Sex: M
Vaccine: COVID19
Symptoms: Investigation, Laboratory test, Laboratory test abnormal, Mental status changes, Mydriasis
Clinical narrative: acute kidney injury; acute respiratory failure; blood creatinine increased; blood sodium increased; body temperature increased; cardiac arrest; confustional state; Embolism venous; hypernatramia; hypophagia; laboratory test abnormal; mental status change; mydriasis; pulse absent; pupil fixed; respiratory arrest; staphylococcal bacteraemia; troponin increased; unresponsive to stimuli; white blood cell count increased; This is a spontaneous report received from a non-contactable reporter(s) (Consumer or other non HCP).  A 79-year-old male patient received BNT162b2 (BNT162B2), as dose 3 (booster), single (Lot number: FF2593) for covid-19 immunisation.  The patient's relevant medical history included: "Dementia" (unspecified if ongoing), notes: Patient has advanced dementia, not conversational at baseline. The patient's concomitant medications were not reported. Vaccination history included: Covid-19 vaccine moderna (Dose: 1, COVID-19 Vaccine, Vaccine: COVID-19 (COVID-19 Moderna)), Manufacturer: Moderna, Lot: 006M20A), for COVID-19 Immunization; Covid-19 vaccine moderna (Dose: 2, COVID-19 Vaccine, Vaccine: COVID-19 (COVID-19 Moderna)), Manufacturer: Moderna, Lot: 040A21A), for COVID-19 Immunization. The following information was reported: EMBOLISM VENOUS (death, hospitalization, medically significant) with onset 23Aug2022, outcome "fatal"; ACUTE KIDNEY INJURY (death, hospitalization, medically significant) with onset 23Aug2022, outcome "fatal"; ACUTE RESPIRATORY FAILURE (death, hospitalization, medically significant) with onset 23Aug2022, outcome "fatal"; BLOOD CREATININE INCREASED (death, hospitalization, medically significant) with onset 23Aug2022, outcome "fatal"; BLOOD SODIUM INCREASED (death, hospitalization, medically significant) with onset 23Aug2022, outcome "fatal"; BODY TEMPERATURE INCREASED (death, hospitalization, medically significant) with onset 23Aug2022, outcome "fatal"; CARDIAC ARREST (death, hospitalization, medically significant) with onset 23Aug2022, outcome "fatal"; CONFUSIONAL STATE (death, hospitalization, medically significant) with onset 23Aug2022, outcome "fatal", described as "confustional state"; HYPERNATRAEMIA (death, hospitalization, medically significant) with onset 23Aug2022, outcome "fatal", described as "hypernatramia"; HYPOPHAGIA (death, hospitalization, medically significant) with onset 23Aug2022, outcome "fatal"; LABORATORY TEST ABNORMAL (death, hospitalization, medically significant) with onset 23Aug2022, outcome "fatal"; MENTAL STATUS CHANGES (death, hospitalization, medically significant) with onset 23Aug2022, outcome "fatal", described as "mental status change"; MYDRIASIS (death, hospitalization, medically significant) with onset 23Aug2022, outcome "fatal"; PULSE ABSENT (death, hospitalization, medically significant) with onset 23Aug2022, outcome "fatal"; PUPIL FIXED (death, hospitalization, medically significant) with onset 23Aug2022, outcome "fatal"; RESPIRATORY ARREST (death, hospitalization, medically significant) with onset 23Aug2022, outcome "fatal"; STAPHYLOCOCCAL BACTERAEMIA (death, hospitalization, medically significant) with onset 23Aug2022, outcome "fatal"; TROPONIN INCREASED (death, hospitalization, medically significant) with onset 23Aug2022, outcome "fatal"; UNRESPONSIVE TO STIMULI (death, hospitalization, medically significant) with onset 23Aug2022, outcome "fatal"; WHITE BLOOD CELL COUNT INCREASED (death, hospitalization, medically significant) with onset 23Aug2022, outcome "fatal". The patient was hospitalized for acute kidney injury, acute respiratory failure, blood creatinine increased, blood sodium increased, body temperature increased, cardiac arrest, confusional state, embolism venous, hypernatraemia, hypophagia, laboratory test abnormal, mental status changes, mydriasis, pulse absent, pupil fixed, respiratory arrest, staphylococcal bacteraemia, troponin increased, unresponsive to stimuli, white blood cell count increased (hospitalization duration: 7 day(s)). The patient underwent the following laboratory tests and procedures: Blood creatinine: (2022) 3.07; Blood pressure measurement: (2022) 168/104; Blood sodium: (2022) 162; Body temperature: (2022) 102 Fahrenheit; Heart rate: (2022) 134; Laboratory Test: (2022) Abnormal; MSSA bacteremia: (2022) MSSA bacteremia; Oxygen saturation: (2022) 89 %; Oxygen therapy: (2022) 6 L; Respiratory rate: (2022) 36; SARS-CoV-2 test positive: (23Aug2022) Detected, notes: SARS-COV-2 (COVID-19) by NAA MIcro; Troponin: (2022) 0.11; White blood cell count: (2022) 19.6. The patient date of death was 31Aug2022. Reported cause of death: "acute kidney injury", "acute respiratory failure", "blood creatinine increased", "blood sodium increased", "body temperature increased", "cardiac arrest", "confustional state", "Embolism venous", "hypernatramia", "hypophagia", "laboratory test abnormal", "mental status change", "mydriasis", "pulse absent", "pupil fixed", "respiratory arrest", "staphylococcal bacteraemia", "troponin increased", "unresponsive to stimuli", "white blood cell count increased". It was not reported if an autopsy was performed.  Additional information: Patient presented with altered mental status. Patient was a poor withheld; majority of history was taken from wife over the phone. Patient tested positive for COVID on 12Aug2022 at his nursing home. Patient has advanced dementia, not conversational at baseline. He was living with his wife at home until 01Aug2022 when he moved into a nursing home. A few weeks ago, he started having poor oral intake and worsening confusion. In the EC, temp 102 degF, blood pressure 168/104, heart rate 134, respiratory rate 36, pulse ox 89% on 6L nasal canula. Labs significant for sodium 162, creatinine 3.07, troponin 0.11, WBC 19.6. COVID test positive. Patient found to be in acute hypoxic respiratory failure due to COVID, MSSA bacteremia, VTE, AKI and hypernatremia. Family including wife and daughter, decided to transition patient to hospice care. Patient assessed and unresponsive to verbal and tactile stimuli, pulseless, respirations and heart sounds absent. Pupils dilated, fixed, and unresponsive to light. Date and time of death pronounced on 31Aug2022 at 16:00.  No follow-up attempts are possible. No further information is expected.; Reported Cause(s) of Death: respiratory arrest; acute kidney injury; acute respiratory failure; blood creatinine increased; blood sodium increased; body temperature increased; cardiac arrest; confustional state; Embolism venous; hypernatramia; hypophagia; laboratory test abnorm