body shaking; When waking up from sleep she would also be drenched in sweat; lost 15 to 20 lbs; lost muscle mass; blood pressure is spiking; a mess/ life has been destroyed/everything that has been going on, everything that has been going on,she is now out of work on medical leave; torso started burning (on the front and back of her body, along her spine, under heart, and stomach); head started burning/scalp was on fire; extremely sick and went downhill from there; head started itching; This spontaneous case was reported by a consumer and describes the occurrence of TREMOR (body shaking), HYPERHIDROSIS (When waking up from sleep she would also be drenched in sweat), ILLNESS (extremely sick and went downhill from there), PRURITUS (head started itching) and BURNING SENSATION (torso started burning (on the front and back of her body, along her spine, under heart, and stomach)) in a 51-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 067F21A, 014C21A and 036B21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     Previously administered products included for Product used for unknown indication: Seasonal Flu (Seasonal Flu Vaccine ,intramuscular, unknown lot and unknown brand.) in September 2021. Past adverse reactions to the above products included No adverse event with Seasonal Flu. Concurrent medical conditions included Allergy to antibiotic (Allergy to erythromycin) and Allergy to antibiotic (Allergy to Z-Pack).   On 04-Apr-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) .5 milliliter. On 02-May-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to .5 milliliter. On 19-Nov-2021, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to .25 milliliter. On 28-Dec-2021, the patient experienced ILLNESS (extremely sick and went downhill from there), PRURITUS (head started itching) and SKIN BURNING SENSATION (head started burning/scalp was on fire). On 30-Dec-2021, the patient experienced BURNING SENSATION (torso started burning (on the front and back of her body, along her spine, under heart, and stomach)). On an unknown date, the patient experienced TREMOR (body shaking), HYPERHIDROSIS (When waking up from sleep she would also be drenched in sweat), ABNORMAL LOSS OF WEIGHT (lost 15 to 20 lbs), MUSCLE ATROPHY (lost muscle mass), HYPERTENSION (blood pressure is spiking) and IMPAIRED WORK ABILITY (a mess/ life has been destroyed/everything that has been going on, everything that has been going on,she is now out of work on medical leave). The patient was treated with HYDROCHLOROTHIAZIDE for Blood pressure management, at a dose of 25 milligram once a day and VALSARTAN for Blood pressure management, at a dose of initially 160 mg daily, now 320 mg at bedtime. In January 2022, SKIN BURNING SENSATION (head started burning/scalp was on fire) had resolved. At the time of the report, TREMOR (body shaking), HYPERHIDROSIS (When waking up from sleep she would also be drenched in sweat), ILLNESS (extremely sick and went downhill from there), PRURITUS (head started itching), BURNING SENSATION (torso started burning (on the front and back of her body, along her spine, under heart, and stomach)), ABNORMAL LOSS OF WEIGHT (lost 15 to 20 lbs), MUSCLE ATROPHY (lost muscle mass), HYPERTENSION (blood pressure is spiking) and IMPAIRED WORK ABILITY (a mess/ life has been destroyed/everything that has been going on, everything that has been going on,she is now out of work on medical leave) had not resolved.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On an unknown date, Blood pressure measurement: blood pressure spikes (High) blood pressure spikes. On an unknown date, Weight: lost 15 to 20 lbs (Low) lost 15 to 20 lbs..         Concomitant medication included blood pressure treatment medications and does not take any other daily medications.  After receiving the Moderna booster dose on 19 Nov 2021, approximately one or two weeks later patient started experiencing weird side effects that included body shaking (when she would sit up) and when waking up from sleep she would also be drenched in sweat.  Patient initially ignored these events but on 28 Dec 2021 started with other more events.  The head started itching and burning and her scalp was on fire. Patient initially thought she may have dandruff or psoriasis of the scalp and treated with an OTC dandruff shampoo, but it did not help.  she went to see a dermatologist on 03 Jan 2022 and was prescribed a topical steroid to treat her burning scalp. She stated the head burning and itching eventually resolved. after the prescribed treatment. The caller stated she was referred to her primary care physician (PCP) by the dermatologist and on or around 05 Jan 2022 had an office visit with her PCP.  The caller mentioned she has seen her PCP four or five times since the events started. She also mentioned having appointment with a rheumatologist, neurologist, dermatologist and today (01 Mar 2022) has an appointment with an endocrinologist.  Treatment also included topical steroid to treat burning scalp, OTC dandruff shampoo for head itching.   This case was linked to MOD-2022-498883 (Patient Link).