Affecting her health, mentally, and emotionally; Rash; Rash all over their face; Headache; Nose bleeds/ Nose bleed is ongoing; Left side of their face felt droopy; Face felt like it was on fire; Face was red; Itching; This spontaneous case was reported by a consumer and describes the occurrence of EPISTAXIS (Nose bleeds/ Nose bleed is ongoing), EMOTIONAL DISTRESS (Affecting her health, mentally, and emotionally), FACIAL PARALYSIS (Left side of their face felt droopy), BURNING SENSATION (Face felt like it was on fire) and ERYTHEMA (Face was red) in a 40-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch no. 006B21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     No medical history information was provided by the reporter.  Concomitant products included LANSOPRAZOLE (PREVACID), LEVOCETIRIZINE DIHYDROCHLORIDE (XYZAL), BUSPIRONE, ALPRAZOLAM (XANAX), ACYCLOVIR [ACICLOVIR] and MULTIVITAMINS [VITAMINS NOS] for an unknown indication.    On 23-Mar-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 23-Mar-2021, the patient experienced EPISTAXIS (Nose bleeds/ Nose bleed is ongoing), FACIAL PARALYSIS (Left side of their face felt droopy), BURNING SENSATION (Face felt like it was on fire), ERYTHEMA (Face was red), PRURITUS (Itching), RASH (Rash all over their face) and HEADACHE (Headache). On 02-Apr-2021, the patient experienced RASH (Rash). On an unknown date, the patient experienced EMOTIONAL DISTRESS (Affecting her health, mentally, and emotionally). The patient was treated with ACETYLSALICYLIC ACID, CAFFEINE, PARACETAMOL (EXCEDRIN [ACETYLSALICYLIC ACID;CAFFEINE;PARACETAMOL]) for Headache, at an unspecified dose and frequency and HYDROXYZINE (ATARAX [HYDROXYZINE]) for Itching, at an unspecified dose and frequency. On 25-Mar-2021, FACIAL PARALYSIS (Left side of their face felt droopy), BURNING SENSATION (Face felt like it was on fire), ERYTHEMA (Face was red), PRURITUS (Itching), RASH (Rash all over their face) and HEADACHE (Headache) had resolved. On 03-Apr-2021, RASH (Rash) had resolved. At the time of the report, EPISTAXIS (Nose bleeds/ Nose bleed is ongoing) had not resolved and EMOTIONAL DISTRESS (Affecting her health, mentally, and emotionally) outcome was unknown.        The action taken with mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown) was unknown.       The patient has gone to see their health care provider, an allergist, and an ears, nose, throat provider to help with the nose bleeds, which have never resolved. The patient has had blood work done, a CT scan, and nose cauterization. The results for the tests are not reported.  Other Concomitant medications included birth control.   Most recent FOLLOW-UP information incorporated above includes: On 05-Aug-2021: Follow-up receive and contains No new information, Consent for follow-up denied On 31-Aug-2021: Follow up received as non-significant information regarding event but initially it was submitted as non serious case instead of serious case.; Sender's Comments: Based on the current available information and temporal association between the use of the product and the start date of the events, a causal relationship cannot be excluded.