Associated with this leg swelling is pain that was intolerable; The patient couldn't walk, had to crawl, couldn't drive, couldn't pick up her grandkids, or take care of her self; It felt like shards of glass in all of her bursae in her knees and that's why she couldn't put any weight on them; stroke; swelling in the legs; inflammation in the bursa on both knees; felt woozy; headachy; felt not so wonderful; couldn't multi-task thought; right eye split opened; brain freeze; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP) from medical information team. The reporter is the patient.  A 68 year-old female patient received bnt162b2 (BNT162B2), administered in arm left, administration date 03Apr2021 (Lot number: ER8727) at the age of 68 years as dose 2, single for covid-19 immunisation. The caller has map dystrophy and was diagnosed with that 35 years ago when she was pregnant. The patient had no relevant medical history. Concomitant medication(s) included: SYNTHROID; METFORMIN. Vaccination history included: Bnt162b2 (First Dose, Lot: EN6206, expiration: 30Jun2021, Anatomical location: left arm), administration date: 10Mar2021, when the patient was 67 years old, for Covid-19 Immunization. The following information was reported: CEREBROVASCULAR ACCIDENT (medically significant) with onset 13Jun2021, outcome "not recovered", described as "stroke"; PERIPHERAL SWELLING (non-serious) with onset 13Jun2021, outcome "recovering", described as "swelling in the legs"; ARTHRITIS (non-serious) with onset 13Jun2021, outcome "recovering", described as "inflammation in the bursa on both knees"; DIZZINESS (non-serious) with onset 13Jun2021, outcome "recovered" (2021), described as "felt woozy"; HEADACHE (non-serious) with onset 13Jun2021, outcome "recovered" (2021), described as "headachy"; FEELING ABNORMAL (non-serious) with onset 13Jun2021, outcome "recovered" (2021), described as "felt not so wonderful"; THINKING ABNORMAL (non-serious) with onset 13Jun2021, outcome "recovered" (2021), described as "couldn't multi-task thought"; EYE DISORDER (non-serious) with onset 13Jun2021, outcome "unknown", described as "right eye split opened"; COLD-STIMULUS HEADACHE (non-serious) with onset 13Jun2021, outcome "not recovered", described as "brain freeze"; PAIN (non-serious), outcome "unknown", described as "Associated with this leg swelling is pain that was intolerable"; GAIT INABILITY (non-serious), outcome "unknown", described as "The patient couldn't walk, had to crawl, couldn't drive, couldn't pick up her grandkids, or take care of her self"; MUSCULOSKELETAL DISCOMFORT (non-serious), outcome "unknown", described as "It felt like shards of glass in all of her bursae in her knees and that's why she couldn't put any weight on them". The events "stroke", "swelling in the legs", "inflammation in the bursa on both knees", "felt woozy", "headachy", "felt not so wonderful", "couldn't multi-task thought", "right eye split opened" and "brain freeze" were evaluated at the emergency room visit. The patient underwent the following laboratory tests and procedures: blood test: (2021) perfect, notes: had 7-8 vials of blood drawn at each office and all of it was clean; ultrasound doppler: (2021) unknown results, notes: primary care provider took dopplers because he thought she was having a stroke; x-ray: (04Jul2021) there was nothing, notes: They did an x-ray on the caller's knee at that time. Therapeutic measures were taken as a result of cerebrovascular accident.Reporter reported that after the 2nd dose about 6 to 8 weeks later, the patient experienced swelling in the legs where she had inflammation in the bursa on both knees. Agent states that after the patient received her booster, the inflammation started in the elbow. patient states her head has not felt right since as she can not multitask and has had headaches. Agent states that the patient's daughter also had a reaction after receiving the vaccine but did not file a safety report, patient did not provide any additional information regarding her daughters AE throughout the call. patient would like to know if this side effect has been reported. she was scared that the inflammation will come back, but she states she thinks the inflammation was less of a degree since months had passed between the second and third dose. patient states she has a feeling many people have not reported this side effect like herself. patient states she is not too worried right now as long as it was manageable. The patient received her second dose in the first week of Apr2021. After that the patient felt woozy, headachy, felt not so wonderful for a week or 2 and sometimes couldn't multi-task thought it would go away. On 13Jun2021 the patient went to her friend's wedding and she walked up the stairs, had a good time, ate, and danced. The