Age: 70.0
Sex: F
Vaccine: VARZOS
Symptoms: Erythema, Flushing, Injection site erythema, Injection site pruritus, Injection site urticaria
Clinical narrative: erythema left arm at injection site; some hives left arm at injection site; some itchiness left arm at injection site; puffiness of the skin; puffiness it is also migrating up her shoulder to neck and her face; puffiness of the skin and it is also migrating up her shoulder; puffiness of the skin and it is also migrating up her shoulder to neck; Her face is flushed; face is erythematous; her face is shiny; This non-serious case was reported by a nurse via call center representative and described the occurrence of injection site erythema in a 70-year-old female patient who received Herpes zoster (Shingrix) for prophylaxis.   Concurrent medical conditions included drug allergy (allergy of anticholinergics).   In MAY-2024, the patient received Shingrix (left arm). On 23-MAY-2024, less than a week after receiving Shingrix, the patient experienced injection site erythema (Verbatim: erythema left arm at injection site), injection site hives (Verbatim: some hives left arm at injection site), injection site itching (Verbatim: some itchiness left arm at injection site), puffy skin (Verbatim: puffiness of the skin), facial puffiness (Verbatim: puffiness it is also migrating up her shoulder to neck and her face), swollen joints (Verbatim: puffiness of the skin and it is also migrating up her shoulder), neck swelling (Verbatim: puffiness of the skin and it is also migrating up her shoulder to neck), facial flushing (Verbatim: Her face is flushed), red face (Verbatim: face is erythematous) and skin disorder (Verbatim: her face is shiny). The outcome of the injection site erythema, injection site hives, injection site itching, puffy skin, facial puffiness, swollen joints, neck swelling, facial flushing, red face and skin disorder were not resolved.   It was unknown if the reporter considered the injection site erythema, injection site hives, injection site itching, puffy skin, facial puffiness, swollen joints, neck swelling, facial flushing, red face and skin disorder to be related to Shingrix.     It was unknown if the company considered the injection site erythema, injection site hives, injection site itching, puffy skin, facial puffiness, swollen joints, neck swelling, facial flushing, red face and skin disorder to be related to Shingrix.   Additional Information: GSK Receipt Date: 24-MAY-2024 The patient was administered with Shingrix on 22-MAY-2024 or 23-MAY-2024, exact date unknown by registered nurse as it was done at pharmacy. At the site of injection patient was having some erythema, some hives, some itchiness, a little bit of puffiness of the skin and it was also migrating up her shoulder to neck and her face. The patient had little bit of puffiness of the skin (Healthcare professional (HCP) did not identify if it was at injection site). The patient's face was very flushed, erythematous, shiny and reporter want to know if there was anything specifically in the vaccine that could be causing such an adverse effect or what GSK might recommend. The patient travelled out of country and did not receive emergency treatment. Status: continues with same symptoms on the day of reporting, when asked if it was getting worse, the HCP said, he/she believed so. When asked what the physician was telling patient to do, so far, they were waiting on GSK to tell them what specifically was in the vaccine that could be causing this so that they could treat that specific compound that's causing it, that's why reporter called to make sure what in the vaccine could be causing such a reaction. This case had been link with US2024064939, reported by the same reporter.; Sender's Comments:  US-GSK-US2024064939:Same reporter