my doctor immediately said you know we want to rule out a blood clot so blood was drawn to the lab; Right ankle was swollen; There is some problem down with the leg not as bad I say but having the same pain I feel a sensation in my feet when I stand; This is a spontaneous report from a contactable consumer (patient). An 81-year-old patient of an unspecified gender received BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE, solution for injection) (at 81 years of age), via an unspecified route of administration on 22Mar2021 (Batch/Lot Number: EN6206) as 2ND DOSE, SINGLE for COVID-19 immunisation; amlodipine besilate (manufacturer unknown), via an unspecified route of administration from an unspecified date (Batch/Lot number was not reported) to an unspecified date, at 10 mg, 1x/day for blood pressure management and valsartan via an unspecified route of administration from an unspecified date (Batch/Lot number was not reported) to an unspecified date, at 80 mg, 1x/day at bed time (anywhere between 9 and 10:15 PM) as blood pressure medication. Medical history included glaucoma and hypertension (Blood pressure) from an unknown date and unknown if ongoing; additional medical condition reported as felt at times like he/she want to itch ('felt itching but never scratch myself or anything like that'). Concomitant medication included bimatoprost (LUMIGAN) taken for glaucoma, start and stop date were not reported. Historical vaccine included BNT162B2 dose 1 on 01Mar2021 (at 81 years of age) for COVID-19 immunisation. The patient took the two treatments of the Pfizer vaccine. The patient had a problem from the second vaccination administered on 22Mar2021 with the LOT# EN6206. The patient took the last treatment on 22Mar2021 at the health department, which was the one that had created problems for him/her. The patient mentioned that there was no problem at all with the first treatment. The patient stated that first of all, he/she was on the blood pressure medications and one of the medications was valsartan 80 mg and the other one was amlodipine 10 mg, once a day; the patient take valsartan at bed time (anywhere between 9 and 10:15 [something like] that PM). The patient was taking amlodipine 10 mg for blood pressure, and then from reading what he/she got from the pharmacist on the valsartan, it was supposed to work by relaxing blood vessel so the blood can flow more easily lowering high blood pressure to help prevent stroke, heart attack and kidney problems; so the patient had been taking those two. It was reported that after the patient took the second Pfizer vaccine on 22Mar2021,  in the evening he/she noticed that his/her right ankle was swollen not in the morning but in the evening say by anywhere from 6 to 7 PM to 8:00 PM, it was swollen occasionally and then it looked like there was some problem down with the leg not as bad he/she said but having the same pain he/she felt a sensation in the feet when he/she stands. So the patient saw his/her doctor, had an appointment with him on 20Apr2021 and at the time of the appointment which was at 2:45 in the afternoon, there was no swelling; the patient did tell him that he/she had this reaction and it started the same day he/she got the treatment but it was in the evening that she/he noticed it, not in the morning, not the afternoon but the evening, late evening. The patient did not take any treatment for these adverse events which the doctor immediately said that they want to rule out a blood clot, so blood was drawn to the lab. The patient saw the doctor on the 20th about a week later and called his office and was told report had not come in and the patient had not heard from his office since that time. The patient was making assumption right or wrong that had there been a blood clot, the office would have called him/her okay. But the doctor said that he wanted to rule that out then he said they might have need to lower the dosage of amlodipine, those were the things he remembered him saying so. But the patient's concern was not it was because the ankle does swell and then when he/she went to bed and lie down of course it stopped it did not swell, when he/she got up in the morning it was normal ankle so but the patient did not know what was going on and did  not know if this was the reaction that no one else had; he/she was not sure what to do about it at this point. The patient wondered if the symptoms were direct result of his/her mixed medications that he/she had taken with the Pfizer vaccine and commented that he/she certainly had no problem with the first. The patient added concern whether there was a causal relation between the medication he/she was taking and that second vaccine, he/she does not know what. The patient's main concern was to get his/her ankle un-swollen which what happened since the last dose, no problem with the first dose but the last dose that was where it was. The patient did not know what the diagnosis that was causing the problem as he/she said the doctor had taken the had blood drawn to send to the lab to rule out the blood clot. The patient underwent lab tests and procedures which included blood test: unknown results on an unspecified date. The action taken in response to the events for amlodipine besilate and valsartan was unknown. The outcome of the events was unknown.  Pfizer is a marketing authorization holder of Amlodipine Besilate in the country of incidence or the country where the product was purchased (if different). This may be a duplicate report if another marketing authorization holder of Amlodipine Besilate has submitted the same report to the regulatory authorities.  No follow-up attempts are needed. No further information is expected.