pain, stiffness and joint swelling (hands and lower legs ); pain, stiffness and joint swelling; pain, stiffness and joint swelling; Worsened after second Covid vaccine; fatigue; pain at night and pain while resting; aggravating her arthritis; This is a spontaneous report received from contactable reporter(s) (Other HCP).  A 47 year-old female patient (not pregnant) received bnt162b2 (BNT162B2), intramuscular, administration date 29Aug2021 (Batch/Lot number: unknown) at the age of 47 years as dose 2,single for covid-19 immunisation. Relevant medical history included: "Bilateral Carpal Tunnel Syndrome" (unspecified if ongoing), notes: Note: Bilateral Carpal Tunnel Syndrome; "Hypertension" (unspecified if ongoing), notes: Note:Hypertension; "Obesity" (unspecified if ongoing), notes: Note: Obesity; "Recurrent Headache" (unspecified if ongoing), notes: Note: Recurrent Headache; "Obstractive Sleep Apnea" (unspecified if ongoing), notes: Note: Obstractive Sleep Apnea; "Chronic Pain of Multiple Joints" (unspecified if ongoing), notes: Note: Chronic pain of Multiple Joints; "Trigger Ring Finger of Right Hand" (unspecified if ongoing), notes: Note: Trigger Ring Finer of Right Hand. Concomitant medication(s) included: NEXPLANON; FLONASE [FLUTICASONE PROPIONATE]; PROPRANOLOL HYDROCHLORIDE; TORSEMIDE. Past drug history included: Erythromycin, reaction(s): "Allergy", notes: Note: Allergy. Vaccination history included: Bnt162b2 (Dose Number: 1, Batch/Lot No: Unknown. Not available/provided to reporter at the time of report completion, Route of Administration: Intramuscular), administration date: 08Aug2021, when the patient was 47 years old, for Covid-19 immunization. The following information was reported: ARTHRALGIA (non-serious) with onset 05Sep2021, outcome "not recovered", described as "pain, stiffness and joint swelling (hands and lower legs )"; JOINT STIFFNESS (non-serious), JOINT SWELLING (non-serious) all with onset 05Sep2021, outcome "not recovered" and all described as "pain, stiffness and joint swelling"; CONDITION AGGRAVATED (non-serious) with onset 05Sep2021, outcome "not recovered", described as "Worsened after second Covid vaccine"; FATIGUE (non-serious) with onset 05Sep2021, outcome "not recovered", described as "fatigue"; PAIN (non-serious) with onset 05Sep2021, outcome "not recovered", described as "pain at night and pain while resting"; ARTHRITIS (non-serious) with onset 05Sep2021, outcome "not recovered", described as "aggravating her arthritis". The events "pain, stiffness and joint swelling (hands and lower legs )", "pain, stiffness and joint swelling", "pain, stiffness and joint swelling", "worsened after second covid vaccine", "fatigue", "pain at night and pain while resting" and "aggravating her arthritis" were evaluated at the physician office visit. Therapeutic measures were taken as a result of arthralgia, joint stiffness, joint swelling, condition aggravated, fatigue, pain, arthritis.  Additional Information: No, other vaccine in four weeks. No, Covid prior vaccination. No, covid tested post vaccination. Patient complains of pain, stiffness and joint swelling (hands and lower legs ) Worsened after second Covid vaccine. Affected locations include the right knee, left knee, right wrist, left wrist, right foot, left foot, right MCP, left MCP, right ankle and left ankle. Associated symptoms include fatigue, pain at night and pain while resting. Pertinent negatives include no fever or rash. Treatments include NSAIDs and acetaminophen (Goody powders). The treatment provided no relief. Factors aggravating her arthritis include climbing stairs and gripping.  No follow-up attempts are possible; information about lot/batch number cannot be obtained. No further information is expected.