he felt like a train hit him; black bumps; rash with tiny itchy bumps all over his body; rash with tiny itchy bumps all over his body; he had a fever, diarrhea and muscle aches; he had a fever, diarrhea and muscle aches; he had a fever, diarrhea and muscle aches; This non-serious case was reported by a consumer via call center representative and described the occurrence of feeling abnormal in a 60-year-old male patient who received Herpes zoster (Shingrix) for prophylaxis.   Previously administered products included Shingrix with an associated reaction of feeling abnormal (received first dose in November 2022 and felt like a bus hit him, refer case US2023094033).   On 05-MAY-2023, the patient received the 2nd dose of Shingrix (intramuscular, right arm) .5 ml. On 05-MAY-2023, 8 hrs after receiving Shingrix, the patient experienced fever (Verbatim: he had a fever, diarrhea and muscle aches), diarrhea (Verbatim: he had a fever, diarrhea and muscle aches) and muscle pain (Verbatim: he had a fever, diarrhea and muscle aches). On 09-MAY-2023, the patient experienced itchy rash (Verbatim: rash with tiny itchy bumps all over his body) and generalized rash (Verbatim: rash with tiny itchy bumps all over his body). On 10-JUL-2023, the patient experienced skin discoloration (Verbatim: black bumps). On an unknown date, the patient experienced feeling abnormal (Verbatim: he felt like a train hit him). The patient was treated with aciclovir (Acyclovir) and STEROID SHOT (NOS). Rechallenge with Shingrix was positive. The outcome of the feeling abnormal was not reported and the outcome of the fever, diarrhea, muscle pain, itchy rash and generalized rash were resolved and the outcome of the skin discoloration was not resolved.   It was unknown if the reporter considered the feeling abnormal, fever, diarrhea, muscle pain, itchy rash, generalized rash and skin discoloration to be related to Shingrix.     It was unknown if the company considered the feeling abnormal, fever, diarrhea, muscle pain, itchy rash, generalized rash and skin discoloration to be related to Shingrix.   Linked case(s) involving the same patient:  US2023094033   Additional Information: GSK Receipt Date: 10-JUL-2023 The reporter was a patient. The reporter commented on the social media about his ordeal with the Shingrix vaccine. The patient got his second Shingrix vaccine and felt like a train hit him this time.  About 8 hours after he received the second Shingrix dose he had a fever, diarrhea and muscle aches that resolved after 3 to 4 days.  On 9th May 2023, the patient developed a rash with tiny itchy bumps all over his body.  The patient said he went to the health care professional who prescribed 10 tabs of Acyclovir, after he took them, he went back to the health care professional , and she prescribed 20 more Acyclovir. After he finished the tabs, he went back to the health care professional, and she gave him a steroid shot and a 6-day steroid dose pack.  The patient stated the rash was gone and the tiny bumps were now black.  The health care professional was doing a drug test to determine kidney damage from the Acyclovir. The patient gave permission to contact his health care professional. The reporter consented to follow-up.; Sender's Comments:  US-GSK-US2023094033:Original Case : US2023094033