hunger pain; loss of appetite or a gain of appetite; This is a spontaneous report received from a contactable other hcp (Patient). A 65-year-old female patient received first dose of BNT162B2 (PFIZER BIONTECH COVID-19 VACCINE, solution for injection, Batch/Lot Number: EL1283), via an unspecified route of administration on 26Jan2021 (at the age of 65-year-old) as single dose for COVID-19 immunisation. Medical history included cystitis interstitial, ongoing gastrooesophageal reflux disease, hypothyroidism, underactive thyroid. Concomitant medications included melatonin taken for insomnia, rabeprazole taken for gastrooesophageal reflux disease, levothyroxine sodium (SYNTHROID) taken for hypothyroidism, cystitis interstitial (not taking anything, just go to the clinic every four months or so hypoallergenic installation so there was no over the counter medication). On an unspecified date in 2021, the patient experienced hunger pain and loss of appetite or a gain of appetite. Patient received both doses of the PFIZER-BIONTECH COVID-19 VACCINE, 1st dose was given 26Jan2021 and 2nd dose was 16Feb2021. She was checking if there are reported cases of increased or decreased appetite after having the shot of the vaccine. On 02Jan2021 she had gastritis and took iron polypeptide pill. She was not sure when her hunger pain started if it was when she received the 1st shot or prior to it. Patient did not know for sure yet weather her symptoms were due to the COVID-19 vaccine or not but she had rather some rare cases of vaccine can cause either the loss of appetite or a gain of appetite and She tried to figure out why when she rarely ever felt hungry in her adult life for the last three and a half months or so she just always felt, almost felt hungry. She looked onto all possibilities and then was always eating; she had this disability for 30 years it was really limited her diet so she was always eating the same thing all the time so that did not change. The only change was where she had been on melatonin to help her sleep for about two and a half months prior to all, always felt starved. She learnt that melatonin affects the hormone that suppress or increase appetite and the only other change was that she got the Pfizer vaccine on 26Jan2021 and the hunger pangs started around that time, but she cannot access her medical records right now because script health had a cyber-attack and their system had been down for month, so she could not precisely go back to her records. She wanted to ask if any of these reported side effects of either loss of appetite or increased appetite. She wondered; some ongoing symptoms were due to vaccine based on some information she read online about weird side effects. He did not know. She was just trying to find out if anyone at Pfizer has heard reports about loss of appetite or increase of appetite after getting mRNA COVID Vaccine. Events were improving and again they were increasing, and she also read that exercise could affect the hormones that increase or suppress appetite. Treatment for the events, she stated, nothing yet just living on oatmeal, milk and water for almost five months with no end inside. Patient received second dose of BNT162B2 (PFIZER BIONTECH COVID-19 VACCINE, Batch/Lot Number: EN5318), via an unspecified route of administration on 16Feb2021 as single dose for COVID-19 immunisation. The outcome of events was unknown.   Information on Lot/Batch number was available. Additional information has been requested.