chrisvoncsefalvay/vaers-narrative-generation huggingface dataset:
Age: 70.0
Sex: M
Vaccine: COVID19
Symptoms: Fatigue, Nausea, Vomiting
Clinical narrative: Nausea and vomiting for 15 hours and extreme fatigue
Age: 36.0
Sex: F
Vaccine: COVID19
Symptoms: Chills, Fatigue, Headache, Pain, Pyrexia
Clinical narrative: Fever,chills, body aches, headache, fatigue
Age: 60.0
Sex: F
Vaccine: COVID19
Symptoms: Abdominal pain upper, Migraine, Myalgia, Pyrexia
Clinical narrative: Migraine type headache, Muscle aches, Fever 102, severe stomach pain.
Age: 54.0
Sex: F
Vaccine: COVID19
Symptoms: Imaging procedure, Ophthalmological examination, Retinal vein occlusion, Visual impairment
Clinical narrative: Impaired right eye vision.   01/29/2021- Retina Specialist diagnosed: Hemiretinal Vein Occlusion Right Eye. Will begin treatment for ocular injections in the next week
Age: 72.0
Sex: F
Vaccine: COVID19
Symptoms: Arthralgia, Chills, Pain, Pyrexia
Clinical narrative: Fever chills muscle aches joint aches
Age: 43.0
Sex: M
Vaccine: COVID19
Symptoms: Chills, Dizziness, Fatigue, Pain, Pyrexia
Clinical narrative: Lightheaded, Body Aches, Chills, Fever, Fatigue
Age: 69.0
Sex: F
Vaccine: COVID19
Symptoms: Injection site erythema, Lymphadenopathy, Pruritus, Ultrasound breast
Clinical narrative: A red large oval occurred at site of injection a few hours later. Lasted for about 10 days. Occasional itching.  Main issue- I went for scheduled mammogram and  breast ultra sound (Jan 26) and 2 axillary  lymph nodes were enlarged. (same side as injection). Biopsy was suggested a week later. When I went a week later the nodes had gotten smaller almost normal so no biopsy was needed. It was attributed to the vaccine.
Age: 52.0
Sex: F
Vaccine: COVID19
Symptoms: Dizziness, Hypersensitivity
Clinical narrative: Lightheaded and Dizziness approximately 1 hour post vaccine.  Was seen in ED triage and was given meclizine 25mg oral x 1 for allergic reaction
Age: 51.0
Sex: F
Vaccine: COVID19
Symptoms: Injection site cellulitis, Pruritus, Pyrexia
Clinical narrative: Pt reached out to discuss concerns of of the second Moderna immunization.  Pt reported small localized cellulitis around injection site following first injection about a week following as well a high fever about 12 hours.   Pt premedicated at home with loratiadine and Tylenol.  Pt medicated with 12.5 mg Benadryl elixir prior to receiving second vaccination. 12:22 - pt reports feeling a little itchy - additional 12.5 mg Benadryl elixir provided. 12:35 - Pt reports feeling fine and is going to return to work for the afternoon.   Pt instructions given regarding return to the ED and signs and symptoms to watch for.  Pt verbalizes understanding states she will reach out for any additional concerns.
Age: 66.0
Sex: M
Vaccine: COVID19
Symptoms: Influenza like illness, Nausea, Pain, Sleep deficit, Vomiting
Clinical narrative: Client states that 24 hours post vaccination he began experiencing  nausea, vomitting, chills, lack of sleep, body aches. He states the felt like "he had the flu but it was on steroids and much more severe". He contacted his PCP and he instructed him to not take the second dose.
Age: 69.0
Sex: F
Vaccine: COVID19
Symptoms: Tinnitus
Clinical narrative: Mild tinnitus - remained under observation for 30 minutes.
Age: 62.0
Sex: F
Vaccine: COVID19
Symptoms: Injection site erythema
Clinical narrative: "COVID Vaccine Arm"  (or simply "COVID Arm")  On day 8 following  the vaccination, a bright/dark red "patch" or area suddenly appeared on my upper left arm which was the location of the COVID-19 vaccine injection.  The patch/area is slightly raised and about 2x2 inches or so.   It was a TINY bit sore to touch but not really painful yesterday.  It remains today (day 9) but is not even sore.
Age: 81.0
Sex: M
Vaccine: COVID19
Symptoms: Urticaria
Clinical narrative: Hives
Age: 57.0
Sex: M
Vaccine: COVID19
Symptoms: Injection site pain, Injection site warmth, Musculoskeletal stiffness
Clinical narrative: Upper left arm warm , stiff and really sore near injection site that continues for 20 days following Pfizer shot
Age: 88.0
Sex: F
Vaccine: COVID19
Symptoms: Injection site erythema, Injection site pruritus, Injection site rash, Injection site swelling
Clinical narrative: Swelling, itching, redness/rash at injection site - occurred 8 days after injection. Saw doctor on 2/2/21 due to concern. Antibiotics were prescribed.
Age: 71.0
Sex: M
Vaccine: COVID19
Symptoms: Dyspnoea, Eye irritation
Clinical narrative: On 2/3/21 a 71y/o Male arrived to the library to recieve a CoVID Vaccine from County Fire. Pt recieved Vaccine and during 30minute observation period pt began to have symptoms of SOB and Eye irritation. Pt was evaluated by FIre/EMS Staff.Pt c/c was SOB. Pt was evaluated by on site paramedic with no treatment. Pt was offered transport to local hospital but pt refused. Pt Signed AMA after hospital contact.  For Further record of pt viitals, information, and care reference EMS PCR HCFA2021-00007716 Incident #HCFA2021-00007716
Age: 50.0
Sex: F
Vaccine: COVID19
Symptoms: Diarrhoea, Erythema, Fatigue, Nausea, Peripheral swelling
Clinical narrative: Five hours after injection, intractable nausea, dry heaving, fatigue, then diarrhea. 3 to 4 days after vaccine, pruritus, erythema, swelling of fingers and hands, arms up to elbows, right shoulder, erythema and pruritus of buttocks, and then feet bilaterally. She was already on cetirizine but added fexofenadine and Benadryl without relief. Symptoms subsided after three days.
Age: 50.0
Sex: F
Vaccine: COVID19
Symptoms: Pruritus, Retching
Clinical narrative: Five hours after injection, intractable nausea, dry heaving, fatigue, then diarrhea. 3 to 4 days after vaccine, pruritus, erythema, swelling of fingers and hands, arms up to elbows, right shoulder, erythema and pruritus of buttocks, and then feet bilaterally. She was already on cetirizine but added fexofenadine and Benadryl without relief. Symptoms subsided after three days.
