Sex: F
Vaccine: VARZOS, VARZOS
Symptoms: General symptom, Pain, Post herpetic neuralgia, Vaccination failure
Clinical narrative: Suspected vaccination failure; some shingles symptoms; I have postherpetic neuralgia with no rash; the pain brings you to your knees/pain is like a crossed between a taser and being burned, it is just horrific; This serious case was reported by a consumer via call center representative and described the occurrence of vaccination failure in a elderly female patient who received Herpes zoster (Shingrix) for prophylaxis.   Co-suspect products included Herpes zoster (Shingrix) for prophylaxis.   On an unknown date, the patient received the 2nd dose of Shingrix and the 1st dose of Shingrix. On an unknown date, more than 2 years after receiving Shingrix and Shingrix, the patient experienced vaccination failure (Verbatim: Suspected vaccination failure) (serious criteria GSK medically significant), shingles (Verbatim: some shingles symptoms), post herpetic neuralgia (Verbatim: I have postherpetic neuralgia with no rash) and pain (Verbatim: the pain brings you to your knees/pain is like a crossed between a taser and being burned, it is just horrific). The patient was treated with lidocaine and valaciclovir (Valacyclovir). The outcome of the vaccination failure was unknown and the outcome of the shingles and post herpetic neuralgia were not resolved and the outcome of the pain was not reported.   It was unknown if the reporter considered the vaccination failure, shingles, post herpetic neuralgia and pain to be related to Shingrix and Shingrix.     The company considered the vaccination failure to be related to Shingrix and Shingrix. The company considered the shingles, post herpetic neuralgia and pain to be unrelated to Shingrix and Shingrix.   Additional Information: GSK Receipt Date: 11-JUN-2024 The patient was in her mid-sixties. The patient reported that 5 years ago she got both doses of Shingrix vaccine and she was the one of the few cases that has still developed some shingles symptoms. The patient at the time of reporting (now) had postherpetic neuralgia with no rash. The patient stated that it was started within the last 6 months. The pain brings you to your knees, the pain was like a crossed between a taser and being burned, it was just horrific. This was on a recurrent daily basis and multiple times a day. The patient stated it was getting worse, she followed up with her physician. The physician had prescribed lidocaine patches and valacyclovir for treatment.  GlaxoSmithKline had what they need, now with the patient's case and might be others a 3rd dose or booster for Shingrix should be considered. The patient provided limited information. The patient declined to provide complete demographics for follow-up. This case was considered as suspected vaccination failure as details regarding laboratory confirmation regarding shingles were unknown at the time of reporting.; Sender's Comments: Vaccination failure is  listed events which is considered related to GSK vaccine Shingrix dose I  and Shingrix dose II.  Herpes zoster , Post herpetic neuralgia  and Pain are unlisted events which are considered unrelated to GSK vaccine Shingrix dose I  and Shingrix dose II.