Sex: F
Vaccine: TYP
Symptoms: Arthralgia, Joint swelling, Mobility decreased, Nightmare
Clinical narrative: SWELLING AND PAIN IN HER JOINTS; SWELLING AND PAIN IN HER JOINTS; DIFFICULTY IN USING JOINTS; VIVID NIGHTMARES; This spontaneous case (PVX2019-1084) was received from a consumer on 02-May-2019. It describes a female consumer who developed swelling and pain in her joints and had vivid nightmares, after the administration of Vivotif for an unknown indication.  Case report: The consumer took doses of Vivotif on 18-Apr-2019, 20-Apr-2019, 22-Apr-2019, and 24-Apr-2019. She developed swelling and pain in her joints. Initially the swelling was in the knees, and later also occurred in hands and wrists. She reported that the swelling went away after two days, but when she took the next dose, it flared up again. On 22-Apr-2019, after taking the third dose she had vivid nightmares. As per her physician, these events were a normal part of the immune response and she should be worried if it does not resolves on its own.  She took 2 dose of oral ibuprofen (200 mg: once a day) for swelling and pain.  The consumer had no other medical conditions.  Concomitant medications  included oral levothyroxine (75 mcg/ 0.075  once a day) for an unknown indication, calcium, fish oil, turmeric, Vitamin D, Vitamin A, melatonin (at night) and 5-Hydroxytryptophan (5-HTP) at night.  Action taken with Vivotif was dosage maintained.  The consumer had recovered from the events of swelling and pain in her joints, and vivid nightmares.  Company's Comment: In this case, it was reported that the consumer developed swelling and pain in her joints and had vivid nightmares, after the administration of Vivotif. There seems to be a temporal association between the intake of the vaccine and the events. Hence, the causality of the events with Vivotif is assessed as possible.  Follow-up information has been extracted from VAERS on 30-Jul-2019.  The demographic details has been updated as age: 71-year.  It was reported the consumer was taking oral Vivotif (lot number: 3003248). The consumer additionally experienced "difficulty in using joints" (PT: mobility decreased) but not severe enough to stop taking the vaccine.  The consumer was additionally taking salmon oil, glucosamine/ chondroitin, calcium citrate, vitamin D3, concomitantly at the time of report.  Consumer's medical history included adverse reaction (extreme headache and vomiting) to Oxycontin (oxycodone) & related opioids.  The consumer was allergic to cat.  The consumer was recovered from the event "difficulty in using joints".  Company's Comment: In this case, it was reported that the consumer developed swelling and pain in her joints, difficulty in using joints and had vivid nightmares, after the administration of Vivotif. There seems to be a temporal association between the intake of the vaccine and the events. Hence, the causality of the events with Vivotif is assessed as possible.; Sender's Comments: Company's Comment: In this case, it was reported that the consumer developed swelling and pain in her joints, difficulty in using joints and had vivid nightmares, after the administration of Vivotif. There seems to be a temporal association between the intake of the vaccine and the events. Hence, the causality of the events with Vivotif is assessed as possible.