temperature excursion due to the refrigerator door being left opened; Initial information received on 31-Jan-2022 regarding an unsolicited valid  non-serious case received from a pharmacist.  This case is linked to case 2022SA036034.  This case involves Adult and unknown gender patient who experienced temperature excursion due to the refrigerator door being left opened while receiving vaccines influenza quadrival a-b high dose hv vaccine [fluzone high-dose quadrivalent], diphtheria-2/tetanus-5 adsorbed toxoids no preservative adult [tenivac] and ipv (vero) [ipol] and while treated with caffeine, chlorphenamine maleate, dextromethorphan hydrobromide, ginger powder, hesperidin, licorice extract, methylephedrine hydrochloride, paracetamol [s. tac general] and althaea officinalis root, cinnamomum camphora essential oil, citrus aurantium oil, eucalyptus globulus leaf essential oil, mentha x piperita essential oil ([gardisil)  The patient's past medical history, medical treatment(s), vaccination(s) and family history were not provided.   On an unknown date, the patient started taking S. TAC GENERAL (CAFFEINE, CHLORPHENAMINE MALEATE, DEXTROMETHORPHAN HYDROBROMIDE, GINGER POWDER, HESPERIDIN, LICORICE EXTRACT, METHYLEPHEDRINE HYDROCHLORIDE, PARACETAMOL) Film-coated tablet dosage unknown (with an unknown batch number) and GARDISIL (ALTHAEA OFFICINALIS ROOT, CINNAMOMUM CAMPHORA ESSENTIAL OIL, CITRUS AURANTIUM OIL, EUCALYPTUS GLOBULUS LEAF ESSENTIAL OIL, MENTHA X PIPERITA ESSENTIAL OIL) formulation unknown dosage unknown (with an unknown batch number). On an unknown date, the patient received a  dose of suspect IPV (VERO) lot T1D481M. On an unknown date, the patient received a  dose of suspect DIPHTHERIA-2/TETANUS-5 ADSORBED TOXOIDS NO PRESERVATIVE ADULT lot U6603AA.Exp.date: 05MAR2022 On an unknown date, the patient received a  dose of suspect INFLUENZA QUADRIVAL A-B HIGH DOSE HV VACCINE lot UJ765AB.  On an unknown date the patient developed a non-serious event " temperature excursion due to the refrigerator door being left opened"  (product temperature excursion issue) (unknown latency) following the first dose intake  CAFFEINE, CHLORPHENAMINE MALEATE, DEXTROMETHORPHAN HYDROBROMIDE, GINGER POWDER, HESPERIDIN, LICORICE EXTRACT, METHYLEPHEDRINE HYDROCHLORIDE, PARACETAMOL, (unknown latency) following the first dose intake of ALTHAEA OFFICINALIS ROOT, CINNAMOMUM CAMPHORA ESSENTIAL OIL, CITRUS AURANTIUM OIL, EUCALYPTUS GLOBULUS LEAF ESSENTIAL OIL and MENTHA X PIPERITA ESSENTIAL OIL and  following the administration of IPV (VERO), (unknown latency) ,DIPHTHERIA-2/TETANUS-5 ADSORBED TOXOIDS NO PRESERVATIVE ADULT and (unknown latency) and of INFLUENZA QUADRIVAL A-B HIGH DOSE HV VACCINE.  it was reported " reporting a temperature excursion due to the refrigerator door being left opened resulting in the blower operating continuously causing a low temperature excursion. Caller reporting FLUZONE HIGH-DOSE QUADRIVALENT, GARDISIL, IPOL, and TENIVAC at a low of 0.5C for 405 minutes. Caller unsure if any opened IPOL MDVs. See related case #: 00957378TENIVAC Lot#: U6603AA, Exp.date: 05MAR2022 No further information provided by the reporter. This is reported as potential AE because of temperature excursion. To be evaluated. Reporter relationship : HCP Product used : Not Applicable"  Action taken with  poliomyelitis vaccine (inactivated) (ipol), diphtheria and tetanus toxoids (tenivac), althaea officinalis root, cinnamomum camphora essential oil, citrus aurantium oil, eucalyptus globulus leaf essential oil, mentha x piperita essential oil (gardisil) and quadrivalent influenza vaccine (fluzone high-dose quadrivalent) was unknown. action taken with caffeine, chlorphenamine maleate, dextromethorphan hydrobromide, ginger powder, hesperidin, licorice extract, methylephedrine hydrochloride, paracetamol (s. tac general) was not applicable.   It was not reported if the patient received a corrective treatment for the event (temperature excursion due to the refrigerator door being left opened).  At time of reporting, the outcome was Unknown for the event temperature excursion due to the refrigerator door being left opened.