Hands swollen and sore to touch with pain going up the arm; Hands swollen and sore to touch with pain going up the arm; Preventing him from being able to perform his activities of daily living; His ankles are now bothering him as well "to where he can hardly walk."; His ankles are now bothering him as well "to where he can hardly walk."; This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP) from medical information team.  A 76 year-old male patient received bnt162b2 (COMIRNATY), administered in arm left, administration date 15Sep2021 (Lot number: FE3592) at the age of 76 years as dose 2, single for covid-19 immunisation. Relevant medical history included: "Influenza A", start date: 2017 (unspecified if ongoing), notes: He was diagnosed with Influenza A in 2017 too and was in the ICU for a week.; "Parkinson's", start date: 2019 (unspecified if ongoing), notes: Parkinson's was diagnosed in 2019, and he had tremors in right hand only and not his left hand.; "Tremors" (unspecified if ongoing), notes: Clarified to he has tremors in right hand only and not his left hand. Family history included: "aneurysm" (unspecified if ongoing), notes: His sister had an aneurysm and is in long term care; "MS" (unspecified if ongoing), notes: another sister has MS; "Alzheimer's" (unspecified if ongoing), notes: his mom had Alzheimer's. Concomitant medication(s) included: XARELTO taken for anticoagulant therapy; ASPIRIN; CENTRUM MULTIGUMMIES; VITAMIN B12; FOLIC ACID; ROSUVASTATIN; MELATONIN; LINZESS taken for irritable bowel syndrome. Vaccination history included: Bnt162b2 (Dose: 1, Dosage text: first dose injected in left arm, LOT: FC3181), administration date: 10Aug2021, when the patient was 76 years old, for COVID-19 Immunization, reaction(s): "first shot didn't do nothing to him". The following information was reported: PERIPHERAL SWELLING (non-serious), PAIN IN EXTREMITY (non-serious) all with onset 30Sep2021, outcome "not recovered" and all described as "Hands swollen and sore to touch with pain going up the arm"; LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (non-serious) with onset 2021, outcome "unknown", described as "Preventing him from being able to perform his activities of daily living"; ARTHRALGIA (non-serious), GAIT DISTURBANCE (non-serious) all with onset 2021, outcome "unknown" and all described as "His ankles are now bothering him as well "to where he can hardly walk."". The events "hands swollen and sore to touch with pain going up the arm", "hands swollen and sore to touch with pain going up the arm", "preventing him from being able to perform his activities of daily living", "his ankles are now bothering him as well "to where he can hardly walk."" and "his ankles are now bothering him as well "to where he can hardly walk."" were evaluated at the physician office visit. Relevant laboratory tests and procedures are available in the appropriate section. Therapeutic measures were not taken as a result of peripheral swelling, pain in extremity, loss of personal independence in daily activities, arthralgia, gait disturbance.  Additional information: She says her husband's first shot didn't do nothing to him, he had no hurt arm, then the second shot he had no painful arm then 15 days later he had two swollen hands, which he still does to this day. She says he has some testing coming up. Caller asking if the swelling and pain in the arms and hands could be a side effect from Comirnaty. Caller states her husband had seen a primary care doctor and a cardiologist after these symptoms started. Patient went to PCP and they had him open and shut his fist, and she took him to his cardiologist who recommended a CT scan after a chest x-ray that didn't show anything, a CT with contrast to see what was going on. She says they said he was supposed to go in for arterial or arterial venous something and a doppler of his upper arms. Caller states the primary care doctor said she doesn't think his symptoms were related to Comirnaty, but the caller states she was not convinced. Caller also mentioned that her husband has to have a CAT scan and she thinks his care is being delayed. Caller says her husband didn't take anything to treat the swelling and pain because he was on a blood thinner and aspirin, so if he took pain medication she would really have to watch him for bleeding. She says her husband takes a multivitamin, clarified to just regular chewy Centrum, two MultiGummies things in morning, which he had not been taking that really since his hands had been swollen. Caller says that at first they asked his doctor if any of his medications he was taking could cause this and his doctor said no.  No follow-up attempts are possible. No further information is expected.