I have been experiencing swelling in my hand and my extremities, my arm, my hands, my feet, my ankles, my wrist; I have been experiencing swelling in my hand and my extremities, my arm, my hands, my feet, my ankles, my wrist; This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP). The reporter is the patient.  A 56 year-old female patient received bnt162b2 (BNT162B2), intramuscular, administered in arm left, administration date 07Nov2021 (Lot number: FD0809) at the age of 56 years as dose 3 (booster), single for covid-19 immunisation. Relevant medical history included: "Bipolar disorder", start date: 04Sep2001 (ongoing), notes: Verbatim: Bipolar disorder; "Blood cholesterol" (unspecified if ongoing), notes: Verbatim: Cholesterol; "Breast Cancer" (unspecified if ongoing), notes: Tamoxifen was for Breast Cancer treatment. Concomitant medication(s) included: INFLUENZA VACCINE; OLANZAPINE taken for bipolar disorder; LIPITOR taken for blood cholesterol; TAMOXIFEN [TAMOXIFEN CITRATE]; IBUPROFEN; FLUZONE [INFLUENZA VACCINE], administration date 13Oct2021. Vaccination history included: Covid-19 vaccine (Dose 1, Single, Manufacturer unknown, Time: 7:15 AM, Left arm, Intramuscular, Batch/Lot number: ER8737), administration date: 02Apr2021, for Covid-19 Immunization; Covid-19 vaccine (Dose 2, Single, Manufacturer unknown, Time: 7:15 AM, Left arm, Intramuscular, Batch/Lot number: EW0172), administration date: 27Apr2021, for Covid-19 Immunization. The following information was reported: PERIPHERAL SWELLING (non-serious), JOINT SWELLING (non-serious), outcome "unknown" and all described as "I have been experiencing swelling in my hand and my extremities, my arm, my hands, my feet, my ankles, my wrist". Relevant laboratory tests and procedures are available in the appropriate section.  Additional Information: Vaccination facility type was Hospital and 3rd at Pharmacy. Vaccine was not administered at a facility. Patient had lots of lab work done, everything comes back normal (further not clarified). Reporter stated, I tried Ibuprofen (PC filed conservatively) and 'Methotrexate' (medication name further not clarified hence captured as Unspecified medication) and nothing really worked. My doctor is going to be putting me on a low dose diuretic to see if that helps, but I won't be starting that until tomorrow. I was on Tamoxifen, and I stopped taking that in beginning of December (further reason for not taking the medication unknown, hence event captured conservatively as per verbatim) but that's not affecting it either and Tamoxifen was for Breast Cancer treatment. A week and a half after I had the Pfizer booster shot, I have been experiencing swelling in my hand and my extremities, my arm, my hands, my feet, my ankles, my wrist. And my doctor has done a lot of blood work and we have come up empty as to what could be causing this. I even looked at my medication, I had actually gone off medication (Unspecified medication) to see if it was the medication and it wasn't (Event captured as per verbatim conservatively). So the only other thing that's possible is that I am having an adverse reaction to the Pfizer booster shot.   Follow-up attempts are completed. No further information is expected.