hip and knee started getting more sore, difficulty walking and Limping (Arthritis aggravated); This is a spontaneous report received from a contactable consumer (patient), who is a retired Registered Nurse. A 72-year-old female patient received the first dose of BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE, formulation: Solution for injection, lot number: EN6203) via an unspecified route of administration in the left arm on 21Mar2021 (at the age of 72-year-old) about 11:00 as a single dose for COVID-19 immunization. Medical history included patient was diagnosed with arthritis in knee initially back in 1996 when had an injury. Patient was on treadmill and didn't warm up properly and had a torn posterior horn of meniscus in right knee. A knee arthroscopy found patient had torn the posterior horn of meniscus and found arthritis. Patient reports her hip and back arthritis have been since 2015/2016 when Patient had bone density and that's when they picked that up and had knee arthritis for a long time. High blood pressure (diagnosed with back in 1994/1995 roughly, when 46 years old, runs in family). Patient lost weight (lost two years ago next month, lost about 38lbs), mild Asthma (asthma attack when 27 years old, diagnosed with in 1975), Reflux Disease (diagnosed about 6-8 years ago). Concomitant medications included Meloxicam medication (has taken it on 04Apr2021, 05Apr2021 and 06Apr2021) she would stop taking her Meloxicam, amlodipine besilate (NORVASC) at a dose of 10 mg daily for high blood pressure, hydrochlorothiazide HCTZ at a dose of 12.5 mg, once daily for boost the Norvasc, high blood pressure and diuretic, gives boost to high blood pressure medicine, on lowest dose), Omeprazol (PROTONIX) at a dose of 40 mg daily for Stomach (all three drugs started probably 8-10 years), famotidine (PEPCID) at a dose of 40 mg daily (at bedtime) (has only been on for three years), salbutamol (ALBUTEROL) 1-2 puffs as needed for wheezing (since 27 years old and only takes when sick, if has cold or sinus infection, if had strep throat, takes to back her up), fluticasone propionate (FLOVENT) for Asthma at a dose of 44 mcg once daily (one puff) (10-12 years). Patient prior vaccinations included a flu shot back in sept of 2020. Reports she had both Pneumonia and shingles vaccines but nothing within the four weeks of the Pfizer Covid Vaccine. Family Medical History included both the patient late mother and late grandmother had high blood pressure and mother deceased (2016) and Dad passed away in 2003. Patient reported that she was on prescription anti-inflammatory medication for a long time (Meloxicam 7.5mg twice a day, she has been on it for two or three years now) and did not took the anti-inflammatory medication for two weeks after her first dose Pfizer Covid Vaccine due to which her knee and hip are started getting more sore and had difficulty walking, limping, (reported it as probably about 3-4 days after receiving the first dose of Pfizer Covid Vaccine) and always had mild discomfort but it is tolerable and doesn't effect activities of daily living, she was able to do what she has to do. Patient was a dog walker, walking dogs, goes to the market and shopping, doesn't affect her daily activities. Patient took tylenol and one of those topical rubs(it does help, applies it to her right knee and right hip in the morning). Patient enquired whether there would be interactions with Meloxicam and the vaccine. Outcome for the event was recovering. Patient was scheduled for second dose on 11Apr2021.  No follow-up attempts are needed. No further information is expected.