chronic urticaria; hives; inflammation; feels like the skin is burning; This spontaneous case was reported by a consumer and describes the occurrence of URTICARIA CHRONIC (chronic urticaria), URTICARIA (hives), INFLAMMATION (inflammation) and SKIN BURNING SENSATION (feels like the skin is burning) in a female patient of an unknown age who received mRNA-1273 BIVALENT .222 (MODERNA COVID-19 VACCINE, BIVALENT (ORIGINAL AND OMICRON BA.4/BA.5)) (batch no. A57162B) for COVID-19 prophylaxis.     No Medical History information was reported.    On 21-Sep-2022, the patient received fifth dose of mRNA-1273 BIVALENT .222 (MODERNA COVID-19 VACCINE, BIVALENT (ORIGINAL AND OMICRON BA.4/BA.5)) (unknown route) 1 dosage form. In February 2023, the patient experienced URTICARIA CHRONIC (chronic urticaria), URTICARIA (hives), INFLAMMATION (inflammation) and SKIN BURNING SENSATION (feels like the skin is burning). The patient was treated with FEXOFENADINE HYDROCHLORIDE (ALLEGRA [FEXOFENADINE HYDROCHLORIDE]) at a dose of UNK, qd. At the time of the report, URTICARIA CHRONIC (chronic urticaria), URTICARIA (hives), INFLAMMATION (inflammation) and SKIN BURNING SENSATION (feels like the skin is burning) had not resolved.        For mRNA-1273 BIVALENT .222 (MODERNA COVID-19 VACCINE, BIVALENT (ORIGINAL AND OMICRON BA.4/BA.5)) (Unknown), the reporter did not provide any causality assessments.   No concomitant medications were reported.  Patient's previous vaccination details: On 26-Mar-2021, patient received 1st dose of moderna vaccine with batch/lot number: 007h21a. On 29-Apr-2021, patient received 2nd dose with batch/lot number: 009c21a. On 01-Nov-2021, 3rd dose of moderna vaccine with batch/lot number: 012f21a.  On 29-apr-2022, patient received 4th dose of moderna vaccine with batch/lot number: 056a22a.  Patient started to present symptoms around Feb 2023 "estimated": chronic urticaria or hives, the symptoms are ongoing, symptoms are the same, if the largest organ is the skin, it is in the chronic category, inflammation is very bad for the body, patient was forced to use the Allegra hives every day, it feels like the skin was burning, type of hives that feels like pressure to the skin, skin immediately reacts if was in under pressure or under stress hives appears, patient thought it is a side effect of the Moderna COVID19 vaccine. Doctor suggested "the brand-new Allegra hives, which the patient stated, "has a theory" and stated the following: Moderna was very much aware of the side effects, and you know that's fine. During this very unusual circumstance a pandemic can't come up with something perfect the first or second or even third time, so will have side effects. And patient was realized that but it's more than a coincidence that the makers the manufacturers, their pharmaceutical company. Behind Allegra hides issued this medication at the same time when the Moderna vaccines and boosters are out. There are no coincidence Allegra hides has been issued. And patient have to say that it certainly helps. So patient was taking it, It's an over-the-counter medication. No other medication associated with the hives.  The symptoms are the same and if don't take the Allegra Hives, the largest organ of the human body being the skin was irritated. To the point where it was in the chronic category and patient don't want that Inflammation to be an ongoing because that information is very, very bad for the body. Long term. So patient was forced to use the Allegra Hives every day. If doesn't take It gets to the point where it almost feels like the skin was burning.  Where if pressure is applied to the skin the skin immediately visually reacts where if scratch myself very lightly, the dog was jumped on me and brush myself against drawer or it's on the scalp a visual wealth will appear if under pressure or under stress. Little wealth will appear all over the body. Patient suspected again that it was the effect a side effect from the Moderna is either the booster or the vaccine.    Most recent FOLLOW-UP information incorporated above includes: On 06-Sep-2023: Non-Significant information received: reference numbers were added.