LOW LEVEL INFLAMMATION IN PERICARDIA; LOW LEVEL INFLAMMATION IN MENINGES; HIGH BLOOD PRESSURE; ACUTE INFLAMMATORY RESPONSE; MUSCLE CRAMPS (LEGS); COULD NOT SLEEP; MILD BRONCHITIS; HALF SIDE OF THE FACE COMPLETELY NUMB; END OF THUMB GOING NUMB; FLU-LIKE SYMPTOMS; This spontaneous report received from a patient concerned a 57 year old White and Caucasian male. The patient's height, and weight were not reported. The patient's concurrent conditions included cholesterol, and the patient always had healthy lifestyle, never had heart problems or blood pressure before, was not taking any medication. The patient experienced intolerance to medication when treated with Nurofen (ibuprofen) for drug used for unknown indication.  The patient received covid-19 vaccine ad26.cov2.s (suspension for injection, route of admin not reported, batch number: Unknown, Expiry: Unknown) dose was not reported, 1 total, administered on 06-APR-2021 on left arm for prophylactic vaccination. The batch number was not reported and has been requested. Concomitant medications included fish oil for cholesterol.  On 07-APR-2021, around at 01:00 AM, the patient started having headaches and flu-like symptoms that he could manage without medication. On 14-APR-2021, in morning, he had severe muscle cramps (calves and feet), end of thumb going numb and left side of the face completely numb (bottom half of the cheek and underneath the throat). Also had severe headaches (scale 8/10), which was very unusual for the patient. The patient called his PCP who referred him to a local clinic, they drew blood and did a chest X-ray based on the symptoms. Chest X-ray revealed mild bronchitis. Doctor suggested him to go home and stay hydrated. On 14-Apr-2021 (during the night) , patient woke up with muscle cramps in legs and feet, could not sleep because of the severity of the cramps (scale 7 to 8/10) and severe headaches (scale 8/10), could not stay laying down. On 15-Apr-2021, patient visited physician's office. Physician prescribed him steroids (prednisolone) and told him he had an acute inflammatory response to the vaccine and now has low level inflammation in pericardia and meninges (verbatim "inflammation in the bag around the brain and bag around the heart"). Patient's blood pressure (BP) was at 148/130 (his BP baseline was around 120/75) and heartrate was around 96 bpm (baseline 52-55 bpm). Doctor prescribed propranolol. Heart rate went down with propranolol, but Blood pressure was still high, so Doctor switched to losartan 25 mg. He was diagnosed with tachycardia (heart pounding out of chest). On 21-APR-2021, Doctor has scheduled a MRI to rule out blood clots which was normal and also Fibrin D dimer, result was unknown. On 22-APR-2021, patient went to the emergency room, because blood pressure (BP) was 195/138. After receiving treatment, blood pressure was 130/85 and patient went home. Couple of days later, BP was high again, doctor added amlodipine 5 mg to losartan 25 mg and referred the patient to a cardiologist who then increased the dosage to amlodipine 10 mg. Patient now takes losartan 25 mg and amlodipine 10 mg. On 27-May-2021, the patient visited cardiologist and Scheduled Computed tomography scan and electrocardiogram on Monday. Primary care physician had prescribed magnesium supplement for the cramps. The action taken with covid-19 vaccine ad26.cov2.s was not applicable. The patient recovered from flu-like symptoms, had not recovered from muscle cramps (legs), and the outcome of end of thumb going numb, half side of the face completely numb, mild bronchitis, acute inflammatory response, low level inflammation in pericardia, high blood pressure, could not sleep and low level inflammation in meninges was not reported. This report was serious (Other Medically Important Condition).; Sender's Comments: V0: 20210608039 -covid-19 vaccine ad26.cov2.s- low level inflammation in pericardia, low level inflammation in meninges, high blood pressure. This event(s) is considered unassessable. The event(s) has a compatible/suggestive temporal relationship, is unlabelled, and has unknown scientific plausibility. There is no information on any other factors potentially associated with the event(s).