Very sick the next day; very cold/Freezing cold/Weird cold/quivering cold/she was extremely cold with quivering/could not get warm; pain in her hands/pain in hands are still sore/the pain was so bad, still sore.; could not make a fist; She reports she could barely pick up a TV remote and her phone, it hurts to pick it up like it was too heavy; knee pain/her knee got worse/joints were in so much pain could barely touch her skin; started throwing up; This spontaneous case was reported by a patient and describes the occurrence of ILLNESS (Very sick the next day), FEELING COLD (very cold/Freezing cold/Weird cold/quivering cold/she was extremely cold with quivering/could not get warm), PAIN IN EXTREMITY (pain in her hands/pain in hands are still sore/the pain was so bad, still sore.), MOBILITY DECREASED (could not make a fist) and LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (She reports she could barely pick up a TV remote and her phone, it hurts to pick it up like it was too heavy) in a 65-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     Previously administered products included for Drug use for unknown indication: COVID-19 vaccines were Pfizer and COVID-19 vaccines were Pfizer. Past adverse reactions to the above products included No adverse event with COVID-19 vaccines were Pfizer and COVID-19 vaccines were Pfizer.    On 19-Apr-2022, the patient received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 20-Apr-2022, the patient experienced ILLNESS (Very sick the next day), FEELING COLD (very cold/Freezing cold/Weird cold/quivering cold/she was extremely cold with quivering/could not get warm), PAIN IN EXTREMITY (pain in her hands/pain in hands are still sore/the pain was so bad, still sore.), MOBILITY DECREASED (could not make a fist), LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (She reports she could barely pick up a TV remote and her phone, it hurts to pick it up like it was too heavy), ARTHRALGIA (knee pain/her knee got worse/joints were in so much pain could barely touch her skin) and VOMITING (started throwing up). At the time of the report, ILLNESS (Very sick the next day), FEELING COLD (very cold/Freezing cold/Weird cold/quivering cold/she was extremely cold with quivering/could not get warm), PAIN IN EXTREMITY (pain in her hands/pain in hands are still sore/the pain was so bad, still sore.), MOBILITY DECREASED (could not make a fist), LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (She reports she could barely pick up a TV remote and her phone, it hurts to pick it up like it was too heavy) and ARTHRALGIA (knee pain/her knee got worse/joints were in so much pain could barely touch her skin) had not resolved and VOMITING (started throwing up) had resolved.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On an unknown date, X-ray: result not reported Result not reported.         Patient reported that she was on a lot of medications, but did not specify about it.  Patient was administered with Moderna COVID-19 booster dose.  The patient was very sick the very next day. Patient was was very cold, experienced this for several months. The patient was freezing cold, like really cold, like a weird cold and could not get warm. That evening, the patient could not get warm to save her life, was quivering cold. Patient started throwing up and reports pain in her hands and knees. The patient could not make a fist. Patient's cold continued, she reports pain in the knee. Then, the cold was gone, but the pain in the hands are still sore. The soreness in hand persisted and knee got worse. This happened 3 times, and the patient  was extremely cold with quivering, sick again where joints were in so much pain that could barely touch the skin, but no throwing up the other times. The patient could barely pick up a TV remote and phone, it hurts to pick it up like it was too heavy, the pain was so bad, still sore. The patient was getting x rays, it has been a month and not happy about it. The third time it happened on 20 May 2022. In one month, it happened 3 times between 20 Apr 2022 and 20 May 2022. She is still experiencing symptoms.  No treatment information was reported.