hot flushes; sweating; chills; a cycle of hot and cold; insomnia; lack of appetite; She doesn't have a fever, she takes her temperature, but her core body temperature feels like she has got a furnace inside her; She burns and burns, it is hot hot hot; She feels depressed and hopeless; diarrhea; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP) from medical information team. The reporter is the patient.  A 73-year-old female patient received BNT162b2 (BNT162B2), on 03Apr2021 as dose 1, single (Lot number: EW0151) at the age of 73 years, in left arm for covid-19 immunisation. The patient had no relevant medical history. The patient took concomitant medications. The following information was reported: DIARRHOEA (non-serious) with onset 04Apr2021, outcome "not recovered", described as "diarrhea"; HOT FLUSH (non-serious), outcome "unknown", described as "hot flushes"; HYPERHIDROSIS (non-serious), outcome "unknown", described as "sweating"; CHILLS (non-serious), outcome "unknown"; FEELING OF BODY TEMPERATURE CHANGE (non-serious), outcome "unknown", described as "a cycle of hot and cold"; INSOMNIA (non-serious), outcome "unknown"; DECREASED APPETITE (non-serious), outcome "unknown", described as "lack of appetite"; BODY TEMPERATURE ABNORMAL (non-serious), outcome "unknown", described as "She doesn't have a fever, she takes her temperature, but her core body temperature feels like she has got a furnace inside her"; BURNING SENSATION (non-serious), outcome "unknown", described as "She burns and burns, it is hot hot hot"; DEPRESSION (non-serious), outcome "unknown", described as "She feels depressed and hopeless". Relevant laboratory tests and procedures are available in the appropriate section. Therapeutic measures were taken as a result of diarrhoea. Additional information: Caller reports that she has been experiencing diarrhea since she first got the Pfizer covid 19 vaccine. She would like to know if this has already been reported as a side effect before and wanted information and how to treat it. She asks for information on any ongoing research on how to treat it. She also reports having hot flushes, sweating, chills, a cycle of hot and cold, insomnia, and lack of appetite. She is also aware that diarrhea, fever, and chills are among the most reported side effects from the vaccine so she is assuming there must be something that Pfizer is doing to try and prevent or treat the diarrhea. She mentions that her diarrhea is relieved by Imodium but she asks if there was any other medication she could try to treat her diarrhea, she also asks if we had information on how other patients treat their diarrhea and if other patients have reported it before. Outcome of Diarrhea at the time of last observation was Not recovered. Serious was reported as No. Consumer further calling about Pfizer COVID-19 vaccines and boosters. The next day after her first vaccine she had diarrhea which she thought was from her other medication. The following month she got another dose of the vaccine, and then she got two boosters. She has been dealing with constant diarrhea, hot flashes, or chills. Weight was 135-140 lbs. Pfizer COVID-19 vaccine: She doesn't remember which cap color she got, it might have been purple, but she doesn't know. Her vaccine card is handwritten and doesn't have NDC/EXP for any of her doses, only manufacturer and LOT. Her first dose was given 03Apr2021 and has a little sticker that provides LOT: EW0151. Her diarrhea started after her first dose, then it stopped and she connected it to her antidepressant medication that she stopped and the diarrhea stopped when she stopped that medication. No further details provided about caller's antidepressant medication. Her diarrhea was constant for about two months after her first vaccine. She feels like she is dying, she is desperate to find out what is going on with her and find out how to get it to stop. She has chills and hot flashes and sweating along with diarrhea, a combination of symptoms, that are relentless. She feels like she is melting from the inside out. She doesn't have a fever, she takes her temperature, but her core body temperature feels like she has got a furnace inside her. She burns and burns, it is hot hot hot, so she stops and lays down in front of the AC then she gets cold and covers up because she is feeling chilly. After a certain length of time she overheats. She clarifies her phrase about feeling like she is dying by saying that she feels like she wants to die because she wants it to stop. She feels depressed and hopeless, it affects her in a lot of ways, physically and emotionally. She has been taking Imodium to stop the diarrhea. She has trouble sleeping because it wakes her up at night. She has been taking Imodium and Pepto-Bismol liquid capsules to treat the diarrhea. The Imodium she takes every twelve hours, one capsule, active ingredient Loperamide HCl 2mg. She says her glasses and her eyes are getting, she is crying too now so maybe. Imodium date she started taking unknown, the Pepto-Bismol she started in May2021 or Jun2021, and is sporadically taking Bismuth subsalicylate 262mg, which she takes maybe every 8 hours. She says she needs a magnifying glass to make it bigger for the Bismuth label to read the word subsalicylate, then clarifies that needing a magnifying glass to read labels is normal for her lately.; Sender's Comments: Linked Report(s) : US-PFIZER INC-202201174373 same patient/reporter; different vaccine dose/AE;US-PFIZER INC-202201174372 same patient/reporter; different vaccine dose/AE;US-PFIZER INC-2021581190 same patient/reporter; different vaccine dose/AE;