Her IgG was 3050/It had been climbing; This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP) from medical information team. The reporter is the patient.  A 79-year-old female patient received BNT162b2 (BNT162B2), on 27Jun2022 as dose 4 (booster), single (Lot number: FM0173) at the age of 78 years for covid-19 immunisation. The patient's relevant medical history included: "cancer" (unspecified if ongoing), notes: My cancer blood that pretty much takes me into normal range; "5 invasive heart procedures" (not ongoing); "4 strokes" (unspecified if ongoing); "4 different kinds of cancer" (unspecified if ongoing); "knee replacements" (not ongoing); "Myeloma" (unspecified if ongoing), notes: smoldering stage; "Polio", start date: 1951 (unspecified if ongoing) ; "totally paralysed" (unspecified if ongoing), notes: She has no residual paralysis except for the little bit she didn't recover from in the 1950s; "lost capability to breath" (unspecified if ongoing); "she even had to be revived" (unspecified if ongoing); "she was in iron lung" (unspecified if ongoing). There were no concomitant medications. Vaccination history included: BNT162b2 (DOSE 1, SINGLE , Batch\lot number: EL9264, at (withheld)), administration date: 29Jan2021, for COVID-19 immunisation, reaction(s): "Her numbers were climbing/reported them going down after her first vaccines"; BNT162b2 (DOSE 2, SINGLE , Batch\lot number: EN6198), administration date: 04Mar2021, for COVID-19 Immunization; BNT162b2 (DOSE 3 (BOOSTER), SINGLE , Batch\lot number: FE3592), administration date: 26Oct2021, for COVID-19 Immunization, reaction(s): "She has cancer and her readings are better". The following information was reported: THERAPEUTIC RESPONSE UNEXPECTED (non-serious), outcome "unknown", described as "Her IgG was 3050/It had been climbing". Relevant laboratory tests and procedures are available in the appropriate section.  Additional information: 79-year-old female stated, "About a year and a half ago, she had an hour long conversation with a nurse from Pfizer (withheld) regarding if it was possible if we were doing any clinical trials that had to do with the COVID vaccine reducing or improving cancer blood number results. She was supposed to get a call back and she never got a call. she let it go, however, she just had 2 eye shocking results with my cancer blood that pretty much takes her into normal range. The only thing that she can figure out is that she had her final booster. She called in originally because there was some kind of decline. She was wanting to see if she could now talk to someone in the area of clinical trials or research to follow-up. The numbers are significant. And she just could not believe they would be interested. She had the 3 shots, and then she had 1 booster. If it is true if this would have an affect." Reference number: #.Agency: Warm-transferred to (name withheld) Agency: #, Reportum: #. Duplicate AE e-transmitted. Response: Told caller we don't have a direct access line to speak to a researcher, however, told her there is the Clinical Trials Customer Service line which may provide information about clinical trials.Told caller no information found on the Agency regarding cancer benefits after receiving the vaccine and told caller Pfizer takes these reports very seriously. Told caller we are required to document and report any events whether positive or negative and take it very seriously in capturing these events. Offered to warm-transfer to safety to further report event. Warm transfer from (name withheld) Pfizer medical information: (withheld) Product: Pfizer COVID vaccine Bivalent for 12 years of age and older. About a year and a half of ago, she spoke with (name withheld) in this department. Reference: # After she received the vaccine, her cancer numbers started getting better. She was diagnosed with Myeloma and was just in the smoldering stage. She was not to the point of being treated. They had been monitoring her since 11Sep2020. Her numbers were climbing. She reported them going down after her first vaccines. Her first blood draw was 14Nov2022. When she first called in she was interested in convalescent therapy. She wanted to know if anyone had interest in her blood. She was in an Iron lung. She even had to be revived. She was totally paralyzed, and she lost capability to breath. She has been through a lot of critical health issues, but she was still her alive and kicking. She just hoped she could help others with her information.  No follow-up attempts are possible. No further information is expected.; Sender's Comments: Linked Report(s) : US-PFIZER INC-202101689707 same reporter/patient/vaccine, different dose(3)/similiar event;US-PFIZER INC-202300102500 same reporter/patient/vaccine, different dose(5)/similiar event;US-PFIZER INC-202300103094 same reporter/patient/vaccine, different dose(1)/similiar event;