very very itchy.; inflamed; these isolated spots on your right and your left elbow and one side of my face and my neck, so it was isolated, it was not a rash but so itchy and red and inflamed; big red blotch that was very itchy; I was going crazy; didn't sleep; My asthma has been worse; hive like hard bumps around elbow of same arm, as well as near ear of right side.; This is a spontaneous report from a contactable consumer (patient). A 77-year-old non-pregnant female patient received second dose of bnt162b2 (PFIZER-BIONTECH COVID-19 VACCINE, Solution for injection, Lot Number: EM6198) via an unspecified route of administration on 02Mar2021 (at the age of 77-year-old) as dose 2, single for COVID-19 immunization. Medical history included years ago penicillin allergy but have had since, bug bites allergy, allergic to mosquito bites and to insect bites, asthma, minor arthritis/spine, acid Reflux, high cholesterol. Concomitant medication(s) included atorvastatin calcium (STATIN), folic acid and multi-vitamin, vi taken for an unspecified indication in two weeks. The patient previously received first dose of bnt162b2 (PFIZER-BIONTECH COVID-19 VACCINE, Solution for injection) administration on right arm on 09Feb2021 (at the age of 77-year-old) as dose 1 single for Covid-19 immunization and experienced similar event with 2nd dose along with large blister. The patient did not receive any other vaccine in four weeks. Prior to vaccination, the patient was not diagnosed with COVID-19. Post vaccination, the patient had not been tested for COVID-19. On an unspecified date in Mar2021, the patient experienced similar events happened again after 2nd vaccine 02Mar2021 in same spots, no big blister just both elbows and neck, very very itchy as well as hive like hard bumps around elbow of same arm, as well as hive like bump near ear of right side. Followed by very itchy bumps on left arm at elbow site. Patient informed that after the 2nd shot it affected 2 elbows and the neck but no blister (same as the first but the first had the giant blister) and had gone to 2 physicians who didn't know what it was or if it may be an allergic reaction no one had identified it. Patient thought it was bug bites (allergic to mosquito bites and allergic to insect bites). It was so inflamed for a month patient was going crazy and doctor gave prednisone and Zyrtec. The 3rd person, patient spoke with thinks it's covid arm. No one can tell her what it was. Patient been to a dermatologist and internal doctor. Thinks it's the reaction to the covid vaccine. The problem with the reaction was when it's so inflamed. It feels like she got mosquito bite (like when she get a reaction) and didn't sleep the whole night. The doctor said, "I can't tell if it's a bug bite because it's so inflamed." Patient's asthma has been worse. It's horrible to have this. Thinking patient had bed bugs, it's been driving her crazy for a month. Patient informed that it's not just some itchiness, at first sight she thought she had insect bites. It happened in two locations under the right side of my neck which is like a big red blotch that was very itchy at the same time on my right arm and so the second time it happen it was not that bad, just in these isolated spots on right and left elbow and one side of face and neck, so it was isolated, it was not a rash, it was like an allergic reaction to mosquito bite but so itchy and red and inflamed. The doctor gave the patient antihistamine and now taking prednisone. Patient also asked about tests available to see if she had an allergic reaction to the pfizer vaccine. If the vaccine had histamine or would people who had allergies to bug bites have allergies to the Pfizer vaccine. The outcome of events hive like hard bumps around elbow of same arm, as well as hive like bump near ear of right side and very very itchy was recovering and rest all events was unknown. No follow-up attempts are possible. No further information is expected.