itching eyes; heart rate increase; blood pressure went up; felt something in the throat; chest to be heavy; This is a spontaneous report from a contactable consumer (patient).   A 68-years-old female patient received bnt162b2 (PFIZER-BIONTECH COVID-19 mRNA VACCINE, Solution for injection, Batch/Lot Number: EN6201), via an unspecified route of administration, administered in Arm Left on 10Feb2021 15:45 (at the age of 68-years-old) as dose 1, single for covid-19 immunisation. Medical history included Blood pressure high from 2019 and ongoing, High cholesterol from 2019 to an unknown date,  sleep disorder from 2018 to an unknown date, depression from 2020 to an unknown date, constipation from an unknown date and unknown if ongoing. Concomitant medications included meloxicam from 27Jan2021 and ongoing (following a car accident, as reported); clonidine taken for blood pressure measurement from 2019 and ongoing; clonazepam taken for sleep disorder from 2018 and ongoing; spironolactone taken for blood pressure measurement from an unspecified start date and ongoing (at least 5 years, as reported); pravastatin sodium taken for blood cholesterol increased from 2019 and ongoing; melatonin taken for sleep disorder from Feb2021 and ongoing; macrogol 3350 (MIRALAX) taken for constipation from an unspecified start date and ongoing (2016, as reported) and Trentalis taken for depression from 2020 and ongoing. Reportedly, Caller states, I was told I would have to stay 30 minutes, they gave me Benadryl and Pepcid, they monitored me, everything resolved by the next day, I felt as if the heaviness was still in my chest, but I was released and a neighbor picked me up, they didn't want me driving, if I had further distress. I have talked to my primary care said, and my primary care doctor said no, my allergist said no, and another doctor said no, and one that worked with the other doctor said go ahead and take it as well as one other physician. When I say fast heartbeat, I didn't feel it until I was in the observation room. I noticed the change when I got in the observation room. She is due to get the second dose tomorrow. I was told to take it about 45 minutes before I came back before my second dose. I don't know if you guys would be able to go as far as recommending I take the second dose or not. On 10Feb2021,as reported, within 15 to 20 minutes after the vaccination, the patient experienced itching eyes, heart rate increase, blood pressure went up, felt something in the throat and chest to be heavy. Therapeutic measures were taken as a result of adverse events. Outcome of the events itching eyes, heart rate increase, blood pressure went up recovered on 10Feb2021 and other events was recovered on 11Feb2021.  Additional Context: Caller received the first dose of the Covid-19 vaccine on 10Feb2021. She had mild reactions to the vaccine. Her eyes were itching, her heart rate sped up, her blood pressure went up and she felt like something was in her throat. The nurse gave her Benadryl and Pepcid. After monitoring her for an hour she was able to go home. She is due to get the second dose tomorrow. Is Benadryl and Pepcid recommended before the second dose. Would Benadryl diminish the efficacy of the vaccine. Caller was advised to not take the second dose. After she took Benadryl her eyes calmed down in a half hour. The increased heart rate and blood pressure lasted for an hour. She saw an allergist on 23Feb2021. They tried to test the itching. The degree of redness that they wanted was so inconclusive. She emailed her doctor the next day after she received the vaccine. The doctor emailed her back and told her to not take the second dose. Two weeks before the vaccine she had a physical. She was in a car crash in Dec2020. Her doctor prescribed Meloxicam.   No follow-up attempts are possible. No further information is expected.