Age: 57.0
Sex: F
Vaccine: COVID19
Symptoms: Magnetic resonance imaging, Meningitis
Clinical narrative: Meningitis after receiving Moderna COVID vaccine; This spontaneous case was reported by a consumer and describes the occurrence of MENINGITIS (Meningitis after receiving Moderna COVID vaccine) in a 57-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 036A2 or Z1A and 030B21A) for COVID-19 prophylaxis.    Co-suspect product included non-company product METHYLPREDNISOLONE ACETATE (DEPO-MEDROL) for an unknown indication.    No Medical History information was reported.   On 05-Mar-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 02-Apr-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On an unknown date, the patient started METHYLPREDNISOLONE ACETATE (DEPO-MEDROL) (Intrathecal) at an unspecified dose. On an unknown date, the patient experienced MENINGITIS (Meningitis after receiving Moderna COVID vaccine) (seriousness criterion medically significant). The patient was treated with CLARITHROMYCIN (BIAXIN) at an unspecified dose and frequency. At the time of the report, MENINGITIS (Meningitis after receiving Moderna COVID vaccine) outcome was unknown.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On an unknown date, Magnetic resonance imaging: new damage to  disc; degeneration in the thoracic spine, thecal flattening and spinal cord flattening.         No concomitant medications were reported. It was reported that Meningitis after receiving the first and second doses of the Moderna COVID vaccine. Patient was treated with antibiotics with a refill. Reported that patient was not in good shape. Stated prior to getting vaccine patient had feeling bad with pain that has been progressing. By the 3rd day after the vaccine, patient was horrible. Patient's whole spine was burning and had trouble moving her head. She had previously reported was spinal infections. Her arms were weak and painful. Reported that her back was just burning. Patient had suicidal pain. There was nothing wrong with the pain medications. Took the antibiotics orally. Pain to the adhesive arachnoiditis she got after receiving depo-medrol intrathecally. The problems with her spine are a combination between the depo-medrol and the infections in her spine have burned her back up.  This case was identified as part of a retrospective clean-up activity where certain emails received in the Moderna mailbox were missed to be booked-in.   Reporter did not allow further contact; Sender's Comments: This spontaneous case concerns a 57-year-old female patient with concurrent Adhesive arachnoiditis, and use of Methylprednisolone acetate via intrathecal route, who experienced the unexpected, serious  (medically significant) adverse event of special interest Meningitis (Meningitis after receiving Moderna COVID vaccine) on an unknown date in the context of receiving mRNA-1273 vaccine.  Onset latency could not be determined as onset date of the event was not specified. Patient reported that she had Meningitis after receiving the first and second dose of the Moderna vaccine. The event meningitis was reportedly diagnosed clinically as no spinal tap was performed, while the magnetic resonance imaging reported was in relation to Adhesive arachnoiditis.   Unspecified antibiotics were taken on both occasions. Patient received a 2-dose primary series of mRNA-1273 vaccine given 28 days apart. The concurrent Adhesive arachnoiditis and use of Methylprednisolone acetate via intrathecal route could be considered as risk factors. The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report.