lips started tingling; lips felt still numb; allergic reaction; my arms felt like they are burning; rash/really red; She got the rash/she felt little bluish; tired; rash; This is a spontaneous report from a contactable consumer (patient). A 54-year-old female patient received the third dose of BNT162b2 (PFIZER-BIONTECH COVID-19 VACCINE; lot number: FE3590), intramuscularly in the left arm on 16Oct2021 at 09:30 (at the age of 54-years-old) at dose 3 (booster), single for COVID-19 immunisation. Medical history included rash before from certain drug or stuff, like she could not take Sulphur drug and was allergic to calamari, symptoms in her thumbs in Sep2021. Concomitant medications included acyclovir, influenza vaccine (FLU) in Oct2021 at single dose for flu immunization, vitamins nos, steroid shot in her thumb for those symptoms in her thumbs. The patient received first and second dose of BNT162b2 on unspecified dates for COVID-19 immunization. Patient had the booster shot, the Pfizer booster shot on 16Oct2021 like 9:30 in the morning and she thought may be 4 hours later, she had a rash. She had that rash before from certain drug or stuff, like she could not take Sulphur drug and was allergic to calamari. Patient went to the hospital cause it was really red, and they prescribed her to take 3 pills of 60 mg of prednisone. Patient did not take it yet, so she was feeling well. Then the day before the report, on 17Oct2021, she ended up feeling a little better and the red color disappearing. On 18Oct2021, she was sitting outside and her arms were covered but her arms felt like they were burning and the rash felt like it was on her arm and a little on her chest and stuff and then her lips started tingling, like allergic reaction and so she went to the pharmacist and she was breathing and everything ok so obviously she was going to be ok but she went to the pharmacist and got BENADRYL cause it helped with that and she did fill the prescription for the prednisone but she did not know whether she had to take it or not, the day after. About her weight, patient stated it was 140 pound, well 130 pounds 140 yes; she thought it was like 130, she thought 138, 137; she did not know. Patient stated that she got the rash on 16Oct2021, she felt little bluish or whatever nothing too bad at all just tired, she was just tired, the first one or second one was little more bluish (unspecified). About concomitant medications, patient reported that she was taking just vitamins and acyclovir but she did not take it on that Saturday and was given a steroid shot in her thumb for those symptoms in her thumbs for like 3 to 4 weeks prior the report so it did not spread it out, she got a flu shot a couple weeks prior the report, in Oct2021. Patient stated that at the time of the report it felt a little warm, it seemed like it disappeared a little bit, but it was her lips felt tingly that was why she took BENADRYL, but she did not know if she had to take this prednisone or not, if it went against the vaccine or what. Rash seemed like it was subsided a little bit, she had a little on the neck and it was not burning as much but her lips felt still numb but like tingling; they said at the pharmacy it was like anything it was going to happen like you were not breathing or anything like that, that would happen right away, you did not get it 2-3 days later. About treatment, she said that instead of taking prednisone they wanted to give her, she took BENADRYL and then she got the script for the prednisone; pharmacist recommended her to take it, she said you just could have a reaction to it and to get the reaction out of your body just take the steroid for 5 days. The patient was recovering from rash/really red, had not recovered from lips started tingling, lips felt still numb, the outcome of the other events was unknown.   Follow-up (22Oct2021): Follow-up attempts are completed. No further information is expected.