Eye swelling (Moderate) - Right eyelid swelling; Mild hives; Itching; This is a spontaneous report received from contactable reporter(s) (Other HCP).  A 10 year-old male patient received bnt162b2 (BNT162B2), intramuscular, administered in deltoid left, administration date 22Nov2021 (Lot number: FL0007, Expiration Date: 24Jan2022) at the age of 10 years as dose 2, 0.2 ml single for covid-19 immunisation. Relevant medical history included: "EGG" (unspecified if ongoing); "LACTOSE" (unspecified if ongoing), notes: LACTOSE; "red meat" (unspecified if ongoing), notes: red meat; "artificial sugars" (unspecified if ongoing), notes: artificial sugars; "food colorant" (unspecified if ongoing), notes: food colorant; "Autistic disorder", start date: 22Aug2019 (unspecified if ongoing); "Attention deficit hyperactivity disorder", start date: 22Aug2019 (unspecified if ongoing); "Obstructive sleep apnoea of child", start date: 22Aug2019 (unspecified if ongoing); "Restless legs", start date: 22Aug2019 (unspecified if ongoing); "Epilepsy", start date: 22Aug2019 (unspecified if ongoing); "Severe persistent asthma", start date: 22Aug2019 (unspecified if ongoing); "Eczema", start date: 22Aug2019 (unspecified if ongoing); "Poor muscle tone", start date: 22Aug2019 (unspecified if ongoing); "Attention deficit hyperactivity disorder", start date: 22Aug2019 (unspecified if ongoing). Family history included: "Schizophrenia" (unspecified if ongoing). Concomitant medication(s) included: PREDNISOLONE, start date: 22Nov2021. Past drug history included: Albuterol sulfate, start date: 20Aug2021, for wheezing or shortness of breath, notes: albuterol sulfate HFA 90 mcg/actuation aerosol inhaler  Filled, 12. Puffs every 4 6hrs as needed for wheezing or shortness of breath; Benadryl allergy, start date: 21May2021, reaction(s): "Drug allergy", notes: Benadryl Allergy 12.5 mg/5 mL oral liquid Prescribed, Take 10 mL every day by oral route in the evening.; Iron, start date: 23May2021, notes: Chewable-Vit-C with Iron tablet TAKE, 1 tablet by mouth every day; Ibuprofen, start date: 06Feb2020, notes: Children's Ibuprofen 100 mg/5 ml. oral suspension filled, Take 10 mL every 8 hours by oral route as needed.; Diazepam, start date: 10Oct2019, notes: Diazepam 5 mg-7.5 mg-10 mg rectal kit, filled, Insert 7.5 mg as needed by rectal route.; Divalproex, start date: 21Oct2021, notes: divalproex 125 mg capsule, delayed release sprinkle Filled, Take 2 capsules by mouth at bedtime; Flovent hfa, start date: 21Oct2021, notes: Flovent HFA 110 mcg/actuation aerosol inhaler filled, TAKE 2 PUFFS BY MOUTH TWICE A DAY; Fluticasone propionate, start date: 22Jan2021, notes: fluticasone propionate 50 mcg factuation nasal spray, suspension Renewed, Use 1 spray in each nostril twice a day; Hydrocortisone, start date: 02Jan2020, notes: hydrocortisone 2.5% topical cream Filled, apply to affected areas BID for up to 2 weeks at a time; Montelukast, start date: 21Jul2021, notes: montelukast 10 mg tablet Filled, Take 1 tablet(s) every day by oral route.; Senna, start date: 14Jul2020, notes: senna 8.8 mg/5 mL oral syrup filled, TAKE 5 MLS BY MOUTH TWICE A DAY; Triamcinolone acetonide, start date: 22Aug2019, notes: triamcinolone acetonide 0.1 % topical ointment Filled, Apply 1 application(s) twice a day by topical route for 7 days.; Lithium carbonate, start date: 27Oct2021, notes: Lithium carbonate 150 mg capsule; Dyanavel xr, start date: 01Nov2021, notes: Dyanavel XR 2.5 mg/mL oral 24 hr extended-release suspension Take & milliliter by mouth daily. Vaccination history included: Influenza (Route- Intramuscular, Ro- Deltoid right, NDD- 19515081841, Lot- 3477H, Mfg-ID-withheld- Exp date-30Jun2022-Vis inactivate influenza vaccine 06Aug2021), administration date: 15Nov2021, when the patient was 10 years old; Influenza injectable (route- Intramuscular, Ro- Deltoid left, NDD- 70461032004, Lot- 279828, Mfg-Soqirus- Exp date-20Jun2021-Vis inactivate influenza vaccine 20Jun2021,), administration date: 05Oct2020, when the patient was 9 years old; Influenza injectable (route- Intramuscular, Ro- Deltoid right, NDD- 70461031904, Lot- 261214, Mfg- Seqirus- Exp date-30Aug2020-Vis inactivate influenza vaccine 15Aug2019), administration date: 10Oct2019, when the patient was 8 years old; Dtap (Diphtheria, tetanus, Pertussis), administration date: 12May2015, when the patient was 4 years old; Dtap (Diphtheria, tetanus, Pertussis), administration date: 09Oct2012, when the patient was 16 months old; Dtap (Diphtheria, tetanus, Pertussis), administration date: 13Dec2011, when the patient was 6 months old; Dtap (Diphtheria, tetanus, Pertussis), administration date: 11Oct2011, when the patient was 4 months old; Dtap (Diphtheria, tetanus, Pertussis), administration date: 09Aug2011, when the patient was 2 months