patient started feeling odd and went to the bathroom and she couldn't get her pants off because her legs had swollen twice the size. The patient and the doctors thought there was something wrong. They did dopplers and x-rays on the patient and they said other things were wrong. Associated with this leg swelling is pain that was intolerable. The patient couldn't walk, had to crawl, couldn't drive, couldn't pick up her grandkids, or take care of her self. On 04Jul2021 the patient ended up in the hospital because her daughter and her husband didn't know what else to do with her. The patient was seen at an orthopedist and they thought it was arthritis. The patient knew it wasn't arthritis because it came on in 3 hours. At this time the caller was walking with a cane, couldn't move her legs, and had to crawl up and down. There were more adverse events than the patient cares to think about. The patient finally she got to see the rheumatologist. The rheumatologist said the patient has inflammation but no arthritis in her joints or knees. It felt like shards of glass in all of her bursae in her knees and that's why she couldn't put any weight on them. This lasted all the way to Sep and it started to go away. Then it attacked her middle of Nov. The rheumatologist prescribed a strong medication and she took that for 2 weeks and it cut the inflammation that was starting up again. The patient got better and is back on the treadmill but only doing 30 minutes, not the 40 minutes that was her baseline, because her legs atrophied at this point. The caller went to the second rheumatologist and he was the top guy at a very good hospital, one of the best in (withheld). The rheumatologist spent 2 hours with the caller and he said he has seen this before and it hits 6-8 hours after the second dose. The vaccine created massive inflammation in the caller, in her case it was her knees. The patient did not want to take the booster but he recommended it because if she got covid God only knows what the results will be. The patient took the booster and has not had a clear head or non headache day since the end of Dec when she took it. The caller does not feel well, she had palpitations, her elbow was inflamed. Because the patient elbow hurt she was put on a round of steroids to try to prevent this, she now has been weaned off. If it comes back she will be put on stronger and longer steroids. The patient was not happy, she understands we should protect ourselves but people should know this can happen. The patient primary care provider took dopplers because he thought she was having a stroke. Today the caller was going to start taking an Aspirin every day so that she does not had a stroke. The caller gets a brain freeze and was very uncomfortable. The last doctor had seen this before and the caller thought she was losing it, the orthopedist also thought it was in the caller's head. Now the caller is off the steroids and there is inflammation in her elbow. After the third dose the patient head was not her self. The patient got really sick after the booster and wasn't feeling well. After a day or so the patient was started on the steroids and she does not feel right and this was not her normal. The patient elbow worsened after the steroids were taken away, as she was titrating down she was feeling it and its there. Methylprednisolone- lot and NDC unknown, expiration date 21Dec2022. The product is in a pharmacy bottle and the print is so tiny. After the second dose of the Pfizer covid vaccine, the patient right eye split opened. At first it was the patient legs and then this was a inflammatory condition went to her right eye. The patient ended up at a specialist and the top corneal specialist worked with her and told her to give it time and it avoided surgery. The patient had gotten back most of the vision, 95% of it. The vaccine creates inflammation in the body, it effected her in two different areas and now the third area. The patient clarifies that she was only seen in the emergency room on 04Jul2021 and was never admitted as a patient into the hospital. They did an x-ray on the caller's knee at that time. Investigations: The caller's doppler was done prior to her going to the emergency room. The caller has had 7-8 vials of blood drawn at each office and all of it was clean.Other products reported as yes. Investigation assessment was reported as yes. Patient was seen 4-5 doctors. patient hormones were changing she would lose her sight and there's no pain killers for that. After the second dose of the Pfizer covid vaccine, the caller's right eye split opened.  No follow-up attempts are possible. No further information is expected.; Sender's Comments: Linked Report(s) : US-PFIZER INC-202200038504 Same reporter/patient, different dose number and similar event