This is a spontaneous report received from a contactable reporter(s) (Other HCP) from medical information team, Program ID: (159558). The reporter is the patient. A 68-year-old female patient received BNT162b2 (BNT162B2), on 17Aug2022 as dose 4 (booster), single (Batch/Lot number: unknown) for covid-19 immunisation. The patient's relevant medical history included: "Autoimmune disease" (unspecified if ongoing), notes: I have an autoimmune disease. The patient's concomitant medications were not reported. Vaccination history included: Covid-19 vaccine (Dose:1, unknown manufacturer), for COVID-19 Immunization; Covid-19 vaccine (Dose:2, unknown manufacturer), for COVID-19 Immunization; Covid-19 vaccine (Dose:3, unknown manufacturer, After my third COVID shot which would be my first booster shot), for COVID-19 Immunization; Shingles vaccine (I got my first shingles vaccine), for Immunization. The following information was reported: BLISTER (non-serious) with onset 2022, outcome "unknown", described as "I had a very mild blister behind my ear"; HEADACHE (non-serious) with onset 2022, outcome "unknown", described as "I have terrible headache"; HERPES ZOSTER (non-serious) with onset 2022, outcome "unknown", described as "I´m getting a shingles outbreak"; MALAISE (non-serious) with onset 2022, outcome "unknown", described as "not feeling well"; NASAL DISCOMFORT (non-serious) with onset 2022, outcome "unknown", described as "´developed sores inside my nose". Additional information: The patient had Pfizer vaccine, it was fourth shot, second booster, patient had it two days ago and now patient getting a shingles outbreak and patient want to know if patient he can get my shingles antiviral medication or would that interfere with the effectiveness of the vaccine, because it's an antiviral. The problem is, by Monday I'll have a full blown shingles attack and right now patient can nip it in the bud, but patient didn't want to go through the trouble of taking a vaccine and then not having it to be effective. patient had a preexisting problem with shingles, patient would get one or two outbreaks a year and they weren't very bad. After my third COVID shot which would be my first booster shot, patient had shingles for months and I was on antivirals constantly for months and patient was afraid to get this fourth shot because of that. patient finally cleared it up, and then patient got my first shingles vaccine, patient waited six weeks and then patient got my booster shot and it's two days later and patient have slight little signs of an outbreak. Its in my head, that's why I'm irritable patient have terrible headache and patient felt that the minute patient got the shot and now I've developed sores inside my nose and that seems to be spreading inside my nose and patient had a very mild blister behind my ear. patient have been prescribed antivirals to keep in my house so patient can use them immediately and they don't have to get to be serious attacks and patient just don't want to take it if it is going to prevent me for building the same amounts of antibodies from the vaccine that patient would build if I didn't take it. patient have an autoimmune disease, chances are I'd have a cold but I might get long COVID because my immune system is wacky". Can I get my shingles antiviral medication or would that interfere with the effectiveness of the vaccine. The information on the batch/lot number for BNT162b2 has been requested and will be submitted if and when received.