Tingling lips; nose and cheeks tingling; Chest tightness; This is a spontaneous report from a contactable consumer (patient). An 82-year-old female patient received bnt162b2 (PFIZER-BIONTECH mRNA COVID-19 VACCINE, solution for injection, Batch/Lot Number: EN6206), dose 1 via an unspecified route of administration, administered in arm right on 28Feb2021 (at the age of 82-year-old) administered at approximately 13:30-13:45 (at the age of 82-year-old) as dose 1, single for COVID-19 immunisation. She did not have prior vaccinations in 4 weeks. Medical history included multiple allergies. she had allergies to Penicillin and Sulfa, since in her 40s. Concomitant medications included (procaine hydrochloride) NOVOCAIN taken for an unspecified indication from 24Feb2021 to an unspecified stop date. She had dental work on Wednesday, 24Feb2021, that included a shot of Novocain. She said she wondered if the Novocain shot had anything to do with the COVID-19 Vaccine causing the tingling in her lips, nose and cheeks, since everything she experienced on 28Feb2021 happened in her face area. She did not have the Novocain dose, NDC, Lot, and Expiration Date. The patient previously took codeine experienced drug allergies. She said her second COVID-19 Vaccine was a couple days before the recommended 21 days between COVID-19 Vaccine doses. The patient experienced tingling lips, nose and cheeks tingling, chest tightness on 28Feb2021 at 22:00. She clarified the tingling in her cheeks was higher up around her cheek bones. She said her cheek tingling was not as strong as the tingling in her lips and nose. She had allergies, and was scared, so she went to the emergency room. She clarified her lips, nose, and cheeks tingling started approximately 5 hours after she received her first COVID-19 Vaccine shot. She said she went to the emergency room about 5 hours after the tingling started, at 22:00 (28Feb2021). Treatment was reported as she was given 1 intramuscular shot of Benadryl while she was in the emergency room. She said she did not know the Benadryl dose or the Benadryl NDC, Lot, and Expiration Date. She clarified the intramuscular Benadryl shot did not effect her lip, nose and cheek tingling at all. She said she was wondering if she should get the second COVID-19 Vaccine shot. She was discharged home from the emergency room after about 2 hours. She said she was given a prescription for oral Benadryl 25mg by mouth, four times a day, as needed, for itching and allergies (30 tablets). She said she did not fill the Benadryl 25mg tablet prescription because she did not think the Benadryl prescription was necessary. she also had felt a little tightening in the center of her upper chest area, towards her throat. She said the chest tightening was very slight, so much so, that she thought the chest tightening maybe her imagination. She said the slight chest tightening went away sooner than her lip, nose, and cheek tingling. The tingling in her lips, nose, and cheeks was much less by the next morning (01Mar2021) and was completely gone by noon (01Mar2021). She said she called her dentist on 01Mar2021 to ask if he thought the Novocain could have contributed to her lips, nose, and cheeks tingling. She said her dentist told her he didn't think the Novocain had anything to do with the tingling she experienced after getting the COVID-19 Vaccine. She said she had Novocain in the past, and Novocain had never caused her to have a reaction. The second COVID-19 Vaccine dose was scheduled for 19Mar2021. The outcome of the event was recovered on 01Mar2021   No follow-up attempts are possible. No further information is expected.