Age: 73.0
Sex: F
Vaccine: COVID19
Symptoms: Urticaria chronic, Vaccination complication
Clinical narrative: massive hives everywhere including her side, upper ribs, hip, around her back, arms, legs, thighs, and buttocks/welts/chronic systemic urticaria; A severe reaction from the Moderna booster; hives were thick, and terribly itchy with a rash, but different from her first rash; hive came back to different places, were sometimes a red flatter thing, sometimes purpura; Shaking; her skin burns at night; stiff around her face and mouth; sometimes solid red portions, red flatter thing/fingertips are very red for a while then have a purplish color; her eyelids have a dark color around them particularly on the right side/ her hands look like a picture of Reynaud's syndrome and are white up; She feels her life is not normal and that it is not normal to have "serious symptoms" for months after receiving a vaccine; numb fingers, hands and feet; fatigue; This spontaneous case was reported by a consumer and describes the occurrence of URTICARIA CHRONIC (massive hives everywhere including her side, upper ribs, hip, around her back, arms, legs, thighs, and buttocks/welts/chronic systemic urticaria), VACCINATION COMPLICATION (A severe reaction from the Moderna booster), RASH PRURITIC (hives were thick, and terribly itchy with a rash, but different from her first rash), PURPURA (hive came back to different places, were sometimes a red flatter thing, sometimes purpura) and TREMOR (Shaking) in a 73-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 027D21A, 016M20A and 025L20A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     No Medical History information was reported.   On 22-Jan-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 19-Feb-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. On 03-Nov-2021, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to .25 milliliter. On 10-Nov-2021, the patient experienced URTICARIA CHRONIC (massive hives everywhere including her side, upper ribs, hip, around her back, arms, legs, thighs, and buttocks/welts/chronic systemic urticaria). In November 2021, the patient experienced VACCINATION COMPLICATION (A severe reaction from the Moderna booster), RASH PRURITIC (hives were thick, and terribly itchy with a rash, but different from her first rash), PURPURA (hive came back to different places, were sometimes a red flatter thing, sometimes purpura), TREMOR (Shaking), SKIN BURNING SENSATION (her skin burns at night), MUSCULOSKELETAL STIFFNESS (stiff around her face and mouth), ERYTHEMA (sometimes solid red portions, red flatter thing/fingertips are very red for a while then have a purplish color), SKIN DISCOLOURATION (her eyelids have a dark color around them particularly on the right side/ her hands look like a picture of Reynaud's syndrome and are white up), FEELING ABNORMAL (She feels her life is not normal and that it is not normal to have "serious symptoms" for months after receiving a vaccine), HYPOAESTHESIA (numb fingers, hands and feet) and FATIGUE (fatigue). The patient was treated with LORATADINE (CLARITIN [LORATADINE]) at an unspecified dose and frequency and PARACETAMOL (TYLENOL [PARACETAMOL]) at an unspecified dose and frequency. At the time of the report, URTICARIA CHRONIC (massive hives everywhere including her side, upper ribs, hip, around her back, arms, legs, thighs, and buttocks/welts/chronic systemic urticaria) had not resolved and VACCINATION COMPLICATION (A severe reaction from the Moderna booster), RASH PRURITIC (hives were thick, and terribly itchy with a rash, but different from her first rash), PURPURA (hive came back to different places, were sometimes a red flatter thing, sometimes purpura), TREMOR (Shaking), SKIN BURNING SENSATION (her skin burns at night), MUSCULOSKELETAL STIFFNESS (stiff around her face and mouth), ERYTHEMA (sometimes solid red portions, red flatter thing/fingertips are very red for a while then have a purplish color), SKIN DISCOLOURATION (her eyelids have a dark color around them particularly on the right side/ her hands look like a picture of Reynaud's syndrome and are white up), FEELING ABNORMAL (She feels her life is not normal and that it is not normal to have "serious symptoms" for months after receiving a vaccine), HYPOAESTHESIA (numb fingers, hands and feet) and FATIGUE (fatigue) outcome was unknown.            Patient height was reported as 5 1.5  No concomitant medications were reported.  Treatment medication also includes Anti-histamines  It was reported that, the patient administered the last dose in the vial for a booster dose of the vaccine but did not think there was anything wrong with her dose or the vaccine. 7 days after receiving the booster dose. portions. She spoke to a healthcare professional who stated her "urticaria" may possibly have developed into chronic systemic urticaria.All these symptoms had occurred every day starting 1 week after receiving the booster. Patient stated that her hands look like a picture of Reynaud's syndrome and are white up until the first knuckle at the top while the inside of her hands. The patient continued to take unspecified antihistamines. She was concerned for blood dis orders, inflammation, and autoimmune disorders because of the vaccine. The patient was never previously been diagnosed with COVID-19. She had never experienced any of these symptoms prior to receiving the vaccine.   This case was linked to MOD-2022-483243, MOD-2022-483265 (Patient Link).   Most recent FOLLOW-UP information incorporated above includes: On 14-Feb-2022: Updated reporter's details, patient's height, suspected product details and route of administration, treatment medications, additional events were added added and narrative updated.