Age: 28.0
Sex: F
Vaccine: COVID19
Symptoms: Blister, Lip swelling, Pruritus, Rash, Urticaria
Clinical narrative: Bumps and the upper lip was very lightly puffy; blisters showed up on the upper inner arms around the biceps; Itchiness; Spontaneous and acute urticaria or hives; Rash; This spontaneous case was reported by a consumer and describes the occurrence of URTICARIA (Spontaneous and acute urticaria or hives), RASH (Rash), PRURITUS (Itchiness), BLISTER (blisters showed up on the upper inner arms around the biceps) and LIP SWELLING (Bumps and the upper lip was very lightly puffy) in a 29-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 012H21B, 045B21A and 039A21A) for COVID-19 vaccination.     No Medical History information was reported.   On 03-Apr-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 01-May-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 11-Dec-2021, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 18-Dec-2021, the patient experienced URTICARIA (Spontaneous and acute urticaria or hives) and RASH (Rash). On 19-Dec-2021, the patient experienced PRURITUS (Itchiness). On 20-Dec-2021, the patient experienced BLISTER (blisters showed up on the upper inner arms around the biceps). On 21-Dec-2021, the patient experienced LIP SWELLING (Bumps and the upper lip was very lightly puffy). The patient was treated with PREDNISONE at a dose of 10 milligram; CETIRIZINE HYDROCHLORIDE (ZYRTEC [CETIRIZINE HYDROCHLORIDE]) at a dose of every 4 hours; DIPHENHYDRAMINE HYDROCHLORIDE (BENADRYL [DIPHENHYDRAMINE HYDROCHLORIDE]) at a dose of every 4 hours; METHYLPREDNISOLONE SODIUM SUCCINATE (SOLUMEDROL) (intravenous) at an unspecified dose and frequency and FAMOTIDINE (PEPCID [FAMOTIDINE]) at an unspecified dose and frequency. At the time of the report, URTICARIA (Spontaneous and acute urticaria or hives), RASH (Rash), PRURITUS (Itchiness), BLISTER (blisters showed up on the upper inner arms around the biceps) and LIP SWELLING (Bumps and the upper lip was very lightly puffy) had not resolved.            Patient's adverse events were what seems to be spontaneous and acute urticaria or hives and rash consisting of red blotches, red streaks and red lines, and they are really all over. It started as a few small red hives on the back; they were sparse. At 9 to 9:30 pm 18-Dec-2021, the hives spread to chest, below the neckline and shoulders, and they were apparent on lower back. On 19-Dec-2021, few dime-sized red blotches appeared on upper chest. On 20-Dec-2021, there were more hives, more small red blotches; hives developed on both arms, down to her wrists and hands. At around 12 pm 20-Dec-2021, she developed red streaks and red lines on the stomach as well. A couple hours later, everything started getting worse rapidly: blisters showed up on the upper inner arms around the biceps. The hives started to worsen; very large red rash appeared on upper back and neck leading up to her scalp with big red long lines. There were more big red lines appearing on the stomach; larger red lines going down her abdomen and hips, wrapping around the waist on both sides. There were red rashes on her wrist, shoulders and chest; and lower back was still covered in hives and rash. On 20-Dec-2021, they decided to go to the emergency room. That was when they had spread to the legs.  Nothing was improving. She has been taking the prednisone, Zyrtec and Benadryl, but symptoms were not improving. This rash was very weird. It was around the lower back for 6 to 8 hours, then it disappears and comes back on different parts; they were not consistent. It was difficult to say where exactly it was at. It just goes in and out. Lastly, starting 3 pm until now (9 pm 21-Dec-2021) it moved to her mouth; to the inner part of the upper lip. Since about 8 pm, the ones on the upper lip had gone away, but it moved to the lower lip now, and the lower lip was puffy and red, but not swollen significantly.   No concomitant medication was reported.