Age: 0.5
Sex: F
Vaccine: DTAP, HEP, HIBV, IPV, PNC, DTAP, HEP, HIBV, IPV, PNC
Symptoms: Brain oedema, Capillary disorder, Convulsion, Encephalopathy, Gastrointestinal disorder
Clinical narrative: Information has been received from manufacturer as part of a business agreement (manufacturer report numbers U2002-00616 and F2002-01993, case linked with U2002-00340/F2002-01990). It was reported that a 6 month old female pt with a birth twin (sister) was vaccinated on 7/10/01 at 11 in the left thigh with the third dose of hep B vaccine (lot number 638721/0324L) (originally noted as being hep B vaccine), but changed to manufacturer not specified). Concomitant vaccinations on 7/10/01 included the third dose in the left thigh of ActHib (lot number UA577AA), the third dose in the right thigh of poliovirus vaccine (lot number T0786), the second dose in the left thigh Tripedia (lot number U0503AA) and the third dose in the right thigh of Prevnar (lot number 479233). At 14: 30 on 7/10/01 the pt experienced seizure activity, and had a temperature of 100 degrees F and some coughing. The pt presented to the ER that same day and was hospitalized. An EEG and a chest X-ray were performed. The chest x-ray showed Peri-hylar Bronchial Inflammatory Disease, and the EEg was borderline abnormal. A repeat EEG was normal, as was MRI results. Additional info ws received from a telephone call to a physician's office. A nurse explained that the pt recovered from the initial adverse events, but subsequently died on 4/15/02. Conflicting info regarding the date of the pt's death was received from a forensic pathologist, who indicated that the pt died within the first year of life. It was reported that the pt's twin sister also developed a seizure disorder and died after receiving hep B vaccine (lot number 638721/0324L) (manuf not specified) (WAES0209USA00458). Follow-up correspondence received on 8/9/02 from VAERS ID 173767 confirmed that VAERS received the autopsy report for both twins. The following autopsy (case :2002-1358, date 4/17/02) findings were provided by a medical examiner: cause of death: seizure disorder; manner of death: natural. The following pathological findings were noted: history of seizure disorder; hypoxic ischemic encephalopathy; cerebral edema, marked; tissue culture: no growth; and viral culture: negative. The pathological diagnosis was as follows: acute, global hypoxic/ischemic neuronal damage; diffuse, severe cerebral edema. The following findings were noted in the microscopic report: heart: the myocardium had no evidence of myocarditis or pericarditis; lungs: subpleural emphysema alternating with acelectasis: basement membrane is thin and delicate, peribronchial smooth muscle is not hypertrophied; kidney: acute congestion, the glomeruli are norocellular and collecting ducts are unremarkable; thyroid gland: normal appearing follicles and colloid were observed, no inflammation was observed; adrenal gland: normal appearing cortex and medulla free of hemorrhage; spleen: acute congestion and adequate periarteriolar lymphocytic aggregates, no acute inflammation observed. It was reported in the microscopic evaluation that nearly all neurons contained within sections of gray matter showed eosinophile degeneration. White matter vacuolation was seen in all sections. It was noted that no toxicology analysis was performed. No further info is expected. This was originally reported by a health care professional.