changes in skin color/darkening and lightening of skin next to private parts, back, arms; thickening of skin; peeling of skin; skin has started to become leathery and heavy; This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP) from medical information team.  A 68 year-old female patient received bnt162b2 (BNT162B2), administration date 29Sep2021 (Lot number: 30155BA) as dose 3 (booster), single for covid-19 immunisation. The patient's relevant medical history and concomitant medications were not reported. Vaccination history included: Bnt162b2 (Dose:1, Lot EN6208), administration date: 19Mar2021, for Covid-19 Immunization; Bnt162b2 (Dose:2, Lot EP7533), administration date: 08Apr2021, for Covid-19 Immunization. The following information was reported: SKIN DISCOLOURATION (non-serious), outcome "unknown", described as "changes in skin color/darkening and lightening of skin next to private parts, back, arms"; SKIN HYPERTROPHY (non-serious), outcome "unknown", described as "thickening of skin"; SKIN EXFOLIATION (non-serious), outcome "unknown", described as "peeling of skin"; SKIN DISORDER (non-serious), outcome "unknown", described as "skin has started to become leathery and heavy".  Additional information: Expiry Date of Covid Vaccine: Not Provided; The reporter and his wife (the patient) received the booster dose from COVID-19 vaccine. They noticed changes in skin color, thickening of skin, peeling of skin, darkening and lightening of skin next to private parts, back, arms. He is 74 and his wife is 68 years old. Their son who received the Moderna vaccine doesn't have any symptoms. The reporter went to a doctor and a dermatologist and received no solution.Reaction/event as reported by primary source: skin is becoming thick and it's changing in color, like getting darker, it's also starting to peel, but part of it is light. When probed for the product name, reporter states that he took the 3rd shot booster in April, since then his skin has started to become leathery and heavy. He is an engineer in biomedical electronics and worked in withheld times, he is 74 years. His skin is becoming thick and it's changing in color, like getting darker, it's also starting to peel, but part of it is light. The worst thing is that it's starting to peel, it's becoming in which the skin is just coming out next to the private parts and next to the penis. He Uses a heavy loofah to get rid of it, but its just coming again and again, it's very bad. His Wife skin is doing the same thing and that is the problem. He wants to see what's going on, the doctor said it's no big deal, if it bothers then go to the dermatologist, but reporter states that he doesn't think any doctor knows what's going. This is next to his privates and it is real heavy, like a half an inch of thick skin piece, is coming out. Reporter states that he needs to talk to the research department, he is originally from # and maybe there is something different in his DNA and his Wife's. His wide is a Doctor and his son is a Doctor but they don't know anything about this. When probed for dates of his vaccine doses, reporter states that everything is in his Medical Records, all the medicine he takes, everything about him. reporter would like to provide his physician information.   Follow-up attempts are completed. No further information is expected.; Sender's Comments: Linked Report(s) : US-PFIZER INC-202200113084 same reporter/product/event, different patient.