Skin problems; Adverse events were life alternating, uncomfortable; Adverse events were life alternating, uncomfortable; Swelling all over the body including face, neck,chest, back; Burning sensation all over the body including face, neck, chest, back; Itching all over the body including face, neck,chest, back; Redness all over the body including face, neck,chest, back; Rashes (different kind of rashes); This spontaneous case was reported by a patient and describes the occurrence of SKIN DISORDER (Skin problems), IMPAIRED QUALITY OF LIFE (Adverse events were life alternating, uncomfortable), DISCOMFORT (Adverse events were life alternating, uncomfortable), SWELLING (Swelling all over the body including face, neck,chest, back) and BURNING SENSATION (Burning sensation all over the body including face, neck, chest, back) in a female patient of an unknown age who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 065F21A, 001B21A and 006M20A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     The patient had no known allergies.  The patient had never been tested positive or been diagnosed with COVID-19.  Previously administered products included for Flu: Flu vaccine (Flu vaccine given around 1 month prior to booster dose) in October 2021. Past adverse reactions to the above products included No adverse event with Flu vaccine. Concurrent medical conditions included Hypothyroidism (approximately 35 years ago, no recent change in status such as improvement or worsening). Concomitant products included BRIMONIDINE for Eye disorder prophylaxis, LEVOTHYROXINE for Hypothyroidism, CALCIUM and MULTIVITAMIN [VITAMINS NOS] for an unknown indication.   On 19-Feb-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) .5 milliliter. On 19-Mar-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to .5 milliliter. On 10-Nov-2021, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to .25 milliliter. On 20-Nov-2021, the patient experienced SKIN DISORDER (Skin problems), IMPAIRED QUALITY OF LIFE (Adverse events were life alternating, uncomfortable), DISCOMFORT (Adverse events were life alternating, uncomfortable), SWELLING (Swelling all over the body including face, neck,chest, back), BURNING SENSATION (Burning sensation all over the body including face, neck, chest, back), PRURITUS (Itching all over the body including face, neck,chest, back), ERYTHEMA (Redness all over the body including face, neck,chest, back) and RASH (Rashes (different kind of rashes)). The patient was treated with DIPHENHYDRAMINE HYDROCHLORIDE (BENADRYL [DIPHENHYDRAMINE HYDROCHLORIDE]) at an unspecified dose and frequency; CETIRIZINE HYDROCHLORIDE (ZYRTEC [CETIRIZINE HYDROCHLORIDE]) at an unspecified dose and frequency; HYDROCORTISONE at an unspecified dose and frequency and PREDNISONE at an unspecified dose and frequency. At the time of the report, SKIN DISORDER (Skin problems), IMPAIRED QUALITY OF LIFE (Adverse events were life alternating, uncomfortable), DISCOMFORT (Adverse events were life alternating, uncomfortable), SWELLING (Swelling all over the body including face, neck,chest, back), BURNING SENSATION (Burning sensation all over the body including face, neck, chest, back), PRURITUS (Itching all over the body including face, neck,chest, back), ERYTHEMA (Redness all over the body including face, neck,chest, back) and RASH (Rashes (different kind of rashes)) had not resolved.            The patient was taking Brimonidine for glaucoma prevention.  On 10-Nov-2021, the patient received booster dose of Moderna COVID-19 Vaccine.  The outbreak of the adverse events was not usually on whole body at once, instead they migrated to various parts of body.  The adverse events had been ongoing for the patient for 6 months.  The patient had no problem with rashes prior to vaccination and it just appeared all of a sudden after administration of booster dose.  The treatment medications did not take the adverse events away completely, but helped to relieve some of the adverse events. Once the medications were discontinued, it came back worse than before for the patient.