her mobility has improved/my health and movement were dramatically improved/my MS symptoms (like fatigue and trigeminal neuralgia) disappeared for several weeks; This is a spontaneous report from a contactable consumer (patient) received via medical information team and based on information received by Pfizer from BioNTech (manufacturer control number: 76522), license party for BNT162B2.   A 51-year-old female patient received the first dose of BNT162B2 (PFIZER-BIONTECH COVID-19 mRNA VACCINE) received on 21Mar2021 (lot number: EN6207) at dose 1, single; then second dose received on 11Apr2021 (lot number: ER8734) at dose 2, single; both at the age of 50-years-old via an unspecified route of administration in the arm for COVID-19 immunisation. Medical history included ongoing multiple sclerosis diagnosed from Oct1995, and ongoing physical therapy. The patient has no prior vaccinations within 4 weeks before Pfizer COVID vaccine vaccination. No family history relevant to the adverse events. The patient's concomitant medications were not reported. It was reported that on an unspecified date in 2021, after receiving both doses of the Pfizer COVID-19 vaccine, the patient's mobility improved and was able to do daily tasks more independently. The patient has a history of diagnosis of multiple sclerosis. Further reported that the patient had multiple sclerosis since Oct1995, was now protected from COVID, and that the COVID vaccine has improved her multiple sclerosis, it was a miracle. The patient can work in her home, and wash dishes. Previously, the patient was usually on a wheelchair. The patient was having the worst fatigue with her multiple sclerosis and that she couldn't speak to her husband or children. Now, the patient can sit on the floor and play with her daughter. The patient's fatigue due to multiple sclerosis was now so much better. The patient was asking how she can et the booster shot of the COVID vaccine. On 07Apr2021, the patient was able to wash the dishes. The patient was going to a physical therapist and they were amazed that the patient was getting better. In the physical therapy, they put weights on the patient's legs and would change it because the weights were too light. The patient's doctor stated that the patient was not the only one who said that they had this reaction. The patient's husband said that the patient was already better after the first dose. The patient was dancing, fighting with her husband, and washing the dishes after the first dose. It was reported that the events did not require emergency room visit and physician office visit. The patient stated that she read a news report that Pfizer developed a vaccine which cures multiple sclerosis in mice. The news report cited the work and findings that were published. The patient was diagnosed with multiple sclerosis in Oct1995. The patient received both doses of Pfizer-BioNTech COVID-19 vaccine, and on an unspecified date in 2021, the patient's health and movements dramatically improved, and the patient's multiple sclerosis symptoms (such as fatigue and trigeminal neuralgia) disappeared for several weeks. Outcome of the event was unknown.    Follow-up attempts are completed. No further information is expected.