Dramatic drop in her memory; Extreme abdominal Pain; This spontaneous case was reported by a patient family member or friend (subsequently medically confirmed) and describes the occurrence of AMNESIA (Dramatic drop in her memory) and ABDOMINAL PAIN (Extreme abdominal Pain) in a 91-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 012M20A and 002A21A) for COVID-19 vaccination.     The patient's past medical history included Aortic valve replacement (TAVR (Transcatheter aortic valve replacement)) on 11-Jun-2021. Concurrent medical conditions included AFib since 03-Sep-2011, Congestive heart failure (CHF (Congestive heart failure)) since 14-Oct-2011, Dementia vascular since December 2012, Type 2 diabetes mellitus since 2011, Tremor, Water retention, Back pain and Thyroid disorder. Concomitant products included DIGOXIN from 12-Jun-2017 to an unknown date for AFib, PARACETAMOL (TYLENOL) for Back pain, METOPROLOL SUCCINATE from 28-Jun-2017 to an unknown date, DILTIAZEM HCL and DILTIAZEM (CARDIZEM [DILTIAZEM]) from 21-Jul-2020 to an unknown date for Blood pressure management, DONEPEZIL HCL from 22-Apr-2014 to an unknown date for Dementia, NITROFURANTOIN, NITROFURANTOIN MONOHYDRATE (NITROFURANTOIN [NITROFURANTOIN;NITROFURANTOIN MONOHYDRATE]) from 08-Aug-2020 to an unknown date for Prophylaxis urinary tract infection, CALCIUM CARBONATE, VITAMIN D NOS (OSCAL D [CALCIUM CARBONATE;VITAMIN D NOS]) from 11-Jul-2014 to an unknown date for Supplementation therapy, L-THYROXINE [LEVOTHYROXINE] from 12-Jun-2017 to an unknown date and LEVOTHYROXINE SODIUM (SYNTHROID) from 12-Jun-2017 to an unknown date for Thyroid disorder, PRIMIDONE from 08-May-2012 to an unknown date for Tremor, SITAGLIPTIN PHOSPHATE (JANUVIA) for Type 2 diabetes mellitus, TORSEMIDE from 07-Oct-2011 to an unknown date and CHLORHEXIDINE GLUCONATE from 31-Aug-2017 to an unknown date for Water retention, ASCORBIC ACID, CALCIUM, MINERALS NOS, RETINOL, TOCOPHERYL ACETATE, VITAMIN B NOS, VITAMINS NOS, ZINC (CENTRUM SILVER [ASCORBIC ACID;CALCIUM;MINERALS NOS;RETINOL;TOCOPHERYL ACETATE;VITAMIN B NOS;VITAMINS NOS;ZINC]) from 11-Jul-2014 to an unknown date for an unknown indication.   On 05-Feb-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 05-Mar-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 06-Mar-2021, the patient experienced ABDOMINAL PAIN (Extreme abdominal Pain). On 05-Apr-2021,  after starting mRNA-1273 (Moderna COVID-19 Vaccine), the patient experienced AMNESIA (Dramatic drop in her memory). The patient was treated with OMEPRAZOLE on 01-Apr-2021 for Abdominal pain, at a dose of 20 mg once a day; CALCIUM CARBONATE (TUMS [CALCIUM CARBONATE]) for Adverse event, at an unspecified dose and frequency and Hospice care (Hospice due to her vascular dementia.) for Amnesia. On 07-Mar-2021, ABDOMINAL PAIN (Extreme abdominal Pain) had resolved. At the time of the report, AMNESIA (Dramatic drop in her memory) outcome was unknown.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On an unknown date, Blood glucose: normal (normal) No issues were found. On an unknown date, Laboratory test: normal (normal) No issues were found.         Products known to have been used by the patient, within two weeks prior to the event, included CVS (Chorionic villus sampling) digestive probiotic.   This case was linked to MOD-2021-030682 (Patient Link).