Age: 58.0
Sex: F
Vaccine: VARZOS
Symptoms: Arthralgia, Condition aggravated, Dizziness, Dyspnoea, Erythema
Clinical narrative: feeling dizzy; feeling flushed; feeling headache; feeling red; breathing was affected; Premature Ventricular Contractions; pre-existing nerve pain due to a prior surgery; Horrible nerve pain; Trouble sleeping; hip pain; hands pain/feet pain; pain like this affecting so many different parts of her body; felt like her back has a sunburn; This non-serious case was reported by a consumer via call center representative and described the occurrence of premature ventricular contractions in a 58-year-old female patient who received Herpes zoster (Shingrix) for prophylaxis.   The patient's past medical history included nerve pain and stenosis (Patient had severe cervical stenosis sacrum lumbar (L13, L14)). Previously administered products included Shingrix (received first shot of Shingrix in AUG 2023). Concurrent medical conditions included edema, fall, premature ventricular contractions (Patient had PVCs (Premature Ventricular Contractions) on and off), work problem (since Feb 2023 patient was not been able to work (disability) due to not being able to sit or stand or walk for long periods of time) and walking disability (since Feb 2023 patient was not been able to work (disability) due to not being able to sit or stand or walk for long periods of time). Family history included shingles (Patients family members had shingles in the past) and surgery.   On 12-DEC-2023, the patient received the 2nd dose of Shingrix. In DEC-2023, less than a day after receiving Shingrix, the patient experienced premature ventricular contractions (Verbatim: Premature Ventricular Contractions), condition aggravated (Verbatim: pre-existing nerve pain due to a prior surgery), nerve pain (Verbatim: Horrible nerve pain), dizziness (Verbatim: feeling dizzy), flushing (Verbatim: feeling flushed), headache (Verbatim: feeling headache), erythema (Verbatim: feeling red), difficulty breathing (Verbatim: breathing was affected), difficulty sleeping (Verbatim: Trouble sleeping), pain in hip (Verbatim: hip pain), pain in hand (Verbatim: hands pain/feet pain), general body pain (Verbatim: pain like this affecting so many different parts of her body) and sunburn (Verbatim: felt like her back has a sunburn). The patient was treated with gabapentin and tramadol hydrochloride (Tramadol). In DEC-2023, the outcome of the premature ventricular contractions, condition aggravated, dizziness, flushing, headache, erythema and difficulty breathing were resolved. The outcome of the nerve pain, pain in hip, pain in hand and general body pain were not resolved and the outcome of the difficulty sleeping and sunburn were not reported.   The reporter considered the premature ventricular contractions, condition aggravated, nerve pain, dizziness, flushing, headache and erythema to be related to Shingrix. It was unknown if the reporter considered the difficulty breathing, difficulty sleeping, pain in hip, pain in hand, general body pain and sunburn to be related to Shingrix.     The company considered the premature ventricular contractions, condition aggravated, nerve pain, dizziness, flushing, headache and erythema to be related to Shingrix. It was unknown if the company considered the difficulty breathing, difficulty sleeping, pain in hip, pain in hand, general body pain and sunburn to be related to Shingrix.   Additional Information: GSK Receipt Date: 12-DEC-2023 The patient contacted GSK via web form. The Drug dosage was reported as 50 nci. The patient reported she had a horrible nerve pain. The patient had preexisting nerve pain which was due surgery and fall. She usually did not have like this pain affecting so many different parts of her body (hands, feet, hip etc.). All the pain was at all one time. Last night she had trouble sleeping due to pain. She had to keep switching sides to the hip pain. She said it felt like every nerve ending she has was firing at the same time. Her husband was rubbing her back and it felt like her back has a sunburn. She took tramadol, gabapentin and an unspecified anti-inflammatory but she was still in pain and was getting worse. She also reported feeling dizzy, flushed, red, headache and that her breathing was affected but these events resolved. She also reported that in the past she has had PVCs (Premature Ventricular Contractions) on and off but since getting Shingrix 2nd shot she has had 7 or 8 PVCs and had to go lay down. The patient was unable to locate the lot number of the shot she received but did provide her pharmacy's contact information. The reporter consented to follow up.