Age: 66.0
Sex: F
Vaccine: PPV, VARZOS, PPV, VARZOS, FLU4, PPV, VARZOS
Symptoms: Paraesthesia, Tremor, Vibratory sense increased
Clinical narrative: pain soreness in both arms; chest tightness; MS hug/ MS hug which is a constricted feeling from below the breast to her waist; constricted feeling from below the breast to her waist/ buzzing sensation; buzz like feeling / buzzing / she rubs the anterior part of her stomach she feels a buzz like feeling running down her left lower side and also buzzing feeling went around her; feels a little numbness around the eye; wondering if it might be shingles; achiness around the side/body aches; malaise; felt bad; might be experiencing exacerbation of the MS; This case was reported by a physician and described the occurrence of ms aggravated in a 66-year-old female patient who received Herpes zoster (Shingrix) for prophylaxis.   Co-suspect products included PNEUMOCOCCAL VACCINE POLYSACCHARIDE 23 VALENT (PNEUMOVAX 23) for prophylaxis.   The patient's past medical history included ms hug. Previously administered products included Pneumovax with an associated reaction of no adverse event and Zostavax with an associated reaction of no adverse event. Concurrent medical conditions included multiple sclerosis and herpes simplex. Concomitant products included INFLUENZA VIRUS VACCINE INACTIVATED (FLUZONE HD), interferon-beta 1b (Betaseron) and valaciclovir (Valacyclovir).   On 14th October 2020, the patient received Shingrix (intramuscular) and PNEUMOVAX 23. On 14th October 2020, several hours after receiving Shingrix, the patient experienced pain in arm. In October 2020, the patient experienced ms aggravated (serious criteria GSK medically significant), chest tightness, ms hug, abnormal physical sensation, feeling high, eye numbness, shingles, pain, malaise and feeling bad. The patient was treated with steroids nos (Steroids). On an unknown date, the outcome of the ms aggravated, chest tightness, ms hug, abnormal physical sensation, feeling high, eye numbness, shingles, pain, malaise and feeling bad were unknown and the outcome of the pain in arm was recovered/resolved.   It was unknown if the reporter considered the ms aggravated, pain in arm, chest tightness, ms hug, abnormal physical sensation, feeling high, eye numbness, shingles, pain, malaise and feeling bad to be related to Shingrix.   Additional details were reported as follows: The patient received a Shingrix vaccine in her left deltoid intramuscularly and Pnemovax 23 in her right arm both on same day. Within a few hours she started to feel pain soreness in both arms which resolved in a few days. The patient had a medical history of multiple sclerosis and has experienced multiple sclerosis hug previously. But after receiving the vaccine within 3 days she started to feel chest tightness with a multiple sclerosis hug which was a constricted feeling from below the breast to her waist.   When patient rubs the anterior part of her stomach she felt a buzz like feeling running down her left lower side and also buzzing feeling went around her. The patient stated she might be experiencing exacerbation of the multiple sclerosis.  The patient felt a little numbness around the eye and was wondering if it might be shingles. No fever was reported. The patient experienced achiness around her side. She states she may start taking steroids. The patient was on Betaseron. She also takes Valcyclovir 1gm daily for years for herpes simplex.  The patient received Pneumovax and Zostavax in the past and did not had any adverse events. It was unknown if the reporter considered the ms aggravated, pain in arm, chest tightness, ms hug, abnormal physical sensation, feeling high, eye numbness, shingles, pain, malaise and feeling bad to be related to Pneumovax 23. The reporter consented to follow up.