Patient stated they were itching; Diagnosed with diabetes; blood pressure of 192/93; breaking out that she describe it as chicken pox.The chicken pox break out were in the warm area like under arm and on the stomach.break out did not stop and spread through out the body except for face and feet; diagnosis with dermatitis; biopsy and it was done from the bump that was on the arm; pain in the chest,experienced the chest pain again; left arm went numb and tingling; left arm went numb and tingling; weird feeling; diagnosed with a heart attack; throat was closing up; patient felt nauseated,patient experienced nausea; This spontaneous case was reported by a consumer and describes the occurrence of VARICELLA, DERMATITIS, PERIPHERAL SWELLING, CHEST PAIN, HYPOAESTHESIA, PARAESTHESIA, FEELING ABNORMAL, MYOCARDIAL INFARCTION, OROPHARYNGEAL DISCOMFORT, NAUSEA, PRURITUS, DIABETES MELLITUS, and HYPERTENSION (blood pressure of 192/93) in a 49-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch no. 035C21A) for COVID-19 vaccination.     The patient's past medical history included Chickenpox and Stent placement (Patient was discharged from the hospital on 30Sep2021) on 28-Sep-2021. Concurrent medical conditions included Migraine. Concomitant products included CLONAZEPAM for Anxiety, PAXIL for Depression, FIORICET for Migraine, ASPIRIN, LIPITOR, LISINOPRIL, METOPROLOL, BRILINTA, and WELLBUTRIN XL for an unknown indication.    On 14-May-2021, the patient received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 28-Sep-2021, the patient experienced CHEST PAIN (seriousness criteria hospitalization prolonged and medically significant). 28-Sep-2021, the patient experienced HYPOAESTHESIA (seriousness criteria hospitalization prolonged and medically significant), PARAESTHESIA (seriousness criteria hospitalization prolonged and medically significant), FEELING ABNORMAL (seriousness criteria hospitalization prolonged and medically significant), MYOCARDIAL INFARCTION (seriousness criteria hospitalization prolonged and medically significant), OROPHARYNGEAL DISCOMFORT (seriousness criteria hospitalization prolonged and medically significant), NAUSEA (seriousness criteria hospitalization prolonged and medically significant) and HYPERTENSION (blood pressure of 192/93) (seriousness criteria hospitalization and medically significant). On an unknown date, the patient experienced VARICELLA (seriousness criterion medically significant), DERMATITIS (seriousness criterion medically significant), PERIPHERAL SWELLING (seriousness criterion medically significant), PRURITUS (seriousness criterion hospitalization), and DIABETES MELLITUS (seriousness criteria hospitalization and medically significant). The patient was treated with PREDNISONE for Dermatitis, at a dose of 10 milligram, 4 milligram dose pak for 6 days; HYDROXYZINE for Itching, at a dose of 25 milligram; CEFALEXIN for Adverse event, at a dose of 25 milligram; TRIAMCINOLONE for Adverse event, at a dose of 0.1% (450 grams); VALTREX for Adverse event, at an unspecified dose and frequency; NURTEC for Migraine, at an unspecified dose and frequency; ASPIRIN for Adverse event, at an unspecified dose and frequency and NITRO for Adverse event, at an unspecified dose and frequency. On 30-Sep-2021, CHEST PAIN, HYPOAESTHESIA, PARAESTHESIA, FEELING ABNORMAL, MYOCARDIAL INFARCTION, OROPHARYNGEAL DISCOMFORT, NAUSEA, and HYPERTENSION (blood pressure of 192/93) had resolved. At the time of the report, VARICELLA had not resolved and DERMATITIS, PERIPHERAL SWELLING, PRURITUS, and DIABETES MELLITUS outcome was unknown.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available) on 28-May-2021, Blood cholesterol 202 (High), Recovered on 28-Sep-2021. On an unknown date, Blood pressure measurement 192/93 (High) and 188/84 (High). On an unknown date, Electrocardiogram (abnormal), sign of heart attack.         Post vaccination, It was reported that biopsy was done from the bump that was on the arm and leg and the result from biopsy showed that those bumps are related to medicine. Patient had a cold patch on the back due to the intense pain.  Company Comment: This case concerns a 49-year-old, female patient with medical history of Chickenpox, concomitant use of NURTEC, CLONAZEPAM, WELLBUTRIN, FIORICET, LIPITOR, METOPROLOL, ASPIRIN, BRILINTA, and PAXIL who experienced the unexpected serious events of varicella, dermatitis, peripheral swelling, chest pain, hypoaesthesia, paraesthesia, feeling abnormal, myocardial infarction, oropharyngeal discomfort, nausea, pruritus, diabetes mellitus, and hypertension. The events occurred unknown number of days after the second dose of mRNA-1273 vaccine administration. The rechallenge was not applicable, as the events occurred after the second dose and no additional dose is expected. The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report.