sore throat and lymph nodes along jaw line swell and hurt; sore throat and lymph nodes along jaw line swell and hurt; sore throat and lymph nodes along jaw line swell and hurt; headache; within 2 hours all glands including in back of neck are very swollen so stiff and thick neck.; within 2 hours all glands including in back of neck are very swollen so stiff and thick neck.; feeling sick; rash; body stressed; sleeplessness; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP). The reporter is the patient.  A 52-year-old female patient (not pregnant) received BNT162b2, BNT162b2 omi ba.4-5 (BNT162B2, BNT162B2 OMI BA.4-5), on 08Oct2022 at 14:45 as dose 4 (booster), single (Lot number: GH9703) at the age of 52 years, in left arm for covid-19 immunisation. The patient's relevant medical history included: "Chronic Fatigue Syndrome" (unspecified if ongoing); "chronic myofascial pain" (unspecified if ongoing), notes: chronic myofascial pain; "POTS" (unspecified if ongoing), notes: POTS. The patient took concomitant medications. Vaccination history included: moderna (Dose Number: 2, single, Is bivalent=False, Batch/Lot No: OUDB21A, Location of injection: Arm Left), administration date: 10Apr2021, when the patient was 50-year-old, for COVID-19 immunization; moderna (Dose Number: 1, single, Is bivalent=False, Batch/Lot No: 002B21A, Location of injection: Arm Left), administration date: 10Mar2021, when the patient was 50-year-old, for COVID-19 immunization; BNT162b2 (Dose Number: 3 (Booster), single, Is bivalent=False, Batch/Lot No: FF2593, Location of injection: Arm Left), administration date: 29Nov2021, when the patient was 51-year-old, for Covid-19 immunization, reaction(s): "Dose 2: Moderna / Dose 3: Pfizer", "headache", "sore throat and lymph nodes along jaw line swell and hurt", "sore throat and lymph nodes along jaw line swell and hurt", "sore throat and lymph nodes along jaw line swell and hurt". The following information was reported: STRESS (non-serious) with onset 08Oct2022, outcome "recovering", described as "body stressed"; MALAISE (non-serious) with onset 08Oct2022, outcome "recovering", described as "feeling sick"; RASH (non-serious) with onset 08Oct2022, outcome "recovered" (Oct2022); INSOMNIA (non-serious) with onset 08Oct2022, outcome "recovering", described as "sleeplessness"; SWELLING (non-serious), MUSCULOSKELETAL STIFFNESS (non-serious) all with onset 08Oct2022, outcome "recovering" and all described as "within 2 hours all glands including in back of neck are very swollen so stiff and thick neck."; HEADACHE (non-serious) with onset 08Oct2022 at 14:54, outcome "recovering"; OROPHARYNGEAL PAIN (non-serious), LYMPHADENOPATHY (non-serious), LYMPH NODE PAIN (non-serious) all with onset 08Oct2022 at 15:10, outcome "recovering" and all described as "sore throat and lymph nodes along jaw line swell and hurt". The events "headache", "sore throat and lymph nodes along jaw line swell and hurt", "within 2 hours all glands including in back of neck are very swollen so stiff and thick neck.", "feeling sick", "rash", "body stressed" and "sleeplessness" required emergency room visit. Therapeutic measures were taken as a result of headache, oropharyngeal pain, lymphadenopathy, lymph node pain, swelling, musculoskeletal stiffness, malaise, rash, stress, insomnia.  Additional information:She experienced headache 9 minutes after shot (has happened with every mRNA vaccine), 25 minutes after shot - sore throat and lymph nodes along jaw line swell and hurt (has happened 10 hours after 1st shot, 1.5 hours after second, and 30 min after 3rd), within 2 hours all glands including in back of neck were very swollen so stiff and thick neck. In bed feeling sick. Back of neck resolves overnight, but sore throat and front neck and jawline glands were extremely swollen. Basically eating advil. About 30 hours after shot, they got better after she got a rash she get when body stressed. Rash lasts a couple of days. Take benadryl and advil. Within 12hours of rash leaving, the glands and throat were bad again. Eat more advil. Unable to see doctor. Go to ER on the 15Oct2022, told vaccine reaction. On 17Oct2022, still can't see doctor, but prescribes prednisone. She took it for 5 days 10mg, then 5mg then 2.5 mg due to sleeplessness. It helped pretty immediately. It took to about the 20th for throat/lymph resolve. No other vaccine in four weeks. She received other medications in two weeks. No covid prior vaccination. She was not tested for covid post vaccination. She had no known allergies.  No follow-up attempts are possible. No further information is expected.