This case was reported by a consumer via call center representative and described the occurrence of facial pain in a 75-year-old male patient who received Herpes zoster (Shingles vaccine) for prophylaxis. The patient's past medical history included exposure to herbicides (exposed to herbicides). Previously experienced adverse reactions included cancer (cancers due to herbicide exposure). In November 2018, the patient received Shingles vaccine (intramuscular). In November 2018, less than a month after receiving Shingles vaccine, the patient experienced facial pain (serious criteria hospitalization). On 26th November 2018, the patient experienced ear pain (serious criteria hospitalization) and gingival infection (serious criteria hospitalization). On 29th November 2018, the patient experienced red face (serious criteria hospitalization), feeling of warmth facial (serious criteria hospitalization), facial swelling (serious criteria hospitalization), eye discharge (serious criteria hospitalization), rash (serious criteria hospitalization), bloodshot eye (serious criteria hospitalization), eyelid function disorder (serious criteria hospitalization), swelling (serious criteria hospitalization), wound oozing (serious criteria hospitalization), secretion discharge (serious criteria hospitalization), yellow blistering (serious criteria hospitalization) and crust (serious criteria hospitalization). On an unknown date, the patient experienced pharmaceutical product complaint. The patient was treated with Valacyclovir, medication unknown and Antibiotic (Drug Name Unknown). On an unknown date, the outcome of the facial pain, ear pain, gingival infection, red face, feeling of warmth facial, facial swelling, eye discharge, rash, bloodshot eye, eyelid function disorder, swelling, wound oozing, secretion discharge, yellow blistering, crust and pharmaceutical product complaint were unknown. It was unknown if the reporter considered the facial pain, ear pain, gingival infection, red face, feeling of warmth facial, facial swelling, eye discharge, rash, bloodshot eye, eyelid function disorder, swelling, wound oozing, secretion discharge, yellow blistering and crust to be related to Shingles vaccine. Additional details were provided as follows: The patient received unknown SHINGRIX vaccine in an unknown arm in mid of November 2018. On 26th November 2018, the patient thought he had a toothache because the left side of his face and left ear hurt. He went to the dentist, had an x-ray, but nothing was found on the x-ray. The patient was put on an antibiotic because it was thought his gum might be infected. On 29th November 2018, the patient he woke to the left side of his face being red, hot, swollen like a balloon. His left eye was draining, blood shot, and he could barely open it. He had bumps on only the left side of his face extending from his chin up to approximately in inch into his hairline. Some of the bumps were yellow and some were oozing yellow pus and were crusty. The patient went to the emergency room and, after running tests, the patient was admitted to the hospital. The patient still in the hospital and had been started on Valacyclovir and receiving an IV medication. The reporter consented to be followed up. The patient gave permission to have someone call his physician. The reporter did not have the information and would call back to provide additional details.