severe inflammatory pain in my hands, wrists, forearms; debilitating nausea; muscle spasms in my right arm; extreme fatigue; IGG level is critically low; desperate; i cannot work; This is a spontaneous report received from contactable reporter (Other HCP). The reporter is the patient.  A 51-year-old female patient (not pregnant) received BNT162b2 (Pfizer-BioNTech COVID-19), as dose 3 (booster), single (Batch/Lot number: unknown) at the age of 51 years for covid-19 immunisation. The patient's relevant medical history included: "avascular necrosis" (unspecified if ongoing). Concomitant medication(s) included: OXYCODONE. Vaccination history included: BNT162b2 (Lot number=EJ1686, Administration date=04Jan2021, Administration_time=09:30 AM, Dose number=1, Vaccine location=Left arm), administration date: 04Jan2021, when the patient was 51-year-old, for Covid-19 immunization, reaction(s): "Severe nausea", "Headache", "Sore throat", "Sweating", "Chills", "Vaccination site pain", "Chest pain", "Shaking of hands"; BNT162b2 (Dose: 2), administration date: 26Jan2021, when the patient was 51-year-old, for Covid-19 immunization, reaction(s): "severe inflammatory pain in my hands, wrists, forearms", "debilitating nausea", "muscle spasms in my right arm", "extreme fatigue", "IGG level is critically low", "desperate", "i cannot work". The following information was reported: INFLAMMATORY PAIN (non-serious), outcome "not recovered", described as "severe inflammatory pain in my hands, wrists, forearms"; NAUSEA (non-serious), outcome "not recovered", described as "debilitating nausea"; MUSCLE SPASMS (non-serious), outcome "not recovered", described as "muscle spasms in my right arm"; FATIGUE (non-serious), outcome "not recovered", described as "extreme fatigue"; BLOOD IMMUNOGLOBULIN G DECREASED (non-serious), outcome "not recovered", described as "IGG level is critically low"; FEELING ABNORMAL (non-serious), outcome "not recovered", described as "desperate"; IMPAIRED WORK ABILITY (non-serious), outcome "not recovered", described as "i cannot work". The events "severe inflammatory pain in my hands, wrists, forearms", "debilitating nausea", "muscle spasms in my right arm", "extreme fatigue", "igg level is critically low", "desperate" and "i cannot work" required physician office visit and emergency room visit. Relevant laboratory tests and procedures are available in the appropriate section. Therapeutic measures were not taken as a result of inflammatory pain, nausea, muscle spasms, fatigue, blood immunoglobulin g decreased, feeling abnormal, impaired work ability. Additional information: Patient had no known allergies. Patient had not been diagnosed with COVID-19 prior to vaccination. Since patient second vaccine 26Jan2021 and subsequently, her booster, she have experienced severe inflammatory pain in her hands, wrists, forearms. debilitating nausea, muscle spasms in her right arm, extreme fatigue to name a few she have seen every discipline possible. Orthopedist, Rheumatologist, Neurologist, immunologist no one can account for her debilitating symptoms that started right after my 2nd vaccine. she IGG level is critically low, but the Immunologist thinks her symptoms are not related. she was desperate she cannot work.  The information on the batch/lot number for BNT162b2 has been requested and will be submitted if and when received.