Severe alergic reaction; had a sore throat off & on the whole time; it felt like my throat was closing; Little itchy rash patch under my chin; I have a rash all over my body, & a swollen face; I vomited; My sense of taste is off; Migraine; This spontaneous case was reported by a patient (subsequently medically confirmed) and describes the occurrence of HYPERSENSITIVITY (Severe alergic reaction), AGEUSIA (My sense of taste is off), MIGRAINE (Migraine), OROPHARYNGEAL PAIN (had a sore throat off & on the whole time) and THROAT TIGHTNESS (it felt like my throat was closing) in a 34-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 046A21A and 032B21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     The patient's past medical history included Rosacea.   On 23-Mar-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 21-Apr-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 23-Mar-2021, the patient experienced AGEUSIA (My sense of taste is off), MIGRAINE (Migraine), RASH PRURITIC (Little itchy rash patch under my chin), RASH (I have a rash all over my body, & a swollen face) and VOMITING (I vomited). On 28-May-2021, the patient experienced OROPHARYNGEAL PAIN (had a sore throat off & on the whole time) and THROAT TIGHTNESS (it felt like my throat was closing). On 08-Jun-2021, the patient experienced HYPERSENSITIVITY (Severe alergic reaction). The patient was treated with HYDROCORTISONE for Adverse event, at an unspecified dose and frequency; CETIRIZINE HYDROCHLORIDE (ZYRTEC [CETIRIZINE HYDROCHLORIDE]) for Adverse event, at an unspecified dose and frequency; IBUPROFEN, PSEUDOEPHEDRINE HYDROCHLORIDE (ADVIL COLD & SINUS) for Adverse event, at an unspecified dose and frequency; PREDNISONE from 05-May-2021 to 09-May-2021 for Adverse event, at an unspecified dose and frequency; FLUCONAZOLE from 21-May-2021 to 27-May-2021 for Adverse event, at a dose of 200 milligram; ERYTHROMYCIN from 10-May-2021 to 30-May-2021 for Rash, at a dose of 250 milligram twice a day and PREDNISONE from 28-May-2021 to 06-Jun-2021 for Rash, at an unspecified dose and frequency. At the time of the report, HYPERSENSITIVITY (Severe alergic reaction), AGEUSIA (My sense of taste is off), MIGRAINE (Migraine), OROPHARYNGEAL PAIN (had a sore throat off & on the whole time), THROAT TIGHTNESS (it felt like my throat was closing), RASH PRURITIC (Little itchy rash patch under my chin), RASH (I have a rash all over my body, & a swollen face) and VOMITING (I vomited) outcome was unknown.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On 08-Jun-2021, Biopsy skin: abnormal (abnormal) It was a Covid-19 vaccine hypersensitivity reaction with interstitial granulomatous features & also a component of photo irritant & photoallergic dermatitis. Antigenic trigger of this type ID immune response is unclear, but human myocyte manufactured foreign spike glycoprotein is possible..     For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown), the reporter did not provide any causality assessments.   No concomitant medication was reported.  On 05 May 2021, the patient was seen at an Urgent Care for a rash and a sinus infection. After 5 days of treatment with the prednisone, all symptoms stopped.  On 10 May 2021, the rash came back and the patient contacted the dermatologist regarding the rash spreading to the collar bone, chest, shoulder, upper arm, and back.  On 28 May 2021,  the patient went back to the Urgent Care for progressing symptoms. The patient was treated again with another round of prednisone which cleared up some of the rash.  On an unknown date, the patient reported seeing an ENT (Ear, Nose, and Throat) doctor who found the patient's throat to be swollen and inflamed.  On 01 Jun 2021, the patient consulted the dermatologist again and had a biopsy done for the rash. Results from the biopsy returned on 08 Jun 2021 and the patient was to send in the report.; Sender's Comments:  MOD-2021-213251:Dose 1