some swelling in both knees; I can't do my normal activities with my kids, I can't do physical activities.; Arm swelling; EXTREME pain in both of my knees/ Bilateral knee pain; This spontaneous case was reported by a consumer and describes the occurrence of JOINT SWELLING (some swelling in both knees), LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (I can't do my normal activities with my kids, I can't do physical activities.), PERIPHERAL SWELLING (Arm swelling) and ARTHRALGIA (EXTREME pain in both of my knees/ Bilateral knee pain) in a 32-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 022C21A and 039B21A) for COVID-19 vaccination.     The patient's past medical history included Caesarean section in 2017 and Cholecystectomy in 2003. Concurrent medical conditions included Drug allergy, Food allergy, Rhinitis, Chronic back pain, Degenerative disc disease, Depression, Fibromyalgia, Generalized anxiety disorder, Headache, Insomnia, Lumbar disc degeneration, Lumbar disc herniation, Lupus syndrome, Migraine headache, Major depression, Morbid obesity, Spondylolisthesis (Lumbar region), Tobacco user (Smoking tobacco use of 4 or less cigarettes per day in last 30 days.) and Irritable bowel syndrome. Concomitant products included SERTRALINE HYDROCHLORIDE (ZOLOFT) for Anxiety and Depression, TRAZODONE and DIPHENHYDRAMINE HYDROCHLORIDE (BENADRYL N) for Insomnia, IRON for Iron supplementation, BUPROPION HYDROCHLORIDE (WELLBUTRIN XL) for Major depression, PARACETAMOL (TYLENOL) for Pain and Insomnia, VITAMIN B COMPLEX for Vitamin B2 supplementation, LEVONORGESTREL (MIRENA) for an unknown indication.   On 14-Apr-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 13-May-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. On 05-Jun-2021, the patient experienced ARTHRALGIA (EXTREME pain in both of my knees/ Bilateral knee pain). On an unknown date, the patient experienced JOINT SWELLING (some swelling in both knees), LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (I can't do my normal activities with my kids, I can't do physical activities.) and PERIPHERAL SWELLING (Arm swelling). The patient was treated with AMOXICILLIN SODIUM, CLAVULANATE POTASSIUM (AUGMENTINE [AMOXICILLIN SODIUM;CLAVULANATE POTASSIUM]) (oral) for Sinus infection, at a dose of 875 milligram every twelve hours; METHYLPREDNISOLONE ACETATE (MEDROL [METHYLPREDNISOLONE ACETATE]) (oral) for Sinus infection, at a dose of 4 milligram once a day and IBUPROFEN ongoing since an unknown date for Knee pain, at an unspecified dose and frequency. At the time of the report, JOINT SWELLING (some swelling in both knees), LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (I can't do my normal activities with my kids, I can't do physical activities.) and PERIPHERAL SWELLING (Arm swelling) outcome was unknown and ARTHRALGIA (EXTREME pain in both of my knees/ Bilateral knee pain) had not resolved.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On an unknown date, Blood pressure measurement: 134/86 (High) 134/86. On an unknown date, Body temperature: 36.1 (normal) 36.1 degree Celsius. On an unknown date, Heart rate: 67 (normal) 67. On an unknown date, Oxygen saturation: 97 (normal) 97% SpO2.     For mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular), the reporter considered ARTHRALGIA (EXTREME pain in both of my knees/ Bilateral knee pain) to be possibly related. No further causality assessments were provided for JOINT SWELLING (some swelling in both knees), LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (I can't do my normal activities with my kids, I can't do physical activities.) and PERIPHERAL SWELLING (Arm swelling).    Previous medical surgery included Kidney stent(2014), Abscess reconstruction surgery.   Most recent FOLLOW-UP information incorporated above includes: On 04-Aug-2021: Follow up received include significant information as: patient demographics (height, weight, race and ethnic group), relevant history (current condition,surgery procedures, allergies), Laboratory investigations (X-ray), batch number details of 1st and 2nd dose, treatment medication were added. Outcome of events updated. Concomitant and treatment medicines were added.