aches keep coming and going, on and off; massive headache; weird pulling feeling on both of her legs/like a light switch; burning sensation in her nose; lips swelled up; weird feeling on the edges of her tongue; she felt off; tongue swelled up; blisters on the tip of her tongue; hasn't been feeling right; face was itchy/ skin was itchy; inner ears were itchy; This is a spontaneous report from a contactable consumer (patient). A 46-year-old female patient received the first dose of BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE, batch/lot number and expiration date unknown) via an unspecified route of administration at left arm on 31Mar2021 at 09:30 (46-year-old at time of vaccination), at single dose, for COVID-19 immunization. The patient's medical history included ongoing MTHFR (genetic thing called MTHFR. She has trouble digesting synthetic vitamins and folic acid), IVF, COVID-19 virus in Mar2020. Patient had no known or documented allergies. Concomitant medications included monascus purpureus (RED YEAST RICE) and multivitamin (unspecified). The patient previously received famotidine from an unspecified date to 2021 (stopped several weeks before). Patient reported after receiving the COVID-19 vaccine her tongue swelled up and she hasn't been feeling right since she got the vaccine. When asking caller to clarify what she meant when she reported "not feeling right" she reports she didn't feel right immediately after getting the COVID-19 vaccine. On day 1 of getting the COVID 19 vaccine, 31Mar2021, her face was itchy but her face wasn't red, she had no rash or hives; her inner ears were itchy and her skin was itchy. She got the COVID-19 vaccine at 9:30 and an hour or two later her tongue swelled up. She took diphenhydramine hydrochloride (BENADRYL). She also had blisters on the tip of her tongue. The next day, 01Apr2021, the swelling had subsided but she still had a weird feeling on the edges of her tongue. It felt weird. Her tongue was not red or swollen at that time. On 01Apr2021 she felt off. Then on day 3, 02Apr2021 she had a burning sensation in her nose and her lips swelled up. On Saturday, 03Apr2021 she went to(visit to physician office) because she had a weird pulling feeling on both of her legs. The pulling feeling on her legs was like a light switch. The feeling was going on all day 03Apr2021. Then the next day, Sunday 04Apr2021, the pulling sensation on her legs was gone but she did wake up with a massive headache. She had the headache since 04Apr2021 morning. She's been having these symptoms since she received the COVID-19 vaccine and she can't attribute the symptoms to anything else. She's also had aches throughout this whole process and the aches keep coming and going, on and off. She still feels a weird thing on her tongue but she can't see anything on her tongue. She'd be in a better place except for her headache. She never had a fever. She was expecting to have flu like symptoms after getting the COVID-19 vaccine. She didn't have any of those symptoms. When probing medical history and concomitant medications she reports she's been to an allergist and she has no documented allergies. Her doctors are aware of the symptoms she's been having since she received the COVID-19 vaccine. There is something, she does know she has a genetic thing called MTHFR. She has trouble digesting synthetic vitamins and folic acid. She knows she has this genetic thing because she went through IVF to have her children and the MTHFR came up on one of the blood panels. She can't break down certain vitamins so she has to avoid anything that has folic acid in it and she can't take vitamins with folic acid in it. She reports she took no medications on the same day that she received her COVID-19 vaccine. She reports she used to take Famotidine but stopped taking it several weeks ago. She did go to the physician's office because she got really nervous when she had the pulling sensation on her legs. The physician's office had no explanation and nothing to really report. The physician's office told her to contact the CDC. She is asking if she's had an allergic reaction and should she even consider getting the second COVID-19 vaccine. Therapeutic measures were taken as a result of the events and included diphenhydramine hydrochloride. The outcome of massive headache was not recovered; tongue swelled up was recovered on 01Apr2021; weird pulling feeling on both of her legs/like a light switch was recovered on 04Apr2021; outcome of other events was recovering.  Information on the lot/batch number has been requested.