a severe reaction with Pfizer booster; soreness in the left arm; felt lethargic; scleroderma; 1st dose of Moderna COVID-19 Vaccine on 2Feb2021, 2nd dose on 02Mar2021 and Pfizer booster on 29Oct2021; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP and Other HCP). The reporter is the patient. Other Case identifier(s): MOD22-025755 (Moderna).  A female patient received BNT162b2 (BNT162B2), on 29Oct2021 as dose 3 (booster) single (Lot number: 320308D, Expiration Date: Feb2022), in left arm for covid-19 immunisation. The patient's relevant medical history included: "food and other products" (unspecified if ongoing); "chocolate" (unspecified if ongoing); "Acute and Chronic illnesse" (unspecified if ongoing); "asthma" (unspecified if ongoing), notes: since she was a child; "hyperparathyroidism", start date: Apr2021, stop date: Apr2021, notes: she had a surgery to remove the thyroid. Concomitant medication(s) included: OMEPRAZOLE; FLU [INFLUENZA VACCINE], on 15Oct2021 as dose number unknown, single. Past drug history included: Avelox for allergy, reaction(s): "Allergy: Avelox", notes: Allergy: Avelox; Caffeine, reaction(s): "Allergy: caffeine", notes: Allergy: caffeine; Monosodium gluconate for allergy, reaction(s): "Allergy: monosodium gluconate", notes: Allergy: monosodium gluconate. Vaccination history included: moderna (Dose: 1, date: 02Feb2021, Lot number: 004M20A, Route Intramuscular), administration date: 02Feb2021, for COVID-19 immunization, reaction(s): "soreness in left arm", "patient felt lethargic"; BNT162b2 (Dose: 2, date: 02Mar2021, Lot number: 026L20A), administration date: 02Mar2021, for COVID-19 immunization, reaction(s): "her pulse was 90", "she felt so bad", "she felt so hot and her temperature was 102°F", "she had some difficulty breathing but not enough to go to the hospital". The following information was reported: INTERCHANGE OF VACCINE PRODUCTS (medically significant) with onset 29Oct2021, outcome "unknown", described as "1st dose of Moderna COVID-19 Vaccine on 2Feb2021, 2nd dose on 02Mar2021 and Pfizer booster on 29Oct2021"; SCLERODERMA (medically significant) with onset Nov2021, outcome "unknown"; HYPERSENSITIVITY (non-serious), outcome "unknown", described as "a severe reaction with Pfizer booster"; PAIN IN EXTREMITY (non-serious), outcome "unknown", described as "soreness in the left arm"; LETHARGY (non-serious), outcome "unknown", described as "felt lethargic". The event "a severe reaction with pfizer booster" required emergency room visit. Clinical course: Caller stated she did not have history of myocarditis or pericarditis Patient mentioned she had a severe reaction with Pfizer booster and she had to go to urgent care, but with Moderna it was only a slight reaction. For both Moderna vaccines patient did not take any treatment. Patient wanted to know if it would be possible for Safety Team to tell her symptoms that she reported are severe or moderate, for her to take an informed decision about  getting the bivalent booster. patient had not ever COVID + test or diagnosis. Condition 2: Scleroderma(start Date: Nov2021, Recent change in status such as improvement or worsening: no). patient experienced a similar event in the past - it was a food related thing. Concomitant: Vitamins. The patient underwent the following laboratory tests and procedures: Body temperature: 102 Fahrenheit; Heart rate: 90.  No follow-up attempts are possible. No further information is expected.