This spontaneous case was reported by a patient and describes the occurrence of PRURITUS (Skin itching in the bottom of hand/itching in the feet), ERYTHEMA (Redness in the hands), PERIPHERAL SWELLING (Swollen hands/swollen feet), DYSPNOEA (The patient had trouble breathing) and DYSPEPSIA (Felt like heart burn) in a 64-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch no. 014B22A) for COVID-19 prophylaxis. The occurrence of additional non-serious events is detailed below. The patient's past medical history included COVID-19 (infection) in January 2022. Previously administered products included for Product used for unknown indication: Pfizer vaccine (First dose, Batch Number: EN6208 and route: intramuscular) on 10-Mar-2021, Pfizer vaccine (Second dose, Batch Number: ER8737) on 31-Mar-2021, Pfizer vaccine (First booster dose and Batch Number: FH8028) on 20-Nov-2021. Past adverse reactions to the above products included No adverse event with Pfizer vaccine, Pfizer vaccine and Pfizer vaccine. Concurrent medical conditions included Drug allergy (Cortisone) and Thyroid disorder NOS. Concomitant products included LEVOTHYROXINE for Thyroid disorder NOS. On 08-Aug-2022, the patient received fourth dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 10-Aug-2022, the patient experienced PRURITUS (Skin itching in the bottom of hand/itching in the feet), ERYTHEMA (Redness in the hands), PERIPHERAL SWELLING (Swollen hands/swollen feet), DYSPNOEA (The patient had trouble breathing), DYSPEPSIA (Felt like heart burn) and CHEST DISCOMFORT (Pressure in chest). On 12-Aug-2022, the patient experienced DRY SKIN (The patient still felt dry skin even if it was not). The patient was treated with DIPHENHYDRAMINE HYDROCHLORIDE (BENADRYL [DIPHENHYDRAMINE HYDROCHLORIDE]) at an unspecified dose and frequency and ALBUTEROL [SALBUTAMOL] (inhalation use) at an unspecified dose and frequency. On 12-Aug-2022, PRURITUS (Skin itching in the bottom of hand/itching in the feet), ERYTHEMA (Redness in the hands) and PERIPHERAL SWELLING (Swollen hands/swollen feet) had resolved. At the time of the report, DYSPNOEA (The patient had trouble breathing), DYSPEPSIA (Felt like heart burn), CHEST DISCOMFORT (Pressure in chest) and DRY SKIN (The patient still felt dry skin even if it was not) had not resolved. The patient medical history was not related to mentioned adverse events and not with both acute and chronic illnesses at the time of vaccination. The patient was not given other vaccines within one month prior to Moderna COVID-19 vaccine. The patient had not a history of myocarditis/pericarditis. It was reported that two days after the second booster, the patient experienced an extreme side effect such as skin itching in the bottom of hand, redness, swollen, and feet were also started itching and were swelled, the patient still felt skin dry even if it was not because the patient moisturized it. The itchiness was gone, pressure comes and goes. The patient was thinking about visit emergency room. The adverse events had not caused patient to seek medical care, but the patient visited to primary HCP (health care professional). For cardiac symptoms, primary HCP recommended patient to visit a cardiologist. Treatment information included the patient had Benadryl, inhaler Albuterol, nebulizer for pressure in chest, felt like a burning heart, trouble breathing and moisturizer for dry skin. No treatment was specified for rest events. The patient not had tests of cardiac lab values (electrocardiogram, cardiac test, cardiac enzymes) and not had a test of positive COVID-19 test.