GUILLAIN-BARRE SYNDROME; STRESS; ENTIRE BODY SHAKES; HEADACHE; PALPITATIONS; EXTREME CHILLS; DEEP MUSCLE PAIN; HIGH TEMPERATURE; This spontaneous report received from a patient concerned a 59 year old female. The patient's height, and weight were not reported. The patient's past medical history included: covid-19 infection(DEC-2020), and concurrent conditions included: wolff-parkinson-white syndrome, heart palpitations due to malformed heart blood vessel, alcohol user, non-smoker, and seizure and other pre-existing medical conditions included: Patient did not have any drug abuse or illicit drug usage. The patient experienced drug allergy when treated with diazepam for seizures. The patient received covid-19 vaccine ad26.cov2.s (suspension for injection, route of admin not reported, batch number: 212A21A, and expiry: 21-DEC-2021) dose was not reported, 1 total, administered on 23-SEP-2021 13:00 at right arm for prophylactic vaccination. No concomitant medications were reported.  On 24-SEP-2021 (midnight), patient experienced high temperature (about 102 F), extreme chills, deep muscle pain, tingling from neck to lower back to extremities. By 4:00 am, patient was paralyzed. During paralysis, she did not lose feeling, but she was unable to move. Patient stated that she was terrified and she refused to go to the hospital. Her husband did range of motion in all of her extremities. Within 5 hours, with husband's assistance, patient was able to get on a walker and shuffle. The next day, the patient had shortness of breath and palpitations and she called the family doctor and made an appointment On 29-SEP-2021, patient was still on walker, and her vision was affected. Patient could not see clearly, and had headaches. The patient described it as a headache, not a migraine. The family doctor sent the patient to the emergency room was reported. The patient underwent through computerized tomogram scan of brain which ruled out stroke, cerebral spinal fluid with lumbar puncture 69 protein. A lumbar puncture diagnosed her with Guillain-Barre syndrome and on 29-SEP-2021, she was admitted to the hospital to the neuro floor. A magnetic resonance imaging of the brain and the entire spinal column was performed. Treatment with Intravenous immunoglobulins of 5 infusions. On 05-OCT-2021 the patient was discharged after 7 days was reported. At the time of reporting on 18-OCT-2021, the patient was able to walk 0.25 miles, but then got tired. The patient was still having tingling on the left side, in particular left foot and left hand. The patient was still getting a headache that would get up at night, but medication was not needed. Her vision was back. It was reported that the patient does not understand, if she got stressed, her entire body shakes for 15 mins. She could not get upset. The patient felt embarrassed of losing control of her body was reported. The action taken with covid-19 vaccine ad26.cov2.s was not applicable. The patient recovered from palpitations on 01-OCT-2021, and extreme chills, and high temperature on 24-SEP-2021, was recovering from headache, and guillain-barre syndrome, had not recovered from deep muscle pain, and the outcome of stress and entire body shakes was not reported. This report was serious (Hospitalization Caused / Prolonged).; Sender's Comments: V0: 20211033707-covid-19 vaccine ad26.cov2.s-Guillain-Barre syndrome. This event(s) is labeled per RSI and is therefore considered potentially related.