elevation in his PSA level/PSA level had abruptly risen from 1.33 Dec2017 to 3.17 Jun2021 to 3.71 Jun2022; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP) from medical information team, Program ID.  A 77-year-old male patient received bnt162b2 (BNT162B2), on 07Apr2022 as dose 4 (booster) single (Lot number: FH8020) at the age of 76 years, in left arm for covid-19 immunisation. The patient's relevant medical history included: "low lipid levels" (unspecified if ongoing); "pretty low PSA" (unspecified if ongoing). There were no concomitant medications. Vaccination history included: bnt162b2 (DOSE 1, SINGLE, Batch/Lot: EK9231), administration date: 07Jan2021, for COVID-19 immunisation; bnt162b2 (DOSE 2, SINGLE, Batch/Lot: EL8982), administration date: 29Jan2021, for COVID-19 immunisation, reaction(s): "PSA level has abruptly risen from 1.33 Dec2017 to 3.17 Jun2021"; bnt162b2 (DOSE 3 (BOOSTER), SINGLE, Batch/Lot: EW0185), administration date: 01Oct2021, for COVID-19 immunisation. The following information was reported: PROSTATIC SPECIFIC ANTIGEN INCREASED (non-serious) with onset Jun2022, outcome "unknown", described as "elevation in his PSA level/PSA level had abruptly risen from 1.33 Dec2017 to 3.17 Jun2021 to 3.71 Jun2022". The event "elevation in his psa level/psa level had abruptly risen from 1.33 dec2017 to 3.17 jun2021 to 3.71 jun2022" required physician office visit. Relevant laboratory tests and procedures are available in the appropriate section.  Additional Information: Reporter's husband PSA level had abruptly risen from 1.33 Dec2017 to 3.17 Jun2021 to 3.71 Jun2022 to 5.99 Aug2023 to 4.93 Sep2023. It was not checked from Dec2017 to Jun2021 because of his age. This abrupt rise had concerned him. He had recently read articles on (withheld) about the possibility that the COVID vaccine could cause temporary spikes in PSA levels. Caller stated, patient noticed he had a history of pretty low PSA and it took a pretty big jump, a jump a year ago and bigger jump this year, he was trying to figure out what caused this, and stated it was possible to be having cancer causing this but the only thing that he had different was, he had 6 Pfizer covid shots, during the last few years, and his last two PSA levels he had were roughly two months after a Pfizer shot, and so he did some research, where he found on a you tube video, Privacy that had several patients with sudden spikes in PSA and recently had received covid vaccine.  Wasn't suggesting any connection between the pfizer shot or any other shot causing cancer, just a temporary spike in PSA, because it would go back to normal. It was just a temporary spike. Another video by (Name withheld), who was a jack pot took the same interview and cut parts of it off and put out something saying that the covid shots caused prostate cancer, and sterility, and so on and so on, the doctor did not say this in the interview and the doctor felt it was a temporary elevation in the PSA levels. He received his shots at the (withheld). Thought all were administered in his left arm. At his age the PSA numbers were not concerning but trends were. The big difference was in Jun2022 were his PSA level was 3.71 and then in Aug2023 his PSA level was 5.99. Last PSA was 4.93 in 12Sep2023, ran 2.5 miles a day. Had his PSA checked every year since he was 51 years old. had seen a urologist.; Sender's Comments: Linked Report(s) : US-PFIZER INC-202300302210 same patient/product, different dose (dose 2)/event;US-PFIZER INC-202300302451 same patient/product, different dose (dose 6)/event;