Age: 69.0
Sex: F
Vaccine: COVID19
Symptoms: Cough, Decreased appetite, Dyspnoea, Fatigue, Myalgia
Clinical narrative: Next day of vaccine I had fatigue, muscle pain, lost of appetite, & sore arm. On the 1/28/2021 I started coughing & continued with shortness of breath since dose 1 & I still have coughing its improving but its still there.
Age: 69.0
Sex: F
Vaccine: COVID19
Symptoms: Pain in extremity
Clinical narrative: Next day of vaccine I had fatigue, muscle pain, lost of appetite, & sore arm. On the 1/28/2021 I started coughing & continued with shortness of breath since dose 1 & I still have coughing its improving but its still there.
Age: 64.0
Sex: F
Vaccine: COVID19
Symptoms: Dizziness, Nausea, Pain, Pain in extremity, Pyrexia
Clinical narrative: "Moderna COVID-19 Vaccine EUA"            Had Moderna Vaccine #2.  on FEb 2,2021     Had no problem with Moderna Vaccine # 1 except a sore arm. Woke up last night at 1:00 am with fever, and when I got up in the morning , I was nauseous and felt like I was going to pass out.  Whole body was aching me and took Tylenol for fever, which started at 100 degrees and went up to 101 1/2 by the afternoon.    slept and rested and it is 5:10 pm now and I feel little bit better.
Age: 32.0
Sex: F
Vaccine: COVID19
Symptoms: Fatigue, Pyrexia
Clinical narrative: 11:00am the next day began experiencing significant fatigue, then by 1:30pm I had a 100 degree fever that climbed to 102 as the afternoon went on. I took Tylenol at 5:00pm and by 6:30 my fever was down to 100 degrees. By 11:00pm I was down to 99 with no increase in temperature after that.
Age: 23.0
Sex: M
Vaccine: COVID19
Symptoms: Generalised tonic-clonic seizure
Clinical narrative: Grand Mal seizure.  55 hours post vaccine.  Lasted 15 minutes and required emergency rescue medication Nayzilam. He has seizure disorder but his seizures are well controlled. Typically only has one post op brain surgery or due to illness/infection.  Has less than 10 in his life. Phoned one of his physicians to report the seizure and discuss situation.  Was told to just watch for other symptoms or side effects.  He recovered from seizure and rescue med.  Notified two other doctors of the event the next work day.
Age: 59.0
Sex: F
Vaccine: COVID19
Symptoms: Arthralgia, Arthritis, Fatigue, Headache, Oral pruritus
Clinical narrative: I had severe fatigue,  headache, all over body itching , light sensitivity and itching in my mouth. I also had joint pain with swelling and arthritis in my hands.
Age: 59.0
Sex: F
Vaccine: COVID19
Symptoms: Photophobia, Pruritus, Swelling
Clinical narrative: I had severe fatigue,  headache, all over body itching , light sensitivity and itching in my mouth. I also had joint pain with swelling and arthritis in my hands.
Age: 45.0
Sex: F
Vaccine: COVID19
Symptoms: Cellulitis, Fatigue, Myalgia
Clinical narrative: Cellulitis( red arm wrapping around entire bicep) , Muscle pain, fatigue
Age: 73.0
Sex: M
Vaccine: COVID19
Symptoms: Muscle spasms
Clinical narrative: Muscle spasms and leg cramps Treated with Oxycodone and Cyclobenzaprine
Age: 1.0
Sex: M
Vaccine: MMR
Symptoms: Expired product administered
Clinical narrative: Monday 2/1/21 administered MMR 2 vaccine SQ. Vaccine expired 1/14/21.
Age: 44.0
Sex: M
Vaccine: COVID19
Symptoms: Flushing, Throat tightness
Clinical narrative: At 15 minutes I felt flushed and a tightness in my throat. I was moved to private observation with nurse for an additional 30 minutes. After the additional 30 minutes, I started feeling better. I was released to go home.
Age: 45.0
Sex: F
Vaccine: COVID19
Symptoms: Fatigue, Headache, Pain, Pyrexia
Clinical narrative: Headache, fever (100.7), body aches, fatigue
Age: 27.0
Sex: F
Vaccine: COVID19
Symptoms: Blood test, Chest pain, Dyspnoea, Pulmonary embolism
Clinical narrative: Shortness of breath and severe Chest pain. Ended up being a pulmonary embolism. Placed on Eliquis.
Age: 56.0
Sex: M
Vaccine: COVID19
Symptoms: Chills, Fatigue, Nausea, Pyrexia, Syncope
Clinical narrative: Fever, beginning on day after shot, lasted 2 days. The second day after shot he fainted upon standing up and hit the wall, nausea, fever, fatigue, chills.
Age: 84.0
Sex: M
Vaccine: COVID19
Symptoms: Paraesthesia
Clinical narrative: Tingling in right hand
Age: 65.0
Sex: F
Vaccine: COVID19
Symptoms: Injection site pain, Injection site pruritus, Injection site rash, Injection site swelling, Injection site warmth
Clinical narrative: raised area over the injection site, warm and painful to the touch with a silver dollar size red rash just below the injection site. This reaction occurred about 7 hrs after the shot was given and lasted approximately 2 days after which all of the reactions disappeared. About 7 days later, a smaller rash reappeared with itching off and on during the day consistently up to this filing. The itch is not intolerable, it is just noticeable, no medication has been applied to relieve the itch. I have had no fever, chills, aches or any other more severe reaction, just this residual rash with occasional itch.
Age: 65.0
Sex: F
Vaccine: COVID19
Symptoms: Rash erythematous
Clinical narrative: raised area over the injection site, warm and painful to the touch with a silver dollar size red rash just below the injection site. This reaction occurred about 7 hrs after the shot was given and lasted approximately 2 days after which all of the reactions disappeared. About 7 days later, a smaller rash reappeared with itching off and on during the day consistently up to this filing. The itch is not intolerable, it is just noticeable, no medication has been applied to relieve the itch. I have had no fever, chills, aches or any other more severe reaction, just this residual rash with occasional itch.
