After the 2nd one, I started having some... I have arthritis, seems like it made it worse; My left wrist swollen; Swelling in my hands; Pain in my hands; My arthritis pain was getting real bad, mostly at night; This spontaneous case was reported by a consumer and describes the occurrence of PERIPHERAL SWELLING (Swelling in my hands), PAIN IN EXTREMITY (Pain in my hands), CONDITION AGGRAVATED (After the 2nd one, I started having some... I have arthritis, seems like it made it worse), JOINT SWELLING (My left wrist swollen) and PAIN (My arthritis pain was getting real bad, mostly at night) in a 56-year-old male patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 017B21A and 031A21A) for COVID-19 vaccination.     Concurrent medical conditions included Arthritis.   On 18-May-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 18-Jun-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 21-Jun-2021, the patient experienced PAIN (My arthritis pain was getting real bad, mostly at night). On 29-Jun-2021, the patient experienced PAIN IN EXTREMITY (Pain in my hands). On 21-Nov-2021, the patient experienced PERIPHERAL SWELLING (Swelling in my hands). On 24-Nov-2021, the patient experienced CONDITION AGGRAVATED (After the 2nd one, I started having some... I have arthritis, seems like it made it worse) and JOINT SWELLING (My left wrist swollen). The patient was treated with PARACETAMOL (TYLENOL [PARACETAMOL]) at an unspecified dose and frequency and NAPROXEN SODIUM (ALEVE) at an unspecified dose and frequency. At the time of the report, PERIPHERAL SWELLING (Swelling in my hands), PAIN IN EXTREMITY (Pain in my hands), CONDITION AGGRAVATED (After the 2nd one, I started having some.. I have arthritis, seems like it made it worse), JOINT SWELLING (My left wrist swollen) and PAIN (My arthritis pain was getting real bad, mostly at night) outcome was unknown.            As per source document the patient did not have any side effects after first dose. The patient had Arthritis and after second dose only it got worsened and he wore a brace on left hand since it was swollen.  The patient was taking Tylenol and Aleve. Relevant concomitant medications were not provided by the reporter.  Company comment This case concerns a 56-year-old male patient with no relevant medical history, who experienced the unexpected events of Pain, Pain in Extremity, Peripheral Swelling, Condition Aggravated, and Joint Swelling. The event occurred 3 days after receiving the second dose of mRNA-1273 Vaccine. The rechallenge was not applicable since only information about the second dose was disclosed. The benefit-risk relationship of mRNA-1273 Vaccine is not affected by this report.; Sender's Comments: This case concerns a 56-year-old male patient with no relevant medical history, who experienced the unexpected events of Pain, Pain in Extremity, Peripheral Swelling, Condition Aggravated, and Joint Swelling. The event occurred 3 days after receiving the second dose of mRNA-1273 Vaccine. The rechallenge was not applicable since only information about the second dose was disclosed. The benefit-risk relationship of mRNA-1273 Vaccine is not affected by this report.