Age: 70.0
Sex: F
Vaccine: COVID19, COVID19
Symptoms: Genital blister, Injection site pain, Laboratory test, Pruritus, Pustule
Clinical narrative: blisters/talking legs, arms, hands, palm of my hands, soles of my feet, back and front torso, and last but certainly not least, they even grew on my lady parts / more lesions came fast and furious all over my body; having a terrible reaction to the booster (Monovalent); itchy; filled with pus and blood; This spontaneous case was reported by a patient and describes the occurrence of BLISTER (blisters/talking legs, arms, hands, palm of my hands, soles of my feet, back and front torso, and last but certainly not least, they even grew on my lady parts / more lesions came fast and furious all over my body), PRURITUS (itchy), PUSTULE (filled with pus and blood) and VACCINATION COMPLICATION (having a terrible reaction to the booster (Monovalent)) in a 70-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 017B22A, 058E21A, 030A21A and 004M20A) for COVID-19 prophylaxis.     Patient was very healthy.  Concurrent medical conditions included Dry eyes. Concomitant products included CICLOSPORIN (RESTASIS) for Dry eyes.   On 11-Feb-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 11-Mar-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 25-Oct-2021, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 22-Aug-2022, received fourth dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. In 2022, the patient experienced PRURITUS (itchy) and PUSTULE (filled with pus and blood). In August 2022, the patient experienced VACCINATION COMPLICATION (having a terrible reaction to the booster (Monovalent)). On 25-Aug-2022, the patient experienced BLISTER (blisters/talking legs, arms, hands, palm of my hands, soles of my feet, back and front torso, and last but certainly not least, they even grew on my lady parts / more lesions came fast and furious all over my body). The patient was treated with PREDNISONE for Blisters, at a dose of 10 milligram. At the time of the report, BLISTER (blisters/talking legs, arms, hands, palm of my hands, soles of my feet, back and front torso, and last but certainly not least, they even grew on my lady parts / more lesions came fast and furious all over my body), PRURITUS (itchy), PUSTULE (filled with pus and blood) and VACCINATION COMPLICATION (having a terrible reaction to the booster (Monovalent)) had not resolved.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On an unknown date, Biopsy: Results of both indicate no infection and no underlying conditions. On an unknown date, Blood test: Results of both indicate no infection and no underlying conditions.     For mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular), the reporter did not provide any causality assessments.   It was reported that on 22 Aug 2022, Patient received second COVID booster shot and to be clear, Patient had a total of 4 shots. Patient was expecting a reaction similar to those patient experienced after her other shots, chills, fatigue, arm pain, etc. It was reported on 23 Aug 2021 patient had experienced arm was sore from the injection site, fatigue and chills and on 24 Aug 2021 started and had blisters that looked like pimples and they filled with puss, started getting all over patient body, hands, feet, itchy, painful, pus filled.  Reportedly, patient side-effect was completely different and devastating. Three days after shot, patient began developed blisters and hey were small at first and only a few, so was not concerned. But over a short period of time, the small ones grew bigger, more lesions came fast and furious all over body, they filled with pus and blood and became so itchy, patient was contemplating rolling body across a large sheet of sandpaper and patient was not exaggerating when she said everywhere on her body. Since nothing in life had changed, no new foods introduced or no new cosmetics or detergents, Patient feared the booster was the culpruit. This issue had patient medical team baffled.   It was reported that both lab tests offered fodder for patient suspicion and indicated that a reaction to the vaccine was likely the cause. Patient reached out today because patient still suffered with an active case of whatever it was that happened to body.   Patient did not require any prescription medication (except prednisone), Patient exercise regularly, pay attention to diet, and luckily avoided contracting COVID before or after the introduction of the life saving vaccine.  Patient was included a picture of the lesions before the prednisone kicked in and patient was prepared to supply any additional information that will help you help patient get to the bottom of this conundrum. Patient eagerly awaited a response.  It was reported that patient cannot stay on prednisone for an extended period of time, so patient had to figure out what the heck was going on and how to make it stop. This outreach was a plea for help.   Patient was on forth course of prednisone. When the dosage was high, 20milligrams or higher, the lesions subside. But when dose was tappered to 10 milligrams as patient current dosage, they reappear and came right back. Patient cannot take another vaccination and patient was afraid to get the flu vaccine.   This case was linked to MOD-2022-685675 (Patient Link).   Most recent FOLLOW-UP information incorporated above includes: On 08-Dec-2022: Live follow-up received contains non significant information. Previous doses information and Batch/lot number of suspect product was updated. Narrative was updated.