Two nosebleeds; Heart skipped all day long; This is a spontaneous report from a contactable consumer (patient). An 86-year-old male patient received first dose of BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE; Solution for injection, lot number: EU9231, unknown expiration), via an unspecified route of administration in left arm on 22Jan2021 at a single dose for prevention; apixaban (ELIQUIS), oral from an unspecified date at 2.5 mg twice daily for thromboembolism prophylaxis; and ranolazine (RANEXA), oral from an unspecified date at 500 mg twice daily for an unspecified indication.  Medical history included bypass surgery in 2007, stent placement (5 stents), and 3 blocked arteries, diagnosed several years ago, he guesses he is living on half of them.  There were no concomitant medications. The patient received his first shot of COVID vaccine on 22Jan2021. The patient then experienced two nosebleeds, they did not ask if he had been on a blood thinner, he takes Eliquis, 2.5mg and Ranexa, so his question is a couple days, his heart skips beats anyway, but on the 13th day, it skipped all day long, so he was concerned about the other shot, he was supposed to get it today, he was concerned because he had bypass surgery, had 5 stents, 3 blocked arteries now that they can't do anything about. He was calling about COVID vaccine. He took it 3 weeks ago today and was supposed to get second shot. Concerned as to whether or not he should take it. He was supposed to get the second shot today (12Feb2021), doesn't know, but was really concerned about whether he should take or not. Nosebleeds were the 13th day after the shot (on 04Feb2021). He has recovered completely from nosebleeds. He stated he only bled for a couple seconds. Heart skipped all day long the 13th day after taking the shot (on 04Feb2021), states it is doing fine at this time, comes and goes, may skip one day, next day maybe 3 times and skip, then 4 times and skip, he guesses he has a crazy heart. The patient recovered from the event two nosebleeds on unspecified date, while unknown outcome for the remaining event. The action taken in response to the events for apixaban and ranolazine was unknown.   Additional information was also received by Pfizer from Bristol-Myers Squibb Company (manufacturer control number: US-BRISTOL-MYERS SQUIBB COMPANY-BMS-2021-016064), license party for Apixaban.   This spontaneous case was reported by a consumer and describes the occurrence of EPISTAXIS (Two nosebleeds) and EXTRASYSTOLES (Heart skipped all day long) in 86-year-old male patient who received apixaban (Eliquis) tablet for Thromboembolism prophylaxis. CO-SUSPECT PRODUCTS included ranolazine (Ranexa) tablet for an unknown indication and Covid-19 Vaccine injection for Prevention. The patient's past medical history included Bypass surgery in 2007, Stent placement and Arterial occlusion. On an unknown date, the patient started Eliquis (Oral), 2.5 milligram twice a day and Ranexa (Oral), 500 milligram twice a day. On 22-Jan-2021, the patient started Covid-19 Vaccine (unknown route) by injection once to left shoulder. On 04-Feb-2021, an unknown time after starting Eliquis, the patient experienced EPISTAXIS (Two nosebleeds) and EXTRASYSTOLES (Heart skipped all day long). The action taken with Eliquis(Oral) was unknown. At the time of the report, EPISTAXIS resolved and EXTRASYSTOLES outcome was unknown. For Eliquis(Oral), the reporter did not provide any causality assessments. Nosebleeds were the 13th day after the shot. He took shot on 22Jan2021. Has recovered completely from nosebleeds. States he only bled for a couple seconds. Heart skipped all day long the 13th day after taking the shot, states it is doing fine at this time, comes and goes, may skip one day, next day maybe 3 times and skip, then 4 times and skip, he guesses he has a crazy heart.