This spontaneous case was reported by a consumer and describes the occurrence of PALPITATIONS (heart palpitations), PAIN IN EXTREMITY (Left arm soreness), PERIPHERAL SWELLING (Left arm swelling), DYSPNOEA (difficulty breathing) and RASH (red rash on left side) in a 56-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch no. 045B21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below. The patient's past medical history included Stroke and Rotator cuff repair. Concurrent medical conditions included Allergy NOS and Asthma. Concomitant products included SALBUTAMOL SULFATE (VENTOLIN HFA) for an unknown indication. On 20-Apr-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 20-Apr-2021, the patient experienced PALPITATIONS (heart palpitations), PAIN IN EXTREMITY (Left arm soreness), PERIPHERAL SWELLING (Left arm swelling), DYSPNOEA (difficulty breathing), RASH (red rash on left side) and HEADACHE (headache). On 21-Apr-2021, the patient experienced INFLUENZA LIKE ILLNESS (Flu-like" symptoms), WHEEZING (wheezing), ASTHMA (worsening asthma symptoms), DYSPNOEA (worsening difficulty breathing described as "almost choking"), NASOPHARYNGITIS (Cold), FEELING HOT (Really hot), PAIN (Achy), PERIPHERAL SWELLING (Arm swelling), ERYTHEMA (Arm really red whole body red), HYPERHIDROSIS (Sweaty), HYPERHIDROSIS (Hot and cold sweats), NAUSEA (Nausea), FATIGUE (Tiredness) and FATIGUE (Exhausted). On 22-Apr-2021, the patient experienced RASH ERYTHEMATOUS (Red rash on chest), RASH ERYTHEMATOUS (Red rash on shoulder), NECK PAIN (Neck pain) and MUSCLE SPASMS (Cramping in left leg). On 29-Apr-2021, the patient experienced DYSPNOEA (My breathing is still not good), INSOMNIA (I can't sleep great), MUSCLE SPASMS (have very bad cramps in my arm and legs. I could hardly walk on my left leg) and PALPITATIONS (I am scared because of the chest palpitations). At the time of the report, PALPITATIONS (heart palpitations), PAIN IN EXTREMITY (Left arm soreness), PERIPHERAL SWELLING (Left arm swelling), DYSPNOEA (difficulty breathing), RASH (red rash on left side), INFLUENZA LIKE ILLNESS (Flu-like" symptoms), WHEEZING (wheezing), ASTHMA (worsening asthma symptoms), DYSPNOEA (worsening difficulty breathing described as "almost choking"), RASH ERYTHEMATOUS (Red rash on chest), RASH ERYTHEMATOUS (Red rash on shoulder), NECK PAIN (Neck pain), MUSCLE SPASMS (Cramping in left leg), NASOPHARYNGITIS (Cold), FEELING HOT (Really hot), PAIN (Achy), PERIPHERAL SWELLING (Arm swelling), ERYTHEMA (Arm really red whole body red), HYPERHIDROSIS (Sweaty), INSOMNIA (I can't sleep great), HYPERHIDROSIS (Hot and cold sweats), NAUSEA (Nausea), FATIGUE (Tiredness), FATIGUE (Exhausted) and HEADACHE (headache) outcome was unknown and DYSPNOEA (My breathing is still not good), MUSCLE SPASMS (have very bad cramps in my arm and legs. I could hardly walk on my left leg) and PALPITATIONS (I am scared because of the chest palpitations) had not resolved. Not Provided. The action taken with mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) was unknown. Treatment included Advil, Benadryl, Ventolin HFA. Most recent FOLLOW-UP information incorporated above includes: On 28-Apr-2021: Events updated. On 30-Apr-2021: Event Updated.