Adverse reaction of both supraclavicular nodes. Left node is larger than right / The size of swelling has not changed over the last 12 -14 weeks; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP). The reporter is the patient.  A 62 year-old male patient received bnt162b2 (BNT162B2), administered in arm left, administration date 14Apr2021 13:30 (Lot number: EP7533) at the age of 62 years as dose 2, single for covid-19 immunisation. Relevant medical history included: "High blood pressure" (unspecified if ongoing), notes: High blood pressure controlled by medication; "Anxiety" (unspecified if ongoing), notes: anxiety controlled by medication. Concomitant medication(s) included: AMLODIPINE [AMLODIPINE BESILATE]; SERTRALINE [SERTRALINE HYDROCHLORIDE]; LOSARTAN. Vaccination history included: Bnt162b2 (product=COVID 19, brand=Pfizer ,, lot number=EP7534,, administration time=10:30 AM,, dose number=1,, vaccine location=Left arm), administration date: 22Mar2021, when the patient was 62 years old, for Covid-19 immunization, reaction(s): "swelling in the area of both left and right supraclavicular nodes".  The following information was reported: LYMPHADENOPATHY (non-serious) with onset 14Apr2021 13:00, outcome "not recovered", described as "Adverse reaction of both supraclavicular nodes. Left node is larger than right / The size of swelling has not changed over the last 12 -14 weeks". The event "adverse reaction of both supraclavicular nodes. left node is larger than right / the size of swelling has not changed over the last 12 -14 weeks" was evaluated at the physician office visit. Relevant laboratory tests and procedures are available in the appropriate section. Therapeutic measures were taken as a result of lymphadenopathy.  Additional information: Facility type vaccine was reported as Other. Patient had not received any other vaccine in four weeks. The patient had no COVID prior vaccination. Patient had no known allergies. Post vaccination the patient was tested for COVID and Nasal Swab Rapid test was performed on 15Aug2021 which result was Negative. Adverse event: reporter stated that adverse reaction of both supraclavicular nodes. Left node was larger than right. The size of swelling has not changed over the last 12-14 weeks. No pain ever associated over this time period. Ultrasound performed 23Aug2021 to rule out possible supraclavicular lymphoma. Also, a lung x-ray and blood work. No report on blood work yet but other tests proved to be unremarkable. Both his doctor and himself have concurred due to timing of episode that this was an adverse reaction to the vaccine. He believed this was from the 2nd vaccine however stated that his first shot was given to him unusually high on his arm. The swelling being in the supraclavicular area was not obvious to me at first as it presented itself as more of a puffiness than a hard lump which would me more noticeable in the upper neck. His concern was the duration of the swelling. He was prescribed Amoxicillin and Prednisone yesterday to possibly help his situation. The adverse events resulted in doctor or other healthcare professional office/clinic visit.   Follow-up attempts are completed. No further information is expected.