Transverse Myelitis/Acute Myelitis transverse; Spinal cord inflammation and infection; Spinal cord inflammation and infection; Hepatitis; burning and tingling in legs (feels like is skin); Focal motor seizure; edema associated with the superior cerebellar peduncles bilaterally.; Bilateral radiating leg pain; Spasm; extremity weakness/weakness lower legs/lower extremity weakness; tremors upper extremities and hands; paresthesias; Abdominal distension; burning and tingling in legs (feels like is skin); Acute Disseminated Encephalomyelitis (ADEM).; numbness of both legs/Numbness of perineum/Bilateral Leg Numbnes/numbness to bilateral lower extremities; This case was reported by a lawyer and described the occurrence of myelitis transverse in a patient who received Herpes zoster (Shingrix) for prophylaxis.   On an unknown date, the patient received Shingrix. On an unknown date, an unknown time after receiving Shingrix, the patient experienced myelitis transverse (serious criteria GSK medically significant) and acute disseminated encephalomyelitis (serious criteria GSK medically significant). The action taken with Shingrix was unknown. On an unknown date, the outcome of the myelitis transverse and acute disseminated encephalomyelitis were unknown.   It was unknown if the reporter considered the myelitis transverse and acute disseminated encephalomyelitis to be related to Shingrix.  Initial information received on 3 April 2020 via medical record. As per Consult Notes dated 14 September 2018 patient did have the 1st of a 2 dose series of a shingles vaccination (Shingrix) within the past month. The patient had acute disseminated encephalomyelitis on 7 December 2018.The patient had numbness of both legs up to the groin on 1 September 2018. The patient admitted on 2 September 2018 and discharged on 3 September 2018 and as per discharge summary she had Numbness of perineum, Acute transverse myelitis, Bilateral radiating leg pain The patient also had febrile illness hepatitis spinal cord inflammation and infection, Patient with fullness sensation in abdomen and burning and tingling in legs (feels like is skin) on 2 September 2018 and extremity weakness 2 september 2018. She also had weakness lower legs, tremors upper extremities and hands and Bilateral radiating leg pain and bilateral leg numbness, spasms, pain on 3 September 2018.Complaining of lower extremity weakness on 6 September 2018 and numbness to bilateral lower extremities on 9 September 2018 . Focal motor seizure as per consultant notes dated on 28 October 2018. She had history of surgery for cerebral aneurysm. The patient also had complaint of bilateral leg numbness and she was able to walk and denied weakness but states her legs are numb and the cramps were making walking difficult. The patient also had Abdominal distension onset date was 2 Sep 2018 Spasm onset date was 3 Sep 2018,Pain onset date was 3 Sep 2018 Febrile illness and Hepatitis and Spinal cord inflammation and infection. Ct spine (lumbar)without and with contrast done on 3 September 2018 for paresthesias and weakness. MRI of the brain shows inflammatory changes about the superior cerebellum that are similar to the finding in September.MR brain without and with contrast history, HSV encephalomyelitis/ R arm shaking and left arm weakness comparison done on 6 September 2018 and it revealed edema associated with the superior cerebellar peduncles bilaterally      Lab Comments: Ct spine (lumbar)without and with contrast done on 3 September 2018 for paresthesias and weakness. MRI of the brain shows inflammatory changes about the superior cerebellum that are similar to the finding in September.MR brain without and with contrast history, HSV encephalomyelitis/ R arm shaking and left arm weakness comparison done on 6 September 2018 and it revealed edema associated with the superior cerebellar peduncles bilaterally.