Obesity; HO proteinuria syndrome; sleep apnea; coronary artery disease; Carpal tunnel syndrome; Hypercholesteremia; Vitamin B 12 deficiency; wheezing; Diarrhea; Polycythemia; Diabetes mellitus; Hypertension; Hyperlipidemia; Cough; Anemia; Low vitamin D level; This case was reported by a physician via patient support programs and described the occurrence of type ii diabetes mellitus in a 53-year-old male patient who received Flu Seasonal QIV Dresden (Influenza vaccine Quadrivalent 2016-2017 season) for prophylaxis.   The patient's past medical history included bypass surgery, coronary stent placement and sleeve gastrectomy. Concurrent medical conditions included gastric bypass, leg pain and smoker (current every day smoker). Concomitant products included nitroglycerine (Nitroglycerin), omeprazole, ergocalciferol (Vitamin D2), isosorbide mononitrate, cyanocobalamin, minerals nos + vitamins nos (Integra), insulin lispro (Humalog), metoprolol tartrate, temazepam, lovastatin, tylenol #1 (nos) (Tylenol Codeine #1), lisinopril, dapagliflozin propanediol + metformin hydrochloride (Xigduo Xr), sitagliptin (Januvia) and insulin glargine (Lantus).   On 3rd October 2016, the patient received the 1st dose of Influenza vaccine Quadrivalent 2016-2017 season. On 28th October 2016, 25 days after receiving Influenza vaccine Quadrivalent 2016-2017 season and an unknown time after starting omeprazole, Vitamin D2, isosorbide mononitrate and cyanocobalamin, the patient experienced anemia and vitamin d low. On 11th January 2017, the patient experienced type ii diabetes mellitus (serious criteria GSK medically significant), hypertension, hyperlipidemia and cough. On 30th August 2017, the patient experienced polycythemia. On 31st August 2017, the patient experienced diarrhea. On an unknown date, the patient experienced obesity, proteinuria, sleep apnea, coronary artery disease, carpal tunnel syndrome, hypercholesterolemia, vitamin b12 deficiency and wheezing. On an unknown date, the outcome of the type ii diabetes mellitus, obesity, proteinuria, sleep apnea, coronary artery disease, carpal tunnel syndrome, hypercholesterolemia, vitamin b12 deficiency, anemia, vitamin d low, wheezing, hypertension, hyperlipidemia, cough, diarrhea and polycythemia were unknown.   It was unknown if the reporter considered the type ii diabetes mellitus, obesity, proteinuria, sleep apnea, coronary artery disease, carpal tunnel syndrome, hypercholesterolemia, vitamin b12 deficiency, anemia, vitamin d low, wheezing, hypertension, hyperlipidemia, cough, diarrhea and polycythemia to be related to Influenza vaccine Quadrivalent 2016-2017 season.  Additional details were provided as follows: The patient did not have known drug allergies. The patient was a large man in no stress and his neck shown no lymph node swelling. His lungs shown diminished breath sounds without wheezing. The patient had no chest pain or precordial discomfort. No headaches or dizziness, no neck pain and no abdominal pain. The patient's heart rhythm was regular with no headache or dizziness, no neck pain and no abdominal pain. The also received Anoro and would continue same. After receiving Influenza vaccine, the patient experienced diabetes mellitus, obesity, proteinuria, sleep apnea, coronary artery disease, carpal tunnel syndrome, hypercholesterolemia and vitamin b12 deficiency. On an unknown date, the outcome of the diabetes mellitus, obesity, proteinuria, sleep apnea, coronary artery disease, carpal tunnel syndrome, hypercholesterolemia, vitamin b12 deficiency, anemia and vitamin d low . This was 1 of 4 linked cases, reported for same patient.; Sender's Comments:  US-GLAXOSMITHKLINE-US2020AMR176911:Influenza 2016-2017 US-GLAXOSMITHKLINE-US2020AMR176890:same patient US-GLAXOSMITHKLINE-US2020AMR176926:same patient