Musculoskeletal disorder; lost seven pounds; Cramping in finger; Mobility decreased; Stiffness; Chills; Joint pain; Difficulty in walking; fingers became swollen; down for three days for vomiting; This spontaneous case was reported by a consumer and describes the occurrence of MUSCULOSKELETAL DISORDER (Musculoskeletal disorder), WEIGHT DECREASED (lost seven pounds), GAIT DISTURBANCE (Difficulty in walking), PERIPHERAL SWELLING (fingers became swollen) and MUSCLE SPASMS (Cramping in finger) in a 50-year-old male patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.    Co-suspect products included non-company products UPADACITINIB (RINVOQ) for Rheumatoid arthritis and ADALIMUMAB (HUMIRA) for an unknown indication.    No Medical History information was reported.   On an unknown date, the patient received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form On an unknown date, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form and first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form., UPADACITINIB (RINVOQ) (Oral) at an unspecified dose and ADALIMUMAB (HUMIRA) (Subcutaneous) at an unspecified dose. In May 2021, the patient experienced GAIT DISTURBANCE (Difficulty in walking), PERIPHERAL SWELLING (fingers became swollen) and ARTHRALGIA (Joint pain). On an unknown date, the patient experienced MUSCULOSKELETAL DISORDER (Musculoskeletal disorder), WEIGHT DECREASED (lost seven pounds), MUSCLE SPASMS (Cramping in finger), MOBILITY DECREASED (Mobility decreased), MUSCULOSKELETAL STIFFNESS (Stiffness), VOMITING (down for three days for vomiting) and CHILLS (Chills). At the time of the report, MUSCULOSKELETAL DISORDER (Musculoskeletal disorder) and WEIGHT DECREASED (lost seven pounds) outcome was unknown, GAIT DISTURBANCE (Difficulty in walking), PERIPHERAL SWELLING (fingers became swollen), MUSCLE SPASMS (Cramping in finger) and ARTHRALGIA (Joint pain) was resolving and MOBILITY DECREASED (Mobility decreased), MUSCULOSKELETAL STIFFNESS (Stiffness), VOMITING (down for three days for vomiting) and CHILLS (Chills) had resolved.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On an unknown date, Weight: Lost seven pounds.         Concomitant drugs were not reported.  The Humira worked for first 3 months.  The patient also had cramping in finger. He had spent a lot of time on his feet and his right foot was especially affected. After taking the COVID booster, he was down for three days for vomiting and lost seven pounds because, he could not keep any food down. He also had chills.  The reporter's causality for the events of fingers swelling, fingers cramping and Humira worked for first three months with RINVOQ(Upadacitinib) was a reasonable possibility.  Treatment medications were not provided.  It was unknown if patient was enrolled in a COVID-19 Vaccine Trial.   This case was identified as part of retrospective clean-up activity where certain emails received in the Moderna mailbox were missed to be booked-in