diagnosed with Graves; she was in a lot of pain; extreme fatigue and feeling tired; chills; fever; muscle pain; This is a spontaneous report from a contactable consumer (patient).   A 45-years-old female patient received BNT162B2 (PFIZER-BIONTECH COVID-19 mRNA VACCINE), dose 1 via an unspecified route of administration, administered in Arm Right on 03Apr2021 15:30 (Batch/Lot Number: EW0151), age at vaccination of 45-years-old, as single dose, for covid-19 immunisation.  Medical history was none, patient is perfectly healthy.  The patient was not pregnant and was not pregnant at the time of vaccination. There were no concomitant medications. The patient did not receive any other vaccines within 4 weeks prior to the COVID vaccine. The patient experienced extreme fatigue and feeling tired since getting the vaccine on 03Apr2021, right after the shot, she also had chills, fever and muscle pain. Treatment was administered and the patient recovered from these events fatigue, chills, fever and muscle pain on an unspecified date in Apr2021 (It all went away in 2 and a half to 3 days). The night of 04Apr2021, she was in a lot of pain and had taken Advil. The patient went to bed 10Apr2021 and had a lot of/extreme fatigue (was dramatic and way too tired) and her heart rate was up; she has no appetite, was extremely hungry but did not really feel like eating, had no energy, no matter how much she ate on 10Apr2021.  The events resulting in emergency room/department or urgent care and doctor or other healthcare professional office/clinic visit; patient went to the emergency room, she was really scared about her heart rate, she was observed her for a little bit and then sent her back, wanting the endocrinolo-gist to check on her. The doctor did a bunch of blood tests and her thyroid came out very high, she saw an endocrinologist and they tested her antibodies and she was diagnosed with Grave's disease. Patient was treated with methimazole 10 mg twice daily to decrease her antibodies and it does lower her immune response since 30Apr2021. Her doctor told her to wait for the second dose and its been 6 weeks now. The patient also experienced weight loss in Apr2021. The patient underwent lab tests and procedures which included antibody test abnormal thyroid antiboides abnormal on 10Apr2021, heart rate 120 on 10Apr2021, investigation: everything else came back good everything normal in Apr2021. Prior to vaccination, the patient was not diagnosed with COVID-19. Since the vaccination, the patient has not been tested for COVID-19. The patient was recovered from the events fatigue, chills, fever and muscle pain on an unspecified date in Apr2021. The patient was considered to be recovering from the events extreme fatigue (onset 10Apr2021) and weight loss (has kind of stabilized and is not losing anymore). The patient was considered to be recovering from the event high heart rate/heart began, she has been watching her level of activity, If she goes up or down the stairs, her heart rate can go up to 120, so she is taking it easy. It is slowly getting better. The doctor said the medication may take a couple of weeks to show some improvement. It has been almost 2 weeks. Outcome of all other events was unknown.