very nauseous; vomiting; fever; very fatigued; bloody mucus from my nasal; much worse with my sinuses, chest and eyes being most affected; much worse with my sinuses, chest and eyes being most affected; much worse with my sinuses, chest and eyes being most affected; aggravated especially the lupus; aggravated especially the Sjogrens; aggravated especially the Sjogrens; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP) from medical information team. The reporter is the patient.  A 64-year-old female patient (not pregnant) received BNT162b2 (BNT162B2), on 28Aug2021 as dose 3 (booster), single (Lot number: FC3184) at the age of 64 years, in right arm for covid-19 immunisation. The patient's relevant medical history included: "known allergies: penicillin" (unspecified if ongoing); "Lupus" (ongoing), notes: Lupus; "Sjogrens" (ongoing); "Rheumatoid arthritis" (ongoing). Concomitant medication(s) included: METHOTREXATE. Vaccination history included: BNT162b2 (Dose Number: 1, Batch/Lot No: EN6203, Location of injection: Arm Right), administration date: 20Mar2021, when the patient was 63-year-old, for COVID-19 Immunization; BNT162b2 (Dose Number: 2, Batch/Lot No: EW0158 , Location of injection: Arm Right), administration date: 10Apr2021, when the patient was 63-year-old, for COVID-19 Immunization, reaction(s): "bloody mucus from my nasal", "very nauseous", "Vomiting", "Fever", "very fatigued". The following information was reported: SJOGREN'S SYNDROME (disability), CONDITION AGGRAVATED (disability) all with onset 29Aug2021, outcome "recovered with sequelae" and all described as "aggravated especially the Sjogrens"; SYSTEMIC LUPUS ERYTHEMATOSUS (disability) with onset 29Aug2021, outcome "recovered with sequelae", described as "aggravated especially the lupus"; EPISTAXIS (disability) with onset 29Aug2021, outcome "recovered with sequelae", described as "bloody mucus from my nasal"; PYREXIA (disability) with onset 29Aug2021, outcome "recovered with sequelae", described as "fever"; SINUS DISORDER (disability), CHEST DISCOMFORT (disability), EYE DISORDER (disability) all with onset 29Aug2021, outcome "recovered with sequelae" and all described as "much worse with my sinuses, chest and eyes being most affected"; FATIGUE (disability) with onset 29Aug2021, outcome "recovered with sequelae", described as "very fatigued"; NAUSEA (disability) with onset 29Aug2021, outcome "recovered with sequelae", described as "very nauseous"; VOMITING (disability) with onset 29Aug2021, outcome "recovered with sequelae". The events "very nauseous", "vomiting", "fever", "very fatigued", "bloody mucus from my nasal", "much worse with my sinuses, chest and eyes being most affected", "aggravated especially the lupus" and "aggravated especially the sjogrens" required physician office visit. Therapeutic measures were taken as a result of nausea, vomiting, pyrexia, fatigue, epistaxis, sinus disorder, chest discomfort, eye disorder, systemic lupus erythematosus, sjogren's syndrome, condition aggravated.  Clinical course: The patient had no other vaccine in four weeks. The patient had no COVID prior vaccination. COVID was not tested post vaccination. The patient stated, "With my 2nd shot, was very nauseous, vomiting, fever, very fatigued, bloody mucus from my nasal. this lasted 10 days. With the booster, I had the same symptoms, but much worse with my sinuses, chest and eyes being most affected. This lasted 6 plus months and I never fully recovered. I have Lupus, Sjogrens and rheumatoid arthritis. I felt that the vaccine aggravated especially the lupus and Sjogrens. Now I have the problem of not being able to take the 2nd booster, so am not properly protected." AE Treatment: put on steroid and nebulizer.