fluid in knee and leg; fever was 101; body aches; fatigue; lymphedema; she had an "inflammation process" where her asthma and arthritis were aggravated.; she had an "inflammation process" where her asthma and arthritis were aggravated.; she had an "inflammation process" where her asthma and arthritis were aggravated.; the exacerbated arthritis and retention of fluid in the area; This is a spontaneous report from a contactable consumer (Patient). A 59-year-old female patient received BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE, Solution for injection, Lot Number: EW0151), via an unspecified route of administration, administered in left upper arm on 04Apr2021 10:15 AM (at the age of 59-year-old) as dose 2, single for COVID-19 immunisation. The patient's medical history included asthma with a family history, osteoporosis, Hashimoto's disease and MGUS (Monoclonal gammopathy of undetermined significance). The patient previously received BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE, Solution for injection, Lot Number: EN6206), via an unspecified route of administration, administered in right arm on 14Mar2021 (at the age of 59-year-old), as single dose for COVID-19 immunisation. Concomitant medications included salbutamol (PROVENTIL [SALBUTAMOL]); fluticasone propionate, salmeterol xinafoate (ADVAIR) 250/50, 1-2 times a day for all taken for unspecified indication, start and stop dates were not reported. On 07Apr2021, 2 days 13 hours 45 minutes after second dose of vaccine, the patient's fever was 101, with body aches and fatigue started in the early morning and lasted about 1.5 day and went away. On an unspecified date in 2021, 4 weeks after the second dose of vaccine or within a month she had an inflammation process where her asthma and arthritis were aggravated. That is when it was seen, felt, and observed by the patient. It took time for the patient's body to have a reaction to that. The inflammation process was persisting and worsened. she didn't have before that exacerbated her asthma and arthritis and she was almost certain it was from the vaccine. She stated that the exacerbated arthritis and retention of fluid in the area was continuing. she reported that she never had such a weird array of symptoms prior to getting the vaccine. The patient developed lymphedema on an unspecified date in 2021, out of nowhere because of the inflammation. There was no history of previous immunization with the Pfizer vaccine considered as suspect and no additional vaccines administered on same date of the Pfizer suspect. Patient did not receive any prior vaccinations within 4 weeks and did not experience any adverse event following prior vaccinations. On 26Apr2021 the caller visited the emergency room and did a leg doppler and never admitted as a patient. Patient visited emergency room and physician office and seen several doctors. The patient underwent lab tests and procedures which included body temperature: 101, on an unspecified date in 2021; cardiac stress test: fine, on an unspecified date in 2021; magnetic resonance imaging of right leg: extreme inflammation and fluid in knee and leg, on 14May2021 and magnetic resonance imaging of left leg: extreme inflammation and fluid in knee and leg, on 07Sep2021. The clinical outcome of events inflammation process was not resolved. The clinical outcome events fever, body aches and fatigue was resolved on unspecified dates in Apr2021 and outcome of all other events was unknown.   Follow-up attempts are completed. No further information is expected.