This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP), from medical information team. The reporter is the patient. A 70-year-old female patient received bnt162b2 (BNT162B2), administered in arm right, administration date 04Mar2021 09:00 (Lot number: EN6198) at the age of 70 years as dose 1, 0.3 ml single and administration date 25Mar2021 09:00 (Lot number: EN6207) as dose 2, 0.3 ml single for covid-19 immunisation. The patient's relevant medical history and concomitant medications were not reported. The following information was reported: HEADACHE (non-serious) with onset 25Mar2021, outcome "not recovered", described as "excruciating headache Caller states it lasted for four days, she thought her head was going to explode."; PAIN (non-serious) with onset Mar2021, outcome "unknown", described as "Her head just hurts so bad. Caller states it hurts around the crown, to the right of her crown"; HEADACHE (non-serious) with onset 04Mar2021, outcome "recovered" (Mar2021), described as "slight headache: first dose/ it hurts around the crown, to the right of her crown, in the lower right and upper left ". Therapeutic measures were taken as a result of headache. Additional information:  It was reported that the caller was a 70-year-old female who received both doses of the Pfizer Covid 19 vaccine. 04Mar- dose one- headache for 1-2 days: "Didn't amount to much." 25Mar- dose two- excruciating headache for 4 days strait.  "I thought my head was going to explode."  Nothing she took helped. Fifth day it let up some. She still has a headache now. "At night I can't sleep on a pillow because it hurts too much. I can't stand for anything to touch my head. Before the vaccine I rarely had a headache. Is there anything I can do?  What can I do?" Caller reports she was taking Extra strength Tylenol 500mg x2 an hour before breakfast or when the headache was getting pretty bad. She can't take ibuprofen "because of her heart." "Have there been other people reporting this outside of the trial. She didn't think it would last this long- 6 weeks.  How long can side effects last. Caller states she got the second Pfizer vaccine on 25Mar2021, and it was 6 weeks ago today and for four days straight, even in the waiting room, she had an excruciating headache. Caller states it lasted for four days; she thought her head was going to explode. Caller states she took Tylenol and that didn't really help and then by Monday, it kind of calmed down but she had a headache every day for six weeks. Caller states she would take like two extra strength Tylenol an hour before breakfast, during the day, and one at night if need be. Caller states she's been taking the same heart medicine and everything else, she hasn't taken anything new. Caller states she can't sleep with her head on any pillows except a neck pillow because she puts her face on the neck pillow because her head just hurts so bad when she does that. Caller states and then she went to a chiropractor, and he did help some in her neck but she's still having headaches every day. Caller states it hurts around the crown, to the right of her crown, in the lower right and upper left. Caller states before she had the vaccine, she very rarely had a headache unless she hit her head, but she hasn't been able to wear anything tight around her head for years without getting a headache. Caller states she checked her medicine and nothing she takes causes headaches. Caller states she talked to her primary care doctor on Friday and her doctor said sometimes it takes people longer to get over side effects. excruciating headache: second dose: Caller states her headache started right after the second shot. Caller states hers started right after the second vaccine on 25Mar2021, she even had one while in the waiting room. Caller states for four days, it was an excruciating headache. Caller states it calmed down some but hasn't improved much. Caller confirms it is persisting. slight headache: first dose: Caller states she had a slight headache after the first vaccine. Caller states her headache after her first shot began 04Mar2021 and might have lasted a day or two at the most, but it wasn't a real bad headache like she experienced with the second dose. Caller states she had flu vaccines in her arm that might hurt, but she doesn't think she had any other reaction, that's what surprised her. but caller states she placed a call on Friday with her primary care doctor and she mentioned it to the doctor and the doctor said some people it takes longer to get over the side effects, just wait and if the caller still had headaches in a few weeks to just let the doctor know. No prior vaccinations within 4 weeks; List of any other vaccinations within four weeks prior to the first administration date of the suspect vaccine reported as no. The events did not cause emergency Room visit and Physician Office. Description of Product Complaint includes : Description of complaint: Caller reporting AE of headaches after first Pfizer Covid vaccine and second Pfizer Covid vaccine. Caller states the headaches after the second dose were much worse than the first. Caller states she took Tylenol and that didn't really help and then by Monday, it kind of calmed down but she has had a headache every day for six weeks. Product strength and count size dispensed: Quantity in bottle: 24 caplets; Dosage: Caller states they are 500mg caplets, extra strength Tylenol. TYLENOL: Caller states they are 500mg caplets, extra strength Tylenol (LOT Number: AAA123; Expiry Date: Dec2024; NDC: 50580-449-35; Quantity: 24 caplets). No follow-up attempts are needed. No further information is expected.