blood pressure was elevated; a migraine like headache; persistent severe headache; This is a spontaneous report from a contactable consumer (patient's wife). A 58-years-old male patient received BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE, Formulation: Solution for injection), via an unspecified route of administration on 20Apr2021 (Lot number and Expiry date was not reported) as 2nd dose, single dose for COVID-19 immunisation. Medical history included ongoing body mass index increased. The patient's concomitant medications were not reported. The patient received first dose of vaccine on an unspecified date for COVID-19 immunisation. History included he does not really take anything.  He has had some injuries lately but that is not a medical condition. On 20Apr2021 the patient experienced a migraine like headache, on an unspecified date the patient experienced blood pressure was elevated. He has had a persistent severe headache which sometimes feels like a migraine since receiving the vaccine. She was concerned because his MD has never heard of a headache lasting this long (approximately 3 weeks) after the vaccine. She wants to know if this has been reported before. The migraine like headache from what caller's husband said was it started in the evening. He had the vaccine in the morning, but caller was a little fuzzy on that because they did not go together. By evening, he had a dull headache that got worse. He has headache ever since. He went to the doctors a week ago and they checked his blood pressure and did all kinds of things. They did say they thought there was a chance it was the vaccine even thought they had not heard of it lasting that long. This week, yesterday, they took him to the ER to get an evaluation and it just will not stop. The family doctor did full blood workup and everything was in normal ranges. They took his sugar and protein that tells you hydration. His blood pressure was elevated. When he went to the ER, caller things they repeated the screenings. They did carbon monoxide testing, CAT Scan, and Chest x-ray. Everything came out good or, well, it was negative. They want him to see a neurologist. They hooked him up to an IV and they tried to relieve the pain with a headache cocktail and it did not take the edge off of it. So, they are a little baffled by that. Caller does not know specific dates, times, or results. Caller states she does not know what the medications were, maybe it was Toradol was one thing she heard, and they also gave him Benadryl with it. They said it was something they give to people with migraines and it takes it out and helps them sleep. He usually does not take anything but she got him to try allergy medicine, a couple days of Excedrin, and a couple of days of other things. None of them seem to work. He told the ER and they said if it does not work, do not take it. Also, he took Aleve a couple of days. Caller does not have any of this information as she is at work, and she states she did buy all of them. He tried name brand Aleve, Allegra for about 3 days, generic Excedrin which she thinks was Ibuprofen, and Tylenol. Caller confirms her husband was not admitted to the hospital, they sent him home with a referral to follow up with neuro and not the family doctor, and to come back if it gets worse. Today he was supposed to call them. Caller's husband was at the ER yesterday, 09May2021. A CAT Scan showed no mass or anything. They gave him several different things to relieve the headache and nothing worked. The outcome of the events was unknown.  Information on the lot/batch number has been requested.