Postural Orthostatic Tachycardia Syndrome (POTS); Autoimmune Disease; Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS); Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS); Information has been received from a lawyer referring to a currently adult male patient of unknown age regarding a case in litigation. Information about concurrent condition, history condition and concomitant medication was not reported. On 19-JUL-2018, at 17 years old, the patient received his third dosage of Quadrivalent Human Papillomavirus (Types 6,11,16,18) Recomb. Vaccine (GARDASIL). The patient agreed to receiving the vaccine injections after having been convinced by marketing by the company, that the vaccine was very safe, that the vaccine prevented human papillomavirus (HPV) infection in males. The patient relied upon the company's ubiquitous representations concerning the safety and efficacy of the vaccine, in consenting to his vaccinations. Prior to receiving his injections, the patient had no autoimmune diseases, and no autonomic issues. He was a high-achieving student. The patient's health care provider recommended that he received the vaccine, which was stated as a safe and effective vaccine for preventing cervical cancer. In light of the doctor's recommendations, as well as the company's relentless marketing and advertising messages, to which the patient and his mother had been exposed concerning the safety and efficacy of the vaccine, the patient and his mother consented to being injected with the vaccine. In September 2018, after his third dose of Quadrivalent Human Papillomavirus (Types 6,11,16,18) Recomb. Vaccine (GARDASIL), the patient was diagnosed with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). He had neither walked nor stood since February 2019 and had been largely bedridden since that time. He needed assistance rolling over, eating, and sitting upright. He had ongoing brain fog that affected his concentration, making it difficult for him to read or have long conversations. He had frequent headaches and stomachaches. He had developed postural orthostatic tachycardia syndrome (POTS) which caused an increased heart rate and low blood pressure when he sat up for very long. Although he was constantly exhausted, he suffered from insomnia and non-restorative sleep. He was completely disabled and entirely dependent on others to care for him. The patient contended that his vaccine injections caused him to develop serious and debilitating injuries, including but not limited to autonomic, neurological, heterogenous autoimmune disease, POTS, and dysautonomia, as well as a constellation of adverse symptoms, complications, injuries, and other adverse events, many of which were alleged herein and all of which were caused by Quadrivalent Human Papillomavirus (Types 6,11,16,18) Recomb. Vaccine (GARDASIL) or otherwise linked to his vaccine-induced autoimmune disorder. As a proximate result of the company's wrongful acts and omissions and its negligent and fraudulent testing, labeling, manufacturing, marketing and promotion of the vaccine, the patient had suffered and continued to suffer severe and permanent physical injuries, and associated symptomology and had suffered severe and permanent emotional injuries, including pain and suffering. The patient also had a substantial fear of suffering additional and ongoing harms, including but not limited to now being at an increased risk of cancer, and future symptoms and harms associated with his autoimmune disease and other injuries caused by Quadrivalent Human Papillomavirus (Types 6,11,16,18) Recomb. Vaccine (GARDASIL). As a direct and proximate result of his vaccine-induced injuries, the patient had suffered and continued to suffer economic losses, including considerable financial expenses for medical care and treatment, and diminished income capacity, and he would continue to incur these losses and expenses in the future. The outcome of the events was not recovered. The causality between the events and Quadrivalent Human Papillomavirus (Types 6,11,16,18) Recomb. Vaccine (GARDASIL) was considered to be related.  The lawyer considered the events to be disability.  Upon internal review, autoimmune disease was determined to be medically significant.