Eczema flared up pretty badly/main areas affected were both her palms, hands, fingers and left foot, but it also cam u p above knee and arms; she broke both her middle fingers; Stress; This spontaneous case was reported by a consumer and describes the occurrence of ECZEMA (Eczema flared up pretty badly/main areas affected were both her palms, hands, fingers and left foot, but it also cam u p above knee and arms), HAND FRACTURE (she broke both her middle fingers) and STRESS (Stress) in a 65-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 prophylaxis.    Co-suspect product included non-company product DUPILUMAB injection for Atopic dermatitis.    Concurrent medical conditions included Eczema and Atopic dermatitis ("Atopic dermatitis (Dermatitis atopic)").   On 14-Nov-2019, the patient started DUPILUMAB (Subcutaneous) 600 mg, 1X, Subcutaneous. In March 2021, the patient received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. In July 2020, the patient experienced ECZEMA (Eczema flared up pretty badly/main areas affected were both her palms, hands, fingers and left foot, but it also cam u p above knee and arms) (seriousness criterion disability), HAND FRACTURE (she broke both her middle fingers) (seriousness criterion disability) and STRESS (Stress) (seriousness criterion disability). At the time of the report, ECZEMA (Eczema flared up pretty badly/main areas affected were both her palms, hands, fingers and left foot, but it also cam u p above knee and arms), HAND FRACTURE (she broke both her middle fingers) and STRESS (Stress) outcome was unknown.            This case was identified as part of a retrospective clean-up activity where certain emails received in the Moderna mailbox were missed to be booked-in.  No Concomitant and Treatment drug was provided by reporter.  Dupilumab was given 300mg QOW Subcutaneous with dates from 28Nov2019 to ongoing.   Patient had some good days and some  not so good days/ could not do chores and housework as both her palms like leather due to being flare up.  Consumer has been getting samples from her doctor and been giving her injection probably once a month and not every two weeks/ taking dupilumab on and off  Company Comment:  This is a spontaneous case, reported by a consumer, concerning a 65-year-old female patient with relevant medical condition of Atopic dermatitis/Eczema, who experienced the unexpected serious (disability) Eczema, Hand fracture, and Stress, which occurred approximately 8 months prior to a dose of mRNA-1273 as the second dose of COVID-19 vaccine (no information disclosed on previous COVID-19 vaccination). It was reported that because of the stress and not giving Dupilumab on a regular basis patient begins to have atopic dermatitis flare. Patient also reported that she broke her middle fingers. Three weeks post mRNA-1273 vaccination, her eczema flared up pretty badly. The main areas affected were both her palms, hands, fingers, and left foot, but it also came up above her knee and arms. Patient could not do her chores and housework as both her palms are like leather due to being flared up. No further details about the diagnostic procedures and treatments were provided. Outcome of the events were unknown. The medical condition of Atopic dermatitis/Eczema remains as a confounders for Eczema aggravated/flare up. Stress and non-compliance to Dupilumab administration could be the precipitating factor for Eczema flare up. The benefit-risk relationship of mRNA-1273 is not affected by this report.; Sender's Comments: This is a spontaneous case, reported by a consumer, concerning a 65-year-old female patient with relevant medical condition of Atopic dermatitis/Eczema, who experienced the unexpected serious (disability) Eczema, Hand fracture, and Stress, which occurred approximately 8 months prior to a dose of mRNA-1273 as the second dose of COVID-19 vaccine (no information disclosed on previous COVID-19 vaccination). It was reported that because of the stress and not giving Dupilumab on a regular basis patient begins to have atopic dermatitis flare. Patient also reported that she broke her middle fingers. Three weeks post mRNA-1273 vaccination, her eczema flared up pretty badly. The main areas affected were both her palms, hands, fingers, and left foot, but it also came up above her knee and arms. Patient could not do her chores and housework as both her palms are like leather due to being flared up. No further details about the diagnostic procedures and treatments were provided. Outcome of the events were unknown. The medical condition of Atopic dermatitis/Eczema remains as a confounders for Eczema aggravated/flare up. Stress and non-compliance to Dupilumab administration could be the precipitating factor for Eczema flare up. The benefit-risk relationship of mRNA-1273 is not affected by this report.