Age: 78.0
Sex: U
Vaccine: COVID19
Symptoms: Herpes simplex reactivation, Nausea, Neuralgia
Clinical narrative: I developed intense neural pain in the fingertips of 4 fingers of one hand; nauseated; H. simplex reactivation/got a lesion on my lower lip, I believed it was a 'fever blister'; This spontaneous case was reported by a patient and describes the occurrence of NEURALGIA (I developed intense neural pain in the fingertips of 4 fingers of one hand), HERPES SIMPLEX REACTIVATION (H. simplex reactivation/got a lesion on my lower lip, I believed it was a 'fever blister') and NAUSEA (nauseated) in a 78-year-old patient of an unknown gender who received mRNA-1273.815 (SPIKEVAX 2023-2024) (batch no. ASKU) for COVID-19 prophylaxis.     The patient's past medical history included Fever blister. Previously administered products included for Shingles: Shingles vaccine (fully vaccinated against shingles, having received two doses of both the "old and" and of the newer Shingrex vaccines); for COVID-19 prophylaxis: Moderna (got 9 Covid shots and lately all Moderna-made). Past adverse reactions to the above products included No adverse effect with Moderna and Shingles vaccine. Concurrent medical conditions included Diabetes, Overweight and Calcium pyrophosphate dihydrate deposition disease. Concomitant products included PREDNISONE and COLCHICINE for Calcium pyrophosphate dihydrate deposition disease.    On 21-Mar-2024, the patient received dose of mRNA-1273.815 (SPIKEVAX 2023-2024) (unknown route) 1 dosage form. In March 2024, the patient experienced HERPES SIMPLEX REACTIVATION (H. simplex reactivation/got a lesion on my lower lip, I believed it was a 'fever blister'). On 21-Mar-2024,  after starting mRNA-1273.815 (SPIKEVAX 2023-2024), the patient experienced NEURALGIA (I developed intense neural pain in the fingertips of 4 fingers of one hand) and NAUSEA (nauseated). The patient was treated with IBUPROFEN for Neuralgia affecting finger tips, at an unspecified dose and frequency and VALACYCLOVIR [VALACICLOVIR] for Herpes simplex reactivation, at an unspecified dose and frequency. On 21-Mar-2024, NAUSEA (nauseated) had resolved. At the time of the report, NEURALGIA (I developed intense neural pain in the fingertips of 4 fingers of one hand) and HERPES SIMPLEX REACTIVATION (H. simplex reactivation/got a lesion on my lower lip, I believed it was a 'fever blister') outcome was unknown.        For mRNA-1273.815 (SPIKEVAX 2023-2024) (Unknown), the reporter did not provide any causality assessments.   It was unknown if the patient had received any other vaccines in the 4 weeks prior to COVID-19 vaccine.  The patient got 9 Covid shots, lately all Moderna-made. The patient had diabetes and overweight, so get a dose every 4 months or so.  The last time, for the first time, the patient developed (potential) side effects. First the patient got nauseated, 2-3 hours after the shot. Nausea passed during the next hour or so. But an hour later, developed intense neural pain in the fingertips of 4 fingers of one hand - never experienced anything similar before. Applied some ice, took Ibuprofen, was thinking about getting to urgent care, when the pain subsided. Five days later, got a lesion on lower lip; believed it was a 'fever blister' - had those in the past. The patient's family doctor also thought it was a H. simplex reactivation, and prescribed Valacyclovir; but pharmacist noticed that the lesion looked unusual and thought it might've been an aborted shingles attack. (The patient was fully vaccinated against shingles, having received two doses of both the "old," and of the newer Shingrix vaccines.)  The patient was currently on 5 mg prednisone and low-dose colchicine, because of a knee inflammation due to calcium pyrophosphate crystal deposition disease, was recently diagnosed with. The patient's rheumatologist did not know whether the patient could/should be vaccinated while on those anti-inflammatory drugs.