lost peripheral vision; vascular spasms which could be impacting blood flow to the optic nerve; Loss of vision in both eyes for approximately 10 seconds; Pinpoint vision with straight lines / narrowing of vision like pinpoint straight black lines or black straws then everything went black; 3 or 4 episodes of memory loss; ice cold sensation around her head; head felt strange; low voltage electricity going through her head / felt like a knife stabbing on the left side of her head and then on the right side of the head; chickenpox can lie dormant in the termporal lobe of the brand / Shingrix may have disturbed that.; headache; Body aches; Sore, aching arm; This case was reported by a nurse via call center representative and described the occurrence of loss of vision in a 68-year-old female patient who received Herpes zoster (Shingrix) for prophylaxis.   The patient's past medical history included shingles (shingles in the early 2000s, between 2004-2006.). Previously administered products included Zostavax.   On 7th November 2020, the patient received the 2nd dose of Shingrix (intramuscular). On 7th November 2020, less than a day after receiving Shingrix, the patient experienced pain in arm, feeling cold, feeling abnormal, head discomfort and chickenpox. On 8th November 2020, the patient experienced memory loss. In November 2020, the patient experienced headache and general body pain. On 11th December 2020, the patient experienced loss of vision (serious criteria GSK medically significant) and abnormal vision. On an unknown date, the patient experienced peripheral vision defective and spasms. On 11th December 2020, the outcome of the loss of vision was recovered/resolved. On an unknown date, the outcome of the pain in arm, general body pain and abnormal vision were recovered/resolved and the outcome of the headache and memory loss were not recovered/not resolved and the outcome of the feeling cold, feeling abnormal, peripheral vision defective, spasms, head discomfort and chickenpox were unknown.   The reporter considered the loss of vision, pain in arm, headache, general body pain, memory loss and abnormal vision to be related to Shingrix. It was unknown if the reporter considered the feeling cold, feeling abnormal, peripheral vision defective, spasms, head discomfort and chickenpox to be related to Shingrix.  Additional details were provided as follows: The age at vaccination was not reported. Patient had shingles in the early 2000s, between 2004-2006. Patient received Zostavax in 2011. It was reported that patient received the second dose of Shingrix on 7th November 2020 and experienced sore, aching arm (occurred the same day and lasted approximately 3-4 days),severe headache (began day second dose received on 11/7/2020 and was ongoing), body aches (began day of second dose, on 11/7/2020), 3 or 4 episodes of memory loss(began the day after receiving the second dose, on 11/8/2020. Last occurrence on 12/20/2020) Patient also experienced pinpoint vision with straight lines (occurred a week prior to 12/18/20), and loss of vision in both eyes for approximately 10 seconds (occurred a week prior to 12/18/20). HCP suggested that symptoms were related to Shingrix. It was also stated that patient experienced vision loss she initially felt like there was a low voltage electricity going through her head.and lost peripheral vision also regarding forward vision, she experienced a narrowing of vision like pinpoint straight black lines or black straws then everything went black,all of this all lasted about 10 seconds in total. Patient also felt heard strange. Patient did some testa like CT scan of her brain with and without contrast dye and it came back negative and had a CT scan with contrast dye of her carotid and it came back negative.  She was cleared by Cardiac and she was having an MRI with contrast dye. On 7th November 2020 patient also experienced an ice cold sensation around her head which lasted for maybe a week or less, on same night felt like a knife stabbing on the left side of her head and then on the right side of the head. Physician mentioned she could be having vascular spasms which could be impacting blood flow to the optic nerve and also mentioned that chickenpox can lie dormant in the termporal lobe of the brand and that Shingrix may have disturbed that. The reporter consented to follow up.