Headache; Nausea; Myalgias; Fatigue; Low grade fever; This spontaneous case was reported by a physician and describes the occurrence of HEADACHE (Headache), NAUSEA (Nausea), MYALGIA (Myalgias), FATIGUE (Fatigue) and PYREXIA (Low grade fever) in a 66-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination.     The patient's past medical history included Acne (took tetracycline for acne) in 1969, Diverticulitis in 2004, Hiatus hernia in 2004, Cough, Tonsillectomy in 1964, Laparoscopy in 1994, Female sterilisation in 1995, Colonoscopy on 07-Aug-2016 and Oesophagogastroduodenoscopy on 07-Aug-2016. Family history included Sjogren's syndrome since 1994 and Osteoarthritis (Mother, maternal grandmother, maternal grandfeather) since 2015. Concurrent medical conditions included Migraine (family history of migraine (mother, maternal grandmother, sister and son)) since 1970, Depression since 1996, Gastrooesophageal reflux since 2004, Osteopenia since 2006, Menopausal symptoms since 2006, Raynaud's phenomenon since 2008, Systemic scleroderma (Progressive or Diffuse;) since 2010, Supraventricular extrasystoles since 2013, Rhinitis allergic since 2015, Intervertebral disc degeneration since 2015, Radiculopathy since 18-Apr-2016, Diastolic dysfunction since 2016, Interstitial lung disease since 2018, Dyspnoea since 2018, Pulmonary arterial hypertension (RA associated with systemic sclerosis (scleroderma)) since 27-Nov-2018, Scleroderma since 03-Dec-2019, Headache since 2021, Constipation, Pulmonary hypertension, Non-tobacco user, Alcoholic (2 glass of wine (2 standard drink or equivalent) per week), Drug hypersensitivity (Rituxan (rituximab) allergy led to angioedema, chills, joints pain, shortness of breath and headache), Pyrexia, Pain, Caffeine consumption (Rarely) and Basedow's disease since 1994. Concomitant products included CICLOSPORIN (RESTASIS) from 1994 to an unknown date, FISH OIL (FISH OIL OMEGA 3) from 2004 to an unknown date, CALCIUM CARBONATE, COLECALCIFEROL (CALCIUM CARBONATE WITH D3) from 2015 to an unknown date, DICLOFENAC SODIUM (VOLTAREN ACTIGO [DICLOFENAC SODIUM]) from 2015 to an unknown date, FLUTICASONE PROPIONATE (FLONASE [FLUTICASONE PROPIONATE]) from 2015 to an unknown date, LIDOCAINE (LIDODERM) from 2017 to an unknown date, MYCOPHENOLATE MOFETIL (CELLCEPT [MYCOPHENOLATE MOFETIL]) from 2017 to an unknown date, METOPROLOL TARTRATE (LOPRESSOR) from 27-Aug-2018 to an unknown date, AZELASTINE HYDROCHLORIDE (ASTELIN [AZELASTINE HYDROCHLORIDE]) from 14-Oct-2019 to an unknown date, DENOSUMAB from 11-Apr-2019 to an unknown date, FAMOTIDINE (PEPCID [FAMOTIDINE]) from 23-Sep-2019 to an unknown date, LISINOPRIL from 16-Aug-2016 to 18-Jul-2019, MACROGOL 3350 (MIRALAX) from 20-Jan-2020 to an unknown date, SALBUTAMOL SULFATE (ALBUTEROL [SALBUTAMOL SULFATE]) from 24-Jun-2021 to an unknown date, AZITHROMYCIN (ZITHROMAX) from 22-Jul-2021 to an unknown date, DEXLANSOPRAZOLE (DEXILANT) from 24-Jun-2021 to an unknown date, FUROSEMIDE (LASIX [FUROSEMIDE]) from 03-Aug-2021 to an unknown date, GABAPENTIN (NEURONTIN) from 03-Aug-2021 to an unknown date, LOPERAMIDE HYDROCHLORIDE (IMODIUM A-D) from 08-Sep-2021 to an unknown date, MACITENTAN (OPSUMIT) from 05-Jul-2021 to an unknown date, MULTIVITAMIN WITH MINERALS TABLETS (29) from 16-Jan-2021 to an unknown date, TADALAFIL (ADCIRCA) from 05-May-2021 to an unknown date, TRAMADOL HCL from 20-Aug-2021 to an unknown date, PARACETAMOL (TYLENOL) from 2021 to an unknown date, CELECOXIB, NINTEDANIB, ONDANSETRON HYDROCHLORIDE (ZOFRAN [ONDANSETRON HYDROCHLORIDE]) and BOSWELLIA SERRATA RESIN, CURCUMA LONGA ROOT, GLUCOSAMINE HYDROCHLORIDE (OSTEO BI-FLEX JOINT HEALTH TRIPLE STRENGTH + TURMERIC) from 2019 to an unknown date for an unknown indication.    On an unknown date, the patient received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On an unknown date, the patient experienced HEADACHE (Headache), NAUSEA (Nausea), MYALGIA (Myalgias), FATIGUE (Fatigue) and PYREXIA (Low grade fever). At the time of the report, HEADACHE (Headache), NAUSEA (Nausea), MYALGIA (Myalgias), FATIGUE (Fatigue) and PYREXIA (Low grade fever) outcome was unknown. Not Provided      For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown), the reporter did not provide any causality assessments.   No treatment information is provided   This case was linked to MOD-2021-328358 (Patient Link).