This is a spontaneous report from a contactable other health care professional (patient). This case is of first dose. A 70-year-old male patient received first dose of bnt162b2 (PFIZER-BIONTECH COVID-19 mRNA VACCINE, Formulation: Solution for injection, Batch/Lot number EN5318), via intramuscular route of administration, administered in left deltoid, on 02Feb2021 16:00 (at the age of 70-year-old) as dose 1, single for COVID-19 immunization. Medical history included ongoing Lymphocytosis (diagnosed after colonoscopy, has gas and diarrhea every day for over a year and a half), ongoing klinefelter's syndrome (diagnosed 40 years ago), ongoing sleep apnoea syndrome (diagnosed about 13 years ago), allergic to peas, beans, and that type of thing and peanut butter from an unknown date and unknown if ongoing, arthritis from an unknown date and unknown if ongoing. Concomitant medications included testosterone cipionate (DEPO-TESTOSTERONE) taken for klinefelter's syndrome, started taking 40 years ago, last shot was 3 weeks ago, delayed getting another shot so patient does not mess up the bloodwork; buspirone hydrochloride (BUSPAR) taken for anxiety, started taking 7 years ago; bupropion hydrochloride (WELLBUTRIN) taken for depression, takes generic of Wellbutrin, taken for 7 years; C-PAP Machine, taken 13 years ago. The patient received second dose of bnt162b2 (PFIZER-BIONTECH COVID-19 mRNA VACCINE, Formulation: Solution for injection, Batch/Lot number EL9266, Expiry date May2021), via an unspecified route of administration, administered in left deltoid, on 23Feb2021 11:00 (at the age of 70-year-old) as dose 2, single for COVID-19 immunization. The patient does not receive additional vaccines administered on same date of the Pfizer Suspect. The event resulted in Physician Office visit. The patient does not receive vaccination within 4 weeks and no adverse event following prior vaccination. The patient had a severe reaction when he was stung by a wasp on the lip 8 years ago and almost ended up in Emergency Room. The patient stated the first dose hit him like a Mack truck. The patient felt like he had flu without the fever and had joint pains. The patient stated the second dose hit him like an 18-wheeler that ran over him and backed up and ran over me again. The patient contacted his doctor who works at the university where they teach medical students, and he does not know. The patient asked are these symptoms common and have they been reported. The patient stated exhausted all the time, arms legs feel heavy, joints are sore. The patient asked will it go away, is it temporary, what can he do to get better, will he hurt him if he tries to rehabilitation, can this be a cardiac condition. The patient stated first dose knocked him through a loop. The patient stated he felt very tired all week but got over it after a week. The patient stated he received the second dose, and he was completely exhausted with extreme fatigue. The patient stated he felt like he had the flu. The patient stated his joints and muscles are sore and he feels like he got ran over by about three 18-wheelers. The patient stated that everyone says the symptoms go away within a couple days, but he is still experiencing symptoms. The patient wanted to know if the extreme fatigue is normal and if it is not, will it go away, what can he do for relief, how long will it last, is it permanent, what will happen if he tries to strengthen himself and push himself, will exercise help him or hurt him. The patient stated he took his grandchildren, who are 5 and 9 years old, to the zoo. The patient stated he could keep up with the 9-year-old, but he does not had energy to chase the 5-year-old. The patient stated he came home and practically collapsed. The patient stated if these symptoms last for a long time, he had to change his lifestyle. The patient reported the doctor is ordering additional bloodwork and he needs to find out would Pfizer want him to do additional bloodwork. The patient asked what bloodwork Pfizer would recommend he has done, is this exhaustion that's lasting for four weeks a typical or atypical reaction. The patient stated he looked online, and he is hearing that normally the reactions go away within three to five days. The patient stated the reaction to first went away in 3 to 5 days, the second is 4 weeks in and he is still exhausted. The patient stated he also heard if you have a reaction to the first one that the reaction to the second one is much worse, which it is, that is concerning. The patient asked what the ramifications of this, is this something that has gone away, can he do something about this to return to normal. The patient stated he is having trouble concentrating, he thinks that is related to not having enough energy. The patient stated his symptoms are messing up his capacity to work and he will have to scale back if this is permanent. The patient stated that Pfizer can also contact his wife who is a nurse. The patient stated he had the same symptoms with the first dose. He was exhaustion, fatigue, arms, and legs felt heavy, joints were sore, but it went away after a week. The patient stated he is feeling like he has the flu as exhaustion, fatigue, arms, and legs heavy and sore. The patient stated he did not have fever. The patient stated he has minor arthritis, but it feels like he has major arthritis. The patient stated he is grunting and groaning all the time. The patient stated he does not remember when he started feeling very tired after the first dose, but the next day he went home and did not do much. The patient stated the following weekend he was okay and back to normal. The patient stated he feels 400% worse with the second dose. The patient stated if he takes his grandson for a walk, he had to rest afterwards. He used to be able to take him for a mile walk with no problems. The patient stated on Friday (26Feb2021) after the second dose, he took a two-day Interactive CE course on chronic pain, and he fell asleep eight times over the two days. He could not get credit for the course and will have to take it again. He fell asleep even after drinking two mugs of very strong French heavy dark roast coffee. The coffee couldn't keep him awake and he was sitting up in his office chair and fell asleep. The patient stated with the first dose, he went back to his normal routine and was able to function, he was tired and never got back to functioning fully. The patient stated his arms and legs feel like they weigh a thousand pounds, and this has severely aggravated arthritis. The patient mentioned that because he has been so exhausted, he has given up trying to do things. The patient stated he has a new client tomorrow at 14:00 and he does not know how it will be going to be. The patient explained he tries not to think about how he feels because it is depressing. The patient stated his arthritis was in his hands and now maybe one elbow, now it is in his hands, elbows, shoulders, hips, legs, and everything. The patient asked is its possible vaccine affected arthritis, if his responses are normal, could it affect his heart, does he now have cardiac problems because of the COVID-19 vaccine, what should he have checked in cardiac. The patient asked his wife how she felt his symptoms were doing and she replied maybe slightly improving, but not much. The patient stated he had to radically cut back on his lifestyle. The patient stated his daughter, and two grandchildren live with him, and his wife and he take his grandchildren on walks to the park. He is not doing things he used to do. The patient stated he is exhausted even walking around the house. The patient stated he told the nurse at the doctor's office; he may have picked up COVID-19 on top of it because of how he was feeling, and they checked him for COVID-19 on Friday and he did not have COVID-19. The outcome of the events after the first dose was recovered.  No follow-up attempts are needed; information about lot/batch number cannot be obtained. No further information is expected.