severe pain in my vagina and found it to be ulcerated in 3 spots; aphthous ulcers; severe pain in my vagina and found it to be ulcerated in 3 spots; strong immune response; severely debilitating joint pain; I was febrile; required hands-on assistance for mobility; This is a spontaneous report received from contactable reporter(s) (Other HCP). The reporter is the patient.  A 34 year-old female patient (not pregnant) received bnt162b2 (BNT162B2), administered in arm left, administration date 17Feb2022 15:15 (Lot number: 3303680) at the age of 34 years as dose 3 (booster), single for covid-19 immunisation. Relevant medical history included: "hypothyroidism" (unspecified if ongoing); "ADHD" (unspecified if ongoing); "Covid-19" (unspecified if ongoing), notes: if covid prior vaccination: Yes. The patient took concomitant medications. Past drug history included: Codeine, reaction(s): "known allergies: codeine". Vaccination history included: Bnt162b2 (Dose Number: 2, Batch/Lot No: EL3248, Location of injection: Arm Left, Vaccine Administration Time: 01:15 PM), administration date: 08Jan2021, when the patient was 33 years old, for COVID-19 Immunization; Bnt162b2 (Dose Number: 1, Batch/Lot No: EK5730, Location of injection: Arm Left, Vaccine Administration Time: 03:00 PM), administration date: 17Dec2020, when the patient was 33 years old, for COVID-19 Immunization. The following information was reported: IMMUNE SYSTEM DISORDER (non-serious) with onset 19Feb2022 15:00, outcome "not recovered", described as "strong immune response"; ARTHRALGIA (non-serious) with onset 17Feb2022 15:00, outcome "recovered" (19Feb2022 03:15), described as "severely debilitating joint pain"; VULVOVAGINAL PAIN (non-serious), VAGINAL ULCERATION (non-serious) all with onset 19Feb2022 15:00, outcome "not recovered" and all described as "severe pain in my vagina and found it to be ulcerated in 3 spots"; APHTHOUS ULCER (non-serious) with onset 19Feb2022 15:00, outcome "not recovered", described as "aphthous ulcers"; PYREXIA (non-serious) with onset 17Feb2022 15:00, outcome "recovered" (19Feb2022 03:15), described as "I was febrile"; MOBILITY DECREASED (non-serious) with onset 17Feb2022 15:00, outcome "recovered" (19Feb2022 03:15), described as "required hands-on assistance for mobility". The events "strong immune response", "severely debilitating joint pain", "i was febrile", "required hands-on assistance for mobility" were evaluated at the emergency room visit. The events "severe pain in my vagina and found it to be ulcerated in 3 spots", "aphthous ulcers" and "severe pain in my vagina and found it to be ulcerated in 3 spots" were evaluated at the physician office visit and emergency room visit. Therapeutic measures were taken as a result of immune system disorder, arthralgia, vulvovaginal pain, aphthous ulcer, vaginal ulceration, pyrexia, mobility decreased. Patient received 10day course of valacyclovir; PRN 500mg Naproxen.  Additional info: Patient stated, r 36 hours post-injection I was febrile with severely debilitating joint pain and required hands-on assistance for mobility. Around hour 48 I noticed severe pain in my vagina and found it to be ulcerated in 3 spots. I sought medical attention at a GYN urgent care who found patient to have aphthous ulcers and prescribed an anti-viral; the practitioner felt it was related to the strong immune response from vaccination and was also seen in patients with Mono. Facility type vaccine: Workplace clinic. No other vaccine in four weeks. Other medications in two weeks: OTC  No follow-up attempts are possible. No further information is expected.