blood pressure drops when he stands, and it returns to normal when he lays down; Blood pressure as high as 135/84 (usually 105/75); Blood pressure as low as 56/85; Dizziness; Calcium build up in his coronary arteries; Pressure in his back; Pressure in his rib cage; Shortness of breath; This spontaneous case was reported by a consumer and describes the occurrence of DYSPNOEA (Shortness of breath) and ORTHOSTATIC HYPOTENSION (blood pressure drops when he stands, and it returns to normal when he lays down) in a 66-year-old male patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 042220A OR 042620A and 003A21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     No Medical History information was reported.   On 29-Jan-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 05-Mar-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 31-Jul-2021, the patient experienced DYSPNOEA (Shortness of breath) (seriousness criterion medically significant). On an unknown date, the patient experienced ORTHOSTATIC HYPOTENSION (blood pressure drops when he stands, and it returns to normal when he lays down) (seriousness criterion medically significant), HYPERTENSION (Blood pressure as high as 135/84 (usually 105/75)), HYPOTENSION (Blood pressure as low as 56/85), DIZZINESS (Dizziness), ARTERIOSCLEROSIS CORONARY ARTERY (Calcium build up in his coronary arteries), MUSCULOSKELETAL DISCOMFORT (Pressure in his back) and MUSCULOSKELETAL CHEST PAIN (Pressure in his rib cage). At the time of the report, DYSPNOEA (Shortness of breath), ORTHOSTATIC HYPOTENSION (blood pressure drops when he stands, and it returns to normal when he lays down), HYPERTENSION (Blood pressure as high as 135/84 (usually 105/75)), HYPOTENSION (Blood pressure as low as 56/85), DIZZINESS (Dizziness), ARTERIOSCLEROSIS CORONARY ARTERY (Calcium build up in his coronary arteries), MUSCULOSKELETAL DISCOMFORT (Pressure in his back) and MUSCULOSKELETAL CHEST PAIN (Pressure in his rib cage) outcome was unknown.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On an unknown date, Cardiac stress test: abnormal (abnormal) calcium build up in his coronary arteries. On an unknown date, Oxygen saturation: 98 (normal) 98 and 80 (Low) 80.         No Treatment informations were reported.  The patient reported that he undergone various tests and visited hospital for the same. They conducted the tests in the hospital in 3 days period.On unknown date patient undergone pulmonary embolism test, no results were reported.After all the tests, there was still no answer to what was causing his shortness of breath. From the tests that were done, his heart function is normal, the stress test indicated calcium build up in his coronary arteries but it not of concerns to his doctor, it's so minor they can't go in to put in a stent. The patient did not experience symptoms like this before. The patient was still experiencing symptoms (not specified) at the time of this report.  Company Comment: This case concerns a 66-year-old male patient with no reported medical history who experienced unexpected events of dyspnea and orthostatic hypotension. The event occurred 3 months 26 days after the second dose of mRNA-1273 (Moderna COVID-19 Vaccine) administration. The re-challenge was not applicable as event occurred after the second dose administered. Causality for the reported events were not provided by the reporter. The benefit-risk relationship of mRNA-1273 (Moderna COVID-19 Vaccine) is not affected by this report. Event is assessed as serious per Regulatory Authority reporting. As event required hospitalization.; Sender's Comments: This case concerns a 66-year-old male patient with no reported medical history who experienced unexpected events of dyspnea and orthostatic hypotension. The event occurred 3 months 26 days after the second dose of mRNA-1273 (Moderna COVID-19 Vaccine) administration. The re-challenge was not applicable as event occurred after the second dose administered. Causality for the reported events were not provided by the reporter. The benefit-risk relationship of mRNA-1273 (Moderna COVID-19 Vaccine) is not affected by this report. Event is assessed as serious per Regulatory Authority reporting. As event required hospitalization.