Rebound COVID/ After feeling fine for 5-7 days, symptoms returned and re-tested positive on rapid home test; This spontaneous case was reported by a patient and describes the occurrence of COVID-19 (Rebound COVID/ After feeling fine for 5-7 days, symptoms returned and re-tested positive on rapid home test) in a 34-year-old male patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination.     Concomitant products included ACETAMINOPHEN from 11-May-2022 to 13-May-2022 and IBUPROFEN from 11-May-2022 to 13-May-2022 for an unknown indication.    On an unknown date, the patient received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On an unknown date, the patient experienced COVID-19 (Rebound COVID/ After feeling fine for 5-7 days, symptoms returned and re-tested positive on rapid home test). The patient was treated with NIRMATRELVIR, RITONAVIR (PAXLOVID) from 11-May-2022 to 16-May-2022 for COVID-19 treatment, at an unspecified dose and frequency. At the time of the report, COVID-19 (Rebound COVID/ After feeling fine for 5-7 days, symptoms returned and re-tested positive on rapid home test) outcome was unknown.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On 21-May-2022, SARS-CoV-2 test: positive (Positive) After feeling fine for 5-7 days, symptoms returned and re-tested positive.         The patient had rebound COVID. After feeling fine for 5-7 days, symptoms returned on 21-May-2022 and re-tested positive on rapid home test.  Device date was 22-May-2022.  Company Comment: This spontaneous case concerns a 34-year-old, male patient with no reported medical history, who experienced the unexpected, non-serious adverse event of special interest COVID-19. The event occurred after receiving mRNA-1273 as third COVID-19 vaccine dose given on an unspecified date, wherein she contracted COVID-19 infection and was treated with a full course of NIRMATRELVIR/RITONAVIR (Paxlovid), along with intake of Acetaminophen/Ibuprofen. After completion of treatment, the patient reported initially feeling fine; but after a week, unspecified symptoms returned. The patient then used a rapid home kit where he tested positive again to the virus. Details on confirmatory testing done, medical consult and intervention administered after were not provided in the case. The ongoing COVID-19 pandemic remains a confounder for contracting the infection. The benefit-risk relationship of mRNA-1273 is not affected by this report.; Sender's Comments: This spontaneous case concerns a 34-year-old, male patient with no reported medical history, who experienced the unexpected, non-serious adverse event of special interest COVID-19. The event occurred after receiving mRNA-1273 as third COVID-19 vaccine dose given on an unspecified date, wherein she contracted COVID-19 infection and was treated with a full course of NIRMATRELVIR/RITONAVIR (Paxlovid), along with intake of Acetaminophen/Ibuprofen. After completion of treatment, the patient reported initially feeling fine; but after a week, unspecified symptoms returned. The patient then used a rapid home kit where he tested positive again to the virus. Details on confirmatory testing done, medical consult and intervention administered after were not provided in the case. The ongoing COVID-19 pandemic remains a confounder for contracting the infection. The benefit-risk relationship of mRNA-1273 is not affected by this report.