Face turned bright red and purple; Face turned bright red and purple; caller's skin turned leather, hard like a piece of leather; it peeled off, copious peeling, lots of peeling, it was charming; This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP). The reporter is the patient.  A 71 year-old female patient received bnt162b2 (BNT162B2), administered in arm left, administration date 07Apr2021 11:00 (Lot number: ER8733) at the age of 71 years as dose 2, single for covid-19 immunisation. Relevant medical history included: "Mast cell activation syndrome" (ongoing); "Several autoimmune situations" (ongoing). The patient's concomitant medications were not reported. Vaccination history included: Bnt162b2 (Dose Number:01, Batch/lot number :EN6204 , Route of administration: Left arm, NDC: Unknown , Expiration: Unknown, Time of vaccination: First dose: 0800), administration date: 10Mar2021, when the patient was 70 years old, for Covid-19 Immunization, reaction(s): "Felt a little bit fluey"; Flu vaccine (Dose number unknown), for immunization, reaction(s): "little bit fluey"; Rabies (booster, rabies booster was a good 20 years ago.), for immunization, reaction(s): "little bit fluey". The following information was reported: ERYTHEMA (non-serious), SKIN DISCOLOURATION (non-serious) all with onset 09Apr2021, outcome "recovered" (2021) and all described as "Face turned bright red and purple"; MUSCULOSKELETAL STIFFNESS (non-serious) with onset 09Apr2021, outcome "recovered" (2021), described as "caller's skin turned leather, hard like a piece of leather"; SKIN EXFOLIATION (non-serious) with onset Apr2021, outcome "recovered" (2021), described as "it peeled off, copious peeling, lots of peeling, it was charming". The events "face turned bright red and purple", "face turned bright red and purple", "caller's skin turned leather, hard like a piece of leather" and "it peeled off, copious peeling, lots of peeling, it was charming" were evaluated at the physician office visit. Relevant laboratory tests and procedures are available in the appropriate section.  Additional Information: Patient has tissue autoimmune to thyroid, bone, liver and has one other going on, nerve to sheath, hasn't put a name on it, its autoimmune. The patient states the tissue autoimmune to thyroid, bone, liver, and nerve to sheath have just been specified within the last two months, but the patient states this has been going on since before any dose of the Adult Pfizer Vaccine. The patient has had for many years. The patient face turned bright red and purple. The red and purple did not extend down into neck very much. Then the patient skin turned leather, hard like a piece of leather. Then over one weeks' time, it peeled off, copious peeling, lots of peeling, it was charming. The patient has had this reaction before receiving the Adult Pfizer Vaccine but does not know what precipitates the reaction. The patient looks a lot younger now that a month of peeling on the face. Why go get last treatments. The patient states the peeling probably was over in 10 days after receiving the second dose Adult Pfizer Vaccine.  No follow-up attempts are possible. No further information is expected.