GRAND MAL SEIZURES; BIG GREENISH PURPLISH THING COMING OUT OF SINUSES LIKE A MUSHROOM; ISSUES WITH MOTOR SKILLS; SHAKY LEGS, KNEES, HANDS AND ARMS; DIFFICULTY WALKING; DIFFICULTY LIFTING LEGS, SPECIALLY LEFT ONE; SHE KEEPS FALLING; TINGLING IN HANDS, PROGRESSED TO OTHER HAND, THEN FEET AND LEGS; AWFUL MIGRAINES; This spontaneous report received from a patient concerned a 36 year old female. The patient's height, and weight were not reported. The patient's past medical history included: Had a seizure as infant due to fever, and concurrent conditions included: uterine cyst, stopped alcohol consumption 2 years ago, and quit smoking on SEP-2021, and other pre-existing medical conditions included: The patient had no known allergies, was not pregnant at the time of the reporting. The patient had history of drug abuse or illicit drug usage (marihuana occasionally). The patient received covid-19 vaccine ad26.cov2.s (suspension for injection, route of admin not reported, batch number: 1820095 expiry: UNKNOWN) dose was not reported, frequency 1 total, administered on 07-MAY-2021 to right arm for prophylactic vaccination. Dose series number was 1. No concomitant medications were reported.  On JUN-2021, the patient experienced awful migraines. During summer time the patient had a big greenish purplish thing coming out of her sinuses, "like a mushroom". The patient stated that she thought it was a bad sinus infection but that after doing research, the patient thought it could be related. After that, migraines almost completely went away. On SEP-2021, the patient experienced first tingling in right hand for "quite a while" which then progressed to her other hand, then feet and legs. The patient stated that she thought it could be nerve damage. After her hand started tingling, she experienced seizures. The patient had complained of seizures in her sleep (4-5 at night). On OCT-2021, the patient was hospitalized for grand mal seizures (her mother used to have grand mal seizure). The patient was hospitalized for 3 days due to seizure. The patient was taking anti seizure medications. The patient underwent Magnetic resonance imaging (MRI) and different exams performed including Electromyography (EMG) muscle test for which results were not reported. On an unspecified date, the patient had issues with motor skills, shaky legs, knees, hands and arms (cant write or hold the phone anymore), difficulty walking, difficulty lifting legs, specially left one, and she keeps falling. The patient stated as if her brain was telling my leg to move but not responding and that it looked like if she had Parkinson's. The action taken with covid-19 vaccine ad26.cov2.s was not applicable. The patient recovered from awful migraines, and big greenish purplish thing coming out of sinuses like a mushroom, had not recovered from tingling in hands, progressed to her other hand, then feet and legs, shaky legs, knees, hands and arms, difficulty walking, and difficulty lifting legs, specially left one, and the outcome of issues with motor skills, grand mal seizures and she keeps falling was not reported. This report was serious (Hospitalization Caused / Prolonged).; Sender's Comments: V0: 20211225718-COVID-19 VACCINE AD26.COV2.S-Grand mal seizures. This event(s) is considered unassessable. The event(s) has a compatible/suggestive temporal relationship, is unlabeled, and has unknown scientific plausibility. There is no information on any other factors potentially associated with the event(s).