Dupuytrens contracture; she developed three hard cysts in the palm of her right hand; injection site pain; her arm will start bothering her; her right arm is hurting where the injection site is; This is a spontaneous report received from a contactable consumer (patient) reported for herself. A 61-years-old female patient received second dose of BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE, Solution for injection, Lot number: EW0169, Expiration date: unknown) via an unspecified route of administration, administered in right arm on 23Apr2021 at 10:00 am (age at vaccination was 61 years) as dose 2, single for COVID-19 immunization. The patient did not have any medical history. Concomitant medications were not reported. The patient previously received first dose of BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE, Solution for injection, Lot number: EN6204, Expiration date: unknown) via an unspecified route of administration, administered in right arm on 26Mar2021 at 15:00 pm (age at vaccination was 61 years) as dose 1, single for COVID-19 immunization. The patient did not receive any other vaccinations within four weeks prior to the first administration date of the suspect vaccine. No additional vaccines were administered on same date of the Pfizer suspect. The patient was calling about the COVID 19 vaccine. She believed she had a side effect resulting from the COVID 19 vaccine about 3 weeks after she received the second dose. Three weeks after receiving the second dose of the Pfizer BioNTech COVID-19 vaccine, just overnight the patient developed three hard cysts in the palm of her right hand/three hard cysts in her right palm. The cysts showed up overnight. She went to two doctors, her primary care physician and her hand doctor and both diagnosed her with Dupuytrens contracture. She wanted to know if that was an immune response and if that diagnosis had been reported by others who received the Pfizer BioNTech COVID-19 vaccine. After receiving her second dose of the Pfizer BioNTech COVID-19 vaccine on 23Apr2021 caller has been experiencing injection site pain that comes and goes (on/off) and wanted to know if there was any information about the injection site hurting for as long as it has. She received the response which stated that how long side effects last (v3.0) in general, local side effects; the ones you get on the arm where you got the shot were mostly mild-to-moderate in severity and resolved within 1 to 2 days. Side effects after your second shot may be more intense than the ones you experienced after your first shot. and attached VR - section safety long how potential AE will last and referred to HCP, as Pfizer is unable to make treatment recommendations to individual patients. She wanted to add that randomly out of nowhere, in her right arm where she got the COVID 19 injection, right where the shot went in, was still bothering her. She would not even be thinking about the COVID 19 vaccine and her arm would start bothering her. Her arm was sore at the injection site the day after the vaccine but like right now while on the phone, her right arm was hurting where the injection site was. She thought that also began with the second COVID 19 vaccine. At her primary care doctor, she had an exam. At the hand doctor she had an exam and a hand x-ray. She asked whether that was an immune response to the COVID 19 vaccine and were other people experiencing that or heard of that. The event three hard cysts in the palm of her right hand/ three hard cysts in her right palm required a visit to Physician Office. The adverse events did not require a visit to Emergency Room. The outcome of the events was not resolved.  Follow-up attempts are completed. No further information is expected.  Follow-up (01Jul2021 and 06Jul2021): New information received from a contactable consumer (patient) reported for herself included: Updated the details of the events, details of first and second dose of vaccine, details of vaccine supplemental form and details of follow-up attempts.