Age: 80.0
Sex: F
Vaccine: COVID19
Symptoms: Pyrexia, Refusal of treatment by patient, Rhinovirus infection, Septic shock, Vasopressive therapy
Clinical narrative: SEPTIC SHOCK; BLOOD LACTIC ACID INCREASED; DYSPNEA; RHINOVIRUS INFECTION; LUNG INFILTRATION; PYREXIA; GENERAL PHYSICAL HEALTH DETERIORATION; ENDOTRACHEAL INTUBATION; HUMAN RHINOVIRUS TEST POSITIVE; OXYGEN SATURATION DECREASED; PROCALCITONIN INCREASED; BILEVEL POSITIVE AIRWAY PRESSURE; REFUSAL OF TREATMENT BY PATIENT; VASOPRESSIVE THERAPY; This spontaneous report received from a health care professional via a company representative via social media via Regulatory Authority VAERS (Vaccine adverse event reporting system, VAERS ID 1102815) concerned an 87 year old female of an unspecified race and ethnicity. The patient's height, and weight were not reported. The patient's concurrent conditions included: COPD (Chronic obstructive pulmonary disease), diastolic congestive heart failure, pre-diabetic, hypertension, and penicillin allergy, and other pre-existing medical conditions included: The patient had history of chronic oxygen dependency. 2-3 weeks prior to vaccine the patient was croupy and saw a pulmonologist and lungs were clear, on and off antibiotics from 12-FEB-2021 to 05-MAR-2021. Failed stress test (occlusion of left anterior descending artery) and recommended cardiac cath and had a cardiac implant, possibly defibrillator. The patient received covid-19 vaccine ad26.cov2.s (suspension for injection, intramuscular, batch number: 1805018 expiry: UNKNOWN) dose was not reported, 1 total administered to left arm on 05-MAR-2021 for an unspecified indication. Age at time of vaccination 9 decade old. Concomitant medications included acetylsalicylic acid, alprazolam, amlodipine, atorvastatin, atorvastatin calcium, azelastine hydrochloride/fluticasone propionate, azithromycin, biotin, cefuroxime, dexlansoprazole, fenofibrate, fluticasone, fluticasone propionate/salmeterol xinafoate, hydrochlorothiazide, isosorbide mononitrate, levothyroxine, loratadine, magnesium, and umeclidinium bromide for an unspecififed indication.  On 09-MAR-2021, the patient experienced septic shock, bilevel positive airway pressure, blood lactic acid increased, dyspnea, endotracheal intubation, general physical health deterioration, human rhinovirus test positive, lung infiltration, oxygen saturation decreased, procalcitonin increased, pyrexia, refusal of treatment by patient, rhinovirus infection, and vasopressive therapy. On the same, Laboratory data included: Blood lactic acid Increased, Human rhinovirus test Positive, Oxygen saturation Decreased, and Procalcitonin Increased. On 11-MAR-2021, the patient was hospitalized with shortness of breath. The patient had the history of chronic oxygen dependency at night. Became more SOB (shortness of breath) over last several days and was not able to make it to MD appointment. The patient visited to emergency room and the number of days hospitalized was 2. On the same day, Laboratory data included: Human rhinovirus test Positive, Lactic acid 33.5, and Procalcitonin 54.97. On an unspecified date, the patient had a recent abnormal stress test. Family states she was febrile at home. Was low on oxygen level on 2LNC, placed on non-rebreather and then BIPAP. Chest x-ray showed bilateral lower infiltrates. Patient condition was deteriorated through the night and was intubated and placed on vasopressors for septic shock. Patient was made DNR and family refused hemodialysis. Family then made decision to withdraw care. On 12-MAR-2021, the patient died from bilevel positive airway pressure, blood lactic acid increased, dyspnea, endotracheal intubation, general physical health deterioration, human rhinovirus test positive, lung infiltration, oxygen saturation decreased, procalcitonin increased, pyrexia, refusal of treatment by patient, rhinovirus infection, septic shock, and vasopressive therapy. It was unknown whether an autopsy was performed or not. On the same day, Laboratory data included: Lactic acid 72.4, and Procalcitonin 98.61. The action taken with covid-19 vaccine ad26.cov2.s was not applicable. This report was serious (Death, and Hospitalization Caused / Prolonged). This case, from the same reporter is linked to 20230123136, 20230123132, 20230123126 and 20210650125.; Sender's Comments: V0: 20230124166-SEPTIC SHOCK,  BILEVEL POSITIVE AIRWAY PRESSURE, BLOOD LACTIC ACID INCREASED, DYSPNEA, ENDOTRACHEAL INTUBATION, GENERAL PHYSICAL HEALTH DETERIORATION, HUMAN RHINOVIRUS TEST POSITIVE, LUNG INFILTRATION, OXYGEN SATURATION DECREASED, PROCALCITONIN INCREASED, PYREXIA, REFUSAL OF TREATMENT BY PATIENT, RHINOVIRUS INFECTION, VASOPRESSIVE THERAPY  The event has a compatible/suggestive temporal relationship, is unlabeled, and has unknown scientific plausibility. There are other factors more likely to be associated with the event. Specifically: MEDICAL HISTORY. Therefore, this event is considered inconsistent with vaccine administration.; Reported Cause(s) of Death: BILEVEL POSITIVE AIRWAY PRESSURE; BLOOD LACTIC ACID INCREASED; DYSPNEA; ENDOTRACHEAL INTUBATION; GENERAL PHYSICAL HEALTH DETERIORATION; HUMAN RHINOVIRUS TEST POSITIVE; LUNG INFILTRATION; OXYGEN SATURATION DECREASED; PROCALCITONIN INCREASED; PYREXIA;