small nodules at the injection sites; large painful nodule on the left side of the chin; nodule on the left side of the chin that was 3-4 cm in size and was warm; nodule on the left side of the chin that was 3-4 cm in size and was red; Swelling was down on the left side of the chin but now up on the right side of the chin; experienced bruising; Covid vaccine hypersensitivity; This spontaneous case was reported by a physician and describes the occurrence of VACCINATION SITE NODULE (small nodules at the injection sites), NODULE (large painful nodule on the left side of the chin), FEELING HOT (nodule on the left side of the chin that was 3-4 cm in size and was warm), ERYTHEMA (nodule on the left side of the chin that was 3-4 cm in size and was red) and SWELLING FACE (Swelling was down on the left side of the chin but now up on the right side of the chin) in a female patient of an unknown age who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.    Co-suspect products included non-company products HYALURONIC ACID, LIDOCAINE (RESTYLANE L) for an unknown indication and HYALURONIC ACID (BELOTERO) for an unknown indication.    Previously administered products included for Drug use for unknown indication: Belotero (This was prior to when she became the physician's patient.) in 2014, Belotero (This was prior to when she became the physician's patient.) in 2015, Restylane-L on 11-Jul-2018, Restylane-L on 22-Aug-2018 and Restylane-L (injected into the vertical lines above and below the lips (physician called them cigarette lines).) on 10-Jul-2019. Past adverse reactions to the above products included No adverse event with Belotero, Belotero, Restylane-L, Restylane-L and Restylane-L.   In January 2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. In February 2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 09-Jun-2021, the patient received dose of HYALURONIC ACID, LIDOCAINE (RESTYLANE L) (unknown route) 1 dosage form. On 21-Sep-2021, received dose of HYALURONIC ACID, LIDOCAINE (RESTYLANE L) (unknown route) dosage was changed to 1 dosage form. On 09-Feb-2022, the patient received dose of HYALURONIC ACID (BELOTERO) (unknown route) 1 dosage form. On an unknown date, the patient experienced VACCINATION SITE NODULE (small nodules at the injection sites), NODULE (large painful nodule on the left side of the chin), FEELING HOT (nodule on the left side of the chin that was 3-4 cm in size and was warm), ERYTHEMA (nodule on the left side of the chin that was 3-4 cm in size and was red), SWELLING FACE (Swelling was down on the left side of the chin but now up on the right side of the chin), CONTUSION (experienced bruising) and HYPERSENSITIVITY (Covid vaccine hypersensitivity). The patient was treated with TRIAMCINOLONE ACETONIDE (KENALOG 40) at a dose of 1 dosage form,i ntralesional 4mg/cc; CIPROFLOXACIN at a dose of 500 milligram twice a day; AZITHROMYCIN at a dose of 500 milligram; PREDNISONE at an unspecified dose and frequency and HYALURONIDASE (VITRASE) at a dose of 1 dosage form. At the time of the report, VACCINATION SITE NODULE (small nodules at the injection sites) had resolved, NODULE (large painful nodule on the left side of the chin) had not resolved and FEELING HOT (nodule on the left side of the chin that was 3-4 cm in size and was warm), ERYTHEMA (nodule on the left side of the chin that was 3-4 cm in size and was red), SWELLING FACE (Swelling was down on the left side of the chin but now up on the right side of the chin), CONTUSION (experienced bruising) and HYPERSENSITIVITY (Covid vaccine hypersensitivity) outcome was unknown.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On an unknown date, Skin test: results not reported skin test for allergy: Results not reported.     For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown), the reporter considered HYPERSENSITIVITY (Covid vaccine hypersensitivity) to be related. No further causality assessments were provided for VACCINATION SITE NODULE (small nodules at the injection sites), NODULE (large painful nodule on the left side of the chin), FEELING HOT (nodule on the left side of the chin that was 3-4 cm in size and was warm), ERYTHEMA (nodule on the left side of the chin that was 3-4 cm in size and was red), SWELLING FACE (Swelling was down on the left side of the chin but now up on the right side of the chin) and CONTUSION (experienced bruising).    Concomitant drugs were not reported.  Physician also reported that the patient had her skin tested  with Vitrase 20 units to left forearm to check for allergy.  Patient was also treated with potential biofilm infection.