she had a reaction but handled and able to do all 3/anaphylaxis; The initial safety information received was reporting only non-serious adverse drug reaction(s), Upon receipt of follow-up information on 10Oct2022, this case now contains serious adverse reaction(s). Information processed together.  This is a spontaneous report received from a contactable reporter(s) (Consumer or other non-HCP) from medical information team, Program ID:  The reporter is the patient.  A female patient received BNT162b2 (BNT162B2), as dose 2, single (Batch/Lot number: unknown) for covid-19 immunisation; varicella zoster vaccine rge (cho) (SHINGRIX), as dose number unknown, single (Batch/Lot number: unknown) for immunisation. The patient's relevant medical history included: "Latex allergy" (unspecified if ongoing), notes: Anaphylactic reaction. Concomitant medication(s) included: FLU [INFLUENZA VACCINE] taken for immunisation as dose number unknown, single; PNEUMOCOCCAL VACCINE taken for immunisation as dose number unknown, single. Vaccination history included: Bnt162b2 (DOSE 1, SINGLE), for Covid-19 Immunization, reaction(s): "she had a reaction but handled and able to do all 3/anaphylaxis". The following information was reported: ANAPHYLACTIC REACTION (medically significant), outcome "unknown", described as "she had a reaction but handled and able to do all 3/anaphylaxis". Therapeutic measures were taken as a result of anaphylactic reaction.  Clinical course: Patient had 1 primary series and 2 booster shots of COVID-19 Vaccine and wanted to know if the 4th booster the liquid on the vial from Pfizer does not have latex on the vial because she had some immune issues and she took the Shingrix vaccine and experienced anaphylaxis and was on steroids. She wants to know if this was safe for her to take the 4th booster shot from Pfizer. Caller clarified details provided by the transfer agent. She stated that was little complicated and that was the reason she had an immunologist. She had the flu shot and pneumonia vaccine and was fine and then the Shingrix she had instant anaphylaxis and Pharmacist said was too quick to be anaphylaxis. Ultimately, she was able to discern and very carefully and both Shingrix and the reconstituted vial had latex and liquid had latex in the vial. The had warned her and that was the issue and prepared her. She was anything but antivaccine. Her immunologist came up with an allergy action plan. She called Pfizer and Moderna and the answer she got from both was that vial tops were latex base but liquid may or may not have latex in the liquid. The health department would not give her either vaccine. The pharmacist was willing to circumvent this. Her immunologist wrote her allergy action plan and started on steroids and on Pepcid. She would be with a senior pharmacist to take her blood pressure and do 30 minutes of observation and have her EpiPen. After doing successfully, she had a reaction but handled and able to do all 3. She was able to take 4th but that was different. She wanted to make an inquiry. The latex top she knows but need to know if risk for having a reaction and should not be taking steroids if not necessary and may compromise the vaccine and have the steroid does she take another dose of old one or wait for the new COVID-19 Vaccine. Caller declined report as she had an appointment and not prepared for a safety report. Step 1 in order for her to break them apart. If in fact needed to this works so well to take with or without the flu shot as she knew some people were receiving the vaccines together. Her immunologist said to take separate. Patient had a very dear friend who had a latex allergy and was a hospital pharmacist and was a teaching immunologist. Her experience had a latex allergy and getting an answer and avoid and should not have to take and was latex safe inside and out and be sad if forced to take steroids. She was already dealing with immune issues and why stress her body out. She trusts Pfizer. She needs an answer and leads her take to steroids that were not necessary.  Trained her from prior events and does not want to have an event and at same time if cannot get a clear answer should not have to take. She was an ally. She just had a Latex Allergy awareness week and pressing to get vaccination, and this was the issue. She had to work hand in hand. Question: Call received. Call originated from (withheld). E-transmitting potential AE duplicate report. Caller was a patient. Caller asked if Pfizer covid-19 booster, the new one, had latex in it. Caller said, I have had the 3 original vaccines and booster, the new have not had the new one. Nobody would give that to me, health department and pharmacist would not give that to me because I had interpolation for vaccines, she had me in succession with that together, I had flu then pneumonia vaccine, then had the shingrix vaccine and the final step was having the covid vaccine. We had carefully tracked those vials, the vial of vaccine and the reconstituting vial, both were labelled latex safe. Upon further investigation, the liquid inside, part that was injected to me, had latex in it, immediately put me into anaphylaxis. I am type I, when we got the inquiry we got a response, yes, the caps were latex safe however we cannot guarantee that the liquid inside or the reconstituting vial liquid may have a latex in it. Allergy reaction plan, take course of steroids, with antacid, take it before during and after, have an EpiPen. Told her if she would go fine with the first shot (covid vaccine) then she can go all three. I did have a reaction, but it was a very controlled. reaction. I was able to have all three. She had a choice to take it, she was taking cetirizine and Pepcid. I should not take steroids unless necessary, because she had already immune issues. We do not want to compound and make the vaccine less effective or omicron reaction worst by taking more steroids. We need a very clear answer. My hospital pharmacist friend with latex allergy made me understand my allergy. She knew that the top of the vial was supposedly latex free but based on her experience with Shingrix vaccine, that was not the case. Hospital pharmacist who gave birth as well, had more serious immune issues than I do. Going to get her flu shot today, I have not started taking the course of steroid, cetirizine and Pepcid. The reaction we have was not from the medicine it was from the latex. Caller said, pharmacist of a generic company, albuterol (cannot remember the manufacturer) had latex in it, the colorant did have latex. Was sent to hospital. They accidentally gave me albuterol due to respiratory distress with covid and was treated at home and found out other products with latex on it and zolpinex was on it.   The information on the batch/lot number for (BNT162B2), has been requested and will be submitted if and when received.