Age: 68.0
Sex: F
Vaccine: COVID19, COVID19, COVID19
Symptoms: Speech disorder, Swollen tongue
Clinical narrative: patient developed asthma symptoms/ after the 2nd shot all the symptoms got worse immediately; she had a bruise of the size of an orange in the site of injection in her left upper arm; after the 2nd shot all the symptoms got worse immediately; patient developed flu like symptoms; she couldn't breath; swelling in her mouth; swelling in the back of her throat; swelling in her tongue; she had a hard time swallowing; trouble with speech; This spontaneous case was reported by a patient and describes the occurrence of ASTHMA (patient developed asthma symptoms/ after the 2nd shot all the symptoms got worse immediately), INFLUENZA LIKE ILLNESS (patient developed flu like symptoms), DYSPNOEA (she couldn't breath), MOUTH SWELLING (swelling in her mouth) and PHARYNGEAL SWELLING (swelling in the back of her throat) in a 68-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 006B21A and 014M20A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     The patient did not had COVID positive test or diagnosis.  There were no medical history relating to mentioned AE and both Acute and Chronic illnesses at the time of vaccination  It was reported that patient had no history of COVID-19 infection, Myocarditis or pericarditis.  Previously administered products included for Product used for unknown indication: flu vaccine in October 2021 and Pneumonia vaccine in October 2021. Past adverse reactions to the above products included No adverse event with Pneumonia vaccine and flu vaccine. Family history included Cardiac disorder (Atorvastatin used for family history of cardiac disease) since an unknown date. Concurrent medical conditions included Penicillin allergy and Seasonal allergy. Concomitant products included ATORVASTATIN for Cardiac disorder, METOPROLOL and METFORMIN for an unknown indication.   On 27-Feb-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 27-Mar-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 27-Feb-2021, the patient experienced INFLUENZA LIKE ILLNESS (patient developed flu like symptoms), DYSPNOEA (she couldn't breath), MOUTH SWELLING (swelling in her mouth), PHARYNGEAL SWELLING (swelling in the back of her throat), SWOLLEN TONGUE (swelling in her tongue), DYSPHAGIA (she had a hard time swallowing) and SPEECH DISORDER (trouble with speech). On 27-Mar-2021, the patient experienced ASTHMA (patient developed asthma symptoms/ after the 2nd shot all the symptoms got worse immediately), VACCINATION SITE BRUISING (she had a bruise of the size of an orange in the site of injection in her left upper arm) and CONDITION AGGRAVATED (after the 2nd shot all the symptoms got worse immediately). The patient was treated with CHLORTHALIDONE at a dose of 25 milligram; AMLODIPINE BESYLATE at a dose of 5 milligram once a day; MONTELUKAST SODIUM for Asthma prophylaxis, at a dose of 10 milligram once a day; IBUPROFEN at an unspecified dose and frequency and MOMETASONE FUROATE (FLONASE [MOMETASONE FUROATE]) at an unspecified dose and frequency. At the time of the report, ASTHMA (patient developed asthma symptoms/ after the 2nd shot all the symptoms got worse immediately), INFLUENZA LIKE ILLNESS (patient developed flu like symptoms), MOUTH SWELLING (swelling in her mouth), PHARYNGEAL SWELLING (swelling in the back of her throat), SWOLLEN TONGUE (swelling in her tongue), DYSPHAGIA (she had a hard time swallowing), SPEECH DISORDER (trouble with speech) and VACCINATION SITE BRUISING (she had a bruise of the size of an orange in the site of injection in her left upper arm) had not resolved, DYSPNOEA (she couldn't breath) was resolving and CONDITION AGGRAVATED (after the 2nd shot all the symptoms got worse immediately) outcome was unknown.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On an unknown date, Blood pressure measurement: 145/75 due to the medications. On an unknown date, Blood test: Normal. On an unknown date, Magnetic resonance imaging: Normal. On an unknown date, White blood cell count: Low. On an unknown date, X-ray: Normal.         After the 2nd shot all the symptoms got worse immediately, and patient had a bruise of the size of an orange in the site of injection in left upper arm, and even with treatment, did not recovered as well as after the first dose, she recovered only like two thirds of the way. Doctors added Ibuprofen and Flonase but they stopped it because those didn't work.   Doctors made a lot of tests, MRI, chest X-rays, blood tests, but everything seemed to be normal, except for her blood pressure, but it was due to the medications (145/75), and her white blood cells were low, but doctors told her it was normal because of the vaccine.  It was reported that after all this treatment, symptoms still ongoing, breathing was improved, but the other symptoms were same   This case was linked to MOD-2022-637082, MOD-2022-637072 (Patient Link).