Heart palpitations; Tachycardia/Heart was beating very fast; Itching; Injection site started to itch; soreness at the injection site; Feeling tired; Arm was sore; This spontaneous case was reported by a consumer and describes the occurrence of PALPITATIONS (Heart palpitations), TACHYCARDIA (Tachycardia/Heart was beating very fast), PRURITUS (Itching), VACCINATION SITE PRURITUS (Injection site started to itch) and VACCINATION SITE PAIN (soreness at the injection site) in a 64-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 05K21A, 052Z21A, 031L20A and 012L20A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     The patient had known allergies, however the details were not provided.   The patient had never been positive or been diagnosed with COVID-19.    On 08-Jan-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 09-Feb-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. On 26-Nov-2021, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. On 12-Apr-2022, received fourth dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. On 12-Apr-2022, the patient experienced PALPITATIONS (Heart palpitations), TACHYCARDIA (Tachycardia/Heart was beating very fast), PRURITUS (Itching), VACCINATION SITE PRURITUS (Injection site started to itch), VACCINATION SITE PAIN (soreness at the injection site), FATIGUE (Feeling tired) and PAIN IN EXTREMITY (Arm was sore). On 12-Apr-2022, PALPITATIONS (Heart palpitations), TACHYCARDIA (Tachycardia/Heart was beating very fast), PRURITUS (Itching) and VACCINATION SITE PRURITUS (Injection site started to itch) had resolved. At the time of the report, VACCINATION SITE PAIN (soreness at the injection site) outcome was unknown and FATIGUE (Feeling tired) and PAIN IN EXTREMITY (Arm was sore) had not resolved.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On 12-Apr-2022, Blood pressure measurement: increased (High) blood pressure was high. On 12-Apr-2022, Blood test: results not reported Results not reported. On 12-Apr-2022, Blood urine: results not reported Results not reported. On 12-Apr-2022, Electrocardiogram: abnormal (abnormal) EKG was not normal. On 12-Apr-2022, Heart rate: fast (High) heart was beating fast. In April 2022, Electrocardiogram: normal (normal) EKG was normal in the ER.     For mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular), the reporter considered PALPITATIONS (Heart palpitations), TACHYCARDIA (Tachycardia/Heart was beating very fast), PRURITUS (Itching), VACCINATION SITE PRURITUS (Injection site started to itch), VACCINATION SITE PAIN (soreness at the injection site), FATIGUE (Feeling tired) and PAIN IN EXTREMITY (Arm was sore) to be related.    The patient did not provide concomitant medication details.  Patient reported of adverse reaction after receiving the 4th (2nd booster) moderna vaccine dose. The patient stated that after the shot, the injection site started to itch which never happened before. The HCP (pharmacist) called 911 immediately and they took her to the ER but was not hospitalized. In the ambulance patient stated that she had tachycardia, heart was beating fast, blood pressure was high and EKG was not normal.   The patient have went to ER and was given prescription for EpiPen. However, it was reported no medication was received.   Most recent FOLLOW-UP information incorporated above includes: On 12-Apr-2022: Follow up received. Updated the administration date of the second  booster dose.