feeling that her throat was closing up; I had the sensation my throat was getting sore; I couldn't swallow; CVID (Common variable immunodeficiency); I felt like I couldn't swallow or breathe; couldn't move; headache; extreme fatigue; joint pain; muscle ache; I must have had swelling in my throat; could not get out of bed; This is a spontaneous report from a contactable consumer (patient). A 71-years-old female patient received bnt162b2 (COMIRNATY, solution for injection, Lot Number: EN6280), via an unspecified route of administration, administered in Arm Left on 18Mar2021 12:45 (age at vaccination 71-Years-old) as dose 2, single for COVID-19 immunisation. Medical history included immunocompromised, little sore in throat, she couldn't swallow and CVID (Common variable immunodeficiency). Concomitant medication included fexofenadine hydrochloride (ALLEGRA) (lot number: 20M610 and expiry date: Apr2023), epinephrine (EPIPEN) (lot number: 1FM339, expiry date: Mar2023) and immunoglobulin human normal (GAMUNEX C) taken for immunodeficiency once weekly dose 1 (batch lot number B3GJE00393, expiry date: 20Jul2023) and dose 2 (batch lot number: B1GGE00133, expiry date: 13Sep2023). she uses 2 separate doses to combine together for her dose, but does not provide the dose amounts. While providing product details stated they have too many zeros. Stated she was to get another infusion in a week. Does not provide any further details. Patient's past drug included Penicillin. It was reported she had about 60,000mg of Penicillin over a 3 day course. She was unable to provide NDC, Lot, or expiry for Penicillin. Caller clarified experience she had at age 30 was prior to any Covid vaccines. No other vaccines given the same day and no problems with vaccines in the past. Patient received historical vaccine bnt162b2 (COMIRNATY, solution for injection, Lot Number: EN6203, expiry date: 01Jun2021), via an unspecified route of administration on 25Feb2021, at 6:45pm, (age at vaccination 71-Years-old) as dose 1, single for COVID-19 immunisation and experienced sore arm. Patient was unable to provide the NDC. On 18Mar2021, around 5pm patient had the sensation of throat was getting sore, but very quickly it went from very sore like couldn't swallow, patient began to feel like she couldn't swallow, the inside of her throat was closed up. She was with her family at the time, so she mentioned to son that she had funny feeling in her throat, but was trying to be brave and be a good example and She didn't make much of it, but if it didn't go away and she felt like she couldn't swallow or breathe she would have him take her to emergency. She knew about all the other symptoms that one could expect but this was not one of them. She was surprised. All that evening, through the night, middle of the night she got the headache and extreme fatigue, joint pain, muscle pain, couldn't move but she expected that so it didn't bother her. she could not get out of bed, but later that night about 5pm it went away. She had 24 hours of the normal reactions, but the throat thing was very scary and didn't want to make a big thing about it then. Her throat was feeling funny but she knew it could have been worse and if so she would not be able to breathe and knows that at that point she would go the hospital. Has an immunocompromised condition and CVID (Common variable immunodeficiency) so she went to see online if the third vaccine came available and she called her Immunologist to sees his recommendation and told him of her experience with the second dose. He responded that, that was a weird reaction regarding her throat and she asked if she should get the third dose since she was able to get through it. Provider recommended her to go ahead and get the third vaccine and to take Allegra. She did some deep breathing, some meditation, by morning it went away, it lifted around 8am. She thought it lifted kind of fast. 1 hour still there, within that hour it was gone. She didn't think about it. It was reported that since she was living outside of her state she went and saw immunologist in. He didn't ask her what symptoms she had and she didn't think to tell him. What he recommended was to go ahead and schedule with local hospital to get the third vaccine. Patient did it without thinking about that, but then thought about it and called him and told him what she just described and he said you already take Allerga. To mitigate symptoms of that, take 2 pills before you go for the vaccine and if you have those symptoms take another 1 or 2. If you get it and it doesn't go away go the emergency. She was almost 72, that's crazy. It's very tough for her to figure out on her own, spent time looking at health agency website last night came across new description about immunocompromised people and if you have a delayed reaction up to 4 hours, swelling anywhere, She must have had swelling in her throat. Now it's beginning to concern her because she went to the health agency website and was researching up to date information due to her being immunocompromised and they actually described what she had and that information was not available back in April and they described that what she was feeling of swelling somewhere that oh my gosh you might not be able to get the vaccine and to contact your doctor to see if there are any alternatives. Which doesn't make any sense because there was no other vaccine available where that symptom may not be present. She thought on her she should have seen this information earlier and she has not called her doctor, but did discuss this with her infusion pharmacy pharmacist who she relies on and it was suggested for her to contact Pfizer whether she should have the third vaccine or not. No further details provided. At the time of this report, the outcome of CVID (Common variable immunodeficiency) was not resolved, I felt like I couldn't swallow or breathe, couldn't move, headache, joint pain, I must have had swelling in my throat was unknown and all other events was resolving.