hands have less flexibility than a month ago; knuckles are swelling, swelling increases with time; sometimes scratch and rub eyes; Big blisters; Disguising rash on my back and arms with welts; Conjunctivitis; Joint pain in his fingers/the joint pain is progressive/pain started on the outside fingers of the pinkle and index fingers; very itchy eyes, that are getting progressively worse; patchy rash on his back, shoulders, buttock and arms/patchy rash is on his scalp and beard/rash all over his back/ rash all over his back and shoulders/disgusting rash on back and arms With welts; getting worse/join pain progressive/ joint pain in hands, slowly gelling worse, symptoms condition aggravated/very itchy eyes, getting progressively worse/knuckles swelling, swelling increasing; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP). The reporter is the patient. Other Case identifier(s):   A 73-year-old male patient received BNT162b2 (BNT162B2), in 2022 as dose 1, single (Batch/Lot number: unknown) for covid-19 immunisation. The patient's relevant medical history included: "Egg Allergy" (ongoing); "Gluten allergy" (ongoing); "Rash" (unspecified if ongoing); "surgery on his hand", start date: 2019 (unspecified if ongoing); "big blisters" (unspecified if ongoing); "Food allergy" (unspecified if ongoing). Concomitant medication(s) included: DEXAMETHASONE; NEOMYCIN SULFATE. The following information was reported: BLISTER (non-serious) with onset 2022, outcome "recovered", described as "Big blisters"; CONJUNCTIVITIS (non-serious) with onset 2022, outcome "recovering"; URTICARIA (non-serious) with onset 2022, outcome "recovered", described as "Disguising rash on my back and arms with welts"; ARTHRALGIA (non-serious) with onset 2022, outcome "not recovered", described as "Joint pain in his fingers/the joint pain is progressive/pain started on the outside fingers of the pinkle and index fingers"; CONDITION AGGRAVATED (non-serious) with onset 2022, outcome "unknown", described as "getting worse/join pain progressive/ joint pain in hands, slowly getting worse, symptoms condition aggravated/very itchy eyes, getting progressively worse/knuckles swelling, swelling increasing"; MUSCLE RIGIDITY (non-serious) with onset 2022, outcome "not recovered", described as "hands have less flexibility than a month ago"; SWELLING (non-serious) with onset 2022, outcome "not recovered", described as "knuckles are swelling, swelling increases with time"; RASH (non-serious) with onset 2022, outcome "recovered", described as "patchy rash on his back, shoulders, buttock and arms/patchy rash is on his scalp and beard/rash all over his back/ rash all over his back and shoulders/disgusting rash on back and arms With welts"; SUPERFICIAL INJURY OF EYE (non-serious) with onset 2022, outcome "unknown", described as "sometimes scratch and rub eyes"; EYE PRURITUS (non-serious) with onset 2022, outcome "unknown", described as "very itchy eyes, that are getting progressively worse". The events "hands have less flexibility than a month ago", "knuckles are swelling, swelling increases with time", "sometimes scratch and rub eyes", "big blisters", "disgusting rash on my back and arms with welts", "conjunctivitis", "joint pain in his /the joint pain is progressive/pain started on the outside fingers of the pinkle and index fingers", "very itchy eyes, that are getting progressively worse", "patchy rash on his back, shoulders, buttock and arms/patchy rash is on his finger, scalp and beard/rash all over his back/ rash all over his back and shoulders/disgusting rash on back and arms with welts" and "getting worse/join pain progressive/ joint pain in hands, slowly gelling worse, symptoms condition aggravated/very itchy eyes, getting progressively worse/knuckles swelling, swelling increasing" required physician office visit. Therapeutic measures were taken as a result of superficial injury of eye, conjunctivitis, eye pruritus, condition aggravated. Additional information: This case involves a 73 years old male patient whose hands have less flexibility than a month ago, knuckles are swelling, and the swelling is increasing with time, sometimes scratch and rub my eyes, big blisters, disgusting rash on back and arms With welts, conjunctivitis, joint pain in his fingers/the join pain is progressive pain started on the outside fingers of the Pinkie and index fingers and then moved inside to the other fingers/joint pain in his hands is slowly getting worse and patchy rashes on his back shoulders, buttock. and arms/patchy rash is in his scalp and beard/rash all over his back and shoulders/disgusting rash on back and arms welts while being treated with PFIZER BIONTECH COVID.19 VACCINE). In 2022 the patient taking DUPILUMAB.  