She bled real heavy; Her menstrual cycle came/Covid-19 vaccine made her menstrual cycle come early; Stomach started feeling crampy; Arm was sore when she went to sleep on the night; This is a spontaneous report from a contactable consumer (patient). A 48-years-old female patient received bnt162b2 (PFIZER-BIONTECH COVID-19 mRNA VACCINE; Solution for injection, Lot Number: EW0161), via an unspecified route of administration in the left arm on 21Apr2021 at 12:45 (at the age of 48-years-old) as dose 2, single for COVID-19 immunization. Medical history included ongoing hypertension, she was diagnosed with high blood pressure when she was 37, about 11 years ago. Patient reported that she had 2 sisters that had Covid-19, one in May2020 and one in Jan2021. Concomitant medication(s) included amlodipine taken for high blood pressure from an unspecified start date and ongoing, she began taking amlodipine about 2 years ago, she took a different medication prior to amlodipine. Historical vaccine included first dose of bnt162b2 (PFIZER-BIONTECH COVID-19 mRNA VACCINE; Solution for injection, Lot Number: ER8734), via an unspecified route of administration in the right arm on 30Mar2021 (at the age of 48-years-old) as dose 1, single for COVID-19 immunization and her arm was swollen and hurt for a couple of days, nagging headache, pain was right between her nose. The patient did not receive any other vaccines within 4 weeks prior to the COVID-19 vaccine. Patient reported that her menstrual cycle came on Friday, 23Apr2021, reported that she bled real heavy on Saturday, 24Apr2021, Sunday, 25Apr2021. She reported that she had to keep changing her pad every 3 hours because it kept filling up, she was just bleeding real, real heavy. Patient reported that she had been moving around a lot on Saturday and Sunday and thought that could have been the cause of the heavy bleeding. Patient reported that the event scared her because her cycle isn't supposed to come until 01May2021, so the Covid-19 vaccine made her menstrual cycle come early. Patient further reported that her cycle was real light and perfect that day, 27Apr2021, she reported that at first, she thought that maybe she did too much and want to go to bed. She reported that before she went to bed, she realized that she needed to change her menstrual pad and thought to herself that she had just changed it, heavy cycle kept messing her clothes up. Her stomach started feeling crampy on Thursday, 22Apr2021, and she thought that her menstrual cycle was coming, she reported that she cramped Thursday, 22Apr2021 and Friday, 23Apr2021 and then her cycle came on. The cramps went away when her menstrual cycle started on 23Apr2021, she normally gets cramps before her menstrual cycle and thought that it was odd because she already had a period in Apr2021. Patient also noticed that her arm was sore when she went to sleep on the night of 21Apr2021. The clinical outcome for the event, her menstrual cycle came/Covid-19 vaccine made her menstrual cycle come early and she bled real heavy was recovering, arm was sore when she went to sleep on the night and stomach started feeling crampy was recovered on 23Apr2021.  No follow-up attempts are needed. No further information is expected.