Sex: F
Vaccine: VARZOS
Symptoms: Discomfort, Fatigue, Herpes zoster, Myalgia, Nausea
Clinical narrative: pain / aches; Nausea; Normal levels of discomfort; Mild muscle aches in neck and back; tiredness; This case was reported by a consumer and described the occurrence of pain in a 65-year-old female patient who received Herpes zoster (Shingrix) for prophylaxis.   The patient's past medical history included shingles (20 years ago), cytomegalovirus infection, chickenpox (recurring monthly for 25 years) and post-traumatic stress disorder. Previously administered products included Antiviral (took a few monthly doses of an antiviral to manage breakouts of Post-traumatic stress disorder (PTSD)).   On an unknown date, the patient received the 1st dose of Shingrix. On an unknown date, less than 2 months after receiving Shingrix, the patient experienced pain, nausea, discomfort, muscle pain and tiredness. The patient was treated with acyclovir. On an unknown date, the outcome of the pain, nausea, discomfort, muscle pain and tiredness were unknown.   It was unknown if the reporter considered the pain, nausea, discomfort, muscle pain and tiredness to be related to Shingrix.  Additional details were provided as follows: The age at vaccination was not reported. The patient received 1st dose of Shingrix vaccine resulted in the normal levels of discomfort, pain, aches, tiredness, and nausea. The patient's mother had rheumatoid arthritis (RA) the patient had the factor but it's not active. The patient had been battling recurring monthly trunk located chicken pox for 25 years after an initial stressful PTSD event for which the patient taken a few monthly doses of an antiviral to manage breakouts. Symptoms were lifting with medication for pain. She had recurrent viral attacks (Shingles) on right hip from a stressful event 20 years ago.  The patient was taking acyclovir to manage the outbreak as done for 20 years.  It was her hope the vaccine would prevent future breakouts since the acyclovir in her case seems like a life long medication.  It's odd, in her case it's almost a monthly occurrence about 30 days apart and also in between with added stress of any kind both physical and emotional. Most doctors were sort of baffled, her original diagnosis was cytomegalovirus for which the patient was told there was no cure. Following up with a specialist, she just looked at me and said he did not have that.  Her family Doctor prescribed acyclovir as a prophylaxis for breakouts but she only take it until symptoms disappear and until the next occurrence. She just thought it odd the vaccine, being recombant, through the severity of side effects ( she had the g3 level of all the side effects for 48 hours and then fortunately bounced back with the usual Shingles rash on her hip and back to taking acyclovir to manage as usual. It was her hope and prayer she never get a full blown event like the symptoms from the shot again after receiving the full vaccine or the actual severity of the classic Shingles, the type that wraps around the torso and effects the whole body.  The patient just hope that whatever she have eventually goes always completely. For tolerance in 2nd dose refer case US2020AMR211620.; Sender's Comments:  US-GLAXOSMITHKLINE-US2020AMR211620:same patient, 2nd dose