red blotches on her face and her face was reddened/red blotches all over her face/the red blotches on her face looked more like hives/the red, blotchy, hive-like things on her face; red blotches on her face and her face was reddened/Redness facial; the red blotches on her face looked more like hives; This is a spontaneous report from a contactable pharmacist (husband) via Health Authority. A 65-year-old female patient received bnt162b2 (PFIZER-BIONTECH COVID-19 MRNA VACCINE), via an unspecified route of administration administered in right arm at a hospital facility on 16Feb2021 (time the vaccination was given: 16:00-16:15) (Batch/Lot number was not reported) (at the age of 65-year-old) as DOSE 1, SINGLE for covid-19 immunisation; and trastuzumab (HERCEPTIN), via an unspecified route of administration from 03Feb2021 (Batch/Lot number was not reported) and ongoing, at unspecified dose for breast cancer female. The patient had no prior vaccinations within four weeks and had no relevant test. Medical history included breast cancer from 2020 and double mastectomy. There were no concomitant medications. The patient previously took perjeta for chemotherapy and experienced itch. The patient received her first dose bnt162b2 on 16Feb2021 and has her second dose scheduled on 09Mar2021. The husband specified patient was undergoing chemotherapy for breast cancer, which was diagnosed 6 month ago; and had a Herceptin infusion on 03Feb2021. Husband explained a day post vaccination, on 17Feb2021, his wife developed "red blotches on her face and her face was reddened." It was further reported that patient was a cancer patient, clarifying his wife has breast cancer. He said his wife received 4 different chemotherapy drugs, and had a double mastectomy. He said his wife was currently taking 2 chemotherapy drugs; Herceptin and Perjeta. He clarified the Perjeta was recently discontinued because the oncologist thought the Perjeta was making his wife itch. He said his wife was only on Herceptin now. Reported a week ago his wife started radiation therapy. Reported 2 weeks ago, he and his wife went to (Hospital address), and they both received their first COVID-19 Vaccine. He said the next morning (17Feb2021), his wife had red blotches allover her face, and her face was reddened. He said the red blotches on her face looked more like hives. He clarified his wife did not have any itching, discomfort, or difficulty in breathing. He said his wife had no other symptoms, only the red, blotchy, hive-like things on her face, and the redness of her face. He said the previous week, his wife had received a Herceptin infusion on Wednesday (10Feb2021). He said his wife received her first COVID-19 Vaccine dose the following Tuesday, 16Feb2021. He said he was not sure if the Herceptin or the COVID-19 Vaccine caused his wife's reaction, though he tends to think it was the COVID-19 Vaccine. He said his wife is scheduled to receive her next Herceptin infusion on Wednesday, 24Feb2021. He said in the meantime, he has tried to call the CDC for information on the COVID-19 Vaccine and his wife's reaction. He said the CDC never called him back. He said he tried to call Pfizer previously, but it was difficult to get through, and he never ended up speaking with anyone at Pfizer. He said he called (Hospital) to see if his wife should get the second COVID-19 Vaccine shot. He said he spoke to a girl at (Hospital), and she wouldn't give him any information. He said he wanted to know if his wife's reaction is from the COVID-19 Vaccine, and if his wife should get the second COVID-19 Vaccine shot. He said (Hospital) referred him to his wife's primary care physician. He said he called his wife's doctor, and his wife's doctor has no information about the COVID-19 Vaccine. He said his wife's doctor could only go by what she knows from her medical background. He said he has a medical background (he clarified he is a pharmacist), and both he and his wife's doctor agreed that the second dose of a vaccine can lead to a more serious reaction, possibly an anaphylactic reaction. He said he needs more information about the COVID-19 Vaccine, and he wanted to report his wife's possible reaction to her first COVID-19 Vaccine dose. He said he wanted to find out if other people had the same reaction his wife had to the first COVID-19 Vaccine dose. He said since his wife's reaction was a mild reaction, did those people who had the same reaction as his wife proceed with a second COVID-19 Vaccine dose. The husband reported that his wife's reaction took a few days to go away. He said in the interim because of the itching his wife was experiencing from her other drugs, his wife's chemotherapy doctor gave her a Medrol dose pack (clarified as Methylprednisolone 10 mg). He said the Medrol dose pack is a cortisone that is taken as a tapered down course of 6, 5, 4, 3, 2, and 1 tablets. He said Medrol dose packs are prescribed for allergic reactions. Reported his wife's reaction was not a serious side effect, in itself, and she recovered quickly. He said while his wife's reaction was just an occurrence, he was very concerned if the reaction occurred in other people, and if those other people took the second COVID-19 Vaccine dose. He said he knows the second dose of a vaccine can precipitate a much more serious reaction. He said the first vaccine dose was considered a sensitizing dose. He said the second vaccine dose can have a serious side effect, if there was a reaction to the first vaccine sensitizing dose. The events did not require visit to emergency room of physician office. The action taken in response to the events for trastuzumab was dose not changed. The patient was recovering from the events.  No follow-up attempts are possible; information about lot/batch number cannot be obtained.