Felt sluggish due to COVID 19 vaccine; worsened right knee, right hip and right shoulder pain; This is a spontaneous report from contactable Consumer or other non-HCP (patient), based on the information received by Pfizer from AbbVie Inc. (MFR Control No. # 21K-163-4098386-00).  A 60-year-old male patient received BNT162B2 (PFIZER-BIONTECH COVID-19 mRNA VACCINE (TOZINAMERAN), Solution for injection, Batch/Lot number: Unknown), via intramuscular route of administration on 02Mar2021 (at the age of 60 year-old), as DOSE 1, SINGLE for COVID-19 immunization (reported term COVID-19 Vaccination) and Upadacitinib (RINVOQ, Tablet, Batch/Lot number: Unknown), via oral route of administration from an unspecified date in Feb2021 and still ongoing, at 15 mg for rheumatoid arthritis. Patient medical history included thyroid issues, type 1 diabetes mellitus, rheumatoid arthritis pain, high blood pressure, cholesterol, he had two knee surgeries (Right knee surgery), Hernia surgery, The patient was nontobacco user and alcohol use/wine, beer, whiskey occasional drinker. The concomitant medications included Levothyroxine sodium (SYNTHROID) taken for thyroid issues, Insulin aspart (NOVOLOG) taken for type 1 diabetes mellitus, Insulin glargine (BASAGLAR) taken for long-acting insulin therapy, Famotidine, Ibuprofen (DUEXIS) taken for rheumatoid arthritis pain, Hydrochlorothiazide, losartan potassium (LOSARTAN HCTZ) taken for high blood pressure, Fenofibrate (FENOFIBRATE) taken for cholesterol medication, Rosuvastatin taken for cholesterol, Hydrochlorothiazide taken for blood pressure, Acetylsalicylic acid (BABY ASPIRIN) taken for stroke prevention. He had taken unknown daily multivitamins. The patient previously taken Humira, and Methotrexate for Rheumatoid arthritis and he was allergic to avalox manifested as turned into lobster red, Bactrim allergy manifested as lobster red. The patient experienced worsened right knee, right hip and right shoulder pain on an unspecified date in 2021, felt sluggish due to covid 19 vaccine with Rinvoq (Upadacitinib) on 02Mar2021. It was reported that he was not getting pain relief from Rinvoq and his right hip hurt in the morning on an unknown date in 2021. Pfizer Biontech covid-19 vaccine (Tozinameran) was also considered suspect. It was unknown if patient was enrolled in a covid-19 vaccine trial. The duration of the felt sluggish due to COVID 19 vaccine was 2 days. Action(s) taken with RINVOQ was Does not changed with respect to the event Arthralgia aggravated. Action(s) taken with RINVOQ was unknown with respect to the event Sluggishness. The patient received second dose of BNT162B2 (PFIZER-BIONTECH COVID-19 mRNA VACCINE (TOZINAMERAN), Solution for injection, Batch/Lot number: Unknown), via intramuscular route of administration on 23Mar2021 (at the age of 60 years-old) as dose 2, single for COVID-19 immunization. The events were reported as non-serious. The clinical outcome of event worsened right knee, right hip and right shoulder pain was not resolved and felt sluggish due to COVID 19 vaccine was resolved on 04Mar2021.   Causality for HUMIRA(ADALIMUMAB): unknown allergy pill. The reporter alternative etiology for the events of worsened right knee, right hip and right shoulder pain was reported as rheumatoid arthritis. For the event of felt sluggish, the reporter alternative etiology was reported as covid 19 vaccine.  Causality for Rinvoq (Upadacitinib): The reporter's causality for the events of worsened right knee, right hip and right shoulder pain and felt sluggish due to covid 19 vaccine with Rinvoq (Upadacitinib) was no reasonable possibility (Not Related).  Causality for PFIZER BIONTECH COVID-19 VACCINE: The reporter's causality for the events of worsened right knee, right hip and right shoulder pain and felt sluggish due to covid 19 vaccine was not reported.   No follow-up attempts are possible; information about lot/batch number cannot be obtained. No further information is expected.