Fatigue; This spontaneous case was reported by a consumer and describes the occurrence of FATIGUE (Fatigue) in a 65-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch no. 015M70A) for COVID-19 vaccination.     The patient's past medical history included De Quervain's tenosynovitis (De Quervain's tenosynovitis), Cervical radicular pain (Cervical radicular pain), Sclerosis multiple (Nuclear sclerosis, right), Dysphagia (Dysphagia), Epigastric pain (Epigastric pain), Gastric ulcer (Gastric ulcer) since an unknown date, DVT (History of DVT in adulthood) since an unknown date, Dyslipidemia (Dyslipidemia) since an unknown date, Seizures (Seizures last episode over ten years ago) since an unknown date, Gastroesophageal reflux disease (Gastroesophagal reflux disease without esophagitis), Clostridium difficile infection (Occurred twice, secondary to antibiotic), Limb immobilization (Limb immobilization) on 28-Feb-2021, Ultrasonography (Ultra sonography of right Jugular veins, guidance) on 01-Mar-2021, Central venous catheterization (Central venous catheterization) on 01-Mar-2021, Ventilation difficult (Ventilation difficult) on 01-Mar-2021, Central venous catheter removal (Central venous catheter removal) on 01-Mar-2021, Endotracheal intubation (Endotracheal intubation) on 01-Mar-2021, External fixation of fracture (External fixation of fracture) on 02-Mar-2021, Removal of external fixation (Removal of external fixation) on 07-Mar-2021, External fixation of fracture (External fixation of fracture) on 07-Mar-2021, Assisted ventilation (Assisted ventilation) on 10-Mar-2021, Transfusion (Transfusion) on 10-Mar-2021, Pleural cavity drainage (Pleural cavity drainage) on 11-Mar-2021 and Rehabilitation therapy (Rehabilitation therapy) on 12-Mar-2021. Family history included Colon cancer (Family history of colon cancer) since an unknown date. Concurrent medical conditions included Drug allergy (Allergy to Prochlorperazine), Drug allergy (Allergy to Anakinra), Drug allergy (Allergy to Brimonidine), Drug allergy (Allergy to Quinolones), Drug allergy (Allergy to Flecainide), Drug allergy (Allergy to Acebutolol), Drug allergy (Allergy to Atenolol), Drug allergy (Allergy to menthol contain prod), Drug allergy (Allergy to Prochlorperazine Edisylate), Intrinsic asthma (Intrinsic asthma without status asthamaticus without complication), Hyperlipidemia (Hyperlipidemia), Obstructive sleep apnea syndrome (Obstructive sleep apnea syndrome), Pulmonary hypertension (Pulmonary hypertension), Idiopathic progressive polyneuropathy (Idiopathic progressive polyneuropathy), Multiple sclerosis (Multiple sclerosis), Psoriatic arthritis (Psoriatic arthritis), Type 2 diabetes mellitus (Type 2 Diabetes without complication), Trigeminal neuralgia (Trigeminal neuralgia), Eczema (Intrinsic Eczema), Facet joint arthropathy (Facet arthropathy, lumbar), Degeneration of lumbar or lumbosacral intervertebral disc (Degeneration of lumbar/ lumbosacral disc without myelopathy), Lumbosacral sprain (Chronic lumbosacral pain), Spondylosis (Spondylosis of cervical region without myelopathy or radiculopathy), Facet joint arthropathy (Facet arthropathy, cervical), Premature ventricular contractions (Premature ventricular contractions), Glaucoma (Open angle glaucoma of right eye, mild stage), Weight abnormal (Over weight), Spinal stenosis of lumbar region (Spinal stenosis lumbar region with neurogenic claudication), Acute on chronic respiratory failure (Acute on chronic respiratory failure with hypoxia), Osteoporosis, Atrial fibrillation (Atrial fibrillation), Type 2 diabetes mellitus (Uncontrolled type 2 diabetes with hyperglycemia), Essential hypertension (Essential hypertension), Obesity (Obesity BMI is 30-39.9), Psoriasis (Psoriasis), Degenerative disc disease (DDD (Degenerative disc disease) lumbar), Degenerative disc disease (DDD (Degenerative disc disease), Cervical) and Atrial fibrillation (Atrial fibrillation). Concomitant products included ALENDRONATE SODIUM (ALENDRONATE), ATORVASTATIN, CARVEDILOL, CLOBETASOL, CLOPIDOGREL BISULFATE (CLOPIDROGEL SANDOZ), CYCLOBENZAPRINE, FAMOTIDINE, FUROSEMIDE, GABAPENTIN, GLIPIZIDE, HYDROCORTISONE, LATANOPROST, LEFLUNOMIDE, LEVETIRACETAM, METFORMIN, MORPHINE SULFATE, MUPIROCIN, NYSTATIN (NYSTOP), ONDANSETRON, OXAZEPAM, PANTOPRAZOLE, PREGABALIN, PREGABALIN, CICLOSPORIN (RESTASIS), SUMATRIPTAN, BUDESONIDE, FORMOTEROL FUMARATE (SYMBICORT), TIMOLOL and SALBUTAMOL (VENTOLIN [SALBUTAMOL]) for an unknown indication.   On 26-Feb-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On an unknown date, the patient received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 2 dosage form. On an unknown date, the patient experienced FATIGUE (Fatigue). At the time of the report, FATIGUE (Fatigue) outcome was unknown. Not Provided          The treatment history was not provided. The patient was on Long term use of Blood Thinners and had Family history Colon Cancer. Also the patient had Renal Failure which required Dialysis (chronic phlebotomy to check renal labs).The patient was admitted to Rehabilitation Centre for 10 Days.  Other procedures done on the patient were performance of Urinary Filtration, intermittent, less than 6 hours per day on 01 MAR-2021, on 28-FEB-2021 Respiratory arrest in emergency department and 29-FEB-2021 Multiple episodes of rapid Atrial Fibrillation with swat response. Episode up to 200 requiring doses of intravenous Cardizem(three episodes) and sublingual nitroglycerine.   This case was linked to MOD-2021-300410 (Patient Link).