This spontaneous case was reported by a patient and describes the occurrence of OROPHARYNGEAL PAIN (Sore throat), COUGH (Cough), DECREASED APPETITE (Loss of appetite), NASOPHARYNGITIS (Cold-like symptoms) and DYSGEUSIA (Metallic taste in mouth came back) in a 45-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 012F21A, 019B21A and 011A21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.    Co-suspect product included non-company product NIRMATRELVIR, RITONAVIR (PAXLOVID) for COVID-19 treatment.    Concurrent medical conditions included Depression and Migraine. Concomitant products included PROPRANOLOL from 03-Jan-2022 to an unknown date for Blood pressure management, BUPROPION HYDROCHLORIDE (WELLBUTRIN) from 03-Jun-2013 to an unknown date for Depression, NAPROXEN from 19-Feb-2013 to an unknown date and SUMATRIPTAN (IMITREX [SUMATRIPTAN]) from 19-Mar-2013 to an unknown date for an unknown indication.   On 02-Mar-2021, the patient received dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 02-Apr-2021, received dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 22-Oct-2021, received dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 09-May-2022, the patient started NIRMATRELVIR, RITONAVIR (PAXLOVID) (unknown route) at an unspecified dose. On 10-May-2022, the patient experienced DYSGEUSIA (While taking Paxlovid had metallic taste in my mouth, chest felt heavy and very lethargic), CHEST DISCOMFORT (While taking Paxlovid had metallic taste in my mouth, chest felt heavy and very lethargic) and LETHARGY (While taking Paxlovid had metallic taste in my mouth, chest felt heavy and very lethargic). On 16-May-2022, the patient experienced OROPHARYNGEAL PAIN (Sore throat), COUGH (Cough), DECREASED APPETITE (Loss of appetite), CHILLS (Chills), MYALGIA (Body aches) and PYREXIA (Fever). On 22-May-2022, the patient experienced NASOPHARYNGITIS (Cold-like symptoms). 22-May-2022, the patient experienced DYSGEUSIA (Metallic taste in mouth came back). On 13-May-2022, DYSGEUSIA (While taking Paxlovid had metallic taste in my mouth, chest felt heavy and very lethargic), CHEST DISCOMFORT (While taking Paxlovid had metallic taste in my mouth, chest felt heavy and very lethargic) and LETHARGY (While taking Paxlovid had metallic taste in my mouth, chest felt heavy and very lethargic) had resolved with sequelae. At the time of the report, OROPHARYNGEAL PAIN (Sore throat), COUGH (Cough), DECREASED APPETITE (Loss of appetite), NASOPHARYNGITIS (Cold-like symptoms), DYSGEUSIA (Metallic taste in mouth came back), CHILLS (Chills), MYALGIA (Body aches) and PYREXIA (Fever) outcome was unknown. DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): In May 2022, SARS-CoV-2 test: negative (Negative) Still testing negative for COVID. On 16-May-2022, SARS-CoV-2 test: negative (Negative) Rapid test came back negative. On 13 May 2022, patient stopped taking Paxlovid and felt fine. On 16 May 2022, patient woke up in the middle of the night and had all the symptoms of COVID. Treatment for the symptoms were not reported.