the numbness and tingling was very intense/ It was to the point of her heart and she had a panic attack; she started having issues with her right knee like it was pulling or locking as well as numbness/ right knee: it was like a pull and like a lock; she started having issues with her right knee like it was pulling or locking as well as numbness; difficulty in walking/ walking slowly, can walk but very slowly/ couldn't walk no more/ walks like a robot, very slow; she started having issues with her right knee like it was pulling or locking as well as numbness; her shoulder and neck are very stiff and cracks all the time/ stiffness in both legs, shoulders, and neck; her shoulder and neck are very stiff and cracks all the time; joint pain; depression/ depressed; tingling and numbness on right side of body; joints are still stiff; neck hurts; very frustrated; It was to the point of her heart and she had a panic attack; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP) from medical information team. The reporter is the patient.  A 49 year-old female patient received bnt162b2 (BNT162B2), administered in arm left, administration date 07May2021 (Batch/Lot number: it is either FW0182 or EW0182, Expiration Date: Aug2021) at the age of 49 years as dose 2, single for covid-19 immunisation. Relevant medical history included: "chondromalacia" (unspecified if ongoing), notes: Her knee has chondromalacia which is a type of arthritis of athletes because she is runner. There were no concomitant medications. Vaccination history included: Bnt162b2 (Dose: 1, lot: EW0161, Expiry: Jul2021, NDC: unknown. Dose: unknown. It was given in left arm), administration date: 16Apr2021, when the patient was 49 years old, for Covid-19 Immunization. The following information was reported: CARDIAC DISORDER (medically significant) with onset 2021, outcome "unknown", described as "the numbness and tingling was very intense/ It was to the point of her heart and she had a panic attack"; JOINT LOCK (non-serious) with onset 2021, outcome "unknown", described as "she started having issues with her right knee like it was pulling or locking as well as numbness/ right knee: it was like a pull and like a lock"; HYPOAESTHESIA (non-serious) with onset 2021, outcome "recovered", GAIT DISTURBANCE (non-serious) with onset 2021, outcome "recovering" and all described as "difficulty in walking/ walking slowly, can walk but very slowly/ couldn't walk no more/ walks like a robot, very slow"; MUSCLE STRAIN (non-serious) with onset 2021, outcome "unknown", described as "she started having issues with her right knee like it was pulling or locking as well as numbness"; MUSCULOSKELETAL STIFFNESS (non-serious) with onset 2021, outcome "unknown", described as "her shoulder and neck are very stiff and cracks all the time/ stiffness in both legs, shoulders, and neck"; CREPITATIONS (non-serious) with onset 2021, outcome "unknown", described as "her shoulder and neck are very stiff and cracks all the time"; ARTHRALGIA (non-serious) with onset 2021, outcome "unknown", described as "joint pain"; DEPRESSION (non-serious) with onset 2021, outcome "unknown", described as "depression/ depressed"; PARAESTHESIA (non-serious) with onset 2021, outcome "recovered", described as "tingling and numbness on right side of body"; JOINT STIFFNESS (non-serious) with onset 2021, outcome "not recovered", described as "joints are still stiff"; NECK INJURY (non-serious) with onset 2021, outcome "unknown", described as "neck hurts"; FRUSTRATION TOLERANCE DECREASED (non-serious) with onset 2021, outcome "unknown", described as "very frustrated"; PANIC ATTACK (non-serious) with onset 2021, outcome "unknown", described as "It was to the point of her heart and she had a panic attack". The events "the numbness and tingling was very intense/ it was to the point of her heart and she had a panic attack", "she started having issues with her right knee like it was pulling or locking as well as numbness/ right knee: it was like a pull and like a lock", "she started having issues with her right knee like it was pulling or locking as well as numbness", "difficulty in walking/ walking slowly, can walk but very slowly/ couldn't walk no more/ walks like a robot, very slow", "she started having issues with her right knee like it was pulling or locking as well as numbness", "her shoulder and neck are very stiff and cracks all the time/ stiffness in both legs, shoulders, and neck", "her shoulder and neck are very stiff and cracks all the time", "joint pain", "depression/ depressed", "tingling and numbness on right side of body", "joints are still stiff", "neck hurts", "very frustrated" and "it was to the point of her heart and she had a panic attack" were evaluated at the physician office visit and emergency room visit. Clinical course as follows: patient was calling about the Pfizer Covid19 vaccine. She stated that she received her two dose and got her second dose last 07May2021. Six weeks after that, she started having issues with her right knee like it was pulling or locking as well as numbness. She is currently undergoing physical therapy and has difficulty in walking. She described it as, "I'm walking slowly, I can walk but very