Sex: F
Vaccine: PNC13
Symptoms: Antibody test negative, Infection, Malaise, Sinusitis, Streptococcal infection
Clinical narrative: This is a spontaneous report from a contactable consumer (patient's mother). This mother reported for her 2 daughters. This is the 2nd case (younger daughter) out of the 2 cases. A female patient of an unspecified age (going to be 2) and ethnicity received PREVNAR 13 (Lot # not available) via an unspecified route of administration at single on an unspecified date for immunization, following the CDC schedule for vaccination. The patient medical history and concomitant medications were not reported. On an unspecified date the patient experienced persistent sinus infections with outcome of not recovered, strep 2 infection with outcome of unknown, they were vaccinated but yet she was not having immunity with outcome of unknown, persistent problems with illness with outcome of not recovered. Therapeutic measures were taken as a result of persistent sinus infections, strep 2 infection. Course of events: After the vaccinations, the child was fine but fast forward a year or so later she was having persistent problems with illness with recurrent infections. Heavy growth strep was diagnosed at the end of Nov2016. Nasal swab test turned out that it was a Strep in the category of 2 which was puzzling to the paediatrician because she had been vaccinated for the strains that are covered in that type 2 category. The Pneumo titers were done and has immunity for 4 out of the 13 and actually that was not true, it was 4 out of the 23. [not reported clearly that out of the two children which child has immunity of 1 out of 13 and which child has immunity of 4 out of 2]. So the mother did not know if it was the 13 or if there was some that were outside of that has been vaccinated, she did not know but next one will be 4th. There was improvement for her and her younger sister for a few days while she was taking an antibiotic and then they had infections again. A pneumonia titer was done 22Dec2016 and it came back that the older child did not have immunity to any of the 13; she only had immunity to 19F. For the rest of the serotypes, the immunity was all under 2. Nasal Swab Test (Date unspecified): Strep type 2 infection. The family actually had different paediatrician during that time because they moved from one state to another but they were right on time with vaccinations, like within a day of the next eligible time period and the mother was calling about PREVNAR 13. The mother called since she was not sure but the children were vaccinated but then they found that they are having some repeated continual sinus infection problems. Her younger sibling has persistent sinus infections and there is the same situation with the younger sibling as with the oldest daughter. The mother concern was the fact the child was vaccinated but yet she was not having immunity towards she was vaccinated for and as a result have become quite ill. There is  a very resistant form of Strep and so the mother was wondering what was the percentage of efficacy when you go through the CDC recommended schedule of the 2 month, 4 month, 6 month and then between 12 and 15 month schedule. A Product Complaint was filed.