Age: 42.0
Sex: F
Vaccine: COVID19
Symptoms: Muscle twitching, Muscular weakness, Musculoskeletal stiffness, Myoclonus, Neuralgia
Clinical narrative: November 2022 - extreme tendonitis in both knees, but the left side was worse, weight 125lbs.  December 2022 - extreme tendonitis in both elbows, but the left side was worse, started PT as recommended by orthopedist.   January 2023 - unintentional weight loss, blood work found iron deficiency anemia, B12 deficiency, D deficiency, continuation of tendon pain in elbows and knees, extreme fatigue, PT was making the pain worse, so discontinued PT.  Weight loss down to 116 lbs.   February 2023 - extreme pain/burning sensation in thighs, nerve pain in both legs, neurological symptoms - twitching muscles, brain fog, more unintentional weight loss, extreme fatigue, extreme tinnitus in both ears, start of unusual menstrual cycles that included very heavy bleeding and cramping.  Legs were stiff, bending them or crossing my legs would make the pain even worse, so I had to keep them straight at all times.  Weight loss down to 112 lbs.  This is when I really started to notice sleep myoclonus hypnic jerking.  It would happen many times throughout the day and not just when I was starting to fall asleep.  I could be standing at the fridge about to get something and my whole arm, shoulder would jerk.  It was very scary.  March 2023 - Continuation of all the symptoms from February, plus gastrointestinal distress (diarrhea, undigested food particles in stool), discovered an intolerance to exercise - exercise produced extreme pain in both thighs that lasted for 2 and a half weeks, including the feeling of pressure, burning, searing pain.  The main nerve up both legs was very painful as well.  My body continued to have myoclonus hypnic jerking when awake and when going to sleep.  April 2023 - Continuation of all the symptoms from March, diagnosed as vaccine injured by Dr. and her nurse based on blood work and extremely high cytokines, (started on a treatment protocol of Maraviroc and Pravastatin through August 2023).  Also started seeing a nutritionist to address gut dysbiosis.  May-July 2023 - Continuation of all the symptoms, plus SIBO, Candida overgrowth, leaky gut, weight loss down to 106 lbs.  When I get my period, my legs flare up really badly.    August 2023 - Thigh pain persists in both thighs, left elbow continued to have tendonitis (same arm all 4 mRNA shots were given), sometimes there is pain in the right elbow.  Neurological symptoms of random muscle twitching and activating happened randomly throughout the day, tinnitus, vitamin deficiencies in iron, D, A, B12 binding capacity, and leaky gut.  September-December 2023 - All the symptoms continued, my gut got worse, my legs got worse.  After dental work was done to put a crown in, my gums would not heal, which lasted from September through November.  We had switched to the Fullscript Post-Viral Recovery Protocol, which included Arterosil, Tollovid, MegaSporeBiotic, MegaPre, and ITIS.  This protocol made my symptoms worse and I stopped at the end of November and switched to a functional integrative doctor.  She did an Endopat test and found significant damage and stiffness in the endothelial lining of my vascular system (that is my layman?s understanding of that test and what it found). I continued taking Low Dose Naltrexone, and started on Ivermectin, B1 supplements, Tudca, and RegeneVasc.  Early December 2023 - Got Covid for the first time with symptoms similar to vaccine effects that lasted for 3 weeks, headache, body aches, fatigue, brain fog, flu-like symptoms.  I continued testing positive for Covid for weeks after initial infection.  Took Paxlovid immediately after a positive covid test.   January 2024 -March 2024 - Leg pain continued in both thighs, but throughout my vaccine injury, my left thigh has been the worst one.  Diagnosed with IBS.  Continued unusual menstrual cycles with periods that were heavy with lots of spotting weeks ahead of time.  March 2024-June 2024 - Leg pain continues, issues with heavy and crampy periods, as well as periods coming every 2 and a half weeks.  Started gaining weight, up to 115 lbs. by the end of June by addressing IBS with Nerva hypnotherapy app, as well as an anti-inflammatory diet (no gluten or sugar), and other digestive supplements as recommended by my nutritionist.  July-Sept 2024 - Leg pain is mostly in the left thigh.  Some days the pain is barely there and I can ignore it, and some days it?s more pronounced.  My periods have been short and painful and bloody.    Oct-Dec. 2024 - My legs were at a 1 on the pain scale if zero is pain-free.  I had 3 weird days where my leg pain increased to a 4-5.  My VEGF was low and my doctor believes that not enough oxygen is getting to my tissues, which might be causing leg pain and weakness.  My period is very short, crampy, and heavy, which are all out of the ordinary.  My DHEA, and Zinc are low.  A spike protein antibody test showed I had greater than 25,000, but I have not been actively infected with Covid nor sick with anything else since December of 2023.  Jan-June 2025 - Leg pain is under control due to supplements and drugs I?m taking. Thigh muscles are still not normal and can have discomfort and mild pain, which increases the more I exert them. They fatigue very easily (just bending over into a small squat to tie my shoes will tire them out).  The left arm and elbow continue to have pain in the tendon area when used.  Some nights I will wake up with internal tremors.  I have gained weight and am back up to a semi-normal range for me around 121 pounds.  My periods continue to be erratic and unusual.  The cramps have been really intense.  My period only lasts for 3-4 days and comes sometimes twice a month.  Here is what I?ve been taking since January 2025 that seems to have helped the most with thigh pain and Post-Acute Covid-19 Vaccination Syndrome (PACVS) symptoms: LDN (Low Dose Naltrexone)  Ivermectin - 26mg daily Augmented NAC Ortho digestzymes with every meal Mitocore TB-4 Peptides - (Started June 1, 2025) BCP-157 peptides Rhodiola Rosea  Zinc with copper Vitamin D DHEA Femmenessence Harmony Pro SPM Active One Daily (Fish oil)  June-July 2025 - I will be starting hypobaric oxygen therapy 6/16/25 at the recommendation of Dr.  We will be running another covid long hauler panel after this therapy, as well as another GI Map.