could not eat properly; lost 15 Ibs; so much constipation; most incredible heartburn; nausea; chills; fever; This spontaneous case was reported by a consumer and describes the occurrence of DECREASED APPETITE (could not eat properly), WEIGHT DECREASED (lost 15 Ibs), CONSTIPATION (so much constipation), DYSPEPSIA (most incredible heartburn) and NAUSEA (nausea) in a 66-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch no. 023M20A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     The patient's past medical history included Clinical trial participant and Pregnancy. Concurrent medical conditions included Acid reflux (esophageal), Rotator cuff injury and Thyroid disorder NOS (under control as patient takes thyroid medicine). Concomitant products included PANTOPRAZOLE for Acid reflux (esophageal), LEVOTHYROXINE SODIUM (SYNTHROID) for Thyroid disorder NOS, ROSUVASTATIN CALCIUM (CRESTOR) and HYDROCHLOROTHIAZIDE, VALSARTAN (VALSARTAN & HCTZ) for an unknown indication.    On 23-Feb-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 23-Feb-2021, the patient experienced CHILLS (chills) and PYREXIA (fever). On 24-Feb-2021, the patient experienced DYSPEPSIA (most incredible heartburn) and NAUSEA (nausea). On an unknown date, the patient experienced DECREASED APPETITE (could not eat properly), WEIGHT DECREASED (lost 15 Ibs) and CONSTIPATION (so much constipation). The patient was treated with ALUMINIUM HYDROXIDE, MAGNESIUM HYDROXIDE, SIMETICONE (MAALOX ADVANCED [ALUMINIUM HYDROXIDE;MAGNESIUM HYDROXIDE;SIMETICONE]) for Adverse event, at an unspecified dose and frequency; OMEPRAZOLE (PRILOSEC [OMEPRAZOLE]) for Heartburn, at an unspecified dose and frequency and Manual therapy (patient had 2 bags of prunes) for Constipation. At the time of the report, DECREASED APPETITE (could not eat properly), WEIGHT DECREASED (lost 15 Ibs), CONSTIPATION (so much constipation), DYSPEPSIA (most incredible heartburn), NAUSEA (nausea), CHILLS (chills) and PYREXIA (fever) outcome was unknown.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On 23-Feb-2021, Body temperature: 100-101 (High) 100-101.     The action taken with mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) was unknown.   For mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular), the reporter did not provide any causality assessments.   Patient was taking pantoprazole for 7 years and had no heartburn.Reported that the heartburn was under control with the medicine.Patient tried ginger and turmeric but reported that they had not helped. Patient's gastroenterologist suggested to double up pantoprazole for 30 days and the patient reported that the heartburn went away. But once she stopped taking doubled pantoprazole, it came back and was pretty bad.Patient participating in a clinical trial for an Alzheimer drug .As she had experienced all these side effects from mRNA vaccine, she was advised not to continue in the trial as the drug also contains ingredients of mRNA   This case was linked to MOD-2021-253209 (Patient Link).   Most recent FOLLOW-UP information incorporated above includes: On 23-Jul-2021: Follow up received contains non-significant information.