pain at the injection site / pain; pain / Throbbing pain / shoulder is throbbing like a tooth ache; shoulder swelled up; fluid in the shoulder and her shoulder grinds; shoulder and collar bone swelled up; can't sleep; 102 fever; nerve pain; felt like electrocuted slowly; shoulder grinds; This case was reported by a consumer via call center representative and described the occurrence of injection site pain in a 68-year-old female patient who received Herpes zoster (Shingrix) for prophylaxis.   The patient's past medical history included injury. Previously administered products included Shingrix with an associated reaction of myalgia (1st dose received on unknown date, refer case US2020AMR045790.). Concurrent medical conditions included muscle injury (due to previous injury). Concomitant products included ibuprofen.   On 20th February 2020, the patient received the 2nd dose of Shingrix (injection). On 22nd February 2020, 2 days after receiving Shingrix, the patient experienced injection site pain, shoulder pain, swollen joints, fluid retention in tissues, bone swelling, sleeplessness, fever, nerve pain, electrocution and joint crepitation. The patient was treated with paracetamol (Acetaminophen), gabapentin, non-drug therapy (Ice Pack (No Medication)) and hydrocodone. On an unknown date, the outcome of the injection site pain, fever, nerve pain, electrocution and joint crepitation were unknown and the outcome of the shoulder pain, swollen joints, fluid retention in tissues, bone swelling and sleeplessness were not recovered/not resolved.   It was unknown if the reporter considered the injection site pain, shoulder pain, swollen joints, fluid retention in tissues, bone swelling, sleeplessness, fever, nerve pain, electrocution and joint crepitation to be related to Shingrix.  Additional case details were reported as follows: The patient reported case for herself. The patient received vaccine in left arm. The patient received Shingrix on Thursday at 11:00 AM and she had a bad experience. The patient claimed that the pharmacist injected the Shingrix right in her auxiliary nerve in the left shoulder and injected the medicine high in her nerve in error.  The more she injected the vaccine, the more excruciating the pain became. The pain never let up and she experienced a 102 degree Fahrenheit fever and her shoulder swelled up. The patient claimed that it felt like she was being electrocuted slowly. The patient administered ice to the area and took a pain pill from her husband which was 5 mg of hydrocodone. The patient went to the urgent care on Monday and they sent her to the emergency rook where they took a computed tomography on her shoulder and it showed fluid in the shoulder and her shoulder grinds. They put her on Gabapentin for nerve pain and she was referred to an orthopedic surgeon on day of reporting. The patient could not sleep on her left side at all and her shoulder and collar bone swelled up. Since Saturday, the symptoms had been the same and it felt like her shoulder was throbbing like a tooth ache which gets worse the more she used it during the day. The patient also reported that her left deltoid muscle was not connected because of a previous injury which was why she believed that the pharmacist made the error because he could not inject the vaccine in her deltoid muscle. The patient was currently taking hydrocodone with acetaminophen for the pain. The emergency room visit was required. The reporter consented to follow up.