weakness; loss of apetite / poor appetite; Auto Immune disorder with an ANA marker; over inflated lungs; low white count; arm pain; Postherpetic Neuralgia; Nerve damage; barely move her arm and; tingling sensa; most of the pain radiates from the injection site; frozen shoulder; rash; non-stop coughing; chills; headache; chest pain; tickle in the back of her throat; extremely lethargic/ lethargy got worse; This case was reported by a consumer and described the occurrence of weakness in a female patient who received Herpes zoster (Shingrix) for prophylaxis.   In February 2019, the patient received the 1st dose of Shingrix. In February 2019, less than a month after receiving Shingrix, the patient experienced appetite lost (serious criteria hospitalization), rash, cough, chills, headache, chest pain, local throat irritation and lethargy. On an unknown date, the patient experienced weakness (serious criteria hospitalization), autoimmune disorder (serious criteria GSK medically significant), lung disorder, decreased white cell count, pain in arm, post herpetic neuralgia, nerve damage, mobility decreased, tingling sensation, injection site pain and frozen shoulder. The patient was treated with antibiotics nos (Antibiotics (Brand Names Not Known)), hydrocodone bitartrate + paracetamol (Vicodin) and gabapentin. On an unknown date, the outcome of the weakness, appetite lost, autoimmune disorder, rash, chills, headache, chest pain, local throat irritation, lethargy, lung disorder, decreased white cell count, pain in arm, post herpetic neuralgia, nerve damage, mobility decreased, tingling sensation, injection site pain and frozen shoulder were unknown and the outcome of the cough was recovered/resolved.   It was unknown if the reporter considered the weakness, appetite lost, autoimmune disorder, rash, cough, chills, headache, chest pain, local throat irritation, lethargy, lung disorder, decreased white cell count, pain in arm, post herpetic neuralgia, nerve damage, mobility decreased, tingling sensation, injection site pain and frozen shoulder to be related to Shingrix.  Additional details were reported as follows: The age at vaccination was not reported. The patient went to the second week of February 2019 and received the first dose of the Shingrix vaccine. She started having side effects right away, she started with a rash, non stop coughing which lasted months, chills, headaches, chest pain, loss of appetite, constant tickle in the back of her throat and extremely lethargic. She went to her primary care physician who performed numerous blood tests. She went to a cardiologist and they did a chest X ray where they found that she had over inflated lungs. They gave her antibiotics and it did nothing for her symptoms. They put her on bed rest for 4 weeks and it still did nothing. When they tested her blood they found that she had an auto Immune disorder with an antinuclear antibody marker with an extremely low white count. They tested her for AIDS, Lupus, Lyme Disease. All came back negative. The lethargy got worse and was admitted to the hospital for weakness and poor appetite. They did magnetic resonance imaging , computerised tomogram scan and all came back clear. During all this patient also had arm pain which got worse over time. It was now to the point where she was taking pain pills (Vicodin) on a daily basis to help relive the pain. She was recently diagnosed with postherpetic neuralgia and was given gabapentin to help with the nerve damage. She can barely move her arm and most of the pain radiates from the injection site and had a tingling sensation. She had frozen shoulder and had surgery to repair the frozen shoulder to release scar tissue. She just had a recent magnetic resonance imaging and the frozen shoulder had come back and will need another surgery.  She has seen a cardiologist, oncologist, rheumatologist, hematologist. The reporter asked whether these reactions experienced by any other patients.