Age: 70.0
Sex: F
Vaccine: COVID19, COVID19
Symptoms: Musculoskeletal chest pain, Pigmentation disorder, Vaccination site erythema
Clinical narrative: Possible glaucoma/ white patches were seen on nerve of eye/white spot around left and right eye nerves; Found a black spot on left breast; Was woken up by hurt and severe pain on the left side of breast about 2 inches from nipple; Sharp chest pain "like nerve pain"; Severe pain in right eye which lasted approximately 2 seconds; Red spot at left arm injection site/ approximate 4 inch long oval red spot; Red pimples and spots spread on whole face; Pain at ribs/Severe pain under my right ribs in the diaphgram area; Red pimples; Swollen liver/swollen liver gets smaller and smaller; Liver pain; This case was initially received via an unknown source (no reference has been entered for a health authority or license partner) on 09-Dec-2021. The most recent information was received on 22-Jan-2022 and was forwarded to Moderna on 22-Jan-2022.    This spontaneous case was reported by a consumer and describes the occurrence of CHEST PAIN (Sharp chest pain "like nerve pain") and GLAUCOMA (Possible glaucoma/ white patches were seen on nerve of eye/white spot around left and right eye nerves) in a 70-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 048A21A and 024M20A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     Concurrent medical conditions included Hyperthyroidism since 02-Aug-2007, Osteopenia since 19-Nov-2010, Latent tetany since 14-Aug-2012, Magnesium deficiency since 14-Aug-2012, Age-related macular degeneration since 29-Apr-2017, Hypertension since 07-Jul-2019, Allergy to antibiotic, Allergy to antibiotic, Allergy to antibiotic and Fruit allergy (Tomato allergy in childhood). Concomitant products included FISH OIL (OMEGA 3 FISH OILS) and RESVEGA for Age-related macular degeneration, RAMIPRIL for Hypertension, LEVOTHYROXINE for Hyperthyroidism, MAGNESIUM ASPARTATE, PYRIDOXINE HYDROCHLORIDE (LAKTOMAG B6 [MAGNESIUM ASPARTATE;PYRIDOXINE HYDROCHLORIDE]) for Latent tetany, CALCIUM for Osteopenia, MULTIVITAMIN [VITAMINS NOS] for an unknown indication.   On 16-Feb-2021 at 9:30 AM, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 16-Mar-2021 at 9:30 AM, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 16-Mar-2021, the patient experienced LIVER DISORDER (Swollen liver/swollen liver gets smaller and smaller), HEPATIC PAIN (Liver pain) and MUSCULOSKELETAL CHEST PAIN (Pain at ribs/Severe pain under my right ribs in the diaphgram area). 16-Mar-2021, the patient experienced PIGMENTATION DISORDER (Red pimples and spots spread on whole face). 16-Mar-2021, the patient experienced ACNE (Red pimples). On 18-Mar-2021, the patient experienced VACCINATION SITE ERYTHEMA (Red spot at left arm injection site/ approximate 4 inch long oval red spot). On 05-Apr-2021, the patient experienced CHEST PAIN (Sharp chest pain "like nerve pain") (seriousness criterion medically significant) and BREAST PAIN (Was woken up by hurt and severe pain on the left side of breast about 2 inches from nipple). In April 2021, the patient experienced EYE PAIN (Severe pain in right eye which lasted approximately 2 seconds). On 12-Jun-2021, the patient experienced BREAST DISORDER (Found a black spot on left breast). On 15-Jul-2021, the patient experienced GLAUCOMA (Possible glaucoma/ white patches were seen on nerve of eye/white spot around left and right eye nerves) (seriousness criterion medically significant). In April 2021, LIVER DISORDER (Swollen liver/swollen liver gets smaller and smaller) and EYE PAIN (Severe pain in right eye which lasted approximately 2 seconds) had resolved. At the time of the report, CHEST PAIN (Sharp chest pain "like nerve pain"), GLAUCOMA (Possible glaucoma/ white patches were seen on nerve of eye/white spot around left and right eye nerves), BREAST PAIN (Was woken up by hurt and severe pain on the left side of breast about 2 inches from nipple), PIGMENTATION DISORDER (Red pimples and spots spread on whole face), MUSCULOSKELETAL CHEST PAIN (Pain at ribs/Severe pain under my right ribs in the diaphgram area), BREAST DISORDER (Found a black spot on left breast), ACNE (Red pimples) and VACCINATION SITE ERYTHEMA (Red spot at left arm injection site/ approximate 4 inch long oval red spot) outcome was unknown and HEPATIC PAIN (Liver pain) was resolving.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On 12-Jun-2021, Mammogram: abnormal (abnormal) revealed black spots where she felt the sharp pain that were benign. In September 2021, Antibody test: positive (Positive) have antibodies.         No treatment medication information provided. Patient started levothyroxine on 8-Nov, Calcium on 19-Nov, lactomag b6 on 14-Aug, Ramipril on 27-Jul, Omega 3 , Thelo2 3% and resvega on 29-Apr however year of starting was unclear. Patient reported that when she touched the area of pain she felt thick liquid and pain was strong for a whole day. Pain in here left breast was in semicircle shape. It was reported that her heart condition was fine.The mammogram ruled the spots as benign and not cancerous. Within the next 3 to 4 weeks the pain and feelings of swollen liver gradually disappeared. Also she reported that she sleeps on one side due to strong pain and pain was reduced next morning. Company comment This case concerns a 70-year-old female patient, with medical history of Hypertension reported, who experienced the unexpected serious events of CHEST PAIN and GLAUCOMA. The event CHEST PAIN occurred approximately 1 month 20 days  after the administration of the second dose of mRNA-1273 vaccine. Event GLAUCOMA occurred approximately 5 months after the administration of the second dose of mRNA-1273 vaccine. At the time of report event LIVER DISORDER and EYE PAIN had resolved, hepatic pain was resolving rest of events outcome is unknown. On 12-Jun-2021, Mammogram: abnormal revealed black spots where she felt the sharp pain that were benign .In September 2021, Antibody test was  positive . The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report.    This case was linked to MOD-2022-459666 (Patient Link).   Most recent FOLLOW-UP information incorporated above includes: On 22-Jan-2022: Follow-up information and patient demographics, medical history,concomitant medication and new events were added.; Sender's Comments: This case concerns a 70-year-old female patient, with medical history of Hypertension reported, who experienced the unexpected serious events of CHEST PAIN and GLAUCOMA. The event CHEST PAIN occurred approximately 1 month 20 days  after the administration of the second dose of mRNA-1273 vaccine. Event GLAUCOMA occurred approximately 5 months after the administration of the second dose of mRNA-1273 vaccine. At the time of report event LIVER DISORDER and EYE PAIN had resolved, hepatic pain was resolving rest of events outcome is unknown. On 12-Jun-2021, Mammogram: abnormal revealed black spots where she felt the sharp pain that were benign .In September 2021, Antibody test was  positive . The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report.