Had a fever; So tired, couldn't get out of bed; Small green blisters; Skin on face turns purple; burning pain around her eyes, mouth, on her chin and down the side of her face; Urinary tract infection (UTI); Swelling; Glands in her throat are swollen; Tired; Itching; This case was reported by a consumer via call center representative and described the occurrence of fever in a 56-year-old female patient who received Herpes zoster (Shingrix) for prophylaxis.   Co-suspect products included cefalexin (Cephalexin) for urinary tract infection.   The patient's past medical history included shingles (8 years before reporting). Previously administered products included shingrix with an associated reaction of pyrexia (received 1st dose on an unknown date and experienced fever and tiredness, refer case US2022006658).   On an unknown date, the patient received Shingrix and Cephalexin 500 mg twice daily (1000 mg daily). On 13th January 2022, less than 6 months after receiving Shingrix and an unknown time after starting Cephalexin, the patient experienced pruritus, swelling, lymphadenopathy cervical and tiredness. On an unknown date, the patient experienced fever, tiredness, blister, skin discoloration, pain burning and urinary tract infection. The patient was treated with muscle relaxants (Muscle Relaxant) and neosporin (nos) (Neosporin). The action taken with Cephalexin was unknown. On an unknown date, the outcome of the fever, tiredness and urinary tract infection were recovered/resolved and the outcome of the blister, skin discoloration, pruritus, pain burning, swelling and tiredness were not recovered/not resolved and the outcome of the lymphadenopathy cervical was unknown.   It was unknown if the reporter considered the fever, tiredness, blister, skin discoloration, pruritus, pain burning, urinary tract infection, swelling, lymphadenopathy cervical and tiredness to be related to Shingrix.     Linked case(s) involving the same patient:  US2022006658  Additional details were provided as follows: The reporter was the concerned patient. The patient received the second Shingrix dose about 6 months before reporting, same evening she had a fever and was so tired she couldn't get out of bed. The patient further stated, every two to three weeks since receiving the second dose, her face breaks out in small green blisters, the skin on her face turns purple and she has itching, burning pain around her eyes, mouth, on her chin and down the side of her face. The patient stated, since the second Shingrix dose she had burning pain in her back about every six weeks (AE: pain, not recovered). The back pain was treated with muscle relaxants. Last week from the day of reporting the patient developed a urinary tract infection which was treated with cephalexin 500mg bid for 5 days. She ran out of the cephalexin a night before reporting so she took her dog's cephalexin 500mg. On the day of reporting in the morning her face again has itching, burning pain, swelling, little green blisters, she's tired and the glands in her throat are swollen. She was treating the blisters with Neosporin. She had an appointment with a dermatologist on 19th January 2022. It was unknown if the reporter considered the fever, tiredness, blister, skin discoloration, pruritus, pain burning, urinary tract infection, swelling, lymphadenopathy cervical and tiredness to be related to Cephalexin. The reporter consented to follow up.; Sender's Comments:  US-GLAXOSMITHKLINE-US2022006658:Same reporter