Overload on immune system; Immunoglobulin G tested low; Immunoglobulin E tested high; Immunoglobulin A tested high; Platelets high, CD57 high (all new except possibly platelets); Hot flashes multiple times per hour lasting for about 1 month; menstruation ended (for 111 days, then resumed); menstruation ended (for 111 days, then resumed); menstruation ended (for 111 days, then resumed); extreme, debilitating fatigue to the point of interfering with everyday life; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP). The reporter is the patient.  A 46 year-old female patient (not pregnant) received bnt162b2 (BNT162B2), administered in arm left, administration date 21Apr2021 (Lot number: EW 0171) at the age of 46 years as dose 2, single for covid-19 immunisation. Relevant medical history included: "Chronic Fatigue Immune Deficiency" (unspecified if ongoing), notes: Chronic Fatigue Immune Deficiency; "Post treatment lyme syndrome" (unspecified if ongoing), notes: Post treatment lyme syndrome; "adrenal insufficiency" (unspecified if ongoing); "Factor V Leiden mutation-1 copy" (unspecified if ongoing), notes: Factor V Leiden mutation-1 copy; "Known allergies: milk" (unspecified if ongoing), notes: Known allergies: milk; "Known allergies: eggs" (unspecified if ongoing), notes: Known allergies: eggs; "Known allergies: shellfish" (unspecified if ongoing), notes: Known allergies: shellfish; "Known allergies: yeast" (unspecified if ongoing), notes: Known allergies: yeast. The patient took concomitant medications. Past drug history included: Prilosec, reaction(s): "Known allergies: Prilosec", notes: Known allergies: Prilosec; Cefotetan, reaction(s): "Known allergies: Cefotetan", notes: Known allergies: Cefotetan; Amytriptoline, reaction(s): "Known allergies: Amytriptoline", notes: Known allergies: Amytriptoline. Vaccination history included: Bnt162b2 (product=COVID 19, brand= Pfizer, lot number=EP7533, lot unknown=False, administration date=29Mar2021, dose number=1, Vaccine location=Left arm), administration date: 29Mar2021, when the patient was 46 years old, for COVID-19 immunization. The following information was reported: IMMUNE SYSTEM DISORDER (non-serious) with onset 12May2021, outcome "recovering", described as "Overload on immune system"; BLOOD IMMUNOGLOBULIN G DECREASED (non-serious) with onset 12May2021, outcome "recovering", described as "Immunoglobulin G tested low"; BLOOD IMMUNOGLOBULIN E INCREASED (non-serious) with onset 12May2021, outcome "recovering", described as "Immunoglobulin E tested high"; BLOOD IMMUNOGLOBULIN A INCREASED (non-serious) with onset 12May2021, outcome "recovering", described as "Immunoglobulin A tested high"; PLATELET COUNT INCREASED (non-serious) with onset 12May2021, outcome "recovering", described as "Platelets high, CD57 high (all new except possibly platelets)"; HOT FLUSH (non-serious) with onset 12May2021, outcome "recovering", described as "Hot flashes multiple times per hour lasting for about 1 month"; AMENORRHOEA (non-serious), MENSTRUATION IRREGULAR (non-serious), MENSTRUAL DISORDER (non-serious) all with onset 12May2021, outcome "recovering" and all described as "menstruation ended (for 111 days, then resumed)"; FATIGUE (non-serious) with onset 12May2021, outcome "recovering", described as "extreme, debilitating fatigue to the point of interfering with everyday life". The events "overload on immune system", "immunoglobulin g tested low", "immunoglobulin e tested high", "immunoglobulin a tested high", "platelets high, cd57 high (all new except possibly platelets)", "hot flashes multiple times per hour lasting for about 1 month", "menstruation ended (for 111 days, then resumed)", "menstruation ended (for 111 days, then resumed)", "menstruation ended (for 111 days, then resumed)" and "extreme, debilitating fatigue to the point of interfering with everyday life" were evaluated at the physician office visit. Relevant laboratory tests and procedures are available in the appropriate section. Therapeutic measures were not taken as a result of immune system disorder, blood immunoglobulin g decreased, blood immunoglobulin e increased, blood immunoglobulin a increased, platelet count increased, hot flush, amenorrhoea, menstruation irregular, menstrual disorder, fatigue.  Additional information: Facility type vaccine: Pharmacy or Drug Store. No other vaccine in four weeks. Patient took other medications in two weeks. Unknown if covid prior to vaccination. No covid tested post vaccination.  Follow-up attempts are completed. No further information is expected.