Sex: M
Vaccine: TYP
Symptoms: Abdominal discomfort, Immunisation, Oral administration complication, Vomiting
Clinical narrative: THREW UP THE THIRD DOSE; STOMACH UPSET; TOOK TWO DOSES ON THE SAME DAY; This spontaneous case report was received from another healthcare professional (PVX2019-695) on 21-Mar-2019. It described a 34-year-old male consumer who threw up the third dose and experienced stomach upset following the intake of Vivotif capsule for an unknown indication. The consumer also "took two doses on the same day".  The consumer's medical history included Gastrooesophageal reflux disease (GERD).   The consumer's concomitant medications included Adderall (dextroamphetamine and amphetamine; 20 mg), Protonix (40 mg), Phenergan (promethazine; 25 mg), testosterone injection (200 mg/ ml) and Peridex (chlorhexidine; 0.12% solution) for an unknown indication.   It was reported that the consumer took the first two doses of Vivotif after which he was fine but when he took the third dose on 20-Mar-2019, he experienced stomach upset and threw up. He saw the whole capsule in the vomit, so he took the fourth dose on the same day.   He did not take any treatment medication for the events.  The action taken with Vivotif with respect to the events threw up the third dose and stomach upset was dosage maintained while with respect to the event "took two doses on the same day" was not applicable.  The clinical outcome of the events threw up the third dose and stomach upset was resolved while with respect to the event "took two doses on the same day" was unknown.  Company's Comment: In this case, it was reported that a 34-year-old male consumer "threw up the third dose and experienced stomach upset" following the intake of Vivotif. There seems to be a temporal association between the intake of the vaccine and the events. However, the intake of first two doses of Vivotif vaccine were uneventful. Also, the events threw up the third dose and experienced stomach upset can be explained by patient's past medical history of GERD (Gastrooesophageal reflux disease) and multiple concomitant medications like Adderall (dextroamphetamine and amphetamine; 20 mg), Protonix (40 mg), Phenergan (promethazine; 25 mg), testosterone injection (200 mg/ ml) and Peridex which provides a plausible explanation for the reported events.The causality of the event "took two doses on the same day" was considered as not applicable. ; Sender's Comments: Company's Comment: In this case, it was reported that a 34-year-old male consumer "threw up the third dose and experienced stomach upset" following the intake of Vivotif. There seems to be a temporal association between the intake of the vaccine and the events. However, the intake of first two doses of Vivotif vaccine were uneventful. Also, the events threw up the third dose and experienced stomach upset can be explained by patient's past medical history of GERD (Gastrooesophageal reflux disease) and multiple concomitant medications like Adderall (dextroamphetamine and amphetamine; 20 mg), Protonix (40 mg), Phenergan (promethazine; 25 mg), testosterone injection (200 mg/ ml) and Peridex which provides a plausible explanation for the reported events..The causality of the event "took two doses on the same day" was considered as not applicable.