fatigue; headache; anxiety issues; has lost 12-13lbs; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP) from medical information team.  A 54 year-old female patient received bnt162b2 (BNT162B2), administered in arm left, administration date 05Apr2021 (Lot number: EW0151) at the age of 54 years as dose 1, single for covid-19 immunisation. Relevant medical history included: "thyroid" (unspecified if ongoing), notes: Caller explains his wife takes thyroid medication, clarified as Synthroid. Concomitant medication(s) included: SYNTHROID taken for thyroid disorder. The following information was reported: FATIGUE (non-serious) with onset 2021, outcome "unknown", described as "fatigue"; HEADACHE (non-serious) with onset 2021, outcome "unknown", described as "headache"; ANXIETY (non-serious) with onset 2021, outcome "unknown", described as "anxiety issues"; WEIGHT DECREASED (non-serious) with onset 2021, outcome "unknown", described as "has lost 12-13lbs". Relevant laboratory tests and procedures are available in the appropriate section.  Additional information: As per caller his wife received 3 doses of the vaccine: 1st 05Apr2021, 2nd 26Apr2021 and 3rd 26Aug2021. "After the first and second dose, she had fatigue, headache, anxiety issues. After the 3rd dose (1-2 weeks later) she could not eat, headache, tightness of neck, anytime she would eat her blood sugar would go up to 250-260 and 20-30min later would go down to 40-60 and would have fainting spells. My 16 year old son was with her at the time an they had to take her to the Emergency Room a couple of times. She is still having this issue, she is not able to eat any carbs or rice,  bread or any sugar. She can only have oatmeal and this has caused her to loose a lot of weight because everything leads to sugar highs and lows. She didn't have this before, she has no family history of diabetes. Yesterday we read information online and people are pointing towards sugar issues related to the vaccine, some people became diabetic, or hypoglycemia issues, some are on insulin. They are still doing tests, she will have a stomach imaging tomorrow, they did an endoscopy and did allergy test we have seen many doctors. My wife never took diabetes meds before. The caller states he is calling on behalf of his wife in regards to the Pfizer vaccine for COVID. The caller is reports that she has been having a lot of adverse problems. Healthcare Professional: The caller provides the doctor he states his wife has been seeing at the hospital when she had some issues. He clarifies his wife has seen several doctors but this doctor attended her when she went to the ER. No further contact information was known. The caller states he went online and tried to fill out the VAERS form  but every time he filled it and went to submit, it always gave him an error. He mentions he had the Moderna shots and his wife had the Pfizer shots. Caller explains after his wife took the first shot, a couple of weeks later, she was feeling uneasiness. She had fatigue, headache, anxiety, and all of that. However, they didn't really pay attention to it, they thought it just may be something and didn't attach it to being from the vaccine. As time went on, she took the second shot and she was still feeling fatigue after that. A lot of people told her, she would feel fatigue for a couple of months and this and that as she was talking to people in the area. However, after she took the third shot, his wife really started having headaches and fainting spells. Caller clarifies his wife started fainting and after that her anxiety got much worse. She had severe headaches, tightness in her neck area. And then, she had sugar problems. Every time, she ate something, her sugar went through the roof. When she would eat some rice, her sugar would go up to 250-260 then within the next 20-30 minutes, her sugar would go down to 40 or 50. Caller states ever since she received the third dose she is having issue after issue with her sugar. She is not able to eat regular meals. Caller states his wife has been hospitalized 3 times. Caller mentions he was away so his 16-year-old son had to take her to the ER 3 times. The caller clarifies she is still having tests run. She was told she had hypoglycemia. His wife never had any sugar issues and never took any medicine for sugar or had any other problems with her sugar prior to the vaccines. His wife was pretty healthy and was going to gym all the time prior to the COVID vaccine. Ever since these vaccines, she has started to have fatigue and has lost 12-13lbs over the last few months because she has not been able to eat. The caller explains they have taken her to so many doctors including an Endocrinologist and GI doctors. She is still having tests run. They took his wife to (withheld) where their daughter is a doctor their and she was taking to RA which is a hospital there. His wife has also been to the hospital in (withheld). She has another test next week clarified as an ultrasound of her stomach. All of the test are coming back with her being hypoglycemic. She is not able to eat normal meals. The only thing she is having to eat in the morning is oatmeal and even at night, she will eat oatmeal. She cannot take any juices or have any normal meals. She can't even eat rice. The caller explains he was calling today because he is trying to get help on what can they do. The main problem she is having is the sugar issue. Any time, she eats something, her sugar goes up so high and then goes down. She is not able to eat anything. This has never happened to her before. His wife has never had diabetes and nobody in her family has any issues with that. Now, they are not able to go out to eat or do anything. Anytime she eats, her sugar goes up. The caller clarifies the dates of his wife's ER visits and hospitalizations: He clarifies the first time his wife went to the ER was 05Oct2021 or 06Oct2021. She was discharged at the ER after about 6 hours. The second time, she had the same symptoms. She had the fainting spell, sugar issues and she spent 2 days in the hospital. He clarifies the second visit was 08Oct2021 to 09Oct2021. She was admitted into the hospital and was there for 2 days. Caller clarifies his wife didn't go to the hospital for a third time. She just went to her doctor's after the second visit. He again states his wife has seen an Endocrinologist and GI doctors. His wife is still having test run and nobody can find out why she is hypoglycemic. Caller also adds ever since taking the COVID vaccine, his wife is foggy. She will be asked questions, and it's like his wife is not there. She has a hard time remembering things. The caller doesn't know why. This never happened before. Caller explains his wife takes thyroid medication, clarified as Synthroid, but she has been on this medicine for 5-6 years, maybe longer. She didn't have any problems with it. She was still going to gym, running her daily life while being on this medication. Now after getting the vaccines, they don't go anywhere. She can't eat out because she has sugar issues with anything she eats. She can't have a piece of bread, cereal or her blood sugar shoots up. Vaccination Facility Type was Pharmacy/Drug Store Vaccination. The first two doses were done through (withheld). He clarifies it was located at the (withheld) given by the Dept of Health. No Additional Vaccines Administered on Same Date of the Pfizer Suspect If applicable, list all vaccines administered on same date with the Pfizer vaccine considered as suspect. No Prior Vaccinations (within 4 weeks) to the first administration date of the suspect vaccine(s). None of the AE(s) following prior vaccinations. Caller explains the reason he is calling is because yesterday, he went online and had typed in adverse effects from Pfizer vaccine and he saw lots of blogs with different people (like 100 blogs) that were all pointing to the same thing: increased level of sugar. He read that some people weren't diabetic after the vaccine, but then had become diabetic. That is what he read with hundreds of different people on these blogs. Caller wants to know is there any issue with the vaccine where something like this can happen or affect the pancreas, liver that causes the person to produce more insulin.  Follow-up attempts are completed. No further information is expected.