feeling pain in her arm and it was hard; neck pain; her Carotid Artery is already enlarged; her thyroid there was nodules that was small and now it is big enough; depression; high blood pressure; high cholesterol; This is a spontaneous report received from a non-contactable reporter(s) (Consumer or other non-HCP) from medical information team. The reporter is the patient.  A 69-year-old female patient received bnt162b2 (BNT162B2), administration date 25Oct2021 (Batch/Lot number: unknown) as dose 2, single for covid-19 immunization. The patient's relevant medical history and concomitant medications were not reported. Vaccination history included: Bnt162b2 (Dose 1), administration date: 04Oct2021, for COVID-19 Immunization, reaction(s): "the first vaccine everything was fine, no problems' coded". The following information was reported: PAIN IN EXTREMITY (non-serious) with onset Oct2021, outcome "not recovered", described as "feeling pain in her arm and it was hard"; NECK PAIN (non-serious) with onset 2021, outcome "not recovered", described as "neck pain"; ARTERIAL DISORDER (non-serious) with onset 2021, outcome "unknown", described as "her Carotid Artery is already enlarged"; THYROID MASS (non-serious) with onset 2021, outcome "unknown", described as "her thyroid there was nodules that was small and now it is big enough"; DEPRESSION (non-serious) with onset 2021, outcome "unknown", described as "depression"; HYPERTENSION (non-serious) with onset 2021, outcome "unknown", described as "high blood pressure"; BLOOD CHOLESTEROL INCREASED (non-serious) with onset 2021, outcome "unknown", described as "high cholesterol". The events "feeling pain in her arm and it was hard", "neck pain", "her carotid artery is already enlarged" and "her thyroid there was nodules that was small and now it is big enough" were evaluated at the physician office visit. Relevant laboratory tests and procedures are available in the appropriate section. Therapeutic measures were taken as a result of hypertension, blood cholesterol increased.  Additional information: The patient received first dose on 04Oct2021, and everything was fine, with no problems. Received second dose on 25Oct2021 (three weeks later) and on the second day she started feeling pain in her arm and it was hard and thought that maybe just moved it or something and shake it and it did not go away then later also started experiencing neck pain and thought maybe she slept wrong, and it was not going away either. Also in her neck her Carotid Artery was already enlarged. Therefore, the patient went to the doctors and was suggested for Ultrasound and doctor said that he would like to have an MRI done. The patient was referred to see an ENT to see if there is anything with the throat. Everything was fine with her throat and nodules were noticed in her thyroid which were small and now are big enough and doctor wanted to do a biopsy. Doctor wants to send her to do the CAT scan and additional tests. She was now in a state of depression after this and was unable to leave the house. Also stated that she has high blood pressure and high cholesterol and has to take medication for that.  No follow-up attempts are possible; information about lot/batch number cannot be obtained. No further information is expected.