Acute attack with pleural effusion on 28May; Pericarditis onset early May2022; This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP). The reporter is the patient.  A 59-year-old female patient (not pregnant) received BNT162b2 (BNT162B2), on 09Apr2022 at 15:00 as dose 4 (booster), single (Batch/Lot number: unknown) at the age of 59 years, in left arm for covid-19 immunisation. The patient's relevant medical history included: "R hip replacement", start date: 2015 (unspecified if ongoing), notes: R hip replacement 2015; "Appendectomy", start date: 2009 (unspecified if ongoing), notes: Appendectomy 2009; "Environmental allergies only to dust, pollen, animals" (unspecified if ongoing), notes: Environmental allergies only to dust, pollen, animals; "Environmental allergies only to dust, pollen, animals" (unspecified if ongoing), notes: Environmental allergies only to dust, pollen, animals; "Environmental allergies only to dust, pollen, animals" (unspecified if ongoing), notes: Environmental allergies only to dust, pollen, animals. Concomitant medication(s) included: ACYCLOVIR; ESTRADIOL; PROGESTERONE; PRILOSEC. The patient was not received other vaccine in four weeks since vaccination. Vaccination history included: moderna coviD-19 vaccine (Dose 1, lot number: 003B21A , dose administration time: 14:00 PM, vaccine location: Left arm), administration date: 20Mar2021, when the patient was 58-year-old, for COVID-19 immunization; moderna coviD-19 vaccine (Dose 2, lot number: 001C21A , administration time: 15:00 PM, vaccine location: Left arm), administration date: 17Apr2021, when the patient was 58-year-old, for COVID-19 immunization; BNT162b2 (Dose 3 (BOOSTER), lot number: 320-308D, administration time: 15:00 PM, vaccine location: Left arm), administration date: 26Oct2021, when the patient was 59-year-old, for COVID-19 immunization. The following information was reported: PERICARDITIS (hospitalization, medically significant, life threatening) with onset 04May2022 at 14:00, outcome "recovered with sequelae", described as "Pericarditis onset early May2022"; PLEURAL EFFUSION (hospitalization, life threatening) with onset 28May2022, outcome "recovered with sequelae", described as "Acute attack with pleural effusion on 28May". The patient was hospitalized for pericarditis, pleural effusion (hospitalization duration: 7 day(s)). The events "pericarditis onset early may2022" and "acute attack with pleural effusion on 28may" required physician office visit and emergency room visit. The patient underwent the following laboratory tests and procedures: Nasopharyngeal swab: (06Jun2022) Negative, notes: Nasal Swab. Therapeutic measures were taken as a result of pericarditis, pleural effusion.  Clinical course: The patient stated that pericarditis onset early May2022, acute attack with pleural effusion on 28May. Worsening over next week. Required open heart surgery to remove thick, hardened peel around heart after pericardial window procedure failed to extract fluid. One week in hospital now followed by long recovery period.  The information on the batch/lot number for BNT162b2 has been requested and will be submitted if and when received.