Screaming and yelling and acting like a crazy person; He is yelling and screaming at everything and it doesn't matter what it is.; He has gone like mentally insane. I mean, he is literally it's like he has lost his mind/ extreme mental duress; acting like a crazy person/ over reacting; Constant anger; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP).  A 51-year-old male patient received BNT162b2 (BNT162B2), on 29Apr2022 at 12:15 as dose 3, (booster), single (Lot number: FM9992) at the age of 51 years, in left arm for covid-19 immunisation. The patient had no relevant medical history. Concomitant medication(s) included: ZOLOFT. Vaccination history included: BNT162b2 (Dose 2, prev dose lot number: EP7533, prev dose administration time: 12:15, prev dose vaccine location: Right arm), administration date: 07May2021, when the patient was 50-year-old, for Covid-19 immunization; BNT162b2 (Dose 1, prev dose lot number: ER8731, prev dose administration time: 12:00 PM, prev dose vaccine location: Right arm), administration date: 13Apr2021, when the patient was 50-year-old, for Covid-19 immunization. The following information was reported: ANGER (non-serious) with onset 03May2022 at 12:00, outcome "not recovered", described as "Constant anger"; MENTAL DISORDER (non-serious) with onset 03May2022 at 12:00, outcome "not recovered", described as "He has gone like mentally insane. I mean, he is literally it's like he has lost his mind/ extreme mental duress"; PSYCHOTIC DISORDER (non-serious) with onset 03May2022 at 12:00, outcome "not recovered", described as "acting like a crazy person/ over reacting"; SCREAMING (non-serious), outcome "unknown", described as "Screaming and yelling and acting like a crazy person; He is yelling and screaming at everything and it doesn't matter what it is.". Relevant laboratory tests and procedures are available in the appropriate section. Therapeutic measures were not taken as a result of mental disorder, psychotic disorder, anger, screaming.  Additional information: Reporter stated calling to report stuff with husband. Reporter stated, He has completely lost his mind since he got his booster (Pfizer COVID-19 Vaccine) 2 weeks ago, screaming and yelling and acting like a crazy person. Other medical conditions: Reporter stated, No but he was developing all kinds of other problems as well from the vaccine. (Further not clarified and confirmed hence, tab left unchecked). Lab tests: Reporter stated, No. Treatment received for the event: Reporter stated, No. Reporter stated he has gone like mentally insane. I mean, he is literally it's like he has lost his mind. I mean, he is yelling and screaming at everything and it doesn't matter what it is. Is this normal? He had two other vaccines (Not clarified further) and this didn't happened. This is the booster. Relevant past drug history: Name of drug as reported: No, Reaction: Allergy. Developed extreme mental duress. Constant anger and yelling, overreacting and screaming over tiny little things. New behaviour that didn't exist prior to vaccine. Facility where the most recent COVID-19 vaccine was administered: Pharmacy or Drug Store. Did the patient receive any other vaccines within 4 weeks prior to the COVID vaccine: No. Prior to vaccination, was the patient diagnosed with COVID-19: No. Since the vaccination, has the patient been tested for COVID- 19: Yes. Known allergies: No. Other medical history: None