He got a rash on both arms again , but didn't have pain/ big rash on his left arm where he got the shot, and a small rash on his right arm; Booster; His connective tissue disease flared up; His connective tissue disease flared up; He had worse pain and a big rash on the left arm (injection arm). He also had a sympathetic rash and pain on his right arm./ rash and pain in both arms; He had worse pain and a big rash on the left arm (injection arm). He also had a sympathetic rash and pain on his right arm.; The booster raised his immunity again/ It took his immune system to 110%./ it increased antibodies.; This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP) from medical information team. The reporter is the patient.  A 73 year-old male patient received bnt162b2 (BNT162B2), administered in arm left, administration date 20Aug2021 (Lot number: EW0196) at the age of 73 years as dose 3 (booster), single for covid-19 immunisation. Relevant medical history included: "connective tissue disease" (ongoing), notes: Verbatim: connective tissue disease, He has an autoimmune problem with a Connective tissue disease. Family history included: "auto immune problems" (unspecified if ongoing), notes: His mom had a lot of auto immune problems; "scleroderma" (unspecified if ongoing), notes: The connective tissue disease doesn't have a name. It is part of a family disease like scleroderma or something. His mom had a lot of auto immune problems. He feels like he got it from her. Concomitant medication(s) included: COLCHICINE taken for connective tissue disorder (ongoing). Vaccination history included: Bnt162b2 (First Dose, lot number: EH9899, Anatomical location: left arm), administration date: 05Jan2021, when the patient was 73 years old, for Covid-19 Immunization, reaction(s): "had a rash and pain in both arms", "Pain in both arms"; Bnt162b2 (Second Dose, lot number: EI9262, Anatomical location: left arm), administration date: 26Jan2021, when the patient was 73 years old, for Covid-19 Immunization, reaction(s): "had a rash and pain in both arms", "Pain in both arms". The following information was reported: IMMUNISATION (non-serious) with onset 20Aug2021, outcome "unknown", described as "Booster"; CONNECTIVE TISSUE DISORDER (non-serious), CONDITION AGGRAVATED (non-serious) all with onset 2021, outcome "not recovered" and all described as "His connective tissue disease flared up"; RASH (non-serious) with onset 2021, outcome "recovered" (2021), described as "He had worse pain and a big rash on the left arm (injection arm). He also had a sympathetic rash and pain on his right arm./ rash and pain in both arms"; PAIN IN EXTREMITY (non-serious) with onset 2021, outcome "recovered" (2021), described as "He had worse pain and a big rash on the left arm (injection arm). He also had a sympathetic rash and pain on his right arm."; IMMUNE SYSTEM DISORDER (non-serious) with onset 2021, outcome "unknown", described as "The booster raised his immunity again/ It took his immune system to 110%./ it increased antibodies."; RASH (non-serious) with onset Dec2021, outcome "recovered" (Dec2021), described as "He got a rash on both arms again , but didn't have pain/ big rash on his left arm where he got the shot, and a small rash on his right arm". The events "his connective tissue disease flared up", "his connective tissue disease flared up", "he had worse pain and a big rash on the left arm (injection arm). he also had a sympathetic rash and pain on his right arm./ rash and pain in both arms", "he had worse pain and a big rash on the left arm (injection arm). he also had a sympathetic rash and pain on his right arm.", "the booster raised his immunity again/ it took his immune system to 110%./ it increased antibodies." and "he got a rash on both arms again , but didn't have pain/ big rash on his left arm where he got the shot, and a small rash on his right arm" were evaluated at the physician office visit.  Additional Information: Additional vaccine administered on same day was reported as none. Prior vaccinations within 4 weeks were reported as none. It was reported that He went back in Aug2021 and got his COVID booster. He got the same side effects as the first vaccine. He had worse pain and a big rash on the left arm (injection arm). He also had a sympathetic rash and pain on his right arm. They have went away. He has an autoimmune problem with a Connective tissue disease. It has been under control since the doctor put him on Colchicine, 0.6mg one tablet per day. That product has not only stopped tissue from growing but reversed it. Caller doesn't have NDC/lot/expiration. Everything has been fine, until he took the booster and things went haywire. The booster raised his immunity again. Somehow the booster set off his connective tissue disease, and now it is out of control. Then, this past Saturday, almost 4 months after the booster, he got a rash in the exact same place that he had gotten when he got the shot.  He got a rash on both arms again but didn't have pain. He had a big rash on his left arm where he got the shot, and a small rash on his right arm. The rash went away in a couple days. Until it came back 4 months later. It was there two days and went down.  No follow-up attempts are possible. No further information is expected.