Felt like sleeping.Sunday could not get out of bed; Did not feel well; Toes are red and purple; Severe reaction to the vaccine; Small blisters on her toes; Felt weak, tired; Toes were swollen; Toes hurt and they were pulsating;Felt a great pressure in her feet; Toes were swollen and red.; Body discomfort; Hand pain; Pain in the neck, in the occipital part.; She could not bend her fingers; Could not open her mouth; Felt pain and rigidness in the temporo maxillary joint; Pain that spread into her ear; Injection arm pain; Muscle pain; Tiredness; This spontaneous case was reported by a consumer (subsequently medically confirmed) and describes the occurrence of DISCOMFORT (Body discomfort), PAIN IN EXTREMITY (Hand pain), NECK PAIN (Pain in the neck, in the occipital part.), MUSCULOSKELETAL STIFFNESS (She could not bend her fingers) and TRISMUS (Could not open her mouth) in a 59-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch no. 031B21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     The patient's past medical history included Migraine and Herpes zoster.    On 20-Apr-2021, the patient received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 23-Mar-2021, the patient experienced FATIGUE (Tiredness). On 20-Apr-2021, the patient experienced DISCOMFORT (Body discomfort), PAIN IN EXTREMITY (Hand pain), NECK PAIN (Pain in the neck, in the occipital part.), MUSCULOSKELETAL STIFFNESS (She could not bend her fingers), TRISMUS (Could not open her mouth), MUSCLE RIGIDITY (Felt pain and rigidness in the temporo maxillary joint), EAR PAIN (Pain that spread into her ear), INJECTION SITE PAIN (Injection arm pain) and MYALGIA (Muscle pain). On 25-Apr-2021, the patient experienced BEDRIDDEN (Felt like sleeping.Sunday could not get out of bed), MALAISE (Did not feel well), SKIN DISCOLOURATION (Toes are red and purple), VACCINATION COMPLICATION (Severe reaction to the vaccine), BLISTER (Small blisters on her toes), ASTHENIA (Felt weak, tired), SWELLING (Toes were swollen), LIMB DISCOMFORT (Toes hurt and they were pulsating;Felt a great pressure in her feet) and ERYTHEMA (Toes were swollen and red.). At the time of the report, DISCOMFORT (Body discomfort), PAIN IN EXTREMITY (Hand pain), NECK PAIN (Pain in the neck, in the occipital part.), MUSCULOSKELETAL STIFFNESS (She could not bend her fingers), TRISMUS (Could not open her mouth), MUSCLE RIGIDITY (Felt pain and rigidness in the temporo maxillary joint), EAR PAIN (Pain that spread into her ear), INJECTION SITE PAIN (Injection arm pain), FATIGUE (Tiredness), MYALGIA (Muscle pain), BEDRIDDEN (Felt like sleeping.Sunday could not get out of bed), MALAISE (Did not feel well), SKIN DISCOLOURATION (Toes are red and purple), VACCINATION COMPLICATION (Severe reaction to the vaccine), BLISTER (Small blisters on her toes), ASTHENIA (Felt weak, tired), SWELLING (Toes were swollen), LIMB DISCOMFORT (Toes hurt and they were pulsating;Felt a great pressure in her feet) and ERYTHEMA (Toes were swollen and red.) outcome was unknown.        For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown), the reporter did not provide any causality assessments.   No concomitant medications were provided.  Treatment provided was Tylenol,  injection of dexamethasone and prednisone   This case was linked to US-MODERNATX, INC.-MOD-2021-086246 (E2B Linked Report).   Most recent FOLLOW-UP information incorporated above includes: On 28-Apr-2021: Follow up received on 28 Apr 2021 :  Added Medical History Herpes zoster (shingles). Added events felt weak, tired; felt like sleeping. Sunday could not get out of bed;Her toes hurt and they were pulsating;felt a great pressure in her feet;toes were swollen and red;Did not feel well;small blisters on her toes; Toes are red and purple; severe reaction to the vaccine all events outcome unknown.; Sender's Comments:  US-MODERNATX, INC.-MOD-2021-086246: