bumps from her amyloidosis have almost disappeared; no pain from amyloidosis bumps; has feeling back in her feet; can move her toes again; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP). The reporter is the patient.  A 73 year-old female patient received bnt162b2 (BNT162B2), administered in arm right, administration date 23Feb2021 (Lot number: EL9266, Expiration Date: 31May2021) at the age of 73 years as dose 1, single and administered in arm right, administration date 16Mar2021 (Lot number: EN6207, Expiration Date: 31Jul2021) as dose 2, single for covid-19 immunisation. Relevant medical history included: "Amyloidosis" (unspecified if ongoing); "started losing feeling in her feet", start date: 1994 (unspecified if ongoing), notes: Caller says that she started losing feeling in her feet in 1994. There were no concomitant medications. Vaccination history included: Shingrix (Caller says they have not had any other recent vaccinations or started any new medications. She says that months before this she had the Shingrix vaccine, she thinks that was November of last year. Shingrix NDC/LOT/EXP Unknown.), administration date: Nov2020. The following information was reported: THERAPEUTIC RESPONSE UNEXPECTED (non-serious) with onset 23Feb2021, outcome "unknown", described as "bumps from her amyloidosis have almost disappeared; no pain from amyloidosis bumps; has feeling back in her feet; can move her toes again". Relevant laboratory tests and procedures are available in the appropriate section.  Additional information: She clarifies that her positive side effects started after getting this injection. She got the shot on a Monday (detail discrepant with information provided, but not noted till after call) then on Friday she realized that there were changes, things for the positive we don't really notice right away. She says that the positive effects began quite soon, within about four days of the first dose. She says she would like to know if it is unusual not to have felt anything where she got the shot. She says her doctors couldn't explain it, and her doctor said her immune system may be out of whack.  Pfizer COVID-19 vaccine had an interesting reaction. She says she has amyloidosis and is in a study for it, and she had the second vaccine shot this week and when she called the study doctor they suggested her to call to report. She says that she has had no side effects from the Pfizer COVID-19 vaccine except positive effects. She says all of the bumps from her amyloidosis have almost disappeared after her last vaccine dose on Wednesday, and she has no pain from them. She says that the bumps are a 10th of the size that they were and when she touches them they don't hurt. She says she also has feeling back in her feet, which she hasn't had since 1994, and she can move her toes which she couldn't move her toes on one foot at all, but now she can move them. She says she can't move them a lot, but she can move them. She says that it is just strange, she got the first Pfizer COVID-19 shot on a Tuesday, then on Friday she noticed things but she didn't put it together, it was strange.   No follow-up attempts are possible. No further information is expected.