headache; asthma got worse; wheeze; have more difficulty breathing; This is a spontaneous report received from contactable reporter(s) (Nurse). The reporter is the patient.  A 46-year-old female patient received BNT162b2 (BNT162B2), on 26Feb2022 at 13:00 as dose 3 (booster), single (Lot number: 025L273) at the age of 46 years intramuscular, in left deltoid for covid-19 immunisation. The patient's relevant medical history included: "Asthma" (ongoing), notes: 30 yrs ago; "Menometrorrhagia" (ongoing), notes: about 2 yrs ago; "Mastalgia" (ongoing), notes: about 1 year; "Migraine" (ongoing), notes: about 20 yrs. Concomitant medication(s) included: ALVESCO taken for asthma, start date: Nov2021 (ongoing); METHOCARBAMOL oral taken for pain, start date: Nov2021, stop date: 31Dec2021; GABAPENTIN oral taken for pain, start date: Nov2021 (ongoing); RIZATRIPTAN oral taken for migraine (ongoing). Vaccination history included: BNT162b2 (DOSE 1, SINGLE ; administration time=12:00 PM, vaccine location=Left arm, Route of administration: Intramuscular, Pfizer/BioNTech Covid-19 Vaccine details:, Dose: 1st, Date/time, Date: 21Dec2020, Time: 17:00 (approximate), Site and route of injection, Anatomical Site of injection: left Deltoid, Route of administration: Intramuscular (checked), Batch/Lot number: EJ1685), administration date: 21Dec2020, for Covid-19 immunization; BNT162b2 (DOSE 2, SINGLE ; administration time=12:00 PM, vaccine location=Left arm, Route of administration: Intramuscular, Pfizer/BioNTech Covid-19 Vaccine details:, Dose: 2nd, Date/time, Date: 10Jan2021, Time: 17:00 (approximate), Site and route of injection, Anatomical Site of injection: left Deltoid, Route of administration: Intramuscular (checked), Batch/Lot number: EL1283), administration date: 10Jan2021, for Covid-19 immunization. The following information was reported: HEADACHE (non-serious), outcome "unknown"; ASTHMA (non-serious), outcome "unknown", described as "asthma got worse"; WHEEZING (non-serious), outcome "unknown", described as "wheeze"; DYSPNOEA (non-serious), outcome "unknown", described as "have more difficulty breathing". Relevant laboratory tests and procedures are available in the appropriate section.  Additional information: She did not receive any other vaccine prior to Covid 19 vaccine. She received the vaccine at Workplace clinic. Upon receiving the second dose she experienced binding headache within the hour of receiving the vaccine, lost memory for 24 hours and experienced diarrhea and vomiting for 7 days with 6 days having fevers above 101 F was tested and her covid test was negative. Her skin began to dry and experienced horrible itching and burning sensation all over different parts of her body. The headaches we so intense she went to urgent care twice was given pain shot with no relief. Pain moved to neck and all through body. Some experienced with third shot but less intense. The headache from the second shot never went away. She live with headache every day. It's only a matter of how strong and crippling the pain would get. Her asthma got worse as well. She started to wheeze and have more difficult breathing. Her asthma has been so bad. She had to have her medication changed. She performed the Head CT for non-stop ongoing headache which was normal. Specific relevant test for thromboembolic events with thrombocytopenia were none.