protein levels in her urine were high. For this reason she was referred to the nephrologist who diagnosed her with Ig nephropathy/wife was loosing 300% more protein than normal people; This spontaneous case was reported by a patient family member or friend (subsequently medically confirmed) and describes the occurrence of IGA NEPHROPATHY (protein levels in her urine were high. For this reason she was referred to the nephrologist who diagnosed her with Ig nephropathy/wife was loosing 300% more protein than normal people) in a 37-year-old female patient who received mRNA-1273 BIVALENT .222 (MODERNA COVID-19 VACCINE, BIVALENT (ORIGINAL AND OMICRON BA.4/BA.5)) for COVID-19 prophylaxis.     Concurrent medical conditions included High cholesterol.   On an unknown date, the patient received dose of mRNA-1273 BIVALENT .222 (MODERNA COVID-19 VACCINE, BIVALENT (ORIGINAL AND OMICRON BA.4/BA.5)) (unknown route) 1 dosage form. On an unknown date, received dose of mRNA-1273 BIVALENT .222 (MODERNA COVID-19 VACCINE, BIVALENT (ORIGINAL AND OMICRON BA.4/BA.5)) (unknown route) dosage was changed to 1 dosage form. On an unknown date, the patient experienced IGA NEPHROPATHY (protein levels in her urine were high. For this reason she was referred to the nephrologist who diagnosed her with Ig nephropathy/wife was loosing 300% more protein than normal people) (seriousness criterion medically significant). At the time of the report, IGA NEPHROPATHY (protein levels in her urine were high. For this reason she was referred to the nephrologist who diagnosed her with Ig nephropathy/wife was loosing 300% more protein than normal people) had not resolved.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On an unknown date, Protein urine: protein levels in her urine were high..     For mRNA-1273 BIVALENT .222 (MODERNA COVID-19 VACCINE, BIVALENT (ORIGINAL AND OMICRON BA.4/BA.5)) (Unknown), the reporter did not provide any causality assessments.   No concomitant products reported.  It was unknown if patient received any other vaccines in the 4 weeks prior to COVID-19 vaccine.  Caller was contacting on behalf of his wife. He stated that his wife received 2 doses of the Moderna Covid 19 Vaccine and after that they did a routine check up exam and the protein levels in her urine were high. For that reason she was referred to the nephrologist who diagnosed her with Ig nephropathy . He said that his wife was loosing 300% more protein than normal people.  No treatment products reported.  Company Comment This spontaneous case concerns an 37-years-old female patient, with medical history of High cholesterol who experienced the seriousness criterion medically significant unexpected event of IgA nephropathy in the context of a  dose of  mRNA- 1273 bivalent vaccine. Previously, on unknown date, the patient received another dose of mRNA- 1273 bivalent vaccine. As her protein levels in urine were high, she was referred to a nephrologist who made the diagnosis. The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report. Events seriousness was assessed based on medical judgement.   Reporter did not allow further contact   Most recent FOLLOW-UP information incorporated above includes: On 25-Jan-2023: Follow up received wherein the patient demographics and narrative updated.