numbness around her face, mouth, and tongue; chest pain/pressure; chest pain/pressure; This is a spontaneous report received from contactable reporter Consumer or other non Health professional from medical information team. The reporter is the patient.  A 22 year-old female patient received bnt162b2 (PFIZER-BIONTECH COVID-19 mRNA VACCINE, Formulation: solution for injection, Lot Number: Unknown; Expiration Date: Unknown),via an unspecified date, administered in arm right, on 27Oct2021 (at the age of 22 years), as dose 1, single for COVID-19 immunization. The relevant medical history included Period management from an unspecified date and was unspecified if ongoing. the concomitant medications included: DEPO PROVERA taken for menstrual cycle management and was ongoing. On 27Oct2021, the patient experienced numbness around her face, mouth, and tongue, chest pain/pressure, which were considered serious due to medical significance. The events were evaluated at the emergency room visit. The therapeutic measures were taken as a result of hypoaesthesia, chest pain, chest discomfort. The clinical outcome of all the events was unknown at the time of this report. Clinical course: It was reported that the caller received the first dose of Pfizer COVID-19 vaccine in Oct2021 and  experienced numbness around her face, mouth, and tongue thirty minutes after she received the first dose. The patient had a similar experience after receiving the second dose of the vaccine. However, it was a minor reaction. She had some numbness and tingling around her face, mouth, and tongue. She explained the doses were split. She received half a dose and waited 30 minutes to be received the other half which may have caused a minor reaction. Caller was also given allergy medication before she receives her second dose of the vaccine. She mentioned that the symptoms lasted 24 to 48 hours. Her mouth and jawline were numb, and she was talking weird. Caller wanted to know if those symptoms were normal and associated with the Pfizer COVID anti vaccine or not. Response: Informed caller the symptoms she described above have not been listed as reported side effect in the fact sheet. However, we may not have the list of all the possible potential side effects related to the vaccine. If she is still experiencing these symptoms, she may consult her doctor for more information. It was further reported that caller inquired about Zoloft. caller had experienced vaginal bleeding a couple of hours after taking the medication. She mentioned every time she took the medication she experienced vaginal bleeding. The caller was looking for additional information. The caller stated she was prescribed by her doctor to take Zoloft and states she wants to report an adverse reaction, stated she was taking Zoloft, states when she started taking medication, she started having vaginal bleeding, Calrified that she started the Zoloft on 16Dec2021, stated she started bleeding the same day within the same day, stated it started maybe a couple hours after she took the medication. Caller stated she realized that she does not get a menstrual cycle because she is on Depo Provera, stated the bleeding was heavy and was like blood clots. Caller stated she discontinued the medication because the bleeding was consistent with her taking the medication, stated she took it on 16th and bleeding was heavy, the prescription was for once a day, and through the day it would get lighter, and then the next time she took it the bleeding would get heavy again and get lighter through the day. Discontinued around or before 30Dec2021. Caller also wanted to report that she also had an adverse reaction to the COVID vaccine. Caller stated that she got first shot on 27Oct2021, states after the vaccine she had to go to the ER, stated her entire face, mouth, and tongue went numb 30 minutes after the shot. Also got chest pain/pressure, caller stated she was not admitted to the hospital, was discharged the same day, got the shot early afternoon. Treated her with allergy medication, Benadryl and some other form of allergy medication that started with a Z, details of this medication are unknown. Stated her second dose was administered on 18Nov2021, stated that instead of giving her the full dose this time, she got two shots, half and half, stated she had a minor reaction this time but still had the face tingling it was still there. clarified they gave both half doses on 18Nov2021. Stated they had her wait 30 minutes to an hour between the half doses. Had the same treatment of allergy medication after second dose. NDC, Lot and Expiration Unknown. Caller does not have her vaccination card at this time. The caller wanted to know if those experiences have anything to do with the medications. HCP Contacted information unknown. Zoloft was clarified as sertraline, stated it was dispensed in a pharmacy vial. LOT, Expiration Date and manufacturer were unknown. The caller stated she has been taking Depo Provera for over 3 years, stated she started it when she did not want to have a period in 100 degree weather.  The lot number for bnt162b2 was not provided and will be requested during follow up.