Graves Disease; Thyroid was out of wack; Felt very ill; Down for the count; Fever (102.7 degrees F) for 5 days; Bad body aches; Bedridden; This is a spontaneous report from a contactable consumer. A 43-years-old female patient received bnt162b2 (PFIZER-BIONTECH COVID-19 VACCINE, Formulation: Solution for injection, Batch/Lot number was not reported) via an unspecified route of administration, administered in Arm Left on 20Apr2021 06:30 (age at vaccination 43-years-old) as DOSE 2, SINGLE for covid-19 immunisation. Medical history included ongoing Primary Ovarian Insufficiency Diagnosed 3-4 years ago and probably 4 at this point, hormone replacement therapy from an unknown date and unknown if ongoing. Concomitant medication included levonorgestrel (MIRENA); estradiol (ESTROGEN) taken for premature menopause, hormone replacement therapy. The patient previously took bnt162b2 (PFIZER-BIONTECH COVID-19 VACCINE, Formulation: Solution for injection, Batch/Lot number was not reported) via an unspecified route of administration, administered in Arm Left on 23Mar2021 as DOSE 1, SINGLE for covid-19 immunisation, flu vaccine and methimazole and experienced allergy. The patient experienced graves' disease, thyroid was out of whack on 15May2021, fever, bad body aches, bedridden, felt very ill, down for the count on 20Apr2021 16:30. Patient stated that she had read a study that 2 of 12 people receiving vaccination had Primary Ovarian Insufficiency (POI). She is interested in eventually receiving the Pfizer Covid 19 vaccine booster. She has had one provider recommend when she is eligible and another provider advising her not to get a booster. Her Graves' Disease has improved. She would like to know if there is any information on people developing these two disorders post vaccination and if they could experience a reoccurrence? Explained that she does not want her Graves' Disease to worsen. Consumer expressed dissatisfaction on no information in regards study on Pfizer Covid 19 vaccine associated Primary Ovarian Insufficiency. Consumer stated that, I appreciate all your time. I just want to the right thing for my body and for others. Caller states she does have a family history of thyroid issues, but she has never had a problem with her thyroid, it seems the vaccine kicked it in gear. Caller states that she is currently stable, but she still has no TSH but her other levels are back to normal. Caller states she is not sure if she should get the booster. Caller states one doctor said yes and the other was hesitant. Caller asking what Pfizer thinks and what information Pfizer has, she knows there have been a couple of cases of Graves that have popped up. Consumer stated that, she went on Lemon Balm which is a natural herb and she had major improvement with that. Caller states along with going gluten free and changing everything. Events occur at Bedtime that Evening. AE result in Physician Office. Patient has not taken any other Vaccinations prior to COVID-19 within four Weekes. The patient underwent lab tests and procedures which included blood test and result was everything was normal on Nov2020, she had a Blood test before the vaccine that past November, body temperature and result was 102.7 degrees Fahrenheit on 20Apr2021, full blood count down on 20Apr2021, thyroid function test and result was thyroid out of whack on 15May2021 She is currently stable, but she still has no TSH but her other levels are back to normal. Outcome of the event fever and felt ill was recovered on 24 Apr2021, Pain and bedridden was unknown and other events are recovering.  The lot number for the vaccine, [BNT162B2], was not provided and will be requested during follow-up.