2 very small non tender palpable nodules/6 weeks later the nodules were larger/few weeks ago the areas had grown in size on the right cheek and were now visible when the skin was stretched; This spontaneous case was reported by a physician and describes the occurrence of SKIN MASS (2 very small non tender palpable nodules/6 weeks later the nodules were larger/few weeks ago the areas had grown in size on the right cheek and were now visible when the skin was stretched) in a 66-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination.     Concomitant products included POLY-L-LACTIC ACID (SCULPTRA) from 06-Sep-2021 to an unknown date for an unknown indication.   On 22-Jan-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 19-Feb-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 23-Oct-2021, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 06-Sep-2021, the patient experienced SKIN MASS (2 very small non tender palpable nodules/6 weeks later the nodules were larger/few weeks ago the areas had grown in size on the right cheek and were now visible when the skin was stretched). The patient was treated with TRIAMCINOLONE ACETONIDE (KENALOG [TRIAMCINOLONE ACETONIDE]) (intralesional) ongoing since an unknown date at an unspecified dose and frequency. At the time of the report, SKIN MASS (2 very small non tender palpable nodules/6 weeks later the nodules were larger/few weeks ago the areas had grown in size on the right cheek and were now visible when the skin was stretched) had not resolved.        For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown), the reporter did not provide any causality assessments.   No medical history information was reported.  She looks like she had HIV related lipoatrophy but she did not, likely just extremely low body weight/fat. The recommendation was for approx. 8 vials of Sculptra, 1 at a time with about 8 weeks in between sessions. Massage for 5 days was discussed and demonstrated for the patient. At her 7th session on 06-Sep-2021, there were 2 very small non tender palpable nodules that were noted. Physician avoided them on injection and discussed with the patient that would need to monitor. They proceeded that day with her Sculptra, she always do 1 vial at a time, with 9cc total dilution and left at room temperature for 7 days prior to injection. When physician saw her about 6 weeks later the nodules were larger and physician decided not to do any further Scultpra. Physician did several sessions of ILK which did not resolve the areas but did keep them from growing. They decided to watch and wait since they were not tender or growing, and not visible from the outside but when physician saw her back a few weeks ago the areas had grown in size on the right cheek and were now visible when the skin was stretched. Physician did another session of ILK, but she was now very concerned that they would not resolve without excision. On an unknown date the patient had an intralesional injection of Kenalog with saline.