Hives after booster; She also has some chest tightening; She is also tired and drowsy; She is also tired and drowsy; she feels a discomfort in the throat,as if she can't swallow; It also feels like throat tightening; Redness all over the body/it moved around to the back of her ears, scalp, legs, torso, hands, and arms; Scratchy all over the body/it moved around to the back of her ears, scalp, legs, torso, hands, and arms; Rash all over the body; This spontaneous case was reported by a consumer and describes the occurrence of ERYTHEMA (Redness all over the body/it moved around to the back of her ears, scalp, legs, torso, hands, and arms), SCRATCH (Scratchy all over the body/it moved around to the back of her ears, scalp, legs, torso, hands, and arms), URTICARIA (Hives after booster), OROPHARYNGEAL DISCOMFORT (she feels a discomfort in the throat,as if she can't swallow) and THROAT TIGHTNESS (It also feels like throat tightening) in a 49-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 034F21A, 007C21A and 036A21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     No Medical History information was reported.   On 01-Apr-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 29-Apr-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 18-Nov-2021, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 29-Nov-2021, the patient experienced ERYTHEMA (Redness all over the body/it moved around to the back of her ears, scalp, legs, torso, hands, and arms), SCRATCH (Scratchy all over the body/it moved around to the back of her ears, scalp, legs, torso, hands, and arms) and RASH (Rash all over the body). On 07-Jan-2022, the patient experienced OROPHARYNGEAL DISCOMFORT (she feels a discomfort in the throat,as if she can't swallow) and THROAT TIGHTNESS (It also feels like throat tightening). On an unknown date, the patient experienced URTICARIA (Hives after booster), CHEST DISCOMFORT (She also has some chest tightening), SOMNOLENCE (She is also tired and drowsy) and FATIGUE (She is also tired and drowsy). The patient was treated with LORATADINE (CLARITIN [LORATADINE]) for Adverse event, at an unspecified dose and frequency; CETIRIZINE HYDROCHLORIDE (ZYRTEC [CETIRIZINE HYDROCHLORIDE]) for Adverse event, at a dose of UNK UNK, qd; CETIRIZINE HYDROCHLORIDE (ZYRTEC [CETIRIZINE HYDROCHLORIDE]) for Adverse event, at a dose of UNK UNK, half and CETIRIZINE HYDROCHLORIDE (ZYRTEC [CETIRIZINE HYDROCHLORIDE]) for Adverse event, at a dose of UNK UNK, bid. At the time of the report, ERYTHEMA (Redness all over the body/it moved around to the back of her ears, scalp, legs, torso, hands, and arms), SCRATCH (Scratchy all over the body/it moved around to the back of her ears, scalp, legs, torso, hands, and arms), CHEST DISCOMFORT (She also has some chest tightening), SOMNOLENCE (She is also tired and drowsy), RASH (Rash all over the body) and FATIGUE (She is also tired and drowsy) outcome was unknown and URTICARIA (Hives after booster), OROPHARYNGEAL DISCOMFORT (she feels a discomfort in the throat,as if she can't swallow) and THROAT TIGHTNESS (It also feels like throat tightening) had not resolved.            No concomitant medications were reported.  The first week patient really felt bad. Some areas of the body was so red and scratchy, and it moved around to the back of her ears, scalp, legs, torso, hands, and arms. Her doctor told her to take Claritin, but it was not doing anything, so she switched to Zyrtec twice daily. After two days of taking Zyrtec, hives were pretty much controlled. Then she moved to one Zyrtec a day and then half a Zyrtec a day. But as soon as the Zyrtec stopped working the hives came back again. She had not administered the Zyrtec on the day of reporting and she felt a discomfort in the throat, as if she cannot swallow. It also felt like tightening. She also had some chest tightening, but not all the time.She was also tired and drowsy.  The doctor initially prescribed a stronger antihistamine called hydroxyzine. But the patient never took it because the Zyrtec was already controlling the hives. She did not felt the need to take anything else.   This case was linked to MOD-2022-445628, MOD-2022-445629.