Lack of Leg Strength; husband had to help her get in bed by moving her legs upward and then over to be in bed; Cane user; Cough; feeling like they had no more muscle and being incapacitated; Feverish; chills; arm swelling; her arm was hot, swollen and red; her arm was hot, swollen and red; This case was reported by a consumer via call center representative and described the occurrence of mobility decreased in a 82-year-old female patient who received Herpes zoster (Shingrix) (batch number 9H524, expiry date 22nd October 2021) for prophylaxis.   The patient's past medical history included shingles (many years ago before first shingles vaccine several years ago). Previously administered products included Shingles vaccine (received 1st Shingles vaccine several years ago) and Shingrix with an associated reaction of nasopharyngitis (received 1st dose on 29th July 2019, refer linked case).   On 22nd October 2019, the patient received the 2nd dose of Shingrix .5 ml. On 22nd October 2019, less than a day after receiving Shingrix, the patient experienced fever, chills, swelling arm, extremities hot feeling of, erythema of extremities and cough. On an unknown date, the patient experienced mobility decreased (serious criteria disability), lower extremities weakness of, loss of personal independence in daily activities and cane user. Rechallenge with Shingrix was positive. On 1st November 2019, the outcome of the cough was recovered/resolved. On an unknown date, the outcome of the mobility decreased, fever, chills, swelling arm, extremities hot feeling of and erythema of extremities were recovered/resolved and the outcome of the lower extremities weakness of was not recovered/not resolved and the outcome of the loss of personal independence in daily activities and cane user were unknown.   It was unknown if the reporter considered the mobility decreased, fever, chills, swelling arm, extremities hot feeling of, erythema of extremities, cough, lower extremities weakness of, loss of personal independence in daily activities and cane user to be related to Shingrix.  Additional details were provided as follows: Early in the morning, the patient received Shingrix in the left arm and by night felt ill described as feverish, chills, arm swelling, hot and red for approximately 5 to 6 days. Less than 2 months, the patient developed mobility decreased (serious criteria disability), lower extremities weakness of, loss of personal independence in daily activities and cane user. The patient had cough that lasted 9 to 10 days with no sputum and that the cough was not in her chest.  During cough episode, the patient reported lack of leg strength that was unresolved till the time of reporting. The patient's legs felt like they had no more muscle and being incapacitated. The patient's husband had to help her get in bed by moving her legs upward and then over to be in bed. The incapacity lasted approximately 2-3 days and mentioned using a cane for those few days although she could still walk. The patient states ever since episode her legs have not felt right and her legs get tired very easily and quickly.  During phone call, the patient was reportedly standing up but had to sit down during conversation due to leg tiredness. The reporter consented to follow up.