developed a form of dysautonomia or autonomic nervous system (or vagal nerve) dysfunction; no longer able to drive on own or work on-site; lightheadedness; panic attacks; heart began racing; became very shaky, and was unable to continue driving/body shaking; unable to drive due to the anxiety/began to experience more anxiety over the next several months; muscle soreness and body aches; inflammation for 4 days/photo taken during the time face looked puffy; This spontaneous case was reported by a patient and describes the occurrence of INFLAMMATION (inflammation for 4 days/photo taken during the time face looked puffy), PANIC ATTACK (panic attacks), PALPITATIONS (heart began racing), TREMOR (became very shaky, and was unable to continue driving/body shaking) and ANXIETY (unable to drive due to the anxiety/began to experience more anxiety over the next several months) in a 33-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch no. 045B21A) for COVID-19 prophylaxis. The occurrence of additional non-serious events is detailed below.     Concurrent medical conditions included Smoke sensitivity and Allergy to molds.    On 28-Apr-2021, the patient received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. In May 2021, the patient experienced PANIC ATTACK (panic attacks), PALPITATIONS (heart began racing), TREMOR (became very shaky, and was unable to continue driving/body shaking) and ANXIETY (unable to drive due to the anxiety/began to experience more anxiety over the next several months). In 2021, the patient experienced INFLAMMATION (inflammation for 4 days/photo taken during the time face looked puffy) and MYALGIA (muscle soreness and body aches). In November 2021, the patient experienced DIZZINESS (lightheadedness). In October 2022, the patient experienced IMPAIRED WORK ABILITY (no longer able to drive on own or work on-site). In January 2023, the patient experienced AUTONOMIC NERVOUS SYSTEM IMBALANCE (developed a form of dysautonomia or autonomic nervous system (or vagal nerve) dysfunction). The patient was treated with SELENIUM in December 2022 at an unspecified dose and frequency. In 2021, INFLAMMATION (inflammation for 4 days/photo taken during the time face looked puffy) had resolved. At the time of the report, PANIC ATTACK (panic attacks), PALPITATIONS (heart began racing), TREMOR (became very shaky, and was unable to continue driving/body shaking), ANXIETY (unable to drive due to the anxiety/began to experience more anxiety over the next several months), IMPAIRED WORK ABILITY (no longer able to drive on own or work on-site), AUTONOMIC NERVOUS SYSTEM IMBALANCE (developed a form of dysautonomia or autonomic nervous system (or vagal nerve) dysfunction) and DIZZINESS (lightheadedness) had not resolved and MYALGIA (muscle soreness and body aches) outcome was unknown.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): In December 2022, Tilt table test: (Negative) negative for POTS.     For mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular), the reporter considered INFLAMMATION (inflammation for 4 days/photo taken during the time face looked puffy), PANIC ATTACK (panic attacks), PALPITATIONS (heart began racing), TREMOR (became very shaky, and was unable to continue driving/body shaking), ANXIETY (unable to drive due to the anxiety/began to experience more anxiety over the next several months), IMPAIRED WORK ABILITY (no longer able to drive on own or work on-site), AUTONOMIC NERVOUS SYSTEM IMBALANCE (developed a form of dysautonomia or autonomic nervous system (or vagal nerve) dysfunction), DIZZINESS (lightheadedness) and MYALGIA (muscle soreness and body aches) to be related.    Concomitant product information was not provided by the reporter.  On late May 2021, patient began to experience panic attacks. The first episode occurred while she was driving on the highway, patient was unable to continue driving her husband took over driving the rest of the way. This occurred 3 more times over the next several days. Patient began to experience more anxiety over the next several months; however, the episodes didn't follow the same pattern that patient had experienced with her anxiety prior to the vaccine. On Nov 2021, after several months without significant issue, she experienced another episode while driving heart racing. Salty food and drinking water helped to resolve those episodes, and each episode would last 45-60 minutes. On Jan 2022, patient reported the episodes to gp, suggested it could be POTS and referred her to a cardiologist and she saw the cardiologist on Feb 2022, and underwent several tests an EKG, echocardiogram, and stress test, also wore a halter monitor for 1 week, which indicated no arrhythmias. Episodes at that time had decreased in frequency. On Jun 2022, the episodes began to get more frequent again. Patient was experiencing episodes up to 3 times per week. On Sep 2022, she saw an allergist, as she thought her episodes might be triggered by a mold allergy or smoke allergy. After describing the episodes, which was experiencing by the patient, the allergist suggested of having a Vaso-vagal response, triggered by heat, or insufficient food/water intake, and referred her back to cardiologist. On Jan 2023, cardiologist determined that her cardiovascular system was on good health. Due to the timing of the onset of episodes, determined that this could be a possible adverse event from the COVID-19 vaccine. On Dec 2022, patient began performing some light exercises at the suggestion of her cardiologist (which had been unable to perform because the elevated heart rate and heat could sometimes trigger an episode), she also began taking an immune support supplement with selenium. Both the exercise and the supplements were helping. Patient was still unable to drive or work onsite due to the risk of having episodes. The frequency, and severity of episodes was decreasing, but they have not fully gone away.