Massive heart attack; blood clot; Pulmonary embolism; This spontaneous case was reported by a consumer and describes the occurrence of MYOCARDIAL INFARCTION (Massive heart attack), THROMBOSIS (blood clot) and PULMONARY EMBOLISM (Pulmonary embolism) in a 50-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 039a21a and 027ia21a) for COVID-19 vaccination.     No Medical History information was reported.   On 05-Mar-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 02-Apr-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 08-Apr-2021, the patient experienced MYOCARDIAL INFARCTION (Massive heart attack) (seriousness criteria death and medically significant), THROMBOSIS (blood clot) (seriousness criteria death and medically significant) and PULMONARY EMBOLISM (Pulmonary embolism) (seriousness criteria death and medically significant). The patient died on 08-Apr-2021. The reported cause of death was massive heart attack, Pulmonary embolism and blood clot. An autopsy was not performed.            No concomitant medications were reported. 6 days after the second dose the patient had a massive heart attack a blood clot pulmonary embolism, and died in three hours. The patient did not have allergies. The patient never had COVID positive test or diagnosis. The patient did not experience any medical history relating to mentioned AE and both acute and chronic illnesses at the time of vaccination. The patient did not receive other vaccines within 1 month prior to Moderna COVID-19 vaccine. The patient did not experience a similar event in the past and no history heart disease. The symptoms were not improved or worsened.   No treatment information was reported.  Company Comment: This spontaneous case concerns a 50-year-old old female patient with no medical history reported who experienced the fatal, unexpected, serious (medically significant) adverse events of special interest of Myocardial infarction, Thrombosis and Pulmonary embolism which occurred six days after receiving the second dose of mRNA-1273 vaccine. It was reported that patient had a massive heart attack a blood clot pulmonary embolism and died after three hours. Information about the clinical presentation, diagnostic evaluation and treatment details was not reported in this case. Death occurred six days after receiving the second dose of mRNA-1273 vaccine. The cause of death was reported as Myocardial infarction, Pulmonary embolism, and Thrombosis. Autopsy was not performed. The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report.; Sender's Comments: This spontaneous case concerns a 50-year-old old female patient, with no medical history reported who experienced the fatal, unexpected, serious (medically significant) adverse events of special interest of Myocardial infarction, Thrombosis and Pulmonary embolism which occurred six days after receiving the second dose of mRNA-1273 vaccine. It was reported that patient had a massive heart attack a blood clot pulmonary embolism and died after three hours. Information about the clinical presentation, diagnostic evaluation and treatment details was not reported in this case. Death occurred six days after receiving the second dose of mRNA-1273 vaccine. The cause of death was reported as Myocardial infarction, Pulmonary embolism, and Thrombosis. Autopsy was not performed. The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report.; Reported Cause(s) of Death: Massive heart attack; Pulmonary embolism; blood clot