Age: 54.0
Sex: F
Vaccine: VARZOS
Symptoms: Arthralgia, Body temperature increased, Fatigue, Hyperaesthesia, Malaise
Clinical narrative: Fever of about 100.7 degree Fahrenheit; Slept all day yesterday / had to force herself to stay awake today; "felt puffy" / the body had a "swelling sensation"; Neuropathic pain; Felt like needles were at the bottom of the feet; Felt sluggish; Tired, extreme fatigue; Muscle pain; Body and/or arthritic pain; Body and/or arthritic pain; Increased in sensitivity; Her overall entire body does not feel that great/ feeling "knocked down"; This case was reported by a consumer via call center representative and described the occurrence of feeling swollen in a 54-year-old female patient who received Herpes zoster (Shingrix) for prophylaxis.   Concurrent medical conditions included rheumatoid arthritis. Concomitant products included methotrexate.   On 4th January 2021, the patient received the 2nd dose of Shingrix (intramuscular). On 4th January 2021, 2 hrs after receiving Shingrix, the patient experienced feeling swollen, neuropathic pain, pins and needles, sluggishness, tiredness, muscle pain, arthritic pains, general body pain and hyperesthesia. On 5th January 2021, the patient experienced fever and sleepiness. In January 2021, the patient experienced feeling unwell. On an unknown date, the outcome of the feeling swollen, neuropathic pain, pins and needles, sluggishness, tiredness, muscle pain, arthritic pains, general body pain, hyperesthesia, sleepiness and feeling unwell were recovering/resolving and the outcome of the fever was recovered/resolved.   It was unknown if the reporter considered the feeling swollen, neuropathic pain, pins and needles, sluggishness, tiredness, muscle pain, arthritic pains, general body pain, hyperesthesia, fever, sleepiness and feeling unwell to be related to Shingrix.  Additional details were provided as follows: The reporter was patient's husband. The patient took her dose of methotrexate (7 tablets) for rheumatoid arthritis the same day of vaccination before bed.  The patient had received the 2nd dose of the Shingrix vaccine on past Monday night, at around 6pm at the left upper arm. After 2 hours of vaccination, the patient felt puffy and the body had a swelling sensation. She also experienced neuropathic pain, where it felt like needles were at the bottom of the feet, felt sluggish, tired, extreme fatigue, muscle pain, body and or arthritic pain, and an increase in sensitivity. The day after receiving the vaccine, the patient started running a fever of about 100.7 that lasted for a few hours but had since resolved. The patient slept all day on the day before reporting date, and had to force herself to stay awake on the reporting date. The patient's overall entire body did not feel that great. All other events other than fever were still ongoing till the time of reporting, but had improved since the first day. The patient did not have nausea or diarrhea.  The reporter stated that they were mainly concerned about the tiredness and feeling of "knocked down."  Not all information was available. The reporter consented to follow-up and gave permission to follow-up with healh care professional, and provided the contact information.