throat closing, tongue swelling, face swelling and a hard time breathing/ diagnosed her symptoms as angioedema; potassium was low and sodium was low; potassium was low and sodium was low; This is a spontaneous report from a contactable consumer (patient). An 88-year-old female patient received her second dose of BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE, lot number: EN6198) at the age of 88-years-old, via an unspecified route of administration in left deltoid on 19Feb2021 at single dose for COVID-19 immunization; losartan potassium (lot number: LJ5020047-A, expiration date: Aug2023), via an unspecified route of administration from 2011 to an unspecified date in 2021 at 50 mg, 1x/day for blood pressure high; diclofenac sodium modified-release tablet (lot number: PW6V5QFTAF61, expiration date: May2022), via an unspecified route of administration from an unspecified date to an unspecified date in 2021 at 75 mg, 1x/day for an unspecified indication; ibuprofen (ADVIL LIQUI GELS, 200 mg strength, lot number: CY1426, expiration date: Jun2022) capsule, via an unspecified route of administration from an unspecified date to an unspecified date in 2021 at 2-4 capsules, as needed (daily) for an unspecified indication; and aflibercept (EYLEA) injection, ophthalmic from an unspecified date to 11Mar2021 at 1 DF (injection), every 8 weeks in each eye for macular degeneration. Medical history included macular degeneration (the wet kind), blood pressure high, spinal stenosis, and thyroid disorder (reported as thyroid something) she provided that it was something like hypotramea (as reported). The patient's concomitant medications were not reported. The patient previously received her first dose of BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE, lot number: EL8982) at the age of 88-years-old, via an unspecified route of administration in right deltoid on 29Jan2021 at 0.3 mL, single for COVID-19 immunization. The patient was calling about the Pfizer COVID-19 vaccine and mentioned that she had a reaction but didn't think it was from the vaccine because it was 5 weeks to the date after the second shot. The reaction was very severe, and she had to visit the emergency room. The patient experienced throat closing, tongue swelling, face swelling and a hard time breathing. She saw her primary care provider after that, and she also saw her PMR doctor- physical medicine and rehabilitation. The doctors recommended that she report this reaction to the COVID 19 vaccine five weeks later. Both doctors thought it might be from the vaccine and it was worth reporting. When asked about the symptoms and if they occurred at that same time, the patient stated yes, and they diagnosed her symptoms as angioedema in the emergency room. This happened on 26Mar2021. The patient was never admitted to the hospital. When asked if angioedema improved, worsened or was persisting, patient stated it was nonexistent now. The events happened after the second dose of the vaccine. The patient had to stop her medications because her primary care provider was unsure what may have caused this reaction, but it may be her medications. She has been taking losartan potassium for about ten years but now had to stop because angioedema could possibly be the result of that, even after ten years. She also had to stop diclofenac sodium because they may have caused that kind of reaction. Having to stop ibuprofen broke her heart as she has taken it for years. This too could have that type of reaction. For aflibercept, she mentioned that she gets the injections in both eyes every eight weeks. She had it 31 times in the right eye and 30 times in the left eye. The reaction she was speaking of, the emergency room, came exactly 2 weeks after she had her last injections, which was on 11Mar2021. Angioedema was an emergency situation, if the throat closes and they couldn't open it up, they may cut into the neck and windpipe. The description was enough to scare her. Both doctors suggested the Pfizer vaccine as just possibly a late reaction. The patient had a basic metabolic panel while in the emergency room. She reported that potassium and sodium was low. Chest Xray- the patient did not have a report on it. Nasal scan was fine. COVID nasal test was negative. Swab for many other kinds of viruses was negative. All of these tests were done on 26Mar2021. The action taken in response to the events for losartan potassium, diclofenac sodium, ibuprofen, and aflibercept was unknown. The outcome of the event "potassium was low and sodium was low" was unknown and recovered on an unspecified date in 2021 for the other event.