Shoulder swelled up all red like 3 bee stings and never goes away/ very swollen and now she can't see her elbow because that part is completely swollen/ swelling on the middle of her arm; Shoulder swelled up all red like 3 bee stings and never goes away/ legs still get very red; Pain from middle of her arm all the way to her hand (radiating down her arm); Swelling on the middle of her arm and elbow; It was hot out and all of a sudden it felt like her legs were on fire; Welts from her leg to below her knee; Cant lift anything; Pain in the elbow; This spontaneous case was reported by a consumer and describes the occurrence of PERIPHERAL SWELLING (Shoulder swelled up all red like 3 bee stings and never goes away/ very swollen and now she can't see her elbow because that part is completely swollen/ swelling on the middle of her arm), ERYTHEMA (Shoulder swelled up all red like 3 bee stings and never goes away/ legs still get very red), PAIN IN EXTREMITY (Pain from middle of her arm all the way to her hand (radiating down her arm)), JOINT SWELLING (Swelling on the middle of her arm and elbow) and FEELING HOT (It was hot out and all of a sudden it felt like her legs were on fire) in a 71-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 031F21A, 027A21A and 031L20A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     The patient's past medical history included Shoulder replacement (Total shoulder replacement left arm) in May 2016. Concurrent medical conditions included Hemorrhoids (14 years old), Temporomandibular joint disorder (Uses a retainer for many years), Anxiety, Depression, Panic attacks, Arthritis, Osteoporosis, Specific allergy (drug) (lidocaine), Specific allergy (drug) (sulfate), Food allergy (corn), Food allergy (peanut butter), Specific allergy (drug) (codeine), Specific allergy (drug) (pseudoephedrine), Penicillin allergy, Fibromyalgia and Inflammation. Concomitant products included POLYCARBOPHIL CALCIUM (FIBERCON) for Bowel discomfort, CYCLOBENZAPRINE for Fibromyalgia, NAPROXEN for Inflammation, DENOSUMAB (PROLIA), VITAMIN D [VITAMIN D NOS], NORTRIPTYLINE, QUETIAPINE FUMARATE (SEROQUEL), LORAZEPAM, ATORVASTATIN, OMEPRAZOLE, BIMATOPROST (LUMIGAN), MACROGOL 400, PROPYLENE GLYCOL (SYSTANE) and CALTRATE + D PLUS for an unknown indication.   On 04-Feb-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 04-Mar-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 26-Oct-2021, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On an unknown date, the patient experienced PERIPHERAL SWELLING (Shoulder swelled up all red like 3 bee stings and never goes away/ very swollen and now she can't see her elbow because that part is completely swollen/ swelling on the middle of her arm), ERYTHEMA (Shoulder swelled up all red like 3 bee stings and never goes away/ legs still get very red), PAIN IN EXTREMITY (Pain from middle of her arm all the way to her hand (radiating down her arm)), JOINT SWELLING (Swelling on the middle of her arm and elbow), FEELING HOT (It was hot out and all of a sudden it felt like her legs were on fire), URTICARIA (Welts from her leg to below her knee), LIMB DISCOMFORT (Cant lift anything) and ARTHRALGIA (Pain in the elbow). The patient was treated with CORTISONE at an unspecified dose and frequency and LIDOCAINE at a dose of patches. At the time of the report, PERIPHERAL SWELLING (Shoulder swelled up all red like 3 bee stings and never goes away/ very swollen and now she can't see her elbow because that part is completely swollen/ swelling on the middle of her arm) and ERYTHEMA (Shoulder swelled up all red like 3 bee stings and never goes away/ legs still get very red) had not resolved and PAIN IN EXTREMITY (Pain from middle of her arm all the way to her hand (radiating down her arm)), JOINT SWELLING (Swelling on the middle of her arm and elbow), FEELING HOT (It was hot out and all of a sudden it felt like her legs were on fire), URTICARIA (Welts from her leg to below her knee), LIMB DISCOMFORT (Cant lift anything) and ARTHRALGIA (Pain in the elbow) outcome was unknown.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On an unknown date, Blood test: it was fine (normal) It was fine. On an unknown date, X-ray: it was fine (normal) It was fine.         Concomitant medications also included and Duplin (vitamin) for depression.  It was reported that swelling was happened 1 to 2 months after receiving the booster. Patient saw her orthopedic doctor who gave a cortisone shot but it was still bad. Then went back and doctor gave lidocaine patches to apply to the swelling on the middle of her arm and elbow. She went outside when it was hot out and all of a sudden it felt like her legs were on fire. She pulled her pants down when she got inside and saw she had welts from her leg to below her knee. This is how she found out she is allergic to lidocaine.  Patient doctor did blood work and x-rays and saw it was fine and was not the shoulder replacement. Patient primary care physician said it was the vaccine. She has never had swelling there and she cant lift anything. Patient arm was basically non-useable.   This case was linked to MOD-2021-034896, MOD-2021-034898 (Patient Link).