Not feeling himself; A little tired; Headache; low grade fever; slight chills; night sweats; burning sensation upper portion of the groin area, accidental exposure to pepper spray; light rash in upper groin area; slight redness in the upper groin area; burning sensation in thumb joint; burning sensation in nose when they exhale; burning sensation in mouth; faint sensation; This case was reported by a consumer via call center representative and described the occurrence of fever in a 59-year-old male patient who received Herpes zoster (Shingrix) for prophylaxis.   On 19th November 2022, the patient received the 2nd dose of Shingrix. In November 2022, 61 hrs after receiving Shingrix, the patient experienced burning sensation, rash, erythema, burning sensation in joints, nasal burning, burning oral sensation and felt faint. On 19th November 2022, the patient experienced fever, chills and night sweat. On 20th November 2022, the patient experienced feeling abnormal, fatigue and headache. On 21st November 2022, the outcome of the fever, chills and night sweat were recovered/resolved. On an unknown date, the outcome of the burning sensation, burning sensation in joints, nasal burning and burning oral sensation were recovering/resolving and the outcome of the rash and erythema were recovered/resolved and the outcome of the felt faint, feeling abnormal, fatigue and headache were unknown.   It was unknown if the reporter considered the fever, chills, night sweat, rash, erythema, felt faint, feeling abnormal, fatigue and headache to be related to Shingrix. The reporter considered the burning sensation, burning sensation in joints, nasal burning and burning oral sensation to be unrelated to Shingrix.     Additional Information: GSK Receipt Date: 22-Nov-2022 and 23-Nov-2022 Reporter's Comment:  The reporter stated that receiving second dose of Shingrix on 19th November 2022, in the left arm.  The patient was experiencing a low grade fever, slight chills and night sweats shortly after receiving dose.  The reporter stated that the fever, chills, and night sweats resolved as of last night, on 21th November 2022.  The reporter stated experiencing a burning sensation approximately 61 hours after receiving dose, which started in the upper portion of the groin area.  The patient reported also saw a light rash and slight redness in the upper groin area, after onset of the burning sensation.  The patient reported sensation as feeling as though they'd touched a pepper or pepper spray and then touched the area, producing a burning sensation.  The patient reported sensation spread from the upper groin area to their right thumb joint, mouth and nose.  The reporter mentioned burning sensation in all areas was ongoing, but had lessened since onset to a faint sensation.  The patient also reported the burning sensation around the nose was felt primarily when they exhale.  The patient reported light rash and slight redness in the upper groin area has subsided. The Patient states that the next day, he was not feeling himself, he was a little tired and had a headache in addition to the symptoms previously reported in iniital safety report (night sweats and fever).  The patient also provide additional information related to the burning sensation described in the initial AE report.  The patient stated he has no doubt at all that accidental exposure to pepper spray was the cause of the burning sensation described in the initial safety report.  The patient states he works in state prison and carries pepper spray in his pants pocket.  The reporter mentioned states when he got home, he noticed that the pepper spray bottle misfired while in his pocket and he could see a brownish pepper spray spot on his underwear and on his pants where the bottle was kept.  The patient states all his symptoms were typical of pepper spray exposure and was nothing to do with the Shingrix vaccine. The reporter gave consent to follow up.