Age: 52.0
Sex: F
Vaccine: COVID19, COVID19
Symptoms: Computerised tomogram abnormal, Condition aggravated, Neck pain, Urine analysis normal
Clinical narrative: Joint pain/every major joint was hurting, bith sides ankles, knees, hips, tail bone, elbow and base of my neck; Appendicitis; This case was initially received via an unknown source (no reference has been entered for a regulatory authority or license partner) on 18-Mar-2021. The most recent information was received on 17-Apr-2021 and was forwarded to Moderna on 17-Apr-2021.    This spontaneous case was reported by a consumer (subsequently medically confirmed) and describes the occurrence of APPENDICITIS (Appendicitis) and ARTHRALGIA (Joint pain/every major joint was hurting, bith sides ankles, knees, hips, tail bone, elbow and base of my neck) in a 52-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 039K20A and 23M20A) for COVID-19 vaccination.     The patient's past medical history included Irritable bowel syndrome (IBS with Constipation.) since 22-Aug-1968, Undifferentiated connective tissue disease since 05-Jan-2015 and Arthritis. Concurrent medical conditions included Drug allergy (Ibuprofen, Magnesium sulfate Allergy) and Thalassemia since 22-Aug-1968. Concomitant products included APREMILAST (OTEZLA) from 13-Apr-2021 to an unknown date for Arthritis, HYDROXYCHLOROQUINE SULFATE (PLAQUENIL [HYDROXYCHLOROQUINE SULFATE]) from 04-Jan-2015 to an unknown date for Autoimmune disorder.   On 04-Feb-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 04-Mar-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 08-Mar-2021, the patient experienced APPENDICITIS (Appendicitis) (seriousness criteria hospitalization and medically significant). On 05-Apr-2021, the patient experienced ARTHRALGIA (Joint pain/every major joint was hurting, bith sides ankles, knees, hips, tail bone, elbow and base of my neck) (seriousness criterion hospitalization). The patient was hospitalized from 08-Mar-2021 to 09-Mar-2021 due to APPENDICITIS and ARTHRALGIA. At the time of the report, APPENDICITIS (Appendicitis) had resolved with sequelae and ARTHRALGIA (Joint pain/every major joint was hurting, bith sides ankles, knees, hips, tail bone, elbow and base of my neck) had not resolved.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On 08-Mar-2021, Computerised tomogram: appendicitis appendicitis. On 08-Mar-2021, Urine analysis: Negative.     The action taken with mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown) was unknown.       The patient was treated with Otezla for arthritis flare. On 08-mar-2021, the patient had a surgery to remove appendix.   Most recent FOLLOW-UP information incorporated above includes: On 17-Apr-2021: Follow-up information included patient demographics, dose details, concomitant medications, historical conditions, event outcome, new event.; Sender's Comments: Although a temporal association exists, based on the current available information, mechanism of action of mRNA-1237 vaccine and the pathogenesis process of appendicitis, the event of appendicitis is assessed as unlikely related. The causality for the event of arthralgia is assessed as likely related.