Legs-Peripheral neuropathy; needle like pain in arms/soreness in my left arm; feeling tingling; tenderness on my skin all over my body, arms legs and scalp; ringing in my ears; difficulty sleeping; feel irritating on my skin; Muscle fatigue; leave work due to the symptoms; flu like symptoms; can"t stand the touch of clothing on my body; This serious case was reported by a consumer and described the occurrence of peripheral neuropathy in a 65-year-old female patient who received Herpes zoster (Shingrix) for prophylaxis.   Concurrent medical conditions included attention deficit hyperactivity disorder. Concomitant products included bupropion.   On 02-SEP-2023, the patient received the 1st dose of Shingrix. On 09-SEP-2023, 7 days after receiving Shingrix, the patient experienced peripheral neuropathy (Verbatim: Legs-Peripheral neuropathy) (serious criteria GSK medically significant) and pain in extremity (Verbatim: needle like pain in arms/soreness in my left arm). In SEP-2023, the patient experienced tingling sensation (Verbatim: feeling tingling), skin tenderness (Verbatim: tenderness on my skin all over my body, arms legs and scalp), ringing in ears (Verbatim: ringing in my ears), difficulty sleeping (Verbatim: difficulty sleeping), skin irritation (Verbatim: feel irritating on my skin), muscle fatigue (Verbatim: Muscle fatigue), inability to work (Verbatim: leave work due to the symptoms), influenza-like symptoms (Verbatim: flu like symptoms) and touch sensitivity increased (Verbatim: can"t stand the touch of clothing on my body).  The outcome of the peripheral neuropathy, pain in extremity, tingling sensation, skin tenderness, ringing in ears, difficulty sleeping, skin irritation, muscle fatigue, inability to work, influenza-like symptoms and touch sensitivity increased were not resolved.   It was unknown if the reporter considered the peripheral neuropathy, pain in extremity, tingling sensation, skin tenderness, ringing in ears, difficulty sleeping, skin irritation, muscle fatigue, inability to work, influenza-like symptoms and touch sensitivity increased to be related to Shingrix.     It was unknown if the company considered the peripheral neuropathy, pain in extremity, tingling sensation, skin tenderness, ringing in ears, difficulty sleeping, skin irritation, muscle fatigue, inability to work, influenza-like symptoms and touch sensitivity increased to be related to Shingrix.   Additional Information: GSK Receipt date: 14-SEP-2023 The Patient was self reported that she had needle like pain in arms and legs peripheral neuropathy. The patient was received bupropion (Start 10 Jul 2020 Stop: Ongoing) for Off lable use for ADHD.  The patient had soreness in her left arm following the injection for one week with slight flu like symptoms. Six days after the Shingrix vaccine, she started feeling tingling and tenderness on my skin all over my body, arms legs and scalp.  She had a slight ringing in her ears and can not stand the touch of clothing on her body and she had difficulty sleeping, even the sheets feel irritating on her skin.  She had muscle fatiuge and had to leave work due to the symptoms and she concerned how long will this last the symptoms. The reporter consent to follow up.