DIFFICULTY IN STANDING; SHARP MUSCLE PAIN; SEVERE PAIN IN HER HANDS IN SHOULDER; PAIN; SORENESS; MUSCLES ITCHED; FELT LIKE PINS AND NEEDLES; CRYING; JOINTS STIFF; This spontaneous report received from a patient concerned a 60 year old female, race and ethnicity not reported. Initial information was received on 12-JUN-2021 and processed with additional information received on 14-JUN-2021 via telephone call log.  The patient's height, and weight were not reported. The patient's concurrent conditions included rheumatoid arthritis diagnosed approximately 15 years ago, thyroid issues, Addison's disease diagnosed approximately 15 years ago, fibromyalgia diagnosed approximately 15 years ago, bursitis, Gaucher diagnosed approximately 15 years ago, and myositis. The patient received covid-19 vaccine ad26.cov2.s (suspension for injection, intramuscular, batch number: Unknown) dose was not reported, administered on approximately 04-MAY-2021 for prophylactic vaccination. The batch number was not reported and has been requested. Concomitant medications included diclofenac, gabapentin, hydroxychloroquine, hydroxyzine hydrochloride, levothyroxine, morphine, pravastatin, and valproate semisodium. The patient reported that approximately 1-1.5 weeks after the vaccine, she had a very sharp muscle pain and a 'pins and needles' feeling in them. Approximately two weeks post vaccine, she had severe pain in her hands in shoulders. Additionally patient reported that within a day, she started getting very sore arm, shoulder, shoulder blade, elbow, and hand on the arm where the vaccine was given. The patient thought the pain would go away with little time. The patient used ice, heat, and various lotions trying to combat the pain. The patient reported that after several weeks, she was in so much pain, she could not stand it. Her muscles itched, felts like pins and needles were attacking them. The patient sat and cried. She reported that her joints started reacting to the vaccine. Joints would lock up and sometimes would be so stiff and locked, that she couldn't get them to move. The patient sat in one position for hours until she could get them unlock and moved. The patient reported being to several doctors and they don't know what to do. The patient saw a doctor on 18-MAY-2021 and reported that 'he was of no use' and had 'no clue what to do'. Physician ordered full bloodwork for her and results were 'normal'. The patient tried to access lab records but she said they 'had been deleted already'. The patient is currently experiencing pain in hip, shoulder, and hands. The patient reported that the pain was better now than it was when it began after taking the vaccine. The patient's vision and balance were normal. She did not experience any unusual/prolonged bleeding or bruising since receiving vaccine. The patient reported that she never experienced painful events prior to receiving vaccine.  The action taken with covid-19 vaccine ad26.cov2.s was not applicable. The patient was recovering from sharp muscle pain, severe pain in her hands in shoulder, and pain. The outcome of the soreness,  difficulty in standing, muscles itched, crying, joints stiff, and felt like pins and needles was not reported. This report was serious (Other Medically Important Condition).; Sender's Comments: V0: This spontaneous report received from a patient concerned a 60-year-old woman who experienced sharp muscle pains, soreness, stiff joins, and "pins and needles" 1-2 weeks after vaccine.  Medical history included rheumatoid arthritis, thyroid issues, Addison's disease, fibromyalgia, bursitis, Gaucher disease, and myositis. Concomitant medications included diclofenac, gabapentin, hydroxychloroquine, hydroxyzine hydrochloride, levothyroxine, morphine, pravastatin, and valproate. The patient reported that approximately 1-1.5 weeks after the vaccine, she had a very sharp muscle pain and a 'pins and needles' feeling in them. Approximately two weeks post vaccine, she had severe pain in her hands in shoulders. The patient used ice, heat, and various lotions trying to combat the pain. Her muscles itched. The patient sat and cried. She reported that her joints started reacting to the vaccine. The patient reported being to several doctors and they don't know what to do. The patient saw a doctor and reported that 'he was of no use' and had 'no clue what to do'. Physician ordered full bloodwork for her and results were 'normal'. The patient reported that the pain was better now than it was when it began after taking the vaccine. The patient's vision and balance were normal. She did not experience any unusual/prolonged bleeding or bruising since receiving vaccine. She is recovering. Given a multitude of symptoms without a clear diagnosis, and a complicated underlying medical history, there may be alternate etiology for her pain and symptoms. However, given the temporal relationship, a relationship with vaccine can not be entirely excluded.