France. + + + + Hakim + Vincent + V + http://orcid.org/0000-0001-7505-8192 + + Laboratoire de Physique Statistique, École Normale Supérieure, CNRS, INSERM, Paris, France. + + + + eng + + + Graduate Student Fellowship + China Scholarship Council + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + England + Elife + 101579614 + 2050-084X + + IM + + neuroscience + physics of living systems + rhesus macaque + + LK, JR, VH The authors declare that no competing interests exist. +
+ + + + 2022 + 06 + 27 + + + 2023 + 03 + 02 + + + 2023 + 3 + 14 + 13 + 52 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917621 + 10.7554/eLife.81446 + 81446 + + +
+ + + 36917620 + + 2023 + 03 + 14 + +
+ + 1530-6992 + + + 2023 + Mar + 14 + + + Nano letters + Nano Lett + + Moiré-Tile Manipulation-Induced Friction Switch of Graphene on a Platinum Surface. + 10.1021/acs.nanolett.2c03818 + + Friction control and technological advancement are intimately intertwined. Concomitantly, two-dimensional materials occupy a unique position for realizing quasi-frictionless contacts. However, the question arises of how to tune superlubric sliding. Drawing inspiration from twistronics, we propose to control superlubricity via moiré patterning. Friction force microscopy and molecular dynamics simulations unequivocally demonstrate a transition from a superlubric to dissipative sliding regime for different twist angles of graphene moirés on a Pt(111) surface triggered by the normal force. This follows from a novel mechanism at superlattice level where, beyond a critical load, moiré tiles are manipulated in a highly dissipative shear process connected to the twist angle. Importantly, the atomic detail of the dissipation associated with the moiré tile manipulation─i.e., enduring forced registry beyond a critical normal load─allows the bridging of disparate sliding regimes in a reversible manner, thus paving the road for a subtly intrinsic control of superlubricity. + + + + Liu + Zhao + Z + 0000-0002-8376-3374 + + Tianjin Key Lab for Rare Earth Materials and Applications, Center for Rare Earth and Inorganic Functional Materials, School of Materials Science and Engineering, Nankai University, 300350 Tianjin, China. + + + Department of Physics, University of Basel, 4056 Basel, Switzerland. + + + + Vilhena + J G + JG + 0000-0001-8338-9119 + + Department of Physics, University of Basel, 4056 Basel, Switzerland. + + + Departamento de Física Teórica de la Materia Condensada, Universidad Autónoma de Madrid, 28049 Madrid, Spain. + + + + Hinaut + Antoine + A + 0000-0002-2608-2564 + + Department of Physics, University of Basel, 4056 Basel, Switzerland. + + + + Scherb + Sebastian + S + 0000-0002-5479-2715 + + Department of Physics, University of Basel, 4056 Basel, Switzerland. + + + + Luo + Feng + F + + Tianjin Key Lab for Rare Earth Materials and Applications, Center for Rare Earth and Inorganic Functional Materials, School of Materials Science and Engineering, Nankai University, 300350 Tianjin, China. + + + + Zhang + Junyan + J + + State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, 730000 Lanzhou, China. + + + + Glatzel + Thilo + T + 0000-0002-3533-4217 + + Department of Physics, University of Basel, 4056 Basel, Switzerland. + + + + Gnecco + Enrico + E + 0000-0002-3053-923X + + M. Smoluchowksi Institute of Physics, Jagiellonian University in Krakow, 30-348 Krakow, Poland. + + + + Meyer + Ernst + E + 0000-0001-6385-3412 + + Department of Physics, University of Basel, 4056 Basel, Switzerland. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Nano Lett + 101088070 + 1530-6984 + + IM + + Critical normal load + Friction + Graphene + Moiré superlattice + Superlubric−dissipative transition + +
+ + + + 2023 + 3 + 14 + 13 + 43 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917620 + 10.1021/acs.nanolett.2c03818 + + +
+ + + 36917622 + + 2023 + 03 + 14 + +
+ + 1522-9645 + + + 2023 + Mar + 14 + + + European heart journal + Eur Heart J + + Thrombolytic treatment of life-threatening pulmonary embolism in times of alteplase shortage. + ehad120 + 10.1093/eurheartj/ehad120 + + + Klok + Frederikus A + FA + 0000-0001-9961-0754 + + Department of Medicine-Thrombosis and Hemostasis, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands. + + + Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University, Langenbeckstrasse 1, 55131 Mainz, Germany. + + + + Pruszczyk + Piotr + P + 0000-0002-9768-0000 + + Department of Internal Medicine and Cardiology, Medical University of Warsaw, Żwirki i Wigury 61, 02-091 Warsaw, Poland. + + + + Konstantinides + Stavros V + SV + 0000-0001-6359-7279 + + Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University, Langenbeckstrasse 1, 55131 Mainz, Germany. + + + Department of Cardiology, Democritus University of Thrace, Campus 691 00, 68100 Alexandroupolis, Greece. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + England + Eur Heart J + 8006263 + 0195-668X + + IM + Conflict of interest F.A.K. reports grants or contracts from Bayer, BMS, BSCI, MSD, Leo Pharma, Actelion, The Netherlands Organisation for Health Research and Development, The Dutch Thrombosis Association, The Dutch Heart Foundation, and the Horizon Europe Program, all unreacted to this work and paid to his institution. P.P. received consultancy and lecture honoraria from Boehringer Ingelheim, Boston Scientific, Bayer Healthcare, and BMS–Pfizer; S.V.K. reports institutional grants or contracts from Bayer AG and Daiichi Sankyo; consulting fees from Bayer AG, Daiichi Sankyo, and Boston Scientific; and lecture honoraria from Bayer AG, MSD, Pfizer, and Bristol–Myers Squibb. +
