Age: 0.3
Sex: M
Vaccine: VARCEL
Symptoms: Autism, Neurodevelopmental disorder, Pyrexia, Rash
Clinical narrative: Information has been received from an RN concerning a 4 year old male who on 10/8/98 was vaccinated with Varicella virus vaccine live (628027/1257H). The pt had previous vaccinations including Hep-B, Hib conjugate vaccine, diphtheria toxoid (Infanrix-IPV-Hib) and measles-mumps-rubella. MMR was given on 12/18/98. In 1998, the pt developed a rash and fever of 101F after therapy with diphtheria toxoid/tetanus toxoid, Hep-B recombinant (yeast) and diphtheria toxoid (+) haemophilus b conjugate vaccine (+) pertussis vaccine (+) poliovirus vaccine (+) tetanus toxoid vaccination (WAES 01112562). Also in 1998, the pt developed a rash after being inoculated with diphtheria toxoid (+) haemophilus b conjugate vaccine (+) pertussis vaccine (+) poliovirus vaccine (+) tetanus toxoid vaccinations and Hep-B vaccine recombinant (yeast), which lasted 12 days (WAES 01112561). The RN reported that both fever and rash were thought to be related to a probable reaction to therapy with diphtheria toxoid (+) tetanus toxoid. In 6/99, the pt developed autism with a pervasive developmental disorder. The pt is being followed by a physician at the time of this report. Upon internal review, autism was considered an "Other Medical Event". Additional information has been requested. A 15-day follow up report received 2/5/2003 adds: Information has been received from a registered nurse concerning a 4 month old male with a 'casien' allergy, eggs allergy and gluten allergy and a history of transient synovitis in March 2001, and hospitalizatin for pneumonia in April 2001. On 10/08/1998 the pt was vaccinated with varicella virus vaccine live (lot #628027/1257H). Concomitant therapy included cotirixine hydrochloride (Zyrtec) prn. It was also reported that on 10/08/1997 the pt was vaccinated with Hepatitis B vaccine recombinant (yease) (MSD) (lot #624497/0923E) and on 11/07/1997 with HIB conjugate vaccine (MSD)(lot #624924/lll2E), alum. potassium (+) diphtheria toxoid (+) pertussis vaccine (+) tetanus toxoid (Tripedia), and poliovirus vaccine inactivated (IPOL). Subsequent to the vaccinations on 01/13/1998 the mother reported that the pt developed a rash and fever (101 F) (WAES #01112562). On 03/13/1998 the pt received a second dose of therapy with alum. potassium (+) diphtheria toxoid (-) pertussis vaccine (+) tetanus toxoid (Tripedia) and Hepatitis B vaccnie recombinant (yeast) (MSD) (lot #625399/1447E). Subsequent to the vaccinations on 03/13/1998 the pt developed a rash, 12 days duration (WAES #01112561). The registered nurse reported that both fever and rash were thought to be related to a probable reaction to therapy with alum. postassium (+) diphtheria toxoid (-) pertussis vaccine (+) tetanus toxoid. It was also reported that on 12/18/1998 the pt was vaccinated with measles virus vaccine live (-) mumps virus vaccine live (-) rubella virus vaccine live (second generation) (MSD) (lot #628905/1362H). In June 1999, the pt was diagnosed with pervasive developmental distorder, autism. The pt was being followed by a physician at the time of this report. Upon internal review autism was considered an other medical event. This is an amended report. The lot numbers have been corrected in the narrative. The pt's age now reads '4 month old' instead of '4 year old'. The concomitant therapy "diphtheria toxoid (+) Haemophilus B conjugate vaccine (+) pertussis vaccine (+) poliovirus vaccine (+) tetanus toxoid Infanrix-IPV-HIB' has been changed to 'alum. potassium (+) diphtheria toxoid (+) pertussis vaccine (+) tetanus toxoid (Tripedia) and poliovirus vaccine inactivated (IPOL).' The coding of 'drug reaction' has been removed as an adverse event. the pt's recovery status was changed to 'not recovered' to reflect the diagnosis of autism. Additional information has been requested. This report is corrected as amended.