Major case of shingles; This is a spontaneous report from a contactable consumer (patient herself). A 60-year-old non-pregnant female patient received bnt162b2 (BNT162B2, Formulation: Solution for injection, Lot number: EP6955, NDC number: Unknown, Expiration date: Unknown), via an unspecified route of administration, administered in Left arm on 25Mar2021 at 07:30 (at the age of 60-years-old) as 1ST DOSE, SINGLE for covid-19 immunisation. Medical history included covid-19, a year ago in March. The patient had no allergies to medications, food, or other products. Other conditions and Investigations were not provided. Concomitant medications included losartan (LOSARTAN) taken for an unspecified indication, levothyroxine sodium (SYNTHROID) taken for an unspecified indication on an unspecified date received within 2 weeks of vaccination. The patient did not receive any other vaccines within 4 weeks prior to the COVID vaccine. The patient was diagnosed with COVID-19 prior to vaccination in march a year ago. The patient has not been tested for COVID-19 since the vaccination. It was reported other vaccine same date details: 25Mar2021. It was reported that, the patient received second dose of bnt162b2 (BNT162B2, Formulation: Solution for injection, Lot number: EW0167), via an unspecified route of administration, administered in Left arm on 13May2021 at 11:00 for covid-19 immunisation. On 10Apr2021 at 13:00, the patient had Major case of shingles/shingles two weeks after her first dose of the shot, which she reported to Pfizer already. Adverse event resulted in Emergency room/department or urgent care. Treatment for adverse event included Valtrex. The patient received 14 days of antiviral therapy after the first dose for shingles. She wanted to know if she can take the antiviral again prophylactically, so she does not have shingles again after her second dose yesterday (received after 50 days from the first dose). Caller stated that others have developed shingles after the vaccine so it would be a side effect. She said she has two doctors that said for her to wait to have her second shot, until her shingles symptoms cleared up, so she had her second shot yesterday. She said she had her second COVID shot at about 50 days out from her first dose. She said her question was that she was wondering because she was not sure if she might get another case of shingles from the second shot, if she should start an antiviral medication to prevent that, but she doesn't want to jeopardize the Pfizer COVID-19 vaccine. She says she has seen where a lot of different people, including four of her neighbors, got shingles after getting the Moderna or Pfizer COVID-19 shot. The reporter wanted to know if she can start an antiviral medication to prevent getting shingles again from the Pfizer COVID-19 vaccine and if antiviral would affect the efficacy of the Pfizer covid vaccine and interfere with the vaccine? She said her first dose LOT: EP6955. She said this dose was injected in her left arm. The reporter declines to complete reports on her neighbours who had shingles after their first doses and said she doesn't have their information to provide. She said she told them they should report it, she said she doesn't know their information, but her colleague also has two friends that got shingles as well. No further details reported, captured, or documented about her neighbors or her colleague's friends. Caller said that she has no new things to add to her previous report. The reporter assessed event as non-serious with no seriousness criteria of resulting in death, Life threatening, Caused or prolonged hospitalization, Disabling or Incapacitating, Congenital anomaly or birth defect. The outcome of the event was not recovered.  No follow-up attempts are needed. No further information is expected.; Sender's Comments: Linked Report(s) : US-PFIZER INC-2021551647 same reporter/drug/event, different patient