This spontaneous report received from a patient concerned a 49 year old female of unspecified race and ethnicity. The patient's weight was 113 pounds, and height was 162.56 centimeters. The patient's pre-existing medical history included: The patient was healthy, thin, not overweight and no use of concomitant medications or vaccine, any immunomodulatory drugs, or steroids. The patient had no family history of immune disorders. The patient had no illness at the time of vaccination, no past history of similar event, no adverse event after any previous vaccination, no history of allergy to vaccine, drug, or food, no pre-existing acute illness 30 days prior to vaccination, no history of hospitalization in last 30 days, no significant family history of any disease (relevant to vaccination) or allergy, no suspected causes including co-administered vaccine(s)/risk factors. The patient was not pregnant at time of vaccination and was not breastfeeding. The patient previously received Covid-19 vaccine ad26.cov2.s (dose number in series: 1) (suspension for injection, route of admin not reported, and batch number: unknown, expiry: unknown) dose was not reported, 1 total, administered on JUL-2021 to right arm for prophylactic vaccination. On an unspecified date, in JUL-2021, 7 to 8 hours after vaccination the patient got so sick for an entire day it was like the flu, all of a sudden patient's neck got sore, the back of her neck, then her whole body hurt quickly, patient was in bed the entire next day, followed by coughing, and sore throat. The symptoms lasted for only 24 hours. On an unspecified date, in SEP-2021, 2 months after the vaccination, the patient got breakthrough infection from her 16 years old unvaccinated daughter. The patient got sick, about two days after her daughter got sick. It started slow but it was like a really bad flu, after the first couple of days. By day 4, that is on night of day 4, the patient had trouble breathing, not trouble that she could not get oxygen but she was scared what if it got worse and she needed it to go to the hospital. She never had temperature or maybe never noticed it because of the medication she was taking that is a lot of Thermax and Theraflu. She also experienced coughing and not much of a runny nose which lasted 8 days and she was back to normal on day 8. The patient also had really sore throat (suspected Covid-19 infection and suspected clinical vaccination failure) (dose number in series: 1). The patient took Nyquil and Dayquil. She did not want to take other medication as it had acetaminophen in it and did not want to get more double acetaminophen. The patient received booster dose of Covid-19 vaccine ad26.cov2.s (dose number in series: 2) (suspension for injection, route of admin not reported, batch number: unknown and expiry: unknown) dose was not reported, 1 total, administered on 04-JAN-2022 to right arm for prophylactic vaccination. The batch number was not reported and has been requested. No concomitant medications were reported. On an unspecified date in JAN-2021, the patient got sick for an entire day which was like the flu, she was so tired, and, she could hardly open her eyes, dosing on and off all day which lasted for 24 hours. On 05-JAN-2022, on morning when she woke up, the patient experienced her entire body hurt (dose number in series: 2). The action taken with Covid-19 vaccine ad26.cov2.s was not applicable. The patient recovered from sick, flu like symptoms, hardly open eyes, dosing on and off whole day, and tired on JAN-2022, and entire body hurt on 06-JAN-2022. This report was non-serious. This case, involving the same patient is linked to 20211265856. This case, from the same reporter is linked to 20220110608 and 20220110630.