couldn't feel the legs; they were completely numb; lower body numb; aches and pains; soreness; weakness in legs; unable to move both legs; couldn't swing the body over to move; cold sweats; fever 101.6; This is a spontaneous report from a contactable healthcare professional (patient). A 68-year-old female patient received BNT162B2 (PFIZER-BIONTECH COVID-19 mRNA VACCINE, Solution for injection), via an unspecified route of administration, administered in right arm, on 25Mar2021 at 11:00 (Batch/Lot Number: ER8727) (at the age of 68 years old) as dose 1, single for COVID-19 immunisation. Medical history included fibromyalgia on 2008; osteoarthritis on 2008; anxiety on 1995 (for about 26 years); depression on 1995 (for about 26 years); knee replacement (the right one was on Oct2010 and the left one was on Dec2011); blood pressure management; on sedative therapy; COVID-19 at the beginning of Jan2021; shingles [on 2007 and 03Mar2021 (Treatment: Valacyclovir hydrochloride 1 g 3 times a day)]; titanium in both legs. Concomitant medications included valsartan, taken for blood pressure management from 2009 and ongoing (for 12 years); alprazolam, taken for anxiety from 2000 and ongoing (for 21 years); fluoxetine hydrochloride, taken for depression from 2019 and ongoing (for 2 years); trazodone, taken to help the patient sleep from Dec2020 and unknown if ongoing (about 3 months ago). The patient did not receive any other vaccines within 4 weeks prior to the COVID vaccine. On 25Mar2021 at 23:00, 12 hours after the vaccination, the patient experienced fever of 101.6. On 26Mar2021, the patient was unable to move both legs, couldn't swing the body over to move, and experienced cold sweats. On 27Mar2021, the patient couldn't feel the legs, they were completely numb, lower body numb; experienced aches and pains, soreness; and had weakness in legs. The clinical course of the events was as follows: On Thursday, 25Mar2021, the patient got the COVID vaccine, 12 hours later, her temperature was a fever of 101.6, and on 27Mar2021, she had aches and pains that were worse than when she actually had COVID. The severe aches and pains resolved on 28Mar2021, then all she had was the soreness. On 26Mar2021, for the next 3 nights, the patient had cold sweats; she had to change the sheets and everything. On 26Mar2021, the patient tried to get out of bed and both of her legs, she could not move them, she couldn't swing her body over to move to the side of the bed, everything else she expected. She lives by herself and has titanium in both legs, and it scared her. She asked why could she not move. She said the only thing left was weakness in her legs. The patient stated that she kept trying to move her legs that day, and finally she was able to swing her body to get her legs over the side of the bed, but she still couldn't feel her legs. There was no cramping, no muscle pain; they were completely numb; she was hitting both of her legs and finally she felt a little bit of feeling. The only thing that scared her, is why did her lower body go numb. The events did not result to emergency room or physician office visit. The patient underwent lab tests and procedures which included fever of 101.6 on 25Mar2021 (12 hours after the vaccination). The patient has taken one diphenhydramine (BENADRYL) as treatment for the events and felt better. The outcome of event cold sweats was recovered on 28Mar2021; the events aches and pains, soreness was not recovered; the events unable to move both her legs, couldn't swing the body over to move; couldn't feel the legs, they were completely numb, lower body numb; fever of 101.6; weakness in legs was unknown. The patient's second dose vaccination schedule was on 15Apr2021.  No follow-up attempts are possible. No further information is expected.