hives; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP) from medical information team. The reporter is the patient.  An 81-year-old female patient received BNT162b2 (BNT162B2), on 04Oct2021 at 14:50 as dose 3 (booster), single (Lot number: FF8811) at the age of 81 years for covid-19 immunisation. The patient's relevant medical history included: "Scoliosis" (ongoing), notes: scoliosis was diagnosed at least 10 years or 7-8 years ago.; "Osteoporosis" (ongoing); "Arthritis" (ongoing); "spinal stenosis" (ongoing); "Polio" (unspecified if ongoing), notes: she had polio as a child; "two little fractures in her lower bones in her back" (unspecified if ongoing), notes: two little fractures in her lower bones in her back; "she also has a walker she uses" (unspecified if ongoing), notes: she also has a walker she uses. There were no concomitant medications. Vaccination history included: BNT162b2 (DOSE 1, SINGLE, Lot No: EN6208), administration date: 10Mar2021, when the patient was 81-year-old, for Covid-19 immunization, reaction(s): "Hives"; BNT162b2 (DOSE 2, SINGLE, Lot No: ER8737), administration date: 31Mar2021, when the patient was 81-year-old, for Covid-19 immunization, reaction(s): "Hives". No Prior Vaccinations (within 4 weeks). No illness at the time of her vaccination. No Family Medical History Relevant to Adverse Events (AEs).   The following information was reported: URTICARIA (medically significant) with onset 2021, outcome "not recovered", described as "hives". The event "hives" required physician office visit and emergency room visit. The patient underwent the following laboratory tests and procedures: Blood test: Unknown results, notes: Had a lot of blood tests and they were trying to figure out why the hives and apparently the doctor figured it was the Pfizer vaccine; Body height: 5 feet 5 inches. Therapeutic measures were taken as a result of urticaria, pruritus, arthropod sting.  Patient reported that she received Pfizer covid-19 vaccine booster shot and experienced hives after. Asked for recommendations or anything she can do to treat her hives. She had been received hive short time after the booster, continued going to her primary and dermatologist but after weeks and months they just gave her Prednisone, anything you could think of but nothing works. Allergist gave her a once a month injection "Explar" (sounds like but not verified, she may be pertaining to XOLAIR), However, she had her last injection on Friday at 2PM, but this weekend was a unbelievable breakout of hives, on just the right side, broke out and itchy, she used lotions and took showers and lotions to stop the itching. They also felt like a bee stings, felt like she was being stung by thousand of bees that would come and go, so it was a very uncomfortable weekend. This morning on top of her right hand and knuckles, that's new. She said that she started Explar (the injection, might be referring to XOLAIR) in December, she have a packet prednisone that she could not take. She also mentioned that she heard a lot of people have gotten hives after getting the Pfizer covid-19 shot. She verified that she received Pfizer covid-19 shots and the booster shot (unsure if it is a bivalent). She added that "people who have gotten hives, one side of body which is a mystery, thankfully it is not all over just on the right side shoulder down to her hips it is very very torture, itch like a crazy you just wanna dig in but you don't dare cause you don't wanna open up any sores". Since she had the injections she has been dealing with severe outbreak of hives just on the right side and so she has gone to her primary care physician and dermatologist over and over these three years and they do not know what to do. She was sent to an allergist and they did an extreme amount of blood tests and checked her and the hives and came to the conclusion that the hives were caused by the Pfizer Injection. As of Dec2022 she was started on injections in each arm called Xlara and carries an epi-pen with it and her last injection of Xlara was Friday and her hives are unbelievable now and she can't believe nothing is working and she is also on Allegra which has side effects. Wants to know what can she do to get rid of the hives, and her allergist is trying but is stumped. This has ruined her life. Reporter details: States her hives are going crazy; hives began in 2021 and she is age 83 now so was age 79 or 80 and thinks she was age 80 when the hives began as it was Mar2021 and after two vaccines and then the booster. Patient details: She used to be 5 feet 5 inches but due to scoliosis she is shrinking; they diagnosed her whole back and she had polio as a child and the scoliosis was diagnosed at least 10 years or 7-8 years ago and she also has osteoporosis, arthritis and spinal stenosis and two little fractures in her lower bones in her back and all of these diagnoses were prior to the Pfizer covid vaccines; she also has a walker she uses. After her shots, she broke out in the hives and the primay care doctor and dermatologist finally gave up and she will see an allergist; has her medication list with her. Hives began in 2021 and she would say late 2021 and the hives are worsening now.  (Withheld) is where she gets the injections in her arms and clarified the spelling is Xlair injection; spelling captured as provided by the caller and she gets one of those in each arm each month. She had the booster dose that Monday at 2:50pm and it was at the (Withheld) with phone (Withheld) and the pharmacy stamped the address so has to get a magnifying glass as it is so tiny and she can't see it but the stamp is so small in and can't read the pharmacy information. The hives did not result in a hospitalization but did result in a visit to the emergency room and they gave her a shot of Benadryl drip and of course then she could not drive. Other medical conditions: Her back is a mess other than that she is very healthy. States her heart, blood pressure and you name it whatever it is called and then caller pauses and states she is really loopy now and is on Allegra but is really healthy except for her back. Caller was asked for the dose and manufacturer of the Allegra but only provided she takes the Allegra one a day and just started it today for the first time. The weekend as a total nightmare and she had the Xlair injection on Friday at 2pm and had a mammoth breakout of hives on the right side and the hives are in a line so they gave her Allegra samples and she did not take them with her Alprazolam or orange juice as they said not to do that so she did not take the Allegra until today but is kind of loopy. Investigations: Had a lot of blood tests and they were trying to figure out why the hives and apparently the doctor figured it was the Pfizer vaccine. When she first started going to the provider, she thinks back in October or November of last year, she had the Xlair injections and had two of them one in each arm and the first three times she did that she would sit in the waiting room for 2 hours and was then ready to go and had to be alert in case she went into whatever and has not had to use her epi-pen; the Xlair injections began Dec2022 or so about in October or Nov2022 was when she started seeing him because her primary care and dermatologist gave up; they were putting her on prednisone all the time and that's not safe.; Sender's Comments: Linked Report(s) : US-PFIZER INC-202300233528 same patient, different dose;US-PFIZER INC-202300233529 same patient, different dose;