swollen ankle on the right side; on the inside of her arms it looked like blisters; rash bothered her and it was unnerving; she first saw the rash under the band aid at the injection site; rash on / abdomen / feel the rash moving / waist / thighs / legs / knees / arms / hands / nerve endings / left breast / traveled up /left nipple area / down the left thigh / waistband area / belly button; felt it on her thighs with itching; rash looked like sunburn; feeling tingly on her skin and chest; arm became / swollen; arm became red; arm became / hard; left arm was sore to the touch for days; received / first dose/ at the end of Spring 2020 / second dose / 12/23/2020; This case was reported by a consumer and described the occurrence of injection site rash in a 64-year-old female patient who received Herpes zoster (Shingrix) for prophylaxis.   The patient's past medical history included drug rash (gets rashes from other medications). Previously administered products included shingrix (1st dose received at the end of Spring in 2020). Concurrent medical conditions included heart rate low.   On 23rd December 2020, the patient received the 2nd dose of Shingrix. On 23rd December 2020, less than a day after receiving Shingrix, the patient experienced pain in arm and drug dose administration interval too long. On 24th December 2020, the patient experienced swelling arm, erythema of extremities, induration and tingling skin. On 25th December 2020, the patient experienced injection site rash, rash, itchy rash and red rash. On 26th December 2020, the patient experienced blister and discouragement. On 27th December 2020, the patient experienced ankle swelling. The patient was treated with benadryl (nos) (Benadryl Cream). On 28th December 2020, the outcome of the ankle swelling was recovered/resolved. On an unknown date, the outcome of the injection site rash, pain in arm, swelling arm, erythema of extremities, induration, rash, tingling skin, itchy rash, red rash, blister, discouragement and drug dose administration interval too long were unknown.   It was unknown if the reporter considered the injection site rash, pain in arm, swelling arm, erythema of extremities, induration, rash, tingling skin, itchy rash, red rash, blister, discouragement and ankle swelling to be related to Shingrix.  Additional details were reported as follows: The patient was fine at night of vaccination however, her left arm was sore to the touch for days. On next day after vaccination arm became red, swollen and hard. On night of 26th December 2020, she was felt tingly on her skin and chest. On Christmas morning (25th December 2020) and she had a rash on her abdomen so she used extra strength Benadryl cream and she felt better. By lunch that day she could felt the rash moving around her waist so she used more Benadryl cream. She then felt it on her thighs with itching and the rash got on both her legs past her knees on her arms and hands. On 26th December 2020, rash looked like was going to blister on her left wrist but she ate well, drank water and used more lotion and cream and it never got worse and it got better. She could feel the rash running under her skin in her nerve endings. The patient had low heart rate and is not immunocompromised and felt that she was very healthy which was why she was surprised she got a rash. The patient claimed that she first saw the rash under the band aid at the injection site on her left arm, however, band aids will bother her sometimes. On 25th December 2020,  rash started on the left side and a little on the left breast and traveled up onto the left nipple area and traveled across the abdomen down the left thigh, then moved to the waistband area and in her belly button and on her side and back and by the afternoon the rash looked like sunburn. On 26th December 2020, rash bothered her and it was unnerving and on the inside of her arms it looked like blisters however on next day it was good. On 27th December 2020, she was baking and she had a swollen ankle on the right side which dissipated by next day. The reporter stated that swelling could be related to a lack of water, her age and being so busy on that Sunday. The reporter consented to follow up.