the heart condition he now has is called Prinz-metal; heart attack; passed out; food poisoning; blood pressure changes /blood pressure dropped; blood pressure dropped; sweating; palpitations; heart rate was 172 /heart rate came up /high heart rate; stress; angina when he is resting and "it hurts like you know what; high blood pressure; worried; This case was reported by a consumer via call center representative and described the occurrence of prinzmetal angina in a 65-year-old male patient who received Herpes zoster (Shingrix) for prophylaxis.   The patient's past medical history included prinzmetal angina, rhizotomy (25 years, ago before reporting), ophthalmic herpes zoster (patient went to emergency room where he was diagnosed with Shingles, it affected his eye.), herniated disc (25 years, ago before reporting), back injury (25 years, ago before reporting) and wasp sting (severe). Previously administered products included valacyclovir (for the Shingles, The patient had been off those medications for a long time before day of reporting.), oxycodone (for the Shingles, The patient had been off those medications for a long time before day of reporting.) and shingrix with an associated reaction of pain in extremity (1st dose received on 20th August 2019).   On 4th November 2019, the patient received the 2nd dose of Shingrix. On an unknown date, 1 day after receiving Shingrix, the patient experienced prinzmetal angina (serious criteria GSK medically significant), heart attack (serious criteria GSK medically significant), food poisoning, change in blood pressure, blood pressure decreased, sweating, palpitation, heart rate increased, stress, pain, blood pressure high, worry and passed out (serious criteria GSK medically significant). On an unknown date, the outcome of the prinzmetal angina, heart attack, food poisoning, blood pressure decreased, stress, pain, blood pressure high, worry and passed out were unknown and the outcome of the change in blood pressure, palpitation and heart rate increased were not recovered/not resolved and the outcome of the sweating was recovered/resolved.   It was unknown if the reporter considered the prinzmetal angina, heart attack, food poisoning, change in blood pressure, blood pressure decreased, sweating, palpitation, heart rate increased, stress, pain, blood pressure high, worry and passed out to be related to Shingrix.  Additional case details were reported as follows: The patient was retired but active, biking. The patient reported blood pressure before Shingrix in the 120/80 to 90 range. The patient reported a bad reaction to Shingrix involving a heart condition. The pharmacist did not mix the 2nd dose in front of the patient and the patient not experienced arm soreness. After the 2nd shot his blood pressure dropped but his heart rate came up and he thought he was going to pass out.  After Shingrix the reported blood pressures were 166/104 and 174/95. The patient went to the emergency room after his second shot and was told he was having palpitations. At the time of reporting, the patient heart condition was called as Prinz-metal angina. He said it was very severe. It had been changed his life so much and he stated that he knows that Shingrix was what caused it because it happened the next day after the injection.  The patient told it was called a heart attack but really it was food poisoning and then he went to work and had stress. The patient told that he only had angina when he was resting and it felt like hurts. The patient told that it also causes a high heart rate and high blood pressure. The patient described heart rate fluctuations and checking his watch heart rate monitor frequently. The patient started sweating at a theater, his watch said his heart rate was 172.  The patient unable to volunteer at the pantry because they were worried he would die there.  The reason, the patient called back was because he wanted to know if anyone in the clinical trials had died from this condition.  The physician spoken from the package insert regarding death percentages vs. placebo. The physician explained that his health care professional could contact medical information for more information. The patient mentioned that he had seen a cardiologist in the past but it was a long time before day of reporting and his (pre-existing) medications (unspecified) had been reduced. The patient reported that heart rate increases and blood pressure changes the attributes to Shingrix, which were out of control changing patient's life. The patient was then referred to cardiologist office. The patient enquired whether he get the first injection twice. The patient caller back to physician and also spoken from dosage and administration section of package insert. The reporter consented to follow up. The patient was retired but active, biking.  The reason, the patient called back was because he wanted to know if anyone in the clinical trials had died from this condition.  The physician spoken from the package insert regarding death percentages vs. placebo. The physician explained that his health care professional can contact medical information for more information. The patient mentioned that he had seen a cardiologist in the past but it was a long time before day of reporting and his (pre-existing) medications (unspecified) had been reduced. The patient reported that heart rate increases and blood pressure changes the attributes to Shingrix which were out of control changing patient's life. The patient was then referred to cardiologist office.  The patient enquired whether he get the first injection twice. The reporter consented to follow up.      Lab Comments: On an unknown date lab tests were performed.