Low Blood Pressure; Had a heart attack; Very Dizzy; Hot; Very Weak; Very Sick; Eye Color changed; sharp pain behind the right eye; COVID ARM From injection site to elbow; COVID ARM Itchy From injection site to elbow; Swollen Lymph Node; COVID ARM Red Rash From injection site to elbow; COVID ARM Red Rash From injection site to elbow; This spontaneous case was reported by a patient and describes the occurrence of MYOCARDIAL INFARCTION (Had a heart attack) and HYPOTENSION (Low Blood Pressure) in a 62-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 042B21-2A and 021B21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     No Medical History information was reported.   On 31-Mar-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 28-Apr-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. On 28-Apr-2021, the patient experienced ILLNESS (Very Sick), EYE COLOUR CHANGE (Eye Color changed ), EYE PAIN (sharp pain behind the right eye), LYMPHADENOPATHY (Swollen Lymph Node), VACCINATION SITE ERYTHEMA (COVID ARM Red Rash From injection site to elbow) and VACCINATION SITE RASH (COVID ARM Red Rash From injection site to elbow). 28-Apr-2021, the patient experienced VACCINATION SITE REACTION (COVID ARM From injection site to elbow) and VACCINATION SITE PRURITUS (COVID ARM Itchy From injection site to elbow). On 14-Jul-2021, the patient experienced MYOCARDIAL INFARCTION (Had a heart attack) (seriousness criteria hospitalization and medically significant), DIZZINESS (Very Dizzy), FEELING HOT (Hot) and ASTHENIA (Very Weak). On an unknown date, the patient experienced HYPOTENSION (Low Blood Pressure) (seriousness criterion hospitalization). The patient was hospitalized from 14-Jul-2021 to 16-Jul-2021 due to HYPOTENSION and MYOCARDIAL INFARCTION. The patient was treated with DIPHENHYDRAMINE HYDROCHLORIDE (BENADRYL [DIPHENHYDRAMINE HYDROCHLORIDE]) ongoing since an unknown date for Rash, at a dose of 1 dosage form. On 30-Apr-2021, ILLNESS (Very Sick), VACCINATION SITE REACTION (COVID ARM From injection site to elbow), VACCINATION SITE PRURITUS (COVID ARM Itchy From injection site to elbow), LYMPHADENOPATHY (Swollen Lymph Node), VACCINATION SITE ERYTHEMA (COVID ARM Red Rash From injection site to elbow) and VACCINATION SITE RASH (COVID ARM Red Rash From injection site to elbow) had resolved. On 16-Jul-2021, MYOCARDIAL INFARCTION (Had a heart attack) had resolved. At the time of the report, HYPOTENSION (Low Blood Pressure), DIZZINESS (Very Dizzy), FEELING HOT (Hot) and ASTHENIA (Very Weak) outcome was unknown and EYE COLOUR CHANGE (Eye Color changed ) and EYE PAIN (sharp pain behind the right eye) had not resolved.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On 14-Jul-2021, Myocardial necrosis marker: high (High) HIGH. On an unknown date, Blood pressure measurement: low (Low) low.     For mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular), the reporter did not provide any causality assessments.   No concomitant medication information was provided by the reporter.  Patient reported that her eye color changed from hazel to blue and reported to have a yellow ring around the blue color. She also stated that when she fell dizzy and hot while doing the yard work she called in 911 for ambulance and was transported to emergency room and thereon was hospitalized.   Patient reported that the paramedics did not give her any medication for her low blood pressure.  Based on current available information and the temporal association between product use and the start date of the events a causal relationship cannot be excluded.; Sender's Comments: Based on current available information and the temporal association between product use and the start date of the events a causal relationship cannot be excluded.