HAVING ISSUE WITH HER VEINS; LUMP (SIZE OF A PEA) ON HER RIGHT LEG; PAIN IN RIGHT LEG; THROMBOCYTOPENIA; CHILLY; FEVER 101.1 DEGREES F; HOT /COLD; This spontaneous report received from a patient concerned a 52 year old white female of an unknown ethnic origin. The patient's weight was 263 pounds, and height was not reported. The patient's past medical history included: bariatric surgery, broken knee, 4 damaged discs in her lower back during a fall, broken ankle sustained in a separate incident, and hernia surgery. The patient experienced weight gain when treated with cortisone for 4 damaged discs in her lower back.  The patient received Covid-19 vaccine ad26.cov2.s (suspension for injection, route of admin not reported, batch number: 043A21A, and expiry: unknown) dose was not reported, dose number in series was 1, 1 total, administered on 03-APR-2021 on right arm for prophylactic vaccination. No concomitant medications were reported.  On an unspecified date, the patient was having issue with her veins. On an unspecified date in APR-2021, after receiving the vaccine, the patient was chilly and hot and she said that her husband wanted to turn the AC (Air Conditioner) on but she was so cold she had 3 covers on. The patient said at that time she measured her temperature twice and both times it was 101.1 Fahrenheit. On 16-DEC-2021, the patient noticed a black mark on her right leg (bottom of the knee) and that the area where the mark was very painful. On 19-DEC-2021, the patient then noticed another area on her leg similar to what she had discovered on 16-DEC-2021. The patient also stated that she had a lump (size of a pea) on her right leg at the bottom of the knee that she was afraid to touch and her right leg below the knee was purple. On 20-DEC-2021, the patient went to see her PCP (primary care physician) who told her that he did not think that there was anything to be concerned about and that her leg was just bruised and then patient decided to seek a secondary opinion from an other doctor who had previously treated her and was also a personal friend. The doctor through pictures and video told her that the patient had thrombocytopenia (the caller was not 100 percent sure that this was the word the doctor used it was thombo something) and told her to see a vein specialist as this condition could be fatal. The patient has been unable to get an appointment as she needed a referral from her PCP (primary care physician) which she could not get since the physician said that there was nothing wrong with her leg.  The action taken with covid-19 vaccine ad26.cov2.s was not applicable. The patient recovered from hot /cold, chilly, and fever 101.1 degrees F, had not recovered from thrombocytopenia, lump (size of a pea) on her right leg, and pain in right leg, and the outcome of having issue with her veins was not reported. This report was serious (Other Medically Important Condition).; Sender's Comments: V0: 20211251817-COVID-19 VACCINE AD26.COV2.S-Thrombocytopenia. This event is considered unassessable. The event has a compatible/suggestive temporal relationship, is unlabeled, and has unknown scientific plausibility. There is no information on any other factors potentially associated with the event.