Lyme and ME/CFS symptoms have been aggravated after receiving two Pfizer Covid 19 vaccines and one booster shot; Lyme and ME/CFS symptoms have been aggravated after receiving two Pfizer Covid 19 vaccines and one booster shot; Lyme and ME/CFS symptoms have been aggravated after receiving two Pfizer Covid 19 vaccines and one booster shot; These symptoms also worsened after being vaccinated: TMJ arthritis, degenerative disc disease (neuropathy in my right foot) and arthritis in my thumbs and fingers, and shoulders; lost 30% hearing in my hearing ear; symptoms aggravated/worsened after being vaccinated; arm soreness; significant increase in my anxiety and depression; more frequent crashes/PEM (post exertional malaise); These symptoms also worsened after being vaccinated: TMJ arthritis, degenerative disc disease (neuropathy in my right foot) and arthritis in my thumbs and fingers, and shoulders; These symptoms also worsened after being vaccinated: TMJ arthritis, degenerative disc disease (neuropathy in my right foot) and arthritis in my thumbs and fingers, and shoulders; tinnitus has increased in my non-hearing ear; Ability to care for myself has been significantly diminished; stamina; brain fog; This is a spontaneous report received from contactable reporter (Consumer or other non HCP). The reporter is the patient.  A female patient received BNT162b2 (BNT162B2), on 17Feb2021 as dose 2, single (Batch/Lot number: unknown) for COVID-19 immunisation. The patient's relevant medical history included: "CMV", start date: 2003 (unspecified if ongoing); "myalgic encephalomyelitis", start date: 2005 (ongoing), notes: muscle weakness; "Chronic Fatigue syndrome", start date: 2005 (ongoing), notes: muscle weakness; "Lyme disease", start date: 2007 (ongoing), notes: muscle weakness; "Epstein-Barr" (unspecified if ongoing), notes: as a teenager; "sensory neurological deafness", start date: 2009 (unspecified if ongoing), notes: right ear; "muscle weakness" (unspecified if ongoing); "SSDI" (unspecified if ongoing). The patient's concomitant medications were not reported. Vaccination history included: BNT162b2 (DOSE 1), administration date: 27Jan2021, for COVID-19 Immunization, reactions: "Lyme and ME/CFS symptoms have been aggravated after receiving two Pfizer Covid 19 vaccines and one booster shot", "lost 30% hearing in my hearing ear", "arm soreness", "significant increase in my anxiety and depression", "more frequent crashes/PEM (post exertional malaise)", "These symptoms also worsened after being vaccinated: TMJ arthritis, degenerative disc disease (neuropathy in my right foot) and arthritis in my thumbs and fingers and shoulders", "tinnitus has increased in my non-hearing ear", "ability to care for myself has been significantly diminished", "brain fog". The following information was reported: LYME DISEASE (medically significant), POST VIRAL FATIGUE SYNDROME (medically significant), CHRONIC FATIGUE SYNDROME (medically significant), outcome "unknown" and all described as "Lyme and ME/CFS symptoms have been aggravated after receiving two Pfizer Covid 19 vaccines and one booster shot"; NEUROPATHY PERIPHERAL (medically significant), ARTHRITIS (non-serious), INTERVERTEBRAL DISC DEGENERATION (non-serious), outcome "unknown" and all described as "These symptoms also worsened after being vaccinated: TMJ arthritis, degenerative disc disease (neuropathy in my right foot) and arthritis in my thumbs and fingers, and shoulders"; HYPOACUSIS (medically significant), outcome "unknown", described as "lost 30% hearing in my hearing ear"; CONDITION AGGRAVATED (medically significant), outcome "unknown", described as "symptoms aggravated/worsened after being vaccinated"; PAIN IN EXTREMITY (non-serious), outcome "unknown", described as "arm soreness"; DEPRESSION (non-serious), outcome "recovering", described as "significant increase in my anxiety and depression"; MALAISE (non-serious), outcome "unknown", described as "more frequent crashes/PEM (post exertional malaise)"; TINNITUS (non-serious), outcome "unknown", described as "tinnitus has increased in my non-hearing ear"; LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (non-serious), outcome "recovering", described as "Ability to care for myself has been significantly diminished; stamina"; FEELING ABNORMAL (non-serious), outcome "recovering", described as "brain fog". Therapeutic measures were taken as a result of hypoacusis, depression, loss of personal independence in daily activities, feeling abnormal.  