Age: 21.0
Sex: M
Vaccine: MNQ, TDAP
Symptoms: Photophobia, Seizure, Suicidal ideation, Urine output decreased, Visual impairment
Clinical narrative: Clenching of both hands; Suicidal ideation; bladder changes felt urgency to urinate but not much urine would come out; Personality changes; Anemic; Hair falling out; Jaundice; Head banging and pacing; Light sensitivity vision; Weight loss; contraction of mouth/ lips and contraction of both hands; Numbness of both hands; Pacing; vision changes (light sensitivity); Drooling; Spasticity; Seizures; OCD; Stroke like symptoms; Facial drooping; Back pain; Neck pain; trouble breathing; felt bad; This serious case was reported by a consumer via call center representative and described the occurrence of seizure in a 21-year-old male patient who received Men ACWY-CRM NVS (Menveo) for prophylaxis.   Co-suspect products included DTPa (Reduced antigen) (Tdap Vaccine) for prophylaxis and HPV 16-18 (HPV vaccine) for prophylaxis.   Concurrent medical conditions included tic.   On 26-DEC-2016, the patient received Menveo and Tdap Vaccine. In DEC-2016, the patient received the 3rd dose of HPV vaccine. On 26-DEC-2016, less than a day after receiving Menveo and Tdap Vaccine and not applicable after receiving HPV vaccine, the patient experienced feeling bad (Verbatim: felt bad). In DEC-2022, the patient experienced stroke (Verbatim: Stroke like symptoms) (serious criteria GSK medically significant), facial droop (Verbatim: Facial drooping) (serious criteria GSK medically significant), back pain (Verbatim: Back pain), neck pain (Verbatim: Neck pain) and difficulty breathing (Verbatim: trouble breathing). On an unknown date, the patient experienced seizure (Verbatim: Seizures) (serious criteria GSK medically significant), dystonic hand clenching (Verbatim: Clenching of both hands) (serious criteria GSK medically significant), suicidal ideation (Verbatim: Suicidal ideation) (serious criteria GSK medically significant), urinary urgency (Verbatim: bladder changes felt urgency to urinate but not much urine would come out), personality change (Verbatim: Personality changes), anemia (Verbatim: Anemic), hair loss (Verbatim: Hair falling out), jaundice (Verbatim: Jaundice), head banging (Verbatim: Head banging and pacing), photophobia (Verbatim: Light sensitivity vision), weight loss (Verbatim: Weight loss), muscle contractions involuntary (Verbatim: contraction of mouth/ lips and contraction of both hands), numbness in hand (Verbatim: Numbness of both hands), behavior abnormal (Verbatim: Pacing), abnormal vision (Verbatim: vision changes (light sensitivity)), drooling (Verbatim: Drooling), spasticity (Verbatim: Spasticity) and obsessive-compulsive disorder (Verbatim: OCD). the patient experienced . The patient was treated with marijuana. The outcome of the seizure, stroke, facial droop, suicidal ideation, urinary urgency, personality change, anemia, hair loss, jaundice, head banging, photophobia, weight loss, muscle contractions involuntary, feeling bad, abnormal vision, drooling, back pain, neck pain and difficulty breathing were resolved and the outcome of the dystonic hand clenching, numbness in hand, behavior abnormal and spasticity were not resolved and the outcome of the obsessive-compulsive disorder was not reported.   It was unknown if the reporter considered the seizure, stroke, facial droop, dystonic hand clenching, suicidal ideation, urinary urgency, personality change, anemia, hair loss, jaundice, head banging, photophobia, weight loss, muscle contractions involuntary, numbness in hand, behavior abnormal, feeling bad, abnormal vision, drooling, spasticity, back pain, neck pain, difficulty breathing and obsessive-compulsive disorder to be related to Menveo and Tdap Vaccine. It was unknown if the reporter considered the seizure, stroke, facial droop, dystonic hand clenching, suicidal ideation, urinary urgency, personality change, anemia, hair loss, jaundice, head banging, photophobia, weight loss, muscle contractions involuntary, numbness in hand, behavior abnormal, abnormal vision, drooling, spasticity, back pain, neck pain, difficulty breathing and obsessive-compulsive disorder to be related to HPV vaccine.     It was unknown if the company considered the seizure, stroke, facial droop, dystonic hand clenching, suicidal ideation, urinary urgency, personality change, anemia, hair loss, jaundice, head banging, photophobia, weight loss, muscle contractions involuntary, numbness in hand, behavior abnormal, feeling bad, abnormal vision, drooling, spasticity, back pain, neck pain, difficulty breathing and obsessive-compulsive disorder to be related to Menveo and Tdap Vaccine. It was unknown if the company considered the seizure, stroke, facial droop, dystonic hand clenching, suicidal ideation, urinary urgency, personality change, anemia, hair loss, jaundice, head banging, photophobia, weight loss, muscle contractions involuntary, numbness in hand, behavior abnormal, abnormal vision, drooling, spasticity, back pain, neck pain, difficulty breathing and obsessive-compulsive disorder to be related to HPV vaccine.   Additional Information: GSK Receipt Date: 22-Nov-2023 The patient was self-reported this case. The patient received Menveo and Tdap vaccine and on same day felt bad. The patient stated that two days later he received his 3rd HPV shot.  The reporter stated that a few days later he experienced bladder changes where he felt urgency to urinate but not much urine would come out, personality changes as well. The patient stated that weeks later he stated his hair was falling out, anemic, seizures, jaundice, head banging and pacing.  The patient mentioned he experienced contraction of lips with drooling, spasticity and contraction of both hands, light sensitivity, suicidal ideation and weight loss. In December of 2022 patient had stroke like symptoms, facial drooping, neck and back pain and trouble breathing and went to emergency room.  Patient was diagnosed with OCD. The patient stated that they put him on medical marijuana which helps to resolve some of his symptoms. The reporter did consent to follow up.