axillary pain and tenderness; submandibular lymph swelling, occipital lymph node swelling; painful arm; hot arm; target shape rash; soreness at injection site; itching arm/ arm was pruritic; red arm; swollen arm/ swollen to the size of a baseball; lethargy; This spontaneous case was reported by a nurse (subsequently medically confirmed) and describes the occurrence of PRURITUS (itching arm/ arm was pruritic), ERYTHEMA (red arm), PERIPHERAL SWELLING (swollen arm/ swollen to the size of a baseball), LETHARGY (lethargy) and PAIN IN EXTREMITY (painful arm) in a 28-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch no. 007M20A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     No Medical history was reported.     On 18-Feb-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 18-Feb-2021, the patient experienced PRURITUS (itching arm/ arm was pruritic), ERYTHEMA (red arm), PERIPHERAL SWELLING (swollen arm/ swollen to the size of a baseball), LETHARGY (lethargy) and VACCINATION SITE PAIN (soreness at injection site). On 25-Feb-2021, the patient experienced PAIN IN EXTREMITY (painful arm), FEELING HOT (hot arm) and RASH (target shape rash). On 09-Mar-2021, the patient experienced AXILLARY PAIN (axillary pain and tenderness) and LYMPHADENOPATHY (submandibular lymph swelling, occipital lymph node swelling). The patient was treated with NAPROXEN at an unspecified dose and frequency. On 09-Mar-2021, PRURITUS (itching arm/ arm was pruritic), ERYTHEMA (red arm), PERIPHERAL SWELLING (swollen arm/ swollen to the size of a baseball), PAIN IN EXTREMITY (painful arm), FEELING HOT (hot arm), RASH (target shape rash) and VACCINATION SITE PAIN (soreness at injection site) had resolved. At the time of the report, LETHARGY (lethargy) had resolved and AXILLARY PAIN (axillary pain and tenderness) and LYMPHADENOPATHY (submandibular lymph swelling, occipital lymph node swelling) outcome was unknown. Not Provided    DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On an unknown date, Blood test: normal normal.     The action taken with mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) was unknown.   For mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular), the reporter did not provide any causality assessments.   No concomitant medications were reported. Treatment medications included naproxen and antihistamines.  Patient reports a mild initial reaction including, soreness at the injection site, itching, redness, swelling, and lethargy starting on 18Feb2021 and lasting a few days. Patient reports a week later 25-Feb-2021 her arm became painful and swollen to the size of a baseball. Patient reports her arm was also pruritic and hot. Patient reports lethargy lasting approximately one day. Patient self administered naproxen to treat her symptoms. Patient reports swelling, pain, and itching lasted roughly one week. Patient reports rash eventually diminished to a target shape approximately 3cm around, and has since cleared up. Patient reports resolution of symptoms for a short period until 9Mar2021. Patient reports awakening on 9Mar2021 lethargic, with axillary pain and tenderness, occipital lymph node swelling, and submandibular lymph swelling. Patient visited an Urgent Care Center and was sent for blood work. Patient later sought additional care at the ER. Patient reports blood work was found to be normal. Patient is currently taking antihistamines to relieve symptoms.