He got more of the rash; Half of his body was covered in welts; This spontaneous case was reported by a patient and describes the occurrence of RASH (He got more of the rash) and URTICARIA (Half of his body was covered in welts) in a 64-year-old male patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 011A21A and 048A21A) for COVID-19 vaccination.     Concurrent medical conditions included Prostate cancer (PSA level was much more aggressive around the time the patient got the shots, came back in 2000) since 1998 and Drug allergy (allergy to Codeine). Concomitant products included COVID-19 VACCINE NRVV AD26 (JNJ 78436735) (JANSSEN COVID-19 VACCINE) from 23-Oct-2021 to an unknown date, RELUGOLIX (ORGOVYX), BICALUTAMIDE (CASODEX), DUTASTERIDE (AVODART) and BISOPROLOL for an unknown indication.   On 05-Mar-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 02-Apr-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 16-Apr-2021, the patient experienced RASH (He got more of the rash). On an unknown date, the patient experienced URTICARIA (Half of his body was covered in welts). The patient was treated with CORTISONE for Welts, at an unspecified dose and frequency. In 2021, RASH (He got more of the rash) had resolved. At the time of the report, URTICARIA (Half of his body was covered in welts) had resolved.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): In 2021, Prostatic specific antigen: PSA levels were much more aggressive.         Two weeks after the second dose, the patient had a rash. The rash took 2-3 weeks to go away. The patient thought that it was due to gardening. The patient visited a dermatologist for the management of rash and had never experienced rash in the past. The patient was prescribed with a cream (triamcinolone ointment 0.1 percent) after the second dose. The patient was put on prednisone pills after the booster. When that did not work, he got a cortisone shot from the dermatologist office.  After the Moderna vaccine, the patient described the welts as a really bad reaction. The welts took 4-5 weeks to go away.  The patient sounded very frustrated and also worried about getting the booster dose because of his condition. The patient re-iterated that he is a cancer patient and asked if the vaccine turns off tumor suppression or make the caner more aggressive.  The patient received booster shot of J and J vaccine on 23-Oct-2021 and then did not get rash.  It seemed to the patient that the reaction got worse and worse all three times. The patient was trying to keep boosted as the patient is a cancer patient, but he is fearful of getting Moderna vaccine. The patient was trying to figure out if the patient was allergic to some ingredient in the vaccine or mRNA technology. The patient reported that the steroid creams made his skin go crazy and did not really help him. The patient was strongly encouraged to speak with a healthcare provider.   This case was linked to MOD-2022-648653, MOD-2022-648659 (Patient Link).   Most recent FOLLOW-UP information incorporated above includes: On 05-Oct-2021: Follow-up received includes non-significant information. On 07-Oct-2021: FU 2 contains no new information. On 12-Oct-2021: Follow up received contains no new information On 14-Oct-2021: Follow up received contains no new information. On 21-Sep-2022: Significant follow up received includes: Events added (rash and welts), treatment medications and concomitant medications added, medical history updated and narrative updated.