Age: 1.51
Sex: M
Vaccine: HEP, IPV, PNC
Symptoms: Alanine aminotransferase increased, Aphasia, Aspartate aminotransferase normal, Autism, Autism spectrum disorder
Clinical narrative: Initial report received on 07/Jun/2006 from another manufacturer report number WAES0603USA00707. A two year old male pt had received a third dose injection of IPOL, lot number E1294; and a second dose injection of Prevnar, lot number 471214; on 06/Jul/2000. He had received a fourth dose injection of ACTHIB, lot number N1166AB; a fourth dose injection of Diphtheria, Tetanus and Acellular Pertussis vaccine, manufacturer not reported, lot number U00400B; and a first dose injection of Prevnar, lot 471207; on 01/May/2000. He had received a first dose injection of MMR vaccine, lot number 633012/1276J; and an injection of Varicella Virus Vaccine, lot 631474/1350J; on 13/Jan/2000. He had received a third dose injection of Hep B Virus Vaccine, lot number 629354/1739H, on 29/Oct/1999. On 01/Feb/2001, 30 weeks after receiving the 06/Jul2000 vaccinations, the pt experienced a febrile seizure while sleeping that lasted for four minutes. He was examined by a physician the following day. At that time, it was noted that the patient had poor speech and autism was questioned. On 15/Feb/2001, he had an audiology consult due to delayed speech and development. At that consult, the mother reported that her son was the product of a normal pregnancy, labor and delivery and that he was healthy at birth. The mother mentioned some concerns over poor eye contact. The audiology test results indicated no consistent and reliable responses below 30 dBHL. Based on this test, the possibility of a mild hearing loss could not be ruled out. On 28/Feb/2001 he was examined by a physician where poor eye contact and fixating on objects like a pen were noted. He was referred to a neurologist to rule out autism vs neurological impairment. During neurologist exam, on 05/Mar/01, hearing was felt to be normal. Principle concerns were poor eye contact, tending to stand in front of television wagging his hands and shimmering his body and not responding to voice. He had absolutely no words and did not demonstrate body parts or imitate animal sounds. He finger fed but did not use a spoon. Gross motor skills were normal. The neurologist noted that he did well as an infant without significant illness. He had mild gastroesophageal reflux and had three seizures with fever (Mar/2000, Sep/2000 and Feb 2001). The assessment was childhood autism and appeared mentally retarded. On 13/Mar/2001, he was again examined by an audiologist and found to have reliable and consistent responses to speech at 25 dBHL. On 14/Jun/2001, he had a speech language evaluation, and the impression was severe speech language impairment due to autism. On 08/Aug/2001, he had a pediatric development evaluation, and the impression was developmental delay, unspecified. On 15/Aug/2001, part two of the pediatric development evaluation was performed and showed impairments of social interaction, poor eye contact, decreased peer interaction, no joint attention and a delay in sharing of enjoyment. He was essentially nonverbal and had delays in nonverbal behaviors. He also had repetitive play, restricted interests, repetitive behaviors and self-stimulatory behavior. The diagnosis was autistic spectrum disorder/autism. On 17/Sep/2001, he was examined by the neurologist, and the assessment was childhood autism, moderate to severe in degree. There was no neurologic issues that would prompt any further diagnostic studies. On 26/Apr/2002, he was re-examined by the neurologist, and there were no new symptoms or diagnostic studies. On 26/Apr/2002, he was re-examined by the neurologist, and there were no new symptoms or diagnostic studies. On 26/Apr/2002, he was re-examined by the neurologist, and there were no new symptoms or concerns. A speech language evaluation, on 06/Jul/2005, indicated autism and associated atypical behaviors and apparent global developmental delays. There were severely to profoundly delayed atypical receptive and expressive language skills with estimated functional skills not yet consistent at the two year level. Much of his language was echolalia. On 25/Aug/2005, a psychological exam impression was autistic disorder and mental retardation. At the time of this report, the pt had not recovered. Additional reported illnesses included leg strain (26/May/2000), viral illness (02/Oct/2000), runny nose and cough (03/Nov/2000), a lump on the left side of his neck (28/Feb/2001), eczema (02/Mar/2001), gastroesophageal reflux disease (05/Mar/2001), an ear infection (10/Mar/2001), a verrucous papule (26/Jul/2001), snores (onset unknown), and constipation (onset unknown).