he had aortic stenosis; Shot #3 was somewhat feeling worse a couple days but cleared up and felt 100% in about 3 days.; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP) from medical information team, Program ID. The reporter is the patient.  A 68-year-old male patient received BNT162b2 (BNT162B2), on 04Oct2021 as dose 3 (booster), single (Lot number: FF8839) at the age of 67 years for covid-19 immunisation. The patient's relevant medical history included: "Cholesterol" (unspecified if ongoing), notes: cholesterol drug; "blood pressure crisis" (unspecified if ongoing); "smoking" (unspecified if ongoing); "diastolic disfunction" (unspecified if ongoing); "weak heart/ heart issue" (unspecified if ongoing). Concomitant medication(s) included: ALLOPURINOL; BABY ASPIRIN; BUPROPION taken for smoking cessation therapy. Vaccination history included: BNT162b2 (Dose: 1, Lot number:EN9581), administration date: 11Feb2021, when the patient was 67-year-old, for COVID-19 immunization, reaction(s): "chills"; BNT162b2 (Dose: 2, Lot number:EN6198), administration date: 04Mar2021, when the patient was 67-year-old, for COVID-19 immunization, reaction(s): "he was quite under the weather for a day and a half"; Flu shot (gets the flu shot he gets a little chill but it's never a problem), for Immunization, reaction(s): "he gets a little chill"; Flu shot (He is sensitive to any flu shot anyways but not like this), for immunization, reaction(s): "Sensitive"; Had tons of shots (had tons of shots), for immunization; Plague, for immunization, reaction(s): "Reaction"; Typhoid, for immunization, reaction(s): "Reaction". The following information was reported: AORTIC STENOSIS (medically significant), outcome "unknown", described as "he had aortic stenosis"; FEELING ABNORMAL (non-serious), outcome "unknown", described as "Shot #3 was somewhat feeling worse a couple days but cleared up and felt 100% in about 3 days.". The patient underwent the following laboratory tests and procedures: SARS-CoV-2 test: Negative, notes: He never tested positive. Clinical course: Patient received two shot original vaccine and both booster and considering getting the Omicron booster. concern was he had a progressively strong response from each shot. The last one caused him to be in bed for three days, and did not feel good for about a week. Patient had questions about Paxlovid and side effects but didn't mention if he was prescribed, they were general questions. Patient States with shot number 1 he was pretty asymptomatic, he may have had chills that night. Anytime he gets the flu shot he gets a little chill but it's never a problem. After shot 2 he was quite under the weather for a day and a half. Shot 3 was somewhat feeling worse a couple days but cleared up and felt 100% in about 3 days. Shot 4 he was in bed 3 days pretty much and didn't feel 100% for a week. His concern is where is that going. If it wasn't progressive, if it was the same response every time it wouldn't concern him. Patient Is not afraid to get omicron one but considering why would he take the chance of 3-4 days in bed sick when he could just take oral medication if he comes down with it, he wouldn't be worse off. His wife tested positive for COVID and was asymptomatic and they slept together forever. He never tested positive, and he has been exposed a couple other times and if he ever had it was very mild or he was asymptomatic. One more caveat with Paxlovid, he takes some medication for his heart, for weak heart, diastolic disfunction. Last Nov he had catheter and they installed in the aortic well, it's an artificial valve they put in through a catheter through the femoral artery. He was in and out of the hospital and was there 1 night. They have not used this on younger people, he had aortic stenosis, an occlusion causing problems. He feels good but it sounds crazy, but he did hear there were interactions between some heart medications and Paxlovid and is not sure if they are rumor. He takes a couple of different blood pressure medications. He wouldn't have any trouble not using them for a week, he doesn't know. He could probably ask his family physician and suspects he will lay this all out and he will say it's up to him. He is not really looking for strong answers, just trying to sort through. What has got him disturbed is having worse reactions, as progresses more robust reactions. If he is going to be sick 3-5 days he may as well take a chance, he has been exposed .Knows we are not going to say yes take it or no don't take it. He is trying to establish some kind of level of risk.Is just looking to hear if anyone else is having these problems or if we recommend not taking. It's just the response he has, it's not an allergic reaction. In medical sense he is sure it would be labeled as mild reaction but to him it's more toward moderate more like flu. He is sensitive to any flu shot anyways but not like this. After the 4th dose Pfizer COVID-19 vaccine it was about hardest part of it, he doesn't know if he was sick a little earlier. With the other 3 it was about 12 hours after getting the vaccine and the last one may have been 6-8 hours after. Outcome reported as It definitely started improving after 3 days and he felt 100% after a week. He takes several every day including a few blood pressure medications, allopurinol, cholesterol drug, baby aspirin and he just started taking Bupropion. States he started the Bupropion after all of this happened. It's for smoking but he was having blood pressure crisis a few months back and got on extra blood pressure medications and gave him a script for that and it made him calm a little. Declines to provide further details. He would assume that someone would flag his profile if he was getting an interaction and he got a couple through the pharmacy, and no one said anything about interaction. Medical Condition reported as just the heart issue. Had the procedure on 29Nov2021. Additional vaccines administered on Same Date of the Pfizer Suspect reported as none. Adverse Event (AE) the time of onset of AE(s) reported within 6-8 hours. Patients visit to emergency room and physician office reported as no. Prior Vaccinations (within 4 weeks) reported as none. AE(s) following prior vaccinations reported as Flu vaccine. last 2 he got were for old timers, the bivalent for seniors. Has had every vaccination known to man. Was in # and had tons of shots, got every shot you could think of. He got a little reaction because he got 5 in 1 shot and they were all different, the plague, typhoid the whole 9 years. States nothing reportable or to be concerned about. Had signed up for flu shot and omicron shot when he got there, they said flu but not Omicron their vaccine got too warm. He mentioned really and truly he gets a reaction and is glad it was not both at once. That it might not be bad to wait a couple weeks. The progression of the shot's response has him a little troubled, some people say it's a good thing. He is still looking for data and will contact his family physician. There are no real answers, but this been couple years so someone should. He had sent an email asking are there other alternatives like a lower dose. Apparently, he is the only guy complained about this, it's not offered to ease symptoms for anyone. patient declines a transfer to agent, he doesn't think it's an allergic reaction or anything like that, just a progression of severity is his main concern and he is weighing about other options. Will contact his healthcare provider. Patient described that he had a diastolic, heart condition. He wanted to know if any of the side effects of Paxlovid could affect his heart. He didn't mention that he was sick from COVID or was prescribed this medication.