This case was reported in a literature article and described the occurrence of immobile in a 85-year-old male patient who received Herpes zoster (Herpes Zoster vaccine) for prophylaxis. Concurrent medical conditions included hypertension and type ii diabetes mellitus. On an unknown date, the patient received Herpes Zoster vaccine at an unknown dose. On an unknown date, less than a day after receiving Herpes Zoster vaccine, the patient experienced immobile (serious criteria hospitalization, disability and GSK medically significant), general body pain (serious criteria hospitalization), weakness (serious criteria hospitalization), fever (serious criteria hospitalization), acute renal insufficiency (serious criteria hospitalization and GSK medically significant), dehydration (serious criteria hospitalization) and sinus pause (serious criteria hospitalization and GSK medically significant). The patient was treated with ceftriaxone and prednisone. On an unknown date, the outcome of the immobile, general body pain, weakness, fever, acute renal insufficiency, dehydration and sinus pause were unknown. The reporter considered the immobile, general body pain, weakness, fever, acute renal insufficiency, dehydration and sinus pause to be possibly related to Herpes Zoster vaccine. Additional information was provided. This case was reported in a literature article and described occurrence of immobility in a 85-year-old male who was vaccinated with unspecified herpes zoster subunit (HZSU) vaccine (manufacturer unknown) for prophylaxis. The patient was independent, community living older adult. The patient had hypertension (HTN) and diabetes mellitus II (DM). No information on patient's family history or concomitant medication was provided. On an unspecified date, at the age of 85, the patient received unspecified herpes zoster subunit vaccine during the annual visit (administration route and site unspecified, dosage unknown; batch number not provided). On an unspecified date, same day after vaccination, while driving to home, the patient experienced body aches. Within 2 days, the pain worsened, and patient became very weak. Subsequently, the patient presented to emergency. In emergency room, the patient was found to be febrile with a white blood cells (WBC) of 13. The patient was treated with ceftriaxone and admitted for a possible infection. Work up found no infection so antibiotics were not continued. Prednisone was added with no improvement. As no other reversible cause was found for patient symptoms, the patient was discharged after a few days to a subacute rehabilitation facility (SAR). 10 days later, the patient was again admitted with acute renal insufficiency. The patient was dehydrated and much weaker. The patient was again worked up with the only new finding being a pause in the heart rate. the patient remained weak despite pacer placement, so the patient was again discharged to SAR where the patient became quickly immobile. Patient continued to decline and was transferred out of state 2 months later to be closer to patient's son who could assist the patient with care oversight. This case has been considered as serious due to hospitalisation. The author commented "This case describes a rare reaction in a previously independent, community living older adult. Despite his age and comorbid status, this patient lived alone and was fully independent. This rare reaction led to immobility and full physical dependence forever changing his life. Practitioners should be aware of this possible rare reaction given guidelines recommend shingles vaccination of all persons over 50 years of age". Lab Comments: Lab tests were performed on unspecified date.