Age: 12.0
Sex: F
Vaccine: DTAP, MMR, MMR, TD
Symptoms: Abnormal behaviour, Acne, Back pain, Facial palsy, Herpes simplex
Clinical narrative: It has been received from a consumer concerning her 12 year old daughter who on 12/16/1998 was vaccinated with one dose of MMR and DT. It was noted that the pt was supposed to receive Hep B. Subsequently the pt experienced blurred vision, no bowel movements and woke up with Bell's Palsy. Two MRI's were performed which showed no multiple sclerosis. The pt's mother states that she believes is vaccine related. On FU the physician feels that the vaccinations had nothing to do with her experience. He believes the pt contracted Bell's Palsy most probably due to the Epstein-Barr virus. Physician also reports pt is "completely normal" and had no brain damage. Further FU: A couple of weeks post vax the pt developed "warts" on the back of her left ankle. Treated with "every prescription medication including fungus meds and OTC wart meds", however the warts persisted. March 1999 the pt experienced neurotic eye movements, dizzy spells, croup cough, vomiting and Bell's Palsy. The follow up received on 1/11/01 states the pt's mother reported that she is "100% psoitive that her daughter had this reaction because she had intraviral disease-mono." The pt's mother indicated that she would like to have "further testing" done. Follow up info fromt he pt's mother indicated that her daughter has a past medical history of thrust (2 months old), varicella, 17 upper respiratory infections (between the age of 2 months and 6 years and she was hospitalized for 3 of them), common cold, sinus infection (1996 and 1997) and an allergy to pcn and "very large tonsils from fighting off infections as an infant and toddler." She also indicated that her daughter's blood type is ABO and that "most doctors are not knowledgeable with the ABO blood type or the different types of hypersensitivity adverse reaction that could occur in a person with this blood type after immunization." Two weeks post vaccinatio, on approximately 12/30/98 the pt developed 5 bumps on the back of her ankle that "looked like chickenpox" according to the pt's mother. Her physician indicated that it was a skin fungus and prescribed fungus cream. Furthermore, she stated that on 3/18/99 her daughter had a "severe toxic allergic hypersensitivity type IV reaction" and "should have never received a live vaccine because of her ABO blood type." The pt's mother felt that the sever toxic allergic hypersensitivity type IV reaction was life threatening and that it resulted in permanent disability. On 3/18/99 the pt experienced double vision. On 4/19/99 she experienced bronchospasm, followed by another episode of bronchospasm/asthma on 5/16/99 and bronchospasm/croup on 5/21/99. On 8/21/99 the pt was seen in the ER for an exacerbation of asthma. The pt was treated with Augmentin. On 8/19/99 she expereinced dizzy spells, abdominal cramps, and "no bowel movements in weeks." On 9/27/99 she experienced anothe rbronchospasm and a sinus infection. On 10/12/99 the pt again experienced a sinus infection. On 11/19/99 the pt developed Bell's palsy. The mother indicated that on 12/3/99 an MRI was done. The impression by the radiologist was "multiple white matter plaques are identified withint he brain. The majority of these are present within the cerebral hemispheres. There is an isolated lesion present within the right brachium pontis. These findings would be compatible with demyelinating disease. Due to their appearance, the most likely diagnosis would be early multiple sclerosis in this 13 year old pt, although the possibility that this represents another form of demyelinating or demyelinating disease cannot be excluded. The plaques however do not ahve the appearance of revealed "no significant change from the previous exam with multiple deep matter bright lesions. Only one of these lesions enhances and despite the pt's age, this most likely represents early demyelinating disease such as multiple sclerosis." The radiologist indicated that inflammatory disease may have a similar appearance and should be ruled out. In January 2000 the bumps on the pt's ankle that were diagnosed as a skin fungus persisted. She was seen again by a physician and diagnosed with warts. The mother indicated that hte wart medicine was not effective and as of 9/8/00 the "bumps" persisted. Subsequently, on 3/10/00 the pt had a lumbar puncture done and the pt's mother stated that "multiple sclerosis was ruled out by lumbar puncture." Additionally, it was noted that "the neurologist told us that her neurological findings were caused by a EBV viral process and she would be fine." Two days post lumbar puncture the pt developed 'strep tonsillitis." It was also noted that the pt experienced a headache and neck pain in a few days after the lumbar puncture. The pt's mother sought a second opinion. On 9/5/00 a repeat MRI was done. The results indicated that "the white matter plaques now has the appearance of acute disseminated encephalomyelitis or multipole sclerosis." On approximately 9/1/00 the pt experienced weakness on the left side of her face. The pt's mother reported additional findings regarding her daughter, but did not specify the onset of each symptoms. The findings are as follows: her daughter's left toes sometimes separate and become stiff for several minutes; cold sores on her lip and inside of her nostrils; "real bad acne" only on the left side of her forehead; personality and normal behavior change; tingling sensation down her spine when seh sneezes; her grades went from a high B average to a low C; swollen gums and "her tonsils have gotten even larger." Follow up info was received and it was indicated that a 12 year old female inadvertently received DTP or DT and MMR on 12/16/98. "A couple of weeks" post vaccination, she expereinced a "hypersensitivity allergic reaction with DTaP or DT" manifested by "warts on the back of her left ankle." The pt's mother indicated that hte pt was treated with "every prescription medication including fungus medications and OTC wart medications"; however the warts persisted. In March 1999 the pt experienced "neurotic eye movements, dizzy spells, croup cough, vomiting, and Bell's palsy." In December 1999 a MRI showed "white matter lesions." A second MRI also showed "white matter lesions." It was indicated that the pt had been seen in the ER several times. During one of the ER visits, the pt was treated with pcn 250mg orally and experienced an allergic reaction. The pt was then taken to a ER and was treated with pcn 400mg orally "to counteract allergic reaction," other medical event (OMIC).