I tested positive for Covid-19 on May 9th and began taking a 5-day course of Paxlovid; This spontaneous case was reported by a patient and describes the occurrence of COVID-19 (I tested positive for Covid-19 on May 9th and began taking a 5-day course of Paxlovid) in a 46-year-old male patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination.     Concurrent medical conditions included Asthma, Dust allergy, Allergy to animal dander (pet), Pollen allergy, Smoke sensitivity and Penicillin allergy.   On 18-Dec-2021, the patient received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On an unknown date, the patient received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On an unknown date, received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 09-May-2022, the patient experienced COVID-19 (I tested positive for Covid-19 on May 9th and began taking a 5-day course of Paxlovid). The patient was treated with NIRMATRELVIR, RITONAVIR (PAXLOVID) from 09-May-2022 to 13-May-2022 for COVID-19, at a dose of 12-hour intervals. At the time of the report, COVID-19 (I tested positive for Covid-19 on May 9th and began taking a 5-day course of Paxlovid) was resolving.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On 09-May-2022, SARS-CoV-2 test: positive (Positive) Positive. In May 2022, Body temperature: 102 degrees (High) 102 degrees. On 17-May-2022, SARS-CoV-2 test: negative (Negative) negative. On 19-May-2022, SARS-CoV-2 test: positive (Positive) Positive. On 24-May-2022, SARS-CoV-2 test: negative (Negative) Negative.         The patient was not taking any other medications or products within 2 weeks of starting COVID-19 treatment.   The patient began taking a 5 day course of Paxlovid, prescribed to health and hospitals emergency COVID telehealth appointment. His symptoms were relatively mild, fever and chills for the first 36hrs, sore throat, cough. He improved after a few days, and eventually tested negative for COVID and was feeling pretty ok by then. Two days later he developed a sore throat and cough again and tested positive for COVID. For the next several days he got much sicker than the first time, high fever of 102 degrees for several days, far worse cough, terrible headaches, much more fatigue. He eventually recovered and tested negative for COVID. It seemed he had the classic Paxlovid rebound. He had the full course of Paxlovid at the correct. Still, he had some fatigue and lingering cough but mostly better.  Company comment- This spontaneous case concerns a 46-year-old male patient with no reported medical history, who experienced unexpected, non-serious adverse event of special interest Covid-19 (with positive Sars-CoV test) 4 months and 3 weeks after vaccination with a third dose of mRNA-1273. After testing positive for Covid-19, the patient began taking a 5-day course of Paxlovid. His symptoms were relatively mild with fever, chills, sore throat and cough which improved after a few days. He eventually tested negative for Covid 8 days after. Two days later, the patient developed sore throat, cough and tested positive for Covid again. The patient complained he got much sicker than the first time with high fever, worse cough, headache and fatigue. The patient recovered and tested negative for Covid 5 days after. The outcome of the events was reported as resolving. The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report.; Sender's Comments: This spontaneous case concerns a 46-year-old male patient with no reported medical history, who experienced unexpected, non-serious adverse event of special interest Covid-19 (with positive Sars-CoV test) 4 months and 3 weeks after vaccination with a third dose of mRNA-1273. After testing positive for Covid-19, the patient began taking a 5-day course of Paxlovid. His symptoms were relatively mild with fever, chills, sore throat and cough which improved after a few days. He eventually tested negative for Covid 8 days after. Two days later, the patient developed sore throat, cough and tested positive for Covid again. The patient complained he got much sicker than the first time with high fever, worse cough, headache and fatigue. The patient recovered and tested negative for Covid 5 days after. The outcome of the events was reported as resolving. The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report.