Mast Cell Activation. Severe edema in face and throat, severe hives all over the body, coming close to a year now. Fatigue, constant brain fog, reoccurring infections; Mast Cell Activation. Severe edema in face and throat, severe hives all over the body, coming close to a year now. Fatigue, constant brain fog, reoccurring infections; Mast Cell Activation. Severe edema in face and throat, severe hives all over the body, coming close to a year now. Fatigue, constant brain fog, reoccurring infections; Mast Cell Activation. Severe edema in face and throat, severe hives all over the body, coming close to a year now. Fatigue, constant brain fog, reoccurring infections; Mast Cell Activation. Severe edema in face and throat, severe hives all over the body, coming close to a year now. Fatigue, constant brain fog, reoccurring infections; Mast Cell Activation. Severe edema in face and throat, severe hives all over the body, coming close to a year now. Fatigue, constant brain fog, reoccurring infections; This is a spontaneous report received from contactable reporter(s) (Other HCP). The reporter is the patient.  A 22-year-old female patient (not pregnant) received BNT162b2 (BNT162B2), on 14May2021 as dose 2, single (Lot number: EW0173) at the age of 21 years, in right arm for covid-19 immunisation. The patient had no relevant medical history. The patient's concomitant medications were not reported. Vaccination history included: BNT162b2 (Dose Number: 1, Batch/Lot No: EW0164, Location of injection: Arm Right), administration date: 23Apr2021, when the patient was 21-year-old, for covid-19 immunization. The following information was reported: INFECTION (disability), OEDEMA (disability), MAST CELL ACTIVATION SYNDROME (disability), URTICARIA (disability), FATIGUE (disability), THINKING ABNORMAL (disability) all with onset 30Jul2021, outcome "not recovered" and all described as "Mast Cell Activation. Severe edema in face and throat, severe hives all over the body, coming close to a year now. Fatigue, constant brain fog, reoccurring infections". The events "mast cell activation. severe edema in face and throat, severe hives all over the body, coming close to a year now. fatigue, constant brain fog, reoccurring infections" required physician office visit and emergency room visit. Therapeutic measures were taken as a result of infection, oedema, mast cell activation syndrome, urticaria, fatigue, thinking abnormal. The patient was treated with Xolair injections, Zyrtec, singulair, allegra  Clinical Course: No other vaccine was taken in four weeks. Ae resulted in Doctor or other healthcare professional office/clinic visit, Emergency room/department or urgent care, Disability or permanent damage. The patient had covid prior vaccination but was not tested post vaccination.  No follow-up attempts are possible. No further information is expected; Sender's Comments: Based on the information in the case report, a possible causal relationship between reported events and suspect drug BNT162B2 cannot be excluded  The impact of this report on the benefit/risk profile of the Pfizer product is evaluated as part of Pfizer procedures for safety evaluation, including the review and analysis of aggregate data for adverse events. Any safety concern identified as part of this review, as well as any appropriate action in response, will be promptly notified to regulatory authorities, Ethics Committees, and Investigators, as appropriate