COVID-19 positive after receiving four Pfizer COVID-19 Vaccines; COVID-19 positive after receiving four Pfizer COVID-19 Vaccines; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP) from medical information team and product quality group. The reporter is the patient.  A 70-year-old female patient received BNT162b2 (BNT162B2), on 29Jan2021 as dose 1, single (Lot number: EL1284, Expiration Date: 30Apr2021), in arm, on 19Feb2021 as dose 2, single (Lot number: EL1284, Expiration Date: 30Apr2021), in arm, on 03Oct2021 as dose 3 (booster), single (Lot number: FF2589), in arm and on 06May2022 as dose 4 (booster), single (Lot number: FM9992) at the age of 70 years, in arm for covid-19 immunisation. The patient's relevant medical history included: "high blood pressure" (unspecified if ongoing), notes: Diagnosed probably 20-30 years ago;Take blood pressure medication; "Metastatic breast cancer" (unspecified if ongoing); "Breast cancer" (unspecified if ongoing); "fever" (unspecified if ongoing); "headaches" (unspecified if ongoing); "bone lesions" (unspecified if ongoing); "Immunosuppression" (unspecified if ongoing), notes: from the Ibrance; "lesion in head" (unspecified if ongoing). Concomitant medication(s) included: IBRANCE taken for breast cancer metastatic, start date: Mar2022, stop date: 04Sep2022; LETROZOLE taken for breast cancer (ongoing); TYLENOL taken for pyrexia, headache, skin lesion, start date: Jan2022 (ongoing); XGEVA taken for bone lesion. The following information was reported: VACCINATION FAILURE (medically significant), COVID-19 (medically significant) all with onset 04Sep2022, outcome "not recovered" and all described as "COVID-19 positive after receiving four Pfizer COVID-19 Vaccines". The patient underwent the following laboratory tests and procedures: Body temperature: (2022) 102, notes: a fever every night for 3 nights; Neutrophil count: (unspecified date) lower, notes: blood work from Ibrance; Red blood cell count: (unspecified date) lower, notes: blood work from Ibrance; SARS-CoV-2 test: (04Sep2022) Positive, notes: COVID-19 positive after receiving four Pfizer COVID-19 Vaccines; White blood cell count: (unspecified date) lower, notes: blood work from Ibrance. Therapeutic measures were taken as a result of vaccination failure, covid-19.  Clinical course: It was reported that nine of her family members got COVID, her husband the only one who didn't get it. She still has a little dry cough and congestion, but pretty much she's out and about. Waited until felt better to go out. She has had all Pfizer covid vaccines (2 primary series and booster). Timing of her last booster prior to developing covid 19 infection was unclear. She called her doctor and was told to take Tylenol. She wasn't that bad, had a dry cough, and a fever every night for 3 nights and fever was 102. There was no emergency room and physician office visit. She got it from her son. Her daughter-in-law got it and then passed it around. She had immunosuppression from the Ibrance. Her blood work from Ibrance lowers white and red blood cells count, also mentioned neutrophils. That's why they wanted her to go off of Ibrance to fight the COVID. She stated that she doesn't remember when she got a flu shot, but it wasn't written down. Thinks it was more than 4 weeks. She reported that she was currently taking 125 mg and has been taking Ibrance since Mar2022. She got covid-19 infection on 04Sep2022 and was told by her healthcare provider to stop the Ibrance during the infection. She had been taking product for one week out of a 3 week cycle when she stopped Ibrance. She resumed taking it again on 15Sep2022 after seeing her oncologist. She was getting conflicting instructions on how to resume her cycle. She completed one week, took off the time, then started two weeks of Ibrance last week. Originally was told to start a new cycle, and thought they were having a hard time getting 1 week. She was then told to stop Ibrance after the 2 weeks. She clarifies she got another COVID-19 Vaccine booster when she was on Ibrance. Received the second booster during her off week of Ibrance.