Feel bad; Her infusions of Rituximab and Gammagard made the Pfizer Covid-19 "null and void"; This is a spontaneous report from a contactable consumer (patient) via medical information team. A 69-years-old female patient received second dose of bnt162b2 (PFIZER-BIONTECH COVID-19 mRNA VACCINE, solution for injection, Lot number: EP6955) via an unspecified route of administration, administered in left arm shoulder on 26Mar2021 at 09:25 (at the age of 69 years) as dose 2, single; received first dose of bnt162b2 (PFIZER-BIONTECH COVID-19 mRNA VACCINE, solution for injection, Lot number: EN6203) via an unspecified route of administration, administered in left arm shoulder on 05Mar2021 at 09:25 (at the age of 69 years) as dose 1, single both for covid-19 immunisation; rituximab (MAUNFACTURER UNKNOWN), via an unspecified route of administration from 23Feb2021 (Batch/Lot number was not reported) to 16Mar2021, as unknown other than 4 doses given via infusion once weekly for 4 weeks on Tuesdays for low grade lymphoma; immunoglobulin human normal (GAMMAGARD), via an unspecified route of administration from an unspecified date other than about 3.5 years (Batch/Lot number was not reported) as unknown dose 5 infusions-1 infusion for 5 days in a row once a week every month for dermatomyositis. Medical history included ongoing dermatomyositis onset almost 4 years ago, ongoing hypertension onset at least 5 years ago , ongoing diabetes mellitus onset at least 5 years ago , ongoing high cholesterol onset at least 5 years ago , low grade lymphoma from Jan2021 and ongoing, ongoing little overweight. Concomitant medicatios included lisinopril taken for hypertension from an unspecified start date and ongoing; hydrochlorothiazide taken for hypertension from 2021 and ongoing; prednisone taken for dermatomyositis from an unspecified start date and ongoing; metformin taken for diabetes mellitus from an unspecified start date and ongoing; pravastatin taken for high cholesterol; apoaequorin (PREVAGEN [APOAEQUORIN]) taken for an unspecified indication. Patient family medical history relevant to adverse events included father died of massive heart attack found out had kidney cancer when they did the autopsy; mother was a testimony to only the good die young, she was 92 years old and still miserable. Daughter has melanomas. Patient had no history of all previous immunization with the Pfizer vaccine considered as suspect. No additional vaccines administered on same date of the pfizer suspect. Patient had no prior vaccinations within 4 weeks prior to the first administration date of the suspect vaccine and had no adverse events following prior vaccinations. It was reported that the patient received both doses of the Pfizer Covid-19 vaccine series (first dose 05Mar2021, second dose 26Mar2021) and had 4 infusions of Rituximab. She had to go see a different provider and they put her into a study and the study was for how the Rituximab treatment she got worked with the Pfizer Covid Vaccine. Part of that study was that she got tests that showed she does not have any protection against Coronavirus, has no antibodies. She had testing a week ago yesterday (17Jun2021) and revealed that she had no antibodies and she "was not protected from Covid-19". She stated she was involved in a study at hospital and her doctor told her they "are pretty sure" that her infusions of Rituximab and Gammagard made the Pfizer Covid-19 "null and void". Patient just feel bad because here she was susceptible again and just don't want to get sick. The doctors are all differing but they are pretty sure the Rituximab was what made the Pfizer Covid Vaccine ineffective. She asked if this could be related to Rituximab or concomitant product Gammagard infusions; and if it was recommended or not to get additional Pfizer Covid Vaccine dose relative to this information. Patient experienced no adverse reactions to the Pfizer Covid Vaccine, no reaction at all, not even a site reaction. Patient informed that after the Rituximab therapy her Dermatomyositis symptoms started coming back so she went back on the IVIG therapy: Gammagard. She previously was getting Prevagen before the Gammagard. It was reported serious no. Regarding testing/investigations patient reported that she had 3 tests done a week ago yesterday; but when going through the testing information she determined she thought she only had 2 tests done, that maybe the third she thought she had was just a combination of those two test results. The patient underwent lab tests and procedures which included CBC with auto differential: unknown on 17Jun2021, Coronavirus IgG and IgA: does not have any protection against coronavirus; no antibodies on 17Jun2021. The outcome of the events was unknown.  Follow-up attempts are completed. No further information is expected.