Rebound Covid at day 10 and positive Covid test. (I had tested negative three times since last Wednesday); This spontaneous case was reported by an other health care professional and describes the occurrence of COVID-19 (Rebound Covid at day 10 and positive Covid test. (I had tested negative three times since last Wednesday)) in a 37-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch no. 076c21a) for COVID-19 vaccination.  Concurrent medical conditions included Anxiety, Histoplasmosis retinitis (presumed histoplasmosis which manifests as lesions in retinas), Granuloma (granulomas in lungs and chest) and Drug allergy (Sulfa).  On 24-Oct-2021, the patient received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 20-May-2022 at 9:00 AM,  after starting mRNA-1273 (Moderna COVID-19 Vaccine), the patient experienced COVID-19 (Rebound Covid at day 10 and positive Covid test. (I had tested negative three times since last Wednesday)). The patient was treated with NIRMATRELVIR, RITONAVIR (PAXLOVID) from 10-May-2022 to 15-May-2022 for COVID-19 treatment, at a dose of 1 dosage form. At the time of the report, COVID-19 (Rebound Covid at day 10 and positive Covid test. (I had tested negative three times since last Wednesday)) had not resolved.  DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On 20-May-2022, SARS-CoV-2 test: positive (Positive) Positive. On an unknown date, SARS-CoV-2 test: negative (Negative) Negative, negative (Negative) Negative and negative (Negative) Negative.  For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown), the reporter did not provide any causality assessments.  No concomitant medications were reported. It was reported that the patient did not received any medications or products within 2 weeks of starting COVID-19 treatment. At day 10 COVID-19 was rebounded, with chest congestion, fatigue and positive COVID test. Patient had tested negative three times since last Wednesday. The device date was 20-May-2022.  Company comment: This spontaneous case concerns a female patient aged 37 years, with no relevant medical history reported, who experienced the non-serious unexpected AESI of COVID-19 on an unknown date after third dose of mRNA-1273 vaccine. Patient was being treated with Paxlovid (NIRMATRELVIR, RITONAVIR) for Covid from 10th to 15th May2022, Patient reported Rebound Covid at day 10 of Paxlovid treatment. No further details on initial vaccination schedule, clinical course, lab test results before paxlovid treatment were reported. Outcome of the event was not resolved at the time of report. The current pandemic situation of COVID 19 may remain as confounder to the event Covid-19.  The benefit-risk relationship of mRNA-1273 Vaccine is not affected by this report.; Sender's Comments: This spontaneous case concerns a female patient aged 37 years, with no relevant medical history reported, who experienced the non-serious unexpected AESI of COVID-19 on an unknown date after third dose of mRNA-1273 vaccine. Patient was being treated with Paxlovid (NIRMATRELVIR, RITONAVIR) for Covid from 10th to 15th May2022, Patient reported Rebound Covid at day 10 of Paxlovid treatment. No further details on initial vaccination schedule, clinical course, lab test results before paxlovid treatment were reported. Outcome of the event was not resolved at the time of report. The current pandemic situation of COVID 19 may remain as confounder to the event Covid-19.  The benefit-risk relationship of mRNA-1273 Vaccine is not affected by this report.