Covid-19; This spontaneous case was reported by a patient and describes the occurrence of COVID-19 (Covid-19) in a 43-year-old male patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch no. 031h21a) for COVID-19 vaccination.     Concurrent medical conditions included Drug allergy (The patient had allergy to unknown past drug).    On 07-Dec-2021 at 12:00 PM, the patient received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. In May 2022, the patient experienced COVID-19 (Covid-19). The patient was treated with NIRMATRELVIR, RITONAVIR (PAXLOVID) from 12-May-2022 to 16-May-2022 for COVID-19 treatment, at an unspecified dose and frequency. At the time of the report, COVID-19 (Covid-19) was resolving.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On an unknown date, SARS-CoV-2 test: negative (Negative) Negative, positive (Positive) Positive and positive (Positive) Positive.         No concomitant medication was reported.  The patient had not taken any other medications within 2 weeks of starting COVID-19 treatment.  The patient's symptoms of COVID included intense sore throat, chills, body aches, headaches. Everything expect sore throat had cleared up the day after finishing Paxlovid. Sore throat stopped a couple of days later. 12 days after finishing treatment, patient had a rebound effect with symptoms as runny/ stuffy nose and fatigue. Patient took a home test which came up positive and did a second test a few hours later with same result. Patient had symptoms for three more days and tested again on day 15 (after finishing medications) with negative result. Company comment: This spontaneous case concerns a 43-year-old male patient, with no relevant medical history, who experienced the unexpected, non-serious of COVID-19, approximately 5 months after the third dose of mRNA-1273 vaccine. No details of previous doses were provided. As per source document, he experienced intense sore throat, chills, body aches and headaches and he received Paxlovid as COVID-19 treatment. Everything cleared up the day after finishing Paxlovid, except sore throat that stopped a couple of days later. Twelve days after finishing treatment, he had a rebound effect with runny nose and fatigue. He had two positive home tests and tested again after finishing medications with negative result. The benefit-risk relationship of mRNA-1273 is not affected by this report. Sender's Comments: This spontaneous case concerns a 43-year-old male patient, with no relevant medical history, who experienced the unexpected, non-serious of COVID-19, approximately 5 months after the third dose of mRNA-1273 vaccine. No details of previous doses were provided. As per source document, he experienced intense sore throat, chills, body aches and headaches and he received Paxlovid as COVID-19 treatment. Everything cleared up the day after finishing Paxlovid, except sore throat that stopped a couple of days later. Twelve days after finishing treatment, he had a rebound effect with runny nose and fatigue. He had two positive home tests and tested again after finishing medications with negative result. The benefit-risk relationship of mRNA-1273 is not affected by this report.