I got the booster; I had significant myalgias; fatigue; some nausea; elevated alkaline phosphatase, bilirubin, and transaminases/they went even higher and now; This is a spontaneous report received from a contactable reporter(s) (Other HCP).  An adult male patient received bnt162b2 (BNT162B2), administration date 01Oct2021 (Batch/Lot number: unknown) as dose 3 (booster), single for covid-19 immunisation. The patient's relevant medical history and concomitant medications were not reported. Vaccination history included: Bnt162b2 (Previous dose details, Dose product: Covid-19, Dose brand: Pfizer, dose brand unknown: False, dose lot number: NA, dose lot unknown: False, dose number: 2), for Covid-19 immunisation, reaction(s): "Pfizer COVID vaccine causing elevated alkaline phosphatase, bilirubin, and transaminases Mine were incidentally found to be elevated", "Pfizer COVID vaccine causing elevated alkaline phosphatase, bilirubin, and transaminases Mine were incidentally found to be elevated", "Pfizer COVID vaccine causing elevated alkaline phosphatase, bilirubin, and transaminases Mine were incidentally found to be elevated"; Bnt162b2 (Dose product: Covid-19, Dose brand: Pfizer, dose brand unknown: False, dose lot number: NA, dose lot unknown: False, dose number: 1), for Covid-19 immunization, reaction(s): "Pfizer COVID vaccine causing elevated alkaline phosphatase, bilirubin, and transaminases Mine were incidentally found to be elevated"; Bnt162b2 (Dose product: Covid-19, Dose brand: Pfizer, dose brand unknown: False, dose lot number: NA, dose lot unknown: False, dose number: 1), for Covid-19 immunization, reaction(s): "Pfizer COVID vaccine causing elevated alkaline phosphatase, bilirubin, and transaminases Mine were incidentally found to be elevated"; Bnt162b2 (Dose product: Covid-19, Dose brand: Pfizer, dose brand unknown: False, dose lot number: NA, dose lot unknown: False, dose number: 1), for Covid-19 immunization, reaction(s): "Pfizer COVID vaccine causing elevated alkaline phosphatase, bilirubin, and transaminases Mine were incidentally found to be elevated". The following information was reported: IMMUNISATION (non-serious) with onset 01Oct2021, outcome "unknown", described as "I got the booster"; MYALGIA (non-serious) with onset 01Oct2021, outcome "not recovered", described as "I had significant myalgias"; FATIGUE (non-serious) with onset 01Oct2021, outcome "not recovered", described as "fatigue"; NAUSEA (non-serious) with onset 01Oct2021, outcome "not recovered", described as "some nausea"; CONDITION AGGRAVATED (non-serious) with onset 01Oct2021, outcome "not recovered", described as "elevated alkaline phosphatase, bilirubin, and transaminases/they went even higher and now". The events "i had significant myalgias", "fatigue", "some nausea" and " elevated alkaline phosphatase, bilirubin, and transaminases/they went even higher and now" were evaluated at the physician office visit. Relevant laboratory tests and procedures are available in the appropriate section. It was unknown if therapeutic measures were taken as a result of myalgia, fatigue, nausea. Therapeutic measures were not taken as a result of condition aggravated.  Additional information: Have you heard anything about the Pfizer COVID vaccine causing elevated alkaline phosphate, bilirubin, and transaminases? Mine were incidentally found to be elevated 5 mo after my initial series, then trended down until August. It was reported that the patient received his booster dose 01Oct2021 (after which he had significant myalgias, fatigue, and some nausea) and they went even higher and now aren't coming down. All other causes/etiologist have been ruled out with a complete workup. Next step is liver biopsy which is on Monday. I submitted a VAERS report. Unknown if patient received other vaccine in four weeks; It was Unknown if patient had COVID prior vaccination, If COVID tested post vaccination and any known allergies. Unknown if patient received any treatment AE.  The lot number for bnt162b2 was not provided and will be requested during follow up.; Sender's Comments: Linked Report(s) : US-PFIZER INC-202101587478 similar report from same reporter