difficult to sleep; On the night of 04May2021, the arm that the caller got the injection in was totally numb; The caller's calf was tingling by her ankles but it seemed like a secondary issue; lower calf got super swollen and hard/it was the hardness in the calf that was the concern; The caller had kind of the same sore arm as the first dose and was a little tired the next day; The caller had kind of the same sore arm as the first dose and was a little tired the next day; This is a spontaneous report received from contactable reporter(s) (Consumer or other non-HCP). The reporter is the patient.  A 46-year-old female patient received bnt162b2 (BNT162B2), administered in arm left, administration date 29Apr2021 (Lot number: EP7534) at the age of 46 years as dose 2, single for covid-19 immunisation. The patient's relevant medical history was not reported. Concomitant medication(s) included: LEVOTHYROXINE; VALTREX. Vaccination history included: Covid-19 vaccine (Dose1, Unknown manufacturer, lot ER8730, Location: upper left arm), administration date: 08Apr2021, for covid-19 immunization, reaction(s): "sore arm".  The following information was reported: PAIN IN EXTREMITY (non-serious) with onset 29Apr2021, outcome "unknown", FATIGUE (non-serious) with onset 30Apr2021, outcome "recovering" and all described as "The caller had kind of the same sore arm as the first dose and was a little tired the next day"; PERIPHERAL SWELLING (non-serious) with onset 03May2021, outcome "recovering", described as "lower calf got super swollen and hard/it was the hardness in the calf that was the concern"; HYPOAESTHESIA (non-serious) with onset 04May2021, outcome "recovering", described as "On the night of 04May2021, the arm that the caller got the injection in was totally numb"; PARAESTHESIA (non-serious) with onset 04May2021, outcome "recovering", described as "The caller's calf was tingling by her ankles but it seemed like a secondary issue"; INSOMNIA (non-serious), outcome "unknown", described as "difficult to sleep". Relevant laboratory tests and procedures are available in the appropriate section.  Additional Information: The patient taking Pfizer covid vaccine to prevent getting the virus. She had taken Levothyroxine and Valtrex as concomitant products for outbreaks. She did not had history. The caller noticed on 29Apr2021 that she had something going on her leg, over the next days the caller right lower calf got super swollen and hard. The caller unsure if its from the vaccine. On the night of 04May2021, the arm that the caller got the injection in was totally numb. When the caller went to sleep, she woke up and her hand was completely numb with pins and needles and she had to shake it out. This never happens to the caller. It was difficult to sleep because of this and the caller was worried. When the caller turned over on the other side, this happened to the next hand. On 05May2021 the caller went to the emergency room and they did every test you could think of. The medical team was concerned about leg because of the swelling. The caller had a CT scan because they were worried about a stroke or something, which would be unlikely because she was so young. All of the tests came back fine. Last night was the first night that the caller did not have the tingling in her arms when she slept. When the caller arms and hands fell asleep she was not laying on them to prompt that to happen. On 30Apr2021, tiredness improved. Right lower calf got super swollen and had, improved. The caller later clarifies that the right calf swelling started late 03May2021. The caller went to her primary care provider on 04May2021. The caller calf was tingling by her ankles but it seemed like a secondary issue, it was the hardness in the calf that was the concern. The caller visited the emergency room on 05May2021 but was not admitted. Numbness and tingling in arms and hands improved. This happened in both of her arms. It was really bad in her left arm and it happened for 2 nights and then when she was sleeping her hand was completely asleep with the pins and needles and she had to shake it out. The numbing sensation was mild in the day and when her arms were inactive in the nights the numbness and tingling happened. The first night was the worst, the caller hands were completely numbed out and tingling. Last night, 06May2021, was the first time it did not happen.   No follow-up attempts are possible. No further information is expected.