extreme swelling in her feet; her right foot turned black; burning in her hands and feet and joints; burning in her hands and feet and joints; had respiratory issues; mild asthma; Anxiety; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP) from medical information team. The reporter is the patient.  A 53 year-old female patient received bnt162b2 (BNT162B2), administered in arm left, administration date 02Mar2021 (Lot number: EN6200, Expiration Date: Jun2021) at the age of 53 years as dose 1, single for covid-19 immunisation. Relevant medical history included: "Splenectomy", start date: Jun2000 (unspecified if ongoing); "mild asthma", start date: 2012 (ongoing); "Guillain Barre syndrome" (unspecified if ongoing), notes: diagnosed about 30 years ago; "Pituitary adenoma", start date: 1995 (unspecified if ongoing); "sjogrens" (unspecified if ongoing), notes: a positive ANA for Sjogren's around 1995-1998; "ITP" (unspecified if ongoing). The patient's concomitant medications were not reported. Vaccination history included: Swine flu vaccine (about 30 years ago), for Immunization; Pneumococcal vaccine (Four pneumococcal vaccine about 30 years ago), for Immunization. The following information was reported: PERIPHERAL SWELLING (non-serious) with onset Mar2021, outcome "not recovered", described as "extreme swelling in her feet"; SKIN DISORDER (non-serious) with onset Mar2021, outcome "not recovered", described as "her right foot turned black"; BURNING SENSATION (non-serious), ARTHRALGIA (non-serious) all with onset Mar2021, outcome "not recovered" and all described as "burning in her hands and feet and joints"; RESPIRATORY DISORDER (non-serious) with onset 2021, outcome "unknown", described as "had respiratory issues"; ASTHMA (non-serious) with onset 2021, outcome "unknown", described as "mild asthma"; ANXIETY (non-serious) with onset 2021, outcome "unknown", described as "Anxiety". Relevant laboratory tests and procedures are available in the appropriate section. No follow-up attempts are possible. No further information is expected. This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP) from medical information team. The reporter is the patient.  A 53 year-old female patient received bnt162b2 (BNT162B2), administered in arm left, administration date 02Mar2021 (Lot number: EN6200, Expiration Date: Jun2021) at the age of 53 years as dose 1, single for covid-19 immunisation. Relevant medical history included: "Splenectomy", start date: Jun2000 (unspecified if ongoing); "mild asthma", start date: 2012 (ongoing); "Guillain Barre syndrome" (unspecified if ongoing), notes: diagnosed about 30 years ago; "Pituitary adenoma", start date: 1995 (unspecified if ongoing); "sjogrens" (unspecified if ongoing), notes: a positive ANA for Sjogren's around 1995-1998; "ITP" (unspecified if ongoing). The patient's concomitant medications were not reported. Vaccination history included: Swine flu vaccine (about 30 years ago), for Immunization; Pneumococcal vaccine (Four pneumococcal vaccine about 30 years ago), for Immunization. The following information was reported: PERIPHERAL SWELLING (non-serious) with onset Mar2021, outcome "not recovered", described as "extreme swelling in her feet"; SKIN DISORDER (non-serious) with onset Mar2021, outcome "not recovered", described as "her right foot turned black"; BURNING SENSATION (non-serious), ARTHRALGIA (non-serious) all with onset Mar2021, outcome "not recovered" and all described as "burning in her hands and feet and joints"; RESPIRATORY DISORDER (non-serious) with onset 2021, outcome "unknown", described as "had respiratory issues"; ASTHMA (non-serious) with onset 2021, outcome "unknown", described as "mild asthma"; ANXIETY (non-serious) with onset 2021, outcome "unknown", described as "Anxiety". Relevant laboratory tests and procedures are available in the appropriate section.  Clinical course: States the symptoms after the 1st dose of the Pfizer COVID Vaccine began maybe 6 hours after the vaccine and she was at work when this started popping off and it was not until she got home that it was substantially worse; states she had extreme swelling in her feet, her right foot turned black, she had burning in her hands and feet and joints; states she has always had a reaction like that to every single vaccine she had post splenectomy. States that for any other vaccine she has had a reaction to she has no names, lots, expiry dates or NDC numbers to provide but they were four pneumococcal vaccine and she had the flu vaccine probably 30 years ago with severe reaction and confirmation of Guillian Barre so she does not take the flu vaccine; states her concern was Guillian Barre type reactions with the Pfizer Covid vaccine but she was told the makeup of the flu vaccine is different than the Pfizer Covid vaccine and asks if this is true. Caller states for the 1st dose of the Pfizer COVID Vaccine she also had respiratory issues and thinking it was anxiety more so and has mild asthma that may have triggered some asthmatic but it was all anxiety related. Patient did not visit Emergency Room or physician Office due to events. Family medical history was reported as None. Patient states she had the 2nd dose on 23Mar2021 and Pfizer COVID booster shot on 17Aug2021.  No follow-up attempts are possible. No further information is expected.