This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP). The reporter is the patient. A 53-year-old female patient (not pregnant) received BNT162b2 (BNT162B2), on 15Apr2021 at 15:00 as dose 2, single (Lot number: ER8732) at the age of 53 years, in left arm for covid-19 immunisation. The patient had no relevant medical history. The patient's concomitant medications were not reported. Vaccination history included: BNT162b2 (Dose Number: 1, Batch/Lot No: EW0161, Location of injection: Arm Left, Vaccine Administration Time: 12:00 PM), administration date: 18Mar2021, when the patient was 53-year-old, for COVID-19 immunization, reaction(s): "Fluid removed each symptom Started about 1 month after each dose". The following information was reported: LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (non-serious) with onset 06May2021, outcome "not recovered", described as "I don't do activities that require me walking a long time"; INFLAMMATION (non-serious) with onset 06May2021, outcome "not recovered", described as "I have extremely high Inflammation in blood work"; PAIN IN EXTREMITY (non-serious) with onset 06May2021, outcome "not recovered", described as "Im missing out on life from pain on my feet and fingertips"; ONYCHALGIA (non-serious), BURNING SENSATION (non-serious) all with onset 06May2021, outcome "not recovered" and all described as "Pain/burning Nails"; NAIL DISORDER (non-serious) with onset 06May2021, outcome "not recovered", described as "Pain/burning Nails are paper thin with ridges"; ERYTHEMA (non-serious) with onset 06May2021, outcome "not recovered", described as "Red toes and fingertips"; RAYNAUD'S PHENOMENON (non-serious) with onset 06May2021, outcome "not recovered", described as "Red toes and fingertips. Pain/burning Nails are paper thin with ridges Very itching I have had fluid /bump on my elbow"; PRURITUS (non-serious) with onset 06May2021, outcome "not recovered", described as "Very itching"; JOINT EFFUSION (non-serious) with onset 06May2021, outcome "not recovered", described as "fluid /bump on her elbow and her toe". The events "fluid /bump on her elbow and her toe", "red toes and fingertips", "pain/burning nails", "pain/burning nails are paper thin with ridges", "very itching", "i don't do activities that require me walking a long time", "im missing out on life from pain on my feet and fingertips", "red toes and fingertips. pain/burning nails are paper thin with ridges very itching i have had fluid /bump on my elbow" and "i have extremely high inflammation in blood work" required physician office visit. Relevant laboratory tests and procedures are available in the appropriate section. Therapeutic measures were taken as a result of joint effusion, erythema, onychalgia, burning sensation, nail disorder, pruritus, loss of personal independence in daily activities, pain in extremity, raynaud's phenomenon, inflammation. Additional Information: The patient not received other vaccine in four weeks. Red toes and fingertips. Pain/burning Nails are paper thin with ridges Very itching I have had fluid /bump on my elbow and my toe as well. Fluid removed each symptom Started about 1 month after each dose. Tested negative for Lyme, diabetes had X-rays taken nothing found. I have extremely high Inflammation in blood work and my feet has caused me to miss work. I don't do activities that require me walking a long time. I've seen my MD 8 times in a year syndrome but it's not I'm missing out on life from pain on my feet and fingertips I have had 4 total Covid vaccines. Apr, Mar, Nov2021 and Apr2022. Ae treatment: Cortisone cream steroid cream. No known allergies. No follow-up attempts are possible. No further information is expected.