Severe depression; I had anxiety and depression for most of my life; this is the depression like I never experienced before; My depression has daily getting significantly worse over the past years; Lack of motivation; I spend rest of my time at bed just because I have no motivation to get up and do anything.; got to a point where I could no longer function and wasn't able to like to get out the bed to work; Itchy Vaccine Injury; Vaccine site injury; This is a spontaneous report received from a contactable reporter(s) (Nurse). The reporter is the patient.  A 40-year-old female patient received BNT162b2 (BNT162B2), on 17Apr2021 as dose 1 , single (Lot number: ER8731), on 08May2021 as dose 2 , single (Lot number: ER8736) and on 22Jan2022 as dose 3 (booster), single (Lot number: FL3209) at the age of 40 years for covid-19 immunisation. The patient's relevant medical history included: "Fibromyalgia" (unspecified if ongoing), notes: Pregabalin 150 mg capsule, one capsule twice a day. Taking Cyclobenzaprine 10 mg tablet at bed time; "Chronic headaches" (unspecified if ongoing), notes: Chronic headaches; "Migraine" (ongoing), notes: Migraine; "Asthma" (ongoing), notes: Asthma, Taking Montelukast. Taking 10 mg tablet once a day.; "GERD" (ongoing), notes: GERD, Taking Pantoprazole 40 mg tablet twice a day.; "Depression" (ongoing), notes: depression has daily getting significantly worse over the past years; "anxiety" (ongoing), notes: I had anxiety and depression for most of my life.; "difficulty concentrating." (unspecified if ongoing), notes: I also have difficulty concentrating.; "Lack of motivation" (unspecified if ongoing), notes: I spend rest of my time at bed just because I have no motivation to get up and do anything. Concomitant medication(s) included: TRINTELLIX taken for depression; ALPRAZOLAM ER; FLUVOXAMINE, start date: 23Mar2022; VENLAFAXINE XR; TOPIRAMATE taken for migraine; MONTELUKAST taken for asthma; CETRIZINE taken for hypersensitivity; PREGABALIN taken for fibromyalgia; CYCLOBENZAPRINE taken for fibromyalgia; PANTOPRAZOLE taken for gastrooesophageal reflux disease.  The following information was reported: DEPRESSION (disability, medically significant), outcome "unknown", described as "Severe depression; I had anxiety and depression for most of my life; this is the depression like I never experienced before; My depression has daily getting significantly worse over the past years"; APATHY (non-serious), outcome "unknown", described as "Lack of motivation; I spend rest of my time at bed just because I have no motivation to get up and do anything."; LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (non-serious), outcome "unknown", described as "got to a point where I could no longer function and wasn't able to like to get out the bed to work"; VACCINATION SITE PRURITUS (non-serious), outcome "unknown", described as "Itchy Vaccine Injury"; VACCINATION SITE INJURY (non-serious), outcome "unknown", described as "Vaccine site injury". Therapeutic measures were taken as a result of depression, apathy.  Clinical course: Pfizer Employee stated, "patient have been experiencing severe depression. patient also have difficulty concentrating, lack of motivation and when patient saw Psychiatrist earlier that week she said she believe it the itchy vaccine injury from the COVID Vaccine. Yes, that she told me." When paraphrased the concern, Pfizer employee stated, "Yes, patient had anxiety and depression for most of my life but this is the depression like never experienced before." Pfizer employee stated, "It's hard to pin point a specific date. patient depression has been getting significantly worse over the past years (Further clarifications unknown). patient got to a point where could no longer function and wasn't able to like to get out the bed to work. patient would say this month, would say more got bad just bad but it is getting significantly worse over the past year. When medication for depression and anxiety, Pfizer employee stated, "A lot of medication for that. I am on, I before my, before my depression I was still taking Trintellix 20 mg, yes it is for depression. I am currently taking it but the dosage was changed so I was previously taking it at 20 mg, once a day and then I can tell you when it was changed, on 26Apr2022 my psychiatrist changes it to 10 mg, once a day. Currently, I am taking 10mg. I take Alprazolam, extended release, that's the 1 mg tablet. I take that twice a day. Before that it was 20. Currently I am only taking once a day. She put me on something, she added something else and then she decrease the Trintellix. I haven't told you about that, so the new medicine that she gave me is called Fluvoxamine, so on 23Mar, I started taking at 50 mg once a day on 23Mar2022 and then on April 26Apr, when she decreases my Trintellix, she doubled the dosage of Fluvoxamine to 50 mg twice a day and then when I saw her on Tuesday 24May, she increase the Fluvoxamine again to taking a 100 mg in the morning and 50 mg at night. Yeah, that started on the 24th. I also had Alprazolam, that is immediate release, it is 0.5 mg it's a tablet and I just as needed for break through anxiety. Yes, that's the immediate release as I take it as needed as 25 mg (Not clarified) and then I have the extended release as I told you about earlier but I take 0.5. Venlafaxine Extended Release. If you want I can give you information, I take a lot of medication, Topiramate Extended Release (Captured as provided) 100mg, 100 mg capsule, one capsule for twice daily and that's for my chronic migraine." Pfizer employee stated, "Yes, I am on out on medically 'leave' usually dealing short time disability (Further clarification unknown hence event captured as per verbatim). I have right now. No, Not so much feeling anxiety is more, it's the depression that's causing the problem. I have some good day mostly bad days. I spend rest of my time in bed just because I have no motivation to get up and do anything." When probed for the treatment, Pfizer employee stated, "Not other than what I early told you that my Psychiatrist start reaching my medication around. She told me when I saw her on Tuesday that she is expecting or she has heard that there should be release of information regarding how she she treat those with vaccine injuries and long COVID and she was waiting to see what that recommendation is before she tell me to any further coarse of treatment."  No follow-up attempts are possible. No further information is expected.