Information has been received from the patient and the mother of the patient via an online article dated 14-MAR-2019. The patient was an approximately 12 year old female. The patient's medical history was noted as rarely sick. Concurrent conditions and concomitant medication use were not provided. In approximately 2014, the patient was administered GARDASIL (lot#, indication for use, and route of administration were not provided). At the time the article was written (2019) the patient was 17 years old. For the past five years (2014), the teen has had good days and bad days. Her joints swell. She gets unexplained rashes. Hives come and go.  Her body is chronically tired and achy and sometimes she can't swallow.  "Sometimes, no matter what I do, I have shooting pain in my arms and legs," That's when she uses a cane, or a wheelchair to get around. She can't remember things. "It's like I have the memory of a dementia patient." In the height of the symptoms, the patient spent a month in bed because she simply didn't have the strength to get up. She has developed a sensitivity to mold, which increases her symptoms and prevents her from going many places, including school. "I can't go to school," said the high school junior. "I do online schooling." She had to quit all her activities, including band, chorus, swim team, and Crew.  "I sit in bed and do school work, then I may play video games or watch Netflix. If I feel up to it, I water my plants," she said as she sat crossed-leg on a sofa in her living room. "I'm pretty much trapped here." Until about five years ago, the patient was healthy. "She was rarely sick," recalled her mother. Suddenly, however, her health began to decline. "When it started, it looked like a common cold." The patient had headaches, was tired, achy and had coughing episodes. "I had full body pain, I was nauseous, dizzy." She slept most of the time. The patient went to the doctor who told her it was a respiratory infection and prescribed antibiotics. But things didn't improve, and they returned to the pediatrician, who sent them to a specialist. The doctor told the patient and her mother that "Everything in her body is inflamed." She was tested for Lyme disease (results not provided).  At one point, they assured her she had Juvenile Rheumatoid Arthritis. Then, it was fibromyalgia and patellofemoral pain syndrome. But none of the treatments touched her pain. "We've had a lot of different diagnoses," the patient's mother said. They finally sent her to a  Hospital, where she participated in a program that promised her relief. According to the patient's mother "The program made her worse, not better." "They wanted to give a 14-year-old oxycodone and send her home." As a mother, she was worried. "No one has pain for no reason at all."  The patient is the oldest of her three children and, like any mother, she wanted to help her child.  She spent hours online looking for clues. She turned to social media looking for another doctor who might be able to help. The patient's mother recalled that right after her daughter got the "HPV and flu vaccines" that when all of her symptoms started.  If feeling miserable most of the time and not being able to do things other teenagers do is disheartening, it's nothing compared to the other side effects of her illness. The patient stated; "A lot of my friends didn't know how to deal with it and some ended up picking on me." "It made me feel terrible. I was in so much pain and no one believed me." "She lost all but one friend," her mother said. "I understand. It's like an invisible illness and unless people have something you can see, they think you're lying." The patient said she often smiles beyond the pain. "It's not like I'm gonna act sick and miserable 24/7. No one would want to be around me." Her illness has taken a toll on the family as well.  The mother stays home to care for her daughter.  "We try to be parents to all three of our children."  "We've tried to spread it around, but it's hard." The patient said her relationship with her siblings has changed, too.  "I'm not as close as I used to be with my brother and sister," she stated as she wiped tears from her cheeks. "I just don't feel good. They've grown up and I've missed things."  The family believes they have finally gotten an accurate diagnosis for what's going on with their daughter.  They found a specialist who stepped in to help. "He believes she has chronic inflammatory response syndrome caused by the HPV and flu vaccines. "The doctor said with those two together, it was just too much."  "What I've learned is it depends on what's in your genetic makeup," the mother explained. "There's something in our genetics that affects them." The doctor has prescribed a program of drugs and supplements to try to get the patient's system back to normal. "They said it's completely curable, but it's going to take a while." There is a new stem cell treatment out there that promises to speed healing, however insurance doesn't cover it. The first round, which she took last month, was $6,300 and then $1,600 each round after that and that's not including doctor visits and supplemental medications. But the expense is worth it so far. "We're seeing great things already," the patient's mother said of the new treatment.  "This is not an easy ask for us," stated the father of the patient.  "Last year, we spent $38,000 on medical stuff. This year, we're already into $10,000. We're not at the point where we're begging for food. We just need help to provide her the care she needs. The medical bills are going to keep coming until she's better. When it's your daughter, you'll do anything. Any donation is welcomed and appreciated."  Meanwhile, the patient is just hopeful the treatment works. "I'm hoping to be able to return to school to graduate with my class. I want to go to classes and do all the in-class stuff. I want to be able to go to college." The patients mother stated "We're just living day-by-day. We're just hoping to get her better, so she can live a normal life and go to college." Chronic inflammatory response syndrome caused by the HPV and flu vaccines was considered disabling as the patient had to stay in bed for a month, was not able to go to school and had to use a wheelchair or walker. Upon internal review chronic inflammatory response syndrome caused by the HPV and flu vaccines was considered medically significant. Additional information is not expected. This is one of two reports from the same reporter.  See MARRS#1903USA008562 for additional adverse event information regarding a different patient.; Sender's Comments: US-009507513-1903USA008562: