PPROM at 36 wks, 4 days; Received vaccine at 20 weeks pregnant; This spontaneous prospective pregnancy case was reported by a consumer and describes the occurrence of PRETERM PREMATURE RUPTURE OF MEMBRANES (PPROM at 36 wks, 4 days) and MATERNAL EXPOSURE DURING PREGNANCY (Received vaccine at 20 weeks pregnant) in a 31-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch no. 037K20A) for COVID-19 vaccination.     The patient's past medical history included Polycystic ovary (Stable) in 2002, Alcohol use (0-1 drink per week) in 2007 and Artificial insemination on 02-Sep-2020. Family history included Cancer (Dad had ampullary cancer 6 or 7 years ago.). Concomitant products included METFORMIN for Polycystic ovarian syndrome, PRENATAL VITAMINS [ASCORBIC ACID;BETACAROTENE;CALCIUM SULFATE;COLECALCIFEROL;CYANOCOBALAMIN;FERROUS FUMARATE;FOLIC ACID;NICOTINAMIDE;PYRIDOXINE HYDROCHLORIDE;RETINOL ACETATE;RIBOFLAVIN;THIAMINE MONONITRATE;TOCOPHERYL ACETATE;ZINC OXIDE] and ASCORBIC ACID, BETACAROTENE, COPPER, NICOTINAMIDE, SELENIUM, TOCOPHEROL, XANTOFYL, ZINC (LUTEIN +) for an unknown indication.    On 30-Dec-2020 at 10:15 AM, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. The patient's last menstrual period was on 21-Aug-2020 and the estimated date of delivery was 28-May-2021. On 30-Dec-2020, the patient experienced MATERNAL EXPOSURE DURING PREGNANCY (Received vaccine at 20 weeks pregnant). On an unknown date, the patient experienced PRETERM PREMATURE RUPTURE OF MEMBRANES (PPROM at 36 wks, 4 days). The patient received mRNA-1273 (Moderna COVID-19 Vaccine) beginning around the  eighteenth week of the pregnancy. The delivery occurred  on 04-May-2021, which was reported as Premature. For neonate 1, the birth weight was 2500 grams (5lbs 8oz) with an APGAR score of 9 and 9 at (1, 5 minutes). The outcome was reported as Pre-Term Birth NOS. Weeks of gestation: 36 weeks 4 days; Gender: Male, Length: 50.8 cm, Head circumference: 31 cm. On 30-Dec-2020, MATERNAL EXPOSURE DURING PREGNANCY (Received vaccine at 20 weeks pregnant) had resolved. At the time of the report, PRETERM PREMATURE RUPTURE OF MEMBRANES (PPROM at 36 wks, 4 days) had resolved.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On 10-Mar-2020, Glucose tolerance test: normal (normal) Normal. On 16-Sep-2020, Pregnancy test: positive (Positive) Positive. On 15-Oct-2020, Ultrasound scan: normal (normal) Normal. On 16-Nov-2020, Ultrasound antenatal screen: normal (normal) Normal. In January 2021, Ultrasound foetal: normal (normal) 20 week anatomy scan. On 01-Oct-2021, Ultrasound scan: successful (Positive) Successful fertilization. On 19-Oct-2021, Ultrasound scan: normal (normal) Normal. On an unknown date, Amniocentesis: normal (normal) Normal. On an unknown date, Ultrasound foetal: normal (normal) At 13 weeks.     The action taken with mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) was unknown.   For mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular), the reporter did not provide any causality assessments.   Treatment information was not provided by reporter.   Most recent FOLLOW-UP information incorporated above includes: On 12-Apr-2021: NNI On 10-Jul-2021: Significant Follow up: Additional event and details regarding pregnancy were added.