Age: 52.0
Sex: F
Vaccine: COVID19, COVID19
Symptoms: Depression suicidal, Feeling abnormal, Hangover, Tearfulness
Clinical narrative: extremely depressed for over a week/depression was very bad/felt like she did not want to live & she spent 4 days in a psyche ward; felt like she had a hangover effect like she had a toxin in her body; felt spacy/wondering where her water bottle was even though it was in her hand; busted out in tears; This spontaneous case was reported by a patient and describes the occurrence of DEPRESSION SUICIDAL (extremely depressed for over a week/depression was very bad/felt like she did not want to live & she spent 4 days in a psyche ward) in a 52-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 051B22A, 051B22A and 031L20A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     The patient's past medical history included Depression. Previously administered products included for Drug use for unknown indication: Pfizer (Booster dose with all the other doses she had got sick for about a day and a half starting about 5 hours after the dose) on 02-Oct-2021. Past adverse reactions to the above products included Sickness with Pfizer. Concomitant products included SERTRALINE HYDROCHLORIDE (ZOLOFT) for Depression.   On 12-Feb-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 26-Jul-2022, received fourth dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On an unknown date, the patient received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 26-Jul-2022, the patient experienced FEELING ABNORMAL (felt spacy/wondering where her water bottle was even though it was in her hand) and TEARFULNESS (busted out in tears). On an unknown date, the patient experienced DEPRESSION SUICIDAL (extremely depressed for over a week/depression was very bad/felt like she did not want to live & she spent 4 days in a psyche ward) (seriousness criteria hospitalization and medically significant) and HANGOVER (felt like she had a hangover effect like she had a toxin in her body). At the time of the report, DEPRESSION SUICIDAL (extremely depressed for over a week/depression was very bad/felt like she did not want to live & she spent 4 days in a psyche ward), HANGOVER (felt like she had a hangover effect like she had a toxin in her body), FEELING ABNORMAL (felt spacy/wondering where her water bottle was even though it was in her hand) and TEARFULNESS (busted out in tears) outcome was unknown.        For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown), the reporter did not provide any causality assessments.   Treatment information was not provided. The 2nd booster dose made her extremely depressed for over a week, the depression was very bad, she felt like she did not want to live, and she spent 4 days in a psyche ward. She felt like she had a hangover effect like she had a toxin in her body. Immediately after getting the 2nd dose she went to the store, felt spacy, and was wondered where her water bottle was even though it was in her hand. After that she went to another destination to drop something off and busted out in tears  Company comment  This is a Spontaneous case reported by a patient, concerning a 52-year-old female patient, with relevant medical history of Depression and on Sertraline, who experienced the unexpected, serious (Hospitalization and medically significant) event of DEPRESSION SUICIDAL (extremely depressed for over a week/depression was very bad/felt like she did not want to live & she spent 4 days in a psyche ward) unknown days after the 4 dose of mRNA-1273 vaccine in the covid 19 vaccination series, along with non serious events of FEELING ABNORMAL, TEARFULNESS and HANGOVER  Patient previously received 2 doses with Moderna and a Booster dose with Pfizer vaccines. Interchange of vaccine products was noted. It was reported that with all the other doses she had got sick starting about 5 hours after the dose. Patient had felt sick with Pfizer vaccine. The 2nd booster dose made her extremely depressed for over a week, the depression was very bad, she felt like she did not want to live, and she spent 4 days in a psyche ward. She had a hangover effect like she had a toxin in her body. Immediately after the dose, she went to the store, felt spacy, and was wondering where her water bottle was, even though it was in her hand. After that she went to another destination to drop something off and busted out in tears. Medical history of depression is a confounder. The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report.; Sender's Comments: This is a Spontaneous case reported by a patient, concerning a 52-year-old female patient, with relevant medical history of Depression and on Sertraline, who experienced the unexpected, serious (Hospitalization and medically significant) event of DEPRESSION SUICIDAL (extremely depressed for over a week/depression was very bad/felt like she did not want to live & she spent 4 days in a psyche ward) unknown days after the 4 dose of mRNA-1273 vaccine in the covid 19 vaccination series, along with non serious events of FEELING ABNORMAL, TEARFULNESS and HANGOVER  Patient previously received 2 doses with Moderna and a Booster dose with Pfizer vaccines. Interchange of vaccine products was noted. It was reported that with all the other doses she had got sick starting about 5 hours after the dose. Patient had felt sick with Pfizer vaccine. The 2nd booster dose made her extremely depressed for over a week, the depression was very bad, she felt like she did not want to live, and she spent 4 days in a psyche ward. She had a hangover effect like she had a toxin in her body. Immediately after the dose, she went to the store, felt spacy, and was wondering where her water bottle was, even though it was in her hand. After that she went to another destination to drop something off and busted out in tears. Medical history of depression is a confounder. The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report.