Age: 73.0
Sex: F
Vaccine: COVID19
Symptoms: Echocardiogram, Electrocardiogram ST segment, Imaging procedure, Stress cardiomyopathy, Troponin
Clinical narrative: Takotsubo syndrome; This literature-non-study case was reported in a literature article and describes the occurrence of STRESS CARDIOMYOPATHY (Takotsubo syndrome) in a 73-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination.   LITERATURE REFERENCE:    Concurrent medical conditions included Myocardial infarction with nonobstructive coronary arteries (recently diagnosed).    On an unknown date, the patient received dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On an unknown date,  after starting mRNA-1273 (Moderna COVID-19 Vaccine), the patient experienced STRESS CARDIOMYOPATHY (Takotsubo syndrome) (seriousness criteria hospitalization and medically significant). At the time of the report, STRESS CARDIOMYOPATHY (Takotsubo syndrome) outcome was unknown.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On an unknown date, Echocardiogram: takotsubo syndrome Consistent with mid-ventricular Takotsubo syndrome (TTS). On an unknown date, Electrocardiogram ST segment: abnormal (abnormal) abnormal. On an unknown date, Imaging procedure: normal (normal) showed improvement in systolic function prior to discharge.. On an unknown date, Troponin: elevated (High) Elevated.     The action taken with mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown) was unknown.   For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown), the reporter considered STRESS CARDIOMYOPATHY (Takotsubo syndrome) to be possibly related.    Treatment for event included diuretics, betablockers, and angiotensin receptor blockers.  Patient is a postmenopausal woman with a recent diagnosis of MINOCA who developed TTS shortly after receiving the COVID-19 vaccine. Risk factors included sex, age, MINOCA, anxiety about the vaccine, and possibly the vaccine itself may have all contributed to the TTS presentation.  Concomitant product use was not provided by the reporter.  Company Comment :This case concerns a 73 year-old, female patient with a history of Acute myocardial infarction, who experienced the serious (due to hospitalization) unexpected AESI of Stress cardiomyopathy. The event occurred shortly after the mRNA-1273 vaccine, dose number not provided. The rechallenge was not applicable since dose number was not provided. The medical history, of Acute myocardial infarction, patient´s advanced age and gender remain as confounders. The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report.; Sender's Comments: This case concerns a 73 year-old, female patient with a history of Acute myocardial infarction, who experienced the serious (due to hospitalization) unexpected AESI of Stress cardiomyopathy. The event occurred shortly after the mRNA-1273 vaccine, dose number not provided. The rechallenge was not applicable since dose number was not provided. The medical history, of Acute myocardial infarction, patient´s advanced age and gender remain as confounders. The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report.