Sex: U
Vaccine: VARZOS
Symptoms: Injection site pain, Product closure issue, Product complaint
Clinical narrative: Pain at Injection Site; Product Complaint; Product stopper coring; This case was reported by a pharmacist and described the occurrence of injection site pain in a adult patient who received Herpes zoster (Shingrix) for prophylaxis. This case was associated with a product complaint.   On an unknown date, the patient received Shingrix at an unknown dose. On an unknown date, unknown after receiving Shingrix, the patient experienced injection site pain, pharmaceutical product complaint and product stopper coring. On an unknown date, the outcome of the injection site pain, pharmaceutical product complaint and product stopper coring were unknown.   It was unknown if the reporter considered the injection site pain to be related to Shingrix.   Rerun  Additional details were provided as follows: The age at vaccination was not applicable for this report. The age group of the patient was not reported, but selected as an adult as per vaccine indication. The pharmacist reported difficulty inserting needle through rubber stopper of several Shingrix antigen vials. It was reported that, adjuvant vial was somewhat difficult to insert needle through rubber stopper; however, the antigen vial was significantly more difficult to puncture. The caller reported this difficulty to insert needle through stopper was a big difference from previous Shingrix vaccines.  The caller reported ordering a new box of syringes assuming the syringe was the issue; however, same difficulty occurred.  The caller reported that, there was no difficulty, while giving other vaccines using newly ordered box of syringes. The caller mentioned that, changing syringes(needle) in between mixing, and reported the antigen rubber stopper still causes needle to become dull and therefore difficult to puncture the skin upon administration. The caller reported that, there was something inside the middle of circle in rubber stopper of antigen, which stopping needle from piercing through the vial.  Additional details were provided as follows: The age at vaccination was not applicable for this report. The age group of the patient was not reported, but selected as an adult as per vaccine indication. The pharmacist reported difficulty inserting needle through rubber stopper of several Shingrix antigen vials. It was reported that, adjuvant vial was somewhat difficult to insert needle through rubber stopper; however, the antigen vial was significantly more difficult to puncture. The caller reported this difficulty to insert needle through stopper was a big difference from previous Shingrix vaccines.  The caller reported ordering a new box of syringes assuming the syringe was the issue; however, same difficulty occurred.  The caller reported that, there was no difficulty, while giving other vaccines using newly ordered box of syringes. The caller mentioned that, changing syringes(needle) in between mixing, and reported the antigen rubber stopper still causes needle to become dull and therefore difficult to puncture the skin upon administration. The caller reported that, there was something inside the middle of circle in rubber stopper of antigen, which stopping needle from piercing through the vial.