Tested negative 5 days after taking Paxlovid and felt better. Started getting low grade fever and tested positive again within 2 days of finishing prescription. Tested negative 5 days after taking Paxlovid and felt better. Started getting low grade fever and tested positive again within 2 days of finishing prescription. This spontaneous case was reported by a consumer and describes the occurrence of the second episode of COVID-19 (Tested negative 5 days after taking Paxlovid and felt better. Started getting low grade fever and tested positive again within 2 days of finishing prescription.) and the first episode of COVID-19 (Tested negative 5 days after taking Paxlovid and felt better. Started getting low grade fever and tested positive again within 2 days of finishing prescription.) in a  patient of an unknown age and gender who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination.     Concurrent medical conditions included Ulcerative colitis and Drug allergy (unspecified drug).    On 03-Nov-2021, the patient received dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 06-May-2022 at 12:00 PM, the patient experienced the first episode of COVID-19 (Tested negative 5 days after taking Paxlovid and felt better. Started getting low grade fever and tested positive again within 2 days of finishing prescription.). On an unknown date, the patient experienced the second episode of COVID-19 (Tested negative 5 days after taking Paxlovid and felt better. Started getting low grade fever and tested positive again within 2 days of finishing prescription.). The patient was treated with NIRMATRELVIR, RITONAVIR (PAXLOVID) from 27-Apr-2022 to 08-May-2022 for COVID-19 treatment, at an unspecified dose and frequency. In May 2022, last episode of COVID-19 (Tested negative 5 days after taking Paxlovid and felt better. Started getting low grade fever and tested positive again within 2 days of finishing prescription.) had resolved.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On 06-May-2022, SARS-CoV-2 test: positive Positive. In May 2022, SARS-CoV-2 test: negative Tested negative 5 days after taking Paxlovid and felt better. On an unknown date, SARS-CoV-2 test: positive Positive.         The patient previously received a COVID-19 Vaccine. Company comment This spontaneous case concerns a patient of an unknown age and gender, with medical history of Ulcerative colitis, who experienced the unexpected non-serious of COVID-19, which occurred approximately 6 months after receiving a dose of mRNA-1273 vaccine (unknown number and schedule). It was reported that patient tested negative 5 days after taking Paxlovid (nirmatrelvir, ritonavir, prescribed for COVID19 infection) and felt better. Patient started getting low grade fever and tested positive again within 2 days of finishing prescription. No further information was disclosed. The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report.; Sender's Comments: This spontaneous case concerns a patient of an unknown age and gender, with medical history of Ulcerative colitis, who experienced the unexpected non-serious of COVID-19, which occurred approximately 6 months after receiving a dose of mRNA-1273 vaccine (unknown number and schedule). It was reported that patient tested negative 5 days after taking Paxlovid (nirmatrelvir, ritonavir, prescribed for COVID19 infection) and felt better. Patient started getting low grade fever and tested positive again within 2 days of finishing prescription. No further information was disclosed. The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report.