Information has been received from a physician concerning a 4 month old female with no known drug allergies who on 8JAN2003 and 5MAR2003 was vaccinated with a dose of hepatitis B virus vaccine + Hib conj vaccine. On 8JAM2003 and 5MAR2003 the patient was also vaccinated with a dose of diphtheria toxoid +pertussis vaccine + tetanus toxoid, a dose of poliovirus vaccine, and a dose of pneumococcal vaccine. There was no other concomitant medication. on 1APR2003 the patient woke up with a "mattery" left eye. She had no preceding symptoms and no current cold symptoms. Her temperature was 36.7 degrees C. On physical examination the conjunctive of her eyes was clear. There was a little trace of matter in the left eye lashes. The mother was given a prescription for erythromycin estolate to use if the infant's eye became red and blood shot, otherwise he just wanted to treat the eye simply by gently removing the mattering. On 15AUG2003 the patient was seen for a well child visit and was vaccinated with a dose of hepatitis B vaccine recombinant and a dose of polio virus vaccine. An examination of the eyes noted that the conjunctives were non  injected; the sclerae anicteric; lids without ptosis, edema, or erythema; extraocular movements were intact and pupils were equal, round and reactive to light. On 1DEC2003 the patient was seen in the physician's office with a mild upper respiratory infection x 1 week, a fever, and was irritable. She was teething, her appetite was "OK" but she was very fussy at times. She had a low grade temperature that morning and had received ibuprofen at 1100. Her temperature in the office was 36.3 degrees C. Her chest had no symptoms of shortness of breath and her lungs were clear with no wheezing or consolidation. her left tympanic membrane was "injected" her pharynx had mild erythema, and no exudate. The patient was diagnosed with otitis media and was treated with amoxicillin 125 mg/5ml, 5ml tid x 10 days. She was to return to the office in three days for immunizations as scheduled, sooner if she became worse or developed new symptoms. On 13FEB2004 the patient was seen for a well child visit and vaccinated with a dose of diphtheria toxoid + Hib conj vaccine + pertussis vaccine +tetanus toxoid. It was noted that the pneumococcal vaccine was unavailable. On physical examination it was noted that on both ears her tympanic membranes were gray, with sharp landmarks and mobile, and her tonsils were small and non-inflamed bilaterally. On 17FEB2004 the patient developed a fever that had gone up to 103 for the last 24 hours. Her temperature in the office was 38.6 degrees C. There was no cough, congestion , runny nose or diarrhea. it was noted that at 0250 the patient had received acetaminophen an at 1000 had received ibuprofen. The physician noted that there was no clear source of the fever and that "for now", it would be treated with antipyretics an observation. If she was looking more sickly, her mother would bring her back. It was also noted that the patient had had no previous reaction to the diphtheria toxoid+ hib conj vaccine that the patient had had no previous reaction to the diphtheria toxoid +hib conj vaccine + pertussis vaccine + tetanus toxoid vaccination. Additional information has been requested. It was also reported that the patient's mother was vaccinated with a dose of varicella virus vaccine live and developed an adverse event.