Erythema Nodosum; Rash/ lumps on both legs knee to ankle, swollen; Rash/ lumps on both legs knee to ankle, swollen; Rash/ lumps on both legs knee to ankle, swollen; sick; made me gain over 30 lbs; water retention and swelling; Depressive symptoms; nausea; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP). The reporter is the patient.  A 70-year-old female patient (not pregnant) received BNT162b2 (BNT162B2), on 15Dec2021 at 10:30 as dose 3 (booster), single (Lot number: EN6200) at the age of 70 years, in left arm for covid-19 immunisation. The patient's relevant medical history included: "Recovered from breast cancer in Aug 2019 triple negative stage 3", stop date: Aug2019, notes: Recovered from breast cancer in Aug2019 triple negative stage 3. Concomitant medication(s) included: LEVOTHYROXINE. Past drug history included: Hydrocodone, reaction(s): "Known allergies: Hydrocodone", notes: Known allergies: Hydrocodone. Vaccination history included: BNT162b2 (DOSE 1, SINGLE, lot number: EN5318, Previous dose administration time: 08:00, Previous dose number 1, Previous dose vaccine location: Left arm.), administration date: 07Feb2021, when the patient was 69-year-old, for COVID-19 immunization; BNT162b2 (DOSE 2, SINGLE, lot number: EN5318, Previous dose administration time: 08:00, dose vaccine location: Left arm.), administration date: 28Feb2021, when the patient was 69-year-old, for COVID-19 immunization. The following information was reported: DEPRESSIVE SYMPTOM (non-serious) with onset 17Dec2021 at 08:00, outcome "not recovered", described as "Depressive symptoms"; ERYTHEMA NODOSUM (non-serious) with onset 17Dec2021 at 08:00, outcome "not recovered"; RASH (non-serious), LIMB MASS (non-serious), PERIPHERAL SWELLING (non-serious) all with onset 17Dec2021 at 08:00, outcome "not recovered" and all described as "Rash/ lumps on both legs knee to ankle, swollen"; WEIGHT INCREASED (non-serious) with onset 17Dec2021 at 08:00, outcome "not recovered", described as "made me gain over 30 lbs"; NAUSEA (non-serious) with onset 17Dec2021 at 08:00, outcome "not recovered"; ILLNESS (non-serious) with onset 17Dec2021 at 08:00, outcome "not recovered", described as "sick"; FLUID RETENTION (non-serious) with onset 17Dec2021 at 08:00, outcome "not recovered", described as "water retention and swelling". The events "erythema nodosum", "rash/ lumps on both legs knee to ankle, swollen", "sick", "made me gain over 30 lbs", "water retention and swelling", "depressive symptoms" and "nausea" required physician office visit and emergency room visit. Relevant laboratory tests and procedures are available in the appropriate section. Therapeutic measures were taken as a result of erythema nodosum, rash, limb mass, peripheral swelling, illness, weight increased, fluid retention, depressive symptom, nausea.  Additional Information: Patient reported that she had Erythema Nodosum. Rash/ lumps on both legs knee to ankle, swollen, chest X-rays, blood test, TB test, checked everything Medication has made her sick and made her gain over 30 lbs causing other issues due to water retention and swelling. Depressive symptoms, nausea, Patient received treatment Ultrasound, prednisone, dapsone, duloxetine, hydro, no COVID prior to the vaccination, no other vaccine in four weeks, COVID tested post vaccination was negative.