After the rash and discoloration subsided the skin started peeling a lot/The hands healed but feet still having sloughing off of skin almost like its a shell on bottom of feet; The skin felt leathery to certain extent on palms and bottom of feet; Had splotchy discoloration on hands and feet; Had rash there but started turning purple; Edema occurred in hands and feet; Had lots of severe itching this whole time; Had some itching on feet and rash broke out there; rash started in her wrist area and expanded to rest of hand and fingers; This spontaneous case was reported by a consumer and describes the occurrence of SKIN DISCOLOURATION (Had splotchy discoloration on hands and feet), PURPURA (Had rash there but started turning purple), OEDEMA PERIPHERAL (Edema occurred in hands and feet), PRURITUS (Had lots of severe itching this whole time) and SKIN EXFOLIATION (After the rash and discoloration subsided the skin started peeling a lot/The hands healed but feet still having sloughing off of skin almost like its a shell on bottom of feet) in a 60-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 017B21A and 039B21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     Medical history was not reported.  Concomitant products included DUPILUMAB (DUPIXENT) for an unknown indication.   On 23-Mar-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 20-Apr-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. On 04-Apr-2021, the patient experienced RASH PRURITIC (Had some itching on feet and rash broke out there). 04-Apr-2021, the patient experienced RASH (rash started in her wrist area and expanded to rest of hand and fingers). On 08-Apr-2021, the patient experienced SKIN DISCOLOURATION (Had splotchy discoloration on hands and feet), PURPURA (Had rash there but started turning purple), OEDEMA PERIPHERAL (Edema occurred in hands and feet) and PRURITUS (Had lots of severe itching this whole time). On an unknown date, the patient experienced SKIN EXFOLIATION (After the rash and discoloration subsided the skin started peeling a lot/The hands healed but feet still having sloughing off of skin almost like its a shell on bottom of feet) and SKIN HYPERTROPHY (The skin felt leathery to certain extent on palms and bottom of feet). The patient was treated with PARACETAMOL (TYLENOL EXTRA STRENGTH) from April 2021 to April 2021 at a dose of UNK, one time dose and BETAMETHASONE at an unspecified dose and frequency. At the time of the report, SKIN DISCOLOURATION (Had splotchy discoloration on hands and feet), RASH PRURITIC (Had some itching on feet and rash broke out there) and RASH (rash started in her wrist area and expanded to rest of hand and fingers) was resolving, PURPURA (Had rash there but started turning purple), OEDEMA PERIPHERAL (Edema occurred in hands and feet), PRURITUS (Had lots of severe itching this whole time) and SKIN HYPERTROPHY (The skin felt leathery to certain extent on palms and bottom of feet) outcome was unknown and SKIN EXFOLIATION (After the rash and discoloration subsided the skin started peeling a lot/The hands healed but feet still having sloughing off of skin almost like its a shell on bottom of feet) had not resolved.            Action taken with mRNA-1273 in response to the event was not applicable.  The patient reported that she had nothing occur after the second dose.