diagnosed with ANCA vasculitis which is affecting his temporal lobe; oxygen does not get to his brain correclty and this affects his cognition; tired; This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP) from medical information team.  A 79 year-old male patient received bnt162b2 (BNT162B2), administered in arm, administration date 08Feb2021 (Batch/Lot number: unknown) at the age of 78 years as dose 1, single for covid-19 immunisation. Relevant medical history included: "allergies" (unspecified if ongoing), notes: allergies; "autoimmune disease" (unspecified if ongoing), notes: His husband has had this disease for 3 years now. There were no concomitant medications.  The following information was reported: VASCULITIS (non-serious) with onset 2021, outcome "unknown", described as "diagnosed with ANCA vasculitis which is affecting his temporal lobe"; OXYGEN SATURATION DECREASED (non-serious) with onset 2021, outcome "unknown", described as "oxygen does not get to his brain correclty and this affects his cognition"; FATIGUE (non-serious) with onset 2021, outcome "recovered" (2021), described as "tired". Relevant laboratory tests and procedures are available in the appropriate section.  Additional information: Prior Vaccinations (within 4 weeks): no. Patients Medical History (including any illness at time of vaccination): Provide other relevant medical history including but not limited to these conditions: diagnosed allergies, compromised immune status, respiratory illness, genetic/chromosomal abnormalities, endocrine abnormalities (including diabetes) and obesity: allergies. Relevant Tests: List other relevant diagnostic and confirmatory test results for event(s), for example, from blood tests, cerebrospinal fluid culture, bacterial sero-type, diagnostic imaging, (e.g., chest X-ray, MRI): no. The patient was diagnosed with autoimmune disease called ANCA vasculitis which was affecting his temporal lobe and the small blood vessel area. Oxygen does not get to his brain correctly and this affects his cognition. He has a lot of symptoms from this vasculitis that make it seem like dementia. He has dementia symptoms. The autoimmune disease triggered everything after the vaccine. His husband has had this disease for 3 years now. His side effect after the Pfizer Biontech COVID 19 vaccine happened a little after the vaccine and then worsened significantly after the second. At first, she thought it was just his autoimmune disease but then he got better, and it occurred after the booster as well. He is currently staying with their daughter for a little while. They were not going to take him for his 3rd shot after what happened after the first and second. After the first vaccine there was a slight difference. They thought maybe they were just imagining it. After the first dose, he was tired and slept it off. Then he was fine. All three of his vaccines were COVID. He is on his regular medications but has not started anything else or received any other vaccines. She knows he got his first two vaccines in his arms, but he does not know which ones. His current weight is 128-129 lbs. He used to weigh 139- 140 lbs, but the vasculitis caused problems with his weight.   The lot number for bnt162b2 was not provided and will be requested during follow up.