wrist and hand started swelling; hand started swelling/hand looked swollen/couldn't touch thumb and middle finger around the other wrist (almost 1 inch gap); felt weird because they were filled with fluid; slightly itchy/it turned into large pink splotches that were pretty itchy/itchy and red in one spot and then another spot/itchiness on various places; hives got way worse, like super super itchy all over her arms and neck and pretty painful; hives on the back of both legs/happened on both arms as well/white hives/hives got way worse; large pink splotches; skin is still more sensitive than it usually is; red in one spot and then another spot/It was a red circle around the injection site about 3 inches across; patient was still getting heat on various places; This spontaneous case was reported by a consumer and describes the occurrence of URTICARIA (hives on the back of both legs/happened on both arms as well/white hives/hives got way worse), SKIN DISCOLOURATION (large pink splotches), PRURITUS (slightly itchy/it turned into large pink splotches that were pretty itchy/itchy and red in one spot and then another spot/itchiness on various places), RASH (hives got way worse, like super super itchy all over her arms and neck and pretty painful) and JOINT SWELLING (wrist and hand started swelling) in a 28-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 034F21A, 007C21A and 039A21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     No Medical History information was reported.   On 03-Apr-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 04-May-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 10-Nov-2021, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. In November 2021, the patient experienced RASH ERYTHEMATOUS (red in one spot and then another spot/It was a red circle around the injection site about 3 inches across) and FEELING HOT (patient was still getting heat on various places). On 19-Nov-2021, the patient experienced URTICARIA (hives on the back of both legs/happened on both arms as well/white hives/hives got way worse), SKIN DISCOLOURATION (large pink splotches) and SENSITIVE SKIN (skin is still more sensitive than it usually is). On 20-Nov-2021, the patient experienced PRURITUS (slightly itchy/it turned into large pink splotches that were pretty itchy/itchy and red in one spot and then another spot/itchiness on various places) and RASH (hives got way worse, like super super itchy all over her arms and neck and pretty painful). On 22-Nov-2021, the patient experienced JOINT SWELLING (wrist and hand started swelling), PERIPHERAL SWELLING (hand started swelling/hand looked swollen/couldn't touch thumb and middle finger around the other wrist (almost 1 inch gap)) and BLISTER (felt weird because they were filled with fluid). The patient was treated with CETIRIZINE HYDROCHLORIDE (ZYRTEC [CETIRIZINE HYDROCHLORIDE]) for Hives and Itchy, at an unspecified dose and frequency and FEXOFENADINE on 25-Nov-2021 for Adverse event, at an unspecified dose and frequency. On 03-Dec-2021, URTICARIA (hives on the back of both legs/happened on both arms as well/white hives/hives got way worse), PRURITUS (slightly itchy/it turned into large pink splotches that were pretty itchy/itchy and red in one spot and then another spot/itchiness on various places), RASH ERYTHEMATOUS (red in one spot and then another spot/It was a red circle around the injection site about 3 inches across) and FEELING HOT (patient was still getting heat on various places) had resolved. At the time of the report, SKIN DISCOLOURATION (large pink splotches) and RASH (hives got way worse, like super super itchy all over her arms and neck and pretty painful) outcome was unknown, JOINT SWELLING (wrist and hand started swelling), PERIPHERAL SWELLING (hand started swelling/hand looked swollen/couldn't touch thumb and middle finger around the other wrist (almost 1 inch gap)) and BLISTER (felt weird because they were filled with fluid) was resolving and SENSITIVE SKIN (skin is still more sensitive than it usually is) had not resolved.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On 23-Nov-2021, Blood pressure measurement: 130+ (High) really high (it was usually 90s). On 23-Nov-2021, Heart rate: 120 (High) high like 120s.         Concomitant medication information was not provided by the reporter.                            On 23-Nov-2021, the emergency room provided the patient with an antihistamine injection. The patient experienced a delayed reaction of symptoms to the third dose.  The hives got way worse, like super itchy all over the patient's arms, hips and neck and were pretty painful. Some of the hives became red and splotchy and would look like tiny mosquito bites, but others would be big and raised, like on the upper back.   This case was linked to MOD-2021-406260 (Patient Link).