Diarrhea every 4 days; vomiting every 4 days; Fever not very high (99F) once a week; Quite ill; Does not have the same energy to do her usual activities; Does not have the same energy to do her usual activities/debilitating feeling; Feels terrible/does not feel like the way she felt before; This spontaneous case was reported by a patient and describes the occurrence of LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (Does not have the same energy to do her usual activities), ASTHENIA (Does not have the same energy to do her usual activities/debilitating feeling), FEELING ABNORMAL (Feels terrible/does not feel like the way she felt before), ILLNESS (Quite ill) and DIARRHOEA (Diarrhea every 4 days) in a 55-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 005M21A, 039D21A, 002A21A and 032L20A) for COVID-19 prophylaxis. The occurrence of additional non-serious events is detailed below.     The patient's past medical history included Lung cancer (Not had any chemotherapy or radiation therapy after getting 1st dose of vaccine.) in 2017. Previously administered products included for Flu vaccination: flu vaccine (Jan or Feb 2022) in 2022. Past adverse reactions to the above products included No adverse event with flu vaccine. Concurrent medical conditions included Drug allergy (Codeine) and Allergy to antibiotic (Erythromycin).   On 26-Jan-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 01-Mar-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 18-Nov-2021, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 27-Apr-2022, received fourth dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. In April 2022, the patient experienced ILLNESS (Quite ill). On 27-Apr-2022,  after starting mRNA-1273 (Moderna COVID-19 Vaccine), the patient experienced DIARRHOEA (Diarrhea every 4 days), VOMITING (vomiting every 4 days) and PYREXIA (Fever not very high (99F) once a week). In 2022, the patient experienced LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (Does not have the same energy to do her usual activities), ASTHENIA (Does not have the same energy to do her usual activities/debilitating feeling) and FEELING ABNORMAL (Feels terrible/does not feel like the way she felt before). At the time of the report, LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (Does not have the same energy to do her usual activities), ASTHENIA (Does not have the same energy to do her usual activities/debilitating feeling), FEELING ABNORMAL (Feels terrible/does not feel like the way she felt before), ILLNESS (Quite ill), DIARRHOEA (Diarrhea every 4 days), VOMITING (vomiting every 4 days) and PYREXIA (Fever not very high (99F) once a week) had not resolved.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On 27-Apr-2022, Body temperature: 99 99 F. On an unknown date, SARS-CoV-2 test: (Negative) had dozens of COVID tests which were all negative.     For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown), the reporter considered LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (Does not have the same energy to do her usual activities), ASTHENIA (Does not have the same energy to do her usual activities/debilitating feeling), FEELING ABNORMAL (Feels terrible/does not feel like the way she felt before), ILLNESS (Quite ill), DIARRHOEA (Diarrhea every 4 days), VOMITING (vomiting every 4 days) and PYREXIA (Fever not very high (99F) once a week) to be possibly related.    The patient does not experienced a similar event in the past.  No concomitant product use was provided.   The patient does not feel like the way she felt before. She said she has been quite ill since she got the 2nd booster. She consulted with her oncologist who advised her to call Moderna and see what recommendations can be given to her regarding her side effects. She was told that these could be possibly due to the booster dose. No medications were given.   This case was linked to MOD-2022-610334 (Patient Link).