I had two of my patients lose their eyes due to central retinal vein thrombosis after the second dose of the Pfizer BioNTech COVID-19 vaccine.; I had two of my patients lose their eyes due to central retinal vein thrombosis after the second dose of the Pfizer BioNTech COVID-19 vaccine.; This is a spontaneous report from a contactable Physician. This Physician reported different events for 2 patients. This is second of 2 reports. A patient of an unspecified age and gender received bnt162b2 (PFIZER-BIONTECH COVID-19 VACCINE, Solution for injection, Batch/Lot number: not reported), via an unspecified route of administration on an unspecified date as second dose, single for COVID-19 immunization. The patient medical history and concomitant medications were not reported. The patient previously took bnt162b2 (PFIZER-BIONTECH COVID-19 VACCINE), via an unknown route of administration on an unknown date (Batch/Lot number: Not reported) as first dose, single for COVID-19 immunization. Physician reported that on an unspecified date, two of the patients lost their eyes due to central retinal vein thrombosis after the second dose of the Pfizer BioNTech COVID-19 vaccine. Physician wanted to know if there was a way to get a couple of the Pfizer-BioNTech covid-19 vaccine vials. Physician was interested in conducting some preclinical research. Possible AE/PC: This physician, who works in the clinic but was also involved in research, reported that the Pfizer-BioNTech COVID-19 vaccine has a design flaw because Physician mentioned that the transmembrane domain was left in the mRNA and that can lead to cell damage. Physician has seen people lose their eyes, have immune activation, and have had patients die. Physician is going to the (Withheld) and the (Withheld) and everybody to try and block full approval. Physician has already reached out to the FDA and asked to block approval but have not heard anything back yet and mentioned that there was not enough thought and testing done, that it was a mistake to use the whole spike mRNA. Physician also mentioned that if you are immune and get the spike mRNA, it can cause a lot of damage. It gets stuck in the membrane and does not get secreted. It can cause T-cell attack and antibody and compliment attack, and you can wind up with a lot of problems. There is a good chance this is the reason for the myocarditis seen in some young men, the pericarditis we have seen in quite number of patients, and vasculopathy with related clotting. Physician reported that two patients lost their eyes due to central retinal vein thrombosis after the second dose of the Pfizer-BioNTech COVID-19 vaccine. Two patients had retinal vasculitis after getting the Pfizer-BioNTech COVID-19 vaccine. Physician was concerned and mentioned that if we go 6 to 9 months from now and tell people to get a booster of the Pfizer-BioNTech COVID-19 vaccine, we might see horrors. Physician has stopped recommending the Pfizer-BioNTech COVID-19 vaccine to all the patients and family. Physician is very pro vaccine but now thinks that we need to be more vigilant with the Pfizer-BioNTech COVID-19 vaccine. The outcome of the event was unknown.  Information related to batch/Lot no. was requested.; Sender's Comments: As there is limited information in the case provided, the causal association between the events "vision loss", "retinal vein thrombosis" and the suspect drug BNT162B2 cannot be excluded. The case will be reassessed once new information is available. The impact of this report on the benefit/risk profile of the Pfizer product is evaluated as part of Pfizer procedures for safety evaluation, including the review and analysis of aggregate data for adverse events. Any safety concern identified as part of this review, as well as any appropriate action in response, will be promptly notified to regulatory authorities, Ethics Committees, and Investigators, as appropriate.