felt pressure around their heart and tightness around their heart; thoracic discomfort/Chest tightness/discomfort when she bent forward or rotated torso, which was intermittent; atypical substernal chest sharp pain on day 1 then discomfort for about 6 days after that/fleeting stabbing pain in left anterior chest area, very deep/Also noted when she took a very deep inspiration/ Next few days, fleeting but never sharp again; sore upper arm for 2.5 days; This spontaneous case was reported by a physician and describes the occurrence of CHEST DISCOMFORT (felt pressure around their heart and tightness around their heart), CHEST DISCOMFORT (thoracic discomfort/Chest tightness/discomfort when she bent forward or rotated torso, which was intermittent), CHEST PAIN (atypical substernal chest sharp pain on day 1 then discomfort for about 6 days after that/fleeting stabbing pain in left anterior chest area, very deep/Also noted when she took a very deep inspiration/ Next few days, fleeting but never sharp again) and PAIN IN EXTREMITY (sore upper arm for 2.5 days) in a 46-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination.     Concurrent medical conditions included Rheumatoid arthritis and Dust allergy (Allergy to dust mites.). Concomitant products included HYDROXYCHLOROQUINE for Rheumatoid arthritis.    In November 2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. In November 2021, the patient experienced CHEST PAIN (atypical substernal chest sharp pain on day 1 then discomfort for about 6 days after that/fleeting stabbing pain in left anterior chest area, very deep/Also noted when she took a very deep inspiration/ Next few days, fleeting but never sharp again). November 2021, the patient experienced PAIN IN EXTREMITY (sore upper arm for 2.5 days). On an unknown date, the patient experienced CHEST DISCOMFORT (felt pressure around their heart and tightness around their heart) and CHEST DISCOMFORT (thoracic discomfort/Chest tightness/discomfort when she bent forward or rotated torso, which was intermittent). In November 2021, PAIN IN EXTREMITY (sore upper arm for 2.5 days) had resolved. On 19-Nov-2021, CHEST DISCOMFORT (felt pressure around their heart and tightness around their heart), CHEST DISCOMFORT (thoracic discomfort/Chest tightness/discomfort when she bent forward or rotated torso, which was intermittent) and CHEST PAIN (atypical substernal chest sharp pain on day 1 then discomfort for about 6 days after that/fleeting stabbing pain in left anterior chest area, very deep/Also noted when she took a very deep inspiration/ Next few days, fleeting but never sharp again) had resolved.        The action taken with mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown) was unknown.   For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown), the reporter considered CHEST DISCOMFORT (thoracic discomfort/Chest tightness/discomfort when she bent forward or rotated torso, which was intermittent) and CHEST PAIN (atypical substernal chest sharp pain on day 1 then discomfort for about 6 days after that/fleeting stabbing pain in left anterior chest area, very deep/Also noted when she took a very deep inspiration/ Next few days, fleeting but never sharp again) to be possibly related. No further causality assessments were provided for CHEST DISCOMFORT (felt pressure around their heart and tightness around their heart) and PAIN IN EXTREMITY (sore upper arm for 2.5 days).    GCP was going to run some lab tests and an EKG on the patient.  Patient received her first dose around  11/10/21. The evening of the vaccine, when she laid down in bed, she had fleeting stabbing pain and she had slept. All symptoms gradually improved qd. Denies exercise intolerance, PND, ankle edema, and by now she was nearly 100% back to baseline.  No treatment information was provided by the reporter.   Most recent FOLLOW-UP information incorporated above includes: On 22-Nov-2021: Follow-up received updated reporter contact detail. Updated patient demographics. Added medical history. Added start date (partial) of suspect product, added concomitant medication's route and dose description. Added events and outcomes.