tested positive for Covid on 24Apr2022; tested positive for Covid on 24Apr2022; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP) from medical information team and product quality group. The reporter is the patient.  A 70-year-old male patient received BNT162b2 (BNT162B2), on 08Feb2021 as dose 1, single (Lot number: FN6201), on 01Mar2021 as dose 2, single (Lot number: EN6201), on 14Aug2021 as dose 3 (booster), single (Lot number: FC3180) and on 14Jan2022 as dose 4 (booster), single (Lot number: 33130BA) at the age of 69 years for covid-19 immunisation. The patient's relevant medical history included: "AIDS" (unspecified if ongoing), notes: AIDS had Aids for 30 years or more, viral load is at 150 last time; "Blood pressure high" (ongoing), notes: Blood pressure high controlled, diagnosed 6 or 7 years ago, not completely sure; "mild kidney issue" (unspecified if ongoing), notes: been on for 5 or 6 years splits up the doses because of a mild kidney issue. The patient's family history included: "Prediabetes" (ongoing), notes: Prediabetes Has always been pre diabetic, his father was also diabetic. Concomitant medication(s) included: LOSARTAN taken for hypertension. The following information was reported: VACCINATION FAILURE (medically significant) with onset 24Apr2022 at 08:00, outcome "unknown", COVID-19 (medically significant) with onset 24Apr2022 at 08:00, outcome "not recovered" and all described as "tested positive for Covid on 24Apr2022". The patient underwent the following laboratory tests and procedures: SARS-CoV-2 test: (24Apr2022) Positive, notes: States he first tested positive for Covid on 24Apr2022 at 8am; (02May2022) Negative, notes: States he did test negative, first on 02May2022, and then again on 03May2022 and 06May2022; (03May2022) Negative, notes: States he did test negative, first on 02May2022, and then again on 03May2022 and 06May2022; (06May2022) Negative, notes: States he did test negative, first on 02May2022, and then again on 03May2022 and 06May2022; (12May2022) Positive, notes: and tested again on 12May2022 and it was positive; (13May2022) Positive, notes: states he tested again today to make sure and he was even more positive today than he was yesterday. Therapeutic measures were taken as a result of covid-19. Clinical course: Additional information: Caller states he is calling about Paxlovid, caller began a treatment of Paxlovid in the evening of 24Apr2022 and went through the course for 5 days and states yesterday he retested positive for Covid again, wanting to know if he can do Paxlovid a second time, doctor advised not to, but he wanted to know if we had any information about a second treatment of Paxlovid Caller states he does have health is. ues that we should know about. Caller states he goes to (Name withheld) and it is a little convoluted. Called a number and someone (Name withheld) prescribed the medication, caller states he has a primary care doctor as well but there is an HIV Pharmacist he sees, states that is who he would like to be contacted if necessary, goes by "(Name withheld)" but her name is listed as (Name withheld), Pharmacist Doctor, HIV Coordinator, the chief pharmacist, states she has been his primary contact been with her for 30 years. States he first tested positive for Covid on 24Apr2022 at 8am, that is the day he started the medication. Continued the medication for 5 days and ended the doses on 29Apr2022, caller states he never felt completely better, states he even wrote a letter to primary care and Phooey that he thought maybe he had long Covid since he did not get to feeling better with the Paxlovid treatment. States he did test negative, first on 02May2022, and then again on 03May2022 and 06May2022. States he started feeling a little bit worse and tested again on 12May2022 and it was positive, states he tested again today to make sure and he was even more positive today than he was yesterday. States he uses the Health tests. States they have a control line and test line and test line changed faster than the control line, states it was darker today than yesterday, which is interesting because he states he feels better today than yesterday. Caller states he does have AIDS, has had it for 30 years or so. Caller also wants to know if Paxlovid can make HIV drugs less effective, caller states he is just wondering because he heard that somewhere and does not believe it. Caller during transfer to agent mentioned he also had 4 doses of the Pfizer Covid vaccine prior to the Paxlovid treatment.  No follow-up attempts are possible. No further information is expected.