MS progression went faster after getting the booster/MS for 35 years now and it has been slow and steadily progressing; Could not even walk; This spontaneous case was reported by a patient and describes the occurrence of MULTIPLE SCLEROSIS (MS progression went faster after getting the booster/MS for 35 years now and it has been slow and steadily progressing) in a female patient of an unknown age who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     Concurrent medical conditions included MS (she had MS for 35 years now).    On an unknown date, the patient received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On an unknown date, the patient experienced MULTIPLE SCLEROSIS (MS progression went faster after getting the booster/MS for 35 years now and it has been slow and steadily progressing) (seriousness criterion medically significant) and GAIT INABILITY (Could not even walk). At the time of the report, MULTIPLE SCLEROSIS (MS progression went faster after getting the booster/MS for 35 years now and it has been slow and steadily progressing) and GAIT INABILITY (Could not even walk) outcome was unknown.            No concomitant medication provided. No treatment medication information provided. The patient stated that she had MS for 35 years now and it had been slow and steadily progressing. However, after getting the 1st booster dose of the Moderna Covid-19 vaccine, it set off to a different path and the progress went faster downhill. The patient also stated that she could not even walk  and was graciously thankful for what Moderna was doing but the patient would like to ask if there was any vaccine in the making that was tailor made for patients with autoimmune disorder so that they will not have the same reaction as what the patient was having.  The patient was all about protecting herself against Covid-19 as well as other people around her  but that patient stated that the body reacted to the vaccine differently. It might had protected from Covid-19 but it made MS progressed fast.  Company comment: This spontaneous case concerns a female patient (age unspecified) with relevant medical history of Multiple sclerosis, who experienced the unexpected serious (medically significant) AESI of Multiple sclerosis (progression of multiple sclerosis), on an unspecified date after receiving the 3rd dose of mRNA-1273 vaccine (booster). It was reported that the Moderna boosted dose accelerated the progression of Multiple sclerosis. The outcome was reported as unknown. Details of concomitant medications, investigation reports, and treatment were not provided. Medical history of Multiple sclerosis remains a confounder. Details of first two doses of vaccine were not provided. The benefit-risk relationship of the mRNA-1273 vaccine is not affected by this report.   This case was linked to MOD-2022-526760 (Patient Link).; Sender's Comments: This spontaneous case concerns a female patient (age unspecified) with relevant medical history of Multiple sclerosis, who experienced the unexpected serious (medically significant) AESI of Multiple sclerosis (progression of multiple sclerosis), on an unspecified date after receiving the 3rd dose of mRNA-1273 vaccine (booster). It was reported that the Moderna boosted dose accelerated the progression of Multiple sclerosis. The outcome was reported as unknown. Details of concomitant medications, investigation reports, and treatment were not provided. Medical history of Multiple sclerosis remains a confounder. Details of first two doses of vaccine were not provided. The benefit-risk relationship of the mRNA-1273 vaccine is not affected by this report.