this occurred on 20Jul2021, it was an ischemic stroke; Caller states that because of the stroke, her husband also has vascular dementia; hypertension; headache; arm hurt; arm hurt right away and then hurt for 2 years at injection site; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP) from medical information team.   A 49-year-old male patient received BNT162b2 (BNT162B2), on 13Feb2021 as dose 2, single (Lot number: EL9265) at the age of 49 years for covid-19 immunization. The patient's relevant medical history included: "Heart Catheter", start date: 2020 (unspecified if ongoing). The patient's concomitant medications were not reported. Vaccination history included: BNT162b2 (DOSE 1, SINGLE, Batch/lot number: EL3249, Dosage text: First Dose; Left Arm), administration date: 23Jan2021, when the patient was 49-year-old, for COVID-19 immunization, reaction(s): "arm hurt", "arm hurt right away and then hurt for 2 years at injection site". The following information was reported: PAIN IN EXTREMITY (non-serious) with onset 2021, outcome "unknown", described as "arm hurt"; VACCINATION SITE PAIN (non-serious) with onset 2021, outcome "unknown", described as "arm hurt right away and then hurt for 2 years at injection site"; HEADACHE (non-serious) with onset 19Jul2021, outcome "unknown"; HYPERTENSION (medically significant) with onset 20Jul2021, outcome "unknown"; ISCHAEMIC STROKE (hospitalization, medically significant) with onset 20Jul2021, outcome "unknown", described as "this occurred on 20Jul2021, it was an ischemic stroke"; VASCULAR DEMENTIA (medically significant) with onset 13Aug2022, outcome "unknown", described as "Caller states that because of the stroke, her husband also has vascular dementia". The patient was hospitalized for ischaemic stroke (start date: 20Jul2021, discharge date: 22Jul2021, hospitalization duration: 3 day(s)). Therapeutic measures were taken as a result of hypertension, headache.   Clinical Course: Caller states that they do not want to provide HCP information at this time. The caller's husband then comes onto the line and states that the first doctor he had didn't do anything. They blamed his symptoms on other things, but the second doctor questioned it. Caller's husband states that he had a heart catheter a year before this and had perfect veins, great veins for a 48-year-old, as he was 48 at the time. The caller reports that her husband had the Pfizer COVID 19 Vaccine, first dose of the primary series and then 6 months later he had a stroke. The caller also reports that right after her husband received the first dose of the primary series of the vaccine his arm hurt right away at the injection site and continued to hurt for 2 years. Caller's husband states that the first doctor he had kept writing it up as arthritis in the shoulder. Now he has a new doctor and Doctor # questions the shot. No further information provided related to doctor #, name documented as provided, but not spelled, by the caller's husband. The old neurologist said that there was no way it could be the COVID shot, it has to be diabetes or something that caused the stroke. Before all of this the caller's husband states that he had no high blood pressure or anything. Caller states that this occurred on 20Jul2021, it was an ischemic stroke. Hospitalization: Caller and her husband state that the husband went into the hospital the day before 20Jul2021 and was given some medication and sent home with them saying he had a headache. The next day, 20Jul2021, he found out it was a stroke and was hospitalized for like three days. Caller mentions that her husband was in 2 different hospitals. Caller denies any concomitant medications, states that her husband has been placed on unspecified blood pressure medication, but that was after the vaccine, before the vaccine he was not on blood pressure medication. Caller states that the doctor says they have to watch her husband's blood pressure because he knows has hypertension, he never had it before. Diagnosed with hypertension on 20Jul2021. Caller states that they were checking her husband for a-fib because it runs in his family. They did a heart catheter, and everything was normal, this was just a year prior to the stroke. Again, the caller's husband states that he was told he had the best veins for a 48-year-old man. Caller and her husband state that this was almost a year to the day prior to the stroke, the catheter was in Jul2020 or Aug2020. Caller states that because of the stroke, her husband also has vascular dementia. They knew something was wrong prior to his vascular dementia diagnosis on 13Aug2022. Caller states that they just wanted to make sure that this is recorded and is why her husband had the stroke. Caller's husband states that he thinks a member of congress had the same stroke. States also that he met 4 people when he worked at # who got the shot and then had a stroke afterwards, one person died. Attempted to clarify if these people received the Pfizer vaccine as the caller initially stated and then stated no, caller says that he has no details related to these events, it is unknown what vaccine these people that the caller's husband spoke of received. Sender's Comments: Linked Report(s): US-PFIZER INC-202300068974 Same patient/vaccine, different dose/event;