I started developing hives on my forearms.; the swelling came back full force; redness on swollen skin areas; progressing inflammation everyday different; swollen lips; muscle under my thumb, palm side swollen; hands swollen/ forearms swollen, swelling on finger tips, feet; itching on the swollen skin; Throat swelling; further swelling on face; swollen eye lids at night; welts on both forearms; This spontaneous case was reported by a consumer and describes the occurrence of ERYTHEMA (redness on swollen skin areas), INFLAMMATION (progressing inflammation everyday different), LIP SWELLING (swollen lips), MUSCLE SWELLING (muscle under my thumb, palm side swollen) and PERIPHERAL SWELLING (hands swollen/ forearms swollen, swelling on finger tips, feet) in a 41-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 005C21A and 040B21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     Concurrent medical conditions included Allergy to chemicals (Shampoo: Burning of the scalp/ear  Polycrylic : swelling around the eyes/face), Blood pressure high and Anxiety. Concomitant products included SERTRALINE HCL for Anxiety, BISOPROLOL for Blood pressure.   On 13-Apr-2021 at 6:00 PM, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 11-May-2021 at 6:00 PM, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 06-Jun-2021, the patient experienced ERYTHEMA (redness on swollen skin areas), MUSCLE SWELLING (muscle under my thumb, palm side swollen), PRURITUS (itching on the swollen skin), PHARYNGEAL SWELLING (Throat swelling) and SWELLING OF EYELID (swollen eye lids at night). 06-Jun-2021, the patient experienced INFLAMMATION (progressing inflammation everyday different), LIP SWELLING (swollen lips), PERIPHERAL SWELLING (hands swollen/ forearms swollen, swelling on finger tips, feet) and SWELLING FACE (further swelling on face). 06-Jun-2021, the patient experienced URTICARIA (welts on both forearms). On 01-Oct-2021, the patient experienced SWELLING (the swelling came back full force). On an unknown date, the patient experienced URTICARIA (I started developing hives on my forearms.). The patient was treated with PREDNISONE ACETATE (PREDNISONE [PREDNISONE ACETATE]) from 14-Sep-2021 to 28-Sep-2021 at a dose of 10/50 mg,Daily for two weeks until weaned off; LORATADINE (CLARITIN [LORATADINE]) from 05-Aug-2021 to 01-Sep-2021 at a dose of daily for few weeks; CETIRIZINE HYDROCHLORIDE (ZYRTEC [CETIRIZINE HYDROCHLORIDE]) from 05-Aug-2021 to 01-Sep-2021 at a dose of Daily for weeks and DIPHENHYDRAMINE HYDROCHLORIDE (BENADRYL [DIPHENHYDRAMINE HYDROCHLORIDE]) from 05-Aug-2021 to 01-Sep-2021 at a dose of Daily for few weeks. At the time of the report, ERYTHEMA (redness on swollen skin areas), INFLAMMATION (progressing inflammation everyday different), LIP SWELLING (swollen lips), MUSCLE SWELLING (muscle under my thumb, palm side swollen), PERIPHERAL SWELLING (hands swollen/ forearms swollen, swelling on finger tips, feet), PRURITUS (itching on the swollen skin), PHARYNGEAL SWELLING (Throat swelling), SWELLING FACE (further swelling on face), SWELLING OF EYELID (swollen eye lids at night), URTICARIA (welts on both forearms), URTICARIA (I started developing hives on my forearms.) and SWELLING (the swelling came back full force) outcome was unknown.        For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown), the reporter did not provide any causality assessments.   Patient reported that Labwork was done but unsure of what testing was done, One test shows inflammation within patient's body, unsure of name of test.  Treatment medication included Benadryl. Type of facility was Fairgrounds   Most recent FOLLOW-UP information incorporated above includes: On 05-Oct-2021: Significant follow up received. Updated patient's demographics, patients relevant history. Added concomitant and treatment medications. Updated 1st dose details and added new events.