throat tightness; a rash on the chest; headache; tiredness; Allergic reaction; Cough; A tightening feeling around the neck; common very painful arm reactions; This case was received via an unknown source (no reference has been entered for a health authority or license partner) on 21-Jan-2021 and was forwarded to Moderna on 28-Jan-2021.    This spontaneous case was reported by a physician and describes the occurrence of HYPERSENSITIVITY (Allergic reaction), COUGH (Cough), MUSCLE TIGHTNESS (A tightening feeling around the neck), PAIN IN EXTREMITY (common very painful arm reactions) and THROAT TIGHTNESS (throat tightness) in a 67-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch no. 011L20A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     The patient's past medical history included Anaphylactic reaction (When she received her pertussis booster last year, she had a beginning of an anaphylactic reaction where she couldn't breathe and experienced a tightening of the throat. She took a steroid and Benadryl at that time.). Previously administered products included for an unreported indication: BENADRYL [DIPHENHYDRAMINE HYDROCHLORIDE]. Concurrent medical conditions included Mercury sensitivity, Environmental allergy and Allergy to metals (Tin allergy).    On 19-Jan-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 19-Jan-2021, the patient experienced HYPERSENSITIVITY (Allergic reaction), COUGH (Cough), MUSCLE TIGHTNESS (A tightening feeling around the neck), PAIN IN EXTREMITY (common very painful arm reactions), HEADACHE (headache) and FATIGUE (tiredness). On 21-Jan-2021, the patient experienced THROAT TIGHTNESS (throat tightness) and RASH (a rash on the chest). The patient was treated with DIPHENHYDRAMINE HYDROCHLORIDE (BENADRYL [DIPHENHYDRAMINE HYDROCHLORIDE]) ongoing since an unknown date for Allergic reaction, at an unspecified dose and frequency and FAMOTIDINE (PEPCID [FAMOTIDINE]) ongoing since an unknown date for Rash and Throat tightness, at an unspecified dose and frequency. At the time of the report, HYPERSENSITIVITY (Allergic reaction), COUGH (Cough), MUSCLE TIGHTNESS (A tightening feeling around the neck), PAIN IN EXTREMITY (common very painful arm reactions), THROAT TIGHTNESS (throat tightness), RASH (a rash on the chest), HEADACHE (headache) and FATIGUE (tiredness) outcome was unknown. Not Provided      The action taken with mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) was unknown.   For mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular), the reporter did not provide any causality assessments.   The patient received unspecified steroids for her allergies. Reportedly, the patient was premedicated half an hour before receiving the vaccine by taking a Benadryl. 2 minutes after the vaccination, she had a cough and a tightening feeling around the neck and used the inhaler she had. She sat there for 45 minutes before returning home where she experienced the common very painful arm reactions, headache, and tiredness. She continued with the Benadryl and inhaler whenever she thought she needed it and stopped taking both on the 3rd day. She did take her regular medications for allergies. That same night she had a rash on the chest, throat tightness, and called the ER who recommended Pepcid. She used Benadryl, an unspecified inhaler, and Pepcid.       Most recent FOLLOW-UP information incorporated above includes: On 28-Jan-2021: Reporter information was updated. Patient details was reported. Events was reported. On 08-Jun-2021: Follow up received on 08JUN2021. No new information was reported.