quite red; knot on her arm started to shrink; it started to itch/ it was itching her/ arm is itching; It was hot to touch; a large knot on her arm; This is a spontaneous report from a contactable consumer (Patient). A 62-year-old female consumer received bnt162b2 (BNT162B2, Formulation: Solution for injection, Batch/Lot number: EN6204, Expiry date: 30Jun2021) dose 2, Via an unspecified route of administration, administered in left arm on 12Mar2021 at 10:20 as a single dose for (at the age of 62 year) COVID-19 immunisation. Medical history includes high blood pressure, underactive thyroid, and hypothyroidism from unknown start date and unknown if ongoing. Concomitant medication includes ongoing levothyroxine sodium (EUTHYROX) 112ug one tablet orally every morning for underactive thyroid, hypothyroidism over 20 years ago, Ongoing benazepril (BENAZEPRIL) 20 mg tablet orally started taking over 20 years ago and chlorthalidone (CHLORTHALIDONE) 25 mg tablet, started taking about 12 years both taken for high blood pressure start date and stop dates were not reported. Family Medical History Relevant to AE(s): On her maternal and paternal side, both parents had cancer. Her dad was in his seventies and her mom was in her forties. She does not know if this is relevant to her having a reaction on her arm. She has a thyroid condition and there is history of it on in her family on her paternal side, her dad and his mother have it. On her mother's side, history of geriatric diabetes, her aunt and mother's aunt had it. Before taking chlorthalidone, she originally took another water pill but it gave her leg cramps. Her doctor switched her from chlorthalizine to chlorthalidone. Clarified that the medication that gave her leg cramps was chlorthalizine. She was taking chlorthalizine 25mg once a day orally. She started taking chlorthalizine over 30 years ago for high blood pressure. Initially they treated her high blood pressure with a diuretic, but whenever that stopped working, they prescribed her benazepril. Clarified that the diuretic that stopped working was chlorthalizine. Historical vaccine includes bnt162b2 (BNT162B2, Formulation: Solution for injection, Batch/Lot number: EN6001, Expiry date: 30Jun2021) dose 1, Via an unspecified route of administration, administered in left arm on 12Mar2021 10:00AM as a single dose for (at the age of 62 year) COVID-19 immunisation. Within 24 hours of vaccination on 13Mar2021, the knot developed. A large knot on her arm. The knot was pretty good sized. It was hot to touch and also quite red. It remained unchanged until 17Mar2021. Her arm was hot to touch from 13Mar2021 to 16Mar2021. Then the knot was not hot, it was just warm and began to get smaller. As of today, the knot is still there, and it is probably about the size of a quarter. Whenever the knot on her arm started to shrink, it started to itch. It does not itch all of the time on 18Mar2021. The first day or so it was itching her nonstop. Her arm is itching now, and it made her think of it. Patient did not require to visit Emergency Room and Physician Office for the adverse event. Outcome of the event It was hot to touch was resolved on 16Mar2021 while for other events it was recovering and remained unknown for quite red.  No follow-up attempts are possible. No further information is expected.