a rough UTI; This is a spontaneous report from a contactable consumer (patient herself). This consumer reporter similar events for three patients. This is First of three report.   A 66-years-old female patient received second dose of BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE, Formulation: Solution for injection, lot number: EN6200; Expiration date: unknown) via an unspecified route of administration, administered in Arm Left on 20Feb2021 (at age of 66-years-old) as DOSE 2, SINGLE for COVID-19 immunization. Medical history included, ongoing sjogren's syndrome; compromised immune system. There were no concomitant medications. Family Medical History Relevant to AE(s); caller stated 2 other family members also had UTIs after the Pfizer Vaccine. Patient had previously received first dose of BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE, Formulation: Solution for injection, lot number: EL9261; Expiration date: unknown) via an unspecified route of administration, administered in Arm Left on 30Jan2021 (at age of 65-years-old) as DOSE 1, SINGLE for COVID-19 immunization. AE(s) following prior vaccinations: Caller stated two years ago, she got a combo of 4 shots, the pneumonia, flu, tetanus and another one all at the same time and she would not say it was an adverse reaction but she was down for several days because of it. Caller stated she will never do that again. NDC, Lot, Expiration: Unknown. Additional Vaccines Administered on same date of the Pfizer suspect was reported as none. Patient did not receive any other vaccines within 4 weeks prior to the COVID vaccine. Caller stated that she received both doses of the Pfizer COVID-19 vaccine, her second one being administered on 20Feb2021 and had recently experienced a rough UTI on 26Jul2021. Caller stated that she was not prone to getting them and was wondering if they were connected to the vaccine. She stated that two of her family members have also had UTIs around the same time, within a month or so. She stated that she just recently went through a UTI, and she was not prone to them and it was a tough one. She stated she has to be on three different types of medications before it knocked it out and it lasted about two weeks. Caller stated that one family member was in the hospital and the reason was originally for a UTI, and her sister-in-law had to go to the emergency room for a UTI. She was looking for any connection to the vaccine and UTIs in the 55 year and older population. Caller stated she was curious about whether or not there was any data on possible UTIs several months after taking the vaccine. Adverse event resulted in physician office visit. Patient had received treatment for AEs. Treatment: Caller stated she had to get a second round of different antibiotics because the first one was not correct. Caller stated the first medication was Amoxicillin and she was given that because didn't want to go in to the doctor. NDC, Lot, Expiration: Unknown Pharmacy Bottle. Caller stated when she got to the urgent care they gave her a combination of Phenazopyridine 200mg and Nitrofurantoin Mono-MCR 100mg after they did the culture, but it did not work. NDC, Lot, Expiration: Unknown. Pharmacy Bottle. Caller stated the expiration is Feb2023. Caller stated she waited until the 6th day of the UTI to go to the Urgent Care. Caller stated then they gave her another one that was a 5 day Steroid that knocked it out. Relevant tests were none. The outcome of event was recovered on 08Aug2021.; Sender's Comments: Linked Report(s) : US-PFIZER INC-202101070859 same reporter/drug/AE with different patient;US-PFIZER INC-202101070858 same reporter/drug/AE with different patient