stroke event as the result of the vaccine; inability to function on a day to day basis; confusion; moderate-severe memory loss; fatigue; severe headaches; This spontaneous case was reported by a consumer (subsequently medically confirmed) and describes the occurrence of CEREBROVASCULAR ACCIDENT (stroke event as the result of the vaccine), LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (inability to function on a day to day basis), CONFUSIONAL STATE (confusion), AMNESIA (moderate-severe memory loss), FATIGUE (fatigue) and HEADACHE (severe headaches) in a 33-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination.     No Medical History information was reported.    In May 2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 08-Jun-2021, the patient experienced CEREBROVASCULAR ACCIDENT (stroke event as the result of the vaccine) (seriousness criteria hospitalization, disability, medically significant and life threatening), LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (inability to function on a day to day basis) (seriousness criteria hospitalization, disability and life threatening), CONFUSIONAL STATE (confusion) (seriousness criteria hospitalization and medically significant), AMNESIA (moderate-severe memory loss) (seriousness criteria hospitalization and medically significant), FATIGUE (fatigue) (seriousness criteria hospitalization and medically significant) and HEADACHE (severe headaches) (seriousness criteria hospitalization and medically significant). The patient was treated with SALINE [SODIUM CHLORIDE] for Adverse event, at an unspecified dose and frequency. At the time of the report, CEREBROVASCULAR ACCIDENT (stroke event as the result of the vaccine), LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (inability to function on a day to day basis), CONFUSIONAL STATE (confusion), AMNESIA (moderate-severe memory loss), FATIGUE (fatigue) and HEADACHE (severe headaches) outcome was unknown.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On 17-Aug-2021, Magnetic resonance imaging: normal (normal) No cerebral Spinal Fluid found in the brain.     mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) was withdrawn on an unknown date.       No concomitant medications were reported.  On 8Jun2021, his wife was admitted to the ER at the Memorial Hospital due to a stroke event as the result of the vaccine. She was given saline and started to feel better. She has gone to the doctors multiple times. Since then, she has had issues. She has moderate-severe memory loss, she had a MRI done 17Aug2021 and they did not find any cerebral spinal fluid in the brain. She had fatigue, severe headaches, confusion, inability to function on a day to day basis. She met with the neurologist 31Aug2021 and had an appointment with her PCP 02 Sep 2021 to get the stuff set up for additional doctor appointments. She will be seeing another neurologist on 5 Oct 2021.  Company Comment: This case concerns a 33 year old female  with no medical history who experienced CVA approximately a month after the first does of the Moderna Covid 19 vaccine. Dechallenge was unknown and Rechallenge was not applicable. The benefit-risk relationship is not affected by this report.; Sender's Comments: This case concerns a 33 year old female  with no medical history who experienced CVA approximately a month after the first does of the Moderna Covid 19 vaccine. Dechallenge was unknown and Rechallenge was not applicable. The benefit-risk relationship is not affected by this report.