after the Covid shot, her cancer came back out of remission,her doctor said "it came back with a vengeance; she has nerve damage in her leg; she has a tingly feeling when she touches her bottom teeth.; her entire chin area and bottom teeth became numb/it is just numb; Nerve pain; her lower lip, straight down on both sides , and her entire chin area and bottom teeth became numb/ it has not gotten worse or better/ it is just numb/When she brushes her teeth she has to be careful because she doesn't have feeling/She can't say; This spontaneous case was reported by a consumer and describes the occurrence of PLASMA CELL MYELOMA (after the Covid shot, her cancer came back out of remission,her doctor said "it came back with a vengeance) in a 58-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 038B21A and 407B21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     The patient's past medical history included Multiple myeloma in remission since December 2020 and Stem cell transplant in October 2020. Concurrent medical conditions included Multiple myeloma since 2020, Asthma, Acid reflux (esophageal) and Nerve pain. Concomitant products included LANSOPRAZOLE for Acid reflux (esophageal), MONTELUKAST SODIUM for Asthma, GABAPENTIN for Nerve pain, VITAMIN D NOS, VITAMIN B COMPLEX, CALCIUM, MAGNESIUM, SULFAMETHOXAZOLE, Acyclovir and MULTIVITAMIN [VITAMINS NOS] for an unknown indication.   On 12-Apr-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 10-May-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 11-May-2021, the patient experienced HYPOAESTHESIA ORAL (her lower lip, straight down on both sides , and her entire chin area and bottom teeth became numb/ it has not gotten worse or better/ it is just numb/When she brushes her teeth she has to be careful because she doesn't have feeling/She can't say he.). On 20-May-2021, the patient experienced PLASMA CELL MYELOMA (after the Covid shot, her cancer came back out of remission,her doctor said "it came back with a vengeance) (seriousness criteria hospitalization and medically significant). On an unknown date, the patient experienced NERVE INJURY (she has nerve damage in her leg), DENTAL PARAESTHESIA (she has a tingly feeling when she touches her bottom teeth.), HYPOAESTHESIA (her entire chin area and bottom teeth became numb/it is just numb) and NEURALGIA (Nerve pain). At the time of the report, PLASMA CELL MYELOMA (after the Covid shot, her cancer came back out of remission,her doctor said "it came back with a vengeance), NERVE INJURY (she has nerve damage in her leg), HYPOAESTHESIA ORAL (her lower lip, straight down on both sides , and her entire chin area and bottom teeth became numb/ it has not gotten worse or better/ it is just numb/When she brushes her teeth she has to be careful because she doesn't have feeling/She can't say he.), DENTAL PARAESTHESIA (she has a tingly feeling when she touches her bottom teeth.), HYPOAESTHESIA (her entire chin area and bottom teeth became numb/it is just numb) and NEURALGIA (Nerve pain) outcome was unknown.      For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown), the reporter did not provide any causality assessments.   She was diagnosed in 2020 with Multiple Mieloma. She states that in December2020 her cancer went into remission, and she was taking Revlimid as a maintenant. In May2021, after the Covid shot, her cancer came back out of remission, and her doctor said "it came back with a vengeance", it got worse, it was around 20May2021. She spent the entire month of June in the hospital (she was admitted to the hospital), was admitted for 28 days, and she had chemo in the hospital, and since then she has had weekly chemo treatment that stopped 2 weeks ago, because the chemo was having an effect on her numbers. She states she is on a resting period now, and in October they will do a bone biopsy to check how much cancer is still there, and a new treatment will be in October.  It was reported that the patient can't say it was 100% not because of the vaccine, but feels it was weird that it happened the day after the second dose.  Company Comment: This case concerns a 58 year-old female patient with history of multiple myeloma  in remission and stem cell transplant, who experienced the unexpected serious event of Multiple myeloma. The event occurred approximately 10 days after the second dose of mRNA-1273 vaccine. The natural history of malignancy, including remission and reoccurrence, remains a confounder. The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report.; Sender's Comments: This case concerns a 58 year-old female patient with history of multiple myeloma  in remission and stem cell transplant, who experienced the unexpected serious event of Multiple myeloma. The event occurred approximately 10 days after the second dose of mRNA-1273 vaccine. The natural history of malignancy, including remission and reoccurrence, remains a confounder. The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report.