+ + + + 2022 + 08 + 16 + + + 2022 + 12 + 21 + + + 2023 + 01 + 19 + + + 2023 + 3 + 14 + 13 + 52 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917622 + 7077457 + 10.1093/eurheartj/ehad120 + + +
+ + + 36917623 + + 2023 + 03 + 14 + +
+ + 1559-2863 + + + 2023 + Mar + 10 + + + Operative dentistry + Oper Dent + + Effectiveness and Color Stability of Resin Infiltration on Demineralized and Hypomineralized (MIH) Enamel in Children: Six-month Results of a Prospective Trial. + 10.2341/22-041-C + + To evaluate the masking effect and color stability of resin infiltration treatment in demineralized (white spot lesion) and hypomineralized (molar incisor hypomineralization) enamel lesions of young permanent anterior teeth. + Eighty-four (84) anterior teeth with molar incisor hypomineralization or white spot lesions were treated with resin infiltration. The CIE L*a*b* values of sound enamel and enamel lesions were assessed with spectrophotometer and digital image analysis at baseline, immediate postop, 1 week and 6 months. The difference in ΔL, Δa, Δb, and ΔE measurements between sound enamel and the enamel lesions was compared using the repeated analysis of variance (ANOVA) test at p < 0.05. + The enamel lesions were clearly discernible from the sound adjacent enamel at baseline. After resin infiltration, there was a significant drop in ΔE values of sound enamel and enamel lesions compared to baseline, and this difference did not change for 6 months, indicating a durable masking effect. At baseline and after 6 months, there was no significant difference in the ΔE values of the test groups. + The demineralized and hypomineralized enamel defects were effectively masked by resin infiltration, which remained clinically stable for 6 months. + © Operative Dentistry, 2023. + + + + Ozgur + B + B + + Beste Ozgur, assistant professor, Department of Pediatric Dentistry, Hacettepe University Faculty of Dentistry, Ankara, Turkey. + + + + Erbas Unverdi + G + G + + Gizem Erbas Unverdi, assistant professor, Department of Pediatric Dentistry, Hacettepe University Faculty of Dentistry, Ankara, Turkey. + + + + Ertan + A A + AA + + Ahmet Atila Ertan, professor, Department of Prosthodontics, Hacettepe University Faculty of Dentistry, Ankara, Turkey. + + + + Cehreli + Z C + ZC + + *Zafer C Cehreli, DDS, PhD, professor, Department of Pediatric Dentistry, Hacettepe University Faculty of Dentistry, Ankara, Turkey. + + + + eng + + Journal Article + + + 2023 + 03 + 10 + +
+ + United States + Oper Dent + 7605679 + 0361-7734 + +
+ + + + 2022 + 07 + 20 + + + 2023 + 3 + 14 + 13 + 52 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917623 + 491445 + 10.2341/22-041-C + + +
+ + + 36917625 + + 2023 + 03 + 14 + +
+ + 0748-321X + + + 2023 + Mar + 13 + + + Journal of veterinary medical education + J Vet Med Educ + + Factors Influencing Effective Communication between Stakeholder Groups during DVM Work-Based Learning Program in Bangladesh. + + e20220101 + + 10.3138/jvme-2022-0101 + + This study aimed to review the existing communication systems between the universities, placement providers, and students during the DVM final year work-based learning (WBL) program in Bangladesh. The intention was to identify what factors impact the effectiveness of the communication system and to explore ways to enhance communication to better support the program. A questionnaire was used to collect details about the WBL program and the communication systems from all universities in Bangladesh. The questionnaire was completed on paper at a meeting of the National Veterinary Dean Council and online with a member of each university's WBL coordination team. A summary of the current WBL programs in Bangladesh was produced. Focus group discussions were used to collect more detailed information about the communication systems and were held via Zoom with recent graduates (n = 16) and placement providers (n = 7). Effective means of communication between all stakeholders were identified as an initial letter, phone calls, and spot visits by teachers. However, the frequency of formal communication before and during placements was variable and the ways of providing feedback on the communication systems were insufficient. These issues sometimes undermined the student learning experience. Suggestions for improvements included increased resourcing, greater use of online communication systems, and a national committee to oversee WBL. Other ways to motivate placement providers included a better honorarium and continuing education courses. The results suggest that existing communication systems for veterinary WBL in Bangladesh are not completely satisfactory. Measures are needed to improve communication to optimize the student learning experience and capitalize on the many benefits of the WBL program for all stakeholders. + + + + Mohsin + Md Abu Shoieb + MAS + 0000-0003-4175-3511 + + Chattogram Veterinary and Animal Sciences University, Zakir Hossain Road, Khulshi, Chattogram-4225, Bangladesh. + + + + Hoque + Md Ahasanul + MA + 0000-0002-4407-1404 + + Chattogram Veterinary and Animal Sciences University, Zakir Hossain Road, Khulshi, Chattogram-4225, Bangladesh. + + + + Sattar + Abdullah Al + AA + 0000-0002-3255-4601 + + Chattogram Veterinary and Animal Sciences University, Zakir Hossain Road, Khulshi, Chattogram-4225, Bangladesh. + + + + Baillie + Sarah + S + 0000-0002-8665-8369 + + Bristol Veterinary School, University of Bristol, Langford House, Langford, Bristol BS40 5DU, UK. + + + + eng + + Journal Article + + + 2023 + 03 + 13 + +
+ + Canada + J Vet Med Educ + 7610519 + 0748-321X + + IM + + Bangladesh + clinical training + communication + community based training + placements + veterinary education + work-based learning + +
+ + + + 2023 + 3 + 14 + 13 + 53 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917625 + 10.3138/jvme-2022-0101 + + +
