Felt ill; Swelling; Short of breath; Anxiety worsened right after the vaccine; Depression worsened right after the vaccine; felt too dizzy to work out; easily fatigued; Aches/pains; This spontaneous case was reported by a physician and describes the occurrence of MALAISE (Felt ill), SWELLING (Swelling), DYSPNOEA (Short of breath), ANXIETY (Anxiety worsened right after the vaccine) and DEPRESSION (Depression worsened right after the vaccine) in a  patient of an unknown age and gender who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 prophylaxis. The occurrence of additional non-serious events is detailed below.     The patient's past medical history included Migraine headache, Substance abuse, Drug abuse (In sustained remission), Cannabis abuse, in remission and Smoker. Concurrent medical conditions included Asthma, Generalized anxiety disorder, Trichotillomania, Panic disorder, Mood disorder, Obstructive sleep apnea syndrome (Unspecified type), Allergy to antibiotic (Amoxicillin), Shortness of breath, Wheezing and Depression. Concomitant products included ZOLPIDEM TARTRATE (AMBIEN) for Obstructive sleep apnea syndrome, LORAZEPAM (ATIVAN) for Panic attack and Anxiety, ALBUTEROL [SALBUTAMOL] for Shortness of breath and Wheezing, GABAPENTIN (NEURONTIN [GABAPENTIN]) and ETHINYLESTRADIOL, LEVONORGESTREL (PORTIA-28) for an unknown indication.   On 21-Apr-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 19-May-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. In 2021, the patient experienced MALAISE (Felt ill), SWELLING (Swelling), DYSPNOEA (Short of breath), ANXIETY (Anxiety worsened right after the vaccine), DEPRESSION (Depression worsened right after the vaccine), DIZZINESS (felt too dizzy to work out), FATIGUE (easily fatigued) and MYALGIA (Aches/pains). The patient was treated with DIPHENHYDRAMINE HYDROCHLORIDE (BENADRYL [DIPHENHYDRAMINE HYDROCHLORIDE]) at an unspecified dose and frequency and PREDNISONE at an unspecified dose and frequency. At the time of the report, MALAISE (Felt ill), SWELLING (Swelling), DYSPNOEA (Short of breath), ANXIETY (Anxiety worsened right after the vaccine), DEPRESSION (Depression worsened right after the vaccine), DIZZINESS (felt too dizzy to work out), FATIGUE (easily fatigued) and MYALGIA (Aches/pains) outcome was unknown.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): In 2021, Blood pressure measurement: 123/70 mmHg sitting. In 2021, Body temperature: 99.2 degrees fahrenheit. In 2021, Breath sounds: normal. In 2021, Heart rate: Normal and 60 heart beats per minute. In 2021, Heart sounds: normal. In 2021, Physical examination: oriented to time/ person/ place and was in no distress.     For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown), the reporter did not provide any causality assessments.   On 21-Jun-2021, patient presented to physician after having experienced side effects to Moderna vaccine. Patient felt ill and had aches and pain after first dose and felt ill and short of breath after second dose. It was reported that swelling returned after stopping prednisone. Patient heart rhythm was regular. Distal pulses noted. Breathing sound was normal with no wheezes, no rales and was in no respiratory distress. Range of motion were normal and had no cervical adenopathy. Muscle tone and coordination were normal. Skin was warm and dry with no rashes. The patient system review was positive for malaise, fatigue, myalgia and dizziness and negative for chills, fever and weight loss. Neurologically, system review was negative for tremors, sendory and speech change and focal weaknesses. Time would resolve the events and the physician discussed that this could take 2 months after second vaccine. The physician diagnosed as adverse effect of unspecified Coronavirus drug/ vaccine.