he woke up with hives/developed hives two nights ago; swelling; had an allergic reaction; feeling itchy; eyes were puffed up a little bit; feeling tired; This is a spontaneous report from a Pfizer sponsored program received from a contactable consumer (patient's father). A 14-year-old male patient received the second dose of BNT162b2 (PFIZER-BIONTECH COVID-19 VACCINE), on 08Jun2021 (at the age of 14-years-old) at dose 2, single for COVID-19 immunisation; started to receive amoxicillin on 21Jul2021 for tooth extraction. Medical history included fatty liver, the patient was on a fatty liver diet. Concomitant medications were not reported. The patient received the first dose of BNT162B2 on 17May2021, at the age of 14-years-old, for COVID-19 immunisation. 2nd dose received on 08Jun2021, no adverse event after receiving vaccine; the patient had a tooth extraction 9 days prior the report on 21Jul2021, since then he had swelling and allergic reaction and rushed to emergency room (ER) the day prior the report, on 29Jul2021; they told him, it was because he received BNT162b2. They gave him penicillin, no reaction following the vaccine, the reaction happened two days prior the report on 28Jul2021, started feeling itchy and he woke up with hives and they said that was the only thing different in his life. Patient had the tooth extraction, had amoxicillin and he had no reaction then. It was 2 days prior the report, on 28Jul2021 at night, that he started getting a little itchy and he woke up with hives. He developed hives two nights prior the report; they were trying to see if it would work itself out but it did not and they took him to ER and the reporter thought about what he had eaten; patient was on a fatty liver diet, on a healthy diet, so it was nothing in the food. The patient had been dieting, so he was got a pretty healthy diet so the only other event in his life recently was the vaccine. The only other variable would be the penicillin and the vaccine. They tried all day and near the evening they just took him to the emergency room and had him checked out and him having the vaccine was one of the variables they looked at causing it. Reporter asked if any children had developed an allergic reaction to penicillin and or the vaccine following the vaccine. The emergency room doctor, they could see the hives, they were puzzled at the same time, the only medicine recently he had taken was penicillin and slightly previously was the vaccine so they were trying to find connections. They gave the patient BENADRYL and it started going down last night prior the report. His eyes were puffed up a little bit, in Jul2021, he still had swelling. They gave him something different from BENADRYL, but he was not taken that yet so they were still dealing with this; he was still feeling tired in Jul2021. The reporter stated that he knew that it was really early but allergic reactions could be freaky. The action taken with amoxicillin was unknown. The patient had not recovered from swelling and feeling tired, the outcome of eyes were puffed up a little bit was unknown, the patient was recovering from the other events.   The lot number for the vaccine, BNT162B2, was not provided and will be requested during follow up.