Booster Dose; Then after the booster dose, she had a more robust reaction which kept her in bed for 4 days.; Then after the booster dose, she had a more robust reaction which kept her in bed for 4 days.; kept her in bed for 4 days; This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP) from medical information team for a Pfizer sponsored program. The reporter is the patient.  A 53 year-old female patient received bnt162b2 (BNT162B2), administration date Aug2021 (Batch/Lot number: unknown) at the age of 53 years as dose 3 (booster), single for covid-19 immunisation. Relevant medical history included: "Immunocompromised" (unspecified if ongoing), notes: immuno-compromised and immune system is weak; "she is allergic to 40 different medications/She said she can't take antibiotics or over-the-counter medications" (unspecified if ongoing), "autoimmune disorder" (unspecified if ongoing), notes: had an autoimmune disorder for 20 years. The patient's concomitant medications were not reported. Past drug history included: Humera, notes: Humera which is a medication that uses a tumor necrotizing factor; Methotrexate; Prednisone; Paltz; Naproxen sodium, reaction(s): "pestle blisters", notes: "pestle blisters" all over her body; Naproxen sodium, reaction(s): "Flushing". Vaccination history included: Bnt162b2 (Dose 1, Single), administration date: Apr2021, when the patient was 53 years old, for COVID-19 Immunization, reaction(s): "Headache", "Sore arm", "she said she had fever"; Bnt162b2 (Dose 2, Single), administration date: May2021, when the patient was 53 years old, for COVID-19 Immunization, reaction(s): "she was in bed for a day", "had more body aches".  The following information was reported: IMMUNISATION (non-serious) with onset Aug2021, outcome "unknown", described as "Booster Dose"; ROBUST TAKE FOLLOWING EXPOSURE TO VACCINIA VIRUS (non-serious) with onset 2021, outcome "not recovered", LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (non-serious) with onset 2021, outcome "unknown" and all described as "Then after the booster dose, she had a more robust reaction which kept her in bed for 4 days."; BEDRIDDEN (non-serious) with onset 2021, outcome "recovered" (2021), described as "kept her in bed for 4 days".  Additional information: The patient said she took the initial 2 shots, but it made her feel sick so she did not take the 2nd months of treatment. She did not tolerate and get along with the medication very well. She said that on 20Feb2022, it will already be 6 months from her 1st booster dose. She said that if the study holds true, then she was looking on a declining immunity of the vaccine, and will most likely have a decreased immunity. She said she was part of the 1st group of people who first received the booster dose. She said there are no guidelines anywhere for people like her who cannot get sick because they "would be shooting in the dark with monoclonal antibodies." She said she does not know if she was going to have sufficient antibodies left to fight the delta, omicron, or other future variants 6 months after her 1st booster dose. With that, consumer wants to know the status of a 2nd booster dose for people who are immunocompromised. She wants to know how she can get a 2nd booster dose. She said she was worried that "normal" people who have received the booster dose might have a declining immunity after 6 months, and may possibly give her one of the variants. And it was informed the consumer that Pfizer has no information on the status of a 2nd booster dose of the Pfizer-BioNTech Covid-19 Vaccine. Consumer wants to know if Pfizer was conducting a study about a 2nd booster dose for immunocompromised people. She also wants to know how she can participate in this study. Consumer wants to know if getting an antibody test is the 1st step she should take. The CDC states that antibody testing was not recommended to determine if a person was immune to SARS-CoV-2 [the virus that causes COVID-19] following COVID-19 vaccination because the usefulness of these tests in vaccinated people has not been established. In addition, antibody tests currently authorized under an EUA are not authorized to determine immune responses in vaccinated people. She had just minimal reactions to the booster dose. Nothing out of the ordinary.   The lot number for bnt162b2 was not provided and will be requested during follow up