Had pain under bony areas around eyes and pain behind right eye; Had a growth develop in upper part of left eyelid and another growth develop just below lower left eyelid; intense pain to the lower two or three inches of base of thumb, after the third dose; performed an operation and removed the growth lodged in left eyelid and lower left eyelid; Had intense diarrhea for 6 days; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP) from medical information team. The reporter is the patient.  A male patient received BNT162b2 (BNT162B2), on 12Dec2021 as dose 3 (booster), single (Lot number: FJ3757), in left arm for covid-19 immunisation; fluorouracil (EFUDEX), (Batch/Lot number: unknown). The patient's relevant medical history and concomitant medications were not reported. Vaccination history included: BNT162b2 (First dose, lot: EN6198 or could be EN6195, NDC: unknown , Expiration: unknown), administration date: 23Feb2021, for COVID-19 Immunization; BNT162b2 (Second dose, lot: EP7534, NDC: unknown , Expiration: unknown), administration date: 16Mar2021, for COVID-19 Immunization, reaction(s): "whole swelling across, underneath lower lip", "facial swelling", "Actinic Cheilitis", "diarrhea", "The caller was bleeding and scabbing for weeks and finally healed up", "intense pain to lower two or three inches of base of spine that lasted for 5 hours". The following information was reported: DIARRHOEA (non-serious) with onset 12Dec2021, outcome "recovered" (18Dec2021), described as "Had intense diarrhea for 6 days"; EYELID OPERATION (medically significant) with onset 07Feb2022, outcome "unknown", described as "performed an operation and removed the growth lodged in left eyelid and lower left eyelid"; BONE PAIN (non-serious), outcome "unknown", described as "Had pain under bony areas around eyes and pain behind right eye"; EYELID DISORDER (non-serious), outcome "unknown", described as "Had a growth develop in upper part of left eyelid and another growth develop just below lower left eyelid"; PAIN IN EXTREMITY (non-serious), outcome "unknown", described as "intense pain to the lower two or three inches of base of thumb, after the third dose". The events "performed an operation and removed the growth lodged in left eyelid and lower left eyelid", "had intense diarrhea for 6 days", "had pain under bony areas around eyes and pain behind right eye" and "had a growth develop in upper part of left eyelid and another growth develop just below lower left eyelid" required physician office visit. The event "intense pain to the lower two or three inches of base of thumb, after the third dose" required physician office visit and emergency room visit. The patient underwent the following laboratory tests and procedures: Biopsy: Benign, notes: states biopsies were sent to lab and growths came back benign. The action taken for fluorouracil was unknown.  Clinical information: Consumer had intense pain to the lower two or three inches of base of thumb, after the third dose. Had intense diarrhea for 6 days: After third dose Pfizer Covid Vaccine on 12Dec2021, the caller immediately had intense diarrhea for 6 days, began within hours.  Had pain under bony areas around eyes and pain behind right eye: The caller also had pain under bony areas around eyes and pain behind right eye. Had a growth develop in upper part of left eyelid and another growth develop just below lower left eyelid: The caller had a growth develop in upper part of left eyelid and another growth develop just below lower left eyelid. The caller's Ophthalmologist, performed an operation and removed the growth lodged in left eyelid and lower left eyelid. The growths were sent to the lab and came back benign. Both of the growths happened quickly after receiving the third dose Pfizer Covid Vaccine.  Follow-up attempts are completed. No further information is expected.