swelling in fingers; HCP believed it was a systemic allergic reaction to something/histamine response/symptoms seems to have stagnated in going away; severe itching on head/advanced to severe itching all over body at different time in different places/raised back of neck/very itchy back of neck/itching raging all over her body/still gets itching on top ofhands/stripes itching down back/both elbows; swelling in back of neck/swollen back of neck; redness/red back of neck/red strips/redness raging all over her body/still gets redness on top of hands; Pain; This spontaneous case was reported by a consumer and describes the occurrence of PRURITUS (severe itching on head/advanced to severe itching all over body at different time in different places/raised back of neck/very itchy back of neck/itching raging all over her body/still gets itching on top ofhands/stripes itching down back/both elbows), SWELLING (swelling in back of neck/swollen back of neck), ERYTHEMA (redness/red back of neck/red strips/redness raging all over her body/still gets redness on top of hands), PAIN (Pain) and HYPERSENSITIVITY (HCP believed it was a systemic allergic reaction to something/histamine response/symptoms seems to have stagnated in going away) in a 65-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 939906, 029A21A and 028A21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     No medical history was provided by the reporter.  Concomitant products included IMIPRAMINE for an unknown indication.   On 03-Mar-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 31-Mar-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 22-Oct-2021, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to .25 milliliter. On 01-Nov-2021, the patient experienced PRURITUS (severe itching on head/advanced to severe itching all over body at different time in different places/raised back of neck/very itchy back of neck/itching raging all over her body/still gets itching on top ofhands/stripes itching down back/both elbows), SWELLING (swelling in back of neck/swollen back of neck), ERYTHEMA (redness/red back of neck/red strips/redness raging all over her body/still gets redness on top of hands) and PAIN (Pain). On 03-Nov-2021, the patient experienced HYPERSENSITIVITY (HCP believed it was a systemic allergic reaction to something/histamine response/symptoms seems to have stagnated in going away). On 03-Dec-2021, the patient experienced PERIPHERAL SWELLING (swelling in fingers). The patient was treated with PREDNISONE for Adverse event, at a dose of 2 days of 50 mg, 2 days of 40mg, 1 day of 30mg; HYDROXIZINE HCL for Adverse event, at a dose of 10mg at night and CETIRIZINE HYDROCHLORIDE (ZYRTEC ALLERGY) for Adverse event, at a dose of twice a day for two weeks, then once a day for another 2 days. At the time of the report, PRURITUS (severe itching on head/advanced to severe itching all over body at different time in different places/raised back of neck/very itchy back of neck/itching raging all over her body/still gets itching on top ofhands/stripes itching down back/both elbows), SWELLING (swelling in back of neck/swollen back of neck), ERYTHEMA (redness/red back of neck/red strips/redness raging all over her body/still gets redness on top of hands), PAIN (Pain), HYPERSENSITIVITY (HCP believed it was a systemic allergic reaction to something/histamine response/symptoms seems to have stagnated in going away) and PERIPHERAL SWELLING (swelling in fingers) had not resolved.        For mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular), the reporter did not provide any causality assessments.   This case was linked to MOD-2021-404634, MOD-2021-404689 (Patient Link).