Depression, a deep depression/feling down for no reason; Feeling tired/super tired; Her arm is still sore; This is a spontaneous report from a contactable consumer. A 58-years-old female patient received bnt162b2 (PFIZER-BIONTECH COVID-19 VACCINE; solution for injection, Batch/Lot Number: ER8729) via an unspecified route of administration, administered in right arm on 14Apr2021 (at the age of 58-years-old) as Dose 2,Single for COVID-19 immunization. The patient's medical history included ongoing overweight gained 30 lbs , ex-tobacco user from 2020 and ongoing. The patient's concomitant medications were not reported. She experienced a deep depression that lasted a day and a half. She got the Pfizer COVID 19 vaccine last Wednesday 14Apr2021 and woke up Thursday 15Apr2021 feeling tired but stated that she expected that. Early in the afternoon on Thursday 15Apr2021 she began feeling down for no reason and couldn't put her finger on it, couldn't figure it out and didn't initially attribute it to the shot and she didn't know what this is. She experienced total detachment, didn't want to do anything, couldn't move around and even had to cancel plans for her birthday. The depression was so devastating she couldn't even shower. Stated that she is not the only person who experienced this side effect from what she understands. Thursday afternoon 15Apr2021 into Thursday night 15Apr2021 and all day Friday 16Apr2021 caller states she felt depressed. On Saturday 17Apr2021, she was finally able to move but it was a stretch because she had to go to grocery store so she had to push herself to go. She could push herself on Saturday 17Apr2021, and the feeling dissipated on Saturday 17Apr2021 and she was more herself on Sunday 18Apr2021. Her arm is still sore and that she had the shot done in the same arm because she figured she didn't want the other arm to hurt if it didn't have to. She used the right arm for both shots and it is very sore. She states that it is an exercise kind of sore, like lifting weights and feels like she has worked out a muscle that she hasn't worked in a while. She didn't read anything about the depression being a side effect and doesn't suffer with depression. Her experience has changed her outlook and respect for people who do have depression and take medications. She realized you can't just push yourself and when her girlfriend was diagnosed with depression caller was so cavalier about it. Her experience has given her some information that she had missed. She thinks it is important because depression isn't listed as a possible side effect. She had the shot on the 14Apr2021. She was perplexed and didn't know what was wrong she was feeling detached, couldn't do anything, couldn't leave the house, couldn't take a shower, couldn't cook, that the experience didn't take her appetite but it was horrible. Super tired physical feeling got better the afternoon of the 15th. She woke up that morning tired and had to call out from her job because she has to be on her game because she is a city bus driver. Even though she went to bed on time she had to call out and it felt like she got hit by a Mack truck. She reported tired feeling dissipated, and she slept up until 11:00 AM. The physical fatigue dissipated as the emotional and mental fatigue consumed her. She finally got up at 11:00 AM on 15Apr2021, she tried to get excited about the next day even though she was off of work. She noticed that her girlfriend called and noticed after the fact that something was going on because caller states that her girlfriend got on her nerves and caller was irritable at that point. She wanted was for her girlfriend to stop singing Happy Birthday to her. She got up about 11:00 AM on 15Apr2021 and was moving around about 12:00 PM. She started really feeling depressed about 1:00 PM that day 15Apr2021. She wanted to get on with her day, she wanted to celebrate being 58 years old for the last time ever but she couldn't. Saturday morning 17Apr2021 the depression started to dissipate and she could really function that afternoon. She had no experience with this feeling, nothing to reference it to. She wasn't 100% until Saturday evening 17Apr2021 / Sunday 18Apr2021 when she was able to get up and move around. She has recovered completely. Her husband didn't say anything but she states she knows she didn't smell so good, she couldn't do anything about it. The outcome for the event her arm is still sore was not recovered/not resolved and recovered/resolved for rest of the events.  No follow-up attempts are needed. No further information is expected.; Sender's Comments: Linked Report(s) : US-PFIZER INC-2021481511 same reporter/drug, similar AE, different patient;US-PFIZER INC-2021481530 same reporter/drug, similar AE, different patient