Recurrence now of lymphoma/ The lymphoma came back again; This spontaneous case was reported by a patient and describes the occurrence of LYMPHOMA (Recurrence now of lymphoma/ The lymphoma came back again) in a 74-year-old male patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 027H21B, 012M20A and 029L20A) for COVID-19 prophylaxis.     The patient's past medical history included Chemotherapy (Chemo before they got the vaccine). Concurrent medical conditions included Cancer and Heart disorder (Patient was taking heart medication). Concomitant products included ZANUBRUTINIB for Cancer.   On 25-Jan-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 22-Feb-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 30-Nov-2021, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On an unknown date, the patient experienced LYMPHOMA (Recurrence now of lymphoma/ The lymphoma came back again) (seriousness criterion medically significant). At the time of the report, LYMPHOMA (Recurrence now of lymphoma/ The lymphoma came back again) was resolving.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On 03-Aug-2022, SARS-CoV-2 antibody test: 14,622.1 (High). It was supposed to be less than or equal to 50 range, 16.50 S/Co (high) and 0.01 SCo.         Concomitant medication included unspecified heart medications. No treatment medication information was reported.  Patient was feeling well and lymphoma was under control at the moment.  Patient was in remission for the Chemo before getting the vaccination. The lymphoma came back again in January.  Company comment- This spontaneous case concerns a 74-year-old male patient with relevant medical history of Cancer, who experienced unexpected, serious (medically significant) event of Lymphoma (reported as Recurrence now of lymphoma/ The lymphoma came back again), which occurred at an unknown time with regards to the mRNA-1273 vaccination. He is taking Zanubrutinib for the cancer and some heart medication. He also reported doing a test called the Quant Spike for SARS-Covid 2 IgG 9 months after vaccination, with elevated results. The outcome of the events was reported as resolving. The relevant medical history of cancer is a risk factor to the event The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report.   Most recent FOLLOW-UP information incorporated above includes: On 01-Sep-2022: Live follow-up appended: Narrative was updated.; Sender's Comments: This spontaneous case concerns a 74-year-old male patient with relevant medical history of Cancer, who experienced unexpected, serious (medically significant) event of Lymphoma (reported as Recurrence now of lymphoma/ The lymphoma came back again), which occurred at an unknown time with regards to the mRNA-1273 vaccination. He is taking Zanubrutinib for the cancer and some heart medication. He also reported doing a test called the Quant Spike for SARS-Covid 2 IgG 9 months after vaccination, with elevated results. The outcome of the events was reported as resolving. The relevant medical history of cancer is a risk factor to the event The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report.