some bruising on her left wrist/ bruise as a red blotchy patch, like a hive mark, but not raised "heading down" from her forearm to her hand; forearm and hand are a little warm to the touch; forearm and hand are a little warm to the touch; headache; nauseous; possible having a fever around 100 degrees Fahrenheit; tingling in her left hand; her fingers became tight/fingers so tight they can barely bend; numbnes in left hand/ hand was numb/ numbness in her left hand wore off; left hand began to swell and continued to swell throughout the day/ her hand was swollen again/her left hand is twice the size it was/left hand three times the size of right hand; This spontaneous case was reported by a consumer and describes the occurrence of HYPOAESTHESIA (numbnes in left hand/ hand was numb/ numbness in her left hand wore off), PARAESTHESIA (tingling in her left hand), PERIPHERAL SWELLING (left hand began to swell and continued to swell throughout the day/ her hand was swollen again/her left hand is twice the size it was/left hand three times the size of right hand), MUSCULOSKELETAL STIFFNESS (her fingers became tight/fingers so tight they can barely bend) and CONTUSION (some bruising on her left wrist/ bruise as a red blotchy patch, like a hive mark, but not raised "heading down" from her forearm to her hand) in a 46-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 024C21A and 017C21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     Concurrent medical conditions included Penicillin allergy. Concomitant products included BUPRENORPHINE HYDROCHLORIDE, NALOXONE HYDROCHLORIDE (BUPRENORPHINE/NALOXONE) for an unknown indication.   On 15-May-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 12-Jun-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. On 13-Jun-2021, the patient experienced HYPOAESTHESIA (numbnes in left hand/ hand was numb/ numbness in her left hand wore off) and PERIPHERAL SWELLING (left hand began to swell and continued to swell throughout the day/ her hand was swollen again/her left hand is twice the size it was/left hand three times the size of right hand). On 14-Jun-2021, the patient experienced PARAESTHESIA (tingling in her left hand) and MUSCULOSKELETAL STIFFNESS (her fingers became tight/fingers so tight they can barely bend). On 16-Jun-2021, the patient experienced CONTUSION (some bruising on her left wrist/ bruise as a red blotchy patch, like a hive mark, but not raised "heading down" from her forearm to her hand), FEELING HOT (forearm and hand are a little warm to the touch), HEADACHE (headache), NAUSEA (nauseous) and PYREXIA (possible having a fever around 100 degrees Fahrenheit). 16-Jun-2021, the patient experienced SKIN WARM (forearm and hand are a little warm to the touch). The patient was treated with IBUPROFEN at an unspecified dose and frequency. At the time of the report, HYPOAESTHESIA (numbnes in left hand/ hand was numb/ numbness in her left hand wore off), PARAESTHESIA (tingling in her left hand), PERIPHERAL SWELLING (left hand began to swell and continued to swell throughout the day/ her hand was swollen again/her left hand is twice the size it was/left hand three times the size of right hand), MUSCULOSKELETAL STIFFNESS (her fingers became tight/fingers so tight they can barely bend), CONTUSION (some bruising on her left wrist/ bruise as a red blotchy patch, like a hive mark, but not raised "heading down" from her forearm to her hand), SKIN WARM (forearm and hand are a little warm to the touch), FEELING HOT (forearm and hand are a little warm to the touch), HEADACHE (headache), NAUSEA (nauseous) and PYREXIA (possible having a fever around 100 degrees Fahrenheit) outcome was unknown.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On 16-Jun-2021, Body temperature: 100 (High) 100 degree farenheit.     For mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular), the reporter did not provide any causality assessments.   Treatment given included ACE bandage.