COVID-19 Treatment; COVID-19 Treatment; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP). The reporter is the patient.  A 70-year-old male patient received BNT162b2 (BNT162B2), on 27Jan2021 as dose 1, single (Lot number: EL9261), in left arm, on 17Feb2021 as dose 2, single (Lot number: EN6201), in left arm and on 04Oct2021 as dose 3 (booster), single (Lot number: FF2589) at the age of 69 years, in left arm for covid-19 immunisation; covid-19 vaccine mrna (mrna 1273) (MODERNA COVID-19 VACCINE), on 29Apr2022 at 15:00 as dose 4 (booster), single (Lot number: 066K21A), in left arm for covid-19 immunisation. The patient's relevant medical history included: "GERD" (unspecified if ongoing); "Occasional seasonal allergies like hay fever" (ongoing), notes: Occasional seasonal allergies like hay fever, spring to fall. Concomitant medication(s) and other medications in 2 weeks included: VITAMIN B 12 [CYANOCOBALAMIN] (ongoing); VITAMIN D 3 (ongoing); PRAVASTATIN (ongoing); TAMSULOSIN (ongoing); TRAZODONE (ongoing); PANTOPRAZOLE (ongoing); FAMOTIDINE (ongoing); FLUTICASONE taken for seasonal allergy (ongoing) and MULTIVITAMINS (ongoing). The following information was reported: VACCINATION FAILURE (medically significant), COVID-19 (medically significant) all with onset 2022, outcome "not recovered" and all described as "COVID-19 Treatment". The patient underwent the following laboratory tests and procedures: SARS-CoV-2 test: (07Aug2022) Positive, notes: I tested positive at 6 pm; (12Aug2022) Positive, notes: Last doses of Paxlovid. End of day: Tested positive; (14Aug2022) Positive, notes: End of day, test shows light line, still positive; (15Aug2022) Negative, notes: Tested again. This time negative. Feeling good; (17Aug2022) Positive, notes: Some shortness of breath, cough and runny nose return. Tested again, clearly positive. Therapeutic measures were taken as a result of vaccination failure, covid-19 which included Paxlovid from 08Aug2022 to 12Aug2022. The patient's symptoms of COVID returned and he again tested positive for COVID 5 days after the 5-days of Paxlovid. On 07Aug2022, the patient had light cough from deep in chest started in morning, runny nose in afternoon. He tested positive at 6 pm. On 08Aug2022, the patient had moderate cough, runnier nose, headache. Doctor prescribed Paxlovid and he started it by lunchtime. On 11Aug2022, the patient woke in sweat, cooled down after about an hour. Minimal cough and runny nose, but now sore throat and shortness of breath. Skin sensitive to touch as would be with flu. On 12Aug2022, the patient had sweat again and worse shortness of breath. Walking in fresh air helped, but not enough. Quarantine continued. The patient had last doses of Paxlovid. End of day, the patient tested positive. On 14Aug2022, at the end of day, test showed light line, still positive. On 15Aug2022, the patient tested again. This time negative. The patient was feeling good. On 17Aug2022, the patient had some shortness of breath, cough and runny nose returned. He tested again, clearly positive. Quarantining continued. On 18Aug2022, the patient talked to doctor. Sounded like rebound COVID. He was isolated for 5 more days.