Arm from her elbow to her shoulder is hot; Arm / Swollen; Arm / tender/ whole arm with sharp pain; sharp pain from her elbow up to her shoulder; sharp pain from her elbow up to her shoulder; Muscle soreness; Super tired; allergic to latex; allergic to latex; received the first shot of the Bexsero series about a year ago; This case was reported by a consumer via call center representative and described the occurrence of extremities hot feeling of in a 20-year-old female patient who received Men B NVS (Bexsero) for prophylaxis.   Previously administered products included Sulfa eye drops with an associated reaction of swelling face, Sulfa drug with an associated reaction of erythema, Benadryl and Bexsero with an associated reaction of no adverse event (1st dose received about a year ago). Concurrent medical conditions included latex allergy (contact induced such as band aids and latex gloves) and sulfonamide allergy.   On 14th October 2020 10:00, the patient received the 2nd dose of Bexsero. On 14th October 2020, less than a day after receiving Bexsero, the patient experienced extremities hot feeling of, swelling arm, pain in arm, pain in elbow, shoulder pain, muscle soreness, tiredness, allergic reaction to drug excipient, contraindicated product administered and drug dose administration interval too long. The patient was treated with ibuprofen (Advil). On an unknown date, the outcome of the extremities hot feeling of, swelling arm, pain in arm, pain in elbow and shoulder pain were recovering/resolving and the outcome of the muscle soreness was not recovered/not resolved and the outcome of the tiredness, allergic reaction to drug excipient, contraindicated product administered and drug dose administration interval too long were unknown.   It was unknown if the reporter considered the extremities hot feeling of, swelling arm, pain in arm, pain in elbow, shoulder pain, muscle soreness, tiredness and allergic reaction to drug excipient to be related to Bexsero.  Additional details were provided as follows: The case was reported by the mother of patient. The age at vaccination was not reported. The patient had latex allergy that was contact induced such as band aids and latex gloves and had sulfa allergy.  The patient had blocked tear duct and sulfa eye drops were prescribed which made her whole face red and swollen. A few years later the patient got a urinary tract infection and was prescribed sulfa as a tablet and again had a reaction to it. This time her whole body was red like a sunburn and she had to take Benadryl. The patient received Bexsero vaccine and her whole arm from her elbow to her shoulder was hot, swollen, tender, and she was experiencing muscle soreness. The patient was also super tired (took naps in the afternoon and went to bed around 9). The reporter asked if there was sulfa in this vaccine. The reporter stated that reading the page, she saw that it did contain latex. The patient was allergic to latex and sulfa drugs. The reporter stated that there should be warnings to the doctors letting them know what is in the vaccines so they do not unnecessarily harm children and young adults. There were a lot of people allergic to latex and should try your best to come up with a product that did not incorporate latex. The reporter was called back and she indicated that the patient received the Bexsero at around 10 am in the morning at the pediatrician's office. The reporter said that patient's whole arm was hot with sharp pain from her elbow up to her shoulder. It was hot and tender and swollen. On the day of reporting, in the morning the patient got up to go to school and after taking Advil. She said that her arm was just a muscle ache (no longer a sharp pain) so it seemed to be resolving. The patient did not have a fever. The reporter indicated that she was surprised that this happened because it seemed like an adverse reaction more harsh than any other vaccine the patient had ever received. The patient had received the first shot of the Bexsero series about a year ago and did not have a reaction, later than the recommended interval which led to lengthening of vaccination schedule.