Age: 54.0
Sex: F
Vaccine: COVID19, COVID19
Symptoms: Coagulation time, Coagulation time prolonged, Immunisation, Loss of personal independence in daily activities, Orthostatic hypertension
Clinical narrative: Malignant orthostatic HYPERtension with physical manifestation; unable to work, unable to perform routine daily activities; increased clotting time; Booster; This is a spontaneous report received from a contactable reporter(s) (Physician). The reporter is the patient.  A 54 year-old female patient (not pregnant) received bnt162b2 (BNT162B2), intramuscular, administered in arm left, administration date 17Sep2021 at 10:00 (Lot number: FC3184) at the age of 54 years as dose 3 (booster), single for covid-19 immunisation. Relevant medical history included: "thyroid" (unspecified if ongoing); "Mito" (unspecified if ongoing); "Known allergies: Sulfa, pineapple" (unspecified if ongoing); "Known allergies: Sulfa, pineapple" (unspecified if ongoing). No covid prior vaccination. The patient took concomitant medications in two weeks. No other vaccine in four weeks. Vaccination history included: Bnt162b2 (brand=Pfizer, lot number=EL0142, route=Intramuscular, time=03:00PM, dose number=2, location=Left arm,), administration date: 14Jan2021, when the patient was 54 years old, for Covid-19 immunization; Bnt162b2 (brand=Pfizer, lot number=EJ1685, route=Intramuscular, time=03:00PM, dose number=1, location=Left arm), administration date: 26Dec2020, for Covid-19 immunization. The following information was reported: IMMUNISATION (hospitalization, disability, life threatening) with onset 17Sep2021 10:00, outcome "unknown", described as "Booster"; ORTHOSTATIC HYPERTENSION (hospitalization, disability, life threatening) with onset 21Sep2021, outcome "not recovered", described as "Malignant orthostatic HYPERtension with physical manifestation"; LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (hospitalization, disability, life threatening) with onset 21Sep2021, outcome "not recovered", described as "unable to work, unable to perform routine daily activities"; COAGULATION TIME PROLONGED (hospitalization, disability, life threatening) with onset 21Sep2021, outcome "not recovered", described as "increased clotting time". The patient was hospitalized for immunisation, orthostatic hypertension, loss of personal independence in daily activities, coagulation time prolonged (hospitalization duration: 1 day(s)). The events "booster", "malignant orthostatic hypertension with physical manifestation", "unable to work, unable to perform routine daily activities" and "increased clotting time" were evaluated at the physician office visit and emergency room visit. The patient underwent the following laboratory tests and procedures: sars-cov-2 test: (unspecified date) negative; coagulation time: (21Sep2021) increased. Therapeutic measures were taken as a result of immunisation, orthostatic hypertension, loss of personal independence in daily activities, coagulation time prolonged included blood pressure medication and steroids.; Sender's Comments: As there is limited information in the case provided, the causal association between the events immunisation, orthostatic hypertension, loss of personal independence in daily activities and coagulation time prolonged with the suspect drug BNT162B2 cannot be excluded. The case will be reassessed once new information is available.