Throwing up blood (called 911); No feeling in leg (called 911)/no feeling in my right leg; Couldn't walk (called 911); Feel like garbage (called 911); Can't lift head (called 911)/still laying on the floor; Fell, can't get off the floor (called 911); Can't keep anything down, throwing up (called 911); Arm hurts (called 911); Speech was slurred (called 911); This case was reported by a consumer via call center representative and described the occurrence of vomiting blood in a 56-year-old female patient who received Herpes zoster (Shingrix) for prophylaxis.   The patient's past medical history included gastric operation (had gastric surgery in April 2022). Previously administered products included Shingrix (received 1st dose on 23rd September 2022).   On 5th February 2023, the patient received the 2nd dose of Shingrix. On 6th February 2023, 1 days after receiving Shingrix, the patient experienced vomiting blood (serious criteria GSK medically significant), loss of sensation, unable to walk, feeling unwell, muscle weakness, fall, vomiting, pain in arm and slurred speech. On an unknown date, the outcome of the vomiting blood, loss of sensation, unable to walk, feeling unwell, muscle weakness, fall, vomiting, pain in arm and slurred speech were not recovered/not resolved.   It was unknown if the reporter considered the vomiting blood, loss of sensation, unable to walk, feeling unwell, muscle weakness, fall, vomiting and slurred speech to be related to Shingrix. The reporter considered the pain in arm to be related to Shingrix.     Additional Information: GSK receipt date: 6-Feb-2023 Reporter's comment:  The reporter is the patient. The patient reported that received Shingrix shot of Shingrix on 5th February 2023. The patient was felt like garbage on the day of reporting,  The patient had trouble like no feeling in right leg at all. The patient fell down before. The patient thought she could walk and she couldn't.  The patient was assuming that was not normal. The patient felt like garbage but she expected that she could even lift my head up its that bad.  The patient live alone and was trying to do something and fell so she was still laying on the floor. She had not been able to get off the floor yet and it had been like 2 hours now. The patient coul not get off the floor. She did not want to go to the hospital. She just want to make sure this was one of the symptoms that might be happening and hopefully it would clear itself up soon. The patient was laying on bathroom floor. She would just wait till her landlord comes home at 7:30. The patient was throwing up blood too. she ate breakfast. She had oatmeal for breakfast and that came right back up ever since then she could not keep any liquids down she could not keep anything down it just keeps coming up. And now that the patient had nothing in system. The arm hurt - knew that would happen. She also mentioned that her speech was slurred.  She refused to call doctor. The call center representative offered to call an ambulance for her; she refused. She indicated she would not be able to get to the door to open it for them and that her landlord would kick her out if they broke the door down. Call ended abruptly because she stated her phone battery was dying. Additional supportive information: From the narrative it seems that the event started on the day of reporting hence onset date captured as 6 Feb 2023.