This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP). The reporter is the patient. A 70-year-old male patient received BNT162b2 (BNT162B2), on 25Apr2022 at 11:00 as dose 4 (booster), single (Lot number: FM9992) at the age of 70 years, in arm for covid-19 immunisation. The patient's relevant medical history included: "Underactive thyroid" (unspecified if ongoing); "Vitamin D decreased" (unspecified if ongoing); "small kidney stone" (unspecified if ongoing), notes: happened well before the vaccine; "childhood illnesses" (unspecified if ongoing), notes: Had childhood illnesses; "flu" (unspecified if ongoing), notes: Had childhood illnesses and a bad bout of flu 20 years ago; "seasonal allergies" (unspecified if ongoing). Concomitant medication(s) included: LEVOTHYROXINE taken for hypothyroidism; BABY ASPIRIN; VITAMIN D NOS taken for vitamin d decreased; CHLORPHENAMINE MALEATE;PHENYLEPHRINE HYDROCHLORIDE taken for seasonal allergy; ACETAMINOPHEN. Vaccination history included: BNT162b2 (DOSE 1, SINGLE; Lot No: EL1283; Location: Left arm; Time: around 8:30-10:00 am), administration date: 19Jan2021, when the patient was 68-year-old, for COVID-19 immunisation; BNT162b2 (DOSE 2, SINGLE; Lot No: EM9810; Location: Right arm; Time: around 8:30-10:00 am), administration date: 09Feb2021, when the patient was 68-year-old, for covid-19 immunisation; BNT162b2 (DOSE 3 (BOOSTER), SINGLE; Lot No: FF2500 or FF2508; Location: Right arm; Time: around 10:30-11:00 am), administration date: 26Sep2021, when the patient was 69-year-old, for Covid-19 immunisation; Hepatitis vaccine, for Immunization. The following information was reported: ELECTROPHORESIS PROTEIN ABNORMAL (non-serious) with onset 27Apr2022, outcome "unknown", described as "proteins in his blood showing abnormal protein bands"; MONOCLONAL GAMMOPATHY (non-serious) with onset 27Apr2022, outcome "unknown", described as "some concern about whether that is monoclonal gammopathy or something more serious". The events "proteins in his blood showing abnormal protein bands" and "some concern about whether that is monoclonal gammopathy or something more serious" required physician office visit. Relevant laboratory tests and procedures are available in the appropriate section. Additional information: Patient reported that he was very good health and only medication he takes is for an underactive thyroid. Has had very good physical reports for last over 5 years or more. His past physical he got a report that proteins in his blood showing abnormal protein bands and there is some concern about whether that is monoclonal gammopathy or something more serious. The only thing different for his health in the past year and a half is he has taken 4 Pfizer vaccines. He knows mRNA vaccines interact with proteins in blood so asked is there any connection between the vaccine and abnormal protein bands in the blood, So far everyone says this is not a concern as it hasn't been reported. Only thing different is he has taken mRNA vaccine and would like scientific explanation if it's not related why that is and if there are any other reports of this happening. He was quite surprised as he is in great health and now has had a consultation with hematologist with cancer center. If there is an issue, people are saying no but by same token they don't know the cause of why protein bands are forming, saying there is no origin or cause and are quick to say it's not from the vaccine. Has had other issues with vaccines in the past and wants to rule out anything. He would say his physicals for the last 15 years have been good. On 27Apr2022 he had Protein Total and Protein Electrophoresis, Immunofixation serum interpretation and a basic urinalysis done. On 01Aug2022 the hematologist did a full spectrum bloodwork and the results are unknown. Protein bands detected in this also so it's not an anomaly. Has been tested in 2 places and different times and they are still showing up. Concerned with 1st Pfizer Covid booster as it seemed lax procedure and he didn't know if it was the correct temperature. 1st booster Pfizer Covid vaccine on 26Sep2021. Lot FF2500 or FF2508 in his right arm around 10:30-11am. They put it in very high on his arm. It's usually just a little below shoulder but this was high up, closer to the shoulder, higher than others. His physical was bloodwork on 13Apr2022 and saw the doctor on 27Apr2022 who said on the 27th that overall protein total was in range with indication of high protein level and took blood work on 27Apr2022 and did again at the hematologist on 01Aug2022. Has had 2 consults with hematologist who says his condition is unknown origin and cause and there is no treatment for it. They don't know what is causing the protein bands to form and they will have to monitor as it can develop to myeloma. This may be nothing but if it affects other people he thinks it needs to be known. He got a preliminary report 2 days ago that they detected similar protein bands and was not enormously high but higher than should be. Has been told this situation usually happens in men more than women around age 70 and he just turned 70 and is male and may just be a coincidence. Would really like to know, they can't tell him, gave him a preliminary MGUS (Monoclonal gammopathy of undetermined significance) diagnosis but don't know cause or treatment for it. Would like scientific information saying it's impossible for the vaccine to have caused this. The only thing is he took that vaccine that interacts and now having abnormal blood protein. In his mind that seemed odd to him. Proteins showing in test different than what the vaccine interacts with he would like some knowledge as to this is the reason why interact. He is hoping this is an anomaly but the way tests are looking it is not real encouraging, he hopes to get answers if it's related to the vaccine Pfizer should know it's a possibility. Concomitant medications: Levothyroxine started taking around 2010-2012. baby aspirin took 1 every day between 2010-2018 and about 4-5 years ago started taking it 2-3 times a week. Vitamin d around 2008-2009 his vitamin D level dropped and took to boost his level and now acceptable range low acceptable range but in range. Multivitamin takes a couple times a week when he remembers. started about 20-25 years ago. Chlorpheniramine Maleate 2mg and phenylephrine HCL 5mg allergy medication for seasonal allergies. Takes 1 a day and not every day just as needed sometimes he might separate the tablets, sometimes takes with acetaminophen 325mg, takes 1 but won't take more than 2 a day, can take up to 2 tablets every 4 hours. Has tried different brands and generic but tends to go back to this one. Prior Vaccinations (within 4 weeks): None.