This spontaneous report was received from a consumer regarding a 50-year-old female patient. The patient's pertinent medical history and concurrent condition were unknown. The patient concomitant medication included diphtheria toxoid, pertussis acellular vaccine (unspecified), tetanus toxoid (TDAP) and drug reactions/allergies included allergic to morphine, DEMEROL and REGLAN. On 17-JUL-2018, the patient was vaccinated with M-M-R II 0.5 milliliter (Batch no. 06180214, lot # N027779 and expiry date was 29-NOV-2018) via intramuscular route for prophylaxis. On 17-JUL-2018, the patient stated that after getting one dose of the M-M-R II vaccination, the vaccine had "put my body in a tail spin (feeling abnormal). The patient explained that her employer required her to get vaccinated with M-M-R II because she had done some blood work on an unspecified date, which the test results showed she didn't have enough antibodies" for mumps, measles and rubella immunity protection (Measles antibody negative). The Patient said she ended up with her M-M-R II shot on 17-JUL-2018 in the muscle in the upper arm on the outside of her arm(incorrect route of administration). However, she said when the M-M-R II shot was first administered she felt the pain instantly (vaccination site pain). The Patient said "within 8 hours" of getting the vaccination she had a "significant amount of arm pain" (pain in extremity) to the point where she "could not move or bend the right elbow" (vaccination site joint movement impairment) and she could not extend her right arm to stretch the arm" (movement disorder) so she felt "very uncomfortable. The patient said "within the next 3 weeks post vaccination her entire body "completely ached from the back of her neck to her shoulders down to the lower back and ankles" and the pain all over her body was excruciating (pain). The patient said she was supposed to get a second M-M-R II shot for her employer 3 weeks after the first dose was given but she refused to get the second shot after the severe adverse reaction. The patient refused to have any other toxins put in my body. Patient also reported that she went from being an active person to being completely inactive" after getting the vaccine because since getting the M-M-R II, she had become incapacitated physically (hypokinesia) to the point where she cannot barely walk up or down the stairs" and she couldn't even carry a laundry basket or grocery bags with her right arm and now she had to do everything physically with her left arm which she said had been very frustrating (frustration). The patient also added she "can't carry any of her work belongings" in her right arm (limb discomfort) either and her work required her to do a lot of traveling but due to her physical health issues since getting the vaccine she had difficulty getting in or out of the car as well. Patient mentioned that an unspecified nurse who works at her employer told her she had developed "serum sickness (serum sickness) from patient the M-M-R II shot. The patient was gained 30 pounds (weight increased) and she has more severe migraines post vaccination (migraine). The patient said the most recent health issue she has developed was impaired vision (Visual impairment) and she was diagnosed through blood work she had done with developed an auto immune disease (autoimmune disorder) as well. The patient said post vaccination she has seen several physicians regarding her adverse event symptoms including seeing her nurse practitioner, an unknown endocrinologist and an unknown rheumatologist and she said she would be visiting to an unknown eye physician next Tuesday regarding the vision issues. The patient said post vaccination she had to have her thyroid medication SYNTHROID doubled because her thyroid had been completely out of control and she had to have an ultrasound later this month to check on her thyroid. Patient had to make some dietary changed by eliminating gluten from her diet (gluten free diet) and she could no longer have sugar or dairy either. Patient said the M-M-R II vaccination had been "debilitating" on her body physically and had put her entire health in a tail spin (asthenia). No product quality complaint involved. The patient sought for the medical attention. The outcome of autoimmune disorder, measles antibody negative, pain, asthenia, visual impairment, migraine, serum sickness, limb discomfort, weight increased, movement disorder, vaccination site pain, frustration, vaccination site joint movement impairment, pain in extremity, feeling abnormal and hypokinesia, gluten free diet and thyroid hormones increased was recovering. The reporter's causality assessment for the events was not provided. Upon internal review, the event of autoimmune disorder was considered to be serious (medically significant) and hypokinesia was considered as also serious (disability).