She noticed her allergies and her immune system had calmed down the same day, she got the first shot; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP) from medical information team for a Pfizer sponsored program (159558). The reporter is the patient. A 55 year-old female patient received bnt162b2 (BNT162B2), administration date 01Apr2021 10:00 (Lot number: EW0150) at the age of 55 years as dose 1, single for covid-19 immunisation. Relevant medical history included: "immune/autoimmune disorder" (unspecified if ongoing); "allergies" (unspecified if ongoing); "Epstein-barre virus" (unspecified if ongoing); "chronic sinusitis" (unspecified if ongoing); "mixed connective tissue disease" (unspecified if ongoing); "lupus" (unspecified if ongoing); "psoriatic arthritis" (unspecified if ongoing); "fatigue" (unspecified if ongoing); "mental fog" (unspecified if ongoing); "hypersensitivity" (unspecified if ongoing). There were no concomitant medications. Vaccination history included: Hep b vaccine; Flu shot, administration date: 1993. The following information was reported: THERAPEUTIC RESPONSE UNEXPECTED (non-serious) with onset 01Apr2021, outcome "unknown", described as "She noticed her allergies and her immune system had calmed down the same day, she got the first shot". Relevant laboratory tests and procedures are available in the appropriate section.  Additional Information: The reporter stated that after she received her pfizer COVID 19 vaccine, her immune/autoimmune disorder improved or cleared up, her allergies cleared up and she wanted to report that. Reporter prefaces that she was a retired medical research post doctorate, she called herself a healthcare provider but for documentation purposes agent stated she has treated the reporter as a consumer. She said her allergies and her immune system calmed down after the vaccine. She received the first shot on 01Apr2021. She received her second dose 22Apr2021. She noticed her allergies and her immune system had calmed down the same day, she got the first shot at 10 AM in the morning. She noticed that evening, she normally has chronic sinusitis. Basically she has lupus and mixed connective tissue disease and psoriatic arthritis and autoimmune chronic sensitivities to drugs and food. She has fatigue and mental fog all the time. She clarifies at 9 that evening that the first dose was given she could breath and she didn't have allergy problems, she didn't feel fatigue, she slept soundly which is unusual for her. she usually is in a lot of pain and she noticed for the next 9 days all of her hypersensitivity and allergies were gone, she felt good, she had energy it was like she took and magical allergy pill that knocked everything out, she could breath. She said other people had the same experience. She has talked with researchers around the medical research field since COVID started in Jan2020. She has done research and been connected with former colleagues and doctors in (Country name) and (country name) and things like that have happened to other people. She has friends on twitter that are epidemiologist also have similar problems and chronic illnesses and she posted on twitter that she had this response and there must have been at least within a couple minutes, 8 people that come back and replies they had the exact same thing. No further information provided. She does not see any NDC or expiration dates on her vaccine card. She immediately kept record and let her doctor know about it she messaged him and told him she felt great this many days and that other people also confirmed that the same thing happened to them. She was surprised by the positive effect after the first shot and wished it would have lasted longer. She wants to tell her research friends that she wants a nano particle COVID vaccination to knock all of that stuff out. She was immunocompromised and she had no response with the first dose but she was very surprised on the response she had from the second dose.  Reporter Details: Probed if reporter was a physician, pharmacist or a nurse and reporter stated that she was in medical research and obtained her masters in addiction and rehabilitation housing and perused going to medical school and she was in the post- doctorate program for psychopharmacology in the late 1980s to 1990s. Later in the call she discussed how she came out of research and did clinical work at the jail. She worked in medical research, post doctorate pharmacology, forensic psych and addictions in jails. Currently she was disabled and retired. She ended up on disability related to her lupus and autoimmune issues. She clarifies she was not a pharmacist, they wanted her to go into clinical pharm D but she decided to do forensic psych instead but she still did research and published, she was addicted to research. No further details provided and no health care professional title provided from her. Probed if she would like to complete a safety report for herself and she declined and said that she has already let her physician know about the details of what she has went through and again, everything she experienced was after the second dose but it was not near as bad as when she had a flu shot in 1993. At this time, she worked with the county and got out of research and went for a title of clinical crisis forensic addiction expert in a jail for mental illnesses and substance abusers. She was trained in academies and she went into the clinic and got out of research. In 1993 her job made her have the hep B vaccine and on the third month of the hep B vaccine the county nurse kept arguing about the caller receiving the flu shot and she told the nurse that she will get the flu because she has a poor immune system and the nurse said no she wouldn't and the caller got sick of being bothered so she got it and that night she had a 107.5 fever and had the worse flu that she has ever had for 2 weeks and her immune system totally crashed and she has never had a healthy day after that and she reported this already to VAERS a while back. She didn't have a concern with the Pfizer COVID vaccine because it is an mRNA vaccine and she wasn't concerned with having another fever like she had with the flu shot, she was told not to get a flu shot ever again. She mentioned that in 1993 she had a flu shot and that night she had a 107.5 fever and had the worse flu that she has ever had for 2 weeks and her immune system totally crashed and she has never had a healthy day after that and she reported this already to VAERS a while back.  No follow-up attempts are possible. No further information is expected.