autoimmune conditions are "going crazy"/ "several autoimmune things that are going bizarre"; chills; flare up of her multiple sclerosis (MS); allergies started acting up; congested and her nose was running like crazy; congested and her nose was running like crazy; fatigue any how; mild headache; fever; arthritis started to act up; hands ache; cramps in legs again; diarrhea; This is a spontaneous report from a contactable consumer. A 77-years-old female patient received bnt162b2 (PFIZER-BIONTECH COVID-19 VACCINE), dose 3 via an unspecified route of administration at age of 77-years-old on 27Sep2021 (Lot Number: FC3184) as DOSE 3 (BOOSTER), SINGLE for covid-19 immunisation; interferon beta-1b (BETASERON), via an unspecified route of administration from an unspecified date (Lot Number: KT09F66; Expiration Date: Nov2022) at 3 mg, alternate day for an unspecified indication. Medical history included eczema, multiple sclerosis, blood pressure, shrunk a little. Concomitant medication(s) included gabapentin taken for multiple sclerosis from 2000 and ongoing; baclofen taken for multiple sclerosis from 2000 and ongoing; bisoprolol fumarate taken for an unspecified indication from an unspecified start date and ongoing; clopidogrel taken for an unspecified indication from an unspecified start date and ongoing; amlodipine taken for blood pressure, start and stop date were not reported; simvastatin taken for an unspecified indication, start and stop date were not reported. The patient previously received first dose of bnt162b2 for covid-19 immunisation at age of 77-years-old on 30Jan2021 (lot number: EN5318) for Covid-19 immunization, second dose of bnt162b2 (lot number: EL9266) at age of 77-years-old on 19Feb2021 for covid-19 immunisation and experienced down for a week, COPAXONE and experienced got red and itchy and, and took Avonex. The patient experienced flare up of her multiple sclerosis (MS) on 27Sep2021, autoimmune conditions are "going crazy"/ "several autoimmune things that are going bizarre" on an unspecified date, allergies started acting up in Sep2021, congested and her nose was running like crazy in Sep2021, fatigue any how in Sep2021, mild headache in Sep2021, fever in Sep2021, arthritis started to act up, hands ache, cramps in legs again in Sep2021, diarrhea in Sep2021, chills on an unspecified date. Clinical course reported as: The MS flare up started the night she got the booster. It started with mild headache. By the next morning she had a good headache and fever. She looked like character because her cheeks were nice and red. Then arthritis started to act up. Her hands ache. She has cramps in legs again. All kinds of fun things. She had chills. Then she had diarrhea. The allergies started acting up and she got congested and her nose was running like crazy. With her MS symptoms she has fatigue anyhow, but there were 2 days she didn't get out of bed at all. She slept around the clock pretty much. She explained prednisone was the only thing that currently alleviates her symptoms. She mentioned she continued to take her allergy shot every two weeks and her MS treatment, Betaferon, every other day. The doctor put her on a Prednisone pack and it seemed to be working and helping with flare up. It started with 6 pills and then the next day she had to take 5 pills. The patient underwent lab tests and procedures which included body height: shrunk a little prior to vaccines. The action taken in response to the event(s) for interferon beta-1b was dose not changed. Outcome of flare up of her multiple sclerosis (MS) was not recovered, other events was unknown.