This spontaneous report was received from a medical assistant refers to a 65 year old non-pregnant female patient. The patient's concurrent conditions included hyperlipidemia, vertigo, vitamin D deficiency, Sjogren's syndrome, paroxysmal supraventricular tachycardia, chronic lymphocytic leukaemia, osteoporosis, carpal tunnel syndrome of left wrist, non-smoker, non-alcoholic and caffeine user (1-2 cups per day). The patient's historical conditions included implantable defibrillator insertion on 24-MAY-2011, cardiac pacemaker insertion on 24-MAY-2011, hyperplaplastic polyps, diverticulae, laparoscopic hysterectomy on 04-JAN-1995, Laparoscopic gallbaladder surgery on 23-MAR-2001, abdominal surgery on 09-MAY-2001, fibroids, gravida 1 and para 1. Pap smear was performed to the patient which resulted partial hyst fue to fibroids, mammogram and colonoscopy with normal results, endoscopy (results not provided), dexa bone density was done on an unknown date in March 2012, with the abnormalities included previous osteoporosals and treated with Acton (taken off since 2011), nuclear stress test and echocardiogram with normal results. The patient's family history included maternal grandfather and maternal aunt had colon cancer and The patient's historical drugs included tetanus vaccine, pravastatin, ciprofloxacin hydrochloride, sulfa drugs which caused swelling, cottonseed oil which caused hives, fluticasone which caused chills, fever and hives, KEFLEX which caused hives, iodine which caused blisters on her hand, iodinated glycerol which caused blisters, penicillins which caused hives in mouth and LEVAQUIN which caused swelling of tongue and sores on throat. The patient's concomitant medications included RESTASIS, SYSTANE, cod liver oil, multivitamins, omega-3 marine triglycerides, sotalol hydrochloride, vitamin B complex, fluticasone propionate, VALTREX, ALLEGRA and FLAGYL. On 23-MAR-2018, the patient was vaccinated with ZOSTAVAX (dose, units and frequency not reported) (lot# N032103 and expiration date: 11-FEB-2019) subcutaneously for prophylaxis of shingles. Since on an unknown date patient had itching and rash appeared on 06-APR-2018 with erythema with vesicles. It was reported that, lesions were separate at first and then became more confluent. The patient was diagnosed with shingles on her arm. Patient's vital signs included temperature was 97.8 Ffahrenheit, heart rate was 88, blood pressure was 130/80 mmhg, weight was 80.34 kilograms, body mass index was 29.93, height was 64.5 inches and oxygen saturation was 96%. General examination included no acute distress, well developed and well nourished. Dermatology revealed c7 dermatome on upper arm with vesicular rash and erythema. The patient sought medical attention and was treated with topical lidocaine culture-prep alcohol and sterile needle used to poke a hole in vesicle to obtain specimen and place in sterile cup and sample sent to manufacturer. The patient was also treated with gabapentin capsule 100 mg, orally for 30 days. On an unknown date in April 2018, it was reported that, the patient's rash was not just on her arm and it was moved to the ankles. The patient was treated with valacyclovir and shingles was spreading (disease progression). The outcome of the events was not recovered. The reporter assessed that there was related causal relationship for the events shingles and vaccination site reaction with suspect therapy ZOSTAVAX. The reporter did not provide the causal relationship for the event disease progression with suspect therapy ZOSTAVAX. No product quality complaint was involved. Lot number [N032103] has been verified to be a valid lot number for [ZOSTAVAX].