Age: 66.0
Sex: M
Vaccine: PNC20
Symptoms: Immunisation reaction, Immunoglobulin therapy, Life support, Loss of personal independence in daily activities, Magnetic resonance imaging head abnormal
Clinical narrative: ADEM/lost 2 weeks of memory/could not drink, he could not walk, he could not talk; brain still has lesions in it; neuropathy in his feet; legs are weak; head still swims and he gets very dizzy; skin on his chest and back when his shirt material touches his skin it burns; This is a spontaneous report received from a Consumer or other non HCP.   A 66-year-old male patient received pneumococcal 20-val conj vac (dipht CRM197 protein) (PREVNAR 20), on 13Sep2023 as dose number unknown, single (Batch/Lot number: unknown) at the age of 66 years, in left arm for immunisation. The patient had no relevant medical history. There were no concomitant medications. The following information was reported: ACUTE DISSEMINATED ENCEPHALOMYELITIS (hospitalization, life threatening) with onset 22Sep2023, outcome "recovering", described as "ADEM/lost 2 weeks of memory/could not drink, he could not walk, he could not talk"; CENTRAL NERVOUS SYSTEM LESION (medically significant), outcome "unknown", described as "brain still has lesions in it"; NEUROPATHY PERIPHERAL (medically significant), outcome "not recovered", described as "neuropathy in his feet"; MUSCULAR WEAKNESS (non-serious), outcome "recovering", described as "legs are weak"; DIZZINESS (non-serious), outcome "not recovered", described as "head still swims and he gets very dizzy"; SKIN BURNING SENSATION (non-serious), outcome "recovering", described as "skin on his chest and back when his shirt material touches his skin it burns". The patient was hospitalized for acute disseminated encephalomyelitis (start date: 22Sep2023, discharge date: 12Oct2023, hospitalization duration: 21 day(s)). The event "adem/lost 2 weeks of memory/could not drink, he could not walk, he could not talk" required physician office visit and emergency room visit. The patient underwent the following laboratory tests and procedures: Magnetic resonance imaging: brain still has lesions in it. Therapeutic measures were taken as a result of acute disseminated encephalomyelitis. Additional information: Caller is a consumer that was calling about the Prevnar 20. He had the vaccine on 19Sep2023 and came down with ADEM 9 days later. It is not good. He was in the hospital for 21 days and on life support for 3 days and his neurologist and other physicians confirmed that it was from the Prevnar 20 that he had received 9 days prior to that. He currently has some residual issues and wanted to report this. He is currently going through the national vaccine program and has other concerns that he is not going to go into now.  He used to play golf everyday and now he is lucky if he can play once a week and stated that his legs are weak. His head still swims and he gets very dizzy. His skin on his chest and back when his shirt material touches his skin it burns. He also reported that he has neuropathy in his feet. It has been a big ordeal. ADEM event details: On the morning of 22Sep2023 his words were starting to slur together and they thought he had a stroke.  His wife wanted to take him to the hospital and at that point he lost 2 weeks of memory and stated that he knows only what they told him. He said that it hit him quick. They took him to the first hospital and checked him for a stroke and confirmed that he did not have a stroke. They did not know what was wrong with him and so they put him in a ambulance and he was sent to another hospital 45 minutes away. When he got there they did not know what was wrong either. His wife told the doctor that he had just had the Prevnar 20 and the neurologist said ah-ha and they started treating him for that and gave him a bunch of medications, put him on life support, and they did not know if he was going to live or not. He could not drink, he could not walk, he could not talk, but he could eat. He was in the hospital for 2 weeks and then was discharged, but was still having a bunch of problems and so he went back to the hospital and they admitted him for another week and administered him IVIG for like 3 or 4 days for the ADEM and then he was discharged. He is still recovering and is better, but does not know if he will ever get back to normal. Legs weak: he was bedridden in the hospital. He does not know exactly when his legs being weak started and said that he was not able to get out of bed or the alarm would go off when in the hospital. He did not start walking until the end of Oct2023. The leg weakness may have gotten a little better, but his legs are still pretty weak. Skin on his chest and back when his shirt material touches his skin it burns: Skin may have gotten a little better, but it is still pretty bad and doctors said that it is all nerve related. ADEM is a demyelination of the nerves. The nerves are coated like a wire and that covering comes off and when your nerves touch each other everything screws up. Neuropathy in his feet: He had the neuropathy in his feet in the hospital and it is the same. History: He goes to the hospital once a year for a physical and was perfectly healthy up until this.Testing: He still has MRI's and stated that he is still going for MRI's because his brain still has lesions in it.  The information on the batch/lot number for pneumococcal 20-val conj vac (dipht CRM197 protein) will be requested and submitted if and when received.