Increased rheumatoid arthritis; Increased rheumatoid arthritis; Her pain got worse/pain hurt more; This is a spontaneous report from a contactable consumer or other non hcp (patient) from a Pfizer sponsored program COVAX US support. A 65-year-old female patient received second dose of bnt162b2 (PFIZER-BIONTECH COVID-19 VACCINE, Solution for Injection, Batch/Lot number was not reported), via an unspecified route of administration on an unspecified date in Feb2021 as dose 2, single for COVID-19 immunization. The patient medical history included COVID-19 (patient and her husband had COVID in Dec2020) from on an unspecified date in Dec2020 to an unknown date. The patient's concomitant medications were not reported. The patient previously took first dose of bnt162b2 on an unspecified date in Jan2021 for COVID-19 immunization; orencia, humira, both drugs taken for rheumatoid arthritis and experienced was sicker on them and in bed, headaches, was sick to her stomach, trouble breathing. On an unspecified date in 2021, the patient experienced increased rheumatoid arthritis, her pain got worse/pain hurt more. Patient wanted to know if there is a potential drug interaction between Xeljanz and the Pfizer BioNtech covid-19 vaccine. Patient stated that she got both doses of the Pfizer BioNtech covid-19 vaccine and mentioned that she has increased rheumatoid arthritis. Patient is interested in getting the booster dose of the Pfizer BioNtech covid-19 vaccine however patient is concerned that Xeljanz could have some sort of interaction with the booster dose. Patient wanted to know if she needs to stop taking her xeljanz before taking the booster dose of the Pfizer BioNTech Covid-19 vaccine. Agent stated the patient had both doses of the Pfizer Covid 19 vaccine. Patient has been taking Xeljanz for two months. Patient wants to get a booster shot. Patient wants to know if she can get the booster shot while taking Xeljanz. Patient is in between doses and is not taking any other medication. Patient started taking Xeljanz after the second dose of vaccine. Patient confirmed that she is calling about the Pfizer Covid 19 vaccine, but her question is also about Xeljanz. Patient stated she and her husband had Covid in Dec2020, and then they got the shots in Jan2021 and the second shot in Feb2021. Patient stated at that time, she was on no other medication, but Depo-estradiol. Patient stated that after her second vaccine she started Xeljanz also. Patient asks does she need to stop her Xeljanz before she gets the booster shot. Patient stated she knows other people, whose Rheumatologists had then stop their medication. Patient clarified that she was put on Xeljanz, to try a new medication for her Rheumatoid Arthritis. Patient reports that she tried Orencia and Humira previously. Patient could not take those medicines and later reclarified that with both medications, she had headaches, was sick to her stomach, had trouble breathing, and was sicker on them and in bed, than before she started those medications. Patient was on them 7 to 10 years ago. Prior to that, patient was on Methotrexate, and had major problems, specifically she had pain all over her body. Could not get out of bed. She was told to stop the medication. Patient stated that she felt like she was walking on stones and felt chair and bedridden from those medications. Patient stated she has had Rheumatoid Arthritis for years, before getting the vaccines. After she got Covid, her pain got worse. After the first and second shot, her pain hurt more. Patient stated she was not on any medication at the time she had Covid. Patient started the Depoestradiol and Xeljanz in Jun2021 or Jul2021. Patient asks, is there an interaction between Xeljanz and the Covid vaccine. Outcome of the events was unknown.  The lot number for the vaccine, [BNT162B2], was not provided and will be requested during follow up.