having flares one after another to the point where patient can't take the pain anymore / minor pain; This spontaneous case was reported by a patient and describes the occurrence of RHEUMATOID ARTHRITIS (having flares one after another to the point where patient can't take the pain anymore / minor pain) in a  patient of an unknown age and gender who received mRNA-1273 (Spikevax) for COVID-19 prophylaxis.     Concurrent medical conditions included Rheumatoid arthritis (in remission for 21 years.). Concomitant products included HYDROXYCHLOROQUINE for Rheumatoid arthritis.    On an unknown date, the patient received dose of mRNA-1273 (Spikevax) (unknown route) 1 dosage form. On an unknown date, the patient experienced RHEUMATOID ARTHRITIS (having flares one after another to the point where patient can't take the pain anymore / minor pain) (seriousness criterion medically significant). The patient was treated with METHOTREXATE for Rheumatoid arthritis, at an unspecified dose and frequency; SULFASALAZINE for Rheumatoid arthritis, at an unspecified dose and frequency and PREDNISONE for Rheumatoid arthritis, at an unspecified dose and frequency. At the time of the report, RHEUMATOID ARTHRITIS (having flares one after another to the point where patient can't take the pain anymore / minor pain) had not resolved. Not Provided      The action taken with mRNA-1273 (Spikevax) (Unknown) was unknown.       It was reported that patient had rheumatoid arthritis for quite some time and was in remission for 21 years. Patient was fine till got the shots .The pain was horrible.   Patient asked rheumatologist if it was because of the shot and both she and cardiologist said they can't rule it out. If there was something know of that can ease all the pain please let know.Patient have been having these flares now for about a year with may be one day a week with just minor pain.  Patient had treatment with hydroxychloroquine along with other medications, nothing was helping out. Company comment: This spontaneous case concerns a patient of unknown age and gender with medical history of Rheumatoid arthritis, who experienced the unexpected, serious (Medically significant) AESI of Rheumatoid arthritis. The exact date of administration of an unknown dose of mRNA-1273 and onset of the event was not specified, hence latency could not be assessed. It has been reported that the patient had Rheumatoid arthritis but was in remission for 21 years, however, after administration of an unknown dose of mRNA-1273, the patient experienced flare-ups. Patient sought consult with a rheumatologist and was prescribed with Hydroxychloroquine, Methotrexate, Sulfasalazine and Prednisone of unknown dose and frequency, but no relief was provided. Details of concomitant medications, medical history, clinical course and treatment were not provided. The event has not resolved at the time of the report. The benefit-risk relationship of mRNA-1273 is not affected by this report. Events' seriousness retained as per Important Medical Event List.; Sender's Comments: This spontaneous case concerns a patient of unknown age and gender with medical history of Rheumatoid arthritis, who experienced the unexpected, serious (Medically significant) AESI of Rheumatoid arthritis. The exact date of administration of an unknown dose of mRNA-1273 and onset of the event was not specified, hence latency could not be assessed. It has been reported that the patient had Rheumatoid arthritis but was in remission for 21 years, however, after administration of an unknown dose of mRNA-1273, the patient experienced flare-ups. Patient sought consult with a rheumatologist and was prescribed with Hydroxychloroquine, Methotrexate, Sulfasalazine and Prednisone of unknown dose and frequency, but no relief was provided. Details of concomitant medications, medical history, clinical course and treatment were not provided. The event has not resolved at the time of the report. The benefit-risk relationship of mRNA-1273 is not affected by this report. Events' seriousness retained as per Important Medical Event List.