couldn't breathe; wife had a nasty reaction; felt like she'd been hit by a truck; couldn't move; didn't feel good; wife feels like something is in her throat; swelled; This is a spontaneous report from a contactable consumer (patient's spouse). A female patient of an unspecified age received bnt162b2 (PFIZER-BIONTECH COVID-19 VACCINE, Formulation: Solution for injection, Batch/Lot Number: EW0179), dose 2 via an unspecified route of administration, administered in arm left on 08Jun2021 as single for COVID-19 immunisation. Medical history included Penicillin allergy. The patient's concomitant medications were not reported. The patient previously received the first dose of bnt162b2 (Lot number: EW0179) for COVID-immunization and experienced no reaction on previous exposure to vaccine. On 08Jun2021 (Tuesday), 45 minutes after the vaccine, on the way home, the patient experienced couldn't breathe and wife had a nasty reaction. The consumer stopped the paramedic in the middle of the road and they took her wife (patient) to the hospital. They asked her if she was ok. The consumer reported that the patient was fine and to worry about them. The consumer reported that the patient swelled. They kept the patient in the hospital until 4 in the afternoon. They gave medications in the hospital and sent the patient home with medication, an Epipen, Benadryl and Prednisone. The patient was given nine, 20mg tablets of Prednisone and ten, 40mg pills of Famotidine. On 09Jun2021 (Wednesday) afternoon, she felt like she'd been hit by a truck and she couldn't move and took Flu Dayquil, went to bed, they gave her some food, and she was ok in the afternoon. She came home and was out. The consumer reported that they went to work and were on their way back, said they own a construction company and it was around 02:00 or 01:00 because they were feeling better. The patient didn't feel good and felt the same way as Tuesday. The patient said no when the consumer asked her if she wanted to go to the hospital and took Benadryl and said she was fine. The consumer kept driving and the patient told she needed to go to the hospital now. The consumer stated that they were 20 minutes away from the hospital and the patient stated she didn't have 20 minutes. The consumer took the patient to the hospital. She was admitted on 10Jun2021 at 02:00 and discharged about 13:00. When the patient was admitted they did an x-ray and blood work. On 11Jun2021, the consumer reported that they were driving and the patient started feeling the same way. They were on the way to the hospital. The consumer confirmed that the patient was breathing and reported that her "wife feels like something is in her throat". It was the same problem the patient had on Tuesday, felt something in her throat. The patient's trachea started closing. They were 5 minutes away or maybe less from the hospital. The consumer confirmed that the patient was breathing, she took another Benadryl and was drinking. The consumer confirmed that the patient could swallow. The patient has taken two Benadryl in about a three hour window. They were gong to do a CT of her throat because the patient felt like she had a ball on her throat. They were also going to look for blood clots in the patient's lungs. The outcome of event couldn't move was resolved in 09Jun2021 and was unknown for the rest of the events.  Information on Lot/Batch number was available. Additional information has been requested.