Age: 1.43
Sex: M
Vaccine: DTAPIPVHIB, HEPA, MMR, PNC, VARCEL, DTAPIPVHIB, HEPA, MMR, PNC, VARCEL, DTPPHIB, HEPA, MEA, PNC, VARCEL, DTAP, HEPA, HIBV, IPV, MMR, PNC, VARCEL, DTAPIPVHIB, HEPA, MMR, PNC, VARCEL
Symptoms: Liver function test normal, Motor dysfunction, Pyrexia, Varicella post vaccine, Weight decreased
Clinical narrative: This case was reported by a consumer (subject's grandmother) and described the occurrence of autism in a 17-month-old male subject who was vaccinated with Hep A (manufacturer unspecified), dtpa-polio-hib (non-gsk), MMR (non-gsk), varicella virus vaccine (non-gsk) and PREVNAR (non-gsk). A physician or other health care professional has not verified this report. The subject's medical history included constipation, drug reaction and thrush. Concurrent medical conditions included celiac symptoms nos, flour sensitivity and sensitive to chemicals. Historic vaccination included Hib; manufacturer unspecified; unknown given on 16 December 2008; DTaP; manufacturer unspecified; unknown given 16 December 2008; IPV (non-gsk); non-GSK manufacturer; unknown given on 16 December 2008; and live attenuated human rotavirus vaccine; manufacturer unspecified; unknown given on 16 December 2008. On 23 March 2010 the subject received 1st dose of Hep A (unknown), unspecified dose of DTPa-Polio-HIB (Non-GSK) (unknown), unspecified dose of MMR (Non-GSK) (unknown), unspecified dose of Varicella virus vaccine (Non-GSK) (unknown), unspecified dose of PREVNAR (unknown). In 2010, less than one week after vaccination with DTPa-Polio-HIB (Non-GSK), Hep A, MMR (Non-GSK), PREVNAR and Varicella virus vaccine (Non-GSK), the subject experienced high grade fever up to 105, not eating properly. The subject's physician recommended treating the fever with TYLENOL and sponge baths. About 2 to 3 weeks after vaccination with DTPa-Polio-HIB (Non-GSK), Hep A, MMR (Non-GSK), PREVNAR and Varicella virus vaccine (Non-GSK), the subject experienced chicken pox and "about" 1 month after, the subject experienced weight loss, loss of fine motor skills, non communicative, dysphagia and loss of making eye contact. The grandmother explained that the subject lost about 50 percent of his weight, lost 80 percent of his fine motor skills. According to the grandmother, prior to these vaccinations, at the subject's last physical he was noted as normal growth and development. About 4 months after vaccination with DTPa-Polio-HIB (Non-GSK), Hep A, MMR (Non-GSK), PREVNAR and Varicella virus vaccine (Non-GSK), the subject experienced autism. At the time of the report, the grandmother explained that the subject had recovered to about 90 percent and now attended a school for special education students. This case was assessed as medically serious by GSK. At the time of reporting the outcome of the events was unspecified except the autism was considered as improved. After the next vaccination with Hep A the events recurred. On 09 March 2012, the subject was vaccinated with HAVRIX and experienced some of the same events plus different events. See case A0970857C for details. Prior to these vaccinations, the subject was vaccinated with DTaP on 16 December 2008 and experienced some of the same events plus some different events. See case A0970857A for details.