Age: 26.0
Sex: F
Vaccine: FLU4, FLU4, FLU4
Symptoms: Urticaria
Clinical narrative: hyperventilating; tingling in both legs; numbness in both legs; cold sensation; high blood pressure; muscle twitches in both legs; swelling under her eyes; hives on her right and left jaw line, the right side of her neck and on her chest.; her right leg had decreased reflexes and and she couldn't feel the difference between sharp and dull reflexes.; Initial information received on 26-Nov-2019 regarding an unsolicited valid serious case received from a consumer/non-health care professional.  This case involves a 26 years old female patient who received vaccine INFLUENZA QUADRIVAL A-B VACCINE [FLUZONE QUADRIVALENT] and experienced hives on her right and left jaw line, the right side of her neck and on her chest (urticaria), hyperventilating (hyperventilation), tingling in both legs (paraesthesia), numbness in both legs (hypoaesthesia) cold sensation (feeling cold), swelling under her eyes (eye swelling), high blood pressure (blood pressure increased), muscle twitches in both legs (muscle twitching) and her right leg had decreased reflexes and she couldn't feel the difference between sharp and dull reflexes (Hyporeflexia).  The patient's past medical history, medical treatment(s), vaccination(s), concomitant medication(s) and family history were not provided.  On 18-Nov-2019, the patient received a dose of suspect INFLUENZA QUADRIVAL A-B VACCINE Prefilled Syringe lot UJ279AC, exp date: Oct 2020 via unknown route in the left arm.  On 18-Nov-2019, the patient developed a serious hives on her right and left jaw line, the right side of her neck and on her chest. (urticaria) following the administration of INFLUENZA QUADRIVAL A-B VACCINE. All events was assessed as medically significant.  On 19-Nov-2019,the patient developed a serious hyperventilating (hyperventilation), tingling in both legs (paraesthesia), numbness in both legs (hypoaesthesia) cold sensation (feeling cold), swelling under her eyes (eye swelling), high blood pressure (blood pressure increased), muscle twitches in both legs (muscle twitching) and her right leg had decreased reflexes and she couldn't feel the difference between sharp and dull reflexes (Hyporeflexia) 1 day following the administration of INFLUENZA QUADRIVAL A-B VACCINE. All events was assessed as medically significant.  Relevant laboratory test results included:  Blood pressure measurement - On an unknown date: 150/80  Inflammation - On an unknown date: [normal]  Primitive reflex test - On an unknown date: [normal]  Protein total - On an unknown date: [normal]  Final diagnosis was hyperventilation, feeling cold, blood pressure increased, twitches, eye swelling, Hyporeflexia and hives.  The patient was treated with DIPHENHYDRAMINE HYDROCHLORIDE (BENADRYL ALLERGY [DIPHENHYDRAMINE HYDROCHLORIDE]).  At the time of reporting, the patient outcome was reported as Unknown for all the events.; Sender's Comments: This case involves a 26 years female patient presented with  hyperventilation, feeling cold, blood pressure increased, twitches, eye swelling, Hyporeflexia  and hives after vaccination (hypersensitivity reaction) with FLUZONE QUADRIVALENT. Time to onset is compatible with the role of vaccine. There is, however, no information regarding patient's medical condition at time of vaccination, identification of the causative factor, safety of the vaccination procedure and lab tests ruling out alternate etiologies. Based upon the reported information, the role of the vaccine cannot be assessed.