Psoriatic arthritis; Entire head was burning; Lost hair/hair started falling out; Huge swollen lumps; Pain in her head; This spontaneous case was reported by a consumer and describes the occurrence of PSORIATIC ARTHROPATHY (Psoriatic arthritis) in a 42-year-old female patient who received mRNA-1273 (Spikevax) (batch no. unknown) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     The patient's past medical history included Complex regional pain syndrome (She has a history of Complex Regional Pain Syndrome (CRPS) and was diagnosed when she was 28 years old.).    On an unknown date, the patient received second dose of mRNA-1273 (Spikevax) (unknown route) 1 dosage form. On an unknown date, the patient experienced PSORIATIC ARTHROPATHY (Psoriatic arthritis) (seriousness criterion medically significant), SKIN BURNING SENSATION (Entire head was burning), ALOPECIA (Lost hair/hair started falling out), SWELLING (Huge swollen lumps) and HEADACHE (Pain in her head). At the time of the report, PSORIATIC ARTHROPATHY (Psoriatic arthritis), SKIN BURNING SENSATION (Entire head was burning), ALOPECIA (Lost hair/hair started falling out), SWELLING (Huge swollen lumps) and HEADACHE (Pain in her head) outcome was unknown.            Concomitant product use was not provided by the reporter.  The patient received 3 doses of Moderna vaccine. After her second dose she experienced entire head was burning, had pain in her head, and lost hair. She had huge swollen lumps and after they went away when her hair started falling out. She saw a rheumatologist and was told it was possible she had psoriatic arthritis and wanted to put her on Plaquenil. She refused to take that medication. She has had a telehealth appointment with her NP 31-Mar-2022. She had her ketamine infusion on 29-Mar-2022 and was hoping that will help with the inflammation she already got with CRPS and possibly the pain in her head. Caller was thankful for the vaccine and says if she did not have it, she would be dead. CC: This spontaneous case concerns a 42-year-old female patient with medical history of Complex regional pain syndrome, which experienced the serious (due to medically significant), unexpected event of psoriatic arthritis and other non-serious events, which occurred on an unknown date after the 2nd dose of the mRNA-1273 vaccine. She reported that after the 2nd dose her entire head was burning, had pain in her head and lost her hair. She had huge swollen lumps and after they went away is when her hair started falling out. The rheumatologist said it was possible she had psoriatic arthritis and indicated Plaquenil but she refused to take it. She had an appointment for ketamine infusion. The mentioned medical history remains a confounder for the non-serious events of skin burning, swelling, headache and alopecia. The benefit-risk relationship of the mRNA-1273 vaccine is not affected by this report.; Sender's Comments: This spontaneous case concerns a 42-year-old female patient with medical history of Complex regional pain syndrome, which experienced the serious (due to medically significant), unexpected event of psoriatic arthritis and other non-serious events, which occurred on an unknown date after the 2nd dose of the mRNA-1273 vaccine. She reported that after the 2nd dose her entire head was burning, had pain in her head and lost her hair. She had huge swollen lumps and after they went away is when her hair started falling out. The rheumatologist said it was possible she had psoriatic arthritis and indicated Plaquenil but she refused to take it. She had an appointment for ketamine infusion. The mentioned medical history remains a confounder for the non-serious events of skin burning, swelling, headache and alopecia. The benefit-risk relationship of the mRNA-1273 vaccine is not affected by this report.