Could not walk; could not close right hand; administered in the right arm on 16Oct2021 12:30 (at the age of 47 year old) as dose 3 (booster; major swelling in both knees, right hand fingers, left foot/major pain in all those areas; major swelling in both knees, right hand fingers, left foot/major pain in all those areas; major swelling in both knees, right hand fingers, left foot/major pain in all those areas; major swelling in both knees, right hand fingers, left foot/major pain in all those areas; Booster; The initial safety information received was reporting only non-serious adverse drug reactions. Upon receipt of follow-up information on 10Nov2021, this case now contains serious adverse reactions. Information processed together.  This is a spontaneous report from a contactable consumer (patient). A 47-year-old female patient received BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE, solution for injection, lot number: FE3592), via an unspecified route of administration, administered in the right arm on 16Oct2021 12:30 (at the age of 47 years old) as dose 3 (booster), single for COVID-19 immunization. Medical history included clinical depression from Oct2017 and ongoing and gold and nickel metals from an unknown date and unknown if ongoing. The patient is not pregnant. Concomitant medications included bupropion taken for depression from Oct2017 and ongoing; colecalciferol (VITAMIN D) taken for an unspecified indication, start and stop date were not reported and turmeric supplement. The patient previously received BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE, solution for injection), via an unspecified route of administration, administered in the right arm on 17Mar2021 15:30 (at the age of 46 years old; lot number: EP6955) as dose 1, single for COVID-19 immunization; and BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE, solution for injection), via an unspecified route of administration, administered in the right arm on 14Apr2021 09:30 (at the age of 46 years old; lot number: EW0161) as dose 2, single  for COVID-19 immunization and experienced neck stiffness, joint swelling in left foot, stiffness in knee, pain in knee, neck pain and psoriatic arthritis. The patient experienced major swelling in both knees, right hand fingers, left foot/major pain in all those areas on 17Oct2021 07:00, could not walk, could not close right hand on 18Oct2021 and booster on 16Oct2021 12:30. It was reported that on 17Oct2021, the patient experienced knee swelling, hand swelling, foot swelling, knee pain. The reporter assessed the events knee swelling, hand swelling, foot swelling, knee pain as serious (persistent/significant disability/incapacity, important medical events) and these events required physician office visit. Treatment included prednisone, methotrexate and folic acid. The patient underwent lab tests and procedures which included blood test: elevated inflamatory markers on 21Sep2021 and x-ray: right hand, some swelling on 20Sep2021. The outcome of the events major swelling in both knees, right hand fingers, left foot/major pain in all those areas was not recovered while the outcome of all other events was unknown.  No follow-up attempts are needed. No further information is expected.