Around mid-year, the lymph nodes in my right armpit were swollen.; This spontaneous case was reported by a patient and describes the occurrence of LYMPHADENOPATHY (Around mid-year, the lymph nodes in my right armpit were swollen.) in a 63-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 prophylaxis.     Family history included Leukemia (Blood cancer runs in family.). Concurrent medical conditions included Immunocompromised and Thalassemia.   On 31-Dec-2020, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 28-Jan-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. In 2021, the patient experienced LYMPHADENOPATHY (Around mid-year, the lymph nodes in my right armpit were swollen.) (seriousness criterion hospitalization). At the time of the report, LYMPHADENOPATHY (Around mid-year, the lymph nodes in my right armpit were swollen.) had not resolved.            Concomitant Medication use information was not provided by reporter.  Patient did not experience a similar event in the past.  The patient reported that the symptoms were worsened.   Her doctor had done all kinds of test and blood work and said patient was fine.  The patient reported that AE caused her to seek medical care (office visit, Urgent care, ER, hospitalized).  Treatment Medication use information was not provided by reporter.  Company comment: This spontaneous case concerns a 63-year-old female patient with relevant medical history of Immunocompromised and Thalassaemia who experienced the unexpected, serious (Hospitalization) event of Lymphadenopathy(Lymphadenopathy axillary)  that occurred unknown days after receiving the second dose of mRNA-1273 Vaccine. It was reported that around mid-year patient experienced swollen lymph nodes in the right axilla. Family history of Leukaemia was also noted. Patient had also received the first dose (29 days prior to second dose), first booster and second booster dose of the same vaccine. No further information on concomitant medications, lab results and treatment received were provided. The outcome of the event was not recovered at the time of report. Patients' history of immunocompromised and Thalassaemia, family history of leukaemia could be confounders for the event lymphadenopathy. The benefit-risk relationship of mRNA-1273 Vaccine is not affected by this report.   This case was linked to MOD-2022-647027, MOD-2022-647026 (Patient Link).; Sender's Comments: This spontaneous case concerns a 63-year-old female patient with relevant medical history of Immunocompromised and Thalassaemia who experienced the unexpected, serious (Hospitalization) event of Lymphadenopathy(Lymphadenopathy axillary)  that occurred unknown days after receiving the second dose of mRNA-1273 Vaccine. It was reported that around mid-year patient experienced swollen lymph nodes in the right axilla. Family history of Leukaemia was also noted. Patient had also received the first dose (29 days prior to second dose), first booster and second booster dose of the same vaccine. No further information on concomitant medications, lab results and treatment received were provided. The outcome of the event was not recovered at the time of report. Patients' history of immunocompromised and Thalassaemia, family history of leukaemia could be confounders for the event lymphadenopathy. The benefit-risk relationship of mRNA-1273 Vaccine is not affected by this report.