trouble getting in and out of the bed and toilet; felt like a strong muscle weakness; couldn't eat; foggy brain; total complete fatigue; normal fatigue; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP). The reporter is the patient.  An 82-year-old female patient received BNT162b2 (BNT162B2), on 25May2022 as dose 4 (booster), single (Lot number: FM7553) at the age of 82 years for covid-19 immunisation. The patient's relevant medical history included: "Polyarthritic Arthritis" (unspecified if ongoing); "Fibromyalgia" (unspecified if ongoing); "Psoriatic arthritis" (unspecified if ongoing); "Osteoarthritis" (unspecified if ongoing); "Prosthetic Right Hip" (unspecified if ongoing), notes: Prosthetic Left Arm, Prosthetic Right Hip; "pain" (unspecified if ongoing); "Blood Pressure" (unspecified if ongoing); "diabetes" (unspecified if ongoing); "heart regulating" (unspecified if ongoing). Concomitant medication(s) included: LOSARTAN taken for blood pressure measurement; METFORMIN taken for diabetes mellitus, start date: 2005; METOPROLOL taken for cardiac disorder; METHOTREXATE; HYDROCODONE taken for pain. Vaccination history included: BNT162b2 (Dose 1, Lot EL3246, she received all 4 doses in the right arm), administration date: 05Feb2021, when the patient was 81-year-old, for Covid-19 immunization; BNT162b2 (Dose 2, Lot EN6198, she received all 4 doses in the right arm), administration date: 26Feb2021, when the patient was 81-year-old, for Covid-19 immunization; BNT162b2 (Dose 3, Lot EW0178, First Booster Dose, she received all 4 doses in the right arm), administration date: 27Oct2021, when the patient was 81-year-old, for Covid-19 immunization; flu shot, administration date: 19Sep2021, when the patient was 81-year-old, for Immunization, reaction(s): "she had a mild bad reaction". The following information was reported: FATIGUE (non-serious) with onset 26May2022, outcome "recovered with sequelae" (27May2022), described as "total complete fatigue; normal fatigue"; BEDRIDDEN (non-serious), outcome "unknown", described as "trouble getting in and out of the bed and toilet"; MUSCULAR WEAKNESS (non-serious), outcome "unknown", described as "felt like a strong muscle weakness"; DECREASED APPETITE (non-serious), outcome "unknown", described as "couldn't eat"; FEELING ABNORMAL (non-serious), outcome "unknown", described as "foggy brain". Relevant laboratory tests and procedures are available in the appropriate section.  Additional Information: Caller states that she is calling about her Second booster shot. She does not know the specific name but clarified it was the covid vaccine. She is calling to report that she has a bad reaction to the second Booster. Caller was asked to elaborate as to what was meant by Bad reaction, she explained that it was total complete fatigue, describing that she couldn't get out of bed, she felt like a strong muscle weakness, she couldn't eat, she did drink a lot of water, she had trouble getting in and out of the bed and toilet, she had to wear a diaper, she is 82 years old. Caller clarified that she does have arthritis but with that and everything she can do a lot of things like walk, but after this second booster, this kept her in bed for more than 24 hours. She also has foggy brain that she is just getting of. Caller states that all of her covid vaccines were from Pfizer, and all done at the (withheld). Caller states that she was 81 years old when she got the first, second, first booster dose. She was age 82 when she got the second booster. The total complete fatigue started the next morning after getting the second booster, the shot was late afternoon on 25May2022. This fatigue was bad, now she just has her normal fatigue, but this was unusual, she had to use a walker to get to the bathroom. The total complete fatigue subsided Friday, on Friday 27May2022 she was able to get up and walk normal. The only thing that is staying is brain fatigue or fog, it is very mild and is clearing. Caller states that she received all 4 doses in the right arm, caller clarified that she has a prosthetic left arm. Caller states that she would also like to add that she had a mild bad reaction to her last flu shot, she always gets annual flu shots with no problems but this is the first time she had a reaction, so this is the 2nd time in her life that she has had a reaction with a vaccine. When probed for the product details of the Flu Shot, she states that the Flu Shot name is Unknown,  Lot is Unknown, it was done at the doctors office, caller confirms it was at the PCP she provided. She thinks she got this Flu shot on 19Sep2021. She takes a variety of medications. She has diabetes, stating that now actually she would be considered as pre diabetes since she has brought her A1C down low. Her Blood Pressure medication dose was cut in half because it was making her dizzy, that was a few years ago specifically 2 years ago, the blood pressure medication is losartan. She is on a heart regulating Metoprolol. She is on Metformin. She has bad arthritis, and is on hydrocodone for pain. She only takes her regular medications. She is on methotrexate. Caller also explains that Metformin was cut in half as of last week, she further explained that prior in 2005 her Metformin dose was 2000mg a day, then back about 7-8 years ago it was cut to 1000mg, then last week they cut it to 500mg. Her A1C has now reduced to 5.7 this result was taken on 20May2021.  Originally her A1C was 8.6 in 2005. The patient underwent the following laboratory tests and procedures: Glycosylated haemoglobin: (2005) 8.6; (20May2022) 5.7.