It started itching from her scalp, all over her hair, behind her neck.Now it's all over the body; it's super bad itch,it went into her eardrum and all over her ear;chest, thigh, and stomach; everything was so red, It was on her neck, chest, thigh, and stomach; restless leg at night; cannot do her day to day things,cannot wear proper clothing; cannot drive; pain; dandruff or lice; gets rashes from walking; severe hives; This spontaneous case was reported by a consumer and describes the occurrence of URTICARIA (severe hives), PRURITUS (It started itching from her scalp, all over her hair, behind her neck.Now it's all over the body; it's super bad itch,it went into her eardrum and all over her ear;chest, thigh, and stomach), ERYTHEMA (everything was so red, It was on her neck, chest, thigh, and stomach), LIMB DISCOMFORT (restless leg at night) and LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (cannot do her day to day things,cannot wear proper clothing) in a 41-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 068H21A, 042B21A and 044A21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     The patient's past medical history included Slipped disc. Concurrent medical conditions included Dermatographia and Low back pain (lower back pain when she took Zyrtec).   On 17-Mar-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 14-Apr-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 23-Dec-2021, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 01-Jan-2022, the patient experienced URTICARIA (severe hives). On an unknown date, the patient experienced PRURITUS (It started itching from her scalp, all over her hair, behind her neck.Now it's all over the body; it's super bad itch,it went into her eardrum and all over her ear;chest, thigh, and stomach), ERYTHEMA (everything was so red, It was on her neck, chest, thigh, and stomach), LIMB DISCOMFORT (restless leg at night), LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (cannot do her day to day things,cannot wear proper clothing), IMPAIRED DRIVING ABILITY (cannot drive), PAIN (pain), DANDRUFF (dandruff or lice) and RASH (gets rashes from walking). The patient was treated with DIPHENHYDRAMINE HYDROCHLORIDE (BENADRYL [DIPHENHYDRAMINE HYDROCHLORIDE]) at a dose of UNK UNK, bid; PREDNISONE from 03-Jan-2022 to 07-Jan-2022 at a dose of 20 milligram; PREDNISONE from January 2022 to January 2022 at a dose of 40 milligram; CETIRIZINE HYDROCHLORIDE (ZYRTEC [CETIRIZINE HYDROCHLORIDE]) at a dose of UNK UNK, tid; FEXOFENADINE HYDROCHLORIDE (ALLEGRATAB) in February 2022 at an unspecified dose and frequency; FAMOTIDINE (PEPCID [FAMOTIDINE]) at an unspecified dose and frequency; HYDROXYZINE HCL at a dose of 10 milligram once a day and HYDROCORTISONE at an unspecified dose and frequency. At the time of the report, URTICARIA (severe hives), PRURITUS (It started itching from her scalp, all over her hair, behind her neck.Now it's all over the body; it's super bad itch,it went into her eardrum and all over her ear;chest, thigh, and stomach), ERYTHEMA (everything was so red, It was on her neck, chest, thigh, and stomach) and RASH (gets rashes from walking) had not resolved and LIMB DISCOMFORT (restless leg at night), LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (cannot do her day to day things,cannot wear proper clothing), IMPAIRED DRIVING ABILITY (cannot drive), PAIN (pain) and DANDRUFF (dandruff or lice) outcome was unknown.            No concomitant medications were reported.  Patient received Benadryl, prednisone but it didn't help her at all. On 10-Jan-2022, patient saw dermatologist, who told her to take three Zyrtec a day and another sleep medicine. She was restless. Zyrtec was giving her so much tiredness, lower back pain, and stomach pain. On an unknown date in Feb-2022 (last week from date of this report), patient switched to Allegra. because the Zyrtec was making her tired. She stated it was a nightmare because she was having withdrawals from Zyrtec. She stated she had never been allergic to anything and never got hives in her life. She was really frustrated because it's been 7 weeks. She was on a low histamine diet. If she eats nuts, avocadoes, spinach, and tomatoes, then they trigger the hives. She was able to have coconut milk, cereal, and oatmeal. She did not have meat or fish. She still takes some antihistamine sometimes. She was supposed to study for an exam, but she could not focus. The medication made her so drowsy. The nights were so bad. She drank 3-4 gallons of water and coconut water. She kept herself hydrated and moisturized. She could not wear proper clothing. It's itching. She gets pain; she was unable to do physical therapy. She used to walk 20-30 minutes every day. Sometimes walking gives her rashes because she's wearing clothes outside. She could not take shower every day because it's so bad. Taking hot shower was so bad because she had to be in front of a fan or take a lot of moisturizers to calm down the rash on her body. She was crying every day. The patient used coconut oil on her scalp in the beginning because she didn't know if it was dandruff or lice.