Sex: F
Vaccine: VARZOS
Symptoms: Dyskinesia, Dysstasia, Hypoaesthesia, Paraesthesia
Clinical narrative: tingling in her right leg; involuntary movement in her forehead and eyes where the shingle was located, her forehead would stretch causing eyes; could not stand on her own, due to not having feeling in that part of the leg; not having feeling in that part of the leg/her right toes to the right knee cap was numb; This non-serious case was reported by a other health professional via other manufacturer and described the occurrence of tingling of extremity in a female patient who received Herpes zoster (Shingles vaccine) for prophylaxis.   Co-suspect products included tofacitinib citrate (Xeljanz Xr) (batch number 8179947, expiry date 31-JUL-2027) for rheumatoid arthritis.   The patient's past medical history included ophthalmic herpes zoster (The patient reported having shingles in 2005 and another year, exact date unknown, shingles presented near her eye, exact eye unknown).   In APR-2024, the patient received the 1st dose of Shingles vaccine. In MAY-2024, the patient started Xeljanz Xr (oral) 11 mg daily (11 mg daily). On an unknown date, an unknown time after receiving Shingles vaccine, the patient experienced tingling of extremity (Verbatim: tingling in her right leg), difficulty in standing (Verbatim: could not stand on her own, due to not having feeling in that part of the leg), numbness of lower extremities (Verbatim: not having feeling in that part of the leg/her right toes to the right knee cap was numb) and movements involuntary (Verbatim: involuntary movement in her forehead and eyes where the shingle was located, her forehead would stretch causing eyes). The action taken with Xeljanz Xr was unknown. The outcome of the tingling of extremity was resolved and the outcome of the difficulty in standing and numbness of lower extremities were resolved (duration 3 weeks) and the outcome of the movements involuntary was not reported.   It was unknown if the reporter considered the tingling of extremity, difficulty in standing, numbness of lower extremities and movements involuntary to be related to Shingles vaccine.     It was unknown if the company considered the tingling of extremity, difficulty in standing, numbness of lower extremities and movements involuntary to be related to Shingles vaccine.   Additional Information: GSK Receipt Date: 10-SEP-2024 The other health professional reported that prior to the start of therapy May 2024, exact date unknown, patient reported received the 1st shingles vaccine in April 2024, exact date unknown, after received the shingle vaccine, her right toes to the right kneecap was numb, she could not stand on her own, due to not having feeling in that part of the leg, patient reported having these episodes at least one time a week for 3 weeks, (dates unknown) after received.  The 1st shingles vaccines, episodes usually happened at nighttime, lasted 15-20 minutes each time.  The medicinal doctor was made aware and advised the patient to get the 2nd shingles vaccine, due to this adverse event patient did not get the 2nd shingles vaccine.  The patient reported numbness and tingling in her right leg (toes up to the kneecap) that randomly occurs at least once every couple of weeks. The patient reported that having shingles in 2005 and another year, exact date unknown, shingles presented near her eye, exact eye unknown.  After the start of therapy in May 2024 the patient reported involuntary movement in her forehead and eyes where the shingle was located, her forehead would stretch causing eyes to stretch wide open involuntarily, no further symptoms or information was provided.