heart start hurting on Monday with almost each breath; BPM was also extremely high and resting was about 99; blood pressure jumped extremely; This is a spontaneous report from a contactable other healthcare professional (HCP, patient herself). A 37-year-old female patient received BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE, Solution for injection), via an unspecified route of administration, administered in the left arm on 22Apr2021 at 18:00 (batch/lot number and expiration date were not reported) as the 2nd dose, single for COVID-19 immunization. The facility where the most recent COVID-19 vaccine was administered was reported as the pharmacy or drug store. The patient previously received the first dose of BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE, lot number: ER8733) on 31Mar2021 at 04:00 PM (at the age of 37 years old) in the left arm and experienced terrible pain in her arm. Relevant medical history included ongoing hypertension/high blood pressure (BP), which was controlled; ongoing Hashimoto; ongoing chronic herpes; and known allergies to Penicillin. The patient's concomitant medications were not reported. The patient previously took celecoxib (CELEBREX), from which the patient had known allergies. The patient was 37 years old and was not pregnant at the time of vaccination. The patient did not receive any other vaccines within 4 weeks prior to the COVID vaccine. Prior to vaccination, the patient was not diagnosed with COVID-19. Since the vaccination, it was unknown if the patient had been tested for COVID-19. After the second vaccine on 23Apr2021 at 05:00, the patient's blood pressure (bp) jumped extremely and lasted for at least five days. The patient had to monitor and had taken a lot of medication to keep it stable and not to pass the low blood bp of 110. It almost did one day. The patient's heart started hurting on Monday (26Apr2021) with almost each breath. The patient's beats per minute (bpm) was also extremely high and resting was about 99 on 24Apr2021. The patient stated that she was "not chainring" the regular symptoms of the flu such as fever, chills, sweating, exhaustion, and headache; her heart suffered the most. The adverse events (AE) resulted in a doctor or other healthcare professional office/clinic visit. The reporter assessed the events as non-serious. Therapeutic measures were taken as a result of blood pressure jumped extremely, which included series of BP medicine and "different hours" (as reported). The patient recovered from the event "blood pressure jumped extremely" on 28Apr2021, while she was recovering from the rest of the events.  Information on the batch/lot number has been requested.; Sender's Comments: Based on chronological connection to the vaccine a causal relationship between event angina pectoris and BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE0 cannot be excluded. The impact of this report on the benefit/risk profile of the Pfizer product is evaluated as part of Pfizer procedures for safety evaluation, including the review and analysis of aggregate data for adverse events. Any safety concern identified as part of this review, as well as any appropriate action in response, will be promptly notified to Regulatory Authorities, Ethics Committees and Investigators, as appropriate.