Evan received his first Hepatitis B vaccine at 1 day old at Pennsylvania Hospital. He received the 1 month as above and the third on schedule. He made all his developmental milestones and next developed progressive autistic tendencies that were not fully diagnosed until he was 12 years old. He developed GI,cognitive and developmental coordination problems associated with autism and perhaps brain damage. We think this may be related to this vaccine. Individuals who get Hepatitis can get a similar problems affecting the Central and peripheral nervous system with damage noted at autopsy. We see that there are reports that some forms of regressive autism are autoimmune. Part of the mechanism involves TNF. Different immune types may respond differently to immunization. In our family, there is a high penetrance of Rheumatoid arthritis which is a TNF related disease. I have been forced to create an irrelevant date for onset as there is little data to support this process as of yet but we feel there is a direct correlation. We have 2 Neurotypical(not damaged)children who did not receive this vaccine. Evan has had a progressive decline in motor and cognitive skills associated with a gastrointestinal reaction. We see there have been studies of preservatives but what about the immune reaction that these vaccines can cause.  Our sons life is severely impaired and so are our families as we struggle with inadequate resources to try to make him functional in society. We have watched a progressive cognitive and functional decline which has been diagnosed as autism by 1 Neurologist,1 Psychiatrist and 6 Psychologists. We understand children with Autism who incidentally went to autopsy have had an autoimmune attack on the CNS like in ? PAN. Have primates been studied to see if they develop autism on the US immunization schedule?  I heard there was a report but can't find it. What was the time of onset of autism in other primates? 7/14/08-records received for DOS 2/14/06-Nonverbal learning disability and difficuluties with executive function. Asperger's syndrome.  11/14/08-record received for DOS 2/14/06-neurology consult for C/O headaches and need to have consultation regarding possible learning disability, specifically nonverbal learning disability. DX Migraine. Asperger's syndrome. Tension headache. Follow-up: Subtle cognitive impairment was noted early in childhood. Associated causality could not be incriminated. Date of vaccination with Hep B-day 1. None of his siblings had this vaccination as we were offered consent on his brother in 1990 and declined as it was new. No sibling has cognitive brain disorder and neurologic sequel resembling Autism. Patient had subtle neurological abnormalities that surfaced in early childhood but no diagnosed PDD-NOS. He illustrated mild learning disabilities both socially and in attention as well as mild motor impairment. His siblings have no disorder. His high IQ was impaired by his disabilities. We believe that his vaccination may have induced an inflammatory CNS event that was further aggravated with subsequent immunizations. We had no reason to suspect a complication on the day of immunizations as we were not advised to look for any problems and could not report this in a timely fashion. There is a disconnect between the Hospitals that administered the vaccine, the Primary Pediatrician, and follow up looking for a problem. However, when patient had a profound cognitive and motor coordination, sensory processing decline after the TDAP and a high fever, we as 2 physicians became convinced that the vaccination was causal. This will be described in the VAERS report with ID 315636. Both a Board Certified Allergist and Immunologist and Cardiologist/Internal Medicine who has done Rheumatologist research have serious concerns that in some genetically predisposed individuals a form of CNS vasculitis or inflammation can develop after Hepatitis B infection that is related to an aberrant immune response to this agent-Polyarteritis Nodosa. The same type of pathology could occur with immunization leading to brain damage in children receiving this vaccination. Generally and Phenotypically, this was an unnecessary immunization for our child as he was not at risk for hepatitis B. This vaccination could have been delayed until the year before school when issues of cognitive function or other side effects could be more clearly observed if it was felt that this vaccination is a mandate for public health. Perhaps our genotype may be more likely to overreact to an adjuvant given with an infectious agent and produce an aberrant response such as damage to the brain or neural communication. This specifically was not adequate studied prior to this immunization protocol at 1 day of age to exclude a population variance. There are many other comments and concerns to discuss and we feel that the reporting system has unfair in responding in a timely fashion and that the consent form as given is not clear as to possible side effects that may occur with vaccination. We would like follow up with this report. We have been advised that this is a separate agency from the one that deals with compensation for permanently disabled individuals. We do not think the current forms or information addressed to Pediatricians makes them realize the potential for side effects or aids in fair reporting to prevent devastating side effects for the individual or others perhaps at risk too. Our son is disabled now.