Shingles after received both doses/Suspected vaccination failure; Shingles (ER); Skin infection; This serious case was reported by a consumer via call center representative and described the occurrence of vaccination failure in a 66-year-old male patient who received Herpes zoster (Shingrix) for prophylaxis.   Co-suspect products included Herpes zoster (Shingrix) for prophylaxis.   Concurrent medical conditions included hiv positive. Concomitant products included acyclovir.   On an unknown date, the patient received the 2nd dose of Shingrix and the 1st dose of Shingrix. On an unknown date, less than a year after receiving Shingrix and less than 2 years after receiving Shingrix, the patient experienced vaccination failure (Verbatim: Shingles after received both doses/Suspected vaccination failure) (serious criteria GSK medically significant), shingles (Verbatim: Shingles (ER)) and skin infection (Verbatim: Skin infection). The outcome of the vaccination failure, shingles and skin infection were not recovered/not resolved.   It was not reported if the reporter considered the vaccination failure, shingles and skin infection to be related to Shingrix and Shingrix.     It was not reported if the company considered the vaccination failure, shingles and skin infection to be related to Shingrix and Shingrix.   Additional Information: GSK receipt date: 06-MAR-2023 The reporter was the patient.  The patient received 2 doses of Shingrix shot and patient did not know the exact dates.  The reporter thought that shot 1 was toward the end of 2020 and shot 2 was toward the beginning of 2021.  He did provided his pharmacy's contact information and physician's contact information which should have the dates and lot numbers on file. The outbreak of shingles that he had during the hurricane was after he had received both Shingrix shots. The reporter stated that he just wondered if you had any suggestions for him. The reporter did not thought that the Shingrix vaccine worked that well for him. The patient's dermatologist helped him realize only recently that had outbreaks for decades. The patient thought it was herpes because that and what a doctor said a very long time ago. The patient do understand they were in the same family or whatever, but he did not thought that he had shingles. The patient had always taken acyclovir when he would had these outbreaks so it was never full blown.  The patient was HIV positive but did not thought that think my doctor considered me immunocompromised, exactly. The patient was trying to had an outbreak now. The patient thought it was happening in the last several months.  The patient know that he had an outbreak when he ran from hurricane (end of August 2021) and he ended up in the emergency room out of town with a skin infection and an outbreak (or the beginning). He said it was shingles and prescribed 800 mg acyclovir twice a day. The patient thought he was wrong, but he was not and would take the vaccine again, but he did not believe it. The patient's physician wanted to take the old vaccine first, then the Shingrix, but the old one was not available.  This case was considered as suspected vaccination failure as details regarding laboratory confirmation regarding shingles were unknown at the time of reporting.