Left tip of nose has an intermittent tickle/tingling which is annoying; Lips have intermittent tingling; Slight numbness (like weakened muscle) in left cheek of face; Massive migraine; Body aches /Achiness; Tiredness; Fever; Migraine Headache; Tingling on the left side of the face / tingling sensation; Numbness on the left side of the face from the mouth to the eye to nose; Back pain; This spontaneous case was reported by a consumer (subsequently medically confirmed) and describes the occurrence of MIGRAINE (Migraine Headache), PARAESTHESIA (Tingling on the left side of the face / tingling sensation), HYPOAESTHESIA (Numbness on the left side of the face from the mouth to the eye to nose), BACK PAIN (Back pain) and MIGRAINE (Massive migraine) in a 58-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 007C21A and 016B21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     Concurrent medical conditions included Penicillin allergy. No medical history was provided by reporter.  No concomitant medication reported.    On 27-Mar-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 24-Apr-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 26-Apr-2021, the patient experienced MIGRAINE (Migraine Headache), PARAESTHESIA (Tingling on the left side of the face / tingling sensation), HYPOAESTHESIA (Numbness on the left side of the face from the mouth to the eye to nose), BACK PAIN (Back pain), MYALGIA (Body aches /Achiness), FATIGUE (Tiredness) and PYREXIA (Fever). On 24-May-2021, the patient experienced MIGRAINE (Massive migraine). On 02-Jun-2021, the patient experienced PARAESTHESIA (Left tip of nose has an intermittent tickle/tingling which is annoying), PARAESTHESIA ORAL (Lips have intermittent tingling) and HYPOAESTHESIA (Slight numbness (like weakened muscle) in left cheek of face). The patient was treated with PARACETAMOL (TYLENOL) for Fever, Tiredness and Ache, at a dose of 1 dosage form and ACYCLOVIR [ACICLOVIR] at a dose of 800 mg three times a day. On 29-Apr-2021, BACK PAIN (Back pain), MYALGIA (Body aches /Achiness), FATIGUE (Tiredness) and PYREXIA (Fever) had resolved. At the time of the report, MIGRAINE (Migraine Headache), PARAESTHESIA (Tingling on the left side of the face / tingling sensation), HYPOAESTHESIA (Numbness on the left side of the face from the mouth to the eye to nose), MIGRAINE (Massive migraine), PARAESTHESIA (Left tip of nose has an intermittent tickle/tingling which is annoying), PARAESTHESIA ORAL (Lips have intermittent tingling) and HYPOAESTHESIA (Slight numbness (like weakened muscle) in left cheek of face) had not resolved.        For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown), the reporter did not provide any causality assessments.   No concomitant medications were provided. Action taken with mRNA-1273 in response to the events was not applicable.   Most recent FOLLOW-UP information incorporated above includes: On 02-Jun-2021: Follow-up information received on 02-JUN-2021 contains significant information: Added patient demographics, lot number and site of vaccine administration, treatment medication (Acyclovir). New events "Left tip of nose tingling", "Slight numbness in left cheek of face" and "Lips have intermittent tingling' were added. The outcome of the events (tingling on the left side of face/ tingling sensation, numbness on the left side of the face from mouth to eye) changed from unknown to not resolved.