Tiredness is better 6 months after 2nd booster; Slight Fever (100.4F) after 2nd Booster; Sore Left Arm Injection Site after 2nd Booster; Swollen glands did not get worst after 2nd booster/Swollen glands did not subside after 2nd booster; This spontaneous case was reported by a patient and describes the occurrence of PYREXIA (Slight Fever (100.4F) after 2nd Booster), VACCINATION SITE PAIN (Sore Left Arm Injection Site after 2nd Booster), LYMPHADENOPATHY (Swollen glands did not get worst after 2nd booster/Swollen glands did not subside after 2nd booster) and FATIGUE (Tiredness is better 6 months after 2nd booster) in a 72-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 066K21A, NDPE 939903, 032M20A and 031L20A) for COVID-19 vaccination.     The patient's past medical history included Tongue dry. Concurrent medical conditions included Atrial fibrillation, Diabetic, Blood pressure high and High cholesterol.   On 16-Feb-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 17-Mar-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 26-Oct-2021, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 04-Apr-2022, received fourth dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 04-Apr-2022, the patient experienced PYREXIA (Slight Fever (100.4F) after 2nd Booster), VACCINATION SITE PAIN (Sore Left Arm Injection Site after 2nd Booster) and LYMPHADENOPATHY (Swollen glands did not get worst after 2nd booster/Swollen glands did not subside after 2nd booster). On an unknown date, the patient experienced FATIGUE (Tiredness is better 6 months after 2nd booster). On 05-Apr-2022, PYREXIA (Slight Fever (100.4F) after 2nd Booster) had resolved. At the time of the report, VACCINATION SITE PAIN (Sore Left Arm Injection Site after 2nd Booster) outcome was unknown, LYMPHADENOPATHY (Swollen glands did not get worst after 2nd booster/Swollen glands did not subside after 2nd booster) had not resolved and FATIGUE (Tiredness is better 6 months after 2nd booster) was resolving.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): In February 2022, Biopsy: abnormal looking glands in neck (abnormal) Biopsy revealed not cancer, abnormal looking glands in neck.. On 04-Apr-2022, Body temperature: 100.4 f (High) 100.4 F. On an unknown date, Biopsy: not enough sample Not enough sample so did second biopsy. On an unknown date, Computerised tomogram: confirmed larger than normal numerous ones (abnormal) Confirmed larger than normal numerous ones. On an unknown date, Ultrasound scan: revealed level 4 carotid canal Revealed level 4 carotid canal.     For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown), the reporter did not provide any causality assessments.   Concomitant product use was not provided by the reporter.  On 26 -Oct-2021, the patient received first booster dose (Lot NDPE 939903).  On 04-Apr-2022, the patient received second booster dose (Lot 066K21A).  In Jan 2022, her glands on both side of neck looked like Mononucleosis, Swollen in neck.  She visited her doctor and needs clinical follow up every 6 months.  On 01 Jun 2022, tiredness was better.  Treatment information was not provided.   This case was linked to MOD-2022-581401 (Patient Link).   Most recent FOLLOW-UP information incorporated above includes: On 01-Jun-2022: Follow up received contains no new information.