palpitations; itchy; Like a tingling; edema; energy started dipping/brain fatigue; Vaccination site redness; swelling and redness in the injection site; joint-pain (shoulder, hips); strong chills; temperature started climbing to fever/temperature went up to a 102°F; headache; started to have some aches/Very achy (right arm, lesser in the leg); Brain fatigue; pain; This spontaneous case was reported by a consumer and describes the occurrence of OEDEMA (edema), ASTHENIA (energy started dipping/brain fatigue), PARAESTHESIA (Like a tingling), PALPITATIONS (palpitations) and PAIN IN EXTREMITY (started to have some aches/Very achy (right arm, lesser in the leg)) in a 55-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 028L20A, 039K20A and 040L21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     The medical history was not provided by the reporter.  Concomitant products included ANASTROZOLE (ARIMIDEX) for an unknown indication.   On 12-Jan-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 11-Feb-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. In March 2021, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 100 ml. On 11-Feb-2021, the patient experienced OEDEMA (edema), ASTHENIA (energy started dipping/brain fatigue), PAIN IN EXTREMITY (started to have some aches/Very achy (right arm, lesser in the leg)), MENTAL FATIGUE (Brain fatigue), PAIN (pain), VACCINATION SITE ERYTHEMA (Vaccination site redness), VACCINATION SITE SWELLING (swelling and redness in the injection site), ARTHRALGIA (joint-pain (shoulder, hips)), CHILLS (strong chills), PYREXIA (temperature started climbing to fever/temperature went up to a 102°F) and HEADACHE (headache). On 17-Feb-2021, the patient experienced PARAESTHESIA (Like a tingling) and PRURITUS (itchy). In March 2021, the patient experienced PALPITATIONS (palpitations). The patient was treated with PARACETAMOL (TYLENOL) for Pyrexia, at an unspecified dose and frequency. On 13-Feb-2021, OEDEMA (edema), ASTHENIA (energy started dipping/brain fatigue), PAIN IN EXTREMITY (started to have some aches/Very achy (right arm, lesser in the leg)), MENTAL FATIGUE (Brain fatigue), PAIN (pain), ARTHRALGIA (joint-pain (shoulder, hips)), CHILLS (strong chills), PYREXIA (temperature started climbing to fever/temperature went up to a 102°F) and HEADACHE (headache) had resolved. On 17-Feb-2021, VACCINATION SITE ERYTHEMA (Vaccination site redness) and VACCINATION SITE SWELLING (swelling and redness in the injection site) had resolved. On 20-Feb-2021, PARAESTHESIA (Like a tingling) and PRURITUS (itchy) had resolved. At the time of the report, PALPITATIONS (palpitations) outcome was unknown.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On an unknown date, Alanine aminotransferase: high (High) High. On an unknown date, Aspartate aminotransferase: high (High) High. On an unknown date, Blood pressure measurement: 137/99 mmHg (High) pressure went up to 137 over 99 after about 30 minutes. On an unknown date, Blood test: abnormal (abnormal) abnormal. On an unknown date, Body temperature: 102 (High) 102°F. On an unknown date, Prealbumin: high (High) high. On an unknown date, Vitamin D: 18 (Low) 18.         Patient also reported that the third dose given was of 100ml instead of 50ml, the lot of this shot is 040L21A.  Patient stated that her doctor advised to  take Benadryl 24 hours before the vaccine.   This case was linked to MOD21-022141 (Patient Link).