This spontaneous case was reported by a consumer and describes the occurrence of VACCINATION SITE WARMTH (injection site has a big red circle, has a lump about 1/4 inch thick, hot and hard to touch), VACCINATION SITE VESICLES (around the lump are 2 raised bumps that looks like blisters), VACCINATION SITE MASS (around the lump are 2 raised bumps that looks like blisters), INJECTION SITE INDURATION (injection site has a big red circle, has a lump about 1/4 inch thick, hot and hard to touch) and VACCINATION SITE ERYTHEMA (injection site has a big red circle, has a lump about 1/4 inch thick, hot and hard to touch) in a 54-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below. Concurrent medical conditions included Sulfonamide allergy (Sulfur). Concomitant products included RIZATRIPTAN for Migraine headache, CITALOPRAM, TRIAMTERENE, MONTELUKAST and IBUPROFEN for an unknown indication. In August 2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 31-Aug-2021, the patient experienced VACCINATION SITE VESICLES (around the lump are 2 raised bumps that looks like blisters), VACCINATION SITE MASS (around the lump are 2 raised bumps that looks like blisters), INJECTION SITE INDURATION (injection site has a big red circle, has a lump about 1/4 inch thick, hot and hard to touch), PYREXIA (high fever of 103 degrees Fahrenheit), CHILLS (chills), MYALGIA (body aches) and HEADACHE (a terrible headache). On an unknown date, the patient experienced VACCINATION SITE WARMTH (injection site has a big red circle, has a lump about 1/4 inch thick, hot and hard to touch) and VACCINATION SITE ERYTHEMA (injection site has a big red circle, has a lump about 1/4 inch thick, hot and hard to touch). At the time of the report, VACCINATION SITE WARMTH (injection site has a big red circle, has a lump about 1/4 inch thick, hot and hard to touch), VACCINATION SITE VESICLES (around the lump are 2 raised bumps that looks like blisters), VACCINATION SITE MASS (around the lump are 2 raised bumps that looks like blisters), INJECTION SITE INDURATION (injection site has a big red circle, has a lump about 1/4 inch thick, hot and hard to touch), VACCINATION SITE ERYTHEMA (injection site has a big red circle, has a lump about 1/4 inch thick, hot and hard to touch), PYREXIA (high fever of 103 degrees Fahrenheit), CHILLS (chills), MYALGIA (body aches) and HEADACHE (a terrible headache) outcome was unknown. DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On 03-Sep-2021, Body temperature: 100.4 (High) Today her temperature is 100.4 degrees Fahrenheit. On an unknown date, Body temperature: 103 (High) had a high fever of 103 degrees Fahrenheit. The action taken with mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown) was unknown. For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown), the reporter did not provide any causality assessments. Generally the patient used to take ibuprofen and rizatriptan for her concurrent conditions, Now the treatment includes one tablet of rizatriptan and four tablets of ibuprofen of 200 mg.