her  blood sugars have been very high; My TSH, T3 and T4 were  totally high; bleeding like a 20 y/o; she is also having hair loss; excessively tired; her hormone pellets are not working after the COVID vaccine; This is a spontaneous report from a contactable Nurse from a Pfizer sponsored program.   A 55-year old nurse (patient) reported that received the second dose of bnt162b2 (COMIRNATY; Batch/Lot Number: unknown) on 01Apr2021 as single dose  for covid-19 immunisation. The patient had received the first dose of COMIRNATY on 11Mar2021 as single dose.  Medical history included hypothyroidism, Type 1 diabetes, and postmenopausal complications. The patient was taking hormone pellets, it is estrogen and testosterone pellets before she had the vaccines. Approximately 2 months after receiving bnt162b2 in Jul2021, her blood sugars have been very high. She is requiring 6-10 unit higher doses, which has never happened since she was dx at age 18. She also takes hormones, estrogen and testosterone ( pellets inserted every 4months) and she also takes progesterone pills, and she is "bleeding like a 20 y/o." Her thyroid medication no longer works and neither does her hormone pellets. She states she had "blood drawn in September and all were extremely high, she was not absorbing any of her medications. Her TSH, T3 and T4 were totally high." This all started after the vaccine and it just keeps getting worse.  Caller stated her Synthroid was increased to 100mcg , she was also having hair loss and the  hormones were not working anymore. " The patient stated that everything was fine before she had the vaccines. Her thyroid level was normal, everything was fine and her sugars were where they needed to be. She didn't have any problems with fevers and her arm was tender but it was nothing impressive. As the months went on her sugars were continuing to go up and she was increasing her medications. She didn't touch her thyroid medication because she needed to see the doctor for that to see what was going on. With her hormone pellets she gets those every 4 months and she wasn't due until Sep2021 for those. Also her hair is falling out in handfuls to where she is going to have to get a wig. She has never had issues with her hair before, she has thick hair, but now when she washes it she gets a handful of hair and when she blow dries it she has another. Her hairdresser noticed it as well. When she was able to get in to see her endocrinologist, withheld, it wasn't time for her appointment, she didn't have to have one until Nov2021. The caller doesn't go to the doctor unless she has to or if she has a problem. She told the doctor that she doesn't feel good and she has been excessively tired. The doctor said that something must be going on and maybe her medication is not getting absorbed and maybe there is an issue with the caller's gallbladder. The MD thought it was her gall bladder but all tests were normal. The doctor had increased the caller's Synthroid from 88 mcg to 100 mcg and she has been on that for over a month and one week now with no improvement. Her hair loss continues even though she has also gotten a shampoo for that with a DHT blocker in it. She has also taken the other grass root or whatever is recommended to take that prevents hair loss. She had none of this before she received the vaccines.   The lot number for the vaccine, [BNT162B2], was not provided and will be requested during follow up.; Sender's Comments: Based on the information provided, known drug safety profile and plausible temporal association, the causality between BNT162B2 and Blood glucose increased, Blood thyroid stimulating hormone increased, Postmenopausal haemorrhage, Alopecia, Fatigue, Therapeutic product effect decreased cannot be completely excluded.  The impact of this report on the benefit/risk profile of the Pfizer product is evaluated as part of Pfizer procedures for safety evaluation, including the review and analysis of aggregate data for adverse events. Any safety concern identified as part of this review, as well as any appropriate action in response, will be promptly notified to regulatory authorities, Ethics Committees, and Investigators, as appropriate.