lyme's disease; parkinsonian syndrome; tremors predominantly on the right side; mental fog; inability to stand up straight; slowness in moving; inability to move; sometimes unable to speak; slugishness; tiredness; swaying; Initial information received on 12-Jan-2022 regarding an unsolicited valid  serious case received from a patient.  This case involves a 36 years old male patient who experienced lyme's disease, parkinsonian syndrome, tremors predominantly on the right side, mental fog, inability to stand up straight, slowness in moving, inability to move, sometimes unable to speak, slugishness, tiredness and swaying while receiving vaccine diphtheria-2/tetanus/5 ac pertussis vaccine [Adacel].  The patient's past medical history, medical treatment(s), vaccination(s), concomitant medication, and family history were not provided.  On 28-Jun-2016, the patient received a dose of suspect 0.25 mL to 2 mL for vaccines or 0.1 mL for TB skin test of diphtheria-2/tetanus/5 ac pertussis vaccine once (lot C4689AA, expiry date: 16-Jan-2017) via intramuscular route in the left deltoid as prophylactic vaccination.  On an unknown date the patient had lyme's disease (lyme disease) (unknown latency). This event was assessed as medically significant.  On 28-Jun-2016 the patient had parkinsonian syndrome (parkinsonism), tremors predominantly on the right side (tremor), mental fog (confusional state), inability to stand up straight (dysstasia), slowness in moving (bradykinesia), inability to move (movement disorder), sometimes unable to speak (speech disorder), slugishness (sluggishness), tiredness (fatigue), swaying (dizziness). Latency: same day for all these events.  The patient stated it was the vaccine that caused the damage because that's what happened right before he got sick. He wasn't going to get the vaccination, he was shown a video by his wife that their our daughter could die. In hindsight, he don't even know anyone who suffered from whooping cough. Caller stated his doctors initially treated him for Lyme's for a year and a half; states there was a, laundry list of stuff they put him on for Lyme's." Caller stated they then put him on Parkinson's medicine, specifically Carbidopa-Levodopa. Caller stated at one point he was taking so many pharmaceuticals, states he was now starting to take more "natural supplements; states he was struggling to find the correct dosing for these natural supplements  Relevant laboratory test results included: Scan - On an unknown date:  [Parkinsonian Syndrome was diagnosed by doing a nuclear medical scan in a neurological setting]   Action taken: was not applicable.  Corrective treatment: Carbidopa + Levodopa was used as corrective treatment for Parkinsonian Syndrome and unknown for the other events.  Outcome: Not recovered; Sender's Comments: Sanofi Company Comment dated 17-Jan-2022. This case involves a 36 years old male patient who experienced lyme's disease while receiving Adacel. The causal role of the company suspect vaccine cannot be assessed based on the temporal relevance. Further information regarding time to onset, concurrent condition during vaccination, previous vaccination, tolerance, allergic history, laboratory investigations excluding alternative etiologies for the reported event are needed to fully assess this case. Based upon the reported information, the role of the individual suspect vaccine cannot be assessed