tiny headache; Nausea; Excruciating knee pain; Swollen knee; knees almost didn't work, almost had to crawl and stayed in bed; This is a spontaneous case received from a contactable consumer(patient). A 72-year-old female patient received second dose of bnt162b2 (BNT162B2, PFIZER-BIONTECH COVID-19 VACCINE, Formulation: Solution for injection, Lot number: ER8732), via an unspecified route of administration in arm left on 26Mar2021 14:15 (age at vaccination 72-year-old) as DOSE 2, SINGLE for COVID-19 immunisation. The patient medical history included asthma from 1952 and ongoing, arthritis from 1990 and ongoing, glaucoma from 1991 and ongoing, coronary artery disease from 2015 and ongoing, stent placement in the heart from 2015 and ongoing, knee replacement in 2009 and 2016. Concomitant medications included pain medications. Historical vaccine included first dose of bnt162b2 (BNT162B2, PFIZER-BIONTECH COVID-19 VACCINE, Formulation: Solution for injection, Lot number: EN6199), via an unspecified route of administration in right arm on 05Mar2021 for COVID-19 immunisation. History of all previous immunization with the Pfizer vaccine considered as suspect (or patient age at first and subsequent immunizations if dates of birth or immunizations are not available) was reported as none. Additional administered vaccines were reported as none. Family medical history relevant to adverse event was reported as none. On 29Mar2021, the patient experienced tiny headache, nausea, excruciating knee pain. On an unspecified date in 2021, patient experienced swollen knee. Caller received second Pfizer vaccine Friday 26Mar2021 in the afternoon and three days later she had a tiny headache and nausea. Three days later went to get out of bed and her knees almost didn't work, almost had to crawl and stayed in bed. She had knee replacements in 2009 and 2016. Her knees felt as if she has had no anesthesia and she just came out of surgery. She was in excruciating pain in both knees. In terms of knee replacements, one was good and the other one was bad. Feels better while resting. The one that was good was done in 2016. It isn't quite as bad and stiff. Caller stated the other knee was in the exact kind of pain to what she felt in 2019. Clarified to the kind of pain she felt in 2009. She used to have to get cortisone shots. States it doesn't get swollen every time when she walks.  Caller said that she does not know what is wrong with her today. She said that there is something wrong with her brain and think it might be the painkillers she took last night. Last night she took the painkiller oxy-acetaminophen, but it is not working, she still feels throbbing after taking it. States this is an old medication for knee replacement and it is not potent. She had to get her glasses and magnifying glass to see the information on the bottle, she said that it is too small. The expiration date is 28Nov2017. She also states that Ibuprofen doesn't help with her symptoms. She states she had tiny headache that lasted 5 second headache at 2am on 29Mar2021. She never gets them, that's how she noticed the headache. She was in bed and getting ready to go to bathroom when she had a 3 second headache and a little nausea. She couldn't walk and she was ready to fall. She had excruciating pain with every step. One leg feels the same and is persisting. She is in bad pain and has to walk with a walker. The other knee improved to the point where she can bend it halfway, but it's swollen. Ibuprofen does not help. States the reason she was calling is to let us know that she thinks she had something that was out of the realm of muscle aches and pains. Caller asks what should she do now? Should she wait for the pain to go away? She states after that, she was going to wait a week and get the cortisone shot. She went from walking to not really being able to walk. The patient did not undergo any relevant tests. Adverse events did not require emergency room visit. The outcome of the events headache and nausea was recovered on 29Mar2021, arthralgia and joint swelling was not recovered and event (knees almost didn't work, almost had to crawl and stayed in bed) was unknown.  No follow-up attempts are possible. No further information was expected.