Lips tingling; tongue tingling; tongue felt sick, like swollen; sore arm; muscle cramps; Prickling/Tingling; migraine headaches; multiple swollen and large lymph nodes in the neck/swollen lymph nodes that look like cancer; Itching; Swelling of upper airwayy (lips,tongue, throat, uvula, or larynx); Swelling of upper airwayy (lips,tongue, throat, uvula, or larynx); Swelling of f upper airway (lips,tongue, throat, uvula, or larynx); This spontaneous case was reported by a nurse and describes the occurrence of PARAESTHESIA ORAL (Lips tingling), PARAESTHESIA ORAL (tongue tingling), SWOLLEN TONGUE (tongue felt sick, like swollen), PAIN IN EXTREMITY (sore arm) and MUSCLE SPASMS (muscle cramps) in a 53-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch no. 005C21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     The patient's past medical history included Eczema. Concurrent medical conditions included Brain tumor since 2020, Thyroid cancer since August 2020, Allergy to vaccine (Tachycardia, rapid speech, red rash to face and trunk, utricaria), Allergy to nuts (Macadamia nuts : Wheezing, tightness in throat, utricaria), Allergy to animal dander (Pet dander: Utricaria, wheezing), Food allergy (Yam: Rash over entire body), Ragweed allergy (Sneezing, watery eyes, headache), Thyroidectomy partial (For papillary cancer: Extremely swollen lymph nodes to neck. Being sent for repeat neck mapping/Recent partial thyroidectomy.) since August 2021, Hay fever and Meningioma (Migraines).    On 14-Oct-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 14-Oct-2021, the patient experienced PARAESTHESIA ORAL (Lips tingling), PARAESTHESIA ORAL (tongue tingling), SWOLLEN TONGUE (tongue felt sick, like swollen), PAIN IN EXTREMITY (sore arm), MUSCLE SPASMS (muscle cramps) and PARAESTHESIA (Prickling/Tingling). In October 2021, the patient experienced PRURITUS (Itching), ENLARGED UVULA (Swelling of upper airwayy (lips,tongue, throat, uvula, or larynx)), LIP SWELLING (Swelling of upper airwayy (lips,tongue, throat, uvula, or larynx)), PHARYNGEAL SWELLING (Swelling of f upper airway (lips,tongue, throat, uvula, or larynx)), MIGRAINE (migraine headaches) and LYMPHADENOPATHY (multiple swollen and large lymph nodes in the neck/swollen lymph nodes that look like cancer). The patient was treated with IBUPROFEN (ADVIL [IBUPROFEN]) for Adverse event, at an unspecified dose and frequency and CETIRIZINE HYDROCHLORIDE (ZYRTEC ALLERGY) (oral) ongoing since an unknown date for Anaphylaxis, at a dose of 40 mg. At the time of the report, PARAESTHESIA ORAL (Lips tingling), PARAESTHESIA ORAL (tongue tingling), SWOLLEN TONGUE (tongue felt sick, like swollen), PAIN IN EXTREMITY (sore arm), MUSCLE SPASMS (muscle cramps), MIGRAINE (migraine headaches) and LYMPHADENOPATHY (multiple swollen and large lymph nodes in the neck/swollen lymph nodes that look like cancer) outcome was unknown and PRURITUS (Itching), ENLARGED UVULA (Swelling of upper airwayy (lips,tongue, throat, uvula, or larynx)), LIP SWELLING (Swelling of upper airwayy (lips,tongue, throat, uvula, or larynx)), PHARYNGEAL SWELLING (Swelling of f upper airway (lips,tongue, throat, uvula, or larynx)) and PARAESTHESIA (Prickling/Tingling) had not resolved.        The action taken with mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) was unknown.   For mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular), the reporter considered PRURITUS (Itching), ENLARGED UVULA (Swelling of upper airwayy (lips,tongue, throat, uvula, or larynx)), LIP SWELLING (Swelling of upper airwayy (lips,tongue, throat, uvula, or larynx)), PHARYNGEAL SWELLING (Swelling of f upper airway (lips,tongue, throat, uvula, or larynx)) and PARAESTHESIA (Prickling/Tingling) to be related. No further causality assessments were provided for PARAESTHESIA ORAL (Lips tingling), PARAESTHESIA ORAL (tongue tingling), SWOLLEN TONGUE (tongue felt sick, like swollen), PAIN IN EXTREMITY (sore arm), MUSCLE SPASMS (muscle cramps), MIGRAINE (migraine headaches) and LYMPHADENOPATHY (multiple swollen and large lymph nodes in the neck/swollen lymph nodes that look like cancer).    No concomitant medications were reported.  Patient took an EpiPen and Bronchodilator to vaccination site. After a week patient did a neck mapping to look into lymph nodes. There were multiple swollen and large lymph nodes in the neck.  1 week after vaccine Patient was sent for neck mapping ultrasound to follow up after thyroid surgery in August. Multiple large lymph nodes noted. Radiologist called to patient's  endocrinologist directly to discuss.  Recommended to repeat neck mapping and to send patient for pet scan to rule out metastatic cancer. Patient have history of meningioma that was treated with gamma knife.   Most recent FOLLOW-UP information incorporated above includes: On 10-Nov-2021: Significant follow-up- updated added patient's medical history, allergies and Events.