STROKE; This spontaneous report received from a consumer concerned a 56 year old male with unknown race and ethnicity. The patient's height, and weight were not reported. The patient's past medical history included: gall bladder removed recently (June 2021) due to upper Gastrointestinal (GI) issues, and concurrent conditions included: diabetic, blind, hyperlipidemia, and high blood pressure. The patient experienced drug intolerance and makes sick when treated with hydrocodone.  The patient received covid-19 vaccine (suspension for injection, route of admin not reported, and batch number: 202A21A expiry: unknown) dose was not reported, 1 total, administered on 16-AUG-2021 to left arm for prophylactic vaccination. No concomitant medications were reported.  On 20-AUG-2021 Friday, the patient was fine after receiving the vaccine, he even mowed the yard. On 21-AUG-2021 Saturday, at the morning patient woke up and could barely get out of bed and could not walk due to his feet being numb, then reported his hands were numb.  On 23-AUG-2021 Monday, patient went to the hospital and received fluids and other care, and was discharged. On 24-AUG-2021, patient went to his health care provider (HCP), who sent him to the hospital via ambulance to be admitted through the emergency room (ER) for possible stroke, although reporter stated they doubted that diagnosis due to both sides of the body being affected. On 24-AUG-2021, the patient was admitted to the hospital and has had a spinal tap, Computer tomography (CT) scans, Magnetic resonance imaging (MRI), and other tests. As per the reporter patient were treated it as Guillain Barre Syndrome(GBS). The reporter was upset the vaccine facility gave the sheets with possible side effects to them after having received the vaccine. On 29-AUG-2021, reporter reported that patient was still in the hospital and that the physicians state they was treating it as Guillain Barre Syndrome and/or a stroke. The reporter stated that, patient was treated with shots in the stomach as well as intravenous (IV) medications possibly Immunoglobulins but reporter does not exactly know the names as currently the hospital was not allowing any visitors and so only form of communication with patient through phone. The reporter called back to update the diagnosis, which she stated hospital found high protein in the spinal fluid which could be markers for stroke. As per the reporter physician called it an unusual stroke being that it was close to the brain stem. The reporter repeated that she did not like the fact that the vaccine administrators provided the information about the vaccine after the shot was given and that not that it would have changed our minds at that moment but still maybe something that they could do to improve the vaccination process.  The action taken with covid-19 vaccine was not applicable. The patient had not recovered from stroke.  This report was serious (Hospitalization Caused / Prolonged).; Sender's Comments: V0: 20210858451-COVID-19 VACCINE AD26.COV2.S-Stroke. This event is considered unassessable. The event has a compatible/suggestive temporal relationship, is unlabeled, and has unknown scientific plausibility. There is no information on any other factors potentially associated with the event.