left side pleural effusion; This is a spontaneous report from a contactable consumer (patient). A 75-year-old male patient received bnt162b2 (BNT162B2), dose 2 via an unspecified route of administration, administered in Arm Right on 05Feb2021 afternoon (Batch/Lot Number: EN5318) as DOSE 2, SINGLE for covid-19 immunisation. The patient medical history and concomitant medications were none. No prior vaccinations (within 4 weeks). It was added that prior vaccinations: None. No Prior, states he had the Shingles Vaccine and Flu Vaccine and he did fine. No additional vaccines administered on same date. The patient previously received BNT162B2 (lot: EL1283) dose 1 via administered at Right Arm received on 12Jan2021 for COVID-19 immunization. The patient stated that he had his first shot on 12Jan2021, and on 22Jan2021, after taking the shot, for several days or a week or so he had trouble breathing or getting enough oxygen. The patient went to the ER, and he was diagnosed with Bilateral Pleural Effusions, which is something he has never had before. The patient added they drained a liter and a half of fluid out of his chest cavity. It was confirmed that he was treated in the ER and released. It was reported that the patient is calling about the Covid 19 Vaccine. The patient stated he wanted to report some side effects that he doesn't know if they are from the Pfizer but they seem to be and he wanted to get them in the record. The patient stated we've got the 3rd shot in the near future, and if he gets the same symptoms again, he wanted it to be on the record. On 05Feb2021, he had his second dose. On 24Feb2021, the patient had another x-ray and it showed he had a left side pleural effusion. On 15Mar2021, he had a little over a liter drained out. The patient added on 29Apr2021, he had another drain of fluid done and they put a drain in his side, so that they could drain at home every so often. It was also reported that in Jun2021, the pleural effusion stopped on its own, which they said could happen but it was not likely. The patient stated that he was treated by the Clinic, and they couldn't figure out what it was. The caller states they did all sorts of tests. The patient states it could have been CHF, infection, cancer or other causes, but those were all ruled out. Eventually they took a biopsy of his chest lining and they ruled out cancer. For the treatment it was noted: Draining Fluid, Several CT scans, x-rays, and tests of all different kinds, the whole procedure took about 6 months. The patient states he lives about 4 hours from the hospital and they did a lot of examining trying to figure out what is was, but they never figured it out. It was added being it was after his first dose and again after the second dose, they figured it was the vaccine. The patient added if there is a booster shot and he gets the same problem he would be 99% sure that the vaccine is what caused it (the pleural effusions and fluid). The patient added that it takes a while for the fluid to build up; caller states probably 3-4 days later, he was having trouble walking back and forth in house with his breathing. The events require a visit to: Emergency Room? Yes, No Admission to hospital. The patient stated they wanted him to stay overnight but they figured it would be best not to; and physician office. The outcome of the event was recovered in Jun2021.; Sender's Comments: Linked Report(s) : US-PFIZER INC-202100999995 same patient/SD, different AE/dose number