Hives all over; allergic reaction; constantly full of hives and they itch and they hurt; constantly full of hives and they itch and they hurt; This is a spontaneous report  received from a contactable consumer (patient). A 70-year-old female patient received BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE), dose 2 via an unspecified route of administration, administered in left upper arm on 19Feb2021 13:00 (Lot Number: EL9261) as 2ND DOSE SINGLE DOSE for covid-19 immunisation. Patient took the first dose of vaccine on 01Feb2021 01:00PM (Lot Number: EN5318) in left upper arm for covid-19 immunization. Prior to vaccination, the patient was not diagnosed with COVID-19. Since the vaccination, the patient has not been tested for COVID-19. Medical history included, hyperthyroidisim from the early 1995, acid reflux patient was diagnosed about in 2004, gastrooesophageal reflux disease (GERD). Known allergies included NOAK. Concomitant medications included levothyroxine sodium (SYNTHYROID) taken for hyperthyroidisim, start and stop date were not reported; famotidine taken for acid reflux, start and stop date were not reported; calcium; fish oil, vitamins, all taken for an unspecified indication, start and stop date were not reported. The patient experienced hives all over (medically significant) on 03Mar2021 with outcome of not recovered, constantly full of hives and they itch and they hurt (medically significant) in Mar2021 with outcome of not recovered, allergic reaction (medically significant) in Mar2021 with outcome of not recovered. On 03Mar2021, 12 days after getting the second vaccine, patient started getting hives and still has them. She has been to 3 doctors and an allergist. She has used steroid creams, had a steroid shot, and taken Prednisone. Patient stated that the hives fluctuate in their severity. There has been days that they were so bad, she had to miss work. Yesterday was horrible but she went on to work. Today she could not go to work because they are so bad. The hives are from her scalp to the bottom of her feet and everywhere in between. Mentioned later that the hives were on her lips also. Doctor ran a series of labs on her and the allergist also ran a series of labs on her. She hasn't had a follow up appointment to discuss labs with allergist yet. She must not be dying because they didn't call her right away and laughs. On 03Mar2021, patient broke out in hives, she has had hives continuously since 03Mar, 04Mar, it was around midnight when it started effecting. She has been to many doctors appointment seeing an allergist now, nothing was helping. She has never been allergic to anything in the entire life never. Just constant hives, she has not had, she was just constantly full of hives and they itch and they hurt. She has had the entire body cover, face, scalp, feet everywhere in between. Yesterday was a horrible day, they were huge and they hurt and they itch then patient put steroid medicine on them twice a day like she was supposed to that's the doctors had told to, well she likes to report what's happening because she has never been allergic she never had hives in whole life. She was itching everywhere, it's just horrible. Patient just been using topical medications, creams, steroid creams. She has a steroid shot, took Prednisone for over a week, pills and now she was taking different pills for the allergist have given to her but that will not  been seeing him for two weeks but  it hasn't  helped it all. On 03Mar2021, she started having hives from her scalp to the bottom of her feet and they are itchy. She believed she was having an allergic reaction after the second dose. The adverse event resulted in Doctor or other healthcare professional office/clinic visit, Emergency room/department urgent care.