puffy (3rd dose)/ like a lump on it; arm a little hard; arm sore and puffy (3rd dose); puffy (3rd dose)/ like a lump on it; at night woke up feeling different; at night, more sweaty, body was hot; body was hot/fending off a lot of body heat; This spontaneous case was reported by a consumer and describes the occurrence of FEELING ABNORMAL (at night woke up feeling different), HYPERHIDROSIS (at night, more sweaty, body was hot), FEELING HOT (body was hot/fending off a lot of body heat), VACCINATION SITE MASS (puffy (3rd dose)/ like a lump on it) and VACCINATION SITE INDURATION (arm a little hard) in a 60-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 088B21A and 028A21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     The patient's past medical history included Kidney transplant. Concomitant products included PREDNISONE, BELATACEPT and MYCOPHENOLATE MOFETIL (CELLCEPT [MYCOPHENOLATE MOFETIL]) for Kidney transplant.   On 26-Feb-2021, the patient received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 22-Aug-2021, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On an unknown date, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 22-Aug-2021, the patient experienced FEELING ABNORMAL (at night woke up feeling different), HYPERHIDROSIS (at night, more sweaty, body was hot) and FEELING HOT (body was hot/fending off a lot of body heat). On an unknown date, the patient experienced VACCINATION SITE MASS (puffy (3rd dose)/ like a lump on it), VACCINATION SITE INDURATION (arm a little hard), VACCINATION SITE PAIN (arm sore and puffy (3rd dose)) and VACCINATION SITE SWELLING (puffy (3rd dose)/ like a lump on it). The patient was treated with PARACETAMOL (TYLENOL) for Adverse event, at an unspecified dose and frequency. At the time of the report, FEELING ABNORMAL (at night woke up feeling different), HYPERHIDROSIS (at night, more sweaty, body was hot), FEELING HOT (body was hot/fending off a lot of body heat), VACCINATION SITE MASS (puffy (3rd dose)/ like a lump on it), VACCINATION SITE INDURATION (arm a little hard), VACCINATION SITE PAIN (arm sore and puffy (3rd dose)) and VACCINATION SITE SWELLING (puffy (3rd dose)/ like a lump on it) outcome was unknown.            Patient is immunocompromised, because she had a kidney transplant and is taking immunosuppressive medications. Patients reports that she has not built up any immunity, she has no antibodies at all after receiving her test. She got her blood taken for the spike antibody test, and it came back negative. She also took a test for T cells, and is waiting to get those results to see if she will get a response. She takes Belatacept, an infusion drug, and her nurse said a lot of people do not get immunity when they are on this medication. She takes the infusion every 28 days, and for her third dose, she waited for the 12th day in her cycle to get the shot so she might have more of a chance of developing immunity. She also usually takes Cellcept 2 pills twice a day, but her allergist told herto drop down the dosage of one of her drugs, so she dropped the dosage to 1 pill twice a day so that she might get a response from the vaccine. She reports not getting any antibodies after her 2nd dose either, they think it is because of the Belatacept. She received her third dose in the right arm, does not remember what arm she received the other doses in. Patient reports from first dose, she did not experience any side effects, she felt a little brain foggy, but does not remember anything else. From the 2nd dose, she did not experience any side effects. From the 3rd dose, her arm was sore and puffy, it was a little hard, there was like a lump on it. She reports she had been waking up at night sweating because it was muggy previously, but that night she got the 3rd dose, she woke up and felt different: more sweaty, her body was hot, she was fending off a lot of body heat that she normally does not do.   This case was linked to MOD-2021-345465.