Sex: F
Vaccine: TYP
Symptoms: Urticaria
Clinical narrative: SWELLING PURPLE AND NOW RED MARKS FROM HEALING; SWELLING PURPLE AND NOW RED MARKS FROM HEALING; TRAVELLED TO THE ENDEMIC AREA THE DAY AFTER SHE FINISHED THE LAST DOSE OF VIVOTIF; LITTLE RED SPOTS; NON-STOP ITCHING/ SO MUCH ITCHING ON HER STOMACH AND LITTLE ITCHING ON HER BACK; STOMACH WAS COVERED IN HIVES/ WAS BEHIND HER EARS AND ON HER NECK/ STARTED APPEARING UNDER EYES/ URTICARIA/ WELTS/ RASH/ NETTLE RASH; DIARRHEA AFTER TAKING THE THIRD DOSE; This spontaneous case report (PVX2019-1625) was received from a consumer on 21-Jun-2019. It describes a female consumer who reported experiencing events- "stomach was covered in hives/ was behind her ears and on her neck/ started appearing under eyes/ urticaria/ welts/ rash/ nettle rash", having little red spots, non-stop itching/ so much itching on her stomach and little itching on her back, diarrhea after taking the third dose, and swelling purple and now red marks from healing, after the administration of Vivotif for an unknown indication. She also travelled to endemic area the day after she finished the last dose of Vivotif.  Case report: The consumer took the third dose of Vivotif on 06-Feb-2019 and after that, she experienced hives, urticaria, little red spots, itching, and diarrhea. She stated that she had hives everywhere, urticaria, little red spots, diarrhea, tremendous itching (also stated non-stop itching), welts, and rash. Her stomach was covered in hives when she was travelling. She stated that it looked like "nettle rash" with hives and it spread behind her ears and on her neck. She stated that last week (from date of report), it started appearing under her eyes. She stated that she had swelling (purple in colour), and also there were appearing red marks from healing. Moreover, she had much itching on her stomach and little itching on her back.  She took two cetirizine during the day on 19-Feb-2019 and a week after, she started taking one Benadryl (diphenhydramine) at night. Both the medicines provided relief to itching and red spots. She also took ciprofloxacin and amoxicillin (took on 09-Feb-2019 and 10-Feb-2019), but it did not work for her. She also took some over the counter medicines.    Concomitant medication included Vitamin (once in a day).  Action taken with Vivotif with respect to the events was dosage maintained, except for the event "travelled to endemic area the day after she finished the last dose of Vivotif" it was not applicable.  The consumer had not recovered from the events. While the clinical outcome of the event "travelled to endemic area the day after she finished the last dose of Vivotif" was unknown.  Company's Comment: In this case, it was reported that a female consumer experienced the following events "stomach was covered in hives/ was behind her ears and on her neck/ started appearing under eyes/ urticaria/ welts/ rash/ nettle rash", having little red spots, non-stop itching/ so much itching on her stomach and little itching on her back, diarrhea after taking the third dose, and swelling purple and now red marks from healing, after the administration of Vivotif. There seems to be a temporal association between the intake of the vaccine and the events. Hence, the causality of the events with Vivotif is assessed as possible. ; Sender's Comments: Company's Comment: In this case, it was reported that a female consumer experienced the following events "stomach was covered in hives/ was behind her ears and on her neck/ started appearing under eyes/ urticaria/ welts/ rash/ nettle rash", having little red spots, non-stop itching/ so much itching on her stomach and little itching on her back, diarrhea after taking the third dose, and swelling purple and now red marks from healing, after the administration of Vivotif. There seems to be a temporal association between the intake of the vaccine and the events. Hence, the causality of the events with Vivotif is assessed as possible.