Now, Period is Two weeks late (after Second Shot); Late Period after Second Shot; Weight Gain  after Second Shot/rapid weight gain; Period Bleeding 2 weeks straight  after Second Shot; Tired  after Second Shot/Fatigue  after Second Shot; Achy  after Second Shot/Felt like a Ton of Bricks  after Second Shot; Crawled to the bathroom  after Second Shot; Felt like a Ton of Bricks after Second Shot; Menstrual Cycle  messed up and changed  after Second Shot/Now, Period is Two weeks late  (after Second Shot)/a messed up menstrual cycle; This spontaneous case was reported by a patient and describes the occurrence of FATIGUE (Tired  after Second Shot/Fatigue  after Second Shot), PAIN (Achy  after Second Shot/Felt like a Ton of Bricks  after Second Shot), GAIT DISTURBANCE (Crawled to the bathroom  after Second Shot), DISCOMFORT (Felt like a Ton of Bricks after Second Shot) and MENSTRUATION IRREGULAR (Menstrual Cycle  messed up and changed  after Second Shot/Now, Period is Two weeks late  (after Second Shot)/a messed up menstrual cycle) in a 45-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch no. 006B21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     No Medical History information was reported.    On 31-Mar-2021, the patient received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 31-Mar-2021, the patient experienced FATIGUE (Tired  after Second Shot/Fatigue  after Second Shot), PAIN (Achy  after Second Shot/Felt like a Ton of Bricks  after Second Shot), GAIT DISTURBANCE (Crawled to the bathroom  after Second Shot) and MENSTRUATION IRREGULAR (Menstrual Cycle  messed up and changed  after Second Shot/Now, Period is Two weeks late  (after Second Shot)/a messed up menstrual cycle). 31-Mar-2021, the patient experienced DISCOMFORT (Felt like a Ton of Bricks after Second Shot). In April 2021, the patient experienced MENSTRUATION DELAYED (Late Period after Second Shot  ), WEIGHT INCREASED (Weight Gain  after Second Shot/rapid weight gain) and MENSTRUAL DISORDER (Period Bleeding 2 weeks straight  after Second Shot). On 22-Jun-2021, the patient experienced MENSTRUATION DELAYED (Now, Period is Two weeks late (after Second Shot)). The patient was treated with PARACETAMOL (TYLENOL) at a dose of 1 dosage form. On 01-Apr-2021, FATIGUE (Tired  after Second Shot/Fatigue  after Second Shot), PAIN (Achy  after Second Shot/Felt like a Ton of Bricks  after Second Shot), GAIT DISTURBANCE (Crawled to the bathroom  after Second Shot) and DISCOMFORT (Felt like a Ton of Bricks after Second Shot) had resolved. At the time of the report, MENSTRUATION IRREGULAR (Menstrual Cycle  messed up and changed  after Second Shot/Now, Period is Two weeks late  (after Second Shot)/a messed up menstrual cycle), MENSTRUATION DELAYED (Late Period after Second Shot  ), WEIGHT INCREASED (Weight Gain  after Second Shot/rapid weight gain), MENSTRUAL DISORDER (Period Bleeding 2 weeks straight  after Second Shot) and MENSTRUATION DELAYED (Now, Period is Two weeks late (after Second Shot)) outcome was unknown.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On an unknown date, Hormone level abnormal: normal (normal) normal. On an unknown date, Smear cervix: normal (normal) normal. On an unknown date, Thyroid function test: normal (normal) normal.         Action taken with mRNA-1273 Moderna COVID-19 Vaccination was Not applicable.  No Concomitant medication was provided.   Most recent FOLLOW-UP information incorporated above includes: On 23-Jun-2021: Non significant follow-up information received on 23-june-2021