CHEST PAIN ON LEFT LUNG; BURNING SENSATION ON LEFT SIDE WHEN INHALATION; SHAKY LEGS; ALLERGIC REACTION; AIRWAY ISSUES; DYSPHAGIA; DECREASED 02 SATURATION WHEN SLEEPING; INCREASED BLOOD PRESSURE; SWELLING BETWEEN CHEEK BONE, COLLAR BONE; This spontaneous report received from a patient concerned a 51 year old female. The patient's weight was 250 pounds, and height was not reported. The patient's past medical history included: anaphylaxis. The patient experienced drug allergy when treated with prednisone. The patient received covid-19 vaccine ad26.cov2.s (suspension for injection, route of admin not reported and batch number: 202C21A expiry: UNKNOWN) dose was not reported, 1 total, administered on 08-SEP-2021 10:00 to left arm for prophylactic vaccination. No concomitant medications were reported.   On 08-SEP-2021, the patient experienced decreased 02 saturation when sleeping, increased blood pressure, swelling between cheek bone and collar bone. The patient was able to grab 4 inches around the neck due to swelling and so many had discounted that swelling. Due to swelling caller was forced to lay on their side while sleeping to avoid pressure on neck from swelling. The patient Seen Primary Physician to try to get a medical waiver for receiving the shot on 07-SEP-2021. On 09-SEP-2021, the patient experienced dysphagia, allergic reaction and airway issues. On same day patient started taking Claritin 20mg once a day, Pepcid 20mg twice a day Benadryl 25mg at noon with more de-sating during the night. Doctor instructed patient to go to urgent Care or ER (emergency room) to receive another dose of Decadron. The patient took 75mg of Benadryl (25mg in the morning, 25mg in the afternoon and 25mg in the evening). The patient visited to local urgent care and 20mg Decadron was administered and 6mg a day for 3 days prescribed. The patient was continuing to take the Claritin, Pepcid and Benadryl. On 10-SEP-2021, the patient experienced, shaky legs. On 11-SEP-2021, the patient started to feel chest pain on left lung, burning sensation when inhaling. Ambulance was called and patient brought to emergency room by 20:00. Chalked up to Steroids and stress. The patient got sent back home on 12-SEP-2021. The patient was sent home and told to follow-up with primary Physician and 12-SEP-2021, 13-SEP-2021 was staying as low impact as possible. The Swelling was started to subside as of 13-SEP-2021. Ruled out myocarditis, pericarditis, pulmonary embolism and laboratory data included: Blood pressure (NR: not provided) 170/90 mmHg, 176/97 mmHg, and Oxygen saturation (NR: not provided) 85 %, Blood pressure (NR: not provided) 165/87 mmHg, 154/92 mmHg, and Oxygen saturation (NR: not provided) 97-98 %, 78-79, CT scan (NR: not provided) not reported, Chest X-ray (NR: not provided) not reported, and Electrocardiogram (NR: not provided) not reported. On 12-SEP-2021, Laboratory data included: Blood pressure (NR: not provided) 130/81 mmHg, Glucose (NR: not provided) elevated, and White blood cells (NR: not provided) elevated. Treatment medications (dates unspecified) included: famotidine, loratadine, dexamethasone, and diphenhydramine hydrochloride.  The action taken with covid-19 vaccine ad26.cov2.s was not applicable. The patient was recovering from swelling between cheek bone and collar bone, increased blood pressure, decreased 02 saturation when sleeping, allergic reaction, dysphagia, shaky legs, chest pain on left lung, and burning sensation on left side when inhalation, and had not recovered from airway issues. This report was serious (Other Medically Important Condition).; Sender's Comments: V0: 20210923840-covid-19 vaccine ad26.cov2.s-Decreased 02 saturation when sleeping. This event(s) is considered unassessable. The event(s) has a compatible/suggestive temporal relationship, is unlabeled, and has unknown scientific plausibility. There is no information on any other factors potentially associated with the event(s).