"significant" energy drop /Loss of energy,Low energy levels; Burning in legs /his legs would burn after exercise; Leg pain; Feel breathless/ out of breathe; Made him anemic; He just could do nothing; Couldn't exercise, walking up a set of stairs became a task; Fatigue; This spontaneous case was reported by a consumer and describes the occurrence of ASTHENIA ("significant" energy drop /Loss of energy,Low energy levels), BURNING SENSATION (Burning in legs /his legs would burn after exercise), PAIN IN EXTREMITY (Leg pain), DYSPNOEA (Feel breathless/ out of breathe) and ANAEMIA (Made him anemic) in a 79-year-old male patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 031M20A and 040A21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     The patient's past medical history included Anemia and Bypass surgery. Concomitant products included CITALOPRAM, ATORVASTATIN CALCIUM (LIPITOR), BISOPROLOL FUMARATE, HYDROCHLOROTHIAZIDE (ZIAC [BISOPROLOL FUMARATE;HYDROCHLOROTHIAZIDE]) and BISOPROLOL FUMARATE, HYDROCHLOROTHIAZIDE (BISOPROLOL HCT) for an unknown indication.   On 17-Feb-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 17-Mar-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On an unknown date, the patient experienced ASTHENIA ("significant" energy drop /Loss of energy,Low energy levels), BURNING SENSATION (Burning in legs /his legs would burn after exercise), PAIN IN EXTREMITY (Leg pain), DYSPNOEA (Feel breathless/ out of breathe), ANAEMIA (Made him anemic), LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (He just could do nothing), EXERCISE TOLERANCE DECREASED (Couldn't exercise, walking up a set of stairs became a task) and FATIGUE (Fatigue). The patient was treated with IBUPROFEN for Adverse event, at an unspecified dose and frequency; CYANOCOBALAMIN (VITAMIN B12 [CYANOCOBALAMIN]) for Anemia, at an unspecified dose and frequency; IRON for Anemia, at an unspecified dose and frequency and COLECALCIFEROL (VITAMIN D [COLECALCIFEROL]) for Anemia, at an unspecified dose and frequency. At the time of the report, ASTHENIA ("significant" energy drop /Loss of energy,Low energy levels), PAIN IN EXTREMITY (Leg pain), LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (He just could do nothing) and EXERCISE TOLERANCE DECREASED (Couldn't exercise, walking up a set of stairs became a task) outcome was unknown, BURNING SENSATION (Burning in legs /his legs would burn after exercise) had not resolved and DYSPNOEA (Feel breathless/ out of breathe), ANAEMIA (Made him anemic) and FATIGUE (Fatigue) had resolved.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): In 2021, Red blood cell count (4.6-6.2): low (Low) The value was low resulted in anemia.. On 05-Jul-2021, Red blood cell count (4.6-6.2): 3.73 (Low) Decreased RBC count. On 16-Jul-2021, Red blood cell count (4.6-6.2): 4.06 (Low) Decreased RBC count. On 09-Aug-2021, Red blood cell count (4.6-6.2): 4.64 (normal) Normal RBC Count.         The consumer stated that after the second injection of Moderna COVID19 vaccine, he had a lot of trouble with fatigue and leg pain.   The consumer stated that after many tests, his doctor told him he was anemic. He took vitamin D, iron, and  B12 tablets,which brought it back up.  The consumer stated that he is very active, but his legs would burn after exercise.   This case was linked to MOD-2021-240639 (Patient Link).   Most recent FOLLOW-UP information incorporated above includes: On 09-Aug-2021: Follow-up received  and contains significant information updated patient information, product information and events. On 18-Aug-2021: Significant Follow up contains updated laboratory data, updated treatment drug and additional events. On 27-Aug-2021: Significant Follow-up. New event- fatigue added. Patient's relevant history updated. Treatment medication-vitamin D included. Events outcome updated.