blister spots on the left waistline; flu-like symptoms; occupational airborne exposure; fatigue; nasal passage burning sensation; sinusitis; sore throat; face is chapped; torso is itchy; tracking rash along her left jaw bone; burning; stinging; tingling; pimple-like rash on both her waist line; This case was reported by a pharmacist via call center representative and described the occurrence of rash in a 61-year-old female patient who received Herpes zoster (Shingrix) for prophylaxis.   On 31st January 2019, the patient received Shingrix. On 2nd February 2019, 2 days after receiving Shingrix, the patient experienced rash, burning sensation, stinging and tingling. In November 2019, the patient experienced nasal burning, sinusitis, sore throat, chapped skin and pruritus. On an unknown date, the patient experienced pimple-like rash, blistery rash, influenza-like symptoms, occupational exposure while administering product and fatigue. On 3rd February 2019, the outcome of the rash, burning sensation, stinging and tingling were recovered/resolved. On an unknown date, the outcome of the pimple-like rash was recovered/resolved and the outcome of the blistery rash, influenza-like symptoms, nasal burning, sinusitis, sore throat, chapped skin, pruritus, occupational exposure while administering product and fatigue were unknown.   The reporter considered the rash, burning sensation, stinging, tingling, pimple-like rash, blistery rash, influenza-like symptoms, nasal burning, sinusitis, sore throat, chapped skin, pruritus and fatigue to be possibly related to Shingrix.  Additional details were provided as follows: The patient who was also a pharmacist stated after her pharmacy started providing the Shingrix vaccine to customers, she started having certain reactions. She has not received the Shingrix vaccine and there has not been any direct exposure.  She states around she vaccinated a customer with the Shingrix vaccine and around she observed burning, stinging, tingling, tracking rash along her left jaw bone and resolved. After she provided Shingrix vaccine in her pharmacy on a Saturday and by around Sunday she noticed a pimple-like rash on both her waist line which resolved in 48-72 hrs.Recently after she provided a Shingrix vaccination to a patient, and later that day she had 3-10 blister spots on the left waistline. The dermatologist took cultures biopsies of these blisters and they were negative for any herpes virus and the doctor diagnosed the condition as idiopathic. The pharmacist stating she gets flu-like symptoms when her pharmacy provides the Shingrix vaccine, that is even when she was not providing direct Shingrix vaccination to the customers. She gets flu-like symptoms with nasal passage burning sensation, sinusitis, sore throat, fatigue. She states she thinks she was experiencing some type of immune response to the occupational airborne exposure of the Shingrix vaccine. She was stating at the time of reporting her face was chapped and her torso was itchy which she attributes to the Shingrix vaccine occupational airborne exposure. In general, she has stopped vaccinating customers with the Shingrix vaccine unless it was necessary at the pharmacy. The reporter consented to follow up.      Lab Comments: negative for any herpes virus