The initial case was missing the following minimum criteria: (Unidentifiable reporter). Upon receipt of follow-up information on 06Jan2022, this case now contains all required information to be considered valid. This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP). The reporter is the patient. A 69 year-old female patient (not pregnant) received bnt162b2 (BNT162B2), administered in arm right, administration date 28Sep2021 (Lot number: 30130BA) at the age of 69 years as dose 3 (booster), single for Covid-19 immunisation. Relevant medical history included: "I'd had a very mild case of Covid-19 in Dec2020", start date: Dec2020 (unspecified if ongoing), notes: Prior to vaccination, was the patient diagnosed with COVID-19: Yes; "Hypothyroidism" (unspecified if ongoing); "Raynaud's" (unspecified if ongoing). Concomitant medication(s) included: SYNTHROID; FISH OIL; GREEN TEA EXTRACT; RED YEAST RICE. Past drug history included: Ibuprofen, reaction(s): "Known allergies: Ibuprofen". Vaccination history included: Bnt162b2 (DOSE 1, SINGLE, Batch/Lot No: EN6208 , Location of injection: Arm Right), administration date: 29Mar2021, when the patient was 68 years old, for COVID-19 immunization; Bnt162b2 (DOSE 2, SINGLE, Batch/Lot No: EW , Location of injection: Arm Right, By 13May2021 1 had a rash on my forehead), administration date: 19Apr2021, when the patient was 68 years old, for COVID-19 immunization, reaction(s): "Rash", "Hives", "swollen lips", "heartburn". The following information was reported: URTICARIA (non-serious) with onset 2021, outcome "not recovered", described as "I got the Pfizer booster on Sept 28 and now I have hives everywhere"; LIP SWELLING (non-serious) with onset 2021, outcome "not recovered", described as "swollen lips"; DYSPEPSIA (non-serious) with onset 2021, outcome "not recovered", described as "heartburn"; CONDITION AGGRAVATED (non-serious), outcome "not recovered", described as "symptoms have been worse since then". The events "I got the Pfizer booster on Sept 28 and now I have hives everywhere", "swollen lips", "heartburn" and "symptoms have been worse since then" were evaluated at the physician office visit. Therapeutic measures were taken as a result of urticaria, lip swelling, dyspepsia, condition aggravated. Additional Information: On 28Sep2021, had the booster. At the time she got the booster, she had not realized the vaccines were her problem, moved and had several other changes in their lives. At the end of September the hives were 90% gone and was down to 1/2 Allegra and 1/2 Zyrtec a day. Now she was back 2 Allegra in the morning, 2 Zyrtec and prescription antihistamine at night. So disappointed, but she would get past these hives. It was just going to take some time. She was never as completely free from hives, but they were much better by the end of Sep2021. However, she got the Pfizer booster and now had hives everywhere and back to taking lots of antihistamines. It took her getting the booster to realize the vaccine was the cause of the hives. Since then the hives have never gone completely away. These antihistamines had her napping all the time. By the end of Sep2021 the hives were much better, but still lingering. On 29Sept2021, she got the booster and the hives are back like crazy. Now she was taking lots more of the antihistamines and wondering what comes next. She had a doctor, who provided, is good advice to take liver transition, heavy mineral bugleweed formula and pure synergy superfood. The antihistamines are helping her to tolerate the hives, but not getting to the root problem which is removing from system the vaccine ingredients that gave her the hives. She was using the 3 products that are listed above and followed the directions on the labels. She was to drink a lot of water and sweat using sauna or exercise and just started using these products yesterday and her hives are half the size they were. Hopeful this will help her completely get rid of the hives, and reported that will not get anymore vaccines. As per the allergist a person can take that many antihistamines. They had never gone completely away. She got the booster and she was back to square one. All of her vaccines were Pfizer. The patient did not receive any other vaccines within 4 weeks prior to the COVID vaccine. The patient received within 2 weeks of vaccination was Synthroid, fish oil, green tea extract, red yeast. At times covered with hives, swollen lips, heartburn. Was 90% better by End of September and that was when she got the booster and symptoms have been worse since then. Prednisone 3 times, singular and non-prescription was received as treatment. Prior to vaccination, was the patient was diagnosed with COVID-19. Since the vaccination, the patient was not tested for COVID-19. No follow-up attempts are possible. No further information is expected.