Swelling of the veins; Chest tightness; Shortness of breath; Face starts to flush; Acute urticaria/urticaria; Full body rash/rash came back with more severity than before/rashes appear at random places in his body at random times/rashes last around 60 minutes and then disappear; Red blotches/blotches in his throat, face, armpits and legs; Itchy rash began to grow on his groin and arm pits/rash incredibly itching; This spontaneous case was reported by an other health care professional and describes the occurrence of RASH PRURITIC (Itchy rash began to grow on his groin and arm pits/rash incredibly itching), VARICOSE VEIN (Swelling of the veins), CHEST DISCOMFORT (Chest tightness), DYSPNOEA (Shortness of breath) and RASH MACULAR (Red blotches/blotches in his throat, face, armpits and legs) in a 40-year-old male patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 030L20A and 026L20A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     The patient's past medical history included Joint injury. Concomitant products included MULTIVITAMINS [VITAMINS NOS] for an unknown indication.   On 08-Jan-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 03-Feb-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 09-Nov-2021, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 19-Nov-2021, the patient experienced RASH PRURITIC (Itchy rash began to grow on his groin and arm pits/rash incredibly itching). On 22-Nov-2021, the patient experienced RASH MACULAR (Red blotches/blotches in his throat, face, armpits and legs) and RASH (Full body rash/rash came back with more severity than before/rashes appear at random places in his body at random times/rashes last around 60 minutes and then disappear). On an unknown date, the patient experienced VARICOSE VEIN (Swelling of the veins), CHEST DISCOMFORT (Chest tightness), DYSPNOEA (Shortness of breath) and FLUSHING (Face starts to flush). an unknown date, the patient experienced URTICARIA (Acute urticaria/urticaria). The patient was treated with PREDNISONE for Adverse event, at an unspecified dose and frequency. At the time of the report, RASH PRURITIC (Itchy rash began to grow on his groin and arm pits/rash incredibly itching), VARICOSE VEIN (Swelling of the veins), CHEST DISCOMFORT (Chest tightness), DYSPNOEA (Shortness of breath), RASH MACULAR (Red blotches/blotches in his throat, face, armpits and legs), FLUSHING (Face starts to flush) and URTICARIA (Acute urticaria/urticaria) outcome was unknown and RASH (Full body rash/rash came back with more severity than before/rashes appear at random places in his body at random times/rashes last around 60 minutes and then disappear) had resolved.        For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown), the reporter did not provide any causality assessments.   Concomitant medication included Joint Supplement (unspecified).  Patient had got a blood panel yesterday, but he was still waiting the results. Today, 30-Nov-2021, patient had a follow up with his primary care physician.  Treatment information included antihistamine (unspecified).  Company Comment - This case concerns a 40 year old male patient with no relevant medical history, who experienced the non-serious unexpected event of rash pruritic, varicose vein, chest discomfort, dyspnoea and rash macular, flushing and urticaria, and the expected event of rash. The event rash pruritic, occurred approximately 10 days after the third dose of mRNA-1273 vaccine. The events rash macular, rash occurred approximately 13 days after the third dose of mRNA-1273 vaccine. The events varicose vein, chest discomfort, dyspnoea, flushing and urticaria occurred on an unknown date after the third dose of mRNA-1273 vaccine. The rechallenge was not applicable as this is the third dose. The benefit-risk relationship of the mRNA-1273 vaccine is not affected by this report.   This case was linked to MOD-2021-402794 (Patient Link).; Sender's Comments: This case concerns a 40 year old male patient with no relevant medical history, who experienced the non-serious unexpected event of rash pruritic, varicose vein, chest discomfort, dyspnoea and rash macular, flushing and urticaria, and the expected event of rash. The event rash pruritic, occurred approximately 10 days after the third dose of mRNA-1273 vaccine. The events rash macular, rash occurred approximately 13 days after the third dose of mRNA-1273 vaccine. The events varicose vein, chest discomfort, dyspnoea, flushing and urticaria occurred on an unknown date after the third dose of mRNA-1273 vaccine.The rechallenge was not applicable as this is the third dose. The benefit-risk relationship of the mRNA-1273 vaccine is not affected by this report.