Age: 65.0
Sex: M
Vaccine: PNC20, PNC20
Symptoms: Biopsy skin abnormal, Discomfort, Eczema, Pruritus, Skin exfoliation
Clinical narrative: severe psoriasis flare up/ Got worse from July all the way up to the 3rd week of August/ covered body up/itch/inflamed; stay up late at night; This is a spontaneous report received from a Consumer or other non HCP from medical information team.  A 65-year-old male patient received pneumococcal 20-val conj vac (dipht CRM197 protein) (PREVNAR 20), on 19Jun2024 at 14:30 as dose 1, single (Lot number: HH9323, Expiration Date: 31May2025) at the age of 65 years intramuscular, in left arm for immunisation. The patient's relevant medical history included: "Celiac" (ongoing); "autoimmune disease/twitchy immune system" (ongoing); "Psoriasis" (ongoing), notes: under control with no medications for decades; "Psoriatic arthritis", start date: 1991 (ongoing); "diffuse large B-cell non Hodgkin's lymphoma", start date: 2017 (unspecified if ongoing). There were no concomitant medications. Past drug history included: Chop for diffuse large B-cell non Hodgkin's lymphoma. The following information was reported: PSORIASIS (non-serious) with onset Jul2024, outcome "not recovered", described as "severe psoriasis flare up/ Got worse from July all the way up to the 3rd week of August/ covered body up/itch/inflamed"; INSOMNIA (non-serious) with onset Jul2024, outcome "unknown", described as "stay up late at night". The event "severe psoriasis flare up/ got worse from july all the way up to the 3rd week of august/ covered body up/itch/inflamed" required physician office visit. Relevant laboratory tests and procedures are available in the appropriate section.  Additional information: Caller (patient) wanted to know if Pfizer has had other reports of people with psoriasis or other auto immune disorders that have reported flare ups which were made worse by this vaccine. The patient had been given the Prevnar 20 vaccine, had a history with autoimmune disease which includes psoriasis, had a twitchy immune system, had decades of pretty much no problems and have never had anything this severe this proximate to a vaccine. Basically this is his first experience with a conjugate vaccine of this design. He was convinced something triggered this profound attack of psoriasis he had, even thought he had underlying psoriasis. It was pretty much under control with no medications for decades, so something triggered it and the only thing he can think of that might have is something that was designed to trigger his T cells to go into defense mode. He stay up late at night because his itch. this has been miserable. The literature is replete with examples of this kind of a aggravation of underlying conditions. For a person that was in control of auto immune disorders and experienced what he had experienced, except on 19Jun when given vaccine. Your vaccine poisoned people like him, it will be old people because babies don't have psoriasis. He was emotional because he was miserable. It was scary. Caller (patient) called about Prevnar 20, wants to report that caller believes caller had a severe psoriasis flare up that is related to this by proximity, date, and circumstance. Has been more than a nuisance for the past 60 days, has changed caller's life, is awful. Weight is very low, 125 or 130 pounds. Severe psoriasis flare up didn't start on a moment, builds up, so between 01Jul2024 and 08Jul2024. Continued getting worse over the next four weeks. Caller has been to dermatologist twice, has been exposing himself to sun which has been only help for it. Got worse from July all the way up to the 3rd week of August. Has been persistent. Caller had psoriasis for 40 years, has underlying condition, but has never had anything close to this level of attack, not even close, this makes every other experience with the condition minute compared to this. Psoriasis has been under control for over a decade, without medicating, caller has used no medication until this event. Had no need to medicate until this happened and covered body up. Caller stated caller doesn't want to forget to mention that caller was a person with autoimmune problems, obviously, has psoriasis, was pretty much in remission. Has psoriatic arthritis, which has been in remission also since 1991, so over 30 years, with no medication. Caller is celiac and once figured that out a lot of the arthritis symptoms resolved themselves after damaging caller, but stated there is a difference between long term damage and inflammation. Active inflammation days were pretty much behind caller, until this. Caller takes no drugs for about four decades (as reported). Caller has a very twitchy immune system, has psoriasis, Celiac, psoriatic arthritis, which caller stated were all resolved (as reported). In 2017 caller got diagnosis of non Hodgkin's lymphoma, clarified diffuse large B-cell non Hodgkin's lymphoma, was in left inguinal gland in groin. Caller received chemo therapy, CHOP treatments, infusions for 3 months, and has had no recurrence, has been 7 years, that was big a deal. Plays into greater picture of immune system twitchiness, the non Hodgkin's lymphoma was gorilla in the room. Test results: Sees dermatologist which caller has seen for last 20 years, dermatologist has been following this, seen dermatologist twice. Caller became fearful because of severity of attack and unprecedent nature, that it was not psoriasis, and might be something else. Dermatologist biopsied in the inflamed areas to see if it was anything, did two punch biopsies, results confirmed inflammation consistent with psoriasis, which gives some technical milestone, confirms the fact that what is going on is underlying condition, aggravated by something, triggered by the vaccine. Time the vaccination was given around 2:30PM. Anatomical Location of Administration of Pfizer vaccine thinks left upper arm. No additional vaccines administered on same date of the Pfizer suspect. AE(s) required a visit to physician office, went to dermatologist twice, 19Jul2024 and 19Aug2024. No prior vaccinations (within 4 weeks). Dermatologist has even photo documented this, so there is a case here, if anyone proves it. Hoping a pattern can be revealed, if there is a pattern, maybe people that are suspect to auto immune and lymphoma shouldn't be given vaccines that rely on active agents and active B cells that mediate all of this disease. Thinks poisoned caller.