Covid arm in opposite arm; high fever; Local itching/pruritus; local redness/erythema; local rash; This spontaneous case was reported by a consumer and describes the occurrence of PAIN IN EXTREMITY (Covid arm in opposite arm), PRURITUS (Local itching/pruritus), ERYTHEMA (local redness/erythema), RASH (local rash) and PYREXIA (high fever) in a 53-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 29A21A and 002A21A) for COVID-19 vaccination.     Previously administered products included for Product used for unknown indication: shingrix (patient received a non Moderna inactivated vaccine.  She experienced something very similar to Covid reaction). Past adverse reactions to the above products included Adverse drug reaction with shingrix. Concurrent medical conditions included Asthma, Hay fever, Hives, Bee sting (experienced Moderate generalized reaction) since 07-Jan-1980, Penicillin allergy (experienced Hives, trouble breathing), Drug allergy (Allergic to Codeine  Experienced Nausea, vomiting, dizziness) since 04-Aug-1990, Drug allergy (Allergic to Hydrocodone  experienced Nausea, vomiting, dizziness), Hypothyroidism since 15-Jul-2013 and Osteoporosis on 15-Oct-2018. Concomitant products included LEVOTHYROXINE SODIUM (SYNTHROID) from 2021 to an unknown date, CALCIUM CARBONATE, COLECALCIFEROL (CALCIUM & VITAMIN D3), MAGNESIUM MALATE, ZINC GLYCINATE (MAGNESIUM + ZINK), GABAPENTIN, TRAZODONE HCL from 2017 to an unknown date and BUPROPION HYDROCHLORIDE (BUPROPION HCL XL) for an unknown indication.   On 26-Feb-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 26-Mar-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 05-Mar-2021, the patient experienced PRURITUS (Local itching/pruritus), ERYTHEMA (local redness/erythema) and RASH (local rash). On an unknown date, the patient experienced PAIN IN EXTREMITY (Covid arm in opposite arm) and PYREXIA (high fever). The patient was treated with DIPHENHYDRAMINE HYDROCHLORIDE (BENADRYL A) (oral) from 09-Mar-2021 to 13-Mar-2021 at a dose of 50 milligram twice a day. On 16-Mar-2021, PRURITUS (Local itching/pruritus), ERYTHEMA (local redness/erythema) and RASH (local rash) had resolved. At the time of the report, PAIN IN EXTREMITY (Covid arm in opposite arm) and PYREXIA (high fever) outcome was unknown.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On an unknown date, Body temperature: 102.3 (High) 102.3 for 1 day, 100 (Inconclusive) 100- second day and 101 (Inconclusive) 101- second day.         Treatment medication also include other- Topical 2-3 times per day  Action taken with mRNA-1273  Moderna vaccine was Not applicable   This case was linked to US-MODERNATX, INC.-MOD-2021-037515, MOD21-047239 (E2B Linked Report).   Most recent FOLLOW-UP information incorporated above includes: On 08-Jun-2021: Follow up received on 8-JUN-2021: Included address, Height, weight, race, ethnicity was updated. Medical history, lab data was added. Dose details, Concomitant, treatment medications, new events were added. Events outcome was updated.; Sender's Comments:  US-MODERNATX, INC.-MOD-2021-037515:1st dose case MOD21-047239: