I tested positive (home antigen and PCR) on Monday 18Apr. On Tuesday 19Apr I started taking Paxlovid. After completing the 5 days of Paxlovid, i tested positive on a home antigen test.; I tested positive (home antigen and PCR) on Monday 18Apr. On Tuesday 19Apr I started taking Paxlovid. After completing the 5 days of Paxlovid, i tested positive on a home antigen test; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP). The reporter is the patient.  A 52-year-old male patient received BNT162b2 (BNT162B2), on 05Nov2021 as dose 3 (booster), single (Lot number: F178020) at the age of 52 years, in left arm for covid-19 immunisation; coviD-19 vaccine mrna (mrna 1273) (MODERNA COVID-19 VACCINE), on 10Mar2021 as dose 1, single (Lot number: 004M20A), in left arm and on 07Apr2021 as dose 2, single (Lot number: 003A21A), in left arm for covid-19 immunisation. The patient's relevant medical history included: "Overweight" (unspecified if ongoing); "Spring allergies" (unspecified if ongoing); "modest food allergies" (unspecified if ongoing). Concomitant medication(s) included: ALLEGRA, start date: 17Apr2022, stop date: 04May2022; FLONASE [FLUTICASONE PROPIONATE], start date: 17Apr2022, stop date: 04May2022; TYLENOL, start date: 18Apr2022, stop date: 21Apr2022. The following information was reported: COVID-19 (medically significant) with onset 18Apr2022, outcome "unknown", described as "I tested positive (home antigen and PCR) on Monday 18Apr. On Tuesday 19Apr I started taking Paxlovid. After completing the 5 days of Paxlovid, i tested positive on a home antigen test"; DRUG INEFFECTIVE (medically significant) with onset 18Apr2022, outcome "unknown", described as "I tested positive (home antigen and PCR) on Monday 18Apr. On Tuesday 19Apr I started taking Paxlovid. After completing the 5 days of Paxlovid, i tested positive on a home antigen test.". The patient underwent the following laboratory tests and procedures: Polymerase chain reaction: (18Apr2022) Positive, notes: I tested positive on a home antigen test; (03May2022) Negative, notes: On day 10 post infection, i tested negative on a home antigen test; SARS-CoV-2 test: (unspecified date) Positive, notes: On days 11, 12, 13, 14 , 15 & 16 post infection, I've tested positive on home antigen tests and my symptoms have returned, although not as severely as with my initial symptoms (no fever, chills, night sweats, but consistent cough and congestion and every afternoon/evening a run down and tired feeling); (24Apr2022) Positive, notes: After completing the 5 days of Paxlovid, i tested positive on a home antigen test. Therapeutic measures were taken as a result of drug ineffective, covid-19. Clinical course: It was reported that the patient tested positive (home antigen and PCR) on Monday 18Apr. On Tuesday 19Apr2022 he started taking Paxlovid (Start date: 19Apr2022, Stop date: 24Apr2022, Lot number: FX2740, Indication: Treatment of COVID-19). After completing the 5 days of Paxlovid, he tested positive on a home antigen test. Although he felt much better (his fever was gone and his cough and congestion reduced). On day 10 post infection, he tested negative on a home antigen test. On days 11, 12, 13, 14, 15 & 16 post infection, he had tested positive on home antigen tests and his symptoms have returned, although not as severely as with his initial symptoms (no fever, chills, night sweats, but consistent cough and congestion and every afternoon/evening a run down and tired feeling).  No follow-up attempts are possible. No further information is expected.