his legs gave way; legs gave way and he fell; no energy to move; feeling fever/fever reached 103 degrees; muscle aches; joint pain; he cannot go for walks; has hard time putting his shoes or under ware on.; This case was reported by a consumer via call center representative and described the occurrence of fever in a 54-year-old male patient who received Herpes zoster (Shingrix) for prophylaxis.   On 1st February 2021, the patient received the 2nd dose of Shingrix (intramuscular). On 1st February 2021, 4 hrs after receiving Shingrix, the patient experienced fever (serious criteria hospitalization), muscle pain (serious criteria hospitalization), joint pain (serious criteria hospitalization), unable to walk and activities of daily living impaired. On 2nd February 2021, the patient experienced lower extremities weakness of (serious criteria hospitalization), fall (serious criteria hospitalization) and loss of energy (serious criteria hospitalization). The patient was treated with soma (nos) (Soma). On 2nd February 2021, the outcome of the fever was recovered/resolved. On an unknown date, the outcome of the muscle pain, joint pain and loss of energy were not recovered/not resolved and the outcome of the lower extremities weakness of, unable to walk and activities of daily living impaired were unknown and the outcome of the fall was recovered/resolved.   The reporter considered the fever, muscle pain, joint pain, lower extremities weakness of, fall, loss of energy, unable to walk and activities of daily living impaired to be related to Shingrix.  Additional details were provided as follows: On 1st February 2021, the patient received 2nd dose of Shingrix on an unknown arm (not entirely sure of the date, might have been 2nd February 2021) and started feeling fever, muscle aches and joint pain. The muscles ached so much the night of the Shingrix vaccine, the patient was afraid to move and his fever reached 103 degrees F. The patient stated that, the next day the fever resolved, but the muscles and joints where still sore. The same night, he went in the bathroom and his legs gave way and he fell on the bathroom floor.  The patient's wife assisted the patient back on his feet and about 2 to 3 minutes later he fell again due to his legs giving out. The patient reported that, he had no energy to move, so his wife called the Emergency medical services and he was transported to the hospital. The patient stayed in the hospital for 2 or 3 days. The hospital informed the patient that, he had a reaction to the Shingrix vaccine.  The patient also stated that, ever since being released from the hospital, he still had muscle and joint pain everywhere (every joint). Due to the muscle aches and joint pain he could not go for walks and had a hard time putting his shoes or under wear on. The patient also stated that his Healthcare professional had put him on Soma, but that had done nothing to help his symptoms, so he had a call into his Healthcare professional on trying something else (caller did not share strength/dosing of Soma). Emergency visit was required for the patient. The reporter did not consent to follow up. The reporter does not give permission to contact Healthcare professional.