She felt like she had been knocked out and weak; She felt like she had been knocked out and weak; She felt like she had been run over by a Mack truck; Anaphylactic reaction; Difficulty breathing; Swelling of the face; Swelling of throat; Blotchy rash; Palpitations of her heart; Scalp was hot; Throat was itching; This is a spontaneous report from a contactable consumer (patient).   A 52-year-old female patient (weight: 63.5 kg, height: 170 cm) received the second dose of BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE, Lot. EW0150) via an unspecified route of administration, in left arm, on 06Apr2021 at 17:00, at single dose, for COVID-19 immunization. Relevant medical history included diabetes from an unspecified date (diagnosed in early 20's. Diabetes is under control), hypertension from an unspecified date (is under control), ventricular extrasystoles described as "Early ventricular heartbeat", gallbladder disease from an unspecified date (Cholecystectomy performed on an unspecified date) and menopause from an unspecified date. She had no food allergies, no allergies at all, and had never had a reaction to another vaccine. The patient previously, on 01Mar2021, received the first dose of BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE, Lot. EN6203) via an unspecified route of administration, in left arm, at single dose, for COVID-19 immunisation. After the first dose, the patient had an anaphylactic reaction including difficulty breathing and swelling of the face and throat. She felt weird like her throat was itchy, her scalp was hot and she got blotches above her bra line up to her neck and face. The patient previously, on an unspecified date, received flu shot at single dose, for immunisation. The patient received a flu shot every year and had no problems. Concomitant medications included oral metformin hydrochloride (METFORMIN XR, tablet) 500 mg, twice daily, from an unspecified date (ongoing) for diabetes; oral diltiazem hydrochloride (DILTIAZEM XR, capsule) 24 mg, once daily, from an unspecified date (ongoing) for hypertension; oral estradiol, tablet 1 mg, once daily, from an unspecified date, in Aug2020 (ongoing) for menopause; oral methylcellulose (CITRUCEL, tablet) 1240 mg, daily, from an unspecified date (ongoing) for an unknown indication; calcium from an unspecified date for an unknown indication and colecalciferol (VITAMIN D (colecalciferol)) from an unspecified date for an unknown indication. On 06Apr2021, the patient experienced anaphylactic reaction including difficulty breathing and swelling of the face and throat. On the same date, on 06Apr2021, the patient experienced blotchy rash, palpitations of her heart, scalp was hot, and throat was itching. On 07Apr2021, she felt like she had been knocked out and weak and she felt like she had been run over by a  truck. To both doses she had an anaphylactic reaction including difficulty breathing and swelling of the face and throat. The second time the symptoms were much worse and started within 30 seconds of getting the vaccine and took Benadryl - which helped a lot. No hospitalization required. The patient recovered from anaphylactic reaction on an unspecified date, in Apr2021, while recovered from the other adverse events on 07Apr2021. She stated that she knew the vaccine works though because she was exposed to Covid by her crazy anti-vax brother and never developed Covid. Patient stated that there was an ingredient, called PEG that may be what caused her reaction.