extreme swelling and pain in hands and all joints; extreme swelling and pain in hands and all joints; hands, fingers and arms tingling; Legs feel numb and hurt at night; Legs feel numb and hurt at night; vitiligo spread exponentially and still spreading; low IgM and IgG class 4 antibodies; This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP). The reporter is the patient.  A 65-year-old female patient (not pregnant) received BNT162b2 (BNT162B2), on 02Jul2022 as dose 4 (booster), single (Lot number: FP7135) at the age of 65 years, in left arm for covid-19 immunisation. The patient's relevant medical history included: "hashimotos" (unspecified if ongoing); "vitiligo" (unspecified if ongoing); "sjogrens" (unspecified if ongoing); "possible RA" (unspecified if ongoing); "covid" (unspecified if ongoing), notes: If covid prior vaccination: Yes. Concomitant medication(s) included: CYMBALTA; AMBIEN; RAMIPRIL; LEVOXYL; LEVOTHYROXINE [LEVOTHYROXINE SODIUM]. Vaccination history included: BNT162b2 (Dose Number: 3, Lot No: FF2587, Location of injection: Arm Left), administration date: 26Sep2021, when the patient was 64-year-old, for Covid-19 immunization; BNT162b2 (Dose Number: 2, Lot No: ER2613, Location of injection: Arm Left), administration date: 19Mar2021, when the patient was 63-year-old, for Covid-19 immunization; BNT162b2 (Dose Number: 1, Lot No: EN6206, Location of injection: Arm Left), administration date: 02Mar2021, when the patient was 63-year-old, for Covid-19 immunization, reaction(s): "vitiligo spread exponentially". The following information was reported: HYPOAESTHESIA (non-serious), PAIN IN EXTREMITY (non-serious) all with onset 03Jul2022, outcome "not recovered" and all described as "Legs feel numb and hurt at night"; PARAESTHESIA (non-serious) with onset 03Jul2022, outcome "not recovered", described as "hands, fingers and arms tingling"; ANTIBODY TEST ABNORMAL (non-serious) with onset 03Jul2022, outcome "not recovered", described as "low IgM and IgG class 4 antibodies"; VITILIGO (non-serious) with onset 03Jul2022, outcome "not recovered", described as "vitiligo spread exponentially and still spreading"; SWELLING (non-serious), ARTHRALGIA (non-serious) all with onset 04Jul2022, outcome "not recovered" and all described as "extreme swelling and pain in hands and all joints". The events "extreme swelling and pain in hands and all joints", "hands, fingers and arms tingling", "legs feel numb and hurt at night", "vitiligo spread exponentially and still spreading" and "low IGM and IGG class 4 antibodies" required physician office visit. Relevant laboratory tests and procedures are available in the appropriate section. Therapeutic measures were taken as a result of swelling.  Additional information: There was no other vaccine in four weeks. Legs feel numb and hurt at night. After second booster shot two days later, extreme swelling and pain in hands and all joints. It has been two weeks and swelling still there and very painful, hands, fingers and arms tingling. After first shot, vitiligo spread exponentially and still spreading. Also now have low IgM and IgG class 4 antibodies. Treatment includes medrol pack for swelling which did not work.