Age: 56.0
Sex: M
Vaccine: PNC20, PNC20
Symptoms: Hypoaesthesia, Light chain analysis increased, Neuralgia, Neuropathy peripheral, Pain in extremity
Clinical narrative: Serum free light chain; kappa and lambda light chain; Both were slightly high; bilateral hands and feet tingling and numbness kind of weird and bothersome; bilateral hands and feet tingling and numbness kind of weird and bothersome; Again have Bilateral shoulder pain; every night kind of wake up from the shoulder pain; some like local injection site pain; mild Guillain-Barre; there is kind of tibial and small nerve fiber problem; This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP). The reporter is the patient.  A 56-year-old male patient received pneumococcal 20-val conj vac (dipht CRM197 protein) (PREVNAR 20), on 18Apr2023 as dose number unknown, single (Batch/Lot number: unknown) at the age of 56 years intramuscular, in left arm for pneumococcal immunisation. The patient's relevant medical history included: "Borderline hypertension" (unspecified if ongoing); "B12 deficiency" (unspecified if ongoing), notes: Methylmalonic acid which is for B12 deficiency. Concomitant medication(s) included: AMLODIPINE taken for hypertension. The following information was reported: VACCINATION SITE PAIN (non-serious) with onset 27Apr2023, outcome "unknown", described as "some like local injection site pain"; ARTHRALGIA (non-serious) with onset 30Apr2023, outcome "not recovered", described as "Again have Bilateral shoulder pain; every night kind of wake up from the shoulder pain"; PARAESTHESIA (non-serious), HYPOAESTHESIA (non-serious) all with onset 12May2023, outcome "not recovered" and all described as "bilateral hands and feet tingling and numbness kind of weird and bothersome"; GUILLAIN-BARRE SYNDROME (medically significant) with onset 2023, outcome "unknown", described as "mild Guillain-Barre"; NEUROPATHY PERIPHERAL (medically significant) with onset 2023, outcome "unknown", described as "there is kind of tibial and small nerve fiber problem"; LIGHT CHAIN ANALYSIS INCREASED (non-serious), outcome "unknown", described as "Serum free light chain; kappa and lambda light chain; Both were slightly high". The patient underwent the following laboratory tests and procedures: Alanine aminotransferase: Normal; Amino acid level: Normal; Glycosylated haemoglobin: Normal; Light chain analysis: High; High; Prostatic specific antigen: Normal; Red blood cell sedimentation rate: Normal; Rheumatoid factor: Normal; Vitamin B12: Deficiency; Normal. Therapeutic measures were taken as a result of arthralgia.  Clinical course: Consumer stated, "I just wanted to report, likely side effect of the vaccine Prevnar 20. Basically, I received a Prevnar 20 from the withheld Pharmacy here on 18Apr2023. So, around like 27Apr2023, I mean obviously in first few days there are some like local injection site pain, which comes and went away like a regular response I experienced with other vaccines in the past just like, Flu Vaccine (Unspecified Flu Vaccine). So, basically, I received the Prevnar 20 at a local pharmacy, withheld Pharmacy on 18Apr2023. Then, I experienced some local injection site pain, that went away and no problem but on like late April, it was the 30Apr2023, I again have Bilateral shoulder pain which kind of lasting for 4-5 days and every night kind of wake up from the shoulder pain. So, I took Advil it turned out kind of help during the daytime, but somehow at night it come back again, the pain come back again (Hence Advil captured as Suspect conservatively) So, that basically went away approx. about 4 to 5 days but the most bothersome is that around like a 12May2023 all of the sudden, I began to have like a Bilateral numbness and tingling in hands and the feet, like both the bilateral hands and feet tingling and numbness kind of weird and bothersome and till today, I am still feeling the same tingling, numbness so, I went to my Primary Care Physician office. I met a neurologist, there is some suggestion that this could be called a mild Guillain-Barre, maybe it associated with the vaccination, but they did some regular neural diagnostic testing in arms and legs. I think the 5th nerve seems okay, but obviously there is kind of tibial and small nerve fiber problem. I am still feeling them, kind of like numbness and tingling." When paraphrased the above concern, consumer stated, "Right." Consumer was informed about the role of Pfizer Drug Safety department. Consent to follow up: Consumer stated, "Sorry, you can go ahead if you have questions you can ask now (Not appropriately clarified hence tab left unchecked)."  No follow-up attempts are possible; information about lot/batch number cannot be obtained. No further information is expected.