I had chest pain/It felt like I was having heart attack; severe shortness of breath/It felt like I was having heart attack; I was absolutely exhausted/I get so tired; This spontaneous case was reported by a consumer and describes the occurrence of CHEST PAIN (I had chest pain/It felt like I was having heart attack), DYSPNOEA (severe shortness of breath/It felt like I was having heart attack) and FATIGUE (I was absolutely exhausted/I get so tired) in a 78-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch no. 027A21A) for COVID-19 vaccination.     The patient's past medical history included Polio (As child, I had polio.), Lymphedema (Have lymphedema in left arm from breast cancer in1995) in 1995, Kidney disorder (kidneys problems) and Breast cancer in 1995.    On 06-Mar-2021, the patient received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 07-Mar-2021, the patient experienced CHEST PAIN (I had chest pain/It felt like I was having heart attack) (seriousness criteria hospitalization and medically significant). 07-Mar-2021, the patient experienced DYSPNOEA (severe shortness of breath/It felt like I was having heart attack) (seriousness criteria hospitalization and medically significant). On 08-Mar-2021, the patient experienced FATIGUE (I was absolutely exhausted/I get so tired) (seriousness criterion medically significant). The patient was hospitalized from 07-Mar-2021 to 08-Mar-2021 due to CHEST PAIN and DYSPNOEA. The patient was treated with GLYCERYL TRINITRATE (NITRO [GLYCERYL TRINITRATE]) from 07-Mar-2021 to 08-Mar-2021 for Adverse event, at a dose of 1 DF once a day. At the time of the report, CHEST PAIN (I had chest pain/It felt like I was having heart attack) outcome was unknown, DYSPNOEA (severe shortness of breath/It felt like I was having heart attack) was resolving and FATIGUE (I was absolutely exhausted/I get so tired) had not resolved.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On 09-Mar-2021, Cardiac stress test: heart was doing very well (normal) heart was doing very well. On 25-Mar-2021, Stress echocardiogram: heart was doing very well (normal) heart was doing very well.     For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown), the reporter did not provide any causality assessments.   Concomitant product use was not provided by the reporter.  The patient states that "They did a Covid test on me about 2 times while in the hospital". No results were provided. The patient visited Pulmonologist on 4Apr2021, 27May2021 and 08-SEP-2021. On 08-SEP-2021 bunch of tests. Patient lungs looked very good. All the tests showed that my lungs were fine.  Company Comment: This case concerns a 78 year-old female patient, with relevant history of polio and breast cancer, who experienced the unexpected events of CHEST PAIN, DYSPNOEA and FATIGUE. Events of chest pain and dyspnoea occurred 1 day after the second dose of Spikevax. The event of fatigue occurred 2 days after the second dose of Spikevax. The medical history of polio and breast cancer and the negative rechallenge remain as confounders. The benefit-risk relation of Spikevax is not affected by this report.   This case was linked to MOD-2021-320739 (Patient Link).; Sender's Comments: This case concerns a 78 year-old female patient, with relevant history of polio and breast cancer, who experienced the unexpected events of CHEST PAIN, DYSPNOEA and FATIGUE. Events of chest pain and dyspnoea occurred 1 day after the second dose of Spikevax. The event of fatigue occurred 2 days after the second dose of Spikevax. The medical history of polio and breast cancer and the negative rechallenge remain as confounders. The benefit-risk relation of Spikevax is not affected by this report.