Inflammation wherein there is fluid accumulation on her legs; Inflammation wherein there is fluid accumulation on her legs; the swelling came back again (leg started to swell up along with her left knee)/ that her leg is 3 times its size again; the swelling came back again (leg started to swell up along with her left knee); Inflammation on the knee; Inflammation of the tendon on the back of her leg; Fluid surrounding her knee caused by a cyst behind it; Fluid surrounding her knee caused by a cyst behind it; vision problems; hair has been falling out; Inability to walk very well; has not been able to walk; can't walk; Unable to drive; Horrible headaches; Skin itching; Neck is bothering her; This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP) from medical information team. The reporter is the patient.  A 63-year-old female patient received BNT162b2 (BNT162B2), in 2021 as dose 2, single (Batch/Lot number: unknown) for covid-19 immunisation. The patient's relevant medical history and concomitant medications were not reported. Vaccination history included: Bnt162b2 (DOSE 1, SINGLE), administration date: 2021, for COVID-19 immunization, reaction(s): "Hair loss; hair has been falling out in clumps", "Inflammation on the knee", "Fluid surrounding her knee caused by a cyst behind it", "Inability to walk very well; has not been able to walk; can't walk", "Horrible headaches", "Unable to drive", "Inflammation wherein there is fluid accumulation on her legs", "Fluid surrounding her knee caused by a cyst behind it", "Inflammation wherein there is fluid accumulation on her legs", "Neck is bothering her", "Leg started to swell up along with her left knee", "Skin itching", "Inflammation of the tendon on the back of her leg", "Vision problems"; Bnt162b2, administration date: 2021, for COVID-19 immunization, reaction(s): "Leg started to swell up along with her left knee". The following information was reported: JOINT EFFUSION (medically significant), CYST (medically significant) all with onset 2021, outcome "not recovered" and all described as "Fluid surrounding her knee caused by a cyst behind it"; HEADACHE (non-serious) with onset 2021, outcome "unknown", described as "Horrible headaches"; GAIT DISTURBANCE (non-serious) with onset 2021, outcome "unknown", described as "Inability to walk very well; has not been able to walk; can't walk"; TENDONITIS (medically significant) with onset 2021, outcome "not recovered", described as "Inflammation of the tendon on the back of her leg"; ARTHRITIS (medically significant) with onset 2021, outcome "not recovered", described as "Inflammation on the knee"; INFLAMMATION (medically significant), LOCALISED OEDEMA (medically significant) all with onset 2021, outcome "not recovered" and all described as "Inflammation wherein there is fluid accumulation on her legs"; MUSCULOSKELETAL DISCOMFORT (non-serious) with onset 2021, outcome "unknown", described as "Neck is bothering her"; PRURITUS (non-serious) with onset 2021, outcome "unknown", described as "Skin itching"; IMPAIRED DRIVING ABILITY (non-serious) with onset 2021, outcome "unknown", described as "Unable to drive"; ALOPECIA (non-serious) with onset 2021, outcome "unknown", described as "hair has been falling out"; JOINT SWELLING (medically significant) with onset 2021, outcome "not recovered", described as "the swelling came back again (leg started to swell up along with her left knee)"; PERIPHERAL SWELLING (medically significant) with onset 2021, outcome "not recovered", described as "the swelling came back again (leg started to swell up along with her left knee)/ that her leg is 3 times its size again"; VISUAL IMPAIRMENT (non-serious) with onset 2021, outcome "unknown", described as "vision problems". The events "inflammation wherein there is fluid accumulation on her legs", "the swelling came back again (leg started to swell up along with her left knee)/ that her leg is 3 times its size again", "the swelling came back again (leg started to swell up along with her left knee)", "inflammation on the knee", "inflammation of the tendon on the back of her leg" and "fluid surrounding her knee caused by a cyst behind it" required physician office visit. Therapeutic measures were taken as a result of inflammation, localised oedema, peripheral swelling, joint swelling, arthritis, tendonitis, joint effusion, cyst. Clinical course was also reported as follows: The patient has called Pfizer before, once was earlier this morning and she got no help and was told to go to the website to look up the side effects, but that was no help. The patient had her 2 initial Pfizer shots around 2021 (also reported as Oct2021) and then her first booster and then two weeks ago (Jul2022) she had her second booster. The patient has been having some symptoms that she thought were unrelated to the COVID-19 Vaccine, she had some of the issues over the last year or so and she had a Tele visit appointment, and they thought her symptoms were weird