Depression; hot flashes,Hot flushes unexplained by an endocrinologist; Psychological imbalance/not coping well/ withdrawing from people; increased fatigue; febrile norm 97 elevated to 101.2; Goiter,Goiter growth; Palpitations; Rash; Severe flushing; Brain fog; Loss of appetie,loss of appetite; Diarrhea; 1st dose 23Feb2021; 2nd dose 25Apr2021; Felt very weak; Turned pink; This spontaneous case was reported by a consumer and describes the occurrence of DEPRESSION (Depression), HOT FLUSH (hot flashes,Hot flushes unexplained by an endocrinologist), INAPPROPRIATE SCHEDULE OF PRODUCT ADMINISTRATION (1st dose 23Feb2021; 2nd dose 25Apr2021), ASTHENIA (Felt very weak) and SKIN DISCOLOURATION (Turned pink) in a 69-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 020B21A and 036A21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     Concurrent medical conditions included Asthma and Goitre since July 2021.   On 23-Feb-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 25-Apr-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 25-Apr-2021, the patient experienced INAPPROPRIATE SCHEDULE OF PRODUCT ADMINISTRATION (1st dose 23Feb2021; 2nd dose 25Apr2021), ASTHENIA (Felt very weak) and SKIN DISCOLOURATION (Turned pink). In June 2021, the patient experienced FLUSHING (Severe flushing), FEELING ABNORMAL (Brain fog), DECREASED APPETITE (Loss of appetie,loss of appetite), DIARRHOEA (Diarrhea), PALPITATIONS (Palpitations) and RASH (Rash). In July 2021, the patient experienced GOITRE (Goiter,Goiter growth). On an unknown date, the patient experienced DEPRESSION (Depression), HOT FLUSH (hot flashes,Hot flushes unexplained by an endocrinologist), EMOTIONAL DISTRESS (Psychological imbalance/not coping well/ withdrawing from people), FATIGUE (increased fatigue) and PYREXIA (febrile norm 97 elevated to 101.2). The patient was treated with PARACETAMOL (TYLENOL) for Fever, at an unspecified dose and frequency. On 25-Apr-2021, INAPPROPRIATE SCHEDULE OF PRODUCT ADMINISTRATION (1st dose 23Feb2021; 2nd dose 25Apr2021), ASTHENIA (Felt very weak) and SKIN DISCOLOURATION (Turned pink) had resolved. On 25-Jul-2021, DIARRHOEA (Diarrhea) had resolved. At the time of the report, DEPRESSION (Depression), HOT FLUSH (hot flashes,Hot flushes unexplained by an endocrinologist), EMOTIONAL DISTRESS (Psychological imbalance/not coping well/ withdrawing from people), FATIGUE (increased fatigue) and PYREXIA (febrile norm 97 elevated to 101.2) outcome was unknown and FLUSHING (Severe flushing), FEELING ABNORMAL (Brain fog), DECREASED APPETITE (Loss of appetie,loss of appetite), GOITRE (Goiter,Goiter growth), PALPITATIONS (Palpitations) and RASH (Rash) had not resolved.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On an unknown date, Stool analysis: no bacteria found (Negative) No bacteria found.         Patient already consulted with an endocrinologist who together with her primary doctor do not know what to do. Patient reported Hot flushes unexplained by an endocrinologist. No cancer detected. Goiter growth.  No concomitant medications were reported.   This case was linked to MOD-2021-270782 (Patient Link).   Most recent FOLLOW-UP information incorporated above includes: On 25-Oct-2021: Follow up received. Additional events were updated. Events and outcome of the events corrected from the initial SD. On 28-Oct-2021: Significant Follow up. Added event Goitre growth.