she has put on a lot of weight; skin started loosing pigmentation all over her body; her skin has gone from a medium/dark olive complexion to extremely splotchy white splotches. It started on her hands; right hand first, from her knuckles down went white.; This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP). The reporter is the patient.  A 76-year-old female patient received BNT162b2 (BNT162B2), on 03Feb2021 at 10:00 as dose 1, single (Batch/Lot number: unknown) at the age of 76 years, in right arm for covid-19 immunisation. The patient's relevant medical history included: "Hashimoto's disease" (ongoing), notes: Hashimoto's disease, Diagnosed within the last 10 years. Thyroid goes hypo/hyper in the drop of a hat. Doctors have to be careful during surgery when they put her under because her thyroid will change very quickly.; "Emphysema" (ongoing), notes: Emphysema/COPD Diagnosed 30-40 years ago; "COPD" (ongoing), notes: Emphysema/COPD Diagnosed 30-40 years ago; "Water builds up in her brain" (ongoing), notes: Water builds up in her brain, She takes the water pill because she gets water that builds up in her brain. Whenever she tries to stop the medicine, it builds up again really bad. States, you know it's bad when you're trying to think of things and your head is sloshing.; "Thyroid" (unspecified if ongoing), notes: Indication as Reported by the Primary Source: Thyroid; "water pill" (unspecified if ongoing), notes: Indication as Reported by the Primary Source: water pill; "Anxiety" (unspecified if ongoing), notes: Indication as Reported by the Primary Source: Anxiety. Concomitant medication(s) included: LEVOTHYROXINE [LEVOTHYROXINE SODIUM] taken for thyroid disorder; HYDROCHLOROTHIAZIDE taken for diuretic therapy; XANAX taken for anxiety. The following information was reported: SKIN DISCOLOURATION (non-serious) with onset Feb2021, outcome "not recovered", described as "her skin has gone from a medium/dark olive complexion to extremely splotchy white splotches. It started on her hands; right hand first, from her knuckles down went white."; PIGMENTATION DISORDER (non-serious) with onset Feb2021, outcome "not recovered", described as "skin started loosing pigmentation all over her body"; WEIGHT INCREASED (non-serious), outcome "unknown", described as "she has put on a lot of weight". Relevant laboratory tests and procedures are available in the appropriate section. Therapeutic measures were not taken as a result of weight increased, pigmentation disorder, skin discolouration.  Additional information: The patient had no ill effects after getting the 1st dose, except that her skin started losing pigmentation all over her body. When it's on your face it's called melasma; she doesn't know what it's called when it's on the rest of your body. States that her skin has gone from a medium/dark olive complexion to extremely splotchy white splotches. It started on her hands; right hand first, from her knuckles down went white. Weight: because of medical conditions she has put on a lot of weight, she is around 175-180 lbs. The patient did not receive any other vaccines within 4 weeks prior to the COVID vaccine.   The information on the batch/lot number for BNT162b2 has been requested and will be submitted if and when received.