Age: 0.6
Sex: F
Vaccine: HBHEPB, PNC, HBHEPB, PNC
Symptoms: Hearing impaired, Meningitis, Platelet count increased, Sepsis
Clinical narrative: A nurse reported that a 7 month old female received her 3rd dose of Prevnar and 2nd dose of Comvax on 03/27/01. On 05/05/01, she developed meningitis and bacteremia. She was admitted to the hospital. The reporter indicated that she reported this event to Communicable Disease, Reportable Diseases in Kansas. A copy of this report has been forwarded to Merck, manufacturer of Comvax. Follow-up received from the nurse on 06/06/01 indicated that the infant recovered from the meningitis; however, the mother of the infant states that her daughter has significant hearing loss in her right ear. F/U states that information was received from a nurse concerning a 9 month old female who on 3/27/01 was vaccinated IM in the left leg with a 2nd dose of Hib vaccine (lot 637874/1524K). Concomitant therapy included a 3rd dose IM in the right leg of Prevnar (474726). There was no illness at the time of the vaccination. On 5/5/01, the pt developed meningitis and bacteremia and was hospitalized. It was reported that a blood culture was done and was (+). It was noted that on 11/22/00 and 1/16/00, the pt received a 1st dose IM in the right leg (lot 473342) and a 2nd dose IM in the left leg (lot 473450) respectively of Prevnar. It was also noted that on 11/22/01, the pt received a 2nd dose Im in the right leg of Hib-Titer (lot 560903A). Follow-up information has been received from a health care professional who reports the pt had residual hearing loss, but she could not report on which ear or any other details. Additional info has been requested. Additional F/U has been received from a healthcare professional who reports there was profound hearing loss on the right side. Additional information has been requested. Follow-up received from the nurse on 06/06/2001 indicated that the infant recovered from the meningitis; however, the mother of the infant states that her daughter has significant hearing loss in her right ear. Follow-up info was received from the infant's primary care physician on 01/29/2002. The physician indicated that the infant was seen in the office on 05/11/2001 for follow-up to the hospitalization for pneumococcal meningitis and streptococcal septicemia. The infant was noted to have "profound deafness" in her right ear. Laboratory results from blood collected on 05/11/2001 revealed no growth at day 7 and a platelet count increased. A neurologic exam revealed no meningeal sings. Treatment included continuation of intravenous cefotaxime and acetaminophen. The pt was to be see by county health dept in September 2001 for a hearing test but did not show up for scheduled appointment. The physician reported that the family had not been compliant with his recommendations. As of 01/29/2002, he was unaware of the pt's location and believes that the family has moved away. Reported on 02/04/2003: A nurse from the public health clinic reported on 01-22-2003 that the child recovered but is deaf in the right ear and her left leg lags when she tries to run.  According to the nurse, the mother stated that "the child's father and child are both carriers of Streptococcal meningitis."  A copy of this report has been forwarded to Merck, manufacturer of Comvax.