3 hours after the shot I was able to move around like I haven't been able to in years; her weight is up from 322 pounds to 330 or 335 pounds. Her weight goes up and down; This is a spontaneous report received from contactable reporter(s) (Other HCP) from medical information team. The reporter is the patient.  A 65 year-old female patient received bnt162b2 (BNT162B2), administered in arm left, administration date 19Jun2021 (Lot number: EW0168) at the age of 65 years as dose 1, single for covid-19 immunisation. Relevant medical history included: "osteoarthritis" (unspecified if ongoing); "fibromyalgia" (unspecified if ongoing); "pulmonary embolism issues" (unspecified if ongoing); "congestive heart failure" (unspecified if ongoing); "trigeminal neurology" (unspecified if ongoing); "Handicap" (unspecified if ongoing); "Fall" (unspecified if ongoing). Concomitant medication(s) included: WARFARIN taken for pulmonary embolism; WARFARIN taken for pulmonary embolism. The following information was reported: THERAPEUTIC RESPONSE UNEXPECTED (non-serious) with onset 19Jun2021, outcome "unknown", described as "3 hours after the shot I was able to move around like I haven't been able to in years"; WEIGHT ABNORMAL (non-serious) with onset 2021, outcome "unknown", described as "her weight is up from 322 pounds to 330 or 335 pounds. Her weight goes up and down". Relevant laboratory tests and procedures are available in the appropriate section.  Additional information: Entered caller was HCP - nurse because she stated she was in the healthcare field as a nurse for 20 years. No longer practicing. Caller, stated, she had positive news. She was handicapped. She had the Pfizer BioNTech covid vaccine first shot on 19JUN Saturday. She have osteoarthritis, fibromyalgia and pulmonary embolism issues (continue to take warfarin for that) 3 hours after the shot she was able to move around like she have not been able to in years. She felt secure in being able to function. She was to report if it would be of help in other way. She was very sensitive to things. She felt like she was the person she was 10 or 11 years ago before she fell." Caller mentioned how she also has trigeminal neurology so she has a lot of pain but after the shot she "was able to move around like she hasn't been able to in years." She was monitoring her symptoms and was looking for the negative things, but wanted to report want happened to her after the shot. Caller was a retired nurse who has some positive effects to report after receiving the first dose of the Pfizer Biontech Covid vaccine. Her first dose was received 19Jun2021. She has a lot of pre-existing conditions like osteoarthritis, fibromyalgia, pulmonary embolism issues. Reporting that three hours after the shot she was able to move around like she has not been able to in years. She felt secure in being able to function. She felt like she was a person that she was 10 or 11 years ago before she fell. She is handicap. When querying weight, reports she has congestive heart failure and has taken on water and her weight is up from 322 pounds to 330 or 335 pounds. Her weight goes up and down. When trying to get her vaccination card out of her wallet states her hands are numb. Indication: because she is so sensitive to medications, she may not get covid herself and someone else may bring it to her and she is getting the vaccine to be prepared.  She has other medical conditions. She gets blood draw for warfarin every two weeks and she will get it drawn next week. There is other medications that she takes and she did not take them before the injection. It was probably after she started to feel good that she took her medication, it was around the same time frame. No further clarification provided. Follow-up attempts are completed. No further information is expected.