joint of her right thumb blew up (increased in size); Bone of her wrist blew up (increased in size) about half an inch; It (arthritis) attached her neck/back and now it is stuck in her left knee; Barely work/Missed work for a week; This case was received via an unknown source (no reference has been entered for a health authority or license partner) on 03-Jan-2022 and was forwarded to Moderna on 03-Jan-2022.    This spontaneous case was reported by a consumer (subsequently medically confirmed) and describes the occurrence of JOINT SWELLING (joint of her right thumb blew up (increased in size)), BONE SWELLING (Bone of her wrist blew up (increased in size) about half an inch), ARTHRITIS (It (arthritis) attached her neck/back and now it is stuck in her left knee) and IMPAIRED WORK ABILITY (Barely work/Missed work for a week) in a 64-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination.     Previously administered products included for Product used for unknown indication: Pfizer (1st dose (Pfizer) Lot- EN6208 Exp Date- 30JUN2021 ) on 12-Mar-2021 and Pfizer (2nd dose (Pfizer) Lot - EP7533 Exp Date- 31JUL2021 ) on 03-Apr-2021. Past adverse reactions to the above products included No adverse event with Pfizer and Pfizer.    On 15-Dec-2021, the patient received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. In December 2021, the patient experienced JOINT SWELLING (joint of her right thumb blew up (increased in size)), BONE SWELLING (Bone of her wrist blew up (increased in size) about half an inch), ARTHRITIS (It (arthritis) attached her neck/back and now it is stuck in her left knee) and IMPAIRED WORK ABILITY (Barely work/Missed work for a week). The patient was treated with PREDNISONE in December 2021 for Adverse event, at an unspecified dose and frequency and PARACETAMOL (TYLENOL ARTHRITIS) in December 2021 for Adverse event, at an unspecified dose and frequency. At the time of the report, JOINT SWELLING (joint of her right thumb blew up (increased in size)), BONE SWELLING (Bone of her wrist blew up (increased in size) about half an inch), ARTHRITIS (It (arthritis) attached her neck/back and now it is stuck in her left knee) and IMPAIRED WORK ABILITY (Barely work/Missed work for a week) had not resolved.            No concomitant medications was reported.  Patient stated that within 10 hours of getting the booster, her joint of her right thumb blew up (increased in size). In addition, the bone of her wrist blew up (increased in size) about half an inch, then it (arthritis) attached her neck, back and now it is stuck in her left knee. She can barely work and has missed work for a week. She spoke to her doctor last week and has been on Prednisone and over the counter arthritis Tylenol. She is still having the side effects, she wished she never took the vaccine and she is not happy. She did not have the vaccination card for her booster dose. Patient spoke to her doctor last week. She was still having the side effects.  Company comment: This case concerns a 64-year-old, female patient with no medical history reported, who experienced the unexpected non serious events of joint swelling, bone swelling, arthritis and impaired work ability. The events occurred in the same month after the third dose of mRNA-1273. As reported, within 10 hours of getting the booster, her joint of her right thumb blew up (increased in size). In addition, the bone of her wrist blew up (increased in size) about half an inch, then it (arthritis) attached her neck, back and now it is stuck in her left knee, as reported. She could barely work and has missed work for a week. The benefit-risk relationship of mRNA-1273 is not affected by this report.; Sender's Comments: This case concerns a 64-year-old, female patient with no medical history reported, who experienced the unexpected non serious events of joint swelling, bone swelling, arthritis and impaired work ability. The events occurred in the same month after the third dose of mRNA-1273. As reported, within 10 hours of getting the booster, her joint of her right thumb blew up (increased in size). In addition, the bone of her wrist blew up (increased in size) about half an inch, then it (arthritis) attached her neck, back and now it is stuck in her left knee, as reported. She could barely work and has missed work for a week. The benefit-risk relationship of mRNA-1273 is not affected by this report.