This spontaneous case was reported by a patient and describes the occurrence of CELLULITIS (received Covid vaccine she has had 3-4 episodes of cellulitis after bites/The oval shape with red mark around it with the brown bite mark in the middle and had a small red spot above the ankle which became swollen and inflamed, and developed a severe) in an 83-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 038A22A, 939904, 031L20A and 028L20A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below. The patient's past medical history included Cellulitis (notes: Around a year ago sometime after primary and second dose she had a bite which progressed to cellulitis She had to sought medical treatment) in 2021. Concurrent medical conditions included Gluten sensitivity (it was not an allergy.), Allergy to antibiotic (Cipro) and Drug allergy (Crestor). Concomitant products included VITAMINS NOS for an unknown indication. On 17-Jan-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 14-Feb-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 28-Oct-2021, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 17-May-2022, received fourth dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. In May 2022, the patient experienced HYPOAESTHESIA (she stated that the left side of my face feels tight, I can feel it if I touch it, but it does have a sensation of numbness). On 19-May-2022, after starting mRNA-1273 (Moderna COVID-19 Vaccine), the patient experienced BLEPHAROSPASM (she experienced eye twitching pretty severe/both the eye and puffy vein twitching), PERIORBITAL SWELLING (spot that is puffy under the left eye) and VASODILATATION (also a spot that is puffy under the left eye which she describes as a puffy vein). On an unknown date, the patient experienced CELLULITIS (received Covid vaccine she has had 3-4 episodes of cellulitis after bites/The oval shape with red mark around it with the brown bite mark in the middle and had a small red spot above the ankle which became swollen and inflamed, and developed a severe) (seriousness criterion medically significant). At the time of the report, CELLULITIS (received Covid vaccine she has had 3-4 episodes of cellulitis after bites/The oval shape with red mark around it with the brown bite mark in the middle and had a small red spot above the ankle which became swollen and inflamed, and developed a severe) was resolving and BLEPHAROSPASM (she experienced eye twitching pretty severe/both the eye and puffy vein twitching), PERIORBITAL SWELLING (spot that is puffy under the left eye), VASODILATATION (also a spot that is puffy under the left eye which she describes as a puffy vein) and HYPOAESTHESIA (she stated that the left side of my face feels tight, I can feel it if I touch it, but it does have a sensation of numbness) outcome was unknown. Concomitant medication reported as Low dose beta blocker and Antibiotics. Patient did not have a positive Covid test. On 19-May-2022, 2 Days after receiving her second booster vaccine, she experienced eye twitching, pretty severe, also a spot that was puffy under the left eye which she described as a puffy vein. The patient stated that when she looked in the mirror, she can see both the eye and puffy vein twitching. The twitching was on and off.  Additionally, she stated that the left side of her face felt tight, she can feel it if she touches it, but it did not have a sensation of numbness. She had not sought medical treatment but had an upcoming appointment with her eye doctor for something else, where she will be discussing this. Around 22-May-2022, She had a small red spot above the ankle which became swollen and inflamed and developed a severe reaction. She went to Urgent care and was prescribed antibiotic and steroid. She followed up with the dermatologist because it looked bad. The Physician assistant had her stop taking the antibiotic because it was causing her stomach problems and burning in her throat. The oval shape with red mark around it with the brown bite mark in the middle was still there but was healing. She asked them if they have seen people who have developed a hypersensitivity after Covid vaccines, the PA told her that they were seeing more of sensitivity but did not mention vaccine by name or the manufacturer. She also went online and typed eye twitching after Covid vaccine and people were reporting that but there was no mention of any vaccine by name or the manufacturer. Company Comment: This is a spontaneous case concerning an 83 year-old, female patient with a history of cellulitis after first and second dose of vaccination, who experienced the serious (due to medically important condition) unexpected, event of cellulitis. The event occurred after the fourth dose of mRNA-1273 vaccine, second booster dose. The patient reported that since receiving the COVID vaccine she had 3-4 episodes of cellulitis after bites. She went to the urgent care and was prescribed with antibiotics and steroids, the same month of vaccination. The outcome was reported as recovering. The mentioned medical history remains as a confounder. The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report. This case was linked to MOD-2022-587428, MOD-2022-587447, MOD-2022-587455 (Patient Link). Sender's Comments: This is a spontaneous case concerning an 83 year-old, female patient with a history of cellulitis after first and second dose of vaccination, who experienced the serious (due to medically important condition) unexpected, event of cellulitis. The event occurred after the fourth dose of mRNA-1273 vaccine, second booster dose. The patient reported that since receiving the COVID vaccine she had 3-4 episodes of cellulitis after bites. She went to the urgent care and was prescribed with antibiotics and steroids, the same month of vaccination. The outcome was reported as recovering. The mentioned medical history remains as a confounder. The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report.