friends parents took the COVID vaccine and passed away; This is a spontaneous report received from a non-contactable reporter(s) (Consumer or other non-HCP) from medical information team.  A female patient received BNT162b2 (BNT162B2), as dose number unknown, single (Batch/Lot number: unknown) for covid-19 immunisation. The patient's relevant medical history and concomitant medications were not reported.  The following information was reported: DEATH (death, medically significant), outcome "fatal", described as "friends parents took the COVID vaccine and passed away". The date and cause of death for the patient were unknown. It was not reported if an autopsy was performed.  Clinical course: Question: Call received from. Caller has not had the COVID vaccine and is concerned. Caller wants to know how does the vaccine works with new variants of COVID. She wants to understand the biochemistry. Caller compares it to the flu vaccine and how the influenza virus changes yearly. Caller states COVID is on the 7th mutation & Pfizer created a vaccine that was for the 1st variant. Caller notes that Omicron has 47 different mutations and how one would make a vaccine that is effective against the other variants. Caller stated that there are no vaccines that they are aware of that can do this but yet Pfizer claims that the vaccine does. Caller states that unless they created this robotic vaccine, there is no way. Caller states that they are in the medical field, and they do not feel as though it makes sense how the biochemistry works for the product. Caller states that her father does not feel as though it makes any sense and thus, they have not received the vaccine at this time. Caller questions the biochemistry of the product and wants to know if they are taking the mRNA from the crown. Caller states the only thing that does change is the crown and wants to know if this is where it is coming from. Caller notes that the news is stating that the product is only 10% effective with the new variant. Caller states that is bearly making it. Caller states they do not understand how it is working and they are confused and despite their medical background, they do not feel as though it makes sense from a biochemistry standpoint. Caller states they were mad because they followed all the things and they still passed away. Caller wants to know how come Pfizer is not liable for putting a product like this on the market and patients passing away. Caller states she spoke with a lawyer and the lawyer advised them that Pfizer is not liable. Caller wants to know who cannot take the product. Caller wants to know if there is an allergy test that can be done prior to taking the product. Caller spoke with her provider regarding this and they advised to contact either Pfizer or Moderna. Advised the caller that she would have to speak with the HCP regarding testing available for such request, Pfizer MI does not have guidance on said testing or availability of such. Advised that we would be able to provide her with a list of ingredients to then further review with her HCP.  No follow-up attempts are possible; information about lot/batch number cannot be obtained. No further information is expected.; Sender's Comments: Linked Report(s) : US-PFIZER INC-202200651970 Same reporter/vaccine/event, different patient; Reported Cause(s) of Death: friends parents took the COVID vaccine and passed away