Sex: F
Vaccine: VARZOS
Symptoms: Guillain-Barre syndrome, Hypoaesthesia, Muscle spasms, Neuropathy peripheral, Pain in extremity
Clinical narrative: diagnosed with acute inflammatory demyelinating polyneuropathy (AIDP), on the spectrum of Guillame Barre; left with neuropathy in their feet; developed excruciating pain in my arms, hands, legs and feets; painful spasms in my feet; numbness on the bottom of my feet; This serious case was reported by a consumer and described the occurrence of demyelinating polyneuropathy in a 81-year-old female patient who received Herpes zoster (Shingrix) for prophylaxis.   On an unknown date, the patient received the 1st dose of Shingrix. On an unknown date, an unknown time after receiving Shingrix, the patient experienced demyelinating polyneuropathy (Verbatim: diagnosed with acute inflammatory demyelinating polyneuropathy (AIDP), on the spectrum of Guillame Barre) (serious criteria GSK medically significant), peripheral neuropathy (Verbatim: left with neuropathy in their feet) (serious criteria GSK medically significant), pain in extremity (Verbatim: developed excruciating pain in my arms, hands, legs and feets), spasms (Verbatim: painful spasms in my feet) and numbness in feet (Verbatim: numbness on the bottom of my feet). The patient was treated with gabapentin. The outcome of the demyelinating polyneuropathy, peripheral neuropathy and numbness in feet were not resolved and the outcome of the pain in extremity and spasms were resolved.   It was unknown if the reporter considered the demyelinating polyneuropathy, peripheral neuropathy, pain in extremity, spasms and numbness in feet to be related to Shingrix.     The company considered the demyelinating polyneuropathy and peripheral neuropathy to be unrelated to Shingrix. It was unknown if the company considered the pain in extremity, spasms and numbness in feet to be related to Shingrix.   Additional Information: GSK Receipt Date: 21-OCT-2024 The patient self-reported this case. The patient who was injured by the first of a series of 2 Shingrix shots in 2019, she never took the 2nd shot. Eight days after receiving that shot she developed excruciating pain in my arms, hands, legs and feet. Although being told by two physicians that the vaccine did not cause the pain, the neurology team diagnosed her condition as acute inflammatory demyelinating polyneuropathy(AIDP), on the spectrum of Guillame Barre. They treated her with gabapentin which relieved the pain. However, she was left with neuropathy in her feet which caused severe and painful spasms in her feet along with numbness on the bottom of her feet. After several weeks saw a neurologist, she asked her what could be done to help this situation, she said there was nothing. After the article she started using DMSO on the bottom of her feet and over the tops of her toes when she went to  bed. The first time she used it, she had no spasms which always happened at night when she was trying to go to sleep. She has now used it for 3 days and still no spasms. It look like a miracle. She would continue using it to see if it helps resolve the numbness in her feet. She never would have tried this without GSK articles and would have suffered needlessly forever. She owe GSK a great debt. She told everyone about DMSO and sending GSK articles as well.; Sender's Comments: Demyelinating polyneuropathy and Neuropathy peripheral are unlisted events which are considered unrelated to GSK vaccine Shingrix.