Headache; Nausea; has exudate, it's white stuff that looks like strep; feel weak; tired; lost her appetite and ate less; felt down; it progressed and she developed more swollen lymph nodes; lymphocytes were up; she was positive for mononucleosis; excessive and thick saliva; excessive and thick saliva; her jaw is sore; tonsils are more swollen; she has a swollen throat and sounds different; feels like her tongue is swollen but it doesn't look swollen; tonsils were swollen; noticed a lump on her neck; swollen lymph node; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP). The reporter is the parent.  A 16 year-old female patient received bnt162b2 (BNT162B2), administered in arm left, administration date 05Mar2022 11:00 (Batch/Lot number: unknown) at the age of 16 years as dose 1, single for covid-19 immunisation. Relevant medical history included: "Autonomic dysfunction" (unspecified if ongoing), notes: Autonomic dysfunction thinks this was diagnosed in 2017, is not sure.; "Tourette's" (unspecified if ongoing); "Anxiety" (unspecified if ongoing). Concomitant medication(s) included: CLONIDINE taken for tourette's disorder; HYDROXYZINE taken for anxiety. The following information was reported: NEOPLASM (non-serious) with onset 10Mar2022, outcome "unknown", described as "noticed a lump on her neck"; LYMPHADENOPATHY (non-serious) with onset 10Mar2022, outcome "unknown", described as "swollen lymph node"; DECREASED APPETITE (non-serious), outcome "unknown", described as "lost her appetite and ate less"; DEPRESSED MOOD (non-serious), outcome "unknown", described as "felt down"; CONDITION AGGRAVATED (non-serious), outcome "unknown", described as "it progressed and she developed more swollen lymph nodes"; TONSILLAR HYPERTROPHY (non-serious) with onset 19Mar2022, outcome "unknown", described as "tonsils were swollen"; HEADACHE (non-serious), outcome "unknown", described as "Headache"; NAUSEA (non-serious), outcome "unknown", described as "Nausea"; FEELING ABNORMAL (non-serious), outcome "unknown", described as "has exudate, it's white stuff that looks like strep"; ASTHENIA (non-serious), outcome "unknown", described as "feel weak"; FATIGUE (non-serious), outcome "unknown", described as "tired"; SALIVA ALTERED (non-serious), SALIVARY HYPERSECRETION (non-serious) all with onset 23Mar2022, outcome "unknown" and all described as "excessive and thick saliva"; PAIN IN JAW (non-serious) with onset 23Mar2022, outcome "unknown", described as "her jaw is sore"; CONDITION AGGRAVATED (non-serious) with onset 23Mar2022, outcome "unknown", described as "tonsils are more swollen"; PHARYNGEAL SWELLING (non-serious) with onset 23Mar2022, outcome "unknown", described as "she has a swollen throat and sounds different"; SWOLLEN TONGUE (non-serious) with onset 23Mar2022, outcome "unknown", described as "feels like her tongue is swollen but it doesn't look swollen"; LYMPHOCYTE COUNT INCREASED (non-serious), outcome "unknown", described as "lymphocytes were up"; INFECTIOUS MONONUCLEOSIS (non-serious), outcome "unknown", described as "she was positive for mononucleosis". The events "noticed a lump on her neck", "swollen lymph node", "lost her appetite and ate less", "felt down", "it progressed and she developed more swollen lymph nodes", "tonsils were swollen", "headache", "nausea", "has exudate, it's white stuff that looks like strep", "feel weak", "tired", "excessive and thick saliva", "excessive and thick saliva", "her jaw is sore", "tonsils are more swollen", "she has a swollen throat and sounds different", "feels like her tongue is swollen but it doesn't look swollen", "lymphocytes were up" and "she was positive for mononucleosis" were evaluated at the physician office visit. Relevant laboratory tests and procedures are available in the appropriate section. Therapeutic measures were taken as a result of neoplasm.  Additional information: Reporter states, her daughter got the vaccine on the 5th and on the 10th noticed a lump on her neck. States then the following week she lost her appetite and ate less and felt down and then it progressed and she developed more swollen lymph nodes and her tonsils were swollen, had a headache, and nausea. States that ultimately her doctor ordered blood testing and her lymphocytes were up and she was positive for mononucleosis. Reporter states she is under the care of her doctor and she said since the lump was on her neck there are no reports of that on the neck but reports of lumps in armpit and breast area, that as far as she was aware there are no reports about lumps on neck, mouth and jawline swelling up or having possible false positive. Patient has the vaccine in her left arm but the first swollen lymph node was kind of the back right side of her actual neck and then under her jawline, all underneath her jawline and her tonsils are swollen huge which makes sense as they are lymph nodes. States she also has exudate, it is white stuff that looks like strep. She got the vaccine on 5Mar2022 noticed the swollen lymph node on 10Mar2022. States then on 15Mar2022 she had a doctor appointment and they said it was swollen lymph node. States she had no other symptoms at the time, everything was good and sounded good. States the whole following week is when she began to lose her appetite and feel weak and on friday 18Mar2022, she called from school said her head was hurting and she was feeling weak and tired and to pick her up and bring her home. States on 19Mar2022 she woke up with her tonsils hugely swollen and she took her to urgent care and found out she had another swollen lymph node under her jaw. Reporter states the anibiotic she was prescribed is doxycycline hyc 100mg, take 1 pill twice a day, orally. States she started on 19Mar2022 and took 4 doses. Reporter states, all of her symptoms are getting worse, she had to send her doctor a message this morning. Reporter states she is reporting excessive and thick saliva, her jaw is sore, her tonsils are more swollen, she has a swollen throat and sounds different, and feels like her tongue is swollen but it doesn't look swollen. Patient visited to physician office for adverse events. The patient had not prior vaccinations within 4 weeks. Adverse events following prior vaccinations states that anytime she gets flu vaccine always gets flu like symptoms other than that not that she recalls. Other medicines Clonidine: started about a year ago and hydroxyzine: she takes when she feels she needs it for anxiety started about 1 year ago.  The lot number for bnt162b2 was not provided and will be requested during follow up.