lost a ton of weight - almost 80 pounds; Caller states she was really really really sick. Caller mentioned after her first dose of vaccine she was just very deathly ill; Caller states she was really really really sick. Caller mentioned after her first dose of vaccine she was just very deathly ill; wasn't hungry; couldn't eat anything; This is a spontaneous report from a contactable consumer (patient). A 31-year-old female patient received first dose of BNT162B2 (PFIZER-BIONTECH COVID-119 VACCINE, Solution for injection, Lot number: ER8731) via unknown route of administration on 20Apr2021 in left arm as dose 1 single for COVID-19 immunization. Medical history included lupus (diagnosed since age 16, about 14 years ago they think it spiked around age 14 but it was not diagnosed until age 16), Ehlers-Danlos syndrome (started around age 18 or 19 She has had it her whole life and they didn't know what was going on with her but was diagnosed at age 18 or 19), Fibromyalgia (Since age 16), Ulcerative colitis (around age 16), Migraine (age 16 to 18), post tachycardia syndrome (diagnosed age 24 or 25 but thinks it started with lupus Caller states also called POTS (Postural orthostatic tachycardia syndrome)), narcolepsy and cataplexy (diagnosed around age 23 or 24), Raynauds (diagnosed around age 16), Sjogren's (diagnosed around age 16), Empty sella syndrome from 2019 (doctors are going back and forth about it because it might be something else. They diagnosed her but are confused about what is going on - thinks its from Chiari Malformation which goes with Ehlers Danlo's Syndrome, but her Chiari Malformation isn't bad enough to do surgery, so they are saying just wait and see if it gets really bad) all are ongoing. Family history included heart disease and ongoing Ehlers-Danlos syndrome (Ehlers Danlos is rapid through family). No prior vaccinations (within 4 weeks). Concomitant medications included ongoing hydroxyzine pamoate orally at 25 mg (extended release, take 1-2 capsules by mouth at night, started in 2018 or 2019; states dose is usually one, sometimes two, depending on how swollen her brain feels) for to sleep and relax, because of all the inflammation, ongoing tramadol at 50 mg, take 1 by mouth every four hours as needed for pain (Only takes when severe Started at age 18) for needed for pain, ongoing cyclobenzaprine orally at 10 mg, as needed for muscle relaxer (since age 18 Only takes it when she can't handle it anymore), methotrexate orally from unknown date to 20Apr2021 at 25 mg, Take 3 tablets by mouth every Sunday for immunosuppressant, prednisone from unknown date to 20Jun2021 at unknown dose (had her go off of this medication since methotrexate. Has taken medicine on again and off again since age 16) for inflammation off brain and on birth control. Patient previously took Flu Vaccine and just got sick for about a week and then got better. It was reported that patient stated she lost a ton of weight after this and that was the other side effect. She lost almost 80 pounds on 20Apr2021. Patient stated she was really really really sick in 2021. patient mentioned after her first dose of vaccine she was just very deathly ill and it took about a week in 2021. Lost a ton of weight - almost 80 pounds: patient stated the weight started coming off with the first vaccine. patient stated she was now holding constant weight. She couldn't eat anything and wasn't hungry at all but started getting her hunger back in 2021. Patient underwent labs and procedure included Blood test on 25Jun2021: unknown results. The outcome of events eating disorder and appetite absent was recovering, while for other events was unknown.  No follow-up attempts are possible. No further information is expected.