+ + + 36917624 + + 2023 + 03 + 14 + +
+ + 1469-8749 + + + 2023 + Mar + 14 + + + Developmental medicine and child neurology + Dev Med Child Neurol + + Parent-led massage and sleep EEG for term-born infants: A randomized controlled parallel-group study. + 10.1111/dmcn.15565 + + To examine the impact of parent-led massage on the sleep electroencephalogram (EEG) features of typically developing term-born infants at 4 months. + Infants recruited at birth were randomized to intervention (routine parent-led massage) and control groups. Infants had a daytime sleep EEG at 4 months and were assessed using the Griffiths Scales of Child Development, Third Edition at 4 and 18 months. Comparative analysis between groups and subgroup analysis between regularly massaged and never-massaged infants were performed. Groups were compared for sleep stage, sleep spindles, quantitative EEG (primary analysis), and Griffiths using the Mann-Whitney U test. + In total, 179 out of 182 infants (intervention: 83 out of 84; control: 96 out of 98) had a normal sleep EEG. Median (interquartile range) sleep duration was 49.8 minutes (39.1-71.4) (n = 156). A complete first sleep cycle was seen in 67 out of 83 (81%) and 72 out of 96 (75%) in the intervention and control groups respectively. Groups did not differ in sleep stage durations, latencies to sleep and to rapid eye movement sleep. Sleep spindle spectral power was greater in the intervention group in main and subgroup analyses. The intervention group showed greater EEG magnitudes, and lower interhemispherical coherence on subgroup analyses. Griffiths assessments at 4 months (n = 179) and 18 months (n = 173) showed no group differences in the main and subgroup analyses. + Routine massage is associated with distinct functional brain changes at 4 months. + © 2023 The Authors. Developmental Medicine & Child Neurology published by John Wiley & Sons Ltd on behalf of Mac Keith Press. + + + + Ventura + Soraia + S + https://orcid.org/0000-0003-2662-1924 + + INFANT Research Centre, University College Cork, Cork, Ireland. + + + Department of Paediatrics & Child Health, University College Cork, Cork, Ireland. + + + + Mathieson + Sean R + SR + https://orcid.org/0000-0001-6498-6620 + + INFANT Research Centre, University College Cork, Cork, Ireland. + + + Department of Paediatrics & Child Health, University College Cork, Cork, Ireland. + + + + O'Sullivan + Marc P + MP + https://orcid.org/0000-0002-6184-3306 + + INFANT Research Centre, University College Cork, Cork, Ireland. + + + Department of Paediatrics & Child Health, University College Cork, Cork, Ireland. + + + Luxembourg Institute of Health, Strassen, Luxembourg. + + + + O'Toole + John M + JM + https://orcid.org/0000-0001-9021-1183 + + INFANT Research Centre, University College Cork, Cork, Ireland. + + + Department of Paediatrics & Child Health, University College Cork, Cork, Ireland. + + + + Livingstone + Vicki + V + https://orcid.org/0000-0002-3309-1231 + + INFANT Research Centre, University College Cork, Cork, Ireland. + + + Department of Paediatrics & Child Health, University College Cork, Cork, Ireland. + + + + Pressler + Ronit M + RM + https://orcid.org/0000-0002-2905-6839 + + Department of Clinical Neurophysiology, Great Ormond Street Hospital NHS Trust, London, UK. + + + Developmental Neurosciences, UCL Great Ormond Street Institute of Child Health, London, UK. + + + + Dempsey + Eugene M + EM + https://orcid.org/0000-0002-6266-3462 + + INFANT Research Centre, University College Cork, Cork, Ireland. + + + Department of Paediatrics & Child Health, University College Cork, Cork, Ireland. + + + + Murray + Deirdre M + DM + https://orcid.org/0000-0002-2201-9912 + + INFANT Research Centre, University College Cork, Cork, Ireland. + + + Department of Paediatrics & Child Health, University College Cork, Cork, Ireland. + + + + Boylan + Geraldine B + GB + https://orcid.org/0000-0003-0920-5291 + + INFANT Research Centre, University College Cork, Cork, Ireland. + + + Department of Paediatrics & Child Health, University College Cork, Cork, Ireland. + + + + eng + + + Johnson and Johnson + + + + 12/RC/2272 + Science Foundation Ireland + Ireland + + + 15/SP/3091 + Science Foundation Ireland + Ireland + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + England + Dev Med Child Neurol + 0006761 + 0012-1622 + + IM +
+ + + + 2023 + 01 + 27 + + + 2022 + 08 + 30 + + + 2023 + 01 + 30 + + + 2023 + 3 + 14 + 13 + 52 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917624 + 10.1111/dmcn.15565 + + + REFERENCES + + Stiles J, Jernigan TL. The basics of brain development. Neuropsychol Rev. 2010;20:327-48. https://doi.org/10.1007/s11065-010-9148-4. + + + Sale A. A Systematic Look at Environmental Modulation and Its Impact in Brain Development. Trends Neurosci. 2018;41:4-17. https://doi.org/10.1016/j.tins.2017.10.004. + + + Guzzetta A, Baldini S, Bancale A, Baroncelli L, Ciucci F, Ghirri P, et al. Massage accelerates brain development and the maturation of visual function. J Neurosci. 2009;29:6042-51. https://doi.org/10.1523/JNEUROSCI.5548-08.2009. + + + Field T, Grizzle N, Scafidi F, Abrams S, Richardson S, Kuhn C, et al. Massage therapy for infants of depressed mothers. Infant Behav Dev. 1996;19:107-12. https://doi.org/10.1016/S0163-6383(96)90048-X. + + + Guzzetta A, D'Acunto MG, Carotenuto M, Berardi N, Bancale A, Biagioni E, et al. The effects of preterm infant massage on brain electrical activity. Dev Med Child Neurol. 