booster; Orthostatic Hypotension, I collapsed upon standing; Orthostatic Hypotension; sinus and throat irritation and sensation of closing; sinus and throat irritation and sensation of closing; sinus and throat irritation and sensation of closing; sinus and throat irritation and sensation of closing; my diastolic blood pressure kept dropping into the low 50's, and then normalizing, then dropping again; dizziness; racing then slow heartbeat; racing then slow heartbeat; extreme fatigue; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP). The reporter is the patient.  A 39 year-old female patient (not pregnant) received bnt162b2 (BNT162B2), administered in arm right, administration date 24Nov2021 (Lot number: FF2590) at the age of 39 years as dose 3 (booster), single for covid-19 immunisation. Relevant medical history included: "Celiac disease" (unspecified if ongoing); "Chronic fatigue" (unspecified if ongoing), notes: Chronic fatigue(unspecified); "Autism" (unspecified if ongoing); "Bipolar disorder" (unspecified if ongoing); "Migraines" (unspecified if ongoing); "Low iron" (unspecified if ongoing); "Thyroid nodule" (unspecified if ongoing); "uterine fibroid" (unspecified if ongoing); "2 brain injuries" (unspecified if ongoing). Concomitant medication(s) included: LAMOTRIGINE; TOPAMAX; CETIRIZINE; FAMOTIDINE; LYSI COD LIVER OIL. Past drug history included: Prochlorperazine, reaction(s): "known allergy: Prochlorperazine"; Known allergy: doxycycline, reaction(s): "allergy"; Known allergy: iodinated contrast media, reaction(s): "allergy"; Known allergy: gadolinium, reaction(s): "allergy"; Known allergy: escitalopram, reaction(s): "allergy"; Known allergy: shiitakes, reaction(s): "allergy". Vaccination history included: Bnt162b2 (Dose Number: 2, lot number=EW0173, vaccine location=Right arm), administration date: 04May2021, when the patient was 39 years old, for covid-19 immunization; Bnt162b2 (Dose Number: 1, lot number=ER2613, vaccine location=Left arm), administration date: 23Mar2021, when the patient was 38 years old, for covid-19 immunization. The following information was reported: IMMUNISATION (Medically significant) with onset 24Nov2021 13:45, outcome "unknown", described as "booster"; SYNCOPE (medically significant) with onset 24Nov2021 13:45, outcome "recovering", described as "Orthostatic Hypotension, I collapsed upon standing"; ORTHOSTATIC HYPOTENSION (medically significant) with onset 24Nov2021 13:45, outcome "recovering", described as "Orthostatic Hypotension"; THROAT IRRITATION (non-serious), SINUS DISORDER (non-serious), SINUS PAIN (non-serious), THROAT TIGHTNESS (non-serious) all with onset 24Nov2021 13:45, outcome "recovering" and all described as "sinus and throat irritation and sensation of closing"; BLOOD PRESSURE DIASTOLIC DECREASED (non-serious) with onset 24Nov2021 13:45, outcome "recovering", described as "my diastolic blood pressure kept dropping into the low 50's, and then normalizing, then dropping again"; DIZZINESS (non-serious) with onset 24Nov2021 13:45, outcome "recovering", described as "dizziness"; HEART RATE IRREGULAR (non-serious), HEART RATE INCREASED (non-serious) all with onset 24Nov2021 13:45, outcome "recovering" and all described as "racing then slow heartbeat"; FATIGUE (non-serious) with onset 24Nov2021 13:45, outcome "recovering", described as "extreme fatigue". The events "orthostatic hypotension, i collapsed upon standing", "orthostatic hypotension", "sinus and throat irritation and sensation of closing", "sinus and throat irritation and sensation of closing", "sinus and throat irritation and sensation of closing", "sinus and throat irritation and sensation of closing", "my diastolic blood pressure kept dropping into the low 50's, and then normalizing, then dropping again", "dizziness", "racing then slow heartbeat", "racing then slow heartbeat" and "extreme fatigue" were evaluated at the physician office visit. It was unknown if therapeutic measures were taken as a result of immunisation, syncope, orthostatic hypotension, throat irritation, sinus disorder, sinus pain, throat tightness, blood pressure decreased, dizziness, heart rate irregular, heart rate increased, fatigue. Vaccination facility: Doctors office/urgent care. Patient had not received any other vaccine in four weeks. Clinical Course: Orthostatic Hypotension, she collapsed upon standing, her diastolic blood pressure kept dropping into the low 50's, and then normalizing, then dropping again. Also, extreme fatigue, dizziness, racing then slow heartbeat, sinus and throat irritation and sensation of closing, like a mild sulfite allergy. Patient not had covid-19 prior to vaccination. patient was not tested for covid-19 post vaccination.  No follow-up attempts are possible. No further information is expected.