This spontaneous case was reported by a consumer and describes the occurrence of ANGINA PECTORIS (pain around her heart/felt like her whole chest was rising up above her body) in a 74-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below. Patient had no medications, food and other products allergies. Concurrent medical conditions included Breast implant user (mentioned having breast implants). On 28-Jan-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 18-Aug-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 01-Apr-2022, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On an unknown date, the patient experienced ANGINA PECTORIS (pain around her heart/felt like her whole chest was rising up above her body) (seriousness criterion medically significant), PAIN IN EXTREMITY (pain/burning feeling/legs and feet started giving her a lot of problems) and CHEST DISCOMFORT (felt like her whole chest was rising up above her body). At the time of the report, ANGINA PECTORIS (pain around her heart/felt like her whole chest was rising up above her body) and CHEST DISCOMFORT (felt like her whole chest was rising up above her body) had not resolved and PAIN IN EXTREMITY (pain/burning feeling/legs and feet started giving her a lot of problems) was resolving. Shortly after her booster vaccination with mRNA-1273 (1-Apr-2022), she noted pain & burning feeling in her legs as well as on & off pain around her heart. Her heart pain persisted for a day in one episode. In another episode, event heart pain was accompanied by a sensation of chest rising above her body. All of her symptoms were ongoing, but her legs have improved. Diabetes pills for her legs was reported. No consultation was done. It was noted that her 2nd dose of mRNA-1273 vaccine was given 7 months after her 1st mRNA-1273 vaccination. She has not tested positive with COVID-19 tests after her vaccination. Company Comment: This spontaneous case concerns a 74-year-old, female patient, with no relevant medical history reported, who experienced an unexpected, medically significant serious event of Angina pectoris shortly after her 3rd COVID-19 vaccination with mRNA-1273 vaccine. Exact onset latency of the event angina pectoris cannot be established with an unknown event's start date. Reportedly, her 2nd dose of mRNA-1273 vaccine was given 7 months after her 1st mRNA-1273 vaccination. Her symptoms began as an on & off pain around her heart that persisted for a day in one occasion, and accompanied with the sensation of chest rising in another episode. Event outcome was ongoing. Patient's age could be a predisposing risk factor to the event Angina pectoris. The benefit-risk relationship of mRNA-1273 is not affected by this report. Event's seriousness assessed based on medical judgement and the available information. This case was linked to MOD-2022-546541 (Patient Link). Sender's Comments: This spontaneous case concerns a 74-year-old, female patient, with no relevant medical history reported, who experienced an unexpected, medically significant serious event of Angina pectoris shortly after her 3rd COVID-19 vaccination with mRNA-1273 vaccine. Exact onset latency of the event angina pectoris cannot be established with an unknown event's start date. Reportedly, her 2nd dose of mRNA-1273 vaccine was given 7 months after her 1st mRNA-1273 vaccination. Her symptoms began as an on & off pain around her heart that persisted for a day in one occasion, and accompanied with the sensation of chest rising in another episode. Event outcome was ongoing. Patient's age could be a predisposing risk factor to the event Angina pectoris. The benefit-risk relationship of mRNA-1273 is not affected by this report. Event's seriousness assessed based on medical judgement and the available information.