Rheumatoid arthritis sometimes flares up and gets sore; Soreness and achiness in right shoulder and arm / felt sore and achy; Soreness and achiness in right shoulder and arm / felt sore and achy; Patient stated it was weird; Inflamed shoulder/during night it was very bad; Lower left eyelid which is inverted, it is bothering her / have to release the muscle; This case was reported by a consumer via other manufacturer and described the occurrence of rheumatoid arthritis flare up in a 78-year-old female patient who received Herpes zoster (Shingrix) for prophylaxis.   Concurrent medical conditions included rheumatoid arthritis (arthritis in right shoulder and arm gets inflamed and sore which was diagnosed in late 2019), autoimmune deficiency syndrome (diagnosed in late 2019) and shoulder arthritis (arthritis in right shoulder).   On an unknown date, the patient received Shingrix. On an unknown date, less than 2 years after receiving Shingrix, the patient experienced rheumatoid arthritis flare up (serious criteria GSK medically significant), pain in arm, shoulder pain, weird feeling, flare up of arthritis and entropion. On an unknown date, the outcome of the rheumatoid arthritis flare up and weird feeling were unknown and the outcome of the pain in arm, shoulder pain and flare up of arthritis were recovered/resolved and the outcome of the entropion was not recovered/not resolved.   It was unknown if the reporter considered the rheumatoid arthritis flare up, pain in arm, shoulder pain, weird feeling, flare up of arthritis and entropion to be related to Shingrix.  Additional details were provided as follows: The reporter was the patient.  The age at vaccination was not reported but it could be 77 or 78 years. The rheumatoid arthritis sometimes flares up and gets sore. The routine lab work was done on 2nd February 2021 which had nothing to do with these vaccinations and no other relevant tests were performed. The patient had received Shingrix vaccine in the left arm and experienced soreness and achiness in right shoulder and arm a year ago. The patient received the Pfizer Covid 19 vaccine (batch number EN6201) on 17th February 2021 10:15 at left upper arm intramuscularly and few hours later her right shoulder and right arm felt sore and achy. The reporter stated that it was weird. It hurt on lifting her arm up high and had an inflamed shoulder. The patient also had an inflamed shoulder previously which was pretty good lately but flared up after the vaccine, it was very bad during the night. The reporter was wondering if there was a relationship with the Covid 19 vaccine because she felt like she got the Covid 19 vaccine in the right arm and was asking if she was reacting to the medication. The patient has been scheduled to get the botox injection a week after the reporting date for lower left eyelid which was inverted as it was bothering her.They had to release the muscle through the botox injection.She had called CDC to find out if the botox injection would be effected by the vaccine. The patient's primary care physician asked her to wait a month while on the contrary the opthalmologist said it was okay to get the Covid 19 vaccine. The patient thought she heard something about not mixing botox with the vaccine. No treatment was taken for right shoulder. The patient was not hospitalized or did not visit an emergency room or physician's office. The reporter consented to follow-up but declines to provide health care professional's details.