Age: 80.0
Sex: F
Vaccine: COVID19
Symptoms: Condition aggravated, Demyelination, Gait inability, Inflammation, Magnetic resonance imaging
Clinical narrative: demyelination; activated rheumatoid; there is a lot of inflammation; couldn't walk; fingers and hands lock up; It seems to have activated her rheumatoid; This spontaneous case was reported by a consumer and describes the occurrence of DEMYELINATION (demyelination) and RHEUMATOID ARTHRITIS (activated rheumatoid) in an 80-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 011M20A and 013L20A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     Concurrent medical conditions included Rheumatoid arthritis. Concomitant products included CARVEDILOL, LOSARTAN, DULAGLUTIDE (TRULICITY), DAPAGLIFLOZIN PROPANEDIOL MONOHYDRATE (FARXIGA), GLIPIZIDE, LEVOTHYROXINE SODIUM (LEVOXYL), PRAVASTATIN and DULOXETINE HYDROCHLORIDE (CYMBALTA) for an unknown indication.   On 13-Jan-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 10-Feb-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. On an unknown date, the patient experienced DEMYELINATION (demyelination) (seriousness criterion medically significant), RHEUMATOID ARTHRITIS (activated rheumatoid) (seriousness criterion medically significant), INFLAMMATION (there is a lot of inflammation), GAIT INABILITY (couldn't walk), TRIGGER FINGER (fingers and hands lock up) and CONDITION AGGRAVATED (It seems to have activated her rheumatoid). The patient was treated with METHYLPREDNISOLONE (MEDROL [METHYLPREDNISOLONE]) at a dose of Prednisone 7 day Medrol pack for three rounds and ADALIMUMAB (HUMIRA) at an unspecified dose and frequency. At the time of the report, DEMYELINATION (demyelination), RHEUMATOID ARTHRITIS (activated rheumatoid), INFLAMMATION (there is a lot of inflammation), GAIT INABILITY (couldn't walk), TRIGGER FINGER (fingers and hands lock up) and CONDITION AGGRAVATED (It seems to have activated her rheumatoid) had not resolved.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On an unknown date, Magnetic resonance imaging: abnormal (abnormal) demyelination.     For mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular), the reporter did not provide any causality assessments.   Based on the current available information and temporal association between the use of the product and the start date of the events, a causal relationship cannot be excluded. However, patient's underlying disease and advanced age remains a contributory factor.   This case was linked to MOD-2021-083671 (Patient Link).   Most recent FOLLOW-UP information incorporated above includes: On 05-Aug-2021: Added Events Demyelination, rheumatoid arthritis, gait inability, trigger finger, , Added medical history rheumatoid arthritis, Added additional information in the I Narrative field and Added treatment information in product tab.; Sender's Comments: Based on the current available information and temporal association between the use of the product and the start date of the events, a causal relationship cannot be excluded. However, patient's underlying disease and advanced age remains a contributory factor.