Age: 38.0
Sex: F
Vaccine: COVID19
Symptoms: Condition aggravated, Fatigue, Feeling abnormal, Headache, Influenza like illness
Clinical narrative: Grave's disease symptoms were aggravated; Felt achy; Grave's disease symptoms were aggravated; Didn't feel great; Hair was falling out; Increase in anxiety; Fatigue; Joint pain; Headache; Worse than flu shot pain in her arm; Nausea; Body aches/felt achy; Chills; Headache; Could not lift her arm; Felt fluey but not severe; Nauseous; This spontaneous case was reported by a consumer and describes the occurrence of BASEDOW'S DISEASE (Grave's disease symptoms were aggravated) in a 38-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     The patient's past medical history included Kikuchi disease in 2008. Concurrent medical conditions included Graves' disease, Asthma, Anxiety, Seasonal allergy and Rash all over (body rashes). Concomitant products included LISDEXAMFETAMINE MESILATE (VYVANSE), CLONAZEPAM (KLONOPIN), ALBUTEROL [SALBUTAMOL], FLUTICASONE PROPIONATE (FLOVENT) and BUDESONIDE, FORMOTEROL FUMARATE (SYMBICORT) for Asthma, OXYMETAZOLINE HYDROCHLORIDE (CLARITIN ALLERGIC) and FLUTICASONE PROPIONATE (FLONASE [FLUTICASONE PROPIONATE]) for Seasonal allergy, THIAMAZOLE (METHIMAZOLE) and EPINEPHRINE (EPIPEN) for an unknown indication.   On 21-Mar-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 23-Apr-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 23-Apr-2021, the patient experienced NAUSEA (Nauseous). On 24-Apr-2021, the patient experienced MOVEMENT DISORDER (Could not lift her arm), INFLUENZA LIKE ILLNESS (Felt fluey but not severe), CHILLS (Chills), the first episode of HEADACHE (Headache), MYALGIA (Body aches/felt achy), NAUSEA (Nausea) and VACCINATION SITE PAIN (Worse than flu shot pain in her arm). In May 2021, the patient experienced CONDITION AGGRAVATED (Grave's disease symptoms were aggravated), FEELING ABNORMAL (Didn't feel great), ALOPECIA (Hair was falling out), ANXIETY (Increase in anxiety), FATIGUE (Fatigue), ARTHRALGIA (Joint pain) and the second episode of HEADACHE (Headache). On an unknown date, the patient experienced BASEDOW'S DISEASE (Grave's disease symptoms were aggravated) (seriousness criterion medically significant) and PAIN (Felt achy). On 23-Apr-2021, NAUSEA (Nauseous) had resolved. At the time of the report, BASEDOW'S DISEASE (Grave's disease symptoms were aggravated), CONDITION AGGRAVATED (Grave's disease symptoms were aggravated), MOVEMENT DISORDER (Could not lift her arm), INFLUENZA LIKE ILLNESS (Felt fluey but not severe), FEELING ABNORMAL (Didn't feel great), ALOPECIA (Hair was falling out), ANXIETY (Increase in anxiety), CHILLS (Chills), MYALGIA (Body aches/felt achy), FATIGUE (Fatigue), ARTHRALGIA (Joint pain), NAUSEA (Nausea) and VACCINATION SITE PAIN (Worse than flu shot pain in her arm) was resolving and PAIN (Felt achy) and the last episode of HEADACHE (Headache) outcome was unknown.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): In August 2021, Red blood cell count: little low (Low) little low. In August 2021, Thyroid function test: normal (normal) normal. In August 2021, White blood cell count: little low (Low) little low.         The patient used steroid cream and another cream that she could not remember the name of was also considered as concomitant medications.  Treatment medication was unknown.   The patient got her first Moderna dose in her right arm on 21/Mar/2021. She did not have her card with her to give lot numbers. She got her second dose in her left arm on 23/Apr/2021. She was nauseous right away but that disappeared quickly. About 12 hours after she had worse than flu shot pain in her arm, could not lift her arm, body aches, chills, headache, nausea, felt fluey but not severe. By the next day she was feeling better except for the headache which lasted until the following day. She felt like after she got the second dose everything was set off (Grave's disease symptoms were aggravated). She felt achy and didn't feel great. Her hair was falling out, and she had fatigue, joint pain, increase in anxiety, and headaches. She thinks it started in May. She had bloodwork and the thyroid hormones were in line, so her primary care did not adjust her medication. In the last 2-3 weeks everything seems to be leveling out. In August bloodwork indicated her thyroid was OK but red and white blood cell count was a little low. They were monitoring. Her primary care did all the bloodwork but was leaving the practice shortly.; Sender's Comments: This case concerns a 38-year-old, female patient with relevant medical history of Graves' disease and Asthma, who experienced the unexpected event of Grave's disease symptoms aggravated. The event occurred on the same day after the second dose of Spikevax. The rechallenge was not applicable. The benefit-risk relationship of Spikevax is not affected by this report. The patient had bloodwork done and the thyroid hormones were in line and no adjustment to her medication was suggested by primary physician.