Age: 68.0
Sex: F
Vaccine: COVID19
Symptoms: Fatigue, Nausea
Clinical narrative: extreme fatigue ; nausea
Age: 64.0
Sex: F
Vaccine: COVID19
Symptoms: Arthralgia, Body temperature increased, Chills, Injection site pain, Malaise
Clinical narrative: First vaccine administered- Second vaccine- fever, chills, pain at injection site, temperature 103. 4, malaise, joint pain
Age: 64.0
Sex: F
Vaccine: COVID19
Symptoms: Pyrexia
Clinical narrative: First vaccine administered- Second vaccine- fever, chills, pain at injection site, temperature 103. 4, malaise, joint pain
Age: 39.0
Sex: F
Vaccine: COVID19
Symptoms: Arthralgia, Back pain, Chills, Headache, Neck pain
Clinical narrative: Same Day Left arm, neck, and back severe pain  Next day Fever 101.1  Chills Full body aches Headache Joint pain
Age: 39.0
Sex: F
Vaccine: COVID19
Symptoms: Pain, Pain in extremity, Pyrexia
Clinical narrative: Same Day Left arm, neck, and back severe pain  Next day Fever 101.1  Chills Full body aches Headache Joint pain
Age: 67.0
Sex: F
Vaccine: COVID19
Symptoms: Asthenia, Headache, Lethargy, Muscle spasms, Pyrexia
Clinical narrative: Had fever day 2, checked it once 5 minutes after drinking cold soda and eating ice cream and it was 100.8, so it was probably higher, would reduce with Advil for awhile but return.  Had all symptoms associated with elevated temp, lethargy, headache, weakness. Also had Leg cramps. Lasted all day, finally broke at 4 am.  Lasted about 24 hours.  All symptoms gone after 24hours but I was tired from leg cramps and slept most of day 3.
Age: 37.0
Sex: F
Vaccine: COVID19
Symptoms: Body temperature increased, Chills, Ear pain, Headache, Injection site pain
Clinical narrative: Started with pain at the sight of injection within hours of receiving injection. Progressed to sore left side of neck, then headache and sinus pain with nausea. Woke up around 11pm feeling achy all over with chills. Temperature was 100.8F. Through the night and the next day, the fever fluctuated with the highest temp recorded being 102.7F. Other symptoms experienced overnight and continuing to present include headache, body aches, sinus pain, nausea, ear pain, slight sore throat, pain at the injection site.
Age: 37.0
Sex: F
Vaccine: COVID19
Symptoms: Nausea, Neck pain, Oropharyngeal pain, Pain, Sinus pain
Clinical narrative: Started with pain at the sight of injection within hours of receiving injection. Progressed to sore left side of neck, then headache and sinus pain with nausea. Woke up around 11pm feeling achy all over with chills. Temperature was 100.8F. Through the night and the next day, the fever fluctuated with the highest temp recorded being 102.7F. Other symptoms experienced overnight and continuing to present include headache, body aches, sinus pain, nausea, ear pain, slight sore throat, pain at the injection site.
Age: 34.0
Sex: F
Vaccine: COVID19
Symptoms: Chills, Nausea, Pain, Pyrexia, SARS-CoV-2 test negative
Clinical narrative: I just felt body ache, fever, chills and a little bit of nausea. This lasted about 3 days.  I had to get a Covid swab and doctor note for clearance.
Age: 75.0
Sex: F
Vaccine: COVID19
Symptoms: Erythema, Pain in extremity, Swelling
Clinical narrative: Left arm pain, erythema, swelling.
Age: 45.0
Sex: F
Vaccine: COVID19
Symptoms: Fatigue, Headache, Influenza like illness, Musculoskeletal stiffness, Nausea
Clinical narrative: fatigue extreme extreme headache  flu like symptoms fever 100 stiffness in neck nausea body aches
Age: 45.0
Sex: F
Vaccine: COVID19
Symptoms: Pain, Pyrexia
Clinical narrative: fatigue extreme extreme headache  flu like symptoms fever 100 stiffness in neck nausea body aches
Age: 18.0
Sex: M
Vaccine: COVID19
Symptoms: Eye swelling
Clinical narrative: pt presents w/ swelling bil eyes, no swelling noted to face, no other s/s, pt in no distress, eye swelling subsided w/in 30 mins. A&Ox4. mother with son, released home & encouraged to continue to monitor and report additional or adverse reactions to physician or to call 911 if difficulty breathing, pt will take benadryl po at home. mother states that this happened with 1st dose.
Age: 37.0
Sex: F
Vaccine: COVID19
Symptoms: Pruritus, Rash
Clinical narrative: 5 days after vaccination, developed a rash on face that eventually spread to neck. Rash feels painful like sunburn and is itchy.  Skin is dry and scaly
Age: 42.0
Sex: F
Vaccine: COVID19
Symptoms: Rash
Clinical narrative: Rash to left arm started about 10 minutes after injection
Age: 65.0
Sex: F
Vaccine: COVID19
Symptoms: Blood pressure increased, Dyspnoea, Throat irritation, Throat tightness
Clinical narrative: About 15 minutes after receiving Pfizer vaccine dose 1 IM LD, pt experienced itchiness and tightness of the throat and breathing difficulty. Pt immediately brought to nearby cots to lay down. BP 130/78, Pulse 92, O2 99. 5 minutes later BP increased to 142/86, Pulse 70, O2 99. Pt began to relax a bit but symptoms were unchanged and Epinephrine 0.3mg x1 given & EMS called. BP 10 minutes later 144/80, pulse 70 O2 99. EMS arrived 10 minutes later, BP 146/90, and brought to nearby hospital.
Age: 40.0
Sex: F
Vaccine: COVID19
Symptoms: Dyspnoea, Flushing
Clinical narrative: Patient felt flushed and experienced shortness of breath (history of anxiety, panic attacks). Drank water and felt better in 10 minutes.
Age: 49.0
Sex: F
Vaccine: COVID19
Symptoms: Chest discomfort, Dizziness
Clinical narrative: Chest tightness and lightheaded
Age: 57.0
Sex: F
Vaccine: FLU4, MMR, TDAP, VARCEL
Symptoms: Incorrect route of product administration, No adverse event
Clinical narrative: MMR vaccination was accidentally administered via IM route instead of needed SC route. Pt was informed of this immediately, all questions and concerns were answered. Pt sustained no injuries, was monitored for 15 minutes post-vaccination. Pt encouraged to call with questions or concerns.
