Sex: U
Vaccine: VARZOS, VARZOS
Symptoms: Eczema herpeticum, Herpes zoster, Rash, Rash pruritic, Vaccination failure
Clinical narrative: Suspected vaccination failure; Eczema Herpeticum; shingles; lost some focus in my right eye; rash on my face/my entire body broke out in a rash; entire body broke out in a rash and it itched constantly; This serious case was reported by a consumer via other manufacturer and described the occurrence of vaccination failure in a patient who received Herpes zoster (Shingles vaccine) for prophylaxis.   Co-suspect products included Herpes zoster (Shingles vaccine) for prophylaxis.   In NOV-2023, the patient received the 2nd dose of Shingles vaccine. In APR-2023, the patient received the 1st dose of Shingles vaccine. On an unknown date, an unknown time after receiving Shingles vaccine and Shingles vaccine, the patient experienced vaccination failure (Verbatim: Suspected vaccination failure) (serious criteria GSK medically significant), eczema herpeticum (Verbatim: Eczema Herpeticum) (serious criteria GSK medically significant), shingles (Verbatim: shingles), difficulty focusing eyes (Verbatim: lost some focus in my right eye), exanthema facial (Verbatim: rash on my face/my entire body broke out in a rash) and generalized pruritus (Verbatim: entire body broke out in a rash and it itched constantly). The patient was treated with prednisone, aciclovir (Zovirax), valaciclovir (Valacyclovir) and dupilumab (Dupixent). The outcome of the vaccination failure was unknown and the outcome of the eczema herpeticum and exanthema facial were resolving and the outcome of the shingles was not reported and the outcome of the difficulty focusing eyes was resolved and the outcome of the generalized pruritus was not resolved.   It was unknown if the reporter considered the vaccination failure, eczema herpeticum, shingles, difficulty focusing eyes, exanthema facial and generalized pruritus to be related to Shingles vaccine and Shingles vaccine.     The company considered the vaccination failure to be related to Shingles vaccine and Shingles vaccine. The company considered the eczema herpeticum to be unrelated to Shingles vaccine and Shingles vaccine. It was unknown if the company considered the shingles, difficulty focusing eyes, exanthema facial and generalized pruritus to be related to Shingles vaccine and Shingles vaccine.   Additional Information: GSK Receipt Date: 11-JUL-2024 The patient self-reported this case. The patient received the 1st and 2nd dose of Shingles vaccine and had immediately started reacting.  The patient was misdiagnosed and was given antibiotics and prednisone, then when that wore off, was given a more potent antibiotic and more prednisone from 1st February 2024 to 18th March 2024. Finally the patient lost some focus in his/her right eye and went to the emergency room (ER) and they gave patient an intravenous (IV) of Zovirax and an antiviral oral medication called valacyclovir that cured it up. But the ophthalmologist said patient had shingles, so the shingles shingles kept being the word thrown around.  The rash on his/her face cured, then in late April patient's entire body broke out in a rash and it itched constantly and asked no one could shingles and said no.  The ophthalmologist sent the patient to an allergist and which took months to get in with and who diagnosed his/her issue. He said the patient had eczema herpeticum, which was caused by an autoimmune overreaction from the shingles booster.  The patient was given two 600 ml injections of Dupixent shot yesterday and need to continue every two weeks for a few months. The patient felt slightly better today (during the reporting days) and his/her rash was somewhat better. The patient still had a slight itch. This case was considered as suspected vaccination failure since the details regarding the time to onset and laboratory confirmation of shingles were unknown at the time of reporting.; Sender's Comments: Vaccination failure is a listed event which is considered related to GSK Shingles vaccine.  Eczema herpeticum is an unlisted event which is considered unrelated to GSK Shingles vaccine.