hives mostly on arms from shoulder to wrist and palms, chest, stomach; itchy and felt like something was crawling under his skin; itchy and felt like something was crawling under his skin; This is a spontaneous report from a contactable consumer or other non-HCP [patient's mother] who reported for his son.  A 22-year-old male [reporter's son] received first dose of bnt162b2 (PFIZER-BIONTECH COVID-19 VACCINE, Solution for injection, Batch/Lot number was EN6207) via an unspecified route of administration, administered in left arm on Monday, 15Mar2021 at 14:45 (age at the time of vaccination was 22-year-old) as a DOSE 1, SINGLE dose for COVID-19 immunization. Medical history included wisdom tooth was inflamed from an unspecified, dry skin. The patient had no family medical history. Concomitant medications included AMOXICILLIN 500 mg, three times a day, by mouth (oral route) from 08March2021 till 15Mar2021 for indication of wisdom tooth was inflamed. Patient was on the last day, Day 7, the patient was only taking this for a short period of time. The patient had no prior vaccinations within 4 weeks and no adverse events prior to vaccinations. On 17Mar2021, the patient experienced hives mostly on arms from shoulder to wrist and palms, chest, stomach at 07:00 and itchy and felt like something was crawling under his skin. Reporter does not know if the reaction was from the vaccine or not. Patient was totally fine on the day of the vaccine and overnight. On Tuesday evening, reporter stated that her son put some kind of cream on his hands on Tuesday, the cream was a new product for her son, it was his first time using it. Patient has dry skin. On Wednesday 17Mar2021 morning- 38 hours after the vaccine, her son woke up in hives from his shoulder to wrist and on his chest and stomach. Reporter clarified on Wednesday, her son had much less on the chest and stomach, but still had it on his arms. She reiterated she doesn't know if her son's reaction was from the cream or the vaccine. She clarified there was nothing around the injection site; this was not a local reaction, it was even less on the injection site arm. Course of symptoms: On Wednesday, patient was itchy and felt like something was crawling under his skin; on Thursday it was about the same and patient took an antihistamine; on Friday it lightened up and it was less itchy; on Saturday it was much better; and on Sunday the hives were gone. She reports they blame the cream, but just wanted to make sure. Reporter stated that she herself just finished her two shots and had nothing. She reports her son was scheduled for his second shot and wanted to know if it was common to have such a reaction, if it was even from the shot, is he going to be okay taking the second shot. She reports she thought her son might need to see an allergist to rule out the cream and to make sure he's not allergic to any ingredients in the vaccine. Reporter clarified her son still wants to get the second shot. She mentioned her son put some cream on [unspecified], her son knew the cream, she described it was 2 creams, he put like anti pimple mask, HA DHA chemicals acetic she did not knew what it was, but put it on his face against acne from Ulta, on his face and it started burning. Reporter stated that her son then washed his face and put on a different cream. She reports her son also put some cream on his arms. She suspects her son had some on his fingers of the cream or face mask and she doesn't knew if he washed it thoroughly. Reporter stated that maybe some of the chemicals were on her son's fingers. They really don't know, maybe her son could take the cream to an allergist and do a test or even do it at home. She reports her and her son want to get the vaccine or the face mask/cream ruled out before the second shot. She reported her son was scheduled to receive the second dose 28 days later on 12Apr2021. She stated that her son was upset that it was not 21 days later and says it was not MODERNA, it needs to be 21 days after the first dose. She reports that if her son was okay, she will call them and try to schedule it for earlier. She states that the (withheld) just schedules everyone for 28 days. She clarified that her son was not allergic to anything, that she knew of. She reports her son said the hives were gone. She mentioned she had tons of pictures of the hives. She reports the hives were mostly on her son's arms and even on his palms, they were everywhere. She mentioned that her son doesn't want to go to the doctor. She wanted to knew if her son's reaction could be a warning that he's going to have a severe reaction to the second dose. She reiterates that she doubts it was from the vaccine, but she just wanted to call to be safe. She reports she had been reading everywhere, from the CDC, and she believed that this rash was not really from the vaccine because there was nothing around the injection site. Caller wants to know if this is going to propriety information or publicly known. While probing for relevant tests, caller mentions she has pictures of her son's arms and she can send the pictures if needed. She wanted to know what they should do about the time frame : should they push it to 21 days; should her son even have the second shot. The patient used Benadryl, Allegra, and Loratadine or something an antihistamine as a treatment drug for the adverse events. No relevant tests were done. The clinical outcome of hives mostly on arms from shoulder to wrist and palms, chest, stomach was recovered on 21Mar2021, while the clinical outcome of itchy and felt like something was crawling under his skin was unknown.  No follow-up attempts are possible. No further information is expected.