Sex: F
Vaccine: VARZOS, VARZOS, VARZOS
Symptoms: Fatigue, Herpes zoster, Inflammatory marker increased, Malaise, Post herpetic neuralgia
Clinical narrative: Shingles; post herpetic neuralgia; feeling of malaise.; Pain in breast; feeling tired; Fever; Chills; burning sensation all over body; dry rash; inflammation markers high; This non-serious case was reported by a consumer via call center representative and described the occurrence of shingles in a female patient who received Herpes zoster (Shingrix) for prophylaxis.   Previously administered products included Shingrix with an associated reaction of fatigue (1st dose received on an unknown date).   On 11-JUN-2024, the patient received the 2nd dose of Shingrix (right arm). In JUN-2024, 1 week after receiving Shingrix, the patient experienced shingles (Verbatim: Shingles), post herpetic neuralgia (Verbatim: post herpetic neuralgia), malaise (Verbatim: feeling of malaise.), breast pain (Verbatim: Pain in breast), tiredness (Verbatim: feeling tired), fever (Verbatim: Fever), chills (Verbatim: Chills), burning sensation (Verbatim: burning sensation all over body), rash (Verbatim: dry rash) and inflammatory marker increased (Verbatim: inflammation markers high). The patient was treated with valaciclovir (Valacyclovir). The outcome of the shingles, breast pain, chills, burning sensation, rash and inflammatory marker increased were not reported and the outcome of the post herpetic neuralgia was not resolved and the outcome of the malaise, tiredness and fever were resolved.   It was unknown if the reporter considered the shingles, post herpetic neuralgia, malaise, breast pain, tiredness, fever, chills, burning sensation, rash and inflammatory marker increased to be related to Shingrix.     It was unknown if the company considered the shingles, post herpetic neuralgia, malaise, breast pain, tiredness, fever, chills, burning sensation, rash and inflammatory marker increased to be related to Shingrix.   Additional Information: GSK Receipt Date: 03-SEP-2024 Consumer called to provide additional information regarding adverse events experienced after receiving 2nd dose of Shingrix. Consumer stated she received her 2nd dose of Shingrix 11 June 2024 in her right arm. Consumer stated that her symptoms appeared one week after vaccination. Consumer stated she began experiencing pain under her right breast. She experienced a feeling of being tired and malaise, fever and chills. She stated she developed a burning skin sensation all over her body as well. Consumer never broke out in a rash or developed lesions. Consumer did stated that she had a slightly dry rash all over her body. She was seen by her Healthcare professional three different times for diagnosis. The 3rd time she went to her HCP the HCP did a blood test and the inflammation markers were really high. The name of the test was ESR and her SED rates were noted to be 39. Upon seeing the results of the blood test her HCP diagnosed her as having had Shingles (Lack of effect.) The HCP prescribed Valacyclovir I gram to be taken 3 effect. The HCP prescribed Valacyclovir I gram to be taken 3 times daily for 10 days. The consumer stated she was on the last day of treatment with the Valacyclovir and was experiencing a burning sensation on parts of her body. Consumer stated she looked this up online and felt she was experiencing post herpetic neuralgia (PHN). Consumer stated her fever was gone and her energy level was starting to come back and she did not feel as tired anymore. Of note, the consumer stated that when she received her first dose of Shingrix (date not provided) she experienced being tired and feeling of malaise.