Severe peripheral neuropathy; No severe burning in hands; No severe pain in hands; Feeling miserable; Can't open jars, type, carry anything safely; Can't sleep at night; Chest pain (urgent care); Dry cough (urgent care); Severe diaphragm pain on deep inspirational (urgent care); Sob; Hurt to deep breathe (urgent care); This serious case was reported by a consumer and described the occurrence of peripheral neuropathy in a 69-year-old female patient who received Herpes zoster (Shingles vaccine) for prophylaxis.   On 26-OCT-2022, the patient received Shingles vaccine. On 27-OCT-2022, 1 days after receiving Shingles vaccine, the patient experienced chest pain (Verbatim: Chest pain (urgent care)) (serious criteria clinically significant/intervention required). On an unknown date, the patient experienced peripheral neuropathy (Verbatim: Severe peripheral neuropathy) (serious criteria GSK medically significant), dry cough (Verbatim: Dry cough (urgent care)), diaphragmalgia (Verbatim: Severe diaphragm pain on deep inspirational (urgent care)), shortness of breath (Verbatim: Sob), painful respiration (Verbatim: Hurt to deep breathe (urgent care)), burning sensation (Verbatim: No severe burning in hands), pain in hand (Verbatim: No severe pain in hands), feeling miserable (Verbatim: Feeling miserable), activities of daily living impaired (Verbatim: Can't open jars, type, carry anything safely) and insomnia (Verbatim: Can't sleep at night). The patient was treated with ambiguous medication nos (Neurontin (Nos)). The outcome of the peripheral neuropathy and chest pain were not recovered/not resolved and the outcome of the dry cough, diaphragmalgia, shortness of breath and painful respiration were recovered/resolved (duration 10 days) and the outcome of the burning sensation, pain in hand, feeling miserable, activities of daily living impaired and insomnia were not reported.   It was unknown if the reporter considered the peripheral neuropathy, chest pain, dry cough, diaphragmalgia, shortness of breath, painful respiration, burning sensation, pain in hand, feeling miserable, activities of daily living impaired and insomnia to be related to Shingles vaccine.     It was unknown if the company considered the peripheral neuropathy, chest pain, dry cough, diaphragmalgia, shortness of breath, painful respiration, burning sensation, pain in hand, feeling miserable, activities of daily living impaired and insomnia to be related to Shingles vaccine.   Additional Information: GSK receipt date:21-MAR-2023 This report was submitted via the online direct entry reporting system.  The patient reported himself. The patient initially had dry cough, chest pain, shortness of breath, severe diaphragm pain on deep inspirational, hurt to deep breathe it Lasted 10 days. The patient went to urgent care on 1st November 2022 The patient had no severe burning and pain in her hands nonstop. Neurontin did not help. Chiropractor helped a little. She was feeling miserable. She said that she would never take Shingles vaccine again. The patient couldnot open jars, type , carry anything safely, she could not sleep at night and any more things. The patient did not had any problems prior to the vaccine. Severe peripheral neuropathy dise symptoms were treated. The reporter consented to follow up.