Acute pancreatitis/ Doctors felt that either Hydrochlorothiazide or the Moderna Covid-19 booster could have caused the pancreatitis; severe stomach pain.; very ill after booster dose; loss of appetite; chills; mild fever; This spontaneous case was reported by a consumer and describes the occurrence of PANCREATITIS ACUTE (Acute pancreatitis/ Doctors felt that either Hydrochlorothiazide or the Moderna Covid-19 booster could have caused the pancreatitis) and ABDOMINAL PAIN UPPER (severe stomach pain.) in a 57-year-old male patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch no. 022C21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.    Co-suspect product included non-company product HYDROCHLOROTHIAZIDE for an unknown indication.    Concurrent medical conditions included Asthma chronic. Concomitant products included LORAZEPAM (ATIVAN) for Sleep disorder, METOPROLOL, MONTELUKAST, SERTRALINE and ZOLPIDEM for an unknown indication.   On 19-Sep-2021, the patient received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On an unknown date, the patient started HYDROCHLOROTHIAZIDE (unknown route) at an unspecified dose. On 19-Sep-2021, the patient experienced ILLNESS (very ill after booster dose), DECREASED APPETITE (loss of appetite), CHILLS (chills) and PYREXIA (mild fever). On 02-Oct-2021, the patient experienced ABDOMINAL PAIN UPPER (severe stomach pain.) (seriousness criterion hospitalization). On 03-Oct-2021, the patient experienced PANCREATITIS ACUTE (Acute pancreatitis/ Doctors felt that either Hydrochlorothiazide or the Moderna Covid-19 booster could have caused the pancreatitis) (seriousness criteria hospitalization and medically significant). The patient was hospitalized from 03-Oct-2021 to 14-Oct-2021 due to ABDOMINAL PAIN UPPER and PANCREATITIS ACUTE. At the time of the report, PANCREATITIS ACUTE (Acute pancreatitis/ Doctors felt that either Hydrochlorothiazide or the Moderna Covid-19 booster could have caused the pancreatitis), ABDOMINAL PAIN UPPER (severe stomach pain.), ILLNESS (very ill after booster dose), DECREASED APPETITE (loss of appetite), CHILLS (chills) and PYREXIA (mild fever) outcome was unknown.        For mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular), the reporter considered PANCREATITIS ACUTE (Acute pancreatitis/ Doctors felt that either Hydrochlorothiazide or the Moderna Covid-19 booster could have caused the pancreatitis) to be related. No further causality assessments were provided for ABDOMINAL PAIN UPPER (severe stomach pain.), ILLNESS (very ill after booster dose), DECREASED APPETITE (loss of appetite), CHILLS (chills) and PYREXIA (mild fever).    Patient received the booster dose in right arm shoulder deltoid muscle.  The patient went to the hospital on 03-Oct-2021 and was diagnosed with acute pancreatitis.  No treatment information was provided.  For hydrochlorothiazide, the reporter considered PANCREATITIS ACUTE (Acute pancreatitis/ Doctors felt that either Hydrochlorothiazide or the Moderna Covid-19 booster could have caused the pancreatitis) to be related.  Company comment: This case concerns a 57-year-old male patient, with medical history of asthma, who experienced the serious unexpected events Pancreatitis Acute (AESI) and abdominal pain upper after the third dose of mRNA-1273. The events occurred 14 days after as reported booster dose of mRNA-1273, the patient was hospitalized and discharged 11 days later. No further information provided. It was reported that the doctors felt that either Hydrochlorothiazide or the Moderna Covid-19 booster could have caused the pancreatitis. The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report.   This case was linked to MOD-2022-455495, MOD-2022-455481.; Sender's Comments: This case concerns a 57-year-old male patient, with medical history of asthma, who experienced the serious unexpected events Pancreatitis Acute (AESI) and abdominal pain upper after the third dose of mRNA-1273. The events occurred 14 days after as reported booster dose of mRNA-1273, the patient was hospitalized and discharged 11 days later. No further information provided. It was reported that the doctors felt that either Hydrochlorothiazide or the Moderna Covid-19 booster could have caused the pancreatitis. The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report.