Chronic plaque psoriasis flare-up; stress; Pain, discomfort and fatigue caused by second and booster dose of Moderna COVID vaccine; Pain, discomfort and fatigue caused by second and booster dose of Moderna COVID vaccine; Pain, discomfort and fatigue caused by second and booster dose of Moderna COVID vaccine; This spontaneous case was reported by a consumer and describes the occurrence of PSORIASIS (Chronic plaque psoriasis flare-up), STRESS (stress), PAIN (Pain, discomfort and fatigue caused by second and booster dose of Moderna COVID vaccine), DISCOMFORT (Pain, discomfort and fatigue caused by second and booster dose of Moderna COVID vaccine) and FATIGUE (Pain, discomfort and fatigue caused by second and booster dose of Moderna COVID vaccine) in a 49-year-old male patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination.    Co-suspect product included non-company product RISANKIZUMAB (SKYRIZI [RISANKIZUMAB]) for Plaque psoriasis.    Concurrent medical conditions included Plaque psoriasis (Moderate to severe chronic plaque psoriasis).   On 30-Mar-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 28-Apr-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. On 08-Dec-2021, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. On an unknown date, the patient started RISANKIZUMAB (SKYRIZI [RISANKIZUMAB]) (Subcutaneous) at an unspecified dose. In 2021, the patient experienced PAIN (Pain, discomfort and fatigue caused by second and booster dose of Moderna COVID vaccine), DISCOMFORT (Pain, discomfort and fatigue caused by second and booster dose of Moderna COVID vaccine) and FATIGUE (Pain, discomfort and fatigue caused by second and booster dose of Moderna COVID vaccine). On an unknown date, the patient experienced PSORIASIS (Chronic plaque psoriasis flare-up) and STRESS (stress). At the time of the report, PSORIASIS (Chronic plaque psoriasis flare-up) and STRESS (stress) had not resolved and PAIN (Pain, discomfort and fatigue caused by second and booster dose of Moderna COVID vaccine), DISCOMFORT (Pain, discomfort and fatigue caused by second and booster dose of Moderna COVID vaccine) and FATIGUE (Pain, discomfort and fatigue caused by second and booster dose of Moderna COVID vaccine) outcome was unknown.            No concomitant medication was reported.  On 08-Dec-2021, the patient received the booster dose of Moderna COVID-19 vaccine. The patient had plaques on legs, stomach and back of scalp. His left ankle affected the most of legs. His  stress and cold weather caused chronic plaque psoriasis flare ups. He had scaling on scalp close to left ear  and left ankle. It was unknown if the patient was enrolled in a COVID-19 Vaccine Trial.  No treatment information was reported.  The reporter causality for event STRESS (stress) with co-suspect Skyrizi was not provided. The reporter causality for event PAIN (Pain, discomfort and fatigue caused by second and booster dose of Moderna COVID vaccine), DISCOMFORT (Pain, discomfort and fatigue caused by second and booster dose of Moderna COVID vaccine) and FATIGUE (Pain, discomfort and fatigue caused by second and booster dose of Moderna COVID vaccine)  with co-suspect Skyrizi was no reasonable possibility. The reporter causality for event PSORIASIS (chronic plaque psoriasis flare up) with co-suspect Skyrizi was a reasonable possibility.  This case was identified as part of a retrospective clean-up activity where certain emails received in the Moderna mailbox were missed to be booked-in.   This case was linked to MOD-2022-619152, MOD-2022-630551 (Patient Link).   Most recent FOLLOW-UP information incorporated above includes: On 20-Apr-2022: Follow-up includes no new information.