right leg was paralyzed; pain; could not breathe; feet were swollen/arm swelling; allergic reaction to adacel; nausea; Chicken Pox; Shingles; fever of 103 fahrenheit; diarrhea; appetite loss; rash on chest, rash worsened to her right hand and legs; Initial information received on 11-Mar-2021 regarding an unsolicited valid serious case received from a consumer.  This case involves a 46 years old female patient who experienced right leg was paralyzed (monoplegia), pain, could not breathe (dyspnoea), feet were swollen/arm swelling (swelling of limbs), chicken pox (varicella), shingles (herpes zoster), allergic reaction to adacel (allergy to vaccine), appetite loss (decreased appetite), rash on chest, rash worsened to her right hand and legs (rash), nausea, fever of 103 fahrenheit (pyrexia) and diarrhea (diarrhoea), while she received vaccine DIPHTHERIA-2/TETANUS/5 AC PERTUSSIS VACCINE [ADACEL].  Past vaccination included Tetanus injection previously in JUN-2003 (no reaction at that time).  Medical history, medical treatment, concomitant medication and family history were not provided.  On 03-Mar-2021, the patient received a dose of suspect DIPHTHERIA-2/TETANUS/5 AC PERTUSSIS VACCINE (lot number and expiry date: not reported) via an unknown route in the left arm for prophylactic vaccination.  On 05-Mar-2021, the patient developed a non-serious diarrhea (diarrhoea), rash on chest, rash worsened to her right hand and legs (rash), fever of 103 fahrenheit (pyrexia) and appetite loss (decreased appetite) two days following the administration of DIPHTHERIA-2/TETANUS/5 AC PERTUSSIS VACCINE.  Also reported that Appetite loss so she drank Pedialyte for 2 days. The patient health care professional (HCP) gave her medications for the rash.  On 08-Mar-2021, the patient went back to the HCP who thought she might be having non-serious chicken pox (varicella) or shingles (herpes zoster), five days following the administration of DIPHTHERIA-2/TETANUS/5 AC PERTUSSIS VACCINE. so doctor started her on Acyclovir and Hydroxyzine On 09-Mar-2021, the patient went to a specialist who took the patient off of Acyclovir and put her on Valacyclovir instead and kept her on Hydroxyzine six hours.  On 10-Mar-2021, the patient rash worsened to her right hand and legs.  On 10-Mar-2021, the patient developed a non-serious feet were swollen/arm swelling (swelling of limbs), could not breathe (dyspnoea), seven days following the administration of DIPHTHERIA-2/TETANUS/5 AC PERTUSSIS VACCINE.  On 10-Mar-2021, the patient developed a serious right leg was paralyzed (monoplegia), seven days following the administration of DIPHTHERIA-2/TETANUS/5 AC PERTUSSIS VACCINE. This event was assessed as medically significant. So her husband drove her to the emergency room (ER).  On 10-Mar-2021, the patient developed a non-serious pain, rash, arm swelling and nausea and the HCP stated that it was an allergic reaction to the Adacel (allergy to vaccine), seven days following the administration of DIPHTHERIA-2/TETANUS/5 AC PERTUSSIS VACCINE. That she should call and let us know today. They gave her a steroid for 10 days to treat the allergic reaction. The HCP stated that because of this, she should not get the Coronavirus Disease (Covid) Vaccine because it would feel like a worse reaction than th  Reporter relationship: Self Product used: Used First time product used: No Still using product: No  Other relevant laboratories details not reported.  At the time of reporting, the outcome of events were reported as unknown.  Information on the batch number was requested.; Sender's Comments: This case involves a 46 years old female patient who had monoplegia, pain, dyspnoea, peripheral swelling, varicella, herpes zoster, allergy to vaccine, decreased appetite, rash, nausea, pyrexia and diarrhoea, after receiving ADACEL. The time to onset is compatible. Past vaccination included Tetanus injection. Additional information regarding patient's medical history, condition at the time of vaccination, lab data excluding other predisposing etiologies would be needed for complete assessment of the case. Based upon the reported information, the role of the vaccine cannot be assessed.