he experienced an allergic reaction; He felt some tingling in both his arms, between his hands and his elbows in both arms; It was a funny feeling like something was running through his arms or veins; he had a knot on his left arm; blood pressure was high, like 174 over whatever; chest pain; difficulty breathing; felt hot like he had a fever/Felt like there was fire on the inside; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP) from medical information team. The reporter is the patient.  A 60-year-old male patient received BNT162b2 (BNT162B2), as dose 4 (booster), single (Batch/Lot number: unknown) at the age of 60 years, in left arm for covid-19 immunisation. The patient had no relevant medical history. There were no concomitant medications. Vaccination history included: Bnt162b2 (dose:1, Lot number: unknown), for COVID-19 Immunization, reaction(s): "No adverse effect"; Bnt162b2 (dose:2, Lot number: unknown), for COVID-19 Immunization, reaction(s): "No adverse effect"; Bnt162b2 (dose:3, Lot number: unknown), administration date: 2021, for COVID-19 Immunization, reaction(s): "No adverse effect". The following information was reported: HYPERSENSITIVITY (non-serious), 4 days after the suspect product(s) administration, outcome "unknown", described as "he experienced an allergic reaction"; PARAESTHESIA (non-serious), outcome "unknown", described as "He felt some tingling in both his arms, between his hands and his elbows in both arms"; FEELING ABNORMAL (non-serious), outcome "unknown", described as "It was a funny feeling like something was running through his arms or veins"; NODULE (non-serious), outcome "not recovered", described as "he had a knot on his left arm"; HYPERTENSION (non-serious), outcome "unknown", described as "blood pressure was high, like 174 over whatever"; CHEST PAIN (non-serious), outcome "unknown"; DYSPNOEA (non-serious), outcome "unknown", described as "difficulty breathing"; FEELING HOT (non-serious), outcome "unknown", described as "felt hot like he had a fever/Felt like there was fire on the inside". The events "he experienced an allergic reaction", "he felt some tingling in both his arms, between his hands and his elbows in both arms", "it was a funny feeling like something was running through his arms or veins", "he had a knot on his left arm", "blood pressure was high, like 174 over whatever", "chest pain", "difficulty breathing" and "felt hot like he had a fever/felt like there was fire on the inside" required emergency room visit. Relevant laboratory tests and procedures are available in the appropriate section.  Additional information: Patient had no vaccinations (within 4 weeks) prior to the first administration date of the suspect vaccine. Patient had no adverse events following prior vaccinations. Patient had no family medical history relevant to AE(s). Patient received the first booster in Oct2021 or Nov2021 and received the 4th dose in Mar2021 or Apr2022. Caller stated he experienced an allergic reaction to the second booster dose of the Pfizer BioNTech COVID-19 Vaccine (Expiry date: unknown). Caller stated he went to the ER. Allergic reaction started probably 4 days after he got the shot. He felt some tingling in both his arms, between his hands and his elbows in both arms. He cant explain it. It was a funny feeling like something was running through his arms or veins. The next day he looked, and he had a knot on his left arm. He didn't pay it any mind, but the following Sunday, he went to the emergency room because his blood pressure was high, like 174 over whatever. Reporter stated he needs to see a dermatologist and get a biopsy. He was also having chest pain and difficulty breathing which is why he went to the emergency room. When they rolled up his sleeve at the emergency room to do the bloodwork, the doctor saw the knot and recommended the biopsy. Caller was sent home from the emergency room. The knot on his arm was just there. Its about the size of a 50 cent piece. Caller stated his vaccination card is at his house and does not have the vaccine information on him. Reporter stated that this was something totally different. It was shooting from his hands up to his elbows in both arms at the same time. Felt like there was fire on the inside. Every time it happened he felt hot like he had a fever. He had to get a cold glass of water. Then, the next morning in the shower, he saw the knot on his arm. Patient received no additional vaccines administered on same date as of the Pfizer Suspect. Events did not require physician office visit. Patient had an appointment with the dermatologist scheduled. Patient stated the lot from his second booster COVID-19 vaccine might be bad or tainted due to the allergic reaction he experienced and it may need to be pulled. Blood work, x-rays, EKG and tests were done while he was in the emergency room.  The information on the batch/lot number for BNT162b2 has been requested and will be submitted if and when received.