Hashimoto's disease; Histamine intolerances; Whenever the caller ingests food the histamine levels in her body become elevated; She can't eat that's going to make her fall asleep; She can't eat that's going to make her fall asleep/caller either falls asleep on the spot, including upright; Didn't feel perfect after the first dose/started to feel worse as time went on; She was so exhausted; Caller feels so poorly that she doesn't do anything except sit as a blob; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP). The reporter is the patient.  A 56-year-old female patient received BNT162b2 (BNT162B2), on 25Mar2021 as dose 1, single (Lot number: ER8732) at the age of 56 years for covid-19 immunisation. The patient's relevant medical history included: "Slight asthma" (unspecified if ongoing), notes: Slight asthma. Concomitant medication(s) included: FLONASE [FLUTICASONE PROPIONATE]; SINGULAIR; OMEPRAZOLE. Past drug history included: Antihistamines, notes: History: The caller took antihistamines which she takes ever day. The following information was reported: LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (non-serious) with onset 2021, outcome "unknown", described as "Caller feels so poorly that she doesn't do anything except sit as a blob"; FEELING ABNORMAL (non-serious) with onset 2021, outcome "unknown", described as "Didn't feel perfect after the first dose/started to feel worse as time went on"; AUTOIMMUNE THYROIDITIS (medically significant) with onset 2021, outcome "unknown", described as "Hashimoto's disease"; HISTAMINE INTOLERANCE (non-serious) with onset 2021, outcome "unknown", described as "Histamine intolerances"; FEEDING DISORDER (non-serious) with onset 2021, outcome "unknown", described as "She can't eat that's going to make her fall asleep"; SOMNOLENCE (non-serious) with onset 2021, outcome "unknown", described as "She can't eat that's going to make her fall asleep/caller either falls asleep on the spot, including upright"; FATIGUE (non-serious) with onset 2021, outcome "unknown", described as "She was so exhausted"; HISTAMINE LEVEL INCREASED (non-serious) with onset 2021, outcome "unknown", described as "Whenever the caller ingests food the histamine levels in her body become elevated". The event "histamine intolerances" required physician office visit. The patient underwent the following laboratory tests and procedures: Blood test: (2021) Elevated histamines, notes: Caller ingests food the histamine levels in her body become elevated. Therapeutic measures were taken as a result of histamine intolerance.   Clinical course: The caller had both of the initial Pfizer Covid vaccines and has had a major issues with histamine intolerances. The caller wanted to know if there has been any research on high histamines after the Covid vaccines. The caller has seen more doctors, both eastern and western, and taken more medications than she wants to. No one has been able to identify the caller's problem and it started 10 days after the vaccine. This could have been an underlying condition triggered by the vaccine or it could be coincidental. No one can find the root cause for what the caller's problem is. The caller's physician has 2 other patients with the same exact issues as the caller. The caller's doctor got feedback stating they had patients like this as well. But the doctors have not gotten any feedback on what has helped the other patients. Further stated that whenever the caller ingests food the histamine levels in her body become elevated. Any food high in histamine or are histamine liberators add to the problem and make the histamine levels rise to the point where the caller either falls asleep on the spot, including upright. Or the caller feels so poorly that she doesn't do anything except sit as a blob. The first day that the caller noticed this was the strongest was last year, 2021. Since it started the caller identifies approximately 8 things she can eat without causing a major disruption to her day. The caller works full time so she can't eat that's going to make her fall asleep. The caller has a strict schedule on a small breakfast and a small bite to eat this time and it keeps her blood sugar high enough without a high level of histamines. The caller has eaten the same 8 things for the last 8 months so she can keep her job. The caller didn't feel perfect after the first dose at the beginning. The caller started to feel worse as time went on. On Easter that's when it hit home for the caller, on 04Apr2021. The caller was really dragging. The caller was trying to walk to her brother's house and she was so exhausted which has to be 2000 feet away she wished she brought her Jeep. The caller became exhausted at that point thinking that's what the vaccines do. Then slowly it started to get worse and worse and food started becoming an issue. The day before Easter last year is the last time the caller ate a normal meal.   Patient received Second Dose on 15Apr2021 (lot ER8731) and third dose on 05Jan2022 (lot FL3209).  Follow-up attempts are completed. No further information is expected.