multiple patient that have received Pfizer covid vaccine and some of them are paralyzed from the neck down; Has Pfizer figured out how to create a vaccine that does not cause patients to be at risk from GBS (Guillian-Barre syndrome)?; This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP) from medical information team, Program ID: (Unknown).  A male patient received BNT162b2, BNT162b2 omi ba.4-5 (BNT162B2, BNT162B2 OMI BA.4-5), as dose number unknown (booster), single (Batch/Lot number: unknown) for covid-19 immunisation. The patient's relevant medical history and concomitant medications were not reported. Vaccination history included: Covid-19 vaccine (Primary Immunization series complete; unknown manufacturer), for COVID-19 immunization. The following information was reported: GUILLAIN-BARRE SYNDROME (medically significant) with onset 2021, outcome "recovered", described as "Has Pfizer figured out how to create a vaccine that does not cause patients to be at risk from GBS (Guillian-Barre syndrome)?"; QUADRIPLEGIA (medically significant), outcome "not recovered", described as "multiple patient that have received Pfizer covid vaccine and some of them are paralyzed from the neck down". The information on the batch/lot number for BNT162b2, BNT162b2 omi ba.4-5 has been requested and will be submitted if and when received.  Clinical course: Verbatim Question: Withheld, Occupational Therapy assistant, is treating multiple patient that have received Pfizer COVID vaccine and some of them are paralyzed from the neck down and they cannot recover so she wants to know if there are form of COVID vaccine that will help them. She asked "Has Pfizer figured out how to create a vaccine that does not cause patients to be at risk from GBS (Guillian-Barre syndrome)?" She stated some patients are paralyzed from the neck down and/or waist down. Some patients recover, others do not recover. Has Pfizer Identified a gene to test, that would be identified in specific patients who would be pre disposed to GBS? So that these patients can be allowed to be tested prior to getting vaccine? She doesn't want to any further vaccines, Pfizer or Moderna, until they know they can take a vaccine without the risk of GBS, Pfizer should be testing patients and/or provide information about the risks of GBS. Some patients can afford the "shot to reinsulate the wires, veins, nerves so they can move again" and some patients cannot afford this shot. Name withheld, Occupational Therapy assistant, mentioned she is treating multiple patients that have received the Pfizer COVID-19 vaccine booster and had Guillain-Barre. She asked if we have any kind of a form of the Pfizer COVID-19 vaccine booster that eliminates the chance of getting Guillain-Barre or has replaced those ingredients that would have a different effect, specifically for folks that would be at a higher risk of getting Guillain-Barre. Reaction / Event as Reported by the Primary Source for Translation: Paralyzed due to Guillen Barre due to the Pfizer COVID-19 Vaccine. Dates for paralyzed due to Guillen Barre due to the Pfizer COVID-19 Vaccine: (From: Unknown To: Ongoing). Reporter asked if there was a form of the vaccine to help them recover or testing they can do before the vaccine. Agent stated she is escalating this to the therapeutic team. Reporter clarified she has multiple patients, later stated 4 males, who have been paralyzed due to Guillen Barre from the Pfizer COVID-19 Vaccine. She stated one of them is paralyzed from the neck down and the others from the waist down. The treatment has been different based on income. She reported one can't do anything financially due to income. The other is getting neurological shots that work from the brain down to re-insulate his nerves to get more movement in the body. The shots are done in a series of shots and he has to be able to afford the shots to get better. If the patient doesn't have the money to pay for that, they are sitting in the hospital or at home. She stated they do therapy with them to get them moving as much as possible but they still have a long road to recovery. Reporter stated, so she was trying to find out what is being done to figure out the risk of Guillen Barre from the COVID Vaccine to narrow down the chance of getting Guillen Barre? Is it more likely from the Booster or the First or Second vaccine? What kind of help is being offered to those patients? Reporter has already spoken to Pfizer Medical Information and asked these questions, she is looking for follow up from Pfizer Drug Safety.  Reporter stated she works in multiple facilities so she comes across this regularly. She stated every time she has met a patient that is paralyzed due to Guillen Barre due to the Pfizer COVID-19 Vaccine, and there have been a total of 4, it has always been a man. Reporter stated she has no patient information other than they have been male patients. She does not have dates, NDC, Lot, Expirations. Reporter stated one patient's Guillen Barre was in 2021 and he has recovered completely, but the other 3 never recovered. One is paralyzed from the neck down and the other 2 the waist down. One got his a month ago and now he is paralyzed from the waist down and he is working on the road to recovery. It is almost like a stroke. Reporter stated the most recent patient's seemed to be fine before the contracted Guillen Barre, they may have had arthritis or something but they were working full time and everything. Reporter asked, is there any neurological testing or gene testing? Is there anyway to figure out how to isolate patients to say if they are more susceptible to getting Guillen Barre and then recommend them not getting the vaccine? If a place is going to be giving out COVID vaccines they should be offering a pretest like a TB do a little test and then come back and get results if it confirms or denies if they are at risk for Guillen before getting a Booster or Vaccine. Have they been able to isolate what drug or chemical in the drug increases the chance of getting Guillen Barre? Reporter asking for Follow Up from Pfizer. Sender's Comments: Linked Report(s) : US-PFIZER INC-202300110873 same reporter/drug/event, different patients;