This case was reported by a consumer (patient) and described the occurrence of allergic reaction in a 69-year-old female patient who received ADVAIR multi dose powder inhaler for chronic obstructive pulmonary disease. A physician or other health care professional has not verified this report. The patient's past medical history included eye surgery, gallbladder exeresis, hernia operation, knee replacement, leg surgery, open heart surgery, removal of appendix, resection part of bowel, heart trouble, and stent. Concurrent medical conditions included vitamin D deficiency, asthma and pockets in cornea. Co-suspect medication included VENTOLIN and Amoxicillin. Concurrent medications included ANORO ELLIPTA, REFRESH, Albuterol nebulizer, IMDUR, Potassium chloride, Freestyle Test Strips, NITROSTAT, Fenofibrate, CRESTOR, MEDROL, ZOFRAN, RANEXA, HUMALOG, Calcium, PEPCID, Fish oil, Trazodone, Vitamin E, Vitamin D, ABILIFY, ATIVAN, SEROQUEL, Herbal supplement, LORTAB, Aspirin, Eye drops and RESTASIS. On an unknown date, the patient started ADVAIR (inhaled route) at 1 puff (s) twice per day. At an unknown time after starting ADVAIR, the patient experienced allergic reaction, trouble breathing, yeast infection, blurred vision, bad general health, oral thrush, jaw tightness, swollen tongue and throat closed. The patient was hospitalised. The patient reported that she had been on ADVAIR for a long time before she started to experience oral thrush. The patient reported that the first incident was in February 2013 and that she was in the hospital for quite a while and she refused to take ADVAIR. Patient stated that when she would get thrush she would treat with clotrimazole and it would take quite a few weeks to get better. The patient reported that she is very susceptible to any antibiotic or steroid and about 4 antibiotics have caused her to have oral thrush. The patient stated she used to take amoxicillin for diverticulitis. It was reported by the patient that recently while taking ADVAIR and VENTOLIN she took amoxicillin for a UTI and the amoxicillin caused oral thrush. The amoxicillin also caused a yeast infection under the folds of her skin near her Depends so her doctor told her to stop the amoxicillin until these clear up. The patient reported that she was using NYSTOP for the yeast infection. The patient reported that she has taken clotrimazole for some time to treat oral thrush but she had an allergic reaction to the clotrimazole "last Sunday and was hospitalized until Monday morning" (end of July 2014). The patient reported that she experienced trouble breathing (which did not get better after breathing treatments), her jaw tightened, her tongue swelled, and her throat closed. The patient was supposed to have a catheterization but since "her body was in such bad shape" it had been rescheduled. The patient reported that she switched from SPIRIVA to ANORO about 5 months ago. The SPIRIVA was fine but ANORO seems to work better for her. The patient also mentioned having blurry vision from applying REFRESH eye gel that has not yet cleared up. The patient was treated with clotrimazole and NYSTOP powder. Treatment with ADVAIR was discontinued. At the time of reporting, the events were unresolved. The patient started an unknown strength of ADVAIR years ago and VENTOLIN a couple years ago. She eventually stopped ADVAIR because it kept giving her oral thrush. Follow up was received on 08 August 2014. It was reported by the patient that she is currently on IMDUR, Potassium chloride, NITROSTAT, ANORO, Fenofibrate, CRESTOR, MEDROL, RANEXA, Albuterol Nebulizer, HUMALOG in insulin pump, PEPCID, Trazodone, ABILIFY, ATIVAN, SEROQUEL, LORTAB (3.75mg), Replenish (NAC), low dose aspirin, Vitamin D, REFRESH eye drops and gel, RESTASIS, and OPTIVE REFRESH eye drops. Patient reported that she had previously used PROAIR, she was in Hospice twice for COPD and she used oxygen for ten years and has been off of the oxygen for over a year. In 2001 patient had open heart surgery. Patient also reported she had 98% blockage in main heart blood vessel. Patient stated that a few years later she had more heart surgery and had a stent put in around 2007. It was reported by the patient that both parents died young of heart attacks. Patient stated she stop ADVAIR last year. Patient reported she has had ten leg surgeries, which included four knee replacements surgeries and three leaky veins repaired. Patient reported she woke up and used her VENTOLIN at 4am and then she went to the emergency room between 11:30 and noon. Patient stated she started having chest pains on Wednesday August 6, 2014. Patient reported that the chest pains were severe and "as going to her jaw" and the worst chest pains she had ever had. Patient reported she started NITROSTAT and that got rid of some of the pain but not all of it. Patient is currently 70 years old. It was reported by the patient that VENTOLIN helps her and makes the "heaviest" in her chest go away. Patient stated that VENTOLIN did not cause the chest pain. The outcome of the events indigestion and chest pain were currently resolved. Follow-up information was received on 02 September 2014 via patient. Additional suspect vaccines included Influenza vaccine unspecified and Pneumonia vaccine (Non-GSK). Concomitant medications included other medications but did not provide the names. Additional medical conditions included "has a ton of allergies", lymphedema in her left arm and a history of cancer. The patient received Influenza vaccine unspecified and Pneumonia vaccine (Non-GSK) on an unspecified date in December 2013 in the right arm. In December 2013 the patient experienced her arm broke out and reaction. The patient reported she thought her arm broke out because she got both the flu shot and pneumonia shot in the same arm in December 2013. She stated her doctor was at the pharmacy when she had the reaction and she used a cream to treat the reaction. The patient also reported this morning (02 Sep 2014) she woke up with the flu. She was going to get the flu shot today but she couldn't because she was sick. She stated she hasn't had the flu shot this year. At the time of this report the breaking out on arms and injection site reaction were resolved. The outcome of sick and influenza was unresolved.