The last 2 doses were Moderna and she claims that she was symptom free for at least 6 weeks after getting the doses; This spontaneous case was reported by a patient and describes the occurrence of THERAPEUTIC RESPONSE UNEXPECTED (The last 2 doses were Moderna and she claims that she was symptom free for at least 6 weeks after getting the doses) in a 69-year-old female patient who received mRNA-1273 BIVALENT .222 (MODERNA COVID-19 VACCINE, BIVALENT (ORIGINAL AND OMICRON BA.4/BA.5)) (batch no. AS7164B) for COVID-19 prophylaxis.     The patient's past medical history included COVID-19 in March 2020. Previously administered products included for Product used for unknown indication: PFIZER BIONTECH COVID-19 VACCINE (First Dose, EN6203) on 05-Mar-2021, PFIZER BIONTECH COVID-19 VACCINE (Second Dose,  ER2613) on 26-Mar-2021, PFIZER BIONTECH COVID-19 VACCINE (Third Dose, FF8814, First Booster) on 15-Oct-2021 and Senior flu vaccine (Aug/Sep2022). Past adverse reactions to the above products included No adverse effect with PFIZER BIONTECH COVID-19 VACCINE, PFIZER BIONTECH COVID-19 VACCINE, PFIZER BIONTECH COVID-19 VACCINE and Senior flu vaccine. Concurrent medical conditions included Asthma (She is on Symbicort which keeps her lungs under good condition), Allergy (Allergies), Arthritis, Hypertension (Her BP is fairly under control) and Depression (Treated for depression which is working very well). Concomitant products included BUDESONIDE, FORMOTEROL FUMARATE (SYMBICORT) for Asthma.    On 19-Oct-2022, the patient received fifth dose of mRNA-1273 BIVALENT .222 (MODERNA COVID-19 VACCINE, BIVALENT (ORIGINAL AND OMICRON BA.4/BA.5)) (unknown route) 1 dosage form. On an unknown date, the patient experienced THERAPEUTIC RESPONSE UNEXPECTED (The last 2 doses were Moderna and she claims that she was symptom free for at least 6 weeks after getting the doses). At the time of the report, THERAPEUTIC RESPONSE UNEXPECTED (The last 2 doses were Moderna and she claims that she was symptom free for at least 6 weeks after getting the doses) outcome was unknown.        For mRNA-1273 BIVALENT .222 (MODERNA COVID-19 VACCINE, BIVALENT (ORIGINAL AND OMICRON BA.4/BA.5)) (Unknown), the reporter did not provide any causality assessments.   Patient received fourth dose of Moderna on 22-APR-2022, with batch no being reported as 001M21A. Patient stated that she contracted Covid-19 in Mar2020 before she received the 1st dose of the Covid-19 vaccine which led to her having long Covid. The symptoms she mentions were fever and fatigue. She had been pretty much sick for 13 months and stated that she will be pretty lucky if she was 4 days symptom free but symptoms mentioned come back. The symptoms appeared when she was under a lot of stress like at the time of the call where she had now been taking Dayquil for 3-4 days. She was losing a lot of time at work. The 1st 3 doses were Pfizer and she claimed that she did not get relief of her long Covid symptoms after the shots. The last 2 doses were Moderna and she claims that she was symptom free for at least 6 weeks after getting the doses. Treatment information was not reported.   Most recent FOLLOW-UP information incorporated above includes: On 14-Jun-2023: Live follow-up received and had no new information. On 14-Jun-2023: Follow-up received and added new event of unexpected therapeutic benefit and updated narrative.