This spontaneous case was reported by a patient and describes the occurrence of LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (can't drive/shift gear/was difficult and painful, debilitating/can't comb or dry hair, pour water from pot, deep pain in joint/can't turn doorknobs/hold a phone to ear), MUSCULAR WEAKNESS (severe weakness in the left elbow and minor in right elbow, now shifted to the right elbow and minor in the left elbow), MUSCULOSKELETAL DISCOMFORT (Severe discomfort in the left elbow/minor in the left elbow/shifted to the right elbow), PAIN (severe pain) and MOBILITY DECREASED (can't drive, can't shift gear/ can't comb or dry hair, can't pour water from a pot, can't carry a gallon, can't lift can't squeeze, can't turn doorknobs, can't hold a phone to ear) in a 57-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 061E21A and 053E21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below. The patient had no past medical history and no known allergies. The patient never had COVID positive test or diagnosis. No other vaccines were given to the patient within 1 month prior to Moderna COVID-19 vaccine. On 01-Sep-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) .5 milliliter. On 02-Oct-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to .5 milliliter. In March 2022, the patient experienced STREPTOCOCCAL INFECTION (diagnosed with Strep). On 23-Mar-2022, the patient experienced ANOGENITAL WARTS (diagnosed with genital warts and doesn't have HPV and warts were frozen). In May 2022, the patient experienced SPONDYLOLISTHESIS (patient developed pain in back and was diagnosed with Spondylolisthesis). On an unknown date, the patient experienced LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (can't drive/shift gear/was difficult and painful, debilitating/can't comb or dry hair, pour water from pot, deep pain in joint/can't turn doorknobs/hold a phone to ear), MUSCULAR WEAKNESS (severe weakness in the left elbow and minor in right elbow, now shifted to the right elbow and minor in the left elbow), MUSCULOSKELETAL DISCOMFORT (Severe discomfort in the left elbow/minor in the left elbow/shifted to the right elbow), PAIN (severe pain), MOBILITY DECREASED (can't drive, can't shift gear/ can't comb or dry hair, can't pour water from a pot, can't carry a gallon, can't lift can't squeeze, can't turn doorknobs, can't hold a phone to ear), WEIGHT BEARING DIFFICULTY (can't carry a gallon/she has to hold it with 2 hands) and ARTHRALGIA (severe pain, in the left elbow/minor in right elbow/ pain is deep in the joint/can't shift gear it is difficult and painful). The patient was treated with MUPIROCIN for Streptococcal infection, at an unspecified dose and frequency and IBUPROFEN for Pain, at a dose of 600 mg as needed, but doesn't work. At the time of the report, LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (can't drive/shift gear/was difficult and painful, debilitating/can't comb or dry hair, pour water from pot, deep pain in joint/can't turn doorknobs/hold a phone to ear), MUSCULAR WEAKNESS (severe weakness in the left elbow and minor in right elbow, now shifted to the right elbow and minor in the left elbow), MUSCULOSKELETAL DISCOMFORT (Severe discomfort in the left elbow/minor in the left elbow/shifted to the right elbow), PAIN (severe pain), MOBILITY DECREASED (can't drive, can't shift gear/ can't comb or dry hair, can't pour water from a pot, can't carry a gallon, can't lift can't squeeze, can't turn doorknobs, can't hold a phone to ear), WEIGHT BEARING DIFFICULTY (can't carry a gallon/she has to hold it with 2 hands) and ARTHRALGIA (severe pain, in the left elbow/minor in right elbow/ pain is deep in the joint/can't shift gear it is difficult and painful) had not resolved and STREPTOCOCCAL INFECTION (diagnosed with Strep), ANOGENITAL WARTS (diagnosed with genital warts and doesn't have HPV and warts were frozen) and SPONDYLOLISTHESIS (patient developed pain in back and was diagnosed with Spondylolisthesis) had resolved. No concomitant medications were reported. The patient reported side effects months after receiving the 2nd dose of the Moderna vaccine and stated 2-3 months after receiving the vaccine experienced severe weakness, pain, and discomfort in the left elbow and minor in right elbow which now had shifted to the right elbow and minor in the left elbow. The patient stated that this was difficult as she was right handed. The patient now could not drive, could not shift gear it was difficult and painful, debilitating, could not comb or dry hair, could not pour water from a pot, the pain was deep in the joint, could not carry a gallon, and had to hold it with 2 hands, could not lift could not squeeze, could not turn doorknobs, could not hold a phone to ear, this was taking a toll on the patient. As per the patient, Moderna had compromised her body's integrity. Reportedly, the patient was very active and powerwalked, had no problems, and doesn't look her age. The patient currently did not had a diagnosis but was having an upcoming appointment with an Orthopedic doctor, and would update the information after the visit. After a few misdiagnoses, in Mar-2022 patient was diagnosed with Strep, which typically happened in children and in May, patient developed pain in back and was diagnosed with Spondylolisthesis, which typically happened in children. These symptoms had resolved. The patient had taken medication for the pain but it doesn't seemed to work. Treatment medication information provided also included Gel.