Arms itching (treatment for 6 days)/hands itching (treatment for 6 days)/legs itching (treatment for 6 days)/itching is a general feeling in: stomach area-rib line -the back of legs-forearms; Lumps on his chin for 1 day/lumps on his jaw line for 1 day/lumps on his arms for 1 day/lumps on his hands for 1 day/really large lump on his chest for 3 days/At this moment he has a very large lump on his chin; Sore arm, worse than after first dose; Hands swollen (treatment for 6 days)/fingers swollen (treatment for 6 days)/hands swelled worst than ever, under the knuckles; Lips were swollen (treatment for 6 days); Itching inside his throat (treatment for 6 days); Red spots in forearms (treatment for 6 days)/red spots in hands (treatment for 6 days)/red spots in legs (treatment for 6 days)/spots on his bottom or top lips for 1 day; This spontaneous case was reported by a consumer and describes the occurrence of PRURITUS (Arms itching (treatment for 6 days)/hands itching (treatment for 6 days)/legs itching (treatment for 6 days)/itching is a general feeling in: stomach area-rib line -the back of legs-forearms), ERYTHEMA (Red spots in forearms (treatment for 6 days)/red spots in hands (treatment for 6 days)/red spots in legs (treatment for 6 days)/spots on his bottom or top lips for 1 day), LIP SWELLING (Lips were swollen (treatment for 6 days)), THROAT IRRITATION (Itching inside his throat (treatment for 6 days)) and SWELLING (Hands swollen (treatment for 6 days)/fingers swollen (treatment for 6 days)/hands swelled worst than ever, under the knuckles) in a 61-year-old male patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 021B21A and 03(0/6)A21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     Concurrent medical conditions included Penicillin allergy and Allergic reaction to antibiotics (Allergy to amoxicillin). Concomitant products included CHOLINE FENOFIBRATE (FENOFIBRIC ACID [CHOLINE FENOFIBRATE]), METOPROLOL TARTRATE, OMEGA-3-ACID ETHYL ESTER (OMEGA 3 ACID ETHYL ESTERS) and ASCORBIC ACID, CALCIUM, MINERALS NOS, RETINOL, TOCOPHERYL ACETATE, VITAMIN B NOS, VITAMINS NOS, ZINC (CENTRUM SILVER [ASCORBIC ACID;CALCIUM;MINERALS NOS;RETINOL;TOCOPHERYL ACETATE;VITAMIN B NOS;VITAMINS NOS;ZINC]) for an unknown indication.   On 25-Mar-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 23-Apr-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 25-Apr-2021, the patient experienced LIP SWELLING (Lips were swollen (treatment for 6 days)) and THROAT IRRITATION (Itching inside his throat (treatment for 6 days)). On 31-Jul-2021, the patient experienced SWELLING (Hands swollen (treatment for 6 days)/fingers swollen (treatment for 6 days)/hands swelled worst than ever, under the knuckles). On an unknown date, the patient experienced PRURITUS (Arms itching (treatment for 6 days)/hands itching (treatment for 6 days)/legs itching (treatment for 6 days)/itching is a general feeling in: stomach area-rib line -the back of legs-forearms), ERYTHEMA (Red spots in forearms (treatment for 6 days)/red spots in hands (treatment for 6 days)/red spots in legs (treatment for 6 days)/spots on his bottom or top lips for 1 day), SKIN MASS (Lumps on his chin for 1 day/lumps on his jaw line for 1 day/lumps on his arms for 1 day/lumps on his hands for 1 day/really large lump on his chest for 3 days/At this moment he has a very large lump on his chin) and PAIN IN EXTREMITY (Sore arm, worse than after first dose). The patient was treated with HYDROCORTISONE (HIDROCORTIZON [HYDROCORTISONE]) for Swelling, at a dose of 1 dosage form and DIPHENHYDRAMINE HYDROCHLORIDE (BENADRYL ALLERGY [DIPHENHYDRAMINE HYDROCHLORIDE]) for Swelling, at a dose of 1 dosage form. On 03-Aug-2021, SWELLING (Hands swollen (treatment for 6 days)/fingers swollen (treatment for 6 days)/hands swelled worst than ever, under the knuckles) had resolved. At the time of the report, PRURITUS (Arms itching (treatment for 6 days)/hands itching (treatment for 6 days)/legs itching (treatment for 6 days)/itching is a general feeling in: stomach area-rib line -the back of legs-forearms), ERYTHEMA (Red spots in forearms (treatment for 6 days)/red spots in hands (treatment for 6 days)/red spots in legs (treatment for 6 days)/spots on his bottom or top lips for 1 day), LIP SWELLING (Lips were swollen (treatment for 6 days)), THROAT IRRITATION (Itching inside his throat (treatment for 6 days)), SKIN MASS (Lumps on his chin for 1 day/lumps on his jaw line for 1 day/lumps on his arms for 1 day/lumps on his hands for 1 day/really large lump on his chest for 3 days/At this moment he has a very large lump on his chin) and PAIN IN EXTREMITY (Sore arm, worse than after first dose) outcome was unknown.