having a sore mouth; Pulse oxygen level low 75 percent; pain on the right side of her face,from her eye down to her throat; PVCs; She also had a little bit of trouble breathing and mild chest pain; She also had a little bit of trouble breathing/trouble breathing when she awoke; pain on the right side of her face, from her eye down to her throat; she began to experience swelling, warmth to touch and pain on the right side of her face, from her eye down to her throat.; swollen left side of face; having a sore throat/pain on the right side of her face, from her eye down to her throat; bandaid used on her arm was meshed with a tegaderm type substance through which the shot was given; This non-serious case was reported by a consumer via call center representative and described the occurrence of premature ventricular contractions in a 72-year-old female patient who received RSVPreF3 adjuvanted (Arexvy) for prophylaxis.   Co-suspect products included PNEUMOCOCCAL VACCINE CONJ 20V (CRM197) (PREVNAR 20) for prophylaxis.   Concurrent medical conditions included non-insulin-dependent diabetes mellitus, obstructive sleep apnea syndrome and allergy to antibiotic (allergic to Gentamycin and Vancomycin). Concomitant products included INFLUENZA VACCINE, ELASOMERAN (COVID-19 VACCINE MODERNA) and umeclidinium bromide, vilanterol trifenatate (Anoro).   On 30-OCT-2023, the patient received Arexvy (left deltoid) and PREVNAR 20 (right deltoid). On 30-OCT-2023, an unknown time after receiving Arexvy and an unknown time after starting Anoro, the patient experienced wrong technique in drug usage process (Verbatim: bandaid used on her arm was meshed with a tegaderm type substance through which the shot was given). On 31-OCT-2023, the patient experienced premature ventricular contractions (Verbatim: PVCs), chest pain (Verbatim: She also had a little bit of trouble breathing and mild chest pain), difficulty breathing (Verbatim: She also had a little bit of trouble breathing/trouble breathing when she awoke), facial pain (Verbatim: pain on the right side of her face, from her eye down to her throat), feeling of warmth facial (Verbatim: she began to experience swelling, warmth to touch and pain on the right side of her face, from her eye down to her throat.), facial swelling (Verbatim: swollen left side of face), sore throat (Verbatim: having a sore throat/pain on the right side of her face, from her eye down to her throat) and eye pain (Verbatim: pain on the right side of her face,from her eye down to her throat). On 01-NOV-2023, the patient experienced sore mouth (Verbatim: having a sore mouth) and oxygen saturation decreased (Verbatim: Pulse oxygen level low 75 percent). The patient was treated with benazepril, salbutamol (Albuterol), prednisone, methylprednisolone sodium succinate (Solumedrol), famotidine (Pepcid) and epinephrine (Adrenaline). The outcome of the premature ventricular contractions, chest pain, difficulty breathing, facial pain, feeling of warmth facial, facial swelling, sore throat, sore mouth and wrong technique in drug usage process were unknown and the outcome of the oxygen saturation decreased and eye pain were not reported.   It was unknown if the reporter considered the premature ventricular contractions, chest pain, difficulty breathing, facial pain, feeling of warmth facial, facial swelling, sore throat, sore mouth, oxygen saturation decreased and eye pain to be related to Arexvy.  It was unknown if the company considered the premature ventricular contractions, chest pain, difficulty breathing, facial pain, feeling of warmth facial, facial swelling, sore throat, sore mouth, oxygen saturation decreased and eye pain to be related to Arexvy.   Additional Information: GSK Receipt Date: 01-NOV-2023 The patient received her Arexvy vaccine in her left deltoid and Prevnar 20 in the right deltoid.  About 12 hours later she began to experience swelling, warmth to touch and pain on the right side of her face, from her eye down to her throat.  She also had a little bit of trouble breathing and mild chest pain.  She visited the emergency Room where she was treated with Benadryl, Adrenaline, Pepsid and Solumedrol.  While in the ER, she experienced a few ran of PVCs which were attributed to the Adrenaline.  She was sent home with Prednisone and Adrenaline.  This morning she reported that having a sore mouth and throat and some trouble breathing with pulse oxygen level of 75 percent, which she attributed to her obstructive sleep apnea.  She noted that there were questions on her vaccine forms which asked about allergies to gentamycin and vancomycin, to which she was definitely allergic.  She also noted that the Bandaid used on her arm was meshed with a Tegaderm type substance through which the Arexvy shot was given and she question whether it had a bearing on her reaction, which led to wrong technique in drug usage process. She also noted that just 5 days prior to this event, on 25th October 2023, she received her flu vaccine (unspecified manufacturer, high-dose) in her left deltoid and her Moderna covid vaccine in her right deltoid. It was unknown if the reporter considered the premature ventricular contractions, chest pain, difficulty breathing, facial pain, feeling of warmth facial, facial swelling, sore throat, sore mouth, oxygen saturation decreased and eye pain to be related to Prevnar 20. The reporter consented to follow up.