mild fatigue; brief unusual nerve pain; burning pain in my knee area; pain is happening beneath the skin of the knees / related to the skin above the knee; feel inflamed; they burn / burning joint pain/burning sensation in joints/burning knee pain, he cannot kneel; his elbows and both knees are sensitive; tingling sensation going down left; sore arm at the injection site; This case was reported by a other health professional and described the occurrence of injection site pain in a 60-year-old male patient who received Herpes zoster (Shingrix) for prophylaxis.   Concomitant products included ibuprofen (Motrin).   On 29th October 2021, the patient received the 1st dose of Shingrix (intramuscular). In October 2021, less than a week after receiving Shingrix, the patient experienced tingling sensation. On 29th October 2021, the patient experienced injection site pain. On 10th November 2021, the patient experienced sensitive skin. On 11th November 2021, the patient experienced burning sensation in joints. On an unknown date, the patient experienced fatigue, nerve pain, pain burning, skin pain and knee arthritis. The patient was treated with naproxen (Naprosyn). On an unknown date, the outcome of the injection site pain, nerve pain and tingling sensation were recovered/resolved and the outcome of the fatigue, knee arthritis and sensitive skin were unknown and the outcome of the pain burning, skin pain and burning sensation in joints were not recovered/not resolved.   The reporter considered the injection site pain to be related to Shingrix. It was unknown if the reporter considered the fatigue, nerve pain, pain burning, skin pain, burning sensation in joints, knee arthritis, sensitive skin and tingling sensation to be related to Shingrix.  Additional case details were provided as follows: The case was reported by the patient. The patient received the 1st dose of Shingrix in left arm, initial side effects were mild and unexpected, about 8 hours after the Shingrix injection patient's arm was sore at the injection site but resolved in a few days. Also had mild fatigue and a brief, unusual nerve pain that went down left leg to foot (which went away completely after it occurred). However, after 10-12 days of receiving the 1st dose of Shingrix, the patient started to develop a burning pain in right knee area.  This burning pain occurred when the patient bent knee and touched the floor, leaning on knee. This pain had continued, remains pronounced, and did not go away.  It feels like the pain was happening just beneath the skin of the knees.  Both knees appear to be affected, but it was worse on his right knee.  It feels like it was related to the skin above the knee, as the knee joint itself does not hurt.  About 24 to 36 hours after the Shingrix injection he noticed a tingling sensation that went all the way down his left leg to his foot and then went away in a few minutes.  About 5 days ago from the date of reporting on 10th November 2021 both his elbows and both knees were sensitive. The patient had a burning sensation in his right knee if he rubs the right knee it was fine, but if he touches it with a piece of fabric it burns and feel inflamed, could not kneel his right knee on the ground because of the painful burning sensation. It was much more pronounced on the right knee. The reporter asked was this burning knee pain related to the Shingrix vaccine and if so, when should he expect it to go away.  The patient had taken Motrin and Naprosyn to take the edge off his right knee.  Also asked did this burning joint pain have nothing to do with Shingrix, the patient never experienced this before taking Shingrix. The patient would appreciate receiving any documentation, research or information if GlaxoSmithKline have on this possible side effect. The reporter was waiting to hear from his HCP to see if this might be related to shingles. The reporter did not consent to follow-up.; Sender's Comments:  US-GLAXOSMITHKLINE-US2021235330:Same reporter, FU1 - Deleted