Rash between the body and the leg / Fairly large rash where her body meets the torso/ Rash in the stomach; Very red two spots; looks like scary and red; Legs are swollen more; Legs are swollen more; lymph nodes are swelling up; 2 inch by 1 inch rash on right inner thigh, rough and scaly/ 3/4 inch round rash left inner thigh, rough and scaly; It still fells kind of rough; This is a spontaneous report from a contactable consumer (patient's husband). A 77-year-old female patient received the first dose of BNT162B2 (PFIZER-BIONTECH COVID-19 MRNA VACCINE; solution for injection; Lot Number: FA6780) intramuscularly on 29Jul2021 at 14:40 (at the age of 77-years-old) as a single dose in the left arm for COVID-19 immunization.Medical history included stage 4 ovarian cancer, ovarian cancer that ended up going into the lymphatic system, operation for the ovarian cancer, removed some lymph nodes (when they did the operation for the cancer they had removed some lymph nodes), had a nervous breakdown many years ago and she has normally a little bit of swelling in her legs (because they took out a lot of lymph nodes), all from unspecified dates and unspecified if ongoing. The patient had no history of adverse events following prior vaccinations. Family medical history relevant to the adverse events was reported as none. Concomitant medications included diazepam (tablet; strength: 5mg) taken for nervous breakdown from an unspecified date and ongoing at 5mg, 4 times a day, as needed. The patient had not had any prior vaccines within 4 weeks of the COVID-19 vaccine. The patient had not had any additional vaccines administered on the same date of the COVID-19 vaccine. On 01Aug2021 ("3  days later"), the patient experienced rash between the body and the leg / fairly large rash where her body meets the torso/ rash in the stomach, very red two spots; looks like scary and red, legs are swollen more, lymph nodes are swelling up, 2 inch by 1 inch rash on right inner thigh, rough and scaly/ 3/4 inch round rash left inner thigh, rough and scaly and It still fells kind of rough. The course of the events was reported as follows: The reporter stated that his wife received the Pfizer vaccine on the 29th (Thursday), and yesterday, 01Aug2021 (Sunday) she had a reaction and ended up with a fairly large rash where her body meets the torso (between the body and the leg). It was very noticeable, and she noticed it when she woke up in the morning. It was where the legs meet the torso, almost between the legs on each side. The rash was fairly large but there were 2 smaller areas (very red two spots). Regarding the two spots, one was about 2 inches wide high and about 1 inch wide and the other area about 3/4 of an inch in diameter where it was not only red, but it was scary. The reporter did not know how else to explain it, but it looked scary and red. They were pretty round, were really red and rough. It was not like normal skin. They were on the inside of the thighs, the 2 spots mentioned. One side was larger and the other was smaller. It was red but glazed over and looked kind of rough, maybe not rough but not smooth skin. It was also on her legs. The reporter stated that the patient had ovarian cancer which went into her lymph nodes. Her lymph nodes were swelling up because her legs were swelling up. When they did the operation for the cancer, they had removed some lymph nodes, because the cancer went from the ovarian cancer to lymphatic cancer. She had normally a little bit of swelling in her legs because they took out a lot of lymph nodes, but the legs were swollen more than they normally were. It was like the legs swelled up. Was in the lower stomach and probably the lymph system swelled up. Whatever it was, stopped the flow. They called the drug store, which the paper said to do, the first thing yesterday. They recommended she take Benadryl, which she had. She took 2 tablets. She took one at 2:00pm and the other at 6:00pm. She did not take medicine very well. After she took it, the rash, redness was down, somewhat. The major part on her legs had gone down quite a bit. The 2 spots had only gone down a little bit. The stomach had gone down fairly less. It went along her scar, where they cut her, it turned really red. (No additional information provided on the scar or cut mentioned). The rash still felt kind of rough, and when the reporter turned it over (as reported), noted that the one was now 3 inches long and 1 inch wide. The other leg, the left leg spot was 3/4-inch round. They had turned like a brownish color and were still very scaly. There was a red line outlining the area. The redness had gone down quite a bit. The large redness was barely gone. The 2 spots were still very scaly and had now turned more brownish. The adverse events did not require a visit to the emergency room or to the physician office. The reporter stated that the patient was about to call her physician. Relevant tests were reported as none. Within the last two weeks, the patient had a complete blood test done at the cancer facility. She had complete bloodwork about 5 days before the vaccine. With cancer, they did everything, and it was back the way it should be (as reported). Some of the markers were a little bit high. The reporter stated that the second dose was scheduled for 19Aug2021 at 2:40pm. He was concerned if the patient should get the second dose. He asked whether the patient should get the second shot. He was advised to contact the primary care provider for medical advice. The reporter was surprised with how the rash went down as much as it did with the Benadryl. He asked if the rash was a common reaction. He knew it was listed but he wanted to know if there were a number of people who have had this reaction. He stated he would leave it up to the physician (regarding the second dose). He also reported that the patient had to have a scan to see if the lymph nodes had reduced in swelling because they could lead to a false positive. They were kind of going back and forth because she had the cancer of the lymphatic system and 1 reaction. According to the reports on paper from both Pfizer and Moderna, it did affect the lymph nodes. Because she was a cancer patient, her doctor who she had seen about 5 days before the shot was adamant that she got the vaccine. The clinical outcomes of the events rash between the body and the leg / fairly large rash where her body meets the torso/ rash in the stomach, very red two spots; looks like scary and red, 2 inch by 1 inch rash on right inner thigh, rough and scaly/ 3/4 inch round rash left inner thigh, rough and scaly and It still fells kind of rough were recovering/resolving after treatment with Benadryl and the clinical outcomes of the events legs are swollen more and lymph nodes are swelling up were not recovered/not resolved.