PRODUCT NOS and PFIZER BIONTECH COVID-i9 VACCINE (TOZINA MERAN) (with an unknown dose, route, frequency, Indication, batch number). Information on batch number was requested. First lime product used was no. In 2022 the patient developed a non-serious events joint pain in his hands is slowly gelling worse (arthralgia) and symptoms condition aggravated and are very itchy eyes, that arc getting progressively worse (unknown latency) following the first dose of (PFIZER BIONTECH COVID-19 VACCINE), PRODUCT NOS. It was reported the caller staled that Within 2 days of starting Dupixent, his rash completely disappeared. He had the rash since he was 15 years old. At first, he had no side effects of Dupixcnt. Then about 1 to 2 months after starting, he began 10 experience joint pain in his fingers. He believes the join pain is progressive, He has been on Dupixcnt now for 3 months and the joint pain in his hands is slowly getting worse. The pain started on the outside fingers of the pinkie and index fingers and then moved inside to the other fingers. Both hands are affected. His hands have less flexibility than a month ago, His knuckles are swelling, and the swelling is increasing with time. He is also experiencing patchy rashes on his back, shoulders, buttock, and arms. Some of the patchy rash is in his scalp and beard. He has food allergies, and since being on Dupixent, he has not been as strict with avoiding foods 10 which he is allergic. He believes that the patchy rashes might be due to exposing himself to such foods, but he is not certain. He ate eggs last night to which he is allergic, and today little symptoms in his scalp hair and beard. The patchy areas might last a day or two and then go away. He can expose himself to his allergic foods now on Dupixent without becoming as sick as he would have in the past. However, he seems to still be having some effect from the foods, due to these patchy rashes. He has a gluten allergy, and gluten is one of the things he is been consuming more of lately. He is also experiencing eye side effects of Dupixent. He has visited the eye doctor twice. The symptoms are very itchy eyes, that are getting progressively worse. The first thing tried was an antibiotic eye drop for 10 days for conjunctivitis. His eyes improved, but the symptoms did not go away entirely. After that, he was given an antibiotic eye ointment (neomycin and doxamethasone per the AE (adverse event) Intake consultant) to use every other day. The day that he uses it, the ointment helps. But the day he does not use the ointment, the symptoms return, although to a lesser degree. He says that to him, the eye effects do not seem like a true side effect. Instead, he believes the eye effects occur because one part of the immune system is shut down by Dupixent, and the eye effects are then allowed to come out as another way for the immune system to express Itself. No further information reported or gathered because the caller already spoke with AE Intake. The caller is currently 73 years old. He stated that 3 years ago he had surgery on his hand. At that time, he received an antibiotic called mycin something. He said that the name sounded sort of like erythromycin, but it was not erythromycin. The antibiotic caused him to have a rash all over his back and shoulders, with big blisters, The caller stated that after receiving a Pfizer Covid-19 booster shot, he experienced a disgusting rash on his back and arms With welts. Corrective treatment antibiotic eye and antibiotic eye ointment (neomycin and dexamethasone) was received for the events (are very itchy eyes, that arc getting progressively worse, conjunctivitis, condition aggravated).   Reporter causality with dupilumab not reported for all the events and with product nos Related for rash and blisters. Company causality with dupliumab Not Reportable for blisters, urticaria, Superficial injury of eye, Reportable for rest all the events and with product nos reportable for rash and blisters and not reportable for rest all the events   The information on the batch/lot number for BNT162b2 has been requested and will be submitted if and when received.