had a hard time sleeping but then woke up "with robust fever that lasted all weekend 99-100.5 that persisted all Saturday and Sunday; had a hard time sleeping but then woke up "with robust fever that lasted all weekend 99-100.5 that persisted all Saturday and Sunday; she felt jittery and light headed; her face was flushed; as the day went on her face had increased redness; her heartrate increased lasting for quite some time; she felt jittery; mouth blew up like a fish, her lips got completely swollen up until yesterday,her lips were almost up to her nose; did have a hard time breathing; lips got completely swollen up; This is a spontaneous report from a contactable consumer. This 59-year-old female patient received first dose of bnt162b2 (PFIZER-BIONTECH COVID-19 VACCINE, Solution for injection, Lot number: EN6203, Expiry date Jun2021) via unspecified route of administration, administered in left arm on 05Mar2021 at 14:10 (at age of 59-years-old) as dose 1, single for COVID-19 Immunisation. Patient medical history include Ulcerative colitis , autoimmune disorder,  COVID-19 from 18Nov2020 (Caller also reports that my mom (88-year-old) and I had covid around 18Nov2020, we were diagnosed on 24Nov2020) , Caller report reports that they did not need to go to the hospital and they were not intubated had persistent fevers for weeks and runny noses, and cough and headache and body aches, and nausea, until Jan2021, so they were sick for a long time. Patient concomitant medications were not reported. Patient previously took Vancomycin had a severe allergic reaction to Vancomycin about 7 years ago. Patient did not receive any other medications within 4weeks prior to vaccination. Caller reports that on 5Mar2021 around 14:10 she received the first dose of the Pfizer covid vaccine and she reports that due to having extreme allergic reaction to Vancomycin, she was asked to wait for 30 minutes to monitor for a reaction rather than the standard 15 minutes. She reports that she waited 30 minutes then went to her car. When she went to take off her mask when she noticed that her face was flushed, but otherwise she felt ok. She reports that she drove home and as the day went on her face had increased redness, her heartrate increased lasting for quite some time, and she felt jittery and lightheaded. She reports that she went to bed, had a hard time sleeping but then woke up "with robust fever that lasted all weekend 99-100.5 that is what her temperature was after it was suppressed with Tylenol, so it would have been more if she was not taking Tylenol, and that fever lasted all day,reported the caller had no fever. She went on to report that her lip blew up "it looked like a fish mouth, like Botox gone wrong", the entire top lip completely swollen, starting on the right side, and filling in over to the left. Caller reports "but my throat didn't close". Caller states that she did have a hard time breathing, but her throat didn't close. Caller states that she would say that the only difference between what she experienced after her COVID vaccine, and true anaphylactic shock, was that she did not have her throat close up. Caller enquired if there is any information on mixing the vaccines? Caller asks can someone get the second dose from a different manufacturer if they had a reaction to the first?  Caller wants to gather some information to see if she should get the second dose. Patient received treatment for the fever with Tylenol. Patient did not visit to any emergency room. Patient was not hospitalized. The Patient underwent lab test and procedures include body temperature was 99-100.5 in Mar2021; Sars cov-2 test was positive on 24Nov2020.The Outcome of the event pyrexia was recovered in 2021 and all other events was unknown.  No follow-up attempts are possible. No further information is expected.