Numbness in both hands, neck, knees, upper arm,; fatigue; muscle pain; knee shot injection for pain / joint pain; ican hear my joints move and crackling; Patient reports urinary incontinence/ states her incontinence got worst after the vaccine / have no feeling at all; both hands are swollen; pain is not limited to my hands; pain / whole body / extreme pain / pain is very chronic; Still cannot use my hands; zombie symptoms /I have no feeling at all; zombie symptoms as it was difficult to walk; This case was reported by a consumer via call center representative and described the occurrence of pain in hand in a 77-year-old female patient who received Herpes zoster (Shingrix) for prophylaxis.   Concurrent medical conditions included urinary incontinence.   On 2nd December 2020, the patient received the 1st dose of Shingrix. In December 2020, 1 week after receiving Shingrix, the patient experienced pain in hand, exacerbation of pain, mobility decreased, felt like a zombie and walking difficulty. On an unknown date, the patient experienced hypoesthesia, fatigue, muscle pain, joint pain, joint crepitation, urinary incontinence aggravated and hand swelling. The patient was treated with medication unknown (Knee Injection (Medication Unknown)) and oxycodone hydrochloride (Oxycontin). On an unknown date, the outcome of the pain in hand, exacerbation of pain, mobility decreased, felt like a zombie, walking difficulty, hypoesthesia, fatigue, muscle pain, joint crepitation, urinary incontinence aggravated and hand swelling were not recovered/not resolved and the outcome of the joint pain was unknown.   It was unknown if the reporter considered the pain in hand, exacerbation of pain, mobility decreased, felt like a zombie, walking difficulty, hypoesthesia, fatigue, muscle pain, joint pain, joint crepitation, urinary incontinence aggravated and hand swelling to be related to Shingrix.  Additional details were provided as follows: This case was reported by patient herself. The patient reported severe side effects for months after getting her 1st Shingrix vaccine in left arm.  The patient stated that the pain was not limited to her hands but was in the whole body and was unable to use her hands. The patient described it as zombie symptoms since it was difficult to walk and stated that the side effects did not start immediately after the injection but about a week after the vaccination.  Patient reports that around a week after getting the vaccine she had a knee shot injection for pain and that was when the symptoms got worse.  Less than a month after receiving Shingrix, the patient reported going to the emergency room on 1st January 2021 for the symptoms as numbness in my hands, neck, knees, upper arm, fatigue, joint and muscle pain, extreme pain. She could hear her joints move and crackling and stated that the pain was very chronic.  The patient stated she was provided Oxycontin at the emergency room. The patient reported that less than 4 months after receiving Shingrix, her both hands were swollen, and it had affected both sides of the body and also reported urinary incontinence, stated her incontinence got worst after the vaccine and had no feeling at all. The patient reported she had magnetic resonance imaging and visits to neurologist, chiropractor and labs.  The patient reported normally she did not get flu shots or any vaccines. Emergency room visit required. The reporter consented to follow up. This case had been linked with US2021060555, reported by same reporter.; Sender's Comments:  US-GLAXOSMITHKLINE-US2021060555:same reporter