couldn't sink, couldn't speak, lost consciousness; stroke; have thrombosis; Susac cerebral vasculitis; lost 25 pounds; auto immune disease; had a follicle/follicle that was bigger than weight ovary; not eating, did not eating for about a week; more inflammation; Having some cognitive problems; have osmotic pressure and in tears; couldn't sink, couldn't speak, lost consciousness; sick as a dog; feet swell; cough; excruciating pain/could not lay on any part of body for more than a couple minutes, could lay on spine, could lay on side, could lay on stomach; veins like protruding in my forehead; post-menopausal bleeding; This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP). The reporter is the patient.  A 48-year-old female patient received BNT162b2 (BNT162B2), as dose number unknown (booster), single (Lot number: FH8028), as dose 2, single (Lot number: EP7534) and in 2021 as dose 1, single (Lot number: EN6203) for covid-19 immunisation; sulfamethoxazole, trimethoprim (BACTRIM), (Batch/Lot number: unknown); gabapentin (GABAPENTIN), (Batch/Lot number: unknown); topiramate (TROKENDI), first regimen (Batch/Lot number: unknown) at 25 mg and second regimen (Batch/Lot number: unknown) at 100 mg. The patient's relevant medical history included: "JAK 2 gene" (unspecified if ongoing); "chronically sick" (unspecified if ongoing); "migraine" (unspecified if ongoing); "inflammation" (ongoing). There were no concomitant medications. The following information was reported: POSTMENOPAUSAL HAEMORRHAGE (medically significant) with onset 2021, outcome "unknown", described as "post-menopausal bleeding"; LOSS OF CONSCIOUSNESS (medically significant), LACK OF SPONTANEOUS SPEECH (non-serious), outcome "unknown" and all described as "couldn't sink, couldn't speak, lost consciousness"; CEREBROVASCULAR ACCIDENT (medically significant), outcome "unknown", described as "stroke"; THROMBOSIS (medically significant), outcome "unknown", described as "have thrombosis"; CENTRAL NERVOUS SYSTEM VASCULITIS (medically significant), outcome "unknown", described as "Susac cerebral vasculitis"; WEIGHT DECREASED (medically significant), outcome "unknown", described as "lost 25 pounds"; IMMUNE SYSTEM DISORDER (non-serious), outcome "unknown", described as "auto immune disease"; OVARIAN DISORDER (non-serious), outcome "unknown", described as "had a follicle/follicle that was bigger than weight ovary"; EATING DISORDER (non-serious), outcome "unknown", described as "not eating, did not eating for about a week"; INFLAMMATION (non-serious), outcome "unknown", described as "more inflammation"; COGNITIVE DISORDER (non-serious), outcome "unknown", described as "Having some cognitive problems"; BLOOD OSMOLARITY ABNORMAL (non-serious), outcome "unknown", described as "have osmotic pressure and in tears"; ILLNESS (non-serious), outcome "unknown", described as "sick as a dog"; PERIPHERAL SWELLING (non-serious), outcome "unknown", described as "feet swell"; COUGH (non-serious), outcome "unknown"; PAIN (non-serious), outcome "unknown", described as "excruciating pain/could not lay on any part of body for more than a couple minutes, could lay on spine, could lay on side, could lay on stomach"; VEIN DISORDER (non-serious), outcome "unknown", described as "veins like protruding in my forehead". The events "susac cerebral vasculitis", "have osmotic pressure and in tears", "excruciating pain/could not lay on any part of body for more than a couple minutes, could lay on spine, could lay on side, could lay on stomach" and "veins like protruding in my forehead" required emergency room visit. The action taken for sulfamethoxazole, trimethoprim, gabapentin and topiramate was unknown.  Clinical course: The patient had been really sick for the past two years. The patient was sick prior she had some chronic stuff going on, she was not like with headache something. The patient had some chronic shit going on before she had this vaccine (COVID-19 vaccine), she was chronically sick for about 12 years migraine and things of that nature and then once COVID hit the air like at the end of 2019. She did not get COVID first day. The patient reactivated with, like a lot of people did after COVID and she had problems with medicines which it looks like she had been having vaccine advisory since she was the small child. She had been taken out of school antibiotic reactions. After 2019, at the end of 2019 that was when she started really having hard time and rashes all kind of sickness after medicine and vaccines and stuff so then in 2021. Antibiotics, Bactrim. Right now, the patient could not take any medicine. Every medicine she took now was giving she an inflammatory, was making she inflammation in her body worse, pressure in her head. Bactrim but there was been a lot of medicines (unspecified medication) she took an about a dozen medicines in, since the COVID vaccine. She know all making her sick. They were all giving her an inflammatory. Patient clarified the name of medication as Pfizer COVID-19 vaccine and did not get to what happened after the COVID vaccine. Currently, the patient had auto immune disease and some thing said weren't diagnosed back then that she had been dealing with her whole life. The patient got her first COVID vaccine in Mar2021 or Feb2021 and 7 days later she had post-menopausal bleeding to which she had a follicle. It was found that a follicle that was bigger than her weight ovary so then that was within the week after. So within from Mar to Jul, the patient lost 25 pounds. All of her chronic stuff that she was dealing with regarding inflammation through the prior 12 years got considered reversed like just unreal, pressure in her head the inflammation was, all of chronic stuff got hundred percent worse to like she said I lost 25 pounds. The patient was missed a lot of work during that time and she was giving different medicines and stuff like she said that were making, causing more inflammation like nobody believed her at that