Right now, caller's wife has a spike in her tumor marker. This happened 6 weeks after getting the vaccine.; She had feet swelling before she has taken the first dose of the vaccine but it had worsen after getting the Pfizer COVID-19 vaccine; She had feet swelling before she has taken the first dose of the vaccine but it had worsen after getting the Pfizer COVID-19 vaccine; This is a spontaneous report from a contactable consumer. This consumer reported for a female patient (reporter's wife) via Medical Information Team. A female patient of an unspecified age received second dose of BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE, Formulation: Solution for injection, Batch/Lot number: Unknown), via an unspecified route of administration on 16Feb2021 as single for COVID-19 immunization. Medical history included metastatic stage 4 breast cancer, peripheral swelling from an unknown date and unknown if ongoing. The patient's concomitant medications were not reported. Historical vaccine included first dose of BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE, Formulation: Solution for injection, Batch/Lot number: Unknown), via an unspecified route of administration on 26Jan2021 for COVID-19 immunization. She had the first dose of the Pfizer COVID-19 vaccine on 26Jan2021 and the second dose on 16Feb2021. She had stage 4 metastatic breast cancer. She had feet swelling before she has taken the first dose of the vaccine (caller attributed this as an AE of another cancer drug his wife was taking) but it had worsen after getting the Pfizer COVID-19 vaccine. Right now, caller's wife had a spike in her tumor marker. They had laboratory tests every month. There had been no progression of cancer but the tumor marker was doubled. This happened 6 weeks after getting the vaccine. Their oncologist was also perplexed by this matter and they think it might be possibly from the vaccine. He wanted to know any information about having inflammation after getting the Pfizer COVID-19 vaccine. Pfizer was aware of rare reports of inflammation of the heart muscle (myocarditis) and inflammation of the outer lining of the heart (pericarditis), which usually occurred in male adolescents and young adults, after mRNA COVID-19 vaccination. The Pfizer-BioNTech and Moderna COVID-19 vaccines are mRNA vaccines. More than 400 million doses of the Pfizer-BioNTech COVID-19 vaccine have been administered globally. According to the Centers for Disease Control and Prevention (or CDC), reports of myocarditis and pericarditis are rare given the number of doses administered and patients have typically rapidly improved with treatment and rest. Injection site swelling and redness, swelling of lymph nodes, and allergic reactions have also been reported as adverse events with the Pfizer COVID-19 vaccine. Swollen lymph nodes (lymphadenopathy), which generally resolved within 10 days, was likely to have resulted from a robust vaccine-elicited immune response. 0.3% of the participants in the clinical trials have experienced lymphadenopathy. The patient underwent lab tests and procedures which included laboratory test: no progression doubled. The outcome of the events was unknown.  Information regarding the Lot/Batch number has been requested.