hives sometimes wakes him up at night; Chronic Idiopathic Spontaneous Urticaria/ hives/ hives getting worse/ ongoing hives/ hives have persisted/ hives affected different parts of his body, back, rear end, head, face, and underarms/ hives ugly and debilitating.; This spontaneous case was reported by a consumer and describes the occurrence of CHRONIC SPONTANEOUS URTICARIA (Chronic Idiopathic Spontaneous Urticaria/ hives/ hives getting worse/ ongoing hives/ hives have persisted/ hives affected different parts of his body, back, rear end, head, face, and underarms/ hives ugly and debilitating.) and SLEEP DISORDER (hives sometimes wakes him up at night) in a 57-year-old male patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 065F21A, 037K20A and 042L20A) for COVID-19 vaccination.     Other vaccines given within 1 month prior to Moderna COVID-19 vaccine (type, brand, lot, route, dose ) were none. The patient never had COVID + test or diagnosis.  Concurrent medical conditions included Immunodeficiency NOS (Unknown medications- To treat Immune Deficiency) and Drug allergy.   On 15-Jan-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) .5 milliliter. On 17-Feb-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to .5 milliliter. On 09-Nov-2021, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to .25 milliliter. In December 2021, the patient experienced CHRONIC SPONTANEOUS URTICARIA (Chronic Idiopathic Spontaneous Urticaria/ hives/ hives getting worse/ ongoing hives/ hives have persisted/ hives affected different parts of his body, back, rear end, head, face, and underarms/ hives ugly and debilitating.). On an unknown date, the patient experienced SLEEP DISORDER (hives sometimes wakes him up at night). At the time of the report, CHRONIC SPONTANEOUS URTICARIA (Chronic Idiopathic Spontaneous Urticaria/ hives/ hives getting worse/ ongoing hives/ hives have persisted/ hives affected different parts of his body, back, rear end, head, face, and underarms/ hives ugly and debilitating.) had not resolved and SLEEP DISORDER (hives sometimes wakes him up at night) outcome was unknown.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On an unknown date, Allergy test: nothing nothing.         Concomitant medications included unknown medications to treat immune deficiency. The patient reported receiving the first Moderna booster dose on 09-Nov-2021. The patient stated prior to Christmas 2021 he started to develop hives for no reason. The patient mentioned that he never had a problem with hives (urticaria) before in the past. He reported the hives were getting worse and had persisted and affected different parts of his body at different times including his stomach, back, rear end, head, face, and underarms. The patient stated the hives might appeared for one hour and then resolved throughout the day. He reported that the hives sometimes waked him up at night. The patient mentioned he had seen three separate physicians including an Allergist, Infectious Disease Specialist, and a Dermatologist. The patient reported all physicians were stumped on why he was experiencing ongoing hives. He stated the full battery of allergy test were performed and results came up with nothing. He stated he was currently not being treated with any over the counter or prescription medications. He stated he was diagnosed as having Chronic Idiopathic Spontaneous Urticaria by the physicians. He mentioned the hives were ugly and debilitating and he was currently out of work because of the hives. The patient also mentioned he joined an online support group. The patient reported he had not received the second Moderna booster dose.