After his 2nd COVID-19 Vaccine shot on Friday (07May2021), around Sunday (09May2021) parts of the middle of his hand to the middle of his fingers got red; After his 2nd COVID-19 Vaccine shot on Friday (07May2021), around Sunday (09May2021) parts of the middle of his hand to the middle of his fingers got a little cold, as well as, his nose; He had intermittent chills; This is a spontaneous report from a contactable consumer (patient).   A 74-years-old male patient received bnt162b2 (PFIZER-BIONTECH COVID-19 VACCINE, Solution for injection, Batch/Lot Number: ER8736, Expiration Date: 31Jul2021), via an unspecified route of administration, administered in Arm Left on 07May2021 13:00 (at the age of 74-year-old) as DOSE 2, SINGLE for covid-19 immunisation. Medical history included prostate cancer from 2019 (his prostate cancer right now, was not detectable by blood work, but the prostate cancer had spread to the lymph nodes in his left groin. He said he had chemotherapy clarified as Docetaxel and Carboplatin (that he completed around Jun2019 or Jul2019), 26 radiation treatments, and Lupron, which prohibited his testosterone and took away all his strength. (No further details provided), lymphoedema from 2020 (he believed his lymphedema in his legs was caused by the 26 radiation treatments he was given for his prostate cancer. He said his radiation treatments ended in late Dec2019 (just before Christmas), and the lymphedema in his legs started in the beginning of 2020. He said the lymphedema in his legs was almost unnoticeable and the lymphedema felt like clamps on the nerves in his legs. No further details provided), radiotherapy from an unknown date to 2019 (26 radiation treatment for prostate cancer). The patient concomitant medications were not reported. The patient previously took bnt162b2 (Lot Number: EW0150 and Expiration Date: 31Jul2021) via intramuscular route in left arm on 16Apr2021 as DOSE 1, SINGLE for covid-19 immunisation. Also received lupron for androgen deficiency, carboplatin, taxotere. Additional vaccines administered on same date of the Pfizer suspect was reported as none. Patient reported that after his second COVID-19 Vaccine shot on Friday (07May2021) around Sunday (09May2021) parts of the middle of his hand to the middle of his fingers got red and a little cold. He said his nose was a little cold (clarifying he had no redness on his nose) and he had intermittent chills. He said he still had lymphedema (in his legs from radiation treatments for prostate cancer) and was wondering if the lymphedema may be contributing to what he was experiencing in his hands and nose. He clarified the redness on his hands and fingers was lighter in the morning and was not as bad as when it initially started on Sunday. He said his hands and fingers were very very red on Sunday. He said his hand and finger redness and coldness still comes back but was not as bad now. He said the tip of his nose still got cold, but it was sporadic. He said his nose was fine right now, but an hour before the tip of his nose was a bit cold. He said his intermittent chills had subsided, but he sometimes had a little twinge. He said he did not have real bad chills, and that all his symptoms were a low level and intermittent. Reported he had been looking at his hands for the past couple days now and he still had the redness and cold feeling and was wondering if it was due to his second COVID-19 Vaccine dose. He said there was nothing debilitating about his symptoms and he was not overly concerned. On subsequent follow-ups he reported that on Sunday (09May2021) he noticed redness and coldness in the middle of his hand and into his fingers, coldness on the tip of his nose but no redness and intermittent chills that were mild. It was now 1/5th of what it was it was not cold anymore, and not as red so its subsiding. Caller stated he had been taking chemotherapy agents docetaxal/Docefrez (DSC Taxotere) and Carboploatin but was finished with those for a year before receiving the vaccine. He had an anaphylaxis reaction three times to one of the medications, was given Oxygen and Benadryl. There was concern before he got the vaccine because of the polyethylene glycol in the vaccine, and he believes one of the chemo agents contains it as well. Even though he had no problems with the first dose he wonders if it maybe caused his reaction to the second dose. Response was provided by agent that Polyethylene glycol-2000 is an ingredient of the vaccine but agent have no information on what kind of reaction someone may have to it. Suggested he speak to his doctor or pharmacist to see if the PEG the chemo agent was animal/plant derived versus synthetic. Reporter seriousness for events was provided as unspecified. The patient underwent lab tests and procedures which included computerised tomogram pelvis with iodine contrast: normal and, urine analysis: normal on 16Apr2021. Treatment was not received for adverse events. The adverse events did not require to visit to emergency room or Physician office. The outcome of the events was recovering.   No follow-up attempts are needed. No further information is expected.