#1 on 29-Oct-2020 / #2 on 30-Dec-2020 / shot #1 of Covid-19 / get / shingles outbreak; #1 on 29-Oct-2020 / #2 on 30-Dec-2020 / shot #1 of Covid-19 / get / shingles outbreak; Unexpected benefit / Shingrix vaccine series helped with his "herpes simplex."; Shingrix shot "knocked the hell" out of him / he was "down for 3 days"; This case was reported by a consumer via call center representative and described the occurrence of suspected vaccination failure in a 66-year-old male patient who received Herpes zoster (Shingrix) (batch number CZ455, expiry date 16th September 2022) for prophylaxis.   Co-suspect products included Herpes zoster (Shingrix) (batch number CZ455, expiry date 16th September 2022) for prophylaxis and COVID-19 MRNA-1273 VACCINE (COVID-19 VACCINE MODERNA) for prophylaxis.   The patient's past medical history included genital herpes. Previously administered products included Valtrex with an associated reaction of dizziness (had been taking Valtrex 500 mg every day for years and was prescribed 20 years ago, refer case ). Concurrent medical conditions included herpes simplex (Painful upper right side kidney area outbreaks of herpes simplex) and pain (Pain goes from his side to his hip).   On 30th December 2020, the patient received the 2nd dose of Shingrix (intramuscular). On 29th October 2020, the patient received the 1st dose of Shingrix (intramuscular). On an unknown date, the patient received COVID-19 VACCINE MODERNA. On an unknown date, less than 5 months after receiving Shingrix, less than 9 months after receiving Shingrix and an unknown time after starting Valtrex, the patient experienced vaccination failure (serious criteria GSK medically significant), shingles, feels awful and unexpected therapeutic effect. The patient was treated with valaciclovir hydrochloride (Valtrex). On an unknown date, the outcome of the vaccination failure and unexpected therapeutic effect were unknown and the outcome of the shingles and feels awful were recovered/resolved.   It was unknown if the reporter considered the vaccination failure and shingles to be related to Shingrix and Shingrix. The reporter considered the feels awful and unexpected therapeutic effect to be related to Shingrix.  Additional details were reported as follows: This case was reported by patient himself. The age at vaccination was not reported but could be 65 or 66 years. Recently the patient had been taking Valtrex daily to prevent what he calls herpes simplex outbreaks that he gets on his upper right side (kidney area) and the physician said that it was classic shingles.  The patient received 1st dose, refer case and 2nd dose of Shingrix in unspecified deltoid. The patient stated that the Shingrix shot knocked the hell out of him and he was down for 3 days. The patient was told by his physician that he no longer had to take Valtex every day because the Shingrix would help prevent his upper right side outbreaks, so the patient stopped taking Valtrex and wanted to report the unexpected benefit of having Shingrix prevent him from getting another episode of the upper right side outbreaks which he refers to as herpes simplex. The patient wanted  to know that the Shingrix vaccine series helped with his herpes simplex. The patient received 1st dose of Covid-19 (Moderna) vaccine and shortly after that he did get an upper right side shingles outbreak. The patient stated he took a massive amount of Valtrex and it (shingles) went away after 3 to 4 days of Valtrex. The patient had an appointment to get 2nd dose of COVID-19 (Moderna) on the date of reporting therefore he probably got his 1st dose about 28 days ago. It was unknown if the reporter considered the shingles to be related to Covid-19 (Moderna). The reported did not want to share his physician information. The reporter did not consent to follow up. This case was considered as suspected vaccination failure as detail regarding laboratory test confirming herpes zoster was unknown at the time of reporting. This is 1 of 3 cases reported by the same reporter.; Sender's Comments:  :Same reporter. Valtrex case. :Same reporter. Shingrix 1st dose case.