every time he gets the vaccine less than two weeks later he gets indentations on both legs; gets minor leg issues and circulation issues but no clots/every time he gets the vaccine less than two weeks later he gets indentations on both legs; when he gets the vaccine he would get a headache, no fever, chills, and really tired.; when he gets the vaccine he would get a headache, no fever, chills, and really tired.; when he gets the vaccine he would get a headache, no fever, chills, and really tired.; it hit him really hard and he was asleep within the hour; had aches and pains; did not feel right; This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP) from medical information team, Program ID: (159558). The reporter is the patient.  A 57-year-old male patient received BNT162b2 (BNT162B2), on 29Jul2022 as dose 4 (booster), single (Batch/Lot number: unknown) for covid-19 immunisation. The patient's relevant medical history and concomitant medications were not reported. Vaccination history included: Bnt162b2 (Dose 1, single), for COVID-19 Immunization, reaction(s): "when he gets the vaccine he would get a headache, no fever, chills, and really tired.", "when he gets the vaccine he would get a headache, no fever, chills, and really tired.", "when he gets the vaccine he would get a headache, no fever, chills, and really tired.", "gets minor leg issues and circulation issues but no clots/every time he gets the vaccine less than two weeks later he gets indentations on both legs", "gets minor leg issues and circulation issues but no clots/every time he gets the vaccine less than two weeks later he gets indentations on both legs"; Bnt162b2 (Dose 2, single), for Covid-19 immunization, reaction(s): "when he gets the vaccine he would get a headache, no fever, chills, and really tired.", "when he gets the vaccine he would get a headache, no fever, chills, and really tired.", "when he gets the vaccine he would get a headache, no fever, chills, and really tired.", "gets minor leg issues and circulation issues but no clots/every time he gets the vaccine less than two weeks later he gets indentations on both legs", "gets minor leg issues and circulation issues but no clots/every time he gets the vaccine less than two weeks later he gets indentations on both legs"; Bnt162b2 (DOSE 3 (BOOSTER), SINGLE), administration date: Nov2021, for Covid-19 immunization, reaction(s): "when he gets the vaccine he would get a headache, no fever, chills, and really tired.", "when he gets the vaccine he would get a headache, no fever, chills, and really tired.", "when he gets the vaccine he would get a headache, no fever, chills, and really tired.", "gets minor leg issues and circulation issues but no clots/every time he gets the vaccine less than two weeks later he gets indentations on both legs", "gets minor leg issues and circulation issues but no clots/every time he gets the vaccine less than two weeks later he gets indentations on both legs". The following information was reported: SKIN INDENTATION (non-serious), outcome "unknown", described as "every time he gets the vaccine less than two weeks later he gets indentations on both legs"; PERIPHERAL VASCULAR DISORDER (non-serious), outcome "unknown", described as "gets minor leg issues and circulation issues but no clots/every time he gets the vaccine less than two weeks later he gets indentations on both legs"; HEADACHE (non-serious), CHILLS (non-serious), FATIGUE (non-serious), outcome "unknown" and all described as "when he gets the vaccine he would get a headache, no fever, chills, and really tired."; SOMNOLENCE (non-serious), outcome "unknown", described as "it hit him really hard and he was asleep within the hour"; PAIN (non-serious), outcome "unknown", described as "had aches and pains"; FEELING ABNORMAL (non-serious), outcome "unknown", described as "did not feel right". Relevant laboratory tests and procedures are available in the appropriate section.  Additional information: Reporter (Patient) stated he has had 2 Pfizer covid 19 vaccines and 2 Pfizer covid 19 booster shots noting that he had the last vaccine in November and the 2nd booster dose this past Friday, 29Jul2022. Patient (Pt) stated he has had 4 vaccines in less than 2 years and stated every single time he gets the vaccine he has the same side effects and in a couple of days he is back to normal. Pt asked is that the standard and can the vaccine affect the kidneys and the heart, what are the long-term effects on his body and the short-term effects. Pt stated he gets minor leg issues and circulation issues but no clots and stated every time he gets the vaccine less than two weeks later he gets indentations on both legs and it comes and goes throughout the day and goes away in a month. Pt stated his HCP does not know what it could be and reported that when he gets the vaccine he would get a headache, no fever, chills, and really tired. Pt stated he got the vaccine at 4 PM on Friday and he slept Friday night, Saturday, Saturday night and Sunday morning and then he was back to normal like he did not get the vaccine. Pt reported the 4th dose was worse than the first three, but he was prepared, drank fluids, took tylenol and rested. Pt stated he was so tired from the vaccine saying it was intense, unbelievable and something else and stated it knocked him for a loop. Pt stated he had a headache before he got home from # where he got the vaccine, it hit him really hard, and he was asleep within the hour. Pt reported he had no fever, had aches and pains, did not feel right and then his body clicked back to normal like it always does and stated he did not talk to anyone until he felt better. Pt stated he feels fine now. Pt asked if the fact that he is having this reaction is positive that the vaccine is working and stated this is very stressful putting this medication in to his body. Pt stated he had a friend in her 30's and had to stop working with the # police because the vaccine affected her kidneys, her lungs and the lining of her heart and stated she was fine before the vaccine. Pt stated he does not want template information that the agent will read off of prescribed mumbo jumbo. Caller stated Pfizer is in business with the CDC and the government and he feels that Pfizer has not released the information about what it can do to someone's organs. Pt stated he wants the truth. Pt stated he is frustrated with the process and had been on the phone for 33 minutes and stated it is morally unethical to put this medication in his body.Immunogenicity of a Second Booster Dose included Immunogenicity data from an ongoing, open-label, non-randomized clinical study in healthcare workers at a single center were provided in a publication (witheld). In this study, 154 individuals 18 years of age and older who had received primary vaccination and a first booster dose with Pfizer-BioNTech COVID-19 Vaccine were administered a second booster dose of Pfizer-BioNTech COVID-19 Vaccine at least four months after the first booster dose. Among these individuals, approximately 11-fold increases in geometric mean neutralizing antibody titers against wild-type virus and Delta and Omicron variants, respectively, were reported at two weeks after the second booster as compared to 5 months after the first booster dose. Pt asked when does the booster become effective and asked if the vaccine he got in November is still working. Pt asked by the 21st of this month will he protected by then and stated his bloodwork was showing he still had antibodies in February/March.  The information on the batch/lot number for BNT162b2 has been requested and will be submitted if and when received.