I have asthma and breathing has been tighter/I noticed it is different when moving; tightness in chest; the (injection) site was a little bit sore; broke out in hives in both forearms/hives has spread all over body/head to toe and that is not only covered in hives but wounds caused by hives too.; hives has worsen in this 2 months; disruptive for my life; This spontaneous case was reported by a nurse and describes the occurrence of URTICARIA (broke out in hives in both forearms/hives has spread all over body/head to toe and that is not only covered in hives but wounds caused by hives too.), CONDITION AGGRAVATED (hives has worsen in this 2 months), FEELING ABNORMAL (disruptive for my life), DYSPNOEA (I have asthma and breathing has been tighter/I noticed it is different when moving) and CHEST DISCOMFORT (tightness in chest) in a 54-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 062E21A, 026L20A and 012M20A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     Concurrent medical conditions included Asthma and Diabetes.   On 03-Jan-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 31-Jan-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. On 25-Oct-2021, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. On 01-Nov-2021, the patient experienced URTICARIA (broke out in hives in both forearms/hives has spread all over body/head to toe and that is not only covered in hives but wounds caused by hives too.), CONDITION AGGRAVATED (hives has worsen in this 2 months) and FEELING ABNORMAL (disruptive for my life). On an unknown date, the patient experienced DYSPNOEA (I have asthma and breathing has been tighter/I noticed it is different when moving), CHEST DISCOMFORT (tightness in chest) and VACCINATION SITE PAIN (the (injection) site was a little bit sore). The patient was treated with FAMOTIDINE (PEPCID [FAMOTIDINE]) for Adverse event, at an unspecified dose and frequency; HYDROCORTISONE for Adverse event, at an unspecified dose and frequency and TRIAMCINOLONE for Adverse event, at an unspecified dose and frequency. At the time of the report, URTICARIA (broke out in hives in both forearms/hives has spread all over body/head to toe and that is not only covered in hives but wounds caused by hives too.) and CONDITION AGGRAVATED (hives has worsen in this 2 months) had not resolved and FEELING ABNORMAL (disruptive for my life), DYSPNOEA (I have asthma and breathing has been tighter/I noticed it is different when moving), CHEST DISCOMFORT (tightness in chest) and VACCINATION SITE PAIN (the (injection) site was a little bit sore) outcome was unknown.        For mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular), the reporter did not provide any causality assessments.   Concomitant medications details were not reported by the reporter. Treatment details also included Inhaler for chest tightness and Antihistamines (type 1), topical creams. It was reported that seven days after that, patient broke out in hives in both forearms over next few weeks and months hives had spread all over body. Patient said hives got really significant, from head to toe and that was not only covered in hives but wounds caused by hives too. It had been 2 months and patient said that hives had worsen in 2 months.