O2 level gets a low as 86%; Clammy; lungs feel like they are trying to fill with phlegm and is coughing up; pulse rate gets up to like 110; Extraordinary Fatigue; Chills; headache in the very top of her head; This is a spontaneous report from a contactable Consumer (the patient, reported herself). This 65-year-old female patient received second dose of BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE, Solution for injection, LOT number: EN6205 and expiration date was not provided), via an unspecified route of administration, in left arm on 27Feb2021 at 11:00 AM (at the age of 65-year-old) as single dose for COVID-19 immunization. The patient's medical history included ongoing cancer, metastatic thyroid cancer, metastatic thyroid cancer in her lungs and COVID-19 in Nov2020. Concomitant medication included ongoing lenvatinib mesylate (LENVIMA) 10mg once a day by mouth (LOT number: 1265572, expiry date: Feb2024) for cancer started on an unspecified date in Jul2020. The Lenvima causes headaches and stated that she can't explain it, but it makes her feel like her head is hollow. She said that what she had now was not a Lenvima headache, it was different. She said that they are typically in her sinus area or the back of her head. This headache is in the very top of her head. The patient historical vaccine included the first dose of BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE, Solution for injection, LOT number EL9264 and expiry date was not provided), via an unspecified route of administration in left arm on 29Jan2021 (at the age of 65-year-old) as single dose for COVID-19 immunization. With her first Covid shot, her left arm hurt and was warm to the touch for about a week. The patient experienced Chills (12-15 hours after she received the second dose of the vaccine) and headache in the very top of her head at night on 27Feb2021; lungs feel like they are trying to fill with phlegm and is coughing up, pulse rate gets up to like 110 and extraordinary Fatigue on 28Feb2021; O2 level gets a low as 86 % and Clammy on 01Mar2021. Patient reported that she got her second dose of the COVID-19 Vaccine on 27Feb2021 and she thought she had a reaction. She had other health issues that cause similar effects with some of the medications she took and clarified that she was also taking Lenvima. She was experiencing chills but has no fever. Her lungs feel like they are trying to fill with phlegm and her O2 level gets a low as 86 percentage. She had a pulse oximeter. This was the lowest it has been. She had metastatic thyroid cancer in her lungs. She stated that it is rare, and it was working on her slowly. Since the shot, she was getting more phlegm in her chest and lungs that she is coughing up. She said that the phlegm was clear. Her pulse rate gets up to like 110. It was back down to heh 80's before she called. The cancer drug, Lenvima, she was taking caused high blood pressure and high pulse. BP was 134/76 on 01Mar2021. Patient reported that she had an appointment with the oncologist tomorrow and she had to cancel it because she does not think she can make the trip she feels so terrible. Patient said that she is going to call her doctor after this. She had COVID in Nov2020 and it she did not have a fever but had extraordinary fatigue and stated that she has that now too. She said that she walked to her car and back and she was fatigued. she said that she took her oxygen level, and it was 94 percentage and pulse rate was 56. This time her arm doesn't hurt at all, but she has all of this other stuff going on. Patient reported that she also has a serious headache and Tylenol (Lot number: 0HV1335 and expiry: May2022) is not touching it. Tylenol UPC not available. The patient underwent lab tests and procedures which included blood pressure measurement was 134/76 on 01Mar2021, heart rate measurement was 110 (pulse rate gets up to like 110) on 28Feb2021 and was 56 on 01Mar2021, oxygen saturation measurement was 86 percentage (O2 level gets a low as 86percentage) and was 94 percentage on 01Mar2021, COVID-19/SARS-CoV-2 test positive on an unspecified date in Nov2020. Patient did not require a visit to emergency room and physician office for events. The patient did not receive any other vaccines within 4 weeks prior to the COVID vaccine. The outcome of all events was not recovered.  No follow-up attempts are possible. No further information is expected