Melancholy; loss of sensation in fingers, almost like neuropathy; severe nightmare; sensitive mouth pain and sores; mouth sores; lips cracking open on the edge; spots on arm, legs, tips of finger, foot; did not have energy, melancholy, feeling like in a dark cloud; Intense pain in right leg, foot, arm; exacerbated nerve pain; Numbness on right finger; Loss of taste; felt like mouth, gums, cheeks and tongue was set on fire; feeling like in a dark cloud/extremely noxious; This spontaneous case was reported by a consumer and describes the occurrence of MAJOR DEPRESSION (Melancholy), SENSORY LOSS (loss of sensation in fingers, almost like neuropathy), NIGHTMARE (severe nightmare), ORAL PAIN (sensitive mouth pain and sores) and STOMATITIS (mouth sores) in a male patient of an unknown age who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 005CZHA and 0Z8AZ1A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     The patient's past medical history included Post herpetic neuralgia and Ophthalmic herpes zoster. Concomitant products included HYDROCODONE BITARTRATE, PARACETAMOL (NORCO) for Pain, DULOXETINE HYDROCHLORIDE (CYMBALTA) for an unknown indication.   On 29-Mar-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 03-May-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On an unknown date, the patient experienced MAJOR DEPRESSION (Melancholy), SENSORY LOSS (loss of sensation in fingers, almost like neuropathy), NIGHTMARE (severe nightmare), ORAL PAIN (sensitive mouth pain and sores), STOMATITIS (mouth sores), CHAPPED LIPS (lips cracking open on the edge), PIGMENTATION DISORDER (spots on arm, legs, tips of finger, foot), ASTHENIA (did not have energy, melancholy, feeling like in a dark cloud), PAIN IN EXTREMITY (Intense pain in right leg, foot, arm), NEURALGIA (exacerbated nerve pain), HYPOAESTHESIA (Numbness on right finger), AGEUSIA (Loss of taste), ORAL DISCOMFORT (felt like mouth, gums, cheeks and tongue was set on fire) and FEELING ABNORMAL (feeling like in a dark cloud/extremely noxious). The patient was treated with GABAPENTIN for Neuropathic pain, at a dose of 1 dosage form. At the time of the report, MAJOR DEPRESSION (Melancholy), NIGHTMARE (severe nightmare), ORAL PAIN (sensitive mouth pain and sores), STOMATITIS (mouth sores), CHAPPED LIPS (lips cracking open on the edge), ASTHENIA (did not have energy, melancholy, feeling like in a dark cloud), NEURALGIA (exacerbated nerve pain), ORAL DISCOMFORT (felt like mouth, gums, cheeks and tongue was set on fire) and FEELING ABNORMAL (feeling like in a dark cloud/extremely noxious) outcome was unknown, SENSORY LOSS (loss of sensation in fingers, almost like neuropathy), PIGMENTATION DISORDER (spots on arm, legs, tips of finger, foot), PAIN IN EXTREMITY (Intense pain in right leg, foot, arm) and HYPOAESTHESIA (Numbness on right finger) had not resolved and AGEUSIA (Loss of taste) had resolved.            After receiving  both 1st and 2nd dose patient had the worst nightmare, all matters of death. After the 2nd dose, he developed loss of taste which is little resolved, very sensitive mouth pain and sores, felt like mouth, gums, cheeks and tongue was set on fire. He went to the dentist who gave something to put on the lips that were cracking open on the edge, mouthwash and anesthetic. He also developed loss of sensation in fingers, which was still persisting, almost like a neuropathy, spots on arms, legs, tips of fingers, and foot. His doctor prescribed gabapentin which helped a little, but still having the effect. He did not have energy, felt melancholy, like in a dark cloud for 5 to 7 days. He felt extremely noxious for no reason. He still gets intense pain in right leg, foot, arm and numbness in right fingers. He stated that he had herpes shingles in right eye and had post herpetic neuralgia from it. He suspected that the vaccine exacerbated the nerve pain. His doctor told him not to receive the booster shot because of the reactions he experienced. Treatment included mouthwash, anesthetic for mouth pain. Company comment: This is a Spontaneous case concerning an unknown age, male patient with a history of Post herpetic neuralgia, who experienced the  non-serious unexpected, according CCDS, AESI of Ageusia and the non-serious unexpected, according CCDS, events of Major depression, sensory loss, Nightmare, oral pain, stomatitis, chapped lips, pigmentation disorder, asthenia, neuralgia , hypoaesthesia, oral discomfort, feeling abnormal. The events occurred after the second dose of mRNA-1273 vaccine. The rechallenge was not applicable since the events happened after the second dose. The medical history of Post herpetic neuralgia, remains as a confounder. The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report.   This case was linked to MOD-2021-433375 (Patient Link). Sender's Comments: This is a Spontaneous case concerning an unknown age, male patient with a history of Post herpetic neuralgia, who experienced the  non-serious unexpected, according CCDS, AESI of Ageusia and the non-serious unexpected, events of Major depression, sensory loss, Nightmare, oral pain, stomatitis, chapped lips, pigmentation disorder, asthenia, neuralgia , hypoaesthesia, oral discomfort, feeling abnormal. The events occurred after the second dose of mRNA-1273 vaccine. The rechallenge was not applicable since the events happened after the second dose. The medical history of Post herpetic neuralgia, remains as a confounder. The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report.