PAIN; BP DROPPED; REALLY HIGH BLOOD PRESSURE; DIMINISHED REFLEXES; DEPRESSED; COMPLETELY DISABLED; This spontaneous report received from a consumer concerned a 54 year old male. The patient's height, and weight were not reported. The patient's concurrent conditions included: blood pressure high (high/ normal). Patient was usually very healthy. The patient was previously treated with testosterone. The patient received covid-19 vaccine ad26.cov2.s (suspension for injection, route of administration not reported, batch number: 043A214, expiry: UNKNOWN) dose was not reported, 1 total administered on 15-MAY-2021 around late morning to early afternoon to left deltoid for prophylactic vaccination. No concomitant medications were reported. On 30-MAY-2021, 2 weeks after vaccination, patient became immediately and completely disabled. On 01-JUN-2021, he went to a clinic as he experienced so much pain and he received pain medication but was not sure what it was called. He went home and they were not really able to help him. He has been to multiple emergency room (ER) hospitals, doctor visits and several neurologists. The reporter does not have exact dates and stated would provide the information later. The initial tests were all subjective. He also went to a pain management specialist to try to get the pain under control. The pain management doctor recommended spinal tap and magnetic resonance imaging (MRI). He was in the hospital for a week trying to get these test done, and no one actually performed these tests. The spinal tap machine was broken and when he went to do the MRI, they tried to do the MRI on his brain instead of his spine. The patient just left and did not have either of the test done. He got his reflexes tested. His reflexes had been diminished, but were still there. A lot of doctors said he did not have Guillain Barre Syndrome (GBS) as he still had his reflexes. He received different opinion from multiple doctors regarding having and not having GBS. Then he was prescribed for a lumbar puncture spinal tap to be done. He then struggled to walk and had a cane. He had lab results from the spinal tap, once it was finally done. He did not want to go back to the ER unless someone in the hospital knew he was coming, and they put him in the right place, as they did not give him pain medications, and it was a poor basic care, otherwise. He had a lot of trouble getting down the stairs and into the car. He was depressed. He also had really high blood pressure (BP) since this started that he was having trouble controlling it. BP stayed too high most of the time and one day it dropped to 70/40 mmHG. The action taken with covid-19 vaccine ad26.cov2.s was not applicable. The patient had not recovered from completely disabled, pain, really high blood pressure, diminished reflexes, and bp dropped, and the outcome of depressed was not reported. This report was serious (Hospitalization Caused / Prolonged, and Other Medically Important Condition).; Sender's Comments: V0: 20211033651-covid-19 vaccine ad26.cov2.s-pain, completely disabled, BP dropped. This event(s) is considered unassessable. The event(s) has a compatible/suggestive temporal relationship, is unlabeled, and has unknown scientific plausibility. There is no information on any other factors potentially associated with the event(s).