Fever; Nausea; flu-like symptoms; Sore Arm; Blisters / water-like blisters all around neck on both sides all over back, upper arms mostly with two below elbow, upper legs but not below knee, and two blisters on buttocks; itchy blister; Trouble Breathing; Chest Tightness; Achy Body; trouble sleeping; This case was reported by a consumer via call center representative and described the occurrence of fever in a 58-year-old female patient who received Herpes zoster (Shingrix) for prophylaxis.   Previously administered products included Zostavax (received at 50 years age and had no complications following vaccination). Concurrent medical conditions included type i diabetes mellitus (for 44 years).   On 31st October 2019, the patient received the 1st dose of Shingrix. On 1st November 2019, 1 days after receiving Shingrix, the patient experienced fever, nausea, influenza-like symptoms, pain in arm, blister, pruritus, difficulty breathing, chest tightness, general body pain and difficulty sleeping. The patient was treated with ibuprofen and benadryl (nos) (Benadryl). On 1st November 2019, the outcome of the fever, nausea and difficulty breathing were recovered/resolved. On an unknown date, the outcome of the influenza-like symptoms, pruritus, general body pain and difficulty sleeping were unknown and the outcome of the pain in arm and blister were not recovered/not resolved and the outcome of the chest tightness was recovered/resolved.   It was unknown if the reporter considered the fever, nausea, influenza-like symptoms, pain in arm, blister, pruritus, difficulty breathing, chest tightness, general body pain and difficulty sleeping to be related to Shingrix.  Additional case details were reported as follows: The patient receiving Zostavax when she was 50 years old and had no complications following vaccination. The patient received Shingrix vaccine in left arm. The patient woke up the next morning after vaccination with 101 fever, grade 3 sore arm, flu-like symptoms described as body aches and nausea. The patient taking ibuprofen for fever and then sleeping for an additional 2 hours. After waking up the second time, patient reported eating something, fever reduced to 99.8 and then 1 hour later feeling less nauseous due to eating something and overall feeling better. Severe soreness in arm caused trouble sleeping due to not being able to sleep on it. The patient reported the severe soreness decreased on 3rd November 2019 around 1 pm, but it was still tender. On 1st November 2019, Friday night the patient reported walking up a hill outside where temperature reported to be approximately 30 degrees Fahrenheit to return to destination and experienced unusual tightness in chest and trouble breathing although considered to be physically fit.  The next night patient reported walking back same area but took it very slow and had no complaints. On 1st November 2019, Friday night patient taking a shower and noticed water-like blisters all around neck on both sides, all over back, upper arms mostly with two below elbow, upper legs but not below knee, and two blisters on buttocks. The patient described blisters as water-like and itchy, and taking Benadryl. The patient was driving and unable to search for pharmacy contact information. The patient reported being a type 1 diabetic for 44 years and blood glucose being very well controlled other than a slight spike around August. The reporter consent to follow up. This is 1 of the 2 linked cases reported by the same reporter.