Doctors diagnosed her with ALS from the vaccine; She is 100% dependent upon my dad to help her complete daily activities including eating and drinking, personal hygiene, walking, etc; Coughing; Nasal congestion; A lot of Phlegm; Patient had respiratory symptoms; This spontaneous case was reported by a consumer and describes the occurrence of AMYOTROPHIC LATERAL SCLEROSIS (Doctors diagnosed her with ALS from the vaccine) and LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (She is 100% dependent upon my dad to help her complete daily activities including eating and drinking, personal hygiene, walking, etc) in a 62-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 031B21A and 026A21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below. No Medical History information was reported.On 19-Mar-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form.On 19-Apr-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 19-Apr-2021, the patient experienced AMYOTROPHIC LATERAL SCLEROSIS (Doctors diagnosed her with ALS from the vaccine) (seriousness criterion medically significant), LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (She is 100% dependent upon my dad to help her complete daily activities including eating and drinking, personal hygiene, walking, etc) (seriousness criteria disability and medically significant), COUGH (Coughing), NASAL CONGESTION (Nasal congestion), PRODUCTIVE COUGH (A lot of Phlegm) and RESPIRATORY SYMPTOM (Patient had respiratory symptoms). At the time of the report, AMYOTROPHIC LATERAL SCLEROSIS (Doctors diagnosed her with ALS from the vaccine) outcome was unknown and LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (She is 100% dependent upon my dad to help her complete daily activities including eating and drinking, personal hygiene, walking, etc), COUGH (Coughing), NASAL CONGESTION (Nasal congestion), PRODUCTIVE COUGH (A lot of Phlegm) and RESPIRATORY SYMPTOM (Patient had respiratory symptoms) had not resolved. No concomitant medication were reported.Patient has no prior medical history. Prior to the vaccine she was walking 5-6 miles a day, lifted weights, maintained a healthy diet, ran around with her grandchildren, enjoyed road trips in her jeep, and simply enjoyed every day life. All of which have been robbed from her in the days and weeks following her vaccination and have been told this is incurable and there is nothing to treat it. Company comment: This is a spontaneous case concerning a  62-year-old female patient with no prior medical history, who experienced serious, unexpected events of Amyotrophic Lateral Sclerosis and loss of personal independence in daily activities. On 19-Mar-2021 the patient received first dose of mRNA-1273 vaccine and experienced weakness in right arm. On 19-Apr-2021 she received second dose and immediately she began to experienced respiratory symptoms including coughing, nasal congestion, and phlegm. In addition she developed additional weakness in her right hand, which is no longer in use, and right leg. She had slurred speech and difficulty eating and was no longer able to walk independently. After further testing she was diagnosed with ALS stemming from the vaccine. Diagnostic test results were not provided. It was reported that patient is not taking any medications. The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report.This case was linked to MOD-2022-449266 (Patient Link). Most recent FOLLOW-UP information incorporated above includes:On 12-Jan-2022: Significant follow up received on 12-Jan-2022 new events Weakness has now progressed to her right leg and she is no longer able to walk independently, difficulty eating added.On 14-Jan-2022: Follow up received , Batch number added for both doses. Sender's Comments: This is a spontaneous case concerning a  62-year-old female patient with no prior medical history, who experienced serious,unexpected events of Amyotrophic Lateral Sclerosis and loss of personal independence in daily activities. On 19-Mar-2021 the patient received first dose of mRNA-1273 vaccine and experienced weakness in right arm. On 19-Apr-2021 she received second dose and immediately she began to experience respiratory symptoms including coughing, nasal congestion, and phlegm. In addition she developed additional weakness in her right hand and right leg. She had slurred speech and difficulty eating and was no longer able to walk independently. After further testing she was diagnosed with ALS stemming from the vaccine. Diagnostic test results were not provided. It was reported that patient is not taking any medications. The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report.