SHORTNESS OF BREATH; multiple pulmonary embolism; NAUSEA; MIGRAINE; low grade fever / 100 degree Fahrenheit; MYALGIA; This case was received via an unknown source (no reference has been entered for a health authority or license partner) on 06-Apr-2021 and was forwarded to Moderna on 06-Apr-2021.    This spontaneous case was reported by a pharmacist (subsequently medically confirmed) and describes the occurrence of PULMONARY EMBOLISM (multiple pulmonary embolism) and DYSPNOEA (SHORTNESS OF BREATH) in a 67-year-old male patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     The patient's past medical history included Drug allergy (allergy to Nonsteroidal anti-inflammatory drug and Salsalate.Fluconazole) since an unknown date, Hives since an unknown date, Rash (patient develops rash with Zipro.) since an unknown date, Hypertension since an unknown date, Hypercholesterolemia since an unknown date, Prostate cancer since an unknown date and Chronic back pain since an unknown date.    On 26-Mar-2021, the patient received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 24-Mar-2021, the patient experienced PULMONARY EMBOLISM (multiple pulmonary embolism) (seriousness criteria hospitalization and medically significant). On 27-Mar-2021, the patient experienced PYREXIA (low grade fever / 100 degree Fahrenheit ) and MYALGIA (MYALGIA). On 28-Mar-2021, the patient experienced MIGRAINE (MIGRAINE) and NAUSEA (NAUSEA). On 29-Mar-2021, the patient experienced DYSPNOEA (SHORTNESS OF BREATH) (seriousness criterion hospitalization). At the time of the report, PULMONARY EMBOLISM (multiple pulmonary embolism), DYSPNOEA (SHORTNESS OF BREATH), MIGRAINE (MIGRAINE), PYREXIA (low grade fever / 100 degree Fahrenheit ), MYALGIA (MYALGIA) and NAUSEA (NAUSEA) had not resolved.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On an unknown date, Computerised tomogram: for pulmonary embolism in lungs. On an unknown date, Ultrasound Doppler: Negative.     For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown Route), the reporter did not provide any causality assessments.   Treatment included were  Sumatriptan, Prednisone and home nebulize albuterol. Action taken with mRNA-1273 in response to the event was not applicable. There was complete workup done and he was diagnosed with pulmonary embolism with CAT scan with dye, multiple pulmonary embolism in the lungs, Ultrasound in legs which was negative. He reports that his D-dimer were very high. In conclusion his imaging and D-dimer pointed towards the pulmonary embolism diagnosis.  Company comment: Based on the current available information and temporal association between the use of the product and the start dates of the events, a causal relationship cannot be excluded.   This case was linked to US-MODERNATX, INC.-MOD-2021-068247 (E2B Linked Report).; Sender's Comments: Based on the current available information and temporal association between the use of the product and the start dates of the events, a causal relationship cannot be excluded. US-MODERNATX, INC.-MOD-2021-068247:Same reporter/Different patient