Sex: F
Vaccine: COVID19
Symptoms: Arthralgia, Carpal tunnel syndrome, Hot flush, Thyroiditis, Vulvovaginal dryness
Clinical narrative: Hot flush; vaginal dryness; Arthralgia; Under active thyroiditis; carpal tunnel and due to carpal tunnel had surgery on 10-Jul-2023; This spontaneous case was reported by a patient and describes the occurrence of CARPAL TUNNEL SYNDROME (carpal tunnel and due to carpal tunnel had surgery on 10-Jul-2023) in a female patient of an unknown age who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 prophylaxis. The occurrence of additional non-serious events is detailed below.     The patient's past medical history included Dyspnea (Test perform and has no issue) on 11-Feb-2021, Tennis elbow (2 or 3 year over past 2 year) and Partial hysterectomy (no symptoms) in 2014. Previously administered products included for Product used for unknown indication: pfizer vaccine (Batch number EN6204, Given in arm by intramuscular) on 26-Mar-2021, pfizer vaccine (Batch number EW950 and Given in arm by intramuscular) on 17-Apr-2021; for COVID-19 prophylaxis: Moderna  Vaccine (Batch number 939902, Given in arm by intramuscular) on 15-Nov-2021, Moderna  Vaccine (Batch number 048L21A and Given in arm by intramuscular) on 29-Apr-2022. Past adverse reactions to the above products included No adverse event with Moderna  Vaccine, Moderna  Vaccine, pfizer vaccine and pfizer vaccine. Family history included Stroke (Father died in stroke) and Hyperlipidemia (Patient grandfather had high cholesterol). Concurrent medical conditions included Acne, Hyperlipidemia since 2006, Eye allergy, Homocysteinemia (high cysteine levels) since 2006, Seasonal allergy since 1998, Endometriosis since 1997, Nasal allergy, Gilbert's syndrome since 2010, Transaminitis (high liver enzymes) since 11-Feb-2021, Breast pain, Irritable bowel syndrome (every few years) since 2006, Hepatic cyst (Liver cyst  with no issue), Diverticulitis (mild diverticulitis detected by colonoscopy) since 01-Aug-2019 and Left inguinal hernia (surgery carried out on 15-Dec-2021) since October 2023. Concomitant products included ADAPALENE (DIFFERIN) and CLINDAMYCIN PHOSPHATE for Acne, CETIRIZINE HYDROCHLORIDE (ALLERTEC [CETIRIZINE HYDROCHLORIDE]) for Allergy, VENLAFAXINE HCL for Anxiety, EVENING PRIMROSE OIL [OENOTHERA BIENNIS OIL] for Breast pain, KETOTIFEN FUMARATE (ALAWAY) for Eye allergy, FOLIC ACID for Homocysteinemia, HERBAL POLLEN NOS (RELIZEN) for Hot flashes, ROSUVASTATIN CALCIUM (CRESTOR) from 31-Jan-2023 to an unknown date and EZETIMIBE from 17-Apr-2023 to an unknown date for Hypercholesterolemia, LEVOTHYROXINE from 06-Feb-2023 to an unknown date for Hypothyroidism, LIGAPLEX I and COQ10 [ASCORBIC ACID;BETACAROTENE;CUPRIC OXIDE;MANGANESE SULFATE;SELENIUM;TOCOPHERYL ACETATE;UBIDECARENONE;ZINC OXIDE] for Joint pain, TRIAMCINOLONE ACETONIDE (NASACORT) for Nasal allergy, HYALURONATE SODIUM (REVAREE) for Vaginal dryness, MINERALS NOS, VITAMINS NOS (PRENATAL VITAMINS [MINERALS NOS;VITAMINS NOS]), FISH OIL, CHONDROITIN SULFATE SODIUM, GLUCOSAMINE (GLUCOSAMINE AND CHONDROITIN) from 03-Mar-2023 to an unknown date, ZINC, CALCIUM CARBONATE, ERGOCALCIFEROL (CALCIUM AND VITAMIN D) and VITAMIN B NOS for an unknown indication.    On 09-Jul-2022, the patient received fifth dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular use) 1 dosage form. On 06-Feb-2023,  after starting mRNA-1273 (Moderna COVID-19 Vaccine), the patient experienced THYROIDITIS (Under active thyroiditis). In 2023, the patient experienced CARPAL TUNNEL SYNDROME (carpal tunnel and due to carpal tunnel had surgery on 10-Jul-2023) (seriousness criterion medically significant). On an unknown date, the patient experienced HOT FLUSH (Hot flush), VULVOVAGINAL DRYNESS (vaginal dryness) and ARTHRALGIA (Arthralgia). The patient was treated with Surgery (surgery on right hand) for Carpal tunnel syndrome. At the time of the report, CARPAL TUNNEL SYNDROME (carpal tunnel and due to carpal tunnel had surgery on 10-Jul-2023), THYROIDITIS (Under active thyroiditis), HOT FLUSH (Hot flush), VULVOVAGINAL DRYNESS (vaginal dryness) and ARTHRALGIA (Arthralgia) outcome was unknown.            No treatment medications provided by the reporter.  Company comment:  This is a spontaneous case concerning a female patient of unkonwn age, previously vaccinated with first two doses of Comirnaty vaccine, followed by 3 doses of Moderna vaccine, with relevant current condition of Homocysteinemia (high cysteine levels), Seasonal allergy, Endometriosis,  Nasal allergy, Gilbert's syndrome, Irritable bowel syndrome and Diverticulitis, who experienced the unexpected serious (medically significant) event of Carpal tunnel syndrome among other non serious events. The event occurred within 14 months after the administration of mRNA-1273 vaccine, used as a fifth dose.  The patient required surgery on her right hand. The benefit-risk relationship of mRNA-1273 Vaccine is not affected by this report.