got staph in one area of it; biopsy showed eczema; rash which was mostly on her face/ spread to other areas of her body; This is a spontaneous report received from a contactable nurse (patient). A 40-year-old female patient received BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE, lot number EL9265), administered in left arm on 28Jan2021 (at the age of 40-year-old) around same time of first dose reported as in the early afternoon between 2-3 PM as dose 2, single for COVID-19 immunisation. The patient's medical history included hypertension from 2010, anxiety and depression both from 2019. The patient was taking unspecified concomitant medications reported as non-relevant. The patient previously received BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE, lot number EL3246), administered in right arm on 07Jan2021 (at the age of 40-year-old) in the early afternoon between 2-3 PM as dose 1, single for COVID-19 immunisation. The patient experienced eczema on Feb2021 reported as serious with medically significant criteria. Caller was a registered nurse (RN) and she was calling to report her side effects after receiving both doses of the Pfizer COVID-19 vaccine. Caller (nurse) reported that two weeks after her second dose (Feb2021), received on 28Jan2021, she developed a rash which was mostly on her face. The rash then spread to other areas of her body. She saw a dermatologist, the biopsy showed eczema, was worked up for lupus, her antinuclear antibody (ANA) test was positive initially and the second test was negative. She said she was 100% glad she got the vaccine but that it seems strange to suddenly had eczema at her age. She wanted to know if this had been reported by anyone else and wanted to report her symptoms. She said that she didn't have eczema before she got the vaccine but now (unspecified date and time) she did, so she wanted to see if anyone had that experience, not to complain. She clarified she got the Pfizer COVID-19 vaccine, two dose, clarified further to Pfizer-BioNTech COVID-19 vaccine. Caller said it seems like the eczema happened right about then, she had never had it in her life. She said the eczema started a couple weeks after second dose of the vaccine. She said her first dose (lot number EL3246) was given 07Jan2021 in her right arm in the early afternoon between 2-3 PM. She said her second dose was given on 28Jan2021 (lot number EL9265), given around same time of day in her left arm. Caller said that she was taking concomitant medications but nothing relevant (as reported. Caller said that the eczema started two weeks after second dose so in early to mid-Feb2021, and it was still flaring pretty bad. She said she did not have it before and they had just kind of treated it like mask rash on her face then it spread to other areas of her body. She said they had it biopsied and said it was eczema, during May2021. Caller said that she was using steroid creams for treatment pretty much. No further details provided about steroid creams. Caller said all this had not made her anxiety and depression better for sure. Caller said that she would like to know if there were any resources, if people had verbalized having issues with eczema after vaccination. About seriousness caller said to her it was significant, she also got staph in one area of it, this was in May2021, and she had to work, it was very taxing dealing with it for such a long period of time and emotionally going from not having it to having it for months. The outcome of the events was unknown for "got staph in one area of it" and not resolved for all other events.