Less fatigued; Skin breaking around nose and corners of lips; Vaccine site looked like the skin being eaten away, itchy; Vaccine site was now looking like the skin was being eaten away, painful; The vaccine site resembled shingles; Aching; Low grade fever; Muscle weakness/Weekness in legs; Swollen lymph glands; Hive like bumps; Itching; Lost normal limb mobility could not raise arm; Fall when stepping down from a step; foggy brained; Canker sores in my mouth; Vaccine site a circle of inflammed deep red; Vaccine site a circle of inflammed deep red; This non-serious case was reported by a consumer and described the occurrence of injection site erythema in a patient who received Herpes zoster (Shingrix) for prophylaxis.   On 06-APR-2023, the patient received Shingrix. In APR-2023, less than 2 weeks after receiving Shingrix, the patient experienced injection site erythema (Verbatim: Vaccine site a circle of inflammed deep red) and injection site inflammation (Verbatim: Vaccine site a circle of inflammed deep red). In MAY-2023, the patient experienced injection site itching (Verbatim: Vaccine site looked like the skin being eaten away, itchy), injection site pain (Verbatim: Vaccine site was now looking like the skin was being eaten away, painful), injection site vesicles (Verbatim: The vaccine site resembled shingles), pain (Verbatim: Aching), low grade fever (Verbatim: Low grade fever), muscle weakness (Verbatim: Muscle weakness/Weekness in legs), swollen lymph nodes (Verbatim: Swollen lymph glands), urticarial rash (Verbatim: Hive like bumps), pruritus (Verbatim: Itching), mobility decreased (Verbatim: Lost normal limb mobility could not raise arm), fall (Verbatim: Fall when stepping down from a step), brain fog (Verbatim: foggy brained), canker sore (Verbatim: Canker sores in my mouth) and skin breakout (Verbatim: Skin breaking around nose and corners of lips). On an unknown date, the patient experienced fatigue (Verbatim: Less fatigued). The patient was treated with antibiotics nos (Antibiotics (Brand Names Not Known)), analgesic, nos (Pain Relief (Unknown)), hydroxyzine and prednisone. The outcome of the injection site erythema, injection site inflammation, injection site itching, injection site pain, injection site vesicles, low grade fever, muscle weakness, swollen lymph nodes, urticarial rash, mobility decreased, canker sore and skin breakout were not resolved and the outcome of the pain, pruritus and fatigue were resolving and the outcome of the fall was not reported and the outcome of the brain fog was resolved.   It was unknown if the reporter considered the injection site erythema, injection site inflammation, injection site itching, injection site pain, injection site vesicles, pain, low grade fever, muscle weakness, swollen lymph nodes, urticarial rash, pruritus, mobility decreased, fall, brain fog, canker sore, fatigue and skin breakout to be related to Shingrix.     It was unknown if the company considered the injection site erythema, injection site inflammation, injection site itching, injection site pain, injection site vesicles, pain, low grade fever, muscle weakness, swollen lymph nodes, urticarial rash, pruritus, mobility decreased, fall, brain fog, canker sore, fatigue and skin breakout to be related to Shingrix.   Additional Information: GSK Receipt Date: 16-MAY-2023 The patient received the Shingrix vaccine and returned to physician two weeks later with the vaccine site a circle of inflamed deep red.  The patient was given a 5-day dose of antibiotics. The full first week of May, the patient was aching, had a low-grade fever experienced muscle weakness, had swollen lymph glands, had areas that were covered in hive like bumps and was itching, lost normal limb mobility could not raise arms or move arms behind without extreme pain, weakness in legs caused a fall when stepping down from a step, and was foggy brained.  The vaccine site was looking like the skin was being eaten away, itching and painful, not oozing. The patient returned to the physician on April 8th and was prescribed hydroxyzine for itching and told to take OTC (over the counter) pain relief. On Friday, 12th May 2023, the patient reached out to the physician and expressed continuing symptoms, adding more canker sores in mouth.  A five-day dosage of prednisone was prescribed. It took the edge off the pain and itching. Brain fog cleared up and was less fatigued. It did not relieve or lessen the weakness. On the day of reporting, the patient returned to the physician with new symptoms include skin breaking around nose and corners of lips.  The physician said that the vaccine site resembled shingles and he was pursuing research and completing a VAERS report. Lab work had been collected.