Struggling to breathe/ difficulty breathing; Acute inflammatory response; Chest tightness; Fever; Rash; Swollen lymph nodes on her neck, arm pit; Throat was hurting; Vomiting/ Felt like throwing up; Very nauseous; Feel ill; Body aches; Muscle aches; Not sleeping; Chills; Headache; This is a spontaneous report  from a contactable consumer (patient) and another consumer (Patient's spouse). A 26-years-old female patient received bnt162b2 (COMIRNATY), dose 1 via an unspecified route of administration, administered in Arm Left on 24Sep2021 13:00 (Lot Number: FC3183) at age of 26 years old as DOSE 1, SINGLE for covid-19 immunisation.  Medical history included hypothyroidism from 2017 and ongoing About 4 years ago. There were no concomitant medications.  On the first day after her dose of the vaccine the patient started having a headache, on the second day she began having fever and chills. She developed a rash and had swollen lymph nodes on her neck, arm pit, and stomach which has not gone down. The patient said her fevers only got a little better with the use of Tylenol. She tested again for covid after these symptoms began and the test came back negative. Patient was also tested for mono and strep, which were negative. She "kept getting worse" and her "throat was hurting, very nauseous, vomiting, not sleeping, very off" and she went to the ER "first where they ran "a lot of tests on her, a ton; everything came back negative". Patient had a CT scan that showed her "lymph nodes were swollen all over" and that it was "not viral". She followed up as directed with a hematologist, "like a cancer doctor" and was told it was "not cancer". Patient was still continuing to feel ill with fever, chills, felt like throwing up, couldn't drink water, and was admitted again. While there "they ran a lot more tests, those coming out negative". Patient was told her symptoms are "possibly a reaction to the vaccine" and her body is experiencing "an acute inflammatory response". Patient was "hospitalized for a couple of days". Patient had been through a lot of blood tests, scans, MRIs, all is pointing to the vaccine. After the hospitalization she saw specialists including a rheumatologist and an infectious disease specialist. Not all of her labs have resulted and she still needs to follow up. This has been going on six weeks. Patient tested negative for covid before receiving her first dose of the vaccine. The spouse mentions they both got the vaccine. However, his wife started seeing continuous symptoms. She kept getting fever, chills, body aches, muscle aches, chest tightness, her lymph nodes swollen. His wife developed rashes. This happened 3-4 weeks on and off. They continued to monitor her because it was bad. They didn't know what was going on and they were trying different things. They used Tylenol and Ibuprofen to medicate the effects of the fever. She had three or four weeks of consistent fevers. Her fevers were so bad she had to use Tylenol multiple times a day as a way to find somewhat of relief. It got worse. Before this, she had to take Tylenol once a day. She had fever and chills once a day which was more manageable but still weird. The rashes were pretty bad, but the rashes stopped around 3-4 weeks into it. She continued to have the fever, chills. Then, she had nausea and she didn't want to eat. She couldn't eat at all. They were getting really concerned but they couldn't keep feeding her Tylenol because it was starting to mess her up. Then, they had to do severe chest compressions because she was struggling to breathe She had to be rushed to the ER. She was seen in the ER at one place locally. However, they couldn't figure out what was going on. He states she was in the hospital just during the day and decided to take her out. Her symptoms started continuing again the next day so they decided to take her to a different ER because she kept getting worse. She was taken to the hospital where her father works in. She was hospitalized there for about 4 or 5 days. They did so many different tests and everything. None of the doctors could figure out what was going on and were knocking out all the possibilities. She was referred to a Rheumatologist, a specialist in Autoimmune Diseases to see what was going on. The first thought was that it was a reaction to the Pfizer vaccination, which no doctors could help with that. They took a couple more test. Once the test started coming back, they were able to get his wife stable. There was a constant use of IV's and Tylenol and she was on watch 24/7. Tests were done. They believed it was a direct result of Pfizer's COVID-19 vaccine. They have taken her out of the hospital and she is doing a lot better. Her fever has subsided since her visit to the second hospital. However, they are still monitoring her and his wife is still having side effects and reactions to the smallest things. It's nothing alarming like difficulty breathing, fever, chills or that kind of thing. He clarified the date of the second hospitalization is 02Nov2021 to 07Nov2021. He confirms she was discharged this past Sunday, 07Nov2021. The outcome of event fever was recovered, rash was recovered in 2021, and others was not recovered.