aches; feeling crappy; runny nose; coughing; wheezing; fatigue; thinks it is Hemolytic Anemia/believes it is an auto immune anemia; severe bronchospasm attack; This spontaneous case was reported by a physician and describes the occurrence of HAEMOLYTIC ANAEMIA (thinks it is Hemolytic Anemia/believes it is an auto immune anemia), PAIN (aches), IRRITABILITY (feeling crappy), RHINORRHOEA (runny nose), COUGH (coughing), WHEEZING (wheezing), BRONCHOSPASM (severe bronchospasm attack) and FATIGUE (fatigue) in a 35-year-old female patient who received mRNA-1273.815 (SPIKEVAX 2023-2024) (batch no. ASKU) for COVID-19 prophylaxis.     Previously administered products included for Product used for unknown indication: Flu vaccine and estrogen. Past adverse reactions to the above products included No adverse event with Flu vaccine and estrogen. Concomitant products included BROMHEXINE HYDROCHLORIDE, GUAIFENESIN, SALBUTAMOL (PROVENTIL PLUS) for Bronchospasm, TRIAMCINOLONE DIACETATE (PROCTOSTEROID) and PREDNISONE for an unknown indication.    In October 2023, the patient received dose of mRNA-1273.815 (SPIKEVAX 2023-2024) (unknown route) 1 dosage form. In 2023, the patient experienced HAEMOLYTIC ANAEMIA (thinks it is Hemolytic Anemia/believes it is an auto immune anemia) (seriousness criteria hospitalization and medically significant) and BRONCHOSPASM (severe bronchospasm attack) (seriousness criterion hospitalization). In October 2023, the patient experienced PAIN (aches) (seriousness criterion hospitalization), IRRITABILITY (feeling crappy) (seriousness criterion hospitalization), RHINORRHOEA (runny nose) (seriousness criterion hospitalization), COUGH (coughing) (seriousness criterion hospitalization), WHEEZING (wheezing) (seriousness criterion hospitalization) and FATIGUE (fatigue) (seriousness criterion hospitalization). At the time of the report, HAEMOLYTIC ANAEMIA (thinks it is Hemolytic Anemia/believes it is an auto immune anemia), PAIN (aches), IRRITABILITY (feeling crappy), RHINORRHOEA (runny nose), COUGH (coughing), WHEEZING (wheezing), BRONCHOSPASM (severe bronchospasm attack) and FATIGUE (fatigue) had not resolved.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): In 2023, Full blood count: hemoglobin 7 and hemoglobin was 10.     For mRNA-1273.815 (SPIKEVAX 2023-2024) (Unknown), the reporter did not provide any causality assessments.   Patient received Spikevax about 2-3 week ago and soon after developed fatigue aches, feeling crappy, right after, upper respiratory symptoms, runny nose, coughing, wheezing about a week after that she developed bronchospasm attack. The frightening thing is that she eventually had a severe bronchospastic attack that she was given inhalation therapy, Proventil. The patient was prescribed inhaled steroid. Week after getting the vaccine, the patient had CBC drawn and her hemoglobin came back as 7 and it was repeated 5 days later, 2 hours prior to repeating CBC, the patient received Prednisone 20mg taken orally and hemoglobin was 10. HCP states that it appears to be an auto immune anemia. The patient has never been hospitalized.   HCP stated that last night 06Nov2023, the patient had second severe bronchospastic attack . HCP states that it appears that he thinks it is Hemolytic Anemia. Patient requires immediate steriod treatment. HCP states that this occurred closely after receiving the vaccine, and believes it is an auto immune anemia. He has searched for journals and studies and not able to find much information. HCP didn't have lot numbers to current nor previous Moderna vaccines.   Treatment information was not reported.  Company Comment; This is a Spontaneous case reported by a physician, concerning a 35-year-old transgendered female patient, with no relevant medical history, who experienced the unexpected and serious (due to hospitalization and medically significant) event of Haemolytic anaemia, and the unexpected and serious (due to hospitalization) events of Pain, Irritability, Rhinorrhoea, Cough, Wheezing, Bronchospasm and Fatigue, which occurred after an unspecified dose of SPIKEVAX 2023-2024 vaccine. As reported, soon after vaccination the patient developed fatigue aches and feeling crappy. Right after, she experienced upper respiratory symptoms, runny nose, coughing and wheezing. 1 week after that, she developed bronchospasm attack. Patient was treated with inhalation therapy, salbutamol. She was also prescribed inhaled steroid. 1 week after vaccination, the patient had complete blood count drawn and her hemoglobin came back as 7. HCP stated that it appears to be a hemolytic anemia. Patient required immediate steroid treatment. At the time of the report, the events had not resolved. The benefit-risk relationship of SPIKEVAX 2023-2024 vaccine is not affected by this report.