This is a spontaneous report from a Pfizer sponsored program reported by patient. A 45-year-old female patient received bnt162b2(PFIZER-BIONTECH COVID-19 VACCINE, Solution for injection with Batch/Lot Number: Not reported), via an unspecified route of administration on 30Jul2021 (at the age of 45-year-old) as DOSE 1, SINGLE for COVID-19 immunization. The patient medical history and concomitant medications were not reported. The patient experienced arm pain on 01Aug2021, the other day she felt like her heart was racing. On 02Aug2021 she's been on the bed for 3-4 hours crying for no reason, felt like little baby ants crawling all over her skin, she would get up every 5 to 10 minutes, anxiety attack, fast heartbeat and felt tingly all over. On 03Aug2021 she could not sleep, caller also stated that her appetite "sucks" right now, she was feeling thirsty but does not want to drink anything, she had anxiety/anxiety attack. Her massive migraine headaches were horrible on 04Aug2021. On an unspecified date patient had no appetite and was exhausted. Clinical course: On the first day she got the shot, she had arm pain for 2 days and on the third day, she had anxiety and has been on the bed for 3-4 hours crying for no reason. Patient said she never had anxiety before. Then on the fourth day, she said, she could not sleep since on the fourth and fifth day, she felt like ants were crawling all over her skin and she would get up every 5 to 10 minutes. Her appetite sucks right now and that her massive migraine headaches were horrible. Patient added that today she did not have any headache, but for five days in a row she had a migraine headache. Caller also mentioned feeling thirsty but does not want to drink anything and that last night was the only time she could eat and got 2 pieces of pizza but today she does not feel like eating again. First couple days she was fine but on the 3rd day she was out of it. She had anxiety and a panic attack. She had no appetite and has been exhausted with a fast heartbeat. She was unsure if she should receive the second COVID 19 vaccine or if there was an alternative. She added that she and her husband both received the COVID-19 vaccine. She was iffy about getting the vaccine because the whole thing was very scary. Her husband got his vaccine 2 weeks ago. She did not want to get the COVID-19 vaccine because she was afraid of needles and she was already not happy about getting the COVID-19 vaccine. Her husband talked her into getting the vaccine by telling her that she would either get the COVID-19 vaccine or she would end up in the hospital or dying with the COVID -19 virus. The first 2 days after her COVID-19 vaccine she was fine. On the third day she had a really bad anxiety attack. She spent hours on her bed crying for no reason. Her husband sat with her and rubbed her hair and cried with her and told her it was going to be ok. Her husband got her off the bed to go for a walk. She was up all night long every 10 to 15 minutes. It felt like little baby ants crawling all over her skin. She felt tingly all over and she didn't sleep at all. Her appetite was horrible. She was not eating anything. Last night was the first night she was able to eat a couple slices of pizza. The events outcome was reported as unknown. Follow up attempts completed. Information about lot/batch number cannot be obtained. No further information is expected..