Gets the flu vaccine and gets the flu / Every flu shot she received, she has gotten the flu/Suspected vaccination failure; macular degeneration diagnosed about 3-5 years ago; Gets the flu vaccine and gets the flu; This case was reported by a nurse via other manufacturer and described the occurrence of suspected vaccination failure in a 81-year-old female patient who received Flu unspecified (Flu vaccine) for prophylaxis.   The patient's past medical history included anaphylactic reaction (to a metapower bar). Previously administered products included Shingles vaccine with an associated reaction of herpes zoster (received in 2014 and had mild case of shingles 2 to 3 weeks later of shingles vaccination) and Flu vaccine with an associated reaction of influenza (received in 2015, refer case US2021AMR116381). Concurrent medical conditions included atrial tachycardia, thyroid hormones decreased (seems like she had forever), blood cholesterol increased (just beyond normal, had for years), latex allergy (since the 1980's), fruit allergy (Banana, avocado, and kiwi allergy and the patient stated all were interrelated because they were cousins to the rubber tree plant and also healthcare personnel allergic to latex could and might develop a cross allergy to psyllium which was metamucil) and herbal allergy (Psyllium allergy, the patient had an anaphylactic reaction to a metapower bar in 2015. About 7 minutes after eating the bar, she went into a severe reaction and ended up in the emergency room and stayed overnight.). Concomitant products included metoprolol (Metoprolol Er), levothyroxine sodium (Synthroid), acetylsalicylic acid (Aspirin (Baby)), calcium + magnesium (Calcium With Magnesium) and chondroitin + glucosamine (Glucosamine Chondroitin).   On an unknown date, the patient received Flu vaccine. On an unknown date, unknown after receiving Flu vaccine, the patient experienced vaccination failure (serious criteria GSK medically significant), macular degeneration (serious criteria GSK medically significant) and influenza. The patient was treated with ascorbic acid + copper + retinol + tocopherol + zinc (Ocuvite Preservision) and ascorbic acid (Vitamin C). Rechallenge with Flu vaccine was positive. On an unknown date, the outcome of the vaccination failure and influenza were unknown and the outcome of the macular degeneration was not recovered/not resolved.   It was unknown if the reporter considered the vaccination failure, macular degeneration and influenza to be related to Flu vaccine.  Additional details were reported as follows: The registered nurse reported this case for herself. The age at vaccination was not reported but could be 75 or 76 years. The patient was taking Multivitamin (unspecified) since 1995 or 1996, about 25 years for general health and glucosamine chondroitin since late 1990s, about 20 years for joint health. The patient started Synthroid about 15 years ago and taking Calcium with Magnesium as it had calcium citrate from a long time, 5 to 10 years, she did not really remember the exact date In January 2016, the patient was taking baby aspirin as cardiologist thought it would be a good idea. In 2016, the patient received flu vaccine and got the flu. Less than a year after receiving Flu vaccine, the patient was diagnosed with macular degeneration (age related) about 3 to 5 years ago from reporting date and the physician prescribed Ocuvite PreserVision along with Vitamin C as eye doctor though it was a good idea to take together and the patient was taking there for about 3 years and stated macular degeneration had not changed or gotten worse in 3 years. The patient stated that she would had lost her job if she did not take vaccine. It had been 5 to 10 years before that, and another 5 to 10 years before that.  The patient stated she stays away from the flu shot. The patient stated she did not have an email and was computer illiterate. The reporter and Primary Care HCP (health care professional) consented to follow-up. This case was considered as suspected vaccination failure as details regarding time to onset and laboratory test confirming herpes zoster were unknown at the time of reporting. For tolerance of Valacyclovir refer case US2021AMR116456, reported by same reporter.; Sender's Comments:  US-GLAXOSMITHKLINE-US2021AMR116381:Same reporter US-GLAXOSMITHKLINE-US2021AMR116456:Same reporter