This case was reported by a consumer via call center representative and described the occurrence of neuropathy in a 63-year-old male patient who received SHINGRIX for prophylaxis. The patient's past medical history included carcinoma brain (2 x survivor of brain cancer treated by chemotherapy and radiation treatment) and pneumonia. Previously administered products included ZOSTAVAX (couple of years ago), Vincristine with an associated reaction of neuropathy peripheral (administered as an infusion on the left arm lower side, after administration caused similar events as with SHINGRIX) and Flu vaccine with an associated reaction of no adverse event (vaccinated in the left arm). On 16th September 2018, the patient received the 1st dose of SHINGRIX (intramuscular) 50 µg. In September 2018, less than a week after receiving SHINGRIX, the patient experienced numbness. On 18th September 2018, the patient experienced fever. On 19th September 2018, the patient experienced neuropathy (serious criteria GSK medically significant), trouble falling asleep, throbbing pain and pain in joint involving shoulder region. On 22nd September 2018, the patient experienced nerve pain. The patient was treated with lidocaine hydrochloride (Lidocaine). On an unknown date, the outcome of the neuropathy, trouble falling asleep, throbbing pain and nerve pain were unknown and the outcome of the fever, pain in joint involving shoulder region and numbness were recovered/resolved. It was unknown if the reporter considered the neuropathy, fever, trouble falling asleep, throbbing pain, pain in joint involving shoulder region, numbness and nerve pain to be related to SHINGRIX. Additional information was reported as follows: The patient also added that he had a flu vaccine in the left arm in past and had not experienced any issues. On 16th September 2018 Sunday, the patient was vaccinated with the 1st dose of SHIHNGRIX. On 18th September 2018 Tuesday, the patient experienced fever. On 19th September 2018 Wednesday, the patient noticed that the pain. The pain started in his left shoulder joint like an arthritic pain. The patient used ice packs and heat to help with the same.  The patient stated that the pain resolved while the joint was numb because of the ice but returned after it was warmed back up, it lasted through 2 days then worsened by 22nd September 2018 (3rd day of pain). The pain then travelled went down to the nerves of his forearm and into the joints of his thumb.  The pain was throbbing, pulsating neuropathy like transcutaneous electrical nerve stimulation (TENS) unit, it was constant for last week before the date of reporting. The reporter noted that it was hard to sleep due to pain. The patient used Lidocaine patches to help with the pain. The patient was seen by the physician last week before the date of reporting. The patient had similar events in past after consumption of Vincristine, it was also received on the left arm but at a lower site as an infusion. The patient described it as the same tract of the pain, throbbing and pulsating as he was expiring at the time of reporting. The patient was seen by a doctor, last week before the date of reporting for the stated adverse events and also by an another doctor who was familiar with chemotherapeutic agents given in past.