This spontaneous case was reported by a consumer and describes the occurrence of URTICARIA (Very severe case of hives), FEELING ABNORMAL (Hands would be so irritated by itching that it was very uncomfortable), OROPHARYNGEAL DISCOMFORT (Feels something is going on in his throat, like something's pushing back), ILLNESS (Sick [after booster dose]) and HEAD DISCOMFORT (Bugging in my head) in a 48-year-old male patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 027H21B, 007B21A and 003C21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below. No Medical History information was reported. On 26-Mar-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form.On 30-Apr-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. On 20-Nov-2021, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. In November 2021, the patient experienced ILLNESS (Sick [after booster dose]), HEAD DISCOMFORT (Bugging in my head) and PYREXIA (Fever). On 02-Dec-2021, the patient experienced URTICARIA (Very severe case of hives). On 04-Dec-2021, the patient experienced OROPHARYNGEAL DISCOMFORT (Feels something is going on in his throat, like something's pushing back). In December 2021, the patient experienced FEELING ABNORMAL (Hands would be so irritated by itching that it was very uncomfortable), PRURITUS (Itchy in my feet/ groin area), DISTURBANCE IN ATTENTION (Difficult to focus on anything), SKIN DISCOLOURATION (Discoloration) and INFLAMMATION (Hands were very inflamed). On an unknown date, the patient experienced DYSPEPSIA (Terrible indigestion) and PHARYNGEAL SWELLING (Throat or esophagus is swollen). The patient was treated with FEXOFENADINE HYDROCHLORIDE (ALLEGRA [FEXOFENADINE HYDROCHLORIDE]) for Adverse event, at an unspecified dose and frequency; DIPHENHYDRAMINE HYDROCHLORIDE (BENADRYL [DIPHENHYDRAMINE HYDROCHLORIDE]) for Adverse event, at an unspecified dose and frequency; CLARITHROMYCIN (CLARITIN [CLARITHROMYCIN]) for Adverse event, at an unspecified dose and frequency; CETIRIZINE HYDROCHLORIDE (ZYRTEC [CETIRIZINE HYDROCHLORIDE]) ongoing since an unknown date for Adverse event, at an unspecified dose and frequency; OMEPRAZOLE (PRILOSEC [OMEPRAZOLE]) ongoing since an unknown date for Adverse event, at an unspecified dose and frequency; FAMOTIDINE (PEPCID [FAMOTIDINE]) ongoing since an unknown date for Adverse event, at an unspecified dose and frequency and CALAMINE, GLYCEROL, ZINC OXIDE (CALAMINE LOTION) for Adverse event, at an unspecified dose and frequency. At the time of the report, URTICARIA (Very severe case of hives), FEELING ABNORMAL (Hands would be so irritated by itching that it was very uncomfortable) and OROPHARYNGEAL DISCOMFORT (Feels something is going on in his throat, like something's pushing back) had not resolved and ILLNESS (Sick [after booster dose]), HEAD DISCOMFORT (Bugging in my head), PRURITUS (Itchy in my feet/ groin area), DISTURBANCE IN ATTENTION (Difficult to focus on anything), SKIN DISCOLOURATION (Discoloration), INFLAMMATION (Hands were very inflamed), DYSPEPSIA (Terrible indigestion), PHARYNGEAL SWELLING (Throat or esophagus is swollen) and PYREXIA (Fever) outcome was unknown. For mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular), the reporter did not provide any causality assessments. The patient had never had a history of indigestion or problems eating. No concomitant medications was reported. This case was linked to MOD-2022-440948 (Patient Link).