weakness in both knees to the point that she had to use, and is still currently using a walker; itching from head to toe; She is a bit sore on the right side; This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP) from medical information team. The reporter is the patient.  A 73-year-old female patient received BNT162b2 (BNT162B2), on 09May2022 as dose 3 (booster), single (Batch/Lot number: unknown) at the age of 73 years for covid-19 immunisation. The patient's relevant medical history and concomitant medications were not reported. Vaccination history included: Johnson and johnson (Primary series.), for Covid-19 Immunization; Johnson and johnson (Dose 2, Single, booster), administration date: Nov2021, for Covid-19 Immunization. The following information was reported: PRURITUS (non-serious) with onset 09May2022, outcome "recovered" (May2022), described as "itching from head to toe"; ARTHROPATHY (non-serious) with onset 10May2022, outcome "unknown", WALKING AID USER (non-serious) with onset May2022, outcome "unknown" and all described as "weakness in both knees to the point that she had to use, and is still currently using a walker"; ANXITEY (medically significant) with onset May2022, outcome "unknown", described as "I'll be dead before they put me in the ER."; ARTHRALGIA (non-serious) with onset May2022, outcome "unknown", described as "She is a bit sore on the right side". Therapeutic measures were taken as a result of pruritus. Clinical Information: Caller, female, aged 73 (DOB withheld) is calling about the Pfizer BioNTech COVID 19 vaccine. She received her first dose initially as Johnson and Johnson, then received a booster of Johnson and Johnson at one point in Nov2021. She received her second booster which was the Pfizer COVID vaccine this past Monday. Monday night she began itching from head to toe. She took what she believes contains benadryl in it which was Tylenol PM and the itching subsided. Then Tuesday, in the late afternoon, she began to feel weakness in both knees to the point that she had to use, and is still currently using a walker. She is a bit sore on the right side, but she is trying to walk as much as she can, simply because she has to. There is no way she would go to an ER, she was just in one with her husband and it was 12 hours before he could be seen. She states "I'll be dead before they put me in the ER."She spoke with a friend of hers that's an RN, and without even looking at the information said that this was a side effect that has been reported. Then spoke as per COMIRNATY- COVID-19 vaccine, mrna injection, suspension (LAB-1448-2.0, Revised 12/2021). Postmarketing Experience reported as, The following adverse reactions have been identified during postmarketing use of COMIRNATY, including under Emergency Use Authorization. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to vaccine exposure. Musculoskeletal and Connective Tissue Disorders: (no specific reports of weakness but that Musculoskeletal issues had been reported). Told patient I would refer my mother back to her primary doctor and if any signs of anaphylaxis were to occur to go to the emergency room. (essentially refer back to HCP).  The information on the batch/lot number for BNT162b2 has been requested and will be submitted if and when received.