thought i was dying; Suspected vaccination failure/Suspected vaccination failure; shingles outbreak in Nov or Dec 2021, on 20Apr2022; pain; flare up, sacroiliitis; deadly ill; Bedridden for 2 months; This case was reported by a consumer via research programs and described the occurrence of impending doom in a 50-year-old female patient who received Herpes zoster (Shingrix) for prophylaxis.   Co-suspect products included Herpes zoster (Shingrix) for prophylaxis.   The patient's past medical history included shingles (had chronic shingles for last 24 years). Concurrent medical conditions included palindromic rheumatoid arthritis (had as a child), ehlers-danlos syndrome, chiari malformation, irritable bowel syndrome, cystitis interstitial, thyroid nodule, pituitary adenoma (was monitor with MRI's), dyspepsia, optic nerve hypoplasia (found in 2019 by a neuro narrowing of the congenital optic nerve), exertional dyspnea, syncope, degeneration of lumbar or lumbosacral intervertebral disc, sacroiliitis (was part of the ED), retinal dystrophy (defective functioning of retinal pigment epithelial cells and both rod and cone photoreceptors), retinitis pigmentosa (genetic), nuclear sclerosis of the eye, precancerous condition, hysterectomy, endometriosis, baker's cyst (behind the left knee), enlargement of lymph nodes, psychotic symptom (high ASO tighter) and multiple allergies.   In July 2020, the patient received the 2nd dose of Shingrix. In February 2020, the patient received the 1st dose of Shingrix. In February 2020, not applicable after receiving Shingrix and less than a month after receiving Shingrix, the patient experienced illness (serious criteria hospitalization) and bedridden (serious criteria hospitalization). On an unknown date, the patient experienced impending doom (serious criteria hospitalization), vaccination failure (serious criteria hospitalization and GSK medically significant), shingles (serious criteria hospitalization), pain (serious criteria hospitalization) and sacroiliitis (serious criteria hospitalization). The patient was treated with valaciclovir (Valacyclovir). On an unknown date, the outcome of the impending doom, vaccination failure and illness were unknown and the outcome of the shingles, pain and sacroiliitis were not recovered/not resolved and the outcome of the bedridden was recovered/resolved.   It was unknown if the reporter considered the vaccination failure, shingles, pain and sacroiliitis to be related to Shingrix. It was unknown if the reporter considered the impending doom, vaccination failure, shingles, pain, illness and bedridden to be related to Shingrix.     Additional Information: GSK Receipt Date: 22-APR-2022 Reporter's Comment: The case was received from the patient via research program. The current condition included (the patient did not provide name of condition for acronym). Less than a month after 1st dose, the dose made her deadly ill and was bedridden for 2 months.  The patient thought she was dying. The patient had next dose might be next five or six months later (estimated in July 2020). The patient did not note that she was hospitalized. The patient reported that, at the time of reporting, between 1 and 2 years after vaccinations, since had the Shingrix vaccine she had an outbreak in November or December 2021 and did not had much pain with the one. This current shingles outbreak was much more painful. The patient picked up prescription of Valacyclovir yesterday. On 20th April 2022, the patient broke out with shingles the night Wednesday. Less than 2 years after 2nd dose, the patient was thinking she was having a flare up of sacroiliitis since the pain was so bad. The only place she got shingles was on the area of buttocks about the size of a 50-cent piece. The patient had shingles 1 to 2 times per year since she had shingles vaccination but prior to that she would get it 1 to 4 times per year. Did not consent to follow-up. Additional Supportive Information: This case was considered as suspected vaccination failure as details regarding laboratory test confirming shingles were unknown at the time of reporting. Note: Hospitalization was marked for all events as it was not clearly for which event patient was hospitalized.