Patient had "C.diff" infection; This spontaneous case was reported by a consumer and describes the occurrence of CLOSTRIDIUM DIFFICILE INFECTION (Patient had "C.diff" infection) in a 66-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination.     No Medical History information was reported.    On an unknown date, the patient received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 14-Apr-2022, the patient experienced CLOSTRIDIUM DIFFICILE INFECTION (Patient had "C.diff" infection) (seriousness criteria hospitalization and medically significant). The patient was hospitalized for 2 days due to CLOSTRIDIUM DIFFICILE INFECTION. The patient was treated with VANCOMYCIN for Clostridium difficile infection, at a dose of 14 days course. At the time of the report, CLOSTRIDIUM DIFFICILE INFECTION (Patient had "C.diff" infection) outcome was unknown.            Concomitant product use was not provided by the reporter. The patient finished the 14 days course of Vancomycin for "C.diff" infection that patient had on 14 Apr 2022. The patient was unable to provide any additional information such as lots, expiration dates for the patient.  Company Comment: This spontaneous case concerns a 66 year old female patient  with no medical history reported, who experienced Serious ( Medically significant , hospitalization ) , unexpected event of Clostridium difficle infection which occurred on 14-04-2022 post vaccination with the 3rd dose of mRNA-1273 vaccine. The details regarding the dose 1 and dose 2 of the Covid 19 vaccine of this patient was not reported and also the date of the 3rd dose of the mRNA-1273 vaccine was not reported. This patient was hospitalized for two days and has completed the 14 days course of Vaccomycin for the treatment of the Clostridium difficile infection . The other details regarding the events like signs and symptoms , laboratories /diagnostic procedures done were not reported , also there was no report of previous antibiotic treatment  of the patient.  Outcome of the events was reported as unknown. The age of this patient is considered as confounder since age 65 and above  is reported as a risk factor to develop Clostridium difficile infection . The benefit -risk relationship of mRNA -1273 ( Moderna Covid 19 Vaccine) is not affected by this report.; Sender's Comments: This spontaneous case concerns a 66 year old female patient  with no medical history reported, who experienced Serious ( Medically significant , hospitalization ) , unexpected event of Clostridium difficle infection which occurred on 14-04-2022 post vaccination with the 3rd dose of mRNA-1273 vaccine. The details regarding the dose 1 and dose 2 of the Covid 19 vaccine of this patient was not reported and also the date of the 3rd dose of the mRNA-1273 vaccine was not reported. This patient was hospitalized for two days and has completed the 14 days course of Vaccomycin for the treatment of the Clostridium difficile infection . The other details regarding the events like signs and symptoms , laboratories /diagnostic procedures done were not reported , also there was no report of previous antibiotic treatment  of the patient.  Outcome of the events was reported as unknown. The age of this patient is considered as confounder since age 65 and above  is reported as a risk factor to develop Clostridium difficile infection . The benefit -risk relationship of mRNA -1273 ( Moderna Covid 19 Vaccine) is not affected by this report.