Big blister forming on the left side of my bottom lip; My bottom lip was painful; My bottom lip was swollen with tingling; tTe lymph node in my left armpit was painful; The lymph node in my left armpit was swollen; Arm pain at the injection site; I had a fever; My bottom lip started swelling on left side; I was running warm; Having hot flashes; Chest tightness; I felt tired; This spontaneous case was reported by a consumer and describes the occurrence of LIP SWELLING (My bottom lip started swelling on left side), FEELING HOT (I was running warm), HOT FLUSH (Having hot flashes), CHEST DISCOMFORT (Chest tightness) and PARAESTHESIA ORAL (My bottom lip was swollen with tingling) in a 26-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch no. 013F21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     No Medical History information was reported.    On 29-Nov-2021, the patient received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 29-Nov-2021, the patient experienced FATIGUE (I felt tired). On 30-Nov-2021, the patient experienced LIP SWELLING (My bottom lip started swelling on left side), FEELING HOT (I was running warm), HOT FLUSH (Having hot flashes), CHEST DISCOMFORT (Chest tightness), LYMPH NODE PAIN (tTe lymph node in my left armpit was painful), LYMPHADENOPATHY (The lymph node in my left armpit was swollen), VACCINATION SITE PAIN (Arm pain at the injection site) and PYREXIA (I had a fever). On 01-Dec-2021, the patient experienced PARAESTHESIA ORAL (My bottom lip was swollen with tingling) and LIP PAIN (My bottom lip was painful). On 02-Dec-2021, the patient experienced LIP BLISTER (Big blister forming on the left side of my bottom lip). The patient was treated with IBUPROFEN (ADVIL [IBUPROFEN]) at an unspecified dose and frequency and DIPHENHYDRAMINE HYDROCHLORIDE (BENADRYL [DIPHENHYDRAMINE HYDROCHLORIDE]) at a dose of 25 milligram. At the time of the report, LIP SWELLING (My bottom lip started swelling on left side), FEELING HOT (I was running warm), HOT FLUSH (Having hot flashes), CHEST DISCOMFORT (Chest tightness), PARAESTHESIA ORAL (My bottom lip was swollen with tingling), LIP BLISTER (Big blister forming on the left side of my bottom lip), LIP PAIN (My bottom lip was painful), LYMPH NODE PAIN (tTe lymph node in my left armpit was painful), LYMPHADENOPATHY (The lymph node in my left armpit was swollen), VACCINATION SITE PAIN (Arm pain at the injection site), PYREXIA (I had a fever) and FATIGUE (I felt tired) outcome was unknown.            No concomitant medicines were reported. On 30-Nov-2021: Morning bottom lip started swelling on left side, the lymph node in my left armpit was swollen and painful had a fever. The patient was running warm and having hot flashes. The patient had arm pain at the injection site and  chest tightness. The patient  took Advil. The patient took Benadryl 25mg that evening. On 02-Dec-2021: The patient had a big blister forming on the left side of bottom lip. The right side was going down.   This case was linked to MOD-2021-403814, MOD-2021-403815 (Patient Link).   Most recent FOLLOW-UP information incorporated above includes: On 02-Dec-2021: Followup document received: Non significant information.