The callers Mother passed away from Cirrhosis of the Liver and Dementia; The callers Mother passed away from Cirrhosis of the Liver and Dementia; This spontaneous case was reported by a patient family member or friend and describes the occurrence of HEPATIC CIRRHOSIS (The callers Mother passed away from Cirrhosis of the Liver and Dementia) and DEMENTIA (The callers Mother passed away from Cirrhosis of the Liver and Dementia) in an 87-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination.     Concurrent medical conditions included Dementia and Liver cirrhosis.   On 29-Jan-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 05-Mar-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 30-Aug-2021, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On an unknown date, the patient experienced HEPATIC CIRRHOSIS (The callers Mother passed away from Cirrhosis of the Liver and Dementia) (seriousness criteria death and medically significant) and DEMENTIA (The callers Mother passed away from Cirrhosis of the Liver and Dementia) (seriousness criteria death and medically significant). The reported cause of death was cirrhosis of the liver and Dementia. It is unknown if an autopsy was performed.        For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown), the reporter did not provide any causality assessments.   Concomitant medication was not provided. Treatment information was not provided.  Company comment: This is a spontaneous case concerning a 87-year-old, female patient with concurrent medical conditions of cirrhosis of the liver and dementia and with vaccine history of receiving first, second and third dose of mRNA-1273 vaccine, who experienced the unexpected serious (medically significant and death) AESI event of hepatic cirrhosis and the unexpected serious (medically significant and death) event of dementia. The events hepatic cirrhosis and dementia occurred before the patient received first, second and third dose of mRNA-1273 vaccine administration. It was reported that the patient died from cirrhosis of the liver and dementia approximately 66 days after the patient received third dose of mRNA-1273 vaccine administration. It was unknown if autopsy was performed and if the cause of death was determined by a physician. The patient's age remain confounder for the event dementia. The concurrent medical conditions of cirrhosis of the liver and dementia remain confounders for the events. The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report.   This case was linked to MOD-2022-575845.; Sender's Comments: This is a spontaneous case concerning a 87-year-old, female patient with concurrent medical conditions of cirrhosis of the liver and dementia and with vaccine history of receiving first, second and third dose of mRNA-1273 vaccine, who experienced the unexpected serious (medically significant and death) AESI event of hepatic cirrhosis and the unexpected serious (medically significant and death) event of dementia. The events hepatic cirrhosis and dementia occurred before the patient received first, second and third dose of mRNA-1273 vaccine administration. It was reported that the patient died from cirrhosis of the liver and dementia approximately 66 days after the patient received third dose of mRNA-1273 vaccine administration. It was unknown if autopsy was performed and if the cause of death was determined by a physician. The patient's age remain confounder for the event dementia. The concurrent medical conditions of cirrhosis of the liver and dementia remain confounders for the events. The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report.; Reported Cause(s) of Death: Cirrhosis of the Liver; Dementia