Herpes symptoms came back after the last 2 Moderna COVID-19 Boosters; After the first primary Moderna Shot, all Herpes symptoms stopped for about 1 month and exercising and drinking alcohol did not trigger a herpes reaction; This spontaneous case was reported by a patient and describes the occurrence of HERPES VIRUS INFECTION (Herpes symptoms came back after the last 2 Moderna COVID-19 Boosters) and THERAPEUTIC RESPONSE UNEXPECTED (After the first primary Moderna Shot, all Herpes symptoms stopped for about 1 month and exercising and drinking alcohol did not trigger a herpes reaction) in a 59-year-old male patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 prophylaxis.    Co-suspect product included non-company product TOZINAMERAN (PFIZER BIONTECH COVID-19 VACCINE) for an unknown indication.    Concurrent medical conditions included Herpes virus infection (Herpes breakout issues for 40 years. Herpes lesions broke out with different triggers as such drinking alcohol, and exercise. When was 20 years old, was exposed to Herpes (Broke out at least once a month).).   On 29-Apr-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 29-May-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. In 2022, received fifth dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On an unknown date, the patient received fourth dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form and third dose of TOZINAMERAN (PFIZER BIONTECH COVID-19 VACCINE) (unknown route) 1 dosage form. In 2021, the patient experienced THERAPEUTIC RESPONSE UNEXPECTED (After the first primary Moderna Shot, all Herpes symptoms stopped for about 1 month and exercising and drinking alcohol did not trigger a herpes reaction). On an unknown date, the patient experienced HERPES VIRUS INFECTION (Herpes symptoms came back after the last 2 Moderna COVID-19 Boosters). At the time of the report, HERPES VIRUS INFECTION (Herpes symptoms came back after the last 2 Moderna COVID-19 Boosters) and THERAPEUTIC RESPONSE UNEXPECTED (After the first primary Moderna Shot, all Herpes symptoms stopped for about 1 month and exercising and drinking alcohol did not trigger a herpes reaction) outcome was unknown.        For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown), the reporter did not provide any causality assessments.   Concomitant drugs were not reported.  It was reported that patient received 3rd Moderna monovalent booster prior to Sep-2022 and for first Pfizer Monovalent Booster unspecified date was reported as 29-Apr-2022. It was reported that after the first primary Moderna shot, all Herpes symptoms stopped for about 1 month and exercising and drinking alcohol did not trigger a herpes reaction. After the 2nd primary shot the herpes situation continued without symptoms, for the first time in 40 years patient had no herpes when exposed to triggers. The Pfizer booster did not had the same effect and it did not help the Herpes and had no same beneficial effect. Eventually the positive outcome wore off and Herpes symptoms came back. After the last 2 Moderna COVID-19 boosters, never again patient became totally without Herpes symptoms. But the severity of the symptoms improved and it was not as bad as it used to be. Patient thought that the dose amount in the primary Monovalent Moderna COVID-19 vaccine had contributed to the improvement of the Herpes symptoms.  Treatment medications were not provided.