Clinical course: The patient provided a long history of chronic conditions that she attributed to various causes (eg. Lyme disease, myalgic encephalomyelitis/Chronic Fatigue syndrome, CMV infection) that she now claims have been exacerbated after receiving the Pfizer vaccine. Her many reports, attributions, and the preexisting symptoms cloud interpretation. Her Lyme and ME/CFS symptoms have been aggravated after receiving two Pfizer COVID-19 vaccines and one booster shot. The first vaccine on 17Jan2021, the second 27Feb2021 with the booster following. In 2003, she contracted CMV (cytomegalovirus) which led to the diagnosis of ME/CFS in 2005. She was also diagnosed with Lyme disease in 2007, which may or may not relate to about she had of Epstein-Barr as a teenager. She attributed the causation/worsening of arthritic condition to Lyme. In 2009, she developed sudden sensory neurological deafness in her right ear, she believed that condition and her muscle weakness can be attributed to either Lyme or ME/CFS. The symptoms had been debilitating enough that by 2009, she began receiving SSDI. She had supplemented that income with substitute teaching. Unfortunately, she could manage teaching only one day a week followed by a "recovery day" or two. Following her first Pfizer vaccine on 27Jan2021 and her second shot on 17Feb2021, she did not initially notice any significant symptoms other than arm soreness, although she did experience as significant increase in her anxiety and depression. As the time went on, however, she began noticing that the symptoms of both illnesses were worsening (Some seen to be Lyme specific, others common to both Lyme and ME/CFS). In addition, she began experiencing more frequent crashes/PEM (post exertional malaise), the debilitating effect of any type of over exertion related to her ME/CFS. They were debilitating enough that she needed to stop working as a sub almost entirely - only about five days the entire school year. The lack of income had forced her to tap what little savings she had set aside for retirement to supplement her payments (plus charges on credit cards) to maintain a simple lifestyle. These symptoms also worsened after being vaccinated: TMJ arthritis, degenerative disc disease (neuropathy in her right foot) and arthritis in her thumbs and fingers and shoulders. The tinnitus had increased in her non-hearing ear, and she had lost 30% hearing in her hearing ear, which required her to get a hearing aid. At times her ability to care for herself had been significantly diminished. On some occasions, she was not able to drive and get medication or go to the grocery store. As a result, she had to cancel various appointments, a visit with her son in another state and many get to gather with friends. She still can't plan with any degree of certainly. She also had to stop her volunteer work with favorite non-profit since the crashes came too often and were too intense. She began LDN (low dose naltrexone) in the middle of Mar2022. She noticed immediate improvement in her depression, stamina, and brain fog, although it does not prevent a crash. She should still practice pacing. She began at a dose of 1.5 mg and have titrated down to 0.1 mg and was now trying to slowly work back up to what she understands is a more therapeutic dose. She was learning that this drug must be adjusted to each individual and requires some significant time to determine the correct dosage and time of day to take it. It was her hope that there can be research to how LDN may help the "long haulers" (those of them with post COVID 19, with me/CFS, Lyme disease, multiple sclerosis, or any other auto immune illnesses). The patient asked when she could expect to return to her pre-vaccine life, how could Pfizer help, and what does the company suggest the patient to do personally to help reverse these symptoms without aggravating her condition any further.  The information on the batch/lot number for BNT162b2 has been requested and will be submitted if and when received.; Sender's Comments: Linked Report(s) : PFIZER INC-202201192058 Same patient/product, different dose/event; -PFIZER INC-PV202200072327 Same patient/product/event, different dose;