Withinn 24-48 hours of covid shot he started feeling itching again, basically on back, few spots here and there; This spontaneous case was reported by a patient and describes the occurrence of DERMATITIS ATOPIC (Withinn 24-48 hours of covid shot he started feeling itching again, basically on back, few spots here and there) in a 73-year-old male patient who received SPIKEVAX NOS (SPIKEVAX NOS) for COVID-19 prophylaxis.    Co-suspect product included non-company product DUPILUMAB (DUPIXENT) for Dermatitis atopic and Dermatitis allergic.    Patient was itching badly, rashes all over the body,.  The patient's past medical history included Pain in arm (Stabbing pain in arm) on 16-Apr-2019, Itching (Itching badly) on 16-Apr-2019, Conjunctivitis on 04-Jun-2019, Ocular discomfort (eye discomfort) on 04-Jun-2019 and Sleep deficit (Slept for 3 to 4hours and woken up by stabbing pain,). Concurrent medical conditions included Atopic dermatitis (On 11-SEP-2020, patient again developed rashes all over body and itching after injection of dupilumab.) and Dermatitis allergic. Concomitant products included BUPROPION HYDROCHLORIDE (WELLBUTRIN), LISINOPRIL, HYDROCHLOROTHIAZIDE and PRAVASTATIN for an unknown indication.   On 10-Apr-2019, the patient started DUPILUMAB (DUPIXENT) (Subcutaneous use) 600 milligram. On 17-Apr-2019, DUPILUMAB (DUPIXENT) (Subcutaneous use) dosage was changed to 300 milligram. On 24-Apr-2019, DUPILUMAB (DUPIXENT) (Subcutaneous use) dosage was changed to 300 milligram. On 10-Sep-2020, DUPILUMAB (DUPIXENT) (Subcutaneous use) dosage was changed to UNK, Hot at 60 degrees. On 10-Jan-2021, DUPILUMAB (DUPIXENT) (unknown route) dosage was changed to 1 dosage form. On 23-Feb-2021, the patient received dose of SPIKEVAX NOS (SPIKEVAX NOS) (unknown route) 1 dosage form. On 10-Mar-2021, DUPILUMAB (DUPIXENT) (unknown route) dosage was changed to at an unspecified dose. In February 2021, the patient experienced DERMATITIS ATOPIC (Withinn 24-48 hours of covid shot he started feeling itching again, basically on back, few spots here and there). At the time of the report, DERMATITIS ATOPIC (Withinn 24-48 hours of covid shot he started feeling itching again, basically on back, few spots here and there) outcome was unknown.        The action taken with SPIKEVAX NOS (SPIKEVAX NOS) (Unknown) was unknown.   For SPIKEVAX NOS (SPIKEVAX NOS) (Unknown), the reporter did not provide any causality assessments.   Patient had been taking all the concomitants all the way through 2 years with Dupilumab. Patient stated that within 24-48 hours after COVID shot, he started feeling itching again. He stated it was not as bad as it was before starting the Dupilumab, and he had not felt like this since starting Dupilumab. He stated it became obvious to him that it was something to do with COVID shot. The patient reported that it seemed like the vaccine interfered with Dupilumab efficacy. Patient stated that his last delivery was not at correct temperature. Since then, he's having flares. One was on his right leg that cleared but it did appear to be super itchy and red. The second flare happened after his last injection about a week ago. He had some flares on his back and buttocks. His wife applied some Eucresa, which had a burning sensation that dissipated. Treatment information was not reported.