pruritis/itching all over; she is still tingling around her shoulders and neck; This is a spontaneous report from a contactable consumer reported for herself. An 80-year-old female patient received bnt162b2 (PFIZER-BIONTECH COVID-19 mRNA VACCINE, Solution for injection Batch/Lot Number: EN6200) via an unspecified route of administration on 20Feb2021 13:30, as dose 1, single for COVID-19 immunization. Medical history included ongoing blood pressure, ongoing cholesterol, and ongoing acid reflux. Concomitant medications included algeldrate, alginic acid, magnesium trisilicate, sodium bicarbonate (GAVISCON [ALGELDRATE; ALGINIC ACID; MAGNESIUM TRISILICATE; SODIUM BICARBONATE]); esomeprazole magnesium (NEXIUM [ESOMEPRAZOLE MAGNESIUM]) taken as Antacid; vitamin d nos (VITAMIN D NOS); vitamin A; and blood pressure medicine (unspecified). On 20Feb2021 (Saturday), the patient got the first dose 20Feb2021 and the itching started after midnight. On 21Feb2021 at 02:00 AM, she experienced itching all-over, but it had diminished and was now on her shoulder and neck area. She noticed, it got worse after she has taken her reflux medication Nexium and Gaviscon and wanted to know the expected duration of this side effect. She mentioned that she had vaccine, Saturday at about 1:30 PM it was reported that it went fine but at about 2 AM she woke up itching and she didn't think anything about it and thought it would go way but continued and it gets worse when she takes her antacid. She quit taking her Nexium, it got worse with that antacid. It was a little better, but on an unspecified date in 2021, she was still tingling around her shoulders and neck and wanted to report it, but she also wanted to see how long she might have this problem or when would it go away finally. As her itching started after midnight and was fine until then which was why she thought it was something to do with her acid reflux medicine because she took it before she went to bed and then yesterday, she took Gaviscon, and the itching got worse. She says it was like Pepcid or something like that, it was an antacid. She also took her prescribed medication for acid reflux. It was improved but it was still there. Further she added that it was not like she itches and scratches all the time, but it was just there, mainly around shoulders and neck. She was startled she had any reaction because she did not right at first but might be people should know that you still could have a reaction. She took the Nexium that night before and she had taken all her medicines as well which was her blood pressure medicine, cholesterol medicine, Nexium, vitamin D and A vitamin. She had taken all of those the night she started itching. Last night all she took was her blood pressure medicine. She also had taken Tylenol and when she started itching like when it was bad, she took some, it was like allergy relief like Zyrtec (generic). Last night all she took was blood pressure medicine because she did not want to mess with anything. She had not taken any antacid since about 12 yesterday morning and the itching got worse than that was why she was thinking maybe that was the problem. Therapeutic measures were taken as a result of the events with Tylenol and Zyrtec. The outcome of the event pruritis/itching all over was resolving, while the outcome of the other event was unknown.   No follow-up attempts are possible, no further information is expected.