Age: 30.0
Sex: F
Vaccine: COVID19
Symptoms: Asthenia, Cough, Fatigue, Head discomfort, Injection site erythema
Clinical narrative: Fatigue. Soreness at site. Swelling of bicep around puncture site. Redness and heat at injection site. Cough. Sore throat. Nasal drainage. Fever greater than 101. Weakness.   Pain and swelling began about 6-7 hours after injection.  Cough fatigue onset 12 hours after injection.  Nasal congestion and fever onset 24 hours after injection.   Treatment: otc tylenol, ibuprofen, trazadone to sleep. Increased fluid intake. Increased rest.   Outcome: 48 hours post injection- still febrile. Head congestion. Cough. Weakness and body aches. Swelling decreased at injection site.
Age: 30.0
Sex: F
Vaccine: COVID19
Symptoms: Injection site pain, Injection site swelling, Injection site warmth, Oropharyngeal pain, Pain
Clinical narrative: Fatigue. Soreness at site. Swelling of bicep around puncture site. Redness and heat at injection site. Cough. Sore throat. Nasal drainage. Fever greater than 101. Weakness.   Pain and swelling began about 6-7 hours after injection.  Cough fatigue onset 12 hours after injection.  Nasal congestion and fever onset 24 hours after injection.   Treatment: otc tylenol, ibuprofen, trazadone to sleep. Increased fluid intake. Increased rest.   Outcome: 48 hours post injection- still febrile. Head congestion. Cough. Weakness and body aches. Swelling decreased at injection site.
Age: 30.0
Sex: F
Vaccine: COVID19
Symptoms: Pyrexia, Rhinorrhoea
Clinical narrative: Fatigue. Soreness at site. Swelling of bicep around puncture site. Redness and heat at injection site. Cough. Sore throat. Nasal drainage. Fever greater than 101. Weakness.   Pain and swelling began about 6-7 hours after injection.  Cough fatigue onset 12 hours after injection.  Nasal congestion and fever onset 24 hours after injection.   Treatment: otc tylenol, ibuprofen, trazadone to sleep. Increased fluid intake. Increased rest.   Outcome: 48 hours post injection- still febrile. Head congestion. Cough. Weakness and body aches. Swelling decreased at injection site.
Age: 22.0
Sex: F
Vaccine: COVID19
Symptoms: Injection site erythema, Injection site pruritus
Clinical narrative: Itching around vaccine site a week after- red circle around vaccine site
Age: 82.0
Sex: F
Vaccine: COVID19
Symptoms: Dizziness, Headache, Syncope
Clinical narrative: Dizziness,  severe headache, fainting
Age: 48.0
Sex: M
Vaccine: COVID19
Symptoms: Angioedema, Circumoral oedema
Clinical narrative: Peri-oral Angioedema:   Mild but obvious angioedema of left lower lip started around 30 hours post-injection on 1/29/21, which subsided overnight and migrated to involve predominantly the right lower lip the following day (1/30/21), which similarly subsided spontaneously over a few hours, followed with very mild (noticeable to patient but less obvious to others) angioedema of the upper lip appearing on morning of 1/31/21, fully resolved by around noon that day and has not recurred.
Age: 56.0
Sex: F
Vaccine: COVID19, COVID19, COVID19
Symptoms: Chest discomfort, Dizziness, Dyspnoea
Clinical narrative: About 10 minutes after receiving the vaccine, Patient began experiencing chest tightness, shortness of breath, and dizziness. 911 was called.  50 mg of Benadryl was given at 11:00, then 1 EpiPen administered at 11:10 when her symptoms worsened. Pulse ox was taken and was 97%. EMT arrived and the patient was transported to a local hospital. The patient reported feeling better when contacted by a site administrator later that day.
Age: 56.0
Sex: F
Vaccine: COVID19, COVID19, COVID19
Symptoms: Anaphylactic reaction
Clinical narrative: About 10 minutes after receiving the vaccine, Patient began experiencing chest tightness, shortness of breath, and dizziness. 911 was called.  50 mg of Benadryl was given at 11:00, then 1 EpiPen administered at 11:10 when her symptoms worsened. Pulse ox was taken and was 97%. EMT arrived and the patient was transported to a local hospital. The patient reported feeling better when contacted by a site administrator later that day.
Age: 82.0
Sex: F
Vaccine: COVID19
Symptoms: Deafness unilateral, Dizziness, Fatigue, Headache, Pyrexia
Clinical narrative: The following symptoms began the day after the shot:  headache, dizziness, tiredness, fever, complete loss of hearing in right ear, partial loss of hearing in left ear,  Hearing loss lasted 6 hours before beginning to improve.  Most symptoms were gone by end of 4th day.  Tiredness remains along with occasional dizziness.
Age: 60.0
Sex: U
Vaccine: COVID19
Symptoms: Blood pressure fluctuation, Dizziness, Flushing, Nausea
Clinical narrative: Patient started to experience nausea, flushing, lightheadedness after receiving 2nd dose of Moderna COVID-19 vaccine.  Patient reports they did not experience these symptoms following the 1st dose of the vaccine four weeks prior.  At 8:20am:  161/77  O2 sat=99%  HR=86.  At 8:24am:  BP=160/79,  At 8:29:  nausea subsiding, continued lightheadedness.    At 8:32am, BP=164/88.  Patient clinically stable.  Feels better.  Patient released from clinic at 8:34am.
Age: 39.0
Sex: F
Vaccine: COVID19
Symptoms: Dysgeusia, Erythema, Flushing
Clinical narrative: Patient voiced having metallic taste in mouth and had mild redness on chest and stated chest felt warm.  Patient denied any itching.
Age: 49.0
Sex: F
Vaccine: COVID19
Symptoms: Dizziness, Erythema, Headache, Injection site pain, Nodule
Clinical narrative: 10 days after receiving first dose of Moderna vaccine, patient developed a right arm nodule with right arm tenderness and erythema as well as a headache and dizziness.  She reports that the dizziness, headaches, and nodule have resolved, but she continues to experience right arm erythema. Small amount of right arm erythema noted on exam.  Small amount of tenderness noted at the injection site.  No streaking erythema or discharge noted. Patient started on prednisone and hydroxyzine for 5 days
Age: 49.0
Sex: F
Vaccine: COVID19
Symptoms: Tenderness
Clinical narrative: 10 days after receiving first dose of Moderna vaccine, patient developed a right arm nodule with right arm tenderness and erythema as well as a headache and dizziness.  She reports that the dizziness, headaches, and nodule have resolved, but she continues to experience right arm erythema. Small amount of right arm erythema noted on exam.  Small amount of tenderness noted at the injection site.  No streaking erythema or discharge noted. Patient started on prednisone and hydroxyzine for 5 days
Age: 47.0
Sex: F
Vaccine: COVID19
Symptoms: Headache
Clinical narrative: Patient experiencing headache approximately 5 to 10 minutes after receiving 2nd dose of Moderna COVID-19 vaccine.  Patient reports having a headache that lasted for about an hour following the 1st dose of the vaccine four weeks prior.  At 3:10pm:  HR=71  O2 sat= 98%   122/65.  At 3:21pm:  BP=119/62.  Headache subsiding.  At 3:31pm:  BP=105/59, HR=63   O2 sat=99%.  Patient clinically stable.  Patient released from clinic at 3:32pm.
