vomiting three times; Reached peak of pain; severe headache; monster headache due to all of the inflammation; This is a spontaneous report from a contactable consumer (patient). A 54-year-old female patient received first dose of bnt162b2 (PFIZER-BIONTECH COVID-19 mRNA VACCINE, Formulation: Solution for injection, lot number: EP7533, expiration date: 31Jul2021) via an unspecified route of administration, administered in left upper arm on 29Mar2021 between 08:00 and 10:30 (age at the time of vaccination was 54 years) as dose 1, 0.3ML single for COVID-19 immunisation at hospital. The patient's medical history included she had a lot of spinal issues and neck issues, ongoing chronic inflammation, when she was 28, it could have been a little before that. The patient's concomitant medication were included celecoxib (CELEBREX) indicated for chronic pain. No other product. There was no history of all previous immunizations with the Pfizer vaccine considered as suspect and no additional Vaccines administered on same date of the Pfizer suspect. There were no other vaccinations within four weeks, prior to the first administration date of the suspect vaccine. No any illness at time of vaccination. There was no family Medical History relevant to adverse events and no relevant tests. The patient received the first dose of the Pfizer COVID-19 vaccine on 29Mar2021 and was scheduled to receive the second dose on 19Apr2021. She took Celebrex daily for chronic pain and her HCP (health professional) who prescribed the Celebrex advised her to hold her Celebrex 3 days prior to the vaccine, the day of the vaccine and 3 days after the vaccine because of the potential for decreased immune response. She stated that by the 6th day of holding her Celebrex she had a monster headache due to all of the inflammation and vomited. She developed a severe headache that resulted in vomiting three times. She stated she got headaches and she knew the differences in her types of headaches. Caller states well she has issues, lots of medical issues that bring about headache, so she cant tell me if its there because of the vaccine or if its there because of the other problems that she has. She stated it was clearly not a migraine. She stated that the headache was brought about by the discontinuation of the anti-inflammatory. The headache reached peak of pain somewhere around 16:00 and it just intensified and intensified until she finally started vomiting at 22:30 at night. She would like information on a different regimen for her Celebrex prior to taking the Pfizer COVID-19 vaccine so that it did not interfere with immune response but also did not cause the same issue as she had with the first dose. She had not notified her health professional of what happened when she stopped taking the Celebrex as directed. The patient stated she took ondansetron, which was prescribed for her and that helped and there was no more vomiting on Friday, 02Apr2021. She did not visit emergency room and physician office. The outcome of headache was recovering, outcome of vomiting was recovered on 02Apr2021, and outcome of other events was unknown   No follow-up attempts were possible, Information about lot/batch number could not be obtained.