Caller mentioned she took a booster from Pfizer and her inflammation disappeared/Three weeks later, her inflammation was down at least 60%; This is a spontaneous report received from a contactable reporter(s) (Consumer or other non-HCP) from medical information team, Program ID: The reporter is the patient.  A 65-year-old female patient received BNT162b2, BNT162b2 omi ba.4-5 (BNT162B2, BNT162B2 OMI BA.4-5), on 01Nov2022 as dose 4 (booster), single (Lot number: GH9697) for covid-19 immunisation. The patient's relevant medical history included: "Hashimotos" (unspecified if ongoing); "mixed connective tissue disease" (unspecified if ongoing); "psoriasis" (unspecified if ongoing), notes: Its just psoriasis on her ankle that she puts coconut oil on; "tendons" (unspecified if ongoing); "ligaments" (unspecified if ongoing); "autoimmune diseases" (unspecified if ongoing); "ear and sinus infections a year" (unspecified if ongoing); "ear and sinus infections a year" (unspecified if ongoing), notes: usually secondary from colds and allergies. The patient's concomitant medications were not reported. Past drug history included: Monolaurin, notes: for five years. Vaccination history included: BNT162b2 (Dose 1, Single, Lot: ER8733, did not have expiration dates on her immunization card), administration date: 25Mar2021, for Covid-19 immunization, reaction(s): "her inflammation disappeared"; BNT162b2 (Dose 2, Single, Lot: EW0153), administration date: 15Apr2021, for Covid-19 immunization, reaction(s): "her inflammation disappeared"; BNT162b2 (Dose 3 (Booster), Single, Lot: FJ8762), administration date: 10Dec2021, for Covid-19 immunization, reaction(s): "The effects of this one lasted a little bit longer". The following information was reported: THERAPEUTIC RESPONSE UNEXPECTED (non-serious), outcome "unknown", described as "Caller mentioned she took a booster from pfizer and her inflammation disappeared/Three weeks later, her inflammation was down at least 60%".  Additional information: Caller has a history of autoimmune diseases, including Hashimotos, mixed connective tissue disease, and the other one is like no big deal, its annoying, but no one sees it. Its just psoriasis on her ankle that she puts coconut oil on. It just kind of soothes it so it doesn't get itchy. With her autoimmune disease, when she has one of them attacks, tendons and ligaments, they get inflamed and she can't move. Caller states she has no complaints about the vaccine. She sent an email to Pfizer last year to let them know of all the amazing benefits she got from the vaccine. She got a packet in the mail, but it was asking about adverse events and she didn't have any. She's been thinking about calling Pfizer for a long time because obviously sending the email explaining this didn't work because she's not getting negative effects. She received fourth dose of the Pfizer bivalent vaccine on 01Nov2022. Now in a few weeks it will have been 6 months and its been wearing off for the past couple weeks, and the pain is getting very severe again. Yesterday on 25May2023 she got the Moderna Covid vaccine. They told her she could get the Moderna or get nothing so she is giving the Moderna shot a chance. She doesn't know if its going to work the same way, she's never had it before. She's talked to her doctor, rheumatologist, pharmacist, about why this is happening. They can't think of any reason why. She came up with own theory, uneducated theory. She thinks that when you get the vaccine it freaks her immune system out and stops attacking her. Or there's some ingredient in the vaccine that is soothing her immune system. It lessens the attacks, there's got to be a reason for that. She has tried to look at research articles but they're all so far over her head she doesn't understand what its saying. When Covid first started, her primary care doctor told her that she was afraid that if because of her autoimmune and other stuff that if she got Covid she wouldn't survive. So she's been isolated since then and when she goes out she still wears a mask. She also isn't that afraid of getting Covid because she takes a supplement called Monolaurin. It penetrates bacteria and viruses that have a lipid membrane and deactivates it. And the Covid virus has a lipid membrane. She used to get 8, 10, 12 ear and sinus infections a year, usually secondary from colds and allergies. She's been on Monolaurin for 5 years, she has not had since, not any cold or flu since then at all. Sender's Comments: Linked Report(s): US-PFIZER INC-202300204260 same patient/event, different dose; US-PFIZER INC-202200016205 same patient/event, different dose.