Covid test remained positive; This spontaneous case was reported by a nurse and describes the occurrence of COVID-19 (Covid test remained positive) in a 69-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 0171F21, 012M20A and 012L20A) for COVID-19 vaccination.     Previously administered products included for Product used for unknown indication: ALPHAGAN and Demerol. Past adverse reactions to the above products included Allergy with ALPHAGAN and Demerol. Concurrent medical conditions included Hypertension, Low tension glaucoma and Osteopenia. Concomitant products included LISINOPRIL from 02-Jan-2014 to an unknown date for an unknown indication.   On 15-Jan-2021 at 12:00 PM, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 28-Oct-2021 at 12:00 PM, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 16-Feb-2022 at 12:00 PM, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 04-Apr-2022 at 1:00 PM, received fourth dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 24-May-2022 at 12:00 PM, the patient experienced COVID-19 (Covid test remained positive). The patient was treated with NIRMATRELVIR, RITONAVIR (PAXLOVID) from 17-May-2022 to 21-May-2022 for COVID-19 treatment, at an unspecified dose and frequency. At the time of the report, COVID-19 (Covid test remained positive) had not resolved.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On 24-May-2022, SARS-CoV-2 test: positive (Positive) Covid test remained positive..     For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown), the reporter did not provide any causality assessments.   It was reported that 2 days after Paxlovid completed, cough recurred and accompanied by mild runny nose and post nasal drip. Fatigue from initial infection lessened but persisted. The third day after Paxlovid completed, cough worsened though not nearly as intense as initial symptom. COMPANY COMMENT: This is an spontaneous case concerning a 69-years-old female patient with medical history of Allergy treated with ALPHAGAN and Demerol, Concurrent medical conditions included Hypertension, Low tension glaucoma and Osteopenia, Concomitant products included LISINOPRIL, Moderna COVID-19 Vaccine on 1/15, 2/16, 10/28 of 2021 and 4/4/2022, PAXLOVID from 17-May-2022 to 21-May-2022 for COVID-19 treatment who experienced the unexpected event of  COVID-19 49 days after 4th  dose of  mRNA-1273 vaccine. On 24-May-2022, SARS-CoV-2 test: positive The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report. Event´s seriousness assessed as reporting.; Sender's Comments: COMPANY COMMENT: This is an spontaneous case concerning a 69-years-old female patient with medical history of Allergy treated with ALPHAGAN and Demerol, Concurrent medical conditions included Hypertension, Low tension glaucoma and Osteopenia, Concomitant products included LISINOPRIL, Moderna COVID-19 Vaccine on 1/15, 2/16, 10/28 of 2021 and 4/4/2022, PAXLOVID from 17-May-2022 to 21-May-2022 for COVID-19 treatment who experienced the unexpected event of  COVID-19 49 days after 4th  dose of  mRNA-1273 vaccine. On 24-May-2022, SARS-CoV-2 test: positive The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report. Event´s seriousness assessed as reporting.