sick; the arm ached; massive headache; extremely tired; weak; This is a spontaneous report received from non-contactable reporter(s) (Consumer or other non HCP). The reporter is the patient.  A 59-year-old female patient received BNT162b2 (BNT162B2), in May2021 as dose 1, single (Batch/Lot number: unknown) at the age of 59 years for covid-19 immunisation. The patient's relevant medical history included: "car accident" (unspecified if ongoing); "Drug allergy" (unspecified if ongoing); "diabetes type II" (unspecified if ongoing); "hypothyroidism" (unspecified if ongoing), notes: underactive thyroid; "hiatal hernia" (unspecified if ongoing); "depression" (unspecified if ongoing); "anxiety" (unspecified if ongoing); "tremors" (unspecified if ongoing); "penicillin allergy" (unspecified if ongoing); "GERD" (unspecified if ongoing); "hearing impairment" (unspecified if ongoing); "walker user" (unspecified if ongoing); "cane user" (unspecified if ongoing); "vitamin d low" (unspecified if ongoing); "pain in back" (unspecified if ongoing); "pain in neck" (unspecified if ongoing); "acid reflux" (unspecified if ongoing); "legs cramp" (unspecified if ongoing); "overactive bladder" (unspecified if ongoing); "inflammation" (unspecified if ongoing); "migraines" (unspecified if ongoing); "lost consciousness" (unspecified if ongoing); "does not sleep" (unspecified if ongoing); "body feels run down" (unspecified if ongoing); "Vasosin allergy" (unspecified if ongoing). Concomitant medication(s) included: PANTOPRAZOLE; BACLOFEN; PREGABALIN; BUSPIRONE; ROPINIROLE; METFORMIN; VITAMIN D3; VITAMIN B12 [CYANOCOBALAMIN]; CURCUMA LONGA; VITAMIN C [ASCORBIC ACID]; LEVOTHYROXINE; OMEPRAZOLE; DIPHENHYDRAMINE; OXYBUTYNIN; FLUTICASONE PROPIONATE; AZELASTINE HYDROCHLORIDE; ALLOPURINOL; ACETAMINOPHEN; VITAMIN B COMPLEX; APPLE CIDER VINEGAR; MALUS SPP.. Past drug history included: Bextra, reaction(s): "bextra allergy"; Motrin, reaction(s): "Motrin allergy". The following information was reported: FATIGUE (non-serious) with onset May2021, outcome "recovered" (May2021), described as "extremely tired"; HEADACHE (non-serious) with onset May2021, outcome "recovered" (May2021), described as "massive headache"; ILLNESS (non-serious) with onset May2021, outcome "recovered" (May2021), described as "sick"; PAIN (non-serious) with onset May2021, outcome "recovered" (May2021), described as "the arm ached"; ASTHENIA (non-serious) with onset May2021, outcome "recovered" (May2021), described as "weak". Therapeutic measures were taken as a result of illness, pain, headache, fatigue, asthenia.  Additional Information: Patient was reported that she experienced after both injections, the patent became sick. Sick was further clarified as, the arm ached (on the second day); had a massive headache; was extremely tired; and weak, start dates May2021, outcomes resolved. After the first injection, side effects ended after about 4 days. After the second injection, the symptoms were more severe and lasted longer (lasted about 5 days). Tylenol or nothing else (not further clarified) would not help the headache. The headache felt like a migraine and regular headache combined. After the second injection, the patient slept about 24-48 hours. The patient was so weak, that it was difficulty getting out of the bed. The patient treated her symptoms with a sports drink that had electrolytes. The patient must wait 2-3 weeks after her 01Jun2021 injection (2nd Pfizer vaccine) before she receives her next Ocrevus infusion.  No follow-up attempts are possible; information about lot/batch number cannot be obtained. No further information is expected.