ANEURYSM IN RIGHT SIDE OF BRAIN; STROKE; ANXIETY; FATIGUE; This spontaneous report received from a patient concerned a 65-year-old white, not Hispanic or Latino Elderly female. The patient's height, and weight were not reported. The patient's past medical history included spinal fusion (Performed to fix the back 2 to 3 years ago), and concurrent conditions included non-smoker, and other pre-existing medical conditions included: Patient was perfectly healthy with no high blood pressure. Previously, she used to walk 2 to 3 miles every day. The patient was previously treated with dexlansoprazole for stomach issues; and experienced drug allergy when treated with gabapentin, and hydroxychloroquine which caused her to break out in rash. The patient received covid-19 vaccine ad26.cov2.s (suspension for injection, route of admin not reported, batch number: 1808978, expiry: UNKNOWN) dose was not reported, 1 total administered on 26-MAR-2021 for prophylactic vaccination (Dose number in series 1). No concomitant medications were reported. On 09-April-2021 evening, the patient felt an excruciating pain on the back of her head and neck on the right side. She stated that her husband called 911 and she was taken to Medical Center where they did scan and identified that the patient had an aneurysm and a stroke in her brain. The patient stated that the decision was then made (with her daughter authorizing) to have her life flighted to a university since medical center did not have the required equipment to help her. She stated that she had difficulty recalling events but those events were repeated to her and so she knows. Upon arriving at the university, the patient was seen by Doctor (a neurologist) who performed a "coil" operation by inserting "platinum" angioplastic coil into her brain into the aneurysm. She stated that they were able to fix the aneurysm and that she remained in the ICU (Intensive care unit) for 18 days. She stated that they were concerned she may have had a vasospasm that could start another stroke but that did not happen. She states that after being released from the hospital, she had been in rehab and that she is now grateful and happy to be alive but she felt that she was a different person now. She had anxiety about her situation for which the doctor prescribed to her Xanax 1/2mg two to three times a day. She stated that she was calling to report now because she was feeling as she was able to speak more clearly now to the point where she thinks she would be providing helpful information. She stated that she had the drainage stents on the left side of her head and that when it happened, the pain was so excruciating that they had to give her fentanyl to control it. On an Unspecified date the patient experienced fatigue. The patient was admitted to hospital on 09-APR-2021 for unspecified days. The action taken with covid-19 vaccine ad26.cov2.s was not applicable. The patient was recovering from aneurysm in right side of brain, and the outcome of stroke, anxiety and fatigue was not reported. This report was serious (Hospitalization Caused / Prolonged).; Sender's Comments: V0:20211222902 -JANSSEN COVID-19 VACCINE Ad26.COV2.S-  aneurysm in right side of brain, stroke-This event(s) is considered unassessable. The event(s) has a compatible/suggestive temporal relationship, is unlabeled, and has unknown scientific plausibility. There is no information on any other factors potentially associated with the event(s).