weird/odd left hand movements, left arm-hand unusable; Indentation at injection site; Black and blue Bruising at injection site, dime-quarter size; Black and blue Bruising at injection site, dime-quarter size; intense pain at injection site; Frozen shoulder; due to keeling their arm straight for extended period of time due to being unable to bend their arm at  the elbow; therapist believes they some type of ulnar nerve damage; carpal  tunnel syndrome; cubital tunnel syndrome; pain in the ring and pinky fingers; Numbness in the ring and pinky fingers, not responding while typing; weird/odd left hand movements, left arm-hand unusable; weird/odd left hand movements, left arm-hand unusable; falling; Balance issues, tripping, falling; lost 16 pounds in the last year; excruciating pain; Atrophy of left hand; Took year off work, inability to complete job, issues cooking, issues driving; Shot not given correctly, "jabbed" their left arm/ HCP's technique may have contributed to issues; This case was reported by a consumer via call center representative and described the occurrence of arm paralysis in a elderly female patient who received Herpes zoster (Shingrix) for prophylaxis.   On an unknown date, the patient received the 1st dose of Shingrix. On an unknown date, unknown after receiving Shingrix, the patient experienced arm paralysis (serious criteria GSK medically significant), injection site indentation, injection site bruising, injection site discoloration, injection site pain, frozen shoulder, arm spasticity, injury to ulnar nerve, carpal tunnel syndrome, cubital tunnel syndrome, pain in fingers, numbness in fingers, injected limb mobility decreased, upper extremity dysfunction, fall, equilibrium trouble, weight loss, pain, atrophy, activities of daily living impaired and wrong injection technique. On an unknown date, the outcome of the arm paralysis, injection site indentation, injection site bruising, injection site discoloration, injection site pain, frozen shoulder, arm spasticity, injury to ulnar nerve, carpal tunnel syndrome, cubital tunnel syndrome, pain in fingers, numbness in fingers, injected limb mobility decreased, upper extremity dysfunction, fall, equilibrium trouble and pain were not recovered/not resolved and the outcome of the weight loss, atrophy, activities of daily living impaired and wrong injection technique were unknown.   It was unknown if the reporter considered the arm paralysis, injection site indentation, injection site bruising, injection site discoloration, injection site pain, frozen shoulder, arm spasticity, injury to ulnar nerve, carpal tunnel syndrome, cubital tunnel syndrome, pain in fingers, numbness in fingers, injected limb mobility decreased, upper extremity dysfunction, fall, equilibrium trouble, weight loss, pain, atrophy and activities of daily living impaired to be related to Shingrix.     Additional Information: GSK Receipt Date: 30-JAN-2023 Reporter's comments: The reporter was the patient who had received the first dose of Shingrix  and did not receive second dose, due to issues experienced after first dose.  The patient had believed that, the dose was not administered correctly.  She had reported that, the Healthcare Professional (HCP) who administered dose seemed upset and roughly had jabbed her left arm.  She reported that, having very little fat on their arms and believed that the HCP technique may had contributed to the issues which she was still experiencing at the time of reporting. She reported an intense pain at injection site at time of administration. She also reported black and blue bruising at injection site, that varies between the size of a dime and a quarter depending on usage of the left arm.  She reported immediately noticing their left pinky and ring fingers were not responding while typing right after receiving dose, which had never occurred prior to receiving dose.  She reported that, the physical therapist had stated that, she had a frozen shoulder, due to keeling their arm straight for extended period of time due to being unable to bend her arm at the elbow after receiving Shingrix dose. She reported having to wear a sling at night to limit mobility as moving left arm which would cause her to wake up in an excruciating pain. She also reported that, the physical therapist believes that, she had some type of ulnar nerve damage, but no official diagnosis had been made. She reported that, she had x-rays done at two different hospitals, which had ruled out carpal and cubital tunnel syndrome. She also reported that, the physical therapist had stated that, she had a weird/odd left hand movement, which consisted of fingers moving up when she was reach for something, instead of toward the object that she was reaching for. She reported atrophy of left hand and had experienced numbness and pain in the ring and pinky fingers. She reported that, her left arm and hand were basically unusable, resulting in them first taking a year off from work, before having to resign in May of 2022 due to inability to complete job functions. She reported that, she had seen chiropractors and neurologist, to no avail. She reported receiving nerve conduction tests to tried to get the left hand to imitate the right, to no avail. She reported that, she had experienced shoulder pain due to physical therapy exercises that, she must complete to try and addressed the issues with left arm and hand.  She reported that, she had experienced balance issues due to issues with left foot and toes, resulting in patient often tripping and falling. She reported that, she had significant issues with preparing food, resulting in cuts and burns. She also reported that, she had lost 16 pounds in the last year, due to fear of cutting or burning themselves while preparing food.  She reported indentation at injection site. She reported that, she had issues with driving, due to having to navigate vehicle with one hand. The reporter had consented to follow-up. Additional supportive information: The reporter reported belief dose was not administered correctly, which led to wrong injection technique.