Nine hours after shot he had a slight headache and arm pain. He also had neck pain. We gave him PEPCID and CELEBREX. He had a prescription from flare up sin the past. At 3AM on 6/11 he awoke with severe headache, severe arm pain, coughing, nausea, weakness. He could not walk, he needed assistance. He had a fever of 104 degree, his neck pain increased. We got him back to bed and he slept in when he woke up around 9:30 AM his headache was less severe and his fever was down, his leg weakness and achiness continued. He was not able to walk. This is similar to his post viral episode. He had for about the rest of June a lot of fatigue, he didn't have leg strength and had to sleep in often. The doctors were aware and told us to keep them posted. Then end of Jul/early August he started having headaches and joint pains (elbows, knees, ankles,) He also had pressure headaches. He also had Achilles pain, tailbone, and hip pain. He started school in August, and he had to call out sick because his symptoms were getting worse. He took a Covid test which was negative. The headache continued. He was still taking CELEBREX and PEPCID. He was having issue in PE. Nobody had figured out why he has had the constant headache since July. He has had MRI, Spinal Taps. He also had an episode of gastritis. He had never been on biologics for the joint pains, and he was put on the methotrexate and prednisone, and he had to go to the ER for increased heart rate from the prednisone. He was very very fatigued with everything. They also did a GI scope in December. The methotrexate caused more problems for him and he developed really severe headache and joint and sternal pain. He got very pale, they raised folic acid to counteract the effects of the methotrexate. He had full body weakness and his arms feet like they were stinging at the ends of the bone. He also had some cognitive issues and missed school for 3 weeks. He also developed ulcers probably from switching from CELEBREX to naproxen at the end of Sept. the also switched him to omeprazole. He developed scoliosis as well. His side effects were like chemo levels In January he went to school and got sick he had two COVID-9 test that came back negative and he got sick with coughing, and it threw him into progressive leg weakness and pain. He has to do extensive rehab to learn to walk again. He developed vertigo at times and separately migraines. He did antibiotics. His spinal tap showed high protein 61 and no infection. They are not sure why this is happening. He missed months of school because of the severity of the headaches especially in the mornings. He got sent home with a walker and wheelchair. His headache when away for a few hours after the spinal tap and that was the only time. He had a spinal tap in March and pressure was lower and protein was 55. The gabapentin he did for about a month and made the headaches worse. He started developing loss of conscious and Parkinson like symptoms. He has missed a lot of school and he has to do summer school and possibly repeat a grade level. His cognitive issues have been so severe to the point he had to re learn his address. He is now on EMBREL, it's helping his joints to get better, he has less headaches and is over all making some progress. He has had a genetics workup to see if there is anything.