mild headache; fever; fatigue; lymph node that is swollen; chills; brain fog; irritability; dizziness; very itchy; an oval shape rash; Mood change; dark border it might be a fungus; low levels of B-12; lump on the right side of his neck; Inflammed lymph node; This non-serious case was reported by a consumer via call center representative and described the occurrence of headache in a 63-year-old male patient who received Herpes zoster (Shingrix) for prophylaxis.   Co-suspect products included PNEUMOCOCCAL VACCINE POLYSACCHARIDE 23 VALENT (PNEUMOVAX) for prophylaxis.   Family history included cancer.   On 23-JUN-2023, the patient received the 2nd dose of Shingrix (intramuscular, left arm) and PNEUMOVAX (right arm). In JUN-2023, 4 days after receiving Shingrix, the patient experienced lymph node inflammation (Verbatim: Inflammed lymph node). On 26-JUN-2023, the patient experienced local swelling (Verbatim: lump on the right side of his neck). On an unknown date, the patient experienced headache (Verbatim: mild headache), fever (Verbatim: fever), fatigue (Verbatim: fatigue), swollen lymph nodes (Verbatim: lymph node that is swollen), chills (Verbatim: chills), brain fog (Verbatim: brain fog), irritability (Verbatim: irritability), dizziness (Verbatim: dizziness), pruritus (Verbatim: very itchy), rash (Verbatim: an oval shape rash), mood change (Verbatim: Mood change), fungal infection (Verbatim: dark border it might be a fungus) and vitamin b12 decreased (Verbatim: low levels of B-12). The patient was treated with clotrimazole (Lotrimin Cream), paracetamol (Tylenol), vitamin B substances nos (B-Complex) and non-drug therapy (Warm Compresses). The outcome of the headache, fever, chills, brain fog and dizziness were resolved and the outcome of the fatigue, swollen lymph nodes, pruritus and rash were not resolved and the outcome of the irritability and vitamin b12 decreased were unknown and the outcome of the lymph node inflammation, mood change, fungal infection and local swelling were not reported.   It was unknown if the reporter considered the headache, fever, fatigue, swollen lymph nodes, chills, brain fog, irritability, dizziness, pruritus, rash, lymph node inflammation, mood change, fungal infection, local swelling and vitamin b12 decreased to be related to Shingrix.     It was unknown if the company considered the headache, fever, fatigue, swollen lymph nodes, chills, brain fog, irritability, dizziness, pruritus, rash, lymph node inflammation, mood change, fungal infection, local swelling and vitamin b12 decreased to be related to Shingrix.   Additional Information: GSK Receipt Date: 31-JUL-2023 The reporter was the spouse of a patient who received the 2nd dose of Shingrix and Pneumovax vaccine.  The reporter stated that 3 days later the patient showed a lump on the right side of his neck. The patient had fatigue, fever, brain fog, chills, mild headache, dizziness, and mood changes of irritability. Four days after the vaccine he developed an inflamed lymph node, 3 inches below the left armpit there was a lymph node that was inflamed and swollen. The size of the inflammation under the arm was like a baseball. The reporter stated that the patient applied warm compresses and it was decreased the inflammation, but it came back, the patient had Tylenol for this.   From the left side of the back patient had an oval shape rash that had spread now to the right side of the front area and had a darker border. It had spread to the upper chest, and it was very itchy, Healthcare professional saw photos of the rash and stated because of the dark border it might be a fungus. Customer reported that patient was using a Lotrimin cream (clotrimazole) but it was not helping. The patient had a blood lab done and a test called CRP:  C reactive protein, it was an inflammatory marker, and the result was for 17, it was increased to 20.6.  The lab test result showed low levels of B-12 and patient was recommended a B-Complex. It was unknown if the reporter considered the adverse events to be related to Pneumovax. The reporter consented to follow up.