Sore throat; night sweats; O2 inconsistent and periods of low O2; COVID-19 treatment; COVID-19 treatment; faintly; This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP). The reporter is the patient.  A 42-year-old female patient (not pregnant) received BNT162b2 (BNT162B2), on 15Feb2021 as dose 1, single (Lot number: EL9264), in left arm, on 08Mar2021 as dose 2, single (Lot number: EN6203), in right arm and on 16Aug2021 as dose 3 (booster), single (Lot number: FA7484) at the age of 41 years, in right arm for covid-19 immunisation; coviD-19 vaccine mrna (mrna 1273) (MODERNA COVID-19 VACCINE), on 03Feb2022 as dose 4 (booster), single (Lot number: A42J21A), in left arm for covid-19 immunisation. The patient's relevant medical history included: "Asthma" (unspecified if ongoing); "ehlers-Danlos" (unspecified if ongoing), notes: ehlers-Danlos; "known allergies: Penicillins" (unspecified if ongoing), notes: known allergies: Penicillins; "Interchange of vaccine products" (unspecified if ongoing), notes: dose numbers (1,2 and 3) Pfizer, dose number 4 moderna. Concomitant medication(s) included: DESLORATADINE; BIOTE HORMONE PELLET THERAPY [TESTOSTERONE]; ZINC; VITAMIN C [ASCORBIC ACID]; VITAMIN D [COLECALCIFEROL]; VITAMIN B6. Past drug history included: Hydrocodone, reaction(s): "known allergies: hydrocodone", notes: known allergies: hydrocodone; Darvacet, reaction(s): "known allergies: Darvacet", notes: known allergies: Darvacet. The following information was reported: VACCINATION FAILURE (medically significant), COVID-19 (medically significant) all with onset 15May2022, outcome "not recovered" and all described as "COVID-19 treatment"; SYNCOPE (medically significant) with onset 15May2022, outcome "not recovered", described as "faintly"; OXYGEN SATURATION DECREASED (non-serious) with onset 16May2022, outcome "not recovered", described as "O2 inconsistent and periods of low O2"; OROPHARYNGEAL PAIN (non-serious) with onset 16May2022, outcome "not recovered", described as "Sore throat"; NIGHT SWEATS (non-serious) with onset 16May2022, outcome "not recovered". The patient underwent the following laboratory tests and procedures: Oxygen saturation: (16May2022) inconsistent and periods of low O2.; (26May2022) 02 fluctuates at times to low 90's.; SARS-CoV-2 test: (15May2022) Positive; (16May2022) Positive, notes: Dark Positive; (22May2022) negative; (23May2022) negative; (26May2022) positive, notes: tested positive again. Therapeutic measures were taken as a result of vaccination failure, covid-19. It was unknown if therapeutic measures were taken as a result of syncope, oropharyngeal pain, night sweats, oxygen saturation decreased.  Clinical course: Reported Event: Tested + 15May2022 faintly. Dark positive 16May2022. Sore throat, night sweats, O2 inconsistent and periods of low O2. Started Paxlovid PM. of 16May2022. By 22May2022 was feeling better and testing negative. 23May2022 still negative. 26May2022 symptoms returned- sore throat, headache and tested positive again. Symptoms worsening gradually. sore throat, headaches, dry cough, 02 fluctuates at times to low 90's. Were you/Was the patient taking any other medications/products within 2 weeks of starting COVID-19 treatment?: Yes. Did you/the patient previously receive a COVID-19 Vaccine?: Yes.  No follow-up attempts are possible. No further information is expected.