Polymyalgia rheumatica; loss of arm movement; lost all mobility in right arm; severe pain; increase inflammatory marker; frozen shoulder syndrome; major inflammatory response in her body; Couldn't move arm, Lost mobility in right arm/can't use or lift her right arm.; nausea; sick; fever; flu-like symptom; muscle cramping in her arms and across her neck/entire shoulder on the opposite side was completely cramped up; This case was reported by a consumer via call center representative and described the occurrence of polymyalgia rheumatica in a 81-year-old female patient who received Herpes zoster (Shingrix) for prophylaxis.   Concomitant products included benzoyl peroxide (Oxy), steroids nos (Steroids) and morphine.   On 24th July 2019, the patient received the 1st dose of Shingrix (intramuscular). In July 2019, less than a week after receiving Shingrix, the patient experienced muscle cramp. On 24th July 2019, the patient experienced sickness, fever, influenza-like symptoms and nausea. On an unknown date, the patient experienced polymyalgia rheumatica (serious criteria GSK medically significant), arm paralysis (serious criteria GSK medically significant), immobile (serious criteria GSK medically significant), pain, inflammatory marker increased, frozen shoulder, inflammation and mobility decreased. On an unknown date, the outcome of the polymyalgia rheumatica, arm paralysis, immobile, muscle cramp, sickness, fever, influenza-like symptoms, pain, inflammatory marker increased, nausea, frozen shoulder, inflammation and mobility decreased were recovering/resolving.   It was unknown if the reporter considered the polymyalgia rheumatica, arm paralysis, immobile, muscle cramp, sickness, fever, influenza-like symptoms, pain, inflammatory marker increased, nausea, frozen shoulder and mobility decreased to be related to Shingrix. The reporter considered the inflammation to be related to Shingrix.  Additional details were provided as follows: The case was reported by daughter on behalf of her mother. The patient also experienced muscle cramping in her arms and across her neck and it progressively got worse and by 31st July 2019. On 1st August 2019, the patient went to emergency room and her entire shoulder on the opposite side was completely cramped up and she could not move her arm and she was in severe pain.   The patient also experienced frozen shoulder syndrome and it progressively got worse and traveled down her arm and attacked her joints and settled in her wrist and she lost all mobility in right arm and it went into her left jaw and left knee and hip.   Laboratory tests were drawn and found that her inflammatory markers were elevated at 125 and then they went to 237 or 247. On 4th August 2019, the patient rushed to the emergency room by an ambulance. After performing all the lab tests none of her symptoms were diagnosed. The reporter waited for the results but believed it could be JCE or PMR . The patient had underwent surgery to remove some arteries from the left and right side of her head to rule out any diagnosis.  The patient's rheumatologist had seen reports of inflammation after receiving Shingrix and believed that she had  a major inflammatory response in her body. The results from the surgery and test would obtained on the day after date of reporting.  At the time of reporting, the patient received treatment with heavy duty steroids and was improving.   The patient also received Morphine and Oxy and a combination of medications that did not touch the pain.  The patient's pain level went from 10 plus to around a 2 or 3 (at the time of reporting) at the time of resting.  The patient could not use or lift her right arm. The reporter consented to follow up.      Lab Comments: The inflammatory markers were elevated at 125 and then they went to 237 or 247.