This spontaneous case was reported by an other health care professional and describes the occurrence of URTICARIA (started breaking out in hives/the hives end up spreading out even more/hives breaking out on her face and jawline), PRURITUS (Itching on shoulders/All those areas are very itchy), SCRATCH (She scratches those areas, the rashes swells up), SWELLING (The rashes swell up) and RASH (The rashes are mainly on her upper body and sometimes show up in her legs as well/she has noticed it mainly in the shoulder area and her back) in a 22-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 045J21A, 026Z20A and 030L20A) for COVID-19 vaccination. Concomitant products included VITAMIN B12 NOS and ELDERBERRY [SAMBUCUS NIGRA] for an unknown indication. On 07-Jan-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. On 29-Dec-2021, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On an unknown date, the patient received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 11-Jan-2022, the patient experienced URTICARIA (started breaking out in hives/the hives end up spreading out even more/hives breaking out on her face and jawline), PRURITUS (Itching on shoulders/All those areas are very itchy), SCRATCH (She scratches those areas, the rashes swells up) and RASH (The rashes are mainly on her upper body and sometimes show up in her legs as well/she has noticed it mainly in the shoulder area and her back). On an unknown date, the patient experienced SWELLING (The rashes swell up). The patient was treated with DIPHENHYDRAMINE HYDROCHLORIDE (BENADRYL [DIPHENHYDRAMINE HYDROCHLORIDE]) for Adverse event, at an unspecified dose and frequency and CETIRIZINE HYDROCHLORIDE (ZYRTEC ALLERGY) for Adverse event, at an unspecified dose and frequency. At the time of the report, URTICARIA (started breaking out in hives/the hives end up spreading out even more/hives breaking out on her face and jawline), PRURITUS (Itching on shoulders/All those areas are very itchy), SCRATCH (She scratches those areas, the rashes swells up), SWELLING (The rashes swell up) and RASH (The rashes are mainly on her upper body and sometimes show up in her legs as well/she has noticed it mainly in the shoulder area and her back.) had not resolved. For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown), the reporter did not provide any causality assessments. Concomitant medication also included birth control pills. The patient had no known allergies. The patient was a nursing assistant as well as a student at the nursing school. Approximately 2 weeks after receiving the booster dose, on 11 Jan 2022, she started experiencing itching on her shoulders. She noticed that she had started breaking out in hives. She said that it had gone on a lot longer that she had thought it would. She had not made any other lifestyle changes in these last few weeks. There have been no changes in her day-to-day routine that could have caused these hives. She said that the rashes were mainly on her upper body and sometimes showed up in her legs as well. However, she had noticed it mainly in the shoulder area and her back. She stated that when she scratched those areas, the rashes swelled up and the hives ended up spreading out even more. She had also noticed the hives breaking out on her face and jawline. All those areas are very itchy. This case was linked to MOD-2022-461855 (Patient Link).