Lymphedema in her legs/ got lymphedema about 5-6 days after the second Pfizer vaccine; Legs were hurting like the devil; Legs were about six times the size they should be/ she has intense swelling; Peeing too much; Doesn't feel right; she is just so weak; This is a spontaneous report received from a contactable consumer (patient). An 82-year-old female patient received second dose of BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE, Solution for injection, Lot Number: EL9261; Expiration Date: 31May202, NDC: 59267-1000-2), via an unspecified route of administration, administered on left arm on 06Feb2021 at 12:00 as 2nd dose, single for COVID-19 immunisation. Medical history included ongoing emphysema, ongoing breast cancer from 2007 (she did not take chemo, just radiation) and ongoing follicular lymphoma from 2014 (did not take chemo, just radiation. Cancer was in the bone marrow, said she didn't think that has anything to do with it, has had two operations) and bone marrow cancer. The patient previously took budesonide/ formoterol fumarate (SYMBICORT) she was using SYMBICORT, but her doctor switched it a few months ago, back to ANORO), prochlorperazine maleate (COMPAZINE) she takes a couple of times per month, takes 10mg when she feels nauseated and pseudoephedrine hydrochloride (SUDAFED) she takes when she needs it. Concomitant medications included furosemide (LASIX) at 40 mg, twice a day (one 40mg pill in the morning and one 40mg pill at night) from 1985 to an unspecified date and then increased to 80 mg, twice a day (two pills (80mg total) in the morning and two (80 mg total) at night) from on an unspecified date and ongoing for blood pressure; ongoing simvastatin (ZOCOR) taken for high triglycerides; umeclidinium bromide/ vilanterol trifenatate (ANORO). Patient thought she has been on Lasix since 1985 but can't remember back that far. She was taking Zocor for a long time and stated Anoro Inhaler was a fairly new medication. For Anoro inhaler, patient stated she pulls back the thing and didn't know, maybe it pinches a pill and inhales the white powder. Relevant family medical history included none and both parents were deceased. Patient stated that her oncologist does blood tests once every four months, a test for markers and stuff like that, CBC, metabolic panel and bloodwork every 4 months. The patient previously took first dose of BNT162B2 (Lot number: EL3246, Expiration date: 30Apr2021, NDC: 59267-1000-2) via unspecified route of administration in left arm on 14Jan2021 12:00 pm for COVID-19 immunisation. It was reported that, the patient has very sexy legs, but she doesn't anymore, says she got lymphedema about 5-6 days after the second Pfizer vaccine in Feb2021. She was now going to physical therapy, to bear her out and try to understand what she's saying. Caller states 30% of the people there that have had cancer and had radiation, get the same side effect she has had, some people have it in the arms, she got hers in her leg, says she has intense swelling, called lymphedema, says her legs look like they belong on an elephant. Caller said at the physical therapy place, 30% of people who have come in for help had radiation treatment for some kind of cancer, all have different kinds of cancer, but the swelling, the lymphedema, was the side effect they've all experienced. Caller states that no one has called Pfizer and let Pfizer know, states she won't take the booster, won't have anything to do with this, says it's too scary. Caller states she was an active person, never had a problem with legs swelling or anything like that and now, her look like legs that belong on an elephant. Caller states the correlation seems to be with radiation treatment, because she has bone marrow cancer, and other ladies have breast cancer, states the only thing we all have in common was different treatments but in her own case she had no chemo, but she did have radiation. It seems like with radiation this swelling was an after effect. Caller says it's 2 or 3 things, not just that they had cancer or radiation treatment, says those of us who had radiation also got this swelling. Caller states she never had any trouble with legs or anything, says she was an active person. States some people experienced this four days after the vaccine, says hers started six days after the vaccine, says she woke up one morning, and her legs were huge. States usually legs were smaller in the morning. Caller wonders what were the ingredients that causes swelling. Caller states she doesn't know how to explain it, says like overnight turned a switch on and now her legs were going to be big and fat and ugly. Caller states the reason she's calling was because at physical therapy last Thursday, other people who had the shot had the same side effect, says the only thing the lady said, she wasn't sure if she was a nurse or not, was the relationship was not with the kind of cancer, but the radiation treatment and the shot has been causing this and wasn't surprised. Caller says she was told that about 30% that they're handling now had the Pfizer vaccine. Caller thinks that's all they gave in the state NC, no other vaccine here, says it just seems to be with this. Caller states the lymphedema, hers was in her legs, others have it in their arms, she doesn't know why it's happening. Caller states about six days after the second shot, she can't remember exactly what day, about six to seven days, she woke up one morning, and her legs were hurting like the devil in Feb2021, stated her legs were about six times the size they should be in Feb2021. Caller states usually in the morning, the swelling goes down, but this woke her up out of the blue like zap, says no warning, no nothing, just one day she woke up and that where it was. Caller states her doctor increased Lasix, she used to take one 40mg pill in the morning and one 40mg pill at night, increased it to two pills (80mg total) in the morning and two (80 mg total) at night. Caller states she is now only taking one-and-a-half-pills this morning, because she doesn't feel right and she was peeing too much in Feb2021 and was not feeling right. She doesn't want to get dehydrated. Caller states she has a doctor appointment 10Jun2021 and was going to tell him she was taking less because she was just so weak in Feb2021. Says she was weak because she's taking too much Lasix, states she was taking two 40mg morning and night. Caller states she was just concerned, she has big legs, fat legs, she calls them fat. The patient not visited emergency room. The events result in the patient visited physician office. Patient reported that she has had no shots for four months however she was going to get the high dose flu shot on 01Oct2021. No relevant tests were performed at the time of this report. The outcome of the events lymphedema and Legs were about six times the size they should be was not recovered and outcome for the other events was unknown.  No further details provided. Follow-up attempts are needed. Further information requested.