Itching; Collagen disorder; Muscle disorder; Bone disorder; Skin laxity; This spontaneous case was reported by a consumer and describes the occurrence of COLLAGEN DISORDER (Collagen disorder), MUSCLE DISORDER (Muscle disorder), BONE DISORDER (Bone disorder), SKIN LAXITY (Skin laxity) and PRURITUS (Itching) in a 64-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination.    Co-suspect product included non-company product PANCREATIN (CREON) for Pancreatic cancer.    The patient's past medical history included Tobacco abuse, Alcohol use (ONE GLASS WINE, OCCASIONALLY) and High cholesterol. Concurrent medical conditions included Diabetes mellitus since 2011 and Hypertension in 2011. Concomitant products included AMLODIPINE for Blood pressure high, INSULIN LISPRO (HUMALOG) and INSULIN GLARGINE (TOUJEO) for Diabetes mellitus.   On 16-Apr-2021, the patient started PANCREATIN (CREON) (Oral) 1 capsule with meals/1-2 per snack (36000 Unit,4 in 1 D). On 19-Apr-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 16-May-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. On 25-May-2021, the patient experienced COLLAGEN DISORDER (Collagen disorder), MUSCLE DISORDER (Muscle disorder), BONE DISORDER (Bone disorder) and SKIN LAXITY (Skin laxity). On 02-Aug-2021, the patient experienced PRURITUS (Itching). The last dose administered for PANCREATIN (CREON) was on 02-Aug-2021. At the time of the report, COLLAGEN DISORDER (Collagen disorder), MUSCLE DISORDER (Muscle disorder), BONE DISORDER (Bone disorder), SKIN LAXITY (Skin laxity) and PRURITUS (Itching) had not resolved.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On an unknown date, Electrocardiogram: Normal.         The patient stated she went on the emergency but no medication was given to her. She stated that at the emergency, she did not experience stroke, no heart attack and the facial damage was not considered as Bell's Palsy. She was doing facial exercise but no improvement. She described her condition as if her face loss all the collagen, she had high cheek bones and it was gone. Her face was sliced. She was experienced facial skin a few days after taking her Creon medication and Covid 19 vaccination. She also mentioned that she went to the hospital after she noticed the sagging of her facial skin and an Electrocardiogram was done and the result was normal. Due to the normal result of her electrocardiogram she was told that she did not suffer from stroke or heart attack. To get her face fix she went to consult a cosmetic surgeon and she was advised that she have an option to undergo a facelift procedure or she could have a face filler as a temporary fix that could last for eight months. It was unknown if she was enrolled in a COVID-19 vaccine trial. On 19 Apr 2021, she received 1st dose COVID-19 vaccine manufactured by Moderna. On 16 May 2021 she received 2nd dose COVID-19 vaccine manufactured by Moderna. Treatment information was not provided.  This case was identified as part of a retrospective clean-up activity where certain emails received in the Moderna mailbox were missed to be booked-in.