high fever; high heart rate; low oxygen; high blood pressure; chills; he was confused and out of it; did not have as much confusion as he did with the first dose; weak; This is a spontaneous report from a contactable consumer reported for her father. A 66-year-old male patient received the 2nd dose of BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE, lot number: EN6208) via an unspecified route of administration in the left arm on 15Mar2021 at 11: 00 am for covid-19 immunisation. Medical history included sleep apnea from 2010 and ongoing, hypertension from 2011 and ongoing, polycythemia vera from 2015 and ongoing, two strokes (both in 2016), myasthenia gravis from 2019 and ongoing, mass on kidney (right kidney, Found in 2020 and being monitored), COVID-19 from Dec2020. The patient was negative for COVID as of "13Jan2013" (as reported). The patient was hospitalized for COVID for about a week in Dec2020. Concomitant medications included levothyroxine from 2019 and ongoing for Thyroid maintenance, azathioprine from Aug2020 and ongoing for myasthenia gravis, clopidogrel from 2016 and ongoing for Stroke prevention/ blood thinner, hydrochlorothiazide from 2019 and ongoing for hypertension, nifedipine from 2015 (maybe) and ongoing for hypertension, bisoprolol from maybe like 2015 and ongoing for hypertension, atorvastatin from an unspecified date and from Mar2020 and ongoing at new dosage (unspecified) for blood cholesterol, hydroxycarbamide (HYDROXYUREA) from 2015 and ongoing for polycythaemia vera. The patient previously received the 1st dose of BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE, lot: EN6201) via an unspecified route of administration in the left arm on 11Feb2021 for covid-19 immunisation, experiencing tested for COVID and he tested positive at that time with symptoms on 12Feb2021, unresponsive like he could answer he questions but he was unable to get up to get out to the car to go to the hospital on 12Feb2021 at 14: 00, muscular weakness and confused and out of it/confusion on an unspecified date. The patient got flu shot in Oct2020 and that was the last vaccine prior to COVID shot. The patient had both doses of the COVID vaccine, and both times he ended up in the hospital with a reaction. The reporter stated that the doctors were not calling the patient's reaction an allergic reaction, but the patient had a high fever, a high heart rate, low oxygen, high blood pressure and he would have chills and he was confused and out of it. Caller stated that the patient was currently in the hospital. For the second dose, the patient got the reaction occurred a little quicker, it started around 10 pm yesterday, but it was not really bad until today at 10am, and so that was when the caller called 911 again. Caller stated that today, the patient did not have as much confusion as he did with the first dose, but he was weak, had a high fever, high blood pressure, high heart rate and low oxygen. Caller stated that the patient was sent home after the first dose with a nasal cannula and oxygen but his oxygen was low. Caller reported that the patient went to the ER this morning, he had not yet been discharged but he also had not been admitted to the hospital at the time of this phone call. The patient had covid test on 12Mar2021 with positive result. The reporter stated that she didn't really think anything had been abnormal, other than, she knew the vaccine did not cause someone to get COVID, but the week before his first does, the patient was tested for COVID, and he was negative. The reporter reported that the day the patient went to the hospital on 12Feb2021, he was tested for COVID and he tested positive at that time. Caller reported that she took the patient to his primary care doctor a few days later, and the patient had two tests, both the mouth and nasal swabs and those were both negative. Caller stated that everything else that the hospital tested the patient for, looked good. Caller stated that he had bloodwork done, and cultures and a Chest Xray and everything looked clear and normal. Caller reported that the only thing abnormal was that one COVID test on 12Feb2021, and the caller had him tested again a few days after that, and 10 days after that, and those tests were all negative. The patient was not admitted to the hospital after the first dose, only was in the ER. The patient was currently in the ER and it was unclear if he will be admitted to the hospital or not at the time of this call. Outcome of the events was unknown.