Left arm soreness; Shortness of breath; Nausea; vomiting; Chills; Chest Pain; chest discomfort/Chest Pressure; Fever chills; This spontaneous case was reported by an other health care professional and describes the occurrence of CHEST PAIN (Chest Pain), CHEST DISCOMFORT (chest discomfort/Chest Pressure), PYREXIA (Fever chills), CHILLS (Chills), PAIN IN EXTREMITY (Left arm soreness), DYSPNOEA (Shortness of breath), NAUSEA (Nausea) and VOMITING (vomiting) in a 23-year-old male patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination.     Family history included Heart disease, unspecified (Patient's symptoms did not suggest an ischemic syndrome per cardiology notes). Concurrent medical conditions included Asthma.    On 12-Aug-2021, the patient received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 14-Aug-2021, the patient experienced CHILLS (Chills) (seriousness criterion hospitalization), DYSPNOEA (Shortness of breath) (seriousness criterion hospitalization), NAUSEA (Nausea) (seriousness criterion hospitalization) and VOMITING (vomiting) (seriousness criterion hospitalization). On 15-Aug-2021, the patient experienced PAIN IN EXTREMITY (Left arm soreness) (seriousness criterion hospitalization). In August 2021, the patient experienced CHEST PAIN (Chest Pain) (seriousness criterion hospitalization), CHEST DISCOMFORT (chest discomfort/Chest Pressure) (seriousness criterion hospitalization) and PYREXIA (Fever chills) (seriousness criterion hospitalization). The patient was hospitalized from 15-Aug-2021 to 16-Aug-2021 due to CHEST DISCOMFORT, CHEST PAIN, CHILLS, DYSPNOEA, NAUSEA, PAIN IN EXTREMITY, PYREXIA and VOMITING. The patient was treated with IBUPROFEN for Adverse event, at a dose of 600 mg every eight hours; NITROGLYCERIN for Chest pain, at a dose of UNK unit and KETOROLAC TROMETHAMINE (TORADOL) (intramuscular) for Adverse event, at an unspecified dose and frequency. At the time of the report, CHEST PAIN (Chest Pain), CHEST DISCOMFORT (chest discomfort/Chest Pressure), PYREXIA (Fever chills), CHILLS (Chills), PAIN IN EXTREMITY (Left arm soreness), DYSPNOEA (Shortness of breath), NAUSEA (Nausea) and VOMITING (vomiting) had resolved.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On 14-Aug-2021, C-reactive protein increased: 4.6 (High) CRP 4.6 mg/dL. On 15-Aug-2021, Red blood cell sedimentation rate increased: 621 (High) ESR 621 U/L. On 15-Aug-2021, Troponin: 6743 (Positive) Troponin 6743 ng/L. On 16-Aug-2021, Echocardiogram: normal (normal) Normal left ventricular ejection fraction estimated at 55-65%. Simpson's biplane EF is 59%.. On 16-Aug-2021, Troponin: 3247 (Positive) Troponin 3247 ng/L. On an unknown date, COVID-19: negative (Negative) Negative.     For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown), the reporter did not provide any causality assessments.   Concomitant product was not provided by the reporter  Patient reported that after receiving 2nd dose he experienced fever, chills and sharp chest pain in the mid of the left chest area.  Company Comment: Based on the current available information and temporal association between the use of the product and the start date of the event, a causal relationship cannot be excluded.   This case was linked to MOD-2021-293731 (Patient Link).; Sender's Comments: Based on the current available information and temporal association between the use of the product and the start date of the event, a causal relationship cannot be excluded.