Age: 68.0
Sex: F
Vaccine: VARZOS
Symptoms: Nausea, Ophthalmic herpes simplex, Pain, Pyrexia, Visual impairment
Clinical narrative: vision loss; herpes simplex in eye; vision problems; eye ulceration; eye pain; eye irritation; vomited; achy; fever; chills; nauseated; This case was reported by a consumer via call center representative and described the occurrence of loss of vision in a 68-year-old female patient who received Herpes zoster (Shingrix) for prophylaxis.   Previously administered products included Shingrix with an associated reaction of influenza like illness (received 1st dose 3 months begore receiving the 2nd dose of Shingrix and experienced flu like symptoms, refer case US2019AMR142096).   On 12th July 2019, the patient received the 2nd dose of Shingrix. On 12th July 2019, less than a day after receiving Shingrix and an unknown time after starting acyclovir, the patient experienced pain. On 13th July 2019, the patient experienced vomiting, fever, chills and nausea. On 16th July 2019, the patient experienced loss of vision (serious criteria GSK medically significant), ophthalmic herpes simplex (serious criteria GSK medically significant), abnormal vision, eye ulcer, eye pain and eye irritation. The patient was treated with acyclovir and antivirals nos. On an unknown date, the outcome of the loss of vision, ophthalmic herpes simplex, abnormal vision, eye ulcer and eye pain were recovering/resolving and the outcome of the eye irritation was not recovered/not resolved and the outcome of the vomiting, pain, fever, chills and nausea were recovered/resolved.   The reporter considered the loss of vision, ophthalmic herpes simplex, abnormal vision, eye ulcer, eye pain and eye irritation to be related to Shingrix. It was unknown if the reporter considered the vomiting, pain, fever, chills and nausea to be related to Shingrix.  Additional details were provided as follows: After receiving the 2nd dose of Shingrix,in the night the patient felt achy. On the next day after receiving Shingrix, at about 5 in the morning the patient experienced fever,chills and felt nauseated. The patient had 101 degree F temperature.  The patient vomited and felt like aching all over that lasted for about two days. On 16th July 2019, the patient started experiencing vision problems. On 18th July 2019 and 22nd July 2019, she called her physician and was diagnosed her with herpes simplex in her left eye.  The physician said that the Shingrix vaccine caused the herpes simplex.  The patient's eye was painful, irritating and she lost vision on that eye.  The day before the date of reporting, the patient could not see how to put on her lipstick. Her ophthalmologist had been having her coming back every other day since two weeks. The patient also experienced some ulceration in her eye.  The patient was treated with Antivirus drops first and it had not helped her so on her fourth day of oral treatment she was treated with Acyclovir. The reporter consented to follow up. It was reported that the company could follow up with her if they really need to speak to her primary care physician as she had not shared any of the information with the physician till the time of reporting.