It felt like her leg was a sleep and her left leg felt numb; It was twitching and pulsating and it was predominantly in her left leg but she did notice it a bit in her right leg; It was twitching and pulsating and it was predominantly in her left leg but she did notice it a bit in her right leg/ she was having a weird sensation in her legs; was to the point where she literally felt like she couldn''t do any exercising and was exhausted; She literally felt like she couldn''t do any exercising and was exhausted; it was like she would sit down or lay down and her leg would be tingling, it was more so the left leg that was tingly; She was extremely fatigued; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP). The reporter is the patient.  A 63 year-old female patient received bnt162b2 (BNT162B2), administered in arm left, administration date 17Sep2021 (Lot number: FA7485) at the age of 63 years as dose 2, single for covid-19 immunisation. Relevant medical history included: "Anxiety" (unspecified if ongoing), notes: she is crazy because she is anxious; "problems with varicose veins" (unspecified if ongoing). Concomitant medication(s) included: VITAMIN C [ASCORBIC ACID]; VITAMIN D [COLECALCIFEROL]; ZINC; QUERCETIN; ASPIRIN [ACETYLSALICYLIC ACID]. Vaccination history included: Bnt162b2 (DOSE 1, SINGLE LOT: FA6780), administration date: 27Aug2021, when the patient was 63 years old, for COVID-19 Immunization; Shingles vaccine, reaction(s): "didn't feel great". The following information was reported: HYPOAESTHESIA (non-serious) with onset 18Sep2021, outcome "not recovered", described as "It felt like her leg was a sleep and her left leg felt numb"; MUSCLE TWITCHING (non-serious) with onset 18Sep2021, outcome "not recovered", described as "It was twitching and pulsating and it was predominantly in her left leg but she did notice it a bit in her right leg"; LIMB DISCOMFORT (non-serious) with onset 18Sep2021, outcome "not recovered", described as "It was twitching and pulsating and it was predominantly in her left leg but she did notice it a bit in her right leg/ she was having a weird sensation in her legs"; LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (non-serious) with onset 18Sep2021, outcome "not recovered", described as "was to the point where she literally felt like she couldn''t do any exercising and was exhausted"; FATIGUE (non-serious) with onset 18Sep2021, outcome "not recovered", described as "She literally felt like she couldn''t do any exercising and was exhausted"; PARAESTHESIA (non-serious) with onset 18Sep2021, outcome "not recovered", described as "it was like she would sit down or lay down and her leg would be tingling, it was more so the left leg that was tingly"; FATIGUE (non-serious) with onset 18Sep2021, outcome "not recovered", described as "She was extremely fatigued". The events "it was twitching and pulsating and it was predominantly in her left leg but she did notice it a bit in her right leg" and "it was twitching and pulsating and it was predominantly in her left leg but she did notice it a bit in her right leg/ she was having a weird sensation in her legs" were evaluated at the physician office visit. Relevant laboratory tests and procedures are available in the appropriate section. Therapeutic measures were taken as a result of hypoaesthesia, muscle twitching, limb discomfort, loss of personal independence in daily activities, fatigue, paraesthesia.  No follow-up attempts are possible. No further information is expected.  Additional information: Reporter stated patient was getting either the Comirnaty or the Pfizer BioNTech Covid-19 vaccine. patient got the vaccine at the medical center in her hometown. Patient tried to take some supplements, like natural kind of supplements that she felt like was possibly helping. Patient was not overweight, that she was a vegetarian and a healthy person, patient thought she did not have a lot of health issues. she was taking the Quercetin because it was like a natural form of Hydroxychloroquine. Quercetin was helping for the pulsating and the twitching. She was not a hypochondriac and very rarely goes to the doctor. She did not take medication and seriously, until Covid hit, she had hardly taken anything, except Aspirin. She did not like medication very much. She had a D-dimer done and and it was a high level, but the doctor told her not to worry about it. Clarified that the D-dimer with the high level was done somewhere in Sep2021. She stated that they recommended getting it and she stated that she thought it was before the second vaccine but then stated that it was after but thought it was sometime around the vaccine, in that period of mid to late Sep2021. She had her B12 tested and started giving her B12 shots. Patient thought the B12 shots would help but they had not changed the tingling. Event pulsating and twitching in leg required physician office visit. Patient did not have any prior vaccinations (within 4 weeks). Patient did not have AE(s) following prior vaccinations.