Patient suffered an immediate anaphylactic shock reaction with a large hives, A large rash and swelling around the injection site; Pain; Patient suffered an immediate anaphylactic shock reaction with a large hives, A large rash and swelling around the injection site; Patient suffered an immediate anaphylactic shock reaction with a large hives, A large rash and swelling around the injection site; Patient suffered an immediate anaphylactic shock reaction with a large hives, A large rash and swelling around the injection site; Within a day patient began to experience muscular weakness, crushing chest pressure and pain, coughing; unable to walk, operate a vehicle; Within a day patient began to experience muscular weakness, crushing chest pressure and pain, coughing; Within a day patient began to experience muscular weakness, crushing chest pressure and pain, coughing; coughing; complete intolerance to heat (wasn't able to breathe in normal temperature places); irregular heartbeat and heart rate; sinus arrhythmia; left atrial enlargement; became completely weak; couldn't perform every day regular tasks; skin was pale; complete intolerance to heat; right ventricular conduction delay; I got large dark circles under my eyes; muscle tone was so weak that it caused nerves and disc problems in my back leading me to severe pain; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP). The reporter is the patient.  A 41-year-old female patient (not pregnant) received BNT162b2 (BNT162B2), on 21Jan2022 at 04:15 as dose 1, single (Lot number: FJ1614) at the age of 41 years, in left arm for covid-19 immunisation. The patient's relevant medical history included: "Allergies" (unspecified if ongoing); "COVID-19" (unspecified if ongoing), notes: If Covid prior vaccination: Yes. There were no concomitant medications. No other vaccine in Four weeks. No other medication in two weeks. The following information was reported: DARK CIRCLES UNDER EYES (disability, life threatening) with onset 21Jan2022 at 21:00, outcome "not recovered", described as "I got large dark circles under my eyes"; PAIN (disability, life threatening) with onset 21Jan2022 at 21:00, outcome "not recovered"; ANAPHYLACTIC SHOCK (disability, medically significant, life threatening), URTICARIA (disability, life threatening), RASH (disability, life threatening), VACCINATION SITE SWELLING (disability, life threatening) all with onset 21Jan2022 at 21:00, outcome "not recovered" and all described as "Patient suffered an immediate anaphylactic shock reaction with a large hives, A large rash and swelling around the injection site"; MUSCULAR WEAKNESS (disability, life threatening), CHEST DISCOMFORT (disability, life threatening), CHEST PAIN (disability, life threatening) all with onset 21Jan2022 at 21:00, outcome "not recovered" and all described as "Within a day patient began to experience muscular weakness, crushing chest pressure and pain, coughing"; ASTHENIA (disability, life threatening) with onset 21Jan2022 at 21:00, outcome "not recovered", described as "became completely weak"; TEMPERATURE INTOLERANCE (disability, life threatening) with onset 21Jan2022 at 21:00, outcome "not recovered", described as "complete intolerance to heat"; DYSPNOEA (disability, life threatening) with onset 21Jan2022 at 21:00, outcome "not recovered", described as "complete intolerance to heat (wasn't able to breathe in normal temperature places)"; COUGH (disability, life threatening) with onset 21Jan2022 at 21:00, outcome "not recovered", described as "coughing"; LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (disability, life threatening) with onset 21Jan2022 at 21:00, outcome "not recovered", described as "couldn't perform every day regular tasks"; HEART RATE ABNORMAL (disability, life threatening) with onset 21Jan2022 at 21:00, outcome "not recovered", described as "irregular heartbeat and heart rate"; LEFT ATRIAL ENLARGEMENT (disability, life threatening) with onset 21Jan2022 at 21:00, outcome "not recovered"; INTERVERTEBRAL DISC DISORDER (disability, life threatening) with onset 21Jan2022 at 21:00, outcome "not recovered", described as "muscle tone was so weak that it caused nerves and disc problems in my back leading me to severe pain"; DEFECT CONDUCTION INTRAVENTRICULAR (disability, life threatening) with onset 21Jan2022 at 21:00, outcome "not recovered", described as "right ventricular conduction delay"; SINUS ARRHYTHMIA (disability, life threatening) with onset 21Jan2022 at 21:00, outcome "not recovered"; PALLOR (disability, life threatening) with onset 21Jan2022 at 21:00, outcome "not recovered", described as "skin was pale"; GAIT DISTURBANCE (disability, life threatening) with onset 21Jan2022 at 21:00, outcome "not recovered", described as "unable to walk, operate a vehicle". The events "patient suffered an immediate anaphylactic shock reaction with a large hives, a large rash and swelling around the injection site", "pain", "within a day patient began to experience muscular weakness, crushing chest pressure and pain, coughing", "unable to walk, operate a vehicle", "coughing", "complete intolerance to heat (wasn't able to breathe in normal temperature places)", "irregular heartbeat and heart rate", "sinus arrhythmia", "left atrial enlargement", "became completely weak", "couldn't perform every day regular tasks", "skin was pale", "complete intolerance to heat", "right ventricular conduction delay", "i got large dark circles under my eyes" and "muscle tone was so weak that it caused nerves and disc problems in my back leading me to severe pain" required physician office visit. The patient underwent the following laboratory tests and procedures: Electrocardiogram: (unspecified date) EKG showed sinus, notes: my EKG showed sinus, arrhythmia, left atrial enlargement, right ventricular conduction delay; Magnetic resonance imaging heart: (unspecified date) Unknown result; SARS-CoV-2 test: (24Jan2022) Negative, notes: Other; X-ray: (unspecified date) Unknown result. Therapeutic measures were taken as a result of anaphylactic shock, pain, urticaria, rash, vaccination site swelling, muscular weakness, gait disturbance, chest discomfort, chest pain, cough, dyspnoea, heart rate abnormal, sinus arrhythmia, left atrial enlargement, asthenia, loss of personal independence in daily activities, pallor, temperature intolerance, defect conduction intraventricular, dark circles under eyes, intervertebral disc disorder which included anti-tussive Rx NSAID, EKG chest x-ray, cardiac MRI. Clinical course: Patient suffered an immediate anaphylactic shock reaction with a large hives, A large rash and swelling around the injection site. Within a day patient began to experience muscular weakness, crushing chest pressure and pain, coughing, (like possible pericarditis myocarditis or pleurisy) followed by prolonged immune over activation and muscle weakness, complete intolerance to heat (wasn't able to breathe in normal temperature places), and irregular heartbeat and heart rate and EKG showed sinus arrhythmia, left atrial enlargement, right ventricular conduction delay. Patient became completely weak and couldn't perform every day regular tasks. Patient's skin was pale. Patient got large dark circles under eyes and was unable to walk, operate a vehicle, or perform really necessary chores. For the next few months patient's muscle tone was so weak that it caused nerves and disc problems in back leading to severe pain and being unable to walk for several weeks and perform everyday tasks. AE resulted in doctor or other healthcare professional office/clinic visit, Life threatening illness (immediate risk of death from the event), Disability or permanent damage. Patient was tested for COVID-19 post vaccination.  No follow-up attempts are possible. No further information is expected.