"one shingle" above / right eye / the eye started acting up again; eye to be bulged sore; Eye pain; This case was reported by a consumer via call center representative and described the occurrence of ophthalmic herpes zoster in a 74-year-old female patient who received Herpes zoster (Shingrix) for prophylaxis.   Co-suspect products included COVID-19 VACCINE for prophylaxis and COVID-19 VACCINE for prophylaxis.   The patient's past medical history included gastrointestinal injury, shingles (Family History) (to mother), alzheimer's disease (Family History) (to sister), shingles (1st outbreak when she was in high school, another outbreak 2 years after receiving shingles vaccine), gastrointestinal infection (infection a few years back- lost some of the lining of her colon. colon was now delicate), influenza (the 1970's when the patient had the flu), ophthalmic herpes zoster (On an unknown date in 2020, one shingle above her right eye causing it to be sore and bulged)), bulging eyes and sore eye. Previously administered products included Zostavax with an associated reaction of herpes zoster (about 2 years after the shot she developed of shingles) and COMPAZINE with an associated reaction of feeling abnormal (body was wacky with the way it sometimes responds to medications). Concurrent medical conditions included arthritis (left arm), bursitis (left arm), thyroid disorder (unspecified), blood pressure high and constipation. Concomitant products included macrogol (Miralax).   On 11th March 2021, the patient received the 1st dose of Shingrix (intramuscular). On 20th May 2021, the patient received the 1st dose of COVID-19 VACCINE. On 31st May 2021, the patient received the 2nd dose of COVID-19 VACCINE. On an unknown date, between 2 and 4 months after receiving Shingrix, the patient experienced ophthalmic herpes zoster (serious criteria GSK medically significant), bulging eyes (serious criteria GSK medically significant) and eye pain. On an unknown date, the outcome of the ophthalmic herpes zoster, bulging eyes and eye pain were unknown.   It was unknown if the reporter considered the ophthalmic herpes zoster, bulging eyes and eye pain to be related to Shingrix.  Additional details were provided as follows: The case was reported by patient herself. The patient was taking Miralax (with apple juice) for the prevention of constipation taken everyday. The patient said everything was coming out so she had to decrease her Miralax to every other day instead of every day The patient stated that one time in the 1970's when she had the flu she received a shot of COMPAZINE and it didn't work for her. She had a backwards reaction to the Compazine because her body was wacky. The patient had her first shingles outbreak when she was in high school. The patient received the (live) shingles shot (Zostavax) but about 2 years after the shot she developed of shingles on her back from her shoulder to her waist. The reporter asked if the patient reported this (vaccine failure) to the manufacture (Merck) she said no but that she did reported it to her doctor who indicated he would report it.  The patient had 1st Shingrix shot in right deltoid. The patient did not have the lot number or expiration date for the Shingrix shots but did provide the phone number for the pharmacy where they were administered.  In 2020, the patient got one shingle above her right eye causing her eye to be bulged and sore. The patient had provided her eye doctor's contact information because the eye doctor had information regarding prescription medication she received to treat the condition. The patient said, after the second Covid shot the eye started acting up again. The reporter consented to follow up. For tolerance to the 2nd dose of shingrix refer case US2021159315.; Sender's Comments:  US-GLAXOSMITHKLINE-US2021159315:Same reporter