she has metastatic breast cancer that has spread to a lot of places an for the past 9 months; red blood cell count were low; her neutrophils were low; platelets were low; her hair was coming out a little bit at a time (2-3 hairs would come out if she ran it through her fingers)/hair loss; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP) from medical information team. The reporter is the patient.  A 73-year-old female patient received BNT162b2 (BNT162B2), on 27Jan2021 as dose 1, single (Lot number: EN5318), in left arm, on 24Feb2021 as dose 2, single (Lot number: EN6203), in left arm, on 18Aug2021 as dose 3 (booster), single (Lot number: EW0187), in left arm and on 01Jun2022 as dose 4 (booster), single (Lot number: FN2908), in left arm for covid-19 immunisation; palbociclib (IBRANCE), first regimen at 125 mg and second regimen since Jul2022 (ongoing) at 100 mg for breast cancer female. The patient's relevant medical history included: "right mastectomy" (unspecified if ongoing), notes: right mastectomy. Concomitant medication(s) included: FULVESTRANT as unk, monthly (injection once a month injection). Vaccination history included: evusheld (No NDC Lot or expiration date), administration date: 30Mar2022, when the patient was 73-year-old, for Immunization. The following information was reported: ALOPECIA (non-serious) with onset Jun2022, outcome "not recovered", described as "her hair was coming out a little bit at a time (2-3 hairs would come out if she ran it through her fingers)/hair loss"; NEOPLASM PROGRESSION (non-serious), outcome "unknown", described as "she has metastatic breast cancer that has spread to a lot of places an for the past 9 months"; RED BLOOD CELL COUNT DECREASED (non-serious), outcome "unknown", described as "red blood cell count were low"; NEUTROPHIL COUNT DECREASED (non-serious), outcome "unknown", described as "her neutrophils were low"; PLATELET COUNT DECREASED (non-serious), outcome "unknown", described as "platelets were low". Relevant laboratory tests and procedures are available in the appropriate section. The action taken for palbociclib was dosage reduced.  Additional Information: She had been on Ibrance 125mg for about 9 months. It was working great on all of her cancer. She has had very few side effects. Recently, she started with her hair coming out a little at a time. Like individual hairs, like 2-3 hairs would come out when she combs her hair or runs her fingers through her hair. Now they had reduced her to Ibrance 100mg because she had problems with her blood. She was perplexed and doctors were not concerned. They were curious as to why it was starting so late with the hair loss. She wanted to know if it was normal for it to start so late. She wanted to know if we had any information if it would start falling out a lot since it's started to come out now. Caller stated she was also on Fulvestrant. She had been vaccinated with 2 boosters of the Pfizer COVID19 vaccine and was not sure if it may be due to the vaccines as well. She had regular IV for 3 years and understands what it's like to had alopecia. When she had regular chemotherapy, her hair started coming off and she buzzed it off. With the Ibrance it was coming out a few strands at a time. Caller asked, Is it normal for it to start so late? Does that mean a lot of it will start falling out? Caller said that she does not want to see it come out and will just buzz her head if that was what was going to happen. She had both of her Pfizer vaccines and booster and does not know if there was any relationship with this and her Ibrance. She had no bad effects from the Covid shots, it was great. Weight was 245lbs because of prednisone. She had been on it for 5 years. She previously weighed 130lbs when she started Prednisone and said that she put on the weight of a entire person. NO NDC, lot, or expiration. The prednisone was in a pharmacy vial. She had seen 2 Oncologists. Dr. info was populated in the formal field. Hair was coming out which started the last week of Jun2022. It was 1-2 strands that come out all day long. It was not coming out in big clumps. She knows that hair loss was a side effect, but she thought it would be sooner than now. Even her doctor's thought it would happen sooner than this. Patint took Ibrance for 21 days, then they let your blood regenerate. The 1st time it occurred was a month ago. Her white count was critically low, and her red blood cell count and her neutrophils were low. They did not want her to restart the Ibrance and stayed off of it 14 days instead of 7. She came back to the office to get another blood test and her blood levels were the same and the doctor told her to stay off another 7 days. She came back for another blood test and her levels were all back to low. They had her restart Ibrance 125mg even though it was low. She took it for 21 days and her white counts were critically low, red blood cells and neutrophils were low, and her platelets were low which was new. They told her to come back in a week for more blood tests. There was still a problem and nothing was critical, but they were all low as of this past Thursday and they told her to restart, but at the Ibrance 100mg dose. She was going back this Wednesday to see how things were doing. Her PET scan was showing Ibrance was doing very well and keeping the cancer from spreading. Her cancer had not gone away, but it was not spreading. She had some new cancer a couple of months and that was not spreading because of Ibrance. She was on something else prior to this and was on regular chemotherapy for 3 years prior to that. In addition to her covid-19 shots she was given a shot of Evusheld. No NDC Lot or expiration date. 30Mar2022 it was received.   No follow-up attempts are possible. No further information is expected.