Stomach ache; body aches; Chills; awful headache; fever; The initial case was missing the following minimum criteria: other-LP agreement requiring source exchange-pending assessment back. Upon receipt of follow-up information on 04Feb2021, this case now contains all required information to be considered valid.  This is a spontaneous report from a contactable consumer based on information received by Pfizer from Bristol-Myers Squibb (manufacturer control number US-BRISTOL-MYERS SQUIBB COMPANY-BMS-2021-012629), license party for apixaban (ELIQUIS).  This spontaneous case was reported by a consumer and describes the occurrence of PYREXIA (fever), ABDOMINAL PAIN UPPER (Stomach ache), PAIN (body aches), CHILLS and HEADACHE (awful headache) in 84-year-old female patient who received apixaban (Eliquis) for an unknown indication. CO-SUSPECT PRODUCTS included Covid-19 Vaccine for COVID-19 prophylaxis. The patient's past medical history included Cardiac pacemaker insertion. Concurrent medical conditions included Breathing difficult and Blood pressure high (sometimes she has high blood pressure but not all the time). On an unknown date, the patient started Eliquis (unknown route). In January 2021, the patient started Covid-19 Vaccine (unknown route) first dose, one injection. On 31-Jan-2021, the patient experienced PYREXIA (fever), PAIN (body aches), CHILLS and HEADACHE (awful headache). On an unknown date, the patient experienced ABDOMINAL PAIN UPPER (Stomach ache). The patient was treated with paracetamol (Tylenol 8 Hour) for Generalised aching, at a dose of two at a time, 650mg. The action taken with Eliquis(Unknown) was unknown. At the time of the report, PYREXIA, ABDOMINAL PAIN UPPER, PAIN, CHILLS and HEADACHE outcome was unknown. DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On an unknown date, Body temperature: 100 to 99 to 98. For Eliquis(Unknown), the reporter did not provide any causality assessments. Concomitant medication: she was on about 4-5 medications. The reporter stated that she and her husband went somewhere to have their first COVID-1 9 vaccine, and are due again for the second dose on 11-Feb-2021 which was next Thursday. She had been having a reaction, and they called the paramedics but they said that there was no need to take her to the hospital, and knew what it was, when the paramedics came they checked her and said she was ok, her temperature went from 100 to 99 to 98, and they said that her heart checked out ok and if she were to go to the hospital they would keep her overnight, run some tests then take her back home. She had fever, stomachache, and body aches. he was told to take Tylenol and drink lot of liquids. She said she wondered if it was a reaction, because she was sick, with aching arms, and aches all over, and she was wondering if she should get second shot. Height: she was taller, as she gets older she was shrinking, she thinks. She said she got her first dose in her left arm at around 12:45 Pm. She said that after the first dose she had a fever on Sunday, and an awful headache, and chills and aches all over, it wasn't fun, for treatment she had been taking Tylenol for pain, it was all she could take. She said she had a pacemaker, so she wanted to call and make sure of everything. Reporter stated that she gets 60 pills of Eliquis at a time. She has got a breathing machine.