night sweats; She was tested further for each autoimmune condition and it showed up as a factor for Lupus; Rheumatoid Arthritis; HIV screening on 09Feb2022 came back reactive/They did a second one on 15Feb2022 that was also reactive/on 16Feb2022 thy did a HIV 1 RNA Ultra PCR and it came back as not detected; CK was elevated in Aug2021; So sick after each vaccine/ She was really sick after the second one; She could hardly get out of bed, barely go to the bathroom; weak; sick with horrible diarrhea; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP). The reporter is the patient.  A 45-year-old female patient received BNT162b2 (BNT162B2), on 17Jul2021 as dose 2, single (Lot number: EW0186) at the age of 45 years, in left arm for covid-19 immunisation. The patient's relevant medical history included: "COVID-19", start date: Jan2021 (unspecified if ongoing), notes: Had mild COVID with a bad headache. Concomitant medication(s) included: VITAMIN B 12 [VITAMIN B12 NOS]. Vaccination history included: BNT162b2 (Dose 1, Lot Number: EW175 , anatomical location: left arm), administration date: 22Jun2021, when the patient was 45-year-old, for Covid-19 Immunization, reaction(s): "she got so sick", "Chest pain", "fatigue", "difficulty going up and down the stairs". The following information was reported: BEDRIDDEN (non-serious) with onset Jul2021, outcome "unknown", described as "She could hardly get out of bed, barely go to the bathroom"; ILLNESS (non-serious) with onset Jul2021, outcome "unknown", described as "So sick after each vaccine/ She was really sick after the second one"; DIARRHOEA (non-serious) with onset Jul2021, outcome "unknown", described as "sick with horrible diarrhea"; ASTHENIA (non-serious) with onset Jul2021, outcome "unknown", described as "weak"; BLOOD CREATINE PHOSPHOKINASE INCREASED (non-serious) with onset Aug2021, outcome "unknown", described as "CK was elevated in Aug2021"; HIV ANTIGEN POSITIVE (non-serious) with onset 09Feb2022, outcome "unknown", described as "HIV screening on 09Feb2022 came back reactive/They did a second one on 15Feb2022 that was also reactive/on 16Feb2022 thy did a HIV 1 RNA Ultra PCR and it came back as not detected"; NIGHT SWEATS (non-serious), outcome "unknown"; SYSTEMIC LUPUS ERYTHEMATOSUS (medically significant), outcome "unknown", described as "She was tested further for each autoimmune condition and it showed up as a factor for Lupus"; RHEUMATOID ARTHRITIS (medically significant), outcome "unknown". The events "so sick after each vaccine/ she was really sick after the second one", "she could hardly get out of bed, barely go to the bathroom", "weak", "sick with horrible diarrhea", "night sweats", "hiv screening on 09feb2022 came back reactive/they did a second one on 15feb2022 that was also reactive/on 16feb2022 thy did a hiv 1 rna ultra pcr and it came back as not detected", "she was tested further for each autoimmune condition and it showed up as a factor for lupus", "rheumatoid arthritis" and "ck was elevated in aug2021" required physician office visit. The patient underwent the following laboratory tests and procedures: Antinuclear antibody: (unspecified date) Negative; (unspecified date) Positive; Blood creatine phosphokinase: (Aug2021) Elevated; HIV antigen: (09Feb2022) Reactive; (15Feb2022) Reactive; tested further for each autoimmune condition: (unspecified date) it showed up as a factor for Lupus and Rheumatoid, notes: it showed up as a factor for Lupus and Rheumatoid Arthritis; Polymerase chain reaction: (16Feb2022) Not Detected. Therapeutic measures were taken as a result of illness, bedridden, asthenia, diarrhoea.  Additional information: Patient stated that she was sick after each of the vaccines. She was really sick after the second one. With the first one she had chest pain, fatigue, difficulty going up and down the stairs.  With the second one she got the worst symptoms probably 8-12 hours after the vaccine.  She could hardly get out of bed, barely go to the bathroom, she was weak and sick with horrible diarrhea. Caller said she had to have steroids for the symptoms. Caller stated that she was having night sweats also. Stated that her insurance has a routine HIV screening. Caller says that her HIV screening on 09Feb2022 came back reactive. They did a second one on 15Feb2022 that was also reactive.  Caller stated then on 16Feb2022 thy did a HIV 1 RNA Ultra PCR and it came back as not detected. Caller needs her glasses to read her laptop screen. Stated she had a positive ANA come back also. She was tested further for each autoimmune condition and it showed up as a factor for Lupus and Rheumatoid Arthritis.  States she has no further evidence of those disease processes.  Caller mentions that she had another ANA in Apr and it was negative. States she didn't know it could go back and forth. Caller stated that her and her girls had their vaccines at the same time. Stated that her second daughter had trouble with the second vaccine and also does not want to get the booster. Caller denies any other medications or medical conditions relevant to these events. Caller mentions that her lab work is usually always good.  States that her CK was elevated in Aug2021.  States that her referral to # required a lot of labs to be done. They did troponin P miratic peptides that was normal.  Caller also states they have been giving her monthly B12 injections. Patient required a visit to emergency room. Prior Vaccinations (within 4 weeks) patient did not take any other vaccinations within four weeks prior to the first administration date of the suspect vaccine.  No follow-up attempts are possible. No further information is expected.