after second dose--it stopped her muscle tremors/improve her walking again as well as her energy levels/ Headaches and what she says as her head feels completely clear for the first time in months; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP).  A female patient received bnt162b2 (BNT162B2), administration date 30Aug2021 07:30 (Batch/Lot number: unknown) as dose 2, single for covid-19 immunisation. Relevant medical history included: "ALS", start date: Apr2021 (unspecified if ongoing). The patient's concomitant medications were not reported. Vaccination history included: Bnt162b2 (Dose 1), for COVID-19 immunization. The following information was reported: THERAPEUTIC RESPONSE UNEXPECTED (non-serious), outcome "unknown", described as "after second dose--it stopped her muscle tremors/improve her walking again as well as her energy levels/ Headaches and what she says as her head feels completely clear for the first time in months". Additional information: Caller proceeded to provide details from email, stating the emailer did mentioned Covid: "He was writing this on behalf of his girlfriend who had an incredible positive reaction to the Pfizer Covid vaccine. She was recently diagnosed with ALS in April: On, 30Aug 2021 she received the second dose of the vaccine and while it didn't correct her voice this time, it did dramatically improve her walking again as well as her energy levels. It also stopped her muscle tremors. Her headaches and what she says as her head feels completely clear for the first time in months. It was now 02Sep2021 and as of 10pm she was still feeling good. She got the second shot at 7:30am on the 30th. They would be very interested in talking to someone about this, with this dreadful disease, anything that can be done to cure or ease the pain and suffering would be a major leap. She was scheduled on 28Sep2021 for a clinical trial, where they would also tell the doctors about this." Caller stated this was the end of the email received today and he was unable to provide outcome of events stating he does not know person/patient and other dates were not provided. No further details provided. Unable to provide date, NDC, Lot, dose, or expiry for first Covid vaccine dose, it was not specify in email. Received the second dose on 30Aug2021 at 7:30am. Unable to provide the NDC, Lot, dose, or expiry. Caller unable to provide if any other vaccines given the same day or any problems with vaccines in past. Unable to provide the facility in which vaccines were given. No further details provided. History of all previous immunization with the Pfizer vaccine considered as suspect (or patient age at first and subsequent immunizations if dates of birth or immunizations are not available): Unknown. Did any AE(s) require a visit to: Emergency Room: Unknown. Physician Office: Unknown. Prior Vaccinations (within 4 weeks) If applicable, list any other vaccinations within four weeks prior to the first administration date of the suspect vaccine(s): Provide other relevant medical history including but not limited to these conditions: diagnosed allergies, compromised immune status, respiratory illness, genetic/chromosomal abnormalities, endocrine abnormalities (including diabetes) and obesity: recently diagnosed with ALS in Apr2021.  No follow-up attempts are possible; information about lot/batch number cannot be obtained. No further information is expected.