Feeling joint pain and inflammation; overall lowenergy; weight loss (23 lbs only in a few weeks)/unintentional loss of weight; he was not feeling good/ patient felt bad and went to ER; Feeling joint pain/shoulder pain in rotator cuff; This spontaneous case was reported by a patient and describes the occurrence of ARTHRITIS (Feeling joint pain and inflammation), ASTHENIA (overall lowenergy), WEIGHT DECREASED (weight loss (23 lbs only in a few weeks)/unintentional loss of weight), FEELING ABNORMAL (he was not feeling good/ patient felt bad and went to ER) and ARTHRALGIA (Feeling joint pain/shoulder pain in rotator cuff) in a 68-year-old male patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 001B21A and 006M20A) for COVID-19 vaccination.     The patient did not have any allergies to medications, food and other products. The patient has never had COVID positive test or diagnosis. No other vaccines were given within 1 month prior to Moderna COVID-19 vaccine.  Concurrent medical conditions included MGUS (3 years ago, Recent change in status-some improvement). Concomitant products included ACETYLSALICYLIC ACID (BABY ASPIRIN), VITAMIN D NOS, AMLODIPINE and FAMOTIDINE for an unknown indication.   On 14-Feb-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 14-Mar-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. On 28-Oct-2021, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. In January 2022, the patient experienced ARTHRITIS (Feeling joint pain and inflammation), ASTHENIA (overall lowenergy), WEIGHT DECREASED (weight loss (23 lbs only in a few weeks)/unintentional loss of weight), FEELING ABNORMAL (he was not feeling good/ patient felt bad and went to ER) and ARTHRALGIA (Feeling joint pain/shoulder pain in rotator cuff). At the time of the report, ARTHRITIS (Feeling joint pain and inflammation), ASTHENIA (overall lowenergy), WEIGHT DECREASED (weight loss (23 lbs only in a few weeks)/unintentional loss of weight), FEELING ABNORMAL (he was not feeling good/ patient felt bad and went to ER) and ARTHRALGIA (Feeling joint pain/shoulder pain in rotator cuff) was resolving.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): In January 2022, Blood test: abnormal (abnormal) Blood tests were not good. In 2022, Blood sodium: very low (Low) Very low. In 2022, Whole body scan: result not provided made a body scan to discard brain cancer, but it wasn't.         The patient received 1st booster on 28-Oct-2021. After 1st and 2nd vaccine patient did not experience any symptoms. After 1st booster patient stated there was some side effects that could be related to the vaccine. Patient went to ER once because the patient felt bad and doctors told the patient's sodium was very low, made a body scan to discard brain cancer, but it wasn't. Patient was given only Vitamin D .  company comment This spontaneous case concerns a 68-year-old, male patient with relevant concurrent medical condition of Monoclonal gammopathy of unknown significance (MGUS) since 3 years, who experienced the unexpected, non-serious of arthritis (feeling joint pain and inflammation), along with other non-serious events of Asthenia and Arthralgia, on an unknown date, about 2 months after receiving the 3 dose of mRNA-1273 vaccine, in the covid 19 vaccination series. The primary 2 doses were also given with Moderna vaccines at an interval of 1 month, with the last dose given about 7 months prior to the 3 dose, with no adverse events reported to the primary doses of Moderna. Blood tests were reported as not good (abnormal), Blood sodium was very low. Whole body scan was done to exclude brain cancer. Results of scan were not provided. Age of the patient and Concurrent medical condition of Monoclonal gammopathy of unknown significance (MGUS) are confounders. Details of clinical course, results of labs and diagnostic investigations and treatment details were not provided. The event was resolving. The benefit-risk relationship of mRNA-1273 Vaccine is not affected by this report. Sender's Comments: This spontaneous case concerns a 68-year-old, male patient with relevant concurrent medical condition of Monoclonal gammopathy of unknown significance (MGUS) since 3 years, who experienced the unexpected, non-serious  of arthritis (feeling joint pain and inflammation), along with other non-serious events of Asthenia and Arthralgia, on an unknown date, about 2 months after receiving the 3 dose of mRNA-1273 vaccine, in the covid 19 vaccination series. The primary 2 doses were also given with Moderna vaccines at an interval of 1 month, with the last dose given about 7 months prior to the 3 dose, with no adverse events reported to the primary doses of Moderna. Blood tests were reported as not good (abnormal), Blood sodium was very low. Whole body scan was done to exclude brain cancer. Results of scan were not provided. Age of the patient and Concurrent medical condition of Monoclonal gammopathy of unknown significance (MGUS) are confounders. Details of clinical course, results of labs and diagnostic investigations and treatment details were not provided. The event was resolving. The benefit-risk relationship of mRNA-1273 Vaccine is not affected by this report.