Age: 24.0
Sex: M
Vaccine: COVID19, COVID19
Symptoms: Investigation, Loss of consciousness, Myocarditis, Pericarditis, Presyncope
Clinical narrative: presyncopal episode; Chest tightness/ chest discomfort/ left sided chest squeezing; The pain was worse with inspiration and lying down and improved with sitting forward and standing up.; Myocarditis; Endocarditis; feeling lightheaded; weak; had visual disturbances; loss of consciousness (LOC); diagnosed with pericarditis; serial elevated troponins; elevated CRP; nonspecific EKG changes; This is a spontaneous report from a contactable consumer (patient's mother; an other HCP reporting for her son) and a pharmacist. A 24-year-old male patient received the second dose of BNT162B2 (PFIZER BIONTECH COVID-19 VACCINE) via an unspecified route of administration, administered in the upper right arm on 14Sep2021 (batch/lot number: FF2588) at the age of 24 years old, as DOSE 2, SINGLE for COVID-19 immunization and to follow safety guidelines. The vaccine was administered at a pharmacy/drug store vaccination facility. The patient had no history of COVID-19 prior to vaccination. He was a healthy 24-year-old male until he got the vaccine. Patient was fully vaccinated with the standard childhood and adult vaccines and had no reactions from them. Patient had no known allergies. There were no concomitant medications. There were no prior vaccinations within 4 weeks and no other medications in two weeks. The patient previously received the first dose of BNT162B2 (PFIZER BIONTECH COVID-19 VACCINE) via an unspecified route of administration on 24Aug2021 (batch/lot number: FC3182) at the age of 24 years old, as DOSE 1, SINGLE for COVID-19 immunization and to follow-safety guidelines. The patient experienced serial elevated troponins, elevated CRP, nonspecific EKG changes, and pericarditis on Sep2021; feeling lightheaded, weak, had visual disturbances, loss of consciousness (LOC)  on 14Sep2021; experienced "chest tightness/ chest discomfort/ left sided chest squeezing" (chest tightness), "pain was worse with inspiration and lying down and improved with sitting forward and standing up" (chest pain), myocarditis, and endocarditis on 16Sep2021; and presyncopal episode on 17Sep2021. The patient was hospitalized for chest tightness and presyncopal episode from 17Sep2021 to an unknown date for 5 days. The mother reported that her son got the second dose on 14Sep2021 and two days later he had chest tightness which required a visit to the Emergency Room and Physician Office. Patient went to Urgent Care and was hospitalized with everything they said would happen. The patient was diagnosed with Endocarditis and Myocarditis on 16Sep2021. The mother reported that chest tightness started Thursday night 16Sep2021). She did not know what time it started, but it was in the PM. Her son went to Urgent Care on Friday (17Sep2021) and from there went to Emergency Room and then was admitted to the hospital. Last night (date not reported), he was transported to another hospital for another test to be done that was not available at that hospital. Clinical intervention was unknown. The patient was diagnosed with the endocarditis and myocarditis while in the hospital; the hospitalist diagnosed her son with endocarditis and the cardiologist came in and also diagnosed her son with pericarditis yesterday (Sep2021). The patient had a lot of labs and testing done every day, blood work, cardiac work up, results were not reported. The patient's mother stated that this information would be better provided by the medical professionals. The pharmacist further reported that the patient presented to hospital after experiencing chest discomfort and presyncopal episode on 17Sep2021 at an urgent care. The patient received his second COVID-19 vaccine on 14Sep2021. Immediately following the vaccine, he stood up to shop. While walking in the aisle, he began feeling lightheaded, weak, and had visual disturbances. He was able to sit down in a chair but had loss of consciousness (LOC) while in chair. He went home after. He laid in bed on the evening of 16Sep2021 and began feeling a left sided chest squeezing rated 6/10 radiating up into his neck. The pain was worse with inspiration and lying down and improved with sitting forward and standing up. He attempted to go to work the following morning on 17Sep2021 where he works in surveying and worked primarily outside but was sent to urgent care by his boss. His work up at Privacy on an unknown date in Sep2021 was remarkable for serial elevated troponins, elevated CRP, and nonspecific EKG changes. Patient was diagnosed with myocarditis on 16Sep2021. Therapeutic measures were taken as a result of the events which included Aspirin 325 mg daily and metoprolol tartate 12.5 mg BID. The patient recovered from loss of consciousness on an unknown date. Outcome of the events endocarditis and pericarditis was unknown. Outcome of the other events was recovering. The patient tested negative for SARS-CoV-2 test on 17Sep2021.; Sender's Comments: Based on the information in the case report, a possible causal association between the events decreased and suspect drug BNT162B2 cannot be excluded. The impact of this report on the benefit/risk profile of the Pfizer product is evaluated as part of Pfizer procedures for safety evaluation, including the review and analysis of aggregate data for adverse events. Any safety concern identified as part of this review, as well as any appropriate action in response, will be promptly notified to regulatory authorities, Ethics Committees, and Investigators, as appropriate.