Bone on bone in knee; Muscle cramps; Swelling in hands/knees/wrists; Cough; COVID-19 vaccines did enhance inflammation for about two to three days after each one; Swelling in hands; Fever; Pain in hands/wrists; Tired; This spontaneous case was reported by a consumer and describes the occurrence of OSTEOARTHRITIS (Bone on bone in knee), MUSCLE SPASMS (Muscle cramps), JOINT SWELLING (Swelling in hands/knees/wrists), COUGH (Cough) and INFLAMMATION (COVID-19 vaccines did enhance inflammation for about two to three days after each one) in a 56-year-old male patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.    Co-suspect product included non-company product ADALIMUMAB (HUMIRA) solution for injection for Rheumatoid arthritis.    No Medical History information was reported.   On 18-Jan-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. In February 2021, ADALIMUMAB (HUMIRA) (Subcutaneous) dosage was changed to UNK, Citrate free. On 15-Feb-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. On an unknown date, the patient started ADALIMUMAB (HUMIRA) (Subcutaneous) at an unspecified dose. On an unknown date, the patient experienced OSTEOARTHRITIS (Bone on bone in knee), MUSCLE SPASMS (Muscle cramps), JOINT SWELLING (Swelling in hands/knees/wrists), COUGH (Cough), INFLAMMATION (COVID-19 vaccines did enhance inflammation for about two to three days after each one), PERIPHERAL SWELLING (Swelling in hands), PYREXIA (Fever), ARTHRALGIA (Pain in hands/wrists) and FATIGUE (Tired). At the time of the report, OSTEOARTHRITIS (Bone on bone in knee) had not resolved, MUSCLE SPASMS (Muscle cramps), COUGH (Cough), INFLAMMATION (COVID-19 vaccines did enhance inflammation for about two to three days after each one), PYREXIA (Fever) and FATIGUE (Tired) outcome was unknown and JOINT SWELLING (Swelling in hands/knees/wrists), PERIPHERAL SWELLING (Swelling in hands) and ARTHRALGIA (Pain in hands/wrists) was resolving.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): In October 2020, SARS-CoV-2 test: (Positive) Positive. In November 2020, SARS-CoV-2 test: (Positive) Positive. In February 2021, SARS-CoV-2 test: (Negative) Negative.         This case was identified as part of a retrospective clean-up activity where certain emails received in the Moderna mailbox were missed to be booked-in.  No concomitant medication was reported.  It was unknown if patient was enrolled in a COVID-19 Vaccine Trial.  No treatment medication was reported.  The reporter's causality for the event(s) of covid-19 positive, swelling in hands/knees/wrists unknown onset, pain in hands/wrists and swelling in hands/knees/wrists unknown onset with Humira(adalimumab) was a reasonable possibility. The reporter's causality for the event(s) of bone on bone in knee, after booster for covid-19 vaccine/was very achy in joints and exhausted onset in September 2021, after booster for covid-19 vaccine/was very achy in joints and exhausted onset in September 2021 and covid-19 vaccines did enhance inflammation for about two to three days after each one with Humira(adalimumab) was no reasonable possibility. The reporter's causality for the event(s) of tired, cough, fever and muscle cramps was not provided.   This case was linked to MOD-2021-624987 (Patient Link).   Most recent FOLLOW-UP information incorporated above includes: On 02-Nov-2021: Significant Follow Up Appended (Live FU) _Suspect drug information and narrative description updated.