feeling of fullness and tenderness in right breast again after 2nd COVID shot; feeling of fullness and tenderness in right breast again after 2nd COVID shot; day after shot extreme fatigue; nipple tenderness; underarm tendernes; This is a spontaneous report from a non- contactable consumer . A 70-year-old female patient (not pregnant) received bnt162b2 (BNT162B2), administered in arm right, administration date 27Feb2021 16:00 (Lot number: EN6202) at the age of 70 years as dose 2, single for covid-19 immunisation. Relevant medical history included: "Meniere's disease" (unspecified if ongoing); "Shellfish allergy" (unspecified if ongoing); "Fish allergy" (unspecified if ongoing); "Allergic to mushroom" (unspecified if ongoing); "Allergic to animals" (unspecified if ongoing); "Allergic to Iodine" (unspecified if ongoing); "Allergic to sulfa antibiotics" (unspecified if ongoing). Concomitant medication(s) included: TRIAMTERENE; HCTZ; ZYRTEC [CETIRIZINE HYDROCHLORIDE]; PEPCID [ALUMINIUM HYDROXIDE; MAGNESIUM TRISILICATE; SODIUM ALGINATE]; TRAVATAN; BETIMOL [TIMOLOL MALEATE]. Vaccination history included: Bnt162b2 (Product: COVID 19, lot number: EL9264, lot: unknown, administration time: 04:15 PM, vaccine location: Right arm, dose number: 1), administration date: 06Feb2021, when the patient was 70 years old, for COVID-19 immunization, reaction(s): "Right breast nipple very itchy, then tender", "Right breast nipple very itchy, then tender", "breast felt a bit full", "breast slightly tender". The following information was reported: BREAST TENDERNESS (non-serious), BREAST DISCOMFORT (non-serious) all with onset 27Feb2021, outcome "not recovered" and all described as "feeling of fullness and tenderness in right breast again after 2nd COVID shot"; FATIGUE (non-serious) with onset 27Feb2021, outcome "unknown", described as "day after shot extreme fatigue"; NIPPLE PAIN (non-serious) with onset 27Feb2021, outcome "not recovered", described as "nipple tenderness"; TENDERNESS (non-serious) with onset 27Feb2021, outcome "not recovered", described as "underarm tendernes". The events "feeling of fullness and tenderness in right breast again after 2nd covid shot", "feeling of fullness and tenderness in right breast again after 2nd covid shot", "day after shot extreme fatigue", "nipple tenderness" and "underarm tendernes" were evaluated at the physician office visit. Therapeutic measures were not taken as a result of breast tenderness, breast discomfort, fatigue, nipple pain, tenderness.  Additional Information: Patient was no pregnant at the time of vaccination. Pfizer does not have permission to contact you about this report. Pfizer does not have permission to contact your/the patient's healthcare provider about this report. Facility where the most recent COVID-19 vaccine was administered was Other. Patient did not receive any other vaccines within 4 weeks prior to the COVID vaccine. List of any other medications the patient received within 2 weeks of vaccination: Triamterene/HCTZ 37.5/25, travoprost (TRAVATAN), timolol maleate (BETIMOL), cetirizine hydrochloride (ZYRTEC), aluminium hydroxide, magnesium trisilicate, sodium alginate (PEPCID). Reported Event: 3-4 days after shot: Right breast nipple very itchy, then tender; breast felt a bit full, slightly tender. Improved, then feeling of fullness and tenderness in right breast again after 2nd COVID shot lot# EN6202 (also in right arm). Adverse event: day after shot extreme fatigue; then fatigue for 2 weeks after shot; right breast discomfort slight full feeling and nipple tenderness; underarm tenderness. Prior to vaccination, patient was not diagnosed with COVID-19. Since the vaccination, patient has not been tested for COVID-19. Allergies to medications, food, or other products: sulfa antibiotics, shellfish, fish, mushrooms, animals, Iodine Vaccine Facility information available. Ethnicity information is available. Race information is available.  No follow-up attempts are possible. No further information is expected.