2011;53 Suppl 4:46-51. https://doi.org/10.1111/j.1469-8749.2011.04065.x. + + + Lai M, D'Acunto G, Guzzetta A, Finnigan S, Ngenda N, Ware RS, et al. Infant massage and brain maturation measured using EEG: A randomised controlled trial. Early Hum Dev. 2022;172:105632. https://doi.org/10.1016/j.earlhumdev.2022.105632. + + + Fernandez LMJ, Lüthi A. Sleep Spindles: Mechanisms and Functions. Physiol Rev. 2020;100:805-68. https://doi.org/10.1152/physrev.00042.2018. + + + Kurth S, Ringli M, Geiger A, LeBourgeois M, Jenni OG, Huber R. Mapping of cortical activity in the first two decades of life: a high-density sleep electroencephalogram study. J Neurosci. 2010;30:13211-9. https://doi.org/10.1523/JNEUROSCI.2532-10.2010. + + + Ventura S, Mathieson SR, O'Toole JM, Livingstone V, Ryan M-A, Boylan GB. Electroencephalographic sleep macrostructure and sleep spindles in early infancy. Sleep. 2021;45(1). https://doi.org/10.1093/sleep/zsab262. + + + Berry RB, Brooks R, Gamaldo C, Harding SM, Lloyd RM, Quan SF, et al. The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications. Version 2.4. Darien, IL: American Academy of Sleep and Associated Events; 2017. + + + van Putten MJ. The revised brain symmetry index. Clin Neurophysiol. 2007;118:2362-7. https://doi.org/10.1016/j.clinph.2007.07.019. + + + O'Toole JM, Boylan GB. Quantitative Preterm EEG Analysis: The Need for Caution in Using Modern Data Science Techniques. Front Pediatr. 2019;7:174. https://doi.org/10.3389/fped.2019.00174. + + + O'Toole JM, Boylan GB. NEURAL: quantitative features for newborn EEG using Matlab. 2017:[arXiv:1704.05694v1]. + + + Condon JT, Corkindale CJ. The assessment of parent-to-infant attachment: Development of a self-report questionnaire instrument. J Reprod Infant Psychol. 1998;16(1):57-76. https://doi.org/10.1080/02646839808404558. + + + Cox JL, Holden JM, Sagovsky R. Detection of postnatal depression: development of the 10-item Edinburgh Postnatal Depression Scale. Br J Psychiatry. 1987;150:782-6. https://doi.org/10.1192/bjp.150.6.782 + + + Althouse AD. Adjust for Multiple Comparisons? It's Not That Simple. Ann Thorac Surg. 2016;101:1644-5. https://doi.org/10.1016/j.athoracsur.2015.11.024. + + + Rothman KJ. No adjustments are needed for multiple comparisons. Epidemiology. 1990;1:43-6. + + + Korotchikova I, Stevenson NJ, Livingstone V, Ryan CA, Boylan GB. Sleep-wake cycle of the healthy term newborn infant in the immediate postnatal period. Clin Neurophysiol. 2016;127:2095-101. https://doi.org/10.1016/j.clinph.2015.12.015. + + + Bennett C, Underdown A, Barlow J. Massage for promoting mental and physical health in typically developing infants under the age of six months. Cochrane Database Syst Rev. 2013;4:CD005038-CD. https://doi.org/10.1002/14651858.CD005038.pub3. + + + Raineki C, Lucion AB, Weinberg J. Neonatal handling: an overview of the positive and negative effects. Dev Psychobiol. 2014;56:1613-25. https://doi.org/10.1002/dev.21241. + + + Szyf M, Weaver I, Meaney M. Maternal care, the epigenome and phenotypic differences in behavior. Reprod Toxicol. 2007;24:9-19. https://doi.org/10.1016/j.reprotox.2007.05.001. + + + Liu D, Diorio J, Day JC, Francis DD, Meaney MJ. Maternal care, hippocampal synaptogenesis and cognitive development in rats. Nat Neurosci. 2000;3:799-806. https://doi.org/10.1038/77702. + + + Sheinkopf SJ, Tenenbaum EJ, Messinger DS, Miller-Loncar CL, Tronick E, Lagasse LL, et al. Maternal and infant affect at 4 months predicts performance and verbal IQ at 4 and 7 years in a diverse population. Dev Sci. 2017;20:e12479. https://doi.org/10.1111/desc.12479. + + + Gunnar M, Quevedo K. The neurobiology of stress and development. Annu Rev Psychol. 2007;58:145-73. https://doi.org/10.1146/annurev.psych.58.110405.085605. + + + Louis J, Zhang JX, Revol M, Debilly G, Challamel MJ. Ontogenesis of nocturnal organization of sleep spindles: a longitudinal study during the first 6 months of life. Electroencephalogr Clin Neurophysiol. 1992;83:289-96. https://doi.org/10.1016/0013-4694(92)90088-y. + + + Piantoni G, Poil S-S, Linkenkaer-Hansen K, Verweij IM, Ramautar JR, Van Someren EJ, et al. Individual differences in white matter diffusion affect sleep oscillations. J Neurosci. 2013;33:227-33. https://doi.org/10.1523/JNEUROSCI.2030-12.2013. + + + Lebel C, Treit S, Beaulieu C. A review of diffusion MRI of typical white matter development from early childhood to young adulthood. NMR Biomed. 2019;32:e3778. https://doi.org/10.1002/nbm.3778. + + + Rosas HD, Lee SY, Bender AC, Zaleta AK, Vangel M, Yu P, et al. Altered white matter microstructure in the corpus callosum in Huntington's disease: Implications for cortical “disconnection”. Neuroimage. 2010;49:2995-3004. https://doi.org/10.1016/j.neuroimage.2009.10.015. + + + Della Nave R, Ginestroni A, Diciotti S, Salvatore E, Soricelli A, Mascalchi M. Axial diffusivity is increased in the degenerating superior cerebellar peduncles of Friedreich's ataxia. Neuroradiology. 2011;53:367-72. https://doi.org/10.1007/s00234-010-0807-1. + + + Luo L, O'Leary DD. Axon retraction and degeneration in development and disease. Annu Rev Neurosci. 2005;28:127-56. https://doi.org/10.1146/annurev.neuro.28.061604.135632. + + + Geiger A, Huber R, Kurth S, Ringli M, Jenni OG, Achermann P. The Sleep EEG as a Marker of Intellectual Ability in School Age Children. Sleep. 2011;34:181-9. https://doi.org/10.1093/sleep/34.2.181. + + + Gruber R, Wise MS, Frenette S, Knäauper B, Boom A, Fontil L, et al. The association between sleep spindles and IQ in healthy school-age children. Int J Psychophysiol. 2013;89:229-40. https://doi.org/10.1016/j.ijpsycho.2013.03.018. + + + Peyrache A, Seibt J. A mechanism for learning with sleep spindles. Philos Trans R Soc Lond B Biol Sci. 2020;375. https://doi.org/10.1098/rstb.2019.0230 + + + Chu CJ, Leahy J, Pathmanathan J, Kramer MA, Cash SS. The maturation of cortical sleep rhythms and networks over early development. Clin Neurophysiol. 