Extremely itchy/down her right arm, chest, and back/ generalized Itching/pruritus; Hives, itching, moving all over body/has little hives/Hives on back of neck and into hairline; idiopathic urticaria; Developed lymph nodes on booster arm/Lymph node swelling armpit and breast; Soreness in arm; This spontaneous case was reported by an other health care professional and describes the occurrence of PRURITUS (Extremely itchy/down her right arm, chest, and back/ generalized Itching/pruritus), MYALGIA (Soreness in arm), URTICARIA (Hives, itching, moving all over body/has little hives/Hives on back of neck and into hairline), VACCINATION SITE LYMPHADENOPATHY (Developed lymph nodes on booster arm/Lymph node swelling armpit and breast) and IDIOPATHIC URTICARIA (idiopathic urticaria) in a 34-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 029L20A and 026L20A) for COVID-19 vaccination.     The patient's past medical history included Kidney stones on 06-Sep-2021. Concurrent medical conditions included Mite allergy (allergic to dust mites, hive itching - during allergy testing) since 04-Dec-2020.   On 28-Dec-2020 at 4:00 PM, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 25-Jan-2021 at 4:00 PM, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 01-Nov-2021, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 15-Nov-2021, the patient experienced PRURITUS (Extremely itchy/down her right arm, chest, and back/ generalized Itching/pruritus), URTICARIA (Hives, itching, moving all over body/has little hives/Hives on back of neck and into hairline) and IDIOPATHIC URTICARIA (idiopathic urticaria). In November 2021, the patient experienced MYALGIA (Soreness in arm) and VACCINATION SITE LYMPHADENOPATHY (Developed lymph nodes on booster arm/Lymph node swelling armpit and breast). The patient was treated with FEXOFENADINE HYDROCHLORIDE (ALLEGRA [FEXOFENADINE HYDROCHLORIDE]) at a dose of UNK UNK, bid and CETIRIZINE HYDROCHLORIDE (CETRIZINE) at an unspecified dose and frequency. At the time of the report, PRURITUS (Extremely itchy/down her right arm, chest, and back/ generalized Itching/pruritus) and IDIOPATHIC URTICARIA (idiopathic urticaria) had not resolved, MYALGIA (Soreness in arm) and VACCINATION SITE LYMPHADENOPATHY (Developed lymph nodes on booster arm/Lymph node swelling armpit and breast) outcome was unknown and URTICARIA (Hives, itching, moving all over body/has little hives/Hives on back of neck and into hairline) was resolving.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On 11-Nov-2021, Blood pressure measurement: high (High) 134/86 mmHg. On 11-Nov-2021, Body temperature: high (High) 99 F. On 11-Nov-2021, Heart rate: normal (normal) 87 Beats/min.     For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown), the reporter did not provide any causality assessments.   No concomitant medication information was provided.  Adverse events occurred 2 weeks after receiving the 3rd dose of Moderna. Hives/itching/streaking marks come Patient had generalized uncontrollable itching/ pruritus, generalized redness/ erythema, generalized  rash, generalized  hives/urticaria, flushing and streak like markings.  Adverse events occured 2 weeks after receiving the 3rd dose of Moderna. Hives/itching/streaking marks come and go. Since starting on the double dose of antihistamine patient had noticed some improvement.   This case was linked to MOD-2021-403010, MOD-2021-403012 (Patient Link).   Most recent FOLLOW-UP information incorporated above includes: On 06-Dec-2021: significant follow up received . Added patient's height, weight, race, ethnicity and medical history. Added treatment medications and additional event.