100 degree fever; chills; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP). The reporter is the patient. Other Case identifier(s): LRN4362815.  A 33-year-old female patient received BNT162b2 (BNT162B2), on 26Mar2021 as dose 1, single (Batch/Lot number: unknown) at the age of 32 years for covid-19 immunisation. The patient's relevant medical history included: "Ulcerative colitis" (unspecified if ongoing); "Ovarian Cysts" (unspecified if ongoing); "Shingles" (unspecified if ongoing); "Wheelchair Bound" (unspecified if ongoing); "Cut her wrists in high school" (unspecified if ongoing); "High Blood Pressure" (unspecified if ongoing); "Right hand swelling" (unspecified if ongoing), notes: Right hand swelling; unable to write; "Multiple sclerosis" (unspecified if ongoing); "Asthma" (unspecified if ongoing); "Cat Dander Allergy" (unspecified if ongoing); "Mango allergy" (unspecified if ongoing); "Artificial Sweetener Allergy" (unspecified if ongoing); "Panic Attacks" (unspecified if ongoing); "Costochondritis" (unspecified if ongoing); "Depression" (unspecified if ongoing); "Leg Spasms" (unspecified if ongoing); "Multiple Sclerosis Pain" (unspecified if ongoing); "Anxiety" (unspecified if ongoing); "Heart Burn" (unspecified if ongoing); "Vertigo" (unspecified if ongoing); "Nausea" (unspecified if ongoing); "Lack of appetite" (unspecified if ongoing); "Migraines" (unspecified if ongoing); "Loss of dexterity in right hand" (unspecified if ongoing); "Right hand weakness" (unspecified if ongoing); "Right hand and wrist nerve issues" (unspecified if ongoing), notes: Right hand and wrist nerve issues; "PML" (unspecified if ongoing), notes: Positive for PML; "Walker use" (unspecified if ongoing); "Use of a cane" (unspecified if ongoing); "Macrobid Allergy" (unspecified if ongoing); "Right hand swelling; unable to write" (unspecified if ongoing), notes: Right hand swelling; unable to write. Concomitant medication(s) included: ALLEGRA [FEXOFENADINE HYDROCHLORIDE]; FLOVENT; FLONASE [FLUTICASONE PROPIONATE]; CELECOXIB; PANTOPRAZOLE; LYRICA; MECLIZINE [MECLOZINE]; TIZANIDINE; ESCITALOPRAM; PROCHLORPERAZINE; SUMATRIPTAN. Past drug history included: Tysabri, reaction(s): "Multiple Sclerosis Flare-up", notes: Multiple Sclerosis Flare-up-when switching from Copaxone to Tysabri; Golytely, reaction(s): "Allergy". The following information was reported: PYREXIA (non-serious) with onset 26Mar2021, outcome "unknown", described as "100 degree fever"; CHILLS (non-serious) with onset 26Mar2021, outcome "unknown". Relevant laboratory tests and procedures are available in the appropriate section.  Additional information: Patients past medical history included: Ulcerative colitis, Ovarian Cysts, Shingles, Wheelchair Bound, Cut her wrists in high school, Multiple Sclerosis Flare-up-when switching from Copaxone to Tysabri, High Blood Pressure, Use of a wheelchair, Walker use, Use of a cane, Right hand swelling; unable to write, Positive for PML. Patients concurrent condition included: Multiple sclerosis, Asthma, Cat Dander Allergy, Mango, Allergy, Artificial Sweetener Allergy, Macrobid Allergy, Golytely Allergy, Panic Attacks, Costochondritis, Depression, Leg Spasms, Multiple Sclerosis Pain, Anxiety, Heart Burn, Vertigo, Nausea, Lack of appetite, Migraines, Loss of dexterity in right hand,Right hand weakness, Right hand and wrist nerve issues. On 26Mar2021, patient started therapy with Pfizer Covid Vaccine for unknown indication. On 26Mar2021, 23Sep2022, it was reported that patient experienced: patient reported beginning 23Sep2022, she experienced a headache after receiving her Covid-19 Booster shot, The headache was further clarified as I received the booster around 1:15, and the headache started around 7:30pm, patient stated when she received her initial covid vaccine on 26Mar2021 she experienced a 100 degree fever. She also experienced chills throughout the night and that was confirmed to last for 2-3 days following the covid vaccine, patient reported beginning 23Sep2022 she experienced tiredness after receiving the covid booster. The outcome of the reported event(s) was Unknown. We have no further information regarding the reported event(s) described above. Any additional material information received will be forwarded to you in accordance with company's policies and procedures.  The information on the batch/lot number for BNT162b2 has been requested and will be submitted if and when received.