Age: 71.0
Sex: F
Vaccine: COVID19
Symptoms: Cardiac arrest, Intensive care, Resuscitation
Clinical narrative: Cardiac Arrest with in an hour of receiving Covid vaccine; Brought into ED by EMS doing CPR; resuscitation continued in ED for 20 minutes before ROSC was achieved.  Pt admitted to Critical Care.
Age: 46.0
Sex: M
Vaccine: COVID19, COVID19
Symptoms: Blood glucose normal, Fatigue, Feeling abnormal, Full blood count normal, Glycosylated haemoglobin
Clinical narrative: headaches for 20+ days, fatigue; brain fog and vertigo that still continue 38 days now.
Age: 46.0
Sex: M
Vaccine: COVID19, COVID19
Symptoms: Headache, Renal function test normal, Urine analysis normal, Vertigo
Clinical narrative: headaches for 20+ days, fatigue; brain fog and vertigo that still continue 38 days now.
Age: 46.0
Sex: M
Vaccine: COVID19, COVID19
Symptoms: Blood pressure increased, Blood pressure measurement, Echocardiogram, Electroencephalogram, Eye disorder
Clinical narrative: headaches for 20+ days, fatigue; brain fog and vertigo that still continue 38 days now.
Age: 46.0
Sex: M
Vaccine: COVID19, COVID19
Symptoms: Fatigue, Feeling abnormal, Headache, Loss of consciousness, Magnetic resonance imaging
Clinical narrative: headaches for 20+ days, fatigue; brain fog and vertigo that still continue 38 days now.
Age: 46.0
Sex: M
Vaccine: COVID19, COVID19
Symptoms: Meniere's disease, Vertigo
Clinical narrative: headaches for 20+ days, fatigue; brain fog and vertigo that still continue 38 days now.
Age: 51.0
Sex: F
Vaccine: COVID19
Symptoms: Chills, Pyrexia
Clinical narrative: fever chills
Age: 58.0
Sex: M
Vaccine: COVID19
Symptoms: Headache, Pain in extremity, Peripheral swelling
Clinical narrative: Mild headache Pain and swelling in arm Mild RA pain in left hand
Age: 86.0
Sex: M
Vaccine: COVID19
Symptoms: Body temperature increased, Gait disturbance, Incontinence, Pain
Clinical narrative: Patient was up at 6 AM on morning following injection. Temp 101.7. Difficulty mobilizing. Could straight leg raise. O2 sat was 94. B/P 170/70. Through out day has had some improvement. Incontinent (rare for Him) Achy. Sensorium unchanged.
Age: 39.0
Sex: F
Vaccine: COVID19
Symptoms: Blood test abnormal, Blood urine present, Culture urine, Cystitis, Dizziness
Clinical narrative: Pain in arm was so bad I was unable to  use my arm for several hours.  Was treated five times for a bladder infection, was determined that their was blood in my urine. Being referred to urology. Had to take Benadryl and ibuprofen for swelling of face and neck.  Burning of urinary tract has been extremely bad and still has not  subsided. Still having very bad flare ups of these symptoms including severe nauseas and dizziness (vertigo).  Having to eat bland foods and take Pepto everyday.  Severe Fatigue.  10 days ago I was sent home from work due to feeling bad and looking ill (very pale).  Hospital wanted to keep me overnight.
Age: 39.0
Sex: F
Vaccine: COVID19
Symptoms: Fatigue, Feeling abnormal, Full blood count, Impaired work ability, Nausea
Clinical narrative: Pain in arm was so bad I was unable to  use my arm for several hours.  Was treated five times for a bladder infection, was determined that their was blood in my urine. Being referred to urology. Had to take Benadryl and ibuprofen for swelling of face and neck.  Burning of urinary tract has been extremely bad and still has not  subsided. Still having very bad flare ups of these symptoms including severe nauseas and dizziness (vertigo).  Having to eat bland foods and take Pepto everyday.  Severe Fatigue.  10 days ago I was sent home from work due to feeling bad and looking ill (very pale).  Hospital wanted to keep me overnight.
Age: 39.0
Sex: F
Vaccine: COVID19
Symptoms: Pain in extremity, Pallor, SARS-CoV-2 test negative, Swelling, Swelling face
Clinical narrative: Pain in arm was so bad I was unable to  use my arm for several hours.  Was treated five times for a bladder infection, was determined that their was blood in my urine. Being referred to urology. Had to take Benadryl and ibuprofen for swelling of face and neck.  Burning of urinary tract has been extremely bad and still has not  subsided. Still having very bad flare ups of these symptoms including severe nauseas and dizziness (vertigo).  Having to eat bland foods and take Pepto everyday.  Severe Fatigue.  10 days ago I was sent home from work due to feeling bad and looking ill (very pale).  Hospital wanted to keep me overnight.
Age: 39.0
Sex: F
Vaccine: COVID19
Symptoms: Urinary tract discomfort, Vertigo
Clinical narrative: Pain in arm was so bad I was unable to  use my arm for several hours.  Was treated five times for a bladder infection, was determined that their was blood in my urine. Being referred to urology. Had to take Benadryl and ibuprofen for swelling of face and neck.  Burning of urinary tract has been extremely bad and still has not  subsided. Still having very bad flare ups of these symptoms including severe nauseas and dizziness (vertigo).  Having to eat bland foods and take Pepto everyday.  Severe Fatigue.  10 days ago I was sent home from work due to feeling bad and looking ill (very pale).  Hospital wanted to keep me overnight.
