not feeling good; kidney filtration was less than stable; white blood cells were up a little bit; having a flare of her Lupus nephritis; having a flare of her Lupus nephritis; exhausted tired; nausea; weak; Really bad headache; diarrhea; exhausted/extreme fatigue; massive headache; muscle ache; joint ache; UTI or kidney infection; UTI or kidney infection; she felt lousy; This is a spontaneous report from a Pfizer sponsored program. This 54-year-old female consumer (patient) reported for herself: A 54-year-old female patient received second dose of bnt162b2 (PFIZER-BIONTECH COVID-19 VACCINE, formulation: solution for injection, Batch/Lot Number: EW0153), via an unspecified route of administration, administered in Arm Left on 06Apr2021 at 17:00 (at the age of 54-year-old) as single dose for covid-19 immunization. Medical history included: ongoing lupus nephritis (she was diagnosed with Lupus when she was 32 years old 22-24 years ago), ongoing hiatus hernia year ago (she was having issues with reflux and went for an endoscopy and diagnosed with hiatal hernia was about a year ago). Concomitant medications included mycophenolate mofetil (MYCOPHENOLATE) taken for lupus nephritis from an unspecified start date and ongoing; verapamil taken for lupus nephritis from an unspecified start date and ongoing; losartan taken for lupus nephritis from an unspecified start date and ongoing; pantoprazole taken for hiatus hernia from an unspecified start date and ongoing; sertraline hydrochloride (ZOLOFT) taken for menopause from an unspecified start date and ongoing; hydroxychloroquine taken for lupus nephritis from an unspecified start date and ongoing. The patient previously took lisinopril on an unspecified date and experienced the events Tongue and Throat to swell (ongoing Allergic to Lisinopril 5 mg she was hospitalized for 3 days (years ago). Patient historical vaccine included first dose of bnt162b2 (PFIZER-BIONTECH COVID-19 VACCINE, formulation: solution for injection, Batch/Lot Number: EN6207), via an unspecified route of administration, administered in Arm Left on 18Mar2021 (at the age of 54-year-old) as single dose for covid-19 immunization and experienced the events Sore arm and Tiredness. Patient previously took flu vaccine on an unspecified date and experienced little soreness on an unspecified. Caller reported that she has been plagued with a lot of the symptoms that come with the Covid-19 vaccine including headache, nausea, joint pain, and tiredness. Caller reported that her Lupus has been in remission for a while and that she takes Mycophenolate for Lupus Nephritis. Caller reported that she received the second dose of the Covid-19 vaccine at 17:00 on 06Apr2021.Caller reported that she made sure that she drank a lot of water that day and didn't pre medicate before receiving the Covid-19 vaccine that she felt ok the night of 06Apr2021 and during the day on 07Apr2021 around 20:00 on 07Apr2021, she hit the wall. Caller reported that she was exhausted, had a massive headache, muscle aches, joint aches, and extreme fatigue. Caller reported that she drank some more fluids and went to bed. Caller reported that she woke up the next morning on 08Apr2021, had one bout of bad diarrhoea, and then all the sudden all other symptoms were gone on 08Apr2021 at 11:00. Caller reported that she then felt fine until 26Apr2021. Caller reported that on26Apr2021, her symptoms returned. Caller reported that she felt exhausted tired, nauseous, and weak. Caller reported that she let it go for 3-4 days then called her rheumatologist to inform them that's something is off, and she is not feeling good. Caller reported that she thought that she was having a flare of her Lupus. Caller reported that her rheumatologist ordered a bunch of blood work. Caller reported that the labs came back showing that her kidney filtration was less than stable and her white blood cells were up a little bit. Caller reported that her rheumatologist ordered a urine test. Caller reported that she called her nephrologist who stated that the caller could have a UTI or kidney infection. Caller reported that her nephrologist got her started on Cipro until the urine culture came back. Caller reported that the urine culture came back negative, but it was a good 10 days to 2 weeks that she felt lousy. Caller reported that she finished the Cipro even though she didn't have a UTI. Caller reported that her nausea, headache, feeling of weakness, and exhaustion then went away. Caller stated that she is just wondering if because she is taking Mycophenolate and it suppresses the immune system that it just took longer for the Covid-19 vaccine to work for her. Caller stated that she is wanting to know what her immunity percentage is or how the Covid-19 vaccine will work since she's taking immunosuppressant medications. Caller reported that she has been doing research and noticed that her medication, Mycophenolate, is listed as having the possibility of causing a lower efficiency rate for the Covid-19 vaccine. Caller inquired if there is a test that can be done or ordered to check her immunity levels. Caller reported that she read something about stackable protein being checked. Caller stated that she is just afraid that being on the Mycophenolate affected the efficacy of the Covid-19 vaccine. Patient thought having a Lupus flare she reported that the exhausted tired feeling, nausea, really bad headache, and weak feeling that developed on 26Apr2021 made her think that she was having a flare of her Lupus. Caller reported that the exhausted tired feeling, nausea, really bad headache, and weak feeling that made her think that she was having a flare of her Lupus lasted about 2 weeks. Caller reported that her symptoms resolved at the beginning of last week. Caller reported that her daughter is 27 and the only time the caller has been off Hydroxychloroquine was 3months before and while pregnant with her daughter. Caller reported that she takes the blood pressure medications Verapamil and Losartan not because she has high blood pressure but for her kidneys because of the Lupus Nephritis. Caller reported that she was having problems with menopause and her gynaecologist suggested that sometimes Zoloft can help with hot flashes and things like that. Caller reported that she some-times takes a multi vitamin, vitamin D, and vitamin C. Investigations: Caller reported that her rheumatologist ordered a bunch of blood work. Caller reported that the labs came back showing that her kidney filtration was less than stable and her white blood cells were up a little bit. Caller reported that she was tested for Covid-19 before going to the gynaecologist. Caller reported that she has been tested for Covid-19 multiple times because of the joint aches, headaches, and muscle aches that her Lupus can cause. The patient underwent lab tests and procedures which included culture urine: negative on 03May2021, glomerular filtration rate: less on unspecified date (kidney filtration was less than stable), sars-cov-2 test negative: negative on 10May2021, urine analysis: white blood cell-2 on 03May2021, urine analysis: white blood cell- over 30 on 07May2021. Patient visited to Physician Office for the events Exhausted tired, nauseous, felt weak, thought having a flare up of Lupus. Therapeutic measures were taken as a result of the events UTI or kidney infection with Cipro. The outcome of the events exhausted/extreme fatigue, massive headache, muscle ache, joint ache recovered on 08Apr2021 at 11:00, diarrhoea recovered on 08Apr2021, exhausted tired, nausea, weak, really bad headache and having a flare of her Lupus nephritis recovered on May2021, UTI or kidney infection and she felt lousy recovered on unspecified date in 2021, not feeling good, kidney filtration was less than stable and white blood cells were up a little bit was unknown.   Information about batch/lot number is available further information has been requested.