she believes her husband almost went into anaphylactic shock; flu-like symptoms; fever; shivering; softball sized lump under his right arm / in the armpit; fatigue; Swelling of right arm and hand; Pain was also overlapping in the neck and spine; Pain was also overlapping in the neck and spine; pain in the right arm and hand, specially the hand / pain /in his arm and hand /; This case was reported by a physician via call center representative and described the occurrence of anaphylactic shock in a 51-year-old male patient who received Herpes zoster (Shingrix) for prophylaxis.   Previously administered products included shingrix (1st dose received on unknown date in January or February of this year.).   In June 2020, the patient received the 2nd dose of Shingrix. On 18th September 2020, less than 4 months after receiving Shingrix, the patient experienced swelling arm, neck pain, pain in spine and pain in extremity. On an unknown date, the patient experienced anaphylactic shock (serious criteria GSK medically significant), influenza-like symptoms, fever, shivering, axillary lump and fatigue. The patient was treated with prednisone. On an unknown date, the outcome of the anaphylactic shock, influenza-like symptoms, fever and shivering were unknown and the outcome of the swelling arm, neck pain, pain in spine, pain in extremity, axillary lump and fatigue were not recovered/not resolved.   It was unknown if the reporter considered the anaphylactic shock, swelling arm, neck pain, pain in spine, pain in extremity, influenza-like symptoms, fever, shivering, axillary lump and fatigue to be related to Shingrix.  Additional case details were reported as follows: The reporter was patient's wife (consumer) and physician. The patient received first Shingrix injection in January or February of this year. After first injection she stated that there were no concerns. The patient had the second dose administered at a pharmacy at an unknown date. The second injection of Shingrix was received in the first week of June but she could not remember the exact day for either injections.  The patient had developed persistent swelling of the arm and hand after the second dose of Shingrix. Patient assisted to the emergency room on 18th September 2020 due to the pain present in the hand and arm. The pain was also overlapping in the neck and spine.  The second injection he received in his right arm caused a softball sized lump under his right arm, along with pain, and swelling in his arm and hand.  The patient then attended reporter's clinic and reporter prescribed Prednisone on 20th September 2020. The reporter confirmed that patient still presented at day of report swelling and pain in the right arm and hand, specially the hand.  The patient also experienced flu-like symptoms with fever, shivering, fatigue, and pain. The reporter stated that she believes her husband almost went into anaphylactic shock. She stated that they saw the patient's (her husband) doctors but no one knew what was going on and that her husband still had fatigue, pain, swelling, and the lump under his right arm, in the armpit.  The reporter wanted to know if others had these issues. The reporter consented to follow up.; Sender's Comments:  US-GLAXOSMITHKLINE-US2020AMR206672:same patient, same reporter, 1st dose