Mild headache; This is a spontaneous report received from a contactable reporter (Other HCP, nurse). The reporter is the patient.  A 66-year-old female patient received BNT162b2 (PFIZER-BIONTECH COVID-19 VACCINE), administered in arm left, administration date 04Feb2021 at 10:00 (Batch/Lot number: unknown) at the age of 66 years, as dose 2, single for COVID-19 immunisation. Relevant medical history included: "Asthma" (ongoing), notes: Respiratory problems and asthma since she was a teen. Treated; "Thyroid cancer" (unspecified if ongoing); "Surgery - thyroid gland removed", start date: 1988, stop date: 1988; "COVID-19", start date: 06Feb2020, stop date: 18Feb2020, notes: COVID after effects: it was disrupting her breathing; "Breathing disrupted" (unspecified if ongoing), notes: Due to COVID-19; "Tremor of hands", start date: 2014 (unspecified if ongoing), notes: Not treated; "Sneezing", start date: Feb2020 (unspecified if ongoing), notes: When she had COVID; "Hair fell out", start date: Aug2020 (unspecified if ongoing); "Lethal allergy to egg white" (unspecified if ongoing). Concomitant medication(s) included: SYNTHROID taken for thyroid cancer, start date: 1988 (ongoing); ADVAIR taken for asthma. Past drug history included: Spiriva, start date: Feb2020, notes: To treat COVID-19 symptoms; Breztri; Trelegy for Respiratory problem, reaction(s): "affects QRS interval". Vaccination history included: Flu shot (First and only shot), administration date: 08Dec2020. The following information was reported: HEADACHE (non-serious) with onset 04Feb2021, outcome "recovered", described as "Mild headache". The event "mild headache" was evaluated at the physician office visit.  Additional information:  The patient stated that for 2 hours after the 1st shot she had a mild headache. She says she had COVID the year before and compared to COVID the headache was mild. She saaid COVID was severe and this one was not. She said it lasted 2 continuous hours then went away. She says it was 10 to 15 minutes after the shot and she told them as she was sitting there.  Vaccination was done in the left upper arm, high up.  Vaccine Lot Number: EN then G or 5 then 318. There were no vaccinations within 4 weeks of the BNT162b2 vaccination. Patient's medical history and past drug history information: She says she has no thyroid gland. She says she had been taking synthroid since her surgery; she was around 33 years old, and she is 66 now, so for 33 years. The patient was sill battling the COVID after effects, it was disrupting her breathing. She says she was taking a lot of medications, a lot of neurological medications. She says the only other pertinent thing was that she has been having tremors that started 7 years prior to the initial reporting, in the one hand. She added that  just before she got the COVID virus, a week before, tremors started in the other hand and progressed rapidly. It was remarked that she thinks she was infected when this started. She said the other one took 7 years to be once a day while this one progressed to be daily. She said she was not taking anything for that, she was just trying to increase her activity levels. She said when she was 30 or 40 she was very active. She said the doctors thought there was something wrong with her immune system. She said they were trying her on different medications for asthma; they changed it, added more. She said ever since COVID in 2020, the first week of Feb2020 she thought it was the flu. She said she didn't get any medical help, she was in severe shape, and her headache was severe. She said she crawled to the bathroom once a day, she had a high fever and it felt like a snake effect of a cobra all over, squeezing. She said her pulmonologist gave her Spiriva and that has opened her up, once a day. The patient had gotten to the point she couldn't take 5 or 6 steps and couldn't breathe. She gained a ton of weight cause she couldn't move related to this breathing issue. She thought she wouldn't recover. She said when she had COVID she was sneezing and in August her hair fell out. She said she had a fever for 4 days that week then she went away. She said she wondered if she had the long haul COVID. She said the doctor gave her something to make her lungs spring open. According to the reporter the event headache was reported as non-serious.    No follow-up attempts are possible. No further information is expected.; Sender's Comments: Linked Report(s) : US-PFIZER INC-2021493407 same patient/drug, different vaccine dose/event.