Tested positive for syphilis; This is a spontaneous report from a contactable consumer (patient) via medical information team. This male consumer (patient) reported for himself.  A male patient of an unspecified age received second dose of BNT162B2 (COMIRNATY; solution for injection, Lot Number: not reported, Expiry date: not reported) via an unspecified route of administration, on 20Apr2021 as dose 2, single for COVID-19 immunization. Medical history included pneumonia from an unknown date and unknown if ongoing (maybe he had pneumonia some time along). The patient concomitant medications were not reported. The patient previously took first dose of BNT162B2 (COMIRNATY; solution for injection, Lot Number: not reported, Expiry date: not reported) via an unspecified route of administration, on an unspecified date as dose 1, single for COVID-19 immunization. On an unspecified date in 2021, the patient tested positive for syphilis. It was reported that patient received his second dose of the Pfizer BioNtech covid 19 vaccines on 20Apr2021 shortly after he donated blood as he has done for the past 10 to 15 years. He received a notification in the mail tested positive for syphilis, however his follow up syphilis test was negative. This past month patient donated blood again and received the same positive syphilis test result therefore he is no longer eligible to donate blood. Patient states that the donation agency said they have seen spike in this happening with vaccination. Patient seeking information as to why this may be happening. Patient states he received a notification in the mail after blood donation stating that he tested positive on their blood screening test results, he has never tested positive for anything before. Says he tested positive on the pre-screening for Syphilis, MHA-TP test. He called the blood donation place and they said it was a pre-screening test and the follow up Syphilis GE1A test was negative. He told them that he had recently gotten the Covid Vaccine. They said maybe it was something to do with his antibodies and it is showing up in the test. Patient states that he donated blood again this past month and got the same test results. This time they told him he is no longer eligible to donate blood. He called the blood donation place again to ask more questions and they told him they don't know what is going on. They told him that since people started getting the vaccine, they have seen a spike in test results like his. He has looked into what else could cause a positive on this test. He said he read that recent pneumonia, tuberculosis or HIV infection could cause positive readings. Caller states when he thinks of those illnesses, he thinks they are very severe, if it was just him it had happened to, he would've figured it may be something weird; like maybe he had pneumonia some time along. Since the blood donation place said they've seen a spike in positive results and are not able to use people's blood he is more concerned. States that he has been donating blood for 10-15 years and has never had anything come back positive until this test about a month after the vaccine. On an unspecified date in 2021, the patient underwent lab tests and procedures which included treponema test: negative, treponema test: positive, treponema test: positive, treponema test: negative, treponema test: positive. The clinical outcome of the event was unknown.  The lot number for the vaccine, [BNT162B2], was not provided and will be requested during follow up.