bullous eruption/bulla approx. 3 cm/ center of bulla was necrotic; the center of the bulla was necrotic; blister on the lip; bulla was approx. 3 cm and will likely leave a scar (is now a healing eschar); eruption on the upper Cutaneous lip that looked like HSV; malaise; fever; myalgia; Scar; This case was reported by a other health professional and described the occurrence of bullous eruption in a female patient who received Herpes zoster (Shingrix) for prophylaxis.   Co-suspect products included Flu Seasonal QIV Dresden (Influenza vaccine Quadrivalent unspecified season) for prophylaxis and PNEUMOCOCCAL VACCINE for prophylaxis.   On an unknown date, the patient received the 1st dose of Shingrix, Influenza vaccine Quadrivalent unspecified season and PNEUMOCOCCAL VACCINE. On an unknown date, 1 week after receiving Shingrix and Influenza vaccine Quadrivalent unspecified season, the patient experienced bullous eruption (serious criteria GSK medically significant), necrosis (serious criteria GSK medically significant), lip blister, eschar, herpes simplex, malaise, fever, myalgia and scar. The patient was treated with dermatologicals nos (Ointment). On an unknown date, the outcome of the bullous eruption, necrosis, lip blister, eschar, herpes simplex, malaise, fever, myalgia and scar were unknown.   It was unknown if the reporter considered the bullous eruption, necrosis, lip blister, eschar, herpes simplex, malaise, fever, myalgia and scar to be related to Shingrix and Influenza vaccine Quadrivalent unspecified season.  Additional details were provided as follows: The age at vaccination was not reported. The patient received Shingrix, influenza vaccine and Pneumococcal vaccine on an unknown arm. After receiving Shingrix, influenza vaccine and Pneumococcal vaccine, the patient had a bullous eruption at a site distant to the vaccine.  The bulla was approximately 3 cm and would likely leave a scar and was healing eschar at the time of reporting.  The reporter did see it when it was bullous and could confirm.  The patient also had some eruption on the upper cutaneous lip that looked like HSV which was treated.  The patient also experienced malaise, fever, myalgia in the 2 to 3 days postvaccination. She also received quadrivalent flu vaccine and pneumococcal vaccine at the same time. I confirmed with that patient that the vaccines were all in the arms, not in the glut muscle where she has had the reaction.  The patient denied spider bite or having seen a spider and history of staphylococcal infection. The patient was a good historian. The reporter was asking if the patient would have 2nd dose. Healthcare professional followed up with Medical Information and provides the additional information. The center of the bulla was necrotic.  The blister was drained and treated with ointment.  There were pictures available if safety would like to follow up.  The blister on the lip and the bulla appeared approximately a week after vaccination.  Healthcare professional denied the patient history of autoimmune disorders or immune-mediated diseases, stating if anything the patient's immune response might be too strong. No additional details were provided. This case was linked with case US2020AMR178605, reported by the same reporter.; Sender's Comments:  US-GLAXOSMITHKLINE-US2020AMR178605:same reporter