Fatigued; her nose, eyes, and everything started itching/her wrist was just itchy/generalized itching; hives in sporadic places; felt off; diarrhea; her nose, eyes, and everything started itching; had some nausea; This spontaneous case was reported by a consumer (subsequently medically confirmed) and describes the occurrence of PRURITUS (her nose, eyes, and everything started itching/her wrist was just itchy/generalized itching), URTICARIA (hives in sporadic places), VACCINATION COMPLICATION (felt off), DIARRHOEA (diarrhea) and EYE PRURITUS (her nose, eyes, and everything started itching) in a 70-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 014C21A and 05C21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     The patient's past medical history included Hives. Concurrent medical conditions included Bee sting, Wasp sting (Anaphylactic reaction to bee wasps) since June 2015, Drug allergy (pure drug tested to anaphylactic reactions to both class of local anesthetics.), Sulfonamide allergy (She also had Steven Johnson syndrome to sulfa drugs.), Drug allergy (also has topical issues including to TobraDex eye drops and it gets worse as she gets older.), Hypothyroidism since 1980, Hypertension since 2000, Arrhythmia since 2005, Cholesterol blood excessive and Prediabetes. Concomitant products included ATORVASTATIN for High cholesterol, HYDROCHLOROTHIAZIDE, LOSARTAN POTASSIUM (LOSARTAN/HYDROCHLOROTHIAZIDE) and METOPROLOL SUCCINATE for Hypertension, LEVOTHYROXINE for Hypothyroidism, METFORMIN for Prediabetes, D-MANNOSE, VACCINIUM MACROCARPON (D-MANNOSE CRANBERRY EXTRA) for Urinary tract disorder, UBIDECARENONE (QUNOL LIQUID COQ10) and COLECALCIFEROL, RETINOL (VITAMIN A & D [COLECALCIFEROL;RETINOL]) for an unknown indication.   On 28-Apr-2021 at 9:15 AM, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 26-May-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. On 29-Apr-2021, the patient experienced PRURITUS (her nose, eyes, and everything started itching/her wrist was just itchy/generalized itching), URTICARIA (hives in sporadic places), VACCINATION COMPLICATION (felt off), DIARRHOEA (diarrhea), EYE PRURITUS (her nose, eyes, and everything started itching) and NAUSEA (had some nausea). On an unknown date, the patient experienced FATIGUE (Fatigued). The patient was treated with FAMOTIDINE (PEPCID [FAMOTIDINE]) for Itching, at a dose of UNK UNK, bid; CETIRIZINE HYDROCHLORIDE (ZYRTEC ALLERGY) for Hives and Itching, at a dose of UNK UNK, qhs and DIPHENHYDRAMINE HYDROCHLORIDE (BENADRYL [DIPHENHYDRAMINE HYDROCHLORIDE]) for Itching all over, Itchy eyes and Hives, at a dose of 1 dosage form. On 19-May-2021, PRURITUS (her nose, eyes, and everything started itching/her wrist was just itchy/generalized itching), URTICARIA (hives in sporadic places) and EYE PRURITUS (her nose, eyes, and everything started itching) had resolved. At the time of the report, VACCINATION COMPLICATION (felt off) and FATIGUE (Fatigued) outcome was unknown and DIARRHOEA (diarrhea) and NAUSEA (had some nausea) had resolved.            The patient reported contacting her primary care doctor. She reported the diphenhydramine was helping with hives and itching, but it was causing sedation, so she changed to cetirizine at bedtime. She was still experiencing itching and hives so her doctor added famotidine twice daily. It took 3 weeks for the adverse reactions to resolve.   This case was linked to MOD-2021-261535 (Patient Link).   Most recent FOLLOW-UP information incorporated above includes: On 31-May-2021: Follow up received on 31-May-2021, patient demographics, medical history, concomitant medications were updated On 20-Jul-2021: Event added, treatment medications added, event outcomes/dates updated, concomitant medications added