Joints clicking; Hypermobile/lax joints - similar to EDS; Hypermobile/lax joints - similar to EDS; stretchy skin; Insomnia; Gait change; Numbness in foot; Progressive muscle atrophy; connective tissue/collagen issue; connective tissue/collagen issue; Head pressure; Floaters in eyes; Double vision; Light sensitivity (couldn't look at screen); Shortness of breath; Automatic nervous system disfunction; Bobble head sensation/weak neck; Brain fog; Fatigue PEM; Fatigue PEM; Low blood pressure; Exercise intolerance; New allergies to high histamine foods; Hand/foot pain; Irregular heartbeat; Inflammation; Low grade fever for weeks; GI issues / acid reflux; Dry mouth / eyes; Dry mouth / eyes; This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP). The reporter is the patient.  A 33-year-old female patient (not pregnant) received BNT162b2 (BNT162B2), on 20Jan2022 as dose 3 (booster), single (Lot number: EW0183) at the age of 33 years, in left arm for covid-19 immunisation. The patient's relevant medical history and concomitant medications were not reported. Vaccination history included: BNT162b2 (Dose Number: 1, Batch/Lot No: FJ5683, Location of injection: Arm Left), administration date: 06Jun2021, when the patient was 33-year-old, for Covid-19 immunization; BNT162b2 (Dose Number: 2, Batch/Lot No: EW0177, Location of injection: Arm Left), administration date: 16May2021, when the patient was 33-year-old, for Covid-19 immunization. The following information was reported: DRY MOUTH (non-serious), DRY EYE (non-serious) all with onset 03Feb2022, outcome "not recovered" and all described as "Dry mouth / eyes"; GASTROOESOPHAGEAL REFLUX DISEASE (non-serious) with onset 03Feb2022, outcome "not recovered", described as "GI issues / acid reflux"; PAIN IN EXTREMITY (non-serious) with onset 03Feb2022, outcome "not recovered", described as "Hand/foot pain"; INFLAMMATION (non-serious) with onset 03Feb2022, outcome "not recovered"; HEART RATE IRREGULAR (non-serious) with onset 03Feb2022, outcome "not recovered", described as "Irregular heartbeat"; PYREXIA (non-serious) with onset 03Feb2022, outcome "not recovered", described as "Low grade fever for weeks"; AUTONOMIC NERVOUS SYSTEM IMBALANCE (non-serious) with onset Apr2022, outcome "not recovered", described as "Automatic nervous system disfunction"; MUSCULOSKELETAL DISCOMFORT (non-serious) with onset Apr2022, outcome "not recovered", described as "Bobble head sensation/weak neck"; FEELING ABNORMAL (non-serious) with onset Apr2022, outcome "not recovered", described as "Brain fog"; DIPLOPIA (non-serious) with onset Apr2022, outcome "not recovered", described as "Double vision"; EXERCISE TOLERANCE DECREASED (non-serious) with onset Apr2022, outcome "not recovered", described as "Exercise intolerance"; FATIGUE (non-serious), MALAISE (non-serious) all with onset Apr2022, outcome "not recovered" and all described as "Fatigue PEM"; VITREOUS FLOATERS (non-serious) with onset Apr2022, outcome "not recovered", described as "Floaters in eyes"; HEAD DISCOMFORT (non-serious) with onset Apr2022, outcome "not recovered", described as "Head pressure"; PHOTOPHOBIA (non-serious) with onset Apr2022, outcome "not recovered", described as "Light sensitivity (couldn't look at screen)"; HYPOTENSION (non-serious) with onset Apr2022, outcome "not recovered", described as "Low blood pressure"; FOOD ALLERGY (non-serious) with onset Apr2022, outcome "not recovered", described as "New allergies to high histamine foods"; DYSPNOEA (non-serious) with onset Apr2022, outcome "not recovered", described as "Shortness of breath"; GAIT DISTURBANCE (non-serious) with onset Jun2022, outcome "not recovered", described as "Gait change"; JOINT LAXITY (non-serious), HYPERMOBILITY SYNDROME (non-serious) all with onset Jun2022, outcome "not recovered" and all described as "Hypermobile/lax joints - similar to EDS"; INSOMNIA (non-serious) with onset Jun2022, outcome "not recovered"; JOINT NOISE (non-serious) with onset Jun2022, outcome "not recovered", described as "Joints clicking"; HYPOAESTHESIA (non-serious) with onset Jun2022, outcome "not recovered", described as "Numbness in foot"; MUSCLE ATROPHY (non-serious) with onset Jun2022, outcome "not recovered", described as "Progressive muscle atrophy"; CONNECTIVE TISSUE DISORDER (non-serious), COLLAGEN DISORDER (non-serious) all with onset Jun2022, outcome "not recovered" and all described as "connective tissue/collagen issue"; SKIN DISORDER (non-serious) with onset Jun2022, outcome "not recovered", described as "stretchy skin". The events "hand/foot pain", "irregular heartbeat", "inflammation", "low grade fever for weeks", "gi issues / acid reflux", "dry mouth / eyes", "head pressure", "floaters in eyes", "double vision", "light sensitivity (couldn't look at screen)", "shortness of breath", "automatic nervous system disfunction", "bobble head sensation/weak neck", "brain fog", "fatigue pem", "low blood pressure", "exercise intolerance", "new allergies to high histamine foods", "joints clicking", "hypermobile/lax joints - similar to eds", "stretchy skin", "insomnia", "gait change", "numbness in foot", "progressive muscle atrophy" and "connective tissue/collagen issue" required physician office visit and emergency room visit. Relevant laboratory tests and procedures are available in the appropriate section. Therapeutic measures were not taken as a result of pain in extremity, heart rate irregular, inflammation, pyrexia, gastrooesophageal reflux disease, dry mouth, dry eye, head discomfort, vitreous floaters, diplopia, photophobia, dyspnoea, autonomic nervous system imbalance, musculoskeletal discomfort, feeling abnormal, fatigue, malaise, hypotension, exercise tolerance decreased, food allergy, joint noise, joint laxity, hypermobility syndrome, skin disorder, insomnia, gait disturbance, hypoaesthesia, muscle atrophy, connective tissue disorder, collagen disorder. Additional information: The patient had no other medical history; previously very healthy and active. The patient did not have COVID prior to vaccination. There were no other vaccines within four weeks. First wave of effects happened proportional to 2 weeks after booster shot and lasted from Feb2022 to Apr2022 which included: Hand/foot pain, irregular heartbeat, inflammation, low grade fever for weeks, GI issues / acid reflux, dry mouth / eyes. Second wave of symptoms occurring from Apr2022 to Jun2022 included: head pressure, floaters in eyes, double vision, light sensitivity (couldn't look at screen), shortness of breath, automatic nervous system disfunction, bobble head sensation/weak neck, brain fog, fatigue PEM, low blood pressure, exercise intolerance, new allergies to high histamine food. Then the last wave of symptoms started in Jun2022 and were currently still affecting the patient included: joints clicking, hypermobile/lax joint-similar to EDS, stretchy skin, insomnia, gait change, numbness in foot, progressive muscle atrophy, felt like connective tissue/collagen issue.  Follow-up (18Aug2022): Follow-up attempts are completed. No further information is expected.