she believes the vaccine is completely interfering with her estrogen replacement therapy, Climara; She has been crying; throbbing headache; It was severe pressure all over her forehead; severe anxiety; insomnia/ can't sleep; This is a spontaneous report from a Pfizer sponsored program. A non-contactable consumer (patient) reported that, A 40-year-old female patient received bnt162b2 (PFIZER-BIONTECH COVID-19 mRNA VACCINE; Solution for injection, Batch/Lot number was not reported), dose 1 via an unspecified route of administration on an unspecified date as a DOSE 1, SINGLE for covid-19 immunisation; estradiol (CLIMARA [ESTRADIOL]), route of administration, start and stop date, batch/lot number and dose were not reported for oestrogen replacement therapy. The patient's medical history included oestrogen replacement therapy from an unknown date and unknown if ongoing. vaccine was completely interfering with her estrogen replacement therapy, Climara , oophorectomy from an unknown date and unknown if ongoing. She was having menopause symptoms. She stated she was only 40 but does not have ovaries because they were removed, she had oestrogen deficiency from an unknown date and unknown if ongoing reported as, depleted of estrogen. The patient's concomitant medications were not reported. It was reported that, Patient just received the first dose of the vaccine 9 days ago. The reported stated she was very upset and swore a little bit. The reported said that she believes the vaccine is completely interfering with her estrogen replacement therapy, Climara (the caller would not verify the spelling of the medication because her brain was not working). She was having mesopause symptoms. She stated she is only 40 but does not have ovaries because they were removed. She has been crying 24/7 and for her that always happens when she has low estrogen. She has had a throbbing headache. She had a headache the first night for 2 days and it went away and came back. It was too long. It was severe pressure all over her forehead. She did not have this kind of a headache unless she is completely depleted of estrogen. This headache was not severe, but it is constant. She stated why was she not informed of this? It is all over the internet, but she was told not to believe that. She was also having severe anxiety and insomnia/ can't sleep, it was like the estrogen was not working. She stated there was anxiety medication she can take but there are side effects to that too and she did not like taking them. She can't be on anxiety pills 24/7 because that makes her sick too. She stated that there were people reporting that the Covid vaccine interferes with the menstrual cycle, this was doing something to the hormones or hormone receptors or something. There were lots of people online talking about long term side effects that were chalked up to be anxiety. She stated she was not taking this vaccine again. She stated it was pure poison. She stated this better go away or else she will sue us. She stated she can't tolerate it. Additionally, she stated she probably had Covid last year. She wanted to know how long her headache will last. Where is the information on these side effects? The action taken in response to the events for estradiol was unknown. Outcome of all the events were unknown.  No follow-up attempts are possible; information about lot/batch number cannot be obtained.