missed her period for 10 months; hard to breathe; Lack of drug effect; COVID-19; had 2 breakthrough cases of covid; too sick but it wasn't that bad; This spontaneous case was reported by a consumer and describes the occurrence of COVID-19 (had 2 breakthrough cases of covid), ILLNESS (too sick but it wasn't that bad), MENSTRUATION DELAYED (missed her period for 10 months), DYSPNOEA (hard to breathe) and DRUG INEFFECTIVE (Lack of drug effect) in a 20-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 001C21A and 039A21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     The patient's past medical history included COVID-19 on 14-Jan-2021. Concurrent medical conditions included Asthma (She had allergy asthma before she got COVID the first time and it turned into persistent asthma).   On 27-Mar-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 24-Apr-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. In 2021, the patient experienced COVID-19 (had 2 breakthrough cases of covid) and ILLNESS (too sick but it wasn't that bad). On 14-Jan-2022, the patient experienced COVID-19 (COVID-19). On an unknown date, the patient experienced MENSTRUATION DELAYED (missed her period for 10 months), DYSPNOEA (hard to breathe) and DRUG INEFFECTIVE (Lack of drug effect). The patient was treated with DOXYCYCLINE at an unspecified dose and frequency. At the time of the report, COVID-19 (had 2 breakthrough cases of covid), ILLNESS (too sick but it wasn't that bad), MENSTRUATION DELAYED (missed her period for 10 months), DYSPNOEA (hard to breathe), DRUG INEFFECTIVE (Lack of drug effect) and COVID-19 (COVID-19) outcome was unknown.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On 14-Jan-2021, SARS-CoV-2 test: positive (Positive) She had COVID for the first time. In August 2021, SARS-CoV-2 test: positive (Positive) second time having COVID and negative (Negative) Negative. On 14-Jan-2022, SARS-CoV-2 test: positive (Positive) Third time having COVID. On an unknown date, Pregnancy test: negative (Negative) Negative.         No concomitant medication were reported.   The first breakthrough case (second time having covid) was in August 2021, that time she tested negative the first time and they did not want to test her again but everyone in her family had it and she did a rapid test and was positive. She was too sick but it wasn't that bad, the first day was really bad but then not that bad. She was out of work for 10 days.  She was supposed to have her period right after getting the first dose of the vaccine but she missed it for 10 months, she just got her period back 2 months ago  Company Comment: This case refers to a 20-year-old female patient with a medical history of COVID-19  who experienced the unexpected event of COVID-19 at an unspecified date after receiving the second dose of mRNA-1273 vaccine while the second episode of COVID-19 occurred approximately 8 months after receiving the vaccine. No causality assessment was provided by the reporter. The benefit-risk relationship of mRNA-1273 is not affected by this report.   Most recent FOLLOW-UP information incorporated above includes: On 14-Jan-2022: Follow up contain no new information.; Sender's Comments: This case refers to a 20-year-old female patient with a medical history of COVID-19  who experienced the unexpected event of COVID-19 at an unspecified date after receiving the second dose of mRNA-1273 vaccine while the second episode of COVID-19 occurred approximately 8 months after receiving the vaccine. No causality assessment was provided by the reporter. The benefit-risk relationship of mRNA-1273 is not affected by this report.