Age: 55.0
Sex: M
Vaccine: COVID19
Symptoms: Bronchitis, COVID-19 immunisation, Hypoaesthesia, Interchange of vaccine products, Thrombosis
Clinical narrative: Numbness in my legs and Feet; Acute/ Chronic Bronchitis; Blood Clots in my Legs; took Janssen COVID-19 Vaccines as my First and Second Shots in 2019 and 2020. Later I took Moderna COVID-19 Vaccine as a Booster; took Janssen COVID-19 Vaccines as my First and Second Shots in 2019 and 2020. Later I took Moderna COVID-19 Vaccine as a Booster; This spontaneous case was reported by a patient and describes the occurrence of HYPOAESTHESIA (Numbness in my legs and Feet), BRONCHITIS (Acute/ Chronic Bronchitis) and THROMBOSIS (Blood Clots in my Legs) in a 55-year-old male patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 prophylaxis. The occurrence of additional non-serious events is detailed below.     Previously administered products included for Product used for unknown indication: Janssen COVID-19 Vaccines (First shot) in 2019 and Janssen COVID-19 Vaccines (Second shot) in 2020. Past adverse reactions to the above products included No adverse event with Janssen COVID-19 Vaccines and Janssen COVID-19 Vaccines. Concurrent medical conditions included Hypertension (since he was 34 Years Old and on Medication).    In June 2021, the patient received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. In June 2021, the patient experienced INTERCHANGE OF VACCINE PRODUCTS (took Janssen COVID-19 Vaccines as my First and Second Shots in 2019 and 2020. Later I took Moderna COVID-19 Vaccine as a Booster) and COVID-19 IMMUNISATION (took Janssen COVID-19 Vaccines as my First and Second Shots in 2019 and 2020. Later I took Moderna COVID-19 Vaccine as a Booster). On 01-Nov-2022, the patient experienced HYPOAESTHESIA (Numbness in my legs and Feet) (seriousness criterion hospitalization), BRONCHITIS (Acute/ Chronic Bronchitis) (seriousness criterion hospitalization) and THROMBOSIS (Blood Clots in my Legs) (seriousness criteria hospitalization and medically significant). At the time of the report, HYPOAESTHESIA (Numbness in my legs and Feet), BRONCHITIS (Acute/ Chronic Bronchitis) and THROMBOSIS (Blood Clots in my Legs) had not resolved and INTERCHANGE OF VACCINE PRODUCTS (took Janssen COVID-19 Vaccines as my First and Second Shots in 2019 and 2020. Later I took Moderna COVID-19 Vaccine as a Booster) and COVID-19 IMMUNISATION (took Janssen COVID-19 Vaccines as my First and Second Shots in 2019 and 2020. Later I took Moderna COVID-19 Vaccine as a Booster) outcome was unknown.            Patient was on concomitant medication for hypertension. No treatment information was reported.  COMPANY COMMENT:  This is a spontaneous case concerning a 55-year-old male patient with medical history of Previously administered Janssen COVID-19 Vaccines (2 doses without adverse events) and hypertension who experienced the unexpected seriousness criteria medically significant and hospitalization unexpected AESI of thrombosis; the unexpected seriousness criteria hospitalization unexpected events of bronchitis and hypoaesthesia. The pateint reported experiencing symptoms approximately 6 months after 3rd. dose of mRNA-1273 vaccine. As reported, patient was hospitalized several times for difficulty in breathing and had hospitalization approx. 16 months after 3rd dose. As the patient received doses of Janssen vaccine; "interchange of vaccine products" and "revaccination with different Covid-19 vaccine" were noted in this case. The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report.