tested positive on the 17Mar2022, by rapid test; tested positive on the 17Mar2022, by rapid test; This is a spontaneous report received from contactable reporter(s) (Other HCP) from product quality group for a Pfizer sponsored program.  A 79 year-old male patient received bnt162b2 (BNT162B2), administration date 24Sep2021 (Lot number: 39308A) at the age of 78 years as dose 3 (booster), single, administration date 22Feb2021 (Lot number: EN6198) as dose 2, single and administration date 31Jan2021 (Lot number: EL9262) as dose 1, single for covid-19 immunisation. Relevant medical history included: "Hypercholesterolemia" (unspecified if ongoing), notes: type II, genetic form, apart of the first clinical trial for the first statin drug.; "Arthritis" (unspecified if ongoing), notes: Arthritis, several years ago, probably 19 years ago, after turning 60 years old.; "Stiff heart syndrome", start date: Dec2021 (unspecified if ongoing), notes: Stiff heart syndrome, diagnosed with a stress test and echo cardiogram. Concomitant medication(s) included: CRESTOR taken for hypercholesterolemia; CELEBREX taken for arthritis; TYLENOL taken for arthritis.  The following information was reported: VACCINATION FAILURE (medically significant), COVID-19 (medically significant) all with onset 17Mar2022, outcome "unknown" and all described as "tested positive on the 17Mar2022, by rapid test". The patient underwent the following laboratory tests and procedures: sars-cov-2 test: (17Mar2022) positive, notes: Result: positive; Unit: Not Provided.  Clinical course: Reporter was calling for her husband, she had a medical question, he had started taking Paxlovid last night and he was taking Crestor, wants to know if he can continue taking Crestor because he already started taking Paxlovid. Crestor was not listed on the medicine contraindicated for Paxlovid, on the safety information. Husband was 79 years old. Reporter stated there were two statins listed on safety information. Safety information fact sheet says did not take Paxlovid if taking Lovastatin or Simvastatin. That was only two of the statin drugs, assuming potential side effects with the liver. Reporter was curious why only those two statins. She tired to find the information online and could not find what she was looking for. Her husband just started the Paxlovid last night, Dr. with held colleague, interacted via text message, colleague ordered monoclonal antibodies because of her husbands age. The infusion nurse said Paxlovid was the first choice, the nurse was the one to put them in direction of the Paxlovid. Reporter did the research for the Paxlovid, text messaged with physician who wanted to use Paxlovid. So reporter sent her the link to the website. Her husband tested positive on the 17Mar2022, by rapid test, with symptoms. He had classic symptoms, he had gotten better, remarkably, Friday was like a brick hit him, by Monday much better, assumes he had omicron, because he was totally vaccinated and boosted. None of the ones contraindicated. He did not had high blood pressure, not morbidly obese, very active, fit. He takes other drugs for cholesterol but they were not statins. Medical History included Hypercholesterolemia diagnosed 40 years ago, nobody took cholesterol seriously then, his was over 400 and he 38 years old. He was told he wouldn't live to be 50 years old and that was almost 30 years go. No historical NDC/lot/expiration for previous statin drugs taken which he has been taking for 47 years., it was 20 years ago. He takes other things not interacting with Paxlovid. Stiff heart syndrome stress EKG done medically, with arthritis he can't walk that much. Investigations: no testing, paperwork says patient can have liver issues, with statin drugs but that's why he shouldn't take those two specific statins. Reporter wanted to know if okay to take Crestor with Paxlovid.  Additional Information for Other medicines Crestor: Started when it first came on the market. He was switched from another statin drug. The clinic stopped being involved. Probably 20 years ago.  No follow-up attempts are possible. No further information is expected.