There has been a gradual improvement in her cognitive skills; there's something in vaccine that's helping wife Alzheimers; This is a spontaneous report from a contactable consumer reported for wife from a Pfizer-sponsored program. A 74-years-old female patient received BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE; Solution for injection; Lot Number: EL3247; Expiration date was not reported), via an unspecified route of administration, administered in Arm Left on 18Jan2021 as DOSE 1, SINGLE for covid-19 immunisation as the doctor recommended to get it. Medical history included stomach pains from Jan2020 to an unknown date, stomach bloated up huge from Jan2020 to an unknown date, entire colon removed except the last 30 cm from Sep2020 to an unknown date, bladder from an unknown date and unknown if ongoing, low thyroid from an unknown date and unknown if ongoing, anxiety from an unknown date and unknown if ongoing, Alzheimer from Apr2018 and ongoing, started panicking from Apr2018 to an unknown date, bizarre from Apr2018 to an unknown date. Concomitant medication(s) included solifenacin (SOLIFENACIN) taken for bladder disorder; levothyroxine (LEVOTHYROXINE) taken for thyroid disorder; potassium chloride (POTASSIUM CHLORIDE) taken for an unspecified indication; clonazepam (CLONAZEPAM) taken for anxiety from an unspecified start date and ongoing. The patient previously took memantine (MEMANTINE) for Alzheimer and experienced colon injury. The patient experienced there has been a gradual improvement in her cognitive skills, there was something in vaccine that was helping wife Alzheimer's on an unspecified date. No patient identifiers were provided but the reporter had first-hand knowledge of the patient and was reporting on a specific patient. Patient had Alzheimer was very bad, has had it for years and keeps getting worse. However, couple days after 1st dose caller noticed some cognitive improvements. After 2nd dose of vaccine patient keeps making small progress. Over weekend was able to feed herself, making small decisions on her own. Things she hadn't done in years. Caller thinking there was something in vaccine that was helping wife Alzheimer's. In Jan2020 she all of a sudden started having stomach pains. It escalated with her GI tract. Her stomach bloated up huge. It looked like someone had put a basketball in there. The GI doctors didn't know what it was. Their son happened to know an international GI endoscopic professor who saw her. She has had the entire colon removed except the last 30cm. The surgery was Sep2020. Hopefully this is a positive side effect. His wife was diagnosed with Alzheimer in Apr2018. At the last meeting with the neurologist, the neurologist was concerned about her decline. That was 5 to 6 weeks ago. Had first Pfizer COVID vaccination. Reporter was his wife's caregiver. He noticed a few things she was doing, and it got his curiosity up. There had been a gradual improvement in her cognitive skills. She seemed to be more apparent of her surroundings. She seemed to be comprehending tv shows and was laughing and understanding. She was talking in longer sentences. She has said 4-to-6-word sentences and once a 9-word sentence. Prior to the vaccine, if he asked her question she would grunt yes or no. Her sense of humor was increasing. She was beginning to putter around the house. She used to be a good housekeeper and he tries to keep that up, but she was starting to do more with her hands. She was tearing up napkins into square pieces. She was not back to coloring like she used to. What really made him want to call was because she fed herself three meals over the weekend. She had not done that in the past year and a half. Every now and then she would pick up her spoon or fork three or four times during a meal, but that was the extent before the vaccines. Patient weight was 106 to 107 pounds. Reporter spoke to his wife's family doctor about this. Her neurologist is (Name). The last time he saw reporter's wife he was concerned about the decline. She would just sit in the chair. That was five or six weeks ago. Reporter did send email to see if any there were any other reports, but he has not heard back. The first dose was three weeks before on 18Jan2021 in upper left arm and three days later was when he started noticing things. He would say about the twentieth or twenty first was when he started noticing things. It had been gradual. Little changes over different days. Nothing extreme. The other thing she did that was astounding to him was she walked up to him and said, "Are you ok?" Then she said, "Just checking on you." That astounded him. She had been cool calm and collective her whole life. In Apr2018 she started panicking. It was bizarre. She thought someone had murdered their neighbour and was after them. Their lives changed in a snap in Apr2018. She had a hard time last year. She was diagnosed with Alzheimer's in Apr2018. No further details provided. Additional vaccines administered on same date of the Pfizer suspect; prior vaccinations (within 4 weeks) included none. It would be a wild deal if the COVID vaccine helped Alzheimer's. Clinical outcome of event was unknown.  Follow-up attempts are completed. No further information is expected.