Post Vaccination=Nasal Swab/Covid Test Result=Positive; Post Vaccination=Nasal Swab/Covid Test Result=Positive; autoimmune disease/ Grave disease; My left eye is getting bigger; heart palpitations; shortness of breath; on her period. Since then I never stopped bleeding (abnormal vaginal bleeding); My head and brain constant hurts; blurred vision; eye pain; weight loss; severe hair loss; extremely fatigue; muscle and joints pain; muscle and joints pain; no energy at all; I'm getting frustrated My health is getting worse day by day.; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP). The reporter is the patient.  A 39 year-old female patient (not pregnant) received bnt162b2 (BNT162B2), administration date 27May2021 (Lot number: EWO177) at the age of 39 years as dose 1, single for covid-19 immunisation. The patient's relevant medical history was not reported. There were no concomitant medications. Past drug history included: Fluconazole, reaction(s): "allergies Fluconazole". The following information was reported: DRUG INEFFECTIVE (medically significant), COVID-19 (medically significant), outcome "unknown" and all described as "Post Vaccination=Nasal Swab/Covid Test Result=Positive"; BASEDOW'S DISEASE (medically significant) with onset 27May2021, outcome "not recovered", described as "autoimmune disease/ Grave disease"; EXOPHTHALMOS (medically significant) with onset 27May2021, outcome "not recovered", described as "My left eye is getting bigger"; PALPITATIONS (non-serious) with onset 27May2021, outcome "not recovered", described as "heart palpitations"; DYSPNOEA (non-serious) with onset 27May2021, outcome "not recovered", described as "shortness of breath"; HEAVY MENSTRUAL BLEEDING (non-serious) with onset 27May2021, outcome "not recovered", described as "on her period. Since then I never stopped bleeding (abnormal vaginal bleeding)"; HEADACHE (non-serious) with onset 27May2021, outcome "not recovered", described as "My head and brain constant hurts"; VISION BLURRED (non-serious) with onset 27May2021, outcome "not recovered", described as "blurred vision"; EYE PAIN (non-serious) with onset 27May2021, outcome "not recovered", described as "eye pain"; WEIGHT DECREASED (non-serious) with onset 27May2021, outcome "not recovered", described as "weight loss"; ALOPECIA (non-serious) with onset 27May2021, outcome "not recovered", described as "severe hair loss"; FATIGUE (non-serious) with onset 27May2021, outcome "not recovered", described as "extremely fatigue"; MYALGIA (non-serious), ARTHRALGIA (non-serious) all with onset 27May2021, outcome "not recovered" and all described as "muscle and joints pain"; ASTHENIA (non-serious) with onset 27May2021, outcome "not recovered", described as "no energy at all"; FRUSTRATION TOLERANCE DECREASED (non-serious) with onset 27May2021, outcome "not recovered", described as "I'm getting frustrated My health is getting worse day by day.". The events "autoimmune disease/ grave disease", "my left eye is getting bigger", "heart palpitations", "shortness of breath", "on her period. since then i never stopped bleeding (abnormal vaginal bleeding)", "my head and brain constant hurts", "blurred vision", "eye pain", "weight loss", "severe hair loss", "extremely fatigue", "muscle and joints pain", "muscle and joints pain", "no energy at all" and "i'm getting frustrated my health is getting worse day by day." were evaluated at the physician office visit and emergency room visit. Clinical course: Patient got the Pfizer first dose on 27May2021. Same day, she started having heart palpitations, shortness of breath. She have been to cardiologist. Now, she had developed heart palpitations, shortness of breath and several times, she had been to ER for that. When she took the vaccine, she was on her period. Since then, she never stopped bleeding (abnormal vaginal bleeding). She never had period issues before or any kind of underlying condition. She was always a very healthy person. Now, she developed autoimmune disease/Graves' Disease. Her left eye was getting bigger, her head and brain constant hurts, have extreme blurred vision, eye pain, weight loss, severe hair loss, extremely fatigue, muscle and joints pain no energy at all. It has been more than 8 months that she was suffering like this. Every other day she was going to see several doctors: Neuroophthalmologist, Cardiologist, Hematologist, Rheumatologist etc and doing several MRI, CT Scan, and blood work, X-Rays. She was getting frustrated that her health was getting worse day by day. Additional information: No other vaccine in four weeks and no other medications in two weeks. COVID was tested post-vaccination via Nasal Swab with result positive. The patient underwent the following laboratory tests and procedures: Blood Work: unknown results; CT Scan: unknown results; MRI: unknown results; Covid 19: positive, notes: Nasal Swab, post vaccination; X-Rays: unknown results.