This spontaneous case was reported by a patient and describes the occurrence of MUSCULOSKELETAL STIFFNESS (stiffens up overnight), MUSCULOSKELETAL PAIN (The pain then moved to his hands, then to other parts of his body including his thighs, buttocks, and back), MUSCLE TIGHTNESS (These pains tighten his whole body), BACK PAIN (The pain then moved to his hands, then to other parts of his body including his thighs, buttocks, and back) and MUSCLE ATROPHY (muscle loss/degradation) in a 74-year-old male patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 032B21A and 026A21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below. The patient's past medical history included Hip replacement (Patient had pain in his right hip that felt similar before it was replaced). On 10-Mar-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 07-Apr-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. On an unknown date, the patient experienced MUSCULOSKELETAL STIFFNESS (stiffens up overnight), MUSCULOSKELETAL PAIN (The pain then moved to his hands, then to other parts of his body including his thighs, buttocks, and back), MUSCLE TIGHTNESS (These pains tighten his whole body), BACK PAIN (The pain then moved to his hands, then to other parts of his body including his thighs, buttocks, and back), MUSCLE ATROPHY (muscle loss/degradation), CARPAL TUNNEL SYNDROME (hand specialist who stated he has carpal tunnel), NECK PAIN (pain in my neck), PAIN (bout of pain where he had pain go across his body about where his intestines are), PAIN IN EXTREMITY (moved to my hands/ The pain then moved to his hands, then to other parts of his body including his thighs, buttocks, and back) and ARTHRALGIA (pain in my left hip/had pain in his right hip that felt similar before it was replaced). At the time of the report, MUSCULOSKELETAL STIFFNESS (stiffens up overnight), MUSCULOSKELETAL PAIN (The pain then moved to his hands, then to other parts of his body including his thighs, buttocks, and back), MUSCLE TIGHTNESS (These pains tighten his whole body), BACK PAIN (The pain then moved to his hands, then to other parts of his body including his thighs, buttocks, and back) and PAIN IN EXTREMITY (moved to my hands/ The pain then moved to his hands, then to other parts of his body including his thighs, buttocks, and back) outcome was unknown, MUSCLE ATROPHY (muscle loss/degradation) and CARPAL TUNNEL SYNDROME (hand specialist who stated he has carpal tunnel) had not resolved and NECK PAIN (pain in my neck), PAIN (bout of pain where he had pain go across his body about where his intestines are) and ARTHRALGIA (pain in my left hip/had pain in his right hip that felt similar before it was replaced) had resolved. DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On an unknown date, Magnetic resonance imaging: some degradation and muscle loss of his biceps and triceps. No concomitant medications were reported. The patient stated that from the time he received the shot he started to have a pain in neck that lasted for 4 months before going away. The patient then all of a sudden had a pain in left hip and it lasted for 2 months before it resolved. The pain then moved to the patient hands, then to other parts of the body including thighs, buttocks, and back. These pains tightened the whole body. Upon sleeping this pain would return the next morning and the patient stiffened up overnight. He has spoken to their HCP a physician assistant who recommended the patient to get an MRI of the whole body which showed some degradation and muscle loss of patient biceps and triceps. The patient then also went to see a hand specialist who stated that the patient had carpal tunnel and would like to operate. It was also reported that the patient was planning on seeing an upper extremity specialist for the biceps and triceps on 24-Aug-2022. The patient further stated that he has also had one seemingly unrelated bout of pain where he had pain go across the body about where the intestines are. This pain lasted for 3 days but went away after he used the restroom. Treatment information reported by the patient stated that the patient had been running in the pool for 30 minutes, taking steam baths, and showering at the gym each day which improved the pain for the rest of the day. Reportedly, the patient had also been taking stuff that get at the drug store to help with the pain. This case was linked to US-MODERNATX, INC.-MOD-2022-629621. Sender's Comments:  US-MODERNATX, INC.-MOD-2022-629621: Crosslinked to MOD22-021129 (Same Reporter).