difficulty breathing/breathing problems; increased blood pressure/blood pressure really high; itching incessantly; This is a spontaneous report from a contactable other health professional (patient) received via Medical Information Team. A 58-year-old female patient received second dose of BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE), via an unspecified route of administration, administered in arm right on 12Mar2021 at 09:30 (Lot Number: EN6198) (at the age of 58-year-old) as single dose for COVID-19 immunisation.  Medical history included a couple of surgeries, prediabetic, breaking out with blisters on chin, hormone replacement, insomnia, muscle pain, blood pressure abnormal, depression, iron deficiency, allergies and itching, all from an unknown date and unknown if ongoing. Concomitant medications included metformin (formulation: tablet) oral at 500 mg once a day taken for prediabetic from 2019 and ongoing; acyclovir at 400 mg twice a day taken for breaking out with blisters on chin from an unspecified start date and ongoing; estradiol (formulation: tablet) at 1 mg once a day taken for hormone replacement from 2019 and ongoing; medroxyprogesterone acetate (PROVERA) at 2.5 mg once a day taken for hormone replacement therapy from 2019 and ongoing; trazodone HCl (formulation: tablet) at 100 mg once a day taken for insomnia from 2016 and ongoing; meloxicam at 15 mg once a day taken for muscle pain from 2016 to an unspecified stop date; hydrochlorothiazide at 50 mg once a day taken for blood pressure abnormal from 2016 and ongoing; buspirone (formulation: tablet) at 10 mg thrice a day taken for depression from 2016 and ongoing; ferrous sulfate (FEROSUL, formulation: tablet) at 65 mg twice a day taken for iron deficiency from 2016 and ongoing; cetirizine (formulation: tablet) at 10 mg once a day taken for allergies from Feb2021 and ongoing; hydroxyzine (formulation: tablet) oral at 25 mg  taken for itching from Feb2021 and ongoing. The patient previously received first dose of BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE), intramuscular, administered in arm left on 19Feb2021 (Lot Number: EN6200) (at the age of 58-year-old) as single dose for COVID-19 immunisation. The patient reported that blood pressure was really high on 09Apr2021. On 10Apr2021 she woke up from sleeping due to difficulty breathing/breathing problems and went to the emergency room (ER) at 03:00. Caller stated they found out in the ER that her blood pressure was high. She stated that in the ER they didn't do anything but took her blood pressure and watched her blood pressure. Caller stated she was not admitted, she was there for 4 hours and sent home. Caller stated her blood pressure was over 200 and they still let her go home. Caller stated she went into the doctor on 12Apr2021 at 15:00 and got some medicine for the itching, at that time her blood pressure was down. Patient stated that itching could have been a reaction from one of the drugs she was given. Therapeutic measures were taken as a result of the blood pressure, the patient started a new medication, LOSARTAN at 50mg one time a day and got some medicine for the itching. The patient outcome of difficulty breathing/breathing problems and increased blood pressure/blood pressure really high was recovering and of itching was not recovered.  No follow-up attempts are needed. No further information is expected.; Sender's Comments: The contributory role of the suspect product BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE) (Lot Number: EN6198), to reported events is possible. Tis case will be reassessed if follow-up information is received.