This spontaneous case was reported by a patient and describes the occurrence of MALAISE (Still does not feel well today/I still have general malaise/it is not as bad as it was before), ILLNESS (Several hours later I became very sick/very ill), HYPERHIDROSIS (Extreme sweating/I sweat profusely with sleep the first night), VACCINATION SITE PAIN (it started hurting/as soon as the Pharmacist put the needle, I flinched) and CHILLS (Chills) in a 52-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch no. 011B22A) for COVID-19 prophylaxis. The occurrence of additional non-serious events is detailed below. No other vaccines given within 1 month prior to Moderna COVID-19 vaccine. The patient's past medical history included COVID-19 on 23-Nov-2020. Previously administered products included for Product used for unknown indication: Pfizer (Dose number 1) on 12-Mar-2021, Pfizer (Dose number 2, batch number ER8733) on 01-Apr-2021, Pfizer (1st Booster and batch number ER8733) on 03-Dec-2021. Past adverse reactions to the above products included Unwell with Pfizer, Pfizer and Pfizer. Concurrent medical conditions included Latex allergy, Drug allergy (Lexapro), Penicillin allergy and Drug allergy (Afrin). On 30-Jul-2022, the patient received fourth dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 30-Jul-2022, the patient experienced ILLNESS (Several hours later I became very sick/very ill), HYPERHIDROSIS (Extreme sweating/I sweat profusely with sleep the first night), VACCINATION SITE PAIN (it started hurting/as soon as the Pharmacist put the needle, I flinched), CHILLS (Chills) and MYALGIA (Body aches). On 01-Aug-2022, the patient experienced MALAISE (Still does not feel well today/I still have general malaise/it is not as bad as it was before). On 31-Jul-2022, ILLNESS (Several hours later I became very sick/very ill), HYPERHIDROSIS (Extreme sweating/I sweat profusely with sleep the first night), CHILLS (Chills) and MYALGIA (Body aches) had resolved. At the time of the report, MALAISE (Still does not feel well today/I still have general malaise/it is not as bad as it was before) had not resolved and VACCINATION SITE PAIN (it started hurting/as soon as the Pharmacist put the needle, I flinched) outcome was unknown. Concomitant medications were not reported. The patient had received second booster. The patient had reported that while receiving the injection, it felt weird, it did not hurt initially but as soon as the pharmacist put the needle in, patient flinched because it started hurting.  Patient reported never experienced had this with any other vaccinations before. The only time patient had felt this reaction, when patient received other shots to get tested for allergies. Several hours after received the vaccine, patient became very sick and ill. Patient experienced chills, extreme sweating and body aches. All these symptoms lasted for about 24 hours. Patient felt like it was an extreme reaction and felt very similar to the first time, when with COVID during the early pandemic. Patient at the time of reporting reported that felt much better but still does not feel back to normal. Patient had general malaise, however, it was not as bad as it was on the first day after getting the shot. Patient reported the first night had profuse sweating but did not experience that last night on 31-Jul-2022. Patient had took over the counter medications for the body aches, but they did not help at all.