Swollen red hands; Tight, swollen knees; legs/knees continue to be abnormal - achey; legs/knees continue to be abnormal - achey and heavy - and getting worse each day.; Pain is better upon awakening but within a couple of hours must sit down and put legs up.; Cannot squat down and get up without being sure I am able to grab onto something to pull myself up.; Ascending stairs difficult as day progresses.; tight, swollen red hands; tight, swollen knees; Legs/knees continue to be abnormal - achey; Arm pain; Fatigue; Headaches; Loss of appetite; Slept a lot; This is a spontaneous report from a contactable consumer, the patient. A 67-year-old non-pregnant female patient received the second dose of BNT162b2 (PFIZER-BIONTECH COVID-19 mRNA VACCINE; Lot Number: EL9267), via an unspecified route of administration in the left arm on 22Feb2021 at 12:15 (at the age of 67-years-old), as a single dose for COVID-19 immunisation. Medical history included osteoarthritis for 20 years. Concomitant medications included Vitamin d nos. (VITAMIN D) from an unknown date for unknown indication. The patient previously received the first dose of BNT162b2 (PFIZER-BIONTECH COVID-19 mRNA VACCINE, Lot number: EL9267), via an unspecified route of administration in the left arm on 25Jan2021 at 12:15 (at the age of 67-years-old), as a single dose for COVID-19 immunisation. The patient previously took codeine (MANUFACTURER UNKNOWN) on unknown date for an unspecified indication and experienced drug allergy. Prior to the vaccination, the patient was not diagnosed with COVID-19. Since the vaccination, the patient had not been tested for COVID-19. The patient did not receive any other vaccines within four weeks prior to the vaccination. On 23Feb2021 at 08:00, the patient experienced arm pain, fatigue, headaches, and loss of appetite. She went to bed and slept a lot. During the 12 days to follow, she had some headache and fatigue. She followed her normal routine. However, on an unknown date in Mar2021, 2 weeks after 2nd shot when taking a walk, the patient experienced tight, swollen knees and tight, swollen red hands. Next day knees/legs still not normal. Since then, her legs/knees continue to be abnormal, achey, heavy and getting worse each day. Ascending stairs difficult as day progresses. Yoga was always easy for her and now she could not squat down and get up without being sure she was able to grab onto something to pull herself up. Pain was better upon awakening but within a couple of hours the patient must sit down and put her legs up. The patient could always walk for miles with absolutely no issues. She saw her doctor on 06May2021. Surprisingly, recent blood test does not show inflammation. The events resulted in doctor or other healthcare professional office/clinic visit. Therapeutic measures were taken as a result of the events. The clinical outcome of the events arm pain, fatigue, headaches, and loss of appetite, slept a lot, swollen knees and tight, swollen red hands, knees/legs still not normal, legs/knees continue to be abnormal- achey, heavy and getting worse each day, ascending stairs difficult, cannot squat down and get up without being sure able to grab onto something to pull herself up, pain is better upon awakening but within a couple of hours must sit down and put legs up were not resolved at the time of reporting.   No follow-up attempts are needed. No further information is expected.