Nausea; Vomiting; Swelling at injection site; Became Hot; Diarrhea; Sever  Migraine; Full body ache and pain; Warmth at injection site; Chest Pain- Sharp and Stabbing; Severely Dehydrated; Numbness that radiates down hand; palpitations; felt as if having a heart attack; Blood Pressure Increase 130/98; This spontaneous report was received from a health care professional concerning a female patient of unknown age who received Moderna's COVID-19 Vaccine, and experienced the events Became Hot, nausea, vomiting, diarrhea, Full body ache and pain, Swelling at injection site, Warmth at injection site, Chest Pain- Sharp and Stabbing, Severely Dehydrated, Numbness that radiates down hand, palpitations, felt as if having a heart attack, Blood Pressure Increase and severe migraine  The patients' medical history was not provided. Concomitant medications list was not provided.   On 23 Dec 2020, approximately 8 hours earlier to the onset of the events, the patient received her first of two planned doses of mRNA-1273 (Lot number 032L20R) intramuscularly in the right arm for prophylaxis of COVID-19 infection.  Approximately 8 hours after the injection the patient became hot, nausea, vomiting and diarrhea, severe migraine, full body ache, pain, swelling and warmth at the site of injection. Chest pains and palpitations, pulse 130s, BP Increased 130/98, admitted into the complete cardiac workup which was negative, severely dehydrated from vomiting, IV fluid and pain meds for the migraine, GI Cocktail to numb esophagus from the vomiting. Called before to see if cardiac symptoms were reported and no one was able to assist, so she went to the emergency room. She was in the emergency room for 7 hours but was not admitted into the hospital. She continues to have a migraine, but no longer has chest sharp stabbing pain, numbing that radiates down her hand. Felt as if she was having a heart attack. They did a troponin and a repeat troponin which were negative. They did a chest x-ray, flu and COVID-19 test and they were also negative.  Treatments provided included IV fluid and pain medication for migraine, GI cocktail to numb esophagus from the vomiting.   Action taken with mRNA-1273 vaccine in response to events was not provided.  The outcome of the events Became Hot, nausea, vomiting, diarrhea, Full body ache and pain, Swelling at injection site, Warmth at injection site, Chest Pain- Sharp and Stabbing, Severely Dehydrated, Numbness that radiates down hand, palpitations, felt as if having a heart attack, Blood Pressure Increase 130/98 were reported as resolved on 26 Dec 2020. The outcome of event severe migraine was reported as not resolved.; Reporter's Comments: This case concerns a White, female patient, who experienced a non-serious unexpected event of feeling hot, diarrhea, migraine, pain, injection site warmth, chest pain, dehydration, hypoaesthesia, palpitations, feeling abnormal, blood pressure increased, and non-serious expected event of nausea and vomiting. The events occurred 1 days (8 hrs.) after first dose of mRNA-1273, lot # 026L20A.  Investigations included complete cardiac work-up (details not provided), troponin and repeat troponin, all the tests were normal; both flu and covid-19 tests were negative. Chest x-ray was normal. Treatment included IV fluids, pain meds for migraine, GI cocktail (details not provided) to numb esophagus from vomiting. Based on the current available information and temporal association between the use of the product and onset of the event a causal relationship cannot be excluded.