anaphylaxis; The initial case was missing the following minimum criteria: ICH-Unspecified AE. Upon receipt of follow-up information on (10Oct2022), this case now contains all required information to be considered valid.  This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP) from medical information team, Program ID. The reporter is the patient.  A female patient received BNT162b2 (BNT162B2), as dose 3 (booster), single (Batch/Lot number: unknown) for covid-19 immunisation; varicella zoster vaccine rge (cho) (SHINGRIX), as unk unk, single (Batch/Lot number: unknown) for immunisation. The patient's relevant medical history included: "Latex Allergy" (unspecified if ongoing). Concomitant medication(s) included: FLU [INFLUENZA VACCINE] taken for immunisation as unk unk, single; PNEUMOCOCCAL VACCINE taken for immunisation as unk unk, single. Vaccination history included: Bnt162b2 (Dose: 2), for COVID-19 immunization, reaction(s): "anaphylaxis"; Bnt162b2 (Dose: 1), for Covid-19 Immunization, reaction(s): "anaphylaxis". The following information was reported: ANAPHYLACTIC REACTION (medically significant), outcome "unknown", described as "anaphylaxis". Therapeutic measures were taken as a result of anaphylactic reaction. Clinical course: Patient has had 1 primary series and 2 booster shots of COVID-19 Vaccine and wants to know if the 4th booster the liquid on the vial from Pfizer does not have latex on the vial because she has some immune issues and she took the Shingrix vaccine and experienced anaphylaxis and was on steroids. She wants to know if this is safe for her to take the 4th booster shot from Pfizer. She states this is a little complicated. This is the reason she has an immunologist. She had the flu shot and pneumonia vaccine and was fine and then the Shingrix she had instant anaphylaxis and Pharmacist said was too quick to be anaphylaxis. Ultimately, she was able to discern and very carefully and both Shingrix and the reconstituted vial had latex and liquid had latex in the vial. The FDA had warned her and that is the issue and prepared her. She is anything but antivaccine. Her immunologist came up with an allergy action plan. She called Pfizer and Moderna and the answer she got from both was that vial tops are latex base but liquid may or may not have latex in the liquid. The health department would not give her either vaccine. The pharmacist was willing to circumvent this. Her immunologist wrote her allergy action plan and started on steroids and on Pepcid. She would be with a senior pharmacist to take her blood pressure and do 30 minutes of observation and have her EpiPen. After doing successfully, she had a reaction but handled and able to do all 3. She was able to take 4th but this is different. She wants to make an inquiry. The latex top she knows but need to know if risk for having a reaction and shouldn't be taking steroids if not necessary and may compromise the vaccine and have the steroid does she take another dose of old one or wait for the new COVID-19 Vaccine. in order for her to break them apart. If in fact needed to this works so well to take with or without the flu shot as she knows some people are receiving the vaccines together. Her immunologist said to take separate.  Her experience has a latex allergy and getting an answer and avoid and should not have to take and is latex safe inside and out and be sad if forced to take steroids. She is already dealing with immune issues and why stress her body out. She trusts Pfizer. She needs an answer and leads her take to steroids that are not necessary. FDA trained her from prior events and doesn't want to have an event and at same time if can't get a clear answer shouldn't have to take. She is an ally. She just had a Latex Allergy awareness week and pressing to get vaccination and this is the issue. She has to work hand in hand. The patient has had the 3 original vaccines and booster, the new have not had the new one. Nobody would give that to her, health department and pharmacist would not give that to her because she had interpolation for vaccines, she had in succession with that together, had flu then pneumonia vaccine, then had the shingrix vaccine and the final step is having the covid vaccine. The patient had carefully tracked those vials, the vial of vaccine and the reconstituting vial, both were labelled latex safe. Upon further investigation, the liquid inside, part that was injected to her, had latex in it, immediately put her into anaphylaxis. She was type I, when got the inquiry got a response, yes, the caps are latex safe however cannot guarantee that the liquid inside or the reconstituting vial liquid may have a latex in it. Allergy reaction plan, take course of steroids, with antacid, take it before during and after, have an EpiPen. Told her if she would go fine with the first shot (covid vaccine) then she can go all three. She did have a reaction, but it is a very controlled reaction. She was able to have all three. She has a choice to take it, she was taking cetirizine and Pepcid. She should not take steroids unless necessary, because she has already immune issues. The patient didn't want to compound and make the vaccine less effective or omicron reaction worst by taking more steroids. The patient needs a very clear answer. She knew that the top of the vial is supposedly latex free but based on her experience with Shingrix vaccine, that was not the case. Hospital pharmacist has more serious immune issues than her do. Going to get her flu shot today, she hasn't started taking the course of steroid, cetirizine and Pepcid. The reaction patient has is not from the medicine it is from the latex." Pharmacist of a generic company, albuterol (can't remember the manufacturer) has latex in it, the colorant did have latex. Was sent to hospital. They accidentally gave her albuterol due to respiratory distress with covid and was treated at home and found out other products with latex on it and "zolpinex" is on it". Serious reported as no.  The information on the batch/lot number for BNT162b2 has been requested and will be submitted if and when received.