stage 3 kidney failure; Chronic Fatigue (I've had for 30 years) got significantly better/Chronic Fatigue got significantly better; 2 instances of shingles; symptoms of not feeling well; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP) from medical information team. The reporter is the patient.  A 65-year-old female patient received BNT162b2 (BNT162B2), on 25Mar2021 as dose 2, single (Lot number: ER8733) at the age of 65 years for covid-19 immunisation. The patient's relevant medical history included: "Chronic fatigue" (ongoing), notes: Chronic fatigue Had for 30 Years; "she can't remember when her first shingles outbreak was but it was during the Summer" (unspecified if ongoing), notes: Caller reports she had Shingles before and had not had the Shingrex vaccine. There were no concomitant medications. Vaccination history included: BNT162b2 (Dose 1, single, Lot: EN6200), administration date: 26Feb2021, when the patient was 65-year-old, for COVID-19 immunization. The following information was reported: MALAISE (non-serious) with onset Apr2021, outcome "recovered", described as "symptoms of not feeling well"; RENAL FAILURE (medically significant), outcome "recovering", described as "stage 3 kidney failure"; THERAPEUTIC RESPONSE UNEXPECTED (non-serious), outcome "recovered", described as "Chronic Fatigue (I've had for 30 years) got significantly better/Chronic Fatigue got significantly better"; HERPES ZOSTER (non-serious), outcome "recovered", described as "2 instances of shingles". The events "stage 3 kidney failure" and "2 instances of shingles" required physician office visit. The patient underwent the following laboratory tests and procedures: kidney labs: Stage 3 Kidney Failure, notes: it showed she had Stage 3 Kidney Failure; Mammogram: Unknown results; Urine analysis: Stage 3 Kidney Failure, notes: had Stage 3 Kidney Failure. Therapeutic measures were taken as a result of renal failure.  Clinical course: Patient had 2 doses of your Corona Virus vaccine. After the 2nd dose his Chronic Fatigue (had for 30 years) got significantly better, went into stage 3 kidney failure, and had 2 instances of shingles. He would like to take booster in the Fall to see if it would help Chronic Fatigue again, but doctors are concerned for kidneys. 2 weeks after the second dose, she experienced symptoms of not feeling well and then when that passed after a couple of weeks. During the 2 weeks of not feeling well, her kidneys were sore and when they did a urine test and kidney labs, it showed she had Stage 3 Kidney Failure. So, she changed her diet because of what her Homeopath recommended. She saw Kidney Specialists and they didn't have any recommendations they were just going to do a watch and wait and that was concerning to her. It was her Homeopath that gave her a diet change and recommended some renal supplements that she did for a month and then her kidney functions improved, and everything was okay at that point. She can't remember when her first shingles outbreak was, but it was during the Summer, and it was on her right shoulder. States she went to walk in clinic and the physician said in the last few months she had seen more Shingles outbreaks from people who had the Covid 19 vaccine than she had seen in the last 5 years. during her Mammogram at her annual visit, the doctor there also said that she has seen a remarkable number of patients that have gotten Shingles after having the Covid Vaccine. She didn't say which vaccine. She never asked if the patients had had shingles before or if they had the Shingrex vaccine. She had Shingles before and had not had the Shingrex vaccine. She does have the Shingrex vaccine now. Caller additionally reports during a wellness visit, her doctor also knew of a lot of people who had got Shingles that had gotten the Vaccine. She was not saying the Covid Vaccine causes Shingles, but it sparks something in people's body if they are prone to it. Her Spouse didn't get shingles after his vaccine. A couple of weeks after her symptoms of not feeling well had passed was when she realized her Chronic Fatigue was better. She had more energy and stamina. It got even better that Spring and Summer, and then it started to wain after 6 months then after a year all the positive effects had worn off. There was a website, she can't remember the name of it, but people report that their Chronic Fatigue either got better or worse after the Covid vaccine. there are dozens of people who have reported they have found improvement from getting the vaccine. Most of those people said theirs was more fleeting, lasting 3-6 months. States no one reported a year like hers, she seems to be an anomaly in that regard. It seemed to have stimulated some positive immune response with her Chronic Fatigue Syndrome. There was no mechanism to report or a forum to chat with others they have had improvement.