The caller said that the doctor advised her to get the second dose and the symptoms got worse.; inflammation; fatigue / exhaustion; massive hair loss; discomfort in her eyes; hear clinks and clanks all over her body. It happens in her legs, arms, and shoulders/could hear clinks and clinks like her body is clinking; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP) from medical information team. The reporter is the patient.  A 40 year-old female patient received bnt162b2 (BNT162B2), administered in arm left, administration date 29Apr2021 (Lot number: EW0171) at the age of 40 years as dose 2, single for covid-19 immunisation. The patient had no relevant medical history. Concomitant medication(s) included: ZINC taken for supplementation therapy (ongoing); VITAMIN D NOS taken for supplementation therapy (ongoing). Vaccination history included: Bnt162b2 (Dose:1, one of her feet is cold as a popsicle but it was not cold to the touch/one of her feet that was frozen like a popsicle), administration date: 08Apr2021, when the patient was 40 years old, for COVID-19 Immunization, reaction(s): "one of her feet is cold as a popsicle but it was not cold to the touch/one of her feet that was frozen like a popsicle", "here were also tightness, stiffness and soreness with pain and discomfort in her lower leg and knees that also led to pins and needles in her leg that "felt like bugs"/tightness in her lower legs in her knees and below her knees", "here were also tightness, stiffness and soreness with pain and discomfort in her lower leg and knees that also led to pins and needles in her leg that "felt like bugs"/had tightness, stiffness, soreness, and pain and discomfort", "here were also tightness, stiffness and soreness with pain and discomfort in her lower leg and knees that also led to pins and needles in her leg that "felt like bugs"", "here were also tightness, stiffness and soreness with pain and discomfort in her lower leg and knees that also led to pins and needles in her leg that "felt like bugs"", "here were also tightness, stiffness and soreness with pain and discomfort in her lower leg and knees that also led to pins and needles in her leg that "felt like bugs"", "soreness, and pain", "this led to pins and needles in her legs like she had jumping bugs on her legs", "cold feeling in her feet was Raynaud's". The following information was reported: INFLAMMATION (medically significant) with onset Sep2021, outcome "unknown", described as "inflammation"; FATIGUE (non-serious) with onset Sep2021, outcome "unknown", described as "fatigue / exhaustion"; ALOPECIA (non-serious) with onset Sep2021, outcome "unknown", described as "massive hair loss"; OCULAR DISCOMFORT (non-serious) with onset Sep2021, outcome "unknown", described as "discomfort in her eyes"; HYPOACUSIS (non-serious) with onset Sep2021, outcome "unknown", described as "hear clinks and clanks all over her body. It happens in her legs, arms, and shoulders/could hear clinks and clinks like her body is clinking"; CONDITION AGGRAVATED (non-serious), outcome "unknown", described as "The caller said that the doctor advised her to get the second dose and the symptoms got worse.". The events "inflammation", "fatigue / exhaustion", "massive hair loss", "discomfort in her eyes", "hear clinks and clanks all over her body. it happens in her legs, arms, and shoulders/could hear clinks and clinks like her body is clinking" and "the caller said that the doctor advised her to get the second dose and the symptoms got worse." were evaluated at the physician office visit. The patient underwent the following laboratory tests and procedures: electromyogram: normal, notes: She had a EMG and it was normal; laboratory test: negative; magnetic resonance imaging: negative; ultrasound scan: negative; x-ray: negative.  The clinical course was reported as follows: Around Sep2021, she got whole body symptoms. She had exhaustion, fatigue, massive hair loss, and discomfort in her eyes. She went back and saw a chiropractor and they said she had inflammation. She had a EMG and it was normal. They are going to do a skin pinch biopsy to see if there is damage to the micro nerves. She has another rheumatology appointment to see if there is any change in her labs too.  The latest symptom she had is that she can hear clinks and clanks all over her body. It happens in her legs, arms, and shoulders. She said that this started in early Sep2021.  She said that it has to be a response to the vaccine. She said that her doctor said that the odds are very high that it is because of the vaccine.    Follow-up attempts are completed. No further information is expected.; Sender's Comments: Linked Report(s) : US-PFIZER INC-202101731350 Same reporter/patient/drug, different dose/event