Sex: F
Vaccine: COVID19
Symptoms: Myocardial infarction, Postural orthostatic tachycardia syndrome, Transient ischaemic attack
Clinical narrative: postural orthostatic tachycardia syndrome; heart attacks; mini-stroke; This spontaneous case was reported by a consumer and describes the occurrence of POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME (postural orthostatic tachycardia syndrome), MYOCARDIAL INFARCTION (heart attacks) and TRANSIENT ISCHAEMIC ATTACK (mini-stroke) in a female patient of an unknown age who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 prophylaxis.     No Medical History information was reported.   In March 2021, the patient received dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. In April 2021, received dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On an unknown date, the patient experienced POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME (postural orthostatic tachycardia syndrome) (seriousness criterion hospitalization), MYOCARDIAL INFARCTION (heart attacks) (seriousness criteria hospitalization and medically significant) and TRANSIENT ISCHAEMIC ATTACK (mini-stroke) (seriousness criteria hospitalization and medically significant). At the time of the report, POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME (postural orthostatic tachycardia syndrome), MYOCARDIAL INFARCTION (heart attacks) and TRANSIENT ISCHAEMIC ATTACK (mini-stroke) was resolving.        For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown), the reporter did not provide any causality assessments.   It was not reported that patient had any relevant medical history or conditions, allergy, concomitant diseases and risk factor.  It was unknown if the patient received any other vaccines in the 4 weeks prior to COVID-19 vaccine.  Concomitant product use was not provided by the reporter.  Suspect vaccine dosage text was reported as unknown.  After receiving two doses of the Moderna vaccine in March and April of 2021, she began experiencing health issues, and was eventually diagnosed with postural orthostatic tachycardia syndrome, a condition wherein her heart and her blood pressure did not work in accordance with each other. She had since had multiple heart attacks and a mini-stroke, and had to have a pacemaker to correct her ailing heart, an organ all records show was in good health prior to being inoculated against Covid-19.  Company Comment: This is a spontaneous case concerning a female patient of an unknown age with no reported medical history, who experienced the unexpected, serious (due to medically significant and hospitalization) AESIs of myocardial infarction, and transient ischaemic attack and the unexpected, serious (due to hospitalization) AESI of postural orthostatic tachycardia syndrome. The events occurred on an unknown date, after a dose of mRNA-1273 vaccine (it was reported that the patient was vaccinated on March and April, 2021; however, date for vaccination, dose number and onset date of the events were not provided; hence, latency could not be estimated). She had to have a pacemaker to correct her ailing heart. No further details about the clinical course, diagnostic procedures and treatments were provided. The outcome of the events was reported as resolving. The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report.