Mentioned that his levels increased to 6.16 after the first booster that was administered on 27Sep2021; This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP). The reporter is the patient.  A 67-year-old male patient received BNT162b2 (BNT162B2), on 27Sep2021 as dose 3 (booster), single (Batch/Lot number: unknown) at the age of 66 years for covid-19 immunisation. The patient had no relevant medical history. The patient's concomitant medications were not reported. Vaccination history included: BNT162b2 (Pfizer/BioNTech COVID-19 Vaccine Details: Dose 1, single: , Time: Unknown , Anatomical Site of injection: Left deltoid , Route of Administration: intramuscular. , Batch/Lot number: EL8982), administration date: 03Feb2021, when the patient was 65-year-old, for COVID-19 immunization; BNT162b2 (Dose 2, single: , Time: Unknown , Anatomical Site of injection: Left deltoid , Route of Administration: intramuscular , Batch/Lot number: EN6201), administration date: 24Feb2021, when the patient was 65-year-old, for COVID-19 immunization. The following information was reported: PROSTATIC SPECIFIC ANTIGEN INCREASED (non-serious) with onset 27Dec2021, outcome "not recovered", described as "Mentioned that his levels increased to 6.16 after the first booster that was administered on 27Sep2021". Relevant laboratory tests and procedures are available in the appropriate section. Therapeutic measures were not taken as a result of prostatic specific antigen increased.  Additional information: Consumer with a potential AE on COVID-19 vaccine who reported that he had received five Pfizer covid-19 vaccines. Two of them were the two initial ones and three COVID-19 boosters and the last one was on 20Oct2022. Seemed the last booster was the Bivalent. Is going to get a biopsy done at a hospital because his PSA levels have gone up. Past three times it was at least 4 and the second to last time it increased to 6 something and on 11Nov2022 it got up to 9.24. Because it was trending up, they want to do a biopsy to see if it was prostate cancer. Information confirmed as provided his PSA levels had gradually gone up before he got the fourth vaccine. Had his first COVID vaccine in Feb2021 and the levels had gone up prior to that but not above the acceptable level. Acceptable level is 4.0. Later clarified that the levels had exceeded acceptable level in Aug2019 before he had the vaccines. Wanted to mention the two PSA levels prior to his first Pfizer COVID 19 vaccine that they were done in 2019 and one was 3.86 and 4.39 there was a trending increase that started before the first COVID booster. Later clarified that he has only had two PSA levels since he started the COVID 19 vaccinations. Provided that the PSA acronym is for the prostate specific antigen. PSA levels have gone up to 6.16: Mentioned that his levels increased to 6.16 after the first booster that was administered on 27Sep2021. Had the first PSA level done on 27Dec2021 and that level 6.16. Mentioned that there was a PSA done since then on 11Nov2022 and it rose to 9.24. he did not recover from it because it went up to 9.24. Treatment: Just monitored it no treatment. PSA level rose to 9.24: Does not know whether it has gone up, stayed the same or gone down. Clarified later in the report that the outcome as unknown. Treatment: Urologist wanted to do prostate biopsy to see if prostate cancer was present.  No follow-up attempts are possible; information about lot/batch number cannot be obtained. No further information is expected.