Got first vaccine 22Dec2020. After second vaccine on 01Feb2021.; Got first vaccine 22Dec2020. After second vaccine on 01Feb2021.; my hands  burn all the time, at times like tonite bad enough that they keep me awake; the hands get swollen and tight to close everyday; the hands get swollen and tight to close everyday; inflammation; thesymptoms have been getting worse; red nodular areas; nodular areas/distinct nodule at the proximal ulnar aspect of my Left 4th finger; This is a spontaneous report from a contactable Physician, the patient. This is the second of two reports. The reporter describes events following both vaccinations in a vaccine series. This report is for those events which occurred following the second vaccination.      A 57-year-old male patient received the second dose of BNT162B2 (PFIZER-BIONTECH COVID-19 MRNA VACCINE, Lot number EL3249), intramuscularly on 01Feb2021  (at the age of 57-years-old) as a single dose in the right arm for COVID-19 vaccination. Medical history included benign prostatic hyperplasia from an unknown date. The patient's historical vaccinations included the first dose of  BNT162B2 (PFIZER-BIONTECH COVID-19 MRNA VACCINE, Lot number EJ1685) on 22Dec2020 after which he experienced inflammation, joint pain and burning sensation in the joints. Prior to the vaccination, the patient was not diagnosed with COVID-19.  The vaccination was administered at a hospital. Concomitant medications included acetaminophen (TYLENOL), tamulosin (MANUFACTURER UNKNOWN) and metoprolol (MANUFACTURER UNKNOWN) all from unspecified dates and for unknown indication. The patient did not receive any other vaccines within four weeks prior to the vaccination. Per the reporting physician, he got his first vaccine on 22Dec2020.  His MCP and PIP joints and SI joints started burning close to 3rd week in Jan2021. He had some minor SI pains intermittently before but none with hands. Continued hurting enough that he started taking Osteobiflex and fish oil and more tylenol for inflammation. After second vaccine on 01Feb2021 the symptoms he experienced after the first dose have been getting worse.  He mentioned that his hands burn all the time, at times like tonight bad enough that they keep him awake.  He has red nodular areas on some of his knuckles and a distinct nodule at the proximal ulnar aspect of my left 4th finger PIP that is uniformly erythematous. Not all knuckles have the same degree of burning, but all including thumbs have it. The SI joint pain is more variable and at time does not bother him, but the hands get swollen and tight to close everyday. He plans to start some prednisone tomorrow due to the progression of the burning. The clinical outcomes of the events burning sensation in joints worsened, swelling of hands, stiffness joints, inflammation, condition worsended, erythema, nodule on extremity were reported as not recovered. The outcomes of inappropriate schedule of vaccine administration and off label use were unknown.  It was also reported that since the vaccination, the patient had not been tested for COVID-19.; Sender's Comments: Linked Report(s) : US-PFIZER INC-2021154881 Same patient, same drug, different AE, different dose of vaccine.