Age: 51.0
Sex: F
Vaccine: VARZOS
Symptoms: Arthralgia, Asthenia, Burning sensation, Fatigue, Feeling abnormal
Clinical narrative: Possible shingles / breaking out again with shingles; Pain at Injection Site; Spot on Arm /grapefruit-sized spot appeared on arm where vaccine was administered; Joint Pain in Feet / joint pain in both feet; Flu-like Symptoms; Spot around right breast / Stomach Rash tiny bumps; burning of bumps; feeling dehydrated; having no energy; extreme exhaustion /feeling drained; This case was reported by a consumer via call center representative and described the occurrence of shingles in a 51-year-old female patient who received Herpes zoster (Shingrix) for prophylaxis.   The patient's past medical history included shingles (her first outbreak of shingles was under her left breast near breast bone).   In October 2019, the patient received the 1st dose of Shingrix (intramuscular). In October 2019, less than 3 weeks after receiving Shingrix, the patient experienced shingles, injection site pain, injection site rash, pain in joint involving lower leg, influenza-like symptoms, rash, burning sensation, feeling abnormal, loss of energy and exhaustion. On an unknown date, the outcome of the shingles, injection site pain, injection site rash, pain in joint involving lower leg, feeling abnormal, loss of energy and exhaustion were unknown and the outcome of the influenza-like symptoms was recovered/resolved and the outcome of the rash and burning sensation were not recovered/not resolved.   It was unknown if the reporter considered the shingles, injection site pain, injection site rash, pain in joint involving lower leg, influenza-like symptoms, rash, burning sensation, feeling abnormal, loss of energy and exhaustion to be related to Shingrix.  Additional case details were reported as follows: The patient received 1st dose Shingrix approximately 2 weeks ago in her left arm and that the injection was painful. Approximately 2 days later, caller reports grapefruit-sized spot appeared on arm where vaccine was administered. Also, joint pain in both feet and then flu-like symptoms began. After probing, reporter described flu-like symptoms as feeling drained, having no energy, extreme exhaustion similar to feeling dehydrated. The reporter reported flu-like symptoms would resolve in 2 days, but on the 3rd day it would start again.  Approximately 1.5 weeks following vaccination patient noticed a spot on her right breast followed by a second below breast the next day.  The reporter reported currently no flu-like symptoms the last 2 days, but over these last 2 days she developed a stomach rash described as tiny bumps.  The bumps do not burn like the initial bump and that the initial bump, the bump that lasted the longest was now burning.  The patient was breaking out again with shingles due to similar burning that got worse over time. The reporter reported that her current rash was not coming back in spot she initially had shingles. The reporter described her first shingles rash as starting out by what appeared to be a bug bite, but it did not get better as days went on.  The reporter mentioned shingles got worse as the days went on. The reporter consent to follow up.