thyroid numbers were upside down/hyperthyroid; like I have the flu/very flu-ish; heart is racing all the time/my heart will not calm down; ears are ringing; stomach is upset; stressed out; I don't feel well; arm pain; I could not lift my arm for 3 days; TIRED; This spontaneous case was reported by a consumer and describes the occurrence of HYPERTHYROIDISM (thyroid numbers were upside down/hyperthyroid) in a 52-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch no. 050E21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     The patient's past medical history included Graves' disease, Hashimoto's disease, Raynaud's disease, Depression and COVID-19. Concomitant products included LEVOTHYROXINE, NALTREXONE and BUPROPION HYDROCHLORIDE (WELLBUTRIN) for an unknown indication.    On 27-Sep-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) .5 milliliter. On an unknown date, the patient experienced HYPERTHYROIDISM (thyroid numbers were upside down/hyperthyroid) (seriousness criterion medically significant), INFLUENZA LIKE ILLNESS (like I have the flu/very flu-ish), PALPITATIONS (heart is racing all the time/my heart will not calm down), TINNITUS (ears are ringing), ABDOMINAL DISCOMFORT (stomach is upset), STRESS (stressed out), MALAISE (I don't feel well), PAIN IN EXTREMITY (arm pain), LIMB DISCOMFORT (I could not lift my arm for 3 days) and FATIGUE (TIRED). The patient was treated with PARACETAMOL (TYLENOL) at a dose of 1 dosage form. At the time of the report, HYPERTHYROIDISM (thyroid numbers were upside down/hyperthyroid), INFLUENZA LIKE ILLNESS (like I have the flu/very flu-ish), PALPITATIONS (heart is racing all the time/my heart will not calm down), TINNITUS (ears are ringing), ABDOMINAL DISCOMFORT (stomach is upset), STRESS (stressed out), MALAISE (I don't feel well), PAIN IN EXTREMITY (arm pain), LIMB DISCOMFORT (I could not lift my arm for 3 days) and FATIGUE (TIRED) outcome was unknown.        The action taken with mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) was unknown.   For mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular), the reporter did not provide any causality assessments.   Patient  talked to a HCP the day after receiving the vaccine and after receiving blood work that day. Her thyroid numbers were "upside down." She went from hypothyroid to hyperthyroid. She also talked to her HCP yesterday who recommended she not receive the second dose of the vaccine and wrote her a note. They also altered her thyroid medications. She has also previously filled out VAERS. She has also sent a message to another healthcare professional, but they have not responded yet.  Company comment: This case concerns 52-year-old female patient with medical history of Graves' disease, Hashimoto's disease, Raynaud's disease, depression and COVID-19, who experienced the  unexpected event of hyperthyroidism. The event occurred  on an unknown date after the first dose of mRNA-1273 (COVID-19 Vaccine Moderna).  The rechallenge was not unknown as no dosing detail was disclosed. Causality for the reported event was not provided by the reporter. The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report. Events were assessed as serious as event is a medically important event.  Event is confounded by the patient's underlying history of grave's disease.; Sender's Comments: This case concerns 52-year-old female patient with medical history of Graves' disease, Hashimoto's disease, Raynaud's disease, depression and COVID-19, who experienced the  unexpected event of hyperthyroidism. The event occurred  on an unknown date after the first dose of mRNA-1273 (COVID-19 Vaccine Moderna).  The rechallenge was not unknown as no dosing detail was disclosed. Causality for the reported event was not provided by the reporter. The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report. Events were assessed as serious as event is a medically important event.  Event is confounded by the patient's underlying history of grave's disease.