Cramp in left leg; it's still a little puffy there; she woke up with her left side neck swollen; she woke up with her left top of her shoulder swollen; she woke up with her left side face swollen; her arm was itchy; her arm was swollen; a rash; aching; temperature 100.8; tired; This spontaneous case was reported by a consumer and describes the occurrence of PERIPHERAL SWELLING (her arm was swollen), PERIPHERAL SWELLING (she woke up with her left top of her shoulder swollen), SWELLING FACE (she woke up with her left side face swollen), SKIN SWELLING (it's still a little puffy there) and SWELLING (she woke up with her left side neck swollen) in a 58-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch no. 039B21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     No medical history was provided by the reporter.  Concomitant products included ESTRADIOL, LISINOPRIL, ATORVASTATIN, LATANOPROST, MONTELUKAST, AZELASTINE and TRAMADOL for an unknown indication.   On 16-Apr-2021, the patient received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. On an unknown date, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 17-Apr-2021, the patient experienced RASH (a rash), MYALGIA (aching), PYREXIA (temperature 100.8) and FATIGUE (tired). On 18-Apr-2021, the patient experienced PERIPHERAL SWELLING (her arm was swollen) and PRURITUS (her arm was itchy). On 19-Apr-2021, the patient experienced PERIPHERAL SWELLING (she woke up with her left top of her shoulder swollen), SWELLING FACE (she woke up with her left side face swollen) and SWELLING (she woke up with her left side neck swollen). On 20-Apr-2021, the patient experienced SKIN SWELLING (it's still a little puffy there). On an unknown date, the patient experienced MUSCLE SPASMS (Cramp in left leg). The patient was treated with PARACETAMOL (TYLENOL) for Pain, at a dose of 1 dosage form and MENTHOL (ASPERCREME HEAT PAIN RELIEVING) (topical) for Muscle ache, at a dose of 1 dosage form. At the time of the report, PERIPHERAL SWELLING (her arm was swollen), PERIPHERAL SWELLING (she woke up with her left top of her shoulder swollen), SWELLING FACE (she woke up with her left side face swollen), SKIN SWELLING (it's still a little puffy there), SWELLING (she woke up with her left side neck swollen), MUSCLE SPASMS (Cramp in left leg), PRURITUS (her arm was itchy), RASH (a rash), MYALGIA (aching), PYREXIA (temperature 100.8) and FATIGUE (tired) outcome was unknown.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On 17-Apr-2021, Body temperature: 100.8 (High) body temperature is high.         Treatment included Ice.  Action taken with mRNA-1273 in response to the drug was not applicable.   This case was linked to MOD21-066335 (E2B Linked Report).   Most recent FOLLOW-UP information incorporated above includes: On 21-Jun-2021: Significant follow-up received on 21-JUN-2021 and one more event was reported that is Cramp in left leg along with treatment drug Aspercreme . On 24-Jun-2021: NNI received; Sender's Comments:  MOD21-066335: