COVID-19 vaccine: it has almost cured her diabetes; but her blood sugars have been low to normal sugars; This is a spontaneous report from a contactable consumer (Patient). A 73-year-old female patient received bnt162b2 (BNT162B2 (PFIZER-BIONTECH COVID-19 mRNA VACCINE, solution for injection, Batch/Lot Number: EN6206) dose 2 via an unspecified route of administration, administered in left arm on 17Mar2021 at 13:00 as dose 2, single for COVID-19 immunisation; metformin (METFORMIN), oral from Apr2021 (Batch/Lot number was not reported, NDC number of Metformin: 62756-0142-02) to an unspecified date, at 500 mg extended release up to two tablets by mouth with breakfast and dinner for diabetes mellitus; pioglitazone (PIOGLITAZONE), oral from an unspecified date (Batch/Lot number was not reported, NDC number of Pioglitazone: 57237-022-90) to an unspecified date, at 30 mg, 1 per day (30mg every morning by mouth) for diabetes mellitus; glimepiride (GLIMEPIRIDE), route of administration, start and stop date, batch/lot number and dose were not reported for diabetes mellitus. Medical history included diabetes mellitus and was diagnosed about 20 years ago, blood pressure high and was diagnosed about 17 years ago, diastolic dysfunction (she has a couple leaky valves and it is not bad), left bundle branch block and was diagnosed about 17 years ago. The concomitant medications were not reported. The patient did not had any other recent vaccinations in the last four weeks or with or before getting the two vaccine doses. She also has not started any new medications. The patient previously received first dose of BNT162B2 on 24Feb2021 (lot: EMA809, left arm) at 11:00 AM for covid-19 immunisation. Reason for no lot number of Metformin and Pioglitazone was reported as product dispensed in pharmacy via and the reason for no lot number of glimepiride was reported as complainant does not have the product with them at the time of call. On Mar2021 the patient experienced received COVID-19 vaccine and it has almost cured her diabetes. On 2021 the patient experienced her blood sugars have been low to normal sugars. The patient reported that she took the Pfizer COVID-19 vaccine and had both shots, and she did not have trouble with either of them. The patient reported that it had almost cured her diabetes, and she does not know what messenger RNA does, but her blood sugars have been low to normal sugars. The patient has had diabetes for 20 years and her blood sugars were always high. The patient reported that they have been in the 120s in the mornings. The patient says she had been taking 6 pills a day for a long time, and she is down right now to taking two maybe today. The patient woke up the last few mornings and her blood sugars were 127 and 137, they have never been that low in the mornings. The patient normally takes Glimepiride, which lowers her sugar real quick, and her sugar is usually 200 something, but she has not taken this medication in two weeks or more, because the last time she did it bottomed her sugar and she had eaten. The patient says getting old is no fun. The patient underwent lab tests and procedures which included blood glucose: 127 mg/dl, 137 mg/dl, 200 mg/dl and blood glucose decreased. The action taken in response to the events with metformin, pioglitazone and glimepiride was unknown. The patient had not taken Glimepiride in two weeks or more in Mar2021 and reported that her Glimepiride bottomed her sugar from unspecified date to unspecified date. The outcome of events was reported as unknown. No follow-up attempts are possible. No further information is expected.