headache 9 minutes after shot (has happened with every mRNA vaccine); lymph nodes along jaw line swell and hurt; lymph nodes along jaw line swell and hurt; Sore throat; This spontaneous case was reported by a patient and describes the occurrence of OROPHARYNGEAL PAIN (Sore throat), HEADACHE (headache 9 minutes after shot (has happened with every mRNA vaccine)), LYMPHADENOPATHY (lymph nodes along jaw line swell and hurt) and LYMPH NODE PAIN (lymph nodes along jaw line swell and hurt) in a 50-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 002B21A and OUDB21A) for COVID-19 prophylaxis.     Patient not been tested and diagnosed for COVID-19.  Concurrent medical conditions included Chronic fatigue syndrome, Myofascial pain syndrome, Postural orthostatic tachycardia syndrome and Drug allergy (drug name not specified).   On 10-Mar-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 10-Apr-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 10-Mar-2021, the patient experienced HEADACHE (headache 9 minutes after shot (has happened with every mRNA vaccine)). In March 2021, the patient experienced OROPHARYNGEAL PAIN (Sore throat), LYMPHADENOPATHY (lymph nodes along jaw line swell and hurt) and LYMPH NODE PAIN (lymph nodes along jaw line swell and hurt). At the time of the report, OROPHARYNGEAL PAIN (Sore throat), HEADACHE (headache 9 minutes after shot (has happened with every mRNA vaccine)), LYMPHADENOPATHY (lymph nodes along jaw line swell and hurt) and LYMPH NODE PAIN (lymph nodes along jaw line swell and hurt) outcome was unknown.        For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown), the reporter did not provide any causality assessments.   No concomitant medication was reported. On 29NOV2021, patient received Pfizer booster as third dose with lot no FF2593 on left arm. On 08Oct2022, patient received Pfizer Bivalent as fourth dose with lot no GH9703 on left arm. Patient had headache after 9 minutes of Pfizer bivalent (also happened with every mRNA vaccine) and 25 minutes after shot had sore throat and lymph nodes along jaw line swell and hurt (had happened 10 hours after 1st shot,1 1/2 hours after second, and 30 min after 3rd). Within 2 hours of Pfizer bivalent all glands including in back of neck are very swollen so stiff and thick neck. Patient was in bed, feeling sick and back of neck resolves overnight, but sore throat and front neck and jawline glands are extremely swollen. Basically eating advil. About 30 hours after shot, they get better after that patient got a rash I get when body stressed. Rash lasts a couple of days. Took Benadryl and advil. Within 12hours of rash leaving, the glands and throat are bad again. Eat more advil. Unable to see doctor. Go to emergency on the 15th, told vaccine reaction. On 17th, still can't see doctor, but prescribed prednisone. Patient took it for 5 days 10mg, then 5mg then 2.5 mg due to sleeplessness. It helped pretty immediately. It took to about the 20th for throat/lymph resolved. The headache was recovering. No treatment information was reported for dose 1,2 and 3 events.