Age: 30.0
Sex: F
Vaccine: COVID19
Symptoms: Fatigue, Headache, Nausea, Pain in extremity, Pyrexia
Clinical narrative: 8am: fatigue, sore arm. 12pm: extreme fatigue, really sore arm, fever. 4pm: extreme fatigue, really sore arm, fever, nausea. 8pm: extreme fatigue, really sore arm, fever, nausea, headache. 8am 1/21: totally fine.
Age: 45.0
Sex: F
Vaccine: COVID19
Symptoms: Erythema, Injection site rash, Rash macular
Clinical narrative: Red, blotchy rash at the injection site.
Age: 37.0
Sex: M
Vaccine: COVID19
Symptoms: Impaired work ability, Vertigo
Clinical narrative: 3 days after receiving vaccine, started to have episodes of vertigo that last as long as 2 hours. 6 days after vaccination, he continues to have episodes of vertigo limiting his ability to return to work.
Age: 79.0
Sex: F
Vaccine: COVID19
Symptoms: Blood test, Canalith repositioning procedure, Diarrhoea, Dizziness, Head discomfort
Clinical narrative: Felt fine the day of event, during the night she felt like she had a heavy head, but when she woke up around 8:00 and she realized that something was very wrong, she could not sit up due to nausea and the room spinning.  She texted her daughter who is a nurse and got there about 1:00 PM, she was still in bed.  When she tried to sit her up she felt like she was going to throw up.  She put her legs over to the side of the bed, and she felt like somebody was pushing her with her daughter over a cliff, in a tornado and on a Ferris wheel.  She started vomiting and having diarrhea.  She had heard about an epley maneuver and after a time she sat her up again and still had the previous feeling of going off a mountain in a tornado.  She did the epley maneuver and tilter her head to the left and was still very dizzy but not as bad.  She then tilted her head to the right and it was not as bad.   Things started to settle down and eventually she was able to get up, still nauseated but 90% better.  She was able to go to the restroom with her daughter's help.  She stayed in the bed all that day and finally in the evening was abler to keep food down.   She limited her distance to the bed to the bathroom.   Her doctor was notified and called in some nausea  and vertigo medicine (meclizine), which he did and only took 2 doses of that.  The next morning she went up and down the stairs to make sure she was able to.  She was very, very cautious but each day has been better.  On 2/2/21 she called and got an APT with ENT but will not see him in a couple of weeks.  They are going to send a therapist tomorrow to evaluate her for the vertigo.  She is scheduled for the 2nd vaccine on 2/11/21.   Saw her internist today and he evaluated her and did 2 blood tests and sent the referral for the therapist to come tomorrow.
Age: 79.0
Sex: F
Vaccine: COVID19
Symptoms: Nausea, Vertigo, Vomiting
Clinical narrative: Felt fine the day of event, during the night she felt like she had a heavy head, but when she woke up around 8:00 and she realized that something was very wrong, she could not sit up due to nausea and the room spinning.  She texted her daughter who is a nurse and got there about 1:00 PM, she was still in bed.  When she tried to sit her up she felt like she was going to throw up.  She put her legs over to the side of the bed, and she felt like somebody was pushing her with her daughter over a cliff, in a tornado and on a Ferris wheel.  She started vomiting and having diarrhea.  She had heard about an epley maneuver and after a time she sat her up again and still had the previous feeling of going off a mountain in a tornado.  She did the epley maneuver and tilter her head to the left and was still very dizzy but not as bad.  She then tilted her head to the right and it was not as bad.   Things started to settle down and eventually she was able to get up, still nauseated but 90% better.  She was able to go to the restroom with her daughter's help.  She stayed in the bed all that day and finally in the evening was abler to keep food down.   She limited her distance to the bed to the bathroom.   Her doctor was notified and called in some nausea  and vertigo medicine (meclizine), which he did and only took 2 doses of that.  The next morning she went up and down the stairs to make sure she was able to.  She was very, very cautious but each day has been better.  On 2/2/21 she called and got an APT with ENT but will not see him in a couple of weeks.  They are going to send a therapist tomorrow to evaluate her for the vertigo.  She is scheduled for the 2nd vaccine on 2/11/21.   Saw her internist today and he evaluated her and did 2 blood tests and sent the referral for the therapist to come tomorrow.
Age: 72.0
Sex: F
Vaccine: COVID19
Symptoms: Injection site pruritus, Injection site urticaria
Clinical narrative: One week from the vaccine injection I am getting itching hives at the injection site.  All I have done so far is put cortisone on the hives. I don't seem to have any other symptoms.  Just very itchy arm.
Age: 61.0
Sex: F
Vaccine: COVID19
Symptoms: Injection site erythema, Injection site induration, Injection site pain, Injection site pruritus, Pain
Clinical narrative: after the pain, itching and swelling  subsided, I developed a 3 inch round red area that is hard, itchy and is tender to touch
Age: 61.0
Sex: F
Vaccine: COVID19
Symptoms: Pruritus, Swelling
Clinical narrative: after the pain, itching and swelling  subsided, I developed a 3 inch round red area that is hard, itchy and is tender to touch
Age: 43.0
Sex: M
Vaccine: COVID19
Symptoms: Chills, Eye irritation, Hyperhidrosis, Pyrexia
Clinical narrative: Ever since the 3rd day after taking the 2nd shot.  I have had about a degree of fever during the day and night.  Every night since last Tuesday January 27th I have woken up drenched in sweat multiple times a night.  Assuming this is a fever breaking.  I reported this to my doctor today and he advised me to go to this site.  If it continues I will see him next week. I have also had chills and eyes burning during the day ever since the 2nd shot.  The day after the 2nd shot my fever went to 101.5.  But I did not think that irregular since I heard that was a possibility.  The days after though I dont think are a regular vaccine event.
Age: 46.0
Sex: F
Vaccine: COVID19
Symptoms: Computerised tomogram head, Headache, SARS-CoV-2 test negative
Clinical narrative: Had a severe headache that has never gone away. Jan 1st went to ER
Age: 82.0
Sex: F
Vaccine: UNK
Symptoms: Chills, Headache, Pain, Pyrexia
Clinical narrative: Bodyache Chills Fever Headache Symptoms- headache and slight body ache began the first day but fever, chills and bodyache developed after 1 week from taking the vaccination.
