feeling as if he had a 2nd degree burn; skin coming off; water running down the compromised burn; legs extremely sore to the/finger touching the area; injection was very painful; Injection site was red; Heat Rash; fluid build up/ swelling on the back of his legs; extreme pain in leg; Pain; Leg rash / rash sore to the touch; This case was reported by a consumer via call center representative and described the occurrence of injection site pain in a 56-year-old male patient who received Herpes zoster (Shingrix) for prophylaxis.   Previously administered products included Shingles (Last shingles vaccine received in 2015). Concurrent medical conditions included back disorder, psoriasis, difficulty breathing and increased skin sensitivity (Skin hypersensitivity). Concomitant products included fluticasone furoate, vilanterol trifenatate (Breo Ellipta), tiotropium bromide (Spiriva Respimat), atorvastatin calcium (Lipitor), alprazolam (Xanax), oxycodone, valaciclovir hydrochloride (Valtrex), vitamins nos (Multivitamin), ulobetasol (Halobetasol Cream) and oxygen.   On 10th February 2020, the patient received the 1st dose of Shingrix (intramuscular). On 10th February 2020, less than a day after receiving Shingrix, the patient experienced injection site pain, injection site erythema, heat rash, swelling of legs and leg pain. On 12th February 2020, the patient experienced burning sensation, skin desquamation, wound oozing and tenderness. In February 2020, the patient experienced pain and rash. The patient was treated with benadryl (nos) (Benadryl). On an unknown date, the outcome of the injection site pain, injection site erythema, heat rash, swelling of legs and leg pain were not recovered/not resolved and the outcome of the pain and rash were recovering/resolving and the outcome of the burning sensation, skin desquamation, wound oozing and tenderness were unknown.   It was unknown if the reporter considered the injection site pain, injection site erythema, heat rash, swelling of legs, leg pain, pain, burning sensation, skin desquamation, wound oozing, rash and tenderness to be related to Shingrix.  Additional details were provided as follows: The age at vaccination was not reported. On 10th February 2020 11.30 AM, the patient received Shingrix in left arm. The patient experienced very painful injection site and injection site red. In the evening after injection he noticed a heat rash and fluid build up or swelling on the back of his legs behind knee caps but more noticeably on the back of his right leg.  On 11th February 2020, the consumer reported that the rash and other symptoms still present and ensured he kept Benadryl nearby in the event of an allergic reaction.  On 12th February 2020 around 9PM, reported that the swelling decreased quite a bit, but experienced rash behind legs extremely sore to the touch. The reporter described simply finger touching the area caused extreme pain in leg.  The reporter also reported taking a shower that night and describes pain as feeling as if he had a 2nd degree burn, skin coming off, and water running down the compromised burn On 13th February 2020, the pain and redness slightly present. The patient believed that if he takes a shower that the pain would not be that bad because his pants leg touching was not as painful currently as it was before. The leg rash and pain was subsiding. The reporter consented to follow up