swelling in both of his hands/the first shot, the thumb swelled and then with the second shot; he had pain/Pain of the hands on the scale of 1 to 10 is a 3 or 4; half of his face is swollen; This is a spontaneous report received from a contactable consumer (patient wife). A 71-year-old male patient received bnt162b2 (PFIZER-BIONTECH COVID-19 VACCINE, formulation: solution for injection, Batch/Lot Number: EL9266 and expiry date was not reported) via an unspecified route of administration, administered in Arm Left on 12Feb2021 (age at vaccination 70-years-old) as dose 2, single for covid-19 immunization and colchicine taken for arthritis on an unspecified date. The patient historical vaccine includes bnt162b2 (PFIZER-BIONTECH COVID-19 VACCINE, formulation: solution for injection, Batch/Lot Number: EL9262and expiry date was not reported) via an unspecified route of administration, administered in Arm Left on 22Jan2021 (age at vaccination 70-year-old) as dose 1, single for covid-19 immunization. The patient medical history included kidney problem. Concomitant medications were not reported.   Reported and her husband, name, took his last COVID-19 Vaccine dose on 12Feb2021. She said the next week her husband had swelling in both of his hands. Following week, his hand swelling got worse, and he had pain with the hand swelling. The third week, her husband went to a doctor at a place where he could get an appointment the same day. She said that doctor did tests on her husband for Rheumatoid Arthritis and Bursitis, and both tests were negative. She said that doctor gave her husband Prednisone to take. She said when her husband took the Prednisone, his hand swelling went down for 3-4 days. She said when her husband stopped the Prednisone, the swelling in his hands came back. She said her husband then went to his primary care doctor. She said her husband's primary care doctor gave him more lab tests, and did another Rheumatoid Arthritis test, which was negative. She said her husband's primary care doctor gave her husband some Rheumatoid Arthritis medicine to take, but her husband stopped taking the medicine after 2 days. She said her husband had a history of kidney problems. She said her husband continued to have hand swelling, so she took her husband to the Emergency Room. She said the Emergency Room doctor did an ANA test that was inconclusive, and an ESR test that was negative. Emergency Room doctor gave her husband more Prednisone to take. She said when her husband took the Prednisone, and his hand swelling went down, again. She said when her husband finished taking he Prednisone, his hand swelling came back. She said her husband had more tests done with his primary care doctor, and all the tests were negative. Her husband's arms started to be effected by the swelling, so she took her husband back to the Emergency Room. She said now her husband had to go to a Rheumatoid Arthritis specialist. This morning her husband woke up, and half of his face was swollen.   Her husband is having, she believed a reaction to the vaccine (confirmed as Pfizer COVID Vaccine). Over the past few weeks, he is having hands, both hands swollen. He's had test for rheumatoid arthritis and ANA and several other things coming out negative for the first week, 2 week, 3 week, last week one of the test came up inconclusive, they are giving him Prednisone that's taken the swelling down and referring him to rheumatoid specialist but they are saying also that it could be reaction to vaccine. Now today half of his face is swollen. He has not gotten to the rheumatoid specialist but half of the face is swollen now and so we are wondering what we should do at this point. He was in a lot of pain, the pain of the hands on the scale of 1 to 10 is a 3 or 4 and when he took the Prednisone (treatment), it goes down and just a little or no pain. Then with the swelling of the face right now there is no pain. When probed for other treatment, reporter stated, He did took, he only took it twice because they told him not to take it anymore. So, they repeated that (Colchicine) if it was arthritis then it would help and it would go down but it did not and they told him to stop taking it.   The patient underwent lab tests and procedures which included antinuclear antibody and result was inconclusive, laboratory test result was negative, doctor gave him more lab tests, pain assessment: 3 or 4 on 2021, red blood cell sedimentation rate result was negative, rheumatoid arthritis and bursitis result was negative in 2021. Outcome of the events was recovered with sequel.   No follow-up attempts are needed. No further information is expected.