Information has been received from a physician concerning a 15 year old female patient, who on 22-JUN-2009 was vaccinated with the first 0.5 ml dose of GARDASIL, intramuscularly. Concomitant therapy included ALEVE and ALLEGRA. On 25-JUN-2009 the patient had a 5 minute period where she was unresponsive, her fingers were stiff and she was generally dazed. On 18-AUG-2009 the patient was given a second 0.5 ml dose of GARDASIL, intramuscularly. On 20-AUG-2009 she had a similar episode that lasted 15-20 minutes. On 06-SEP-2009, the patient had another episode that lasted 30-40 minutes. She was brought to an ER. The hospital staff told her that they thought that is was a panic attack and told her to take potassium supplements. The mother decided to not complete the series. At the time of reporting the patient had recovered. Follow up information has been received from a physician via medical records concerning the patient with penicillin allergy and smoker who on 22-JUN-2009 was vaccinated with the first dose of GARDASIL (Lot number 0702X) IM in the left deltoid and on 18-AUG-2009 with the second dose of GARDASIL (Lot number 0162Y) IM in the right deltoid. Concomitant therapies included albuterol and multivitamin. On 06-SEP-2009, the patient presented to the emergency room with chief complaint of possible anxiety, trouble breathing. The patient was sitting in church and began having trouble breathing. Patient began increased breathing. The patient began tingling of face and contracture of hands. The patient had trouble talking. The episode resolved after breathing slowed. At the ER, the patient felt hot. The patient had similar episode recently at school, 2 weeks ago stated by the mother and lasted 10 minutes. The patient's initial temperature was 99.4, pulse 115, respiration 28, blood pressure 142/105 and SaO2 100 and the discharge pulse rate was 62, respiration 16, blood pressure 124/84 and SaO2 was 100. Electrocardiogram was performed and showed sinus bradycardia with a heart rate of 58 bmp. The neurological/physiological evaluation showed dizziness, numbness and difficulty with speech. The physical exam was normal. Blood work revealed the patient's potassium level was 3.3 and she received 20mEq of KCL. At 20:48, the patient was discharged stable, and was ambulatory. The admitting diagnosis was short of air and the clinical impression was palpitations, anxiety and hypokalaemia. On 08-SEP-2009, the patient's blood pressure was 116/70, temperature 99.1, pulse 59, RR 16 and SO2 98. The patient had facial paralysis and was seen in her physician's office. Regarding the patient's history present illness, she had a first episode at 05:00 of being glassy-eyed with hand cramp and increased breathing; the second episode was at 10:00, with the same symptoms (occurred at school); and with the third episode she went to the emergency room very glassy-eyed, she could not follow directions, and her hand and mouth were cramped. She did not remember all of event and she was sleepy when she came out of it. Review of systems showed: neurological as confusion and numbness, respiratory as tachypnic with no SOA, cardiological as palpitations and increased heart rate. The patient's past medical history and family history was unchanged. The physician's clinical impression was questionable seizure activity, "doesn't sound anxiety-related, especially with a history of head trauma". Physical exam (general, head, eyes, cardiac and physiological) was performed and normal. Patient had neuro exam and if negative, will have cardiac evaluation. On 22-OCT-2009, the patient's blood pressure was 126/64, temperature 92.3 and pulse 80. The patient did not have further episodes and doing fine. The patient's past medical history, social history and family history unchanged and the impression was questionable seizure-like activity post GARDASIL. The patient had physical exam, general and psychological were performed and normal. Physician instructed patient not to receive third dose of GARDASIL. On 18-NOV-2009, the patient's blood pressure was 118/80, temperature 98.0, pulse 68, RR 16 and SO2 95. At 11:55, the patient had an episode, the patient felt hot, appeared red in color with shaking and facial paralysis. The patient's history of present illness: she remained upright, she did not collapse. Her last meal was at 07:00 am and she had a soft drink at 10:15. The patient had finger constructions, muscles still sore and had no new anxieties. At 12:08, the patient's face flushed and did not space out. Regarding the past medical history, the social history and family history unchanged. The physical exam showed: GEN, alert and oriented and fatigue; eyes: pupil, ERRLA and psych: mood appropriate. Physician's impression was "recurrent episode". Physician wanted an EEG and her labs checked. On 20-NOV-2009 the patient presented to the ER at 15:10. The history of present illness was described as chief complaint of seizure, single episode, witnessed by her classmates. The patient was sitting in class, had an aura then a questionable seizure. The patient had generalized motor activity and then fatigue as postictal symptom and did not have injury. The patient's last menstrual period was on 01-NOV-2009. The patient had previous seizures as past medical history. The patient was treated with KEPPRA 500mg, oral, daily started 2 days ago. In the patient's physical exam, general appearance, EENT, neck/back, respiratory, CVS, abdomen, skin, extremities and neuro/psychological were normal. The clinical impression was seizure-like activity with stable condition and disposition at home. Regarding the emergency department documentation, the patient arrived at 14:40, ESI level 3, arrived by ambulance and the chief complaint was new seizure. The patient's temperature was 99.5, pulse 70, respiration 16, blood pressure 122/79 and weight 130 lbs. The assessment for airway, breathing, breath sounds, circulation, skin and disability were normal. The patient received a 20 gauge IV in the ambulance and her accucheck was 100 prior to arrival to the ER. The patient did not have chronic illness. The notes stated that at 14:45, the patient had seizure at school, had one last Wednesday, had seizure in September and the patient saw the physician on Wednesday. At 14:50, ambulatory to bathroom and was steady on feet. At 15:20, was instructed by the physician about medications. At 14:45, the patient's eyes open evaluation was 4 in Glasgow coma scale, best verbal response was 5 and best motor response was 6. At 15:20, eyes open was 4, best verbal response was 5 and best motor response was 6. The patient was discharged to home in stable condition with the ER's Clinical Impression of Seizure-like activity. Seizure activity was considered to be disability by the reporter. Additional information has been requested.