severe pain in vagina; Bad shakes; Boosted her immune system; Feels like her body has changed/her body has become heightened and it is attacking the weak parts of her body and no medication is working; she states her body is attacking itself; Cant sleep; Severe pain in bladder; Severe pain in the lower part of her body/ a lot of pain/ severe pain; Urinary tract like symptoms/received an email which says she had a tooth ache which is completely wrong, she had a urinary tract like infections in her bladder and vaginal area; she has IC, Interstitial cystitis; she has never had autoimmune problems before; Vagina atrophy; Fever; Shivers; Covid rash; This spontaneous case was reported by a consumer and describes the occurrence of VULVOVAGINAL PAIN (severe pain in vagina), TREMOR (Bad shakes), THERAPEUTIC RESPONSE UNEXPECTED (Boosted her immune system), FEELING ABNORMAL (Feels like her body has changed/her body has become heightened and it is attacking the weak parts of her body and no medication is working; she states her body is attacking itself) and SLEEP DISORDER (Cant sleep) in a 54-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     No medical history was provided by the reporter.  Concomitant products included TOLTERODINE L-TARTRATE (DETROL) for an unknown indication.   On an unknown date, the patient received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On an unknown date, received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. On an unknown date, the patient experienced VULVOVAGINAL PAIN (severe pain in vagina), TREMOR (Bad shakes), THERAPEUTIC RESPONSE UNEXPECTED (Boosted her immune system), FEELING ABNORMAL (Feels like her body has changed/her body has become heightened and it is attacking the weak parts of her body and no medication is working; she states her body is attacking itself), SLEEP DISORDER (Cant sleep), BLADDER PAIN (Severe pain in bladder), PAIN (Severe pain in the lower part of her body/ a lot of pain/ severe pain), URINARY TRACT DISORDER (Urinary tract like symptoms/received an email which says she had a tooth ache which is completely wrong, she had a urinary tract like infections in her bladder and vaginal area), CYSTITIS INTERSTITIAL (she has IC, Interstitial cystitis), IMMUNE SYSTEM DISORDER (she has never had autoimmune problems before), ATROPHIC VULVOVAGINITIS (Vagina atrophy), PYREXIA (Fever), CHILLS (Shivers) and RASH (Covid rash). The patient was treated with ESTROGENS CONJUGATED (PREMARIN) at an unspecified dose and frequency; ESTRADIOL (YUVAFEM) at an unspecified dose and frequency and SOLIFENACIN at an unspecified dose and frequency. At the time of the report, VULVOVAGINAL PAIN (severe pain in vagina), TREMOR (Bad shakes), THERAPEUTIC RESPONSE UNEXPECTED (Boosted her immune system), FEELING ABNORMAL (Feels like her body has changed/her body has become heightened and it is attacking the weak parts of her body and no medication is working; she states her body is attacking itself), SLEEP DISORDER (Cant sleep), BLADDER PAIN (Severe pain in bladder), PAIN (Severe pain in the lower part of her body/ a lot of pain/ severe pain), URINARY TRACT DISORDER (Urinary tract like symptoms/received an email which says she had a tooth ache which is completely wrong, she had a urinary tract like infections in her bladder and vaginal area), CYSTITIS INTERSTITIAL (she has IC, Interstitial cystitis), IMMUNE SYSTEM DISORDER (she has never had autoimmune problems before), ATROPHIC VULVOVAGINITIS (Vagina atrophy), PYREXIA (Fever), CHILLS (Shivers) and RASH (Covid rash) outcome was unknown.            Most recent FOLLOW-UP information incorporated above includes: On 28-Jul-2021: Follow up information received: Additional events are added.