No appetite after first booster; Nausea after first booster; Serious problem eating after first booster; No taste after first booster; Lost 20 Lbs. after first booster; This spontaneous case was reported by a patient and describes the occurrence of EATING DISORDER (Serious problem eating after first booster), AGEUSIA (No taste after first booster), WEIGHT DECREASED (Lost 20 Lbs. after first booster), DECREASED APPETITE (No appetite after first booster) and NAUSEA (Nausea after first booster) in a 68-year-old male patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 prophylaxis.     Concurrent medical conditions included HIV infection (taking Medications for 20 years) and Blood pressure high (High Blood Pressure since 1985 controlled with Medication) since 1985. Concomitant products included PROPRANOLOL HYDROCHLORIDE (INDERAL) for Blood pressure high.   On 01-Feb-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 26-Feb-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. In 2021, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. In 2021, the patient experienced EATING DISORDER (Serious problem eating after first booster), AGEUSIA (No taste after first booster), WEIGHT DECREASED (Lost 20 Lbs. after first booster) and NAUSEA (Nausea after first booster). On an unknown date, the patient experienced DECREASED APPETITE (No appetite after first booster). At the time of the report, EATING DISORDER (Serious problem eating after first booster), AGEUSIA (No taste after first booster), WEIGHT DECREASED (Lost 20 Lbs. after first booster) and NAUSEA (Nausea after first booster) had not resolved and DECREASED APPETITE (No appetite after first booster) outcome was unknown.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On an unknown date, CD4 lymphocytes: normal prior to vaccination and after vaccination. On an unknown date, SARS-CoV-2 test: (Negative) Negative and (Negative) Negative. On an unknown date, Viral load: normal prior to vaccination and after vaccination.. On an unknown date, Weight decreased: Lost 20 lbs.         Patient was taking unspecified concomitant medications for HIV.   After 3rd shot patient had complaints of serious problem during eating, no taste, lost 20 Lbs. and nausea. After 4th shot the problems continued. No treatment medication information was provided.  Company comment: This spontaneous case concerns a 68-year-old, male patient with relevant medical history of HIV infection, who experienced the unexpected non serious AESI of ageusia. The event occurred on an unknown date after the third dose of mRNA-1273. As reported, after 3rd shot, patient started having serious problem eating, no taste, has lost 20 Lbs, and had nausea. PCR and COVID 19 testing was negative. The patient's medical history of HIV is a confounder. As reported the events were not resolved. The benefit-risk relationship of mRNA-1273 is not affected by this report.   This case was linked to MOD-2022-651068, MOD-2022-651070 (Patient Link).; Sender's Comments: This spontaneous case concerns a 68-year-old, male patient with relevant medical history of HIV infection, who experienced the unexpected non serious AESI of ageusia. The event occurred on an unknown date after the third dose of mRNA-1273. As reported, after 3rd shot, patient started having serious problem eating, no taste, has lost 20 Lbs, and had nausea. PCR and COVID 19 testing was negative. The patient's medical history of HIV is a confounder. As reported the events were not resolved. The benefit-risk relationship of mRNA-1273 is not affected by this report.