fatigued; headache; This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP) from medical information team. The reporter is the patient.  A 71 year-old female patient received bnt162b2 (COMIRNATY) (Lot number: EN5318, Expiration Date: May2021) as dose 1, single for covid-19 immunisation. Relevant medical history included: "Traumatic brain injury", start date: Feb2019 (unspecified if ongoing), notes: In Feb2019 she was in a car accident and had a traumatic brain injury/concussion.; "Car accident", start date: Feb2019 (unspecified if ongoing), notes: In Feb2019 she was in a car accident and had a traumatic brain injury/concussion.; "TDI", start date: Feb2019 (unspecified if ongoing); "head concussion", start date: Feb2019 (unspecified if ongoing). The patient's concomitant medications were not reported. The following information was reported: FATIGUE (non-serious), outcome "recovered" (2021), described as "fatigued"; HEADACHE (non-serious), outcome "recovered" (2021), described as "headache".  Additional information: After her first vaccine she just experienced a headache and was fatigued for a few days (couple days). Caller received second dose of the Pfizer BioNTech Covid 19 vaccine on 26Feb2021. After her second dose, she had headaches and a sore arm, her lymph nodes in her arms swelled up, had a fever for a couple of days (for two days) and could not really concentrate. In Feb2019 she was in a car accident and had a traumatic brain injury/concussion. The synapses around her brain were injured causing numbness. After getting the second vaccine, she said it felt like her car accident all over again with the numbness. This side effect lasted about a month. Five to six weeks after the second dose, she got bloodwork done for the cardiologist and he called her and asked what she had been doing, that all of her enzymes were all elevated, liver, pancreas, everything. She hadn't done anything differently in that time other than get the vaccine. Her husband had all three shots and had virtually no side effects other than fatigue. She was calling to see if those side effects were caused by the vaccine. What was the probability that a rise in enzymes would happen again? Asked whether she should get the third dose of the vaccine. Can getting the vaccine cause a false positive? She was planning a trip to (Withheld) in November. Is the third dose the same as the second dose? She thought it was a quarter of the second dose but then read it was the same dose. Are the side effects from the third dose worse than from the second dose? She did have a mitral valve prolapse but has not had any heart inflammation from the vaccines. Investigation Assessment: Yes (but result not provided). After the first test she had sore arm another test, shot sore arm and had a headache. After the second shot, she had the sore arm, the headache. She had a headache and in February of 2019, I meet with a car accident and had a Traumatic Brain Injury, TDI and head concussion, after she had the second shot her head were where she had head like concussion where like the synapses around the brain has been injured. She thought she had her car accident all again (Further not clarified). She was numb, had the headache. Had to wait to the couple weeks before the numbness went away and had difficulty concentrating and thinking and then its sixth week after the second shot she coincidentally went for my blood work up (Further not clarified) for my cardiologist for the check up and the doctor called me right away and said what had you been doing and she said nothing the only thing was different she had the COVID shot. We would all of my enzymes and all of my organs were up two or three times what the normal level should have been and that then include my liver, my pancreas, they sent her for the test for my gall bladder because she had some pain and they did my gall bladder out but then eventually in the next couple month the enzymes all went down again and her doctor took her on Lipitor (Treatment) and anyway the only enzymes that never went down for the whole time that was not the problematic all the Liver enzymes. So, she was just curious at had been any report saying that the liver enzymes were affected by the COVID Vaccination because she was supposed to get her third shot on Monday. She just (incomplete sentence). Her doctor told her to test what her liver enzymes were now and because she was not on Lipitor (Further not clarified) or anything right now and she was just trying to whether its safe for her to get that shot. It would be the third shot which she understood was the same thing as the second dose, but she was getting on Monday but on the liver enzymes that might be side effect that not going away. That was her question. Should she get the shot with the enzymes going up? Product details (NDC, UPC number and treatment) and Pharmacy details could not be probed as consumer was unwilling to share further information. Hence further probing could not be done. Limited information available over the call.  No follow-up attempts are possible. No further information is expected.