This case was reported by a nurse via other manufacturer and described the occurrence of vaccination failure in a 81-year-old female patient who received Flu unspecified (Flu vaccine) for prophylaxis. Previously administered products included Shingles vaccine (received in 2014 and had mild case of shingles 2 to 3 weeks later of shingles vaccination). Concurrent medical conditions included thyroid hormones decreased, blood cholesterol increased, atrial tachycardia (From 2015), latex allergy (since 1980's), allergy to plants (Psyllium allergy, the patient had an anaphylactic reaction to a metapower bar in 2015. About 7 minutes after eating the bar, she went into a severe reaction and ended up in the emergency room and stayed overnight.) and fruit allergy (Banana, avocado, and kiwi allergy and the patient stated all were interrelated because they were cousins to the rubber tree plant and also healthcare personnel allergic to latex could and might develop a cross allergy to psyllium which was Metamucil). Concomitant products included levothyroxine sodium (Synthroid), calcium + magnesium (Calcium With Magnesium), chondroitin + glucosamine (Glucosamine Chondroitin) and vitamins nos (Multivitamin). On an unknown date, the patient received Flu vaccine. On an unknown date, unknown after receiving Flu vaccine, the patient experienced vaccination failure (serious criteria GSK medically significant), macular degeneration (serious criteria GSK medically significant), influenza and atrial tachycardia. The patient was treated with ascorbic acid + copper + retinol + tocopherol + zinc (Ocuvite Preservision) and ascorbic acid (Vitamin C). On an unknown date, the outcome of the vaccination failure, macular degeneration, influenza and atrial tachycardia were unknown. It was unknown if the reporter considered the vaccination failure, macular degeneration, influenza and atrial tachycardia to be related to Flu vaccine. Additional details were reported as follows: The registered nurse reported this case for herself. The age at vaccination was not reported. The patient was taking Multivitamin (unspecified) since 1995 or 1996, about 25 years for general health and glucosamine chondroitin since late 1990s, about 20 years for joint health. The patient started Synthroid about 15 years ago and taking Calcium with Magnesium as it had calcium citrate from a long time, 5 to 10 years, she did not really remember the exact date. In 2015, the patient received flu vaccine and got the flu. The patient was diagnosed with macular degeneration (age related) about 3 to 5 years ago from reporting date and the physician prescribed Ocuvite PreserVision along with Vitamin C as eye doctor thought it was a good idea to take together and the patient was taking there for about 3 years and stated macular degeneration had not changed or gotten worse in 3 years. The patient stated that she would had lost her job if she did not take vaccine. It had been 5 to 10 years before that, and another 5 to 10 years before that.  The patient stated she stays away from the flu shot. The patient stated she did not have an email and was computer illiterate. The reporter and Primary Care HCP (health care professional) consented to follow-up. This case was considered as suspected vaccination failure as details regarding time to onset and laboratory test confirming herpes zoster were unknown at the time of reporting. For tolerance of Valacyclovir refer case US2021AMR116456, reported by same reporter. This case has been linked with US2021AMR116396 by same patient.