This spontaneous case was reported by a patient and describes the occurrence of IMMUNISATION REACTION (mild to moderately severe reactions/his body reacting to something), PRURITUS (itching), INSOMNIA (not able to sleep), PYREXIA (fever) and MYALGIA (body aches) in a 55-year-old male patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 051B22A, 051F21A, 020B21A and 013421A) for COVID-19 prophylaxis. The occurrence of additional non-serious events is detailed below. No Medical History information was reported. On 25-Feb-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 25-Mar-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 05-Dec-2021, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 16-Jul-2022, received fourth dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. In 2022, the patient experienced IMMUNISATION REACTION (mild to moderately severe reactions/his body reacting to something), PYREXIA (fever), MYALGIA (body aches), FATIGUE (tiredness) and PAIN IN EXTREMITY (sore arm). In July 2022, the patient experienced PRURITUS (itching), INSOMNIA (not able to sleep), RASH ERYTHEMATOUS (red small spot on his hand/spots progressively went worse) and RASH (all kinds of rashes/very unusual line with 2, 3, 5 inches long appeared/a large area got aggravated/rashes are up/getting progressively worse). The patient was treated with DIPHENHYDRAMINE HYDROCHLORIDE (BENADRYL [DIPHENHYDRAMINE HYDROCHLORIDE]) at an unspecified dose and frequency and CETIRIZINE HYDROCHLORIDE (ZYRTEC [CETIRIZINE HYDROCHLORIDE]) at an unspecified dose and frequency. In 2022, IMMUNISATION REACTION (mild to moderately severe reactions/his body reacting to something), PYREXIA (fever), MYALGIA (body aches), FATIGUE (tiredness) and PAIN IN EXTREMITY (sore arm) had resolved. At the time of the report, PRURITUS (itching), RASH ERYTHEMATOUS (red small spot on his hand/spots progressively went worse) and RASH (all kinds of rashes/very unusual line with 2, 3, 5 inches long appeared/a large area got aggravated/rashes are up/getting progressively worse) had not resolved and INSOMNIA (not able to sleep) outcome was unknown. No concomitant medication were provided. It was reported that 1 week after the 2nd booster, on July 25 or 26th coming back from work patient noticed a red small spot on hand which slowly went away and the next day at night two small things on body were itching, they were small, patient though it was an insect bite, it was very itchy, patient took a Benadryl just to sleep on Wednesday that week. On the 27-Jul-2022 it happened again and from Thursday 28th the spots progressively went worse. Patient started to experience all kinds of rashes which "come and go", and went to Urgent Care. Patient's HCP made patient to have blood tests and pharmacist told that it was patient's immune system. Patient's doctor asked about new medication but did not change anything. Further it was reported that A very unusual line with 2, 3, 5 inches long appeared and some of them "are round or rectangular, extremely unusual". It has been 3 weeks and it was getting worse" and when touched it a large area got aggravated. Patient was not able to sleep last night. HCP told that it was patient's body reacting to something, patient blood tests came back normal "everything fine within normal range" Patient cleaned the house and it got really bad as "it was taking too long". Patient took Zyrtec and at night Benadryl, took a cold shower and aloe vera. Further it was reported that patient expected the sore arm, body ache for a day an a half or two there was no additional problems. This last booster, a week after the injection, the rashes are up and are still getting progressively worse. Most recent FOLLOW-UP information incorporated above includes: On 24-Aug-2022: Live follow up received included Significant information dosing details and narrative was updated.