Age: 25.0
Sex: F
Vaccine: HPV4
Symptoms: Laboratory test abnormal, Loss of personal independence in daily activities, Menopause, Menstruation irregular, Mood swings
Clinical narrative: depression/attempted to take her own life/suicidal ideation; cataract/vision changes that causes difficulty seeing and driving at night; Autonomic, and Neurological injuries; Autonomic, and Neurological injuries; premature ovarian failure/menopause/hot flashes and night sweats/mood swings/chronic fatigue/interrupted sleep patterns, daily exhaustion/amenorrhea/unable to get pregnant; anxiety; osteopenia in her back/bones regularly ache, make crackly noises, and experiences weakness; hair loss/bald spots/autoimmune disorder; Information has been received from a lawyer regarding a case in litigation and referred to a currently adult female patient (pt) (exact age not provided). Her other medical history, concurrent conditions and concomitant therapies were not provided. On 26-APR-2013 (at the age of 25 years old), the pt was vaccinated with the first dose of quadrivalent human papillomavirus (Types 6,11,16,18) recomb. vaccine (GARDASIL) intramuscular injection (exact dose, route of administration, anatomical location, lot # and expiration date was not provided), as recommended by her health care provider, for prophylaxis (reported as for preventing cervical cancer). On 08-JUN-2013 (at the age of 25 years old), the pt was vaccinated with the second dose of quadrivalent human papillomavirus (Types 6,11,16,18) recomb. vaccine (GARDASIL) intramuscular injection (exact dose, route of administration, anatomical location, lot # and expiration date was not provided). On 15-OCT-2013 (at the age of 25 years old), the pt was vaccinated with the third dose of quadrivalent human papillomavirus (Types 6,11,16,18) recomb. vaccine (GARDASIL) intramuscular injection (exact dose, route of administration, anatomical location, lot # and expiration date was not provided). Post third-quadrivalent human papillomavirus (Types 6,11,16,18) recomb. vaccine (GARDASIL) vaccine, the pt developed mood swings. She frequently became irrationally and uncharacteristically angry. Post third-quadrivalent human papillomavirus (Types 6,11,16,18) recomb. vaccine (GARDASIL) vaccine, the pt experienced changes in her sleep patterns. She developed chronic fatigue and experienced daily exhaustion regardless of the number of hours of sleep. She could sleep for twelve or more hours and still not felt rested. Post third-quadrivalent human papillomavirus (Types 6,11,16,18) recomb. vaccine (GARDASIL) vaccine, she developed hot flashes and night sweats. Consequently, she must maintain two fans on while she slept. Post third-quadrivalent human papillomavirus (Types 6,11,16,18) recomb. vaccine (GARDASIL) vaccine, the pt developed vision changes that causes difficulty seeing and driving at night. Pt's menses became sporadic, abnormal, and eventually disappeared. After a series of tests, and doctors' visits, pt was diagnosed with premature ovarian failure (Premature menopause) and menopause. As follows, the doctors informed pt that she was unable to get pregnant. Following her diagnosis, pt sought treatments for her injuries, including bio-identical hormonal replacement therapy (BHRT). The treatment worked for a short period but resulted in many side-effects such as depression, anxiety, hair loss, and bald spots (Alopecia areata). At the height of the depression, pt attempted to take her own life (Depression suicidal). Furthermore, at age thirty, pt was diagnosed with cataract and osteopenia in her back. As a result, pt's bones regularly ache, make crackly noises, and experienced weakness. As the months progressed, so did pt's injuries. She was seen by multiple physicians and specialists for her complaints which now included: mood swings, chronic fatigue, interrupted sleep patterns, daily exhaustion, hot flashes, night sweats, cataracts, vision problems, amenorrhea, depression, anxiety, hair loss, bald spots, depression, suicidal ideation, aching bones, crackly bones, and weakness. Based upon her chronic and severe post-quadrivalent human papillomavirus (Types 6,11,16,18) recomb. vaccine (GARDASIL) symptoms, pt had been diagnosed with various medical conditions, including but not limited to, premature ovarian failure, menopause, cataracts, osteopenia in her back, depression, anxiety, and chronic fatigue. To this day, pt must complete blood work every 3 to 6 months to monitor her home levels in order to address the related issues of her mental health, hair loss, vision, bone health and sexual issues. Pt did not know and had no reason to know that the symptoms she was experiencing were caused by the quadrivalent human papillomavirus (Types 6,11,16,18) recomb. vaccine (GARDASIL) vaccine, as no such information was given to her by her medical providers. It was not until early 2014 that pt began to suspect that the quadrivalent human papillomavirus (Types 6,11,16,18) recomb. vaccine (GARDASIL) was the cause of her symptoms and injuries. As a result of her post-quadrivalent human papillomavirus (Types 6,11,16,18) recomb. vaccine (GARDASIL) symptoms, pt had been unable to engage in activities that a normal young person would enjoy. Post-quadrivalent human papillomavirus (Types 6,11,16,18) recomb. vaccine (GARDASIL) vaccines, pt was unable to become pregnant and create the family that she dreamt of. A majority of her time was spent in doctor offices and her injuries had negatively impacted her relationships. Pt contended that her quadrivalent human papillomavirus (Types 6,11,16,18) recomb. vaccine (GARDASIL) injections caused her to develop serious and debilitating autoimmune, autonomic, and neurological injuries, including but not limited to premature ovarian failure, menopause, cataracts, osteopenia in her back, depression, anxiety, and chronic fatigue, as well as a constellation of adverse symptoms, complications, injuries, and other adverse events, many of which were alleged herein and all of which were caused by quadrivalent human papillomavirus (Types 6,11,16,18) recomb. vaccine (GARDASIL) or otherwise linked to her quadrivalent human papillomavirus (Types 6,11,16,18) recomb. vaccine (GARDASIL)-induced autoimmune disorder (Autonomic nervous system imbalance; Nervous system disorder). As a proximate result of company's wrongful acts and omissions and its negligent and fraudulent testing, labeling, manufacturing, marketing and promotion of quadrivalent human papillomavirus (Types 6,11,16,18) recomb. vaccine (GARDASIL), the pt had suffered and continued to suffer severe and permanent physical injuries, and associated symptomology and had suffered severe and permanent emotional injuries, including pain and suffering. Pt also had a substantial fear of suffering additional and ongoing harms, including but not limited to now being at an increased risk of cancer, and future symptoms and harms associated with her injuries caused by quadrivalent human papillomavirus (Types 6,11,16,18) recomb. vaccine (GARDASIL). As a direct and proximate result of her quadrivalent human papillomavirus (Types 6,11,16,18) recomb. vaccine (GARDASIL)-induced injuries, pt had suffered and continued to suffer economic losses, including considerable financial expenses for medical care and treatment, and diminished income capacity, and she would continue to incur these losses and expenses in the future. The outcome of all events was considered to be not recovered. The lawyer considered all events to be related to quadrivalent human papillomavirus (Types 6,11,16,18) recomb. vaccine (GARDASIL).  The lawyer considered all events to be disabling.  Upon internal review, the events of depression suicidal, cataract were determined as medically significant.