HEAVY VAGINAL BLEEDING (FEW DAYS AFTER HAVING FINISHED PERIOD); PERIOD 3 WEEKS EARLY; PAIN AT INJECTION SITE; TINGLING IN ARMS AND LEGS; HEADACHE/TENDERNESS ON TOP OF HEAD; INCREASED HAIR LOSS; LETHARGY (SLEPT 15 HOURS A DAY FOR 3 DAYS); DIFFICULTY BREATHING/ SHORTNESS OF BREATH; CHEST TIGHTNESS; This spontaneous report received from a patient concerned a 40 year old female. The patient's weight was 118 pounds and height was not reported.  The patient's concurrent conditions included: autistic spectrum (processing disorder), abstained from alcohol, non smoker, ADHD (Attention deficit hyperactivity disorder), severe anxiety disorder, Ehlers Danlos (connective tissue disorder), complex post-traumatic stress disorder, contrast dye allergy, allergy to antidepressant and allergy medication, and vaccine reaction when she was a child, and other pre-existing medical conditions included: The patient had no history of drug abuse or illicit drug use. The patient was planning to have genetic test for allergies and how medications react. The patient previously received covid-19 vaccine ad26.cov2.s (dose number in Series 1) (suspension for injection, route of admin not reported and batch number: 205A21A) dose was not reported, 1 total, administered on 12-APR-2021 for prophylactic vaccination. The patient had bad reaction such as chest tightness, difficulty breathing/ shortness of breath, hair falling out, headache/tenderness on top of head, pain at injection site hurt for about week and a half, period stopped for 4 months, sick for a week and involuntary weight loss following vaccination with first dose of covid-19 vaccine ad26. cov2. s (dose number in Series 1). The patient's period had stopped on 09-DEC-2021.  The patient recovered from chest tightness, shortness of breath/difficulty breathing, sick for a week, headache/tenderness on top of head, and pain at injection site hurt for about a week a half, and had not recovered from hair falling out, and involuntary weight loss following vaccination. The outcome of period stopped for 4 months was unknown. The patient received covid-19 vaccine ad26.cov2.s (dose number in Series 2) (suspension for injection, route of admin not reported, batch number: 1855191, expiry: UNKNOWN) dose was not reported, 1 total, administered on right arm on 10-DEC-2021 for prophylactic vaccination. Concomitant medications included Xanax (alprazolam), marihuana (cannabis sativa) and ketamine for complex post-traumatic stress disorder.  On 10-DEC-2021, following vaccination with covid-19 vaccine ad26.cov2.s (dose number in Series 2), the patient had pain at injection site. On 12-DEC-2021, patient had period 3 weeks early and heavy vaginal bleeding (few days after having finished period). She stated that she used one super tampon for 2 hours maximum. On an unspecified date in DEC-2021, the patient had same symptoms as with first vaccine. She had increased hair loss, lethargy (slept 15 hours a day for 3 days), difficulty breathing/ shortness of breath, chest tightness, headache/ tenderness on top of head, experienced tingling in arms and legs. As on report time, patient had just tenderness and excessive bleeding (dose number in Series 2). The JNJ booster doubled hair loss and "period 3 weeks early". The patient visited emergency room for the treatment of the events. It was reported that, the patient talked to her old doctor about symptoms who had heard a lot about JNJ and these effects and recommended patient to get a full hormone panel and patient was planning to do as she could not found an appointment with doctor of medicine (MD) before February The action taken with covid-19 vaccine ad26.cov2.s was not applicable. The patient recovered from increased hair loss, lethargy (slept 15 hours a day for 3 days), difficulty breathing/ shortness of breath, chest tightness, and tingling in arms and legs on DEC-2021, and pain at injection site on 15-DEC-2021, had not recovered from headache/tenderness on top of head, and heavy vaginal bleeding (few days after having finished period), and the outcome of period 3 weeks early was not reported. This report was non-serious. This case, involving the same patient is linked to 20211235199.