Partially paralyzed; Incoherent, Couldn't answer questions appropriately; This spontaneous case was reported by a consumer and describes the occurrence of PARALYSIS (Partially paralyzed) and INCOHERENT (Incoherent, Couldn't answer questions appropriately) in a 51-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination.     The patient's past medical history included Breast cancer, Anxiety, Cane user (Cane use) and Walker user (Walker use). Concurrent medical conditions included Multiple sclerosis, Systemic lupus erythematosus (Lupus), Depression, Lymphedema, Fibromyalgia and Relapsing-remitting multiple sclerosis (Secondary Relapsing Remitting Multiple Sclerosis). Concomitant products included OCRELIZUMAB (OCREVUS) for an unknown indication.    In March 2021, the patient received dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. In June 2021, the patient experienced PARALYSIS (Partially paralyzed) (seriousness criterion medically significant) and INCOHERENT (Incoherent, Couldn't answer questions appropriately) (seriousness criterion medically significant). At the time of the report, PARALYSIS (Partially paralyzed) and INCOHERENT (Incoherent, Couldn't answer questions appropriately) had resolved.        The action taken with mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown) was unknown.       Treatment medication were not provided.  Company Comment: This spontaneous case concerns a 51-year-old, female patient, with the past medical history of lupus, fibromyalgia, depression & anxiety, and a concurrent condition of secondary relapsing-remitting multiple sclerosis, who experienced an unexpected, medically significant serious events of Paralysis & Incoherent approximately 3 months post-vaccination with a dose of mRNA-1273 vaccine. Patient described her events as partial paralysis, incoherent and couldn't answer questions appropriately. All the events have resolved. Details on the medical history, clinical course, diagnostics, & treatments were not reported. History of depression and anxiety and her concurrent condition of secondary relapsing-remitting multiple sclerosis could be contributory factors to the event incoherent, whereas lupus and fibromyalgia could be considered as predisposing risk factors to the event paralysis. The benefit-risk relationship of mRNA-1273 is not affected by this report. Events' seriousness assessed based on medical judgment.; Sender's Comments: This spontaneous case concerns a 51-year-old, female patient, with the past medical history of lupus, fibromyalgia, depression & anxiety, and a concurrent condition of secondary relapsing-remitting multiple sclerosis, who experienced an unexpected, medically significant serious events of Paralysis & Incoherent approximately 3 months post-vaccination with a dose of mRNA-1273 vaccine. Patient described her events as partial paralysis, incoherent and couldn't answer questions appropriately. All the events have resolved. Details on the medical history, clinical course, diagnostics, & treatments were not reported. History of depression and anxiety and her concurrent condition of secondary relapsing-remitting multiple sclerosis could be contributory factors to the event incoherent, whereas lupus and fibromyalgia could be considered as predisposing risk factors to the event paralysis. The benefit-risk relationship of mRNA-1273 is not affected by this report. Events' seriousness assessed based on medical judgment.