Fall/ The second fall put him back in the hospital; He had a fever of 104; Endocarditis; got sick; sepsis; stroke; fell and broke his hip; weak; get a partial hip replacement; enlarged heart; know which bacteria caused it; his blood sugar was in the 600s; sleeping all of the time; lost his appetite; could not get out of bed; Patient was not eating or drinking; This is a spontaneous report received from a Pfizer sponsored program. A 66-years-old male patient received first dose of BNT162B2 (PFIZER-BIONTECH COVID-19 mRNA VACCINE, Formulation: Solution for Injection, Batch/Lot number: EW0169) via an unspecified route of administration, administered in Arm on 14Apr2021 around 15:00 to 15:30 as dose 1, single for covid-19 immunisation. The patient's medical history included atrial fibrillation, patient was diagnosed years ago, before his stroke in 2015, a long time ago, cardiac failure congestive, aortic valve disease, cerebrovascular accident, diabetes mellitus, hypertension, last year patient had a blood infection, so he had to take four antibiotics. The patient's concomitant medications included rivaroxaban (XARELTO) taken for atrial fibrillation. It was reported that patient received the first dose of the vaccine in mid-April and got sick 2 days later(18Apr2021). Patient had a fever of 104. Caller took him to the doctor and patient was diagnosed sepsis. Patient was in the hospital and was then tested for and diagnosed with Endocarditis due to the sepsis. Patient was currently in a rehab facility and was weak. The rehab facility wanted to give patient the second dose of the covid vaccine. But the rehab facility was not sure if they will get the Pfizer covid vaccine. Reporter was worried about patient getting a second dose of anything. This was not the first-time patient has had endocarditis. Patient has been diagnosed with it before. Patient has a history of congestive heart failure, a bad aortic value, past stroke, and diabetes. They do not know if patient still had endocarditis, but patient has completed the antibiotics. They are unable to test patient again for endocarditis because he is in such bad shape. Patient had one side that was weak, and then he fell and broke his hip. Patient was not a candidate for open heart surgery because of his enlarged heart. Before patient received the first dose of the covid vaccine, patient was sleeping all the time and reporter thought it was due to the sepsis. The doctor told reporter that the sepsis was there before patient got the first dose of the covid vaccine. Patient has A-Fib and takes Eliquis. It was reported that patient had a stroke while he was in the hospital. Patient fell because of the weakness from his stroke. The second fall put him back in the hospital. Patient was in poor shape; his blood sugar was in the 600s. Before patient went to the hospital, he was sleeping all of the time, and he lost his appetite. They did not know if patient still has endocarditis because he could not have the follow up procedure done because he was in bad shape. Patient had weakness and fell and broke his hip. Patient was currently in rehab for physical therapy. Reporter clarifies that she took patient to the emergency room, and then he was admitted to the hospital. Patient's fever did not start out at 100 degrees, it gradually went up to 104 degrees. By the second or third day, patient's fever got up to 104 degrees. Reporter is back to square one for help. Reporter is asking if there is anyone who would know what to do. Patient's cardiologist said for patient to get the second dose of the covid vaccine. Reporter knows that no one had that in the clinical trial. Before the covid vaccine, patient was having a crown done in his mouth. Last year patient had a blood infection, so he had to take four antibiotics. Reporter thinks they were called amoxicillin, and they were 500mg each. Patient had to take them all at once as a preventive. Patient is on a lot of things, that reporter does not even know. Patient has had a lot of things done to his heart. Patient has had to have ablations. Patient has a very bad heart. Patient has a question about herself. She had the covid vaccine and had no reactions. She is on Celebrex 200mg. Reporter stopped taking a day and a half before the covid vaccine. Reporter is asking if she could have messed herself up by taking an anti-inflammatory, and if taking Celebrex could have prevented her from getting the full effect. Prior to taking Covid vaccine her husband has had Endocarditis, congestive heart failure, bad heart valve and a stroke. 1st dose of vaccine mid-April. 2 days later had a fever of 104 and was admitted to the hospital with sepsis. The sepsis caused endocarditis again. Husband is in rehab facility, and they want him to take a second dose. Should he be getting 2nd dose of Pfizer or a different Covid vaccine. Wife wondering if husband should get 2nd dose at all. Reporter does not think that this has anything to do with the covid vaccine, since they know which bacteria caused it. Reporter thinks that maybe patient getting the first dose of the covid vaccine put patient over the edge. This is the second time that patient has had vegetation, the first time was last year. Reporter thinks that all of patient's doctors are panicking over the covid vaccine. Reporter knows that patient is in bad shape. In the clinical trial, there was nothing in there about congestive heart failure, or nothing about endocarditis. Patient may still have endocarditis. Reporter does not know what will happen to patient if he gets the second dose of the covid vaccine. Reporter states that unfortunately patient does not go to the best cardiologist. Reporter thinks that patient is so bad off, that he could be on palliative care. The only reason reporter waited so long to call Pfizer is because patient is in rehab now, and they might be getting in the Pfizer covid vaccine. They asked reporter if she wanted patient to get the second dose of the Pfizer covid vaccine. They should get them in on 16Jul2021. Reporter said yes, about a week ago, but it has been on her mind to call and ask the source. Reporter took patient to the hospital, and the doctors diagnosed him with sepsis: Patient was not willing to go to the hospital at first. Patient could not get out of bed. Patient was not eating or drinking. Reporter was trying to give him stuff. Reporter is not a scientist. An infectious disease doctor told reporter that patient already had sepsis before the covid vaccine. Patient was in terrible shape. Patient had a stroke while he was in the hospital. They figured out he had a stroke about five days after being in the hospital. After the stroke, patient had two weeks of physical therapy there. Dates of Hospitalization: He was in the hospital for a few weeks. Patient was home for two days he fell because of the weakness from his stroke. The second fall put him back in the hospital. Patient had to get a partial hip replacement. For about a week now, patient has been in rehab. Patient has A-Fib, since the stroke, he is not on Eliquis. Patient was not on Eliquis before. Patient also has hypertension, but it is under control. Therapeutic measures were taken as a result of endocarditis and fell and broke his hip. The outcome of the events was unknown.