instantly when she came home she was tired and crashed; When she woke up she noticed that her forearms were itchy and then so were her shoulders and her hands were hivey; When she woke up she noticed that her forearms were itchy and then so were her shoulders and her hands were hivey; It was blotchy; she has developed hives and a rash all over her; it almost looked like eczema; This is a spontaneous report from a contactable consumer (patient). A 38-year-old old female patient received first dose of BNT162B2 (PFIZER-BIONTECH COVID-19 mRNA VACCINE, Solution for injection, Lot Number: ER8736), via an unspecified route of administration, administered in arm left on 04May2021 12:00 (at the age of 38-year-old) as single dose for COVID-19 immunization. Medical history included ongoing Graves' disease which was diagnosed 8 years ago, allergic reaction to Sulfa. Concomitant medication(s) included LEVOTHYROXINE taken for Graves' disease from an unspecified start date (taking this 8 years ago) and ongoing. The patient had no additional vaccines administered (on same date as Pfizer vaccine considered as suspect). The patient had no prior vaccination (within 4 weeks prior). The patient had no relevant family history related to AE(S). It was reported that patient would like to report the following side effect that she experienced post administration of the PFIZER-BIONTECH COVID-19 VACCINE. She mentioned she got her first dose noontime, EST. She came home tired, but she mentioned this might be just because of work. She had a nap and when she woke up and developed hives all over her body which was very itchy. Patient confirmed that she did not experience any difficulty in breathing at all. The patient's side effect was that she had developed hives and a rash all over her, but she did not experience any shortness of breathing or difficulty. Just the hives and all and being itchy. On 04May2021, when she came home after having her COVID vaccine she was tired, and said to her son that it could just be related to her running around with the medical field in general. She had been tired because she had worked a lot of double shifts lately. But instantly when she came home she was tired and crashed. When she woke up she noticed that her forearms were itchy and then so were her shoulders and also her hands were hivey. She has had a similar reaction when she had an allergic reaction to sulfa except her hives weren't as bright as they were now with the Sulfa. She was itchy from the top of her forehead all the way down to the MCT joint. Her toes didn't itch but she was itching all the way down to her metatarsals. She called the hospital and their emergency room to see about what to do but they were useless. She didn't go to her hospital because she didn't want people that she works with to know all about her and what was happening with her. She got her COVID vaccine on 04May2021, around 1200. She still had some hive spots but they were very light. She took Benadryl and it got better. As far as the spots being raised, they were not raised anymore but it almost looked like eczema. It was blotchy. AE(s) did not require a visit to emergency room or physician office. The patient had no relevant tests. Outcome of the event fatigue was not recovered, hives, itching was recovering, and other events was unknown.  No follow-up attempts are possible. No further information is expected.