URTICARIAL NODULAR RASH/ THIRD RASH ON THE BACK OF HEAD ABOVE HAIRLINE  THAT WENT DOWN TO SCALP, NECK AND UPPER BACK; HAD INCREASED OF USE  INHALER; LIGHTHEADED; ITCHINESS/ GENERALIZED ITCHING; RASH ON LEFT SIDE OF HEAD, LEFT SIDE OF NECK AND WAS SLIGHTLY BURNING; ITCHY RASH DOWN THE SIDE OF HEAD TO FACE; HIVES; This spontaneous report received from a health care professional (husband of patient) concerned a 76 year old white female of unspecified ethnicity. The patient's height, and weight were not reported. No past medical history or concurrent conditions were reported. On 03-APR-2021, the patient  received covid-19 vaccine ad26.cov2.s (Dose number in series 1) (suspension for injection, route of admin not reported, batch number: 1808978, expiry: 11-SEP-2021), dose was not reported, 1 total administered possibly to left arm for prophylactic vaccination.  On an unspecified date following vaccination with covid-19 vaccine ad26.cov2.s the patient experienced itchiness and had increased use of asthma inhaler. (Dose number in series 1). The outcome for itchiness and had increased use of asthma inhaler was not reported. The patient received covid-19 vaccine ad26.cov2.s (Dose number in series 2) (suspension for injection, route of admin not reported, and batch number: 1822811 expiry: 20-MAR-2022) dose was not reported, 1 total  administered on 02-NOV-2021 for prophylactic vaccination. No concomitant medications were reported.  On an unspecified date in NOV-2021, 2 weeks after vaccination with covid-19 vaccine ad26.cov2.s, the patient experienced rash on left side of head that  started as hives. It was itchy (itchy rash) and went down the side of head to face. It was resolved after about a week. A few weeks later the patient experienced a second rash on the left side of neck that was itchy and slightly burning. It resolved about a week later. The patient also had increased use her asthma inhaler. The patient  felt lightheaded after the booster and had to lay down. On an unspecified date, the patient recently had a third rash on the back of head above hairline that went down to scalp, neck and upper back, which was an urticarial nodular rash (hives). It had markedly improved after a week, as the patient administered her normal dose of Loratadine 5mg with 25 mg Benadryl for 2 nights combined with taking 50mg of prednisone on the first night and taking 20 mg of prednisone on second night. The patient had administered Benadryl and Prednisone approximately 5 days after the start of the rash. It was reported that all three rashes caused generalized itching and burning and that the second and third rashes were mild.  (Dose number in series 2) The action taken with covid-19 vaccine ad26.cov2.s was not applicable. The patient recovered from itchy rash on left side of head to face, rash on left side of neck that was itchy and slightly burning, was recovering from urticarial nodular rash/ third rash on the back of head above hairline that went down to scalp, neck and upper back, and the outcome lightheaded, hives and itchiness/ generalized itching, and increased use of inhaler was not reported. This report was non-serious. This case, involving the same patient is linked to 20210421326 (dose number in series 1).