4th dose was given on 01 Nov2021; seizures; Weakening of muscles/paralyzing effects of their muscles/muscle collapsing; Weakening of muscles/paralyzing effects of their muscles/muscle collapsing; Sweating; Overheating/fever; Still having muscle fatigue collapses; Muscle tightening; muscle contractions; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP) from medical information team. The reporter is the patient.  An adult female patient received bnt162b2 (BNT162B2), administered in arm right, administration date 01Nov2021 (Lot number: 30135BA) as dose 4, single for covid-19 immunisation. Relevant medical history included: "Autoimmune disorder resulted from an exposure to chemicals." (unspecified if ongoing), notes: Autoimmune disorder resulted from an exposure to chemicals. Concomitant medication(s) included: THYROXINE taken for autoimmune disorder, start date: 19May2018. Vaccination history included: Bnt162b2 (Dose1, Lot EM6203, expiration is unknown. Injected in right arm.), administration date: 19Mar2021, for COVID-19 Prevention, reaction(s): "Aching arm", "My muscles gave out which continued until Oct of last year/muscle weakness", "paralyzing"; Bnt162b2 (Dose2, Lot ER8727, expiration is Unknown. Injected in Right arm.), administration date: 09Apr2021, for COVID-19 Prevention, reaction(s): "Aching arm", "My muscles gave out which continued until Oct of last year/muscle weakness", "Paralyzing"; Bnt162b2 (Dose3, Lot 30135BA, expiration is unknown. Injected in right arm.), administration date: 21Oct2021, for COVID-19 Prevention, reaction(s): "Weakening of muscles/paralyzing effects of their muscles/muscle collapsing", "2 days after started falling to the ground again", "More sweating", "Fatigue", "Collapsing down". The following information was reported: EXTRA DOSE ADMINISTERED (medically significant) with onset 01Nov2021, outcome "unknown", described as "4th dose was given on 01 Nov2021"; SEIZURE (medically significant) with onset 2021, outcome "unknown", described as "seizures"; PARALYSIS (medically significant), MUSCULAR WEAKNESS (non-serious) all with onset 2021, outcome "unknown" and all described as "Weakening of muscles/paralyzing effects of their muscles/muscle collapsing"; HYPERHIDROSIS (non-serious) with onset 2021, outcome "unknown", described as "Sweating"; PYREXIA (non-serious) with onset 2021, outcome "unknown", described as "Overheating/fever"; MUSCLE FATIGUE (non-serious) with onset 2021, outcome "not recovered", described as "Still having muscle fatigue collapses"; MUSCLE TIGHTNESS (non-serious) with onset 2021, outcome "unknown", described as "Muscle tightening"; MUSCLE CONTRACTURE (non-serious) with onset 2021, outcome "unknown", described as "muscle contractions". Therapeutic measures were taken as a result of muscular weakness, hyperhidrosis, pyrexia, muscle fatigue. Clinical course: She mentioned she got another two extra shots, so 4 shots in total of the Pfizer COVID 19 vaccine. She also ended up sick again on Dec2021, due to COVID, and described symptoms as being massively bad. He thinks she is referring to the COVID. She also mentioned that her main concern was weakening of muscles. She, as well as associates, were self quarantining and could hardly go to the bathroom due to the paralyzing effects of their muscles. She had been given astronomic amounts of magnesium and plenty of potassium as a muscle relaxant. She also had a bacterial infection, but is not sure if it was after the first two initial shots or after the last two shots. At the end of Oct2021, 2 days after, it looks like she started feeling sweating and muscle tightening. Reporter clarified information above. She said it was a few days instead of a few months when her muscles became weak.  She also clarified the bacterial infection mentioned above was the COVID virus. She stated that when you have a vaccination, they advise you to rest for a couple of days and she went out on 3rd day and muscles completely seized and went into cramps and fell out from under her. That continued after she pushed herself after a few blocks.  It went away until she got further on her walk until it would collapse.  She took her vaccination and after 2 days of resting, she had muscle collapsing and that kept going until end of Dec2021, when she caught COVID. She later stated that she caught COVID virus in 01Jan2022. After she came down with COVID virus, she said she can hardly walk from her apartment to her car. She took a double vaccination end of Oct2021, she took 2 days rest and then went out walking and had the same thing again. She later clarified that the 3rd vaccine was on 21Oct2021, and the 4th was given on 01Nov2021. She has associates that got it and had muscle contractions and seizures. It got better as the months go on and by 01Oct2021, she was able to go from 2 blocks with fatigue to walking 3/4 of a mile before she got fatigued. By the end of Oct2021, she went in and had another vaccination. These are done in two weeks separation. She is going back and having the secondary shot in between.  Unable to clarify this statement. It started out with the same problem and started to get better and then she got COVID. She also started sweating, and overheating and still having muscle fatigue collapses. She knows that part of the vaccination syndrome is that the day after receiving, you have a fever and start sweating. You don't think it will occur later after you exercise. She does not know why she specifically has it, and knows of a few other people that have it, but they would need to make their own report. They have fatigue of tendons and muscles, and it gets worse when you get COVID virus. She does not know if it will be better in a few months. She has a neighbor that has the same thing and she said she does not know if he has the autoimmune that she does that will be open to the same syndrome. He may not have the same autoimmune with her.