3 very large red circles, super hot, itchy, swollen, orange sized circles, that hurts and stinks in her legs after 2nd dose; 3 very large red circles, super hot, itchy, swollen, orange sized circles, that hurts and stinks in her legs after 2nd dose; 3 very large red circles, super hot, itchy, swollen, orange sized circles, that hurts and stinks in her legs after 2nd dose; 3 very large red circles, super hot, itchy, swollen, orange sized circles, that hurts and stinks in her legs after 2nd dose; 3 very large red circles, super hot, itchy, swollen, orange sized circles, that hurts and stinks in her legs after 2nd dose; 3 very large red circles, super hot, itchy, swollen, orange sized circles, that hurts and stinks in her legs after 2nd dose; Headache after 2nd dose; Pain in the injection site after 2nd dose; Very tired after 2nd dose; Fever after 2nd dose( not measured); Pain all over her body after 2nd dose; Freezing after 2nd dose; Earache after 2nd dose; This spontaneous case was reported by a patient and describes the occurrence of PAIN (Pain all over her body after 2nd dose), MUSCULOSKELETAL STIFFNESS (Freezing after 2nd dose), EAR PAIN (Earache after 2nd dose), ERYTHEMA (3 very large red circles, super hot, itchy, swollen, orange sized circles, that hurts and stinks in her legs after 2nd dose) and PERIPHERAL SWELLING (3 very large red circles, super hot, itchy, swollen, orange sized circles, that hurts and stinks in her legs after 2nd dose) in a 48-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 004C21A and 006B21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     Concomitant products included LISDEXAMFETAMINE MESILATE (VYVANSE) for ADHD.   On 09-Apr-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 07-May-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 08-May-2021, the patient experienced PAIN (Pain all over her body after 2nd dose), MUSCULOSKELETAL STIFFNESS (Freezing after 2nd dose), EAR PAIN (Earache after 2nd dose), HEADACHE (Headache after 2nd dose), VACCINATION SITE PAIN (Pain in the injection site after 2nd dose), FATIGUE (Very tired after 2nd dose) and PYREXIA (Fever after 2nd dose( not measured)). On 11-May-2021, the patient experienced ERYTHEMA (3 very large red circles, super hot, itchy, swollen, orange sized circles, that hurts and stinks in her legs after 2nd dose), PERIPHERAL SWELLING (3 very large red circles, super hot, itchy, swollen, orange sized circles, that hurts and stinks in her legs after 2nd dose), SKIN ODOUR ABNORMAL (3 very large red circles, super hot, itchy, swollen, orange sized circles, that hurts and stinks in her legs after 2nd dose), PRURITUS (3 very large red circles, super hot, itchy, swollen, orange sized circles, that hurts and stinks in her legs after 2nd dose), FEELING HOT (3 very large red circles, super hot, itchy, swollen, orange sized circles, that hurts and stinks in her legs after 2nd dose) and PAIN IN EXTREMITY (3 very large red circles, super hot, itchy, swollen, orange sized circles, that hurts and stinks in her legs after 2nd dose). On 09-May-2021, PAIN (Pain all over her body after 2nd dose), MUSCULOSKELETAL STIFFNESS (Freezing after 2nd dose), FATIGUE (Very tired after 2nd dose) and PYREXIA (Fever after 2nd dose( not measured)) had resolved. At the time of the report, EAR PAIN (Earache after 2nd dose), ERYTHEMA (3 very large red circles, super hot, itchy, swollen, orange sized circles, that hurts and stinks in her legs after 2nd dose), PERIPHERAL SWELLING (3 very large red circles, super hot, itchy, swollen, orange sized circles, that hurts and stinks in her legs after 2nd dose), SKIN ODOUR ABNORMAL (3 very large red circles, super hot, itchy, swollen, orange sized circles, that hurts and stinks in her legs after 2nd dose), PRURITUS (3 very large red circles, super hot, itchy, swollen, orange sized circles, that hurts and stinks in her legs after 2nd dose), FEELING HOT (3 very large red circles, super hot, itchy, swollen, orange sized circles, that hurts and stinks in her legs after 2nd dose), PAIN IN EXTREMITY (3 very large red circles, super hot, itchy, swollen, orange sized circles, that hurts and stinks in her legs after 2nd dose), HEADACHE (Headache after 2nd dose) and VACCINATION SITE PAIN (Pain in the injection site after 2nd dose) had not resolved.            Patient took Advil every 6 hours and Allegra D. Action taken with mRNA-1273 (Moderna COVID-19 Vaccine) in response to the event was not applicable.