Lymph node on right inguinal area, initially non tender, lymph node size of a lima bean 1.5 cm and half a cemtimeter wide; Athralgias; Myalgias; Lymph node on her right inguinal area which was initially non-render then became tender later; It initially got smaller but gets irritated when she sits down; This spontaneous case was reported by a nurse and describes the occurrence of TENDERNESS (Lymph node on her right inguinal area which was initially non-render then became tender later), IRRITABILITY (It initially got smaller but gets irritated when she sits down), LYMPHADENOPATHY (Lymph node on right inguinal area, initially non tender, lymph node size of a lima bean 1.5 cm and half a cemtimeter wide), ARTHRALGIA (Athralgias) and MYALGIA (Myalgias) in a 74-year-old female patient who received mRNA-1273 BIVALENT .222 (MODERNA COVID-19 VACCINE, BIVALENT (ORIGINAL AND OMICRON BA.4/BA.5)) (batch no. 062F22A) for COVID-19 prophylaxis.     The patient's past medical history included Thyroid nodule. Previously administered products included for Product used for unknown indication: Pfizer (Dose 1, lot number EN6203) on 08-Mar-2021, Pfizer (Dose 2, lot number EP7584) on 29-Mar-2021, Pfizer (1st booster dose and lot number EW0187) on 14-Aug-2021; for Flu vaccination: Flu vaccine on 04-Oct-2022. Past adverse reactions to the above products included No adverse event with Flu vaccine, Pfizer, Pfizer and Pfizer. Concurrent medical conditions included Atopic dermatitis (atopic dermatitis around the mouth allergic to toothpaste this was 5 years ago), Toothpaste allergy (atopic dermatitis around the mouth allergic to toothpaste this was 5 years ago), Immune disorder (NOS) (Hyperimmune response), Interleukin level increased (Increased interleukin release), Hypertension, High cholesterol, Diabetes and Obesity. Concomitant products included ASCORBIC ACID (VIT C), ZINC, METFORMIN, ATORVASTATIN, LISINOPRIL, HYDROCHLOROTHIAZIDE and LEVOTHYROXINE SODIUM (SYNTHROID) for an unknown indication.    On 16-Nov-2022 at 11:00 AM, the patient received fifth dose of mRNA-1273 BIVALENT .222 (MODERNA COVID-19 VACCINE, BIVALENT (ORIGINAL AND OMICRON BA.4/BA.5)) (unknown route) 1 dosage form. In November 2022, the patient experienced TENDERNESS (Lymph node on her right inguinal area which was initially non-render then became tender later), IRRITABILITY (It initially got smaller but gets irritated when she sits down), ARTHRALGIA (Athralgias) and MYALGIA (Myalgias). On 16-Nov-2022, the patient experienced LYMPHADENOPATHY (Lymph node on right inguinal area, initially non tender, lymph node size of a lima bean 1.5 cm and half a cemtimeter wide). At the time of the report, TENDERNESS (Lymph node on her right inguinal area which was initially non-render then became tender later), IRRITABILITY (It initially got smaller but gets irritated when she sits down), LYMPHADENOPATHY (Lymph node on right inguinal area, initially non tender, lymph node size of a lima bean 1.5 cm and half a cemtimeter wide), ARTHRALGIA (Athralgias) and MYALGIA (Myalgias) had not resolved.        For mRNA-1273 BIVALENT .222 (MODERNA COVID-19 VACCINE, BIVALENT (ORIGINAL AND OMICRON BA.4/BA.5)) (Unknown), the reporter did not provide any causality assessments.   The patient did not experienced a similar event in the past. The patient never had COVID positive test or diagnosis. The patient received 2nd booster dose on 15-Apr-2022 with lot number 048L21A. It was reported that in the evening of the same day of vaccination, after 8-10 hours, while patient was taking a shower, she noted the lymph node on her right inguinal area which was initially non-render then became tender later. It was the size of a lima bean 1.5 cm and half a centimeter wide. It initially got smaller but it gets irritated when she sits down so she thinks it had not decreased in size. The AE did not cause patient to seek medical care. No treatment medication was provided.   This case was linked to US-MODERNATX, INC.-MOD-2022-675719, US-MODERNATX, INC.-MOD-2022-675742 (Linked Report).; Sender's Comments:  US-MODERNATX, INC.-MOD-2022-675719:Friend case US-MODERNATX, INC.-MOD-2022-675742:Other people case