pain in her hands; In pain 24/7 after vaccination; Scleroderma as per 1 doctor's diagnosis  after vaccination; Hands and feet look like they have fluids in them after vaccination but they are hard to the touch/thickening of hands/hands swelling/ hands are hard to touch after vaccination; Hands look like have built up of Collagen from the protein in the vaccine,  after vaccination/s has made excessive collegan in my sisters body/Feet look like have built up of Collagen from the protein in the vaccine, after vaccination; This spontaneous case was reported by a patient family member or friend and describes the occurrence of SCLERODERMA (Scleroderma as per 1 doctor's diagnosis  after vaccination) in a 68-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     The patient's past medical history included Cancer (Patient went through chemo and radiation. The cancer went away.) in 2020, Chemotherapy and Radiotherapy.   In 2021, the patient received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. In 2021, received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. In May 2022, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. In May 2022, the patient experienced SCLERODERMA (Scleroderma as per 1 doctor's diagnosis  after vaccination) (seriousness criterion medically significant), PERIPHERAL SWELLING (Hands and feet look like they have fluids in them after vaccination but they are hard to the touch/thickening of hands/hands swelling/ hands are hard to touch after vaccination), COLLAGEN DISORDER (Hands look like have built up of Collagen from the protein in the vaccine,  after vaccination/s has made excessive collegan in my sisters body/Feet look like have built up of Collagen from the protein in the vaccine, after vaccination) and PAIN (In pain 24/7 after vaccination). On an unknown date, the patient experienced PAIN IN EXTREMITY (pain in her hands). At the time of the report, SCLERODERMA (Scleroderma as per 1 doctor's diagnosis  after vaccination), PERIPHERAL SWELLING (Hands and feet look like they have fluids in them after vaccination but they are hard to the touch/thickening of hands/hands swelling/ hands are hard to touch after vaccination), COLLAGEN DISORDER (Hands look like have built up of Collagen from the protein in the vaccine,  after vaccination/s has made excessive collegan in my sisters body/Feet look like have built up of Collagen from the protein in the vaccine, after vaccination), PAIN IN EXTREMITY (pain in her hands) and PAIN (In pain 24/7 after vaccination) outcome was unknown.            No concomitant medications were reported.    Ever since vaccination, she started having pain in her hands and swollen hands. Now her feet are swollen too. Caller stated, Patient had pain 24/7 and pain medication does not work on her kind of pain.  Her hands look like they have fluids in them but they are hard to the touch. Her hands look like they have built up of Collagen from the protein in the vaccine. Caller stated that she was sure that the vaccine was causing the built up of Collagen in her sister's body, but the doctors are not saying anything. Patient had 10 blood test and doctors did not confirm concrete diagnosis, pain medication make her worst.  Company comment. This spontaneous case concerns a 68  year  old female patient, with no relevant medical history, who received three doses of mRNA  1273 vaccine (primary schedule and a booster dose) and experienced the unexpected, serious (medically significant) event of scleroderma. The report stated that since vaccination the patient experienced pain in her hands, swollen feet, and hands. Hands seemed to have fluid and were hard to touch. One doctor she consulted thought the patient might have scleroderma, but other doctors said it was not. The reporter mentioned the vaccine caused the "built up of collagen" in patient´s body. Diagnosis was not confirmed, and unspecified pain medication made the patient worse. No further clinical details were provided for medical reviewing. The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report.   This case was linked to MOD-2022-659353 (Patient Link).   Most recent FOLLOW-UP information incorporated above includes: On 14-Oct-2022: Non Significant Follow-up appended On 14-Oct-2022: Live follow-up appended - Event information updated.; Sender's Comments: This spontaneous case concerns a 68  year  old female patient, with no relevant medical history, who received three doses of mRNA  1273 vaccine (primary schedule and a booster dose) and experienced the unexpected, serious (medically significant) event of scleroderma. The report stated that since vaccination the patient experienced pain in her hands, swollen feet, and hands. Hands seemed to have fluid and were hard to touch. One doctor she consulted thought the patient might have scleroderma, but other doctors said it was not. The reporter mentioned the vaccine caused the "built up of collagen" in patient´s body. Diagnosis was not confirmed, and unspecified pain medication made the patient worse. No further clinical details were provided for medical reviewing. The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report.