Sex: F
Vaccine: VARZOS
Symptoms: Herpes zoster, Nerve injury, Pain, Vaccination failure
Clinical narrative: that it is possible to have shingles without having a rash/Suspected vaccination failure; contracted shingles without the rash/Zoster Sine Herpete; extreme pain//stabbing pain/localized pain; Nerve damage; localized pain below right shoulder/stabbing pain; This serious case was reported by a consumer and described the occurrence of vaccination failure in a female patient who received Herpes zoster (Shingrix) for prophylaxis.   Concurrent medical conditions included hepatic damage.   On an unknown date, the patient received Shingrix. On an unknown date, an unknown time after receiving Shingrix, the patient experienced vaccination failure (Verbatim: that it is possible to have shingles without having a rash/Suspected vaccination failure) (serious criteria GSK medically significant), shingles (Verbatim: contracted shingles without the rash/Zoster Sine Herpete), pain (Verbatim: extreme pain//stabbing pain/localized pain), nerve damage (Verbatim: Nerve damage) and shoulder pain (Verbatim: localized pain below right shoulder/stabbing pain). The patient was treated with hydrocodone, tramadol and fentanyl. The outcome of the vaccination failure was not reported and the outcome of the shingles, pain, nerve damage and shoulder pain were not resolved.   It was unknown if the reporter considered the vaccination failure, shingles, pain, nerve damage and shoulder pain to be related to Shingrix.     The company considered the vaccination failure to be unrelated to Shingrix. It was unknown if the company considered the shingles, pain, nerve damage and shoulder pain to be related to Shingrix.   Additional Information: GSK Receipt Date: 05-SEP-2024 The patient's husband reported that it was possible to had shingles without having a rash as it happened to patient. The patient suffered from extreme pain and found it difficult to make a appointment with a physician to prevent long lasting nerve damaged and shorten the duration of the pain. The patient started having localized pain below the right shoulder blade on Thursday night and still on Friday. The patient suffered increasing stabbing pain on Saturday and Sunday. The patient had agreed to go the emergency room on Monday morning at 4 AM. The pharmacist stated that they had been seeing many fall injury prescription and asked if we well. The reporter reported that it seems that antivirals might prevent long lasting nerve damage and shorten duration, but need to be given as soon as possible, like within 3 to 5 days. The reporter reported that he was on the 5 day bubble.  The reporter envision day after reporting appointment goin like this. The reporter asked that why they were there, it was too late for antivirals and a NPH could not prescribed pain medicine, could not take NSAID's due to liver damage and Tramadol was not phasing the pain. The Fentanyl in the hospital was great, but wore off by 8 AM. The reporter reported as zoster sine herpete. This case was considered as suspected vaccination failure as details regarding completion of primary schedule, time to onset and laboratory confirmation regarding shingles were unknown at the time of reporting.; Sender's Comments: Vaccination failure is a listed event which, due to the following criteria (insufficient information provided about the clinical description, details regarding completion of primary vaccination schedule, time to onset and laboratory confirmation of disease) is considered unrelated to GSK vaccine Shingrix.