feeling like his airway is closing off.; blood pressure went up; Throat swelling; He felt like he had a golf ball in his throat or something.; tightness in his chest; problem swallowing; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP) from medical information team. The reporter is the patient.  A 63-year-old male patient received pneumococcal 20-val conj vac (dipht CRM197 protein) (PREVNAR 20), in Oct2022 as dose number unknown, single (Batch/Lot number: unknown) for immunization. The patient's relevant medical history included: "Alpha-gal allergy" (ongoing), notes: alpha gal allergy to red meat. Which can cause 10 major symptoms & he has a epi pen. There were no concomitant medications. The following information was reported: THROAT TIGHTNESS (medically significant), outcome "unknown", described as "feeling like his airway is closing off."; BLOOD PRESSURE INCREASED (medically significant), outcome "not recovered", described as "blood pressure went up"; PHARYNGEAL SWELLING (medically significant), outcome "not recovered", described as "Throat swelling"; SENSATION OF FOREIGN BODY (medically significant), outcome "unknown", described as "He felt like he had a golf ball in his throat or something."; CHEST DISCOMFORT (medically significant), outcome "unknown", described as "tightness in his chest"; DYSPHAGIA (medically significant), outcome "unknown", described as "problem swallowing". The patient underwent the following laboratory tests and procedures: Blood magnesium: in his fluids, notes: He got some magnesium in his fluids; Blood pressure measurement: 220/124, notes: His blood pressure went up./They did put him on blood pressure medications since his blood pressure got to 220/124; Blood test: unknown results, notes: They have done blood work multiple times; Cardiac stress test: normal, notes: His stress test normal; X-ray: unknown results, notes: They have done every test imaginable including x-rays. Therapeutic measures were taken as a result of throat tightness, blood pressure increased. Additional information: The pharmacist he talked to there told him to go to his doctor and get a steroid shot. So he went to his doctor. She said to be careful with it. The steroid shot didn't work. He had to rush to the hospital. His breathing started closing up. He doesn't know the information including Name/ NDC/lot/expiration for the steroid. He called about this. About 2.5 -3 weeks ago, he received the Prevnar 20 vaccine for pneumonia. Later on that day or the next day he started having stuff happening including throat swelling. He felt like he had a golf ball in his throat or something. His blood pressure went up. He has been to many doctors, a cardiologist, and hospital Emergency room doctors trying to figure out what is going on. The prevnar 20 is the only thing he had taken out of normal. His stress test normal. They did put him on blood pressure medications since his blood pressure got to 220/124. When he called poison control, they told him the product does have animal products in it. He has an alpha gal allergy because he was bitten by a deer tick. There are like 10 symptoms of that. He could have died from it. He is trying to figure out what he can do to make this better. He has been hours in the emergency room. All the doctors just seem bewildered. He would have to call (withheld) to get specifics about his shot. He doesn't know the date/ NDC/lot/expiration. The pharmacist he talked to there told him to go to his doctor and get a steroid shot. So he went to his doctor. She said to be careful with it. The steroid shot didn't work. He had to rush to the hospital. His breathing started closing up. He doesn't know the information including Name/ NDC/lot/expiration for the steroid. He is still experiencing all of these side effects. He thought it would get better after the steroid shot. They have done every test imaginable including x-rays. They have persisted. He is still having these side effects. He is having tightness in his chest, a problem swallowing. He is feeling like his airway is closing off. All of these side effects are on the internet. He didn't look up information before he took it. His wife had pneumonia in Mar2022, and they both just decided to take the vaccine. She got it too, but it didn't have any effect on her. He is thinking the alpha gal plays a role. The first time he was in the Emergency room for 14 hours. They found nothing. He got some magnesium in his fluids. Then he went to the (Withheld) Emergency room a couple of days ago. He spent 4 hours in there. They have done blood work multiple times. He doesn't remember what arm he got it in. He got it some time during the middle of the day.  The information on the batch/lot number for pneumococcal 20-val conj vac (dipht CRM197 protein) has been requested and will be submitted if and when received.