Age: 52.0
Sex: F
Vaccine: COVID19
Symptoms: Arthralgia, Cellulitis, Chills, Fatigue, Groin pain
Clinical narrative: 1/19/2021 - sudden onset of chills, headache, muscle pain , joint pain (all joints) & extreme fatigue - continued thru 1/21/2021 1/21/2021 - joint pain resolved, headache & chills, headache & some muscle pain remained - but right groin & inside of right knee were intensely painful & a rash developed on right shin. Rash spread to back of right lower leg & because painful & hot. I called my PCP & went to the ER mid afternoon.
Age: 52.0
Sex: F
Vaccine: COVID19
Symptoms: Headache, Inflammatory marker increased, Laboratory test, Myalgia, Rash
Clinical narrative: 1/19/2021 - sudden onset of chills, headache, muscle pain , joint pain (all joints) & extreme fatigue - continued thru 1/21/2021 1/21/2021 - joint pain resolved, headache & chills, headache & some muscle pain remained - but right groin & inside of right knee were intensely painful & a rash developed on right shin. Rash spread to back of right lower leg & because painful & hot. I called my PCP & went to the ER mid afternoon.
Age: 52.0
Sex: F
Vaccine: COVID19
Symptoms: Skin warm, Ultrasound scan
Clinical narrative: 1/19/2021 - sudden onset of chills, headache, muscle pain , joint pain (all joints) & extreme fatigue - continued thru 1/21/2021 1/21/2021 - joint pain resolved, headache & chills, headache & some muscle pain remained - but right groin & inside of right knee were intensely painful & a rash developed on right shin. Rash spread to back of right lower leg & because painful & hot. I called my PCP & went to the ER mid afternoon.
Age: 65.0
Sex: F
Vaccine: COVID19
Symptoms: Arthralgia, Body temperature increased, Chills, Fatigue, Headache
Clinical narrative: 16 hours: awakened at 1:30am with joint pain; 19 hours 99.4 temp; 26 hours: 100.5 temp and chills continuing through day and night; 34 hours: 102 temp, fatigue; 40.5 hours: awakened with severe headache, fever continues; 46 hours (7am) sweating for about 10 minutes and then all symptoms were completely gone. I took Tylenol or Advil every 4-5 hours. The fever never went down even after taking the Tylenol.
Age: 65.0
Sex: F
Vaccine: COVID19
Symptoms: Hyperhidrosis, Sleep disorder
Clinical narrative: 16 hours: awakened at 1:30am with joint pain; 19 hours 99.4 temp; 26 hours: 100.5 temp and chills continuing through day and night; 34 hours: 102 temp, fatigue; 40.5 hours: awakened with severe headache, fever continues; 46 hours (7am) sweating for about 10 minutes and then all symptoms were completely gone. I took Tylenol or Advil every 4-5 hours. The fever never went down even after taking the Tylenol.
Age: 78.0
Sex: F
Vaccine: COVID19
Symptoms: Erythema, Rash, Skin warm, Swelling
Clinical narrative: Warm to touch,  red, swollen rash.
Age: 69.0
Sex: F
Vaccine: COVID19
Symptoms: Rash, Urticaria
Clinical narrative: I started noticing a bumpy rash on upper arms about a week after the injection.  It is not particularly itchy nor red, it?s many little bumps, but it?s persistent and now seems to be spreading to my lower arms.
Age: 24.0
Sex: F
Vaccine: COVID19
Symptoms: Body temperature fluctuation, Chills, Fatigue, Injection site erythema, Injection site pain
Clinical narrative: 12:30am-7:30am- Chills, fever, muscle aches, nausea, fatigue, soreness and red warm skin at injection site. 7:30-2:30pm Extreme fatigue. Temperature variability from fever to normal temp. Slept from 10:00am-2:30 which is extremely abnormal.
Age: 24.0
Sex: F
Vaccine: COVID19
Symptoms: Injection site warmth, Myalgia, Nausea, Pyrexia, Sleep disorder
Clinical narrative: 12:30am-7:30am- Chills, fever, muscle aches, nausea, fatigue, soreness and red warm skin at injection site. 7:30-2:30pm Extreme fatigue. Temperature variability from fever to normal temp. Slept from 10:00am-2:30 which is extremely abnormal.
Age: 60.0
Sex: F
Vaccine: COVID19
Symptoms: Heart rate increased, Paraesthesia, Paraesthesia oral
Clinical narrative: Tingling in tongue, feet, fingers approx 5-10 immediately  after injection. The day after injection. Feelings of Adrenaline rush, increase heart rate. Waking many times at night with same episodes. PCP Prescribed Predisone and Benadryl . some symptoms  still remain 3 weeks out.
Age: 21.0
Sex: F
Vaccine: COVID19
Symptoms: Injection site macule, Rash maculo-papular
Clinical narrative: Maculopapular rash all over area where vaccine was given and has spread across chest, upper back, neck and other shoulder. Not painful, mildly itchy.
Age: 30.0
Sex: F
Vaccine: COVID19
Symptoms: Chills, Eye swelling, Headache, Injection site erythema, Injection site induration
Clinical narrative: Minimal side effects day of/after injection (01/20/21): headache, chills. No further side effects until 01/27/21: dull headache began; swelling, itching, redness, firmness around injection site lasting until 01/28; eye swelling evening of 01/28. Swelling brought under control with benadryl, but dull headache persists until today 02/03.
Age: 30.0
Sex: F
Vaccine: COVID19
Symptoms: Injection site pruritus, Injection site swelling, Peripheral swelling, Telemedicine
Clinical narrative: Minimal side effects day of/after injection (01/20/21): headache, chills. No further side effects until 01/27/21: dull headache began; swelling, itching, redness, firmness around injection site lasting until 01/28; eye swelling evening of 01/28. Swelling brought under control with benadryl, but dull headache persists until today 02/03.
Age: 70.0
Sex: F
Vaccine: COVID19
Symptoms: Unevaluable event
Clinical narrative: ModernaCOVID-19 Vaccine EUA
Age: 96.0
Sex: F
Vaccine: COVID19
Symptoms: COVID-19, Chest X-ray normal, Cough, Dyspnoea, Failure to thrive
Clinical narrative: Pt receieved her first dose of the Moderna COVID-19 on 12/29/2020.  Lot number, route, and site not specified in medical record.  No record of 2nd dose was found on medical record review.  Pt was admitted to reporting hospital 2/2/2021 with an admitting diagnosis of failure to thrive/poor oral intake.  Pt was reported in ER to have a sore throat, cough, shortness of breath, and general recent decline.  Reported that pt and others in family had GI like illness about a week ago.  Admission test for COVID was positive per PCR NP swab on 2/2/2021.  Pt still currently admitted.
