his appendix rupturing; This is a spontaneous report from a contactable consumer (Patient) via professional Pfizer sponsored program. A 58-years-old male patient received bnt162b2 (PFIZER-BIONTECH COVID-19 VACCINE, solution for injection, Lot number was not reported), via an unspecified route of administration, administered in Arm Right in Apr2021 (Age at vaccination: 58 years) as dose 1, single for covid-19 immunization. Patient states that he received the 1st dose of the Pfizer covid-19 vaccine either 08Apr2021 or 09Apr2021. Medical history included ongoing high blood pressure(Onset about 3.5 years ago) , ongoing high cholesterol, ongoing rheumatoid arthritis. Concomitant medications included secukinumab (COSENTYX SENSOREADY) 150mg/mL sensor ready pen once monthly in right thigh taken for rheumatoid arthritis from 2019 (Start date about 2 years ago) to an unspecified stop date, METHOTREXATE SODIUM 2.5mg tablets-6 tablets once a week taken for rheumatoid arthritis from 2019 (Start about 1.5 years ago.Discard after 01Dec2022) to an unspecified stop date, dapagliflozin propanediol monohydrate (FARXIGA) 20/12.5mg tablet daily taken for an unspecified indication from 2018 (Start probably 3 years ago) to an unspecified stop date, lisinopril dihydrate (LISINOPRIL ACOST) 20/12.5 mg tablet daily taken for High blood pressure Start probably 3-3.5 years ago, start and stop date were not reported, ATORVASTATIN CALCIUM 20mg tablet taken for blood cholesterol increased from 2018 (Start about 3.5 years ago) to an unspecified stop date, folic acid (FOLIC ACID ALMUS) 1mg daily taken for an unspecified indication from 2019 (Start about 2 years ago) to an unspecified stop date Vitamin supplement, thioctic acid, ubidecarenone (COENZYME Q10 + ALIPOIC ACID) 400mg daily taken for an unspecified indication from 2019(Start about 2 years ago) to an unspecified stop date as Vitamin supplement, colecalciferol (VITAMIN D 3) 1000IUs-1 tablet daily taken for an unspecified indication from 2019 (Start about 2 years ago) to an unspecified stop date Vitamin supplement, fish oil (FISH OIL) 1000mg taken for an unspecified indication from 2019 (2 years ago) to an unspecified stop date as a vitamin supplement, VITAMIN B COMPLEX (Super B Complex) taken for an unspecified indication from 2019 (Start about 2 years ago) to an unspecified stop date as avitamin supplement, acetylsalicylic acid (ASPIRIN (E.C.)) (Low-dose Baby) Aspirin 81mg tablet taken for an unspecified indication, start and stop date were not reported. The patient experienced his appendix rupturing on 24Apr2021. Onset time was unknown. He was having a cable line placed and was feeling sick 24Apr2021; later that day ate dinner and wasn't feeling well at all. He got real sick that night and the next day. He was drinking water for 3 days and thought maybe he had a stomach flu but he did not. He was admitted to the hospital where he was diagnosed with ruptured appendix, apparently appendix blew up inside him. Because of that he had surgery and they put a tube in and it was draining for 2 weeks. When he was discharged home he made mistake of not asking if he should take his medications or not; so he restarted his Cosentyx and Methotrexate which compromised his immune system, hurt his immune system; kept him from recovering as fast so he relapsed about 3 weeks after the surgery; not really bad but enough to go get antibiotics. When he saw his Rheumatologist they said he needed to stop taking Cosentyx and Methotrexate until the surgeon clears him to restart those products. he was cleared by the surgeon to restart them yesterday, but it going to wait to restart until seeing his Rheumatologist as advised by surgeon. He is much better now, just left the surgeon's office 12Jul2021. In Aug2021 he goes in for a CT Scan to see if they need to go in a remove any parts. Treatment: Antibiotics: Initially started on Metronidazole 500mg 1 tablet by mouth every 8 hours daily and Ciprofloxacin 500mg tablet by mouth 2 times daily. After the Ciprofloxacin was no longer working they had him start taking Amoxicillin twice daily for 10 days. They took culture growth of the wound and saw his body was not accepting the Ciprofloxacin anymore so changed him to Amoxicillin. Regarding testing investigations information he advised that withheld, General Surgery/MD/FACS be called for that information at: withheld, Fax: withheld and if need to talk to withheld who is the doctor's personal secretary nurse lady. He can give blood information because he had blood test done, no urine test done last time caller was there; and withheld did the blood culture from him, he did the growth culture growth on the wound. He states that he was able to "take other medication but they have just gave him clearance" for him to go ahead and get his 2nd dose of the vaccine, however they were not sure if he would just get the 2nd dose or if his series needed to be restarted due to it being a 70+ day time lapse. His question today is does he have to start over with the first shot or can he get his 2nd shot.The patient was hospitalized for his appendix rupturing from 03May2021 to 07Jul2021. Advised reporter regarding the additional dose information pertaining to the latest press release from Pfizer. While Pfizer and BioNTech believe a third dose of BNT162b2 has the potential to preserve the highest levels of protective efficacy against all currently known variants including Delta, the companies are remaining vigilant and are developing an updated version of the Pfizer-BioNTech COVID-19 vaccine that targets the full spike protein of the Delta variant. The first batch of the mRNA for the trial has already been manufactured. The Companies anticipate the clinical studies to begin in August, subject to regulatory approvals. Onset about 2.5 years ago. He had inflamed finger and they started him on an injection regimen, gave him other stuff. Took about 6 months to get him to the right doctor from one doctor to another to a dermatologist because they thought something else but he said no you've got Rheumatoid arthritis and got him to a Rheumatologist. The outcome of the event was unknown.  Information on the lot/batch number has been requested.