Vision issues but with no change in glasses prescription; Rash look like hives,specifically if sweat or get upset it accelerates; Skin on their cheeks is sloughing, skin has change; Seeing signs of depression; Seeing signs of anxiety.; Whole body itches; Hot flushes; Severe sweats; Whole body itches and its driving the crazy; feel like they are on fire; Toes hurt; Rash in their forearm,forehead,sculp,chest above their breast,below their collar bone; Extremely fatigued; Feel feverish; Headaches; This spontaneous case was reported by a consumer and describes the occurrence of VISUAL IMPAIRMENT (Vision issues but with no change in glasses prescription), URTICARIA (Rash look like hives,specifically if sweat or get upset it accelerates), SKIN EXFOLIATION (Skin on their cheeks is sloughing, skin has change), DEPRESSION (Seeing signs of depression) and ANXIETY (Seeing signs of anxiety.) in a 51-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 0151C21A and 050C21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     The patient's past medical history included Brain injury (is disabled) and Hysterectomy (Patient had hot flushes and severe sweats for 10 years due to menopause after Hysterectomy.). Concurrent medical conditions included Allergy NOS (is disabled). Concomitant products included DIAZEPAM for an unknown indication.   On 01-Jun-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 28-Jun-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. On an unknown date, the patient experienced VISUAL IMPAIRMENT (Vision issues but with no change in glasses prescription), URTICARIA (Rash look like hives,specifically if sweat or get upset it accelerates), SKIN EXFOLIATION (Skin on their cheeks is sloughing, skin has change), DEPRESSION (Seeing signs of depression), ANXIETY (Seeing signs of anxiety.), PRURITUS (Whole body itches), HOT FLUSH (Hot flushes), HYPERHIDROSIS (Severe sweats), FEELING ABNORMAL (Whole body itches and its driving the crazy), BURNING SENSATION (feel like they are on fire), PAIN IN EXTREMITY (Toes hurt), RASH (Rash in their forearm,forehead,sculp,chest above their breast,below their collar bone), FATIGUE (Extremely fatigued), PYREXIA (Feel feverish) and HEADACHE (Headaches). The patient was treated with DIPHENHYDRAMINE HYDROCHLORIDE (BENADRYL ALLERGY [DIPHENHYDRAMINE HYDROCHLORIDE]) for Adverse event, at a dose of 1 dosage form and COLECALCIFEROL (VITAMIN D [COLECALCIFEROL]) for Adverse event, at a dose of 1 dosage form. At the time of the report, VISUAL IMPAIRMENT (Vision issues but with no change in glasses prescription), URTICARIA (Rash look like hives,specifically if sweat or get upset it accelerates), SKIN EXFOLIATION (Skin on their cheeks is sloughing, skin has change), DEPRESSION (Seeing signs of depression), ANXIETY (Seeing signs of anxiety.), PRURITUS (Whole body itches), HOT FLUSH (Hot flushes), HYPERHIDROSIS (Severe sweats), FEELING ABNORMAL (Whole body itches and its driving the crazy), BURNING SENSATION (feel like they are on fire), PAIN IN EXTREMITY (Toes hurt), RASH (Rash in their forearm,forehead,sculp,chest above their breast,below their collar bone), FATIGUE (Extremely fatigued), PYREXIA (Feel feverish) and HEADACHE (Headaches) outcome was unknown.            Patient have a rare blood group, O negative, for that patient had taken some injection during pregnancies.  Patient had J&J bladder mesh for prolapse, to which her body reacts like it is a virus.  Patient was on other concomitant medications cholesterol medication 10 mg unspecified and sleeping pill at night.  Patient had hot flushes and severe sweating after vaccination which were not there anymore after 10 years of post-hysterectomy.  As treatment patient used natural cosmetic product with no dyes or perfumes, filter water for the shower, new bedding, pillows, mattress and special shampoos.