Sex: U
Vaccine: COVID19, COVID19, COVID19
Symptoms: Abdominal pain, Blood fibrinogen decreased, Blood lactic acid, Disseminated intravascular coagulation, Fibrin D dimer
Clinical narrative: SUPERIOR MESENTERIC ARTERY THROMBOSIS; SMALL BOWEL OBSTRUCTION; DISSEMINATED INTRAVASCULAR COAGULATION; SMALL BOWEL NECROSIS; GANGRENE OF THE INTESTINE; ABDOMINAL PAIN; CYTOPENIA; This spontaneous report received from a physician and concerned a patient of unspecified age and sex. The patient's height, and weight were not reported. The patient's concurrent conditions included morbid obesity, alcohol use, and non-smoker, and no drug abuse or illicit drug use. The patient has no history of abdominal surgery and no known allergies. The patient received covid-19 vaccine (suspension for injection, intramuscular, batch number: Unknown) dose was not reported, administered approximately on 14-MAR-2021 for prophylactic vaccination. No concomitant medications were reported.  On 20-MAR-2021, the patient was admitted to the hospital with abdominal pain. On 20-MAR-2021, the patient developed superior mesenteric artery thrombosis. On 20-MAR-2021, a CT scan was done and showed: small bowel obstruction, disseminated intravascular coagulation, superior mesenteric artery thrombosis, small bowel necrosis, gangrene of the intestine, which was surgically removed via bowel resection. The patient developed cytopenia on unspecified date in MAR-2021. As per treating physician, patient was given platelet transfusion. Patient underwent emergency laparoscopy with resection of small bowel. As per treating physician, the patient recovered in Intensive care Unit (ICU) and now transferred back to the floor. The action taken with covid-19 vaccine was not applicable. The patient was recovering from small bowel necrosis and disseminated intravascular coagulation, and the outcome of abdominal pain, small bowel obstruction, superior mesenteric artery thrombosis, gangrene of the intestine and cytopenia was not reported. This report was serious (Hospitalization Caused / Prolonged, and Other Medically Important Condition).; Sender's Comments: V0: This spontaneous report received from a physician, concerns a patient of unspecified age and sex who was hospitalized for superior mesenteric artery thrombosis, small bowel obstruction, disseminated intravascular coagulation, small bowel necrosis, cytopenia and abdominal pain, 6 days after Janssen COVID-19 vaccine, was administered for prevention of COVID-19 infection. The patient's concurrent conditions included morbid obesity and alcohol use.  No history of smoking, or illicit drug use. No history of prior abdominal surgery and no known allergies. Upon admission, the CT scan showed "small bowel obstruction, disseminated intravascular coagulation, superior mesenteric artery thrombosis, small bowel necrosis, gangrene of the intestine". The patient also developed "cytopenia" and was given platelet transfusion. The patient underwent an emergency laparoscopy with resection of small bowel and is recovering from the small bowel necrosis and disseminated intravascular coagulation. Outcome of other events has not been reported.  Although there is a close temporal relationship there is insufficient information, and the events are assessed to have an indeterminate causal association to immunization, per the  causality classification for adverse events following immunization .Company causality is considered not related to Janssen vaccine, while additional information has been requested for further assessment (e.g.  age, sex, risk factors, concomitant medications, vaccination date, diagnostic test results including platelet count, coagulation profile, anti PF4 factor, COVID-19 test).