This spontaneous case was reported by a consumer and describes the occurrence of INFLAMMATION (inflammation in her right hand/Hands are so inflamed that her vein cannot be seen), EFFUSION (wrist is inflamed like a water balloon/Body feels like water balloon/She is a walking water balloon), SKIN TIGHTNESS (Skin is tight/Skin does not look soft/Skin so tight that it is shining), PERIPHERAL SWELLING (Hands are so inflamed that her vein cannot be seen/Can't hold change in her hands because she will drop it) and JOINT SWELLING (Her knuckles are inflamed/Can't make a full fist/Her knuckles are bent and tight/Knuckles like that of a 70-year-old) in a 57-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 040B21A and 038A21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below. The patient's past medical history included Multiple sclerosis (Multiple sclerosis for 24 years). Concurrent medical conditions included Inflammation (Worsening of Inflammation of her hands started with her right hand now its all over her body) since 20-May-2021 and Effusion of joint (worsening of Fluid building up in her joint under her skin) since 01-Jul-2021. On 16-Mar-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 15-Apr-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. On 15-Apr-2021, the patient experienced INFLAMMATION (inflammation in her right hand/Hands are so inflamed that her vein cannot be seen) and VACCINATION SITE INFLAMMATION (inflammation in her left hand). In April 2021, the patient experienced EFFUSION (wrist is inflamed like a water balloon/Body feels like water balloon/She is a walking water balloon). On an unknown date, the patient experienced SKIN TIGHTNESS (Skin is tight/Skin does not look soft/Skin so tight that it is shining), PERIPHERAL SWELLING (Hands are so inflamed that her vein cannot be seen/Can't hold change in her hands because she will drop it), JOINT SWELLING (Her knuckles are inflamed/Can't make a full fist/Her knuckles are bent and tight/Knuckles like that of a 70-year-old), SWELLING FACE (Inflammation in her cheek), PAIN (She is in pain physically), FEAR (She is afraid), LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (It has impacted her everyday life), ANXIETY (She is worried she might) and IMPAIRED WORK ABILITY (not be able to work.). At the time of the report, INFLAMMATION (inflammation in her right hand/Hands are so inflamed that her vein cannot be seen), EFFUSION (wrist is inflamed like a water balloon/Body feels like water balloon/She is a walking water balloon), SKIN TIGHTNESS (Skin is tight/Skin does not look soft/Skin so tight that it is shining), PERIPHERAL SWELLING (Hands are so inflamed that her vein cannot be seen/Can't hold change in her hands because she will drop it), JOINT SWELLING (Her knuckles are inflamed/Can't make a full fist/Her knuckles are bent and tight/Knuckles like that of a 70-year-old), SWELLING FACE (Inflammation in her cheek), PAIN (She is in pain physically), FEAR (She is afraid), LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (It has impacted her everyday life), ANXIETY (She is worried she might), IMPAIRED WORK ABILITY (not be able to work.) and VACCINATION SITE INFLAMMATION (inflammation in her left hand) had not resolved. Patient went various doctor's office. No concomitant medication were reported. No treatment drug were added.