left arm was bruised, swollen and inflamed also at the injection site; left arm was bruised, swollen and inflamed also at the injection site; left arm was bruised, swollen and inflamed also at the injection site; Sick; scratchy throat; Allergic reaction; rash on chest/ over the next 24 hours the rash spread to her neck and then her mouth 24 hours later; hives on chest; itching; rash spread to her neck and then her mouth 24 hours later; her chest was still blotchy and red for four days/redness/ blotchy; left arm was in pain for a week at the injection site; This case was reported by a consumer via call center representative and described the occurrence of injection site inflammation in a 54-year-old female patient who received Herpes zoster (Shingrix) for prophylaxis.   The patient's past medical history included red blotches (area starts out blotchy on neck and goes to arms, chest was blotchy and red) and throat irritation (scratchy throat). Previously experienced adverse reactions included allergic reaction to bee sting (Family History) and anaphylaxis (Family History). Previously administered products included Penicillin with an associated reaction of rash macular (received on an unknown date and after shot, the area started out blotchy on her neck and goes to her arms and then a scratchy throat and she just knew something was not right) and Morphine with an associated reaction of rash macular (similar reaction like penicillin). Concurrent medical conditions included drug allergy (to Penicillin and Morphine).   On 28th November 2020, the patient received the 1st dose of Shingrix (intramuscular). In November 2020, 8 hrs after receiving Shingrix, the patient experienced rash, hives, pruritus, rash mouth and erythromacular rash. On an unknown date, the patient experienced injection site inflammation, injection site swelling, injection site bruising, injection site pain, sickness, throat irritation and allergic reaction. The patient was treated with antihistamine. On an unknown date, the outcome of the injection site inflammation, injection site swelling, injection site bruising, injection site pain, rash, hives, pruritus, rash mouth and erythromacular rash were recovered/resolved and the outcome of the sickness, throat irritation and allergic reaction were unknown.   It was unknown if the reporter considered the injection site inflammation, injection site swelling, injection site bruising, injection site pain, rash, hives, pruritus, rash mouth, erythromacular rash, sickness, throat irritation and allergic reaction to be related to Shingrix.  Additional details were provided as follows: The patient reported for herself.  The patient received her first dose of Shingrix and she went home and eight hours later she developed a rash and hives on her chest and over the next 24 hours the rash spread to her neck and then her mouth 24 hours later.  The patient had itching and her left arm was in pain for a week at the injection site.  The patient's left arm was bruised, swollen and inflamed also at the injection site. The patient was told by her pharmacy to take an antihistamine which she did and it took 3-4 days for her symptoms to resolve.  The patient had a similar reaction in the past to penicillin and morphine where the area started out blotchy on her neck and went to her arms and then a scratchy throat and she just knew something wasn't right. It took four doses of antihistamine to stop the reaction and her chest was still blotchy and red for four days after. Her symptoms had resolved by the time of reporitng.  The reporter consented to follow up.