Sex: F
Vaccine: COVID19, COVID19, TDAP, VARZOS
Symptoms: Demyelination, Movement disorder, Nervous system disorder
Clinical narrative: Primary CNS Lymphoma; Can't get out of bed or walk without help; Minimal movement in left arm ad left leg; Can't get out of bed; Neurological disease with severe demyelination of the brain; This spontaneous case was reported by a consumer and describes the occurrence of DEMYELINATION (Neurological disease with severe demyelination of the brain) and CENTRAL NERVOUS SYSTEM LYMPHOMA (Primary CNS Lymphoma) in a female patient of an unknown age who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.    Co-suspect products included non-company products VARICELLA ZOSTER VACCINE RGE (CHO) (SHINGRIX) for Vaccination and DIPHTHERIA VACCINE TOXOID, PERTUSSIS VACCINE ACELLULAR, TETANUS VACCINE TOXOID (TDAP) for Vaccination.    No Medical History information was reported.   On 15-Feb-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 15-Mar-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 05-May-2021, the patient received first dose of VARICELLA ZOSTER VACCINE RGE (CHO) (SHINGRIX) (unknown route) 1 dosage form and first dose of DIPHTHERIA VACCINE TOXOID, PERTUSSIS VACCINE ACELLULAR, TETANUS VACCINE TOXOID (TDAP) (unknown route) 1 dosage form. On 14-Jun-2021, the patient experienced DEMYELINATION (Neurological disease with severe demyelination of the brain) (seriousness criterion medically significant), GAIT INABILITY (Can't get out of bed or walk without help), MOVEMENT DISORDER (Minimal movement in left arm ad left leg) and VACCINATION COMPLICATION (Can't get out of bed). On an unknown date, the patient experienced CENTRAL NERVOUS SYSTEM LYMPHOMA (Primary CNS Lymphoma) (seriousness criterion medically significant). At the time of the report, DEMYELINATION (Neurological disease with severe demyelination of the brain), CENTRAL NERVOUS SYSTEM LYMPHOMA (Primary CNS Lymphoma), GAIT INABILITY (Can't get out of bed or walk without help), MOVEMENT DISORDER (Minimal movement in left arm ad left leg) and VACCINATION COMPLICATION (Can't get out of bed) outcome was unknown.            Concomitant product use was not provided by the reporter.  Patient went to ER on 07-JUN-2021 and again on 14-JUN-2021.  No treatment information was provided.  Company comment: This case concerns a female patient with unknown age, who experienced Serious  unexpected events of Demyelination and Central nervous system lymphoma, which occurred  approximately 3 months  after vaccination with the 2nd dose of mRNA-1273 vaccine (Moderna Covid 19 Vaccine ) . The re-challenge is not applicable since no more additional doses will be administered. The benefit-risk relationship of mRNA-1273 Vaccine (Moderna Covid 19 Vaccine ) is not affected by this report.   Most recent FOLLOW-UP information incorporated above includes: On 08-Nov-2021: Follow up received contains patient details and event was updated.; Sender's Comments: This case concerns a female patient with unknown age, who experienced Serious  unexpected events of Demyelination and Central nervous system lymphoma, which occurred  approximately 3 months  after vaccination with the 2nd dose of mRNA-1273 vaccine (Moderna Covid 19 Vaccine ) . The re-challenge is not applicable since no more additional doses will be administered. The benefit-risk relationship of mRNA-1273 Vaccine (Moderna Covid 19 Vaccine ) is not affected by this report.