depression/Severe depression; body weakness; dizziness; falling; severe weakness in my arms and legs/her body is weak in the leg, arms, hands; she can barely walk; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP) from medical information team, Program ID.  A 65-year-old female patient received BNT162b2 (BNT162B2), on 26Mar2021 as dose 2, single (Lot number: ER8733) at the age of 65 years for covid-19 immunisation. The patient's relevant medical history included: "Thyroid issues" (unspecified if ongoing), notes: Thyroid issues; "Defibrillator/pacemaker insertion" (unspecified if ongoing), notes: Defibrillator/pacemaker insertion. Concomitant medication(s) included: CLONAZEPAM, start date: Mar2022; ALPRAZOLAM, start date: Mar2022. Vaccination history included: BNT162b2 (Dose 1, Single, Lot EN6199), administration date: 05Mar2021, when the patient was 65-year-old, for COVID-19 Immunisation, reaction(s): "Dizziness", "severe depression", "her body is weak in the leg, arms, hands", "falling several times", "she can barely walk", "body weakness". The following information was reported: ASTHENIA (non-serious) with onset 2021, outcome "recovered" (2021), described as "body weakness"; DEPRESSION (non-serious) with onset 2021, outcome "recovered" (2021), described as "depression/Severe depression"; DIZZINESS (non-serious) with onset 2021, outcome "recovered" (2021); FALL (non-serious) with onset 2021, outcome "recovered" (2021), described as "falling"; MUSCULAR WEAKNESS (non-serious) with onset 2021, outcome "recovered" (2021), described as "severe weakness in my arms and legs/her body is weak in the leg, arms, hands"; GAIT DISTURBANCE (non-serious) with onset 2021, outcome "recovered" (2021), described as "she can barely walk".  Additional information: Reporter (patient's daughter) which was the caregiver wanted to know if the onset of depression, body weakness, dizziness and falling were related to the vaccine. Reporter then stated being interested in knowing if there was anything to do to reverse the side effects and how long the vaccine stays in the system. Ever since patient has gotten it (the vaccines) or actually every time she has gotten each dose, she experiences severe depression, her body is weak in the leg, arms, hands to the point she can barely walk and was falling several times. She also experiences dizziness each time, between the dizziness and weakness she has fallen a few times because of it. Reporter was wondering if there was anything she can do to reverse the side effects or help. Reporter mentioned that the patient had 5 doses of the covid vaccine and all of them are Pfizer. Patient had third dose on 03Dec2021, dose 4 on 25May2022. Fifth dose bivalent vaccine was on 26Oct2022, lot was either GJ3275 or 6J3275. She received it in the upper arm  but she does not know if it was the right or left arm. The reporter clarified that only the fifth dose was the Pfizer covid bivalent vaccine. The fifth dose was the worst for her as of side effects. Doses one to four were the monovalent covid vaccine. Reporter also clarified that each time with each dose, with the last dose being the worst, but each time her mom would experience depression, body weakness, and dizziness. During the call, reporter said she thought the patient had muscular dystrophy or something like that. The dizziness was on and off, it was not constant. The side effects happen with each vaccination; however the start of the side effects typically started a few days after getting the vaccine and gets worse. Investigation: Patient recently had a brain scan clarifying it was actually a CT scan of the brain, back and neck. She also had labs done since she is supposed to be having her hip replaced next Friday. The CT scans results had nothing, when it came back, besides showing that she has some deterioration in the hips. For the labs, she recalls it was blood work and they did a bacterial swab, she can't remember what bacteria she was positive for but she had an infection. The CT scans and lab work was back in Sep2022 and she is guessing since the doctor appointment was in early Oct2022. The patient had no allergies. Reporter states that her mom asked the doctor if she had muscular dystrophy, the doctor ruled that out, the doctor also said Parkinson's is ruled out, He ruled out all of that and said it's not what it is, they don't know what it was, but just noticed it comes on every time she gets the covid vaccines. Furthermore, it was reported that since patient started the vaccine, she overcome with depression, dizziness, and severe weakness in her arms and legs. She have fallen many times due to the weakness and dizziness. She received her last dose of the Pfizer vaccine on Wednesday 26Oct2022. The next day her depression was out of control and she could hardly walk. She came to realize it was the vaccine causing her problems.; Sender's Comments: Linked Report(s) : US-PFIZER INC-202201296028 Same patient, different dose, and event;