Age: 23.0
Sex: F
Vaccine: COVID19
Symptoms: Cytokine test, Flow cytometry, Immunohistochemistry, Lymphadenopathy
Clinical narrative: Acute kidney injury; axillary lymphadenopathy; This literature-non-study case was reported in a literature article and describes the occurrence of ACUTE KIDNEY INJURY (Acute kidney injury) in a 23-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.   The patient's past medical history included Eczema. Concurrent medical conditions included Asthma and Hypothyroidism.   On an unknown date, the patient received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On an unknown date, received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On an unknown date, the patient experienced ACUTE KIDNEY INJURY (Acute kidney injury) (seriousness criterion medically significant) and LYMPHADENOPATHY (axillary lymphadenopathy). The patient was treated with DEXAMETHASONE for Lymphadenopathy and Acute kidney injury, at an unspecified dose and frequency and ANAKINRA for Lymphadenopathy and Acute kidney injury, at an unspecified dose and frequency. At the time of the report, ACUTE KIDNEY INJURY (Acute kidney injury) and LYMPHADENOPATHY (axillary lymphadenopathy) had resolved.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On an unknown date, Biopsy: an excisional biopsy of the left axillary lymph no (abnormal) An excisional biopsy of the left axillary lymph node was performed. The H&E sections of the enlarged lymph nodes show hyperplastic follicles and marked paracortical expansion with polymorphic lymphohistiocytic infiltrate and hypervascularity and sinus histiocytosis.. On an unknown date, Biopsy bone marrow: a bone marrow biopsy was also performed and showed (abnormal) A bone marrow biopsy was also performed and showed a normocellular marrow with active trilineage hematopoiesis. No atypical lymphoid infiltrate or hemophagocytosis was detected. No immunophenotypical abnormality was detected.. On an unknown date, Body temperature: 104?f (Inconclusive) 104?F. On an unknown date, Computerised tomogram: ct scans showed left axillary lymphadenopathy, up (abnormal) CT scans showed left axillary lymphadenopathy, up to 2.1 cm, and multiple enlarged lymph nodes in the abdomen.. On an unknown date, Cytokine test: cytokine panel showed elevations in tnf alpha, (High) Cytokine panel showed elevations in TNF alpha, interferon gamma, interleukin-5, interleukin-10, interleukin-13, and interleukin-6.. On an unknown date, Flow cytometry: flow cytometry revealed no overt immunophenotypica (High) Flow cytometry revealed no overt immunophenotypical aberrancy. The CD4:CD8 ratio was slightly increased (4.0:1).. On an unknown date, Immunohistochemistry: by immunohistochemistry, the lymphoid cells are mi (Inconclusive) By immunohistochemistry, the lymphoid cells are mixed T-cells and B-cells with normal compartment. Marked perifollicular/interfollicular T cells hyperplasia are noted with intact T-cell antigens (positive for CD2, CD3, CD5, CD7, and mixed CD4 and CD8)..     For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown), the reporter considered ACUTE KIDNEY INJURY (Acute kidney injury) and LYMPHADENOPATHY (axillary lymphadenopathy) to be possibly related.    Concomitant medication was not reported.  After ruling out viral infections and hematolymphoid malignancy, a diagnosis of post-vaccination reactive lymphadenitis, with paracortical/interfollicular lymphoid, LC hyperplasia, and secondary hemophagocytosis was rendered.  This case concerns a 23 year old female patient with medical history of Eczema, Asthma and Hypothyroidism, who experienced the unexpected serious event of ACUTE KIDNEY INJURY, 1 week after the second dose of mRNA-1273 vaccine.  The patient also experienced non-serious event of LYMPHADENOPATHY, 1 week after the second dose of mRNA-1273 vaccine. The events were considered related to the vaccine per the reporter's assessment. The benefit-risk relationship of the vaccine is not affected by this report.; Sender's Comments: This case concerns a 23 year old female patient with medical history of Eczema, Asthma and Hypothyroidism, who experienced the unexpected serious event of ACUTE KIDNEY INJURY, 1 week after the second dose of mRNA-1273 vaccine.  The patient also experienced non-serious event of LYMPHADENOPATHY, 1 week after the second dose of mRNA-1273 vaccine. The events were considered related to the vaccine per the reporter's assessment. The benefit-risk relationship of the vaccine is not affected by this report.