Tongue, cheek, lips, roof of mouth, also mucous membrane inside of back nostrils were burning, swelling; Tongue, cheek, lips, roof of mouth, also mucous membrane inside of back nostrils were burning, swelling; The initial case was missing the following minimum criteria: No adverse effect. Upon receipt of follow-up information on 29Mar2021, this case now contains all required information to be considered valid.   This is a spontaneous report from a contactable consumer or other non hcp (patient).  An 81-years-old female patient received bnt162b2 (PFIZER-BIONTECH COVID-19 mRNA VACCINE), dose 2 intramuscular, administered in Deltoid Right on 25Feb2021 13:00 (Batch/Lot Number: EN6198) (at the age of 81-years-old) as 2ND DOSE, SINGLE DOSE for covid-19 immunisation. Medical history included restless legs syndrome from an unknown date and unknown if ongoing, multiple allergies from an unknown date and unknown if ongoing, Handicap from an unknown date and unknown if ongoing (7 years), ongoing end stage osteoarthritis (No surgical procedure), allergic to Ampicillin and Penicillin from an unknown date and unknown if ongoing (Patient has had previous allergic reactions 7 years ago and allergic to all other major antibiotics), ongoing chronic pain (No surgical procedure), ongoing fibromyalgia (no surgical procedures), ongoing high blood pressure (no surgical procedures), Lung cancer from Mar2019 and ongoing (MRI's show tumour diminishing. Had radiation in 2019- Stereotactic body radio surgery), allergic to major antibiotics from an unknown date and unknown if ongoing (she had a thick tongue and a puffy roof of her mouth and irritated tongue) and Stereotactic body radio surgery on 2019, chemical sensitivities from an unknown date and unknown if ongoing and PEG reaction to Nutelee from an unknown date and unknown if ongoing. Concomitant medication(s) included oxycodone (MANUFACTURER UNKNOWN, Strength: 10mg) taken for pain from an unspecified start date and ongoing; paracetamol (TYLENOL, Strength: 500mg) taken for pain from an unspecified start date and ongoing; losartan potassium (COZAAR, Strength: 100mg) taken for hypertension from an unspecified start date and ongoing. The patient did not receive any other vaccine prior to bnt162b2. The patient previously took first dose of bnt162b2 (PFIZER-BIONTECH COVID-19 mRNA VACCINE, Lot number: EL8982) via intramuscular administered Left Arm deltoid at 13:00 (at the age of 81-years-old) on 04Feb2021 and experienced Headache, soreness in the arm, random itchiness, increased fatigue, inside of cheeks were puffy, Irritation roof of mouth, tongue was raw, red, and puffy on 04Feb2021 and mucous membranes inside her nose were burning on 05Feb2021, her restless leg was increased, joint and muscle pain. The patient previously took Ampicillin and experienced allergic to Ampicillin and rash (30years ago). The patient experienced Tongue, cheek, lips, roof of mouth, also mucous membrane inside of back nostrils were burning, swelling on 25Feb2021 at 17:00. The patient was advised by physician in phone to take 10mg of Claritin the day before, day of a several days after 2nd dose. It was reported that patient was supposed to have elective surgery, so her doctor wanted to make sure she would be able to take an antibiotic, so her allergist chose Ampicillin. Penicillin NDC/LOT/EXP: Unknown. The patient heard that whatever side effects experienced during first dose they will be more intense after the second dose. Caller says she has not had any other recent vaccinations or started any new medications. She says she has eaten or drank nothing different recently. The patient Claritin 10mg for allergic reaction from 24feb2021 to 28Feb2021 as suggested by the physician. The patient had undergone covid test on 27Oct2020 resulted negative and on 25Jan2021 resulted in negative, and MRI on an unknown date was resulted in tumour diminishing. The patient kept in contact with the allergist through phone. The outcome of the events Tongue, cheek, lips, roof of mouth, also mucous membrane inside of back nostrils were burning, swelling was resolved on 02Mar2021.