2014;125:1360-70. https://doi.org/10.1016/j.clinph.2013.11.028. + + + Thatcher RW, North DM, Biver CJ. Self-organized criticality and the development of EEG phase reset. Hum Brain Mapp. 2009;30:553-74. https://doi.org/10.1002/hbm.20524. + + + Xiao R, Shida-Tokeshi J, Vanderbilt DL, Smith BA. Electroencephalography power and coherence changes with age and motor skill development across the first half year of life. PLoS One. 2018;13. https://doi.org/10.1371/journal.pone.0190276. + + + Boersma M, Smit DJ, de Bie HM, Van Baal GCM, Boomsma DI, de Geus EJ, et al. Network analysis of resting state EEG in the developing young brain: structure comes with maturation. Hum Brain Mapp. 2011;32:413-25. https://doi.org/10.1002/hbm.21030. + + + Emerson RW, Gao W, Lin W. Longitudinal study of the emerging functional connectivity asymmetry of primary language regions during infancy. J Neurosci. 2016;36:10883-92. https://doi.org/10.1523/JNEUROSCI.3980-15.2016. + + + +
+ + + 36917627 + + 2023 + 03 + 14 + +
+ + 1522-9645 + + + 2023 + Mar + 14 + + + European heart journal + Eur Heart J + + Great Debate: Computed tomography coronary angiography should be the initial diagnostic test in suspected angina. + ehac597 + 10.1093/eurheartj/ehac597 + + + Patel + Toral R + TR + + + Villines + Todd + T + + + Kramer + Christopher M + CM + + + Kwong + Raymond Y + RY + + + Raharjo + Daniell Edward + DE + + + Kunadian + Vijay + V + + + Berry + Colin + C + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + England + Eur Heart J + 8006263 + 0195-668X + + IM +
+ + + + 2023 + 3 + 14 + 13 + 53 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917627 + 7077456 + 10.1093/eurheartj/ehac597 + + +
+ + + 36917628 + + 2023 + 03 + 14 + +
+ + 2157-6580 + + + 2023 + Mar + 14 + + + Stem cells translational medicine + Stem Cells Transl Med + + A Novel Approach for Determining the Critical Quality Attributes of Mesenchymal Stem Cells by Specifying Cell Population With Replication Potential. + szad005 + 10.1093/stcltm/szad005 + + We introduce a novel approach to determine the critical quality attributes (CQAs) of mesenchymal stem cells (MSCs) expected to exert immunosuppressive effects. MSCs retained homeostatic replication potentials, such as sustainable growth and consistent cell morphology as a population, in early passages, but lost them in late passages. Characteristic surface markers of MSCs (ie, CD73, CD90, and CD105) were no longer expressed at 2 weeks after subcutaneous transplantation into NOG mice when MSCs from late passages were transplanted, but not when MSCs from early passages were transplanted, suggesting that the biological effects of the MSCs differed according to the timing of cell harvesting and highlighting the importance of specifying MSCs that retained homeostatic features to define the CQAs. The homeostatic features of MSCs related to the balance of the redox system, nutrient requirements, and mitochondrial function were also observed until a certain passage. Therefore, we could define the CQAs of MSCs related to manufacturing by selecting process parameters (PPs) underlying the homeostatic features of MSCs and measuring these PPs quantitatively to specify the cell population with homeostatic features by limiting the passage number. The validity of the PPs stipulated in our pilot study was verified using an SKG murine arthritis model, and critical PPs (CPPs) were then selected among the PPs. Thus, CQAs related to manufacturing in the developmental phase could be defined by the CPPs in this manner, and the concept of CQAs could be refined continuously toward commercial manufacturing. + © The Author(s) 2023. Published by Oxford University Press. + + + + Yamamoto + Takako + T + 0000-0002-1877-0359 + + R&D Center for Cell Therapy, Foundation for Biomedical Research and Innovation, Kobe, Japan. + + + + Arita + Mao + M + + R&D Center for Cell Therapy, Foundation for Biomedical Research and Innovation, Kobe, Japan. + + + + Tamura + Takashi + T + + R&D Center for Cell Therapy, Foundation for Biomedical Research and Innovation, Kobe, Japan. + + + + Saito + Miho + M + + R&D Center for Cell Therapy, Foundation for Biomedical Research and Innovation, Kobe, Japan. + + + + Katayama + Hirohito + H + + Novartis Pharma KK, Tokyo, Japan. + + + + Kuroda + Hirotaka + H + + Shimadzu Corp., Kyoto, Japan. + + + Graduate School of Engineering, Osaka University, Osaka, Japan. + + + + Suzuki + Takashi + T + + Shimadzu Corp., Kyoto, Japan. + + + + Kawamata + Shin + S + + R&D Center for Cell Therapy, Foundation for Biomedical Research and Innovation, Kobe, Japan. + + + + eng + + + JP22be0704001 + AMED + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + England + Stem Cells Transl Med + 101578022 + 2157-6564 + + IM + + Redox system + critical process parameter + critical quality attribute + mesenchymal stem cells + mitochondrial function + +
+ + + + 2022 + 09 + 27 + + + 2023 + 01 + 19 + + + 2023 + 3 + 14 + 13 + 53 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917628 + 7077454 + 10.1093/stcltm/szad005 + + +
+ + + 36917626 + + 2023 + 03 + 14 + +
