Sex: F
Vaccine: FLUX
Symptoms: Exposure during pregnancy, Lower respiratory tract infection, Pyrexia, Uterine contractions during pregnancy
Clinical narrative: Initial unsolicited report received from the literature on 08-AUG-2018. This case was linked with the case 2018SA220375 (same reporter). The following is the abstract from the article: Background: Other than influenza, little is known about the consequences of viral acute respiratory illness (ARI) on pregnant women and fetuses. Our objectives were to determine the frequency of ARI due to respiratory viruses and the associated clinical outcomes during pregnancy. Methods. Pregnant women in their second or third trimester were enrolled if they reported having symptoms of ARI or were healthy within the preceding 2 weeks. Nasopharyngeal secretions were evaluated for respiratory viruses by molecular diagnostic assays. Clinical outcomes were evaluated at enrollment and via a follow-up telephone-based questionnaire 2 weeks later. Results. There were 155 pregnant participants, with 81 ARI cases and 91 healthy controls. Acute lower respiratory tract illness (ALRTI) was identified in 29 cases (36%). Human rhinovirus (HRV), respiratory syncytial virus (RSV), and influenza virus accounted for 75% of virus-positive cases of ALRTI. Cases with ALRTI often reported a longer duration of illness, history of allergies, symptoms of wheezing, shortness of breath, or chest pain, and use of prescription medication. Two cases with ALRTI reported decreased fetal movement; a third case with ALRTI was hospitalized. Conclusions. In over one third of ARI cases, participants had symptoms consistent with ALRTI. Infection with HRV, RSV, or influenza virus was commonly detected in patients with ALRTI. Viral ALRTI during pregnancy appears to be common and is associated with significant morbidity. Keywords. Maternal respiratory viral infection; respiratory tract infection; maternal vaccination; respiratory syncytial virus; influenza; rhinovirus. This case involves an adult female patient (age not reported), who was vaccinated with a dose of INFLUENZA VACCINE (Batch number, expiry date, dose, dose in series, route and site of administration were not reported) on an unspecified date, while she was pregnant (exposure during pregnancy). Pregnancy information regarding gestation period at onset, LMP was not reported. Patient's medical history was not reported. Concomitant medications were not reported. On an unknown date, following the vaccination, the patient developed acute lower respiratory tract illness (ALRTI). Patient presented with uterine contractions and fever. On an unknown date patient was hospitalized. The patient other relevant lab tests and other corrective treatment were not reported. The outcome of all the events were not reported. List of documents held by sender: none. Sender's Comments: This case concerns an adult pregnant female who was vaccinated with INFLUENZA vaccine (unknown manufacturer) and presented with acute lower respiratory tract illness. The time to onset is unknown. More information regarding nature of the event and patient's personal and historical information are not provided. Based upon the reported information, the role of the vaccine cannot be assessed.