Age: 66.0
Sex: F
Vaccine: COVID19
Symptoms: Rash, Swelling face, Urticaria
Clinical narrative: Forehead is totally swollen and it hurts; woke up with a swollen bottom lip/lip swelling got worse on Monday and the patient went to see her Physician.; swelling above her right eye/left eye is swollen and almost shut.; patient has an asthma cough; swelling on both wrists/Swelling was so bad the patient could not bend her wrists/Patients wrists continued to swell.; Hives on both wrists/broke out in hives/hives on her wrists/welts on her waist which are getting better/My face and neck have hives; Rash under both of her arms; Sore arm; This spontaneous case was reported by a patient and describes the occurrence of JOINT SWELLING (swelling on both wrists/Swelling was so bad the patient could not bend her wrists/Patients wrists continued to swell.), LIP SWELLING (woke up with a swollen bottom lip/lip swelling got worse on Monday and the patient went to see her Physician.), EYE SWELLING (swelling above her right eye/left eye is swollen and almost shut.), COUGH (patient has an asthma cough) and SWELLING FACE (Forehead is totally swollen and it hurts) in a 66-year-old female patient who received mRNA-1273 BIVALENT .222 (MODERNA COVID-19 VACCINE, BIVALENT (ORIGINAL AND OMICRON BA.4/BA.5)) (batch no. AS7144B) for COVID-19 prophylaxis. The occurrence of additional non-serious events is detailed below.     Concurrent medical conditions included Asthma. Concomitant products included FAMOTIDINE, ATORVASTATIN, ESCITALOPRAM and ASPIRIN [ACETYLSALICYLIC ACID] for an unknown indication.    On 14-Sep-2022, the patient received fifth dose of mRNA-1273 BIVALENT .222 (MODERNA COVID-19 VACCINE, BIVALENT (ORIGINAL AND OMICRON BA.4/BA.5)) (unknown route) 1 dosage form. On 15-Sep-2022, the patient experienced PAIN IN EXTREMITY (Sore arm). On 17-Sep-2022, the patient experienced JOINT SWELLING (swelling on both wrists/Swelling was so bad the patient could not bend her wrists/Patients wrists continued to swell.), URTICARIA (Hives on both wrists/broke out in hives/hives on her wrists/welts on her waist which are getting better/My face and neck have hives) and RASH (Rash under both of her arms). On 18-Sep-2022, the patient experienced LIP SWELLING (woke up with a swollen bottom lip/lip swelling got worse on Monday and the patient went to see her Physician.), EYE SWELLING (swelling above her right eye/left eye is swollen and almost shut.) and COUGH (patient has an asthma cough). On 21-Sep-2022, the patient experienced SWELLING FACE (Forehead is totally swollen and it hurts). The patient was treated with PREDNISONE on 17-Sep-2022 at a dose of taper; DIPHENHYDRAMINE HYDROCHLORIDE (BENADRYL [DIPHENHYDRAMINE HYDROCHLORIDE]) at a dose of 25 milligram; FAMOTIDINE (PEPCID [FAMOTIDINE]) at a dose of 20 milligram; HYDROXYZINE at an unspecified dose and frequency and DIPHENHYDRAMINE at a dose of 25 milligram. At the time of the report, JOINT SWELLING (swelling on both wrists/Swelling was so bad the patient could not bend her wrists/Patients wrists continued to swell.), LIP SWELLING (woke up with a swollen bottom lip/lip swelling got worse on Monday and the patient went to see her Physician.), EYE SWELLING (swelling above her right eye/left eye is swollen and almost shut.), COUGH (patient has an asthma cough), SWELLING FACE (Forehead is totally swollen and it hurts), URTICARIA (Hives on both wrists/broke out in hives/hives on her wrists/welts on her waist which are getting better/My face and neck have hives), RASH (Rash under both of her arms) and PAIN IN EXTREMITY (Sore arm) outcome was unknown.            The patient's first primary series Moderna Covid-19 vaccine was on 6-FEB-202. Lot number was 011M20A the patient did not remember which arm that she received the vaccine in. The patient was a little tired.  The patients' second Moderna Covid-19 vaccine was on 28-MAR-2021. Lot number was 003A21A expirarion date was not available. Patient did not remember which arm that she received the vaccine. The patient got tired and had a sore throat. Slept for a while.  The patient's first booster dose was 22-OCT-2021. Lot number was 026D21A expiration date was not reported. The patient does not remember which arm she received the vaccine in. Patient had no adverse reactions.  The patient received second booster dose on 31-MAR-2022.  Lot number 041D21A expiration date was not provided. The patient did not remember which arm she received the vaccine. Patient had no adverse reactions.  Hives and swelling on both wrists. Swelling was so bad the patient could not bend her wrists. The patient went to the walk-in clinic on Saturday 17-SEP-2022 where she was given a Prednisone taper and told to take 25mg of Benadryl along with 20mg of Pepcid. On Sunday the patient woke up with a swollen bottom lip and hives on her wrists and face. Patient's wrists continued to swell. Patient had swelling above her right eye. Patient has an asthma cough. Patient had welts on her waist which are getting better. The patient went back to the walk-in clinic and was told to continue taking Prednisone and take Hydroxyzine instead of Benadryl. The lip swelling got worse on Monday and the patient went to see her Physician. The Doctor sent her to the Emergency Room. The patient was given IV Steroids and Diphenhydramine and was kept overnight for observation. In the last 4 hours on 21-SEP-2022 patients left eye is swollen and almost shut. Face and neck had hives. Forehead was totally swollen, and it hurt. The patient was referred to a dermatologist and she will see the Dermatologist on 22-Sep-2022.   This case was linked to MOD-2022-648652, MOD-2022-648680 (Patient Link).