This is a spontaneous report from a contactable consumer or other non hcp (patient, self-reported). A 80-years-old male patient received first dose of BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE, Solution for injection, Lot number: ER8735, Expiration date 31 Jul 2021), via an unspecified route of administration in right arm on 22Apr2021 at 10:30 as single dose for COVID-19 immunization. Medical history included malignant melanoma from an unknown date in Dec 2019 (ongoing), illness from an unknown date. Concomitant medications included nivolumab (240 mg/m2) taken for malignant melanoma, start and stop date were not reported. The patient previously took penicillin b and experienced hypersensitivity. On 22Apr2021 patient got the 1st dose and on 25Apr2021, The patient experienced he broke out in a rash/he says the red dots are still there on his body with outcome of not recovered, itching with outcome of not recovered , his is a little blurry with outcome of unknown , rashes all over his stomach with outcome of unknown. The patient underwent lab tests and procedures which included positron emission tomograms on 19 Jan 2021.  Therapeutic measures were taken as a result of he broke out in a rash/he says the red dots are still there on his body (rash), itching (pruritus). The CDCs Advisory Committee on Immunization Practices (ACIP) has provided interim considerations for the use of COVID-19 mRNA vaccines (like the Pfizer-BioNTech COVID-19 Vaccine) during the Emergency Use Authorization.  These interim considerations state that antihistamines (like diphenhydramine) should not be taken prior to vaccination to prevent allergic reactions, including anaphylaxis (anaphylaxis is a serious and potentially life-threatening allergic reaction). Follow-up on (26Apr2021): The patient took COVID 19 vaccine to protect his wife and himself for immunity against COVID 19. He said that is a fusion solution and he started taking this a month after the doctor cut the melanoma out of his head and it was cancerous, clarified as melanoma and he is on the last treatment. On the last PET scan, there was no melanoma on any place on his body. He says the PET scan was probably at least 2 months ago. He says he had a "C scan" last week but he hasn't gotten the results of that. He stated that took a couple Benadryl and it doesn't seem to be quite as bad as it was. He says the red dots are still there on his body. He confirms the rash has improved a little bit. He initially provides the Lot number ER3735. He has trouble reading his vaccination card, stating his is a little blurry. He gets his wife's card to compare as him and his wife received the vaccine at the same time. He explains his wife's card says ER8735, he believes the Lot number is probably the same on his card but the top part of the number 8 isn't connected and it made it look like an 8. He gets his magnifying glass out and confirms the Lot number is ER8735. He says that this is his first dose of the COVID-19, The patient did not receive any other vaccine in four weeks. The outcome of the events rash and itching was recovered and the outcome event little blurry was unknown. No Follow-up attempts are needed. No further information expected.