Second Dose: Weight Loss and Couldn't Eat Anything; Second Dose: Diarrhea; he had intestinal problems and he couldn't eat.; Second Dose: dehydrated because couldn't eat and all levels were off; Second Dose: Reaction, Body Rejected the Vaccine and caused inflammation in his body; Second Dose: Blood Clots in Lungs and Legs with Retrieval; legs swollen up big, low oxygen levels; Second Dose: Blood Clots in Lungs and Legs with Retrieval; legs swollen up big, low oxygen levels; Second Dose: Coded at Home and needed CPR/he couldn't breathe; Second Dose: Weight Loss and Couldn't Eat Anything; Second Dose: Very Anemic and Iron Deficiency Really Bad; Second Dose: Very Anemic and Iron Deficiency Really Bad; Second Dose: Left Leg Pain from Blood Clots; every time he would stand up, his heart would race so he couldn't walk; from blood clots; every time he would stand up, his heart would race so he couldn't walk; from blood clots; Second Dose: Hair Loss; Second Dose: couldn't use the bathroom to have a BM; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP), Program ID: (002591). The reporter is the patient.  A 49-year-old male patient received BNT162b2 (BNT162B2), on 13May2021 as dose 2, single (Lot number: ER8734) at the age of 48 years, in left arm for covid-19 immunisation. The patient's family history included: "Chron's with Hereditary Alpha Tryptasemia" (unspecified if ongoing). The patient's concomitant medications were not reported. Vaccination history included: BNT162b2 (DOSE 1, SINGLE Lot: ER6207), administration date: 09Apr2021, when the patient was 48-year-old, for Covid-19 immunization, reaction(s): "he felt tired a lot", "First Dose: didn't feel right and didn't feel well". The following information was reported: DECREASED APPETITE (hospitalization), WEIGHT DECREASED (non-serious), outcome "recovering" and all described as "Second Dose: Weight Loss and Couldn't Eat Anything"; INFLAMMATION (hospitalization) with onset May2021, outcome "recovering", described as "Second Dose: Reaction, Body Rejected the Vaccine and caused inflammation in his body"; DYSPNOEA (life threatening), outcome "recovered", described as "Second Dose: Coded at Home and needed CPR/he couldn't breathe"; THROMBOSIS (hospitalization), OXYGEN CONSUMPTION DECREASED (hospitalization), outcome "recovering" and all described as "Second Dose: Blood Clots in Lungs and Legs with Retrieval; legs swollen up big, low oxygen levels"; DIARRHOEA (hospitalization), outcome "recovering", described as "Second Dose: Diarrhea"; GASTROINTESTINAL DISORDER (hospitalization), outcome "unknown", described as "he had intestinal problems and he couldn't eat."; DEHYDRATION (hospitalization), outcome "recovered", described as "Second Dose: dehydrated because couldn't eat and all levels were off"; IRON DEFICIENCY (non-serious), ANAEMIA (non-serious), outcome "recovering" and all described as "Second Dose: Very Anemic and Iron Deficiency Really Bad"; PAIN IN EXTREMITY (non-serious), outcome "recovering", described as "Second Dose: Left Leg Pain from Blood Clots"; HEART RATE INCREASED (non-serious), GAIT DISTURBANCE (non-serious), outcome "recovered" and all described as "every time he would stand up, his heart would race so he couldn't walk; from blood clots"; ALOPECIA (non-serious), outcome "recovering", described as "Second Dose: Hair Loss"; BOWEL MOVEMENT IRREGULARITY (non-serious), outcome "recovered", described as "Second Dose: couldn't use the bathroom to have a BM". The patient was hospitalized for thrombosis, oxygen consumption decreased (hospitalization duration: 5 day(s)). The events "second dose: coded at home and needed cpr/he couldn't breathe", "second dose: reaction, body rejected the vaccine and caused inflammation in his body", "second dose: blood clots in lungs and legs with retrieval; legs swollen up big, low oxygen levels", "he had intestinal problems and he couldn't eat.", "second dose: dehydrated because couldn't eat and all levels were off", "second dose: weight loss and couldn't eat anything", "second dose: very anemic and iron deficiency really bad", "second dose: left leg pain from blood clots", "every time he would stand up, his heart would race so he couldn't walk; from blood clots", "second dose: hair loss" and "second dose: couldn't use the bathroom to have a bm" required physician office visit and emergency room visit. The patient underwent the following laboratory tests and procedures: Anaemia: Very Anemic; Biopsy bone marrow: Unknown results; Heart rate: increase; Iron deficiency: Iron Deficiency Really Bad; Weight: Decreased. Therapeutic measures were taken as a result of dyspnoea, inflammation, thrombosis, oxygen consumption decreased, decreased appetite, diarrhoea, gastrointestinal disorder, dehydration, weight decreased, pain in extremity, heart rate increased, gait disturbance, alopecia, bowel movement irregularity.  