Age: 66.0
Sex: M
Vaccine: COVID19
Symptoms: Chest pain, Dyspnoea, Myocardial infarction, Myocarditis, Rhinorrhoea
Clinical narrative: struggled for air, flat lined 2x; pain in chest, had a heart attack again /flat lines 2x; pain of chest; Myocarditis diagnosed /Hospitalization due to myo/pericarditis; Nose starts running and goes through Kleenex often; This spontaneous case was reported by a consumer and describes the occurrence of MYOCARDIAL INFARCTION (pain in chest, had a heart attack again /flat lines 2x), CHEST PAIN (pain of chest), DYSPNOEA (struggled for air, flat lined 2x) and MYOCARDITIS (Myocarditis diagnosed /Hospitalization due to myo/pericarditis) in a 66-year-old male patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 008C21A and 039B21A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     The patient's past medical history included Myocarditis on 25-Aug-2021 and Surgery (have had 162 surgeries in lifetime).   On 20-Apr-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 19-May-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 25-Aug-2021, the patient experienced MYOCARDITIS (Myocarditis diagnosed /Hospitalization due to myo/pericarditis) (seriousness criteria hospitalization and medically significant). On 15-Sep-2021, the patient experienced MYOCARDIAL INFARCTION (pain in chest, had a heart attack again /flat lines 2x) (seriousness criteria hospitalization and medically significant) and CHEST PAIN (pain of chest) (seriousness criterion hospitalization). On an unknown date, the patient experienced DYSPNOEA (struggled for air, flat lined 2x) (seriousness criterion hospitalization) and RHINORRHOEA (Nose starts running and goes through Kleenex often). The patient was hospitalized on 15-Sep-2021 due to CHEST PAIN, DYSPNOEA, MYOCARDIAL INFARCTION and MYOCARDITIS. The patient was treated with NITROGLYCERIN for Adverse event, at an unspecified dose and frequency and OXYGEN for Adverse event, at an unspecified dose and frequency. At the time of the report, MYOCARDIAL INFARCTION (pain in chest, had a heart attack again /flat lines 2x), CHEST PAIN (pain of chest), DYSPNOEA (struggled for air, flat lined 2x), MYOCARDITIS (Myocarditis diagnosed /Hospitalization due to myo/pericarditis) and RHINORRHOEA (Nose starts running and goes through Kleenex often) outcome was unknown.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On 25-Aug-2021, Cardiac stress test: abnormal (abnormal) failed stress test miserably. On 25-Aug-2021, Ejection fraction: 70 (abnormal) ejection fraction rate was 70%. On 15-Sep-2021, SARS-CoV-2 test: negative (Negative) Negative. On 16-Sep-2021, Catheterisation cardiac: normal (normal) catherization and stent was scheduled, but there was no blockage.. On an unknown date, Ejection fraction: 45 (abnormal) ejection fraction now is 45%.         No concomitant medication were reported.  Patient was scheduled for catherization and stent was scheduled, but there was no blockage.  Company Comment: This case concerns a  66-year-old, male patient with  relevant medical history of myocarditis, who experienced the expected event of Myocarditis, and unexpected events of Chest pain, Dyspnea, and Myocardial Infarction. The event myocarditis occurred approximately 4 months 6 days after the second dose of mRNA-1273 (Moderna Covid-19 vaccine); while patient experienced chest pain, dyspnea and was diagnosed with myocardial infarction approximately 22 days afterwards. The rechallenge was not applicable as events occurred after second dose. This patient's medical history remains a contributory factor. The benefit-risk relationship of mRNA-1273 (Moderna Covid-19 vaccine) is not affected by this report.; Sender's Comments: This case concerns a  66-year-old, male patient with  relevant medical history of myocarditis, who experienced the expected event of Myocarditis, and unexpected events of Chest pain, Dyspnea, and Myocardial Infarction. The event myocarditis occurred approximately 4 months 6 days after the second dose of mRNA-1273 (Moderna Covid-19 vaccine); while patient experienced chest pain, dyspnea and was diagnosed with myocardial infarction approximately 22 days afterwards. The rechallenge was not applicable as events occurred after second dose. This patient's medical history remains a contributory factor. The benefit-risk relationship of mRNA-1273 (Moderna Covid-19 vaccine) is not affected by this report.