Hypersensitivity reaction; incapacitated my ability to stand for 2 hours; Pain in the lelft knee; muscle twitches in the biceps of the left arm.; palpitations; there is scarring in these areas; I developed a burning, itching and painful rash on my neck and shoulders.; I developed a burning, itching and painful rash on my neck and shoulders.; I developed a burning, itching and painful rash on my neck and shoulders.; splotches of skin discolorations on my upper arms and all over my back; muscle/bone pain; muscle cramps; weakness; muscle/bone pain; This spontaneous case was reported by a consumer (subsequently medically confirmed) and describes the occurrence of MUSCLE SPASMS (muscle cramps), ASTHENIA (weakness), SKIN DISCOLOURATION (splotches of skin discolorations on my upper arms and all over my back), PRURITUS (I developed a burning, itching and painful rash on my neck and shoulders.) and RASH PRURITIC (I developed a burning, itching and painful rash on my neck and shoulders.) in a 71-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 027B21A and 027A21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     Concurrent medical conditions included Diabetes and Hypertension. Concomitant products included METFORMIN, AMLODIPINE, HYDROCHLOROTHIAZID, LOSARTAN and ATORVASTATIN for an unknown indication.   On 05-Mar-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 01-Apr-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. On 13-Apr-2021, the patient experienced MUSCLE SPASMS (muscle cramps) and ASTHENIA (weakness). 13-Apr-2021, the patient experienced BONE PAIN (muscle/bone pain) and MYALGIA (muscle/bone pain). On 08-Jun-2021, the patient experienced SKIN DISCOLOURATION (splotches of skin discolorations on my upper arms and all over my back). On 27-Jun-2021, the patient experienced PRURITUS (I developed a burning, itching and painful rash on my neck and shoulders.) and RASH PRURITIC (I developed a burning, itching and painful rash on my neck and shoulders.). 27-Jun-2021, the patient experienced RASH (I developed a burning, itching and painful rash on my neck and shoulders.). On 01-Jul-2021, the patient experienced SCAR (there is scarring in these areas). On an unknown date, the patient experienced HYPERSENSITIVITY (Hypersensitivity reaction), DYSSTASIA (incapacitated my ability to stand for 2 hours), PAIN (Pain in the lelft knee), MUSCLE TWITCHING (muscle twitches in the biceps of the left arm.) and PALPITATIONS (palpitations). The patient was treated with TOCOPHEROL (VITAMIN E [TOCOPHEROL]) (topical) for Itchy rash, at a dose of 1 dosage form and METHYLPREDNISOLONE from 12-Jul-2021 to 18-Jul-2021 for Hypersensitivity reaction, at a dose of 4 mg. At the time of the report, MUSCLE SPASMS (muscle cramps), ASTHENIA (weakness), SKIN DISCOLOURATION (splotches of skin discolorations on my upper arms and all over my back) and PAIN (Pain in the lelft knee) had not resolved, PRURITUS (I developed a burning, itching and painful rash on my neck and shoulders.), RASH PRURITIC (I developed a burning, itching and painful rash on my neck and shoulders.) and HYPERSENSITIVITY (Hypersensitivity reaction) had resolved and SCAR (there is scarring in these areas), BONE PAIN (muscle/bone pain), DYSSTASIA (incapacitated my ability to stand for 2 hours), MUSCLE TWITCHING (muscle twitches in the biceps of the left arm.), PALPITATIONS (palpitations), RASH (I developed a burning, itching and painful rash on my neck and shoulders.) and MYALGIA (muscle/bone pain) outcome was unknown.            Brief relief for the burning, itching and painful rash on the patient's neck and shoulders was obtained through the use of ice packs and vitamin E topical oil..    Most recent FOLLOW-UP information incorporated above includes: On 25-Jul-2021: Significant FU -Reporter information, Patient details, product information, Concomitant medications were updated and new events were added and also event outcome  details were updated