Covid-19 vaccine might have jump started Alzheimer's; Altered mental status; Patient meant he saw things, he talked to people and he was terrible; Depression; Shaking; Went berserk / He is just crazy. Saying and seeing things that was not there; This is a spontaneous report a contactable consumer (wife).  An 82 years old male patient (Height: 170 cm and Weight: 66.68 kg) received the second dose of BNT162B2 (Pfizer-Biontech Covid-19 Vaccine, Lot Number: EN6201) intramuscularly, in the right arm, at single dose, on 13Feb2021 at 10:20, for COVID-19 immunization. Relevant medical history included high cholesterol, high triglycerides and high blood pressure, all from an unspecified date, all diagnosed at least 10 or 15 years and acid reflux (esophageal), from an unspecified date. The patient previously, on 19Jan2021, received the first dose of BNT162B2 (Pfizer-Biontech Covid-19 Vaccine, Lot Number: EL3249) at single dose, in the left arm, for COVID-19 immunization. After the first dose, the patient experienced shaking ("the patient was a little shaky following the first dose of the Covid-19 vaccine on 19Jan2021, but it was nothing major") and was nervous ("the wife reported that when it was time to get the second dose on 13Feb2021, the patient was so nervous to get the shot that he was too nervous to drive"). Concomitant medications included hydrochlorothiazide 12.5 mg, once daily, in the morning, from an unspecified date to Apr2021, for high blood pressure; eicosapentaenoic acid ethyl ester (VASCEPA) 1 mg, twice daily, from an unspecified date to Apr2021, for blood triglycerides; atorvastatin 40 mg, once daily, from an unspecified date to Apr2021, for blood cholesterol; omeprazole from an unspecified date, for an unknown indication; colecalciferol (VITAMIN D (colecalciferol)) from an unspecified date, for an unknown indication and an unspecified multi vitamins. On 13Feb2021, the patient experienced altered mental status, illusion ("patient meant he saw things, he talked to people and he was terrible. He was saying people called to him. He wanted to go outside; vision illusions like people were calling him to come outside"), depression, shaking and he was feeling abnormal ("he went berserk. He was just crazy. Said and saw things that was not there. Patient was hearing people calling him to go outside"). The patient might have Alzheimer's. Patient's wife reported that the physician stated that the Covid-19 vaccine might have jump started Alzheimer's. Treatment was received. Patient was prescribed donepezil, ondansetron, quetiapine, escitalopram, trazodone, and sertraline after he went berserk to help with altered mental status. None of the medications worked. Patient also received risperidone. Patient's wife reported that even with the risperidone, the patient was not his complete self like he was before he received the Covid-19 vaccine. Risperidone helped some. Relevant laboratory tests, performed on an unspecified date, in 2021, included: computerised tomogram head (CT brain scan) normal, lumbar puncture (Spinal tap) normal, and magnetic resonance imaging head (MRI brain) normal. Clinical outcome of the events was unknown at time of this report.