FLU; SICK AS HELL; ONGOING ALLERGY THAT WAS AFFECTING HIS NERVES; BLOOD CLOT/ BLOOD CLOT DRAINED FROM FACE; FACE COMPLETELY BLEW UP; BLISTERS IN THE EYES; EYES BLEW UP / UPPER AND LOWER GLANDS OF THE EYES BECAME SWOLLEN; UPPER AND LOWER GLANDS OF THE EYES BECAME RED; ALLERGY BECAME MORE INTENSE / HYPERALLERGIC TO DUST MITES AND TO DIFFERENT TYPES OF TREES AND GRASS  / IMMUNE SYSTEM WANTS TO ATTACK MY FACE; This spontaneous report received from a patient concerned a 68 year old male. The patient's height, and weight were not reported. The patient's past medical history included: cocaine consumption (Cocaine issue in the eighties but got rid of that.), and concurrent conditions included: HIV (human immunodeficiency virus infection) (HIV positive in 1986 now viral load non detectable), depression, difficult awakening, smoker (Smokes marijuana 3 times a day used to smoke cigarettes but quit in 1993.), alcohol use (moderates 3 beers a day), dust mites allergy, and different trees and grass allergy, and other pre-existing medical conditions included: The patient had drug abuse or illicit drug usage. The patient received covid-19 vaccine ad26.cov2.s (dose number in series 1) (suspension for injection, route of admin not reported, batch number: 202A21A, expiry: UNKNOWN) dose was not reported, 1 total was administered in left arm on 07-APR-2021 for prophylactic vaccination. Age at time of vaccination 68 years old. Concomitant medications included venlafaxine for antidepressant, methylphenidate for difficult awakening, and bictegravir sodium/emtricitabine/tenofovir alafenamide fumarate.  On 16-APR-2021, one week and 2 days after vaccination, patient's face was completely blew up, eyes blew up, eyes had blisters, all glands around the blisters in the eyes, upper and lower parts of the eyes became swollen and red and then all calmed down after about a month but ever since this period stated that has been dealing with allergic reactions to everything. The patient stated immune system was attacking face. The patient had history of allergies but reactions were never this level of intense illness, patient kept stating the he feels sick. On 18-MAR-2022, the patient developed what he referred to as blood blot but there was no clinical diagnosis of blood clot. The patient stated it was developed on his left cheek a cyst fibrous which he scrapped over the top of it and sucked out in an empty shampoo bottle, half the size of patient's palm of blood clot was came out of his face, it was healed right up, was not painful, came right out. The patient saw an ENT (ear nose throat) doctor that recommended an allergy skin test. On 15-APR-2022, two days before reporting, the patient underwent allergy skin test and the result was patient was hyperallergic to dust mites and to different types of trees and grass, not allergic to animals and the recommended treatment might be a weekly injection of allergy medications. The patient stated that he also developed GBS (Guillain-Barre syndrome), when agent asked for more details he stated "nerves are not happy with ongoing reactions". Patient confirmed that there was no clinical diagnosis of GBS and by GBS he was referring that they are ongoing allergy that was affecting his nerves. The patient described his intense allergic reactions that they are ongoing happening every single day as if he had flu every day, no fever. The patient stated he has no vitality that he should have. The patient stated that being HIV positive since the eighties might be contributing to his intense allergic reactions (dose number in series 1).  The patient additionally received non-company Pfizer Biontech covid-19 vaccine (dose number in series 2) (form of administration, route of administration, batch number were not reported, expiry: unknown) dose was not reported, on 17-NOV-2021 for prophylactic vaccination. It was unknown whether patient had any adverse events following vaccination with Pfizer Biontech covid-19 vaccine (dose number in series 2).  The action taken with covid-19 vaccine ad26.cov2.s was not applicable. The patient recovered from blood clot/ blood clot drained from face, face completely blew up, blisters in the eyes, eyes blew up / upper and lower glands of the eyes became swollen, and upper and lower glands of the eyes became red, had not recovered from allergy became more intense / hyperallergic to dust mites and to different types of trees and grass / immune system wants to attack my face, sick as hell, and flu, and the outcome of ongoing allergy that was affecting his nerves was not reported. This report was serious (Other Medically Important Condition).; Sender's Comments: V0:20220432907-Covid-19 vaccine ad26.cov2.s- blood. clot/ blood clot drained from face. The event(s) has a compatible/suggestive temporal relationship, is unlabeled, and has unknown scientific plausibility. There is no information on any other factors potentially associated with the event(s). Therefore, this event(s) is considered unassessable.