Triggered autoimmune disorder; Muscle weakness in arms/legs; Tachycardia; Muscle rigidity causing difficulty walking; Muscle rigidity causing difficulty walking; Debilitating headaches; Vertigo w/nausea; Muscle stiffness in jaw leading to significant weight loss; chronic inflammation; Muscle stiffness in jaw leading to significant weight loss; chronic inflammation; Extreme debilitating general fatigue; Muscle stiffness in jaw leading to significant weight loss; chronic inflammation; Vertigo w/nausea; This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP). The reporter is the patient.  A 48 year-old female patient (not pregnant) received bnt162b2 (BNT162B2), administration date 28Apr2021 (Lot number: BW 0174) as dose 2, single for covid-19 immunisation. The patient's relevant medical history and concomitant medications were not reported. Vaccination history included: Bnt162b2 (Dose Number 1, Batch/Lot No: 2W 0150), administration date: 07Apr2021, for COVID-19 immunization. The following information was reported: AUTOIMMUNE DISORDER (disability), outcome "not recovered", described as "Triggered autoimmune disorder"; FATIGUE (disability), outcome "not recovered", described as "Extreme debilitating general fatigue"; MUSCULAR WEAKNESS (disability), outcome "not recovered", described as "Muscle weakness in arms/legs"; TACHYCARDIA (disability), outcome "not recovered", described as "Tachycardia"; MUSCLE RIGIDITY (disability), GAIT DISTURBANCE (disability), outcome "not recovered" and all described as "Muscle rigidity causing difficulty walking"; CLUSTER HEADACHE (disability), outcome "not recovered", described as "Debilitating headaches"; VERTIGO (disability), NAUSEA (disability), outcome "not recovered" and all described as "Vertigo w/nausea"; MUSCULOSKELETAL STIFFNESS (disability), WEIGHT DECREASED (disability), INFLAMMATION (disability), outcome "not recovered" and all described as "Muscle stiffness in jaw leading to significant weight loss; chronic inflammation". The events "triggered autoimmune disorder", "extreme debilitating general fatigue", "muscle weakness in arms/legs", "tachycardia", "muscle rigidity causing difficulty walking", "muscle rigidity causing difficulty walking", "debilitating headaches", "vertigo w/nausea", "vertigo w/nausea", "muscle stiffness in jaw leading to significant weight loss; chronic inflammation", "muscle stiffness in jaw leading to significant weight loss; chronic inflammation" and "muscle stiffness in jaw leading to significant weight loss; chronic inflammation" were evaluated at the physician office visit and emergency room visit. The patient underwent the following laboratory tests and procedures: weight: (2021) loss. Therapeutic measures were taken as a result of autoimmune disorder, fatigue, muscular weakness, tachycardia, muscle rigidity, gait disturbance, cluster headache, vertigo, nausea, musculoskeletal stiffness, weight decreased, inflammation. Clinical course: Triggered autoimmune disorder; extreme debilitating general fatigue and muscle weakness in arms/legs; tachycardia; muscle rigidity causing difficulty walking; debilitating headaches; vertigo w/nausea; muscle stiffness in jaw leading to significant weight loss; chronic inflammation. These are the most prominent and persistent symptoms and events. Patient had no COVID prior vaccination. Patient was not tested for COVID post vaccination. Patient had no known allergies.  No follow-up attempts are possible. No further information is expected.