breaking out in hives and rashes all over the place; breaking out in hives and rashes all over the place; itchy/itching all over, hives and itchy skin; This is a spontaneous report from a contactable consumer (patient). A 51-year-old female patient received BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE, Formulation: Solution for injection, Lot Number: EN6205) via an unspecified route of administration, administered in Arm Right on 08Mar2021 13:00 (at the age of 51 years old) as dose 1, single for COVID-19 immunisation. Medical history included seizure from an unknown date and unknown if ongoing (seizure disorder which is treated with dilantin), brain surgery from an unknown date and unknown if ongoing (had brain surgery to place a shunt, she reported she has a shunt in her head that drains fluid down. It was major brain surgery. She had a blockage in the 3rd and 4th ventricles. The first surgery was at age 12, last surgery was at age 22), hives from an unknown date and unknown if ongoing (she has had hives before, for weeks before, but it's been about 20 years ago and she hasn't had hives since then), high blood pressure from an unknown date and unknown if ongoing (she has high blood pressure, her blood pressure is good now, she takes medicine for it). The patient's concomitant medications included dilantin and medicines for high blood pressure (She does take medicine, she has had a seizure before so she takes Dilantin, she has high blood pressure, her blood pressure is good now, she takes medicine for it). Patient did not received other vaccine within four weeks of COVID vaccine. The patient experienced breaking out in hives and rashes all over the place, itchy/itching all over, hives and itchy skin on 15Mar2021. Reported as, patient who received the first dose of the Pfizer-Biontech Covid19 vaccine 08Mar2021. She was reporting that she started "breaking out in hives all over the place" the following Monday 15Mar2021. She started taking Benadryl to treat them on Tuesday and has continued since, but she was still itchy. Patient have been breaking out in hives and rashes all over the place. not too much else has changed. On Tuesday, 16Mar2021, she bought Benadryl. She thought, should she take the Benadryl, she will die if she does not take it. She does not want to take something unless she has to. She decided to take the Benadryl. She talked to her doctor on Wednesday, 17Mar2021 and the doctor did not want to give her any medication because she had received the Covid 19 vaccine. Her doctor wanted to wait 2 weeks before prescribing. She was itching all over, she has hives and itchy skin. When she was on the Benadryl, she was ok. After several hours pass, and she waits as long as she can before taking another Benadryl, then she takes another Benadryl. She has been sleeping ok but as soon as she wakes up and stands up and starts walking around she is cringing and itchy. They are not big hives, it was more like a rash. It was located below her neck on her chest and her chest was red raw from scratching it. It was on her arms, her legs, and her back. she took the Benadryl she was still itching for an hour and a half. Treatment included Benadryl 25mg takes 1 tablet when she wakes up then 1 tablet around 4:00PM, then 1 tablet before bed. The patient underwent lab tests and procedures which included blood test: unknown on 18Mar2021. Outcome of all the events were not recovered.  No follow-up attempts are possible. No further information is expected.