This is a spontaneous report from a Pfizer-sponsored program, Pfizer RXPathways. A contactable consumer (patient) reported that a 65-year-old male patient received the first dose of PREVNAR 13 (batch number, lot number, and expiration date unknown), via an unspecified route of administration in the right arm at a single dose for immunization (recommended once he turned 65) and the first dose of FLUZONE (SUBVIRION: HD 17-18) batch number, lot number, and expiration date unknown) via an unspecified route of administration in the left arm at 0.5 ml, single (injection once) for immunisation (annual flu vaccine); both on 10Dec2017 14:00. Medical history included joint pain, total hip replacement in 2014 (right hip), malignant hypertension diagnosed years ago. Family history includes hives (mom used to get hives when get hives when she would take different medications), allergic to penicillin, amoxicillin, and cephalosporin (3 sons, they break out in hives and can't take it). The patient's concomitant medications were not reported. The patient previously took clopidogrel bisulfate (PLAVIX) for blockage on LAD as well as higher doses of unspecified statins. The patient is also allergic to ibuprofen and can't breathe when he takes it. This has happened to him twice. One of these happened 2 weeks ago Nov2017 but he has recovered completely. The patient also previously received flu shots (influenza vaccine) 11 or 12 years he received a regular flu shot. He thinks it was 2005 or 2006. He received a regular flu shot at his doctor's office. He had a rash and felt he couldn't breathe right. He went back to the doctor's office and his blood pressure was real high. This was probably 2-4 years ago. On 10Dec2017, the patient experienced redness on his face and arms at 14:00 and he was itchy at 14:15. The caller stated he had an influenza vaccine shot the day before and they also gave him the pneumococcal 13-valent conjugate vaccine (diphtheria CRM197 protein) shot right after and he started getting redness on his face and arms and he was itchy. He stated this was the first time he received this higher dose flu shot. The pharmacist was a little nervous to give it to him due to his cardiac health history, but she did. He received the vaccines in different arms about 10 minutes apart. His arm was red almost immediately followed by his face. The itching started probably about 15 minutes after the vaccine. The patient took diphenhydramine (BENADRYL) and famotidine (PEPCID) and reported that his symptoms improved. His friend is an ER doctor and told him the famotidine would also help relieve his symptoms. Additionally, it was reported that the patient came home and was reading about the vaccine and wanted to know if having the flu shot with PREVNAR 13 will weaken the vaccine. patient mentioned that he had read the package insert and that it will be less effective since he got it together with the flu shot. He was concerned if it was given correctly together with the flu shot.He said that it was not that he could not afford it but for him it should not be given together with the flu shot if the products effect will diminish its effect. The patient was not comfortable and was quite anxious that the product will diminish its effect. It was the first time that the patient had received the Pfizer vaccine and was not sure if he would get the vaccine again. The patient did not undergo relevant tests. The events did not require visit to the emergency room or physician office. Outcome of the events of redness on his face and arms and itchy was recovering, reported as improved. Information on lot number, batch number, and expiration date have been requested.