+ + 1549-490X + + + 2023 + Mar + 14 + + + The oncologist + Oncologist + + Patients' Perceptions Regarding the Relevance of Items Contained in the Functional Assessment of Cancer Therapy Kidney Symptom Index-19. + oyad028 + 10.1093/oncolo/oyad028 + + There is a lack of consensus regarding the optimal method of assessing health-related quality of life (HR-QOL) among patients with metastatic renal cell carcinoma (mRCC). This study explored the perceived relevance of items that make up the Functional Assessment of Cancer Therapy Kidney Symptom Index-19 (FKSI-19), as judged by patients with mRCC. + This was a multinational cross-sectional survey. Eligible patients responded to a questionnaire composed of 18 items that assessed the perceived relevance of each item in the FKSI-19 questionnaire. Open-ended questions assessed additional issues deemed relevant by patients. Responses were grouped as relevant (scores 2-5) or nonrelevant (score 1). Descriptive statistics were collated, and open-ended questions were analyzed and categorized into descriptive categories. Spearman correlation statistics were used to test the association between relevance and clinical characteristics. + A total of 151 patients were included (gender: 78.1 M, 21.9F; median age: 64; treatment: 38.4 immunotherapy, 29.8 targeted therapy, 13.9 immuno-TKI combination therapy) in the study. The most relevant questions evaluated fatigue (77.5), lack of energy (72.2), and worry that their condition will get worse (71.5). Most patients rated blood in urine (15.2), fevers (16.6), and lack of appetite (23.2) as least relevant. Qualitative analysis of open-ended questions revealed several themes, including emotional and physical symptoms, ability to live independently, effectiveness of treatment, family, spirituality, and financial toxicity. + There is a need to refine widely used HR-QOL measures that are employed among patients diagnosed with mRCC treated with contemporary therapies. Guidance was provided for the inclusion of more relevant items to patients' cancer journey. + © The Author(s) 2023. Published by Oxford University Press. + + + + Bergerot + Cristiane Decat + CD + 0000-0003-0037-0303 + + Centro de Câncer de Brasília, Instituto Unity de Ensino e Pesquisa, Brasília, DF, Brazil. + + + + Malhotra + Jasnoor + J + + Department of Medical Oncology & Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, CA, USA. + + + + Bergerot + Paulo + P + + Centro de Câncer de Brasília, Instituto Unity de Ensino e Pesquisa, Brasília, DF, Brazil. + + + + Philip + Errol J + EJ + + School of Medicine, University of California San Francisco, San Francisco, CA, USA. + + + + Castro + Daniela V + DV + + Department of Medical Oncology & Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, CA, USA. + + + + Hsu + JoAnn + J + + Department of Medical Oncology & Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, CA, USA. + + + + Mota + Augusto Cesar de Andrade + ACA + + Medical Oncology, Clinica AMO, Salvador, BA, Brazil. + + + + Cardoso de Azeredo + Andressa + A + + Medical Oncology, Instituto de Oncologia Kaplan, Porto Alegre, RS, Brazil. + + + + Neto + João Nunes de Matos + JNM + + Centro de Câncer de Brasília, Instituto Unity de Ensino e Pesquisa, Brasília, DF, Brazil. + + + + Hutson + Thomas + T + + Urologic Oncology Program, Texas Oncology at Baylor Sammons Cancer Center, Dallas, TX, USA. + + + + Grünwald + Viktor + V + + Clinic for Medical Oncology, Clinic for Urology, University Hospital Essen, Essen, Alemanha, Germany. + + + + Bex + Axel + A + + UCL Division of Surgical and Interventional Science, The Netherlands Cancer Institute, Amsterdam, The Netherlands. + + + + Psutka + Sarah P + SP + + Urology Clinic, University of Washington, Seattle, WA, USA. + + + + Rini + Brian + B + + Department of Medicine, Vanderbilt-Ingram Cancer Center, Nashville, TN, USA. + + + + Plimack + Elizabeth R + ER + + Department of Hematology/Oncology and Chief, Fox Chase Cancer Center, Philadelphia, PA, USA. + + + + Master + Viraj + V + + Department of Urology, Emory University Hospital, Atlanta, GA, USA. + + + + Albiges + Laurence + L + 0000-0002-5734-3480 + + Department of Cancer Medicine, Gustave Roussy Institute, Paris, France. + + + + Choueiri + Toni K + TK + 0000-0002-9201-3217 + + Lank Center for Genitourinary (GU) Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. + + + + Pal + Sumanta + S + + Department of Medical Oncology & Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, CA, USA. + + + + Powles + Thomas + T + + Barts Cancer Centre, Barts Cancer Centre at St. Bartholomew's Hospital, London, UK. + + + + eng + + + Kidney Cancer Association + + + + + Journal Article + + + 2023 + 03 + 14 + +
+ + England + Oncologist + 9607837 + 1083-7159 + + IM + + Functional Assessment of Cancer Therapy Kidney Symptom Index-19 + health care survey + health-related quality of life + patient-reported outcomes + renal cell carcinoma + +
+ + + + 2022 + 12 + 08 + + + 2023 + 01 + 06 + + + 2023 + 3 + 14 + 13 + 53 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917626 + 7077455 + 10.1093/oncolo/oyad028 + + +
+ + + 36917633 + + 2023 + 03 + 14 + +
+ + 1559-2863 + + + 2023 + Mar + 10 + + + Operative dentistry + Oper Dent + + Effect of Using Manufacturer-recommended Exposure Times to Photo-activate Bulk-fill and Conventional Resin-based Composites. + 10.2341/22-021-L + + To analyze the effect of using the resin-based composite manufacturer's recommended exposure time on the degree of conversion (DC), Knoop hardness (KH), and elastic modulus (E) of conventional and bulk-fill resin-based composites (RBCs). + Three resin-based composites (RBCs) were tested: Tetric EvoCeram Bulk Fill (TET), Opus Bulk Fill APS (OPU), and RBC Vittra APS (VIT). They were photo-activated in 2 mm deep, 6 mm diameter molds for their recommended exposure times of 10 seconds, 20 seconds, or 40 seconds from four light-curing units (LCUs). Two delivered a single emission peak in the blue light region (Optilight Max and Radii-Cal) and two delivered multiple emission peaks in the violet and blue region (VALO Cordless and Bluephase G2). After 24 hours of dry storage at 37°C in the dark, the KH (Kgf/mm2), E (MPa) and DC (%) at the top and bottom surfaces of specimens (n=5) were measured and the results