essential hypertension; injection site was hard; vaccination site rash; vaccination site swelling; This spontaneous case was reported by a consumer and describes the occurrence of ESSENTIAL HYPERTENSION (essential hypertension), INJECTION SITE INDURATION (injection site was hard), VACCINATION SITE RASH (vaccination site rash) and VACCINATION SITE SWELLING (vaccination site swelling) in a 68-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 001A21A and 012M20A) for COVID-19 vaccination.     Concurrent medical conditions included Pollen allergy, Penicillin allergy and Drug allergy (cefdinir: itching). Concomitant products included CETIRIZINE for Allergy, METOPROLOL SUCCINATE (TOPROL XL) from 12-Feb-2021 to 12-Feb-2021 for an unknown indication.   On 28-Jan-2021 at 11:30 AM, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 25-Feb-2021 at 11:30 AM, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. On 07-Mar-2021, the patient experienced VACCINATION SITE RASH (vaccination site rash). 07-Mar-2021, the patient experienced VACCINATION SITE SWELLING (vaccination site swelling). On 07-Mar-2021 at 8:00 AM, the patient experienced INJECTION SITE INDURATION (injection site was hard). On an unknown date, the patient experienced ESSENTIAL HYPERTENSION (essential hypertension). The patient was treated with AMLODIPINE for Blood pressure, at a dose of 2.5 mg. At the time of the report, ESSENTIAL HYPERTENSION (essential hypertension) had not resolved and INJECTION SITE INDURATION (injection site was hard), VACCINATION SITE RASH (vaccination site rash) and VACCINATION SITE SWELLING (vaccination site swelling) outcome was unknown.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On 26-Feb-2021, Blood pressure measurement: 139/81 9am, 156/73 noon and 137/77 evening. On 26-Feb-2021, Heart rate: 82 9am, 81 noon and 80 evening. On 27-Feb-2021, Blood pressure measurement: 126/73 4:30pm. On 27-Feb-2021, Heart rate: 71 4:30pm and 69 9:30pm. On 28-Feb-2021, Blood pressure measurement: 119/77 9am and 124/75 8pm. On 28-Feb-2021, Heart rate: 79 9am and 73 8pm. On 01-Mar-2021, Blood pressure measurement: 139/70 9am, 131/69 1:30pm and 131/75 10pm. On 01-Mar-2021, Heart rate: 74 9am, 74 1:30pm and 66 10pm. On 03-Mar-2021, Blood pressure measurement: 144/83 noon and 158/77 5pm. On 03-Mar-2021, Heart rate: 73 noon and 79 5pm. On 05-Mar-2021, Blood pressure measurement: 130/77 4pm. On 05-Mar-2021, Heart rate: 86 4pm. On 07-Mar-2021, Blood pressure measurement: 143/80 5:30pm. On 07-Mar-2021, Heart rate: 75 5:30pm. On 09-Mar-2021, Blood pressure measurement: 147/83 6pm. On 09-Mar-2021, Heart rate: 75 6pm. On 10-Mar-2021, Blood pressure measurement: 122/72 noon "normal per MD". On 10-Mar-2021, Heart rate: 77 noon. On 11-Mar-2021, Blood pressure measurement: 119/73 2pm "normal per MD". On 11-Mar-2021, Heart rate: 83 2pm. On 12-Mar-2021, Blood creatinine: 0.91 (Inconclusive) 0.91 mg/dl. On 12-Mar-2021, Blood pressure measurement: 118/68 right arm, sitting. On 12-Mar-2021, Body temperature: 97.9 f (Inconclusive) Temporal. On 12-Mar-2021, Glomerular filtration rate: 53.60. On 12-Mar-2021, Heart rate: 89 bpm finger clip, sitting. On 12-Mar-2021, Oxygen saturation: 97 % (room air).         Patient only took one tablet of metoprolol ER and then it made her sick. She went to the hospital because she "could not move off the couch" and she did not take another pill. Her cardiologist discontinued the Metoprolol ER from previous ER visit and initiated amlodipine 2.5 mg once daily as directed to control blood pressure on 12Mar2021. Patient  was diagnosed with essential hypertension on 12MAr2021.   This case was linked to MOD-2021-027450 (Patient Link).