he feels like his throat is so raw; Second COVID-19 vaccine: sore arm; Second COVID-19 vaccine: feeling achy/ Her husband is still sore/achy today; Second COVID-19 vaccine: nauseous; Second COVID-19 vaccine: vomiting/ throwing up; Second COVID-19 vaccine: diarrhea; Second COVID-19 vaccine: fatigue; vomiting blood; Second COVID-19 vaccine: blood in the phlegm or just whatever he spit up / spitting up blood; Second COVID-19 vaccine: Chilly; Second COVID-19 vaccine: redness around his eyes, like under his eyelids; his pores looked red; This is a spontaneous report from a contactable consumer (wife). A 33-year-old patient (husband) received the second dose of BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE) via an unspecified route of administration administered in right arm on 05Apr2021 15:40 (Lot Number: ER8734) at single dose for COVID-19 immunization. Medical history included atopic dermatitis. Concomitant medication included dupilumab (DUPIXENT), an injection that patient takes every other week to control his atopic dermatitis, he has been using this for 3 years at least. The patient previously received the first dose of BNT162B2 (Lot number: ER6207) in left shoulder on 15Mar2021 15:40, at the age of 32 years old, for COVID-19 immunization, and experienced arm sore and body aches. The patient experienced vomiting blood in Apr2021, blood in the phlegm or just whatever he spit up / spitting up blood in Apr2021, he feels like his throat is so raw on 05Apr2021, sore arm on 05Apr2021, feeling achy/ her husband is still sore/achy today on 05Apr2021, nauseous on 05Apr2021, vomiting/ throwing up on 05Apr2021, diarrhea on 05Apr2021, chilly in Apr2021, redness around his eyes, like under his eyelids; his pores looked red in Apr2021, fatigue on 05Apr2021. No treatment received for the adverse events. Outcome of the events pain in arm, ache, nauseous, erythema, fatigue was not recovered, of the other events was unknown.   Clinical course as reported: Her husband got their second dose of the vaccine on 05Apr2021. Her husband was having a more severe reaction than the first time. The first time he got the vaccine his arm was sore. Last night (05Apr2021), the caller's husband was vomiting just over and over and had diarrhea, both at the same time. Wife added the thing she was worried about was that her husband was vomiting blood as well, and that her husband said it was from the phlegm, like he felt like his throat was so raw. Her husband did not really want to eat anything which she expected was normal. She was trying to give him fluids, and having him drink a little bit. Her husband had not vomited since around 4 am. And right now, he was sleeping. She did not know if she should give him medicine or take him to be seen or if this was a normal reaction to the vaccination. She did read side effects from the paper and she saw that some vomiting was expected but the blood was what caught her off guard. Around 10 o'clock last night (05Apr2021), her husband felt nauseous and went to bed. She actually fell asleep on the couch and heard her husband vomiting across the house, that was how bad the vomiting was. The vomiting started at midnight last night (05Apr2021). Her husband has been vomiting every couple of hours (2 hours), around the clock. Diarrhea had been at the same time. From her understanding, her husband had vomited at least 3 or 4 times, and had diarrhea 3 or 4 times. She kind of lost track after the 3rd time, but she had not heard him since around 4 am Her husband was still sore/achy today (06Apr2020) and was is still nauseous. She believed he was also feeling chilly. He was wrapped up in his blanket. Her husband did not have a fever, she has been checking his temperature. Wife stated no treatment yet, as she did not know what was safe. Her husband wanted to wait until he stopped vomiting because anything he put in his stomach came right back up. After the first time her husband was done throwing up, and was only dry heaving, he started to like kind of spit. When he would gargle or spit, there was blood in the phlegm or just whatever he spit up. The first time the wife went to check on him, she saw him spitting up blood. It was not like his vomit was red with blood in it, it was just the after effects, so she thought she should call and report this. Each time he has vomited, there was still that spit up of blood afterwards. The patient himself clarified the vomiting was last around 4 am (06Apr2020), give or take, and the last stool/bout of diarrhea was around 7 am (06Apr2020). He was still feeling nauseous and fatigued. He added that after the first time he vomited and the couple times he checked later on, he looked in the mirror and saw that there was this redness around his eyes, like under his eyelids. He adds it was red, it wasn't like splotchy, but it was like his pores looked red, like pinpoints. The patient clarified that the fatigue and achiness probably started around the first time he vomited, and that was still hanging around. The wife stated this was better than him getting Covid. Wife added what she was trying to see was if she should take her husband to the hospital or not. She did not want to wait too long, but if this was something that was a side effect that was expected, then her husband could just sleep it off.