Within 12 hours after the first dose: Upon retiring to bed, I experienced the sudden onset of very unpleasant ice cold feet and knees, which could not be remedied with blankets. This lasted all night; Within 12 hours after the first dose: Upon retiring to bed, I experienced the sudden onset of very unpleasant ice cold feet and knees, which could not be remedied with blankets. This lasted all night; Within 12 hours after the first dose: Upon retiring to bed, I experienced the sudden onset of very unpleasant ice cold feet and knees, which could not be remedied with blankets. This lasted all night; This is a spontaneous report from a contactable physician.   A 69-years-old male patient received first dose of bnt162b2 (PFIZER-BIONTECH COVID-19 VACCINE, Solution for injection, Lot number: unknown), via an unspecified route of administration, administered in Arm Left on 22Apr2021 12:45 (at the age of 69 years old) as DOSE 1, SINGLE for covid-19 immunisation. Medical history included ADHD (attention deficit hyperactivity disorder) from an unknown date and unknown if ongoing , autism spectrum disorder from an unknown date and unknown if ongoing , food allergy from an unknown date and unknown if ongoing Known allergies: Cashews. Concomitant medication(s) included Ritalin (Methylphenidate Hydrochloride) taken for an unspecified indication, start and stop date were not reported; Elavil (Allopurinol) taken for an unspecified indication, start and stop date were not reported; Aspirin (E.C.) ( Acetylsalicylic Acid) taken for an unspecified indication, start and stop date were not reported. It was reported that If other vaccine in four weeks was No. If COVID prior vaccination was No. If COVID tested post vaccination was No. The patient experienced within 12 hours after the first dose: upon retiring to bed, i experienced the sudden onset of very unpleasant ice cold feet and knees, which could not be remedied with blankets. this lasted all night on 22Apr2021 23:45 and reoccurred only at bedtime for days.The same pattern appearred again about 6 weeks later, along with pulse and blood pressure irregularities. Ae resulted in Doctor or other healthcare professional office/clinic visit, Disability or permanent damage, Congenital anomaly or birth defect. About 2 months after the last vaccine dose, a first-occurrence thyroglossal duct cyst (a 'birth defect' which appears in early life, almost never in the elderly) arose on the left side between the hyoid bone and the thyroid cartilage.Therapeutic measure were as no as a result of all event. The outcome of events was not recovered.  No follow-up attempts are possible. No further information is expected.; Sender's Comments: Based on the  information in the case report, a possible causal relationship between the events Peripheral coldness, Heart rate irregular , Blood pressure abnormal and suspect drug BNT162B2 cannot be excluded" The impact of this report on the benefit/risk profile of the Pfizer product is evaluated as part of Pfizer procedures for safety evaluation, including the review and analysis of aggregate data for adverse events. Any safety concern identified as part of this review, as well as any appropriate action in response, will be promptly notified to regulatory authorities, Ethics Committees, and Investigators, as appropriate.