severe Charlie Horse cramps in calve muscles; flu like symptoms (fever, chills, body aches); flu like symptoms (fever, chills, body aches); flu like symptoms (fever, chills, body aches); flu like symptoms (fever, chills, body aches); muscle ache; twitching, pins and needles in calves (both legs); twitching, pins and needles in calves (both legs); calves felt like bricks, very stiff; This is a spontaneous report received from a contactable other healthcare professional. The reporter is the patient.  A 40-year-old female patient (not pregnant) received BNT162B2 (COMIRNATY, Solution for injection), administered in the left arm, administration date 19Dec2021 05:00 (Lot number: FJ8757) at the age of 40 years as dose 2, single for COVID-19 immunisation. Relevant medical history included: "Asthma" (unspecified if ongoing); "Eczema" (unspecified if ongoing). There were no concomitant medications. Vaccination history included: BNT162B2 (dose 1, administered in the left arm, Batch/Lot number: FJ1620), administration date: 28Nov2021 05:00, when the patient was 40 years old, for COVID-19 immunisation, reactions: "resulting in waking up every night in the middle of the night with uncomfortable feeling in legs, pins and needles", "restless leg type symptoms at night". The following information was reported: MUSCLE SPASMS (non-serious) with onset 19Dec2021 17:00, outcome "recovered with sequelae" (2021), described as "severe Charlie Horse cramps in calve muscles"; INFLUENZA LIKE ILLNESS (non-serious), PYREXIA (non-serious), CHILLS (non-serious), PAIN (non-serious) all with onset 19Dec2021 17:00, outcome "recovered with sequelae" (2021) and all described as "flu like symptoms (fever, chills, body aches)"; MYALGIA (non-serious) with onset 19Dec2021 17:00, outcome "recovered with sequelae" (2021), described as "muscle ache"; MUSCLE TWITCHING (non-serious), PARAESTHESIA (non-serious) all with onset 19Dec2021 17:00, outcome "recovered with sequelae" (2021) and all described as "twitching, pins and needles in calves (both legs)"; MUSCULOSKELETAL STIFFNESS (non-serious) with onset 19Dec2021 17:00, outcome "recovered with sequelae" (2021), described as "calves felt like bricks, very stiff". The events "severe charlie horse cramps in calve muscles", "flu like symptoms (fever, chills, body aches)", "muscle ache", "twitching, pins and needles in calves (both legs)" and "calves felt like bricks, very stiff" were evaluated at the physician office visit. Therapeutic measures were not taken as a result of muscle spasms, influenza like illness, pyrexia, chills, pain, myalgia, muscle twitching, paraesthesia, musculoskeletal stiffness.  Additional information: The patient has no known allergies. She had no other vaccines within four weeks of vaccination and other medications in two weeks. The patient was not diagnosed with COVID-19 prior to vaccination, and she has not been tested for COVID-19 since the vaccination. Twelve hours after the second dose, the patient experienced severe Charlie Horse cramps in calve muscles along with flu like symptoms (fever, chills, body aches). Worst of the muscle cramping ended by the next morning, however every night since then she was walking up in the middle of the night with muscle aches, twitching, pins and needles in calves (both legs). In the morning, calves felt like bricks, very stiff, throughout the day experienced pins and needles in legs. The patient recovered from the events with lasting effects.   Follow-up attempts are completed. No further information is expected.