more seizure/partial seizure disorder worse since 2nd vaccine/meds not working; more seizure/partial seizure disorder worse since 2nd vaccine/meds not working; dizziness; sore arm; fatigue; This spontaneous case was reported by a consumer (subsequently medically confirmed) and describes the occurrence of PARTIAL SEIZURES (more seizure/partial seizure disorder worse since 2nd vaccine/meds not working), CONDITION AGGRAVATED (more seizure/partial seizure disorder worse since 2nd vaccine/meds not working), DIZZINESS (dizziness), PAIN IN EXTREMITY (sore arm) and FATIGUE (fatigue) in a 72-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 016M20A and 025L20A) for COVID-19 vaccination.     Concurrent medical conditions included Partial seizures since 15-Jun-1970, Allergy to antibiotic (keflex), Allergy to antibiotic (Nizoral), Allergy to antibiotic (Septra), Allergy to antibiotic (Macrobid), Allergy to antibiotic (Levaquin) and Allergy to antibiotic (Tamiflu). Concomitant products included VALPROATE SEMISODIUM (DEPAKOTE SPRINKLE) and CLORAZEPATE DIPOTASSIUM (TRANXENE) for Partial seizures.   On 25-Jan-2021 at 8:30 PM, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 22-Feb-2021 at 8:30 PM, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 23-Feb-2021, the patient experienced PAIN IN EXTREMITY (sore arm) and FATIGUE (fatigue). On 24-Feb-2021, the patient experienced PARTIAL SEIZURES (more seizure/partial seizure disorder worse since 2nd vaccine/meds not working) and CONDITION AGGRAVATED (more seizure/partial seizure disorder worse since 2nd vaccine/meds not working). 24-Feb-2021, the patient experienced DIZZINESS (dizziness). At the time of the report, PARTIAL SEIZURES (more seizure/partial seizure disorder worse since 2nd vaccine/meds not working), CONDITION AGGRAVATED (more seizure/partial seizure disorder worse since 2nd vaccine/meds not working) and DIZZINESS (dizziness) had not resolved and PAIN IN EXTREMITY (sore arm) and FATIGUE (fatigue) outcome was unknown.            No treatment medications were reported.  The patient experiencing more than 3 months after the 2nd dose was both entirely new ongoing dizziness  and distressingly familiar  an exacerbation of my partial seizure disorder. The patient had a hard time functioning.  The anti-seizure medications the patient had been taking for almost 30 years are no longer reliably controlling my symptoms. The patient was working with neurologist, have had lots of blood work, an MRI, and the patient ow been referred back to the Epilepsy Center for further follow-up.  The patient had been healthy and very active with an unusual but well controlled partial seizure disorder, but now patient really struggling.  Based on current available information and the temporal association between product use and the start date of the events a causal relationship cannot be excluded.   Most recent FOLLOW-UP information incorporated above includes: On 06-May-2021: Patient demographics, medical history, lab data, concomitant drug indication, route of administration, dosage, event onset date for dizziness were updated; added new events.; Sender's Comments: Based on current available information and the temporal association between product use and the start date of the events a causal relationship cannot be excluded.