mild soreness; low grade fever/fever (lowgrade) x 6 hours; This is a spontaneous report received from a contactable reporter(s) (Pharmacist). The reporter is the patient.  67-year-old female patient (not pregnant) received bnt162b2 (BNT162B2), intramuscular, administered in arm left, administration date 19Feb2021 18:00 (Lot number: FL9269) at the age of 67 years as dose 2, single for covid-19 immunization. Relevant medical history included: "knee replacements", start date: Oct2020, stop date: Oct2020, notes: knee replacements in Oct2020; "Weakened immune system" (Use of medications that suppress the immune system (e.g., high-dose of corticosteroids, cyclosporine, methotrexate, azathioprine, and biologic therapies like rituximab and etanercept): Infliximab (Remicade) TNF blocker), (unspecified if ongoing); "mild hypothyroidism", start date: 2019 (ongoing), notes: take Synthroid (levothyroxine); "ulcerative colitis (inflammatory)", start date: 2019 (ongoing), notes: Use Remicade with 10 wks infusion; "CA Rt breast", start date: 2002, stop date: Jul2002, notes: Lumpectomy- no lymph node involvement 4x chemo + radiation Recurrence 19 years; "Reason for use: anti-inflammatory" (unspecified if ongoing); "pain" (unspecified if ongoing); "retired" (unspecified if ongoing). Concomitant medication(s) included: CELEBREX taken for inflammation, start date: 2020 (ongoing); ACETAMINOPHEN taken for pain (ongoing); LEVOTHYROXINE taken for hypothyroidism (ongoing). Past drug history included: Cipro, reaction(s): "Known allergies: CIPRO", notes: Known allergies: CIPRO.; Remicade, reaction(s): "UC", notes: UC-remission with Remicade. Vaccination history included: Bnt162b2 (Dose Number: 1, Batch/Lot No: EN5318, Location of injection: Arm Left, Vaccine Administration Time: 06:00 PM, Route of administration: Intramuscular), administration date: 29Jan2021, when the patient was 67 years old, for Covid-19 immunization, reaction(s): "slight soreness". The following information was reported: PAIN (non-serious), outcome "unknown", described as "mild soreness"; PYREXIA (non-serious), outcome "unknown", described as "low grade fever/fever (low-grade) x 6 hours". Relevant laboratory tests and procedures are available in the appropriate section. Therapeutic measures were taken as a result of pain, pyrexia.  Additional information: Patient did not receive other vaccine in four weeks; Patient not had Covid prior vaccination; Nor tested for Covid post vaccination. Received other medications. Vaccination facility type was reported as pharmacy or Drug store. The patient received third dose of Pfizer on 07Sep2021, 04:00 PM (lot number: FF2588); (anatomical location: Left arm). It was reported that patient had Remicade infusion on 08Jul2021. Patient had no reaction to first vaccine; After her second dose she experienced mild soreness and low-grade fever for a few hours. However, on the third dose. She had fever of 103 plus degrees for FOUR (4) DAYS, then it began to fall gradually over next three days; severe exhaustion; no redness, but severe pain on left arm from hand to shoulder, up neck to left ear and around base of head, down across left shoulder blade on back to midline, pain radiated on front of chest to midline; could not raise the arm for 2days. Chills- significant chills x 2 days; Exhaustion fatigue- 1 week. Nothing long lasting or permanent just more of an excessive AE over a week. she expected some reaction, but this seemed excessive, and her PCP now says no more COVID vaccines. She saw a fourth vaccine recommended former due to health status (immunosuppressed due to Remicade use for UC). so now she was concerned about taking a 4th dose of vaccine. Upon follow-up (15Nov2021): A spontaneous report from a contactable Pharmacist. This Pharmacist reported in response to HCP letter sent in a cross referenced that included: When asked about the patient's condition, weakened immune system; If the reason is a weakened immune system, please select one of the conditions below: Use of medications that suppress the immune system (e.g., high dose of corticosteroids, cyclosporine, methotrexate, azathioprine, and biologic therapies like rituximab and etanercept): Infliximab (Remicade) TNF blocker. Patient reported this information because she was one of those auto-immune patients not studied or not studied well in COVID vaccine testing/trials. she thought this might be useful to get a feel for how booster reacted after 8 plus weeks post Remicade.  Follow-up attempts are completed. No further information is expected.