Creutzfeldt-Jakob Disease ,fatal degenerative brain disorder , and her brain degenerated until she passed away on Aug. 2, 2021; This spontaneous case was reported by a consumer and describes the occurrence of CREUTZFELDT-JAKOB DISEASE (Creutzfeldt-Jakob Disease ,fatal degenerative brain disorder , and her brain degenerated until she passed away on Aug. 2, 2021) in a 70-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination.     No Medical History information was reported.   On 16-Feb-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 17-Mar-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On an unknown date, the patient experienced CREUTZFELDT-JAKOB DISEASE (Creutzfeldt-Jakob Disease ,fatal degenerative brain disorder , and her brain degenerated until she passed away on Aug. 2, 2021) (seriousness criteria death, disability and medically significant). The patient died on 02-Aug-2021. The reported cause of death was creutzfeldt-jakob disease ,fatal degenerative brain disorder , and her brain degenerated until she passed away on aug. 2, 2021. It is unknown if an autopsy was performed.            No concomitant medications reported by reporter. After Moderna vaccination patient felt different and patient developed the symptoms of sporadic Creutzfeldt-Jakob Disease (CJD) included that the Patient developed numbness that spread throughout the entire left side of her body, blindness and hearing loss. Patient lost the ability to walk and communicate, and her brain degenerated until she passed away on 02-Aug-2021. Patient was died just five months after receiving her second dose of Moderna. No treatment medications provided by the reporter.  Company Comment:  This spontaneous case concerns a 70-year-old female patient with no medical history reported, who experienced the unexpected serious event of Creutzfeldt-Jakob Disease, that occurred on an unknown date after receiving the second dose of mRNA-1273 vaccine (latency between vaccine and event cannot be established), that led to the eventual demise of the patient and assessed as disabling and medically significant.  Patient developed numbness that spread throughout the left side of the body and a clinical course of blindness, deafness, loss of ability to walk and communicate, and brain degeneration.  Patient reportedly died from the rapid and fatal degenerative brain disorder Creutzfeldt-Jakob Disease 4 months and 16 days post vaccination. However, an autopsy report was not provided. Previously received first dose of COVID-19 vaccine was also mRNA-1273 vaccine (interval between two doses is 29 days). The benefit-risk relationship of mRNA-1273 Vaccine is not affected by this report.; Sender's Comments: This spontaneous case concerns a 70-year-old female patient with no medical history reported, who experienced the unexpected serious event of Creutzfeldt-Jakob Disease, that occurred on an unknown date after receiving the second dose of mRNA-1273 vaccine (latency between vaccine and event cannot be established), that led to the eventual demise of the patient and assessed as disabling and medically significant.  Patient developed numbness that spread throughout the left side of the body and a clinical course of blindness, deafness, loss of ability to walk and communicate, and brain degeneration.  Patient reportedly died from the rapid and fatal degenerative brain disorder Creutzfeldt-Jakob Disease 4 months and 16 days post vaccination. However, an autopsy report was not provided. Previously received first dose of COVID-19 vaccine was also mRNA-1273 vaccine (interval between two doses is 29 days). The benefit-risk relationship of mRNA-1273 Vaccine is not affected by this report.; Reported Cause(s) of Death: Creutzfeldt-Jakob Disease ,fatal degenerative brain disorder , and her brain degenerated until she passed away on Aug. 2, 2021