The itchy rash got worse every time she had a vaccine; The itchy rash got worse every time she had a vaccine; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP). The reporter is the patient.  An 84-year-old female patient received BNT162b2 (BNT162B2), on 07Oct2021 as dose 3 (booster), single (Lot number: FE3590), in left arm and on 29Apr2022 as dose 4 (booster), single (Lot number: PJ4989) at the age of 84 years, in left arm for covid-19 immunisation. The patient's relevant medical history included: "Allergies" (unspecified if ongoing); "Allergies to Penicillin" (unspecified if ongoing). Concomitant medication(s) included: OLMESARTAN (ongoing); BYSTOLIC (ongoing); ZOCOR; CETIRIZINE taken for hypersensitivity (ongoing); FLUTICASONE (ongoing); IPRATROPIUM BROMIDE (ongoing); OMEPRAZOLE (ongoing); LORAZEPAM (ongoing); DILTIAZEM (ongoing). Past drug history included: Clonidine, reaction(s): "Allergies to Clonidine". Vaccination history included: BNT162b2 (Dose 1, Lot: EL9269, left arm), administration date: 06Feb2021, when the patient was 82-year-old, for COVID-19 Immunization; BNT162b2 (Dose 2, Lot: EN6201, left arm), administration date: 01Mar2021, when the patient was 82-year-old, for COVID-19 immunization. The following information was reported: RASH PRURITIC (non-serious), CONDITION AGGRAVATED (non-serious) all with onset Dec2021, outcome "not recovered" and all described as "The itchy rash got worse every time she had a vaccine". The event "the itchy rash got worse every time she had a vaccine" required physician office visit. Relevant laboratory tests and procedures are available in the appropriate section. Therapeutic measures were taken as a result of rash pruritic, condition aggravated.  Additional information: She had the 2 Pfizer BioNTech Covid-19 Vaccine doses and then 2 booster doses. Then she got COVID. She was prescribed Paxlovid. However she reported that since the first series of the vaccine she has had this itchy rash all over her legs, arms and body that is like getting hives. She reported her doctor gave her antibiotic but it would not go away. She called Pfizer for recommendations on what to do. Insurers cannot give her any recommendations. Caller clarified that she has had 4 doses of Pfizer BioNTech Covid-19 Vaccine including 2 standard doses and 2 booster doses. She clarified that she has had COVID twice since getting Pfizer Covid-19 Vaccine; the first was before her second booster dose; and the second was after her second booster dose. She has lasting effect from second bout of COVID of dry cough which she never had before. She reported onset of the itchy rash all over her legs, arms and body that is like getting hives was about a week or so after her first bout of COVID. She verified other information provided. Doctor gave her the antibiotic in Dec2021 when she had COVID thinking it was hives and it did not work. She does not know the name of the antibiotic, she only had it for a week or so in Dec2021. The itchy rash gets worse when you get COVID. She still has the itching, she does not know if it is hives or what it is but it is very annoying. The itchy rash got worse every time she had a vaccine and then when she had Paxlovid it really made the hives itch. Completed prescribed therapy as far as they have advised so far. Regarding treatment and medical interventions they gave her the infusion for COVID on 09Dec2021. She started Paxlovid 02Aug2022. Then she tested negative for COVID on 05Aug2022 so she stopped the Paxlovid 05Aug2022, that was the date she took the last Paxlovid.