My periods are messed up; had the worst cramps; excruciating crippling pain; this was worse than anything I've ever felt; Now I have stopped getting my period; my last period only lasted maybe half a day or a day; Booster; This is a spontaneous report received from a contactable reporter(s) (Other HCP). The reporter is the patient.  A 32 year-old female patient (not pregnant) received bnt162b2 (BNT162B2), administered in arm left, administration date 24Aug2021 (Lot number: FC3180) at the age of 32 years as dose 3 (booster), single for covid-19 immunisation. Relevant medical history included: "Intermittent Cushing's syndrome reoccurence" (unspecified if ongoing); "Known allergies: Gluten" (unspecified if ongoing); "COVID-19" (unspecified if ongoing), notes: if covid prior vaccination: Yes; "Addison's disease due to bilateral adrenalectomy" (unspecified if ongoing); "vulvodynia" (unspecified if ongoing); "chronic pelvic pain" (unspecified if ongoing); "Addison's disease due to bilateral adrenalectomy" (unspecified if ongoing); "birth control" (unspecified if ongoing), notes: 21years don't remember ever missing a period except for on birth control I am not currently on any.; "pityriasis rosea" (unspecified if ongoing), notes: flareup pityriasis rosea when my second injection in feb. last time virus was 10 years ago or more. Concomitant medication(s) included: HYDROCORTISONE; FLUDROCORTISONE; PERCOCET [OXYCODONE HYDROCHLORIDE;OXYCODONE TEREPHTHALATE;PARACETAMOL]. Past drug history included: Augmentin, reaction(s): "Known allergies: Augmentin". Vaccination history included: Bnt162b2 (Dose no 2 Batch/Lot No: 14364 location of injection: Arm Left), administration date: 15Feb2021, when the patient was 31 years old, for COVID-19 immunization, reaction(s): "had the worst cramps"; Bnt162b2 (Dose no:1 Batch/Lot No 14165Location of injection: Arm Left), administration date: 25Jan2021, when the patient was 31 years old, for Covid-19 immunisation; Bnt162b2 (DOSE: 2), administration date: 15Feb2021, when the patient was 31 years old, for COVID-19 Immunization, reaction(s): "My periods are messed up", "excruciating crippling pain", "this was worse than anything I've ever felt"; Bnt162b2 (DOSE: 2), administration date: 15Feb2021, when the patient was 31 years old, for COVID-19 Imuunization, reaction(s): "flare up of pityriasis rosea". The following information was reported: IMMUNISATION (non-serious) with onset 24Aug2021, outcome "unknown", described as "Booster"; MENSTRUATION IRREGULAR (non-serious), outcome "not recovered", described as "My periods are messed up"; DYSMENORRHOEA (non-serious), outcome "not recovered", described as "had the worst cramps"; PAIN (non-serious), outcome "not recovered", described as "excruciating crippling pain"; CONDITION AGGRAVATED (non-serious), outcome "not recovered", described as "this was worse than anything I've ever felt"; AMENORRHOEA (non-serious), outcome "not recovered", described as "Now I have stopped getting my period"; MENSTRUAL DISORDER (non-serious), outcome "not recovered", described as "my last period only lasted maybe half a day or a day". Therapeutic measures were not taken as a result of menstruation irregular, dysmenorrhoea, pain, condition aggravated, amenorrhoea, menstrual disorder. her periods are messed up. she had the worst cramps she ever felt in her life excruciating crippling pain, and she typically take prescription painkillers for period pain and this was worse than anything she have ever felt. Now she had stopped getting period. In 21 years she don't remember ever missing a period except for on birth control and she was not currently on any. She didn't got a period for Jan at all and her last period only lasted maybe half a day or a day in Dec. she also had a flareup of pityriasis rosea when had her second injection in Feb. The last time she had that virus was 10 years ago or more. It coincided with her vaccine. she was very concerned, multiple her friends have stated they completely lost their period.   Follow-Up (01Feb2022): Follow-up attempts are completed. No further information is expected.