Hives in hairline, around my neck, on my head/welts on the bottom of my feet/Hives on my chest; Red and puffy for about 30 minutes; Really bad heartburn; Skin-writing disease; Super swollen/still get red and swollen; Worst of everything; Left eye swelled shut; Face got really big; Rash all over my body; This spontaneous case was reported by a consumer and describes the occurrence of URTICARIA (Hives in hairline, around my neck, on my head/welts on the bottom of my feet/Hives on my chest), EYE SWELLING (Left eye swelled shut), SWELLING FACE (Face got really big), FEELING ABNORMAL (Worst of everything) and SKIN SWELLING (Red and puffy for about 30 minutes) in a 42-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 012H21B, 036B21A and 028A21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     No Medical History information was reported.   On 28-Mar-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 26-Apr-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 28-Nov-2021, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. In December 2021, the patient experienced EYE SWELLING (Left eye swelled shut), SWELLING FACE (Face got really big), FEELING ABNORMAL (Worst of everything) and RASH (Rash all over my body). On an unknown date, the patient experienced URTICARIA (Hives in hairline, around my neck, on my head/welts on the bottom of my feet/Hives on my chest), SKIN SWELLING (Red and puffy for about 30 minutes), DYSPEPSIA (Really bad heartburn) and MECHANICAL URTICARIA (Skin-writing disease). The patient was treated with PREDNISONE on 10-Dec-2021 for Adverse event, at a dose of prescribed by the urgent care for 6 days; DIPHENHYDRAMINE HYDROCHLORIDE (BENADRYL [DIPHENHYDRAMINE HYDROCHLORIDE]) for Adverse event, at an unspecified dose and frequency; HYDROCORTISONE for Adverse event and Itching, at an unspecified dose and frequency; LORATADINE (CLARITINE) for Adverse event, at an unspecified dose and frequency and FAMOTIDINE (PEPCID [FAMOTIDINE]) for Adverse event, at an unspecified dose and frequency. At the time of the report, URTICARIA (Hives in hairline, around my neck, on my head/welts on the bottom of my feet/Hives on my chest), EYE SWELLING (Left eye swelled shut), SWELLING FACE (Face got really big), FEELING ABNORMAL (Worst of everything), SKIN SWELLING (Red and puffy for about 30 minutes), DYSPEPSIA (Really bad heartburn) and RASH (Rash all over my body) outcome was unknown and MECHANICAL URTICARIA (Skin-writing disease) was resolving.            No concomitant medications was provided by the reporter. The patient reported starting prednisone prescribed by the urgent care on 10-Dec-2021 for 6 days. Patient took Benadryl at night to help her sleep. Patient used hydrocortisone cream when something would flare up. It kind of relieved the itching. Patient also tried Claritin and Pepcid, but they were not doing much. Patient wanted to try Zyrtec or Allegra, but Patient had not yet.