Hyper dynamic left ventricle/Ejection fraction rate was in the 90s, both resting and during exercise/They said I have a hyperdynamic heart/it showed a hyper dynamic left ventricle/had a hyperdynamic heart; This spontaneous case was reported by a patient and describes the occurrence of HYPERDYNAMIC LEFT VENTRICLE (Hyper dynamic left ventricle/Ejection fraction rate was in the 90s, both resting and during exercise/They said I have a hyperdynamic heart/it showed a hyper dynamic left ventricle/had a hyperdynamic heart) in a 66-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 056M21A, 033F21A, 010A21A and 039K20A) for COVID-19 prophylaxis.     Concurrent medical conditions included Heart disorder and Coronary artery disease.   On 05-Feb-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 05-Mar-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 01-Nov-2021, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 12-May-2022, received fourth dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 29-Sep-2022,  after starting mRNA-1273 (Moderna COVID-19 Vaccine), the patient experienced HYPERDYNAMIC LEFT VENTRICLE (Hyper dynamic left ventricle/Ejection fraction rate was in the 90s, both resting and during exercise/They said I have a hyperdynamic heart/it showed a hyper dynamic left ventricle/had a hyperdynamic heart) (seriousness criterion medically significant). At the time of the report, HYPERDYNAMIC LEFT VENTRICLE (Hyper dynamic left ventricle/Ejection fraction rate was in the 90s, both resting and during exercise/They said I have a hyperdynamic heart/it showed a hyper dynamic left ventricle/had a hyperdynamic heart) outcome was unknown.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): In 2018, Cardiac stress test: Normal. On 29-Sep-2022, Cardiac stress test: hyper dynamic left ventricle. On 29-Sep-2022, Ejection fraction: was in the 90s, both resting and during exercise.         No concomitant product was reported. Patient had been on the same medications for many years. She was worried about her condition and did not wanted anything to be abnormal. She had some heart palpitations and shortness of breath. No treatment information was reported. She would be visiting cardiologist next week to have an echocardiogram.  Company Comment: This is a Spontaneous case concerning a 66-year-old female patient with concurrent medical conditions of Heart disorder and Coronary artery disease, who experienced the serious unexpected event of Hyperdynamic left ventricle which occurred approximately 4 months a after the fourth dose of mRNA-1273 for COVID-19 Vaccination. The medical history of Heart disorder and Coronary artery disease remain as confounders. Diagnosis was performed after performing cardiac stress test. It was also reported that ejection fraction was in the 90s, both resting and during exercise. No concomitant medication or treatment information was reported. A visit to cardiologist and echocardiogram was scheduled. The benefit-risk relationship of COVID-19 Vaccine Moderna (mRNA-1273) is not affected by this report.; Sender's Comments: This is a Spontaneous case concerning a 66-year-old female patient with concurrent medical conditions of Heart disorder and Coronary artery disease, who experienced the serious unexpected event of Hyperdynamic left ventricle which occurred approximately 4 months a after the fourth dose of mRNA-1273 for COVID-19 Vaccination. The medical history of Heart disorder and Coronary artery disease remain as confounders. Diagnosis was performed after performing cardiac stress test. It was also reported that ejection fraction was in the 90s, both resting and during exercise. No concomitant medication or treatment information was reported. A visit to cardiologist and echocardiogram was scheduled. The benefit-risk relationship of COVID-19 Vaccine Moderna (mRNA-1273) is not affected by this report.