I started feeling headache, and confused and a little dizzy; I started feeling headache, and confused and a little dizzy/I have a lot of confusion in my head.; I started feeling headache, and confused and a little dizzy; My blood sugar was low; My hands & arms were swollen really very large, had the blisters on fingers, arm, hand, looked like I had just stuck my hand; My hands and my arms were swollen really very large, had the blisters on my fingers, arm and hand; Nausea; had the blisters on my fingers and my arm and my hand, looked like I had just stuck my hand, my arm into a boiling pot of water, some on my face; got new blisters like they are showing up. So, I mean it's not going away, it's getting worse, effects are continuing to create new blisters.; I did but my skin burnt so I threw it out away because anything that touches my skin naked I mean it burn like fire.; This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP). The reporter is the patient.  A 56-year-old female patient received BNT162b2 (BNT162B2), on 21Apr2022 as dose 3 (booster), single (Lot number: FM9992, Expiration Date: Jun2022) at the age of 56 years for covid-19 immunisation. The patient's relevant medical history included: "Diabetic" (unspecified if ongoing), notes: Diabetic; "Anxiety" (unspecified if ongoing), notes: Anxiety; "Cancer" (unspecified if ongoing), notes: Cancer; "bipolar" (unspecified if ongoing), notes: Bipolar; "lymphoid issues" (unspecified if ongoing), notes: have some lymphoid issue (Not clarified) so I take some lymphoid prescription; "my left kidney removed" (unspecified if ongoing), notes: I had my left kidney removed because I had cancer; "vitiligo" (unspecified if ongoing), notes: so I take medicines like "Trilen since that the help me the vitiligo'; "pain" (unspecified if ongoing), notes: I am on pain medications not strong pain medications but pain medications; "Constipation" (unspecified if ongoing), notes: I suffered from constipation so I take medicines like "Trilen since that the help me the vitiligo. The patient took concomitant medications. Vaccination history included: Bnt162b2 (Dose 1), for COVID-19 immunization; Bnt162b2 (Dose 2), for COVID-19 immunization. The following information was reported: CONDITION AGGRAVATED (non-serious) with onset Apr2022, outcome "unknown", described as " got new blisters like they are showing up. So, I mean it's not going away, it's getting worse, effects are continuing to create new blisters."; SKIN BURNING SENSATION (non-serious) with onset Apr2022, outcome "unknown", described as "I did but my skin burnt so I threw it out away because anything that touches my skin naked I mean it burn like fire."; HEADACHE (non-serious), DIZZINESS (non-serious) all with onset Apr2022, outcome "unknown" and all described as "I started feeling headache, and confused and a little dizzy"; CONFUSIONAL STATE (non-serious) with onset Apr2022, outcome "unknown", described as "I started feeling headache, and confused and a little dizzy/I have a lot of confusion in my head."; BLOOD GLUCOSE DECREASED (non-serious) with onset Apr2022, outcome "unknown", described as "My blood sugar was low"; PERIPHERAL SWELLING (non-serious) with onset Apr2022, outcome "unknown", described as "My hands & arms were swollen really very large, had the blisters on fingers, arm, hand, looked like I had just stuck my hand"; PERIPHERAL SWELLING (non-serious) with onset Apr2022, outcome "unknown", described as "My hands and my arms were swollen really very large, had the blisters on my fingers, arm and hand"; NAUSEA (non-serious) with onset Apr2022, outcome "unknown"; BLISTER (non-serious) with onset Apr2022, outcome "unknown", described as "had the blisters on my fingers and my arm and my hand, looked like I had just stuck my hand, my arm into a boiling pot of water, some on my face". Relevant laboratory tests and procedures are available in the appropriate section. Therapeutic measures were not taken as a result of headache, confusional state, dizziness, blood glucose decreased, peripheral swelling, peripheral swelling, nausea, blister, condition aggravated, skin burning sensation.   Additional information: This is the First case out of two cases. Reporter stated, "I am calling because on 21st, my husband and I went to the (withheld). We had an appointment there and while we were there we went and received our booster. We have got nausea the one. We went to the (withheld) and we have got our boosters and we received our, the first 2 shots and the other booster (Later clarified COVID Vaccine) and the last one that was recommended. That was on the 23rd. On the way home, I started feeling headache and confused and a little dizzy. I am a diabetic (Medical history) and I just kind of assume that may be my blood sugar was low (event captured conservatively) it continued from 'day and' night. And then when I woke up the next morning, my hands and my arms were swollen really very large and I also had the blisters on my fingers and my arm and my hand. And it looked like I had just stuck my hand and my arm into like a boiling pot of water and I had some on my face. Now my husband never has any reactions at all but he also has the same swelling. He did not have any of the blistering or any of that but he had this swelling and achiness and the tired feeling and everything. So we just, we had a few things that we had to do yesterday no matter what because we have elderly parents who is in 86's they going to 'die all soon, so we only' had to do it (Further clarifications unknown). We both just kind of thought to do it and then you know getting good rest and the next day will be okay. Well, the blister popped on my finger and it's just open skin. They look horrible, I mean it looks, looks like somebody just rip my skin off my hands have got, I have got new blisters like they are showing up. So, I mean it's not going away, it's getting worse."LOT#: Consumer stated, "So the LOT# for mine FM9992 and it says that it expires on Jun2022 (Expiration date not clarified appropriately hence not captured in tab)."Medical Conditions: Consumer stated, "Yes, I have some lymphoid issues (Not clarified) so I take some lymphoid prescriptions and bipolar (captured as provided) and I have anxiety. I am sorry. I am having so much of headache I have a lot of confusion in my head so (incomplete statement)."Regular Medication: Consumer stated, "Yeah, I take vitamins every day. I also suffered from constipation so I take medicines like "Trilen since that the help me the vitiligo' when I am about to. I also suffered from, I had my left kidney removed because I had cancer (Medical history) and I have pains from the inside every time so I am on pain medications not strong pain medications but pain medications (Name not clarified hence suspect captured as unspecified medication).Treatment: Consumer stated, "No I have not, I don't. I tried to do but because my husband told to put a band aid over and something else. I did but my skin burnt so I threw it out away because anything that touches my skin naked I mean it burn like fire." Consumer stated, "Actually no, just some advice if it's working out the way it is. I mean should I keep going to the medical to the hospital or I don't know because the effects are continuing to create new blisters I don't know if I should 'take away without' or I should you know (statement incomplete)." Patient had not received Prior Vaccination.; Sender's Comments: Linked Report(s) : US-PFIZER INC-202200617884 Same product and event, different patient