Heart attack; Blood clot headed for her lungs; Muscle was a bit damaged/had surgery to repair a tear in the heart; NON ST elevation MI; Coronary artery dissection aka rpda dissection; Aches; Heart disease (unspecified); Fever of 102 degress; mild headache; Feet were blue, swollen, and painful; Feet were blue, swollen, and painful; Feet were blue, swollen, and painful; Dizziness; This spontaneous case was reported by a consumer and describes the occurrence of MYOCARDIAL INFARCTION (Heart attack), PULMONARY THROMBOSIS (Blood clot headed for her lungs), MYOCARDIAL RUPTURE (Muscle was a bit damaged/had surgery to repair a tear in the heart), ACUTE MYOCARDIAL INFARCTION (NON ST elevation MI) and CORONARY ARTERY DISSECTION (Coronary artery dissection aka rpda dissection) in a 57-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.    Co-suspect product included non-company product ELIGLUSTAT capsule, hard for Gaucher's disease.    The patient's past medical history included Anxiety, Unspecified complication of pregnancy (approximately 20 years ago) in 2001 and Heart attack in 2013.   On 17-Nov-2014, the patient started ELIGLUSTAT (Oral) 84 milligram every twelve hours. On an unknown date, the patient received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On an unknown date, received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. In 2020, the patient experienced PERIPHERAL SWELLING (Feet were blue, swollen, and painful), SKIN DISCOLOURATION (Feet were blue, swollen, and painful) and PAIN IN EXTREMITY (Feet were blue, swollen, and painful). On 25-Oct-2020, the patient experienced MYOCARDIAL INFARCTION (Heart attack) (seriousness criteria hospitalization and medically significant), PULMONARY THROMBOSIS (Blood clot headed for her lungs) (seriousness criteria hospitalization and medically significant), MYOCARDIAL RUPTURE (Muscle was a bit damaged/had surgery to repair a tear in the heart) (seriousness criteria hospitalization and medically significant), ACUTE MYOCARDIAL INFARCTION (NON ST elevation MI) (seriousness criteria hospitalization and medically significant) and CORONARY ARTERY DISSECTION (Coronary artery dissection aka rpda dissection) (seriousness criteria hospitalization and medically significant). On an unknown date, the patient experienced PAIN (Aches), CARDIAC DISORDER (Heart disease (unspecified)), PYREXIA (Fever of 102 degress) and HEADACHE (mild headache). The patient was hospitalized from 25-Oct-2020 to 29-Oct-2020 due to ACUTE MYOCARDIAL INFARCTION, CORONARY ARTERY DISSECTION, MYOCARDIAL INFARCTION, MYOCARDIAL RUPTURE and PULMONARY THROMBOSIS. The patient was treated with Surgery for Myocardial rupture. In 2020, PERIPHERAL SWELLING (Feet were blue, swollen, and painful), SKIN DISCOLOURATION (Feet were blue, swollen, and painful) and PAIN IN EXTREMITY (Feet were blue, swollen, and painful) had resolved. At the time of the report, MYOCARDIAL INFARCTION (Heart attack), PULMONARY THROMBOSIS (Blood clot headed for her lungs), MYOCARDIAL RUPTURE (Muscle was a bit damaged/had surgery to repair a tear in the heart), ACUTE MYOCARDIAL INFARCTION (NON ST elevation MI) and CORONARY ARTERY DISSECTION (Coronary artery dissection aka rpda dissection) was resolving and PAIN (Aches), CARDIAC DISORDER (Heart disease (unspecified)), PYREXIA (Fever of 102 degress) and HEADACHE (mild headache) outcome was unknown.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On an unknown date, Body temperature: 102 degree Celsius. On an unknown date, Heart rate: low.         Action taken with mRNA-1273 in response to the events was not applicable. Treatment details included unspecified treatment for heart attack, surgery for myocardial rupture, blood thinners and IVs for pulmonary thrombosis.   Patient had a fever of 102 degrees, aches and a mild headache after her second covid-19 vaccination.  Reporter stated that the symptoms in her feet resolved after the treatment for her heart attack and as per patients cardiologist, it was suspected that she had heart disease.  No concomitant medications were reported.  Company comment:Based on the current available information and temporal association between the use of the product and the start date of the events, a causal relationship cannot be excluded.   Most recent FOLLOW-UP information incorporated above includes: On 02-Jun-2021: Upon internal review on 08-DEC-2022 non-significant corrections performed to update "case received from field" to blank; Sender's Comments: Based on the current available information and temporal association between the use of the product and the start date of the events, a causal relationship cannot be excluded.