systemic inflammation; circulatory overload/she had a problem with her circulatory system; kidney failure, disease in her lungs and heart; couldn't lift her arm or her hand; her body was swollen; kidney failure, disease in her lungs and heart; kidney failure, disease in her lungs and heart; This spontaneous report was received from a consumer (patient's daughter) and refers to a 91-year-old female. The patient's concurrent conditions included lymphedema in legs, hypertension and penicillin allergy (vomiting, dizzy and couldn't walk). Concomitant medications included losartan, "B12" and influenza vaccine. The patient was being treated with "Microban" for the urinary tract infection (UTI) and had a bad reaction from it, so she was admitted to the hospital for intravenous (IV) treatment of her UTI.   On an unknown date in February 2022 (reported as sometime between 02-FEB-2022 and 14-FEB-2022 (could not specify exact date)), while she was in the hospital the patient was vaccinated with pneumococcal vaccine, polyvalent (23-valent) (PNEUMOVAX23) (strength, dose, lot #, expiration date, and route of administration were not provided) for pneumonia prophylaxis.  The reporter stated the pneumococcal vaccine, polyvalent (23-valent) (PNEUMOVAX23) produced a systemic inflammation in the patient's body (systemic inflammatory response syndrome) that lent to her demise. The patient already had problems with inflammation because she had a problem with her circulatory system (cardiovascular disorder) because she had lymphedema. The reporter stated the inflammation got so bad after the pneumococcal vaccine, polyvalent (23-valent) (PNEUMOVAX23) that the patient couldn't lift her arm or her hand (movement disorder), her body was swollen (swelling) to the extent of her having kidney failure (renal failure), disease in her lungs (lung disorder) and heart (cardiac disorder). Everything became inflamed. Unspecified bloodwork and urine sample were performed, while the results were not reported. The patient was reportedly treated with azithromycin, heparin and other unspecified medications. The patient passed away on 22-FEB-2022. The cause of death was reported as systemic inflammation (systemic inflammatory response syndrome) and circulatory overload (cardiovascular disorder). It was unknown whether an autopsy was performed. The outcome of other events was unknown.   The reporter stated the pneumococcal vaccine, polyvalent (23-valent) (PNEUMOVAX23) was administered without consent (she stated she was the patient's medical legal representative) and she had only given permission for medications to be administered that would treat the patient's UTI. The reporter further stated the patient had never received a pneumonia vaccination at any time because the patient was allergic to it so now once this had entered into her body the inflammation of it and the systemic inflammation that it produced lent to her demise. The reporter also stated the patient had been on other unspecified Merck medications over the years for "treatment of other things, specifically blood pressure medications and maybe some other stuff" not clarified further. The reporter stated that Merck should take liability of this event and asked what was Merck's part in the liability of the patient's death? She asked "are you having someone from your organization assist the victim? How are you assisting in getting the necessary attention that this vaccination may not be good for someone that is 91 years old because of the inflammatory properties? Why are you not doing anything to assist in getting through to the vaccine injury program? I am asking you to help me get the vaccine injury compensation for my mother. I want my mom to be compensated for what happened to her. I'm not asking for a lot, I'm not trying to be rich from his situation but my mom passed away. I don't want to have to go to court to bring out all the facts that we all know that none of this stuff do what it suppose to do, I really would like to talk about how we can solve this amicably."  The causal relationship between the events of systemic inflammatory response syndrome and cardiovascular disorder and pneumococcal vaccine, polyvalent (23-valent) (PNEUMOVAX23) was considered as related, the reporter stated the patient passed away due to receiving pneumococcal vaccine, polyvalent (23-valent) (PNEUMOVAX23). The causal relationship between other events and pneumococcal vaccine, polyvalent (23-valent) (PNEUMOVAX23) was not reported.   Upon internal review, renal failure and systemic inflammatory response syndrome were determined to be medically significant.; Reported Cause(s) of Death: systemic inflammation; circulatory overload