Recurrent Seizures; After second dose also lost his ability to think, walk and talk; After second dose also lost his ability to think, walk and talk; After second dose also lost his ability to think, walk and talk; Autoimmune Encephalitis; This is a spontaneous report from a contactable consumer (wife) reported for her husband and physician. A 51-years-old male patient received BNT162B2 (PFIZER-BIONTECH COVID-19 mRNA VACCINE, solution for injection, Lot Number: EW0187, expiry date: unknown), via an unspecified route, administered in left deltoid on 10Jun2021 (at the age of 51 years old) as dose 2, single for COVID-19 immunisation at hospital. Medical history included stroke in 2009, seizure, blood pressure (she did not think previous medication was relevant. It was blood pressure medication). No family medical history relevant to events, diabetes (he has steroid induced diabetes). There were no concomitant medications. Previously patient took BNT162B2 (PFIZER-BIONTECH COVID-19 mRNA VACCINE, solution for injection, Lot Number: ER8727), via an unspecified route, administered in left deltoid on 25Mar2021 as dose 1, single for COVID-19 immunisation and experienced lost his ability to think, walk and talk, seizure, autoimmune encephalitis, swelling of brain, tired. On an unspecified date of 2021, the patient experienced autoimmune encephalitis. On 10Sep2021 at 18:00, he experienced recurrent seizures. On 18Jun2021, slightly before 18:00, but late afternoon, after second dose also lost his ability to think, walk and talk. The patient was hospitalized for recurrent seizures from 10Sep2021 to 16Sep2021, for after second dose also lost his ability to think, walk and talk from 18Jun2021 to 06Aug2021. The patient underwent lab tests and procedures which included blood immunoglobulin g resulted positive on unknown date, blood test with unknown results (Blood work 2 weeks ago he checked blood work, his numbers were high, and they had to come down). All the events resulted in emergency room and physician office visit. Therapeutic measures were taken as a result of autoimmune encephalitis, recurrent seizures, after second dose also lost his ability to think, walk and talk. Reporter stated that patient was still getting Physical Therapy. He was still having trouble with speech. He gets speech therapy with everyone helping, he was getting better. He has to get on a regimen where he gets an infusion every 6 months and that was what will keep him alive. The infusion was Rituximab, and he was due for next treatment 01Nov2021. Reporter knows it was Prednisone, but not sure the other ones they were giving to treat him. He was still on Prednisone now. They ran every test possible and were all inconclusive and was negative. When he got out the first time, he saw his primary care and then he had an autoimmune visit with who was autoimmune neurologist. He was giving the Rituximab infusion every 6 months. He was hospitalized from Apr2021 to Aug 2021 and had a short period of time that he had to go back to the hospital because of seizures again. They are not sure why he was still having seizures since he was on the medication, Depakote and Keppra. The doses have been changed. First, he was taking 500mg Depakote twice daily and thinks when he checked blood work, his numbers were high, and they had to come down. Then she corrected and said he was still on that. It was the Keppra that was changed. Keppra was 1500 mg twice daily, but when they did blood work 2 weeks ago, his numbers were high, and they cut him to 1,000 mg twice daily. It was in a pharmacy vial with no lot or expiration. The clinical outcome of the event autoimmune encephalitis was recovered with sequelae on an unspecified date in 2021, after second dose also lost his ability to think, walk and talk was recovering, and recurrent seizures was recovered in Sep2021.  No follow-up attempts are possible. No further information is expected.