2 or 3 days into it she had "like Pangea" referring to the injection site, it was very hot, fading as well.; dizziness; fever; body aches; headaches; vomiting; fatigue; joint pain; chills; rash; Patient started to experience symptoms the same night of vaccination , her heart was pounding, she related it to high blood pressure; cold symptoms; the cold symptoms are better, she has body aches, her voice changed, like a really bad cold, she has sore throat,; the cold symptoms are better, she has body aches, her voice changed, like a really bad cold, she has sore throat; was feeling confused; irritability; sleepiness; loss of appetite; This spontaneous case was reported by a patient and describes the occurrence of HYPERTENSION (Patient started to experience symptoms the same night of vaccination , her heart was pounding, she related it to high blood pressure), NASOPHARYNGITIS (cold symptoms), DYSPHONIA (the cold symptoms are better, she has body aches, her voice changed, like a really bad cold, she has sore throat,), OROPHARYNGEAL PAIN (the cold symptoms are better, she has body aches, her voice changed, like a really bad cold, she has sore throat) and CONFUSIONAL STATE (was feeling confused) in a 40-year-old female patient who received mRNA-1273 BIVALENT .222 (MODERNA COVID-19 VACCINE, BIVALENT (ORIGINAL AND OMICRON BA.4/BA.5)) (batch no. 023H22A) for COVID-19 prophylaxis. The occurrence of additional non-serious events is detailed below.     Previously administered products included for Product used for unknown indication: PFIZER BIONTECH COVID-19 VACCINE (Dose 1, lot ep6955) on 29-Mar-2021, PFIZER BIONTECH COVID-19 VACCINE (Dose 2, lot 8931) on 19-Apr-2021, PFIZER BIONTECH COVID-19 VACCINE (Dose 3 and lot SD0809) on 09-Sep-2021. Past adverse reactions to the above products included No adverse event with PFIZER BIONTECH COVID-19 VACCINE, PFIZER BIONTECH COVID-19 VACCINE and PFIZER BIONTECH COVID-19 VACCINE. Concurrent medical conditions included Multiple sclerosis.    On 25-May-2023, the patient received fourth dose of mRNA-1273 BIVALENT .222 (MODERNA COVID-19 VACCINE, BIVALENT (ORIGINAL AND OMICRON BA.4/BA.5)) (unknown route) 1 dosage form. On 25-May-2023, the patient experienced HYPERTENSION (Patient started to experience symptoms the same night of vaccination , her heart was pounding, she related it to high blood pressure), NASOPHARYNGITIS (cold symptoms), DYSPHONIA (the cold symptoms are better, she has body aches, her voice changed, like a really bad cold, she has sore throat,), OROPHARYNGEAL PAIN (the cold symptoms are better, she has body aches, her voice changed, like a really bad cold, she has sore throat), CONFUSIONAL STATE (was feeling confused), IRRITABILITY (irritability), SOMNOLENCE (sleepiness), DECREASED APPETITE (loss of appetite), DIZZINESS (dizziness), PYREXIA (fever), MYALGIA (body aches), HEADACHE (headaches), VOMITING (vomiting), FATIGUE (fatigue), ARTHRALGIA (joint pain), CHILLS (chills) and RASH (rash). On an unknown date, the patient experienced VACCINATION SITE WARMTH (2 or 3 days into it she had "like Pangea" referring to the injection site, it was very hot, fading as well.). The patient was treated with IBUPROFEN (MOTRIN [IBUPROFEN]) for General body pain and Headache, at an unspecified dose and frequency; PARACETAMOL (TYLENOL) for Fever, at an unspecified dose and frequency and DIPHENHYDRAMINE HYDROCHLORIDE (BENADRYL [DIPHENHYDRAMINE HYDROCHLORIDE]) at an unspecified dose and frequency. At the time of the report, HYPERTENSION (Patient started to experience symptoms the same night of vaccination , her heart was pounding, she related it to high blood pressure), NASOPHARYNGITIS (cold symptoms), DYSPHONIA (the cold symptoms are better, she has body aches, her voice changed, like a really bad cold, she has sore throat,), OROPHARYNGEAL PAIN (the cold symptoms are better, she has body aches, her voice changed, like a really bad cold, she has sore throat), CONFUSIONAL STATE (was feeling confused), IRRITABILITY (irritability), SOMNOLENCE (sleepiness), DECREASED APPETITE (loss of appetite), DIZZINESS (dizziness), PYREXIA (fever), MYALGIA (body aches), HEADACHE (headaches), VOMITING (vomiting), FATIGUE (fatigue), ARTHRALGIA (joint pain), CHILLS (chills) and RASH (rash) had not resolved and VACCINATION SITE WARMTH (2 or 3 days into it she had "like Pangea" referring to the injection site, it was very hot, fading as well.) outcome was unknown.        For mRNA-1273 BIVALENT .222 (MODERNA COVID-19 VACCINE, BIVALENT (ORIGINAL AND OMICRON BA.4/BA.5)) (Unknown), the reporter did not provide any causality assessments.   No concomitant medication details was reported.   Reporter did not allow further contact