Age: 0.7
Sex: F
Vaccine: PNC
Symptoms: Apnoea, Convulsion, Hypotonia, Laboratory test abnormal, Pyrexia
Clinical narrative: A physician reported that an 8 month old female received her third dose of Prevnar on 6/23/03. The infant has no relevant medical history. That same evening, the infant developed a tactile low grade fever. On 6/24/03, the infant experienced seizures, atonia with apnea, and some seizures that were convulsions, and was hospitalized. Treatment medications included IV Dilantin, phenobarbital, and Ativan. On 6/25/03, the infant was discharged without medications. On 6/26/03, she experienced more seizures and was again hospitalized. She was treated with 2 doses of Ativan (one oral and one IV), then with IV Dilantin and phenobarbital. As of 6/27/03, the infant remained in the hospital and was receiving IV phenobarbital. The physician stated that no adverse events occurred following receipt of the first two doses of Prevnar. No further information was available at the date of this report. Additional info received on 7/14/03 from the pt's pediatrician indicated that on 6/24/03, the infant was taken to an emergency room via ambulance after experiencing a seizure. She was admitted to the hospital where she experienced three more tonic-clonic seizures. Her temperature on admission was 98.3 deg F. A CT scan of the head was performed; the results were negative. Treatment medications included Tegretol and Dilantin. Several days after admission, the infant became "apnic with loss of tone." She was intubated and transferred to another hospital facility. She was discharged on an unspecified date. Discharge medications included Tegretol and Dilantin. No further info was available at the date of this report.  A 15-day follow up report received 8/12/2003 adds: Follow-up info received from the neurologist on 07/10/2003 provided additional hospitalization details (pt admitted to PICU); laboratory test results; and stated that the pt was discharged without medications. A neurologist reported that an 8-month-old female with no significant medical history received her 3rd dose of Prevnar on 06/23/2003. That same evening, the infant developed a "tactile low grade fever." On 06/24/2003, the infant experienced "seizures, atonia with apnea, and some seizures that were convulsions" and was hospitalized. The seizures were later described as generalized tonic-clonic seizures. Treatment medications included intravenous Dilantin (phenytoin), phenobarbital, and Ativan (lorazepam). On 06/25/2003, the infant was discharged without medications. On 06/26/2003, she experienced more seizures and was again hospitalized. The infant was intubated and admitted to the PICU. She was treated with 2 doses of Ativan (one oral and one intravenous), then with intravenous Dilantin and phenobarbital. An EEG performed on 06/28/2003 revealed a probable seizure focus in the frontal lobe. An MRI and lumbar puncture (with CSF panel and lactate level) were performed on 06/30/2003; the results were normal. A CSF culture grew one colony of staph species which was "most likely" a contaminant. She seized a few times while in the hospital; therefore, her medication doses were increased, and she was started on Tegretol (carbamazepine). On 07/02/2003, the infant was discharged in "good" condition. The infant was weaned off the Tegretol and phenobarbital prior to being discharged. The neurologist indicated that the infant has had no further seizures. The neurologist noted that no adverse events occurred following receipt of the infant's first 2 doses of Prevnar. Additional info received on 07/14/2003 from the pt's pediatrician indicated that on 06/24/2003 the infant was taken to an ER via ambulance after experiencing a seizure. She was admitted to the hospital, where she experienced 3 more tonic-clonic seizures. Her temperature on admission was 98.3 deg. F. A CT scan of the head was performed; the results were negative. Treatment medications included Tegretol (carbamazepine) and Dilantin (phenytoin). Several days after admission, the infant became "apnic with loss of tone". She was intubated and transferred to another hospital facility. She was discharged on Tegretol and Dilantin.