Pretty serious asthma exacerbation; All the respiratory symptoms like she had COVID all over again; Significant change in daily activities; This spontaneous case was reported by a nurse and describes the occurrence of ASTHMA (Pretty serious asthma exacerbation), RESPIRATORY SYMPTOM (All the respiratory symptoms like she had COVID all over again) and LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (Significant change in daily activities) in a 41-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch no. 037C21A) for COVID-19 vaccination.     The patient's past medical history included COVID-19 in January 2021. Concurrent medical conditions included Asthma.    On 13-Aug-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 14-Aug-2021, the patient experienced ASTHMA (Pretty serious asthma exacerbation) (seriousness criterion hospitalization). In August 2021, the patient experienced RESPIRATORY SYMPTOM (All the respiratory symptoms like she had COVID all over again) (seriousness criterion hospitalization) and LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (Significant change in daily activities) (seriousness criterion disability). At the time of the report, ASTHMA (Pretty serious asthma exacerbation), RESPIRATORY SYMPTOM (All the respiratory symptoms like she had COVID all over again) and LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (Significant change in daily activities) was resolving.        The action taken with mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown) was unknown.   For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown), the reporter did not provide any causality assessments.   Concomitant medications were not reported.  Treatment information was not provided by the reporter.  Patient reported that after receiving the vaccine she was hospitalized overnight ,but it was not an anaphylactic reaction mean while it cause changes in her daily activities. Patient started feeling better in the last one to two weeks and now she was just able to clean her house.  Company's comment: This case concerns a 41-year-old female patient with previous relevant medical history of asthma, who experienced the unexpected events of Asthma, Respiratory Symptoms and Loss of Personal Independence in Daily Activities. Rechallenge is unknown since no information about the second dose was disclosed. The events occurred approximately 1 day after the first dose of mRNA-1273 (Moderna COVID-19 Vaccine) with outcome of hospitalization. The medical history of asthma remains a confounder. The benefit-risk relationship of mRNA-1273 (Moderna COVID-19 Vaccine) is not affected by this report.; Sender's Comments: This case concerns a 41-year-old female patient with previous relevant medical history of asthma, who experienced the unexpected events of Asthma, Respiratory Symptoms and Loss of Personal Independence in Daily Activities. Rechallenge is unknown since no information about the second dose was disclosed. The events occurred approximately 1 day after the first dose of mRNA-1273 (Moderna COVID-19 Vaccine) with outcome of hospitalization. The medical history of asthma remains a confounder. The benefit-risk relationship of mRNA-1273 (Moderna COVID-19 Vaccine) is not affected by this report.