Clinical Information:Reporter stated she had a patient on the line that has been taking Xeljanz XR 11mg. The reporter informed he was in the hospital because he has Crohn's Disease with Hereditary Alpha Tryptasemia and when he took the Pfizer Covid Vaccine it caused a reaction and his body rejected the vaccine. (Name withheld) stated the patient reports he lost a lot of weight, lost muscle in his legs and he couldn't walk, he was in the hospital twice, and he also coded at home 2 times. he went to rehabilitation and stated he couldn't breathe when he was there and they discovered he had a lot of blood clots in his lungs and a lot in his legs. Reporter reports he had intestinal problems and he couldn't eat. Reporter stated all of this started in Jul2021. the Xeljanz is helping. he had lost his hair from the vaccine reaction and now some is growing back due to Xeljanz.  Ran out of Medication Xeljanz XR. he started taking Xeljanz XR 11mg on 14Apr2022 after the Covid 19 Vaccine reaction as a treatment for Crohn's and was out of the medication for 2 weeks; however the nurse called yesterday and she found another sample bottle for him so he picked that up yesterday. the Xeljanz made him feel better and it made some of his hair grow back. the doctor gave him a 30 day supply and he took it every day so he ran out on 15May2022 until he got more on 02Jun2022. NDC, Lot, Expiration: Unknown. he doesn't have that bottle with him.  The Second Dose was the one when all hell broke lose. He couldn't eat and had diarrhea. He went in the hospital and they ran all of the tests, even a bone marrow test and it didn't come back as anything. He coded and his nephew was there and did CPR on him and brought him back. Reporter stated every time he would stand up, his heart would race so he couldn't walk. His family put him in a rehab facility so he could get his strength back and go home. The whole time he was in there, he couldn't walk because every time he would stand up, his heart would race. it turns out it was blood clots, a lot of them. He had to have a retrieval done. Also stated he found out he has Crohn's with HATs and his doctor only has 9 patients with that and he is the second patient that the vaccine triggered a reaction with. His body thought the vaccine was a foreign object so his body was rejecting it and it caused inflammation in his body. He wasn't walking either, because there were so many blood clots in his lungs and both legs and still in his left leg and it causes pain. They treated the main blood clots. Reporter stated he has a friend who is a funeral director and embalmer, and he told him he has only seen that many in dead people because so many blood clots had come out of his lungs. It all started with the Covid 19 Vaccine and he can't take anymore vaccines. The only other one he can get is the Shingles vaccine but he is scared to take any vaccines. The whole time he was in Rehab for 3 months, he couldn't use the bathroom to have a BM and when he got home, the Xeljanz helped him to go to the bathroom, maybe because it decreased inflammation. He first went to the ER 4 days in a row because he was dehydrated because couldn't eat and all levels off. They didn't keep him but they wanted to because they were full at the time already with patients so he had to keep going back. That was in July and Aug2021. On 18Sep2021 or 19Sep2021 he went into the rehab facility for help getting back going, kept telling them something was wrong, his legs were swollen up big, and then he had an episode were his oxygen level was low and he couldn't breathe so they admitted him to the hospital for the blood clots. That was in Nov2021 a week or two before the holidays. He still has a blood clot in his left leg and they are treating it with blood thinners and they said he will be on blood thinners for the rest of his life. He has a lot of leg pain.; Sender's Comments: Linked Report(s) : US-PFIZER INC-202200803458 Same pt/drug, diff event sep in time