heart attack that her doctors beleive was due to a spontaneous coronary artery dissection in Right coronary artery; blood clot; Coronary artery dissection; This is a spontaneous report from a contactable other health care professional. This nurse reported for a female consumer (patient). A 45-year-old female patient received BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE, Solution for injection. Batch/Lot number was not reported), dose 2 via an unspecified route of administration on Mar2021 as DOSE 2, SINGLE for COVID-19 immunization. Historical vaccine included: first dose of BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE, Solution for injection) as dose 1, single for COVID-19 immunization. The patient medical and concomitant medication history were reported. Other products and patient history: not provided. Investigation assessment: no. After turning 45 years old on Monday, on Wednesday patient had a heart attack that her doctors believe was due to a spontaneous coronary artery dissection in Right coronary artery that then led to a blood clot. Doctors could not find any possible reason why this could have occurred. Pristine clear from cardiac cath., no other vascular issues and no connective tissue disorders, Could this have been a side effect from the vaccine. The patient get a third booster dose 8 months after the second dose of the Pfizer BioNTech COVID-19 vaccine? On 18Aug2021 it was mentioned that, Caller states that she has called the CDC, FDA, Health Department, and VAERS, and no one can answer question. States that patient knows the simple side effects of the vaccine, but patient needs to know the more specific adverse events that have been reported. It was reported that, she has a very close friend who just had a coronary artery dissection and then due to blood clots she had a heart attack at the age of 45. They scanned and did every test possible and they weren't able to find a reason for it. States that patient knows blood clots could be a possible side effect of COVID and even of the vaccine, but patient did not know if the coronary artery dissection was a possible side effect. Patient wants to know if there have been any reports of coronary artery dissection or heart attack after receiving the vaccine. They are thinking that patient had the coronary artery dissection first, then body formed clots to try to heal that, body occluded and patient had a heart attack. When the doctor did cath. doctor said patient had no blockages. Caller states that patient cholesterol was normal, BMI was perfect, exercises regularly, patient was vegan, patient was perfectly healthy so there was no reason for this to have happened. Caller states that she was a big supporter of the vaccine, she was just trying to figure out if this was could be a potential side effect so she can potentially help others. Her friend is also questioning should she do the booster when it becomes available. Caller states patient knows about myocarditis and pericarditis as potential side effects, but what about heart attacks. caller unwilling to complete the report and declined to provide any further contact information. The patient underwent lab tests and procedures which included blood cholesterol: normal. Body mass index: perfect. Laboratory test: good. Thrombosis: right coronary artery that then led to a blood clot. The outcome of the events were unknown.  The lot number was not provided. Information on lot number has been requested during follow up.; Sender's Comments: Based on the information in the case report and a plausible temporal relationship, a possible causal relationship between the events MI, Coronary artery dissection ,Thrombosis and suspect drug BNT162B2 cannot be excluded The impact of this report on the benefit/risk profile of the Pfizer product is evaluated as part of Pfizer procedures for safety evaluation, including the review and analysis of aggregate data for adverse events. Any safety concern identified as part of this review, as well as any appropriate action in response, will be promptly notified to regulatory authorities, Ethics Committees, and Investigators, as appropriate.