severe itching; severe itching/affected every inch of her body; she doesn't sleep and can't sleep; This is a spontaneous report from a contactable consumer (patient). A female patient of an unspecified age received bnt162b2 (PFIZER-BIONTECH COVID-19 mRNA VACCINE; Solution for injection, Lot Number: EL9265, Expiration date: 31May2021), via an unspecified route of administration in the left arm on 17Feb2021 at 10:20 as dose 2, single for COVID-19 immunization. The patient medical history and concomitant medications. Historical vaccine included first dose of bnt162b2 (PFIZER-BIONTECH COVID-19 mRNA VACCINE; Solution for injection, Lot Number: EL3249, Expiration date: 31May2021), via an unspecified route of administration in the left arm on 27Jan2021 at 10:20 as dose 1, single for COVID-19 immunization and routine flu shot but that was much earlier and was last year she thinks in Oct2020. Patient stated that she had severe itching that occurred after her second Pfizer COVID injection which was administered on 17Feb2021 and the itching began two days after that injection on 19Feb2021, stated the itching was ongoing and very much current and the itching affects different parts of her body at different times and affected every inch of her body on her back, feet, head, arms, fingers and other personal parts of her body that you can use your imagination for and the itching is on every inch of her body. She stated that not everything itches at the same time but the itching is consistent and never stops and seems worse at night when she sleeps; caller states she doesn't sleep and can't sleep and is miserable due to the itching, states she has used over the counter topical solutions and different solutions and gets relief from the itching for maybe 20-30 minutes and the relief does not last. She stated if she was lucky, she has to use the solutions over each other just to get some relief and does not know if the solutions work or not because the relief was for a very short period of time, the topical solutions she administered, one was hydrocortisone cream with expiry date Dec2023 on the imprinted edge, NDC 67234-010-01 and states she was not sure what the lot number was on that tube. She also used Cortisone 10 and never used that before but has used it now and states the expiry date is Jul2022, the lot is B80599 on the side of the bottle and the UPC is on the box but she disposed of the box. She also used an old bottle of Triamcinolone Acetonide lotion 0.1% that is an old bottle that she had from a couple of years ago or longer and used to use it because she had an injection or something going on like a scalp infection and was given this and only used it as needed; stated the Triamcinolone lot number is 76245, expiry date Dec2015, NDC 52565-011-59. Also used Mometasone Furoate topical solution USP 0.1% with lot L131333, UPC code on the back of 45802-118-59, and expiry date Apr2021. Reporter stated, if the itching had happened after the 1st dose of the Pfizer COVID Vaccine, then she would not have had the 2nd dose and it is strange that this happened because if the doses are the same formula then why did the itching not happen with the first dose and then the itching happened three weeks later. She further, stated when she had the reaction of itching on her back, she was using a stick that looks like it had fingers on it and the back which has severe irritation and she gets relief of some kind but that has been going on for three weeks. She asked her pharmacist or HCP of where she gets medication and he suggested, Benadryl which she had never taken before and did not know what it was for and he explained what it was for and she got the tablets, she clarified to state it is not the brand Benadryl but the generic and she assumed it was the same kind. The first two times she took the generic Benadryl, Meijer brand, she took it three days apart and all it did was put her to sleep which was ok but she doesn't stay asleep and it made her feel hungover the next day and she decided she does not want to take that routinely but the last time she took it, it did not work at all and she was miserable all night long with the itching. She thinks the Meijer brand was still in the original packaging and it says it was allergy tablets. Patient stated for the Meijer brand of generic Benadryl, she does not know the lot number on the packaging, states she does see OLE2613, expiry date Jan2022 and the lot was not identified. The events did not result in emergency room or physician room visit. Therapeutic measures were taken as a result of severe itching (pruritus). The clinical outcome for events was unknown except not recovered for severe itching/affected every inch of her body.  No follow-up attempts are possible. No further information is expected.