facial hemiplegia; This waxed and weighed in twitching of my eye and drooping of my mouth that was intermittent it was not anything to do with bell's palsy; This is a spontaneous report received from contactable reporter(s) (Other HCP). The reporter is the patient. A 56 year-old female patient received bnt162b2 (BNT162B2) (Batch/Lot number: unknown) at the age of 56 years as dose 1, single for covid-19 immunisation. The patient's relevant medical history was not reported. Concomitant medication(s) included: levothyroxine sodium (SYNTHROID); imipramine. The patient did not receive any other vaccine within 4 weeks prior to the vaccine. Prior to the vaccination, the patient was not diagnosed with COVID-19. It was also reported that since the vaccination, the patient had not been tested for COVID-19.  The following information was reported: FACIAL PARALYSIS (hospitalization, disability, medically significant) with onset 04Mar2022, outcome "not recovered", described as "facial hemiplegia"; MUSCLE TWITCHING (hospitalization, disability) with onset 04Mar2022, outcome "not recovered", described as "This waxed and weighed in twitching of my eye and drooping of my mouth that was intermittent it was not anything to do with bell's palsy".  The patient was hospitalized for facial paralysis, muscle twitching (hospitalization duration: 3 day(s)). The events "facial hemiplegia" and "this waxed and weighed in twitching of my eye and drooping of my mouth that was intermittent it was not anything to do with bell's palsy" were evaluated at the physician office visit and emergency room visit. Therapeutic measures were taken as a result of facial paralysis, muscle twitching.  Clinical course: 2 days after receiving the Pfizer the patient developed facial hemiplegia. This waxed and weighed in twitching of my eye and drooping of my mouth that was intermittent it was not anything to do with bell's palsy. Since that time the patient continues to have heaviness in my eye nose and mouth and most recently have started twitching and having a lot of facial hemiplegia. Ihe patient never had this happen to her ever before in her life. She was a critical care nurse and she was volunteer giving gifts "I got one myself and 2 days later that's what happened I actually ended up in the hospital as a cold stroke but it was no cold stroke.  I know I'm on medication and am headed in to soon get "O talks injected" into my muscles to stop my face."  The lot number for bnt162b2 was not provided and will be requested during follow up.; Sender's Comments: Based on the information currently available, a possible contribution of the suspect product administration to the reported serious events cannot be completely excluded, due to a temporal relationship. This case will be reassessed when additional information becomes available. The impact of this report on the benefit/risk profile of the Pfizer drug is evaluated as part of Pfizer procedures for safety evaluation, including the review and analysis of aggregate data for adverse events. Any safety concern identified as part of this review, as well as any appropriate action in response, will be promptly notified to Regulatory Authorities, Ethics Committees and Investigators, as appropriate.