PMR symptoms; severe osteoarthritis; This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP). The reporter is the patient.  A 64-year-old male patient received BNT162b2 (BNT162B2), on 30Aug2021 as dose 3 (booster), single (Lot number: FE3592) intramuscular for covid-19 immunisation. The patient's relevant medical history included: "knee osteoarthritis", start date: 1990 (ongoing), notes: Pertinent details: Knee replaced 2019; "osteoarthritis moderate", start date: 2018 (ongoing), notes: Pertinent details: mild symptom + R hip osteoarthritis; "Severe shoulder, hip, neck, knee pain", start date: 12Feb2021 (ongoing), notes: Pertinent details: Severe pain at night evening /morning neck, shoulders, hips; "Severe shoulder, hip, neck, knee pain", start date: 12Feb2021 (ongoing), notes: Pertinent details: Severe pain at night evening /morning neck, shoulders, hips; "Severe shoulder, hip, neck, knee pain", start date: 12Feb2021 (ongoing), notes: Pertinent details: Severe pain at night evening /morning neck, shoulders, hips; "Severe shoulder, hip, neck, knee pain", start date: 12Feb2021 (ongoing), notes: Pertinent details: Severe pain at night evening /morning neck, shoulders, hips; "Increase in pain all in parts", start date: 08Mar2021 (ongoing), notes: Pertinent details: CRP 68 PMR , Sed rate (sedimentation rate) 31 diagnosis. There were no concomitant medications. Vaccination history included: BNT162b2 (Dose 1, Date: 02Feb2021, Time: AM, Anatomical Site of injection: Left bicept occ, Route of administration: Intramuscular, Batch/Lot Number: EN5318), administration date: 02Feb2021, for Covid-19 Immunization, reaction(s): "PMR", "severe neck, shoulder, hip pain", "severe neck, shoulder, hip pain", "severe neck, shoulder, hip pain", "Stiffness"; BNT162b2 (Dose 2, Date: 19Feb2021, Time: AM, Anatomical Site of injection: Occ, Route of administration: Intramuscular, Batch/Lot Number: EN6198), administration date: 19Feb2021, for Covid-19 Immunization, reaction(s): "PMR", "severe neck, shoulder, hip pain", "severe neck, shoulder, hip pain", "severe neck, shoulder, hip pain", "Stiffness". The following information was reported: POLYMYALGIA RHEUMATICA (medically significant), outcome "recovering", described as "PMR symptoms"; OSTEOARTHRITIS (medically significant), outcome "recovering", described as "severe osteoarthritis". The patient underwent the following laboratory tests and procedures: C-reactive protein (normal low range 10): (08Mar2021) 68 mg/l, notes: comments: above 10 high; (16Mar2021) 23.9 mg/l, notes: Comments: on 15 mg prednisone OD; (13May2021) 6.2 mg/l, notes: Comments: was on 10 mg prednisone; C-reactive protein (0-5.0): (01Nov2021) 85.49 mg/l, notes: Comments: 7 mg prednisone; C-reactive protein (02-56): (04Aug2021) 10.08 mg/l, notes: Comments: on prednisone 5 mg. Therapeutic measures were taken as a result of polymyalgia rheumatica, osteoarthritis. Clinical course: The reporter stated that I was able to go down on my prednisone from 15 mg QD (every day) to 7 mg QD (every day) over 6 months then I got my booster and my pain came back even worse and my CRP went from 10 before booster to 85 after booster with really extreme PMR symptoms. On 08Mar I had my first CRP but was treated with 40 mg prednisone 5 days which I finished my 5th dose 5Mar. Increase in PMR pain with booster/3rd dose. I went to my 10 mg prednisone then 15 mg and final 20 mg QD (every day) which finally brought some decrease in PMR pain. PMR pain was the worst with 3rd dose. My osteoarthritis has been elaborated my right shoulder + right hip are showing severe osteoarthritis. I am on 15 mg methotrexate 1 week + 11 mg prednisone QD (every day). Vaccination Facility Type is Pharmacy or Drug store. Prior Vaccinations (within 4 weeks): None.  No follow-up attempts are possible. No further information is expected.