possible stroke; face is drooping a little; had numbness and tingling  on the left side of my face; had numbness and tingling  on the left side of my face; red splotches about the size of a small leaf from injection site to elbow; had a rash opposite the injection site; a vein protruded out; bone chilling chills; deep pain in my arm that feel like someone was beating me; arm sore to touch; my arm was sore to touch from injection site to elbow; had a fever of 103 F/low grade (~99 F); I was shaking; blood pressure went up to 149/89; my heart rate was elevated to over 110; dull headache off and on since receiving the vaccine; A spontaneous report was received from a nurse who was also a 66-years old female patient who received Moderna's COVID-19 Vaccine (mRNA-1273) and experienced possible stroke, face is drooping a little, a vein protruded out, blood pressure went up to 149/89, my heart rate was elevated to over 110, deep pain in my arm that feel like someone was beating me; arm sore to touch; my arm was sore to touch from injection site to elbow,  I was shaking, had numbness and tingling  on the left side of my face, red splotches about the size of a small leaf from injection site to elbow, dull headache off and on since receiving the vaccine, had a rash opposite the injection site, my arm was sore to touch from injection site to elbow, bone chilling chills, and had a fever of 103 degrees Fahrenheit (F)/low grade (~99 F).    The patient's medical history was not provided.  There were no concomitant medications provided.  On 08 Jan 2021 the patient received the first of two planned doses of mRNA-1273 (Lot number unknown) intramuscularly, in her right arm, for prophylaxis of COVID-19 infection.  On 08 Jan 2021 at 3:00 pm, the patient received her first injection. Right after the injection, her blood pressure went up to 149/89 and her heart rate was elevated to over 110 and both came down to normal by 4 pm. A dull headache started on the same day.  About midnight on 09 Jan 2021, the patient was awakened by deep vein in her arm that felt like someone was beating her. About 11 am the same day she had a fever of 103 degrees Fahrenheit, bone chilling chills., and she was shaking. Treatment included a hot shower, ibuprofen, paracetamol, and acetylsalicylic acid. The chills and shaking stopped after treatment. It was noted that fever lowered to about 99 degrees.  On 11 Jan 2021, the patient had red splotches about the size of a small leaf and her arm was sore to touch from injection site to elbow. A vein protruded out and she had a rash opposite the injection site.   On 12 Jan 2021, the fever had resolved.  The patient noted that all right arm reaction lasted until Saturday, 16 Jan 2021.  On 19 Jan 2021 in the evening, the patient had numbness on the left side of her face. It appeared as if her face was drooping a little, but there was nothing wrong with her smile or her speech. She noted she called the clinic and they wanted her to come in to determine if she had a possible stroke. Additionally, she reported she had a dull headache off and on since she got the vaccine.  Action taken with mRNA-1273 in response to the event was not provided.  The event of dull headache off and on since receiving the vaccine was not recovered/not resolved. The outcome for the events, possible stroke, face is drooping a little, had numbness and tingling on the left side of my face, was unknown. The outcome of the events, a vein protruded out, blood pressure went up to 149/89, my heart rate was elevated to over 110, deep pain in my arm that feel like someone was beating me; arm sore to touch; my arm was sore to touch from injection site to elbow,  I was shaking, red splotches about the size of a small leaf from injection site to elbow,  had a rash opposite the injection site, bone chilling chills, and had a fever of 103 F/low grade (~99 F) were resolved at the time of this report.; Reporter's Comments: This spontaneous report concerns a 66-years old female patient who experienced possible stroke, face is drooping a little, a vein protruded out, blood pressure went up to 149/89, my heart rate was elevated to over 110, deep pain in my arm that feel like someone was beating me; arm sore to touch; my arm was sore to touch from injection site to elbow,  I was shaking, had numbness and tingling  on the left side of my face, red splotches about the size of a small leaf from injection site to elbow, dull headache off and on since receiving the vaccine, had a rash opposite the injection site, my arm was sore to touch from injection site to elbow, bone chilling chills, and had a fever of 103 degrees Fahrenheit (F)/low grade (~99 F).  The events of blood pressure went up, heart rate elevated and dull headache occurred on the same day after the administration of the first dose of mRNA-1273 ((lot number unknown) and events of deep vein in her arm that felt like someone was beating her, fever of 103 degrees Fahrenheit, bone chilling chills., shaking occurred  1 day after. The events of red splotches, arm was sore to touch from injection site to elbow, a vein protruded out, rash opposite the injection site developed 3 days after the vaccine dose and numbness on the left side of her face and possible stroke occurred 11 days after the vaccine dose. Treatment provided, fever and dull headache are resolved, and outcome of other events are unknown. He events of injection site redness and pain, fever, rash chills and headaches are consistent with the safety profile of the vaccine. Based on the current available information and temporal association between the use of the product and onset of the reported events a causal relationship cannot be excluded