Age: 64.0
Sex: F
Vaccine: COVID19, PPV
Symptoms: Myoclonus, Pyrexia
Clinical narrative: She also feels she is becoming forgetful.; Not wanting to move; skin crawls/big roaches crawling under my skin; Not feeling well; Currently she feels like she has a temperature; She has started, as of last night, to have unintentional movements,jerks, and quirks; She has also started having involuntary muscle movements or tweaking starting yesterday; 3 days of slight fever; This spontaneous case was reported by a consumer and describes the occurrence of MEMORY IMPAIRMENT (She also feels she is becoming forgetful.), BRADYKINESIA (Not wanting to move), DYSKINESIA (She has also started having involuntary muscle movements or tweaking starting yesterday), FORMICATION (skin crawls/big roaches crawling under my skin) and MYOCLONUS (She has started, as of last night, to have unintentional movements,jerks, and quirks) in a 64-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 019B21A, 030A21A and 015M20A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.    Co-suspect product included non-company product PNEUMOCOCCAL VACCINE for Pneumonia.    The patient's past medical history included Heart attack. Concurrent medical conditions included Sciatica (chronic sciatica with 3 bulging herniated disks.), Alzheimer's disease (symptoms of Alzheimer's) and Schizophrenia (seen 12 psychiatrists at a nearby clinic). Concomitant products included DIAZEPAM for Alzheimer's disease, OXYCODONE HYDROCHLORIDE (OXYCONTIN) for Sciatica, PARACETAMOL (TYLENOL 8 HOUR), CLOPIDOGREL BISULFATE (PLAVIX), METOPROLOL, SIMVASTATIN, SERTRALINE HYDROCHLORIDE (ZOLOFT), ALPRAZOLAM and CARIPRAZINE HYDROCHLORIDE (VRAYLAR) for an unknown indication.   On 03-Mar-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 31-Mar-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 15-Oct-2021, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. On 20-Dec-2021, the patient received dose of PNEUMOCOCCAL VACCINE (unknown route) 1 dosage form. On 20-Dec-2021, the patient experienced DYSKINESIA (She has also started having involuntary muscle movements or tweaking starting yesterday), MYOCLONUS (She has started, as of last night, to have unintentional movements,jerks, and quirks) and PYREXIA (Currently she feels like she has a temperature). On an unknown date, the patient experienced MEMORY IMPAIRMENT (She also feels she is becoming forgetful.), BRADYKINESIA (Not wanting to move), FORMICATION (skin crawls/big roaches crawling under my skin), MALAISE (Not feeling well) and PYREXIA (3 days of slight fever). At the time of the report, MEMORY IMPAIRMENT (She also feels she is becoming forgetful.), BRADYKINESIA (Not wanting to move), DYSKINESIA (She has also started having involuntary muscle movements or tweaking starting yesterday), FORMICATION (skin crawls/big roaches crawling under my skin), MYOCLONUS (She has started, as of last night, to have unintentional movements,jerks, and quirks), MALAISE (Not feeling well) and PYREXIA (Currently she feels like she has a temperature) outcome was unknown and PYREXIA (3 days of slight fever) had resolved.            patient said that she had been feeling withdrawal symptoms due to a change in her medication from diazepam to alprazolam and she ran out of her medicine a week ago so she had stopped taking it. She started feeling ill and she is currently going through the 2nd day of withdrawal and she says "it's not fun." It has caused a lot of unnecessary, erratic movement. It has now been 2 days since she had slept properly. She felt very sick and she was in 7 days of agony, patient said that her symptoms were due to the alprazolam and that it just happened to coincide with the Moderna booster dose she received.   Concomitant medication includes medication for schizophrenia and 2 psych medications and 2 pain medications  Patient saw her NP yesterday where her medication was switched from diazepam to alprazolam or a generic for xanax, which she is not taking currently (Alprazolam). She also received her pneumococcal pneumonia vaccine yesterday and currently she feels like she has a temperature. She also stated she has been previously put on a medication for schizophrenia, and has seen 12 psychiatrists at a nearby clinic. Patient reported that she did not have any history of bipolar disorder or seizures.   This case was linked to MOD-2021-421493, MOD-2021-421502 (Patient Link).   Reporter did not allow further contact   Most recent FOLLOW-UP information incorporated above includes: On 22-Dec-2021: Follow up received and it contains significant information about condition and her events and concomitant medications were updated.