aggressive B cell non Hodgkins Lymphoma; swollen lymph node was discovered/axillary lymph node swelling/lymph node had grown in size; fatigue; loss of appetite; This spontaneous case was reported by a physician and describes the occurrence of B-CELL LYMPHOMA (aggressive B cell non Hodgkins Lymphoma) in a 74-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch no. 001A21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     The patient's past medical history included Radiation therapy and Lumpectomy (breast cancer). Concurrent medical conditions included Breast cancer female.   On 27-Jan-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 22-Feb-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. In April 2021, the patient experienced LYMPHADENOPATHY (swollen lymph node was discovered/axillary lymph node swelling/lymph node had grown in size). In 2021, the patient experienced DECREASED APPETITE (loss of appetite) and FATIGUE (fatigue). On 23-Nov-2021, the patient experienced B-CELL LYMPHOMA (aggressive B cell non Hodgkins Lymphoma) (seriousness criterion medically significant). At the time of the report, B-CELL LYMPHOMA (aggressive B cell non Hodgkins Lymphoma), DECREASED APPETITE (loss of appetite), LYMPHADENOPATHY (swollen lymph node was discovered/axillary lymph node swelling/lymph node had grown in size) and FATIGUE (fatigue) outcome was unknown.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): In April 2021, Mammogram: swollen lymph node was discovered (abnormal) swollen lymph node was discovered. On an unknown date, Weight: decreased (Low) Patient weighed 120 lbs prior to receiving the vaccine and now weighs 110 lbs..     For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown), the reporter did not provide any causality assessments.   No concomitant medications were reported.  It was reported as in APR2021, the patient went for a routine mammogram where a swollen lymph node was discovered. The doctors didn't think much of it at that time. However, in NOV2021, the patient went to the Hem/Onc doctor and complained of axillary lymph node swelling. Upon further checkup, it was determined that the lymph node had grown in size warranting further diagnostics.  Patient weighed 120 lbs prior to receiving the vaccine. Patient received the 1st chemotherapy cycle on 16DEC2021, the 2nd one on 11JAN2022, and the 3rd one was due for 03FEB2022. Patient would have to go through 6 chemotherapy cycles. Patient had been advised by the primary physician and oncologist to avoid receiving the booster shot of any COVID-19 vaccine for now. Caller and the daughter wanted to know if there had been similar reports of patients being diagnosed with lymphoma after receiving the Moderna vaccine. Consent given for Safety follow-up with caller. Preferred method of contact was phone.  Company Comment - This case concerns a 74 year old female patient with medical history of breast cancer, who experienced the serious unexpected event of B-Cell Lymphoma. The event occurred approximately 9 months after the second dose of mRNA-1273 vaccine. Patient's medical history of breast cancer remains a confounder. The rechallenge was not applicable. The benefit-risk relationship of the mRNA-1273 vaccine is not affected by this report.; Sender's Comments: This case concerns a 74 year old female patient with medical history of breast cancer, who experienced the serious unexpected event of B-Cell Lymphoma. The event occurred approximately 9 months after the second dose of mRNA-1273 vaccine. Patient's medical history of breast cancer remains a confounder. The rechallenge was not applicable. The benefit-risk relationship of the mRNA-1273 vaccine is not affected by this report.