After developing great weakness after both Pfizer booster shots; fell; severe reactions to his 1st and 2nd booster; couldn't walk a straight line; BP dropped; could barely get up from the chair; hit his head; had a superficial cut; unitary infection; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP) from medical information team. The reporter is the patient.  An 83-year-old male patient received BNT162b2 (BNT162B2), on 16Oct2021 as dose 3 (booster), single (Lot number: FF2589) at the age of 83 years for covid-19 immunization. The patient's relevant medical history included: "heart trouble" (unspecified if ongoing); "Diabetes" (unspecified if ongoing). The patient took concomitant medications. Vaccination history included: BNT162b2 (DOSE 1 SINGLE NDC, LOT, EXP:  Unknown, Clarified that patient had 4 total doses Pfizer Covid-19 vaccine), administration date: 14Jan2021, when the patient was 82-year-old, for COVID-19 immunization, reaction(s): "sore arm"; BNT162b2 (DOSE 2 SINGLE NDC, LOT, EXP:  Unknown, Clarified that patient had 4 total doses Pfizer Covid-19 vaccine), administration date: 04Feb2021, when the patient was 82-year-old, for COVID-19 immunization, reaction(s): "sore arm". The following information was reported: BLOOD PRESSURE DECREASED (hospitalization) with onset Oct2021, outcome "unknown", described as "BP dropped"; LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (hospitalization) with onset Oct2021, outcome "unknown", described as "could barely get up from the chair"; GAIT DISTURBANCE (hospitalization) with onset Oct2021, outcome "unknown", described as "couldn't walk a straight line"; SKIN LACERATION (hospitalization) with onset Oct2021, outcome "unknown", described as "had a superficial cut"; HEADACHE (hospitalization) with onset Oct2021, outcome "unknown", described as "hit his head"; URINARY TRACT INFECTION (hospitalization) with onset Oct2021, outcome "unknown", described as "unitary infection"; ASTHENIA (hospitalization) with onset 17Oct2021, outcome "unknown", described as "After developing great weakness after both Pfizer booster shots"; FALL (hospitalization) with onset 17Oct2021, outcome "unknown", described as "fell"; IMMUNISATION REACTION (hospitalization) with onset 17Oct2021, outcome "unknown", described as "severe reactions to his 1st and 2nd booster". The patient was hospitalized for asthenia, fall, gait disturbance, blood pressure decreased, loss of personal independence in daily activities, headache, skin laceration, urinary tract infection, immunization reaction (start date: 17Oct2021, discharge date: 20Oct2021, hospitalization duration: 3 day(s)). The events "after developing great weakness after both pfizer booster shots", "fell", "couldn't walk a straight line", "bp dropped", "could barely get up from the chair", "hit his head", "had a superficial cut" and "severe reactions to his 1st and 2nd booster" required emergency room visit. The patient underwent the following laboratory tests and procedures: Blood pressure measurement: BP dropped; Weight: About 167, notes: Weight: About 167. Therapeutic measures were taken as a result of urinary tract infection.  Clinical course: Reporter stated that After developing great weakness after both Pfizer booster shots, was it likely that it would be the same with the current booster or are the ingredients different? Please advise. severe reaction, became extremely weak, fell down He had a rather severe reaction to the last 2 boosters of the Covid-19 vaccine. With the original 2 vaccines, the injections, really had nothing more than usual. They were all Pfizer. Had the usual sore arm and nothing else. With the last 2, he had a really severe reaction and became extremely weak. With the first one, he got up out of the chair and was so weak, when he started walking, went sideways and fell down, hit his head and had to go to the hospital. After the second booster, it was about the same. Didn't fall down but if he was sitting up, he would just fall over, he was so weak. Clarified that he did not go to hospital the second time and this reaction occurred after first and second booster of Covid vaccine. Did not have any real problems with first 2, original doses Covid vaccine. Had a little sore arm but not bad. Had got several medical conditions and was on gobs of medicine. AE(s) following prior vaccinations were None. No family medical history relevant to AE(s) relevant tests were none. Male patient and his wife called about the Pfizer COVID-19 Vaccine Bivalent booster and wanted to know if it is made with the same ingredients as the original Pfizer COVID-19 Vaccine. As per caller: Wife of the male patient took over the call. Caller stated that the patient has taken the Pfizer COVID-19 Vaccine for his primary series and 1st and 2nd booster doses. Patient was fine with the primary series. Patient wanted to get his 3rd booster but had severe reactions to his 1st and 2nd booster. Patient became very weak after his 1st booster. Patient could barely get up from the chair. Patient couldn't walk a straight line, fell, hit the table, and hit his head. Patient's BP dropped, so his wife called the squad to bring him to the hospital. Hospital was informed that the patient took the booster the day before. Patient's head was checked and had a superficial cut, but he did not need stitches. Patient was found to have UTI and was treated for it. Caller was told that it was hard to decide if it was prompted by the booster or by UTI. Patient was discharged 4 days later. During the patient's 2nd booster, when he sat on the side of the bed, he would fall over like he had no muscle control. Patient was very weak for about two days. Caller mentioned that they had spoken to the primary care doctor who told them to wait if anyone has any type of reaction with the Pfizer COVID-19 Vaccine Bivalent Booster. Caller stated that they were wondering if there were any changes other than the variants with the new bivalent booster to encourage them to take the booster. This came to Pfizer Medical Information as a webform from Pfizer-sponsored program. This CEP was correct  Follow-up attempts are completed. No further information is expected.; Sender's Comments: Linked Report(s) : US-PFIZER INC-202201240323 Same patient, drug, and event separated in time;US-PFIZER INC-202201240542 similar report from same reporter;US-PFIZER INC-202201240528 similar report from same reporter;