Age: 55.0
Sex: F
Vaccine: VARZOS
Symptoms: Ear infection, Fear, Gait inability, Headache, Hypersensitivity
Clinical narrative: double vision; and in the hospital with Transverse Myelitis; paralyzed/paralyzed waist down; loss sensation in bowel/oss sensation in her bladder and bowel/could not feel her feet/getting worse; could not lift her legs up or walk/ could not walk; could not lift her legs up or walk; super sensitivity from her elbows to her upper body/unable to take warm showers/hypersensitivity sensations; too scared; felt ill/got worse; numbness and tingling in her feet.; tingling in her feet.; feet are always cold; weakness in legs; MOG positive; ear infection/getting worse; when they took her blood pressure it was very painful; loss sensation in bladder; headache/got worse; neck pain/got worse; pressure in her ears/got worse; This case was reported by a consumer via interactive digital media and described the occurrence of myelitis transverse in a 55-year-old female patient who received Herpes zoster (Shingrix) for prophylaxis.   The patient's past medical history included urinary catheter insertion (placed an indwelling urinary catheter).   On 10th June 2019, the patient received the 1st dose of Shingrix. In June 2019, less than 2 weeks after receiving Shingrix, the patient experienced myelitis transverse (serious criteria hospitalization and GSK medically significant), paralysis (serious criteria hospitalization and GSK medically significant), loss of sensation (serious criteria hospitalization), unable to walk (serious criteria hospitalization), mobility decreased (serious criteria hospitalization), hypersensitivity (serious criteria hospitalization), double vision (serious criteria hospitalization), headache, neck pain, sensation of pressure in ear, loss of bladder sensation and pain. On 18th June 2019, the patient experienced ear infection. On an unknown date, the patient experienced fear, feeling unwell, numbness in feet, tingling of extremity, cold feet, lower extremities weakness of and anti-myelin-associated glycoprotein antibodies positive. The patient was treated with antibiotics nos (Antibiotic (Details Unknown)), steroids nos (Steroid (Not Specified)) and rituximab (Rituxan Infusion). On an unknown date, the outcome of the myelitis transverse, paralysis, loss of sensation, mobility decreased, double vision, fear, headache, neck pain, sensation of pressure in ear, feeling unwell, loss of bladder sensation, ear infection, pain and anti-myelin-associated glycoprotein antibodies positive were unknown and the outcome of the unable to walk was recovered/resolved and the outcome of the hypersensitivity, numbness in feet, tingling of extremity, cold feet and lower extremities weakness of were not recovered/not resolved.   It was unknown if the reporter considered the myelitis transverse, paralysis, loss of sensation, unable to walk, mobility decreased, hypersensitivity, double vision, fear, headache, neck pain, sensation of pressure in ear, feeling unwell, loss of bladder sensation, ear infection, pain, numbness in feet, tingling of extremity, cold feet, lower extremities weakness of and anti-myelin-associated glycoprotein antibodies positive to be related to Shingrix.  Additional details were reported as follows: The patient felt ill after receiving the 1st dose of vaccine, she experienced headache, neck pain and pressure in her ears. She slowly got worse and loss sensation in her bladder and bowel. On 18th June 2019, she went to urgent care and was told she had an ear infection and was given an antibiotic shot along with an antibiotic prescription. She continued getting worse, she could not lift her legs up or walk so her husband took her to the emergency room on 22nd June 2019, and they placed an indwelling urinary catheter and she was sent to home. On 23rd June 2019, patient went to her doctor who admitted her into the hospital. By then she was paralyzed waist down and could not feel her feet and was experienced super sensitivity from her elbows to her upper body, she stated that when they took her blood pressure it was very painful. The patient started to slowly recover after she received steroid treatment in the hospital. She also experienced double vision after starting steroid treatment. After 12 days of hospitalization and rehab she was discharged. The patient was able to walk but had numbness and tingling in her feet. She had computer tomography scan, which was negative, her first MRI was positive for Transverse Myelitis. After treatment her MRI came back negative for inflammation or lesions of the spinal cord. Currently she was being treated and was receiving Rituxan infusion every six months. The infusion is scheduled for 8 hours first day and 15 days later for 4 hours. She had been tested for multiple scelerosis and Lyme's Disease which were negative, but myelin oligodendrocyte glycoprotein came back positive, she was told that it might be a false positive and was still being evaluated for possible myelin oligodendrocyte glycoprotein. Currently she was working on improving sensation of her bladder and bowel, and was still experiencing numbness and tingling in feet, her feet were always cold, and weakness in legs. At the time of reporting, patient was unable to take warm showers and had to take cool showers because she was still experiencing hypersensitivity sensations and tingling. The patient stated that she was ended up paralyzed and in the hospital with Transverse Myelitis aftr vaccination and was too scared. No other vaccines were received by her. The reporter consented to follow up.