This spontaneous case was reported by a consumer and describes the occurrence of IMMUNISATION REACTION (REACTIONS TO ALL THREE COVID VACCINES), PARADOXICAL DRUG REACTION (HUMIRA WAS DOING THE OPPOSITE OF WHAT IT WAS SUPPOSED TO DO), ARTHRITIS (Joint inflammation) and COVID-19 (COVID-19) in a 62-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination. Co-suspect product included non-company product ADALIMUMAB (HUMIRA) solution for injection for Plaque psoriasis. No Medical History information was reported. In 2022, the patient started ADALIMUMAB (HUMIRA) (Subcutaneous) Citrate Free, pre-filled pen. On an unknown date, the patient received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On an unknown date, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form and first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. In 2022, the patient experienced IMMUNISATION REACTION (REACTIONS TO ALL THREE COVID VACCINES), PARADOXICAL DRUG REACTION (HUMIRA WAS DOING THE OPPOSITE OF WHAT IT WAS SUPPOSED TO DO), ARTHRITIS (Joint inflammation) and COVID-19 (COVID-19). In 2022, IMMUNISATION REACTION (REACTIONS TO ALL THREE COVID VACCINES) and COVID-19 (COVID-19) had resolved. At the time of the report, PARADOXICAL DRUG REACTION (HUMIRA WAS DOING THE OPPOSITE OF WHAT IT WAS SUPPOSED TO DO) and ARTHRITIS (Joint inflammation) outcome was unknown. No concomitant medications were reported. On an unspecified date in 2022, the blood work was performed and results were unknown. The information was unknown whether the patient was enrolled in a COVID-19 Vaccine Trial. The reporter's causality for the event(s) of Humira was doing the opposite of what it was supposed to do, reactions to all three COVID vaccines, joints inflammation and COVID was not provided against Humira. No treatment medications were reported. Company Comment: This is a spontaneous  case concerning  a  62-year-old, female patient with no reported medical history, who experienced the unexpected non-serious events of Immunisation reaction, Paradoxical drug reaction, Arthritis, COVID-19. The exact date of administration of third dose of mRNA-1273 and onset of the events was not specified, hence latency could not be assessed.  No further details on clinical course, lab test results and treatment received were reported. Outcome of the events was not resolved at the time of report. The benefit-risk relationship of mRNA-1273 Vaccine, is not affected by this report. Sender's Comments: This is a spontaneous  case concerning  a  62-year-old, female patient with no reported medical history, who experienced the unexpected non-serious events of Immunisation reaction, Paradoxical drug reaction, Arthritis, COVID-19. The exact date of administration of third dose of mRNA-1273 and onset of the events was not specified, hence latency could not be assessed.  No further details on clinical course, lab test results and treatment received were reported. Outcome of the events was not resolved at the time of report. The benefit-risk relationship of mRNA-1273 Vaccine, is not affected by this report.