Percocet 5/325, that he took the day of shot, may have an interaction; blood pressure spiked to 140/120 or in the 110 range; severe headache; This is a spontaneous report from a contactable consumer (patient). A 74-year-old male patient received the first dose of BNT162B2 (Pfizer-BioNTech COVID-19 vaccine, lot number: EM98909), intramuscular, administered into left shoulder in the muscle on 05Feb2021 at a single dose for COVID-19 immunization and acetylsalicylic acid, oxycodone hydrochloride, oxycodone terephthalate (PERCOCET-5, also reported as Percocet 5/325, lot number: EM9809), via an unspecified route of administration on 05Feb2021 to an unspecified date, at an unspecified dose for an unspecified indication. Medical history included arthritis, blood cholesterol abnormal (taking atorvastatin for cholesterol control), muscle disorder (taking methocarbamol as muscle relaxer), severe problems with nerves in the back which occurred 4-5 years ago, cardiac problems, kidney problems, back problems, chest pain and had stents placed all from unknown dates and major back surgery 2 years ago. Concomitant medications included diclofenac (manufacturer unknown) for arthritis and has been taking for 2-3 years, amlodipine (manufacturer unknown) for blood pressure and has been taking for a year, atorvastatin (manufacturer unknown) for cholesterol control which the patient started 2-3 years ago and methocarbamol (manufacturer unknown) as a muscle relaxant which the patient has been taking for a year. The patient reported that he received the first dose on 05Feb2021 and around 08Feb2021 or 09Feb2021, his blood pressure spiked and he developed a headache. His blood pressure spiked to 140/120 or in the 110 range. His blood pressure usually stays low. He also had a severe headache. He discovered on the day of the report and typed in interaction with drugs and realized that Percocet 5/325, that he took the day of shot, may have an interaction. He took one and shortly after that, he got a really bad headache and blood pressure. He had to call pain his medication group and changed his medication to straight 5 mg Oxycodone. He had major back surgery 2 years ago. He is off everything until the acetaminophen is out of his system for a few days. The patient also stated that since an unspecified date (reported as 'last Jan') he doesn't get flu shots because they use eggs. For this reason, in January of each year, he turns into a mole until June. He is tired of staying in the house and does not like to get out. He thinks the vaccine is only good for 90-120 days and wants to find out. He had to fight to get in to get the vaccine. Waiting 21 days doesn't make it any better because the new strain of the virus is coming around again. He looked over paperwork for effectiveness for the vaccine or antibodies, and it said it is for 90 days.  He would like to know if it goes any further than 90 days. Most vaccines last 5-10 years. He will need to get an opinion on getting second dose after he sees cardiology. The patient received treatment for the event blood pressure spiked to 140/120 or in the 110 range. The outcome of the event blood pressure spiked to 140/120 or in the 110 range and severe headache was recovering while the outcome of the event percocet 5/325, that he took the day of shot, may have an interaction was unknown.