The Second Covid Booster her arm swelled even more with enormous hives.; hives; pain; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP) from medical information team. The reporter is the patient.  A 71-year-old female patient received BNT162b2 (BNT162B2), on 21Apr2022 as dose 4 (booster), 0.3 ml single (Lot number: FK9894) at the age of 71 years, in left arm for covid-19 immunisation. The patient's relevant medical history included: "COVID", start date: 01Jan2021 (unspecified if ongoing), notes: She initially provided she had COVID 01Jan2020, but clarified it was 01Jan2021. She herself had a headache for only one night, but doctor insisted she be tested and she had COVID. She had no other symptoms other than headache one night and a low grade temperature.; "Cancer" (unspecified if ongoing), notes: she had cancer and lymph nodes in both arms.; "Lymph nodes removed", start date: Nov2019, stop date: Nov2019, notes: The lymph nodes removed Nov2019; "Estrogen blocker prevent cancer coming back" (ongoing), notes: Estrogen blocker prevent cancer coming back; "Heartburn" (ongoing). Concomitant medication(s) included: LETROZOLE taken for prophylaxis (ongoing); ESOMEPRAZOLE MAGNESIUM taken for dyspepsia (ongoing). Vaccination history included: BNT162b2 (DOSE 3 (BOOSTER), 0.3 ML SINGLE, Batch/lot number: EW0187, Dosage text: .3ml administered in arm; unknown which one, Reaction / Event as Reported by the Primary Source for Translation:First Covid), administration date: 11Oct2021, when the patient was 70-year-old, for COVID-19 immunization, reaction(s): "Hives"; BNT162b2 (DOSE 3 (BOOSTER), 0.3 ML SINGLE, Batch/lot number: EW0187, Dosage text: .3ml administered in arm; unknown which one), administration date: 11Oct2021, when the patient was 70-year-old, for COVID-19 Immunization, reaction(s): "pain"; Covid-19 vaccine (Dose 1 , Unknown Manufacturer), for COVID-19 Immunization; Covid-19 vaccine (Dose 2 , Unknown Manufacturer), for COVID-19 Immunization. The following information was reported: URTICARIA (non-serious) with onset Apr2022, outcome "unknown", described as "hives"; PAIN (non-serious) with onset Apr2022, outcome "unknown"; PERIPHERAL SWELLING (non-serious) with onset 22Apr2022, outcome "unknown", described as "The Second Covid Booster her arm swelled even more with enormous hives.". Relevant laboratory tests and procedures are available in the appropriate section.  Additional information: Caller mentioned that she had Pfizer for all of her previous Covid-19 vaccine shots. She had her lymph nodes removed. She was afraid of experiencing lymphadenopathy. she mentioned that she was currently on physical therapy and still experiences pain. Her family care doctor told her to contact Pfizer and tell her if she should still get another booster. Other Conditions and Other Products: Yes. Initially provided she had cancer and lymph nodes in both arms. The second booster, clarified and confirmed as Pfizer. The second COVID Booster her arm swelled even more with enormous hives. Both her and her doctor are afraid of lymphoma. Reporter indicated she was unsure if she reported this to our safety department. Explained, she went on our website which was confusing. She was reading multiple things. She went on to a contact us section and it allowed her to type her information in 500 words or less. She described what happened and was asking for advice. Now she's afraid of getting another booster shot after the reactions she has had. She never received any comments or feedback from us after the submission of details. She confirmed she was not provided with any type of reference number. Therefore, report marked as initial. Started physical therapy and it was helping. Her physical therapist told her he thought the shot that was given in the muscle swelled and pressed on the sciatic nerve which just got worse from there. She added, her physical therapist told her they had three other people come in who had the injection in their arm and had pain for a month long and they were working with them. She's the fourth one with pain. Other Conditions: Reporter later clarified details. She had cancer that had spread to the lymph nodes in both arms. Both of those lymph nodes were removed. The lymph nodes were removed Nov2019. She also added, before any vaccine her husband had COVID. She herself had a headache for only one night, but doctor insisted she be tested and she had COVID. She had no other symptoms other than headache one night and a low grade temperature. She initially provided she had COVID 01Jan2020, but clarified it was 01Jan2021. Investigation: Doctor always checks cholesterol, but no details provided. Declined to continue with report. Wanted to get over to medical information. There is a product complaint to report. Description of Product Complaint: Description of complaint: This is a PC on treatment medications and not the suspect products mentioned during interaction. rednisone and Aleve did not work. Prednisone and Aleve lot and exp are unknown to reporter. Does not have details to provide. Product strength and count size dispensed: Not provided, Additional lot numbers: None. Is a sample of the product available to be returned, if requested (Y/N): Not provided. Packaging sealed and intact? Not provided.