calcium build up on the outside of her arteries; both shoulders rotator cuff tears; cataract surgery; slight twinge in her heart area; rash; some darkness that was fingering out where the medicine was / dark fingering; started having swelling in her left knee; started having swelling in her left knee and it was extremely painful; The initial safety information received was reporting only non-serious adverse drug reaction(s). Upon receipt of follow-up information on 08Feb2022, this case contains serious adverse reaction(s) and all safety information is processed together.  This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP). The reporter is the patient.  A 70 year-old female patient received bnt162b2 (BNT162B2), intramuscular, administered in deltoid left, administration date 09Mar2021 01:00 (Lot number: EN6201, Expiration Date: Jun2021) at the age of 70 years as dose 2, single for covid-19 immunisation. Relevant medical history included: "Blood pressure" (unspecified if ongoing), notes: controlled with medicine; "Stage 3 kidney disease" (unspecified if ongoing); "artificial knees" (unspecified if ongoing); "Osteoarthritis" (unspecified if ongoing). Concomitant medication(s) included: CARVEDILOL; ATORVASTATIN (ongoing); OXYCODONE (ongoing); AMITRIPTYLINE (ongoing). Past drug history included: Naproxen, reaction(s): "stage 3 kidney disease". Vaccination history included: Bnt162b2 (Dose 1, time: 1:00, lot 9262, expiration date May2021, left shoulder, Intramuscular), administration date: 09Feb2021, when the patient was 70 years old, for COVID-19 Immunization, reaction(s): "rash on her shoulder", "tired after 04Mar2021.", "dark fingering to her elbow". The following information was reported: ANGINA PECTORIS (disability, medically significant) with onset 12Apr2021, outcome "not recovered", described as "slight twinge in her heart area"; CATARACT (disability, medically significant) with onset 23Jun2021, outcome "not recovered", described as "cataract surgery"; RASH (disability) with onset 2021, outcome "not recovered", described as "rash"; VACCINATION SITE DISCOLOURATION (disability) with onset 2021, outcome "not recovered", described as "some darkness that was fingering out where the medicine was / dark fingering"; JOINT SWELLING (disability) with onset 2021, outcome "not recovered", described as "started having swelling in her left knee"; ARTHRALGIA (disability) with onset 2021, outcome "not recovered", described as "started having swelling in her left knee and it was extremely painful"; ROTATOR CUFF SYNDROME (disability) with onset 08Jul2021, outcome "not recovered", described as "both shoulders rotator cuff tears"; ARTERIOSCLEROSIS (disability), outcome "not recovered", described as "calcium build up on the outside of her arteries". The events "slight twinge in her heart area", "both shoulders rotator cuff tears" and "calcium build up on the outside of her arteries" were evaluated at the physician office visit. Patient had had no trouble after any of the vaccines other than a rash on the top of her shoulder for about a week and then some darkness that was fingering out where the medicine was. 12Apr2021 patient went to a Cardiologist, because of slight tingles in her heart area. He scheduled an Echo and several other tests on May2021, patient saw again for more testing, gave her the results. He said her heart was strong but she had calcium build up on the outside of her arteries. He handed her a bottle of Nitro and said if the pain she was having, got worse and stayed longer, to place one under her tongue and go to the hospital. Patient had not had to lose one she had a follow up appointment on 15Feb2022 of his office. 04Mar2021 (also reported as 09Mar2021), she got her second Covid shot at the same place. She was not as tired, but still had a rash at the top of her shoulder. that lingered a couple of week & the dark fingering. In between this and started having swelling in her left knees and it was extremely painful. 23Jun2021, patient had a cataract surgery. Everything was normal for the surgery. 08Jul2021 patient went to a shoulder check she had both shoulders rotator cuff tears, full. Patient had cortisone shots, in each shoulder. Patient went back 26Aug2021 and told the Dr. that helped with the pain in her shoulder. 31Aug2021 follow up. Everything stayed the same. The patient underwent the following laboratory tests and procedures: blood test: (2021) unknown results; echocardiogram: (12May2021) unknown results; electrocardiogram: (2021) unknown results. Therapeutic measures were taken as a result of angina pectoris, cataract, joint swelling, arthralgia, rotator cuff syndrome, arteriosclerosis.