The bumps on her toes may be arthritis; pain feels like her bone is hurting; pain in her vein on her leg; felt like a little ball on her toes and a little inflamed on the other; rash on lower back; swelling to injection site/pain and swelling where she got the shot; pain to lower leg/The pain in the leg/it was hurting; had some redness in the bottom of her back close to her waist on the left side; itchy; pain and swelling where she got the shot; My right leg was very swollen; caller's veins are thick and inflated; This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP) from medical information team. The reporter is the patient.  A 72 year-old female patient received bnt162b2 (BNT162B2), administered in arm left, administration date 23Sep2021 (Lot number: FE0809) at the age of 72 years as dose 1, single for covid-19 immunisation. Relevant medical history included: "Diverticulitis" (unspecified if ongoing); "Acid reflux (esophageal)" (unspecified if ongoing); "Sleep apnea" (unspecified if ongoing); "Pre-diabetes" (unspecified if ongoing); "Arthritis" (unspecified if ongoing); "bad veins" (unspecified if ongoing), notes: I have bad veins, and it runs in my family; "cholesterol " (unspecified if ongoing). Concomitant medication(s) included: ZINC; VITAMIN C [ASCORBIC ACID]; VITAMIN D [COLECALCIFEROL]. Vaccination history included: Flu (The flu vaccine many years ago, her face swelled up and she got sick but not the flu. The caller also got really sick from a vaccine when she was a kid but doesn't know which one it is.), for Immunization, reaction(s): "Sick", "face swelled up". The following information was reported: PERIPHERAL SWELLING (non-serious) with onset Sep2021, outcome "recovered", described as "My right leg was very swollen"; VEIN DISORDER (non-serious) with onset 2021, outcome "unknown", described as "caller's veins are thick and inflated"; ARTHRITIS (non-serious), outcome "unknown", described as "The bumps on her toes may be arthritis"; BONE PAIN (non-serious), outcome "unknown", described as "pain feels like her bone is hurting"; VASCULAR PAIN (non-serious), outcome "unknown", described as "pain in her vein on her leg"; INFLAMMATION (non-serious) with onset 26Sep2021, outcome "recovering", described as "felt like a little ball on her toes and a little inflamed on the other"; RASH (non-serious) with onset 23Sep2021, outcome "recovered", described as "rash on lower back"; VACCINATION SITE SWELLING (non-serious) with onset 23Sep2021, outcome "recovering", described as "swelling to injection site/pain and swelling where she got the shot"; PAIN IN EXTREMITY (non-serious) with onset 23Sep2021, outcome "recovering", described as "pain to lower leg/The pain in the leg/it was hurting"; ERYTHEMA (non-serious) with onset 23Sep2021, outcome "recovered", described as "had some redness in the bottom of her back close to her waist on the left side"; PRURITUS (non-serious) with onset 23Sep2021, outcome "recovered", described as "itchy"; VACCINATION SITE PAIN (non-serious) with onset 23Sep2021, outcome "recovering", described as "pain and swelling where she got the shot". Therapeutic measures were taken as a result of peripheral swelling, vein disorder, arthritis, bone pain, vascular pain, inflammation, rash, vaccination site swelling, pain in extremity, erythema, pruritus, vaccination site pain.  Additional information: History of all previous immunization with the Pfizer vaccine considered as suspect were none. Additional vaccines administered on same date of the Pfizer suspect were none. Ae(s) did not require a visit to emergency room or physician office. Prior vaccinations (within 4 weeks) were none. Family medical history relevant to ae(s) were none. The patient mentions she had bad veins, and it runs in her family. She had 3 siblings that died suddenly from not a heart attack but from a brain aneurysm. Her older brother died, then her younger brother who was a doctor, and her sister who was trying to turn off her computer, they all died suddenly. She was afraid because her leg pain since she got the shot. The patient received cholesterol pill every night. The patient just got the vaccine on 23sep2021, a Thursday like a week or two ago. Time the vaccination was given was before 11:20, maybe 11:00. That night the patient felt kind of itchy and had some redness in the bottom of her back close to her waist on the left side, but the next day it was off. The patient had some pain and swelling where she got the shot. The patient took 500 mg of Tylenol. The pain went down, and she put ice on it. 2 days later the patient felt like a little ball on her toes and a little inflamed on the other toe. The patient had bad circulation but the day before yesterday she still has leg pain. Yesterday the patient did a lot of walking in the house for an hour and a half. Then the patient went walking again and didn't feel that pain, but she had pain on her leg. 3 of the caller's siblings dropped dead all the same way. So, since the patient had this pain in her vein on her leg she was concerned. The patient's veins are thick and inflated. The pain in the patient's leg is of most concern. The rash and itching went away. The pain feels like her bone is hurting when she touches it where she got the shot. The patient's arm was a little inflamed but not too much. The bumps on her toes may be arthritis. The pain in the leg is there like always but she doesn't feel it right now.  No follow-up attempts are possible. No further information is expected.