Chills; experienced an allergic reaction to the second booster dose; nose membranes felt like they were "set fire" and bad; couldn't move her joints / couldn't move her ankles; something wrong in back of throat; felt extremely tired, feels tired today/ felt tired all day; bad joint aches and pain / her joints continued to hurt; right arm hurt/ tips of toes were in pain; Headache; skin hurt (couldn't touch it), skin still hurt; body aches felt like flu; This spontaneous case was reported by a consumer and describes the occurrence of PAIN OF SKIN (skin hurt (couldn't touch it), skin still hurt), INFLUENZA LIKE ILLNESS (body aches felt like flu), NASAL DISCOMFORT (nose membranes felt like they were "set fire" and bad), MUSCULOSKELETAL DISCOMFORT (couldn't move her joints / couldn't move her ankles) and OROPHARYNGEAL DISCOMFORT (something wrong in back of throat) in a 75-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch no. 056A22A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     The patient's past medical history included Cancer (Cancer Survivor. No recent change reported) and Polyp removal (Precancerous polyps removed No recent change reported). Concurrent medical conditions included Seasonal allergy, Multiple allergies, Fruit allergy (grape's allergy) and Drug allergy (Allergic to the colonoscopy "Prep" medication). Concomitant products included VITAMINS NOS, VITAMIN D NOS and CYANOCOBALAMIN (VITAMIN B-12) for an unknown indication.    On 03-May-2022, the patient received fourth dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) .25 milliliter. On 03-May-2022, the patient experienced PAIN OF SKIN (skin hurt (couldn't touch it), skin still hurt), INFLUENZA LIKE ILLNESS (body aches felt like flu), MUSCULOSKELETAL DISCOMFORT (couldn't move her joints / couldn't move her ankles), OROPHARYNGEAL DISCOMFORT (something wrong in back of throat), FATIGUE (felt extremely tired, feels tired today/ felt tired all day), ARTHRALGIA (bad joint aches and pain / her joints continued to hurt), PAIN IN EXTREMITY (right arm hurt/ tips of toes were in pain) and HEADACHE (Headache). On 04-May-2022, the patient experienced NASAL DISCOMFORT (nose membranes felt like they were "set fire" and bad). On 05-May-2022, the patient experienced HYPERSENSITIVITY (experienced an allergic reaction to the second booster dose). On an unknown date, the patient experienced CHILLS (Chills). The patient was treated with PARACETAMOL (TYLENOL) at a dose of 500 milligram; NAPROXEN SODIUM (ALEVE) for Throat discomfort and Headache, at an unspecified dose and frequency and FEXOFENADINE HYDROCHLORIDE (ALLEGRA [FEXOFENADINE HYDROCHLORIDE]) for Throat discomfort and Headache, at an unspecified dose and frequency. On 04-May-2022, OROPHARYNGEAL DISCOMFORT (something wrong in back of throat) and HEADACHE (Headache) had resolved. On 05-May-2022, CHILLS (Chills) had resolved. At the time of the report, PAIN OF SKIN (skin hurt (couldn't touch it), skin still hurt), INFLUENZA LIKE ILLNESS (body aches felt like flu), NASAL DISCOMFORT (nose membranes felt like they were "set fire" and bad), MUSCULOSKELETAL DISCOMFORT (couldn't move her joints / couldn't move her ankles), ARTHRALGIA (bad joint aches and pain / her joints continued to hurt), PAIN IN EXTREMITY (right arm hurt/ tips of toes were in pain) and HYPERSENSITIVITY (experienced an allergic reaction to the second booster dose) was resolving and FATIGUE (felt extremely tired, feels tired today/ felt tired all day) had not resolved.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): In September 2021, SARS-CoV-2 test: negative (Negative) Tested negative in September 2021.         Patient did not receive other vaccines within 1 month prior to Moderna COVID-19 vaccine. The  patient experienced events. Patient experienced the worse reaction to the second booster dose compared to the other previous doses. It stated patient took Aleve and her body felt much better. She reported the back of throat problem and headache went away after taking Aleve and Allegra, however Tylenol didn't help her. On 05-May-2022, patient reported she feels 90% better. She mentioned taking the Aleve and Allegra was the key to feeling better.   This case was linked to MOD-2022-559967, MOD-2022-559985, MOD-2022-559986.