red toes; Swollen toes, thinks that this is called COVID toe. tip of the toes of her feet is swollen,; Nausea; Sore arm; Tachycardia; Clammy fingertips and toes; Breathing a little faster; Headache; Chills; This spontaneous case was reported by a consumer and describes the occurrence of VACCINATION SITE PAIN (Sore arm), TACHYCARDIA (Tachycardia), ERYTHEMA (red toes), SWELLING (Swollen toes, thinks that this is called COVID toe. tip of the toes of her feet is swollen,) and COLD SWEAT (Clammy fingertips and toes) in a 38-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch no. 001B21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     Concurrent medical conditions included Allergy to feathers (Allergy to cat fur). Concomitant products included MULTIVITAMINS [VITAMINS NOS] for an unknown indication.    On 10-Mar-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 11-Mar-2021, the patient experienced VACCINATION SITE PAIN (Sore arm), TACHYCARDIA (Tachycardia), COLD SWEAT (Clammy fingertips and toes), RESPIRATORY RATE INCREASED (Breathing a little faster), HEADACHE (Headache) and CHILLS (Chills). On 14-Mar-2021, the patient experienced NAUSEA (Nausea). On 15-Apr-2021, the patient experienced ERYTHEMA (red toes) and SWELLING (Swollen toes, thinks that this is called COVID toe. tip of the toes of her feet is swollen,). The patient was treated with DIPHENHYDRAMINE HYDROCHLORIDE (BENADRYL [DIPHENHYDRAMINE HYDROCHLORIDE]) for Rash over arms, at an unspecified dose and frequency and CETIRIZINE HYDROCHLORIDE (CETRIZINE) for Rash over arms, at an unspecified dose and frequency. On 15-Mar-2021, VACCINATION SITE PAIN (Sore arm), COLD SWEAT (Clammy fingertips and toes), HEADACHE (Headache), CHILLS (Chills) and NAUSEA (Nausea) had resolved. At the time of the report, TACHYCARDIA (Tachycardia), ERYTHEMA (red toes), SWELLING (Swollen toes, thinks that this is called COVID toe. tip of the toes of her feet is swollen,) and RESPIRATORY RATE INCREASED (Breathing a little faster) had resolved.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On 11-Mar-2021, Heart rate: 115 (High) 115 beats per minute.. On 12-Mar-2021, Electrocardiogram: normal (normal) Normal. On 26-Mar-2021, Blood immunoglobulin E: 4.3 (normal) 4.3 ug/L. On 26-Mar-2021, Electrocardiogram ambulatory: abnormal (abnormal) Tachycardia. On an unknown date, Blood pressure measurement: 130/90 (High) high.     mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosing remained unchanged.   For mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular), the reporter considered VACCINATION SITE PAIN (Sore arm), TACHYCARDIA (Tachycardia), ERYTHEMA (red toes), SWELLING (Swollen toes, thinks that this is called COVID toe. tip of the toes of her feet is swollen,), COLD SWEAT (Clammy fingertips and toes), RESPIRATORY RATE INCREASED (Breathing a little faster), HEADACHE (Headache), CHILLS (Chills) and NAUSEA (Nausea) to be possibly related.    No treatment medications were reported.  On 26-Mar-2021, Lab test Mast cell tryptase was performed and the results were 30.2 kU/L Normal.  After first dose, the patient woke up with tachycardia and shallow breathing. The patient had on and off tachycardia  after that was advised Holter monitor for two weeks. The patient was advised to take second dose which was delayed just before six weeks past first dose.  The patient was advised over the counter Pataday 0.2 percent ophthalmic solution at the dose of one drop in each eye daily as need for ocular symptoms.   This case was linked to MOD21-074108 (E2B Linked Report). This case was linked to MOD-2021-280220 (Patient Link).   Most recent FOLLOW-UP information incorporated above includes: On 08-Aug-2021: Reporters address, patient initial, lab data, event outcome, causality of the event was added and updated narrative; Sender's Comments:  MOD21-074108: