Age: 85.0
Sex: F
Vaccine: VARZOS
Symptoms: Balance disorder, Bladder catheterisation, Bladder dysfunction, Constipation, Decreased appetite
Clinical narrative: This case was reported by a consumer via call center representative and described the occurrence of myelitis transverse in a 85-year-old female patient who received SHINGRIX for prophylaxis. The patient's past medical history included trigeminal neuralgia. On 3rd July 2018, the patient received SHINGRIX (intramuscular) .5 mcg/mg. In July 2018, less than a month after receiving SHINGRIX, the patient experienced myelitis transverse (serious criteria hospitalization and GSK medically significant), unable to walk (serious criteria hospitalization), memory deficit (serious criteria hospitalization), urinary incontinence (serious criteria hospitalization), balance difficulty (serious criteria hospitalization), urinary frequency (serious criteria hospitalization), constipation (serious criteria hospitalization), mobility decreased (serious criteria hospitalization) and bladder dysfunction. On 16th July 2018, the patient experienced appetite lost (serious criteria hospitalization), general body pain (serious criteria hospitalization) and feeling unwell. On an unknown date, the outcome of the myelitis transverse, appetite lost, unable to walk and bladder dysfunction were recovering/resolving and the outcome of the memory deficit, urinary incontinence, balance difficulty and urinary frequency were not recovered/not resolved and the outcome of the general body pain and constipation were recovered/resolved and the outcome of the mobility decreased and feeling unwell were unknown. It was unknown if the reporter considered the myelitis transverse, appetite lost, unable to walk, memory deficit, urinary incontinence, balance difficulty, urinary frequency, general body pain, constipation, mobility decreased, feeling unwell and bladder dysfunction to be related to SHINGRIX. Additional information was reported as follows: The patient had a history of trigeminal neuralgia and it was related to her trigeminal neuralgia.  On 16th July 2018, the patient started feeling very unwell and experienced loss of appetite. The patient stated that something was wrong all over. On 16th July 2018, the patient went to the hospital, she was in great pain, the pain was all over. The patient could not move down from her waist, she was only able to move her toes. The patient was catharized in the hospital. The patient stated that she was not completely recovered. The patient had also lost control on her bladder function, which had left her with incontinency and urinary frequency. The patients' memory function was poor. The patient had to think longer for answers. The patient was diagnosed with transverse myelitis while she was hospitalised. The hospital performed tests and was admitted for a period of 2 and a half weeks as she could not walk and then was a taken to a rehab for a period of 2 and a half weeks again. The patient was suggested with treatment and she had blood removed and plasma exchanged 5 times with 1 day in between each treatment. At the time of reporting, the patient walks with a walker due to loss of balance.