anaphylaxis; fever of 100; my right arm where the vaccine was given is rock hard bit red; right arm where the vaccine was given is rock hard bit red it has eczema, and it is quite painful; right arm where the vaccine was given is rock hard bit red it has eczema, and it is quite painful; right arm where the vaccine was given is rock hard bit red it has eczema, and it is quite painful; Chills; terrible fatigue; Joint pain; Muscle pain; This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP) from medical information team. The reporter is the patient.  A 35-year-old female patient received pneumococcal 20-val conj vac (dipht CRM197 protein) (PREVNAR 20), in Oct2022 as dose number unknown, single (Batch/Lot number: unknown) at the age of 35 years, in right arm for immunisation. The patient's relevant medical history included: "Ehlers-Danlos syndrome" (ongoing); "mast cell activation syndrome" (ongoing); "Angiosarcoma on my pancreas" (ongoing); "cancer" (ongoing). Concomitant medication(s) included: CROMOLYN SODIUM resp inhalation taken for mast cell activation syndrome. The following information was reported: CHILLS (non-serious) with onset Oct2022, outcome "unknown"; ARTHRALGIA (non-serious) with onset Oct2022, outcome "unknown", described as "Joint pain"; MYALGIA (non-serious) with onset Oct2022, outcome "unknown", described as "Muscle pain"; ANAPHYLACTIC REACTION (medically significant) with onset Oct2022, outcome "unknown", described as "anaphylaxis"; PYREXIA (non-serious) with onset Oct2022, outcome "unknown", described as "fever of 100"; VACCINATION SITE ERYTHEMA (non-serious) with onset Oct2022, outcome "unknown", described as "my right arm where the vaccine was given is rock hard bit red"; VACCINATION SITE INDURATION (non-serious), VACCINATION SITE PAIN (non-serious), VACCINATION SITE ECZEMA (non-serious) all with onset Oct2022, outcome "unknown" and all described as "right arm where the vaccine was given is rock hard bit red it has eczema, and it is quite painful"; FATIGUE (non-serious) with onset Oct2022, outcome "unknown", described as "terrible fatigue". The patient underwent the following laboratory tests and procedures: Body temperature: 100; Magnetic resonance imaging: Unknown Results. Therapeutic measures were taken as a result of anaphylactic reaction, pyrexia, vaccination site erythema, vaccination site induration, vaccination site pain, vaccination site eczema, chills, fatigue, arthralgia, myalgia.  Clinical course: Consumer stated, she was vaccinated last night, and she had a fever of 100 that could probably be higher except am taking those Aspirin and paracetamol (TYLENOL) (Further clarified as treatment) her right arm where the vaccine was given was rock hard bit red it had eczema, and it was quite painful, and she was also having terrible fatigue, Joint pain, Muscle pain, Chills etcetera like very much reaction and the reason she wanted to report it because she had mast cell activation syndrome so, actually she was having almost anaphylaxis from this and she knew her reaction was far more severe than the people but she felt somebody had them because (Incomplete sentence). She did not have that information, but cancer institute might. no, she did not have it her doctor office might. She had cancer and Ehlers-Danlos syndrome and mast cell activation syndrome she had several, she had Angiosarcoma on her pancreas it was the type of cancer that was very rare. Right now yes, as well as her inhaler as Cromolyn sodium her had mast cell activation syndrome, so she was taking bunch of antihistamine and mast cell stabilization product because she was having such a severe reaction, so she did not have anaphylaxis (as reported). Consumer stated, "It was less then 24 hrs. Since I was given the vaccine.".  The information on the batch/lot number for pneumococcal 20-val conj vac (dipht CRM197 protein) has been requested and will be submitted if and when received.