Sex: F
Vaccine: VARZOS, VARZOS
Symptoms: Blood test normal, Chest discomfort, Electrocardiogram normal, Eye swelling, Lip swelling
Clinical narrative: Funny feeling in throat; Hives all over body/ different size hives all over arms, stomach, chest, back and pretty much everywhere; Throat closing; Heavy chest; Swelling all over body / Neck swelling; Lip swelling; eye swelling; Face swelling; This case was reported by a consumer via call center representative and described the occurrence of pharynx strange sensation of in a female patient who received Herpes zoster (Shingrix) for prophylaxis.   Concomitant products included Herpes zoster (Shingrix).   On 31st July 2019, the patient received the 2nd dose of Shingrix .5 ml. On 2nd August 2019, 2 days after receiving Shingrix, the patient experienced pharynx strange sensation of (serious criteria clinically significant/intervention required), hives (serious criteria clinically significant/intervention required), throat constriction (serious criteria clinically significant/intervention required), chest heaviness (serious criteria clinically significant/intervention required), swelling (serious criteria clinically significant/intervention required), lip swelling (serious criteria clinically significant/intervention required), eye swelling (serious criteria clinically significant/intervention required) and facial swelling (serious criteria clinically significant/intervention required). The patient was treated with cetirizine hydrochloride (Zyrtec), epinephrine, steroids nos (Steroids) and benadryl (nos) (Benadryl). In September 2019, the outcome of the hives was recovered/resolved. On an unknown date, the outcome of the pharynx strange sensation of, throat constriction and chest heaviness were recovered/resolved and the outcome of the swelling, lip swelling, eye swelling and facial swelling were unknown.   It was unknown if the reporter considered the pharynx strange sensation of, hives, throat constriction, chest heaviness, swelling, lip swelling, eye swelling and facial swelling to be related to Shingrix.  Additional details were provided as follows: The age at vaccination was not reported. The reporter did not provide the date of birth and medical information. On 1st May 2019, the patient received 1st dose of Shingrix. The patient went to the emergency room with a funny feeling in her throat, hives all over her body, feeling of throat closing, heavy chest and swelling all over her body. The patient also experienced lip swelling, eye swelling, neck and face swelling and different size hives all over arms, stomach, chest, back and pretty much everywhere.  The patient was treated with Epinepherine, Steroids and Benedryl.  The patient went to the home. Next day the patient had same symptoms, returned to the emergency room and received the same treatment that the patient was on in the hospital. The patient sated that, the Benadryl did not do anything for her. The patient was currently being followed by her physician and the patient's physician sent her to an allergist.  An allergist put the patient on Zyrtec one in the morning and one in the evening. They stated that, the symptoms were resolved as of a few days before the time of reporting. At the time of reporting, the patient did not seem to have any hives and that the patient had not any for 4 to 5 days. The patient stated that, either the Zyrtec was working or the reaction was out of her system. No batch number and expiry date were available for Shingrix. The reporter was upset and wanted the GlaxoSmithKline to reimburse for her medical expenses. No additional information was reported. The reporter did not consent to follow up. The outcome of funny feeling in throat, throat closing and chest feeling heavy were reported as recovered/resolved however in source document, it was mentioned as recovered/resolved with sequel.