Hand swelling; General body pain; Condition aggravated; Joint range of motion decreased; Limbs stiffness; Weakness of upper extremities; Condition aggravated; Hand pain; Numbness of upper extremities; Fall; Pinched nerve; This spontaneous case was reported by a consumer and describes the occurrence of MUSCULAR WEAKNESS (Weakness of upper extremities), the first episode of CONDITION AGGRAVATED (Condition aggravated), PERIPHERAL SWELLING (Hand swelling), PAIN (General body pain) and FALL (Fall) in an 80-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.    Co-suspect product included non-company product UPADACITINIB (RINVOQ) for an unknown indication.    No Medical History information was reported.   In November 2021, the patient received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On an unknown date, the patient started UPADACITINIB (RINVOQ) (Oral) at an unspecified dose. In 2021, the patient experienced FALL (Fall), NERVE COMPRESSION (Pinched nerve) and HYPOAESTHESIA (Numbness of upper extremities). In November 2021, the patient experienced MUSCULAR WEAKNESS (Weakness of upper extremities), the first episode of CONDITION AGGRAVATED (Condition aggravated) and PAIN IN EXTREMITY (Hand pain). On an unknown date, the patient experienced PERIPHERAL SWELLING (Hand swelling), PAIN (General body pain), the second episode of CONDITION AGGRAVATED (Condition aggravated), JOINT RANGE OF MOTION DECREASED (Joint range of motion decreased) and MUSCULOSKELETAL STIFFNESS (Limbs stiffness). The patient was treated with PREDNISONE at a dose of for 14 to 28 days; PARACETAMOL (TYLENOL) for Pain, at an unspecified dose and frequency and IBUPROFEN for Pain, at an unspecified dose and frequency. At the time of the report, MUSCULAR WEAKNESS (Weakness of upper extremities) and PAIN IN EXTREMITY (Hand pain) had not resolved, PERIPHERAL SWELLING (Hand swelling), PAIN (General body pain), FALL (Fall), NERVE COMPRESSION (Pinched nerve), JOINT RANGE OF MOTION DECREASED (Joint range of motion decreased), MUSCULOSKELETAL STIFFNESS (Limbs stiffness) and HYPOAESTHESIA (Numbness of upper extremities) outcome was unknown and last episode of CONDITION AGGRAVATED (Condition aggravated) had resolved.        The action taken with mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) was unknown.       Concomitant medications were not reported.  The patient was treated with IBUPROFEN, TYLENOL and PREDNISONE.  The reporter's causality with Rinvoq for the event(s) of weakness from wrist to finger tips, flare ups onset in November 2021, hand pain at night, swelling in hands at night, body pain, fall and had possible pinch nerve onset in 2021, fall and had possible pinch nerve onset in 2021, arm numbness, flare up with hand/hand could not close unknown onset, flare up with hand/hand could not close unknown onset, right hand stiff, right hand painful and flare ups onset in April 2022 was not provided.  This case was identified as part of a retrospective clean-up activity where certain emails received in the Moderna mailbox were missed to be booked-in   Most recent FOLLOW-UP information incorporated above includes: On 20-Apr-2022: Significant follow-up : Event added- Limbs stiffness