Age: 69.0
Sex: M
Vaccine: VARZOS
Symptoms: Corneal scar, Eye inflammation, Herpes zoster, Herpes zoster reactivation, Injury corneal
Clinical narrative: hip neuropathy; irreparable damage to cornea/cornea to explode; re-activation of dormant shingles virus causing rash; rash on left hip; he has severe nerve pain; inflammation in the eye; This serious case was reported by a consumer via call center representative and described the occurrence of neuropathy in a 69-year-old male patient who received Herpes zoster (Shingrix) for prophylaxis.   The patient's past medical history included shingles (shingles outbreak affecting the head and right eye) and corneal scar. Concurrent medical conditions included diabetes. Concomitant products included valaciclovir hydrochloride (Valtrex), tetryzoline hydrochloride (Eye Drops) and cortisone.   On 25-MAR-2024, the patient received the 1st dose of Shingrix. On an unknown date, an unknown time after receiving Shingrix, the patient experienced neuropathy (Verbatim: hip neuropathy) (serious criteria GSK medically significant), injury corneal (Verbatim: irreparable damage to cornea/cornea to explode), shingles (Verbatim: re-activation of dormant shingles virus causing rash), rash (Verbatim: rash on left hip), post herpetic neuralgia (Verbatim: he has severe nerve pain) and eye inflammation (Verbatim: inflammation in the eye). The outcome of the neuropathy, injury corneal, shingles and rash were not resolved and the outcome of the post herpetic neuralgia and eye inflammation were not reported.   The reporter considered the neuropathy, injury corneal, shingles and rash to be related to Shingrix. It was unknown if the reporter considered the post herpetic neuralgia and eye inflammation to be related to Shingrix.     The company considered the neuropathy to be unrelated to Shingrix. The company considered the injury corneal, shingles and rash to be related to Shingrix. It was unknown if the company considered the post herpetic neuralgia and eye inflammation to be related to Shingrix.   Additional Information: GSK Receipt date: 11-JUL-2024 The reporter was the wife of patient. The patient did not come on the phone but he was in the background, he received Shingrix shot 1 on 25 March 2024.  The reporter stated that the Shingrix, had re-activated an old case of shingles that he had in 2005.  He was in very bad shape, he had extreme neuropathy on his left hip.  They have pictures of the shingles rash as well as initially when he had the shingles it presented itself in his head and into the right eye and so it had been dormant all these years. What happened was he had been taking Valtrex and drops because the cornea was scarred.  So, now what happened was when the shingles re-activated whatever virus was still there, it caused the cornea to explode and now he needs a cornea transplant. The reporter stated that she wish we were aware that there was a possibility that it could re-activate the dormant virus, which seem to be exactly what had happened here.  The reporter indicated that her husband's doctor believes that the Shingrix caused a re-activation of the dormant shingles virus.  He had been on the Valtrex drops and things like that in order to keep the old shingles' under control and this immunization just pushed it over the edge.  It caused the rash on left hip which he had severe nerve pain for which we didn't even know what it was before the rash appeared and then what happened was it caused inflammation in the eye which caused the cornea to completely break down.  She didn't know that the virus had been reactivated until the rash came and so what we were doing is he was going to a pain management place for cortisone shots in the hip thinking that it was sciatica pain or whatever it was and it turns out that it was none of that it was a re-activation of the virus and the cortisone shots exacerbated the diabetes that he have.; Sender's Comments: Neuropathy peripheral is an unlisted event which is considered unrelated to GSK vaccine Shingrix.