asthma flare up; Hard to remember; can't remember things; can't find things in house; Autoimmune problem flared up, itchy skin and congestion after IGE injection and pneumovax injection; Back hurts; Don't feel good all the time; More confused since starting Tymlos; Hypoparathyroidism diagnosis hormone / Feeling tired all the time; This spontaneous report was received from a 77-year-old female patient. The patient concurrent conditions included severe osteoporosis for ten years, asthma, immune system disorder, psychological conditions, stevens-johnson syndrome, allergies, autoimmune disorder, insomnia and osteoporosis postmenopausal. The patient's medical history included crohn's disease, irritable bowel syndrome, cataract and cataract operation. The patient's concomitant therapies included prednisone (manufacturer unknown), alprazolam (XANAX), unspecified psychological medications, asthma inhaler and calcium.     On 06-SEP-2019, the patient started therapy with abaloparatide (TYMLOS) 80 mcg, daily, subcutaneous injection for postmenopausal osteoporosis.   Since 06-SEP-2019, the patient had experienced headache which radiated into her eye, an increase of her asthma symptoms and she also stated that she could not sleep. The patient took alprazolam (XANAX) for her sleep and inhaler for her asthma; however, she stated that none of them had been working since she had been taking abaloparatide (TYMLOS).   Upon follow up, the patient was using pliers or a wrench to remove needles almost every day and did not prime each pen before first use. She also had an autoimmune problem that flared up and due to the event the patient received  an immunoglobulin (lgE) injection (dose, frequency, route of administration, lot number and expiration date were not reported) and pneumococcal vaccine, polyvalent (23-valent)(PNEUMOVAX23) injection (dose, route of administration, anatomical location, lot number and expiration date were not reported).   On an unspecified date in 2019, after the two injections the patient stated that she had an asthma flare up, itching skin and congestion (Condition aggravated). The patient notified her Immunologist. Upon follow up, the patient was on her third abaloparatide (TYMLOS) pen. Then, the patient stated that she could not remember things and could not find things in her house (Memory impairment). The patient reported that her healthcare provider (HCP) diagnosed her with hypoparathyroidism and she was referred to an endocrinologist. Additionally, the patient reported that she did not feel good all the time (Malaise), her back hurt (Back pain), she felt tired all the time and since starting abaloparatide (TYMLOS) had felt more confused all the time (Confusional state).   As of 06-DEC-2019, abaloparatide (TYMLOS) therapy was reported as ongoing, the action taken with immunoglobulin (lgE) was unknown. The outcome of asthma, hypoparathyroidism, confusional state, malaise, back pain, condition aggravated, and memory impairment was unknown. The reporter did not provide causality assessment between the events and the suspect therapies abaloparatide (TYMLOS), pneumococcal vaccine, polyvalent (23-valent) (PNEUMOVAX23) and  immunoglobulin (lgE).