VISION PROBLEMS/ EYES WERE BLURRY; RED AND VERY IRRITATED EYES; PROBLEM WITH THROAT; PROBLEM WITH HEART; PROBLEM WITH LUNGS; PAIN UNDER RIBS; STOMACH PAIN; HANDS ARE SORE, SWOLLEN AND PAINFULL; SWOLLEN AND PAINFULL JOINTS; BOTHERED HER CHEST; LEG PAIN; RASH ON HANDS, ARMS, LEGS, FEET, CHEST / BAD, YELLOWISH, WHITISH RASH ON HAND; REALLY BAD FACE DISCOLORATION / SKIN TURNED YELLOW WITH BROWN SPOTS/ ARM DISCOLORED, LEAVING SPOTS ALL OVER IT; RED RASH UNDER NOSE; REVACCINATION WITH DIFFERENT COVID-19 VACCINE; This spontaneous report received from a patient concerned a 7 decade old female of an unspecified race. The patient's height, and weight were not reported. The patient's concurrent conditions included: human immunodeficiency virus infection (HIV positive). The patient received covid-19 vaccine ad26.cov2.s (dose number in series 1) (suspension for injection, route of admin not reported, batch number: 1802068 expiry: UNKNOWN) dose was not reported, 1 in total, administered on 07-MAR-2021 for covid-19 prophylaxis. Age at time of vaccination 60 years old. Concomitant medications included cobicistat/elvitegravir/emtricitabine/tenofovir alafenamide fumarate for HIV infection. On an unspecified date, the patient experienced bothered her chest (dose number in series 1). The patient additionally received Non-company suspect vaccine included: (Moderna Covid-19 Vaccine) (dose number in series 2) elasomeran (batch number: 019F21A expiry: UNKNOWN, form of admin and route of admin were not reported) dose was not reported, administered on 09-NOV-2021 for covid-19 prophylaxis which was associated with revaccination with different covid-19 vaccine (dose number in series 2). On 11-NOV-2021, the patient experienced red rash under nose and had really bad face discoloration (dose number in series 2). The patient additionally received Non-company suspect vaccine included: (Moderna Covid-19 Vaccine) (dose number in series 3) elasomeran (batch number: 058H21B expiry: unknown, form of admin and route of admin were not reported) dose was not reported, administered on 25-FEB-2022 for covid-19 prophylaxis. On 26-FEB-2022, the patient experienced rash on hands, arms, legs, feet, chest / bad, yellowish, whitish rash on hand (dose number in series 3). On an unspecified date, the patient experienced recurrence of skin discoloration (skin turned yellow with brown spots/ arm discolored, leaving spots all over it), problems with eyes, problem with throat, problem with heart, problem with lungs, pain under ribs, stomach pain, and leg pain (dose number in series 3). On an unspecified date, the patient hands look really bad, and they still do today. They are sore, swollen and painful, even in my joints (swollen and painfull joints). The patient was able to barely write. The patient visited physician office to discuss the rash present on face, arm, chest, hands, legs and feet. The patient arm and hand goes dead. The physician recommended CeraVe Lotion but it did not make the patient's condition any better.   On 20-APR-2022, the patient later went to check her eyes as she was having vision problems and eyes were blurry (vision problems/ eyes were blurry), red, and irritated-very irritated (red and very irritated eyes) (dose number in series 3). They said that something was wrong with her eyes. On 01-NOV-2021, Laboratory data included: Alanine aminotransferase 11, Aspartate aminotransferase 16, and Creatinine 0.74. On 16-NOV-2021, Laboratory data included: CD4 lymphocytes 208 (L). On 02-FEB-2022, Laboratory data included: Alanine aminotransferase 10, Aspartate aminotransferase 16, CD4 lymphocytes 210 (L), Creatinine 0.78, and GFR 82. On 28-MAR-2022, Laboratory data included: Endoscopy gastrointestinal stomach was yellow-the same color as it is all over body, esophagus was normal, localised moderate inflammation characterized by erosions was found in the gastric antrum, first portion of duodenum and second portion of duodenum were normal, gastritis, and Stomach biopsy antrum: moderate reactive gastropathy, fundus: normal, H. pylori: not identified.  The action taken with covid-19 vaccine ad26.cov2.s, elasomeran (dose number in series 2), and elasomeran (dose number in series 3) was not applicable. The patient recovered from bothered her chest, had not recovered from red rash under nose, really bad face discoloration / skin turned yellow with brown spots/ arm discolored, leaving spots all over it, rash on hands, arms, legs, feet, chest / bad, yellowish, whitish rash on hand, vision problems/ eyes were blurry, problem with throat, problem with heart, problem with lungs, pain under ribs, stomach pain, leg pain, red and very irritated eyes, hands are sore, swollen and painfull, and swollen and painfull joints, and the outcome of revaccination with different covid-19 vaccine was not reported. This report was non-serious.