Age: 0.2
Sex: F
Vaccine: DTAP, HBHEPB, IPV, DTAP, HBHEPB, IPV, DTAP, HBHEPB, IPV
Symptoms: Hypotension, Hypoxia, Injection site induration, Injection site mass, Irritability
Clinical narrative: The father of a 2 month old female reported that his daughter received her 1st dose of Acel-Imune, Comvax and IPV on 5/15/00. She reportedly developed a hard knot at the Acel-Imune injection site and became fussy. The induration resolved within several weeks and her fussiness abated within several days. On 5/22/00, she experienced a seizure. Her eyes turned up and to the right; she had slight neck stiffness and she would not respond when touched or her name was called. This episode resolved within 30 seconds. She had 3 similar episodes the next day and was hospitalized. She was treated with IV phenobarbital and discharged 2 days later with a prescription for po phenobarbital. She was seizure-free for "a couple of days" and then had 10 to 12 seizures a day. She was again hospitalized and treated with IV phenobarbital and was discharged 2 to 3 days later on Klonopin. Once the Klonopin was initiated, she began seizing again. On 6/12/00, she experienced status epilepticus (her seizures were more severe and lasted longer) and was taken to the ER on 6/13/00. Her oxygen was "down in the 40's". She was transferred to the ICU and treated with a "Versed drip" and was seizure-free for 2 or 3 days. Once oral seizure medication was re-started, the pt again began to seize. The pt was discharged on 7/18/00. According to the pt's father, various seizure medications have been prescribed; however, medication is now used only "for acute situations". The pt is currently on a ketogenic diet, as of 4/9/01, and continues to have 10 to 100 seizures per day. She has been on numerous seizure medications. She has been intubated. She now has noted developmental regression. She had decreased blood pressures on her Pentobarb coma drip and is taking ACTH to watch for high blood pressures. She spike a fever of 39.5C on 7/5/00. She was ampicillin and Claforan for 8 days in July. She has 1 episode of pneumonia. She has had physical and occupational therapy. She has constipation with abdominal pain treated with Milk of Magnesia. She has questionable GERD. Follow up info received on 05/23/2001 indicated that these events were life threatening and resulted in permanent disability. Follow-up info has been received from a physician who reports the child was dx'd with a Neurodegenerative Disease and is not expected to recover. The physician also reported that the child was a normal healthy child prior to the vaccinations. He stated that the cause of the disease has been thought to be either vaccine related or developmentally or genetically linked. Upon internal review, Neurodegenerative Disease was considered to be an "Other Important Medical Event". Additional info is not expected.F/U This is an amended report. Infusion site induration was changed to injection site induration. F/U info received from the physician on 9/25/01, indicated that the pt's status was essentially the same, still having 10-100 seizures per day. She has been dx'd with "uncontollable seizure disorder" and "neurogenerative disease". She has global development delays and "has been on multiple medical regimens from specialists around the country, none that have seemed to help".