encephalitis; fatigue; pain in the injection site; body ache; chills; He had fever and it was so bad; head was hurting/extreme headache; his arm was hurting so bad; arm was hurting so bad, that he could not sleep/long insomnia; could not lift his arm; He felt irritate; goofy/He was heard crying in the call.; the pain was so bad that he was screaming and yelling. The pain was better after his movie but it progressively got worse.; This spontaneous case was reported by a consumer and describes the occurrence of ENCEPHALITIS (encephalitis), PAIN IN EXTREMITY (his arm was hurting so bad), INSOMNIA (arm was hurting so bad, that he could not sleep/long insomnia), LIMB DISCOMFORT (could not lift his arm) and IRRITABILITY (He felt irritate) in a 29-year-old male patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for an unknown indication. The occurrence of additional non-serious events is detailed below.     The patient's past medical history included COVID-19. Concurrent medical conditions included Anxiety, Depression and ADHD (he may have ADHD but the psychiatrist refused to diagnose him). Concomitant products included SERTRALINE HYDROCHLORIDE (ZOLOFT) for Depression.   On 19-Dec-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 26-Jan-2022 at 9:00 AM, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. On 26-Jan-2022, the patient experienced PAIN IN EXTREMITY (his arm was hurting so bad), INSOMNIA (arm was hurting so bad, that he could not sleep/long insomnia), LIMB DISCOMFORT (could not lift his arm), IRRITABILITY (He felt irritate), FEELING ABNORMAL (goofy/He was heard crying in the call.), PAIN (the pain was so bad that he was screaming and yelling. The pain was better after his movie but it progressively got worse.), PYREXIA (He had fever and it was so bad) and HEADACHE (head was hurting/extreme headache). On an unknown date, the patient experienced ENCEPHALITIS (encephalitis), FATIGUE (fatigue), VACCINATION SITE PAIN (pain in the injection site), MYALGIA (body ache) and CHILLS (chills). The patient was treated with CAFFEINE (oral) ongoing since an unknown date at an unspecified dose and frequency; BETA-ALANINE (oral) ongoing since an unknown date at an unspecified dose and frequency; CITRULLINE ongoing since an unknown date at an unspecified dose and frequency and PARACETAMOL (TYLENOL [PARACETAMOL]) at an unspecified dose and frequency. At the time of the report, ENCEPHALITIS (encephalitis), PAIN IN EXTREMITY (his arm was hurting so bad), INSOMNIA (arm was hurting so bad, that he could not sleep/long insomnia), LIMB DISCOMFORT (could not lift his arm), IRRITABILITY (He felt irritate), FEELING ABNORMAL (goofy/He was heard crying in the call.), PAIN (the pain was so bad that he was screaming and yelling. The pain was better after his movie but it progressively got worse.), FATIGUE (fatigue), VACCINATION SITE PAIN (pain in the injection site), MYALGIA (body ache), CHILLS (chills), PYREXIA (He had fever and it was so bad) and HEADACHE (head was hurting/extreme headache) outcome was unknown.            It was mentioned that patient stated that he got COVID-19 and before of that he had a lot of side effects.  Patient received the vaccine at 9am and went to work at about 4 o'clock in the afternoon. The symptoms started then. The pain was better after his movie but it progressively got worse.  Reporter stated he was drinking a lot of caffeine and beta-alanine (as part of his routine and his body should be used to it by now), citrulline and the last year he was taking Zoloft (anti-depressant). Also he was taking Tylenol. He thought that all these symptoms are related to the management of pesticides. He wanted to know if there was any correlation between the coronavirus and the coronavirus.  Company Comment: This case concerns a 29-year-old male patient, with relevant medical history of COVID-19, Anxiety and Depression, who experienced the unexpected events of Encephalitis (not medically confirmed), Pain in extremity, Insomnia, Limb discomfort, Irritability, Feeling abnormal, Pain, and the expected events of Pyrexia, Headache, Fatigue, Vaccination site pain, Myalgia and Chills. The events occurred on the same day after receiving the second dose of mRNA-1273 Vaccine. At the time of the report the outcome of the events was unknown. The patient's medical history of  COVID-19, Anxiety and Depression, remain as confounders for the occurrence of the events. The benefit-risk relationship of mRNA-1273 Vaccine is not affected by this report.   Most recent FOLLOW-UP information incorporated above includes: On 27-Jan-2022: Follow-up information included case upgraded to serious, reporter address updated, concomitant medication, New events and treatment medication added.; Sender's Comments: This case concerns a 29-year-old male patient, with relevant medical history of COVID-19, Anxiety and Depression, who experienced the unexpected events of Encephalitis (not medically confirmed), Pain in extremity, Insomnia, Limb discomfort, Irritability, Feeling abnormal, Pain, and the expected events of Pyrexia, Headache, Fatigue, Vaccination site pain, Myalgia and Chills. The events occurred on the same day after receiving the second dose of mRNA-1273 Vaccine. At the time of the report the outcome of the events was unknown. The patient's medical history of  COVID-19, Anxiety and Depression, remain as confounders for the occurrence of the events. The benefit-risk relationship of mRNA-1273 Vaccine is not affected by this report.