Flare up of arthritis pain after third shot/Never felt arthritis pain this bad after third dose; This spontaneous case was reported by a consumer and describes the occurrence of ARTHRITIS (Flare up of arthritis pain after third shot/Never felt arthritis pain this bad after third dose) in a 56-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 026D21A, 020B21A and 024M20A) for COVID-19 vaccination.     Previously administered products included for Arthritis: Cimzia (Took after second vaccine and it worked for 6 weeks only) in 2021; for Product used for unknown indication: ENBREL (Continued till 12 weeks and it did not work. So stopped it 2 weeks before third dose.) in July 2021 and Humaria (Medication stopped working right before first vaccine). Past adverse reactions to the above products included No adverse event with Cimzia, ENBREL and Humaria. Concurrent medical conditions included Arthritis (Auto-immune disease).   On 07-Mar-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 06-Apr-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 25-Oct-2021, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 25-Oct-2021,  after starting mRNA-1273 (Moderna COVID-19 Vaccine), the patient experienced ARTHRITIS (Flare up of arthritis pain after third shot/Never felt arthritis pain this bad after third dose). The patient was treated with ABATACEPT (ORENCIA) for Adverse event, at a dose of 6 dosage form. At the time of the report, ARTHRITIS (Flare up of arthritis pain after third shot/Never felt arthritis pain this bad after third dose) outcome was unknown.            Company Comment-This case concerns  56 years old female patient with relevant medical history of ARTHRITIS treated in the past with adalimumab, cetrolizumab and etanercept , who experienced the   unexpected AESI of ARTHRITIS (Flare up of arthritis pain). The events occurred   one day after the third dose  of mRNA-1273 vaccine. The similar reactions occurred after the first and second dose of mRNA-1273 which   were not resolved completely even after the treatment. The Re challenge was not applicable ,  as the event occurred after the third dose.The benefit-risk relationship of mRNA-1273Vaccine is not affected by this report.  Patient had never COVID-19.  No concomitant medication was reported by reporter. All the historical drug and treatment drug patient took were ineffective   This case was linked to MOD-2021-407194, MOD-2021-407412 (Patient Link).; Sender's Comments: This case concerns  56 years old female patient with relevant medical history of ARTHRITIS treated in the past with adalimumab, cetrolizumab and etanercept , who experienced the   unexpected AESI of ARTHRITIS (Flare up of arthritis pain). The events occurred   one day after the third dose  of mRNA-1273 vaccine. The similar reactions occurred after the first and second dose of mRNA-1273 which   were not resolved completely even after the treatment. The Re challenge was not applicable ,  as the event occurred after the third dose.The benefit-risk relationship of mRNA-1273Vaccine is not affected by this report.