went from being good to having both kidneys only functioning at 55%/The caller has dropped from 65% functioning; was almost 158 pounds to 159 pounds and now she is down to 134 pounds; This is a spontaneous report from a contactable consumer (patient).   A 62 year-old female patient received bnt162b2 (PFIZER-BIONTECH COVID-19 VACCINE, Solution for injection, Lot number: EN6199, Expiry date: Unknown), via an unspecified route of administration, administered in left arm on 19Apr2021 (at the age of 61 years) as dose 2, single for COVID-19 immunization. Medical history included thyroid, anxiety, and broken her foot last year, all from an unknown date and unknown if ongoing. Family history included: whole family took the Johnson and Johnson vaccine for COVID-19 immunisation. Concomitant medication included levothyroxine sodium (SYNTHROID) for thyroid, and unspecified anxiety medication, both start and stop date were not reported. Patient previously received first dose of bnt162b2 (Lot number: EN6205, Expiry date not reported) via an unspecified route of administration on in left arm 29Mar2021 (at the age of 61 years) as dose 1, single, for COVID-19 immunization; and flu shots on an unspecified date, but she doesn't remember having reactions, they have been fine. No prior vaccination within 4 weeks prior to vaccination. On an unknown date in Jun2021, the patient went from being good to having both kidneys only functioning at 55%/ the caller has dropped from 65% functioning of both kidneys down to 55% functioning of kidneys. The patient was almost 158 pounds to 159 pounds and now she is down to 134 pounds, on an unspecified date. As reported clinical course: She had Pfizer shots in Mar2021 and Apr2021 and when she got her blood work done in Jun2021, 6 months after the blood work in Jan2021, it came back bad for her kidneys. She had the blood work done a 2nd time recently and it came back bad again and now she is seeing a kidney specialist for this. She went from being good to having both kidneys only functioning at 55% and the vaccine is the only thing that is different, it was the only thing that she had done different this year than what she normally does which was her blood work for her Synthroid. Last year, at the end of the year, she was almost 158 pounds to 159 pounds and now she was down to 134 pounds. That was what started this whole thing, her weight loss. She didn't think about it being related to the vaccine until last night because she has been dissecting this for the last week and half and thinking of what she has done differently in the last year. She has been at 65% for her kidney function up until after she had the vaccine and, now she is at 55%. She was at 65% her whole life, which is high and it's good, but after she had the vaccine and went and got her 6 months review of her bloodwork, because she goes every 6 months, it had went to 55%. So, it dropped from 65% to 55% in both kidneys in Jun2021 and then it had happened again. Caller confirmed that the drop was noticed in Jun2021 and then she had her blood tested again and it came back again at 55%. When it had came back at that level again her doctor had sent her to the kidney specialist who said that it was at 55% the last two times and all the previous stuff that was sent to him was good until Jan2021. Caller clarified and confirmed that her blood work was good in Jan2021 and then in Jun2021 is when it fell from 65% to 55% and the only thing that was done different in her whole life was the Pfizer COVID vaccines that she had in Mar2021 and Apr2021. Patient can't remember when redraw was for the bloodwork that showed the results of 55% kidney functioning again. She stated, it may have been around her birthday, but actually it was probably in Aug2021 or maybe Sep2021, she doesn't know when but probably Sep2021. Patient reported, she didn't know it was that low until she went to the specialist. Her doctor, which is her GP (documented as provided by caller) didn't know the percentage but he knew that it had gone down a lot and so he had sent the caller to the specialist and said that he didn't like the way it was looking. At that time the caller thought that only 1 kidney was affected, she didn't know how bad it was and that it was with both. She had no pain or no blood in her urine, she had none of that. But she was losing weight like crazy. She has lost another 5 pounds in the last 4 days. She is losing pounds like crazy which is probably good for most people but not for her at her age and with something else going wrong, it was not good. Inquired for when the weight change was noticed, and she said that she had broken her foot last year. When she was going to the gym, she was only doing little stuff and once she got better, she was able to do some jogging at the gym and did more cardio. She was going regularly, and she wasn't dropping lots of weight she would just drop a pound here and there. Since she works 2 jobs with a night job she is going less, she is only going 2 days a week and she was going 5 days a week before. But now she is dropping weight faster than she was before. She was wearing a 36 waist and now she has put enough holes in them to be a 32 and had added 2 more holes below the 32. Her lowest waist was a 29 when she was in high school, and she is heading back that direction. She has dropped a lot, but she really noticed it because she has to put a belt on for her pants and everything is baggy. Her face had sunken in, and she feels okay, she feels alright, and she has no pain or anything, but she thought something like this was happened because she has gotten older or maybe she is shrinking, she doesn't know. Patient reported that, vaccination was very early in the morning and had to be no later than 9:00 AM for both doses. Caller had to follow up with her doctor and a kidney specialist, but she has not had to have a hospital stay as of yet. She hasn't seen the test results since they just took the sonogram, and she did additional bloodwork today. She won't see the specialist until 06Dec2021 when that comes back. The patient underwent lab tests and procedures which included blood test: 55% kidney functioning on an unspecified date, blood test: 65% kidney functioning in Jan2021, blood test: 55% kidney functioning in Jun2021, weight: she is down to 134 pounds on an unspecified date in 2021, and sonogram: unknown result on an unspecified date. Event being good to having both kidneys only functioning at 55%/The caller has dropped from 65% functioning of both kidneys down to 55% functioning of kidneys was considered medically significant. The outcome for both events was unknown.