Age: 0.5
Sex: M
Vaccine: DTAP, HEP, HIBV, OPV, DTAP, HEP, HIBV, IPV
Symptoms: Drug toxicity, Ear disorder, Faecal incontinence, Hypersensitivity, Laboratory test abnormal
Clinical narrative: Information has been received regarding a case in litigation concerning a male who on 10/8/96, 11/7/96 and 3/10/97 was vaccinated with the 1st, 2nd and 3rd doses of Hep-B, respectively. Concomitant therapy on 11/7/96, 1/7/97 and 3/10/97 included 1st, 2nd and 3rd doses of Hib, respectively. Other concomitant therapy on 11/7/96, 1/7/97 and 3/10/97 included 1st, 2nd and 3rd doses of poliovirus vaccines, respectively, and the 1st, 2nd and 3rd doses of DPT, respectively. Subsequently, he developed a "Pervasive Developmental Disorder not otherwise specified". It was also reported that the pt experienced an adverse event as a result of the mercury in the thimerosal-containing vaccinations that he received as an infant during the period from 10/96 through 10/98. It was alleged that he now suffers and in the future will suffer from the toxic neurological effects of mercury poisoning. On 2/00, the pt was referred for an evaluation of speech delay and audiological evaluation; his hearing and visual exams were normal. His developmental history noted that the pt appeared to be developing normally and talking normally until about 2 years of age. At that point, the family moved and the pt was taken out of daycare and has been cared for in the home by a nanny and his mother. The family noted that he simply stopped talking at around 2 years of age. He also stopped participating in the activity of letting his parents read a storybook to him. He had regained the language that he lost and has added some new words, but he is still quite delayed in his language for his age. He would lick things frequently and had some unusual play patterns. He tended to have limited food choices. It was reported that he displayed repetitive movements, his toilet training had been coming along well, but then stopped and his sleep was characterized by waking at nighttime. There were some delays in his fine motor skills. The impression of the medical director was, "The pt is a 3 1/2 year old boy with a history of severe language delay which he lost and slowly was regaining. In addition, he was repetitive and had unusual play patterns with stereotyped behaviors and his social interactions, although not severely delayed, are somewhat atypical". "These findings are consistent with a Pervasive Developmental Disorder:. "Since he scored so low on the (autism rating scale), I don't thing we could consider a dx of full blown Autism, but I do thing the findings are consistent with a PDD not otherwise specified." It was noted that the pt received the 4th doses of DPT and Hib on 3/6/98. On 3/6/98, the pt received the 1st dose of MMRII. On 9/23/97, the pt received the 1st dose of varicella virus vaccine live. On 9/23/97 and 6/6/97, the pt received the 1st and 2nd dose of tuberculin, respectively. Upon internal review, the pt's PDD NOS and toxic neurologic effects of mercury poisoning were considered to be "Other Important Medical Events". No further information is available. F/U this is an amended report/ The narrative and the pt age field have been updated to indicate that the pt is approximately 2 yrs old. All available medical records will be provided upon request. This is a corrected report as amended.  Follow up on 07/13/2003: "Follow up information received on 07/11/2003 provided clarification of Orimune lot numbers and Quality Assurance results.  An attorney alleged that a male child received series of Orimune, Engerix B, Tripedia, and Act-Hib vaccines along with Fluzone, MMRII, and Varivax vaccines from 10/08/1996 to 12/15/1998.  It is alleged that, as a result of the cumulative toxicity of the thimerosal contained in those vaccines, the child suffered, and "in the future will continue to suffer, from the toxic neurological effects of mercury poisoning."  A "Communication Evaluation" performed on 02/09/2000 returned a diagnosis of speech and language delay.  Mercury poisoning was considered medically important (OMIC).