slowly. I walked like a rabbit." She also stated that her shoulder and neck are very stiff and cracks all the time. She said that her doctor did not give any clear diagnosis as to what was causing her joint pain but she was sure it was the vaccine who caused it. She said she has "done everything" such MRI to her brain, spine, and lower back; nerve testing for her knee as well as allergic testing. She was also prescribed with "Cymbalta" for her numbness as well as depression which she said helped with the numbness. She also said that her doctor told her that the CDC said that there are reports of the vaccine affecting the joins of people who received it. She wanted to know if there are similar reports like hers and are there recommendations to improve her condition. Calling about Pfizer COVID vaccine. Caller states she will provide her long story short. She had her first and second shot of the vaccine. The second dose was 06May2021 or 07May2021. Six weeks later, she started feeling something in her right knee It was like a pull and like a lock. She is a runner. She used to run 4 miles every day for 4 years. The orthopedist sent her to physical therapy. Caller did exercises and couldn't walk no more. After that, she had some other feeling like tingling and numbness on right side of body. Also her joints, right and left knee, started to lock down as well. She was using walker for 3 months and doing physical therapy. She had all test you could imagine ordered by neurology, orthopedist, and allergist. She has seen all kinds of doctors. She had 5 MRI's, CT scans, and everything was ok. She does not have MS or any other illness. She was on Cymbalta the last two months. Cymbalta was able to address tingling and numbness and it is almost gone right now. Her knee has been under the care of 5 orthopedists. They all say there is no reason to be on a walker. Her knee has chondromalacia which is a type of arthritis of athletes because she is runner. There is no cause to see for why she can't walk. She has been improving a little. It is 7 months since second dose of vaccine. Her joints are still stiff. She has stiffness in both legs, shoulders, and neck. They crack all the time. This is not normal. Every time she walks the good leg is cracking and people can hear it. Every step she can hear cracking. Her neck hurts and cracks a lot and is very loud and happens most when sleeping. She is very frustrated and she is very concerned. She is a very healthy woman. She is 49 years old and she walks like a robot, very slow. She has to connect her brain with her legs in order to walk, but it is slow. It is has been horrible. She has been able to work from home this month but her job requires traveling and she won't be able to travel. She is very depressed and hopes it goes away. No one to help her. She is calling to report these effects of the vaccine and to see if there are any other reports of something similar. She has seen a lot of doctors. She went to her primary doctor who said that the CDC has reported that the vaccine, she didn't say Pfizer's vaccine, has effected the joints in some people. Caller thinks it is the vaccine. Caller clarified she is looking for information if joint problems has been reported with the Pfizer vaccine. she is now seeing and under the care of Rheumatologist.  Caller didn't provide email for her doctor. Attempted to clarify dates of events. Caller states right knee pulling and locking started six weeks after second dose. The second feeling she had was the tingling and numbness. Then she had stiffness in both legs. The left leg hasn't done it very hard, but it is stiff. She had been very healthy and had no other issues. Caller clarified Cymbalta as Duloxetine. Strength: 30mg. Dose: take 30mg capsule by mouth twice a day. She started it two months ago for tingling and numbness. It's in a white bottle. Batch number is either BEY78019 or BEY78O19. Expiry: Dec2022. Manufacturer: Torrent. NDC: 13668-110-30. Quantity: 30 capsules. She went to the ER three times related to everything because she couldn't walk and the numbness and tingling was very intense. It was to the point of her heart and she had a panic attack because she thought something was happening to her. One day she asked her son to call the paramedic and they came and did test and EKG and everything was normal. That was one time and three other times she was taken to the ER because of the numbness and tingling was very intense. She did not get admitted. She remained in ER and they ordered CT and bloodwork. The patient underwent the following laboratory tests and procedures: allergy test: (2021) unknown results; blood test: (2021) unknown results; computerised tomogram: (2021) unknown results; electrocardiogram: (2021) normal; investigation: (2021) unknown results; magnetic resonance imaging: (2021) unknown results. Therapeutic measures were taken as a result of cardiac disorder, joint lock, hypoaesthesia, gait disturbance, muscle strain, musculoskeletal stiffness, crepitations, arthralgia, depression, paraesthesia, joint stiffness, neck injury, frustration tolerance decreased, panic attack.  The lot number for bnt162b2 was not provided and will be requested during follow up.