Still has SOB with exertion; Itchy rash; Less strength in her left arm than before the vaccine; Itchy skin blisters; Arm hot below the injection site; Itchy skin blisters; Pain in her arm; Burning skin blisters; Covid arm; Arm hard below the injection site; Shoulder pain / worsening of left shoulder pain; Arm red below the injection site; Fever/fever fluctuated between these temperatures for 3 days; This spontaneous case was reported by a nurse and describes the occurrence of ASTHENIA (Less strength in her left arm than before the vaccine), PRURITUS (Itchy skin blisters), VACCINATION SITE WARMTH (Arm hot below the injection site), BLISTER (Itchy skin blisters) and PAIN IN EXTREMITY (Pain in her arm) in a 72-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch no. 053C21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     The patient's past medical history included COVID-19. Concomitant products included AMLODIPINE BESILATE (NORVASC) for Blood pressure high.    On 28-Jun-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 28-Jun-2021, the patient experienced PYREXIA (Fever/fever fluctuated between these temperatures for 3 days). On 29-Jun-2021, the patient experienced PRURITUS (Itchy skin blisters), VACCINATION SITE WARMTH (Arm hot below the injection site), BLISTER (Itchy skin blisters), PAIN IN EXTREMITY (Pain in her arm), BURNING SENSATION (Burning skin blisters), VACCINATION SITE REACTION (Covid arm), VACCINATION SITE INDURATION (Arm hard below the injection site), ARTHRALGIA (Shoulder pain / worsening of left shoulder pain) and VACCINATION SITE ERYTHEMA (Arm red below the injection site). On 06-Jul-2021, the patient experienced ASTHENIA (Less strength in her left arm than before the vaccine). On 09-Jul-2021, the patient experienced RASH PRURITIC (Itchy rash). On an unknown date, the patient experienced DYSPNOEA EXERTIONAL (Still has SOB with exertion). The patient was treated with PARACETAMOL (TYLENOL) for Fever, at a dose of 1 dosage form; ACYCLOVIR [ACICLOVIR] on 29-Jun-2021 for Blister, at a dose of 800 milligram four times per day; TRIAMCINOLONE ACETONIDE (KENALOG ORABASE) on 07-Jul-2021 for Blister, at a dose of 1 dosage form and DIPHENHYDRAMINE HYDROCHLORIDE (BENADRYL A) on 03-Jul-2021 for Itching, at a dose of 1 dosage form. On 01-Jul-2021, PYREXIA (Fever/fever fluctuated between these temperatures for 3 days) had resolved. On 09-Jul-2021, PRURITUS (Itchy skin blisters) and BURNING SENSATION (Burning skin blisters) had resolved, BLISTER (Itchy skin blisters) outcome was unknown. At the time of the report, ASTHENIA (Less strength in her left arm than before the vaccine), VACCINATION SITE WARMTH (Arm hot below the injection site), PAIN IN EXTREMITY (Pain in her arm), RASH PRURITIC (Itchy rash), DYSPNOEA EXERTIONAL (Still has SOB with exertion), VACCINATION SITE REACTION (Covid arm), VACCINATION SITE INDURATION (Arm hard below the injection site), ARTHRALGIA (Shoulder pain / worsening of left shoulder pain) and VACCINATION SITE ERYTHEMA (Arm red below the injection site) outcome was unknown.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): In November 2020, SARS-CoV-2 test: positive (Positive) Positive. On 29-Jun-2021, Body temperature: 102.4 (High) 102.4 degree F .  After taking Tylenol fever reduced to 99.4degree F. On 01-Jul-2021, Blood pressure measurement: 161/94 (High) 161/94mmHg. On 01-Jul-2021, X-ray: negative (Negative) Negative  Shoulder x-ray was normal.. On 06-Jul-2021, Grip strength: abnormal (abnormal) abnormal  less strength in her left arm than before the vaccine. On 07-Jul-2021, Culture: negative (Negative) Negative for Shingles or herpes.     The action taken with mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) was unknown.   For mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular), the reporter did not provide any causality assessments.   Patient reported that her arm was red and hot for 6 x 3 inches. The patient also reported that she was not planning for second dose.