have elevated TSH levels in the more recent labs, they all have gotten the Pfizer covid vaccine also/TSH level is markedly increased/TSH thyroid problem; This is a spontaneous report received from a contactable reporter(s) (Other HCP) from medical information team. The reporter is the patient.  An 80-year-old female patient received BNT162b2 (BNT162B2), as dose number unknown, single (Batch/Lot number: unknown) for covid-19 immunisation; levothyroxine sodium (SYNTHROID), (Batch/Lot number: unknown). The patient's relevant medical history and concomitant medications were not reported. The following information was reported: BLOOD THYROID STIMULATING HORMONE INCREASED (hospitalization), outcome "unknown", described as "had elevated TSH levels in the more recent labs, they all had gotten the Pfizer covid vaccine also/TSH level was markedly increased/TSH thyroid problem". The patient underwent the following laboratory tests and procedures: Blood thyroid stimulating hormone: 57, notes: She stated other people are also experiencing it post covid injection they were having thyroid problems. Members were not having any symptoms but their TSH level was elevated, her was 57. The action taken for levothyroxine sodium was unknown.  Clinical course: Caller stated that she would like to report a concern and obtain some information regarding the Pfizer Covid vaccine, adult. Caller stated she was a nurse practioner. Caller stated that she had noticed with herself, and some of her family members, that the TSH level was markedly increased when taking Synthroid and after receiving the Covid vaccine. Caller does not provide any specific identifiers for her family members. Caller stated she had read information about the Covid vaccine, and it can cause autoimmune difficulties, including thyroid problems. Caller does not specify any details or identifiers. Caller stated that her TSH level came back at 57, and she was experiencing no symptoms. Stated she believes the Covid vaccines could be a contributing factor. Her brother in law is a research scientist, and he told her that every major pharmaceutical company had a research information department, so she wanted to call today and ask her question. Caller was a nurse practitioner who called in and stated that she experienced reaction after getting the Pfizer covid-19 vaccine and this was the TSH thyroid problem, she mentioned that not only herself but her family as well but they're well. She wanted to know if there was more information about this and where she could report it.  The information on the batch/lot number for BNT162b2 has been requested and will be submitted if and when received.; Sender's Comments: As there is limited information in the case provided, the causal association between the event markedly increased/TSH and the suspect drug BNT162B2 cannot be excluded. The case will be reassessed once new information is available. The impact of this report on the benefit/risk profile of the Pfizer product is evaluated as part of Pfizer procedures for safety evaluation, including the review and analysis of aggregate data for adverse events. Any safety concern identified as part of this review, as well as any appropriate action in response, will be promptly notified to regulatory authorities, Ethics Committees, and Investigators, as appropriate.