A year-round of hearth problems; Vertigo; Cannot bend over or look up; Uterus was 6 times bigger than normal; Prolapse; Fibroids; inflammation of her left breast; pain; Gastrointestinal problems; Major constipation; Dizziness; Armpit hurts; Swelling of the lymph nodes in her armpit and neck; She also had an inflammation of the lymph nodes on her face on the left side; 4 types Arrhythmias (PAC, PVC, SVT and VTac); 50% right coronary blockage related with inflammation; Quivering in arteries; High Blood Pressure; Shortness of breath; 50% right coronary blockage related with inflammation, Inflammation in the cartilage between her ribs.; This spontaneous case was reported by a patient and describes the occurrence of ARRHYTHMIA (4 types Arrhythmias (PAC, PVC, SVT and VTac)), CORONARY ARTERY OCCLUSION (50% right coronary blockage related with inflammation) and ARTERIOSPASM CORONARY (Quivering in arteries) in a 48-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch no. 066F21A) for COVID-19 prophylaxis. The occurrence of additional non-serious events is detailed below.     Concomitant products included METOPROLOL for Arrhythmia and Shortness of breath, LOSARTAN for Blood pressure high, CARISOPRODOL (MIO RELAX [CARISOPRODOL]), SODIUM PICOSULFATE (DULCOLAX [SODIUM PICOSULFATE]) and SENNOSIDE A+B (SENOKOT) for Constipation.    On 04-Nov-2021, the patient received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 04-Dec-2021, the patient experienced ARRHYTHMIA (4 types Arrhythmias (PAC, PVC, SVT and VTac)) (seriousness criterion medically significant), CORONARY ARTERY OCCLUSION (50% right coronary blockage related with inflammation) (seriousness criterion medically significant), ARTERIOSPASM CORONARY (Quivering in arteries) (seriousness criterion medically significant), HYPERTENSION (High Blood Pressure), DYSPNOEA (Shortness of breath) and INFLAMMATION (50% right coronary blockage related with inflammation, Inflammation in the cartilage between her ribs.). On an unknown date, the patient experienced CARDIAC DISORDER (A year-round of hearth problems), VERTIGO (Vertigo), MOBILITY DECREASED (Cannot bend over or look up), UTERINE ENLARGEMENT (Uterus was 6 times bigger than normal), PROLAPSE (Prolapse), UTERINE LEIOMYOMA (Fibroids), BREAST INFLAMMATION (inflammation of her left breast), PAIN (pain), GASTROINTESTINAL DISORDER (Gastrointestinal problems), CONSTIPATION (Major constipation), DIZZINESS (Dizziness), AXILLARY PAIN (Armpit hurts), LYMPHADENOPATHY (Swelling of the lymph nodes in her armpit and neck) and LYMPHADENITIS (She also had an inflammation of the lymph nodes on her face on the left side). The patient was treated with DOXYCYCLINE for Pain, at an unspecified dose and frequency. At the time of the report, ARRHYTHMIA (4 types Arrhythmias (PAC, PVC, SVT and VTac)), ARTERIOSPASM CORONARY (Quivering in arteries), HYPERTENSION (High Blood Pressure), DYSPNOEA (Shortness of breath), INFLAMMATION (50% right coronary blockage related with inflammation, Inflammation in the cartilage between her ribs.), CARDIAC DISORDER (A year-round of hearth problems), VERTIGO (Vertigo), MOBILITY DECREASED (Cannot bend over or look up) and DIZZINESS (Dizziness) had not resolved and CORONARY ARTERY OCCLUSION (50% right coronary blockage related with inflammation), UTERINE ENLARGEMENT (Uterus was 6 times bigger than normal), PROLAPSE (Prolapse), UTERINE LEIOMYOMA (Fibroids), BREAST INFLAMMATION (inflammation of her left breast), PAIN (pain), GASTROINTESTINAL DISORDER (Gastrointestinal problems), CONSTIPATION (Major constipation), AXILLARY PAIN (Armpit hurts), LYMPHADENOPATHY (Swelling of the lymph nodes in her armpit and neck) and LYMPHADENITIS (She also had an inflammation of the lymph nodes on her face on the left side) outcome was unknown.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On 04-Dec-2021, Blood pressure measurement: High. On an unknown date, Enzyme level test: Elevated. On an unknown date, Lipids: Elevated. On an unknown date, Mammogram: Inflammation in the cartilage between ribs.. On an unknown date, White blood cell count: Elevated.     For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown), the reporter did not provide any causality assessments.   Did a stress test, echocardiogram and arteriogram. He said this blockage was not due to build up in the artery. A lipid control specialist who gave her 2 medications and is about to give her a 3rd one.  Also, after the booster she had perimenopausal ultrasound and had to perform a hysterectomy. Performed the surgery on 17Aug2022. Uterus weighted 300 grams instead of 60 grams.  Patient had no myocarditis or pericarditis previously and also never tested positive for COVID 19: No  Company Comment: This is a spontaneous case concerning a 48-year-old female patient with no reported medical history, who experienced the unexpected, serious (medically significant) adverse event of special interest of Arrhythmia and the unexpected, serious (medically significant) events of Coronary artery occlusion and Arteriospasm coronary, 30 days after receiving the third dose of mRNA-1273 vaccine. The patient developed shortness of breath and underwent stress test, echocardiogram and arteriogram which showed 4 different types of Arrhythmias (PAC, PVC, SVT and VTac), quivering of arteries and 50% right coronary blockage. The patient was treated with Metoprolol and medications for lipid control. The outcome of the events unknown at the time of the report. The benefit-risk relationship of mRNA-1273 is not affected by this report.   This case was linked to MOD-2022-649984, MOD-2022-649986 (Patient Link). Sender's Comments: This is a spontaneous case concerning a 48-year-old female patient with no reported medical history, who experienced the unexpected, serious (medically significant) adverse event of special interest of Arrhythmia and the unexpected, serious (medically significant) events of Coronary artery occlusion and Arteriospasm coronary, 30 days after receiving the third dose of mRNA-1273 vaccine. The patient developed shortness of breath and underwent stress test, echocardiogram and arteriogram which showed 4 different types of Arrhythmias (PAC, PVC, SVT and VTac), quivering of arteries and 50% right coronary blockage. The patient was treated with Metoprolol and medications for lipid control. The outcome of the events unknown at the time of the report. The benefit-risk relationship of mRNA-1273 is not affected by this report.