and didn't know what was going on with her either. The patient got the first and second dose of the vaccine as soon as it came out and she had her first booster dose in October last year (as reported). The patient has hair loss, inflammation wherein there is fluid accumulation on her legs which she had taken off at the hospital, has inability to walk very well and is unable to drive. The patient also has horrible headaches and skin itching. For the first 2 doses, she felt thrilled because they were lucky, they didn't have any problems with the first and second doses, however, she didn't realize that she also has other problems that don't go away, and they might be caused by the vaccine. The patient's leg started to swell up along with her left knee. This went for 3 weeks and that it got worse and worse. The patient went to an orthopedic doctor where she was told she had swelling and inflammation on the knee and that there is inflammation of the tendon on the back of her leg and there is fluid surrounding her knee caused by a cyst behind it. This already got drained however, after getting the second dose, the swelling came back again. The patient's leg is 3 times its size again. The patient was not going to go through it again and it's been over 8 months, it still hadn't gone down. Some days are just better than the others. The patient was also having vision problems where she couldn't pinpoint where they're coming from. The patient never had COVID-19, and she never was sick. The patient's hair has been falling out and although her doctor told her it's normal for some medication, she claims that her hair hasn't fallen out despite being on the same medication for 10 years. With this, caller suspects that her symptoms are from the vaccine. The patient wanted to know if anyone else has reported symptoms like this, or if she is coming up with a horrible disease or is this expected. The patient was having an exuberant amount of hair loss that started a year ago. At first, she was thinking, she was just getting older and having hair thinning and it was part of the golden years. The patient's hair is falling out in clumps. The patient has never actually had COVID-19. The patient has been really paranoid of COVID-19 and since she is retired, she doesn't go out, she lets her husband go out, he is the brave one in the family. The patient had swelling in her leg, trouble with her head, her neck is bothering her. The patient has not been able to walk, and she has had to go get fluid removed out of her leg because it was thrice the size, states she can't drive or walk, and she is very limited on what she can do. This all started over a year and a half ago now. If this has something due to the COVID-19 shot, that is fine, but she is spending thousands on tests and things that are finding nothing other than there is fluid and inflammation, but they don't know why. The patient has read the Pfizer COVID-19 Vaccine causes wide spread inflammation in the body and that is why people get myocarditis and other things. They want her to get MRI and CAT Scans done now and she doesn't have the money to do that. Widespread inflammation causes cancer, and she wants to do something about this before that, according to the patient. The patient has been trying to speak with someone at Pfizer about this for 2 days, but she hasn't been able to get anyone that spoke English that she could understand. They kept saying is she needs to go to website and report this. After the Pfizer website was no help, she was reading some stuff online. The patient searched internet for her symptoms and it kept coming up with the COVID-19 shot and that was not what she was trying to find out, but it kept going back to the same thing when she would search exuberant hair loss, inflammation, skin itching. The patient thought maybe there is something to this, maybe it has something to do with the COVID-19 shot. The patient wanted to know if these are possible side effects of the vaccine and if so, how long could they last. The patient also wanted to know if these have been reported before. The patient asked if COVID-19 vaccinations cause hair loss, inflammation, swelling, skin rashes, itching including genital area, and feet feeling tingly, and numb. The patient asked if hair loss without being infected, and inflammation in one leg and one arm and horrible headaches related to the vaccine. The patient asked if others have called in to report the side effects she has. The patient specifically asked for data post-marketing and not during the clinical studies.  The information on the batch/lot number for BNT162b2 has been requested and will be submitted if and when received.; Sender's Comments: Linked Report(s) : US-PFIZER INC-202201016411 Same patient and product; different dose and events;US-PFIZER INC-202201014450 Same patient and product; different dose and events;US-PFIZER INC-202201016413 Same patient and product; different dose and events;