little tired; very bad headache in the occipital area/It just felt like a really horrifically bad headache; Fatigue; Flu like symptoms; This is a spontaneous report received from contactable reporter(s) (Other HCP) from medical information team. The reporter is the patient.  A 71 year-old female patient received bnt162b2 (BNT162B2), administration date 27Sep2021 (Lot number: EW0186) at the age of 71 years as dose 3 (booster), single for covid-19 immunisation. Relevant medical history included: "Vitamin B12 low" (unspecified if ongoing); "Cholesterol " (unspecified if ongoing). Concomitant medication(s) included: VITAMIN B12 [CYANOCOBALAMIN] taken for vitamin b12 abnormal; STATIN [ATORVASTATIN CALCIUM] taken for blood cholesterol. Vaccination history included: Bnt162b2 (First injection given on 12Jan2021 and lot: EK9231), administration date: 12Jan2021, when the patient was 71 years old, for COVID-19 Immunization; Bnt162b2 (Second injection given on 29Jan2021 and lot: EL9261.), administration date: 29Jan2021, when the patient was 71 years old, for COVID-19 Immunization, reaction(s): "Headache", "First injection given on 12Jan2021 and lot: EK9231. Expiry: unknown. NDC: unknown. It was given in the Nursing Education Hall of the hospital. Second injection given on 29Jan2021 and lot: EL9261.", "First injection given on 12Jan2021 and lot: EK9231. Expiry: unknown. NDC: unknown. It was given in the Nursing Education Hall of the hospital. Second injection given on 29Jan2021 and lot: EL9261.". The following information was reported: HEADACHE (non-serious) with onset 27Sep2021, outcome "recovered" (28Sep2021), described as "very bad headache in the occipital area/It just felt like a really horrifically bad headache"; FATIGUE (non-serious) with onset Sep2021, outcome "unknown", described as "Fatigue"; INFLUENZA LIKE ILLNESS (non-serious) with onset Sep2021, outcome "unknown", described as "Flu like symptoms"; FATIGUE (non-serious) with onset 29Sep2021, outcome "unknown", described as "little tired". Relevant laboratory tests and procedures are available in the appropriate section. Therapeutic measures were taken as a result of headache.  Additional information: Caller questions how long side effects could last for her husband. Noting her side effects have resolved. He was getting better and was currently 48 hours post vaccination. Caller states her husband had received his flu vaccine as well as the 1st dose of the shingles vaccine 2 weeks prior to the COVID booster vaccine and questions if his symptoms may be possibly releated to this. Caller herself as well as her husband, both received their Pfizer COVID Booster dose on 27Sep2021. The caller is a 71-year-old female and her husband is a 72-year-old male. Caller reports having a very bad headache in the occipital area but states she has recovered from that and was fine. Although she does note the headache to have been really bad. Her husband who is also a Insulin Dependent Diabetic had a fever of over 101 with nausea and fatigue. The caller states he remains fatigued today and is currently laying down with a headache that was rated as a 3. The wife, also the caller, is and has been giving Tylenol to help manage his symptoms. She states she cleared up right away. He was getting better. Caller states with his high fevers he was incapacitated and notes his symptoms to have been quite debilitating and was out yesterday although today he is better. The husband also received his flu vaccine and 1st shingles vaccine 2 weeks ago. The caller is not sure if this could have precipitated the fevers he is experiencing. Caller says her husband got like a shingle type rash on the arm where his shingles vaccine was given. Vitamin B12 Injection: about once every 3 months because her B12 was low in 2016. It was good now. Caller states that she had a headache when she woke up yesterday. She felt it in the occipital area. She has a master's in mental health and felt like the top would blow off. It was 10 out of 10. It dissipated throughout the day. She is a little tired. Today, she took Tylenol. Headache: started on 27Sep2021 about 25 minutes after the injection. That happened when she had the second vaccine before, but it dissipated. She did not think much about it because it started after. She took Extra Strength Tylenol when she got home. During the night and wee hours of the morning around 4:30AM on 28Sep2021 it was 100 out of 10. It just felt like a really horrifically bad headache. She has annual bloodwork next week. Extra strength tylenol: lot number: AFA091, expiry: Apr2023, NDC:30043739. She does not have the box. Manufacturer: Tylenol Gelcaps. Count size: 100.  Follow-up attempts are completed. No further information is expected.