Asthma is getting worse/ gasping/ short of breath; This is a spontaneous report received from two contactable consumers (one of them was the patient and the other was the patient's wife). A 63-year-old male patient received BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE, lot number EN6203), intramuscular in left arm on 09Mar2021 15:00 (at the age of 63-year-old) as 1st dose, single for COVID-19 immunization. Vaccine was not administered at military facility. The patient's medical history included diabetes from two years before the present report (2019), weakness in legs from three and half years before the present report (2017) and asthma from 2005 and ongoing (patient mentioned he had been sick with asthma for 16 years (2005), it was work related). No family history was provided. The patient's concomitant medications included prednisone 10 mg, oral from unspecified date in 2005 at 20 mg and ongoing, daily (reported as two daily), benralizumab (FASENRA, lot number mm0071 and expiration date Mar2022) 30 mg/ml injection, parenteral from unspecified date at 30 mg cyclic (reported as one ml by injection once every two months), both for asthma. No prior vaccinations within 4 weeks as well as no additional vaccines on same date of the Pfizer vaccine were administered. Patient stated that the literature stated not to take any other injections of any kind. He was on FASENRA for his severe asthma. It is a blocker of eosinophils. He was due to have it once every 2 months, but it was on the same time as the Pfizer shot so he didn't take it. His asthma was getting worse. He was gasping and short of breath. He had been on prednisone for 16 years from the time of this report (2005). He was on 20 mg he could boost to 35 mg so he could deal with his asthma (and not get the FASENRA shot). He was 15 days overdue for his FASENRA shot. He needed to wait 3 weeks after his first dose to get the 2nd dose and wait more week to get his FASENRA shot. Patient asked if he could get up on prednisone and why it did state not to take any injections during and after the vaccine. At this point the vaccine was more important. He also asked what the reason was and if it was stressing on the injections. That was his main conflict. Patient also asked if having not had side effects did it mean that the vaccine had not work. As per response provided it was stated that there was no information in the Pfizer-BioNtech COVID-19 vaccine prescribing information about a potential interaction or administration with FASENRA. Patient read not to take any injections because it might interfere with the vaccine. However, every two months he gets a FASENRA injection for severe asthma. He had it in his refrigerator for someone to administer to him at his house because he was afraid to go to the doctor or the hospital because of COVID. Reported his asthma started getting worse last week (Mar2021), he was unsure what day. He added he was on prednisone 20 mg and was still gasping for breath when he had to go up stairs. He added they also said there was concern about prednisone. He stated he might be able to stabilize if he went up on the prednisone. He added he was supposed to take his FASENRA injection about the same time as the vaccine and at the time of this report he was overdue for the injection. He added maybe he should just take it in a different arm. He was scheduled to receive the next dose of the vaccine on 30Mar2021. He added the FASENRA blocks eosinophils and he thought not having the FASENRA was contributing to his problem. He was asking what the prednisone did in relation to the vaccine because they asked him to wait longer and if he could take his FASENRA injection. He also asked if there were any medications he was not supposed to take with the vaccine. The event did not require emergency room or physician office visit. The outcome of the event was not resolved.  No follow-up attempts are needed. No further information is expected.