5 minutes after receiving the COVID-19 Vaccine shot, she had generalized itching allover her body; Her heart rate was in the 140s/tachycardia; She noticed the COVID-19 Vaccine injection site had a red welt; She developed a rash on her torso first, and then she developed a rash on her neck and face; Shortness of breath; Allergic reaction; Injection site rash; This is a spontaneous report from a contactable consumer (patient). A 37-year-old female patient received the first dose of BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE; lot: EL8982, expiry: unknown), via an unspecified route of administration in the left arm on 29Jan2021 14:25 at a single dose for COVID-19 immunization at a hospital. Medical history included asthma from 2001. The patient also had history of anaphylactic reactions to bee stings and strawberries. She said her allergist tested her further and told her she has severe allergies to tomatoes and to not eat tomatoes anymore. She said she has allergies to sulfa antibiotics. She said about 10 years ago was the last time she took a sulfa antibiotic and she had hives. She said her allergist recommended she avoid sulfa antibiotics. Concomitant medication included salbutamol sulfate (PROAIR HFA; lot: DAE36A, expiry: May2021; NDC Number: 59310-5779-22) from 2001 and ongoing for asthma. The patient has no prior vaccinations within 4 weeks. The patient received her first COVID-19 vaccine shot on Friday, 29Jan2021, and had an allergic reaction (Jan2021). 5 minutes after receiving the COVID-19 vaccine shot (29Jan2021 14:30), she had generalized itching all over her body, she then had tachycardia. She was administered some medication by the staff at the site where the COVID-19 vaccine was being administered, but her allergic reaction kept progressing. She developed a rash on her torso first, and then she developed a rash on her neck and face. She then developed shortness of breath. She was brought to the hospital's Emergency Room for further treatment. She was given the oral medications Pepcid 40mg, Claritin (dose unknown), and Benadryl 25mg at the location where the COVID-19 vaccines were being administered. When she started to experience shortness of breath, she used her own personal Albuterol inhaler. When she was in the Emergency Room, she was given a shot of Epinephrine .4ml at 15:16, and a dose of Benadryl 25mg IV at 15:10. She was observed in the Emergency Room for a couple of hours and then discharged. The patient was also given a steroid dose pack for her itching, clarified as Medrol 4mg tablets. She said she is titrating down the amount of Medrol 4mg tablets (NDC Number: 59762-4440-2, Lot Number: DM4008, Expiration Date: Oct2022). The patient reported that her itching has improved, but she still has a rash on her torso. She noticed the COVID-19 vaccine injection site had a red welt first on 29Jan2021, clarifying the vaccine injection site has a rash now (2021). She said she was put on a heart monitor when her allergic reaction began to progress, and her heart rate was in the 140s, clarifying she has a heart rate of 145. She said at the time she was discharged from the Emergency Room; her heart rate was 115. She stated she has had to use her Albuterol inhaler throughout the weekend, which is more so than usual, but it is currently allergy season where she lives in. She had no blood work performed while she was being treated in the Emergency Room but did have an EKG to be on the safe side, along with monitoring of her vital signs. The outcome of the events generalized itching, rash, and shortness of breath was recovering; event tachycardia was recovered on 29Jan2021; event vaccination site rash was not recovered while the other events was unknown.