memory issues; tired and could not perform my normal activities; has brain fog; tightness and discomfort in chest; voice changed from her throat closing up; blood pressure was higher than usual.; shotness of breath; throat burning then traveled to chest; pain and pressure in her chest and throat; pain and pressure in her chest and throat; pain and pressure in her chest and throat; 5 min after the shot, severe sharp headache; This spontaneous case was reported by a consumer and describes the occurrence of MEMORY IMPAIRMENT (memory issues), FEELING ABNORMAL (has brain fog), THROAT IRRITATION (throat burning then traveled to chest), CHEST PAIN (pain and pressure in her chest and throat) and CHEST DISCOMFORT (pain and pressure in her chest and throat) in a 49-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch no. 022C21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     The patient's past medical history included Gastritis on 05-Sep-2017, Smoker, Hay fever, Hypersensitivity reaction, Ulcer (Duodenal and anastomotic ulcer), Arthritis on 10-Oct-2014, Emergency care (at the ER for six hours), Degenerative bone disease (both knees.) and Gastric bypass on 19-Jul-2021. Concurrent medical conditions included Allergy to chemicals, Drug allergy (Doxycycline, Covid-19 vaccine allergy), Latex allergy (Rash, redness swelling burning pain.) since 17-Jul-2020, Shellfish allergy (Anaphylaxis, Hives, horse voice ,dizziness, throat swelling, panic .) since 15-Jan-2017, Seasonal asthma (SOB), Food allergy (patient experience headache, rash, throat pressure pain brings asthma.) since 10-Feb-2015, GERD and Acid reflux (oesophageal) (aggravated by allergic reaction to vaccine.) since 05-Sep-2017. Concomitant products included MULTIVITAMINS [VITAMINS NOS] from 12-Feb-2017 to an unknown date, IRON from 12-Feb-2017 to an unknown date and CALCIUM from 12-Feb-2017 to an unknown date for Deficiency vitamin, PHENTERMINE HCL from 15-Nov-2020 to an unknown date for Metabolic disorder, PANTOPRAZOLE, CITRIC ACID MONOHYDRATE, POTASSIUM CITRATE MONOHYDRATE (POTASSIUM CITRATE CITRIC ACID), SUCRALFATE, SALBUTAMOL SULFATE (ALBUTEROL SULFATE HFA), OMEPRAZOLE, EPINEPHRINE and COLECALCIFEROL (VITAMIN D [COLECALCIFEROL]) for an unknown indication.    On 02-Aug-2021 at 1:45 PM, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 02-Aug-2021, the patient experienced THROAT IRRITATION (throat burning then traveled to chest), DYSPHONIA (voice changed from her throat closing up), HYPERTENSION (blood pressure was higher than usual.), DYSPNOEA (shotness of breath) and HEADACHE (5 min after the shot, severe sharp headache). 02-Aug-2021, the patient experienced CHEST PAIN (pain and pressure in her chest and throat), CHEST DISCOMFORT (pain and pressure in her chest and throat) and OROPHARYNGEAL PAIN (pain and pressure in her chest and throat). On 03-Aug-2021, the patient experienced CHEST DISCOMFORT (tightness and discomfort in chest). On 05-Aug-2021, the patient experienced FEELING ABNORMAL (has brain fog). On an unknown date, the patient experienced MEMORY IMPAIRMENT (memory issues) and LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (tired and could not perform my normal activities). The patient was treated with DIPHENHYDRAMINE HYDROCHLORIDE (BENADRYL [DIPHENHYDRAMINE HYDROCHLORIDE]) (intravenous) 03-Aug-2021 for Adverse event, at a dose of UNK UNK, q3h; PREDNISONE (oral) ongoing since an unknown date at a dose of 20 milligram twice a day; FAMOTIDINE ongoing from 03-Aug-2021 at a dose of 20 milligram and CETIRIZINE ongoing from 03-Aug-2021 at a dose of 10 milligram. On 08-Aug-2021, FEELING ABNORMAL (has brain fog) had resolved. At the time of the report, MEMORY IMPAIRMENT (memory issues), THROAT IRRITATION (throat burning then traveled to chest), CHEST PAIN (pain and pressure in her chest and throat), CHEST DISCOMFORT (pain and pressure in her chest and throat), OROPHARYNGEAL PAIN (pain and pressure in her chest and throat), CHEST DISCOMFORT (tightness and discomfort in chest), DYSPHONIA (voice changed from her throat closing up), HYPERTENSION (blood pressure was higher than usual.), LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (tired and could not perform my normal activities) and HEADACHE (5 min after the shot, severe sharp headache) had resolved and DYSPNOEA (shotness of breath) was resolving.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On 02-Aug-2021, Blood pressure measurement: 134/86 (High) 134/86. On 02-Aug-2021, Body temperature: 96.7 (normal) 97.6. On 02-Aug-2021, Heart rate: 92 (normal) 92 Beats per minutes. On 02-Aug-2021, Oxygen saturation: 99% 99% on R/A. On 02-Aug-2021, Respiratory rate: 99 (normal) 99 Beats per minutes. On 03-Aug-2021, Blood pressure measurement: 134/86 (High) 134/86. On 03-Aug-2021, Body temperature: 96.7 (normal) 96.7. On 03-Aug-2021, Heart rate: 83 (normal) 83 Beats per minutes. On 03-Aug-2021, Respiratory rate: 99 (normal) 99 Beats per minutes. On an unknown date, Blood pressure measurement: high (High) blood pressure was higher than usual..     The action taken with mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown) was unknown.    Takes medications for acid reflux and ulcerative.  Treatment medication included steroids and Pepcid.  Patient had epi pen at the appointment but did not use it.  Stopped on her way home from vaccine location to get Benadryl before things got worse and  continued to take two more doses that evening, a total of three doses The patient went to the ER on 03-Aug-2021 wasn't getter better, was there for 6 hours as outpatient  was given IV therapy. patient received antihistamine and steroid through IV on 2 AUG 2021.   Most recent FOLLOW-UP information incorporated above includes: On 13-Aug-2021: Significant Follow-up received and AE, Event outcome, Lab data, Concomitant medication, Historical Conditions, Allergies and treatment medications added.