Swelling; Hand swelling; Cramps in legs; Sinus infection; Urinary tract infection; Covid-19; Vaccination site inflammation; Pain in hand; Hand injury; Osteoarthritis; Stiffness; Depression; This spontaneous case was reported by a consumer and describes the occurrence of LIMB INJURY (Hand injury), OSTEOARTHRITIS (Osteoarthritis), MUSCULOSKELETAL STIFFNESS (Stiffness), DEPRESSION (Depression) and SWELLING (Swelling) in a 67-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.    Co-suspect product included non-company product ADALIMUMAB (HUMIRA) solution for injection for Rheumatoid arthritis.    No Medical History information was reported.   On an unknown date, the patient received dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form On an unknown date, received dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. and ADALIMUMAB (HUMIRA) (Subcutaneous) Solution for injection in pre-filled pen, Citrate Free. In 2021, the patient experienced DEPRESSION (Depression). On an unknown date, the patient experienced LIMB INJURY (Hand injury), OSTEOARTHRITIS (Osteoarthritis), MUSCULOSKELETAL STIFFNESS (Stiffness), SWELLING (Swelling), PERIPHERAL SWELLING (Hand swelling), MUSCLE SPASMS (Cramps in legs), SINUSITIS (Sinus infection), URINARY TRACT INFECTION (Urinary tract infection), COVID-19 (Covid-19), VACCINATION SITE INFLAMMATION (Vaccination site inflammation) and PAIN IN EXTREMITY (Pain in hand). At the time of the report, LIMB INJURY (Hand injury), MUSCULOSKELETAL STIFFNESS (Stiffness), COVID-19 (Covid-19) and VACCINATION SITE INFLAMMATION (Vaccination site inflammation) had resolved, OSTEOARTHRITIS (Osteoarthritis), DEPRESSION (Depression), PERIPHERAL SWELLING (Hand swelling) and PAIN IN EXTREMITY (Pain in hand) had not resolved, SWELLING (Swelling) and MUSCLE SPASMS (Cramps in legs) was resolving and SINUSITIS (Sinus infection) and URINARY TRACT INFECTION (Urinary tract infection) outcome was unknown.            Concomitant and treatment medications were not reported.  On unknown dates, the patient experienced increased inflammation following the Moderna vaccinations, left hand had become more damaged and stiff due to Moderna vaccine, osteoarthritis, swelling, pain and swelling in hands due to Moderna vaccine, covid, urinary tract infection, sinus infection symptoms and cramps in legs and ankles/notices this sensation when completely relaxed. In 2021, the patient experienced depression/dramatic loss of family in one year. On unknown dates, increased inflammation following the Moderna vaccinations, left hand had become more damaged and stiff due to Moderna vaccine and covid resolved.  It was unknown if patient was enrolled in a COVID-19 Vaccine Trial.  Causality for HUMIRA(ADALIMUMAB): The reporter's causality for the events of increased inflammation following the Moderna vaccinations, left hand had become more damaged and stiff due to Moderna vaccine unknown onset, osteoarthritis, left hand had become more damaged and stiff due to Moderna vaccine, depression/dramatic loss of family in one year, pain and swelling in hands due to Moderna vaccine, pain and swelling in hands due to Moderna vaccine, COVID and cramps in legs and ankles/notices this sensation when completely relaxed with HUMIRA(ADALIMUMAB) was no reasonable possibility. The reporter's causality for the events of swelling, urinary tract infection and sinus infection symptoms was not provided.  This case was identified as part of a retrospective clean-up activity where certain emails received in the Moderna mailbox were missed to be booked-in.