Menstrual cycle stopped/ Cycle is still abnormal 3 months later; Tiredness and fatigue; Dark blood spotting, no actual period; This is a spontaneous report received from a contactable reporter(s) (Other HCP). The reporter is the patient.  A 41 year-old female patient received bnt162b2 (BNT162B2), intramuscular, administered in arm, administration date 15Jul2021 (Lot number: EW0183) as dose 1, single for covid-19 immunisation. Relevant medical history included: "Medication: allergy" (unspecified if ongoing); "Environmental: Allergy" (unspecified if ongoing); "PCN" (unspecified if ongoing); "Seasonal allergies" (unspecified if ongoing). Concomitant medication(s) included: ZOLOFT taken for anxiety, start date: 2002 (ongoing); ZYRTEC [CETIRIZINE HYDROCHLORIDE] taken for hypersensitivity, start date: 2018 (ongoing). The following information was reported: FATIGUE (non-serious) with onset 15Jul2021, outcome "recovered" (21Aug2021), described as "Tiredness and fatigue"; MENSTRUAL DISORDER (non-serious) with onset 24Jul2021, outcome "recovering", described as "Menstrual cycle stopped/ Cycle is still abnormal 3 months later"; INTERMENSTRUAL BLEEDING (non-serious) with onset 2021, outcome "not recovered", described as "Dark blood spotting, no actual period". Therapeutic measures were not taken as a result of fatigue, menstrual disorder.  Additional information: All the signs and symptoms of the anaphylactic reaction described as 1st vaccine 15Jul2021, caused tiredness and fatigue. Menstrual cycle stopped. 2nd vaccine 19Aug2021 caused excessive tiredness fatigue all over body itching without rash or redness. Still no menstrual cycle. 1st vaccine, tiredness/fatigue within hours, subsided by second day. Cycle is still abnormal 3 months later, only dark blood spotting, no actual period. 2nd vaccine, tiredness/fatigue started the next morning, lasted approx. 12 hours. Itching started the next day 20Aug2021 lasted several hours and would episodically happen a few times a day x several days x about a week.  No Bilateral wheeze/bronchospasm, Stridor, Upper airway swelling, Respiratory distress, Tachypnoea, Increased use of accessory respiratory muscles, Recession, Cyanosis, Grunting, Dry cough, Hoarse voice, Difficulty breathing, Sensation of throat closure, Sneezing, Rhinorrhea, Cardiovascular, Measured hypotension, Shock, Tachycardia, Capillary refill time>3sec, Reduced central pulse volume  Decreased level of consciousness, Loss of consciousness, Generalized urticaria, Generalized erythema, Angioedema, Generalized Pruritus with skin rash, Generalized prickle sensation, Localized injection site urticaria, Red and itchy eyes, Gastrointestinal, Diarrhea, Abdominal pain, Vomiting.  Yes Dermatological/Mucosal, Generalized Pruritus without skin rash, Nausea Loss of menstrual cycle, still not normal x 3months. No event required the initiation of new medication or other treatment or procedure. Menstrual cycle is still abnormal but did have normal bleeding start on 13Nov2021. Patient did not received any recent vaccines for any other conditions prior to the event being reported, Patient did not received any recent vaccines for SARS-CoV2 other than Pfizer-BioNTech COVID-19 prior to the event being reported, patient did not received any other vaccines around the time of Pfizer-BioNTech COVID-19 vaccine vaccination.   No follow-up attempts are possible. No further information is expected