Age: 47.0
Sex: M
Vaccine: COVID19-2, COVID19
Symptoms: Anti-thyroid antibody, Blood thyroid stimulating hormone, Electrocardiogram, Hyperthyroidism, Thyroxine
Clinical narrative: He reports that 2 days after Bivalent booster, he started loosing weight, was Tired, and had Rapid Heart Beat/diagnosed him with Hyperthyroidism; This spontaneous case was reported by a patient and describes the occurrence of HYPERTHYROIDISM (He reports that 2 days after Bivalent booster, he started loosing weight, was Tired, and had Rapid Heart Beat/diagnosed him with Hyperthyroidism) in a 47-year-old male patient who received mRNA-1273 BIVALENT .222 (MODERNA COVID-19 VACCINE, BIVALENT (ORIGINAL AND OMICRON BA.4/BA.5)) (batch no. 050D22A) for COVID-19 prophylaxis.     Patient does not have a family history of thyroid issues and his thyroid was working fine.     On 14-Oct-2022, the patient received fourth dose of mRNA-1273 BIVALENT .222 (MODERNA COVID-19 VACCINE, BIVALENT (ORIGINAL AND OMICRON BA.4/BA.5)) (Intramuscular) 1 dosage form. On an unknown date, the patient experienced HYPERTHYROIDISM (He reports that 2 days after Bivalent booster, he started loosing weight, was Tired, and had Rapid Heart Beat/diagnosed him with Hyperthyroidism) (seriousness criterion medically significant). The patient was treated with METHIMAZOLE for Hyperthyroidism, at an unspecified dose and frequency. At the time of the report, HYPERTHYROIDISM (He reports that 2 days after Bivalent booster, he started loosing weight, was Tired, and had Rapid Heart Beat/diagnosed him with Hyperthyroidism) had not resolved.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On 01-Nov-2022, Blood thyroid stimulating hormone: 0.008. On 07-Nov-2022, Blood thyroid stimulating hormone: 0.006. On 14-Nov-2022, Blood thyroid stimulating hormone: 0.005. On an unknown date, Anti-thyroid antibody: Thyroid Antibody : 32. On an unknown date, Blood thyroid stimulating hormone: The last annual exam TSH test was normal prior to vaccination.. On an unknown date, Electrocardiogram: EKG was normal.. On an unknown date, Thyroxine: The T3 & T4 were normal.. On an unknown date, Tri-iodothyronine: The T3 & T4 were normal..     For mRNA-1273 BIVALENT .222 (MODERNA COVID-19 VACCINE, BIVALENT (ORIGINAL AND OMICRON BA.4/BA.5)) (Intramuscular), the reporter did not provide any causality assessments.   No relevant concomitant medications were reported. Patient had dose 1 on 07 APR 2021 (Lot number- 040B21A), dose 2 on 07 May 2021 (Lot number- 014C21A) and dose 3 on 10 DEC 2021 (Lot number- 045J21A). After having experienced events, he visited an urgent care. He visited a doctor in another country also.  Company comment: This is a spontaneous case regarding a 47-year-old male patient who experienced unexpected and medically significant event of Hyperthyroidism (AESI) after receiving  mRNA-1273.222 bivalent vaccine (Original/Omicron BA.4/5), reported as the fourth dose of the COVID-19 vaccination schedule. According to the report, 2 days after receiving bivalent booster, patient started loosing weight, was tired, and had rapid heart beat. He visited an urgent care and was diagnosed with hyperthyroidism. Diagnostic test results inlcuded: normal EKG;  TSH : 0.008 (01-Nov-2022), 0.006 (07-Nov-2022) and 0.005 (14-Nov-2022); normal T3 & T4; and thyroid Antibody: 32. Treatment included Methimazole. Patient does not have a family history of thyroid dysorder and TSH test was normal prior to vaccination. No further details regarding clinical course, diagnostic tests or treatment performed were disclosed. The benefit-risk relationship of mRNA-1273.222 bivalent vaccine is not affected by this report.; Sender's Comments: This is a spontaneous case regarding a 47-year-old male patient who experienced unexpected and medically significant event of Hyperthyroidism (AESI) after receiving  mRNA-1273.222 bivalent vaccine (Original/Omicron BA.4/5), reported as the fourth dose of the COVID-19 vaccination schedule. According to the report, 2 days after receiving bivalent booster, patient started loosing weight, was tired, and had rapid heart Beat. He visited an urgent care and was diagnosed with hyperthyroidism. Diagnostic test results inlcuded: normal EKG;  TSH : 0.008 (01-Nov-2022), 0.006 (07-Nov-2022) and 0.005 (14-Nov-2022); normal T3 & T4; Thyroid Antibody: 32. Treatment included Methimazole. Patient does not have a family history of thyroid dysorder and TSH test was normal prior to vaccination. No further details regarding clinical course, diagnostic tests or treatment performed were disclosed. The benefit-risk relationship of mRNA-1273.222 bivalent vaccine is not affected by this report.