High thyroid hormone test long after 2nd vaccine; Increased heart rate (Flutters); Short of Breath; Within a day or two after 2nd shot, She started having swollen glands on both sides of her neck.; This spontaneous case was reported by a consumer and describes the occurrence of THYROID HORMONES INCREASED (High thyroid hormone test long after 2nd vaccine), CARDIAC FLUTTER (Increased heart rate (Flutters)), DYSPNOEA (Short of Breath) and LYMPHADENOPATHY (Within a day or two after 2nd shot, She started having swollen glands on both sides of her neck.) in a 70-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 007B21A and 026A21A) for COVID-19 vaccination.     The patient's past medical history included Heart disease, unspecified (Severe heart disease), Depression and Bypass surgery (Triple Bypass many years ago). Concurrent medical conditions included Hypothyroidism. Concomitant products included LEVOTHYROXINE SODIUM (SYNTHROID) for Hypothyroidism, CARVEDILOL, VITAMIN D3, CLOPIDOGREL BISULFATE (PLAVIX), ESCITALOPRAM OXALATE (LEXAPRO), EZETIMIBE (ZETIA), FUROSEMIDE (LASIX [FUROSEMIDE]), LISINOPRIL, ATORVASTATIN and BUPROPION for an unknown indication.   On 05-Mar-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 02-Apr-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. In April 2021, the patient experienced CARDIAC FLUTTER (Increased heart rate (Flutters)), DYSPNOEA (Short of Breath) and LYMPHADENOPATHY (Within a day or two after 2nd shot, She started having swollen glands on both sides of her neck.). On an unknown date, the patient experienced THYROID HORMONES INCREASED (High thyroid hormone test long after 2nd vaccine). The patient was treated with LEVOTHYROXINE SODIUM (SYNTHROID) for Hyperthyroidism, at a dose of 75 microgram. At the time of the report, THYROID HORMONES INCREASED (High thyroid hormone test long after 2nd vaccine) outcome was unknown and CARDIAC FLUTTER (Increased heart rate (Flutters)), DYSPNOEA (Short of Breath) and LYMPHADENOPATHY (Within a day or two after 2nd shot, She started having swollen glands on both sides of her neck.) had not resolved.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): In February 2022, Thyroid hormones test: high (High) the result was high. On an unknown date, Cardiac stress test: not heart related problems Stress test revealed not heart related problems.         Within a day or two after 2nd shot, patient had swollen glands on both sides of her neck, which mimicked her heart attack symptoms. The patient's symptoms were still lingering.  The doctor reduced the dose of the thyroid medication Synthroid 100 MCG at time of 2nd vaccination, reduced to 75MCG after vaccination.  Company Comment: This is a spontaneous case concerning a 70-year-old female patient with medical history of Hypothyroidism, Severe heart disease, and Triple Bypass, who experienced the unexpected non-serious adverse events of special interest, Cardiac Flutter and unexpected non-serious event of Thyroid Hormone Increased. Cardiac Flutter occurred approximately the same month after receiving the second dose of mRNA-1273 Vaccine while Thyroid Hormone Increased occurred on an unknown date. As reported, cardiac stress test showed no heart problems while Thyroid Hormones were elevated. The patient's physician then adjusted her Levothyroxine Sodium from 100mcg to 75mcg. It was reported that the outcome of the events was unknown. The medical history of Hypothyroidism, Severe heart disease, and Triple Bypass remains a confounder. The benefit-risk relationship of mRNA-1273 Vaccine is not affected by this report.; Sender's Comments: This is a spontaneous case concerning a 70-year-old female patient with medical history of Hypothyroidism, Severe heart disease, and Triple Bypass, who experienced the unexpected non-serious adverse events of special interest, Cardiac Flutter and unexpected non-serious event of Thyroid Hormone Increased. Cardiac Flutter occurred approximately the same month after receiving the second dose of mRNA-1273 Vaccine while Thyroid Hormone Increased occurred on an unknown date. As reported, cardiac stress test showed no heart problems while Thyroid Hormones were elevated. The patient's physician then adjusted her Levothyroxine Sodium from 100mcg to 75mcg. It was reported that the outcome of the events was unknown. The medical history of Hypothyroidism, Severe heart disease, and Triple Bypass remains a confounder. The benefit-risk relationship of mRNA-1273 Vaccine is not affected by this report.