Experienced fatigue all day 18Dec2021.; Then severe migraine manifesting as splitting pain at base of skull & painful pulsating head at 7:28 am 17Dec2021; 101.6F body temperature at 3:19 am 17Dec2021; joint pain; Nausea; 1 episode of vomiting; Chills with shivering; Pain at inj site L Arm starting around 11 PM 16Dec2021; Dose number= 3; This is a spontaneous report from a contactable reporter(pharmacist).   A 47-year-old female patient (not pregnant) received bnt162b2 (BNT162B2), intramuscular, administered in arm left, administration date 16Dec2021 at 10:45 (Batch number: FF2589) at the age of 47 years as dose number 3 (booster), single for COVID-19 immunisation. Relevant medical history included: "GERD" (unspecified if ongoing) and "Migraine" (unspecified if ongoing), notes: Migraines. Concomitant medications included: ZEGERID; ACETAMINOPHEN; IBUPROFEN; RIZATRIPTAN; CALTRATE BONE HEALTH; FISH OIL; VITAMIN C 500MG QD and VITAMIN D3 1000IU QD. Vaccination history included: Bnt162b2 (DOSE 1, SINGLE; Lot Number: EP6955; Administration Location: Left arm; Route of administration: Intramuscular), administration date: 08Apr2021, when the patient was 46 years old, for COVID-19 immunisation and Bnt162b2 (DOSE 2, SINGLE; Lot Number: EP6955; Administration Location: Left arm; Route of administration: Intramuscular), administration date: 29Apr2021, when the patient was 46 years old, for COVID-19 immunisation.  The following information was reported: IMMUNISATION (non-serious) with onset 16Dec2021 at 10:45, outcome "unknown", described as "Dose number= 3"; CHILLS (non-serious) with onset 16Dec2021 at 23:00, outcome "recovered" (19Dec2021), described as "Chills with shivering"; VACCINATION SITE PAIN (non-serious) with onset 16Dec2021 at 23:00, outcome "recovered" (19Dec2021), described as "Pain at inj site L Arm starting around 11 PM 16Dec2021"; BODY TEMPERATURE INCREASED (non-serious) with onset 17Dec2021 at 03:19, outcome "recovered" (19Dec2021), described as "101.6F body temperature at 3:19 am 17Dec2021"; ARTHRALGIA (non-serious) with onset 17Dec2021 at 03:19, outcome "recovered" (19Dec2021), described as "joint pain"; MIGRAINE (non-serious) with onset 17Dec2021 at 07:28, outcome "recovered" (19Dec2021), described as "Then severe migraine manifesting as splitting pain at base of skull & painful pulsating head at 7:28 am 17Dec2021"; NAUSEA (non-serious) with onset 17Dec2021, outcome "recovered" (19Dec2021), described as "Nausea"; VOMITING (non-serious) with onset 17Dec2021, outcome "recovered" (19Dec2021), described as "1 episode of vomiting"; FATIGUE (non-serious) with onset 18Dec2021, outcome "recovered" (19Dec2021), described as "Experienced fatigue all day 18Dec2021". Relevant laboratory tests and procedures are available in the appropriate section. Therapeutic measures were taken as a result of chills, vaccination site pain, body temperature increased, arthralgia, migraine, nausea, vomiting and fatigue. Additional information: Migraine pain so severe unable to get out of bed. Migraine led to nausea and 1 episode of vomiting. Headache continued with less severity as was able to get up & drink and eat 18Dec2021. Additionally taken on 18Dec2021 to manage continuing headache was 2 ibuprofen 4:31 am, rizatriptan 5:55am, 825 mg acetaminophen 9:45 am, rizatriptan at 9:24 pm. All symptoms resolved by morning of Sunday, 19Dec2021, and temperature remained around 98F on Sunday. The patient had no known allergies. The patient did not receive any other vaccines within four weeks prior to the prior to the COVID-19 vaccine. Prior to vaccination, the patient was not diagnosed with COVID-19. Since the vaccination, the patient had not been tested for COVID-19. The events did not result in doctor or other healthcare professional office/clinic visit and emergency room/department or urgent care. Treatment included paracetamol for joint pain and increased body temperature, rizatriptan for migraine and ibuprofen for headache.