her throat started to feel like it's really tight and closing but it didn't actually close/Throat tightness; Woozy; Fatigue; she feels like it's getting worse/this morning it is progressively getting tighter; This is a spontaneous report from a contactable consumer (patient). A 55-year-old female patient received first dose of bnt162b2 (PFIZER-BIONTECH COVID-19 mRNA VACCINE, Formulation: Solution for injection, Lot number: EL9261), via an unspecified route of administration in right arm on 04Feb2021 at 09:17 am as a single dose for COVID-19 immunization. The patient's medical history included cancer was diagnosed in Jun2019. The Enlarged Goiter Onset was about 10 years ago, her mom actually had thyroid cancer and so because of that she had her throat checked, they told her in the past that it was large and to not worry, but then she also got body whole scan in Dec2020, the oncologist said she has an enlarged goiter and that she has nothing to worry about. Concomitant medication included anastrozole (ARIMIDEX). She has had no positive covid or antibody test prior to the first dose. She has had no other vaccinations in the 4 weeks prior. She has had no issues with vaccines in the past, no allergies nothing. On the night of 04Feb2021, the patient stated that at night her throat felt like it was really tight and closing but it didn't actually close. She was still experiencing it at the moment and felt like it was getting worse. She concerned and stated that, she did get the first dose yesterday and she felt woozy, she felt fatigue. She noticed as she was going to bed, her throat was tight, all night long she was adjusting her pillow, it just feels tight, and this morning it was progressively getting tighter. She does want to add a bit of background that she thinks could be related, that she was a cancer survivor, but it's not even a year out that she has been cancer free, she still takes Arimidex. They also did a scan and said that she had an enlarged goiter, so she has had the throat problems for the last month or so. Caller states that she did not know if this was associated. The patient stated that she felt woozy right after receiving the vaccine, within first 15 minutes. The Fatigue was also on the same day around 4PM or 3:30PM. It was like a suppression feeling. She was talking to herself calm down, she was just feeling overwhelmed, she had to tell herself to relax, and drank water. The patient also experienced Fatigue which ended after she took a nap. Caller clarified that she thinks that she has experience throat tightening before, when she was either sick or had a sore throat, but at the moment when she was experiencing throat tightening recently, she would just try to say herself to calm down. The patient stated that the throat tightening started at night, when she was about to relax before bed on 04Feb2021. The patient stated that as she was going to bed, her throat was tight, all night long and she was adjusting her pillow, it just felt tight, and in the morning, it was progressively getting tighter. She was drinking hot and warm tea but even that's making it worse. The caller stated that she actually has 3 doctors whom she frequently visits. and she was still monitoring her because the cancer she had was aggressive. There was also her Primary Care doctor. Wants to know what she needs to do about it and if this is because of the vaccine. Caller wanted to know about risks of the vaccine what to do with the side effects and who should not get the vaccine. Therapeutic measures were taken as a result of her throat started to feel like it's really tight and closing but it didn't actually close/throat tightness, woozy, and fatigue. The outcome of the events was resolved for woozy, and fatigue on 04Feb2021, and not resolved for the evenst throat tightening and feels like it's getting worse/this morning it is progressively getting tighter.   Follow-up attempts completed. No further information expected.