This case was reported by a nurse via other manufacturer and described the occurrence of chest pain in a elderly female patient who received Flu Seasonal QIV Dresden for prophylaxis. The patient had a Family History of cancer, heart disease, unspecified and diabetes. Previously administered products included DPT vaccine with an associated reaction of lymphadenopathy (received on an unknown date, swollen lymph nodes under arm that lasted a year), PREVENAR 13 with an associated reaction of chest pain (received in April 2017) and Flu vaccine with an associated reaction of influenza (received years ago and gave the flu and made sick). Concurrent medical conditions included angioedema. On 24th October 2017, the patient received the 1st dose of Influenza vaccine Quadrivalent 2017-2018 season. On an unknown date, less than a year after receiving Influenza vaccine Quadrivalent 2017-2018 season, the patient experienced chest pain and costochondritis. On an unknown date, the outcome of the chest pain and costochondritis were recovered/resolved. The reporter considered the chest pain and costochondritis to be related to Influenza vaccine Quadrivalent 2017-2018 season. Additional details were reported as follows: This case was reported by the patient who was a retired registered nurse and social worker. The patient had a reaction to thimerosal, a preservative in the past, and had called to ask PREVENAR 13 had Thiomersal in it. The patient had a reaction to the diphtheria vaccine DPT also had reaction to a flu vaccine that was swollen lymph nodes under her arm in the past. The patient clarified that the diphtheria vaccine DPT caused the lymph nodes under her left arm that lasted a year. The patient stated that the flu vaccine, she had years ago and it would give her the flu and made her sick, but further stated that she had started to get the flu vaccine again since she was over 65 years. The patient additionally clarified that she had a significant number of allergies and experienced angioedema when she had an allergy and had gotten an allergy test performed. When trying to search for paperwork around the house, the patient stated sorry it was taking a while, further stating that she fell and broke her arm. The patient stated that the swollen lymph nodes under the arm from the Diphtheria Vaccine DPT occurred around the age of 28 and last for a year. The patient that she had a mammogram performed in regard to that. The patient clarified that it was under the left armpit. The patient clarified that she had only received the Flu Vaccine between ages of 22 and 24, and when receiving the flu vaccine, she has not gotten sick or gotten the flu in the last 3 years of getting the flu vaccine. The patient stated that she had started getting the Flu vaccine again in 1963. The patient stated that her reaction to the Diphtheria Vaccine DPT might have occurred because of the frequency in which she had gotten the Diphtheria Vaccines DPT. The patient stated that with onset at age 40 she was allergic to every pain medication, foods, antibiotics, phosphates further stating that she was not allergic but intolerant and got a face rash, thimerosol, formaldehyde, and annatto. The patient was queried name of Pain medications and antibiotics she stated that she had 28 allergies, in which she gets facial edema and with Annatto experiences closing of the throat and would not like to provide them at the time of reporting. Concomitant medications and investigations queried, but none to provide. The age at vaccination not reported. The patient received PREVENAR 13, flu vaccine and diphtheria vaccine DPT in the left upper arm. On an unknown date in April 2017, the patient received PREVENAR 13 first experienced the severe chest pain in April 2017, in which she called the physician's office and they had stated to go to the hospital. The chest pain lasted for a week and also this condition costochondritis that was an inflamed rib cage. The patient also had ribs inflamed, joint pain and muscle pain. The patient stated that she was diagnosed with costochondritis after the PREVENAR 13. The patient stated that the severe chest pain lasted for 8 days and the onset was the day after receiving the PREVENAR 13, further stating that she was unsure if the product was called PREVENAR or PREVENAR 13 stating that she had not documented the 13. The patient stated that she went to the emergency room, but was not admitted, and was relieved to know it was not a heart attack. The patient stated that a month or 2 later she after receiving the PREVENAR 13, caller states that she had a Flu Vaccine in which the severe chest pain happened again.