Information has been received from a doctor's office staff concerning an 83 year old female with drug allergies to ZOLOFT and SEPTRA who on 01-NOV-2010 was vaccinated IM with PNEUMOVAX 23, 0.5ml (lot # 667692/1110Z). Concomitant therapy included ACTONEL, amlodipine besylate (+) benzapril hydrochloride, meclizine, metoprolol succinate, tramadol HCl, HCTZ/triamterene and TYLENOL extra strength. On 02-NOV-2010 (next day) while at her husband's doctor's appointment the patient was told they thought her arm was red and swollen. She saw her doctor on 02-NOV-2010 with right arm pain and was unable to lie on that side. The area was swollen, warm to touch and red from below the elbow to the shoulder. She thought the redness and pain had improved from the day before. Lab diagnostics studies were not performed. Treatment given for the events included ice packs. At the time of reporting, the outcome was unknown. It was unknown if the patient received PNEUMOVAX 23 in the past. Information has been received from medical records and an RN regarding an 83 yr old female with ZOLOFT ("weird feeling") and SEPTRA (glossitis) allergies, essential hypertension, somatic dysfunction, thinning of hair from BP medication, heavy caffeine use (4-9 8oz cups/day) and a history of appendectomy, breast biopsy, colonoscopy, gallbladder surgery, hysterectomy with ovaries removed, right and left eye implants and a family history of Alzheimer's and CABG (father) who on 01NOV2010 was vaccinated IM with PNEUMOVAX 23, 0.5 ml (lot # 667692/1110Z). Concomitant therapy included ACTONEL, amlodipine besylate (+) benazepril hydrochloride, meclizine, metoprolol succinate, tramadol HCl, HCTZ/triamterene and TYLENOL extra strength. On 03NOV2010, pt seen with complaints of allergic reaction to AFLURIA injection. The patient's right arm was swollen, red and warm to touch from below the elbow to the shoulder. After receiving the vaccine, the patient really did not notice much about it herself, other than it was a little tender and she could not lie on that side. She was at her husband's doctor's appointment, and they commented on how red and sore her arm was. She acknowledged that the redness was significantly improved from the previous day and the pain was improving. She had not taken anything or done anything other than ice. She had no shortness of breath or respiratory problems.  No prior history of reactions to infections or medications like this. Assessment includes acute allergic reaction and rash, nonvesicular. The patient was to watch closely over the next few days. The patient was instructed to never receive another pneumonia vaccine. On 08NOV2010, the patient was seen for recheck after AFLURIA reaction and being on blood pressure medicine. Assessment included tolerating new blood pressure medication without difficulty and was still having the same problem with hair loss. Her arm is much improved. Patient was to decrease her beta blocker a little bit. The physician was not convinced that her hair loss was related to drugs, but may just be age-related. It was reported that the patient recovered by 08NOV2010. This is one of several reports received from the same source. All available medical records will be provided upon request. Additional information has been requested.