Age: 0.7
Sex: M
Vaccine: FLU3
Symptoms: Mood altered, Motor dysfunction, Musculoskeletal discomfort, Pyrexia, Speech disorder
Clinical narrative: Landen was completly normal child until after his 6 month shots he quit putting on weight as fast as he was prior to them. He learn to walk and was talking but was not putting on the wieght I felt he should have. At 8 months he recieved a Influenza shot.  After that shot later he came down with a terrible fever which persisted for three days.  He then came down with exczema which he never had before, he became very aggressive, his sleep patterns got very unorganized he wouldn't sleep only a half and hour during the day and was very crabbie and unhappy child.  He then had croup and recieved a steroid then within a few weeks landen started falling down on his butt and acted week.  he was admitted to the hospital because he was holding his neck back and his eyes looked glazed over and cloudy. An MRI showed Demylination of the brain. We were told our son had a Leukodystrophy of some sorts and probably would not live 6 months.  Those test came back negative, a muscle biopsy was done and a show of mitochondrial disorder was there but we were told it was secondary to something but we didn't know what.  The neurologist put landen on a steroid per our asking to see if he would improve his ability to walk, talk, eat etc. It worked so we are unsure if he suffered from encephalitis, as there was one case of it that looked similar to landens MRI.  The steroids helped and landen started eating better and has started getting much better. Landen had a hair test and blood test done on toxins and had both mercury and aluminum in high amounts in his body which have been detoxifying from his body. I have read about MMR reactions and a couple of stories match landens to a tee, maybe he recieved this accidentally. But one thing is for sure what ever shot he recieved on December 15th, is what spiraled my son into this disability. He is now been diagnosed on the Autism Spectrum for speech problems and motor function problems. He is unable to crawl or walk at this time.  9/5/08 Reviewed new PCP medical records which included several hospital & consult records as well as additional previous PCP medical records. FINAL DX: probable mitochondrial cytopathy characterized by leukodystrophy. Records reveal initial hospitalization 3/26-3/31/2007 for Ataxia.  Ophtho, ID & neurology consults done.  Had 7-10 days of progressive clumsiness & difficulty walking.  D/C to home w/PT/OT & referral to early intervention.  Readmitted to second hospital next day for dehydration & weakness. NGT inserted.  Continued to lose developmental milestones.  Seen out of state at neuro & bone marrow transplant center, no diagnosis provided.  5/07 2nd opnions peds neuro consult.  Given a trial of steroids & improved.  Second hospitalization 5/07 for respiratory distress & acute laryngeal tracheobronchitis.  GI & Genetic clinic consults & swallow study done 7/07.  6/24/08 Reviewed PCP vax records & medical records for 7/5/2006-7/13/2007. FINAL DX: Records reveal patient w/eczema of face on day of vaccination otherwise w/normal G&D.  RTC 1/30/07 w/rash all over body, dx w/eczema.  RTC 2/21 w/croup, 2/23 w/increased croup s/s.  RTC 3/23 w/cold s/s x 3 wks, pulling at ears, loses balance & not acting himself; dx w/sinusitis.  RTC 3/26 w/worsened ataxia & developmental regression, irritable esp w/neck movement, tired, poor eye contact.  Admitted to hospital at that time, MRI c/w leukodystrophy & encephalopathy.  Neuro consult done.  Tx w/steroids & had some improvement in neuro s/s.  Developed URI & conjunctivitis.  Skin & muscle biopsies done.  Multiple bouts of diarrhea & constipation.  Referred to GI.   Developed croup & resp distress 5/07 & hospitalized again.    7/4/08 Reviewed surgeons medical records of skin & muscle biopsy done 6/5/2007 FINAL DX: leukodystrophy Records reveal patient experienced acute onset of frequent falls w/weakness, right greater than left.  Txw/steroids & had improvement.  7/8/08 Reviewed hospital ER records of 7/20/07. FINAL DX: fever, likely viral syndrome; developmental arrest & regression. Records reveal patient experienced progressive deterioration & loss of function w/o clear etiology.  Improved w/high dose steroids temporarily.  7/8/08 Also received referral from neurology clinic to cardiology clinic for echocardiogram 5/30/08 to r/o cardiomyopathy.