sweaty hands and feet/his hands and feet were sweating and really clammy; tingling in tongue; brain fog for two months; losing weight/States he was 220 pounds.  States not he is around 160-170 pounds; Was walking 5-10 miles a day, has not been; Caller states the she feels her husband is handicapped from this; now introverted where previously he was the life of the party; he's not speaking much; The patient states he feels like he's dying on the inside/She says some doctors say he is depressed but he has never had any kind of mental health disorders; Says his mentality is not right; Abdominal Pain; Says his voice went from being vibrant to low and monotone; flat affect; irregular bowel movements; double vision; Caller says her husband has a small appetite, but he had always previously been an avid eater; This is a spontaneous report from a contactable nurse (patient's wife) and consumer (patient's sister).  A 51-year-old male patient received bnt162b2 (BNT162B2), dose 2 via an unspecified route of administration, administered in Arm Right on 19Feb2021 (Batch/Lot Number: EQ3249) and dose 1 administered in Arm Right on 29Jan2021 (Batch/Lot Number: E19263) as single dose for covid-19 immunisation at the age of 51-year-old.  Medical history included ongoing type 2 diabetes mellitus which was diagnosed 2-3 years ago, the patient was not on insulin or anything, unspecified Allergy, compromised immune status, respiratory illness, genetic/chromosomal abnormalities, endocrine abnormalities, obesity. There were no concomitant medications. The patient experienced losing weight in Feb2021, flat affect in 2021, sweaty hands and feet on 20Feb2021, tingling in tongue in Feb2021, brain fog for two months in Feb2021, irregular bowel movements in 2021, double vision in 2021, small appetite in 2021, was walking 5-10 miles a day, has not been in Feb2021, handicapped from this in 2021, now introverted where previously he was the life of the party in 2021, not speaking much in 2021, feels like he's dying on the inside/she says some doctors say he is depressed but he has never had any kind of mental health disorders in 2021, his mentality is not right in 2021, abdominal pain in 2021, his voice went from being vibrant to low and monotone in 2021.The patient was hospitalized from 07May2021 to 09May2021.The patient underwent lab tests and procedures in 2021 which included colonoscopy: normal, computerised tomogram: normal, echocardiogram: normal, endoscopy gastrointestinal: normal, magnetic resonance imaging: normal, weight: 160-170 pounds, blood test: normal. The outcome of the events was not resolved.  The nurse reported that her husband received his second dose of the Pfizer BioNtech covid 19 vaccine on 19Feb2021. The next day he woke up with the following symptoms: sweaty hands and feet, tingling in tongue, brain fog for 2 months, irregular bowel movements, double vision, and flat affect. The nurse reports he was now introverted where previously he was the life of the party, he's not speaking much, not doing things he previously enjoyed such as previously doing yard work, driving, and walking 5-10 miles every morning. He is losing weight without trying 220 lbs to 160-170 lbs now. The nurse reported they have been in and out of the emergency room and sought medical care from many different people including a psychiatrist. The nurse reported they have had labs and bloodwork drawn that all resulted normal. The patient states he feels like he's dying on the inside. The nurse was seeking treatment recommendations as one doctor suggested that these reported symptoms could be caused from the Pfizer BioNtech covid 19 vaccines. He has been losing weight and his affect and demeanor are different since he got the second vaccine. They have been to every doctor and specialists. His blood work is perfect, and they cannot find out what is wrong with him. The nurse says that her husband was happy and jovial. he was 220 pounds and now is around 160-170 pounds. his mentality is not right; he has no affect. he used to be cutting grass and gardening. Now he is not speaking to family and friends; he is not even speaking to her as much. no one knows what is wrong. The nurse states that several doctors believe it to be from the vaccine because nothing happened until after the second dose of the vaccine. The nurse is uncertain about this. He has lost weight quickly. On 20Feb2021: He woke up and his hands and feet were sweating and really clammy. States she could touch them and feel the moisture. He went to the (privacy) and they gave him a roll-on for his hands. The following week he kept saying that his tongue was tingling; like as if he had bit it. He started seeing the dentist about it and they prescribed medications. A week after the tongue tingling he started experiencing brain fog. She states this brain fog lasted for 2 months. Along with the brain fog, he started to lose weight and complain of intense abdominal discomfort, Abdominal pain. He said that his bowel movements were not regular. He went to a gastroenterologist and they did a colonoscopy and EGD and found nothing on these tests. He  kept the gastrointestinal issues for a long time. he has been wearing glasses because he is nearsighted. After the vaccine he complained of double vision. He saw his optometrist who said everything was fine. He has been in and out of the emergency room. Everyone says that he is fine. All of his labs are within normal limits; blood work, urine tests, and stool. He is steadily losing weight; he was 220 pounds, now he is 160-170 pounds. He was bright and affectionate. And he loves the outdoors and would walk 5-10 miles a day. But he has not been walking since Feb2021. He has a small appetite, but he had always previously been an avid eater. He was admitted into the hospital around 07May2021-09May2021. She had to push for that admission. her husband would wake up every morning saying he felt like he was about to die. she has been taking him to the emergency room about twice a week since February. While hospitalized he had CT Scans, MRI, Echocardiogram, and nothing was found on these tests. she feels her husband is handicapped from this. Their daughter is getting married, they are about to be grandparents, and her husband's affect is just flat. She says some doctors say he is depressed but he has never had any kind of mental health disorders. she has not seen her husband smile since February or March. his voice went from being vibrant to low and monotone.  Patient's sister reported Her brother was fine, he had the first one then he got the second one and after the second one he is now having these foggy brain, mental kind of stuff happen. He got it in February and it started right there after, this is still going on and she wants to know how long it may last.  No follow-up attempts are needed. No further information expected.; Sender's Comments: Based on close temporal association there is reasonable possibility of causal association between the reported serious events and the suspect drug Comirnaty. The impact of this report on the benefit/risk profile of the Pfizer product is evaluated as part of Pfizer procedures for safety evaluation, including the review and analysis of aggregate data for adverse events. Any safety concern identified as part of this review, as well as any appropriate action in response, will be promptly notified to regulatory authorities, Ethics Committees, and Investigators, as appropriate