Numbness in corner of lips; Neck ache; Body started going numb/ felt in finger arm and shoulder/ numbness in toes and foot pad/ numbness is just in the right; Head was aching; Fever/Horrible fever of 105 degree Fahrenheit; Horrible shaking; Body was feeling miserable; This spontaneous case was reported by a patient and describes the occurrence of HYPOAESTHESIA ORAL (Numbness in corner of lips), TREMOR (Horrible shaking), FEELING ABNORMAL (Body was feeling miserable), NECK PAIN (Neck ache) and HYPOAESTHESIA (Body started going numb/ felt in finger arm and shoulder/ numbness in toes and foot pad/ numbness is just in the right) in a 74-year-old female patient who received mRNA-1273 BIVALENT .222 (MODERNA COVID-19 VACCINE, BIVALENT (ORIGINAL AND OMICRON BA.4/BA.5)) (batch no. D52D22A) for COVID-19 prophylaxis. The occurrence of additional non-serious events is detailed below.     It was reported that patient has never been diagnosed/tested positive for COVID-19.  Previously administered products included for Product used for unknown indication: Pfizer (Dose 1) on 22-Jan-2021, Pfizer (Dose 2) on 12-Feb-2021, Pfizer (1st Booster Dose) on 23-Oct-2021 and Pfizer (2nd Booster Dose) on 07-Apr-2022. Past adverse reactions to the above products included No adverse event with Pfizer, Pfizer, Pfizer and Pfizer. Concurrent medical conditions included Penicillin allergy. Concomitant products included PIPERINE, METFORMIN, METOPROLOL, LISINOPRIL, ALLOPURINOL, LEVOTHYROXINE SODIUM (SYNTHROID), LOPERAMIDE, MAGNESIUM CHLORIDE (SLOW MAG [MAGNESIUM CHLORIDE]), ASCORBIC ACID (VIT C), CALCIUM, CYANOCOBALAMIN (B12 [CYANOCOBALAMIN]), COLCHICINE, WARFARIN, ROSUVASTATIN and FENOFIBRATE for an unknown indication.    On 04-Nov-2022, the patient received fifth dose of mRNA-1273 BIVALENT .222 (MODERNA COVID-19 VACCINE, BIVALENT (ORIGINAL AND OMICRON BA.4/BA.5)) (unknown route) 1 dosage form. On 05-Nov-2022, the patient experienced TREMOR (Horrible shaking), FEELING ABNORMAL (Body was feeling miserable) and PYREXIA (Fever/Horrible fever of 105 degree Fahrenheit). On 06-Nov-2022, the patient experienced HYPOAESTHESIA ORAL (Numbness in corner of lips), NECK PAIN (Neck ache), HYPOAESTHESIA (Body started going numb/ felt in finger arm and shoulder/ numbness in toes and foot pad/ numbness is just in the right) and HEADACHE (Head was aching). The patient was treated with PARACETAMOL (TYLENOL) for Fever, at a dose of took 2. At the time of the report, HYPOAESTHESIA ORAL (Numbness in corner of lips) and HYPOAESTHESIA (Body started going numb/ felt in finger arm and shoulder/ numbness in toes and foot pad/ numbness is just in the right) had not resolved and TREMOR (Horrible shaking), FEELING ABNORMAL (Body was feeling miserable), NECK PAIN (Neck ache), PYREXIA (Fever/Horrible fever of 105 degree Fahrenheit) and HEADACHE (Head was aching) outcome was unknown.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On 05-Nov-2022, Body temperature: 105 degree Fahrenheit.         The next day after vaccination, that is on 05-Nov-2022, Patient developed fever and took 2 Tylenols then went through horrible shaking. Patient had horrible fever of 105 degree Fahrenheit and took other 2 Tylenols. On 06-Nov-2022, patient developed numbness which comes and goes. Patient felt it in the corner of lips, then in finger arm, and shoulder. On 07-Nov-2022, patient  felt numbness in toes and foot pad. Patient stated this numbness was just in the right side of the body. It seemed to aggravate, the patient was very concerned because patient's father suffered from a stroke and thought that might be a stroke, so patient visited a physician who told patient since patient was taking blood thinners, patient should not have a stroke. However, patient was concerned because the situation seems to be aggravating.