While administering Jynneos the nurse injected the air in and flipped it upside down to withdraw the vaccine, then it made a popping noise and the stopper popped out, came out of the bottle, contents fell down to the surface; Jynneos contents fell down to the surface I was working on and it splashed up into my eyes; Case reference number US-BN-2022-001785 is a spontaneous case report initially received on 04-Aug-2022 from a nurse (a patient) via Communication (reference number: USBAV22-0805) and concerns a 27-year-old female patient.  The patient's medical history and concomitant medication details were not reported. As reported, the patient was not pregnant at the time of this report.  On an unspecified date, while administering Jynneos vaccine (Smallpox and Monkeypox Vaccine, Live, Nonreplicating; batch number: unknown), the nurse injected the air in and flipped it upside down to withdraw the vaccine, then it made a popping noise and the stopper popped out, came out of the bottle (explicitly coded as 'product stopper coring'), contents fell down to the surface the nurse was working on and it splashed up into her eyes (explicitly coded as 'occupational exposure to product via eye'). As reported, the nurse washed out her eyes.  It was not reported if the patient experienced any adverse event due to Jynneos vaccine.  This case is linked with case US-BN-2022-001784 due to the same reporter.  Additional information received on 08-Aug-2022 included the local case ID and PQC reference number (QE-001831).; Reporter's Comments: In this case the nurse injected the air in and flipped it upside down to withdraw the vaccine, then it made a popping noise and the stopper popped out, came out of the bottle which is considered as product stopper coring. Contents fell down to the surface the nurse was working on and it splashed up into her eyes which is considered as occupational exposure to product via eye. Reportedly, the nurse washed out her eyes. Occupational exposure to product and product closure issue are both considered listed per company conventions. At this point, it was not reported if the patient experienced any adverse event due to Jynneos vaccine. The patient's medical history and concomitant medication details were not reported and the patient was not pregnant at the time of this report. Causality is assessed as not related to suspect product but to human factor. The case is non-serious.; Sender's Comments: In this case the nurse injected the air in and flipped it upside down to withdraw the vaccine, then it made a popping noise and the stopper popped out, came out of the bottle which is considered as product stopper coring. Contents fell down to the surface the nurse was working on and it splashed up into her eyes which is considered as occupational exposure to product via eye. Reportedly, the nurse washed out her eyes. Occupational exposure to product and product closure issue are both considered listed per company conventions. At this point, it was not reported if the patient experienced any adverse event due to Jynneos vaccine. The patient's medical history and concomitant medication details were not reported and the patient was not pregnant at the time of this report. Causality is assessed as not related to suspect product but to human factor. The case is non-serious.