inflammatory response to the vaccine; pain radiating from her thigh to her knee; excruciating pain; This spontaneous case was reported by a consumer and describes the occurrence of PAIN (pain radiating from her thigh to her knee) and PAIN (excruciating pain) in a 49-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch no. Unknown) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     Concurrent medical conditions included Pain in thigh (this pain had been ongoing since a couple of months before ) and Pain in knee (this pain had been ongoing since a couple of months before ).    On 10-Mar-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 10-Mar-2021, the patient experienced PAIN (pain radiating from her thigh to her knee) (seriousness criterion medically significant) and PAIN (excruciating pain) (seriousness criterion medically significant). On an unknown date, the patient experienced VACCINATION COMPLICATION (inflammatory response to the vaccine). The patient was treated with Surgery (spinal cord operation) for Pain and Surgery (spinal surgery) for Pain. At the time of the report, PAIN (pain radiating from her thigh to her knee), PAIN (excruciating pain) and VACCINATION COMPLICATION (inflammatory response to the vaccine) outcome was unknown.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On an unknown date, X-ray: did not reveal anything (normal) did not reveal anything.     mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown) was withdrawn on an unknown date.       Patient got the first dose of the Moderna COVID-19 vaccine in 10Mar2021 (she does not have the vaccination card now). Within 4 hours she experienced pain radiating from her thigh to her knee, this pain had been ongoing since a couple of months before but after the vaccine the pain magnified. Earlier the day of the shot she had had an X-ray that day did not reveal anything. But 4 hours after the shot she had excruciating pain that went on for several days. Her doctor felt she was having an inflammatory response to the vaccine. She tried steroids that did not work, it progressed and in 10Apr2021 she ended up with spinal surgery. Her neurologist did not want her to get second dose because of this reaction. She's feeling much better now. She never got the second shot and wants to know if she can take it or if the booster shot could take place of the second dose.  Her husband got the dose right before her, from the same lot and he was fine. She does not take any concomitant medications. Consent for Safety to follow up provided. Company comment: Very Limited information regarding the events has been provided at this time and a causal relationship cannot be excluded. However patient´s medical history of pain in thigh could be a confounder for the events. No further information is available for this case. The event were upgraded to serious by medical judgment because the need of surgery.; Sender's Comments: Very Limited information regarding the events has been provided at this time and a causal relationship cannot be excluded. However patient´s medical history of pain in thigh could be a confounder for the events.No further information is available for this case. The event were upgraded to serious by medical judgment because the need of surgery.