time. The patient thought people were kind looking at you like she was crazy so then in after she was out of work for three weeks and she went tried to go back in the work for one day and she was not eating, did not eating for about a week and the next day she started grown and up. The patient could not lay on any part of body for more than a couple minutes, could lay on her spine, could lay on side, could lay on her stomach. The patient around because she could not put pressure on any part of her body for more than a couple of minutes so that been an excruciating pain, she could not keep shoes down, could not keep water down so she went to the emergency room this was 22Jul2021. The year before there was no like 04Jul (like the biggest holiday ever because of the COVID ), so she round up going to the emergency room during the biggest holiday ever which not been able to put any pressure on her body and it was the shit show. The hospitals were a mess. She had veins, veins like protruding in her forehead. She was there were for thirty hours had no neurological nothing, then sent her home, the next day so two days later she got to the point where her head, she couldn't sink, couldn't speak, lost consciousness. And when she wake up. She can't she just mentally she like she said she have stroke of some throat she went walking up onto a highway. The patient had a Pfizer Vaccine, she started getting sick two weeks after got her first vaccine. She started having side effects. The patient didn't get any point of she stroke. She not sure why she was cutting off before she got to the point while she had stroke. The patient had firm doses, she just got a bunch of genetic tests. The patient had been diagnosed with the JAK 2 gene and the C3 gene(C3 compliment), which was the compliment and she am saying now that what causing the warm COVID, that was what she had now since this vaccine. There were all the case studies now and she have been genetic testing now that showed she had the since that were causing the stroke was well documented as this point. She had a history of  JAK 2 gene, looks like. Now she was having an issue with the thrombosis. problems with her blood. She never had this. Currently she had gene that she can developed it but she didn't develop any of the 'seen' through the vaccine. She had a stroke and was having some cognitive problems. A lot of vaccine, there is not just vaccine. It was every medicine. She take any medicine right now. they got it giving her the inflammatory response. She was given Gabapentin. She had been given about 3 dozen medications (unspecified medication) and all making her feet swell, they all causing inflammation, every single one of them. She was give about 6 different medications (unspecified medications) and she couldn't take them all but she did not have them all in front of them. She was going to give you a doctor and a different medication. It was Trokendi, it was a headache medicine, a migraine medicine and that made her worse because of the pressure in her head. It was a migraine medicine. So when she took it made her migraine worst instead of better. She could not take any medication because of the Pfizer Vaccine, whether they were Pfizer medication or not she could not take any medication right now. All the medication that they gave her like anxiety medicine and shit like every kind of medication. The patient had literally have been out of work for 2 years and she was sick as a dog and she was taking not one medication right now. It's all making her sick. She had been using Gabapentin for years. The patient was not sure how long she took Trokendi before she stop it because all these medicines like she take them and they usually (incomplete sentence). What they were doing with the information, they were causing bronchospasm, where she could not breath like she had been in the urgent care with bronchospasm because the inflammation was still bad so she took these medications where she could not breathe. Treatment for the events: Inhaler, Albuterol. Dose of Albuterol: Because it gives her inflammation and she had been getting cough. It said 90 mcg/Actuation. She had been in the emergency room twice this month because of the new medicines (Unspecified Medications) that they tried, given her heart palpitations and chest pains and breathing problems, that was this month, she could breathe, actually in the past 6 weeks she had been to the ER 3 times because she started new medications that made her inflammation worse. She got a booster (COVID-19 Booster vaccine) which was her fault, she should have never done that after she got that first 2 but like she said she thought she was going back to work and it was going to be required FH8028 (LOT#). She had a Flu Shot (unspecified Flu Shot). she had reactions to the Flu shot as well. Treatment (allergic reaction from flu shot): inflammation, every vaccine and medicine it caused the more inflammation in her body, her face and her nose. She could not keep her glasses on. At night she had 'osmotic pressure' and was in tears. She was telling any medicine or vaccine (unspecified vaccine) other than a steroid for inflammation, every other medicine was causing inflammation. Feb2021 the antibiotic may have been before now, it may have been before her shot, Bactrim. Well Right now she did a genetic test just do the partial genetic test before she had a full genetic test and it was showing that she have the JAK2 gene which was blood clotting thrombosis and they thought she had Susac cerebral vasculitis when she had the stroke now it looked like it might have been Cerebral venous sinus thrombosis in her head. She just got a gene test and just got know she had thrombosis so she was just trying to figure out why Pfizer's vaccine did this to her. Looked at the thrombosis because of the gene test they have not been able to figure out what was causing and she had so many things wrong with her right now they have her gene test.