I am an acute care pediatric Nurse practitioner, who has Relapsing Remitting Multiple Sclerosis. I received the second Moderna vaccine on 2/2/2021 @ 11:00. At 5:00 pm, I developed the most intense painful headache I have ever had in my life along with an extreme, crushing pain to my hands and feet, almost as if my hands and feet were in a vice grip and someone was tightening the vice. At 11 pm on 2/2/21, I developed a 101.1 temperature, chills and flu-like pain to the rest of my muscles/joints. The temperature, chills and flu-like pain lasted for 36 hours. The headache and vice-like pain were constant and lasted for 23 days. There was no relief despite numerous measures to ease pain. I am an acute care pediatric Nurse practitioner, who has Relapsing Remitting Multiple Sclerosis. I received the second Moderna vaccine on 2/2/2021 @ 11:00. At 5:00 pm, I developed the most intense painful headache I have ever had in my life along with an extreme, crushing pain to my hands and feet, almost as if my hands and feet were in a vice grip and someone was tightening the vice. At 11 pm on 2/2/21, I developed a 101.1 temperature, chills and flu-like pain to the rest of my muscles/joints. The temperature, chills and flu-like pain lasted for 36 hours. The headache and vice-like pain were constant and lasted for 23 days. There was no relief despite numerous measures to try and ease the pain, including, but not limited to: Prescribed pain medication: Toradol, Fioricet with/without Codeine, Tylenol #3 OTC analgesics/NSAIDS: Aleve, Ibuprofen, Tylenol, Aspirin Non-pharmacological measures: Deep tissue and scalp massage, Tiger Balm to temple area and hands/feet, heat packs, cold packs, meditation, relaxation breathing, cryo pool. In addition to the symptoms listed above, I have began having new and very concerning MS symptoms since the second Moderna injection. Some of these symptoms occur on a daily basis, while others are present at least 3+ days a week. Prior to 2/2/2021, my MS was very stable, without relapses and I had very rare symptomatology (occasional muscle cramps/spasms, occasional muscle/joint discomfort, occasional migraine/headache since childhood and on a very rare occasion - problems with word finding). I do have moderate heat intolerance as a baseline. These new symptoms made their presence since 2/2/2021: 1) Worsening of my heat intolerance (sweating in 70 degree temperatures) DAILY, 2) Daily headaches (6-10/10) without relief from analgesics, etc, 3) Menstrual irregularity, 4) Insomnia (4+ nights a week), 5) Interrupted sleep (cannot sleep more than 2 straight hours at a time), 6) Fatigued and very little energy, 7) Flu aches (3+ times a week), 8) Feeling light headed/dizzy 4-5 times a week, 9) Problems with balance every day (from 2/3/2022, I have had to hold onto the wall in the shower, because I lose my balance, which I never had to do before. 10) Muscle cramping/spasms -at least 4-5 days a week, 11) Muscle fatigue and weakness. I am unable to stand up from squatting without having something to hold onto as I pull myself up, where as I could do squats and work out in the gym without a bar to hold onto for balance.  My legs are weak after one flight of stairs and I feel like I am walking in "quick sand" most every day. 12) My voice has changed, and I have hoarseness at least 2-3 times a week. Sometimes I lose my voice without any type of upper respiratory infection or illness present. I will be singing or talking, and my voice will become "froggy" in sound or no sound will come out. 13) I feel palpitations often, and not with caffeine consumption. 14) Bladder spasms, urinary frequency, nocturia (2-3 times a week) 15) Flushing to face and sweating with eating  5+ times a week. 16) Visual disturbances and frequent blurry vision episodes (at least 3-4 times a week). 4/9/2021 - I had appendicitis 2 months after the second injection, that caused me to be hospitalized for 48 hours.  Surgery not indicated, but completed a 14 day course of oral antibiotics. 7/12/2022 - I had TIA like symptoms 5 months after the second injection, and was hospitalized for 24 hours. Brain CT ruled out TIA/stroke and the brain MRI did not reveal any new or active MS brain lesions, so I was diagnosed with "Pseudoflare".  Please remember, that I have not had any relapses in the 10 years since I have been diagnosed, only my initial presenting symptom of optic neuritis in 2012. I continue to work full time (40+ hours a week), but after writing all of my symptoms down throughout the year, I felt I should report them.