UNUSUAL SOUNDS FROM LEFT LUNG BOTTOM; IRRITATED LUNGS AND BLEEDING; SEPSIS; COUGHING UP BLOOD AND PHLEGM; FEVER; DRY COUGHING; This spontaneous report received from a patient concerned a patient of unspecified age and sex. The patient's weight, height, and medical history were not reported. The patient received covid-19 vaccine ad26.cov2.s (suspension for injection, route of admin not reported, batch number: 1805029, and expiry: 25-MAY-2021) dose was not reported, administered on 27-MAR-2021 for prophylactic vaccination. No concomitant medications were reported.  On 27-MAR-2021 Patient temperature was 102.5-103 under arm, 103.5-104 orally. The temperature stayed that way for four days. Four days later Patient started dry coughing. Patient went to the clinic, patient's doctor listened to patient lungs, and did an x-ray. Patient's doctor said the x-ray is clear, however, patient's doctor hears an unusual sound from the bottom of patient left lung. Patient's doctor said she has been practicing for 15 years, and there are usual sounds that she is used to hear when listening to people's lungs. However, she said this was not one of them. She gave patient flonase, mucinex, tylenol, and sent patient home to rest. Patient also started on Augmentin antibiotics at the same time (which patient took for 7 days) just in case patient might have an infection. Few days later, Patient started to cough up some blood along with minimal phlegm, and visited the Clinic for the second time. Patient's doctor thought perhaps patient having a rare side effect of the vaccine which irritated patient lungs and causes bleeding. She advised patient to go to Hospital Emergency Room (ER) immediately if patient cough up any more blood. Patient's doctor said patient would need a computerized tomography (CT) Scan. The night of 08-APR-2021, patient got much worse, patient was coughing constantly, and mostly coughing up blood. The early morning of 09-APR-2021, patient was at Hospital ER. Patient's doctor said Patient White blood cell (WBC) is 27000, which is almost 3 times the max value, and patient platelets were close to double the max value. Patient's doctor said patient is at risk for sepsis, and had to be admitted immediately. Patient was at Hospital from 09-APR-2021 to 13-APR-2021. Patient was tested for Covid, Influenza A, B, Methicillin-resistant Staphylococcus aureus (MRSA), etc. All came negative. Patient was given azithromycin, rocephin, and at the time patient recently completed a full dose of Augmentin. Patient body did not respond much to all the antibiotics, patient White blood cell (WBC) came down 20000, and the afterward went back up to 25400. Then, the patient's doctor thought patient might have Tuberculosis. 4 tubes of blood were withdrawn and sent to Indianapolis to be incubated for Gold interferon TB test, Patient was also given a purified protein derivative (PPD) test, and patient bloody sputum was sent to Indianapolis for Acid-Fast Bacillus (AFB) Smear and Nucleic Acid test. In the meantime, patient continued to cough up blood at Reid for 3 nights. Patient was then given antibiotics; Vancomycin, Cefepime, Levaquin, and some of patient values partially came back to normal, and patient was released on 13-APR-2021. As of last week, Infectious Disease specialist, patient's doctor told patient all of Tuberculosis (TB) results came negative, hence, they ruled out Tuberculosis (TB). Patient had a swab and a Polymerase chain reaction (PCR) test that day. The action taken with covid-19 vaccine ad26.cov2.s was not applicable. The patient was recovering from irritated lungs and bleeding, and had not recovered from fever, dry coughing, unusual sounds from left lung bottom, coughing up blood and phlegm, and sepsis. This report was serious (Hospitalization Caused / Prolonged).; Sender's Comments: V0.20210451816-COVID-19 VACCINE AD26.COV2.S_-sepsis,heamoptysis,pulmonay heamorrage,breath sounds abnormal. This event(s) is considered unassessable. The event(s) has a compatible/suggestive temporal relationship, is unlabeled, and has unknown scientific plausibility. There is no information on any other factors potentially associated with the event(s).