Shortness of breath; fall short of breath; Tightness in her chest; Severe allergic reaction; This is a spontaneous report from a contactable consumer (patient). A 54-year female patient received the second dose of BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE; Lot Number: EN6202, Expiration Date: Jun2021), via an unspecified route of administration in left arm, on 26Feb2021 at 08:30, at a single dose, for COVID-19 immunization. The patient's medical history and concomitant medications were not reported. The patient previously took the first dose of BNT162B2 (Lot Number: EL9262, Expiration Date: May2021) in Feb2021 at 54 years of age (left arm) for COVID-19 immunization and experienced fever, soreness at the shot site, and body aches. The patient worked for a hospital but not in a clinical setting; she is an administrator. The patient went for her annual physical last week (Mar2021) and her doctor had called to tell her that she had no antibodies (negative COVID-19 antibody test). The patient had gotten both shots in Feb2021 and was concerned about that. The patient wanted to know if this is something that is common and why does she not have antibodies when she already took the vaccine; what is going on and why was this happening. The patient understands that the vaccine was taken to create antibodies within 14 days of receiving it. The patient was obviously concerned that she is not immune. The patient wanted to protect herself as there was a surge where she lives. The patient lives with 2 sick people and works in the hospital. The patient did have a reaction and was mainly concerned about the shortness of breath on 01Mar2021. 3 days after the second shot, she had gone to take her normal errand walk and started to fall short of breath and tightness in her chest on 01Mar2021. It was not severe. Also, the patient experienced a severe allergic reaction 3 days after the second shot (01Mar2021) but did not have to go to the emergency room. The patient noticed that when she started talking, like if she spoke, she felt a little shortness of breath; states that this is not common. No treatment was given for the events. The patient took it easy for the following week, knowing that she took the vaccine. The patient kind of thought it was working its way into her system. The patient not an athlete and is still concerned about the shortness of breath. It is not constant. This is something that she notices and did not have prior to this vaccine. Never had this feeling, like when bike riding and taking walks, states that she feels it in her chest. It is nothing severe, assuming the vaccine didn't screw anything up in her system. When the patient went for her annual last week (Mar2021), she mentioned this to her doctor. It not continuous but every now and then, feels a bit of this reaction when having to speak for a long time. The patient felt like she is running out of breath. The doctor specializes in cardiology so checked everything, including a chest X-ray and electrocardiogram (EKG) and everything was normal or fine in Mar2021. The symptoms had lasted a couple of days. The patient's main concern was that she has no antibodies. The patient gave blood before her annual exam (unspecified date) and they automatically checked for antibodies and did not find any. The patient was told in an email that it was their standard for when donating blood, to test for COVID-19 antibodies. The patient was also tested as part of her annual exam. This is an emergency vaccine; states that you never know what will come up and wanted to know that she can be safe around other people. The patient lives with her elderly mother and has a brother whom she is responsible for. The patient was now concerned that she is still very much in a situation where she could get sick and that it could be severe. The patient would like to know why this vaccine did not generate antibodies and if there is a booster. It is concerning that she has no antibodies. The patient recovered from the events in Mar2021.