My quality of life has diminished after getting second shot; calf pain; left knee pain; wrist pain; Swollen arm and fingers; hand pain; Uncontrollable shaking; strong pain across chest; Right shoulder pain; upper body ache; Vomiting; left pain in arm; right pain in arm; This spontaneous case was reported by a consumer and describes the occurrence of PAIN IN EXTREMITY (calf pain), CHEST PAIN (strong pain across chest), TREMOR (Uncontrollable shaking), PERIPHERAL SWELLING (Swollen arm and fingers) and IMPAIRED QUALITY OF LIFE (My quality of life has diminished after getting second shot) in a 64-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 036c21a and 002C21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     No medical history was provided by the reporter.  Concomitant products included LEVOTHYROXINE, ALENDRONATE SODIUM (ALENDRONATE), CALCIUM and MULTIVITAMIN [VITAMINS NOS] for an unknown indication.   On 22-Apr-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 20-May-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. On 21-May-2021, the patient experienced PAIN IN EXTREMITY (right pain in arm). On 23-May-2021, the patient experienced PAIN IN EXTREMITY (left pain in arm). 23-May-2021, the patient experienced VOMITING (Vomiting). On 24-May-2021, the patient experienced CHEST PAIN (strong pain across chest). 24-May-2021, the patient experienced ARTHRALGIA (Right shoulder pain) and MYALGIA (upper body ache). On 25-May-2021, the patient experienced TREMOR (Uncontrollable shaking). On 29-May-2021, the patient experienced PERIPHERAL SWELLING (Swollen arm and fingers). 29-May-2021, the patient experienced PAIN IN EXTREMITY (hand pain) and ARTHRALGIA (wrist pain). On 05-Jun-2021, the patient experienced ARTHRALGIA (left knee pain). On 07-Jun-2021, the patient experienced PAIN IN EXTREMITY (calf pain). On an unknown date, the patient experienced IMPAIRED QUALITY OF LIFE (My quality of life has diminished after getting second shot). The patient was treated with IBUPROFEN (ADVIL [IBUPROFEN]) ongoing since an unknown date for Adverse event, at a dose of 1 dosage form and PARACETAMOL (TYLENOL) ongoing since an unknown date for Adverse event, at a dose of 1 dosage form. At the time of the report, PAIN IN EXTREMITY (calf pain), CHEST PAIN (strong pain across chest), TREMOR (Uncontrollable shaking), PERIPHERAL SWELLING (Swollen arm and fingers), IMPAIRED QUALITY OF LIFE (My quality of life has diminished after getting second shot), PAIN IN EXTREMITY (right pain in arm), PAIN IN EXTREMITY (left pain in arm), PAIN IN EXTREMITY (hand pain), ARTHRALGIA (Right shoulder pain), ARTHRALGIA (wrist pain), ARTHRALGIA (left knee pain), MYALGIA (upper body ache) and VOMITING (Vomiting) outcome was unknown.            Treatment medication: ice packs for swelling on arms, Medrol pack for joint pain   This case was linked to MOD21-115576, MOD21-115568, MOD21-117891, MOD21-108154 (Patient Link).   Most recent FOLLOW-UP information incorporated above includes: On 25-Jun-2021: Follow up received on 25 JUN 2021 and event was updated , email address was updated. On 02-Jul-2021: Follow up received on 02-Jul-2021. Follow up contains No new information