Extreme fatigue; extreme lethargy started approx 2 weeks ago; Redness of hands, face; Scabing of face and hands; loss of appetite; pain in joints; feel a burning on ears, forearms and hands; worsening to sleeping around the clock for nearly 2 days; This serious case was reported by a consumer and described the occurrence of erythema in a 78-year-old male patient who received HAB (Hepatitis A/hepatitis B vaccine) for prophylaxis.   Concurrent medical conditions included chronic obstructive pulmonary disease, diabetes, atrial fibrillation and vascular dementia.   On 29-JUN-2023, the patient received Hepatitis A/hepatitis B vaccine. On 29-JUN-2023, less than a day after receiving Hepatitis A/hepatitis B vaccine, the patient experienced erythema (Verbatim: Redness of hands, face) (serious criteria other: serious as per reporter), scab (Verbatim: Scabing of face and hands) (serious criteria other: serious as per reporter), appetite lost (Verbatim: loss of appetite) (serious criteria other: serious as per reporter), joint pain (Verbatim: pain in joints) (serious criteria other: serious as per reporter) and burning sensation (Verbatim: feel a burning on ears, forearms and hands). In JUL-2023, the patient experienced lethargy (Verbatim: extreme lethargy started approx 2 weeks ago) and sleep disorder (Verbatim: worsening to sleeping around the clock for nearly 2 days). On an unknown date, the patient experienced fatigue (Verbatim: Extreme fatigue) (serious criteria other: serious as per reporter). The patient was treated with ANALGESIC, NOS (PAIN RELIEVER (DRUG NAME UNKNOWN)), prednisone, non-drug therapy (Ice Pack (No Medication)), ibuprofen, non-drug therapy (Cold Pack) and naproxen (Aleve). In JUL-2023, the outcome of the sleep disorder was resolved (duration 2 days). The outcome of the erythema, scab, fatigue, appetite lost and joint pain were not resolved and the outcome of the burning sensation was not reported and the outcome of the lethargy was unknown.   It was unknown if the reporter considered the erythema, scab, fatigue, appetite lost, joint pain, burning sensation, lethargy and sleep disorder to be related to Hepatitis A/hepatitis B vaccine.     It was unknown if the company considered the erythema, scab, fatigue, appetite lost, joint pain, burning sensation, lethargy and sleep disorder to be related to Hepatitis A/hepatitis B vaccine.   Additional Information: GSK receipt date: 21-Jul-2023 The patient had experienced redness of hands and face, scabbing of face and hands, extreme fatigue, loss of appetite, pain in joints. Within 3 hours after vaccination, the patient started to feel a burning on ears, forearms and hands. The patient stated extreme lethargy started approximately 2 weeks ago, worsening to sleeping around the clock for nearly 2 days.  The reporter seriousness for redness of hands and face, scabbing of face and hands, extreme fatigue, loss of appetite, pain in joints was intervention required. The patient had been seen at urgent care, suggested and cold compresses, followed by emergency visit the next day, administered pain reliever injection suggested continue cold packs and aleve.  Two days later primary care suggested prednisone, ice packs and ibuprofen 600 mg every 6 hours. It was now 21st July 2023 and little to no relief.  The patient stated multiple drugs treating chronic obstructive pulmonary disease, diabetes, atrial fibrillation and vascular dementia. The patient stated that help please. The reporter consented to follow-up.