Pustules that became sunken into his skin; pain was so severe from the swollen lymph node in the back of his head; could not sleep; pain was so severe from the swollen lymph node in the back of his head; Bacterial infection; Pustules that became sunken into his skin; diagnosed the lesions as Shingles; they did burn/burning from lesions; lymph node on the back of his neck and in his groin area became inflamed; This non-serious case was reported by a consumer via call center representative and described the occurrence of shingles in a 67-year-old male patient who received Herpes zoster (Shingrix) for prophylaxis.   On 09-APR-2023, the patient received the 1st dose of Shingrix. On 11-APR-2023, 2 days after receiving Shingrix, the patient experienced shingles (Verbatim: diagnosed the lesions as Shingles) and burning sensation (Verbatim: they did burn/burning from lesions). In APR-2023, the patient experienced swollen lymph nodes (Verbatim: lymph node on the back of his neck and in his groin area became inflamed). On an unknown date, the patient experienced pustular rash (Verbatim: Pustules that became sunken into his skin), headache (Verbatim: pain was so severe from the swollen lymph node in the back of his head), insomnia (Verbatim: could not sleep), lymph node pain (Verbatim: pain was so severe from the swollen lymph node in the back of his head), bacterial infection (Verbatim: Bacterial infection) and skin disorder (Verbatim: Pustules that became sunken into his skin). The patient was treated with paracetamol (Tylenol), valaciclovir (Valacyclovir) and doxycycline. The outcome of the shingles, burning sensation and swollen lymph nodes were not resolved and the outcome of the pustular rash, headache, insomnia, lymph node pain and skin disorder were unknown and the outcome of the bacterial infection was not reported.   It was unknown if the reporter considered the shingles, burning sensation, swollen lymph nodes, pustular rash, headache, insomnia, lymph node pain, bacterial infection and skin disorder to be related to Shingrix.   It was unknown if the company considered the shingles, burning sensation, swollen lymph nodes, pustular rash, headache, insomnia, lymph node pain, bacterial infection and skin disorder to be related to Shingrix.   Additional Information: GSK Receipt Date: 01-JUN-2023 The reporter stated that he received the Shingrix.  The reporter reported that 37-48 hours later he began breaking.  The first lesion was located on his left wrist.  The lesions spread to his chin, left ear and then his right side (under the arm and his buttocks). The reporter stated the lesions did not itch but they did burn.  He described the lesions as being the size of a penny and some being the size of an ingrown hair. The reporter stated the lesions were from his knees to the top of his head. He went to a dermatologist who biopsied the lesions on the second or third visit diagnosed the lesions as Shingles. The lesions ultimately developed into pustules that became sunken into his skin. The lesions that were tested positive for shingles are located on both the left and right side of the body. The consumer also stated that a lymph node on the back of his neck and in his groin area became inflamed.  The reporter stated that the pain was so severe from the swollen lymph node in the back of his head that he wanted to cry and could not sleep. The dermatologist initially prescribed Valacyclovir for the lesions. When the lesions continued to spread and involved swollen lymph nodes the dermatologist prescribed Doxycycline for a bacterial infection.  The reporter was prescribed Tylenol for the pain from the lymph node in the back of his head. The consumer had appointment next week to see an infectious disease specialist. The reporter consented to follow up.