cough; Not feeling well; Injection site hurt; high fever, above 103°F/ her fever went to 103.6°F, 103.7°F and 103.3°F; feeling worse or a cold; feeling worse or a cold; congestion; body aches; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP) from medical information team. The reporter is the patient.  A 46-year-old female patient received pneumococcal 20-val conj vac (dipht CRM197 protein) (PREVNAR 20), on 11May2023 as dose number unknown, 0.5ml single (Batch/Lot number: unknown) at the age of 46 years, in left arm for immunisation. The patient's relevant medical history included: "Asthma" (ongoing). The patient's concomitant medications were not reported. The following information was reported: VACCINATION SITE PAIN (non-serious) with onset 11May2023, outcome "recovered" (16May2023), described as "Injection site hurt"; MALAISE (non-serious) with onset 12May2023, outcome "not recovered", described as "Not feeling well"; PAIN (non-serious) with onset May2023, outcome "unknown", described as "body aches"; NASAL CONGESTION (non-serious) with onset May2023, outcome "unknown", described as "congestion"; FEELING ABNORMAL (non-serious), FEELING COLD (non-serious) all with onset May2023, outcome "unknown" and all described as "feeling worse or a cold"; PYREXIA (non-serious) with onset May2023, outcome "not recovered", described as "high fever, above 103°F/ her fever went to 103.6°F, 103.7°F and 103.3°F"; COUGH (non-serious), outcome "unknown". The events "high fever, above 103°f/ her fever went to 103.6°f, 103.7°f and 103.3°f", "feeling worse or a cold", "congestion", "body aches", "cough", "injection site hurt" and "not feeling well" required emergency room visit. Relevant laboratory tests and procedures are available in the appropriate section. Therapeutic measures were taken as a result of pyrexia.  Additional information: The caller (patient) reported the side effects she was having was something other guys were seeing happen. It is miserable, costing her big time, and was just awful. The HCP administered Prevnar 20 to the caller at the left upper arm area on 11May2023. She was completely healthy the day received Prevnar 20 and got progressively worse from Prevnar 20. On 11May2023, the caller's injection site hurt. didn't know if chalked up to that hurting but by the 12May2012 was not feeling well. The not feeling well was persisting. Caller got worse all through Sunday (13May2023), feeling really horrible and then it continued to get bad and stay bad. Ended up in the emergency room on 16May2023. Went to the urgent care first and was tested to see if Covid or Flu or anything else and all of those tests were negative. Caller then sent to emergency room but they said the patient was not small enough to be handle at the urgent care. The emergency room also did a bunch of tests and concluded, the caller had a bad reaction to the Prevnar 20 Vaccine. Clarified was discharged from the emergency room after a few hours. She was not just feeling worse or a cold, she had body aches, high fever, above 103 degree F (her fever went to 103.6 degreeF, 103.7 degreeF and 103.3 degree) consistently for days, fever was 103.6 and wasn't coming down. Fever was staying high. Fever only came down with ibuprofen. Cough, a degree of congestion, maybe because of the other symptoms that her system was weaken overall. She couldn't function, could not take care of children or drive, she could not go to work and lost pay for the whole week and she had to pay for urgent care and the emergency room, all because she went for a physical and her doctor recommended Prevnar 20 vaccine. Blood work was done and blood work was clear. Chest x-ray was clear, done at hospital. Blood work and everything else did not show anything. Injection site hurt finally went away on Tuesday (16May2023).   The information on the batch/lot number for pneumococcal 20-val conj vac (dipht CRM197 protein) has been requested and will be submitted if and when received.