felt like I had a double ear infection; pain in my head/had stabbing pains in head that came on quickly and left just as quickly; sweating; migraine; fever; shaking; Vomiting and once body empty of fluids was retching or dry heaving for hours; Was able to shower but was incredibly weak; Sitting up only lasted 20 minutes and caller had to get back in bed; caller hadn't eaten anything but sips of water and Gatorade; pretty drained from the experience; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP) from medical information team. The reporter is the patient.  A 71-year-old female patient received BNT162b2 (BNT162B2), on 19May2022 at 16:00 as dose 4 (booster), single (Lot number: FM7553) at the age of 71 years, in left arm for covid-19 immunisation. The patient's relevant medical history included: "carpal tunnel", start date: 07Mar2022 (ongoing). The patient's concomitant medications were not reported. Vaccination history included: BNT162b2 (Dose 1, Route of administration: left arm), administration date: 12Mar2021, when the patient was 70-year-old, for Covid 19 immunization, reaction(s): "Doesn't know if after first or second dose Vaccine, had normal aches and was really fatigued for two days"; BNT162b2 (Dose 1, Route of administration: left arm), administration date: 12Mar2021, when the patient was 70-year-old, for covid 19 immunization, reaction(s): "Doesn't know if after first or second dose Vaccine, had normal aches and was really fatigued for two days"; BNT162b2 (Dose 2, Route of administration: left arm), administration date: 01Apr2021, when the patient was 70-year-old, for covid 19 immunization, reaction(s): "Doesn't know if after first or second dose Vaccine, had normal aches and was really fatigued for two days", "Doesn't know if after first or second dose Vaccine, had normal aches and was really fatigued for two days"; BNT162b2 (Dose 3, lot: FA8028 , NDC: unknown , Expiration: Unknown , Route of administration: left arm), administration date: 03Nov2021, when the patient was 71-year-old, for covid 19 immunization; Flu vaccine (Caller received Flu vaccine in Fall of 2021 but clarifies the Flu Vaccine was not received within 4 weeks prior to any dose of the Pfizer Vaccine.), administration date: 2021; Flu vaccine (Caller received Flu vaccine in Fall of 2021 but clarifies the Flu Vaccine was not received within 4 weeks prior to any dose of the Pfizer Vaccine.), administration date: 2021, for immunisation.  The following information was reported: EAR INFECTION (hospitalization), outcome "recovered", described as "felt like I had a double ear infection"; HEADACHE (hospitalization), outcome "unknown", described as "pain in my head/had stabbing pains in head that came on quickly and left just as quickly"; HYPERHIDROSIS (hospitalization), outcome "unknown", described as "sweating"; MIGRAINE (hospitalization), outcome "unknown"; PYREXIA (hospitalization), outcome "recovered", described as "fever"; TREMOR (hospitalization), outcome "unknown", described as "shaking"; VOMITING (hospitalization), outcome "recovered", described as "Vomiting and once body empty of fluids was retching or dry heaving for hours"; ASTHENIA (non-serious), outcome "unknown", described as "Was able to shower but was incredibly weak"; BEDRIDDEN (non-serious), outcome "unknown", described as "Sitting up only lasted 20 minutes and caller had to get back in bed"; DECREASED APPETITE (non-serious), outcome "unknown", described as "caller hadn't eaten anything but sips of water and Gatorade"; FATIGUE (non-serious), outcome "unknown", described as "pretty drained from the experience". The patient underwent the following laboratory tests and procedures: Electromyogram: (19May2022) Unknown result, notes: a nerve test with electrical impulses for carpal tunnel to measure severity; Pyrexia: (unspecified date) Unknown result.  Clinical course: The patient stated after receiving the second booster of the Pfizer-BioNTech COVID-19 vaccine she had a migraine that felt like incredible stabbing pain in her head. She has not had migraines in years when she did she vomited but not as severely as a she did after this, she vomited until she had no more in her. She felt like she had a double ear infection, had a fever, was sweating, shaking and she was unable to eat. This happened when she got out of bed and tried to sit up and lasted 20 minutes, it was so bad she had to call and go to the ER. She was okay now. she felt back to normal, but it was very awful. Her doctors have not really heard of anything as severe. She asked any information on severe migraine, sweating, inability to eat, shaking, vomiting, double ear infection like sensation reports after receiving the second booster of the Pfizer-BioNTech COVID-19 vaccine. The patient received the Second booster Pfizer Vaccine at 1600 and had a really severe reaction, nothing like caller had experienced with original Pfizer Vaccine shots. Doesn't know if after first or second dose Vaccine, had normal aches and was really fatigued for two days. She doesn't know if it was after first or second dose Pfizer Vaccine, but the caller had normal aches and was really fatigued for two days. The normal aches and fatigue were no big deal. She had a skull splitting migraine headache with the Pfizer Vaccine Second Booster Dose, she woke up at 3AM and flipped a switch. The patient did not have a migraine in years, the migraine was horrible. The migraine was not only incredibly horrible stabbing pain in head. On top of the constant migraine pain. The patient was vomiting, and once body was empty of fluids was retching or dry heaving for hours and kept throwing up and not bringing anything up. She had a fever, was sweating and shaking. She was trying to keep hydrated with water and Gatorade. Just taking teeny sips, so afraid of retching more. This skull splitting migraine headache, vomiting, and retching, feeling like had double ear infection and trying to keep hydrated all occurred on 19May2022. Was in bed orin the bathroom until Saturday afternoon, 21May2022. She was in the bed or in the bathroom until Saturday afternoon, 21May2022. She does not know where caller is, regarding dates. She forced self to get out of bed and sit on couch and try to drink Gatorade. Sitting up only lasted 20 minutes and had to get back in bed. Meanwhile, she hadn't eaten anything but sips of water and Gatorade. The intense migraine lasted 8-10 hours, not exactly sure how long migraine lasted because wasn't able to look at anything. Sunday, 22May2022, caller still had headache, just a dull headache and could manage4 the headache. Every once in a while, had stabbing pains in head that came on quickly and left just as quickly. The pains were very sharp. The patient was able to shower but was incredibly weak feeling. By Monday, 23May2022 the caller woke up and felt normal. The caller patient was pretty drained from the experience but was able to go to work. The AE(s) did not require a visit to emergency room or physician office but came close to going to emergency room, was really scared because of pain.