The patient's PSA was 6 at the beginning of 2021/His PSA retested and it now resulted at 17.7, up 6 times/Two more retests were done and they resulted 14.9 and 18; This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP) from medical information team.  A 45 year-old male patient received bnt162b2 (BNT162B2), administered in arm left, administration date 11Sep2021 (Batch/Lot number: unknown) as dose 2, single for covid-19 immunisation. Relevant medical history included: "Type 2 diabetes mellitus", start date: 2009 (unspecified if ongoing), notes: Diagnosed in 2009; "prostate cancer" (unspecified if ongoing). The patient's concomitant medications were not reported. Past drug history included: Erythromycin. Vaccination history included: Bnt162b2 (dose 1, single), administration date: 11Aug2021, for COVID-19 immunization. The following information was reported: PROSTATIC SPECIFIC ANTIGEN INCREASED (medically significant) with onset 21Oct2021, outcome "unknown", described as "The patient's PSA was 6 at the beginning of 2021/His PSA retested and it now resulted at 17.7, up 6 times/Two more retests were done and they resulted 14.9 and 18". The event "the patient's psa was 6 at the beginning of 2021/his psa retested and it now resulted at 17.7, up 6 times/two more retests were done and they resulted 14.9 and 18" was evaluated at the physician office visit and emergency room visit. The patient underwent the following laboratory tests and procedures: prostatic specific antigen: (unspecified date) 14.9; (unspecified date) 18; (2021) 6; (21Oct2021) 17.7. The reporter stated that a patient who was referred to him his PSA levels have gone up 3 times since receiving his second dose of the Pfizer BioNtech covid 19 vaccine. It was reported that the patient his first dose of Pfizer BioNtech covid 19 vaccine on 11Aug2021 and his second dose about a month later on 11Sep2021. The patient had his PSA levels drawn at the start of 2021 and level was 6. Patient also took drugs that suppresses symptoms, erythromycin, on a regular basis for the last year. Patient wanted to get his PSA retested and it now resulted at 17.7, up 6 times. Two more retests were done and they resulted 14.9 and 18. Another doctor has recommended he have a biopsy done however the patient doesn't feel bad. The reporter asked if there are any information on elevated PSA levels after vaccination, specifically are they surface protein levels or a true increase. The reporter stated that a patient that was just referred to him after his PSA levels went up after receiving the vaccine. The patient's PSA was 6 at the beginning of 2021. He had his 1st dose of the vaccine on 11Aug2021, then received the 2nd dose on 11Sep2021, and had blood drawn on 21Oct2021 and his PSA was 17.7. The patient was referred to him after he got upset that his PSA level has gone up 3 times in one year. The reporter requested that the patient get a CBC. The problem is that the doctor that ordered the PSA test wanted to do a biopsy which is painful and bloody and could lead to surgery. The question is, is this PSA a false number or a real number? If it's a real number, then this will lead to major problems for Pfizer because it means that the vaccine has made the prostate cancer more aggressive and the prostate cancer could kill him if it becomes aggressive. The patient was told that he needs to have a biopsy done because they couldn't tell the difference between the surface protein and the PSA.   The lot number for bnt162b2 was not provided and will be requested during follow up.; Sender's Comments: Linked Report(s) : US-PFIZER INC-202200031522 same reporter/product/event, different patient