a really bad headache that she also described as "debilitating."; high fever of 102 degrees Fahrenheit for 2 days and it was miserable; body aches; lethargy; This is a spontaneous report from a contactable consumer (patient) via Pfizer sponsored program Covax US Support. A 61-year-old female patient received second dose of BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE) via an unspecified route of administration, administered in Arm Left on 01Apr2021 as single dose for covid-19 immunisation. Medical history included severe allergies she had since college, about 30-35 years ago, before both doses of the vaccine, hypothyroidism diagnosed about 3 years ago. Concomitant medications were none.  She has not had any other recent vaccinations or started any new medications. Patient previously received first dose of BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE) administered in left arm in Mar2021 (three weeks before second dose) at the age of 61 years for covid-19 immunisation. Patient got both doses of the Pfizer COVID-19 vaccine. She received the second dose of the Pfizer COVID-19 vaccine last Thursday night on 01Apr2021. She said she was transferred from reporting her reaction to the second dose which included a high fever of 102 degrees Fahrenheit for 2 days (lasted for 48 hours) and it was miserable, body aches, lethargy and a really bad headache that she also described as debilitating (in Apr2021). Her headache began about 10 or 12 hours after her second dose of the vaccine. She took Acetaminophen two pills about every twelve hours, or 6-12 hours starting Friday night until today. She still has a headache. Patient said she understands these are commonly reported reactions and she filed a report with Drug Safety, however, she would like more information on when she can take Tylenol or NSAIDS to help with the headache she continues to experience because she was not sure if it would interact with the vaccine based on what her doctor told her and what she read on our website. She was told she cannot take Ibuprofen for headache before or after vaccine, she was limited to Acetaminophen. She would like to know what she should do if she has continuous headache after vaccine. She said for treatment she was told she cannot take anything but her doctor said she could take Tylenol though when she went on website it said it was not recommended for either Acetaminophen or Ibuprofen, so it also did not recommend Acetaminophen as it can interfere with the activity of COVID-19 vaccine what it is supposed to be doing to build antibodies and immune response and interfere if treat symptoms. She did take Acetaminophen, she had to, for the headaches. Patient stated that she would also like information on when she can safely take an antihistamine like fexofenadine hydrochloride (ALLEGRA) for her allergies because they are rampant right now due to the time of year, she does not want to fexofenadine hydrochloride to interfere with the Pfizer COVID-19 vaccine. Patient wondered when she is considered fully protected after the second dose of the Pfizer COVID-19 vaccine. She has heard one week and two weeks for full protection and she would like clarification on that information. She also would like to know what it means if someone had no reaction after receiving the Pfizer COVID-19 vaccine. Her parents did not have a reaction like she did after they received their vaccines. She wanted to know if that could mean it was not as effective.  Outcome of headache was not recovered, outcome of other events was unknown.   No follow-up attempts are needed. No further information is expected.