Unsure whether she is experiencing GBS; Worsening of CIDP; Balance gotten worse; Worsening of CIDP; Balance gotten worse; Did not feel her left arm, no sensation; Felt tingling; Accidentally stabbed left hand. Noticed when started bleeding; Harder to walk; balance gotten worse/Imbalance; This case was reported by a consumer via call center representative and described the occurrence of guillain barre syndrome in a female patient who received Herpes zoster (Shingrix) for prophylaxis.   Concurrent medical conditions included chronic inflammatory demyelinating polyneuropathy.   On 8th November 2021, the patient received the 1st dose of Shingrix (intramuscular). In November 2021, less than a week after receiving Shingrix, the patient experienced guillain barre syndrome (serious criteria GSK medically significant), chronic inflammatory demyelinating polyradiculoneuropathy (serious criteria GSK medically significant), condition aggravated, numbness of upper extremities, tingling, hand injury, walking difficulty and balance disorder. On an unknown date, the outcome of the guillain barre syndrome was unknown and the outcome of the chronic inflammatory demyelinating polyradiculoneuropathy, condition aggravated, numbness of upper extremities, tingling, hand injury, walking difficulty and balance disorder were not recovered/not resolved.   It was unknown if the reporter considered the guillain barre syndrome, chronic inflammatory demyelinating polyradiculoneuropathy, condition aggravated, numbness of upper extremities, tingling, hand injury, walking difficulty and balance disorder to be related to Shingrix.  Additional case details were provided as follows: The case was reported by the patient. The age at vaccination was not reported. The patient received 1st dose of Shingrix on 8 November 2021 in the afternoon on left arm.  She stated that at the night of that day she fell as sleep on sofa, and around 4:00am on 9th November 2021 she did not feel her left arm (numbness).  The patient had no sensation, but she felt tingling.  She stated that chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) was a neurological disorder and she had numbness in arms, but mostly in legs.  With CIDP, she felt tingling and numbness at times, but the sensation comes back.  However, since 9th November 2021, she had no sensation in left arm.  She explained that a couple of days ago from the day of reporting she was cutting something, and she accidentally stabbed her left hand.  She did not notice nor felt when she accidentally stabbed, she noticed when she started bleeding.  The patient read online about Guillain-Barre syndrome (GBS) with Shingrix. The patient was unsure whether she was experiencing GBS or whether it was worsening of CIDP.  Per the reporter, GBS was not diagnosed in her medical history.  She could not tell if the numbness was only in the left arm (where she received shingrix), or both arms. She also mentioned that before vaccination, her balance had not been good.  Since the vaccination the balance gotten worse, and harder to walk.  She was unsure if the vaccine had the impact on her walking or whether it's the worsening of CIDP. The patient felt numbness and tingling on 9th November 2021 at 4am.  She did not have the following information upon asking lot/exp date and dosage of shingrix. The symptoms were not resolved.  The reporter provided consent to follow-up.  However, the reporter did not have a phone/fax number or an email address to HCP.; Sender's Comments:  US-GLAXOSMITHKLINE-US2021AMR233737:Same reporter. Hearsay case.