Slight headache/Frontal and temporal lobe headache; Had an allergic response; This non-serious case was reported by a nurse via other manufacturer and described the occurrence of headache in a patient who received Herpes zoster (Shingrix) for prophylaxis.   Co-suspect products included TOZINAMERAN (COMIRNATY) for prophylaxis and INFLUENZA VACCINE for prophylaxis.   The patient's past medical history included breast cancer (got three times), shingles (2 episode), hives (at teenager) and difficulty breathing (at teenager). Concurrent medical conditions included diabetes, allergy to antibiotic and drug allergy (Allergic to adult dose of Aspirin).   On 10-OCT-2023 12:15, the patient received Shingrix (right arm) and COMIRNATY (left arm). On 10-OCT-2023 11:00, the patient received INFLUENZA VACCINE (left arm). On 11-OCT-2023 11:00, 1 days after receiving Shingrix, the patient experienced headache (Verbatim: Slight headache/Frontal and temporal lobe headache). In OCT-2023, the patient experienced allergic reaction (Verbatim: Had an allergic response). The patient was treated with ibuprofen, benadryl (nos) (Benadryl), paracetamol (Tylenol), paracetamol (Acetaminophen) and diphenhydramine. The outcome of the headache and allergic reaction were resolving.   It was unknown if the reporter considered the headache and allergic reaction to be related to Shingrix.   It was unknown if the company considered the headache and allergic reaction to be related to Shingrix.   Additional Information: GSK Receipt Date: 23-OCT-2023 The reporter stated that he/she thought he/she had an allergic response to three vaccines, that he/she got on Tuesday.  The patient got the new COVID-19, he/she thought that he/she got the double variant flu because he/she was diabetic and he/she got the shingles (later clarified as Shingrix) because he/she thought he/she had two episodes in the past and he/she just wanted to be covered up with something like vaccines.  The reporter stated that it was Comirnaty and the Flu, the double variant. When paraphrased the above concerned, consumer stated that he/she had allergy to Tetracycline and he/she was allergic to adult dose aspirin (known medical condition). His/her flu shot was in his/her doctor's office and Covid and shingles shot is in the clinic. They did not give him/her a card. That's what on the prescription tab that came with the medicine. The patient went to the pharmacy and they give it to him/her.  They did not have anything on the paper as to the dosage. The reporter stated that he/she could give the date.  The reporter would give the time because he/she had it scheduled (incomplete sentence).  The patient got one at the doctor's office at about 11 o' clock, that was the flu shot. Then he/she went by the clinic, all the way home and he/she got the Covid and the Shingrix (suspect captured as provided). The reporter stated that no, all he/she knew it was Flu Valent, it was the number two, it' was the stronger dose because he/she had been long term Diabetic. The Flu and the Covid was on the left arm and the Shingrix was on the right. The indication of Flu and Shingrix vaccine, the reporter stated that got it every year. The patient had long standing allergies. The patient had lab on Monday when he/she went to his/her oncologist. All of them were normal except one but it was like anion gap and he/she could not remember on the top of his/her head and since he/she was on his/her phone and he/she go through his/her phone but everything else was normal.  He/she thought that it was with his/her blood count, one of those RBC ratios or something (consumer was not sure hence not captured) and it was on the low side. The patient started when he/she got up the next morning.  The patient had a slight headache. So, he/she took the Ibuprofen, he/she took 800 milligrams of Ibuprofen and took a nap.  It about might be around 24 or 26 hours something like that it was less than 12 hours because he/she got it around 11 and he/she started with a headache around 11, the next day. So, it was about 12 hours. It was left side, frontal and temporal lobe headache. The patient was still experiencing the events. The patient took it (Ibuprofen) around 11 and he/she took it again around 1 o' clock in the morning because it was like mid-day. It was like 12. When probed if have both medication handy (Tetracycline and adult dose Aspirin), the reporter stated that he/she had not that since he/she was a teenager and had the allergic reaction. The reporter stated that he/she could tell what happened to him/her, when he/she took the product that the patient had difficulty breathing and he/she had hives, difficulty in breathing when that happened when he/she was a teenager. The reporter stated that he/she was just note that the symptoms were subsiding. They started to subside after he/she took the Benadryl (suspect captured conservatively), Tylenol PM, but it was long out taking the Ibuprofen about every 8 hours and so or 5 hours.  The patient had the headache again, 5 hours and started to have more now. When clarified that after taking Ibuprofen headache was persisting, consumer stated that he/she switched from Ibuprofen to the Benadryl and Tylenol.  They all were subsiding, but he/she knew that they (adverse effects) were still there, so, he/she was going to have and took other dose in little bit. When probed if the consumer had the medications with them (Ibuprofen, Tylenol and Benadryl), consumer stated that he/she just had Ibuprofen left. The patient had the Tylenol medication handy. The reporter stated that stated that it was the again and it was Tylenol no, it was Acetaminophen. When probed to clarify if the consumer were taking Tylenol or Acetaminophen, consumer stated he/she was taking generic name Acetaminophen with Diphenhydramine. The patient received expired dose of Acetaminophen but it worked.