lot of stress in her life; Leg cramps; hives; Chills; fever; tired; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP) from medical information team. The reporter is the patient.  A 75-year-old female patient received BNT162b2 (COMIRNATY), on 01Apr2022 at 10:15 as dose 4 (booster), single (Lot number: 9895) at the age of 75 years, in left arm for covid-19 immunisation. The patient's relevant medical history included: "High blood pressure" (unspecified if ongoing); "high cholesterol" (unspecified if ongoing); "acid reflux" (unspecified if ongoing); "BRIP1 genetic mutation" (unspecified if ongoing). There were no concomitant medications. Vaccination history included: BNT162b2 (Dose: 3, Lot: FF8839, expiration is unknown, injected in left arm), administration date: 28Sep2021, when the patient was 74-year-old, for Covid-19 Immunization; BNT162b2 (Dose: 2, Lot: EN6203, expiration unknown, injected in left arm), administration date: 26Feb2021, when the patient was 73-year-old, for Covid-19 Immunization; BNT162b2 (Dose: 1, Lot: EM9809, expiration is unknown, injected in left arm.), administration date: 05Feb2021, when the patient was 73-year-old, for Covid-19 Immunization; shingles vaccine (She had Shingles vaccine, Shingrix on 22Feb2022), administration date: 22Feb2022, when the patient was 74-year-old, for Immunization. The following information was reported: CHILLS (non-serious) with onset Apr2022, outcome "recovered"; MUSCLE SPASMS (non-serious) with onset Apr2022, outcome "recovered", described as "Leg cramps"; PYREXIA (non-serious) with onset Apr2022, outcome "recovered", described as "fever"; URTICARIA (non-serious) with onset Apr2022, outcome "not recovered", described as "hives"; FATIGUE (non-serious) with onset Apr2022, outcome "recovered", described as "tired"; STRESS (non-serious), outcome "unknown", described as "lot of stress in her life". The events "lot of stress in her life", "leg cramps", "hives", "chills", "fever" and "tired" required physician office visit and emergency room visit. Relevant laboratory tests and procedures are available in the appropriate section. Therapeutic measures were taken as a result of stress, muscle spasms, urticaria, chills, pyrexia, fatigue.  Additional information: Caller reported hives after she had my 4th booster shot. Seeking information if others have reported this side effect. Caller states the side effect was not within 4-hour window, shot was on Friday and then she woke up with hives Monday morning and she still has them. The only place the hives are not prevalent on is her face, arms and feet. When asked to provide outcome, she stated that she takes Benadryl at night, so next day some are better, but she will have a new bunch, so she is continually breaking out. They have decreased or changed and are not as inflamed looking. The Benadryl does help.  She takes no other medications other than her normal blood pressure and cholesterol medications, which she was taking prior to getting the vaccine. She did take a steroid and finished it 28Mar2022. It was Prednisone and you took 20 mg for 3 days and then 10 mg for 4 days. She saw her primary care and suggested she use hydrocortisone and take Benadryl and keep an eye on it. If it got any worse to call She got Chills, Leg cramps, fever and was tired. It lasts for 12 hours and it is gone. So it was Between 10 am in the morning when she got the shot until 10am next day.