Age: 96.0
Sex: F
Vaccine: COVID19
Symptoms: General physical health deterioration, Hypophagia, Oropharyngeal pain, SARS-CoV-2 test positive
Clinical narrative: Pt receieved her first dose of the Moderna COVID-19 on 12/29/2020.  Lot number, route, and site not specified in medical record.  No record of 2nd dose was found on medical record review.  Pt was admitted to reporting hospital 2/2/2021 with an admitting diagnosis of failure to thrive/poor oral intake.  Pt was reported in ER to have a sore throat, cough, shortness of breath, and general recent decline.  Reported that pt and others in family had GI like illness about a week ago.  Admission test for COVID was positive per PCR NP swab on 2/2/2021.  Pt still currently admitted.
Age: 69.0
Sex: F
Vaccine: COVID19
Symptoms: Erythema, Hyperhidrosis, Pain, Skin warm
Clinical narrative: 3? by 2? red swelling, hot to touch, sore..this is 9 days after it is still the same
Age: 33.0
Sex: M
Vaccine: COVID19
Symptoms: Dizziness, Flushing, Tachycardia
Clinical narrative: After vaccination, patient felt light headed and sought us out.  Patient had not eaten since breakfast, and then had a protein shake.  He did have some water/fluids prior to arrival. Patient was flushed, dizzy, lightheaded, and tachycardic.  Patient placed in recumbent position and Given water/juice    Initial vitals- 145/85 pulse 115 O2 98% sats   Patient felt much improved with fluids and a snack.   Discharge Vitals- 135/85  Pulse 90; did not recheck O2 sat   Patient discharged in stable condition.
Age: 81.0
Sex: F
Vaccine: COVID19, COVID19
Symptoms: Guillain-Barre syndrome, Hypoaesthesia, Muscular weakness, Paraesthesia
Clinical narrative: Around 1/27/21 patient noticed numbness of bilateral legs and progressive weakness.  Admitted to hospital 1/29/21 and diagnosed with Guillen Barre.  Initially paresthesia was from feet to groin and has been improving.
Age: 81.0
Sex: F
Vaccine: COVID19, COVID19
Symptoms: CSF test, Guillain-Barre syndrome
Clinical narrative: Around 1/27/21 patient noticed numbness of bilateral legs and progressive weakness.  Admitted to hospital 1/29/21 and diagnosed with Guillen Barre.  Initially paresthesia was from feet to groin and has been improving.
Age: 50.0
Sex: M
Vaccine: COVID19
Symptoms: Pyrexia, Swelling face, Urticaria
Clinical narrative: fevers followed by facial swelling and urticaria
Age: 37.0
Sex: F
Vaccine: COVID19, COVID19
Symptoms: Blood pressure increased, Feeling abnormal, Hypotension, Injection site erythema, Injection site pruritus
Clinical narrative: After 12 min of injection my ears were ringing and I felt weird, asked to lay down checked my BP which was elevated for me 160/90.  Injection site swelled approx 20 cm x 15cm red hot swollen and itchy for 10 days. In those 10 days I had multiple unexplained ringing of the ears with same funny feeling and checked my BP which was low 105/56. Those episodes carried on for the length of 14 days after vaccine #1 and only lasted for 2-3 min at a time.
Age: 37.0
Sex: F
Vaccine: COVID19, COVID19
Symptoms: Injection site swelling, Injection site warmth, Tinnitus
Clinical narrative: After 12 min of injection my ears were ringing and I felt weird, asked to lay down checked my BP which was elevated for me 160/90.  Injection site swelled approx 20 cm x 15cm red hot swollen and itchy for 10 days. In those 10 days I had multiple unexplained ringing of the ears with same funny feeling and checked my BP which was low 105/56. Those episodes carried on for the length of 14 days after vaccine #1 and only lasted for 2-3 min at a time.
Age: 37.0
Sex: F
Vaccine: COVID19, COVID19
Symptoms: Arthralgia, Dizziness, Pelvic pain, Tinnitus
Clinical narrative: After 12 min of injection my ears were ringing and I felt weird, asked to lay down checked my BP which was elevated for me 160/90.  Injection site swelled approx 20 cm x 15cm red hot swollen and itchy for 10 days. In those 10 days I had multiple unexplained ringing of the ears with same funny feeling and checked my BP which was low 105/56. Those episodes carried on for the length of 14 days after vaccine #1 and only lasted for 2-3 min at a time.
Age: 35.0
Sex: F
Vaccine: COVID19, COVID19
Symptoms: Hypoaesthesia, Limb discomfort, Peripheral swelling
Clinical narrative: Wednesday evening Right arm felt heavy 3 hours after vaccination, right had went numb that night.  Next day on Thursday,  Left hand went numb and had swelling in both hands.  On Friday. Right arm was numb from hand to elbow and left hand continued to be numb.  Went to the emergency room and was given high dose steroids and sent home on  prednisone.
Age: 35.0
Sex: F
Vaccine: COVID19, COVID19
Symptoms: Demyelination, Neurological examination
Clinical narrative: Wednesday evening Right arm felt heavy 3 hours after vaccination, right had went numb that night.  Next day on Thursday,  Left hand went numb and had swelling in both hands.  On Friday. Right arm was numb from hand to elbow and left hand continued to be numb.  Went to the emergency room and was given high dose steroids and sent home on  prednisone.
Age: 50.0
Sex: M
Vaccine: COVID19
Symptoms: Chills, Pain, Peripheral swelling, Pyrexia
Clinical narrative: 1day after shot:Fever,chills, body ache.  2 days after shot: Symptoms from day before gone but noticed a Tennis ball sized lump under left arm/pit area.  One week and one day after shot: slight swelling under left arm/pit area.
Age: 24.0
Sex: F
Vaccine: COVID19
Symptoms: Abdominal pain upper, Dizziness, Epistaxis, Headache, Injection site pain
Clinical narrative: With the second dose I felt arm pain at the injection site and muscle pains, my whole body was aching, specially my arms, both of them. My upper body in general (from the waist up) it was very painful, very hard to carry stuff. The next day I started with nose bleeds. I was feeling a little dizzy throughout the day. I believe because of the blood loss (substantial). I had headache and felt nauseous throughout the day. The nose bleed was very very heavy, I don't have nose bleeds. It started getting better with each day and it lasted about 6 days.