absolute eosinophil extremely high; she also had fatigue for about 48 hours after getting the vaccine then it got better; After the 2nd vaccine she a had slightly sore arm; This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP). The reporter is the patient.  A 62 year-old female patient received bnt162b2 (BNT162B2, Solution for injection), administered in arm left, administration date 17Feb2021 (Lot number: EN6200) at the age of 62 years as dose 2, single for covid-19 immunisation. Relevant medical history included: "blood pressure issues" (unspecified if ongoing), notes: Verbatim: blood pressure issues; "cholesterol" (unspecified if ongoing), notes: Verbatim: cholesterol issues; "Islet cell transplant", start date: 2008 (unspecified if ongoing), notes: Verbatim: Islet cell transplant; "Immunosuppressant drug for her transplant" (unspecified if ongoing), notes: Verbatim: Immunosuppressant drug for her transplant; "Immunosuppressant" (unspecified if ongoing), notes: Verbatim: Immunosuppressant; "Diabetes" (unspecified if ongoing), notes: Verbatim: Diabetes; "blood pressure" (unspecified if ongoing), notes: Verbatim: blood pressure; "Allergies" (unspecified if ongoing), notes: Verbatim: Allergies. Concomitant medication(s) included: ZORTRESS; JANUVIA [SITAGLIPTIN PHOSPHATE] taken for diabetes mellitus, start date: 2008; LOSARTAN; ALLERCLEAR; TACROLIMUS. The following information was reported: EOSINOPHIL COUNT INCREASED (non-serious), outcome "unknown", described as "absolute eosinophil extremely high"; FATIGUE (non-serious), outcome "unknown", described as "she also had fatigue for about 48 hours after getting the vaccine then it got better"; PAIN IN EXTREMITY (non-serious), outcome "unknown", described as "After the 2nd vaccine she a had slightly sore arm". Relevant laboratory tests and procedures are available in the appropriate section.  Additional information: She had the 2nd Pfizer COVID vaccine on 17Feb. Last Monday she went in for routine, every 6 month, blood work and when she got her results she found her absolute eosinophil came back as extremely high, normal is 500 but, hers was 3809. Never had been this high before. She has never had her white blood cell count like this. She doesn't know if its related to the COVID vaccine but, if it is, she just wanted to call and report it, just in case it is because of the vaccine. She is a diabetic, she is immunocompromised, she had a transplant in the past, she is immunosuppressed. Diabetes started before she got vaccine had she has had this since she was 13. Consumer reports that she had an Islet cell transplant that  functionally cured her of diabetes, and she is off insulin. This occurred back in around 2008 but, she will be on immunosuppressants the rest of her life. With her white blood cell count being that high she knows that she believes it does something to your DNA or RNA. She wants to know if there have been any other reports of this issue she is reporting? She went on 22Mar this year for blood work and got results on 26Mar. She saw the doctor on Monday, yesterday, and is being referred to another doctor. She wanted to reports this so if this is an ongoing report Pfizer needs to change this. Absolute Eosinophil extreme high outcome and treatment: She assumes the eosinophil level is still going on, she is going to see an allergist today to see if it is her allergies but, she is calling to report this just in case it is the vaccine. After the 2nd vaccine she a had slightly sore arm but, it didn't hurt as much as the first. It went away after the 1st day of getting the vaccine and she also had fatigue for about 48 hours after getting the vaccine then it got better. She has Hyponatremia, which caller says is low blood pressure, where she will have to sit down or she will pass out. So now, she has both Hypertension and Hypotension. In 2017, she had an episode of hypotension with syncope, and broke her tibia and fibula in her right leg after she passed out. Reports having quiet a medical history and we would be here all day with that. She did not have high cholesterol until after her transplant but, she was on simvastatin but had to take herself off of that because of the side effects: Had severe calf cramping in the middle of the night and major fatigue, not sure of the dates of the events having calf cramping but, she had them every night when she was taking it. Since going off the medication the cramping is gone. She still has fatigue sometimes because of the drugs she is on but, the cramping is gone. Fatigue started before getting the COVID vaccine and the calf cramping. Only thing she has noticed on her blood work that is a big issue is the eosinophils. She does not want to provide any other details about this report on blood work.  No follow-up attempts are possible. No further information is expected.