Sex: U
Vaccine: PPV
Symptoms: Injection site erythema, Injection site pruritus
Clinical narrative: hard reaction; The area where the injection is started to get red and itchy; The area where the injection is started to get red and itchy; This spontaneous report was received from a consumer (patient) of unknown age and gender. Information on the patient's medical history, concurrent conditions and concomitant medications were not reported. The patient past drug included an unspecified pneumococcal vaccine, polyvalent (23-valent (manufacturer unknown) administered 3 or 4 years ago. The patient's concurrent conditions included sinus congestion.  Approximately on 12-FEB-2020 (also reported as 13 days ago) the patient was vaccinated with pneumococcal vaccine, polyvalent (23-valent (manufacturer unknown) (strength, dose, frequency, route, lot # and expiration date were not provided) for prophylaxis. Approximately on 25-FEB-2020 (also reported as "this morning"), the patient reported that the injection site started to get red and itchy (injection site pruritus and injection site erythema). The patient called the pharmacy and was told that the reaction was not normal as the reaction to vaccine usually occurred within 72 hours (also reported as 2 or 3 days) and advised to take diphenhydramine hydrochloride (BENADRYL). It was reported that the itching disappeared and the redness decreased. On the same day, at 1:00 PM, after the patient reached home, the patient developed itching again and injection site appeared pink. The patient took another dose of diphenhydramine hydrochloride (BENADRYL). On an unknown date, the patient started therapy with lisinopril (manufacturer unknown) (strength, dose, frequency, route, lot #, expiration date were not provided) for an unknown indication. On an unknown date, the patient had a very hard reaction (adverse event NOS) to lisinopril (manufacturer unknown). On an unknown date, the patient had to go to the hospital for the same. The patient was reportedly taking fluticasone and azelastine hydrochloride nasal spray for sinus congestion along with an unspecified blood pressure medication. The patient was afraid if the drugs were contraindicated with pneumococcal vaccine, polyvalent (23-valent (manufacturer unknown). The patient was also afraid if the reaction could be an anaphylactic reaction.  The action taken with the suspect therapy of lisinopril (manufacturer unknown) was unknown. The outcome of the events was unknown.  The causal relationship between the adverse event and the suspect therapy of pneumococcal vaccine, polyvalent (23-valent (manufacturer unknown) was considered to be not related and the causal relationship between the events of injection site pruritus, injection site erythema and the suspect therapy of pneumococcal vaccine, polyvalent (23-valent (manufacturer unknown) was not provided. The causal relationship between the events of injection site pruritus, injection site erythema and the suspect therapy of lisinopril (manufacturer unknown) was considered to be not related and the causality assessment between the adverse event and the suspect therapy of lisinopril (manufacturer unknown) was not provided.