It seemed like I might be in menopause, given lack of period.; complete stop of menses for 8 months; severe migranes; fatigue; brain fog; heart palpitations; hot flashes; blood pressure problems; sleep problems; anxiety; nausea; Covid test result=Positive; Covid test result=Positive; This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP). The reporter is the patient.  A 38 year-old female patient (not pregnant) received bnt162b2 (BNT162B2), administered in arm left, administration date 28Mar2021 (Batch/Lot number: unknown) at the age of 38 years as dose 2, single and administered in arm left, administration date 07Mar2021 (Batch/Lot number: unknown) as dose 1, single for covid-19 immunisation. The patient's relevant medical history and concomitant medications were not reported. The following information was reported: VACCINATION FAILURE (medically significant), COVID-19 (medically significant) all with onset Aug2021, outcome "unknown" and all described as "Covid test result=Positive"; MENOPAUSE (non-serious) with onset 13Mar2022, outcome "not recovered", described as "It seemed like I might be in menopause, given lack of period."; MENSTRUAL DISORDER (non-serious) with onset 13Mar2022, outcome "not recovered", described as "complete stop of menses for 8 months"; MIGRAINE (non-serious) with onset 13Mar2022, outcome "not recovered", described as "severe migranes"; FATIGUE (non-serious) with onset 13Mar2022, outcome "not recovered", described as "fatigue"; FEELING ABNORMAL (non-serious) with onset 13Mar2022, outcome "not recovered", described as "brain fog"; PALPITATIONS (non-serious) with onset 13Mar2022, outcome "not recovered", described as "heart palpitations"; HOT FLUSH (non-serious) with onset 13Mar2022, outcome "not recovered", described as "hot flashes"; BLOOD PRESSURE ABNORMAL (non-serious) with onset 13Mar2022, outcome "not recovered", described as "blood pressure problems"; SLEEP DISORDER (non-serious) with onset 13Mar2022, outcome "not recovered", described as "sleep problems"; ANXIETY (non-serious) with onset 13Mar2022, outcome "not recovered", described as "anxiety"; NAUSEA (non-serious) with onset 13Mar2022, outcome "not recovered", described as "nausea". The events "it seemed like i might be in menopause, given lack of period.", "complete stop of menses for 8 months", "severe migranes", "fatigue", "brain fog", "heart palpitations", "hot flashes", "blood pressure problems", "sleep problems", "anxiety" and "nausea" were evaluated at the physician office visit and emergency room visit. The patient underwent the following laboratory tests and procedures: sars-cov-2 test: (Jan2021) negative; (Feb2021) negative; (Mar2021) negative; (Apr2021) negative; (May2021) negative; (Jun2021) negative; (Jul2021) negative; (Aug2021) positive; (Sep2021) negative. Therapeutic measures were not taken as a result of menopause, menstrual disorder, migraine, fatigue, feeling abnormal, palpitations, hot flush, blood pressure abnormal, sleep disorder, anxiety, nausea.  Clinical course: The patient was not pregnant during the vaccination. The patient did not receive any other vaccines within 4 weeks prior to the COVID vaccine. She had a severe immune response that caused: complete stop of menses for 8 months, evere migranes, fatigue, brain fog, heart palpitations, hot flashes, blood pressure problems, sleep problems, anxiety and nausea. It seemed like she might be in menopause, given lack of period. The symptoms have persisted for over a year and still suffering from them. She was not diagnosed with COVID-19 prior to vaccination. Since the vaccination, she was tested for COVID-19. She had no known allergies.  The lot number for bnt162b2 was not provided and will be requested during follow up.