Rashes all near metal like buttons/where her bra goes; Hypersensitivity to metals; Inflammation of blood test, lab panels abnormal; TMJ dysfunction, teeth feel like breaking because of pressure; Teeth grinding; Teeth feel like they are breaking because of the pressure; Numbness in fingers and toes; Lockjaw; Extreme jaw pain; Tingling in fingers and toes; Heaviness all over; Shortness of breath; Brain fog; This case was reported by a consumer via patient support programs and described the occurrence of numbness in a 37-year-old female patient who received DTPa (Reduced antigen) (Boostrix) (batch number 3P95D, expiry date 6th April 2023) for prophylaxis.   Co-suspect products included dtpa vaccine. pre-filled syringe device (Boostrix Pre-Filled Syringe Device) injection syringe for prophylaxis and COVID-19 VACCINE for prophylaxis.   The patient's past medical history included shoulder pain (had shoulder pain because she had a pinched nerve) and neck pain (had neck pain because she had a pinched nerve).   In June 2021, the patient received Boostrix and Boostrix Pre-Filled Syringe Device. In September 2021, the patient received COVID-19 VACCINE. In July 2021, less than 2 months after receiving Boostrix and Boostrix Pre-Filled Syringe Device, the patient experienced numbness, lockjaw, jaw pain, tingling feet/hands, sensation of heaviness, shortness of breath, foggy feeling in head, temporomandibular joint dysfunction, teeth-grinding and brittle teeth. In August 2021, the patient experienced inflammatory marker increased. On an unknown date, the patient experienced rash and allergy to metals. On an unknown date, the outcome of the numbness, lockjaw, jaw pain, tingling feet/hands, sensation of heaviness, shortness of breath, rash, temporomandibular joint dysfunction, teeth-grinding and brittle teeth were not recovered/not resolved and the outcome of the foggy feeling in head, allergy to metals and inflammatory marker increased were unknown.   It was unknown if the reporter considered the numbness, lockjaw, jaw pain, tingling feet/hands, sensation of heaviness, shortness of breath, foggy feeling in head, rash, allergy to metals, inflammatory marker increased, temporomandibular joint dysfunction, teeth-grinding and brittle teeth to be related to Boostrix and Boostrix Pre-Filled Syringe Device. This report is made by GSK without prejudice and does not imply any admission or liability for the incident or its consequences.  Additional details were provided are as follows: The age at vaccination was not reported. The patient had only pain before the Boostrix, neck pain  and shoulder pain because she has had a pinched nerve. The patient received a dose of Boostrix in her left arm and in July 2021, less than 2 months after receiving vaccination, the patient had lockjaw, numbness and tingling in fingers and toes, heaviness all over, shortness of breath, brain fog and rashes all near metal like buttons/where her bra. In July 2021, 6 weeks after receiving vaccination, the patient experienced symptoms of temporomandibular joint dysfunction, such as teeth grinding and extreme jaw pain. The patient stated that, her teeth felt like they were breaking because of the pressure. On an unknown date, less than 6 months, after receiving vaccination, she had also developed hypersensitivity to metals and rashes. In August 2021 and October 2021, the patient had a lab panels which were abnormal as they showed elevated inflammation in her blood. The patient was inquiring about treatment recommendations or medical guidance. The patient stated that she had been visited to different doctors and no one seems to know what was going on with her, she was pretty sure that it was from the vaccine, she did not take any medications. The patient had no existing health conditions, not had Covid and had first shot of Covid vaccine until September.  Provided medical advice disclaimer. Provided number to department for the caller to provide to health care professional. No additional details were provided by the caller. The reporter consented to follow-up. Note: The patient received the Boostrix vaccine on either 24th June 2021 or 25th June 2021, therefore conservatively partial date was captured.; Sender's Comments:  US-GLAXOSMITHKLINE-US2021252835:Same reporter