burn marks on her shoulder where they gave her the shot.; Excruciating/ pain comes on /Mild pain; blisters are busting and scabbing slowly; shake in her arm; arm twitch; burn mark became blisters on right arm; itching; third degree burns on her arm and blisters/burn marks on her shoulder where they gave her the shot. It was on her right arm; third degree burns on her arm and blisters; bruising, burns, and blisters on her arm; burning feeling; Pain in arm; This is a spontaneous report from a Pfizer sponsored marketing program. A contactable consumer(patient) reported that a 41-years-old female patient received bnt162b2 (BNT162B2), dose 1 via an unspecified route of administration, administered in Arm Right on 03May2021 14:00 (Batch/Lot Number: EW0164) as 1ST DOSE, SINGLE for covid-19 immunization, at Age at Time of Vaccination of 41 years old. The patient concomitant medications and medical history was not reported. The patient experienced third degree burns on her arm and blisters/burn marks on her shoulder where they gave her the shot. it was on her right arm on 04May2021, third degree burns on her arm and blisters on 04May2021, bruising, burns, and blisters on her arm on 04May2021, burning feeling on 04May2021, itching on 06May2021, pain in arm on May2021, burn marks on her shoulder where they gave her the shot on an unspecified date, blisters are busting and scabbing slowly on an unspecified date, shake in her arm on an unspecified date, arm twitch on an unspecified date, burn mark became blisters on right arm on an unspecified date, all events with outcome of unknown.  Additional information reported: Caller had her first dose of Pfizer Covid-19 Vaccine on Monday.  On Tuesday, she to go to the Emergency Room. She had third degree burns on her arm and blisters as well. Consumer reporting on self. Caller clarified that her arm looked like third degree burns. She was told her body rejected the vaccine and that was what caused bruising, burns, and blisters on her arm. She awoke Tuesday morning at 0400 experiencing a burning feeling. That woke her up, and she looked in the mirror and saw burn marks on her shoulder where they gave her the shot. It was on her right arm. She did not know what to do.  She applied Vaseline, Neosporin, cold water, it continued to hurt so bad the burning sensation. Cold water soother it up a bit but it was burning so bad. She wrapped it up at 0730, she went to the hospital at 0800, and at 0940, as she was looking at her phone in the waiting room, it was burning real bad. She uncovered the bandages and saw a lot blisters. The Emergency room said her reaction was caused by her body rejecting the vaccine.  It had nothing to do with what she did or what she put on her body. Vaseline (expiry date: unknown; UPC: 305212345001; Product strength and count size dispensed: 13 ounces, unknown strength; LOT number on tube unknown; Available to be returned: N; Package sealed and intact: Y). Neosporin (EXPIRY: Jun2018; Number near the phone number: 30028394; LOT: 2086LZ; Product strength and count size: unknown strength, 0.5 ounce tube; Product available to be returned: N, no packaging ; Product Sealed: Y). Caller added she was taking the thing off her arm, it hurts. Cold wrap was the only thing soothing it. Caller added her arm looked like a big old long burn mark and the burn mark turned into blisters. The blisters are busting and scabbing slowly, but surely.  Caller heard from people it was healing because it was itching real bad.  She has 7 blisters on her arm.  It was not burning, and she was glad for that because it was so excruciating. Now it was itching, it was healing. It was itching really bad, but is still with blisters and it looks nasty. At 0500 this morning it was itching so bad, she though about going back to the Emergency Room.  She does  not want to go back to the Emergency Room and stayed home and tried remedies to stop the pain and itching with cold rags that are soothing it a bit. She was getting a shake in her arm where it was making her arm twitch because it was itching so bad. She was provided antibiotics and Motrin.  When that wears off every 8 hours, the pain comes on and itching get worse. Caller was taking Cleocin. Then clarifies it also states clindamycin hydrochloride, 150 mg, 3 capsules by mouth every 8 hours for 7 days. Product dispensed in two prescription bottles. 63 tablets in first bottle. 12 tablets in second bottle (Expiry: May2022; She reads Microlab: 42571-0251-01 from the bottle; available to send back: N; Received in sealed package: Y). Motrin: take as needed for mild pain every 8 hours (Product strength and count size dispensed: 800 mg tablet by mouth; 15 tablets dispensed; EXPIRY: 4May2022; She reads Timecap: 49483-0604-50 from the bottle; Available to be returned: N; sealed in package: Y). She stayed up until 0400, then at 0500, it was not burning, but itching real bad. She can not scratch it.  Then the pain comes if her medicine wears down.  She uses cold rags in order not to scratch around the area because then it causes pain if she scratches. That is how it wound up busting one of the blisters and she was not paying attention and scratched and it busted the blister and it burns and itches so bad. When she takes Motrin that was when the burning stops. Lot number could be EW0164 or EWO164.  That did not stop, and she did not want to leave the Emergency Room until it stopped.  The Motrin helped out a lot. The event Burns third degree considered medically significant. The events require a visit to Emergency Room. No Prior Vaccinations (within 4 weeks).   Information on Lot/Batch number was available. Additional information has been requested.