Lyme and ME/CFS symptoms have been aggravated after receiving two Pfizer Covid 19 vaccines and one booster shot; Lyme and ME/CFS symptoms have been aggravated after receiving two Pfizer Covid 19 vaccines and one booster shot; Lyme and ME/CFS symptoms have been aggravated after receiving two Pfizer Covid 19 vaccines and one booster shot; These symptoms also worsened after being vaccinated: TMJ arthritis, degenerative disc disease (neuropathy in my right foot) and arthritis in my thumbs and fingers, and shoulders; lost 30% hearing in my hearing ear; symptoms aggravated/worsened after being vaccinated; arm soreness; significant increase in my anxiety and depression; more frequenct crashes/PEM (post exertional malaise); These symptoms also worsened after being vaccinated: TMJ arthritis, degenerative disc disease (neuropathy in my right foot) and arthritis in my thumbs and fingers, and shoulders; These symptoms also worsened after being vaccinated: TMJ arthritis, degenerative disc disease (neuropathy in my right foot) and arthritis in my thumbs and fingers, and shoulders; tinnitus has increased in my non-hearing ear; ability to care for myself has been significantly diminished; brain fog; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP). The reporter is the patient.  A female patient received BNT162b2 (BNT162B2), on 27Jan2021 as dose 1, single (Batch/Lot number: unknown) for covid-19 immunisation. The patient's relevant medical history included: "ME/CFS", start date: 2005 (unspecified if ongoing), notes: In 2003, I contracted CMV (cytomegalovirus) which led to the diagnosis of ME/CFS in 2005.; "Lyme disease", start date: 2007 (unspecified if ongoing), notes: I was also diagnosed with Lyme disease in 2007; "Epstein-Barr virus" (unspecified if ongoing), notes: I had of Epstein-Barr as a teenager.; "sensory  neurological deafness in my right ear", start date: 2009 (unspecified if ongoing), notes: In 2009, I developed sudden sensory neurological deafness in my right ear; "ME/CFS", start date: 2005 (unspecified if ongoing), notes: In 2003, I contracted CMV (cytomegalovirus) which led to the diagnosis of ME/CFS in 2005.; "CMV", start date: 2003 (unspecified if ongoing), notes: In 2003, I contracted CMV (cytomegalovirus) which led to the diagnosis of ME/CFS in 2005. The patient's concomitant medications were not reported. The following information was reported: LYME DISEASE (medically significant), POST VIRAL FATIGUE SYNDROME (medically significant), CHRONIC FATIGUE SYNDROME (medically significant), outcome "unknown" and all described as "Lyme and ME/CFS symptoms have been aggravated after receiving two Pfizer Covid 19 vaccines and one booster shot"; NEUROPATHY PERIPHERAL (medically significant), ARTHRITIS (non-serious), INTERVERTEBRAL DISC DEGENERATION (non-serious), outcome "unknown" and all described as "These symptoms also worsened after being vaccinated: TMJ arthritis, degenerative disc disease (neuropathy in my right foot) and arthritis in my thumbs and fingers, and shoulders"; HYPOACUSIS (medically significant), outcome "unknown", described as "lost 30% hearing in my hearing ear"; CONDITION AGGRAVATED (medically significant), outcome "unknown", described as "symptoms aggravated/worsened after being vaccinated"; PAIN IN EXTREMITY (non-serious), outcome "unknown", described as "arm soreness"; DEPRESSION (non-serious), outcome "recovering", described as "significant increase in my anxiety and depression"; MALAISE (non-serious), outcome "unknown", described as "more frequenct crashes/PEM (post exertional malaise)"; TINNITUS (non-serious), outcome "unknown", described as "tinnitus has increased in my non-hearing ear"; LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (non-serious), outcome "unknown", described as "ability to care for myself has been significantly diminished"; FEELING ABNORMAL (non-serious), outcome "recovering", described as "brain fog". The patient underwent the following laboratory tests and procedures: ME/CFS: (2007) Positive. Therapeutic measures were taken as a result of depression, loss of personal independence in daily activities, feeling abnormal.  Clinical course: The patient recevied first Pfizer vaccine on 27Jan2021 and second shot on 17Feb2021, the patient did not initially notice any significant symptoms other than arm soreness, although she did experience as significant increase in her anxiety and depression. As the time went on, however, she began noticing that the symptoms of both illnesses were worsening (Some seen to be Lyme specific, others common to both Lyme and ME/CFS). In addition, she began experiencing more frequent crashes/PEM (post exertional malaise), the debilitating effect of any type of over exertion related to my ME/CFS. They were debilitating enough that she needed to stop working as a sub almost entirely - only about five days the entire school year. The lack of income has forced her to tap what little savings she have set aside for retirement to supplement my SSDI payments (plus charges on credit cards) to maintain a simple lifestyle. These symptoms also worsened after being vaccinated: TMJ arthritis, degenerative disc disease (neuropathy in my right foot) and arthritis in her thumbs and fingers and shoulders. The tinnitus has increased in her non-hearing ear, and she have lost 30% hearing in her hearing ear, which will required her to get a hearing aid. At times her ability to care for herself has been significantly diminished. On some occasions, she was not able to drive and get medication or go to the grocery store. As a result, she had to cancel various appointments, a visit with her son in another state and many get to gathers with friends- she still can't plan with any degree of certainly! she also had to stop my volunteer work with favorite non-profit since the crashes came too often and were too intense. The patient began LDN (low dose naltrexone) in the middle of Mar2022 and noticed immediate improvement in her depression, stamina, and brain fog, although it does not prevent a crash. She should still practice pacing. The patient began at a dose of 1.5 mg and have titrated down to 0.1 mg and am now trying to slowly work back up to what she understand is a more therapeutic dose. She was learning that this drug must be adjusted to each individual and requires some significant time to determine the correct dosage and time of day to take it. it is her hope that there can be research to how LDN may help the "long haulers" (those of us with post COVID 19, with me/CFS, Lyme disease, multiple sclerosis or any other auto immune illnesses).  The information on the batch/lot number for BNT162b2 has been requested and will be submitted if and when received.; Sender's Comments: Linked Report(s) : US-PFIZER INC-202201192057 Same patient, vaccine and events, different dose number;