Her feet turned into giant whelps; Hives/hives started out on her feet and arms, and now they are taking over her entire body; She was having a hard time walking; They are painful; This is a spontaneous report received from a contactable consumer (patient herself). A 45-year-old female patient received second dose BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE), intramuscular, administered in Arm Left on 30Mar2021 09:00 (Lot Number: ER8733, at age of 45 years old) as single dose for COVID-19 immunisation. Medical history included she had always had bad allergies. She thought it was just an immune, Compromised immune status, Respiratory illness, Chromosomal abnormalities, diabetes, obesity, Seasonal allergies diagnosed when she was 5 years old, interstitial cystitis diagnosed a few years ago. The patient's concomitant medications were not reported. The patient previously Intramuscularly received first dose of BNT162B2 on 09Mar2021 for Covid-19 immunization, lot: EN6206; anatomical location: Left arm; Time the vaccination was given: 09:00. The patient developed hives on 07Apr2021, 5 days after receiving the second dose of the Pfizer Covid 19 vaccine. They had been going on for 6 weeks and weren't going away despite being on prednisone. Her doctor said there was no life threatening issue. She said they were painful, annoying and she couldn't work out or participate with her family like she wanted. She developed hives and was put on 60 mg of Prednisone to control. They started 5 days after the second dose of the vaccine and have not gone away. There was no prescriber. Her family recommended she did something. She would be seeing an allergist. She said Prednisone was a hell of a drug to be on. After second dose, she was told to do light exercise to move her arm. She did not have any fatigue. She was working out and 5 days later, she got the hives. The hives started out on her feet and arms, and now they were taking over her entire body. She was having a hard time walking because the ones in her feet turned into giant whelps. She could not put on shoes. She had to go to the ER to try and control them. She was already on Prednisone and her time was up and they came back worse. They put her back on it. She might have to take a pill for the rest of her life. They were not going away. The first Prednisone was 20mg and she was taking it twice daily for 5 days. She did not have a lot or expiration as she had disposed of it and it was in a pharmacy vial. The start date of the current Prednisone was 02May2021. The current dose was 10mg. She was taking it 6 times a day and was now taking twice a day. It was in a pharmacy vial with no lot or expiration. The count size of the 20 mg was unknown. The count size of the 10 mg is 57. She would not be willing to send a sample. ER or physician's office required at the Urgent Care. She went to that urgent care twice. The first time they said to ride it out. The second time, they prescribed Prednisone. She finished it and was on vacation and got them again. She had to go to the ER to get more Prednisone because they covered her entire body. It was very scary to have a new thing and thinking body was attacking itself. The outcome of hives giant and hives was not recovered, the outcome of rest events was unknown.  Information on Lot/Batch number was available. Additional information had been requested.