PSA level has abruptly risen from 1.33 Dec2017 to 3.17 Jun2021; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP) from medical information team, Program ID.  A 77-year-old male patient received bnt162b2, bnt162b2 omi ba.4-5 (BNT162B2, BNT162B2 OMI BA.4-5), on 07Jun2023 as dose 6 (booster), single (Lot number: GL0087) at the age of 77 years for covid-19 immunisation. The patient's relevant medical history was not reported. There were no concomitant medications. Vaccination history included: bnt162b2 (DOSE 1, Pfizer Covid 19 vaccine: 07Jan2021, Lot: EK9231 (populated in formal field), Expiration: unknown, NDC: unknown), administration date: 07Jan2021, when the patient was 74-year-old, for COVID-19 Immunization; bnt162b2 (DOSE 2, Pfizer covid 19 vaccine: 29Jan2021, Lot: EL8982, Expiration: unknown, NDC: unknown), administration date: 29Jan2021, when the patient was 75-year-old, for COVID-19 Immunization, reaction(s): "PSA level has abruptly risen from 1.33 Dec2017 to 3.17 Jun2021"; bnt162b2 (DOSE 3, Pfizer covid 19 vaccine: 01Oct2021, Lot: EW0185, Expiration: unknown, NDC: unknown), administration date: 01Oct2021, when the patient was 75-year-old, for COVID-19 Immunization; bnt162b2 (DOSE 4, Pfizer covid 19 vaccine: 07Apr2022, Lot: FH8020, Expiration: unknown, NDC: unknown), administration date: 07Apr2022, when the patient was 76-year-old, for COVID-19 Immunization, reaction(s): "From 1.33 in Dec2017 to 3.17 in Jun2021, to 3.71 in Jun2022"; bnt162b2 (DOSE 5, Pfizer covid 19 vaccine: 22Sep2022, Lot: GH9694, Expiration: unknown, NDC: unknown), administration date: 22Sep2022, when the patient was 76-year-old, for Covid-19 immunization. The following information was reported: PROSTATIC SPECIFIC ANTIGEN INCREASED (non-serious), outcome "unknown", described as "PSA level has abruptly risen from 1.33 Dec2017 to 3.17 Jun2021". The event "psa level has abruptly risen from 1.33 dec2017 to 3.17 jun2021" required physician office visit. Relevant laboratory tests and procedures are available in the appropriate section.  Additional information: Reporter's husband PSA level has abruptly risen from 1.33 Dec2017 to 3.17 Jun2021 to 3.71 Jun2022 to 5.99 Aug2023 to 4.93 Sep2023. It was not checked from Dec2017 to Jun2021 because of his age and doctor's policy. This abrupt rise has concerned him. He had 6 Pfizer shots from Jan2021 to Jun2023. He had recently read articles on (withheld) about the possibility that the COVID vaccine could cause temporary spikes in PSA levels. Caller stated, patient noticed he had a history of pretty low PSA and it took a pretty big jump, a jump a year ago and bigger jump this year, he was trying to figure out what causing this, and stated it was possible to be having cancer causing this but the only thing that he had different was, he did have 6 Pfizer covid shots, during the last few years (from Jan2021 to Jun2023), and his last two PSA levels he had were roughly two months after a Pfizer shot, and so he did some research, where he found on a you tube video, CBS palm beach urologist that had several patients with sudden spikes in PSA and recently had received covid vaccine. Wasn't suggesting any connection between the pfizer shot or any other shot causing cancer, just a temporary spike in PSA, because it would go back to normal. It was just a temporary spike. Another video by (Name withheld), who is a jack pot took the same interview and cut parts of it off and put out something saying that the covid shots cause prostate cancer, and sterility, and so on and so on, the doctor did not say this in the interview and the doctor feels it's a temporary elevation in the PSA levels. He received his shots at the (withheld). Thought all were administered in his left arm. At his age the PSA numbers were not concerning but trends were. The big difference was in Jun2022 where his PSA level was 3.71 and then in Aug2023 his PSA level was 5.99. Last PSA was 4.93 in 12Sep2023, ran 2.5 miles a day.; Sender's Comments: Linked Report(s) : US-PFIZER INC-202300302210 Same patient/same event, different vaccine dose;US-PFIZER INC-202300302450 Same patient/same event, different vaccine dose;