Whole left side (top half of her butt to the hip) swelled up like she was having back problems again.; Whole left side (top half of her butt to the hip) swelled up like she was having back problems again.; Degenerative edema; She is hurting, she is in pain; This spontaneous case was reported by a consumer and describes the occurrence of JOINT SWELLING (Whole left side (top half of her butt to the hip) swelled up like she was having back problems again.), SWELLING (Whole left side (top half of her butt to the hip) swelled up like she was having back problems again.), BONE MARROW OEDEMA (Degenerative edema) and PAIN (She is hurting, she is in pain) in a 53-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch no. 016C21A) for COVID-19 vaccination.     The patient's past medical history included Surgery (Has had 3 surgeries this year and she has more surgeries to go (one surgery will be because of this shot)). Concurrent medical conditions included COPD and Degenerative disc disease.  On 21-Jun-2021, the patient received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On an unknown date, the patient experienced JOINT SWELLING (Whole left side (top half of her butt to the hip) swelled up like she was having back problems again.) (seriousness criterion medically significant), SWELLING (Whole left side (top half of her butt to the hip) swelled up like she was having back problems again.) (seriousness criterion medically significant), BONE MARROW OEDEMA (Degenerative edema) (seriousness criterion medically significant) and PAIN (She is hurting, she is in pain) (seriousness criterion medically significant). At the time of the report, JOINT SWELLING (Whole left side (top half of her butt to the hip) swelled up like she was having back problems again.), SWELLING (Whole left side (top half of her butt to the hip) swelled up like she was having back problems again.), BONE MARROW OEDEMA (Degenerative edema) and PAIN (She is hurting, she is in pain) outcome was unknown.      No concomitant medication provided.  No treatment information mentioned.  It was reported that the patient had many other comorbidities at baseline.  After second shot, patients whole left side swelled up. She has gone through 3 surgeries already and more to come. One more would be due to the shot she mentions. Has degenerative disc disease and claims to have degenerative edema now. Agent who handled call reported patient laughed hysterically during disclaimer and is rude and constantly interrupts and curses.   This case was linked to MOD-2022-452844 (Patient Link).; Sender's Comments: This case concerns a 53-year-old, female patient with relevant medical history degenerative disc disease and three surgeries in the past, who experienced the unexpected serious events of Joint Swelling, Swelling, Bone marrow edema, and Pain. The events occurred at unspecified interval after the second dose of mRNA-1273 (Moderna covid-19 vaccine). The rechallenge was not applicable as events occurred after second dose. This patient's underlying medical history remains a contributory factor. The benefit-risk relationship of mRNA-1273 (Moderna covid-19 vaccine) is not affected by this report.