SWELLING IN BOTH HANDS; FACE SWELLING; COULD NOT CLOSE HANDS/COULD MAKE A FIST BUT NOT ALL THE WAY; WEIGHT GAIN; IT WAS MADDENING; TIRED; NO ENERGY; HAS NOT BEEN FEELING WELL; This spontaneous report received from a patient concerned a 44 year old female. The patient's weight was 282 pounds, and height was 66 inches. The patient's past medical history included: pituitary adenoma, and concurrent conditions included: penicillin allergy, sulfa allergy, iodine allergy, latex allergy. Patient was a alcohol non user, and non smoker and patient did not have any drug abuse/illicit drug use. The patient received covid-19 vaccine ad26.cov2.s (suspension for injection, route of administration not reported , and batch number: Unknown expiry: Unknown) dose was not reported, 1 total administered to left arm on an unspecified date in APR-2021 for prophylactic vaccination. The batch number was not reported and has been requested. No concomitant medications were reported.  On unspecified date in APR-2021, the patient had not been feeling well since she had taken vaccine. On unspecified date, her both hands and face had swollen up and that this has happened several times and blew it off. Reportedly, the last two times it happened, which was so severe that she had to go to the hospital (date unspecified). She could not close hands, and could make a fist but not all the way. She also stated that her right hand was worse than her left hand with regard to swelling and hands were being like Mickey Mouse hands. The first time she went to the hospital (date unspecified), she was there for 8 days. During this time, she received unspecified diuretics as treatment drug and laid in bed with arms up by her head. On unspecified date she was again hospitalized and the second hospitalization lasted 3 days. No one could figure out what was happening. Her regular physician was blown away and had no idea what was causing this. She went to a rheumatologist on 04-OCT-2021 (day of report) and he did not understand why she was referred to him. Her hands were still swollen at the time of reporting. She was so tired, had no energy and it was so maddening to her. The patient also gained weight. As her normal weight was about 234 pounds, but increased to 282 pounds. She had done nothing to gain this weight and her weight gain also correlates to when she got the vaccine. Hospital admission date and discharge date were unknown.  The action taken with covid-19 vaccine ad26.cov2.s was not applicable. The patient was recovering from could not close hands/could make a fist but not all the way, and had not recovered from has not been feeling well, face swelling, swelling in both hands, tired, weight gain, no energy, and it was maddening. This report was serious (Hospitalization Caused / Prolonged).; Sender's Comments: V0: 20211006303-covid-19 vaccine ad26.cov2.s-swelling in both hands, face swelling, could not close hands/could make a fist but not all the way, weight gain,  it is maddening. This event(s) is considered unassessable. The event(s) has a compatible/suggestive temporal relationship, is unlabeled, and has unknown scientific plausibility. There is no information on any other factors potentially associated with the event(s). 20211006303-covid-19 vaccine ad26.cov2.s-has not been feeling well, tired, no energy. This event(s) is labeled per RSI and is therefore considered potentially related.