Muscle pain and aches; Injection site swelling; Injection site redness; Injection site pain; Tiredness; Headache; Fever 99.6; Throat burning; Chills; she couldn't sleep; This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP). The reporter is the patient.  A 70-year-old female patient received BNT162b2 (BNT162B2), on 14Apr2022 at 10:00 as dose 4 (booster), single (Lot number: FK9894) at the age of 70 years, in left arm for covid-19 immunisation. The patient's relevant medical history included: "Root canal" (unspecified if ongoing). Concomitant medication(s) included: AMOXICILLIN taken for root canal infection, start date: 24Mar2022, stop date: 31Mar2022. Vaccination history included: BNT162b2 (Unspecified Pfizer vaccine first booster vaccine, Date given: 05Oct2021, Manufacturer: Pfizer, Lot: 30135BA pharmacy handwriting is weird), administration date: 05Oct2021, when the patient was 69-year-old, for Covid-19 immunization, reaction(s): "No adverse reaction"; BNT162b2 (Unspecified Pfizer vaccine second vaccine, Date given 23Feb2021, Manufacturer: Pfizer, Lot: EN6202, .), administration date: 23Feb2021, when the patient was 69-year-old, for Covid-19 immunization, reaction(s): "No adverse reaction"; BNT162b2 (Unspecified Pfizer vaccine first vaccine, Manufacturer: Pfizer, date given: 06Feb2021, Lot EM9810), administration date: 06Feb2021, when the patient was 69-year-old, for Covid-19 immunization, reaction(s): "No adverse reaction".  The following information was reported: CHILLS (non-serious) with onset 14Apr2022, outcome "unknown"; PYREXIA (non-serious) with onset 14Apr2022, outcome "recovered" (Apr2022), described as "Fever 99.6"; HEADACHE (non-serious) with onset 14Apr2022, outcome "unknown"; INJECTION SITE PAIN (non-serious) with onset 14Apr2022, outcome "recovering"; INJECTION SITE ERYTHEMA (non-serious) with onset 14Apr2022, outcome "recovering", described as "Injection site redness"; INJECTION SITE SWELLING (non-serious) with onset 14Apr2022, outcome "recovering"; MYALGIA (non-serious) with onset 14Apr2022, outcome "recovered" (Apr2022), described as "Muscle pain and aches"; THROAT IRRITATION (non-serious) with onset 14Apr2022, outcome "unknown", described as "Throat burning"; FATIGUE (non-serious) with onset 14Apr2022, outcome "recovered" (Apr2022), described as "Tiredness"; INSOMNIA (non-serious) with onset 14Apr2022, outcome "unknown", described as "she couldn't sleep". Relevant laboratory tests and procedures are available in the appropriate section. Therapeutic measures were taken as a result of myalgia, injection site swelling, injection site erythema, injection site pain, fatigue, headache, pyrexia, throat irritation, chills, insomnia.  Additional Information: She went to have second booster yesterday, 14Apr2022. She went to (facility name withheld) and she had very strong reaction. She has never had this before. With her first, second, and first booster shot it was mild. Then caller clarified she never had reaction with first, second, or first booster. She said this is her fourth shot. She is ok and this morning her fever was back to normal temperature and not life threatening. She has tiredness, muscle aches, muscle pain, injection site has swelling and redness and pain. She is planning on traveling and she said she better do for a layer of protection. She should have never had strong reaction and yesterday was pretty bad and she couldn't sleep. She took 2 Tylenol and she usually doesn't take anything. She had a headache and muscle pain, fever, injection site redness and pain. All the CDC reported symptoms she had them all. No stomach pain. All symptoms started after 8:30 or 8:00, around the time after dinner. She had no problem and then after cleaning the kitchen she realized. Started with injection site pain. Then she felt like she had a fever so she took her fever and her fever was 99.7. Her temperature is normally pretty low 96.8 to 97.2. She had a two degrees fever and felt horrible. Yesterday it was 99.6. She felt like her throat burning. She said it started around 8 to 830 pm. She had shot at 10:00 am and this started after 10 hours or something like that. She slept 10 hours and symptoms improved this morning. Got up to get water at 800. She took temperature and was back to normal at 97.3. She has no chills and no fever and she does not have those things. She said yesterday a little bit associated with the fever. She is improving and doesn't feel like she needs to report to a doctor. It is nothing alarming. Muscle pain and tiredness ongoing and fever is gone. Treatment: Just Tylenol. Tylenol: dose was normal from drug store. She thinks it is 500mg each and she took 2, so 1000mg extra strength capsule. She took Tylenol yesterday 14Apr2022 around 900, 930, or 1000 and she went to bed early because she felt sick. She said it's before bed time and she better take something. She took amoxicillin from 24Mar2022 to 31Mar2022 for a root canal. Took it for one week or 7 days. She finished with no problem. This was 14 to 15 days apart.  Follow-up attempts are completed. No further information is expected.