On Apr-2022, five months after booster, she started having swelling in the left leg, progressing to the left arm and left side of body; On Apr-2022, five months after booster, she started having swelling in the left leg, progressing to the left arm. The left arm swelling is gone down. Now the right arm is swollen; Left ankle is still swollen.; This spontaneous case was reported by a physician and describes the occurrence of GENERALISED OEDEMA (On Apr-2022, five months after booster, she started having swelling in the left leg, progressing to the left arm and left side of body), PERIPHERAL SWELLING (On Apr-2022, five months after booster, she started having swelling in the left leg, progressing to the left arm. The left arm swelling is gone down. Now the right arm is swollen) and JOINT SWELLING (Left ankle is still swollen.) in a 63-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 033F21A, 024H20A or 024A20A and 026L20A) for COVID-19 vaccination.     Previously administered products included for Product used for unknown indication: Shingrix shot (Shingrix shot no. 1) on 25-Feb-2021 and Shingrix shot (Shingrix shot no. 2) on 24-Sep-2021. Past adverse reactions to the above products included No adverse event with Shingrix shot and Shingrix shot.   On 15-Jan-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 12-Feb-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 05-Nov-2021, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. In April 2022, the patient experienced GENERALISED OEDEMA (On Apr-2022, five months after booster, she started having swelling in the left leg, progressing to the left arm and left side of body), PERIPHERAL SWELLING (On Apr-2022, five months after booster, she started having swelling in the left leg, progressing to the left arm. The left arm swelling is gone down. Now the right arm is swollen) and JOINT SWELLING (Left ankle is still swollen.). At the time of the report, GENERALISED OEDEMA (On Apr-2022, five months after booster, she started having swelling in the left leg, progressing to the left arm and left side of body), PERIPHERAL SWELLING (On Apr-2022, five months after booster, she started having swelling in the left leg, progressing to the left arm. The left arm swelling is gone down. Now the right arm is swollen) and JOINT SWELLING (Left ankle is still swollen.) had not resolved.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On an unknown date, Computerised tomogram: normal (normal) Normal.     For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown), the reporter did not provide any causality assessments.   No Concomitant product use was reported.  The reporter reported that on APR2022, five months after booster, the patient started having swelling in the left leg, progressing to the left arm and left side of body. The left arm swelling has gone down. Now the right arm was swollen. Left ankle was still swollen. The patient had seen their primary doctor.   It was also reported that the CT scan and Tests were appeared normal. The patient was scheduled to see a Rheumatologist soon.  No treatment information was provided.