knees have been getting progresively worse; they feel swollen / knee swelling; knee stiff especially in the mornings; knee pain / uncomfortable to actually bend my knees; Noticeable fatigue, increasing in intensity; T-103.4; Chills; Arm became extremely sore; Felt like arm was swollen to wrist; Appetite lost/Anorexia; Drowsy; Weight loss during period approximately 4 pounds; Pain at injection site; General muscular pain/Aches; This spontaneous case was reported by a consumer and describes the occurrence of PAIN IN EXTREMITY (Arm became extremely sore), PERIPHERAL SWELLING (Felt like arm was swollen to wrist), DECREASED APPETITE (Appetite lost/Anorexia), SOMNOLENCE (Drowsy) and WEIGHT DECREASED (Weight loss during period approximately 4 pounds) in a 56-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 002A21A and 012L20A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     Concurrent medical conditions included Nickel sensitivity and Hypothyroidism post ablative since 14-Mar-2018. Concomitant products included HYDROCHLOROTHIAZIDE, LOSARTAN POTASSIUM (LOSARTAN/HYDROCHLOORTHIAZIDE) from 23-Mar-2019 to an unknown date for Essential hypertension, LEVOTHYROXINE from 13-Mar-2018 to an unknown date for Hypothyroidism.   On 05-Feb-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 05-Feb-2021 at 2:45 PM, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. On 05-Mar-2021, the patient experienced WEIGHT DECREASED (Weight loss during period approximately 4 pounds), VACCINATION SITE PAIN (Pain at injection site) and MYALGIA (General muscular pain/Aches). On 06-Mar-2021, the patient experienced PAIN IN EXTREMITY (Arm became extremely sore), PERIPHERAL SWELLING (Felt like arm was swollen to wrist), DECREASED APPETITE (Appetite lost/Anorexia), SOMNOLENCE (Drowsy), PYREXIA (T-103.4), CHILLS (Chills) and FATIGUE (Noticeable fatigue, increasing in intensity). In April 2021, the patient experienced ARTHROPATHY (knees have been getting progresively worse), JOINT SWELLING (they feel swollen / knee swelling), JOINT STIFFNESS (knee stiff especially in the mornings) and ARTHRALGIA (knee pain / uncomfortable to actually bend my knees). The patient was treated with PARACETAMOL (TYLENOL) ongoing since an unknown date for Adverse event, at a dose of UNK dosage form. On 09-Mar-2021, PAIN IN EXTREMITY (Arm became extremely sore), PERIPHERAL SWELLING (Felt like arm was swollen to wrist), DECREASED APPETITE (Appetite lost/Anorexia), SOMNOLENCE (Drowsy), WEIGHT DECREASED (Weight loss during period approximately 4 pounds), VACCINATION SITE PAIN (Pain at injection site), PYREXIA (T-103.4), CHILLS (Chills), MYALGIA (General muscular pain/Aches) and FATIGUE (Noticeable fatigue, increasing in intensity) had resolved. At the time of the report, ARTHROPATHY (knees have been getting progresively worse), JOINT SWELLING (they feel swollen / knee swelling), JOINT STIFFNESS (knee stiff especially in the mornings) and ARTHRALGIA (knee pain / uncomfortable to actually bend my knees) had not resolved.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On 06-Mar-2021, Body temperature: 103.4 (High) 103.4.         Approximately 8 hours post dose 2 administration, the patient had significant pain at the injection site and general muscular pain.  Eighteen hours post dose 2, she had an onset of noticeable fatigue, increasing in intensity.  The patient's arm became extremely sore, felt like the arm was swollen to the wrist.  Her appetite was lost, she had a temperature of 103.4, chills, and was drowsy.  Paracetamol (TYLENOL) reduced the fever, but aches which were now whole body continued.  The patient had ongoing symptoms of fever, aches, and somnolence which gradually reduced over 48 hours.  At 72 hours, mild fatigue and anorexia persisted with a weight loss during the period of approximately 4 pounds.  On 01-JUN-2021, the patient reported over the last couple of months since receiving the second vaccine, her knees have been getting progressively worse, symptoms are ongoing. No treatment information was provided by the reporter for the knee symptoms.   This case was linked to MOD-2021-011678 (Patient Link).   Most recent FOLLOW-UP information incorporated above includes: On 01-Jun-2021: Medical History updated. Concomitant medications updated. 3 events added.