had hives all over the body that had an itchy, burning sensation that was responsive to touch with an active explosion of welts in that area that is like a dermatographia effect; had hives all over the body that had an itchy, burning sensation that was responsive to touch with an active explosion of welts in that area that is like a dermatographia effect; had hives all over the body that had an itchy, burning sensation that was responsive to touch with an active explosion of welts in that area that is like a dermatographia effect; had hives all over the body that had an itchy, burning sensation that was responsive to touch with an active explosion of welts in that area that is like a dermatographia effect; had hives all over the body that had an itchy, burning sensation that was responsive to touch with an active explosion of welts in that area that is like a dermatographia effect; painful and itchy; also erupt spontaneously on the body; This spontaneous case was reported by a consumer and describes the occurrence of HYPERAESTHESIA (had hives all over the body that had an itchy, burning sensation that was responsive to touch with an active explosion of welts in that area that is like a dermatographia effect), MECHANICAL URTICARIA (had hives all over the body that had an itchy, burning sensation that was responsive to touch with an active explosion of welts in that area that is like a dermatographia effect), URTICARIA (had hives all over the body that had an itchy, burning sensation that was responsive to touch with an active explosion of welts in that area that is like a dermatographia effect), PRURITUS (had hives all over the body that had an itchy, burning sensation that was responsive to touch with an active explosion of welts in that area that is like a dermatographia effect) and BURNING SENSATION (had hives all over the body that had an itchy, burning sensation that was responsive to touch with an active explosion of welts in that area that is like a dermatographia effect) in a 44-year-old male patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     No Medical History information was reported.   In March 2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 11-Apr-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 17-Dec-2021, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 27-Dec-2021, the patient experienced HYPERAESTHESIA (had hives all over the body that had an itchy, burning sensation that was responsive to touch with an active explosion of welts in that area that is like a dermatographia effect) and URTICARIA (had hives all over the body that had an itchy, burning sensation that was responsive to touch with an active explosion of welts in that area that is like a dermatographia effect). 27-Dec-2021, the patient experienced MECHANICAL URTICARIA (had hives all over the body that had an itchy, burning sensation that was responsive to touch with an active explosion of welts in that area that is like a dermatographia effect), PRURITUS (had hives all over the body that had an itchy, burning sensation that was responsive to touch with an active explosion of welts in that area that is like a dermatographia effect), BURNING SENSATION (had hives all over the body that had an itchy, burning sensation that was responsive to touch with an active explosion of welts in that area that is like a dermatographia effect), PAIN (painful and itchy) and RASH (also erupt spontaneously on the body). The patient was treated with DIPHENHYDRAMINE HYDROCHLORIDE (BENADRYL [DIPHENHYDRAMINE HYDROCHLORIDE]) for Adverse event, at an unspecified dose and frequency. At the time of the report, HYPERAESTHESIA (had hives all over the body that had an itchy, burning sensation that was responsive to touch with an active explosion of welts in that area that is like a dermatographia effect), MECHANICAL URTICARIA (had hives all over the body that had an itchy, burning sensation that was responsive to touch with an active explosion of welts in that area that is like a dermatographia effect), URTICARIA (had hives all over the body that had an itchy, burning sensation that was responsive to touch with an active explosion of welts in that area that is like a dermatographia effect), PRURITUS (had hives all over the body that had an itchy, burning sensation that was responsive to touch with an active explosion of welts in that area that is like a dermatographia effect), BURNING SENSATION (had hives all over the body that had an itchy, burning sensation that was responsive to touch with an active explosion of welts in that area that is like a dermatographia effect), PAIN (painful and itchy) and RASH (also erupt spontaneously on the body) outcome was unknown.            Concomitant product use was not provided by the reporter.    The treatment with Benadryl did not work for the patient and also the patient did not respond to antihistamine therapy.  If the patient makes a line on the arm, it will erupt with hives on that line.  The condition was worse at night for the patient, particularly at bedtime.   This case was linked to MOD-2022-439616 (Patient Link).