Flu Like Symptoms after each dose; Really Sick after each dose; fever after each dose; hives/lower extremities (feet and legs)- worse/also occurred on torso which was second worse/also occurred on arms, hands, and palms-3rd worse; itching over most of the body/lower extremities (feet and legs)- worse/also occurred on torso which was second worse/also occurred on arms, hands, and palms-3rd worse; This spontaneous case was reported by a consumer and describes the occurrence of INFLUENZA LIKE ILLNESS (Flu Like Symptoms after each dose), ILLNESS (Really Sick after each dose), URTICARIA (hives/lower extremities (feet and legs)- worse/also occurred on torso which was second worse/also occurred on arms, hands, and palms-3rd worse), PRURITUS (itching over most of the body/lower extremities (feet and legs)- worse/also occurred on torso which was second worse/also occurred on arms, hands, and palms-3rd worse) and PYREXIA (fever after each dose) in a female patient of an unknown age who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch no. 039F21A) for COVID-19 vaccination.     No Medical History information was reported.    On 04-Nov-2021, the patient received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 15-Nov-2021, the patient experienced URTICARIA (hives/lower extremities (feet and legs)- worse/also occurred on torso which was second worse/also occurred on arms, hands, and palms-3rd worse) and PRURITUS (itching over most of the body/lower extremities (feet and legs)- worse/also occurred on torso which was second worse/also occurred on arms, hands, and palms-3rd worse). On an unknown date, the patient experienced INFLUENZA LIKE ILLNESS (Flu Like Symptoms after each dose), ILLNESS (Really Sick after each dose) and PYREXIA (fever after each dose). The patient was treated with PREDNISONE for Adverse event, at an unspecified dose and frequency and CETIRIZINE HYDROCHLORIDE (ZYRTEC [CETIRIZINE HYDROCHLORIDE]) for Adverse event, at a dose of triple dose. On 07-Dec-2021, URTICARIA (hives/lower extremities (feet and legs)- worse/also occurred on torso which was second worse/also occurred on arms, hands, and palms-3rd worse) and PRURITUS (itching over most of the body/lower extremities (feet and legs)- worse/also occurred on torso which was second worse/also occurred on arms, hands, and palms-3rd worse) had resolved. At the time of the report, INFLUENZA LIKE ILLNESS (Flu Like Symptoms after each dose), ILLNESS (Really Sick after each dose) and PYREXIA (fever after each dose) outcome was unknown.            Concomitant medication was not provided. The patient had terrible hives and itching over most of the body, except for face. The reaction was centered to lower extremities (legs and feet) where it was the worse. The hives and itching also occurred on torso which was second worse. The hives and itching also occurred on arms, hands, and palms which was the least intensity. It would come and go, worse at times and had no rhyme or rhythm to it. The patient was taking prednisone, but it did not help. She was advised to take triple dose of Zyretc by her dermatologist. After taking the Zyrtec the AEs stopped on 07-Dec-2021. The onset date was 15-Nov-2021.   This case was linked to MOD-2021-406820, MOD-2021-406828 (Patient Link).