Sex: M
Vaccine: ANTH, ANTH
Symptoms: Dyspnoea, Erythema, Fatigue, Headache, Mucosal discolouration
Clinical narrative: Severe adverse/allergic reaction; Paralysis; Severe fatigue; Heart was out of natural rhythm; Severe headaches; Severe breathing difficulty; Vomiting; Skin turned grey and was red and swollen; Fever; Chills; Knives were stabbing me all over my body; Diarrhea; Dizziness; Skin turned grey and was red and swollen; Skin turned grey and was red and swollen; Blurred vision; Muscle twitches; Brown urine; Clear/blood/green mucus poured non-stop out of nose; This case was retrieved from a VAERS download on 04MAR2022.  A 23-year-old male patient reported the have had a severe adverse/allergic reaction" (PT: Hypersensitivity) following the administration BioThrax (anthrax vaccine). The "skin turned grey and was red and swollen" (PT: Skin discolouration, PT:  Skin swelling, and PT: Erythema), had "severe breathing difficulty" (PT: Dyspnoea), "felt like knives were stabbing all over the body" (PT: Pain), had "fever" (PT: Pyrexia), "chills" (PT: Chills), "severe fatigue" (PT: Fatigue), "severe headaches" (PT: Headache), "blurred vision" (PT: Vision blurred), "heart was out of natural rhythm" (PT: Heart rate irregular), "paralysis" (PT: Paralysis), "muscle twitches" (PT: Muscle twitching), "clear/blood/green mucus poured non-stop out of nose" (PT: Rhinorrhoea), "dizziness" (PT: Dizziness), "vomiting" (PT: Vomiting), "brown urine" (PT: Chromaturia), "diarrhea" (PT: Diarrhoea) and .  On 20JUN1990, the patient received BioThrax (dose: 1). Lot number was not reported.  On 27JUN1990, the skin of the patient turned grey and was red and swollen, had severe breathing difficulty, felt like knives were stabbing him all over the body. The patient had a fever of 102.7 degrees Fahrenheit, chills, severe fatigue, severe headaches, blurred vision. His heart was out of natural rhythm. He had paralysis and muscle twitches. It was reported that mucus (clear/blood/green) poured non-stop out of his nose for a week. He had dizziness, vomiting, brown urine, and diarrhoea. Reportedly, the patient had a very severe adverse/allergic reaction after he received the Anthrax vaccine, which required hospitalization for 7 days.  The patient's medical history included Gulf War Syndrome, pains, joint pains, gastrointestinal issues, severe intermittent headaches, eye pains, intermittent blurred vision, vomiting, dizziness, psychosis/schizophrenia, stomach problems, fatigued, off balance, lack of coordination, high blood pressure, skin sensitivity issues and was allergic to anthrax vaccine.  His current illness and concomitant medications were reported as none.  Company comment: The reported age was probably recorded in error. The description of the events is confusing to proper assess the case. If the patient developed an allergic reaction, it would have been an anaphylaxis to be life threatening. most of the time anaphylaxis is immediate after triggering cause. It would be unusual to developed seven days after vaccination. The symptoms, rather describes a severe skin condition like Steven Johnson syndrome that usually is accompanied by systemic symptoms. Despite the lack of information, some of the symptoms are considered as possible related. Arrhythmia, rather coded as heart beat irregular, nasal discharge, chromaturia muscle twitching, vision blurred, and paralysis are not pathognomonic of hypersensitivity; therefore considered "unassessable".  The case is considered serious due to hypersensitivity (life threatening) and paralysis (disability), and the required hospitalization of the patient. Paralysis, arrhythmia, vomiting, dyspnoea, skin discolouration, vision blurred, muscle twitching, nasal mucosal discolouration, chromaturia, diarrhoea, and skin swelling are unlisted whereas hypersensitivity, erythema, chills, pain, pyrexia, headache, dizziness, and fatigue are listed as per BioThrax.; Sender's Comments: Company comment: The reported age was probably recorded in error. The description of the events is confusing to proper assess the case. If the patient developed an allergic reaction, it would have been an anaphylaxis to be life threatening. most of the time anaphylaxis is immediate after triggering cause. It would be unusual to developed seven days after vaccination. The symptoms, rather describes a severe skin condition like Steven Johnson syndrome that usually is accompanied by systemic symptoms. Despite the lack of information, some of the symptoms are considered as possible related. Arrhythmia, rather coded as heart beat irregular, nasal discharge, chromaturia muscle twitching, vision blurred, and paralysis are not pathognomonic of hypersensitivity; therefore considered "unassessable".  The case is considered serious due to hypersensitivity (life threatening) and paralysis (disability), and the required hospitalization of the patient. Paralysis, arrhythmia, vomiting, dyspnoea, skin discolouration, vision blurred, muscle twitching, nasal mucosal discolouration, chromaturia, diarrhoea, and skin swelling are unlisted whereas hypersensitivity, erythema, chills, pain, pyrexia, headache, dizziness, and fatigue are listed as per BioThrax.