immunology system has been compromised; hepatitis C antibody test reactive, nucleic acid test is nonreactive; This is a spontaneous report received from contactable reporter (Consumer or other non HCP). The reporter is the patient.  A 65-year-old female patient received BNT162b2, BNT162b2 omi ba.4-5 (BNT162B2, BNT162B2 OMI BA.4-5), on 25Nov2022 as dose 5 (booster), single (Lot number: GJ6796) at the age of 65 years, in left arm for COVID-19 immunisation. The patient had no relevant medical history. The patient's concomitant medications were not reported. Vaccination history included: BNT162b2 (1st dose, NDC number, lot number, expiration date: thinks it is EM6204., Anatomical location: Given in top of left arm caller is pretty sure), administration date: 10Mar2021, when the patient was 63-year-old, for Covid-19 immunization; BNT162b2 (2nd dose:, NDC number, lot number, expiration date: Thinks ER8737., Dose amount, route, time received: Unknown, not on vaccination card., Anatomical location: Given in top of left arm caller is pretty sure.), administration date: 31Mar2021, when the patient was 63-year-old, for Covid-19 immunization; BNT162b2 (3rd dose:, NDC number, lot number, expiration date: FE3590, Dose amount, route, time received: Unknown, not on vaccination card., Anatomical location: Given in top of left arm caller is pretty sure.), administration date: 22Oct2021, when the patient was 64-year-old, for Covid-19 immunization, reactions: "Hepatitis C antibody test reactive", "immunology system has been compromised "; BNT162b2 (4th dose:, NDC number, lot number, expiration date: FM7553, Dose amount, route, time received: Unknown, not on vaccination card., Anatomical location: Given in top of left arm caller is pretty sure.), administration date: 10Jun2022, when the patient was 64-year-old, for Covid-19 immunization; fluzone high dose quad (Sanofi-Pasteur, Lot number: UJ919AB, Expiration date: 30Jun2023, NDC number: Unknown), administration date: 12Oct2022, when the patient was 65-year-old, for immunization; prevnar 20 (Manufacturer: Wyeth/Pfizer, Lot number: FJ2603, Expiration date: 30Jun2023, NDC number: Unknown, not on the CVS papers., Dose amount, route: 0.5ml), administration date: 21Oct2022, when the patient was 65-year-old, for immunization; flu (got the yearly flu vaccine, specific name, manufacturer, lot number, NDC number, expiration date: Unknown at time of call.), administration date: 05Nov2021, when the patient was 64-year-old, for immunization; Flu (specific name, manufacturer, lot number, NDC number, expiration date: Unknown at time of call. Confirmed prior to getting the Pfizer COVID vaccine.), administration date: 2020, for immunization. The following information was reported: HEPATITIS C ANTIBODY POSITIVE (non-serious) with onset Jan2023, outcome "unknown", described as "hepatitis C antibody test reactive, nucleic acid test is nonreactive"; IMMUNE SYSTEM DISORDER (non-serious), outcome "unknown", described as "immunology system has been compromised". The events "hepatitis c antibody test reactive, nucleic acid test is nonreactive" and "immunology system has been compromised" required physician office visit. Relevant laboratory tests and procedures are available in the appropriate section. Additional information: The patient has given blood over the past 5 or 6 years about 12 times and just recently went to see physician because caller got rejected in Mar2022 and again in Jan2023 for the hepatitis C antibody test being reactive, but when the nucleic acid test was done, the nucleic acid test is nonreactive. The blood donors do the hep C virus antibody HCV which came back reactive so then did the more rigorous test, the nucleic acid testing HCV NAT, and that test came back nonreactive. Doctor thinks that caller's immunology system has been compromised due to the vaccine because doctor has been testing caller for the last 4 years and the hep C nucleic acid test has been nonreactive. Only thing different in caller's life is the fact that caller got the COVID vaccine and the 3 boosters. The patient can't give blood now for 6 months, then will have to get blood tested and pass certain tests.; Sender's Comments: Linked Report(s) : US-PFIZER INC-202300077790 Same patient/event/drug; different suspect dose;