idiopathic anaphylaxis; itchy hands and feet; facial swelling; tongue swelling; airway swelling; abdominal pain; hives; diarrhea; Upset stomach; This is a spontaneous report from a contactable nurse (patient). This 35-year-old female patient received bnt162b2 (PFIZER-BIONTECH COVID-19 VACCINE, lot number: EL1253) via an unspecified route of administration in the right deltoid on 21Jan2021 at age of 35 years old as single dose for COVID-19 immunization. Medical history and concomitant medications were none. The patient previously received the 1st dose of bnt162b2 (PFIZER-BIONTECH COVID-19 VACCINE, lot number: EL0140) via an unspecified route of administration in the right deltoid on 31Dec2021 at age of 35 years old for COVID-19 immunization, experiencing diarrhea, upset stomach, itchy hands and feet. The patient received the Pfizer Covid Vaccine in Jan2021, since then she had been suffering with idiopathic anaphylaxis specifically since the second vaccine. She went into anaphylaxis for no reason or rhyme. She had went to an allergist immunologist, and they can find no reason aside from vaccine itself. It happened 2 days after the second dose, she woke up in middle of the night with itchy hands and feet as well as facial swelling and tongue swelling in Jan2021. She had to call 911. She added that she also had airway swelling in Jan2021. There was also abdominal pain, diarrhea, and hives in Jan2021. The reporter clarified that it was actually her son that called to call 911 and he was only 6 years old. The reporter stated that she had already reported this on VAERS. She wanted to let Pfizer know what was happening. This had changed her life, she was now financially struggling and emotionally struggling. She was also a Registered Nurse and did this with good intent, but she was now brutally suffering for it. The first anaphylaxis reaction happened 2 days after, on 23Jan2021, this was the same night 911 was called, she went to the ER, she was in a smaller community, and when she went to the ER the hospital was full, and so they treated her outside till she got to baseline and the swelling went down with steroids, Epi pen, and Benadryl. The patient clarified that after the first dose on 31Dec2020, 2 days after she experienced itchy hands and feet and upset stomach, but when she got the second dose that's when it really hit her. She initially went to Nurse Practitioner but this NP had now gone to practicing in urgent care. There was an allergist immunologist clinic that she went to and at that facility she saw the allergist immunologist Dr, and saw another physician at that office Dr. who was also an allergist immunologist. Anaphylaxis Outcome: It randomly happened every few months or multiple times in a month, there was no pattern. She initially thought it was improving but then in Jun2021 she had an episode that needed Epinephrine 3 times before she got relief. Itching happened during each reaction and varies with each episode, initially it was like a clue that the reaction was coming, so then she would dose with Benadryl, get the Epipen ready, and get close to an ER facility. Seriousness Criteria: Her entire body system was going into that. The patient selected hospitalization but then clarified that it didn't get to the point of being admitted into the hospital. The patient saw an allergist immunologist they did testing for food (allergy test), environmental, PEG polyethylene Glycol testing, they event tested for autoimmune disorders but everything was normal. The patient had just the excessive labs and abdominal scans which were all normal. Only tests she had are from the allergist and ER. She had no allergies. She had used 20 or more EpiPens, she can't give all the Lots. She only had EpiPen's that were unused, they were not used at all. All previous EpiPen's that were used have been discarded and she had no Lot. Steroid name she thought was Prednisone, she was not sure, or the generic for it. They give it to her with each episode. Benadryl was used during an episode. Outcome of the events was not recovered.; Sender's Comments: As there is limited information in the case provided, the causal association between the event Anaphylactic reaction and the suspect drug BNT162B2 cannot be excluded. The case will be reassessed once new information is available.