Blood drawn and my numbers dropped quite a bit; platelets had come up a little bit; Very large black eye/Small black eye one time from rubbing my eye to hard; Diarrhoea/having bouts of diarrhoea/Diarrhoea seems to be getting better; Absolute neutrophils had dropped; Mouth sores/Had a peak of mouth sores; Cold sore in my mouth; Bruise really bad/bruise on my hands and arms all the time; This spontaneous case was reported by a physician and describes the occurrence of FULL BLOOD COUNT DECREASED (Blood drawn and my numbers dropped quite a bit), PLATELET COUNT INCREASED (platelets had come up a little bit), EYE CONTUSION (Very large black eye/Small black eye one time from rubbing my eye to hard), DIARRHOEA (Diarrhoea/having bouts of diarrhoea/Diarrhoea seems to be getting better) and CONTUSION (Bruise really bad/bruise on my hands and arms all the time) in a 70-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.    Co-suspect product included non-company product RUXOLITINIB PHOSPHATE (JAKAFI) for Polycythemia vera and Myelofibrosis.    Concurrent medical conditions included Appetite decreased NOS and Weight loss. Concomitant products included CITALOPRAM HYDROBROMIDE (CELEXA [CITALOPRAM HYDROBROMIDE]), FOLIC ACID, VITAMIN B COMPLEX, PARACETAMOL (TYLENOL EXTRA STRENGTH), PROBIOTICS NOS, LOVASTATIN and ACYCLOVIR [ACICLOVIR] for an unknown indication.   On 24-Sep-2019, the patient RUXOLITINIB PHOSPHATE (JAKAFI) (Oral) dosage was changed to dosage form twice a day. On 02-Feb-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 02-Mar-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On an unknown date, the patient started RUXOLITINIB PHOSPHATE (JAKAFI) (Oral) at an unspecified dose twice a day. On an unknown date, RUXOLITINIB PHOSPHATE (JAKAFI) (Oral) dosage was changed to at an unspecified dose twice a day and RUXOLITINIB PHOSPHATE (JAKAFI) (Oral) dosage was changed to at an unspecified dose twice a day. On 15-Mar-2021, the patient experienced CONTUSION (Bruise really bad/bruise on my hands and arms all the time). On an unknown date, the patient experienced FULL BLOOD COUNT DECREASED (Blood drawn and my numbers dropped quite a bit), PLATELET COUNT INCREASED (platelets had come up a little bit), EYE CONTUSION (Very large black eye/Small black eye one time from rubbing my eye to hard), DIARRHOEA (Diarrhoea/having bouts of diarrhoea/Diarrhoea seems to be getting better), NEUTROPHIL COUNT DECREASED (Absolute neutrophils had dropped), STOMATITIS (Mouth sores/Had a peak of mouth sores) and ORAL HERPES (Cold sore in my mouth). At the time of the report, FULL BLOOD COUNT DECREASED (Blood drawn and my numbers dropped quite a bit), PLATELET COUNT INCREASED (platelets had come up a little bit), CONTUSION (Bruise really bad/bruise on my hands and arms all the time), NEUTROPHIL COUNT DECREASED (Absolute neutrophils had dropped), STOMATITIS (Mouth sores/Had a peak of mouth sores) and ORAL HERPES (Cold sore in my mouth) outcome was unknown and EYE CONTUSION (Very large black eye/Small black eye one time from rubbing my eye to hard) and DIARRHOEA (Diarrhoea/having bouts of diarrhoea/Diarrhoea seems to be getting better) was resolving.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On 04-Feb-2021, Full blood count: decreased (Low) numbers dropped a quite bit. In March 2021, Full blood count: decreased (Low) platelets had come up a little bit and decreased (Low) absolute neutrophils had dropped.     For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown), the reporter did not provide any causality assessments.   Treatment information was not provided.  The patient received both scheduled doses of mRNA-1273 prior to the events therefore, action taken with the drug in response to the event is not applicable.  On an specified date, before starting Jakafi. On 24sep2019, the patient gained 3.2 lbs. Patient experienced diarrhea for the past two days. In sep 2019, reported as after starting Jakafi, the patient started developing mouth sores. Patient physician prescribed acyclovir, mouth sores had gone away, and she had not any new occurrences of mouth sores. Patient was doing well on Jakafi and her weight had increased from 123 pounds to 130 pounds. Patient got bruised really bad. On 17oct2020, the patient experienced cold sore in her mouth. Patient took acyclovir 800mg tablets as treatment Nov 20 patient had peak of mouth sores this month- she normally taken 1 tablet of 800 mg of acyclovir but doctor prescribed acyclovir 3 times a day during one week.    This case was linked to US-MODERNATX, INC.-MOD-2021-093619 (E2B Linked Report).   Most recent FOLLOW-UP information incorporated above includes: On 28-May-2021: Follow-up information received on 28-May-2021 contains no new information.; Sender's Comments:  US-MODERNATX, INC.-MOD-2021-093619:2 d dose