This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP) from medical information team. The reporter is the patient. A 74 year-old male patient received bnt162b2 (BNT162B2), administered in arm left, administration date 23Mar2022 (Batch/Lot number: unknown) at the age of 74 years as dose 4 (booster), single for Covid-19 immunisation. Relevant medical history included: "Polio Survivor" (unspecified if ongoing); "COPD" (unspecified if ongoing); "Type 2 Diabetes" (unspecified if ongoing); "Heart Arrhythmia" (unspecified if ongoing); "Compromised Lung Function" (unspecified if ongoing); "immunocompromised" (unspecified if ongoing). There were no concomitant medications. Vaccination history included: Bnt162b2 (Dose 1, Lot number: EN5318), administration date: 30Jan2021, when the patient was 73 years old, for COVID-19 immunization, reaction(s): "little arm soreness", "Tiredness"; Bnt162b2 (Dose 2, Lot number: EL8982), administration date: 20Feb2021, when the patient was 73 years old, for COVID-19 immunization, reaction(s): "Little arm soreness", "Tiredness"; Bnt162b2 (Dose 3), administration date: 26Aug2021, when the patient was 74 years old, for COVID-19 immunization, reaction(s): "Little arm soreness", "Tiredness". The following information was reported: PYREXIA (non-serious) with onset 24Mar2022, outcome "recovered" (28Mar2022), described as "fever for 3-4 days"; PERIPHERAL SWELLING (non-serious), MUSCLE SWELLING (non-serious) all with onset 24Mar2022, outcome "recovering" and all described as "swollen arm and muscle"; AXILLARY MASS (non-serious) with onset 24Mar2022, outcome "recovering", described as "lump below the injection site"; DIZZINESS (non-serious) with onset 24Mar2022, outcome "not recovered", described as "little bit of dizziness/dizzy/light-headed"; FATIGUE (non-serious) with onset 24Mar2022, outcome "recovering", ASTHENIA (non-serious) with onset 24Mar2022, outcome "not recovered" and all described as "extremely tired with total loss of energy"; MYALGIA (non-serious) with onset 24Mar2022, outcome "recovering", described as "some muscle pain/sore muscle"; BACK PAIN (non-serious) with onset 24Mar2022, outcome "recovering", described as "lower back pain"; LETHARGY (non-serious) with onset 24Mar2022, outcome "recovering", described as "lethargic". Relevant laboratory tests and procedures are available in the appropriate section. Additional information: The patient did not have any family medical history relevant to adverse events. The facility where the most recent COVID-19 vaccine was administered was Pharmacy/Drug Store. The vaccine was not administered at Military facility. On 23Mar2022, the patient received the 4th booster shot and experienced a swollen arm and muscle, sore muscle, a lump below the injection site, a fever for 3-4 days, a little bit of dizziness and was extremely tired with total loss of energy, he was in bed for 3-4 days. Fever was seeming to subside that day. The fever seems to be gone, but he was still very tired. He was also dizzy. Symptoms had improved some but were still there. He did not experience these with the first 3 shots, just a little arm soreness and tiredness. The extreme tiredness where the patient was in bed for 3-4 days and the fever he did not have before (with previous shots). He was immunocompromised. He had a heart arrhythmia, type 2 Diabetes, COPD. He stated he had some muscle and lower back pain. The fever had already broken and returned to normal. His major concern was the tiredness. He really felt totally lethargic. The caller stated that when a person is old they are a little dizzy when going from sitting to standing up, but this was more than that. The caller stated that it started the day after on 24Mar2022 and it had improved but he was still lightheaded. The caller stated that his side effects were ongoing with a slight improvement. The only thing that had recovered yesterday was his temperature increase dropped and today it appeared to be normal now. The caller wanted to know if it was normal to experience these and if these symptoms were normal. The adverse events did not require a visit to Emergency room or Physician office. No relevant tests were done. The lot number for bnt162b2 was not provided and will be requested during follow up.