platelets have been going back up the right direction/vaccine seems to be sending me into remission at this time/somehow this is reversing my blood disorder/mRNA works with the autoimmune system; This spontaneous case was reported by an other health care professional and describes the occurrence of THERAPEUTIC RESPONSE UNEXPECTED (platelets have been going back up the right direction/vaccine seems to be sending me into remission at this time/somehow this is reversing my blood disorder/mRNA works with the autoimmune system) in a 68-year-old male patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 003K212A, X17E21A, 028L20A and 012C20A) for COVID-19 vaccination.     Concurrent medical conditions included Immune thrombocytopenic purpura.   On 25-Jan-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 22-Feb-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 18-Aug-2021, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 03-Mar-2022, received fourth dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On an unknown date, the patient experienced THERAPEUTIC RESPONSE UNEXPECTED (platelets have been going back up the right direction/vaccine seems to be sending me into remission at this time/somehow this is reversing my blood disorder/mRNA works with the autoimmune system). At the time of the report, THERAPEUTIC RESPONSE UNEXPECTED (platelets have been going back up the right direction/vaccine seems to be sending me into remission at this time/somehow this is reversing my blood disorder/mRNA works with the autoimmune system) outcome was unknown.        For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown), the reporter did not provide any causality assessments.   No concomitant medication details was reported. No treatment medication details was reported.  It was reported that The patient (in the past) developed immune thrombocytopenic purpura, which means he was susceptible to bleeding internally and externally. He was managed it for 15-20 years. He vaccinated with Moderna primary series and boosters. His platelets have been going back up the right direction, especially after getting the boosters. He 's been a physically fit guy. The only thing he can come up with was that the mRNA works with the autoimmune system. He thought that somehow this was reversing his blood disorder. He stated if this was correct, this could be huge for people. The vaccine seems to be sending him into remission at this time. He could furnish CBC results going back a long way as well as the results after he got his boosters if safety team would like. His platelets were almost up to a normal level. He had no other medical conditions, and the Moderna vaccines have been the only variable in his life. He's used to paying close attention to his body, so he would bet a lot of money that this was the cause of increasing his platelets. He explains that people of his condition pay thousands of dollars for medications like IgG. Patient ever had COVID-19.