Achy; On the 3rd day, it was hard to focus. However, by afternoon could focus; On the 2nd day, felt like had a really bad hangover; All doses have been bad, but this was extreme and severe,Worse with some additional things,like immune response is in overdrive.About 32 to 34 hours later symptoms very extreme; hot/so hot today; couldn't roll over because it hurts; By noon on Monday, reports lying horizontal in bed feeling too horrible to sit up; headache; Nauseous,if I sit up, felt like I was going to throw up,Still feels a little nauseous; chills; rash under lymph node area upper left breast; Tired the first couple of days; Foggy the first couple of day; Skin hurt to touch; Like worst flu she ever had,Symptoms kept getting worse and would ramp up; Not sleeping; Wakes up in cold sweat; Has stomach upset; This spontaneous case was reported by a patient and describes the occurrence of IMMUNISATION REACTION (All doses have been bad, but this was extreme and severe,Worse with some additional things,like immune response is in overdrive.About 32 to 34 hours later symptoms very extreme), FEELING HOT (hot/so hot today), MOBILITY DECREASED (couldn't roll over because it hurts), SITTING DISABILITY (By noon on Monday, reports lying horizontal in bed feeling too horrible to sit up) and PAIN OF SKIN (Skin hurt to touch) in a 60-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 012H21B, 012H21B, 004C21A and 037B21A) for COVID-19 prophylaxis. The occurrence of additional non-serious events is detailed below.     The patient's past medical history included Flu (Really bad Flu). Concurrent medical conditions included Blood pressure and Cholesterol. Concomitant products included AMLODIPINE and METOPROLOL for Blood pressure, ROSUVASTATIN for Cholesterol.   On 08-Apr-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 06-May-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 30-Nov-2021, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 13-Jun-2022, received fourth dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 13-Jun-2022, the patient experienced IMMUNISATION REACTION (All doses have been bad, but this was extreme and severe,Worse with some additional things,like immune response is in overdrive.About 32 to 34 hours later symptoms very extreme), FEELING HOT (hot/so hot today), MOBILITY DECREASED (couldn't roll over because it hurts), SITTING DISABILITY (By noon on Monday, reports lying horizontal in bed feeling too horrible to sit up), HEADACHE (headache), NAUSEA (Nauseous,if I sit up, felt like I was going to throw up,Still feels a little nauseous) and CHILLS (chills). On 14-Jun-2022, the patient experienced HANGOVER (On the 2nd day, felt like had a really bad hangover). On 15-Jun-2022, the patient experienced DISTURBANCE IN ATTENTION (On the 3rd day, it was hard to focus. However, by afternoon could focus). In June 2022, the patient experienced PAIN OF SKIN (Skin hurt to touch), INFLUENZA LIKE ILLNESS (Like worst flu she ever had,Symptoms kept getting worse and would ramp up), INSOMNIA (Not sleeping), COLD SWEAT (Wakes up in cold sweat), ABDOMINAL DISCOMFORT (Has stomach upset), FEELING ABNORMAL (Foggy the first couple of day), RASH (rash under lymph node area upper left breast) and FATIGUE (Tired the first couple of days). On 17-Jun-2022, the patient experienced PAIN (Achy). The patient was treated with PARACETAMOL (TYLENOL) at an unspecified dose and frequency and NAPROXEN SODIUM (ALEVE) at an unspecified dose and frequency. In June 2022, FEELING ABNORMAL (Foggy the first couple of day) and FATIGUE (Tired the first couple of days) had resolved. At the time of the report, IMMUNISATION REACTION (All doses have been bad, but this was extreme and severe,Worse with some additional things,like immune response is in overdrive.About 32 to 34 hours later symptoms very extreme), FEELING HOT (hot/so hot today), MOBILITY DECREASED (couldn't roll over because it hurts), SITTING DISABILITY (By noon on Monday, reports lying horizontal in bed feeling too horrible to sit up), PAIN OF SKIN (Skin hurt to touch), INFLUENZA LIKE ILLNESS (Like worst flu she ever had,Symptoms kept getting worse and would ramp up), HANGOVER (On the 2nd day, felt like had a really bad hangover), INSOMNIA (Not sleeping), COLD SWEAT (Wakes up in cold sweat), PAIN (Achy), ABDOMINAL DISCOMFORT (Has stomach upset), HEADACHE (headache), NAUSEA (Nauseous,if I sit up, felt like I was going to throw up,Still feels a little nauseous), CHILLS (chills) and RASH (rash under lymph node area upper left breast) had not resolved and DISTURBANCE IN ATTENTION (On the 3rd day, it was hard to focus. However, by afternoon could focus) was resolving.        For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown), the reporter did not provide any causality assessments.   Patient reported adverse events experienced after receiving the second booster dose. Patient states all doses have been bad, but this was extreme and severe for her. Worse with some additional things. Patient was not immunocompromised.  Patient states that symptoms began 6 hours after receiving the 2nd booster.  About 32 to 34 hours later symptoms were very extreme and states she felt the worst in the world.  On the 2nd day, felt like had a really bad hangover. It was not normal for her. Caller had to call out of work the day after receiving the booster. On the 3rd day, she went back to work, but it was hard to focus. However, by afternoon could focus.  Patient states her symptoms had improved, but some are still ongoing. She is not sleeping, wakes up in cold sweat but still hot. It happened on 17 Jun 2022 as well. Patient states she fell asleep 5am and woke up in cold sweats and achy. She is so hot and still feels a little nauseous/has stomach upset.   This case was linked to MOD-2022-591759, MOD-2022-591774, MOD-2022-591779 (Patient Link).