Raised circular areas on knucle; Wrist itch; stiff body/Stiff walking; Right hip discomfort; Pimples on third finger; Teeth sore with pressure; Teeth sore with pressure; Neck pain; hands hot to touch; Cannot drive/cannot touch fingers to palm; Stiff joint; Fingers still heavy/Discomfort in middle finger, hand and L hand; Pins and needles/both the hands and not all fingers; site of injection hurts; Occaissional chills; Fever/intermettent fever upto 100.8 F; L shoulder sore/elbow pain/both shouders hurt; Feet starting to break out in rash/Rash on fingers and wrists/rash on both hands upto knuckles; It is very painful/severe pain all fingers and left arm; Severe swelling of arm and shoulder on down to her hands/hands welling and whole hands and fingers swollen/R hand bubbles little smaller; Red rashes everywhere; This spontaneous case was reported by a nurse and describes the occurrence of PERIPHERAL SWELLING (Severe swelling of arm and shoulder on down to her hands/hands welling and whole hands and fingers swollen/R hand bubbles little smaller), RASH ERYTHEMATOUS (Red rashes everywhere), SWELLING (Raised circular areas on knucle), PRURITUS (Wrist itch) and MUSCULOSKELETAL STIFFNESS (stiff body/Stiff walking) in a 79-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch no. 011A21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     The patient's past medical history included Asthma. Concurrent medical conditions included Drug allergy (allergy to mefloquine).    On 04-Mar-2021, the patient received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 14-Mar-2021, the patient experienced PERIPHERAL SWELLING (Severe swelling of arm and shoulder on down to her hands/hands welling and whole hands and fingers swollen/R hand bubbles little smaller), RASH ERYTHEMATOUS (Red rashes everywhere) and MYALGIA (It is very painful/severe pain all fingers and left arm). On 16-Mar-2021, the patient experienced RASH (Feet starting to break out in rash/Rash on fingers and wrists/rash on both hands upto knuckles). On an unknown date, the patient experienced SWELLING (Raised circular areas on knucle), PRURITUS (Wrist itch), MUSCULOSKELETAL STIFFNESS (stiff body/Stiff walking), MUSCULOSKELETAL DISCOMFORT (Right hip discomfort), ACNE (Pimples on third finger), TOOTHACHE (Teeth sore with pressure), DENTAL DISCOMFORT (Teeth sore with pressure), NECK PAIN (Neck pain), FEELING HOT (hands hot to touch), LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (Cannot drive/cannot touch fingers to palm), JOINT STIFFNESS (Stiff joint), LIMB DISCOMFORT (Fingers still heavy/Discomfort in middle finger, hand and L hand), PARAESTHESIA (Pins and needles/both the hands and not all fingers), VACCINATION SITE PAIN (site of injection hurts), CHILLS (Occaissional chills), PYREXIA (Fever/intermettent fever upto 100.8 F) and ARTHRALGIA (L shoulder sore/elbow pain/both shouders hurt). At the time of the report, PERIPHERAL SWELLING (Severe swelling of arm and shoulder on down to her hands/hands welling and whole hands and fingers swollen/R hand bubbles little smaller), RASH ERYTHEMATOUS (Red rashes everywhere), SWELLING (Raised circular areas on knucle), PRURITUS (Wrist itch), MUSCULOSKELETAL STIFFNESS (stiff body/Stiff walking), MUSCULOSKELETAL DISCOMFORT (Right hip discomfort), ACNE (Pimples on third finger), TOOTHACHE (Teeth sore with pressure), DENTAL DISCOMFORT (Teeth sore with pressure), NECK PAIN (Neck pain), FEELING HOT (hands hot to touch), LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (Cannot drive/cannot touch fingers to palm), JOINT STIFFNESS (Stiff joint), LIMB DISCOMFORT (Fingers still heavy/Discomfort in middle finger, hand and L hand), PARAESTHESIA (Pins and needles/both the hands and not all fingers), RASH (Feet starting to break out in rash/Rash on fingers and wrists/rash on both hands upto knuckles), MYALGIA (It is very painful/severe pain all fingers and left arm), VACCINATION SITE PAIN (site of injection hurts), CHILLS (Occaissional chills), PYREXIA (Fever/intermettent fever upto 100.8 F) and ARTHRALGIA (L shoulder sore/elbow pain/both shouders hurt) outcome was unknown.        For mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular), the reporter did not provide any causality assessments.   Patient went to ER & was prescribed 5 day course of steroid.  No concomitant medication is reported.   Most recent FOLLOW-UP information incorporated above includes: On 18-Jul-2021: Significant follow-up received and relevant history provided. On 18-Jul-2021: Follow-up received and contain non-significant information.