has terrible dermatitis in his hands, and after he took the Pfizer COVID-19 vaccine his dermatitis disappeared and his hands are perfect; This is a spontaneous report received from a contactable reporter (consumer). The reporter is the parent. A 53-year-old male patient received BNT162b2 (PFIZER BIONTECH COVID-19 VACCINE), in Nov2022 as dose 1, single (lot number unknown) at the age of 53 years, in arm for covid-19 immunisation. The patient's relevant medical history included: "asthma" (unspecified if ongoing), notes: diagnosed about 3-4 years old; "terrible dermatitis in hands" (ongoing), notes: symptoms: itching and scratching, rash; "terrible allergies" (unspecified if ongoing), notes: his whole life, most or all went away; "cold and it goes into his chest" (unspecified if ongoing), notes: uses an inhaler when he gets a chest cold; "cold" (unspecified if ongoing). Concomitant medication included: PRIMATENE MIST taken for nasopharyngitis, asthma, lower respiratory tract infection. The following information was reported: THERAPEUTIC RESPONSE UNEXPECTED (non-serious) with onset Nov2022, 6 days after the suspect product administration, outcome "unknown", described as "has terrible dermatitis in his hands, and after he took the Pfizer COVID-19 vaccine his dermatitis disappeared and his hands are perfect".  Additional Information: The patient's mother reported that the patient has terrible dermatitis in his hands, and after he took the Pfizer COVID-19 vaccine his dermatitis disappeared and his hands are perfect, so she wanted to report this to someone. The patient didn't want to get the COVID vaccine, then he got it in Nov2022. November, the patient was at the sink and he showed what his hands looked like, and the mother thought it was because he used to run hot water over his hands to help the itching and scratching. In fact, he was just washing his hands and showed the mother and said a week after the vaccine that is what his hands looked like, the rash was all gone, his hands looked like a baby's tushy. Six days after he got the COVID shot, his hands cleared up to look like the bottom of a two-year-old child and he doesn't take medication or use any ointments. A week after the "test" his hands were clear, clarified to vaccine, and she knows that the vaccine was the only thing that was different because he doesn't use any medications. The mother doesn't know if the patient got a second dose of the COVID vaccine. Now 2-3 months later he was due to get a booster. It's been two months or so, so he is supposed to go back for a booster. His hands are acting up again, he told her the other day that they are starting to itch a little bit. He has done no treatment, he won't treat it, he will let it get worse and worse and put his hands under hot water, and maybe get another booster COVID shot. The only thing the patient does take is Primatene Mist, which he started when he used to take prescription inhalers then started growing out of asthma in college she thinks. When he is sick with a cold, he uses the Primatene Mist that he gets over the counter, it is like an inhaler. As a young child he was very asthmatic, he didn't have reaction to anything, then over the years he outgrew the asthma and the only time he suffers is when he gets a cold and it goes into his chest, then he uses an inhaler when he gets a chest cold. He never had dermatitis until he was an adult and started in the food business. The dermatitis affected both hands from his wrist down, terrible dermatitis, he has to wear gloves. Nothing worked, he suffered because he likes his job, and he just comes home and ran his hands under hot water. The mother thought she should call and tell about this medical miracle, and find out if anyone else has reported this. There were no investigations. Anatomical vaccination site was either left or right arm. Indication for the vaccination was reported as "she insisted all her kids get it".  No follow-up attempts are possible; information about lot/batch number cannot be obtained. No further information is expected.