Age: 76.0
Sex: M
Vaccine: RSV
Symptoms: Immediate post-injection reaction, Inflammation, Influenza like illness, Malaise, Mobility decreased
Clinical narrative: sick with the inflammation; sick with the inflammation; stiffness; thought I might have had Flu; reference range for the CRP was 0 to 10 and my rate was 255.8 (Later clarified 265.8); ESR reference range was 0 to 15 and mine was 61.; Difficulty in movement; I could not lift my arms above my head; Fever; Diarrhea; Fatigue; Sleepiness; Joint pain; muscle pain; This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP). The reporter is the patient.  A 76-year-old male patient received rsv vaccine prot.subunit pref 2v (ABRYSVO), on 11Sep2023 as dose number unknown, single (Batch/Lot number: unknown, Expiration Date: 10Sep2024) at the age of 76 years, in right deltoid for immunisation; for immunisation. The patient's relevant medical history included: "Allergy" (unspecified if ongoing), notes: Allergy; "cholesterol" (unspecified if ongoing), notes: take Atorvastatin which is for heart, I think for cholesterol, control Cholesterol. Concomitant medication(s) included: AZELASTINE taken for hypersensitivity; IPRATROPIUM BROMIDE taken for hypersensitivity; ATORVASTATIN taken for blood cholesterol. Vaccination history included: Covid-19 vaccine, administration date: May2023, when the patient was 75 years old, for Immunization. The following information was reported: DIARRHOEA (non-serious) with onset 11Sep2023, outcome "unknown", described as "Diarrhea"; FATIGUE (non-serious) with onset 11Sep2023, outcome "unknown"; ARTHRALGIA (non-serious) with onset 11Sep2023, outcome "unknown", described as "Joint pain"; SOMNOLENCE (non-serious) with onset 11Sep2023, outcome "unknown", described as "Sleepiness"; MYALGIA (non-serious) with onset 11Sep2023, outcome "not recovered", described as "muscle pain"; MOBILITY DECREASED (non-serious) with onset 09Oct2023, outcome "unknown", described as "Difficulty in movement; I could not lift my arms above my head"; PYREXIA (non-serious) with onset 09Oct2023, outcome "unknown", described as "Fever"; RED BLOOD CELL SEDIMENTATION RATE INCREASED (medically significant) with onset 24Oct2023, outcome "unknown", described as "ESR reference range was 0 to 15 and mine was 61."; C-REACTIVE PROTEIN INCREASED (medically significant) with onset 24Oct2023, outcome "unknown", described as "reference range for the CRP was 0 to 10 and my rate was 255.8 (Later clarified 265.8)"; ILLNESS (non-serious), INFLAMMATION (non-serious), outcome "unknown" and all described as "sick with the inflammation"; MUSCULOSKELETAL STIFFNESS (non-serious), outcome "not recovered", described as "stiffness"; INFLUENZA (non-serious), outcome "unknown", described as "thought I might have had Flu". The patient underwent the following laboratory tests and procedures: Body temperature: (unspecified date) back up to 102; C-reactive protein (0-10): (24Oct2023) 265.8, notes: my rate was 255.8 (Later clarified 265.8); Red blood cell sedimentation rate (0-15): (24Oct2023) 61; SARS-CoV-2 test: (24Oct2023) Negative; Weight: (unspecified date) maybe 195 to 200 pounds. Therapeutic measures were taken as a result of c-reactive protein increased, red blood cell sedimentation rate increased, arthralgia, myalgia, pyrexia, musculoskeletal stiffness, influenza.  Clinical course:  The patient went and had an inoculation, he got the Pfizer RSV shot (Clarified as Abrysvo) on 11Sep2023 and had some effects that his doctor should have told him all about so that was why he called. Immediately after the shot he had a little bit of diarrhea, little fatigue, sleepiness, some joint, muscle pain and that seem to not getting any worse and then on 09Oct2023, he had an onset of severe joint and muscle pain, difficulty in movement and onset of fever so I took a Covid test couple days apart, they were negative and when he got in touch with my doctor, they talked about it, he thought he might have had Flu and so he gave him some pills for flu and that did not help. Name of medication consumed for the treatment of flu was unknown. Then in order to control his fever, he found that he needed to take 2000 milligram of Tylenol plus 600 milligram of Ibuprofen, 6 times a day and that tend to reduce the fever some, but then it would go back up to 102 and so eventually, he called his doctor, made an appointment on 23Oct2023, had blood tests on 24Oct2023 and results on 25Oct2023 and 26Oct2023. It turns out, they did about 20 tests for things like Tick Borne diseases and the two that really stood out were results of inflammation C-reactive protein (CRP) test, ESR (Erythrocyte sedimentation rate), these were extremely high. The reference range for the CRP was 0 to 10 and my rate was 255.8 (Later clarified 265.8) and the ESR reference range was 0 to 15 and his  was 61. So, his doctor, after looking at all that stuff, he put him on Prednisone and told him, he should let you the physician knows. Patient had been on Prednisone since 28Oct2023, so he was about day 6 or 7 into the 10 day regimen of it and Prednisone immediately seemed to reduce the inflammation and he have not had to take the Tylenol or the Ibuprofen. Now, it was for about first 3 or 4 days and then starting with day 5, the aches the muscle and joint aches started coming back. When he was really sick with the inflammation, he could not lift his arms above his head and that was, the prednisone he did not even feel the pain, he felt better than he had before he even got the shot, but then slowly he continued with the prednisone, the stiffness and muscle pain is back. So, he probably would get in touch with his doctor.  It was further mentioned that the patient still in the middle of it, he was not finished with it (Prednisone). It slowly started coming back and little bit worse instead.   The information on the batch/lot number for rsv vaccine prot.subunit pref 2v, rsv vaccine prot.subunit pref 2v  has been requested and will be submitted if and when received.