his IgA was 35 mg/dl. The normal range is 100 to 200 something mg/dl/ His Ig level have been consistently dropping.; This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP) from medical information team. The reporter is the patient.  A 74-year-old male patient received BNT162b2 (BNT162B2), as dose 4 (booster), single (Batch/Lot number: unknown) for covid-19 immunisation. The patient's relevant medical history included: "he has smouldering myeloma" (unspecified if ongoing), notes: he has smouldering myeloma. There were no concomitant medications. Vaccination history included: Bnt162b2 (dose 1, he received 5 of the Pfizer covid vaccines, 3 regular and 2 booster doses), for Covid-19 Immunization, reaction(s): "his IgA was 35 mg/dl. The normal range is 100 to 200 something mg/dl/ His Ig level have been consistently dropping"; Bnt162b2 (dose 2, he received 5 of the Pfizer covid vaccines, 3 regular and 2 booster doses), for Covid-19 Immunization, reaction(s): "his IgA was 35 mg/dl. The normal range is 100 to 200 something mg/dl/ His Ig level have been consistently dropping"; Bnt162b2 (dose 3, he received 5 of the Pfizer covid vaccines, 3 regular and 2 booster doses), for Covid-19 Immunization, reaction(s): "his IgA was 35 mg/dl. The normal range is 100 to 200 something mg/dl/ His Ig level have been consistently dropping.". The following information was reported: BLOOD IMMUNOGLOBULIN A DECREASED (medically significant), outcome "not recovered", described as "his IgA was 35 mg/dl. The normal range is 100 to 200 something mg/dl/ His Ig level have been consistently dropping.". The patient underwent the following laboratory tests and procedures: Blood immunoglobulin A (100-200): (12Dec2022) 35 mg/dl, notes: The normal range is 100 to 200 something mg/dl; Immunoglobulins decreased: (Dec2022) level was consistently dropping. Course of events: Patient received 5 of the Pfizer covid vaccines, 3 regular and 2 booster doses. His most recent was 05Dec2022, his card says Pfizer GJ3274. His IGA decreased, and he wants someone to talk too regarding his concern. He took no medication. He was in decent shape and went to an oncologist because he had smouldering myeloma. It was not active but he had to have labs every 5-6 months and they follow him to make sure there are no spikes in immunoglobulins. On 12Dec2022 his last lab result for his IgA was 35 mg/dl. The normal range is 100 to 200 something mg/dl. This all correlated with the span of the vaccines he received. His Ig level have been consistently dropping. In his research he found that in general these vaccines are supposed to increase levels of IgG and IgA. He has been doing research and online it mentions possible reduction in IgA levels and that some people that have low levels of IgA, or selective IgA deficiency, do not respond to the injection. He was not an immunocompromised individual. He called his doctor but they do not know the answer to his question. The reporter noticed there was a drop in his IgA levels and wanted to know if there was a correlation with the Pfizer vaccines affecting the IgA levels.  No follow-up attempts are possible; information about lot/batch number cannot be obtained. No further information is expected.; Sender's Comments: Based on the information currently available, a possible contributory role of the suspect drug in the reported event Blood immunoglobulin A decreased cannot be completely ruled out given the implied temporal association. The impact of this report on the benefit/risk profile of the Pfizer product is evaluated as part of Pfizer procedures for safety evaluation, including the review and analysis of aggregate data for adverse events. Any safety concern identified as part of this review, as well as any appropriate action in response, will be promptly notified to Regul atory Authorities, Ethics Committees and Investigators, as appropriate.