lethargy; Red face, hot face when waking up Gray spot on forehead; Red face, hot face when waking up/Feeling of warmth facial; Gray spot on forehead; was tired and wiped out; This is a spontaneous report from a contactable nurse or other health care professional. This Nurse reported on behalf of a physician for an 80-year-old female patient. A 80-years-old female patient received second dose of bnt162b2 (PFIZER-BIONTECH COVID-19 VACCINE, Formulation: Solution for injection, Lot number: EL9266), via an intramuscular route of administration (at the age of 80-years), ad-ministered in deltoid right on 12Feb2021 at 09:30 as dose 2, 0.3 ml single for COVID-19 immunization. Medical history included , rotator cuff repair from 2010 to an unknown date , cataract from 16May2016 to an unknown date Surgeries, Both Eyes , total shoulder replacement from 02Jul2019 to an unknown date , adenoidectomy, vertigo, diabetes from an unknown date and unknown if ongoing. The patient had the family medical history of disorder of thyroid gland from an unknown date and unknown if on-going. The concomitant medication was not reported. The vaccination facility type was reported as other, public health department.The patient did not receive any recent vaccines for any other conditions prior to the event being reported. The patient did not receive any recent vaccines for SARS-CoV2 other than Pfizer-BioNTech COVID-19 Vaccine prior to the event being reported. The patient did not received any other vaccines around the time of Pfizer-BioNTech COVID-19 Vaccine vaccination. The patient historical vaccine included first dose of bnt162b2 (PFIZER-BIONTECH COVID-19 VACCINE, Formulation: Solution for injection, Lot number: EL8982), via an intramuscular route of administration, administered in deltoid right on 15Jan2021 at 13:00 as dose 1, 0.3 ml single for COVID-19 immunization. On 22Feb2021 at 09:00, the patient experienced red face, hot face when waking up gray spot on fore-head, red face, hot face when waking up/feeling of warmth facial, was tired and wiped out, gray spot on forehead. On an unspecified date, experienced lethargy. It was further reported by the patient that I am 80 years old, I have been a very active person taking of my own yard and flower garden , now I am very tired ,what can I do to make the tired , no energy , feelings go away. On 22Feb2021, the patient experienced hot and red face on left side when wake up. In 2021, the hot and red face on left side when got out from shower, when wake up and warm to touch resolved. Covid-19 vaccine was also considered suspect. The patient was treated with Benadryl. The treatment was received for all the adverse events with benadryl 25mg 1/2 tab twice days for 3 days. The adverse events resulted in physician office visit. The patient was not seen in the Emergency Department. The patient was not admitted to hospitalized. The patient was not admitted to an Intensive Care Unit. No Multi organ involvement and no other symptoms/signs. The patient underwent lab tests and procedures which included blood pressure measurement: unknown on 03Jan2021, colonoscopy: unknown on 02Jul2019, heart rate and oxygen saturation: unknown on an unspecified date, mammogram: unknown on 16Nov2016. The clinical outcome for the event was tired and wiped out was reported as not recovered while for all the other events was reported as unknown.  The Pfizer product had a casual effect to the adverse event.  No follow-up attempts are possible. No further information is expected