Age: 52.0
Sex: M
Vaccine: COVID19, COVID19
Symptoms: Migraine
Clinical narrative: Soon after receiving the first dose, patient started having frequent migraines/significant-sudden change in the pattern and severity of his headaches.; This spontaneous case was reported by a patient and describes the occurrence of MIGRAINE (Soon after receiving the first dose, patient started having frequent migraines/significant-sudden change in the pattern and severity of his headaches.) in a 52-year-old male patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 030A21A and 031B21A) for COVID-19 prophylaxis.     Concurrent medical conditions included Headache (Patient would experience 1 to not more than 4 headaches per month before vaccination.). Concomitant products included CAFFEINE, PARACETAMOL (EXCEDRIN [CAFFEINE;PARACETAMOL]) for Headache.   On 12-Mar-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 09-Apr-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. In 2021, the patient experienced MIGRAINE (Soon after receiving the first dose, patient started having frequent migraines/significant-sudden change in the pattern and severity of his headaches.). The patient was treated with GABAPENTIN at a dose of 600 milligram once a day; GABAPENTIN at a dose of 300 milligram and RIZATRIPTAN at a dose of 10 milligram. At the time of the report, MIGRAINE (Soon after receiving the first dose, patient started having frequent migraines/significant-sudden change in the pattern and severity of his headaches.) had not resolved.        For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown), the reporter considered MIGRAINE (Soon after receiving the first dose, patient started having frequent migraines/significant-sudden change in the pattern and severity of his headaches.) to be related.    Patient hadn't received any other vaccines in the 4 weeks prior to COVID-19 vaccine. It was reported that after dose 1, patient experienced a very significant change in both frequency and intensity of headaches. Prior to Moderna Covid vaccination, patient would experience 1 to no more than 4 headaches per month that were always easily resolved with over-the-counter medication Excedrin (two Extra Strength tablets). After the second dose of Moderna vaccination,  Patient began to experience 8 to 12 headaches per month of extreme intensity and over-the-counter  Excedrin was not effective. After 3-6 months of trying to figure out how to manage this sudden  change in headache behavior, patient consulted a neurologist in early 2021 about therapies to manage the headaches. First a full head MRI was ordered to confirm that there were no issues that could explain this sudden change in headaches. Then patient was referred to a sleep specialist, who ordered an at-home sleep study. The sleep specialist confirmed that patient didn't had sleep issues, such as sleep apnea, that would explain this sudden change in headaches.  In the beginning, patient was taking a daily 600mg dose of Gabapentin. This had a dramatic effect in reducing the frequency of headaches to no more than 1 per month. After several months patient discussed reducing the dosage with the neurologist. The current course of treatment for managing headaches the past 6 months had been a daily 300mg dose of Gabapentin. At the onset of a headache patient would typically try Excedrin Extra strength first, if that was not effective patient would take 10 mg Rizatriptan tablet for severe headaches. At the time of report patient was experiencing fewer than four headaches per month. Patient believed that the Moderna Covid vaccine was associated with the change in headache frequency and intensity that patient had experienced.   This case was linked to MOD-2023-724597 (Patient Link).   Most recent FOLLOW-UP information incorporated above includes: On 05-Jun-2023: Follow-up received, updated patient medical history, treatment drug information, event verbatim, reporter causality and I narrative.