hive is back, horseshoe shaped, red and very itchy; Painful at the injection site; low grade fever; Headache; Achy; Stomach upset; hot to touch at the inejction site; Hive at the injection site then 10 more showed up; 3x5 inch raised and itchy; This spontaneous case was reported by an other health care professional (subsequently medically confirmed) and describes the occurrence of VACCINATION SITE URTICARIA (Hive at the injection site then 10 more showed up; 3x5 inch raised and itchy), VACCINATION SITE PAIN (Painful at the injection site), PYREXIA (low grade fever), HEADACHE (Headache) and ABDOMINAL DISCOMFORT (Stomach upset) in a 53-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch no. 012L20A) for covid-19 vaccination. The occurrence of additional non-serious events is detailed below.     The patient had no drug allergies or any medical history.  Concurrent medical conditions included Allergic reaction to bee sting.    On 08-Jan-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 15-Jan-2021, the patient experienced VACCINATION SITE URTICARIA (Hive at the injection site then 10 more showed up; 3x5 inch raised and itchy). On 16-Jan-2021, the patient experienced VACCINATION SITE WARMTH (hot to touch at the inejction site). On 18-Jan-2021, the patient experienced VACCINATION SITE PAIN (Painful at the injection site), PYREXIA (low grade fever), HEADACHE (Headache), ABDOMINAL DISCOMFORT (Stomach upset) and MYALGIA (Achy). On 21-Jan-2021, the patient experienced VACCINATION SITE URTICARIA (hive is back, horseshoe shaped, red and very itchy). The patient was treated with FEXOFENADINE HYDROCHLORIDE (ALLEGRA) in January 2021 for Adverse event, at a dose of UNK dosage form; CORTISONE (topical) in January 2021 for Adverse event, at a dose of UNK dosage form, tid; FAMOTIDINE (PEPCID [FAMOTIDINE]) in January 2021 for Adverse event, at a dose of UNK dosage form (for a week); DIPHENHYDRAMINE HYDROCHLORIDE (BENADRYL [DIPHENHYDRAMINE HYDROCHLORIDE]) in January 2021 for Adverse event, at a dose of UNK dosage form (for a week); LEVOCETIRIZINE DIHYDROCHLORIDE (XYZAL) in January 2021 for Adverse event, at a dose of UNK dosage form (for a week) and IBUPROFEN in January 2021 for Adverse event, at a dose of 600 mg. On 20-Jan-2021, VACCINATION SITE URTICARIA (Hive at the injection site then 10 more showed up; 3x5 inch raised and itchy), VACCINATION SITE PAIN (Painful at the injection site), PYREXIA (low grade fever), HEADACHE (Headache), ABDOMINAL DISCOMFORT (Stomach upset), VACCINATION SITE WARMTH (hot to touch at the inejction site) and MYALGIA (Achy) had resolved. At the time of the report, VACCINATION SITE URTICARIA (hive is back, horseshoe shaped, red and very itchy) outcome was unknown.        The action taken with mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) was unknown.   For mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular), the reporter did not provide any causality assessments.   Concomitant medication was not reported. The patient used  Pepcid, Benadryl, and xyzal for a week and it was pretty much gone by Wednesday. The patient stopped taking antihistamine because allergist would not see her if she did not stop using antihistamines and hive was back, horseshoe shaped, red and very itchy. The patient had scheduled an appointment with doctor on Monday.