Autoimmune Encephalopathy/acquired cognitive dysfunction/ major disruptive disorder/catatonic features/myoclonus/obsessive/staring spells; Obsessive Compulsive behavior; Information has been received from a lawyer regarding a case in litigation concerning a currently adult female patient (pt). No information has been received regarding the pt's past medical history, concurrent conditions, or concomitant medication. It was stated that the pt did not had any autoimmune disease nor autonomic issue previous HPV vaccination. On 15-SEP-2016 (when she was 17 years old), the pt was Inoculated as recommended by the pt's HCP with quadrivalent human papillomavirus (types 6,11,16,18) recomb. vaccine (GARDASIL) or hpv rl1 6 11 16 18 31 33 45 52 58 vlp vaccine (yeast)(GARDASIL 9), as prevention of cervical cancer and an unspecified meningococcal vaccine) (exact dose, route of administration, lot number and expiration date were not provided). On the same date (reported as "30 minutes after received injection with the company unidentified HPV vaccine administered and unspecified meningococcal vaccine, the pt developed high fever of 103 degrees, with aches and pains throughout her entire body. The pt begun to have severe cognitive changes, her inability to focus and learn caused a declined in her high school performance, her level of impairment caused her to be removed from school in her 11 th year due to her inability to concentrate, poor comprehension, and struggles with memory. She also experienced intermittent movements of body jerks (myoclonus), as noted by her primary care physician (PCP) on 02-MAR-2017 ad 17-MAY-2017 and noted by her neurologist in 2017 she developed Acquired Cognitive Dysfunction, Major Disruptive Disorder with catatonic features. Myoclonus, Obsessive Compulsive behavior, and staring spells. The pt condition became so uncontrolled that she was hospitalized on 10-MAR-2018 for 3 days and then was transferred to an  Health institution on 13-MAR-2018, where she remained in hospitalization for another 10 days. The pt was diagnosed with of an Autoimmune Encephalopathy triggered by the HPV vaccination given. At the reporting time, the pt continues to suffer and remains under the care, the pt was unable to do any activities for more than a few hours. Her cognitive behavior was far below expected levels. She had to endure the loss of quality in her life as a direct result of the HPV vaccinations and the inflammatory and autoimmune dysregulation that impacted her brain. The results are permanent and irreversible.  As a proximate result, she suffered and continued to suffer severe and permanent physical injuries and associated symptomology and has suffered severe and permanent emotional injuries, including pain and suffering. She also had a substantial fear of suffering additional and ongoing harms, including but not limited to now being at an increased risk of cancer and future symptoms and harms associated with her autoimmune disease and other injuries caused by HPV vaccine. As a direct and proximate result of her HPV vaccine - induced injuries, she suffered and continued to suffer economic losses, including considerable financial expenses for medical care and treatment, and diminished income capacity, and she will continue to incur these losses and expenses in the future. The outcome of all the events was considered as not resolved. The reporter considered all the events to be related HPV. vaccine.   The above-mentioned events were considered by the reporter as disabling events; however, no specific details were provided.  Upon internal review, the event autoimmune encephalopathy was determined to be medically significant.