Age: 50.0
Sex: F
Vaccine: VARZOS
Symptoms: Injection site erythema, Injection site pain, Injection site swelling, Malaise, Neck pain
Clinical narrative: left eye turned red; felt pressure in eye; headache; felt cruddy; left nostril deep under eye pain' as Nasal pain; diagnosed with  pinguecula.; severe pain in neck -left side; weird body aches particularly feet; I felt cruddy" My left ear is "bothering me; left orbital pain, deep under left nostril, under eye,; could have been cellulitis; Pain at injection site; redness at injection site; swelling at injection site; Fever; mild-flu-like symptoms; This case was reported by a consumer via call center representative and described the occurrence of cellulitis in a 50-year-old female patient who received Herpes zoster (Shingrix) for prophylaxis.   Co-suspect products included dexamethasone eye drop for pinguecula and macrogol + propylene glycol (Systane) for pinguecula.   On 27th July 2022, the patient received the 1st dose of Shingrix. On an unknown date, the patient started dexamethasone eye drop .1 % 3 times daily (.3 % daily) and Systane at an unknown dose and frequency. On 29th July 2022, 2 days after receiving Shingrix, the patient experienced cellulitis (serious criteria GSK medically significant), injection site pain, injection site erythema, injection site swelling, fever and influenza-like symptoms. On 30th July 2022, the patient experienced pinguecula, neck pain, general body pain, ear discomfort, orbital pain, feeling unwell and nasal pain. On an unknown date, the patient experienced eye red, sensation of pressure in eye and headache. Dexamethasone eye drop was discontinued. Systane was discontinued. On an unknown date, the outcome of the cellulitis, injection site pain, injection site erythema, injection site swelling, pinguecula, fever, influenza-like symptoms, general body pain, ear discomfort, eye red, feeling unwell and nasal pain were unknown and the outcome of the neck pain, orbital pain, sensation of pressure in eye and headache were not recovered/not resolved.   It was unknown if the reporter considered the cellulitis, injection site pain, injection site erythema, injection site swelling, pinguecula, fever, influenza-like symptoms, neck pain, general body pain, ear discomfort, orbital pain, eye red, sensation of pressure in eye, headache, feeling unwell and nasal pain to be related to Shingrix.     Additional Information: GSK Receipt Date: 12-AUG-2022  Reporter's Comments: The patient reported that she received dose of Shingrix in left arm.  The patient stated by Friday morning 2 days later had to go to urgent care. She experienced pain redness and swelling at injection site (left arm).  The healthcare professional (HCP) believed could had been cellulitis and ordered antibiotics, but she waited and did not took them.  On 30th July 2022, 3 days after receiving Shingrix, the patient experienced severe pain in neck -left side, weird body aches particularly her feet, and felt cruddy, the patient left ear was bothering her and left orbital pain, deep under left nostril, under eye.  A few days later, less than 3 weeks after receiving Shingrix, her left eye turned red. When she could lie down to sleep, she felt pressure in her eye.  The patient went to eye doctor and 3 days after receiving Shingrix, was diagnosed with pinguecula.  The doctor prescribed eye drops dexamethasone 0.1 percent 3 times/day for 1 week and an over the counter wetting eye drop Systane.  The patient stated that the HCP discontinued both drops because her symptoms were worse with the drops. The eye drops reignited everything.  All the symptoms mentioned above come and go since receiving vaccine. Less than 2 weeks after receiving dexamethasone eye drop and Systane the patient experienced cellulitis, injection site pain, injection site erythema, injection site swelling, pinguecula, fever, influenza-like symptoms, neck pain, general body pain, ear discomfort, orbital pain, eye red, sensation of pressure in eye, headache, feeling unwell and nasal pain. It was unknown if the reporter considered the cellulitis, injection site pain, injection site erythema, injection site swelling, pinguecula, fever, influenza-like symptoms, neck pain, general body pain, ear discomfort, orbital pain, eye red, sensation of pressure in eye, headache, feeling unwell and nasal pain to be related to dexamethasone eye drop and Systane.