titers before the vaccine and they were 4400, after the vaccine they were 275; titers before the vaccine and they were 4400, after the vaccine they were 275; vaccine put his Lupus in remission; Low grade fever; feel he had sickness; Lethargic; felt he had a little cold; feeling achy; felt Bleh; This is a spontaneous report from a contactable consumer (patient). A 49-year-old male patient received bnt162b2 (BNT162B2 reported as PFIZER COVID-19 VACCINE), dose 2 at vaccination age of 49-year-old on 31Mar2021 15:00 (Lot Number: EP6755) as 2nd dose, single dose; and dose 1 on 10Mar2021 (Lot Number: EN6206) as 1st dose, single dose, both via an unspecified route of administration for covid-19 immunisation. Medical history included ongoing systemic lupus erythematosus (diagnosed lupus diagnosed 15 years ago [2006]), antiphospholipid syndrome which is also called hughes syndrome and he was diagnosed 15 years ago [2006] (his numbers are so high that University came over and taken his blood samples as he is a unique case. It is on the national order of rare diseases), ongoing overweight, tachycardia, thyroid under-productive, ongoing neuropathy peripheral, lupus anticoagulant, ministrokes and 2 massive strokes that affected his left side. It was reported that his blood was clotting in his veins and he was having mini strokes and then he had 2 massive strokes. He has a lot of joint and RA factor in his blood. In his back, he had L4-5 disc removed in January and he has stiffness and pain from Lupus. He mentioned that his family has many autoimmune disorders. His son has the worst case of Grave's disease. Concomitant medications included gabapentin (GABAPENTIN) taken for neuropathy peripheral from Feb2021 (reported as taken a month before the first vaccine) to unknown date; iron oxides taken for an unspecified indication from an unknown date in 2021 (reported as few months before the first vaccine) to an unknown date; and propranolol to keep away tachycardia. The patient did not receive other vaccines on the day of covid-19 vaccination. The patient narrated that his plasma was high that he sells his plasma and they make test kits out of his antiphospholipid titers and he never runs under 4,000 on any of those. The patient mentioned that he has been 15 years they have been checking his titers. They checked his titers before the which was 4400 and after the vaccine (07Apr2021), they were 275. The patient mentioned that he has taken the 2 shots and the vaccine put his Lupus in remission (07Apr2021). The patient added that it knocked his titers for anticardiolipin IgM, and alphaglycoproteins IgM down (2021). The patient stated that it has been going on with him for 15 years, and nothing else has brought them down like that. The only new medications he started this year (2021) were Gabapentin and Iron pill so nothing else could have affected his titers except for the Covid vaccine. They checked his titers again (unknown result) so they could do his draws, they could not believe it. The patient further stated that he got a hold of the CDC and health department and they are supposed to be getting ahold of Pfizer. The patient stated that this is a good thing, the vaccine basically put his Lupus in remission and mentioned that he does not know the correlation. The patient has had no rashes, boils, hives, his joint pain has greatly decreased. The vaccine is suppressing all of those antiphospholipids that cause all of those problems. He does not know how close to a cure for Lupus the vaccine is, but this happened a week after the second shot. This has never happened before, so the patient thinks there has to be something there and Pfizer may have stumbled onto something amazing. The patient stated that every medicine he has been on for Lupus, and nothing has controlled his Lupus and Antiphospholipid syndrome. He further added that he has connective tissue pain, it is still there but not near as much as it was and his back was messed up and now that the Lupus is under control his back does not have real pain, just discomfort. In his back, he had L4-5 disc removed in January and he has stiffness and pain from Lupus and now it is not anywhere near as bad. He mentioned that after that it seems like once they got his results, they could not believe it. He has never been turned down for draws before and this was the first time that it was normal. He further mentioned that it is as if the Lupus has gone away. He stated that he had very little side effects from shots which included he felt Bleh and had a low-grade fever on 01Apr2021. The patient added that after the first shot, he had no problems. After the second on 01Apr2021 to 02Apr2021, he felt like he had a little cold or sickness, achy and he was lethargic for a couple of days, and then after that, he was normal again. The patient stated that he has not been having the flare ups that he usually has with Lupus. The inhibitors are what causes his Lupus and APLS which he has had them for 15 years, with no relief. The first time he has relief, was getting a vaccine for a Covid strain. The patient did not received treatment for the adverse events. The patient contacted the main guy that makes the test panel kits, and all they can think of is there is something in the vaccine that is suppressing his immune system. He does not know how long it will last but so far it has lasted about 4 weeks. He feels way better than before, and he will know if it wears off because his symptoms will start. The adverse events did not result in emergency room or physician office visit. The outcome of the events 'titers before the vaccine and they were 4400, after the vaccine they were 275' and 'vaccine put his Lupus in remission' were unknown while the outcome of the other events was recovered on 02Apr2021.   No follow-up attempts are needed. No further information expected.