Age: 61.0
Sex: F
Vaccine: VARZOS, VARZOS
Symptoms: Differential white blood cell count, Diplopia, EGFR status assay, Encephalitis, Fatigue
Clinical narrative: NOTE: On July 24, 2018, I saw FNP-C, for my annual physical examination and was given an excellent report along with strong encouragement to get the SHINGRIX Shingles vaccine as soon as it was again available in their office. I received the vaccine on August 29, 2018. The adverse reaction began that evening (see timeline on Continuation Page).  Diagnosis: Vaccination encephalitis (G04.02). Diagnoses also included: muscle pain, post-vaccination fever, numbness and tingling, unsteady gait, lower abdominal pain, double vision, trembling/shaking of hands, spinal cord inflammation (meningomyelitis). Adverse Neurological Reaction to Shringrix Vaccine Date Adverse Events, Treatments, Outcomes 2018-08-29 (W) Received SHINGRIX Vaccine (LOT 3 MY2B2) (Nurse) 2018-08-30 (Th) At 2:00 a.m. I awoke shivering and feeling nauseous. Temp ~102. Began taking Acetaminophen, but temperature did not return to normal range and nausea continued. 2018-08-31 (F) Nausea subsided, but temperature remained in the 100+ range. 2018-09-01 to 2018-09-06 (Sat-Th) Felt tired. Temperature remained in the 99.5-101+ range. 2018-09-06 (Th) Began having severe stomach pain in a band around my abdomen and in central abdomen up into my chest. Also, an occasional pain in my left arm pit below the muscle where vaccine was injected. 2018-09-07 (F) Temperature creeping up in the 101+ range and nausea returning. 2018-09-08 (Sat) Temperature reached 103.2 accompanied by nausea. Went to visit PCP. Basic blood work was done and a stomach x-ray taken. I was advised to visit an ER if I was not feeling better in the morning. 2018-09-09 (Sun) Fever, nausea, double vision, and pain continuing. Went to ER. I was given a series of blood tests, one of which may have damaged a nerve in my right hand, along with an abdominal CT scan. Then, I was sent home with instructions to visit an ER at one of the larger hospitals for a neurological evaluation if I didn't feel better in the morning. Given Rx for Norco and Zofran. Body was beginning to feel numb, tingly, and painful and I was having trouble walking and maintaining balance. 2018-09-10 (M) Definitely not feeling well this morning. Body felt numb, tingly, and painful to touch from chest to toes. Could not walk without assistance. Hands trembling and shaking. Went to ER. The ER doctor seemed quite concerned about my condition as did the hospital doctor, and so I began another round of tests  several blood draws and a brain MRI with and w/o contrast. After these tests, I was admitted to the general floor of the hospital, and then a short time later transferred to the neurology floor. 2018-09-11 (T) Body still numb, tingly, painful, and weak. More tests: Blood draw, Lumbar Puncture, two spinal MRIs. 2018-09-12 (W) Pain subsiding, but still numb, tingly, and weak. Woke up with headache. 2018-09-13 (Th) Pain almost gone. Numbness and tingling reducing. Woke up with headache. Discharged from hospital. 2018-09-13 to 2018-09-18 (Th to T) Resting and recuperating at home. Each day the numbness and tingling are decreasing and I'm regaining strength and energy. Not completely recovered. 2018-09-21 Neurologist stated in may take two to four weeks to regain strength and energy, even though neurological symptoms seem to be improving. Long-term effects: unknown.