extreme fatigue; flu symptoms; not feeling well/ general malaise; chills; fever; Headache; really bad body aches; really bad body aches, specifically in his knees; his body was just inflaming; having trouble concentrating; brain fog; This is a spontaneous report from a contactable consumer (patient). A 65-year-old male patient received his second dose of BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE, lot number: EP6955), via an unspecified route of administration on 26Mar2021 at 16:30 (also reported as 17:00) at single dose for COVID-19 immunization and immunoglobulin g human (IGG), intravenous from an unspecified date at an unspecified dose and frequency for common variable immunodeficiency (CVID). Medical history included CVID in which he received treatment for this condition and also an infusion of IgG immunoglobulins. He has worked so hard not to get COVID. He happens to have CVID, so he was immunocompromised, that's why he was worried about getting COVID. He gets an intravenous infusion of IgG because his body doesn't make IGG antibodies, but it dissipates over two months and he gets it again. The patient was and is still an athlete. He has had a lot of sports injuries, osteoarthritis in both knees, and has had shots up in both knees. He has what's called extended cortisone in his knees. Concomitant medication included unspecified medication for CVID. The patient previously took flu shot and experienced sore arm. He also received the first dose of BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE, lot number: EN6198), via an unspecified route of administration on 05Mar2021 at single dose for COVID-19 immunization and experienced inflammation and pain in the wrists, very sore arm which was way more than a flu shot, and mild tiredness. On Mar2021, the patient reported that about 18-20 hours post second shot, he started to get flu symptoms, but he wouldn't say it was terrible. He was not feeling well, had chills, mild fever, slight headache, and general malaise. It was not terrible, he just laid low and subsequently, two days later, had really bad body aches, specifically in his knees. He has had a lot of sports injuries and osteoarthritis in both knees, but his knees prior to the shot were fine. He started to get really achy, his body was just inflaming and was going to where he has a deficit. He was now getting extreme fatigue, it's six, seven, eight days after the shot (Apr2021); he was feeling really tired. He also has trouble concentrating and he's feeling like he's getting brain fog and starting to get worse on 2021. His primary care physician (PCP) thought he's extra tired because of the IgG infusions and because of his immune system. He called his immunologist to see if they could speed up infusion times. They did not believe CVID was adding or exacerbating a bad reaction. They thought he was just having a strong reaction, because the vaccine was strong. He added that considering a bell curve, most people were tired for two to three days and he was at the end of the bell curve, where it lasts longer. The only reason for his call was he's at a dead end. They told him the good news was that maybe he's making strong antibodies. He had to take MRNA vaccine because people who have CVID don't make their own antibodies. He stated that his question was from Pfizer's data, if somebody aged 65, do Pfizer see people who have extreme fatigue for longer periods of time or longer times concentrating. He added that two days ago, it was really bad. He was nine days out and yesterday he's finally a little better. He didn't know how he was today. He has a headache and thick head and was asking if he could take ADVIL. He took two ADVIL and it helped, give him four, five, or six hours and it would wear off. He was worried about being on ADVIL all the time. The action taken in response to the events for immunoglobulin g human was unknown. The outcome of the event fatigue was recovering, not recovered for foggy feeling in head, and unknown for all other events.   Follow-up attempts are completed. No further information is expected.