SEVERE CHEST PAIN RADIATING TO LEFT ARM; HEARTBURN; NECK PAIN IN RIGHT SIDE  RADIATED TO JAW AND EAR; PURPLE TOES; FEELING WORSE; LOSS OF APPETITE; NAUSEA; CHEST PAIN; LEG PAIN; HEADACHE; ABDOMINAL PAIN; LOWER BACK PAIN; DIARRHEA; SEVERE UNEXPLAINED ANXIETY; SHAKING; LOW GRADE FEVER; ARM PAIN; COLD FINGERS / COLD TOES; LOW VITAMIN D; ELEVATED BLOOD PRESSURE; This spontaneous report received from a patient concerned a 22 year old female. The patient's weight, height, and medical history were not reported. The patient received covid-19 vaccine ad26.cov2.s (suspension for injection, route of admin not reported, batch number: 1808978, and expiry: 13-JUN-2021) dose was not reported, administered on 02-APR-2021 for prophylactic vaccination.  No concomitant medications were reported. On APR-2021, the subject experienced low vitamin d. On APR-2021, the subject experienced elevated blood pressure. On APR-2021, the subject experienced cold fingers / cold toes. Laboratory data included: Pain scale (NR: not provided) HEADACHE (6 on pain scale), RIGHT LEG PAIN ( 5 ON PAIN SCALE), CHEST PAIN (3 ON PAIN SCALE).  On 02-APR-2021, the subject experienced arm pain. On 02-APR-2021, the subject experienced low grade fever. Laboratory data included: Body temperature (NR: not provided) 99 F.  On 08-APR-2021, the subject experienced abdominal pain. On 08-APR-2021, the subject experienced lower back pain. On 08-APR-2021, the subject experienced diarrhea. On 08-APR-2021, the subject experienced severe unexplained anxiety. On 08-APR-2021, the subject experienced shaking. On 08-APR-2021, the subject experienced chest pain. On 08-APR-2021, the subject experienced leg pain. On 08-APR-2021, the subject experienced headache. On 09-APR-2021, the subject experienced loss of appetite.  On 09-APR-2021, the subject experienced feeling worse. On 09-APR-2021, the subject experienced nausea. Laboratory data included: Blood test (NR: not provided) NORMAL, and CT scan (NR: not provided) NORMAL.  On 10-APR-2021, the subject experienced neck pain in right side radiated to jaw and ear. On 10-APR-2021, the subject experienced purple toes. Laboratory data included: COVID-19 virus test negative (NR: not provided) NEGATIVE.  On 13-APR-2021, Laboratory data included: Blood test (NR: not provided) LOW VITAMIN-D.  On 14-APR-2021, Laboratory data included: COVID-19 virus test negative (NR: not provided) NEGATIVE.  On 15-APR-2021, Laboratory data included: Ultrasound Doppler (NR: not provided) normal.  On 16-APR-2021, Laboratory data included: COVID-19 virus test negative (NR: not provided) NEGATIVE.  On 17-APR-2021, the subject experienced severe chest pain radiating to left arm. On 17-APR-2021, the subject experienced heartburn. Laboratory data included: Blood test (NR: not provided) NORMAL, CT scan (NR: not provided) NORMAL, and EKG (NR: not provided) NORMAL.  Other relevant diagnostics included: Mono test on 10-apr-2021 result - negative D-dimer test for blood clot on 13-apr-2021 result - normal l.  On 19-APR-2021, treatment medications included: omeprazole.  On 26-APR-2021, Laboratory data included: Blood test (NR: not provided) NORMAL. Additional treatment medications (dates unspecified) included: paracetamol, pantoprazole, and prednisolone. The action taken with covid-19 vaccine ad26.cov2.s was not applicable. The patient recovered from diarrhea, and shaking on 15-APR-2021, loss of appetite, and nausea on 12-APR-2021, and arm pain, and low grade fever, had not recovered from headache, leg pain, severe chest pain radiating to left arm, and chest pain, and the outcome of abdominal pain, lower back pain, severe unexplained anxiety, neck pain in right side radiated to jaw and ear, purple toes, low vitamin d, elevated blood pressure, cold fingers / cold toes, feeling worse and heartburn was not reported. This report was non-serious.