lump of inflammation under skin on low back; rectal bleeding; This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP). The reporter is the patient.  A 28-year-old female patient received BNT162b2 (BNT162B2), on 15May2021 as dose 2, single (Lot number: EV0179) intramuscular, in right arm for covid-19 immunisation. The patient's relevant medical history included: "Endometriosis", start date: Mar2020 (ongoing); "anxiety" (unspecified if ongoing); "Sleep" (unspecified if ongoing). Concomitant medication(s) included: NORETHINDRONE [NORETHISTERONE] oral taken for endometriosis, start date: Feb2022 (ongoing); LETROZOLE oral taken for endometriosis, start date: Feb2022 (ongoing); NALTREXONE oral taken for pain, start date: Feb2022 (ongoing); HYDROXYZINE taken for sleep disorder, anxiety (ongoing). Vaccination history included: BNT162b2 (Dose 1, Anatomical Site of injection: Right arm, Route of administration: Intramuscular, Batch/Lot number: EP7533), administration date: 09Apr2021, for Covid-19 immunization. The following information was reported: RECTAL HAEMORRHAGE (medically significant) with onset Jan2022, outcome "unknown", described as "rectal bleeding"; MASS (non-serious) with onset Feb2022, outcome "not recovered", described as "lump of inflammation under skin on low back". The events "rectal bleeding" and "lump of inflammation under skin on low back" required physician office visit. Clinical course: Patient reported: "I received surgery ER endometriosis 10Aug2021, on 23Aug2021, my mom passes away in my apt due to Covid + cirrhosis of the liver. I had to move her, which I shouldn't have been pulling during that time after surgery. I was diagnosed with Covid that and was in debilitating pain until starting low dose naltrexone WI wholistic doctor. In January (Jan2022), I had rectal bleeding so bad I had to wear a diaper. The lump on my back (also reported as "Lump of inflammation under skin on low back-unknown cause") showed up, disappeared with super laxative before colonoscopy and has been there since the following day. I got the X-ray, Ultrasound plus MRI done with no findings (also reported as "Nothing shows on X-ray, Ultrasound or MRI low back, shows on MRI pelvis"). Then, I got my Booster. I was in terrible pain for a week and then bruising on my pelvic floor has appeared. Both the lump plus bruising change in size and appearance. No doctor has been able to help or known what this is. I also have a bad muscle spasms in right quad. I moved back home so my doctor couldn't fill this out and is no longer at (facility name Withheld)". "Endometriosis Surgery 08Oct2021, laparoscopic excision stage 2" was also reported. The patient underwent the following laboratory tests and procedures: Colonoscopy: (unspecified date) Unknown results; Magnetic resonance imaging: (08Apr2022) Normal; Magnetic resonance imaging abdominal: (unspecified date) Scar tissue or endo; (06May2022) inflammation under skin; Spinal X-ray: (03Mar2022) Normal; (06May2022) Normal; Ultrasound scan: (19Mar2022) Normal. Sender's Comments: Linked Report(s): US-PFIZER INC-202201375163 same patient and suspect vaccine; different dose and events;US-PFIZER INC-PV202300020697 same patient and suspect vaccine; different dose and events;