he tried of get out of bed he could not move from the waist down.; he couldn't get out of bed; When he tried he almost fell; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP) from medical information team, Program ID.  An 82-year-old male patient received BNT162b2 (BNT162B2), on 26Aug2021 as dose 3 (booster), single (Lot number: FE3181) at the age of 82 years intramuscular, in arm for covid-19 immunisation. The patient's relevant medical history included: "He is immunocompromised" (unspecified if ongoing), notes: He is immunocompromised and has been under immunotherapy for 2 years.; "My husband has metastatic brain and lung cancer" (unspecified if ongoing), notes: My husband has metastatic brain and lung cancer.; "My husband has metastatic brain and lung cancer" (unspecified if ongoing), notes: My husband has metastatic brain and lung cancer.; "Metastatic melanoma Diagnosed latter part of Aug2020", start date: Aug2020 (unspecified if ongoing), notes: Metastatic melanoma Diagnosed latter part of Aug2020 had gamma knife treatment Sep2020; "had gamma knife treatment Sep2020", start date: Sep2020 (unspecified if ongoing), notes: Metastatic melanoma Diagnosed latter part of Aug2020 had gamma knife treatment Sep2020; "Cholesterol" (unspecified if ongoing), notes: Indication as Reported by the Primary Source: Cholesterol; "immunotherapy" (unspecified if ongoing), notes: Indication as Reported by the Primary Source: immunotherapy. Concomitant medication(s) included: ATORVASTATIN oral taken for blood cholesterol abnormal; OPDIVO intravenous taken for immunomodulatory therapy, start date: 2020. Vaccination history included: covid-19 vaccine (1st dose: Date: 09Feb2021. , Time: Morning, she doesn't know specific time, all boosters were in the morning., Anatomical Site of injection: arm, unknown which one. , Route of Administration: intramuscular; Batch/Lot number: EK9231, EXP: Apr2021. , HCP clinic site says (name-withheld), this could be (name-withheld).), administration date: 09Feb2021, when the patient was 82-year-old, for Covid-19 immunization; covid-19 vaccine (2nd dose: Date: 02Mar2021, Time: Morning, unknown what time. , Anatomical Site of injection: unknown arm. , Route of Administration: intramuscular; Batch/Lot number: EL3246, EXP: Apr2021. , HCP clinic site says (name-withheld), this could be (name-withheld).), administration date: 02Mar2021, when the patient was 82-year-old, for Covid-19 immunization; Flu vaccine (He has had no other vaccines ever than typical flu or pneumonia vaccines, which she can't remember when those were, they were not around the time of COVID-19 vaccines. He got one of the pneumonia vaccines, she doesn't remember when. He got the flu or pneumonia vaccines at (name-withheld) or (name-withheld).), for Immunization; Pneumonia vaccines (He has had no other vaccines ever than typical flu or pneumonia vaccines, which she can't remember when those were, they were not around the time of COVID-19 vaccines. He got one of the pneumonia vaccines, she doesn't remember when. He got the flu or pneumonia vaccines at (name-withheld) or (name-withheld).), for Immunization. The following information was reported: FALL (non-serious) with onset 26Aug2021, outcome "recovered", described as "When he tried he almost fell"; BEDRIDDEN (non-serious) with onset 26Aug2021, outcome "recovered", described as "he couldn't get out of bed"; DIPLEGIA (medically significant) with onset 26Aug2021, outcome "recovered", described as "he tried of get out of bed he could not move from the waist down.". Therapeutic measures were not taken as a result of diplegia, bedridden, fall.  Clinical information: When he had the first and second dose there was no problem. He was immunocompromised and had been under immunotherapy for 2 years. When he had the third dose in 26Aug2021, when we've gotten them before it was before noon. In the middle of the night, he went to the restroom and from the waist down he couldn't move his legs. When he got up in the morning, he was fine." Caller states she "brushed it off" and didn't call anyone. In Jul2022 he got "the fourth booster with the same side effect, in the middle of the night." When he went to have his immunotherapy treatment last week, she mentioned it because "they want him to keep getting boosters" due to his immunosuppression. They suggested they call the CDC or Pfizer to see if he should continue to take boosters in the concern that he may have a worse reaction the next time. Concomitant Medications: The only prescription her husband takes is Atorvastatin, which he has been on at least ten years. He also has immunotherapy, for a little over two years he has been on Opdivo immunotherapy. It was Sep2020 or Oct2020 when he started Opdivo. He has had no other vaccines ever than typical flu or pneumonia vaccines, which she can't remember when those were, they were not around the time of COVID-19 vaccines. He got one of the pneumonia vaccines, she doesn't remember when. He got the flu or pneumonia vaccines at (name-withheld) or (name-withheld).