Redness and swelling in legs; Redness and swelling in legs; Got bit by a bug and her immune system went into overdrive; This is a spontaneous report from a contactable consumer or other non hcp (patient reported for herself). A 67-year-old female patient received BNT162B2 (PFIZER-BIONTECH COVID-19 mRNA VACCINE, Formulation: Solution for injection, batch/lot number was not reported), via an unspecified route of administration in Arm Right on 28May2021 at 14:11 (at the age of 67-year-old) as dose 2, single for COVID-19 immunization at clinic (The vaccine was not administrated at facility). Medical history included ongoing seasonal allergy (had since childhood), ongoing vitamin d low levels (does not know how long she has had. She was fatigued and gaining weight. She did not know she had it until she had tests), Gaining weight and fatigued from an unknown date and unknown if ongoing (she was fatigued and gaining weight), ongoing reactive high blood pressure (probably had entire life. she will get so mad. blood pressure controlled now), bronchitis from an unknown date and unknown if ongoing, Penicillin allergy from an unknown date and unknown if ongoing (caller stated that her family had a reaction to penicillin). Concomitant medications included (VITAMIN D [VITAMIN D NOS]) taken for vitamin D levels so low (have to do for life), start and stop date were not reported and amlodipine taken for reactive high blood pressure from an unspecified start date and ongoing (been on for a little over a year in April). The patient previously received first dose of BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE, batch/lot number was not reported) via an unspecified route of administration in left arm on 28Apr2021 at 14:11 (at the age of 67-year-old) as single dose for COVID-19 immunization and experienced swelling left arm and ankle and feet swelling. The patient previously took sulfa [sulfanilamide] for bronchitis and experienced rash and anaphylactic reaction (Her doctor told her to take the last 2 pills. She took another pill with the rash and had an anaphylactic reaction and had to go to the emergency room). Investigation assessment was not provided. It was reported that on 28May2021 the patient received the second dose of vaccine and stated that on 06Jun2021 she experienced redness and swelling in legs and got bit by a bug and her immune system went into overdrive. She stated that she had 2 shots for Pfizer vaccine first one she had swollen arm that went down after 2 days. For the second shot she had no problem, no swelling, nothing. She had no reaction. Second shot was 26May2021. Later caller clarified that it was 28May2021. She went out on Sunday, 06Jun2021, to the lake and there were a bunch of gnats and biting things. She said she has seasonal allergies. She said normally if she was bit, with a mosquito bite, she would get a big red area reaction about the size of a quarter and would take like 2 days to go down. On Sunday, she was bit one time on one leg, and twice on the other leg. Her immune system went into overdrive. She was bit on Sunday with little bug bites, only about 2 of them. She can see them now that her swelling has gone down. She should have had at most a quarter sized red area from them. Instead, caller described that half of her leg swelled up. It wrapped around the back of her leg and on the other side it was the size of a dollar bill. It merged around the back like a band strip about an inch wide. The left leg, with the 2 marks, was the more severe reaction, it was about a foot and a half. It narrowed down to 6 inches and wrapped around about 8 inches. Then caller confirmed it actually narrowed down to 4 inches on the side. The front was 8 to 10 inches. The spots were fire engine red. The one with the 2 spots was layering like a burn victim. It was red and then layered with red purple on top. It swelled up. It was both of her legs. All of it swelled up like a fire engine. One side swelled up more. Caller stated she already got medication for her allergies. She bet this was related to a reaction with the covid shot and her immune system. She had to do virtual appointment. She didn't talk to her doctor. She talked to virtual. She said she is not a doctor. She thought it was probably body doing immune things. It was hyperdrive. The covid shot set the immune system into overdrive. Caller said she didn't think of the Pfizer shot. She hadn't been bitten by anything yet. It didn't cross her mind that it was related to something. She had allergies all her life and never had reaction like this. She then realized she just had shot that dealt with immune system. Nothing else was in environment or food that was done differently. She was wondering why she had reaction now and not before. It was only the vaccine. She thought the vaccine was good. She wanted to make sure we knew that if people have allergies to insects or something not to expose to bugs for a while. Treatment for Events: virtual doctor gave her Prednisone and Betamethasone Dipropionate Cream as treatment. Right away after the first pill of Prednisone it stopped spreading. The doctor said to seek treatment if it didn't help. The first Prednisone stopped it spreading. The cream didn't do much for the spreading until the second dose of the Betamethasone cream. The cream didn't do much. It made it less red, but it didn't shrink the size. The second Prednisone pill shrunk the size of the red. Application of the cream lessoned the intensity of colour. The third pill was today. When caller was asked if she was a healthcare provider, she said she was a doctor. She clarified that she was a PhD and had done medical research. She had done ethnography and knew how important studies were. Caller did not want to provide email address. Caller did not want to provide any information about the primary healthcare provider. She stated that she was transitioning with her doctor. Her primary doctor passed away. She used virtual. She thought she had found a good one, but then they forgot a prescription. She hadn't found an adequate doctor. They forgot to do things. Caller stated that she had deficiency of Vitamin D. Her level was so far below. It was almost 0. She needed a supplement, and they did not look at the results from her levels until 2 weeks later. Caller said she had been worried about cellulitis with this reaction that she is reporting. She had a friend that lost his toes from an injury and cellulitis. It was so sudden and severe. She thought this was a reaction. She mentioned that Redness and swelling in legs has dramatically improved. She was guessing that after she does the 3rd application of her Betamethasone Dipropionate Cream it will be gone. The patient was recovering from the events of redness of legs and swelling of legs and outcome of the event immune system disorder was unknown.  Information on Lot/Batch number has been requested.