Sex: F
Vaccine: FLUX
Symptoms: Fatigue, Full blood count normal, Lung consolidation, Renal function test normal
Clinical narrative: Initial information received on 17-Jul-2018 regarding an unsolicited valid serious case issued from a literature article. Introduction: Anti-Neutrophilic Cytoplasmic Antibody (ANCA)-associated vasculitis post flu-vaccine is a rare entity. Whether it is because of lack recognition or underreporting is unclear. It is difficult to determine the at risk group for ANCA-vasculitis associated with flu vaccine. To our knowledge this is the 9th reported case of ANCA-vasculitis due to flu vaccine. This case involves a 75 years old female patient who experienced anti-neutrophilic cytoplasmic antibody (anca)-associated vasculitis, while she received vaccine INFLUENZA VACCINE. The patient's past medical history, medical treatment(s), vaccination(s) and family history were not provided. Notes: CAT scan of the chest done five months prior to this presentation was essentially unremarkable. On an unknown date, the patient received a dose of suspect INFLUENZA VACCINE produced by unknown manufacturer lot number not reported. On an unknown date, the patient developed a serious anti-neutrophilic cytoplasmic antibody (anca)-associated vasculitis (vasculitis) (antineutrophil cytoplasmic antibody positive) following the administration of INFLUENZA VACCINE. This event was assessed as medically significant. On an unknown date, the patient developed a serious sudden onset fatigue (fatigue) three weeks following the administration of INFLUENZA VACCINE. This event was assessed as medically significant. On an unknown date, the patient developed a serious extreme dyspnea with minimal exertion (dyspnoea) three weeks following the administration of INFLUENZA VACCINE. This event was assessed as medically significant. (Other relevant tests included CBC and renal function were both unremarkable. A CAT scan showed diffuse bilateral patchy consolidation with coalesced nodularity in the upper and mid lung fields. All respiratory cultures were negative. Vasculitis workup was positive for cytoplasmic-ANCA (c-ANCA)). Final diagnosis was anti-neutrophilic cytoplasmic antibody (ANCA)-associated vasculitis. It was not reported if the patient received a corrective treatment. The patient outcome is reported as Unknown for anti-neutrophilic cytoplasmic antibody (anca)-associated vasculitis, as Unknown for sudden onset fatigue, as Unknown for extreme dyspnea with minimal exertion and as Unknown for anti-neutrophilic cytoplasmic antibody (anca)-associated vasculitis.; Sender's Comments: This case involves a 75 years old female patient who experienced anti-neutrophilic cytoplasmic antibody (anca)-associated vasculitis, while she received vaccine INFLUENZA VACCINE (unknown manufacturer). Time to onset is unknown. CAT scan showed diffuse bilateral patchy consolidation with coalesced nodularity in the upper and mid lung fields. Additional information including patient's medical history, medical condition at the time of vaccination, etiological workup and investigation reports to identify alternative etiology are needed for complete assessment of the case. Based on available information role of a vaccine cannot be assessed.