Sex: M
Vaccine: COVID19
Symptoms: Balance disorder, Chills, Feeling cold, Hypothalamo-pituitary disorder, Joint stabilisation
Clinical narrative: if could be affecting hypothalamus; Has a brace on his knee; 4-5 days chills; felt like he was going to freeze to death/Got cold in the shower; Pain in his left leg; He has difficult with balance. Worse it has ever been. Has to be very careful to keep from falling; Walked with a cane for 4-5 weeks; This is a spontaneous report received from a contactable reporter(s) (Physician) from medical information team.A 85 year-old male patient received bnt162b2 (COMIRNATY), administration date 23Feb2021 (Batch/Lot number: unknown) as dose 2, single for covid-19 immunisation. The patient's relevant medical history and concomitant medications were not reported. Vaccination history included: Bnt162b2 (First Dose), for COVID-19 immunization.The following information was reported: HYPOTHALAMO-PITUITARY DISORDER (medically significant), outcome "unknown", described as "if could be affecting hypothalamus";JOINT STABILISATION (medically significant), outcome "unknown", described as "Has a brace on his knee"; CHILLS (non-serious), outcome "unknown", described as "4-5 days chills"; FEELING COLD (non-serious), outcome "unknown", described as "felt like he was going to freeze to death/Got cold in the shower"; PAIN IN EXTREMITY (non-serious), outcome "unknown", described as "Pain in his left leg"; BALANCE DISORDER (non-serious), outcome "unknown", described as "He has difficult with balance. Worse it has ever been. Has to be very careful to keep from falling"; WALKING AID USER (non-serious), outcome "unknown", described as "Walked with a cane for 4-5 weeks". Therapeutic measures were taken as a result of joint stabilisation. clinical information: Second dose 23Feb2021. 4-5 days chills, felt like he was going to freeze to death. Pain in his left leg. These symptoms have not gotten better, still gets the chills. He was asking if this has been reported, He has difficult with balance. Worse it has ever been. Has to be very careful to keep from falling. Got cold in the shower. Asking if could be affecting hypothalamus. Walked with a cane for 4-5 weeks. Endure rehab. Has a brace on his knee and received a cortisone shot. Before dose he was walking 3-5 miles. Has seen providers at a medical facility. Some recommended he go to (name withheld). He states he can live with it, but wanted to report his findings. He requests escalation for further research on the duration of symptoms. The lot number for bnt162b2 was not provided and will be requested during follow up.; Sender's Comments: Based on the current available information and the plausible drug-event temporal association, a possible contributory role of the suspect product BNT162B2 to the development of events Hypothalamo-pituitary disorder and Joint stabilization cannot be excluded. The impact of this report on the benefit/risk profile of the Pfizer product is evaluated as part of Pfizer procedures for safety evaluation, including the review and analysis of aggregate data for adverse events. Any safety concern identified as part of this review, as well as any appropriate action in response, will be promptly notified to regulatory authorities, Ethics Committees, and Investigators, as appropriate.