inflamed joints/ inflammation in joints in both knees/ inflammation in joints in right ankle/ inflammation in joints in her foot/ inflammation in joints in both her thumbs/ inflammation in joints in her jaw; throat closing up; couldn't swallow; neck inflamed; tonsils inflamed; drowsy; rash on her forehead; allergic reaction; This spontaneous case was reported by a consumer and describes the occurrence of ARTHRITIS (inflamed joints/ inflammation in joints in both knees/ inflammation in joints in right ankle/ inflammation in joints in her foot/ inflammation in joints in both her thumbs/ inflammation in joints in her jaw), THROAT TIGHTNESS (throat closing up), DYSPHAGIA (couldn't swallow), SWELLING (neck inflamed) and TONSILLAR INFLAMMATION (tonsils inflamed) in a 30-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch no. 033f21a) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     No Medical History information was reported.    On 15-Nov-2021, the patient received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 21-Nov-2021, the patient experienced ARTHRITIS (inflamed joints/ inflammation in joints in both knees/ inflammation in joints in right ankle/ inflammation in joints in her foot/ inflammation in joints in both her thumbs/ inflammation in joints in her jaw), THROAT TIGHTNESS (throat closing up), DYSPHAGIA (couldn't swallow), SWELLING (neck inflamed), TONSILLAR INFLAMMATION (tonsils inflamed), SOMNOLENCE (drowsy), RASH (rash on her forehead) and HYPERSENSITIVITY (allergic reaction). The patient was treated with METHYLPREDNISOLONE at a dose of 125 mg; DIPHENHYDRAMINE HYDROCHLORIDE (BENADRYL [DIPHENHYDRAMINE HYDROCHLORIDE]) for Allergic reaction, at an unspecified dose and frequency; METHYLPREDNISOLONE (MEDROL DOSEPAK) ongoing since an unknown date at an unspecified dose and frequency; HYDROXYZINE from 27-Nov-2021 to 30-Nov-2021 at an unspecified dose and frequency and IBUPROFEN at an unspecified dose and frequency. At the time of the report, ARTHRITIS (inflamed joints/ inflammation in joints in both knees/ inflammation in joints in right ankle/ inflammation in joints in her foot/ inflammation in joints in both her thumbs/ inflammation in joints in her jaw), THROAT TIGHTNESS (throat closing up), DYSPHAGIA (couldn't swallow), SWELLING (neck inflamed), TONSILLAR INFLAMMATION (tonsils inflamed), SOMNOLENCE (drowsy), RASH (rash on her forehead) and HYPERSENSITIVITY (allergic reaction) outcome was unknown.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On 29-Nov-2021, Chest X-ray: normal (normal) Result: Patient reported Chest X-ray to look for blockages reported negative/normal.. On 29-Nov-2021, Streptococcus test: normal (normal) Result: Patient reported negative/normal strep test. On 29-Nov-2021, X-ray: normal (normal) Result: Patient reported Neck X-ray to look for blockages reported negative/normal..         Concomitant product use was not provided by the reporter. On 27 Nov 2021, Patient  went to medical facility and was given 125 mg shot of methylprednisolone  On 29 Nov 2021, Patient went to the Emergency Room and was tested for strep test, had a neck and chest X-Ray to look for blockages and got normal results Patient was  given a prescription for hydroxyzine and took 2 of them on 27 Nov 2021 and one on 30 Nov 2021, but cannot take during the day because they make her drowsy.   Company comment: This case concerns a 30-year-old, female patient with no medical history, who experienced the unexpected non serious events of arthritis, throat tightness, dysphagia swelling, tonsillar inflammation and somnolence and expected events of rash and hypersensitivity. The events occurred approximately 6 days after the third dose of mRNA-1273. As reported, the patient experienced a rash on her forehead, inflamed joints, and her throat closing up. She explained she had inflammation in her joints in both knees, her right ankle and foot, both of her thumbs and her ja. Patient stated her throat closing up as she couldn't swallow, her neck and tonsils were inflamed. Twelve days after vaccination she went to medical facility and was given a shot of methylprednisolone and two days later she went to the ER and was tested for strep, had a neck and chest xray to look for blockages. All came back negative/normal, as reported. The patient was given Benadryl to stop the allergic reaction and was also given a prescription for hydroxyzine which made her drowsy. She also took ibuprofen for pain. Considering the temporal relation of events and description of symptoms the case was assessed as non serious. Causality for somnolence was assessed as not related as hydroxyzine provides likely etiology. The benefit-risk relationship of mRNA-1273 is not affected by this report.   This case was linked to MOD-2021-403081 (Patient Link).; Sender's Comments: This case concerns a 30-year-old, female patient with no medical history, who experienced the unexpected non serious events of arthritis, throat tightness, dysphagia swelling, tonsillar inflammation and somnolence and expected events of rash and hypersensitivity. The events occurred approximately 6 days after the third dose of mRNA-1273. As reported, the patient experienced a rash on her forehead, inflamed joints, and her throat closing up. She explained she had inflammation in her joints in both knees, her right ankle and foot, both of her thumbs and her ja. Patient stated her throat closing up as she couldn't swallow, her neck and tonsils were inflamed. Twelve days after vaccination she went to medical facility and was given a shot of methylprednisolone and two days later she went to the ER and was tested for strep, had a neck and chest xray to look for blockages. All came back negative/normal, as reported. The patient was given Benadryl to stop the allergic reaction and was also given a prescription for hydroxyzine which made her drowsy. She also took ibuprofen for pain. Considering the temporal relation of events and description of symptoms the case was assessed as non serious. Causality for somnolence was assessed as not related as hydroxyzine provides likely etiology. The benefit-risk relationship of mRNA-1273 is not affected by this report.