severe stomach cramps/had irritation on his stomach; he lost half his body weight, and he has zero fat in his body,and he went from weighting  220 pounds down to 160 pounds; no appetite; This spontaneous case was reported by a patient and describes the occurrence of ABDOMINAL PAIN UPPER (severe stomach cramps/had irritation on his stomach) in a 65-year-old male patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 011A21A, 018E21a, 017F21A and 049L21A.) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     The patient's past medical history included Bypass surgery in 2015, Gastric bypass in 2021 and Flu vaccination. Concurrent medical conditions included Drug allergy (morphine allergy, Not steroidal Inflammatory) and Heart disease, unspecified (status worsening) since 2015. Concomitant products included DRONABINOL for Appetite stimulated, PANCRELIPASE, METOPROLOL SUCCINATE, OXYBUTYNIN, GABAPENTIN and LORATADINE (LORATAN) for an unknown indication.   On 26-Feb-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 26-Mar-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 12-Nov-2021, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 09-May-2022, received fourth dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. In 2021, the patient experienced ABDOMINAL PAIN UPPER (severe stomach cramps/had irritation on his stomach) (seriousness criterion hospitalization), WEIGHT DECREASED (he lost half his body weight, and he has zero fat in his body,and he went from weighting  220 pounds down to 160 pounds) and DECREASED APPETITE (no appetite). At the time of the report, ABDOMINAL PAIN UPPER (severe stomach cramps/had irritation on his stomach), WEIGHT DECREASED (he lost half his body weight, and he has zero fat in his body,and he went from weighting  220 pounds down to 160 pounds) and DECREASED APPETITE (no appetite) outcome was unknown.        For mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular), the reporter did not provide any causality assessments.   The patient was on unknown medication for concurrent condition of blood pressure. The patient height was given as 6 foot inches. After patient took the first Moderna shot and had irritation on his stomach, he had gastric bypass anyway and they thought that it was normal, but he lost half his body weight, and he has zero fat in his body, none of his doctors can find out what is wrong with him, and the patient went from weighting 220 pounds down to 160 pounds. Also, he had severe stomach cramps, no appetite, and has been treated with TCH for cancer patient to make him eat. It was also reported that patient went to hospital, and stay overnight and received pain medication for stomach cramps.  Company Comment: This spontaneous case concerns a 65-year-old male patient with a history of Gastric bypass, who experienced the unexpected, serious (hospitalization) event of Abdominal pain upper and non-serious events of Weight decreased and Decreased appetite unspecified day after the first dose of mRNA-1273 vaccination. Patient had irritation of his stomach with severe stomach cramps, decreased in appetite and weight loss. He lost his weight from 220 pounds down to 160 pounds. He's been treated with TCH (dronabinol) to increase the appetite. The outcome of the events reported as unknown. Patients medical history of Gastric bypass could be confounder for the events. The benefit-risk relationship of the mRNA-1273 vaccine is not affected by this report.; Sender's Comments: This spontaneous case concerns a 65-year-old male patient with a history of Gastric bypass, who experienced the unexpected, serious (hospitalization) event of Abdominal pain upper and non-serious events of Weight decreased and Decreased appetite unspecified day after the first dose of mRNA-1273 vaccination. Patient had irritation of his stomach with severe stomach cramps, decreased in appetite and weight loss. He lost his weight from 220 pounds down to 160 pounds. He's been treated with TCH (dronabinol) to increase the appetite. The outcome of the events reported as unknown. Patients medical history of Gastric bypass could be confounder for the events. The benefit-risk relationship of the mRNA-1273 vaccine is not affected by this report.