Age: 20.0
Sex: F
Vaccine: FLUX
Symptoms: Chills, Condition aggravated, Dizziness, Feeling cold, Headache
Clinical narrative: Almost passed out in the shower; Headache; Postural orthostatic tachycardia syndrome; Covered in sweat; Could not get warm no matter what I did; Condition aggravated; Nausea; Dizzy; Temperature was 102.5; Uncontrollable shivering; This spontaneous case was retrieved on 06-Dec-2021 from Vaccine Adverse Event Reporting System (VAERS) (reference number: 1768739-1), reported by other non-health professional (consumer) and concerned a 20-year-old, female patient.   The patient's concurrent conditions included postural orthostatic tachycardia syndrome (POTS) and allergy to amoxicillin. The patient's concomitant medication included ibuprofen and carvedilol, both used for unreported indication.   On 05-Oct-2021, the patient was vaccinated with influenza virus vaccine polyvalent (brand not specified; indication: not reported, dose reported as one, route of administration: intramuscular and anatomical location: left arm). The batch number was not reported.  On 05-Oct-2021 at 09:00 pm, after receiving influenza virus vaccine polyvalent, the patient woke up from a nap with uncontrollable shivering and nausea. She decided to take a bath since she could not get warm no matter what she did. When the patient went to get out of the bath, she was extremely dizzy. She took her temperature and it was 102.5. Also, the patient had headache. The patient noted that the vaccine for some reason really interfered with her POTS and that she typically didn't have reactions to vaccines at all.  On 06-Oct-2021, one day after receiving influenza virus vaccine polyvalent, the patient woke up covered in sweat and her temperature in the morning was 100.1. She felt better until she went to go shower and almost passed out in the shower. The whole morning her temperature was 99 then it finally normalized later in the day.  At the time of this initially reporting, the patient recovered from the events.  The events of postural orthostatic tachycardia syndrome and condition aggravated were assessed as related to the influenza virus vaccine polyvalent, since the patient reported that that the vaccine for some reason really interfered with her POTS and that she typically didn't have reactions to vaccines at all. The reporter did not provide a causality assessment for the other events.  This case was assessed as non-serious.  Company comment: A 20-year-old female patient experienced chills, felt cold, nausea, dizziness, pyrexia, headache, hyperhidrosis and presyncope within one day after receiving influenza virus vaccine polyvalent. The patient's concurrent conditions included postural orthostatic tachycardia syndrome (POTS). The patient's concomitant medication included Carvedilol. Causality for POTS is assessed as not related due to existance prior to vaccination. Since the patient's condition of POTS and her concomitant medication Carvedilol provide plausible alternative etiologies, causality for presyncope and condition aggravated is assessed as not related. Based on plausible temporal relationship, causality for the other events is assessed as possibly related.; Sender's Comments: A 20-year-old female patient experienced chills, felt cold, nausea, dizziness, pyrexia, headache, hyperhidrosis and presyncope within one day after receiving influenza virus vaccine polyvalent. The patient's concurrent conditions included postural orthostatic tachycardia syndrome (POTS). The patient's concomitant medication included Carvedilol. Causality for POTS is assessed as not related due to existance prior to vaccination. Since the patient's condition of POTS and her concomitant medication Carvedilol provide plausible alternative etiologies, causality for presyncope and condition aggravated is assessed as not related. Based on plausible temporal relationship, causality for the other events is assessed as possibly related.