This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP) from medical information team for a Pfizer sponsored program. The reporter is the patient. A 55 year-old male patient received bnt162b2 (BNT162B2), administration date 19Mar2021 (Lot number: EN6207) at the age of 54 years as dose 1, single for Covid-19 immunisation. Relevant medical history included: "ulcerative colitis" (unspecified if ongoing). Concomitant medication(s) included: HUMIRA taken for colitis ulcerative. The following information was reported: IMMUNE SYSTEM DISORDER (non-serious) with onset 2021, outcome "unknown", described as "reports he has immune issue". Additional information: Humira last shot on 15Jul2021,The Patient received Dose 2 on 08Apr2021, Lot Number ER8734. Caller was transferred to her by (Withheld) at COVAX Support; CEP (#). Agent states caller wants information on the third booster shot and possibly getting into clinical trials for that, Maybe what that looks like? Agent states that the patient is immunocompromised, and that is the reason he wants information for that. Caller states that bottom line is he thinks there might be something that Pfizer can garner from him. He states that he is on a two-week cycle for Humira for his ulcerative colitis and about the time he took the second dose he had just taken his Humira. He states so maybe it wasn't in his system, maybe it was he doesn't know. He states he took it a day before he thinks. It was just around that time. He states that he did not have any reactions or anything like that, but he states that doesn't necessarily mean that if you have a reaction that it builds up your immune system or not. He states that his thinking is there should have been some sort of direction to make sure you get your vaccine at the end of your cycle or in the beginning of your cycle or something like that. He states that would have been smart. He states there is nothing about immunocompromised people or people who are taking immunosuppressants, so leading up to the approval he has been watching the news and thinking to himself he should think logical about this, he took his last shot of Humira on the 15Jul2021 it has been almost for weeks and the reason why he did that is because he wants it out of his system before he takes the booster shot and he knew they were on the verge of approving the booster shot and everything he read stated it was going to be available right away. He states he doesn't know if he trusts that or not. He states that we are waiting now on the CDC to give their thumbs up, and the FDA just gave their thumbs up, and he was thinking, he wonders if someone wants to track him after he gets his booster shot to see if he had a positive response or not or whatever, whatever he can do to help. He states that he would really like to, he is a single dad basically, and he would rather not die of COVID-19. He states that an advantage for him or reassurance would be for him to get the booster as soon as possible. He states he would like to help but he would not like to wait for the booster shot. He states that he is going to call them right now because from what he read, and he understand they are going to open the flood gates for individuals who are immunocompromised to get a third dose pretty soon here. He states he will give them a call and see if they want him to come by and give some quick blood or whatever they want to do before or after he thought at least that might be a data point for their records. The caller clarifies he had Ulcerative colitis for a long time, prior to the Covid-19 vaccine use. He explains that he is calling because he thinks there is an opportunity to see if he covered and to see how immunocompromise individual respond to the vaccine. He notes he was talking to his pharmacist who has had a kidney transplant and mentioned he took his immune suppressant medication around the time when he got his vaccination. Caller has no information regarding this person and declines to do a report on the pharmacist explaining that is their personal business to report. The caller also states that there are several individuals out there who have this issue and had they been thoughtful about this, regarding taking something to suppress the immune system, they could have planned better. Logic suggest that a person wouldn't want to take something that would suppress the immune response when taking a vaccine. There will have to be better planning next time, for the 3rd shot. No follow-up attempts are possible. No further information is expected.