Age: 18.0
Sex: M
Vaccine: HPVX, MENB
Symptoms: Chills, Fatigue, Hyperhidrosis, Malaise, Pain
Clinical narrative: not feel well; pain; fatigue; chills; fever; sweaty; This case was reported by a consumer via call center representative and described the occurrence of fatigue in a 18-year-old male patient who received Men B NVS (Bexsero) for prophylaxis.   Co-suspect products included HPV 16-18 (HPV vaccine) for prophylaxis.   Previously administered products included HPV vaccine (received 2 doses without any problem) and Menveo.   On 24th July 2019 11:30, the patient received the 1st dose of Bexsero and the 3rd dose of HPV vaccine. On 24th July 2019, 1 days after receiving Bexsero and HPV vaccine, the patient experienced fever and sweating. On 24th July 2019 23:30, the patient experienced fatigue and chills. On 25th July 2019, the patient experienced pain. On 26th July 2019, the patient experienced feeling unwell. The patient was treated with ibuprofen (Motrin), paracetamol (Tylenol) and non-drug therapy, non-drug therapy (Ice Pack (No Medication)). On an unknown date, the outcome of the fatigue, chills, fever, pain and sweating were recovered/resolved and the outcome of the feeling unwell was not recovered/not resolved.   The reporter considered the fatigue, chills, fever, pain, sweating and feeling unwell to be related to Bexsero. It was unknown if the reporter considered the fatigue, chills, fever, pain, sweating and feeling unwell to be related to HPV vaccine.  Additional details were reported as follows: The patient's mother reported for the patient. The patient received the first Bexsero vaccine as part of his routine vaccination because he was attending college. The reporter clarified that he did receive the third part of HPV series at the same time and on the same arm where he got Bexsero vaccine. However, he did not have any reaction to the other two HPV vaccine that he received in the past; so at this point, they were only suspecting that the events are due to the Bexsero vaccine.  Later on the same day of receiving Bexsero vaccine, on that evening, the patient complained about unusual fatigue and around 11:30 PM at night he had the chills.  The patient had a fever of 101.6 degrees F at 3:30 AM. The reporter gave him Motrin 1,000 mg and called her health plan that has someone working 24/7 for advice. They told her to take him to emergency room if the temperature goes over 104 degrees F. The patient's temperatures escalated to 102 and again, it was 103 within 40 minutes after calling the health plan. The patient seemed to be in pain. The reporter got some compressed ice and took his temperature again. Within 15 or 20 minutes of making that phone call, his temperature were over 104 degrees. She took her son to the emergency room (ER). At the ER, her son had his temperature taken rectally and they were 102.8 degrees. He was given fluids and stayed for an hour at the ER. They discharged him on both Motrin and Tylenol staggered every 3 hours (alternating both medications every 3 hours). The patient was sweaty and had fever (of 99.8 degrees F) the entire day. The physician reported this event to the CDC.  The reporter consented for follow up.