center of his palm was itching on his left hand; tops of his feet itched like crazy and the base of his toes and different parts of his body were itching but the skin only turned red a little bit from him scratching where it was itching; he felt his elbows and the back of his knees and his arm, anywhere there was skin to skin contact or hot, started feeling crazy and it was itching; had patches of red under each armpit, on his elbows and on his knees as well with raised bumps that were coming up; He got the Johnson and Johnson shot, clarified to the Johnson and Johnson COVID vaccine, on 07Mar2021; He got the Johnson and Johnson shot, clarified to the Johnson and Johnson COVID vaccine, on 07Mar2021; This is a spontaneous report from a contactable consumer (patient). A 48-years-old male patient received bnt162b2 (PFIZER-BIONTECH COVID-19 mRNA VACCINE, Solution for injection, Batch/Lot Number: FF3590) via an unspecified route of administration on 07Nov2021 at 10:20 as dose 2 (booster), single for COVID-19 immunization. Medical history included 360 spinal fusion from 2014 to an unknown date. Concomitant medications included influenza vaccine (FLU VACCINE VII) taken for an unspecified indication from 03Nov2021 to 03Nov2021; hepatitis a vaccine inact, hepatitis b vaccine rhbsag (yeast) (TWINRIX) taken for an unspecified indication from 03Nov2021 to 03Nov2021; omeprazole (OMEPRAZOLE) taken for dyspepsia; tadalafil (TADALAFIL) taken for spinal fusion surgery. Historical vaccine included Johnson and Johnson COVID vaccine (COVID-19 VACCINE JANSSEN, Batch/Lot Number: 1802072) via an unspecified route of administration on 07Mar2021 as dose 1, single for COVID-19 immunisation. On 08Nov2021 the patient experienced center of his palm was itching on his left hand, tops of his feet itched like crazy and the base of his toes and different parts of his body were itching but the skin only turned red a little bit from him scratching where it was itching, he felt his elbows and the back of his knees and his arm, anywhere there was skin to skin contact or hot, started feeling crazy and it was itching, had patches of red under each armpit, on his elbows and on his knees as well with raised bumps that were coming up. He got the johnson and johnson shot, clarified to the johnson and johnson covid vaccine, on 07mar2021. It was reported that on his right arm and it excessively itches. Then, previously, after the left palm itching, the tops of his feet itched like crazy and the base of his toes and different parts of his body were itching but the skin only turned red a little bit from him scratching where it was itching. It was reported that he went back to sleep and said that he would deal with it because he had no Benadryl or hydrocortisone cream. So he went back to sleep and when he woke up he went to work and was wearing normal clothes and he was itching some but it wasn't really a bother. It was reported that after dinner during that he felt his elbows and the back of his knees and his arm, anywhere there was skin to skin contact or hot, started feeling crazy and it was itching came on so he went straight to and went to the pharmacy and said that he was itching like crazy and they said to get the hydrocortisone cream and Benadryl so he took 2 Benadryl and rubbed the hydrocortisone cream on and took pictures of what it looked like. He had patches of red under each armpit, on his elbows and on his knees as well with raised bumps that were coming up. He had stripped down and laid down to cool down and sit there. He doesn't think that he had a fever. It was reported that after he took the Benadryl, his whole body was in raised bumps and red, his neck had splotches but his face didn't, and both arms had splotches, the tops of his arms didn't have the bumps they were all on the underside, his entire leg down to his knee had them and little behind it, they were all on his back and his butt and both sides had turned red and his hips had raised whelps on them. Because of all that he had taken he was told that he needed to get to the emergency room. They were concerned in the emergency room and baffled because they had not seen anyone react this way. They had asked about his eating habits for the last two days to be sure that he didn't have a food allergy and then they gave him an IV that had no bag it was just used to connect shots to it. They gave him diluted steroids and diluted Benadryl and right now the center of his palm is bright red and he thinks that he is about to go through this again and again the itching is crazy, like poison ivy itching. He had attempted to look through his paperwork from the emergency room to find the amounts for the medications that he had received while there and he says that he doesn't see where they are listed at on there. He is not mad about this he just doesn't want it to happen again. On his paperwork they had called what he had hives and he doesn't see what they did listed on there but he tell he was he doesn't see what mg of what they had gave him. They must've done something to check him out and maybe he just didn't get that but he was treated for hives, at least that is what he understood. It was reported that he has already taken 2 benadryl and he has to go get his prescription for the steroids. The patient underwent lab tests and procedures which included heart rate: 78 beats per minute on unknown date in Nov2021. Therapeutic measures were taken as a result of center of his palm was itching on his left hand (pruritus), tops of his feet itched like crazy and the base of his toes and different parts of his body were itching but the skin only turned red a little bit from him scratching where it was itching, he felt his elbows and the back of his knees and his arm, anywhere there was skin to skin contact or hot, started feeling crazy and it was itching, had patches of red under each armpit, on his elbows and on his knees as well with raised bumps that were coming up. Outcome of the events was not recovered.  Follow-Up (15Nov2021): Follow-up attempts are completed. No further information is expected.