Sex: M
Vaccine: FLUX
Symptoms: Culture stool negative, Endoscopy normal, HIV test negative, Hepatitis viral test negative, Hepatocellular injury
Clinical narrative: ferritin was found to be > 40,000 mcg/L; ferritin was found to be > 40,000 mcg/L; hypertriglyceridemia to 2285 mg/dL; hepatocellular injury; deranged Liver function tests (LFT); Initial information received on 03-Oct-2019 regarding an unsolicited valid serious case issued from a literature article.  This case involves a 65 years old male patient who experienced ferritin was found to be > 40,000 mcg/l (Hyperferritinaemia), hypertriglyceridemia to 2285 mg/dl (Hypertriglyceridaemia) and hepatocellular injury (Hepatocellular injury), while he received vaccine INFLUENZA VACCINE.  The patient's past medical history, medical treatment(s), vaccination(s) and family history were not provided.  At the time of the event, the patient had ongoing nausea, vomiting, diarrhoea, in the setting of 15 lbs weight decreased, Hyperferritinaemia, Cytopenia and Liver function test abnormal.   On an unknown date, the patient received a dose of suspect INFLUENZA VACCINE produced by unknown manufacturer lot number not reported via unknown route in unknown administration site.  On an unknown date, the patient developed a serious ferritin was found to be > 40,000 mcg/l (hyperferritinaemia and condition aggravated), hypertriglyceridemia to 2285 mg/dl (hypertriglyceridaemia) and hepatocellular injury with deranged liver function tests (LFT) (liver function test abnormal), less than 24 hours following the administration of INFLUENZA VACCINE. The patient was hospitalized for these events.  Relevant laboratory test results included: Biopsy liver - On an unknown date:  [hepatocellular injury but no hemophagocytosis] Blood triglycerides - On an unknown date: 2285 mg/dL Serum ferritin increased - On an unknown date: >1000 mcg/L; on an unknown date: >40,000 mcg/L  It was reported that there was no lymphadenopathy on exam. Hemochromatosis DNA testing was negative. Magnetic Resonance Imaging of brain, Computed Tomography of chest, abdomen, pelvis, and upper and lower endoscopies were non-contributory. Test including, but not limited to, blood culture, hepatitis panel, human immunodeficiency virus, acetaminophen level, stool culture, C. difficile PCR as well as soluble CD25 returned negative.   Other relevant tests included Bone marrow biopsy was also without hemophagocytosis and otherwise normocellular.  Final diagnosis was hepatocellular injury, hypertriglyceridemia to 2285 mg/dl and ferritin was found to be > 40,000 mcg/l.  It was reported the patient did not received any corrective treatment.  The outcome of the events was reported as recovered (values returned to baseline spontaneously over the span of just 4 days).  List of documents held by sender: none.; Sender's Comments: This case involves a 65 years old male patient who presented with hyperferritinemia, hypertriglyceridemia, liver function test abnormal,  after vaccination. Time to onset is compatible with the role of vaccine. More details regarding patient's previous vaccination history,  etiological workup and investigation reports to identify alternative etiology are needed for complete assessment of the case. Based on the available information the role of vaccine cannot be assessed