BURST BLOOD VESSEL IN RIGHT EYE; HIGH BLOOD PRESSURE; RECURRENT EPISODES OF HOT FLASHES; TIREDNESS; NAUSEA; HEADACHE; This spontaneous report received from a patient concerned a 54 year old female. The patient's height, and weight were not reported. The patient's concurrent conditions included augmentin allergy, and levaquin allergy, and other pre-existing medical conditions included the patient had previous history of 2 medicated stents and history of widow maker in February 2020. in February 2021, all cardiology tests looked perfect and facial fillers 3 weeks before the vaccine. The patient received covid-19 vaccine ad26.cov2.s (suspension for injection, route of admin not reported and batch number: 041A21A expiry: UNKNOWN) dose was not reported, 1 total, administered on 07-APR-2021 to left arm for prophylactic vaccination. Concomitant medications included estrogens conjugated for hormone. On FEB-2021, Laboratory data included: Cardiovascular evaluation (NR: not provided) Normal. On APR-2021, the patient experienced headache. On 08-APR-2021, the patient experienced nausea and tiredness. The patient could not drink her coffee as usual and reported that she took dicyclomine HCL10mg four times a day started from 08-APR-2021 until 11-APR-2021. On 11-APR-2021, the patient experienced hot flashes, and it was beet red. The patient called obstetrician-gynecologist (OB GYN), as hot flashes were non-stop and were numerous in number of episodes and were waking her up at night and experienced high blood pressure. On 13-APR-2021, the patient experienced burst blood vessel in right eye in the evening. The patient experienced eye pain that felt like someone was sticking a knuckle in her eye socket which began around the time of the burst blood vessel. Patient checked blood pressure after noticing burst blood vessel and measured 230 to 240/ 125 to 140 mmHg (patient normally had blood pressure of 105/70mmHg). Patient went to the emergency room on 14-APR-2021 as per cardiologist, received clonidine, had electrocardiogram, bloodwork and chest x-ray done which were fine. The blood pressure was 190/115 at emergency room, patient had hot flash and blood pressure went up another 20 points. Patient turned red from belly to face during hot flashes. Patient was hospitalized on 14-APR-2021 and discharged on the same day.  Laboratory data included: Blood pressure (NR: not provided) 230-240/125-140 mmHg, 105/70 mmHg. Laboratory data included: Blood pressure (NR: not provided) 190/115, Blood test (NR: not provided) Fine, Chest X-ray (NR: not provided) Fine and electrocardiogram (EKG) (NR: not provided) Fine.  Additional treatment medications (dates unspecified) included: clonidine and dicycloverine hydrochloride. The action taken with covid-19 vaccine ad26.cov2.s was not applicable. The patient recovered from nausea on 11-APR-2021, was recovering from burst blood vessel in right eye, had not recovered from tiredness, recurrent episodes of hot flashes, and high blood pressure, and the outcome of headache was not reported. This report was serious (Other Medically Important Condition). This case, from the same reporter is linked to 20210438524, 20210437846 and 20210439405.; Sender's Comments: V0 20210438448-COVID-19 VACCINE AD26.COV2.S-Burst blood vessel in right eye, High blood pressure. This event(s) is considered not related. The event(s) has a compatible/suggestive temporal relationship, is unlabeled, and has unknown scientific plausibility. There are other factors more likely to be associated with the event(s) than the drug. Specifically: MEDICAL HISTORY