Very large lymph node; This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP). The reporter is the patient.  A 59 year-old female patient received bnt162b2 (BNT162B2), administered in arm left, administration date 29Apr2021 12:45 (Lot number: EW0175, Expiration Date: 31Aug2021) at the age of 59 years as dose 2, single for covid-19 immunisation. Relevant medical history included: "Pulmonary embolism", start date: 11Mar2021, stop date: 12Mar2021, notes: Verbatim: Pulmonary embolism.; "Craniocerebral injury", start date: 29Jun2005 (unspecified if ongoing), notes: Verbatim: Traumatic brain injury; "Depression", start date: 2005 (ongoing), notes: Depression began about 15 years ago following her traumatic brain injury.; "Anxiety", start date: 2005 (ongoing), notes: Anxiety began about 15 years ago following her traumatic brain injury.; "Neuralgia" (ongoing), notes: Nerve pain from a previous brain injury that occurred before the traumatic brain injury in 2005.; "Seizure disorder", start date: 2005 (ongoing), notes: Seizure disorder began about 15 years ago following her traumatic brain injury; "Cholesterol" (unspecified if ongoing); "Sleep" (unspecified if ongoing); "Post traumatic stress" (unspecified if ongoing). Concomitant medication(s) included: XARELTO taken for pulmonary embolism, start date: Mar2021 (ongoing); CLONAZEPAM taken for sleep disorder, post-traumatic stress disorder (ongoing); DEPAKOTE taken for seizure (ongoing); CYMBALTA taken for depression, start date: 2005 (ongoing); NORTRIPTYLINE taken for neuralgia, start date: 2005 (ongoing); SIMVASTATIN taken for blood cholesterol (ongoing). Vaccination history included: Bnt162b2 (Dose: 1, Lot Number: ER8729 , Expiry Date: 31Jul2021 , Anatomical Location: Left arm), administration date: 08Apr2021, for Covid-19 immunization. The following information was reported: LYMPHADENOPATHY (non-serious) with onset May2021, outcome "recovered" (May2021), described as "Very large lymph node". The event "very large lymph node" was evaluated at the physician office visit.  Additional Information: The patient took Xarelto 15 mg twice daily x 21 days when she began and has since been taking 20 mg once daily. She has been taking clonazepam for years. She has been taking Depakote almost the whole time she has had the seizure disorder since 2005 following her traumatic brain injury. she was taking something else prior to Depakote. They switched her to Depakote because the medications she was originally on interferes with vitamin D uptake for women. She began taking simvastatin within the last 10 years. She went to urgent care because she told her physician about the size of her lymph node, her physician wanted to see her. Her lymph node was a 5 inch by 4 inch oval between her armpit and her breast. She noticed the enlarged lymph node within a day or two of receiving the Covid-19 vaccine, 30Apr2021 or 01May2021. Caller later reported that her lymph node grew to 5 inches by 4 inches within 48 hours of receiving the Covid-19 vaccine. She treated the swollen lymph node with heat, Tylenol, and sleep. The swollen lymph node started to go away in 5 days and was now gone. She was on blood thinners so she can only take Tylenol for pain relief. There were no additional vaccines administered on same date of the Pfizer suspect and prior vaccinations within 4 weeks.  No follow-up attempts are possible. No further information is expected.