analyzed by 2-way analysis of variance (ANOVA) followed by a Tukey test (α=0.05). + The irradiance (mW/cm2) and spectral irradiance (mW/cm2/nm) from the LCUs were reduced significantly (8-35%) after passing through 2.0 mm of RBC (p<0.001). The DC at the bottom of VIT and TET was less than at the top surface (p<0.001). OPU had the same DC at the top and bottom surface (p=0.341). The KH and E values at the top surface of VIT and TET were substantially higher than at the bottom (p<0.001). OPU exposed for 40 seconds achieved higher mechanical properties than TET that was photo-activated for 10 seconds (p<0.001). The opacity of different bulk-fill RBCs changed differently during the polymerization; OPU became more opaque, whereas TET became more transparent. When exposed for their recommended times, the 2 mm thick RBCs that used Ivocerin or the APS photoinitiator system were adequately photo-activated using either the single or multiple emission peak LCUs (p=0.341). + After 24 hours' storage, all the 2 mm thick RBCs photo-cured in 6 mm diameter molds achieved a bottom-to-top hardness ratio of at least 80% when their recommended exposure times were used. TET, when photo-activated for 10 seconds, achieved lower mechanical properties than OPU that had been photo-activated for 40 seconds. The change in opacity of the RBCs was different during photo-activation. + © Operative Dentistry, 2023. + + + + Barcelos + L M + LM + + Luciana Mendes Barcelos, DDS, MSc, PhD, Department of Operative Dentistry and Dental Materials, Dental School, Federal University of Uberlândia, Minas Gerais, Brazil. + + + + Braga + Ssl + S + + Stella Sueli Loureiro Braga, DDS, MSc, PhD, Department of Operative Dentistry and Dental Materials, Dental School, Federal University of Uberlândia, Minas Gerais, Brazil. + + + + Pereira + Ras + R + + Renata Afonso da Silva Pereira, DDS, MSc, PhD, Department of Operative Dentistry and Dental Materials, Dental School, Federal University of Uberlândia, Minas Gerais, Brazil. + + + + Price + R B + RB + + Richard Bengt Price, DDS, PhD, Department of Dental Clinical Sciences, Dalhousie University, Halifax, Nova Scotia, Canada. + + + + Soares + C J + CJ + + *Carlos José Soares, Department of Operative Dentistry and Dental Materials, Dental School, Federal University of Uberlândia, Minas Gerais, Brazil. + + + + eng + + Journal Article + + + 2023 + 03 + 10 + +
+ + United States + Oper Dent + 7605679 + 0361-7734 + +
+ + + + 2022 + 10 + 24 + + + 2023 + 3 + 14 + 13 + 53 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917633 + 491443 + 10.2341/22-021-L + + +
+ + + 36917629 + + 2023 + 03 + 14 + +
+ + 1559-2863 + + + 2023 + Mar + 10 + + + Operative dentistry + Oper Dent + + Gingival Conditioning with Provisional Composite Veneer Prior to Final Dental Restoration: Three-year Follow-up. + 10.2341/21-116-S + + This manuscript reports a three-year follow-up of a case of gingival conditioning with a provisional composite veneer prior to diastema closure and tooth recontouring with direct composites. This conservative treatment resulted in a natural and harmonious smile. + © Operative Dentistry, 2023. + + + + Mueller + B + B + + *Bruna Mueller, DDS, MS, PhD student, Department of Dentistry and Implant Dentistry, Federal University of Santa Catarina, Florianópolis, SC, Brazil. + + + + Rauber + G B + GB + + Gabrielle Branco Rauber, DDS, MS, PhD, Department of Dentistry, Federal University of Santa Catarina, Florianópolis, SC, Brazil. + + + + Linhares + L A + LA + + Ludmilla de Azevedo Linhares, DDS, MS, PhD, Department of Dentistry, Federal University of Santa Catarina, Florianópolis, SC, Brazil. + + + + Bernardon + J K + JK + + Jussara Karina Bernadon, DDS, MS, PhD, associate professor, Department of Dentistry, Federal University of Santa Catarina, Florianópolis, SC, Brazil. + + + + Santini + E + E + + Eduardo Santini, DDS, MS student, Department of Implant Dentistry at São Leopoldo Mandic, Campinas, SP, Brazil. + + + + Pottmaier + L F + LF + + Larissa Fernanda Pottmaier, DDS, MS, PhD, Department of Dentistry, Federal University of Santa Catarina, Florianópolis, SC, Brazil. + + + + eng + + Journal Article + + + 2023 + 03 + 10 + +
+ + United States + Oper Dent + 7605679 + 0361-7734 + +
+ + + + 2022 + 10 + 24 + + + 2023 + 3 + 14 + 13 + 53 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917629 + 491446 + 10.2341/21-116-S + + +
+ + + 36917631 + + 2023 + 03 + 14 + +
+ + 1559-2863 + + + 2023 + Mar + 10 + + + Operative dentistry + Oper Dent + + Polychromatic Composite and Resin Infiltration Restorations in the Esthetic Zone: A Five-year Clinical Report. + 10.2341/22-033-S + + This case report describes the use of a combination of a polychromatic resin composite restoration and resin infiltration to achieve a satisfactory esthetic outcome that has lasted over five years. + The patient's primary complaint was a desire to replace an existing stained resin composite on the facial and mesial surfaces of the maxillary left central incisor, and a white spot on the facial surface of the maxillary right central incisor. After clinical evaluation, the patient was offered either replacement of the restoration with a polychromatic restoration simulating a white spot, or a combined treatment with polychromatic composite and resin infiltration restorations, which was recommended. The patient selected the latter treatment. A putty matrix was fabricated, and a quick mock-up was done using various enamel and dentin shades of resin composite to determine proper material selection. The previous resin composite restoration was removed, and layers of new dentin, body, and enamel composite were placed. An interproximal matrix was used in order to provide