Immunotherapy was no longer working/had another mass; Immunotherapy was no longer working was reported as worsened/had another mass; Having more issues with breathing; emphysema; This is a spontaneous report from a contactable consumer (patient). An 80-years-old female elderly patient received bnt162b2 (PFIZER-BIONTECH COVID-19, Solution for injection, Lot Number: EN6201, expiration: not reported), intramuscular, administered in arm left on 18Feb2021 at 18:00-18:30 as second dose, single for covid-19 immunization(at the age of 80years). Medical history included cancer. No additional vaccines administered on same date of the Pfizer suspect. No prior vaccinations within 4 weeks. Other and family medical history was none.Concomitant medications included prednisone -1mg daily; was a higher dose back when she started and was now decrease,) taken for polymyalgia from Oct2020 to an unspecified stop date; pembrolizumab (KEYTRUDA) taken for Stage 3 Lung Adenocarcinoma (non-small cell) from 02Jan2021 to an unspecified stop date, infused once every 3 weeks; received infusion at chemotherapy center; no sample of the product available to be returned, packaging sealed and intact.  Previously, the patient received historical vaccine of BNT162B2 (PFIZER-BIONTECH COVID-19, Solution for injection, Lot EL9265, expiration was unknown) injected intramuscularly, administered in upper arm left on 28Jan2021 as first dose, single for covid-19 immunisation , barely felt it and no adverse event following prior vaccinations. The patient received it and was going through immunotherapy cancer treatment and was doing well. On 05Feb2021, she saw her in her office and was doing well with shrinkage and treatment with first mass, can decrease to once a month instead of 3 weeks. Then when she had second shot she just found out it got bigger. It was reported that on 07Apr2021, she got a CT scan and it showed she had another mass. She saw CT result sooner but did not discuss with her doctor until then. The CT scan also had emphysema (Start date: 2021) which she was not aware of as no one had ever verbally talked to her about that before. She saw the doctor on 14Apr2021 09:30, and said immunotherapy is no longer working. Her doctor wanted to stop the Keytruda, since it was not working, but they agreed to continue for 3 more sessions and do another scan after that. She has had things get worse, since she has a new mass and is having more issues with breathing since saying the immunotherapy is no longer working. One infusion of KEYTRUDA was skipped and then started again to see if it will kick in and start up again. The patient was wondering how the best way was to report a possible link and her immuno-therapy. Back when the vaccine first come out, it was questionable if cancer patients should or would get the vaccine and then they decided yes, and she did it. She would like to know if Pfizer was doing any further follow up with that population and was there any new info on cancer patients who have received the vaccine and whether are monitoring that. The patient underwent lab tests and procedures which included CT which showed she had another mass and emphysema on 07Apr2021. No other relevant test. Outcome for more issues with breathing was unknown and for rest of the events was not recovered.  Information about lot/batch number has been requested.