COVID-19; This literature-non-study case was reported in a literature article and describes the occurrence of COVID-19 (COVID-19) in an 81-year-old male patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 prophylaxis.   Concurrent medical conditions included Hypertension, Chronic kidney disease, Diabetes mellitus and Cancer.  On an unknown date, the patient received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On an unknown date, the patient experienced COVID-19 (COVID-19) (seriousness criteria death and hospitalization). The reported cause of death was covid-19. It is unknown if an autopsy was performed.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On an unknown date, Body mass index: 28.5.   For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown), the reporter did not provide any causality assessments.   No concomitant and treatment medications were reported.  Patient was not severely immunocompromised. Months after vaccination prior to hospitalization was 5 months. Patient did not receive booster dose.  The primary aim was to describe the characteristics of fully vaccinated persons admitted with COVID-19. A retrospective review of all patients admitted with COVID-19 was conducted between 15 July and 31 August 2021. Patients were considered fully vaccinated if symptom onset or positive SARS-CoV-2 testing was at least 14 days after their final dose. Patients were identified using the electronic heath record by extracting all patients with a positive SARS-CoV-2 test during the study time period, or if they had an active COVID-19 designation by the Regulatory Authority for patients diagnosed outside the health system. Patients were included if they had COVID-19 during their hospitalization.   Of the 19 patients with in-hospital death due to COVID-19, 5 were severely immunosuppressed. Of the other 14 patients, 11 were =65 years of age and all had numerous comorbidities. Most (89.2percent) fully vaccinated patients hospitalized with symptomatic COVID-19 were greater than or equal to years old and/or severely immunosuppressed.  Against hospitalization, need for ICU care, mechanical ventilation, and in-hospital mortality for the entire cohort was estimated to be 84.5 percent, 85.1percent, 86.6 percent, and 83.1 percent, respectively. Vaccination was found to be greater than 91 percent protective against hospitalization for all age groups under 70.  128 fully vaccinated patients hospitalized with COVID-19 prior to booster vaccines were reviewed and found that 27 percent were asymptomatic, 52 percent required ICU care, and 15 percent died due to COVID-19. Most (89.2 percent) fully vaccinated patients with symptomatic COVID-19 were =65 years old and/or severely immunosuppressed.  Company comment: This literature-non-study case concerns a 81-year-old, male patient with medical history of hypertension, chronic kidney disease, diabetes mellitus and cancer without chemotherapy in the past year, who experienced the unexpected serious fatal (death and hospitalization) event COVID 19. The event occurred approximately 5 months after the second dose of mRNA-1273. No information about first dose administration date was provided. As reported the patient died due to COVID 19 during admission. Patient's multiple comorbidities and advanced age are confounding factors for fatal outcome. The benefit-risk relationship of mRNA-1273 is not affected by this report.   This case was linked to US-MODERNATX, INC.-MOD-2022-676744 (E2B Linked Report).; Sender's Comments: This literature-non-study case concerns a 81-year-old, male patient with medical history of hypertension, chronic kidney disease, diabetes mellitus and cancer without chemotherapy in the past year, who experienced the unexpected serious fatal (death and hospitalization) event COVID 19. The event occurred approximately 5 months after the second dose of mRNA-1273. No information about first dose administration date was provided. As reported the patient died due to COVID 19 during admission. Patient's multiple comorbidities and advanced age are confounding factors for fatal outcome. The benefit-risk relationship of mRNA-1273 is not affected by this report. US-MODERNATX, INC.-MOD-2022-676744:70 yo patient; Reported Cause(s) of Death: COVID-19