fatigue; Throat tightness; sore throat; Rash; This is a spontaneous report from a contactable consumer. A 25-years-old female patient received bnt162b2 (PFIZER-BIONTECH COVID-19 VACCINE), via an unspecified route of administration, administered in arm right on 06Mar2021 14:30 (Lot Number: EN6025) as single dose for covid-19 immunisation. Medical history included known allergies: Penicillin. No other vaccine received in four weeks. Concomitant medication included diphenhydramine hydrochloride (BENADRYL), took the week prior to receiving the vaccine. The patient previously took amoxicillin and experienced rash (Amoxicillin tablets. Had allergic reaction when taken 5-7 years ago and did experience similar skin rash, this is the only other reaction in lifetime).   The patient experienced sore throat, throat tightness and rash, all on 06Mar2021 14:30. Clinical course: After receiving COVID 19 Vaccine, within one to two minutes of vaccine very strong sore throat and tightening of the throat. Was taken to emergency room by the ambulance that was at the testing center. At that time the ambulance at testing center recommended taking two Benadryl's, which started to work and sore throat and tightness completely went away about 15 minutes after that and then started to come back at time of riding in ambulance to the ER. While being written up and vitals checked, the rash (blotchy) developed to which she was given a Solumedrol steroid shot to fix the rash which amazingly cleared up rash and it ended up back to white. Had amazing clear photos of rash and it being red and sloshes starting to appear. After caller left ER and went home and had couple of follow up prescriptions of Pepcid and Atarax to help combat rash for two days. Now she was taking Allegra still for adverse events. Reporter mentioned sore throat was on and off but it had improved and still had a little bit of a rash. Caller had a little bit of tightness and it had improved if she exerted herself a lot the tightness got worse she wsn't referring to a big exertion but provided example like if she is going to the grocery store. The rash was severely reduced but was apparent. Caller also mentioned she had pretty severe fatigue after receiving vaccine unsure if this was because of the vaccine or an allergic reaction to some medication in her. She missed work on Monday and part time on Tuesday due to having to take breaks and naps during the day. Caller went into work but she did not feel up to working a full day in the office and was working remotely from home right now. The patient had allergic reaction to amoxicillin tablets when taken 5-7 years ago and did experience similar skin rash, this is the only other reaction in lifetime. Caller stated she knew how important it is to report not sure if there is an association between Amoxicillin and COVID ingredients. May have another allergy that was contributing but Amoxicillin was only other known allergy. Caller was asking for the next steps since she still has not fully recovered her throat, she is still feeling sore and tighter than normal and her skin was still redder than normal. When she had the rash it was red blotchy and warm to the touch it was no longer warm to the touch. Outcome of the events sore throat, throat tightness and rash was recovering, of event fatigue was unknown.