Very angry; Severe eczema which started on the top of her hands; Fatigue; Depression; Not being able to get things done due to shortness of breath; Not being able to get things done due to shortness of breath; Head to toe itching inside her body, including on her scalp; Stiffness and soreness from hips on down; Stiffness and soreness from hips on down; This is a spontaneous report received from a non-contactable reporter(s) (Consumer or other non HCP) from medical information team. The reporter is the patient.  A 69-year-old female patient received BNT162b2 (BNT162B2), on 07Jan2022 as dose 3 (booster), single (Batch/Lot number: unknown) at the age of 69 years for covid-19 immunisation. The patient's relevant medical history and concomitant medications were not reported. Vaccination history included: Bnt162b2 (Dose number: 1), for COVID-19 immunization, reaction(s): "no side effects"; Bnt162b2 (Dose number: 2), for COVID-19 immunization, reaction(s): "she experienced stiffness in her joints and muscles from her hips on down", "she experienced stiffness in her joints and muscles from her hips on down"; Flu shot, for immunization, reaction(s): "no side effects". The following information was reported: DEPRESSION (non-serious) with onset 2022, outcome "unknown"; FATIGUE (non-serious) with onset 2022, outcome "unknown"; PRURITUS (non-serious) with onset 2022, outcome "not recovered", described as "Head to toe itching inside her body, including on her scalp"; DYSPNOEA (non-serious), LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (non-serious) all with onset 2022, outcome "unknown" and all described as "Not being able to get things done due to shortness of breath"; HAND DERMATITIS (non-serious) with onset 2022, outcome "recovered" (2022), described as "Severe eczema which started on the top of her hands"; MUSCULOSKELETAL STIFFNESS (non-serious), PAIN (non-serious) all with onset 2022, outcome "unknown" and all described as "Stiffness and soreness from hips on down"; ANGER (non-serious) with onset 2022, outcome "unknown", described as "Very angry". The event "severe eczema which started on the top of her hands" required physician office visit. The event "head to toe itching inside her body, including on her scalp" required emergency room visit. Therapeutic measures were taken as a result of hand dermatitis. Additional information: Patient received her 1st Pfizer COVID-19 booster vaccine on 07Jan2022. Stated that she was very angry and had went through hell since she got the booster vaccine. Caller stated that she had already called Pfizer Medical Information twice including on Saturday. Caller stated that since receiving the booster vaccine, she had severe eczema which started on the top of her hands. Caller stated she saw a dermatologist who prescribed her for an expensive cream which helped the eczema on her hands get better. Caller stated that she was also experienced fatigue. depression, and not being able to get things done due to shortness of breath. Caller stated that she now had head to toe itching inside her body, including on her scalp, but there was no rash or pus/crustiness like she had previously with the eczema on her hands. Caller stated that she tried not to itch it and it calms down and then goes to other locations. Caller stated she called the ER on Saturday because the itching was so bad, but they had no recommendations for her. Caller stated that she had the 1st Pfizer COVID-19 vaccine, and a flu shot and had no side effects from either, but after the 2nd Pfizer COVID-19 vaccine, she experienced stiffness in her joints and muscles from her hips on down which lasted for 4 months and then resolved. Caller stated that after she received the Pfizer COVID-19 booster she also experienced stiffness and soreness from hips on down. Caller asked would this booster vaccine wane or wear off?  No follow-up attempts are possible; information about lot/batch number cannot be obtained. No further information is expected.