2 days later the patient complained of major swelling of all cheeks and lips area; 2 days later the patient complained of major swelling of all cheeks and lips area; all the face [was] with big lumps on NL, Lip1 upper lower and C8; A day later, patient presented swelling on all mid lower face mostly on lips, NL and C6. Patient did not attend the clinic and a day later, patient presented worsening.; This is spontaneous report from a Non-contactable HCP. This HCP reported for a patient that: A patient of unspecified age and gender received bnt162b2 (PFIZER BIONTECH COVID-19 mRNA VACCINE; Solution for injection; Lot number: Unknown), via an unspecified route of administration as dose number unknown, single on Jan2021 for covid-19 immunisation. Medical history included mass, lip swelling, hypoaesthesia, injection site mass and injection site swelling all from an unknown date and unknown if ongoing. Concomitant medications included lidocaine hydrochloride (LIDOCAINE HYDROCHLORIDE); hyaluronic acid (HYALURONIC ACID); hyaluronic acid (JUVEDERM; prednisone (PREDNISONE) at 40mg; ciprofloxacin (CIPROFLOXACIN) at 750mg per day and azithromycin (AZITHROMYCIN) at 500mg a day all taken for an unspecified indication, start and stop date were not reported. As per reporter, the patient injected with 1ml of Juvederm (VOLIFT) with Lidocaine in the NL23, Lip1 and C6, 2ml of Juvederm (VOLUX) in JW1, JW4/5 and C2 and 1ml of Juvederm (VOLITE) in Lip8 and CK5. The result was excellent, satisfaction level high. Two months later, patient started to feel a lump in JW4 left side. Two weeks later patient attended the clinic for a review and HCP injected HAYALSE 200U to the area. Reporter felt mild degradation and prescribed Prednisone 40mg for 5 days and Ciprofloxacin 750mg per day for 14 days. Healthcare professional (HCP) advised, the lump got smaller but was still prominent 48 hours after injection. Two days later, patient felt better and continued with the prescribed medication Prednisone for 3 days. One week later, patient presented swelling all around the lips and NL area and numbness at the NL area and nose area. Two days later, patient presented, worsening on swelling and lumps on injection areas mainly NL and lips. Patient took 40mg of Prednisone and felt better after 6 hours. After consultation HCP decided to stop with Ciprofloxacin and start Azithromycin at 500mg a day for 2 days and then 250mg for 3 more days till the next consultation. In early Jan2021, the patient received the first COVID-19 PFIZER vaccination. A day later, patient presented with swelling on all mid lower face - mostly on lips, NL and C6 (On unspecified date in 2021). Patient did not attend the clinic and a day later, patient presented got worsened. Patient attended ER for blood tests and treatment and received IV of Hydrocort 250mg. A day later, the patient showed no recovery and started to take Fexofenadine 180mg twice a day. Patient attended clinic the following day and HCP noted, all the face was with big lumps on NL, Lip1 upper lower and C8. HCP injected HAYALASE 1000U and felt a small improvement while massaging the areas. The patient started Augmentin 875mg twice a day, along with Fexofenadine. A few days later, patient received another injection of HAYALASE 1000U to the remaining stubborn lumps on same areas. HCP noted, improvement on swelling, but prominent lumps. Patient received another injection of HAYALASE 500U. HCP noted, improvement with smaller lumps remnant -no major degradation. HCP advised, the patient satisfaction rate for 2 months after the treatment was extremely high. Patient was frustrated obviously and want to get rid of the lumps. HCP further advised, the feeling in the tissue was a hard capsulation of the filler with minimum ability to degrade with HAYALASE. The patient improved dramatically but still with small lumps on all C8, Lips -focused and NL3. This record captures events relating to the Juvederm (Volite) injection. The patient underwent lab tests and procedures which included blood test: unknown on unspecified date. Therapeutic measures were taken as a result of the events. The outcome of event condition worsened was unknown and rest all were recovering.  No follow-up attempts are possible. No further information.