Age: 73.0
Sex: F
Vaccine: VARZOS
Symptoms: Balance disorder, Blood pressure fluctuation, Dizziness, Fatigue, Gait disturbance
Clinical narrative: blood pressure was going up and down; Wobbly; Dizzy; Slight headache; Muscle Aches; Inability to grip well; staggering walk; Extremely tired; This case was reported by a consumer via call center representative and described the occurrence of tiredness in a 73-year-old female patient who received Herpes zoster (Shingrix) for prophylaxis.   Concurrent medical conditions included liver transplantation. Concomitant products included Immunosuppressant Drug (Nos).   On 12th August 2019, the patient received the 1st dose of Shingrix (intramuscular). On 12th August 2019, less than a day after receiving Shingrix, the patient experienced tiredness. On 13th August 2019, the patient experienced unsteadiness, dizziness, headache, muscle pain, muscle weakness and staggering gait. On 15th August 2019, the patient experienced blood pressure fluctuation. On 14th August 2019, the outcome of the headache and muscle weakness were recovered/resolved. On 16th August 2019, the outcome of the unsteadiness, dizziness and staggering gait were recovered/resolved. On an unknown date, the outcome of the tiredness, muscle pain and blood pressure fluctuation were unknown.   It was unknown if the reporter considered the tiredness, unsteadiness, dizziness, headache, muscle pain, muscle weakness, staggering gait and blood pressure fluctuation to be related to Shingrix.  Additional details were provided as follows: The patient received Shingrix in left arm. The caller saw her transplant coordinator a week before Shingrix vaccination and reported all was well with her body and no sickness. The caller reported the day of vaccination she was tired due to a hard week but nothing wrong or no illness at time of vaccination. After receiving vaccine, caller reported going home doing some things but had to end up driving roughly 100 miles as usual for a business trip. When she arrived at the hotel she reported being extremely tired and going to bed early due to exhaustion. The next morning after vaccination, she felt wobbly and dizzy on her feet. The caller reported having a slight headache, muscle aches all over her body, inability to grip well, and having a staggering walk due to wobbly legs. She stayed in bed as much as possible but did not get better all day long. The following morning caller reports feeling a little better and driving home although still very dizzy. When she got home she called the coordinator from liver transplant and they consulted whether to receive 2nd dose of Shingrix. Caller also consulted with her primary care physician, and both practices had same conclusion of not receiving 2nd dose. Caller also reported her blood pressure was going up and down, blood pressure would be high at night but low in the mornings. The caller reported on the day of reporting she was not dizzy anymore and has pretty good strength in her legs. The reporter consented to follow up. Caller reported no fever or nausea, but all muscular. Caller also mentions liver transplant office reported adverse event elsewhere but recommended her to contact GlaxoSmithKline as well.