This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP). The reporter is the patient. Other Case identifier(s): MOD22-022163 (Moderna). A female patient received BNT162b2 (BNT162B2), on 20Nov2021 as dose 3 (booster), single (Lot number: FH8028) for covid-19 immunisation; elasomeran (MODERNA COVID-19 VACCINE), on 08Aug2022 as dose 4 (booster), single (Lot number: 014B22A) for covid-19 immunisation. The patient's relevant medical history included: "Thyroid" (unspecified if ongoing). Concomitant medication(s) included: LEVOTHYROXINE taken for thyroid disorder. Past drug history included: Cortisone, reaction(s): "Allergies (medications, food and other products) Cortisone", notes: Allergies (medications, food and other products) Cortisone. Vaccination history included: BNT162b2 (Dose 1, Single; Lot number: EN6208), administration date: 10Mar2021, for Covid-19 immunization; BNT162b2 (Dose 2, Single; Lot number: ER8737), administration date: 31Mar2021, for Covid-19 immunization. The following information was reported: PRURITUS (medically significant) with onset 10Aug2022, outcome "recovered" (12Aug2022), described as "Itching in the feet"; DYSPEPSIA (medically significant) with onset 10Aug2022, outcome "not recovered", described as "felt like heart burn"; CHEST DISCOMFORT (medically significant) with onset 10Aug2022, outcome "not recovered", described as "pressure in her chest"; ERYTHEMA (medically significant) with onset 10Aug2022, outcome "recovered" (12Aug2022), described as "redness in the hands"; DYSPNOEA (medically significant) with onset 10Aug2022, outcome "not recovered", described as "she had trouble breathing"; PRURITUS (medically significant) with onset 10Aug2022, outcome "recovered" (12Aug2022), described as "skin itching in the bottom of her hand"; PERIPHERAL SWELLING (medically significant), PERIPHERAL SWELLING (medically significant) all with onset 10Aug2022, outcome "recovered" (12Aug2022) and all described as "swollen hands/feet also started and were swelled"; DRY SKIN (medically significant) with onset 12Aug2022, outcome "not recovered", described as "patient still felt dry skin even if it wasn't because she moisturized her it". The events "swollen hands/feet also started and were swelled", "she had trouble breathing", "felt like heart burn", "pressure in her chest", "patient still felt dry skin even if it wasn't because she moisturized her it", "skin itching in the bottom of her hand", "itching in the feet" and "redness in the hands" required physician office visit. Therapeutic measures were taken as a result of peripheral swelling, peripheral swelling, dyspnoea, dyspepsia, chest discomfort, dry skin, pruritus, pruritus, erythema. Clinical course: Patient received treatment with Benadryl, a nebulizer and an inhaler Albuterol. Itchiness stopped 36 hours after it started, but patient still felt skin dry even if it was not because moisturized it. In Jan2022, patient had COVID. Had no any medical history relating to mentioned AE and both Acute and Chronic illnesses at the time of vaccination. Patient did not experienced a similar event in the past. No follow-up attempts are possible. No further information is expected.