Heart palpitations; fainting; cold sweat; beats in singles and triplets; My left ankle was swollen without pain; This is a spontaneous report from a contactable consumer (patient). A 35-year-old non-pregnant female patient received the second dose of BNT162B2 (PFIZER-BIONTECH COVID-19 MRNA VACCINE; solution for injection; Lot #: Unknown) intramuscularly on 01May2021 at 13:15 (at the age of 35-years-old) as a single dose in the left arm for COVID-19 immunisation. Medical history included Lyme disease from an unspecified date and unspecified if ongoing (at 12 years old and was treated with amoxicillin and tested negative for Lyme's in 2019), prior TBI (traumatic brain injury) on 20Nov2005 and ongoing that resulted in concussion, long term change in information processing and memory, ganglion cysts from 2018 and ongoing (in hands, benign, intermittent with flare ups) and ocular migraine from May2018 and ongoing (triggered by anxiety and pressure in occipital lobe). Prior to vaccination, the patient was not diagnosed with COVID-19. Concomitant medications (received within 2 weeks of vaccination) included indomethacin (INDOMETACIN) orally taken for brain inflammation from 24Apr2021 and ongoing at 50mg, 2x/day, as needed; diphenhydramine hydrocholoride (BENADRYL) orally taken for sleep aid from an unspecified date and ongoing at 25mg and fexofenadine hydrochloride orally taken for tree grass allergy from 01Feb2021 and ongoing. The patient did not receive any other vaccines within 4 weeks prior to the COVID-19 vaccine. The patient previously received hydrocortisone for an unspecified indication on unspecified dates and experienced inflammation (as an adolescent I had inflammatory response to hydrocortisone topical cream). The patient previously received the first dose of BNT162B2 (PFIZER-BIONTECH COVID-19 MRNA VACCINE; solution for injection; Lot #: EW0162) intramuscularly on 10Apr2021 at 11:05 (at the age of 35-years-old) as a single dose in the left arm for COVID-19 immunisation and experienced my right great toe had sudden onset of chronic neuropathy (with sensation as if a cord was tied tightly around it and that sensation has not gone away and has stayed constant). On 01May2021 at 16:00 the patient experienced my left ankle was swollen without pain, on 02May2021 at 03:00 the patient experienced heart palpitations and on 02May2021 at an unspecified time the patient experienced fainting, cold sweat and beats in singles and triplets. Heart palpitations was reported as serious for life-threatening. The course of events was reported as follows: "after the second shot on the same evening, my left ankle was swollen without pain, which was not a normal condition for me and I did not recall any recent bumps or twists which would have caused it. I plan to seek treatment if conditions worsen and/or after the weekend." The patient reported that she experienced palpitations and there was no time to decide to go to the ER. The event was over after 5 minutes. The patient stated that there was no consistent pattern, there was a return to normal heartbeats after 5 minutes. The patient reported a 5 minutes duration of fainting, cold sweat, beat in single and triplets. The patient stated that this was an informational report to aid us in documenting any patterns we might see in patients. The patient reported that treatment was not received for the events. The patient underwent lab tests and procedures that included: x-ray on 05May2021 which was negative (left ankle, sprain, no fractures). The clinical outcomes of the events heart palpitations, fainting, cold sweat and beats in singles and triplets were recovered/resolved on 02May2021; my left ankle was swollen without pain was not recovered/not resolved. Since the vaccination, the patient had not been tested for COVID-19.  No follow-up attempts are needed; information about lot/batch number cannot be obtained.