Sex: F
Vaccine: COVID19, COVID19
Symptoms: Mast cell activation syndrome, Pharyngeal swelling, SARS-CoV-2 test, Urticaria, Vomiting
Clinical narrative: 4 year cycle of intense Mast cell activation syndrome events; Had symptoms, but the frequency of the flares intensified immediately after the vaccinations, as did the intensity; Acute vomiting; Abdominal pain; Angioedema events; Hives; Swelling of the joints, throat and intestines; Swelling of the joints, throat and intestines; Swelling of the joints, throat and intestines; This is a spontaneous report received from a Consumer or other non HCP.  An adolescent female patient (not pregnant) received BNT162b2 (BNT162B2), as dose 2, single (Batch/Lot number: unknown), in right arm for covid-19 immunisation. The patient's relevant medical history included: "Mast cell activation syndrome" (ongoing). The patient had no known allergies. There were no concomitant medications. The patient did not received any other vaccine within four weeks and any other medications within two weeks of COVID vaccination. Vaccination history included: Bnt162b2 (DOSE 1, SINGLE, Anatomical location: right arm), for COVID-19 Immunisation. The following information was reported: MAST CELL ACTIVATION SYNDROME (disability), outcome "recovering", described as "4 year cycle of intense Mast cell activation syndrome events"; CONDITION AGGRAVATED (disability), outcome "recovering", described as "Had symptoms, but the frequency of the flares intensified immediately after the vaccinations, as did the intensity"; VOMITING (disability), outcome "recovering", described as "Acute vomiting"; ABDOMINAL PAIN (disability), outcome "recovering"; ANGIOEDEMA (disability), outcome "recovering", described as "Angioedema events"; URTICARIA (disability), outcome "recovering", described as "Hives"; JOINT SWELLING (disability), PHARYNGEAL SWELLING (disability), GASTROINTESTINAL OEDEMA (disability), outcome "recovering" and all described as "Swelling of the joints, throat and intestines". The events "4 year cycle of intense mast cell activation syndrome events", "had symptoms, but the frequency of the flares intensified immediately after the vaccinations, as did the intensity", "acute vomiting", "abdominal pain", "angioedema events", "hives" and "swelling of the joints, throat and intestines" required physician office visit and emergency room visit. The patient underwent the following laboratory tests and procedures: SARS-CoV-2 test: (Nov2023) Positive, notes: Nasal Swab. Therapeutic measures were taken as a result of mast cell activation syndrome, condition aggravated, vomiting, abdominal pain, angioedema, urticaria, joint swelling, pharyngeal swelling, gastrointestinal oedema which included Steroids, Regular zolaire shots, fluids, Benadryl. Clinical course: Patient had kicked off a 4 year cycle of intense mast cell activation syndrome events, requiring multiple ER (emergency room) visits, doctor's visits, acute vomiting, abdominal pain, angioedema events, hives, swelling of the joints, throat and intestines. Had symptoms, but the frequency of the flares intensified immediately after the vaccinations, as did the intensity. Prior to vaccination the patient was not diagnosed with COVID-19. The patient was tested for COVID post vaccination.  The information on the batch/lot number for BNT162b2 will be requested and submitted if and when received.