Caller states she suffers from Bipolar disorder; Deep depression; This is a spontaneous report from a contactable consumer (patient). A 74-years-old female patient received BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE) dose 1 via an unspecified route of administration, administered in arm left on 06Feb2021 18:00 (Lot Number: EN9581, Expiry Date: May2021) as single dose; dose 2 via an unspecified route of administration, administered in arm left on 27Feb2021 12:30 (Lot Number: EN6201, Expiry Date: Jun2021) as single dose, both dosage at the age of 74-year-old for covid-19 immunisation. Medical history included kidney stones, psoriasis, stenosis, compressed discs in her back, scoliosis back and neck, arthritis of hips, shoulders, knees and fingers , anxiety, ADHD (attention deficit hyperactivity disorder), hypothyroidism, manic period, depression. Family Medical History included patient thought her mother was depressed not after a vaccine just generally depressed and her brother was bipolar, an undiagnosed person. Concomitant medication(s) included clonazepam (KLONOPIN) taken for anxiety from an unspecified start date awhile ago and ongoing; methylphenidate hydrochloride (CONCERTA) taken for ADHD (attention deficit hyperactivity disorder) from an unspecified start date awhile ago and ongoing; methylphenidate hydrochloride (RITALIN) taken for ADHD from an unspecified start date awhile ago and ongoing (patient clarified the concomitant medications are not related to the bipolar specifically and it had also been determined that she had the thing when you are active all the time or when you are little you get this medication for being too active); levothyroxine sodium (SYNTHROID) taken for hypothyroidism from an unspecified start date about 3-4 years ago and ongoing. No additional vaccines administered on same date of the Pfizer suspect. Patient previously received desvenlafaxine succinate (PRISTIQ) for depression; had been on aripiprazole (ABILIFY) 10mg and was reduced to 5mg about a year and a half ago because she had a manic period and reducing the mood stabilizer was one of the things the doctor did to try to stabilize her, she started taking Abilify awhile ago and she went up to the 10mg when she experienced depression. Patient stated she suffered from Bipolar disorder and what happened after the 1st injection was she experienced a descending depression that started probably the 2nd day after on 08Feb2021. Patient stated she then got her 2nd shot and went into a deep depression and continued in a downward sweep. Patient stated it just got worse after the 1st dose and went to a deep depression like bottom depression.  Patient stated her psychiatrist shifted her medications and changed one of the medications and shifted a dosage of another, she took her off Pristiq 100mg every day that she had started years ago. Patient stopped taking that when she contacted her doctor and he switched her over by the 3rd day after the 1st dose of the vaccine to venlafaxine hcl (EFFEXOR), she was switched to Effexor 150mg once a day and she started the day after she stopped the Pristiq. As she kept getting worse he upped her Effexor to 225mg, she took a 150mg and a 75mg each day, after about a week and she kept getting worse. After her 1st vaccination he changed her Abilify which was a mood stabilizer from 5mg to 10mg once daily, she started taking that the same day, the 2nd day after the 1st vaccine. Patient stated she also took Oxybutin but she started that after she had the vaccine and was not relevant. Patient stated her provider was monitoring her carefully and she took awhile to get out of it, it was about 1 month to feel semi human and it has totally resolved now and that would have been about after 2 months. Regarding the onset of events, the patient guessed it started in the morning, she was not getting up in a very good mood. The events did not require a visit to Emergency Room while it could have, her therapist was pushing for that but her psychiatrist said no wait and see what happens, patient stated she was very deeply down and her deeply down can turn into suicide. The events resulted physician office visit. No relevant tests. Outcome of the events was unknown.