This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP) from medical information team. The reporter is the patient. A 66 year-old male patient received bnt162b2 (BNT162B2), administration date 24Sep2021 (Lot number: FC3184) at the age of 66 years as dose 3 (booster), single for Covid-19 immunisation. The patient's relevant medical history was not reported. There were no concomitant medications. Past drug history included: Vancomycin, reaction(s): "Drug allergy", notes: He is allergic to vancomycin, but he doesn't have the NDC/lot/expiration. That was 12 years ago. Vaccination history included: Bnt162b2 (His second vaccine was on 3Feb2021, with lot number either EN5318, or EN3318, At the same location as the first vaccine), administration date: 03Feb2021, when the patient was 65 years old, for Covid-19 Immunization; Bnt162b2 (His first dose was Pfizer with lot number EL1283, and he got it on 13Jan2021 at the (withheld)), administration date: 13Jan2021, when the patient was 65 years old, for Covid-19 immunization. The following information was reported: MULTIPLE SCLEROSIS (medically significant), outcome "unknown", described as "The patient might be diagnosed with Multiple Sclerosis at age 66"; VISUAL IMPAIRMENT (non-serious) with onset Oct2021, outcome "not recovered", described as "decline in vision"; DYSCHROMATOPSIA (non-serious), outcome "unknown", described as "decrease in color vision". The events "the patient might be diagnosed with multiple sclerosis at age 66", "decline in vision" and "decrease in color vision" were evaluated at the physician office visit. The patient underwent the following laboratory tests and procedures: magnetic resonance imaging: he had an MRI of his eye which showed no optic neuritis, notes: He had an MRI of his eye which showed no optic neuritis. The doctor said it is probably Multiple Sclerosis causing the vision problems now; magnetic resonance imaging head: white spots on the brain, notes: His MRI shows white spots on the brain. Usually a diagnosis with white spots on the brain is Multiple Sclerosis. He is having a spinal tap to verify that within the next few weeks. Clinical Information: Patient developed a side effect after the COVID booster. His third shot was in Sep2021. He has had perfect vision, and all of the sudden his vision changed drastically. He had an MRI and now there was a possibility he has multiple sclerosis out of no where. The neurologist said he had another patient with the same thing after the COVID booster shot. The patient might be diagnosed with Multiple Sclerosis at age 66. Usually people were diagnosed with Multiple Sclerosis between 20-40 years old. He was 66 years old, and has never had an issue. There was still further testing going on with him. He has been going through testing since Oct2021. He decided to get the vaccine because his son died of COVID at 34 years old. His son was not eligible to get the vaccine at the time he got COVID. It would be a year in two weeks since he died. Patients son got COVID Christmas eve 2020, and his son passed in Apr2021. The vaccine was only for high risk people at that time. With the data he read, and being 65 years old at the time, he decided to do the logical thing and get the COVID vaccine. He knows all of this was new. He was a healthy individual before the COVID booster, and then he got it and his color vision went completely off. He does not have vision far away any more, but he used to be able to see a tick on a horse from 100 yards away. A couple of weeks after the COVID booster was when his vision went down. He got the vaccine in the Sep2021. His weight was 155-157lbs. He got the first two Pfizer COVID vaccines at the county health department. He was unsure if he has permission to give out his doctor's information at this time. He has also seen a retina specialist eye doctor. That doctor agreed it also could have been the COVID booster that caused this. It was occurring in his right eye. It worsened at first, but has seemed to stabilize at this point. He lost color significantly. His color receptors in his right eye gave him the most issue. When his left eye is closed, everything looks pale. If he closes the other eye everything looks sunburnt / red like a lobster. The doctors have been trying to figure out what was going on with the right eye. His MRI shows white spots on the brain. Usually a diagnosis with white spots on the brain was Multiple Sclerosis. He was having a spinal tap to verify that within the next few weeks. He had an MRI of his eye which showed no optic neuritis. The doctor said it was probably Multiple Sclerosis causing the vision problems now. He started visiting the eye doctor when he first noticed the problem with his eye. She told him he needed to go to a Neurologist immediately. His previous eye exam was fine. None of this was there. All of the sudden everything has changed. His first dose was Pfizer with lot number EL1283, and he got it on 13Jan2021 at the Department of Health. His second vaccine was on 03Feb2021, with lot number either EN5318, or EN3318, At the same location as the first vaccine. His booster shot had lot number FC3184, Pfizer, and was given on 24Sep2021. He has had no shingles, no vaccines, or flu shot in probably 14 years. He had not started anything new of any kind. He was allergic to vancomycin, but he does not have the NDC/lot/expiration. That was 12 years ago. He was looking for more information. He saw in an article that a 4th shot/ 2nd booster was about to be available soon. He knows it would be for 65 or older. He was concerned. Should he get the shot or not because of what happened with the first booster. He does not remember, the arm that was used for his first two shots was the left arm because they were drive thru. Time of Onset (24 hour clock): a couple of weeks later something he realized something was off. He does not know exactly when. There was a Big gap between his eye doctor and neurologist appointment because at the time there was a four month wait that luckily he got down to 2 months. His original neurology appointment was not until Mar2022, but he got in in Nov2021. Patient did not required emergency room and required physician office. Did not had prior Vaccinations (within 4 weeks). Patient's Medical History and Relevant Tests was no. Follow-up attempts are completed. No further information is expected. Sender's Comments: Linked Report(s): US-PFIZER INC-202200500573 Same product and event, different patient.