Two meniscus tears in right knee; Right knee swelling; Stiffness in joints; Wearing off effect; Right knee pain; Sickness; This spontaneous case was reported by a consumer and describes the occurrence of ILLNESS (Sickness), MENISCUS INJURY (Two meniscus tears in right knee), JOINT SWELLING (Right knee swelling), JOINT STIFFNESS (Stiffness in joints) and THERAPEUTIC RESPONSE SHORTENED (Wearing off effect) in a 77-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.    Co-suspect product included non-company product ADALIMUMAB (HUMIRA) for Rheumatoid arthritis.    Concurrent medical conditions included Rheumatoid arthritis.   On 28-Jan-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 25-Feb-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. On 30-Nov-2021, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. On an unknown date, the patient started ADALIMUMAB (HUMIRA) (Subcutaneous) at an unspecified dose. In 2021, the patient experienced ILLNESS (Sickness). On an unknown date, the patient experienced MENISCUS INJURY (Two meniscus tears in right knee), JOINT SWELLING (Right knee swelling), JOINT STIFFNESS (Stiffness in joints), THERAPEUTIC RESPONSE SHORTENED (Wearing off effect) and ARTHRALGIA (Right knee pain). At the time of the report, ILLNESS (Sickness) had not resolved and MENISCUS INJURY (Two meniscus tears in right knee), JOINT SWELLING (Right knee swelling), JOINT STIFFNESS (Stiffness in joints), THERAPEUTIC RESPONSE SHORTENED (Wearing off effect) and ARTHRALGIA (Right knee pain) outcome was unknown.            Concomitant medication was not reported.  The patient had two meniscus tears in right knee. Patient had knee surgery in Oct-2021. In 2021, patient's Moderna second shot and booster shot made her sick for three or four days. Patient had right knee pain, swelling, meniscus tears, day before next injection could tell it was time for it because patient get stiffness in joints. Treatment details were not reported.  It was unknown if patient was enrolled in a COVID-19 vaccine Trial.  This case was identified as part of a retrospective clean-up activity where certain emails received in the Moderna mailbox were missed to be booked-in.  Company comment: This spontaneous case concerns a 77 year old female patient with no relevant medical history with reported unexpected non serious event of Therapeutic response shortened,  unknown days after receiving the first dose of mRNA-1273 vaccine in the COVID-19 vaccination series. No information on detailed clinical course including whether the patient had COVID 19 like symptoms, relevant investigations and treatment was available in the report.  Adalimumab used for concurrent rheumatoid arthritis was reported as a co suspect. The benefit-risk relationship of mRNA-1273 is not affected by this report.    This case was linked to MOD-2021-620168 (Patient Link).   Most recent FOLLOW-UP information incorporated above includes: On 11-Apr-2022: Significant follow up received. Events added.; Sender's Comments: This spontaneous case concerns a 77 year old female patient with no relevant medical history with reported unexpected non serious event of Therapeutic response shortened, unknown days after receiving the first dose of mRNA-1273 vaccine in the COVID-19 vaccination series. No information on detailed clinical course including whether the patient had COVID 19 like symptoms, relevant investigations and treatment was available in the report.  Adalimumab used for concurrent rheumatoid arthritis was reported as a co suspect. The benefit-risk relationship of mRNA-1273 is not affected by this report.