COVID-19; Lack of drug effect; Rebound Covid after taking paxlovid; This spontaneous case was reported by a consumer and describes the occurrence of COVID-19 (Rebound Covid after taking paxlovid), COVID-19 (COVID-19) and DRUG INEFFECTIVE (Lack of drug effect) in a 50-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination.     Previously administered products included for Product used for unknown indication: Pfizer (Dose 1, anatomical location-Right arm) in March 2021, Pfizer (Dose 2 and anatomical location-Right arm) in April 2021. Past adverse reactions to the above products included No adverse event with Pfizer and Pfizer. Concurrent medical conditions included Allergy (Unknown historical drug). Concomitant products included ACETYLSALICYLIC ACID (ALKA SELTZER [ACETYLSALICYLIC ACID]) from 04-May-2021 to 07-May-2021 and CHLORPHENAMINE MALEATE, PARACETAMOL, PSEUDOEPHEDRINE HYDROCHLORIDE (THERAFLU FLU COLD) from 08-May-2021 to 09-May-2021 for an unknown indication.    In December 2021, the patient received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 14-May-2022, the patient experienced COVID-19 (Rebound Covid after taking paxlovid) and DRUG INEFFECTIVE (Lack of drug effect). On an unknown date, the patient experienced COVID-19 (COVID-19). The patient was treated with NIRMATRELVIR, RITONAVIR (PAXLOVID) from 06-May-2022 to 10-May-2022 for COVID-19 treatment, at an unspecified dose and frequency. At the time of the report, COVID-19 (Rebound Covid after taking paxlovid) had not resolved, COVID-19 (COVID-19) had resolved and DRUG INEFFECTIVE (Lack of drug effect) outcome was unknown.            Device date was reported as 15-May-2022.  Company Comment: This is a spontaneous case concerning a 50-year-old female patient with no relevant medical history, who experienced the unexpected, non-serious event of Drug Ineffective and two episodes of the unexpected non-serious adverse events of special interest, COVID-19 (COVID-19) which occurred on an unknown date after receiving the third dose of mRNA-1273 vaccine, and COVID-19 (reported as reported as "Rebound Covid after taking paxlovid") which occurred approximately 5 months after receiving the third dose of mRNA-1273. As reported, patient had rebound COVID after taking Paxlovid, no other clinical or treatment details were given. The benefit-risk relationship of mRNA-1273 Vaccine is not affected by this report. The events were considered related to the product per the reporter's assessment.; Sender's Comments: This is a spontaneous case concerning a 50-year-old female patient with no relevant medical history, who experienced the unexpected, non-serious event of Drug Ineffective and two episodes of the unexpected non-serious adverse events of special interest, COVID-19 (COVID-19) which occurred on an unknown date after receiving the third dose of mRNA-1273 vaccine, and COVID-19 (reported as reported as "Rebound Covid after taking paxlovid") which occurred approximately 5 months after receiving the third dose of mRNA-1273. As reported, patient had rebound COVID after taking Paxlovid, no other clinical or treatment details were given. The benefit-risk relationship of mRNA-1273 Vaccine is not affected by this report. The events were considered related to the product per the reporter's assessment.