WITH SECOND HUMIRA MAY HAVE TWISTED THE CAPS WHEN REMOVING/RECAPPED AND TRIED FOR INJECTION/HEARD NO CLICK/FELT NO STICK/LIFTED PEN MEDICATION POURED OUT OF THE PEN; FEVER; NAUSEA; SWOLLEN RIGHT ARM; RIGHT ARM FELT HOT; SORE THROAT; UPSET STOMACH; BODY ACHES; RIGHT SORE ARM; JOINT PAINS; LYMPH NODES WERE ALSO SWOLLEN PARTICULARLY THE ONES BELOW JAWLINE/ ABOVE CLAVICLE/ARMPIT; DIARRHEA; FELT WEAK; HEADACHES; ISSUE WITH FIRST HUMIRA/PATIENT FELT NO STICK/FELT WETNESS ON LEG/UNSURE HOW MUCH MEDICATION WAS ON THE SITE WITH HUMIRA; NOT FEELING WELL DUE TO COVID-19 VACCINE; BLOOD ON THE INJECTION SITE; MEDICATION ERROR; This spontaneous report received from a patient concerned a 30 year old female. The patient's weight was 175 pounds, and height was 62 inches. The patient's concurrent conditions included: endometriosis, polycystic ovarian syndrome, idiopathic intracranial hypertension, raynaud's syndrome, migraines, non smoker, abstains from alcohol, latex allergy, protein containing products such as egg and meat allergy, dairy products allergy, and transgender, and other pre-existing medical conditions included: The patient had non-steroidal anti-inflammatory drugs (NSAIDS) allergy manifested with stomach bleeding, opioids allergy manifested with hives, narcotics allergy manifested with hives, steroids allergy manifested by hives, topical steroids allergy manifested by blisters. The patient experienced convulsion, hallucination and vomiting when treated with escitalopram oxalate for drug used for unknown indication, and dizzy, low blood pressure, passing out and stomach upset when treated with fluconazole for drug used for unknown indication. The patient received covid-19 vaccine ad26.cov2.s (suspension for injection, intramuscular, batch number: 042A21A expiry: UNKNOWN) dose was not reported, administered on 02-APR-2021 for prophylactic vaccination. Non-company suspect drugs included: adalimumab (solution for injection in pre-filled pen, subcutaneous, batch number: 1151978) 40 mg, 1 time every 2 weeks, from 18-AUG-2021 for ankylosing spondylitis. Non-company suspect vaccine included: bnt 162 (injection, intramuscular, batch number: FC3182) dose was not reported, administered on 24-AUG-2021 for covid-19 vaccination. Concomitant medications included testosterone for hormonal replacement, cannabidiol for pain, and paracetamol for pain. On 02-APR-2021, the patient experienced medication error. On AUG-2021, the patient experienced not feeling well due to covid-19 vaccine. On AUG-2021, the patient experienced blood on the injection site. On 18-AUG-2021, the patient experienced issue with first humira/patient felt no stick/felt wetness on leg/unsure how much medication was on the site with humira. On 25-AUG-2021, the patient experienced swollen right arm. On 25-AUG-2021, the patient experienced right arm felt hot. On 25-AUG-2021, the patient experienced sore throat. On 25-AUG-2021, the patient experienced upset stomach. On 25-AUG-2021, the patient experienced body aches. On 25-AUG-2021, the patient experienced right sore arm. On 25-AUG-2021, the patient experienced joint pains. On 25-AUG-2021, the patient experienced lymph nodes were also swollen particularly the ones below jawline/ above clavicle/armpit. On 25-AUG-2021, the patient experienced diarrhea. On 25-AUG-2021, the patient experienced felt weak. On 25-AUG-2021, the patient experienced headaches. On 25-AUG-2021, the patient experienced nausea. On 26-AUG-2021, the patient experienced fever. On 04-SEP-2021, the patient experienced with second humira may have twisted the caps when removing/recapped and tried for injection/heard no click/felt no stick/lifted pen medication poured out of the pen. The action taken with covid-19 vaccine ad26.cov2.s, and bnt 162 was not applicable; and dose of adalimumab was not changed. The patient recovered from swollen right arm, right arm felt hot, and right sore arm on SEP-2021, issue with first humira/patient felt no stick/felt wetness on leg/unsure how much medication was on the site with humira on 18-AUG-2021, and fever on 30-AUG-2021, was recovering from lymph nodes were also swollen particularly the ones below jawline/ above clavicle/armpit, upset stomach, diarrhea, nausea, body aches, joint pains, and felt weak, had not recovered from sore throat, and headaches, and the outcome of not feeling well due to covid-19 vaccine, blood on the injection site, with second humira may have twisted the caps when removing/recapped and tried for injection/heard no click/felt no stick/lifted pen medication poured out of the pen and medication error was not reported. This report was non-serious.