Age: 54.0
Sex: F
Vaccine: VARZOS
Symptoms: Asthenia, Blood creatinine increased, Cervical spinal stenosis, Dysarthria, Dysmetria
Clinical narrative: unable to walk; spinal stenosis in the lumbar region; left ID of the hip; worsening left hip pain/chronic left hip pain; morbid obesity; bilateral finger parasthesias and dysmetria; C6-C7 canal and neural foraminal stenosis; djd of left hip; Left hip wound: wound vac in place; neural foraminal stenosis; unable to work; elevated inflammatory markers; Guillain-Barre syndrome; polyneuropathy; Dysmetria; weakness; slurred speech; acute kidney injury; left septic hip; This serious case was reported by a consumer via patient support programs and described the occurrence of guillain barre syndrome in a 56-year-old female patient who received Herpes zoster (Shingrix) for prophylaxis.   The patient's past medical history included gastric bypass.   On 16-FEB-2022, the patient received Shingrix 50 ug. In AUG-2022, between 6 and 7 months after receiving Shingrix, the patient experienced septic joint (Verbatim: left septic hip) (serious criteria hospitalization and medically significant), acute kidney injury (Verbatim: acute kidney injury) (serious criteria hospitalization and medically significant) and slurred speech (Verbatim: slurred speech) (serious criteria hospitalization). On an unknown date, the patient experienced guillain barre syndrome (Verbatim: Guillain-Barre syndrome) (serious criteria hospitalization and medically significant), polyneuropathy (Verbatim: polyneuropathy) (serious criteria hospitalization and medically significant), dysmetria (Verbatim: Dysmetria) (serious criteria hospitalization and medically significant), weakness (Verbatim: weakness) (serious criteria hospitalization), unable to walk (Verbatim: unable to walk) (serious criteria hospitalization), lumbar spinal stenosis (Verbatim: spinal stenosis in the lumbar region) (serious criteria hospitalization), joint disorder (Verbatim: left ID of the hip) (serious criteria hospitalization), pain in hip (Verbatim: worsening left hip pain/chronic left hip pain) (serious criteria hospitalization), morbid obesity (Verbatim: morbid obesity) (serious criteria hospitalization), paresthesia of fingers (Verbatim: bilateral finger parasthesias and dysmetria) (serious criteria hospitalization), cervical spinal stenosis (Verbatim: C6-C7 canal and neural foraminal stenosis) (serious criteria hospitalization and medically significant), degenerative joint disease (Verbatim: djd of left hip) (serious criteria hospitalization), hip injury (Verbatim: Left hip wound: wound vac in place) (serious criteria hospitalization), vertebral foraminal stenosis (Verbatim: neural foraminal stenosis) (serious criteria hospitalization), inability to work (Verbatim: unable to work) (serious criteria hospitalization) and inflammatory marker increased (Verbatim: elevated inflammatory markers) (serious criteria hospitalization). The patient was treated with gabapentin. The outcome of the guillain barre syndrome, unable to walk and paresthesia of fingers were not resolved and the outcome of the septic joint, polyneuropathy, acute kidney injury, dysmetria, weakness, slurred speech, lumbar spinal stenosis, joint disorder, pain in hip, morbid obesity, cervical spinal stenosis, degenerative joint disease, hip injury, vertebral foraminal stenosis, inability to work and inflammatory marker increased were not reported.   It was unknown if the reporter considered the guillain barre syndrome, septic joint, polyneuropathy, acute kidney injury, dysmetria, weakness, slurred speech, unable to walk, lumbar spinal stenosis, joint disorder, pain in hip, morbid obesity, paresthesia of fingers, cervical spinal stenosis, degenerative joint disease, hip injury, vertebral foraminal stenosis, inability to work and inflammatory marker increased to be related to Shingrix.     It was unknown if the company considered the guillain barre syndrome, septic joint, polyneuropathy, acute kidney injury, dysmetria, weakness, slurred speech, unable to walk, lumbar spinal stenosis, joint disorder, pain in hip, morbid obesity, paresthesia of fingers, cervical spinal stenosis, degenerative joint disease, hip injury, vertebral foraminal stenosis, inability to work and inflammatory marker increased to be related to Shingrix.   Additional Information: Receipt Date: 15-AUG-2023 The patient reported that she was in hospital due to guillain-Barre syndrome which was still ongoing. On 28 July (year unspecified) the patient was seen for a pre procedure with diagnosis of spinal stenosis in lumbar region. On 19 August (year unspecified) she had left hip pain which worsened, and she was admitted for her ID left hip. The patient was referred for infectious disease consultation. The patient was experiencing weakness and slurred speech. The patient had friends over and they called emergency services. The patient was taken by ambulance to the hospital. When the patient was there, they suspected that she had a stroke. They worked her up, but everything came back negative. She was sent to inpatient rehabilitation. She had been either in rehabilitation, both acute and sub-acute or the hospital for over a year. The patient was still unable to walk without assistance. The patient had been unable to work. It had completely changed her life. In August 2022, she came with left septic hip and acute kidney injury reporting slurred speech for one day. The patient did complain of bilateral finger parasthesias and dysmetria at the time of that hospitalization. In addition, had slurred speech. An MRI was performed without acute process. Noted worsening symptoms of the hand. Gabapentin was ordered at 300 milligrams three times per day. MRI of the cervical spine revealed C6-C7 canal stenosis, and no cord signal abnormality was noted. She had electro diagnostic study to evaluate for a neuropathic process and reported that she had severe polyneuropathy, consistent with Guillain Barre.  This study did not indicate that this was an ongoing process and that reinnervation potentials were noted. The clinic visit impression was reported as GBS of unknown etiology, DJD of left hip with infectious process noted, left hip wound: wound vac in place. would need evaluation by therapy. Neuropathy was reported as would review old records to identify etiologies. This was an abnormal study. There was electrodiagnostic evidence for a length dependent, axonal, sensorimotor polyneuropathy. There was no electrodiagnostic evidence for demyelination. After discharge some of the patient was told that she could follow up in May of 2023. The last conversation was with the family in November.  The reporter consented to follow up.