left knee gave out and buckled, and was hospitalized for 4 days; If it's in bed and put a pillow over it and is laying in bed, with some difficulty can lift it and it's normally the strong leg; Kinda like the whole left side of the body has been affected; Certain damage to the muscle; Weakness; Pain in the left arm; Really tired; This spontaneous case was reported by a consumer (subsequently medically confirmed) and describes the occurrence of JOINT INJURY (left knee gave out and buckled, and was hospitalized for 4 days) in a 67-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 002A21A and 010M20A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     Concurrent medical conditions included Ehlers-Danlos syndrome. Concomitant products included RIVAROXABAN (XARELTO), VALETHAMATE BROMIDE (VALOSIN), DIGOXIN, EZETIMIBE, CICLOSPORIN (RESTASIS), SPIRONOLACTONE, SOTALOL, TRAZODONE, LORATADINE, FOLIC ACID (FOLATE), CYANOCOBALAMIN (VITAMIN B12 [CYANOCOBALAMIN]), MAGNESIUM TAURATE, MELATONIN, VITAMIN C [ASCORBIC ACID] and COLECALCIFEROL (VITAMIN D3) for an unknown indication.   On 05-Feb-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 05-Mar-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. On an unknown date, the patient experienced JOINT INJURY (left knee gave out and buckled, and was hospitalized for 4 days) (seriousness criterion hospitalization), MOBILITY DECREASED (If it's in bed and put a pillow over it and is laying in bed, with some difficulty can lift it and it's normally the strong leg), FEELING ABNORMAL (Kinda like the whole left side of the body has been affected), MUSCLE INJURY (Certain damage to the muscle), ASTHENIA (Weakness), VACCINATION SITE PAIN (Pain in the left arm) and FATIGUE (Really tired). The patient was treated with Physical therapy for Mobility decreased. At the time of the report, JOINT INJURY (left knee gave out and buckled, and was hospitalized for 4 days), MOBILITY DECREASED (If it's in bed and put a pillow over it and is laying in bed, with some difficulty can lift it and it's normally the strong leg), FEELING ABNORMAL (Kinda like the whole left side of the body has been affected), MUSCLE INJURY (Certain damage to the muscle), ASTHENIA (Weakness), VACCINATION SITE PAIN (Pain in the left arm) and FATIGUE (Really tired) outcome was unknown.        For mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular), the reporter did not provide any causality assessments.   Patient had a rare Genetic Disease,Ehlers Danlos Syndrome.,that affected the connective tissue and collagen in the body has been clinically diagnosed. Treatment information in response to events was not provided. Other concomitant medication included Metocapuilan.  Very limited information regarding these events have been provided at this time. Patient's age and history of Ehlers-Danlos syndrome may be confounding factors to the event Knee Injury. No further information is expected.   This case was linked to MOD-2021-222975 (Patient Link).; Sender's Comments: Very limited information regarding these events have been provided at this time. Patient's age and history of Ehlers-Danlos syndrome may be confounding factors to the event Knee Injury. No further information is expected.