had an incredible positive reaction to the Pfizer Covid vaccine; after first dose of the vaccine, her voice was very close to her old voice; had a much easier time swallowing her food; She was able to walk easily without any assistance; energy level was greatly improved; This is a spontaneous report from a contactable consumer. This is one of the two reports. This case is for first dose. A female patient of an unspecified age received BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE; Solution for injection; Lot Number and Expiration date was not reported), first dose via an unspecified route of administration on an unspecified date as DOSE 1, SINGLE for covid-19 immunisation. Medical history included amyotrophic lateral sclerosis (ALS) from Apr2021 to an unknown date, has had problems with her voice, swallowing, has had muscle tremors, had a lot of headaches, gets tired very quickly, experienced as her head being in a fog every day, recently started walking with a cane due to issues with her left foot and leg from an unknown date and unknown if ongoing. The patient's concomitant medications were not reported. The patient experienced or had an incredible positive reaction to the Pfizer covid vaccine, after first dose of the vaccine, her voice was very close to her old voice; had a much easier time swallowing her food; she was able to walk easily without any assistance, energy level was greatly improved on unspecified date in 2021. This report was not related to a study or programme. Caller was a Pfizer employee, with unknown territory, IT department. Stated he got someone who was third party, who was a friend of a friend who sent him an email just a half hour ago on 03Sep2021 about the impact the Pfizer Covid vaccine had on an ALS patient. Provided patient details, unable to provide address details. Mentioned that Pfizer may contact them for further questions, but she may have trouble talking so Pfizer may speak with her boyfriend, since he may be able to answer questions for her. No further details provided. Caller unable to provide patient's date of birth, age of onset, height, weight, ethnicity, or primary care provider details. Caller proceeded to provide details from email, stating the emailer did mention Covid: "I am writing this on behalf of my girlfriend who had an incredible positive reaction to the Pfizer Covid vaccine. She was recently diagnosed with ALS in April: has had problems with her voice, swallowing, recently started walking with a cane due to issues with her left foot and leg. Has had muscle tremors throughout her body and gets tired very quickly. Has lot of headaches and experienced as her head being in a fog every day. After her first dose of the vaccine, her voice was very close to her old voice. She was talking every very little effort and had a much easier time swallowing her food. She was able to walk easily without any assistance and was even able to bend and touch the floor, which was increased since she couldn't get off the couch with a little help, days prior to getting the vaccine. Her energy level was greatly improved, but unfortunately this only lasted 2 1/2 days. She was scheduled to go on 28Sep2021 for a clinical trial, where they will also tell the doctors about this." Caller states this was the end of the email received today and he was unable to provide outcome of events stating he did not know person/patient and other dates were not provided. No further details provided. Unable to provide date, NDC, Lot, dose, or expiry for first Covid vaccine dose, it was not specified in email. Caller unable to provide if any other vaccines given the same day or any problems with vaccines in past. Unable to provide the facility in which vaccines were given. No further details provided. Clinical outcome of events was recovered on unspecified date in 2021.  Information about lot/batch number will be obtained during follow-up.