blood test showed aggresstion stage of rheumatoid arthritis; a lot of pain in knuckles, thumb, wrist; hands were numb; swelling; pain in right hand; Based on the current case data, this case has been classified as invalid. This spontaneous case was reported by a consumer and describes the occurrence of RHEUMATOID ARTHRITIS (blood test showed aggresstion stage of rheumatoid arthritis) in a 79-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 032L20A and 011L20A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     Concomitant products included CHONDROITIN SULFATE SODIUM, GLUCOSAMINE HYDROCHLORIDE (GLUCOSAMINE+CHONDROITIN SULPHATE) for Arthritis, MONASCUS PURPUREUS (RED YEAST RICE) for Cholesterol, UBIDECARENONE (COQ10 [UBIDECARENONE]) for Heart disorder and Cholesterol, THIOCTIC ACID (ALA [THIOCTIC ACID]) for Hyperglycaemia and Nerve pain, TRAZODONE for Insomnia, OXITRIPTAN (5-HTP [OXITRIPTAN]) for Mood disorder, SITOSTEROL (MODUCARE), DHEA, CYANOCOBALAMIN (B12 [CYANOCOBALAMIN]), MENAQUINONE-7 (K2), MELATONIN, BORON, FISH OIL (OMEGA 3 FISH OILS), BIFIDOBACTERIUM LACTIS (PROBIOTIC [BIFIDOBACTERIUM LACTIS]), COLECALCIFEROL (VITAMIN D [COLECALCIFEROL]) and CURCUMA LONGA (TURMERIC [CURCUMA LONGA]) for an unknown indication.   On 11-Jan-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 08-Feb-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 13-Mar-2021, the patient experienced RHEUMATOID ARTHRITIS (blood test showed aggresstion stage of rheumatoid arthritis) (seriousness criterion medically significant), ARTHRITIS (a lot of pain in knuckles, thumb, wrist), HYPOAESTHESIA (hands were numb), SWELLING (swelling) and PAIN IN EXTREMITY (pain in right hand). The patient was treated with IBUPROFEN at an unspecified dose and frequency; PREDNISONE on 17-Jul-2021 for Rheumatoid arthritis, at a dose of 5 mg; MELOXICAM for Pain, at a dose of 7.5 mg and HYDROXYCHLOROQUINE at an unspecified dose and frequency. At the time of the report, RHEUMATOID ARTHRITIS (blood test showed aggresstion stage of rheumatoid arthritis), ARTHRITIS (a lot of pain in knuckles, thumb, wrist), HYPOAESTHESIA (hands were numb), SWELLING (swelling) and PAIN IN EXTREMITY (pain in right hand) had resolved.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On an unknown date, Blood test: abnormal (abnormal) Aggression stage of Rheumatoid arthritis .. On an unknown date, X-ray: abnormal (abnormal) Inflamed osteoarthritis.     For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown), the reporter considered RHEUMATOID ARTHRITIS (blood test showed aggresstion stage of rheumatoid arthritis), ARTHRITIS (a lot of pain in knuckles, thumb, wrist), HYPOAESTHESIA (hands were numb), SWELLING (swelling) and PAIN IN EXTREMITY (pain in right hand) to be probably related.    Patient was referred for a physical therapy by her doctor and also stated that she was about to stop HCQ as it is causing too many side effects .  Patient reported that Osteoarthritis had become much worse in her fingers and other parts of her body which was only mild to moderate before . She had an appointment to have an Ultrasound to see if there is any tissue damage . She stated that she must have had a  dormant factor for Rheumatoid arthritis and the vaccine for COVID-19 brought it out .  Bio identical Hormones- Topical brest 80/20, Progest/test 1mg/100mg/1mg/gm anti versame .  Based on the current available information and temporal association between the use of the product, and the start date of the events, a causal relationship cannot be excluded.   Most recent FOLLOW-UP information incorporated above includes: On 31-Jul-2021: Follow up received contains Patient details, Dose 1 and 2 details, Concomitant and treatment drugs, New events, lad data . On 31-Jul-2021: Concomitant medications added .; Sender's Comments: Based on the current available information and temporal association between the use of the product, and the start date of the events, a causal relationship cannot be excluded.