started having periods again and I have been post menopausal for 14 years; substantial mensuration period; I also had a period and it kindly dwindled off but it created a whole bunch of hormonal imbalances for me; I had to go off hormone which caused me to have an extensive migraine headache; pinched severely in my neck; This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP). The reporter is the patient.  A 60 year-old female patient received bnt162b2 (BNT162B2), intramuscular, administered in arm left, administration date 19Apr2021 (Lot number: EW0164) at the age of 60 years as dose 2, single for covid-19 immunisation. Relevant medical history included: "Osteoporosis" (unspecified if ongoing), notes: Verbatim: osteoporosis. Concomitant medication(s) included: ESTROGEN; PROGESTERONE. Vaccination history included: Bnt162b2 (DOSE 1, LOT# and Expiration Date: Consumer stated, "It was ER8732."), administration date: 29Mar2021, when the patient was 60 years old, for COVID-19 immunization. The following information was reported: MENSTRUAL DISORDER (non-serious) with onset 26Apr2021, outcome "not recovered", described as "started having periods again and I have been post menopausal for 14 years"; HEAVY MENSTRUAL BLEEDING (non-serious) with onset 26Apr2021, outcome "not recovered", described as "substantial mensuration period"; HORMONE LEVEL ABNORMAL (non-serious) with onset 26Apr2021, outcome "not recovered", described as "I also had a period and it kindly dwindled off but it created a whole bunch of hormonal imbalances for me"; MIGRAINE (non-serious) with onset 26Apr2021, outcome "not recovered", described as "I had to go off hormone which caused me to have an extensive migraine headache"; NECK PAIN (non-serious) with onset 26Apr2021, outcome "not recovered", described as "pinched severely in my neck". The event "pinched severely in my neck" was evaluated at the physician office visit. Relevant laboratory tests and procedures are available in the appropriate section. Therapeutic measures were taken as a result of menstrual disorder, heavy menstrual bleeding, hormone level abnormal, migraine, neck pain.   Additional information: It was reported that when she had her second Pfizer shot which was last Apr, within a week, she started having periods again and had been post-menopausal for 14 years. So, she had a pretty substantial menstruation period and then the following month she also had a period and it kindly dwindled off but it created a whole bunch of hormonal imbalances for her and she was not sure if she can get a booster shot. The patient had no Prior Vaccination (Within four weeks). Other medical condition and Concomitant Medication: she just takes hormones. She takes estrogen and progesterone. She also has osteoporosis but does not take medication for it. She had two MRIs and probably a blood test. They had to check her hormone level and they had to give her an Autopsy biopsy they had to figure out if she had endometrial cancer. She had two MRIs of her neck and had multiple blood tests. She dies not have periods any longer but it disrupted her hormone pretty severely and had to go off hormone which caused her to have an extensive migraine headache. It was three weeks long and then pinched severely in her neck. She was seeing an acupuncturist and they were ongoing in for steroid treatments in her neck on Thursday. She took the medication for anti-inflammatory for a while. She does not take that any longer.  No follow-up attempts are possible. No further information is expected