ideal contour and contact. Finishing and polishing procedures were performed. The maxillary right central incisor was treated with resin infiltration in order to subdue the white spot on the facial surface. + Polychromatic resin composite and resin infiltration restorations to replace a stained restoration and mask a white spot can achieve desired results in the esthetic zone and maintain them for five years. + © Operative Dentistry, 2023. + + + + Karimi + K + K + + Kiarash Karimi, DDS, DMD, adjunct faculty, University of California Los Angeles School of Dentistry, Los Angeles, CA, USA. + + + + Fischer + N G + NG + + *Nicholas G Fischer, PhD, fellow, Minnesota Dental Research Center for Biomaterials and Biomechanics, University of Minnesota, Minneapolis, MN, USA. + + + + Jurado + C A + CA + + Carlos Alberto Jurado, DDS, MS, associate professor at University of Iowa College of Dentistry, Iowa City, IA, USA. + + + + Villalobos-Tinoco + J + J + + Jose Villalobos-Tinoco, DDS, MS, assistant professor, Universidad Autonoma de Queretaro School of Dentistry, Queretaro, Mexico. + + + + Tsujimoto + A + A + + Akimasa Tsujimoto, DDS, PhD, associate professor, University of Iowa College of Dentistry, Iowa City, IA, USA. + + + + eng + + Journal Article + + + 2023 + 03 + 10 + +
+ + United States + Oper Dent + 7605679 + 0361-7734 + +
+ + + + 2022 + 05 + 26 + + + 2023 + 3 + 14 + 13 + 53 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + aheadofprint + + 36917631 + 491444 + 10.2341/22-033-S + + +
+ + + 36917630 + + 2023 + 03 + 14 + +
+ + 1937-335X + + 29 + 5-6 + + 2023 + Mar + + + Tissue engineering. Part A + Tissue Eng Part A + + 2023 Lifetime Achievement Award of Tissue Engineering and Regenerative Medicine International Society-Americas: Kyriacos A. Athanasiou, PhD. + + 185-186 + + 10.1089/ten.tea.2023.29040.kaa + + + Athanasiou + Kyriacos A + KA + + Department of Biomedical Engineering, Samueli School of Engineering, University of California, Irvine, Irvine, California, USA. + + + + eng + + Journal Article + +
+ + United States + Tissue Eng Part A + 101466659 + 1937-3341 + + IM +
+ + + + 2023 + 3 + 14 + 13 + 53 + + + 2023 + 3 + 15 + 6 + 0 + + + 2023 + 3 + 15 + 6 + 0 + + + ppublish + + 36917630 + 10.1089/ten.tea.2023.29040.kaa + + +
+ + + 36917632 + + 2023 + 03 + 14 + +
+ + 1520-6882 + + + 2023 + Mar + 14 + + + Analytical chemistry + Anal Chem + + Constructing a Myxobacterial Natural Product Database to Facilitate NMR-Based Metabolomics Bioprospecting of Myxobacteria. + 10.1021/acs.analchem.2c05145 + + Myxobacteria are fascinating prokaryotes featuring a potent capacity for producing a wealth of bioactive molecules with intricate chemical topology as well as intriguing enzymology, and thus it is critical to developing an efficient pipeline for bioprospecting. Herein, we construct the database MyxoDB, the first public compendium solely dedicated to myxobacteria, which enabled us to provide an overview of the structural diversity and taxonomic distribution of known myxobacterial natural products. Moreover, we demonstrated that the cutting-edge NMR-based metabolomics was effective to differentiate the biosynthetic priority of myxobacteria, whereby MyxoDB could greatly streamline the dereplication of multifarious known compounds and accordingly speed up the discovery of new compounds. This led to the rapid identification of a class of linear di-lipopeptides (archangimins) and a rare rearranged sterol (corasterol) that were endowed with unique chemical architectures and/or biosynthetic enzymology. We also showcased that NMR-based metabolomics, MyxoDB, and genomics can also work concertedly to accelerate the targeted discovery of a polyketidic compound pyxipyrrolone C. All in all, this study sets the stage for the discovery of many more novel natural products from underexplored myxobacterial resources. + + + + Wang + De-Gao + DG + + State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Shandong University, Qingdao 266237, China. + + + + Wang + Chao-Yi + CY + + State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Shandong University, Qingdao 266237, China. + + + + Hu + Jia-Qi + JQ + + State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Shandong University, Qingdao 266237, China. + + + + Wang + Jing-Jing + JJ + + State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Shandong University, Qingdao 266237, China. + + + + Liu + Wen-Chao + WC + + State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Shandong University, Qingdao 266237, China. + + + + Zhang + Wen-Juan + WJ + + State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Shandong University, Qingdao 266237, China. + + + + Du + Xin-Ran + XR + + State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Shandong University, Qingdao 266237, China. + + + + Wang + Han + H + + State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Shandong University, Qingdao 266237, China. + + + + Zhu + Le-Le + LL + + State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Shandong University, Qingdao 266237, China. + + + + Sui + Hai-Yan + HY + + State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Shandong University, Qingdao 266237, China. + + + + Li + Yue-Zhong + YZ + 0000-0001-8336-6638 + + State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Shandong University, Qingdao 266237, China. + + + + Wu + Changsheng + C + 0000-0003-1310-0089 + + State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Shandong University, Qingdao 266237, China. + + + + eng + + Journal Article + + + 2023 + 03 + 14 + +
+ + United States + Anal Chem + 0370536 + 0003-2700 + + IM +
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+
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