involving the high fever occurring within 10 hours of the vaccine was the same experience with the last 2 booster shots.; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP).  A 58-year-old female patient received BNT162b2 (BNT162B2), on 21Aug2021 as dose 3 (booster), 0.3 ml single (Lot number: FC3181, Expiration Date: 31Oct2021) at the age of 58 years for covid-19 immunisation. The patient's relevant medical history included: "heart transplant recipient", start date: 09Apr2020 (unspecified if ongoing), notes: Comments: heart transplant recipient; "Metastatic breast cancer", start date: 2007 (unspecified if ongoing), notes: Patient did not have chemo or radiation.; "to prevent organ rejection" (unspecified if ongoing); "Headache" (unspecified if ongoing); "blood clot" (unspecified if ongoing); "water retension" (unspecified if ongoing); "hear it is for blood pressure" (unspecified if ongoing); "something about cholesterol or whatever" (unspecified if ongoing); "something for stomach" (unspecified if ongoing). Concomitant medication(s) included: PREDNISONE taken for organ transplant, start date: 09Apr2020 (ongoing); TACROLIMUS taken for organ transplant (ongoing); TYLENOL taken for headache (ongoing); ELIQUIS taken for thrombosis (ongoing); FUROSEMIDE taken for fluid retention (ongoing); LOSARTAN taken for blood pressure abnormal, blood cholesterol abnormal (ongoing); PANTOPRAZOLE taken for abdominal discomfort (ongoing); ROSUVASTATIN taken for diabetes mellitus (ongoing); CARVEDILOL taken for blood pressure abnormal (ongoing); ALBUTEROL [SALBUTAMOL SULFATE] (ongoing); MIRALAX (ongoing); CALCIUM CITRATE + D. Past drug history included: Sirolimus, notes: stopped this medication prior to this all occurring with the Covid vaccines, probably in the last 2 years. Vaccination history included: BNT162b2 (Dose: 1, LOT: looks like EN6200, NDC, EXP: Unknown), administration date: 22Feb2021, when the patient was 58-year-old, for COVID-19 Immunization, reaction(s): "COVID-19"; BNT162b2 (Dose: 2, LOT: EN6208, NDC, EXP: Unknown), administration date: 15Mar2021, when the patient was 58-year-old, for COVID-19 Immunization, reaction(s): "COVID-19". The following information was reported: PYREXIA (hospitalization) with onset Aug2021, outcome "unknown", described as "involving the high fever occurring within 10 hours of the vaccine was the same experience with the last 2 booster shots.". The patient was hospitalized for pyrexia (start date: 22Aug2021, discharge date: 28Aug2021, hospitalization duration: 6 day(s)). The event "involving the high fever occurring within 10 hours of the vaccine was the same experience with the last 2 booster shots." required physician office visit. The patient underwent the following laboratory tests and procedures: Pyrexia: High. Clinical course: Reporter clarified that it was after this First booster shot that the patient went to the hospital. She had gotten the shot, in the morning on 21Aug2021 and the next day, 22Aug2021, went to the hospital. Was admitted to the hospital for 6 days, starting on 22Aug2021. Further clarified that this experience, involving the high fever occurring within 10 hours of the vaccine was the same experience with the last 2 booster shots. Patient tried eating and caller would have to force her to eat. All these experiences were pretty much identical. After the first episode, she saw the cardiologist and even saw her primary doctor.; Sender's Comments: Linked Report(s) : US-PFIZER INC-202201256326 Same patient/drug, different dose;US-PFIZER INC-202201256280 Same patient/drug, different dose;