old; Haemophilus influenzae type b, administration date: 09Oct2012, when the patient was 16 months old; Haemophilus influenzae type b, administration date: 13Dec2011, when the patient was 6 months old; Haemophilus influenzae type b, administration date: 11Oct2011, when the patient was 4 months old; Haemophilus influenzae type b, administration date: 09Aug2011, when the patient was 2 months old; Hepatitis a (Hep A, pad/adol,2 dose), administration date: 09Oct2011, when the patient was 16 months old; Hepatitis a (Hep A, pad/adol,2 dose), administration date: 23Apr2013, when the patient was 20 months old; Hepatitis b (Hep B, adolescent or pediatric), administration date: 09Jun2011; Hepatitis b (Hep B, adolescent or pediatric, 2m1do), administration date: 09Aug2011; Hepatitis b (Hep B, adolescent or pediatric, 6m5do), administration date: 13Dec2011; Mmr (1Yomo), administration date: 12Jun2012; Mmr (4Yomo), administration date: 12Jun2015; Pneumococcal (2modo), administration date: 08Aug2011; Pneumococcal (4m3do), administration date: 11Oct2011; Pneumococcal (6m5do), administration date: 13Dec2011; Pneumococcal (1Y4mo), administration date: 09Oct2012; Ipv (4m9do), administration date: 11Oct2011; Ipv (4Y5do), administration date: 12Dec2011; Ipv (4YoMo), administration date: 12Aug2015; Rotavirus (2m4do), administration date: 09Aug2011; Rotavirus (4m3do), administration date: 11Oct2011; Rotavirus (6m5do), administration date: 13Dec2011; Varicella (1Yomo), administration date: 12Jun2012; Varicella (4Yomo), administration date: 12Jun2015. The following information was reported: EYE SWELLING (non-serious) with onset Nov2021, outcome "recovered", described as "Eye swelling (Moderate) - Right eyelid swelling"; URTICARIA (non-serious) with onset Nov2021, outcome "recovered", described as "Mild hives"; PRURITUS (non-serious) with onset Nov2021, outcome "recovered", described as "Itching". The events "eye swelling (moderate) - right eyelid swelling", "mild hives" and "itching" were evaluated at the physician office visit. Relevant laboratory tests and procedures are available in the appropriate section. Therapeutic measures were taken as a result of eye swelling, urticaria, pruritus.  Additional Information: Not been involved with bullying. use seat belt or car seat routinely. No siblings or pets. Patient smoke and carbon monoxide detectors in home. No guns present in your home. Substance Use: None. Behavioural Health: prior behavioural or mental health treatments or interventions: (Notes: in PR used to have therapy, and medication for ADHD (Disnabel-B Mg)). No stressful or traumatic event. No History of Child Abuse, Sexual Abuse, Domestic Violence, Religious Community, Faith: Yes. born on C section, at 36 weeks he has asthma he had difficulties lifting his own body walked late, walked late (3 1/2 years potly trained within normal range he has enuresis but only at school he was diagnosed with nocturnal epilepsies (takes mediation Depakote). Surgical history not reviewed (Last reviewed 21Jul2021). Past Medical History not reviewed (last reviewed 21Jul2021). Child was administered the covid vaccine at approximately 1.30pm, at 1:50pm I was called to the room que lo allergic reaction, his R eyelid was swollen and red. He was speaking normally but c/o mild itching. no throat or tongue or lip swelling, was breathing well on zoom air, no-shots pain or other symptoms, no wheezing. child noted to have mild edema of the R eyelid very slight hives on the chest. OP patent, no edema, no lip swelling. speech is normal. able to swallow normally $1, s2. borderline tachycardia. CTAB, nl effort. breathing well on room air, no wheezing, no increased effort BS+ soft NTND. Assessment / Plan- . Allergic disposition - Child with an allergic reaction approx. 15-20 minutes s/p vaccine developing R eyelid swelling and hives. Given Benadryl and Pepcid with improvement in symptoms within 15 minutes. Vitals were stable without. Itching and hives resolved during his appointment. R eyelid swelling was reducing. prescribed a course of prednisolone x5 days. predisposing factors - severe asthma, eczema, hx of egg allergy. Does not have an EpiPen at home. reviewed reasons to call #. Avoid all food triggers today to avoid worsening allergic cascade. Child was stable and clinically improved prior to leaving the office. Allergy, unspecified, initial encounter. prednisolone 15 mg/5 mL oral solution - Take 20 mL every day by oral route for 5 days. Qty: 100 mL Refills: 0 Pharmacy: (Withheld)/withheld. Benadryl Allergy 12.5 mg/5 mL oral liquid - Take 10 mL every day by oral route in the evening. Quantity: 1 118 mL bottle(s). Pepcid 20 mg tablet- Take 1 tablet(s) by oral route. Quantity: 1 tablet(s)  Follow-up attempts are completed. No further information is expected.