I have a problem with vision a retinal specialist diagnosed me with macular degeneration and retinal ganglion thinning; I have a problem with vision a retinal specialist diagnosed me with macular degeneration and retinal ganglion thinning; I have a general feeling of illness fatigue my breathing is getting worse and dyspnea/violently sick; Add severe fatigue I did not have any energy and I also had a lump on my injection site; I have a general feeling of illness fatigue my breathing is getting worse and dyspnea; Ongoing episodes of chills and shaking and severe diarrhea; I have a mild rash that comes and goes; I have increased joint pain more than I have had before I have joint instability muscle weakness; After relatively constant headache in the front of my head constant nausea but no vomiting trouble eating; Add severe fatigue I did not have any energy and I also had a lump on my injection site; After relatively constant headache in the front of my head constant nausea but no vomiting trouble eating; vomiting; Ongoing episodes of chills and shaking and severe diarrhea; flets; violently sick; Ongoing episodes of chills and shaking and severe diarrhea/severe diarrhea; This spontaneous case was reported by a consumer and describes the occurrence of MACULAR DEGENERATION (I have a problem with vision a retinal specialist diagnosed me with macular degeneration and retinal ganglion thinning) and RETINAL DEGENERATION (I have a problem with vision a retinal specialist diagnosed me with macular degeneration and retinal ganglion thinning) in a 75-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 051C21A and 049E21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     No medical history was provided by the reporter.  Concomitant products included CURCUMIN for Inflammation, ASCORBIC ACID, BETACAROTENE, COPPER, NICOTINAMIDE, SELENIUM, TOCOPHEROL, XANTOFYL, ZINC (LUTEIN +) for Vision abnormal NOS, LEVOTHYROXINE, LIOTHYRONINE, LISINOPRIL, ESTRADIOL, METHYLPHENIDATE, INSULIN ASPART (NOVOLOG), INSULIN GLARGINE (LANTUS), CLONAZEPAM, CAFFEINE, VITAMIN D NOS, CYANOCOBALAMIN (B12-VITAMIN), CALCIUM MEFOLINATE (L METHYLFOLATE), PYRIDOXINE HYDROCHLORIDE (B6), HYDROCODONE and ALBUTEROL SULFATE for an unknown indication.   On 14-Jul-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 11-Aug-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 01-Sep-2021, the patient experienced DIARRHEA (Ongoing episodes of chills and shaking and severe diarrhea/severe diarrhea), VACCINATION COMPLICATION (flets), ILLNESS (violently sick), CHILLS (Ongoing episodes of chills and shaking and severe diarrhea) and VOMITING (vomiting). On an unknown date, the patient experienced MACULAR DEGENERATION (I have a problem with vision a retinal specialist diagnosed me with macular degeneration and retinal ganglion thinning) (seriousness criterion medically significant), RETINAL DEGENERATION (I have a problem with vision a retinal specialist diagnosed me with macular degeneration and retinal ganglion thinning) (seriousness criterion medically significant), ILLNESS (I have a general feeling of illness fatigue my breathing is getting worse and dyspnea/violently sick), VACCINATION SITE MASS (Add severe fatigue I did not have any energy and I also had a lump on my injection site), DYSPNOEA (I have a general feeling of illness fatigue my breathing is getting worse and dyspnea), TREMOR (Ongoing episodes of chills and shaking and severe diarrhea), RASH (I have a mild rash that comes and goes), ARTHRALGIA (I have increased joint pain more than I have had before I have joint instability muscle weakness), HEADACHE (After relatively constant headache in the front of my head constant nausea but no vomiting trouble eating), FATIGUE (Add severe fatigue I did not have any energy and I also had a lump on my injection site) and NAUSEA (After relatively constant headache in the front of my head constant nausea but no vomiting trouble eating). At the time of the report, MACULAR DEGENERATION (I have a problem with vision a retinal specialist diagnosed me with macular degeneration and retinal ganglion thinning), RETINAL DEGENERATION (I have a problem with vision a retinal specialist diagnosed me with macular degeneration and retinal ganglion thinning), ILLNESS (I have a general feeling of illness fatigue my breathing is getting worse and dyspnea/violently sick), DIARRHEA (Ongoing episodes of chills and shaking and severe diarrhea/severe diarrhea), VACCINATION SITE MASS (Add severe fatigue I did not have any energy and I also had a lump on my injection site), DYSPNOEA (I have a general feeling of illness fatigue my breathing is getting worse and dyspnea), TREMOR (Ongoing episodes of chills and shaking and severe diarrhea), VACCINATION COMPLICATION (flets), ILLNESS (violently sick), RASH (I have a mild rash that comes and goes), ARTHRALGIA (I have increased joint pain more than I have had before I have joint instability muscle weakness), HEADACHE (After relatively constant headache in the front of my head constant nausea but no vomiting trouble eating), CHILLS (Ongoing episodes of chills and shaking and severe diarrhea), FATIGUE (Add severe fatigue I did not have any energy and I also had a lump on my injection site), NAUSEA (After relatively constant headache in the front of my head constant nausea but no vomiting trouble eating) and VOMITING (vomiting) outcome was unknown.            No treatment information was provided by the reporter.  Patient had suspended her inflammation medication (curcumin phytosome) so that it would not interfere with the efficacy of the vaccine. Now that she tried to take it again and discovered that she cannot go back to the old medication.  Company Comment:  Very limited information regarding these events has been provided at this time. Additional information required.   Most recent FOLLOW-UP information incorporated above includes: On 02-Sep-2021: Significant follow up received on 02 SEP 2021 included addition of start date of events and concomitant drugs.; Sender's Comments: Very limited information regarding these events has been provided at this time. Additional information required.