Age: 48.0
Sex: M
Vaccine: COVID19
Symptoms: Connective tissue disorder
Clinical narrative: The patient explained, the problem is I'm literally losing all the connective tissues and stuff that makes my arm round. It's all over my body, my shoulder, and it's on my right leg. It's going to the other side of my body; This spontaneous case was reported by a patient and describes the occurrence of CONNECTIVE TISSUE DISORDER (The patient explained, the problem is I'm literally losing all the connective tissues and stuff that makes my arm round. It's all over my body, my shoulder, and it's on my right leg. It's going to the other side of my body) in a 48-year-old male patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 033F21A, 026B21A and 002C21A) for COVID-19 prophylaxis.     No Medical History information was reported.   On 29-Mar-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 26-Apr-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 16-Nov-2021, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On an unknown date, the patient experienced CONNECTIVE TISSUE DISORDER (The patient explained, the problem is I'm literally losing all the connective tissues and stuff that makes my arm round. It's all over my body, my shoulder, and it's on my right leg. It's going to the other side of my body) (seriousness criterion medically significant). At the time of the report, CONNECTIVE TISSUE DISORDER (The patient explained, the problem is I'm literally losing all the connective tissues and stuff that makes my arm round. It's all over my body, my shoulder, and it's on my right leg. It's going to the other side of my body) had not resolved.        For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown), the reporter did not provide any causality assessments.   The concomitant medication was not reported by reporter. The patient stated that a couple of months after that it started with him eating at the table and he would rest his wrist on the table and could feel bones in his wrist, he saw veins in forearm. Patient stated that he received the initial doses in 2021, but believes it is from the Moderna Booster he received 16-Nov-2021. It started with him being able to feel bones that he couldn't feel before because there was protection. All the protective tissue that covers his muscle was gone. He can saw bone and vein and there was no fat over it. It was moving all over his body. He was down to like his bone in the middle of my right forearm. He started being able to feel bones in his right arm that he could never felt before, the bones were sticking out. Something within him was eating his fat. Patient stated, he can feel bones in his arms, and all connective tissues in gone, his arm was no longer round, his right shoulder was like a cage. His right chest, to his shoulder was like a cage and you can rest your hand in there. This thing was relentlessly keeping on going. His right leg was duplicating the same symptoms as his right arm. His right thigh also was starting to dimple in both sides of his leg. Patient was totally healthy and in the best shape of his life, He lost some strength right side, and lost tissue. Patient stated, he could print probably 200 pages of different tests. He had taken. Patient had every blood test under the sun, Lyme-disease, Lupus like anything and everything. He was not going to lie. Rheumatologist, neurologist, and Cancer doctor and they just look at his at this and don't know what he had; he had been literally lost half of the right arm. He was running out of time. He watched his body eat itself for a year and a half. The patient stated that he's had the Pfizer in 26-Sep-2022- Pfizer, GH9693, but all the problems were already on him like.  Company comment: This spontaneous case concerns a 48  year  old male patient, with no medical history reported, who received three doses of Moderna COVID-19 Vaccine (mRNA  1273) and experienced the unexpected, serious (medically significant) event of connective tissue disorder. Latency cannot be properly assessed since exact onset date was not provided. The report stated that months after receiving the booster vaccine he "has been losing body tissue all over his body". Rheumatologist, Neurologist, and Cancer doctors were consulted and "200 pages of different laboratory tests" were performed, included for Lupus like syndrome or Lyme disease; however, no diagnosis was provided. The patient explained that his problem is that he is "losing all the connective tissues It's all over the body". The outcome of the event was not recovered. No further clinical details were provided for medical reviewing. The Benefit-risk relationship of Moderna COVID-19 Vaccine (mRNA  1273) is not affected by this report.