MIGRAINES; COULD NOT WALK; JAW LOCKED OPEN; FOOD POISONING; LIVER DAMAGE; DEHYDRATED; HIPS AND KNEES STARTED LOCKING UP/ LOCKED UP MUSCLES; CHILLS; EXPLOSIVE DIARRHEA; FEVER; HEADACHE; SCIATIC/MUSCLE PAIN; BLURRED VISION LIKE LENS WITH RAIN DROPS ON IT/COULD NOT SEE; SLUGGISH/SLOW; OUT OF BREATH WHILE RUNNING/WORKING OUT; This spontaneous report received from a patient concerned a 32 year old female. The patient's weight was 127 pounds, and height was 70 inches. The patient's concurrent conditions included: latex skin sensitivity. The patient received covid-19 vaccine ad26.cov2.s (suspension for injection, route of admin not reported, batch number: 1855194 expiry: 09-APR-2022) dose was not reported, 1 total, administered on left deltoid on 03-NOV-2021 for prophylactic vaccination. No concomitant medications were reported.   On 03-NOV-2021, at evening the patient began to experience what she referred to as the regular side effects of fever, headache and chills, and then her hips and knees started locking-up by 7-9 pm, felt like sciatic/muscle pain, that cleared up. Patient went to urgent care to make sure all was ok. The patient experienced diarrhea the same evening on 03-Nov-2021 and it was bright yellow/explosive like food poisoning for 7 days, the patient felt miserable, dehydrated/urine dark.  On 17-Nov-2021, two weeks after vaccination, the patient felt this was normal but had migraines with occasional diarrhea for 10 days after vaccination and reported that she could not walk until 1 pm the next day from those muscle cramps. The patient stated that jaw was feeling like it locked open as well. Patient added that, on an unspecified day in Nov-2021 she went back to urgent care because her vision was blurred like lens with rain drops on it, felt it was a temporary side effect and possibly just needed a smaller vaccine dose/dose adjustment. Patient had blood work on 17-Nov-2021 which showed liver damage and ALT/AST levels were high (elevated liver enzymes), where prior they were in normal range. HCP was able to palpate liver. Patient had bloodwork both in January and also 1 week prior to vaccination as she wanted to check prior to getting vaccinated if she was healthy and tested for covid-19 prior to vaccine. Patient stated that she had been to urgent care several times.  On an unspecified date the patient experienced, blurred vision like lens with rain drops on it/could not see, sluggish/slow and could not walk and out of breath while running/working out. The action taken with covid-19 vaccine ad26.cov2.s was not applicable. The patient recovered from dehydrated, hips and knees started locking up/ locked up muscles, jaw locked open, chills, explosive diarrhea, fever, and sciatic/muscle pain, had not recovered from liver damage, migraines, and headache, and the outcome of blurred vision like lens with rain drops on it/could not see, sluggish/slow, food poisoning, could not walk and out of breath while running/working out was not reported. This report was serious (Other Medically Important Condition).; Sender's Comments: V0: 20211154558-COVID-19 VACCINE AD26.COV2.S-Liver damage. This event(s) is considered unassessable. The event(s) has a compatible/suggestive temporal relationship, is unlabeled, and has unknown scientific plausibility. There is no information on any other factors potentially associated with the event(s).