woke up feeling like garbage; very tired; fever of 101 F; FELT BAD; injection was very painful /arm did continue to be sore; arm got hot; arm started throbbing; her knee start hurting; This case was reported by a consumer via call center representative and described the occurrence of injection site pain in a 72-year-old female patient who received Herpes zoster (Shingrix) for prophylaxis.   Previously administered products included Shingrix with an associated reaction of injection site erythema (1st dose rreceived on 10th Septemnber 2019, refer case US2020016768). Concurrent medical conditions included chest discomfort.   On 14th January 2020, the patient received the 2nd dose of Shingrix (intramuscular). On 14th January 2020, immediately after receiving Shingrix, the patient experienced injection site pain, extremities hot feeling of, throbbing pain and knee pain. On 15th January 2020, the patient experienced feeling unwell, tiredness, fever and feeling bad. The patient was treated with non-drug therapy (Ice Pack (No Medication)). Rechallenge with Shingrix was positive. On an unknown date, the outcome of the injection site pain, extremities hot feeling of, throbbing pain, knee pain, feeling unwell and fever were recovered/resolved and the outcome of the tiredness and feeling bad were unknown.   It was unknown if the reporter considered the injection site pain, extremities hot feeling of, throbbing pain, knee pain, feeling unwell, tiredness, fever and feeling bad to be related to Shingrix.  Additional case details were reported as follows: The injection was very painful. She stayed out running some errands after the injection and got home about 2 hours later. On evening of day of vaccination her arm got hot and started throbbing. Her knee, which had not been particularly painful that day, start hurting much more than it had been. The patient went to bed and iced her knee around 7 PM, and her knee had not hurt enough for her to ice it in weeks. The patient slept that night and the next morning, 15th January 2020, she woke up feeling like garbage. The patient was very tired and she had to call in a sub for the class she was supposed to teach. She took her temperature and had a fever of 101 degree Fahrenheit. The fever was up and down throughout the day and she slept on and off all day. The patient felt bad enough that she did not get up to eat that day. She noticed the day after the vaccine that her knee did not hurt at all. The patient slept through the 2nd night and when she woke up on 16th January 2020 the fever was gone and she no longer felt like garbage. The knee continued to feel fine, and she was able to get up and walk normally for the first time since she had the injury. She went to her orthopedist appointment and nothing was seen on the x-ray they took. They offered to do an MRI, but since her knee was feeling so much better she declined. Her knee has felt fine since and she states it was like Shingrix caused her knee to be fixed. Her arm did continue to be sore until Friday, 17th January 2020. The patient still had a bit of chest congestion, but it was getting better and it did not get any worse after the vaccine. The emergency room visit required. The consent to follow up was granted.