very sick; heart palpitations; all the glands in the neck, lymph glands in neck swelled up/lymphatic glands swollen; the patient thought she was having anaphylactic shock; stiff neck; neck swelled up; fever; Rapid heart rate; Exacerbated MS symptoms; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP) from medical information team. The reporter is the patient.  A 78-year-old female patient received bnt162b2 (BNT162B2), administered in arm left, administration date 07Mar2021 (Batch/Lot number: unknown) at the age of 78 years as dose 1, single for covid-19 immunisation. Relevant medical history included: "Multiple sclerosis" (ongoing), notes: diagnosed at age 35 years.; "Mitral valve prolapse syndrome" (ongoing), notes: Born with this, very pronounced heart murmur; "Gluten free diet" (unspecified if ongoing), notes: Has been gluten free for 44 years, that's how she survived.; "Dysautonomia" (unspecified if ongoing); "bad reaction to all vaccines" (unspecified if ongoing), notes: don't do well with vaccines.; "AFib" (unspecified if ongoing), notes: Controls AFib with 2 Magnesium maleate pills 2xday.; "heart murmur" (unspecified if ongoing); "heat sensitive" (unspecified if ongoing); "Gluten free diet" (unspecified if ongoing). Family history included: "Mitral valve prolapse syndrome" (unspecified if ongoing), notes: Both parents had this condition and pacemakers. Concomitant medication(s) included: NALTREXONE taken for hormone therapy, multiple sclerosis; VITAMIN C [ASCORBIC ACID] taken for temperature intolerance. Past drug history included: Zoloft, reaction(s): "gained 20lbs in 2 years". Vaccination history included: Flu shot (Flu shot 35 years ago made her sick), for Immunization, reaction(s): "Sick". The following information was reported: ANAPHYLACTIC SHOCK (medically significant) with onset 07Mar2021, outcome "recovered" (2021), described as "the patient thought she was having anaphylactic shock"; MULTIPLE SCLEROSIS RELAPSE (medically significant) with onset 2021, outcome "not recovered", described as "Exacerbated MS symptoms"; ILLNESS (non-serious) with onset 07Mar2021, outcome "recovered" (2021), described as "very sick"; PALPITATIONS (non-serious) with onset 07Mar2021, outcome "unknown", described as "heart palpitations"; LYMPHADENOPATHY (non-serious) with onset 07Mar2021, outcome "not recovered", described as "all the glands in the neck, lymph glands in neck swelled up/lymphatic glands swollen"; MUSCULOSKELETAL STIFFNESS (non-serious) with onset Mar2021, outcome "not recovered", described as "stiff neck"; SWELLING (non-serious) with onset 2021, outcome "unknown", described as "neck swelled up"; PYREXIA (non-serious) with onset 2021, outcome "unknown", described as "fever"; HEART RATE INCREASED (non-serious) with onset 2021, outcome "unknown", described as "Rapid heart rate". Therapeutic measures were taken as a result of anaphylactic shock, illness, palpitations, lymphadenopathy, musculoskeletal stiffness, swelling, pyrexia. Clinical course: The patient takes no multiple sclerosis medications and takes Vitamin C, keeps temperature down, had no colds or flus. The patient hasn't left the house in 2 years. During this period, everything has fallen apart, lost track of paperwork, money, bills, just sort of unplugged. Last friend passed away a year ago so does not even have anyone to talk to. The patient has mitral valve prolapse syndrome. Born with this, very pronounced heart murmur. Both parents had this condition and pacemakers. Controls AFib with 2 Magnesium maleate pills 2xday. Because of this and MS has to be careful with heart. Dysautonomia connected to this. Heart is fine, but chemicals get out of balance; because of that has opposite reactions to all drugs. Has been gluten free for 44 years, that's how she survived. It was reported that the patient left administering facility about 30 minutes after being administered first dose of Pfizer Covid vaccine. Further described as very sick, heart palpitations, thought would have a stroke. In her neck, all the glands in her neck, lymph glands in neck swelled up; she thought she was having anaphylactic shock and almost went back into the hospital to show them; but instead went home and gave self-treatment. Caller reported that the only treatment for this event was self-treatment with Vitamin D, Vitamin C, a little bit of enzyme and aspirin and it worked. She treated as anti-inflammatory and it worked. No other testing, treatment or medical interventions performed relative this event. Event improved, she still has stiff neck all these months later and lymphatic glands swollen which scares her to death. After the first dose, her lymph nodes and neck swelled up. She was afraid that she was having anaphylactic shock, but it didn't get that far. Her neck got so stiff that for a day or two after the shot she couldn't turn her head. She still has some stiffness, and her lymph nodes are still a little swollen. She ran a fever, and because of her pre-existing consisting conditions of mitral valve prolapse and MS, she is heat sensitive. Her whole body is so sensitive that she cannot live in a retirement home because they keep it so hot in there; she likes it cold. She treated the fever aggressively for 2 days, with vitamin C, lysine, and took 2 Aspirin daily for a couple of days; she also drank lots of water, rested, and stayed cool. Running a fever and getting over heated gave her a rapid heart rate and palpitations. She had exacerbated MS symptoms. She has a very abnormal body with dysautonomia, so she has reactions to a lot of medications. She was born with the dysautonomia, but it took them many years to figure out that she had it. There were no prior vaccinations (within 4 weeks).  The lot number for bnt162b2 was not provided and will be requested during follow up.