IgAN with acute tubular injury and RBC casts; Acute tubular injury; two weeks later SCr was 1.5 mg/dl; This literature-non-study case was reported in a literature article and describes the occurrence of IGA NEPHROPATHY (IgAN with acute tubular injury and RBC casts) and RENAL TUBULAR INJURY (Acute tubular injury) in a 66-year-old male patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.   LITERATURE REFERENCE: (privacy)    Concurrent medical conditions included Atrial fibrillation (with baseline SCr 1.1 mg/dl).   On an unknown date, the patient received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On an unknown date, received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On an unknown date,  after starting mRNA-1273 (Moderna COVID-19 Vaccine), the patient experienced IGA NEPHROPATHY (IgAN with acute tubular injury and RBC casts) (seriousness criterion medically significant), RENAL TUBULAR INJURY (Acute tubular injury) (seriousness criterion medically significant) and BLOOD CREATININE INCREASED (two weeks later SCr was 1.5 mg/dl). At the time of the report, IGA NEPHROPATHY (IgAN with acute tubular injury and RBC casts), RENAL TUBULAR INJURY (Acute tubular injury) and BLOOD CREATININE INCREASED (two weeks later SCr was 1.5 mg/dl) outcome was unknown.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On an unknown date, Biopsy kidney: igan with acute tubular injury and rbc casts. he w IgAN with acute tubular injury and RBC casts. He was treated conservatively. On an unknown date, Blood creatinine: 1.1 mg/dl 1.1 mg/dl, 1.5 mg/dl 1st dose of Moderna vaccine and two weeks later 1.5 mg/dl, 2.4 mg/dl Eight weeks after the 2nd dose 2.4 mg/dl and. On an unknown date, Protein urine: 1.2 g/d 1.2 g/d. On an unknown date, Urine analysis: 51-100 rbc/hpf 51-100 RBC/hpf.     For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown), the reporter considered IGA NEPHROPATHY (IgAN with acute tubular injury and RBC casts) to be possibly related. No further causality assessments were provided for RENAL TUBULAR INJURY (Acute tubular injury) and BLOOD CREATININE INCREASED (two weeks later SCr was 1.5 mg/dl).    No concomitant information were reported.  Treatment for the event was not provided.  This case concerns a 66-year-old male patient with no relevant medical history, who experienced the unexpected non serious event of Blood creatinine increased and the serious event of IgA nephropathy and Renal tubular injury after mRNA- 1273 Moderna vaccine. The event Blood creatinine increased 2 weeks after the first dose  of mRNA- 1273 vaccine, IgA nephropathy and Renal tubular injury occurred approximately 8 weeks after the second dose. Creatine was 1.1 mg/dl at baseline, 1.5 mg/dl 2 weeks after the first dose and   2.4 mg/dl 8 weeks after the second dose. Laboratory after the second dose also showed microhaematuria and proteinuria. Kidney biopsy revealed IgA nephropathy with acute tubular injury and RBC casts. The rechallenge is not applicable, since the  disease was diagnosed after the second dose. The benefit-risk relationship of mRNA- 1273 vaccine / Moderna COVID-19 Vaccine is not affected by this report.   This case was linked to MOD-2021-380930 (Patient Link).   Reporter did not allow further contact   Most recent FOLLOW-UP information incorporated above includes: On 11-Nov-2021: Follow up received by safety 12-Nov-2021 included an Email with FTA received from SARA team and does not contain any new information.; Sender's Comments: This case concerns a 66-year-old male patient with no relevant medical history, who experienced the unexpected non serious event of Blood creatinine increased and the serious event of IgA nephropathy and Renal tubular injury after mRNA- 1273 Moderna vaccine. The event Blood creatinine increased 2 weeks after the first dose  of mRNA- 1273 vaccine, IgA nephropathy and Renal tubular injury occurred approximately 8 weeks after the second dose. Creatine was 1.1 mg/dl at baseline, 1.5 mg/dl 2 weeks after the first dose and   2.4 mg/dl 8 weeks after the second dose. Laboratory after the second dose also showed microhaematuria and proteinuria. Kidney biopsy revealed IgA nephropathy with acute tubular injury and RBC casts. The rechallenge is not applicable, since the  disease was diagnosed after the second dose. The benefit-risk relationship of mRNA- 1273 vaccine / Moderna COVID-19 Vaccine is not affected by this report