lost so much weight; she got to him as quick as she could, and he was starting to fall; He sleeps a lot; felt like passing out; tired; didn't sleep good at all that night; got disoriented; Cold symptoms; Headache; runny nose and kind of sniffy; This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP).  A 74-year-old male patient received BNT162b2, BNT162b2 omi ba.4-5 (BNT162B2, BNT162B2 OMI BA.4-5), on 18Oct2022 at 09:20 as dose 4 (booster), single (Lot number: 6H9697) at the age of 74 years for covid-19 immunisation. The patient's relevant medical history included: "Chondrosarcoma", start date: 2008 (unspecified if ongoing), notes: bone cancer.; "gliosis scarring vascular dementia" (unspecified if ongoing); "acid reflux and stomach problems" (ongoing); "acid reflux and stomach problems" (ongoing); "Depression" (unspecified if ongoing); "memory loss/takes longer for him to think" (ongoing); "shoulder problems" (unspecified if ongoing), notes: has shoulder problems. The patient's relevant medical history included: "Chondrosarcoma"(bone cancer. they took it out all surgically and no radiation and was cancer free, but he has a little think on his lung, and they said it can come back any place at any time), start date: 2008 (unspecified if ongoing), notes: bone cancer.; "gliosis scarring vascular dementia" (unspecified if ongoing); "acid reflux and stomach problems" (ongoing); "acid reflux and stomach problems" (ongoing); "Depression" (unspecified if ongoing); "memory loss/takes longer for him to think" (ongoing); "shoulder problems" (unspecified if ongoing), notes: has shoulder problems. Concomitant medication(s) included: OMEPRAZOLE taken for gastroesophageal reflux disease started taking about 7 years ago, abdominal discomfort (ongoing); SERTRALINE oral taken for depression started taking about 15 years ago. he is doing fantastic now; MEMANTINE oral taken for amnesia they thought because of his memory loss but he has a hard, just takes longer for him to think. he will say give me a minute I just lost it, start date: Jun2022 (ongoing); VITAMIN B12 [CYANOCOBALAMIN] has been taking a long time, about 40 years for health stuff (ongoing).Vaccination history included: BNT162b2 (Dose1, single, Lot 9264), administration date: 03Feb2021, when the patient was 72-year-old, for Covid-19 immunization; BNT162b2 (Dose2, single, Lot EN6200), administration date: 24Feb2021, when the patient was 72-year-old, for Covid-19 immunization; BNT162b2 (DOSE 3 (BOOSTER), SINGLE, Lot: FC3183), administration date: 02Oct2021, when the patient was 73-year-old, for Covid-19 immunization. The following information was reported: NASOPHARYNGITIS (non-serious) with onset Oct2022, outcome "unknown", described as "Cold symptoms"; HEADACHE (non-serious) with onset Oct2022, outcome "unknown"; RHINORRHOEA (non-serious) with onset Oct2022, outcome "unknown", described as "runny nose and kind of sniffy"; DISORIENTATION (non-serious) with onset 19Oct2022 at 01:00, outcome "unknown", described as "got disoriented"; SOMNOLENCE (non-serious) with onset 19Oct2022 at 02:00, outcome "unknown", described as "He sleeps a lot"; INSOMNIA (non-serious) with onset 19Oct2022 at 02:00, outcome "unknown", described as "didn't sleep good at all that night"; SYNCOPE (medically significant) with onset 19Oct2022 at 02:00, outcome "recovering", described as "felt like passing out"; FALL (non-serious) with onset 19Oct2022 at 02:00, outcome "unknown", described as "she got to him as quick as she could, and he was starting to fall"; FATIGUE (non-serious) with onset 19Oct2022 at 02:00, outcome "unknown", described as "tired"; WEIGHT DECREASED (non-serious), outcome "unknown", described as "lost so much weight". The patient underwent the following laboratory tests and procedures: Weight: lost, notes: lost an awful lot of weight since being sick. Therapeutic measures were taken as a result of headache.   Clinical course: Patient lost an awful lot of weight since being sick. Patient's wife stated that she has never felt like passing out, like wanting to just drop. It happened to her and her husband. They didn't sleep good at all that night. At 2am she was in her chair and her husband got up to go to the bathroom and she heard him so oh no and she got to him as quick as she could, and he was starting to fall. His arm was stretched across the sink. He does have something on his brain that is shutting off blood circulation. He felt like his legs were giving out and his whole arm was on the sink, and he was dropping. She helped him get down to the floor because he felt like he was going to pass out. They sat for a little while and got their bearings. She told him they could crawl to the bedroom when they could. He has never had these symptoms before. He is very very tired and is currently sleeping and has been for a few hours. Both she and her husband had no fever. They were cold, weak or tired. Felt like they wanted to keep passing out their legs kept giving out. Thinks the feeling of passing out seems improved but isn't sure because he is sleeping. About 1am he got disoriented but he has a thing on his brain that is making him get like that sometimes. He was diagnosed not that long ago. Clarifies he was diagnosed before his Covid 19 vaccines. He sleeps a lot. He has vascular dementia that is called gliosis scarring on his brain. He has shoulder problems to begin with and he would have broken his shoulder if he fell. He got up to go to the bathroom and was washing his hands and he said oh no oh no and she got to him. Has been very tired since midnight that same night, the same day as his shot. He sleeps a lot. He had cold symptoms like a runny nose and kind of sniffy. He gets headaches with the other thing too, but he kept asking if she had a headache and she said yes you get a headache like you do with a head cold. He had 2 Tylenol this morning around 7am. Doesn't know how he is doing as he is sleeping. States he is not doing good, he has lost so much weight and she feeds him all the time and yesterday he kept saying to call Pfizer and let them know and she couldn't pick up a phone to call. They got the booster dose at 9:20am and about 10 hours later they started feeling like passing out. The adverse event does not require an Emergency Room visit and Physician Office visit. Patient did not receive any other vaccinations prior to the vaccinations within 4 weeks. Family and medical history was unknown. No relevant tests are performed.