Vomiting; Had a procedure performed by a HCP to pop five styes on her upper and lower eyelids; Vaccinations have flared up all her medical conditions; swelling of the left side of her face; Abdominal pain; rash on upper cheek bone is coming back; Bilateral Red Rash on Cheek area; Woke up with a rash on lower right jaw bone, Rash Grew to the entire Face; Burning Nerve Pain on the Face, Ear Canal, and Skull; Red Eyes; Very Dry Eyes; Swollen Face; Hot Face; eye problems; Fever; Nausea; Muscle Pain; Joint Pain; Swollen Lymph Nodes under Jaw; This spontaneous case was reported by an other health care professional (subsequently medically confirmed) and describes the occurrence of VOMITING (Vomiting), RASH (Woke up with a rash on lower right jaw bone, Rash Grew to the entire Face) and NEURALGIA (Burning Nerve Pain on the Face, Ear Canal, and Skull) in a 39-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 023M20A and 028L20A) for COVID-19 immunisation. The occurrence of additional non-serious events is detailed below.     Concurrent medical conditions included Ehlers-Danlos syndrome, Mast cell activation syndrome, Postural orthostatic tachycardia syndrome, Erythromelalgia, Cystitis interstitial, Delayed gastric emptying, Acid reflux (esophageal), Osteopenia, Occipital neuralgia (Occipital Myalgia) and Allergy. Concomitant products included PENTOSAN POLYSULFATE SODIUM (ELMIRON), PROPRANOLOL, DEXLANSOPRAZOLE (DEXILANT), FAMOTIDINE, ETHINYLESTRADIOL, LEVONORGESTREL (CAMRESE) and DIPHENHYDRAMINE HYDROCHLORIDE (BENADRYL [DIPHENHYDRAMINE HYDROCHLORIDE]) for an unknown indication, ALPRAZOLAM (XANAX).   On 21-Jan-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 18-Feb-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. On 18-Feb-2021, the patient experienced VOMITING (Vomiting) (seriousness criterion hospitalization), LYMPHADENOPATHY (Swollen Lymph Nodes under Jaw), PYREXIA (Fever), NAUSEA (Nausea), MYALGIA (Muscle Pain) and ARTHRALGIA (Joint Pain). On 23-Feb-2021, the patient experienced RASH (Woke up with a rash on lower right jaw bone, Rash Grew to the entire Face) (seriousness criterion hospitalization), NEURALGIA (Burning Nerve Pain on the Face, Ear Canal, and Skull) (seriousness criterion hospitalization), OCULAR HYPERAEMIA (Red Eyes), DRY EYE (Very Dry Eyes), SWELLING FACE (Swollen Face), FEELING HOT (Hot Face) and EYE DISORDER (eye problems). On 25-Feb-2021, the patient experienced RASH ERYTHEMATOUS (Bilateral Red Rash on Cheek area). On 05-Mar-2021, the patient experienced RASH (rash on upper cheek bone is coming back). On 08-Mar-2021, the patient experienced ABDOMINAL PAIN (Abdominal pain) and SWELLING FACE (swelling of the left side of her face). On 09-Mar-2021, the patient experienced EYELID CYST REMOVAL (Had a procedure performed by a HCP to pop five styes on her upper and lower eyelids) and CONDITION AGGRAVATED (Vaccinations have flared up all her medical conditions). On 22-Feb-2021, VOMITING (Vomiting), PYREXIA (Fever), NAUSEA (Nausea), MYALGIA (Muscle Pain) and ARTHRALGIA (Joint Pain) had resolved. On 25-Feb-2021, RASH (Woke up with a rash on lower right jaw bone, Rash Grew to the entire Face), NEURALGIA (Burning Nerve Pain on the Face, Ear Canal, and Skull), OCULAR HYPERAEMIA (Red Eyes), DRY EYE (Very Dry Eyes), SWELLING FACE (Swollen Face), FEELING HOT (Hot Face) and RASH ERYTHEMATOUS (Bilateral Red Rash on Cheek area) had resolved. At the time of the report, LYMPHADENOPATHY (Swollen Lymph Nodes under Jaw), EYE DISORDER (eye problems) and RASH (rash on upper cheek bone is coming back) had not resolved and EYELID CYST REMOVAL (Had a procedure performed by a HCP to pop five styes on her upper and lower eyelids), ABDOMINAL PAIN (Abdominal pain), CONDITION AGGRAVATED (Vaccinations have flared up all her medical conditions) and SWELLING FACE (swelling of the left side of her face) outcome was unknown.        For mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular), the reporter did not provide any causality assessments.   Treatment medications included: Cromolyn Sodium 100mg/5ml orally daily, and applying to face topically, Naltrexone 4.5mg, Zirbel , Myrbetriq 60mg daily, Ondansetron 8mg prn nausea, Hydroxyzine 25mg, Hemax , Hyoscyamine 0.1 Oral PRN, Benadryl for bilateral rash on cheek area, Aleve, Advil and Tylenol. She ended up in the ER a couple of times and visited Immunologist and other specialists. She stated she has been out of work since 21Jan2021. She stated that she takes Zyrtec (as needed) and received a Benadryl intramuscular shot on 08Mar2021.   This case was linked to MOD-2021-068238 (Patient Link).   Most recent FOLLOW-UP information incorporated above includes: On 10-Mar-2021: Updated patient medical history, added new events, and treatment medications.; Reporter's Comments: one more drug the patient was consuming was Hizentai 8 gms per week.; Sender's Comments: Based on the current available information and temporal association between the use of the product and the start date of the events, a causal relationship cannot be excluded