ACUTE MACULAR NEURORETINOPATHY; This spontaneous report was received from literature. This report concerned a 26 year old female. The objective of this study was to present the rare case of a patient who developed acute macular neuroretinopathy following administration of a single dose adenovector coronavirus vaccine The patient's height, and weight were not reported. The patient's other pre-existing medical conditions included: Patient was healthy female with no previous medical or ocular history. Patient had previously received seasonal influenza immunization without any symptoms and denied any recent history of viral illnesses. Patient denied any other medication use or recent changes in diet and she also denied any history of hypertension, trauma, hypovolemia, or epinephrine use. The patient took oral contraceptives (for past 8 years). The patient was previously treated with diphtheria vaccine toxoid/hib vaccine/pertussis vaccine/tetanus vaccine toxoid for immunization.  The patient received covid-19 vaccine ad26.cov2.s (suspension for injection, route of admin not reported, batch number: Unknown) dose, 1 total, start therapy date were not reported for prophylactic vaccination. Batch number was not reported and has been requested. No concomitant medications were reported.  On an unspecified date, the patient presented with a five day history of paracentral scotomas in both eyes. Patient reported that she received a single dose adenovector coronavirus vaccine two days prior to the onset of her symptoms. On examination, her best-corrected visual acuity was 20/20 in both eyes. It was reported that there was no afferent pupillary defect, and intraocular pressure was 18 in the right eye and 15 in the left eye. Slit-lamp biomicroscopy and ophthalmoscopic examination were unremarkable in both eyes. Fundus autofluorescence showed petalloid faintly hypoautofluorescent lesions in the right eye, while the left eye appeared normal. Spectral domain optical coherence tomography revealed focal areas of parafoveal hyperreflective bands in the outer retina in both eyes without retinal thickening. Near-infrared reflectance showed wedge-shaped parafoveal lesions pointing to the fovea that corresponded to these lesions. It was reported that the imaging findings were consistent with acute macular neuroretinopathy, and conservative management was recommended. Laboratory data (dates unspecified) included: COVID-19 virus test (NR: not provided) negative. The action taken with covid-19 vaccine ad26.cov2.s was not applicable. The outcome of acute macular neuroretinopathy was not reported. Authors discussed the development of acute macular neuroretinopathy after a SARS-CoV-2 vaccination in an otherwise healthy female patient. A single case cannot establish cause and effect, and millions of COVID-19 vaccines have been administered safely at the time of writing. However, this may be a rare association, and clinicians can consider inquiring about recent vaccination history in patients presenting with acute macular neuroretinopathy. This report was serious (Other Medically Important Condition).; Sender's Comments: V0: 20211012947- Covid-19 vaccine ad26.cov2.s-Acute macular neuroretinopathy. This event is considered unassessable. The event has a compatible/suggestive temporal relationship, is unlabeled, and has unknown scientific plausibility. There is no information on any other factors potentially associated with the event.