couldn't eat; couldn't sleep; felt weak; no ambition; lost 25 lbs; COVID-19; This spontaneous case was reported by a consumer and describes the occurrence of WEIGHT DECREASED (lost 25 lbs), FEEDING DISORDER (couldn't eat), INSOMNIA (couldn't sleep), ASTHENIA (felt weak), APATHY (no ambition) and COVID-19 (COVID-19) in an 86-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 005C21A, 029L20A and 015M20A) for COVID-19 prophylaxis.     No Medical History information was reported.   On 21-Jan-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 18-Feb-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. On 09-Dec-2021, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. In 2022, the patient experienced COVID-19 (COVID-19) (seriousness criterion hospitalization). On 01-Nov-2022, the patient experienced FEEDING DISORDER (couldn't eat) (seriousness criterion hospitalization), INSOMNIA (couldn't sleep) (seriousness criterion hospitalization), ASTHENIA (felt weak) (seriousness criterion hospitalization) and APATHY (no ambition) (seriousness criterion hospitalization). In November 2022, the patient experienced WEIGHT DECREASED (lost 25 lbs) (seriousness criterion hospitalization). At the time of the report, WEIGHT DECREASED (lost 25 lbs), FEEDING DISORDER (couldn't eat), INSOMNIA (couldn't sleep), ASTHENIA (felt weak), APATHY (no ambition) and COVID-19 (COVID-19) was resolving.            No concomitant medications were reported.  Patient was taken to the hospital by her daughter twice over the next month (unspecified) where she was diagnosed with COVID-19. The patient was given an IV and antibiotics (unspecified) at one of these appointments. The patient had lost 25 lbs since these symptoms started.  Company comment: This spontaneous case concerns an 86 year old female patient with no reported medical history, who experienced the unexpected serious (hospitalization) events of Weight decreased, Feeding disorder, Insomnia, Asthenia, Apathy, about 10 months and 23 days after; and COVID-19, unknown days after receiving the third dose of mRNA-1273 vaccine in the COVID-19 vaccination series. The patient received the primary series with the same vaccine as per the recommended schedule, and received the third dose about 9 months and 21 days after the second dose. The patient was taken to the hospital as she couldn't eat, couldn't sleep, and felt weak with no ambition. She was taken to the hospital again on an unknown date and was diagnosed with COVID-19. She was given IV and antibiotics at one of these appointments. She has lost 25 lbs since these symptoms started and the events are currently resolving. No information on risk factors, detailed clinical course, investigations was available in the report. Elderly age of the patient could be a risk factor for the events. COVID 19 pandemia could be a risk factor for COVID 19. The benefit-risk relationship of mRNA-1273 is not affected by this report.; Sender's Comments: This spontaneous case concerns an 86 year old female patient with no reported medical history, who experienced the unexpected serious (hospitalization) events of Weight decreased, Feeding disorder, Insomnia, Asthenia, Apathy, about 10 months and 23 days after; and COVID-19, unknown days after receiving the third dose of mRNA-1273 vaccine in the COVID-19 vaccination series. The patient received the primary series with the same vaccine as per the recommended schedule, and received the third dose about 9 months and 21 days after the second dose. The patient was taken to the hospital as she couldn't eat, couldn't sleep, and felt weak with no ambition. She was taken to the hospital again on an unknown date and was diagnosed with COVID-19. She was given IV and antibiotics at one of these appointments. She has lost 25 lbs since these symptoms started and the events are currently resolving. No information on risk factors, detailed clinical course, investigations was available in the report. Elderly age of the patient could be a risk factor for the events. COVID 19 pandemia could be a risk factor for COVID 19. The benefit-risk relationship of mRNA-1273 is not affected by this report.