Depression/Severe depression; Body weakness; Dizziness; Falling; severe weakness in my arms and legs; she can barely walk; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP) from medical information team, Program ID.  A 65-year-old female patient received BNT162b2 (BNT162B2), on 03Dec2021 as dose 3 (booster), single (Lot number: 33030BD) at the age of 65 years for covid-19 immunisation. The patient's relevant medical history included: "Thyroid issues" (unspecified if ongoing); "Defibrillator/pacemaker insertion" (unspecified if ongoing); "muscular dystrophy" (unspecified if ongoing), notes: she had muscular dystrophy; "Parkinson's" (unspecified if ongoing), notes: Parkinson's. Concomitant medication(s) included: CLONAZEPAM; ALPRAZOLAM. Vaccination history included: BNT162b2 (First Dose, Lot EN6199), administration date: 05Mar2021, when the patient was 65-year-old, for COVID-19 immunization, reaction(s): "Severe depression", "Body is weak in the leg, arms, hands/ weakness", "She can barely walk", "Falling several times", "Dizziness"; BNT162b2 (Second Dose, Lot ER8733), administration date: 26Mar2021, when the patient was 65-year-old, for COVID-19 immunization, reaction(s): "Dizziness", "Falling several times", "Severe depression", "She can barely walk", "Body is weak in the leg, arms, hands/ weakness". The following information was reported: DEPRESSION (non-serious), outcome "not recovered", described as "Depression/Severe depression"; ASTHENIA (non-serious), outcome "not recovered", described as "Body weakness"; DIZZINESS (non-serious), outcome "not recovered"; FALL (non-serious), outcome "not recovered", described as "Falling"; MUSCULAR WEAKNESS (non-serious), outcome "unknown", described as "severe weakness in my arms and legs"; GAIT DISTURBANCE (non-serious), outcome "not recovered", described as "she can barely walk". Relevant laboratory tests and procedures are available in the appropriate section.  Additional Information: Daughter which is the caregiver for her mom wanted to know if the onset of depression, body weakness, dizziness and falling were related to the vaccine. Reporter then stated being interested in knowing if there was anything to do to reverse the side effects and how long the vaccine stays in the system. Ever since she has gotten it or actually every time she has gotten each dose, she experiences severe depression, her body is weak in the leg, arms, hands to the point she can barely walk and is falling several times. She also experiences dizziness each time, between the dizziness and weakness she has fallen a few times because of it. Caller is wondering if there is anything she can do to reverse the side effects or help. Caller states that her mom has had 5 doses of the COVID vaccine and all of them are Pfizer. Third Dose: Date 03Dec2021 Lot is either 33030BD or 33030DD. The reporter clarified that only the Fifth dose was the Pfizer COVID Bivalent Vaccine. The Fifth dose was the worst for her as of side effects. Doses One to Four were the Monovalent COVID Vaccine. Caller also clarified that each time with each dose, with the last dose being the worst, but each time her mom would experience Depression, Body weakness, and dizziness. She was 65 when she got her first dose, she is 66 at the moment. During the call, caller's mom withheld says she thought she had muscular dystrophy or something like that. The Dizziness is on and off, it is not constant. The side effects happen with each vaccination, however the start of the side effects typically started a few days after getting the vaccine and gets worse. Investigation: She recently had a brain scan clarifying it was actually a CT scan of the brain, back and neck. She also had labs done since she is suppose to be having her hip replaced next Friday. The CT scans results had nothing, when it came back, besides showing that she has some deterioration in the hips. For the labs, she recalls is was Blood work and they did a bacterial swab, she cant remember what bacteria she was positive for but she had an infection, The CT scans and lab work was back in Sep2022 she is guessing since the doctor appointment was in early Oct2022. The patient had no allergies. Reporter states that her mom asked the doctor if she had muscular dystrophy, the doctor ruled that out, the doctor also said Parkinson's is ruled out, He ruled out all of that and said its not what it is, they don't know what it was, but just noticed it comes on every time she gets the covid vaccines. Furthermore, it was reported that Since patient started the vaccine, she overcome with depression, dizziness, and severe weakness in her arms and legs. She have fallen many times due to the weakness and dizziness. She received her last dose of the Pfizer vaccine on Wednesday 26Oct. The next day her depression was out of control and she could hardly walk. She came to realize it was the vaccine causing her problems.; Sender's Comments: Linked Report(s) : US-PFIZER INC-202201296028 Same patient, different dose and event.;