high blood pressure; tachycardia; asthma; feeling bad; shortness of breath; This is a spontaneous report from a contactable nurse (patient). A 28-year-old female patient received BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE), the first dose via unspecified route of administration in right arm on 19Aug2021 at 18:00 (lot number: FC3181) as single dose for COVID-19 immunization. The relevant medical history included very low blood pressure from unspecified date, diagnosed allergies from unspecified date, compromised immune status from unspecified date, respiratory illness from unspecified date, genetic/chromosomal abnormalities from unspecified date, endocrine abnormalities (including diabetes) from unspecified date, obesity from unspecified date. Concomitant medications were not reported. The patient experienced high blood pressure on 20Aug2021, tachycardia on 20Aug2021, asthma on an unspecified date in Aug2021, feeling bad on an unspecified date in Aug2021, shortness of breath on an unspecified date in Aug2021. The patient was hospitalized due to high blood pressure, tachycardia and asthma. She was discharged 21Aug2021 or the next days after hospitalization. She was due to receive the second dose. She was asking if it was advisable for her to get the second dose. She was also advised by her cardiologist not to take the second dose. The patient got the first Covid vaccine about 2-3 weeks prior to the report. Was scheduled to get the next one, but the first one put her in the hospital. Was trying to find out if she needed to get the second one. Was hospitalized on the 20Aug2021 for increased blood pressure and being tachycardic. She had to end up seeing her Cardiologist and was put on medicine, Metoprolol 25mg 1/2 tablet by mouth every night, for the tachycardia because her heart rate wouldn't come down. Now since then she had been diagnosed with asthma and she had never had asthma before. Knew if she didn't take the medication, Metoprolol, the heartrate will shoot right back up. Mentioned she had definitely started feeling bad and was getting shortness of breath and they put her on an inhaler every 4 hours for the asthma and it really did help, but she had to use it everyday. Provided the name of the inhaler as Albuterol Sulfate steroid inhaler. She actually used that twice daily and she had been able to catch her breath with using it. No problems with vaccines in past. Stated actually she had very low blood pressure normally and was already seeing a Cardiologist for that, but for her blood pressure to be super high it was from the vaccine. No further details provided. The events high blood pressure, tachycardia required a visit to emergency room and physician office. No other vaccinations within four weeks prior to the first administration date of the suspect vaccine. Therapeutic measures were taken as a result of the events. The outcome of the events was not recovered. Relatedness of drug to reactions/events by the nurse was related.; Sender's Comments: Based on the available information and the strong drug event temporal association, a possible contributory role of suspect product BNT162B2 to development of events cannot be excluded.  The impact of this report on the benefit/risk profile of the Pfizer product is evaluated as part of Pfizer procedures for safety evaluation, including the review and analysis of aggregate data for adverse events. Any safety concern identified as part of this review, as well as any appropriate action in response, will be promptly notified to regulatory authorities, Ethics Committees, and Investigators, as appropriate.