Paxolvid rebound. Sore throat came back on Saturday, May 20th. Tested negative on Friday and Saturday. Tested positive on Sunday for COVID. All rapid tests.; This spontaneous case was reported by a patient and describes the occurrence of COVID-19 (Paxolvid rebound. Sore throat came back on Saturday, May 20th. Tested negative on Friday and Saturday. Tested positive on Sunday for COVID. All rapid tests.) in a 41-year-old male patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 014F21A, 032M20A and 039K20A) for COVID-19 vaccination.     Patient previously received a COVID-19 Vaccine.  Concurrent medical conditions included Drug allergy (Sensitivity to NSAIDS).   On 07-Feb-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 08-Mar-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 09-Nov-2021, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 21-May-2022, the patient experienced COVID-19 (Paxolvid rebound. Sore throat came back on Saturday, May 20th. Tested negative on Friday and Saturday. Tested positive on Sunday for COVID. All rapid tests.). The patient was treated with NIRMATRELVIR, RITONAVIR (PAXLOVID) from 11-May-2022 to 16-May-2022 for COVID-19 treatment, at an unspecified dose and frequency. On 25-May-2022, COVID-19 (Paxolvid rebound. Sore throat came back on Saturday, May 20th. Tested negative on Friday and Saturday. Tested positive on Sunday for COVID. All rapid tests.) had resolved.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On 20-May-2022, SARS-CoV-2 test: negative (Negative) Negative. On 21-May-2022, SARS-CoV-2 test: negative (Negative) Negative. On 22-May-2022, SARS-CoV-2 test: positive (Positive) Positive.         No concomitant medications were reported. The patient previously received a COVID-19 Vaccine. The Paxolvid rebound. Sore throat came back on Saturday,20 May. Tested negative on Friday and Saturday. Tested positive on Sunday for COVID. All rapid tests. Company comment: This spontaneous case concerns a 41-year-old, male patient with no relevant medical history, who experienced the unexpected, non-serious of COVID-19. The event occurred 183 days after administration of third dose of mRNA-1273, the initial two doses of mRNA-1273 were given approximately 8 months prior, the interval between the two doses is 29 days. On May 11, 2022, patient was started on Nirmatrelvir and Paxlovid. It has been reported that the patient experienced sore throat on May 20, 2022, patient had a negative SARS-CoV-2 test on May 20 and 21, 2022, but yielded a positive result on May 22, 2022. Details of concomitant medications and clinical course were not provided. The benefit-risk relationship of mRNA-1273 is not affected by this report.; Sender's Comments: This spontaneous case concerns a 41-year-old, male patient with no relevant medical history, who experienced the unexpected, non-serious of COVID-19. The event occurred 183 days after administration of third dose of mRNA-1273, the initial two doses of mRNA-1273 were given approximately 8 months prior, the interval between the two doses is 29 days. On May 11, 2022, patient was started on Nirmatrelvir and Paxlovid. It has been reported that the patient experienced sore throat on May 20, 2022, patient had a negative SARS-CoV-2 test on May 20 and 21, 2022, but yielded a positive result on May 22, 2022. Details of concomitant medications and clinical course were not provided. The benefit-risk relationship of mRNA-1273 is not affected by this report.