This case was reported by a other health professional via call center representative and described the occurrence of tiredness in a 72-year-old male patient who received SHINGRIX for prophylaxis. Previously administered products included SHINGRIX with an associated reaction of fatigue (On 10th May 2018, received 1st dose refer case US2018GSK165654). On 14th August 2018, the patient received the 2nd dose of SHINGRIX (intramuscular). In August 2018, less than a month after receiving SHINGRIX, the patient experienced shingles. On an unknown date, the patient experienced tiredness, sweating, influenza-like symptoms, neuralgia, shivering, injection site cellulitis, injection site erythema, injection site warmth, headache, jaw pain, nausea, dizziness, abnormal physical sensation, diarrhea, neck pain, shoulder pain and pain. The patient was treated with Valtrex and Capsaicin Cream. Rechallenge with SHINGRIX was positive. On an unknown date, the outcome of the tiredness, sweating, influenza-like symptoms, neuralgia, shivering, injection site cellulitis, injection site erythema, injection site warmth, headache, jaw pain, diarrhea, neck pain, shoulder pain and pain were recovered/resolved and the outcome of the nausea, dizziness and abnormal physical sensation were unchanged and the outcome of the shingles was recovering/resolving. It was unknown if the reporter considered the tiredness, sweating, influenza-like symptoms, neuralgia, shivering, injection site cellulitis, injection site erythema, injection site warmth, headache, jaw pain, nausea, dizziness, abnormal physical sensation, shingles, diarrhea, neck pain, shoulder pain and pain to be related to SHINGRIX. Additional details were provided as follows: This case was reported by other health professional for himself. The patient received 2nd dose of SHINGRIX in the left arm. After receiving second shot of the SHINGRIX, the patient experienced intense shivering, flu like symptoms, sweats, soreness, neuralgia, diarrhea, tiredness and headache. The patient had achiness in his right jaw, down to neck and shoulder area. All of these symptoms were lasted for total of 4 days. He also experienced cellulitis on the left arm associated with redness and warmth. The redness was covered in 4 to 6 inches of area from the injection site down to the elbow. This was lasted for total of one week. Currently the patient was experiencing waves of nausea, dizziness, and funny feeling in the face and arms. He stated that when he moved his eyes he felt very dizzy and nauseated. Within 2 weeks of getting the second shot he had a case of Shingles on the left arm, shoulder and arm pit. The patient required a doctor's visit for the Shingles he was experiencing. He was then prescribed Valtrex and capsaicin cream. He was recovering from the Shingles. No further details were provided. The reporter did not have his health care physician's information. This case has been linked with case US2018GSK165654, reported by same reporter for same patient. The reporter was a dentist reporting total of 4 adverse events. Two for himself, one for his wife and two for his friends. This was case was 1 of the 5 cases reported by the same reporter.