Patient had COVID on Dec 26 2022 and also had a rebound of COVID; Being sick twice as she also got sick on Jan 6 2022; This spontaneous case was reported by a patient family member or friend and describes the occurrence of COVID-19 (Patient had COVID on Dec 26 2022 and also had a rebound of COVID) and ILLNESS (Being sick twice as she also got sick on Jan 6 2022) in a 64-year-old female patient who received mRNA-1273 BIVALENT .222 (MODERNA COVID-19 VACCINE, BIVALENT (ORIGINAL AND OMICRON BA.4/BA.5)) (batch no. AF7140C) for COVID-19 prophylaxis.     Concurrent medical conditions included Factor V Leiden thrombophilia. Concomitant products included LEVOTHYROXINE SODIUM (SYNTHROID), LIOTHYRONINE and APIXABAN (ELIQUIS) for an unknown indication.    On 09-Sep-2022, the patient received fifth dose of mRNA-1273 BIVALENT .222 (MODERNA COVID-19 VACCINE, BIVALENT (ORIGINAL AND OMICRON BA.4/BA.5)) (unknown route) 1 dosage form. On 06-Jan-2022, the patient experienced ILLNESS (Being sick twice as she also got sick on Jan 6 2022). On 26-Dec-2022, the patient experienced COVID-19 (Patient had COVID on Dec 26 2022 and also had a rebound of COVID). The patient was treated with NIRMATRELVIR, RITONAVIR (PAXLOVID) on 27-Dec-2022 for COVID-19, at an unspecified dose and frequency and GUAIFENESIN (MUCINEX) ongoing since an unknown date for COVID-19, at a dose of Daily, qd. At the time of the report, COVID-19 (Patient had COVID on Dec 26 2022 and also had a rebound of COVID) had resolved and ILLNESS (Being sick twice as she also got sick on Jan 6 2022) outcome was unknown.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On an unknown date, SARS-CoV-2 test: Positive.     For mRNA-1273 BIVALENT .222 (MODERNA COVID-19 VACCINE, BIVALENT (ORIGINAL AND OMICRON BA.4/BA.5)) (Unknown), the reporter did not provide any causality assessments.   It was unknown if patient received any other vaccines in the 4 weeks prior to COVID-19 vaccine administration.  Caller and his wife on the phone mentioned they both received primary series of the Moderna COVID-19 vaccine and boosters and wanted to travel overseas and wanted to know if there is a future shot coming out as they were going to Europe in April and they received the last shot was Bivalent on 09-Sep-2022.  Caller stated they were worried about it wearing off. They had a very serious health condition. The husband had a cardiac arrest in 2010 and cardiovascular disease. Caller's wife had COVID about a month ago, it ended but the husband did not had an COVID, neither its symptom. Both were 64 years old, and his wife had a health condition of Factor V Leiden- a blood clotting condition. Patient had COVID on Dec 26 2022 and also had a rebound of COVID, she ended up being sick twice as she also got sick on Jan 6 2022, she tested positive again.   Caller received the following doses 1st dose of Moderna booster on 20-Mar-2021 lot no. 045a21a, 2nd dose on 17-Apr-2021 lot no. 042b21a, on 19-Sep-2021 Moderna booster lot# 020f21a, on 19-Sep-2022 Moderna booster lot no. 042321a, on 09-Sep-2022 bivalent Moderna Booster lot no. AF7140C.  Caller stated that the vaccination wain's after 4 months and it's not as strong if you're older, like us, we're 64. They had these underlying health conditions that could be very serious if they get COVID.  Patient was treated with Paxlovid from 27-Dec-2022, as well as Mucinex dm for COVID.