rash / itch / felt like my throat had closure in it / they diagnosed me with urticaria /; Dermotographic urticaria/swelling and the itching; lethargic; Didn't feel good overall; congested; had chills; This spontaneous case was reported by an other health care professional and describes the occurrence of URTICARIA (rash / itch / felt like my throat had closure in it / they diagnosed me with urticaria / ), MECHANICAL URTICARIA (Dermotographic urticaria/swelling and the itching), LETHARGY (lethargic), MALAISE (Didn't feel good overall) and NASAL CONGESTION (congested) in a 50-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch no. 026L20A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     No relevant medical history was provided by the reporter.  Concomitant products included CETIRIZINE HYDROCHLORIDE (ZYRTEC ALLERGY) for Allergy, OMEPRAZOLE for an unknown indication.    On 05-Nov-2021, the patient received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 08-Nov-2021, the patient experienced LETHARGY (lethargic), MALAISE (Didn't feel good overall), NASAL CONGESTION (congested) and CHILLS (had chills). On 15-Nov-2021, the patient experienced URTICARIA (rash / itch / felt like my throat had closure in it / they diagnosed me with urticaria / ) and MECHANICAL URTICARIA (Dermotographic urticaria/swelling and the itching). The patient was treated with FAMOTIDINE (PEPCID AC) on 15-Nov-2021 for Adverse event, at an unspecified dose and frequency; PREDNISONE on 15-Nov-2021 for Adverse event, at an unspecified dose and frequency and EPINEPHRINE (EPIPEN) on 15-Nov-2021 for Adverse event, at an unspecified dose and frequency. At the time of the report, URTICARIA (rash / itch / felt like my throat had closure in it / they diagnosed me with urticaria / ), MECHANICAL URTICARIA (Dermotographic urticaria/swelling and the itching), LETHARGY (lethargic), MALAISE (Didn't feel good overall), NASAL CONGESTION (congested) and CHILLS (had chills) outcome was unknown.        For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown), the reporter did not provide any causality assessments.   08-Nov-2021, patient felt lethargic, had chills, was congested, & did not feel good overall. On 15-Nov-2021, patient developed a rash, which started on my neck and head, then continued all over her body, even in the palms of her hands. There would be a place that itched, and when she scratched it, it would turn into a rash. 15-Nov-2021, she also went to the emergency room. It felt like her throat had closure in it. She was prescribed with one dose of Pepcid while she was there. she also got a prescription for titrating doses of prednisone (40 pills). She was diagnosed with urticaria and they felt like the rash was from food or a plant, they were not really sure. She was also given a EpiPen. On 23-Nov-2021, patient saw primary care physician. He took pictures and did some blood work. He referred her to an allergist. On 29-Nov-2021, patient saw the allergist. He was diagnosed with the rash as Dermotographic urticaria. She was given with a prescription for Hydroxyzine for the swelling & the itching.   This case was linked to MOD-2021-403240, MOD-2021-402910 (Patient Link).