Tired; Little headache; This is a spontaneous report received from a contactable reporter(s) (Nurse). The reporter is the patient.  A 64-year-old female patient received BNT162b2 (BNT162B2), on 18Feb2021 as dose 1, single (Lot number: EN6201), in left arm and on 11Mar2021 as dose 2, single (Lot number: EN6203) at the age of 64 years, in left arm for covid-19 immunisation. The patient's relevant medical history included: "Melanoma right eye had radiation" (unspecified if ongoing), notes: Melanoma right eye had radiation; "Ablation" (unspecified if ongoing), notes: Ablation; "Thyroid nodules" (unspecified if ongoing), notes: Thyroid nodules; "AFib" (unspecified if ongoing); "Right frontal stroke" (unspecified if ongoing), notes: Right frontal stroke/Because she had a stroke; "GERD" (unspecified if ongoing); "Hypertension" (unspecified if ongoing). Concomitant medication(s) included: CRESTOR taken for cerebrovascular accident, start date: 2016; PEPCID [FAMOTIDINE] taken for gastrooesophageal reflux disease; AVASTIN [ATORVASTATIN CALCIUM] ophthalmic taken for malignant melanoma; TRIESENCE; DIOVAN taken for hypertension, start date: 2021. Vaccination history included: Shingles (AE(s) following prior vaccinations: the only one was shingles, she got a fever and chills and body aches), administration date: 2020, for Immunization, reaction(s): "Chills", "Body aches", "Fever". The following information was reported: FATIGUE (non-serious), outcome "unknown", described as "Tired"; HEADACHE (non-serious), outcome "unknown", described as "Little headache". Relevant laboratory tests and procedures are available in the appropriate section.  Additional Information: Caller stated she had the 2 Pfizer vaccines, caller stated that with the first 2 she hardly had anything, a little headache and tired. Stated that she did have thyroid nodules and gets sonograms every year for that. Stated she has had this for years. Stated she saw an endocrinologist that had her see ENT and he sent her for a sonogram of her neck and they did see nodules there. Caller stated the weird thing is they have been consistent for the past 2 months and are staying swollen and tender in that area. Stated she noticed it as she sleeps on that side and her neck was hurting there all the time. Stated she has a problem with her eye on the other side and was not to sleep on the right side as she had melanoma in her right eye and had radiation and gets shots every month. Caller relays it's not tremendous, it's not really big but it's concerning. Stated the doctor told her to keep surveilling it a couple times a week and make sure it's not getting bigger. Caller stated it was not going away. Stated that the ENT said they have seen a few women with the same thing, it tracks where the shot is given with lymph node enlargement. Stated her concern was she would like to get a booster but she was afraid and her regular doctor said not to get it. Stated she was afraid to get it. Stated she has read that people have that in the literature and she got concerned that it's constant and it's not going away. Stated she has to go out of the country for a wedding and wants to get the booster but she is afraid. Caller stated her son was getting married and she wanted to get the booster and her doctor said he didn't think she should get it and she is hesitant.  No follow-up attempts are possible. No further information is expected.