But after the second dose she also got neurological side effects that have not cleared up.; This is a spontaneous report received from a contactable reporter(s) (Other HCP) for a Pfizer sponsored program. The reporter is the patient.  A 74 year-old female patient received bnt162b2 (BNT162B2), administration date 03Apr2021 (Lot number: EW0151) at the age of 74 years as dose 2, single for covid-19 immunisation. Relevant medical history included: "brain injury", start date: 2019 (unspecified if ongoing); "she had a stroke" (unspecified if ongoing), notes: Pristiq really helps as well as low energy level; "arrhythmia", start date: 2018 (unspecified if ongoing), notes: Generic Pristiq; "cognitive impairment", start date: 2018 (unspecified if ongoing), notes: Generic Pristiq; "shakes", start date: 2018 (unspecified if ongoing), notes: Generic Pristiq; "irritability", start date: 2018 (unspecified if ongoing), notes: Generic Pristiq; "severe withdrawals for a month", start date: 2018 (unspecified if ongoing); "Long COVID", start date: Nov2020 (unspecified if ongoing), notes: Outcome: NOT RECOVERED/NOT RESOLVED.; "low energy level from long COVID", start date: Nov2020 (unspecified if ongoing). The patient's concomitant medications were not reported. Vaccination history included: Bnt162b2 (DOSE 1), administration date: 06Mar2021, when the patient was 74 years old, for COVID-19 immunization, reaction(s): "She had side effects from the first dose that cleared up in two weeks". The following information was reported: NEUROLOGICAL SYMPTOM (non-serious) with onset Apr2021, outcome "not recovered", described as "But after the second dose she also got neurological side effects that have not cleared up.". Relevant laboratory tests and procedures are available in the appropriate section.  Additional information: Patient on the line who takes Pristiq. She has one tablet left and she has to go get it but she made a comment that she has severe side effects and cardiac problems if she misses her medication. Agent told her the medication was sitting at the doctor's office. She has corrected this on all her medical records and her driver's license. She had a brain injury; she thinks it was about two years ago. She previously was taking Pristiq and then she started it again. She clarified the first time she took Pristiq was in 2015. She got off of brand Pristiq; that is, she had ended up taking the generic for Pristiq; she tried it for a week and started to have side effects, so she discontinued the generic for Pristiq. States she could not afford to get the brand. That was when she had to go to urgent care and was treated with Valium and diazepam or lorazepam. She was experiencing arrhythmia; cognitive impairment; shakes; irritability that lasted a month. She was coming off sleep drug. About the generic for Pristiq, adds this happened about three years ago. She went to renew her prescription and was told the generic is one fifth the price, so she tried it. About three years ago, she had severe withdrawals for a month and thought she would never take Pristiq again. She has fully recovered from those side effects and withdrawals. She had COVID 19 in Nov2020 and is still suffering from long COVID. She had a stroke and the Pristiq really helps with that, as well as helping with the low energy level from long COVID. Her doctor started her back on Pristiq in Dec2020 or Jan2021; she was on the program. She called today because the doctor upped her dose from 20mg to 50mg in Jun2021 and there was like that; it got sent to the wrong pharmacy. The long COVID really got worse when she had the second shot, referring to the Pfizer COVID 19 vaccine. Adds she had side effects from the first dose that cleared up in two weeks. But after the second dose she also got neurological side effects that have not cleared up. Now she is taking the Pristiq; but they upped the dose after the second vaccine from 20mg to 50mg. Adds she only has one tablet left of Pristiq, but she can go and pick up her prescription. Adds she has friends she has begged to get the vaccine; any other country they would be clamouring to get it. Seriousness not provided.   Follow-up attempts are completed. No further information is expected.