Age: 37.0
Sex: F
Vaccine: MMR
Symptoms: Neuropathy, Nuclear magnetic resonance imaging normal, Pain in extremity, Paraesthesia, Skin discolouration
Clinical narrative: Within 24 hours of the MMR I had pins & needles, numbness, discoloration and pain in hands; the pain traveled to my neck.  Two days after the immunization I went to the Chiropractor where my neck was x-rayed and I began weekly adjustments for the next year or more.  These symptoms spread to feet, lower legs, arms, top & base of spine, I also developed overwhelming fatigue, vertigo, balance issues, bladder (periodic incontinence) and bowel issues (constipation), muscle constriction, muscle spasms (buzzing and burning as well), electric like sensations in spine down arm and across face.  My eyes now wiggle from side to side as I try to read and especially when I am tired.  My symptoms progressively got worse by December of 2006 where the pain would wake me up at night.  I consulted my Primary Care Doctor in January of 2007 who suggested that be evaluated to rule out Multiple Sclerosis.  I have had approximately 120 medical tests that include, MRIs, Spinal Tap, evoked potentials (ie EMG, EEG, Baer, ANSAR) a skin biopsy and numerous blood and urine analysis. So far there is no radiologic evidence to suggest I have Multiple Sclerosis however I had an abnormal skin biopsy that indicates that I have a small fiber neuropathy.  I have had three major episodes that left me unable to walk, stand, sit or lay down without excrutiating pain, numbness, weakness, buzzing in various places in my body and overwhelming fatigue.  In addition to my primary care provider, Chiropractor and multiple Neurologists, I have been seen by a Rheumatologst, an ophthalmologist, a nutritionist, an acupunturist and massage therapist. The acupuncture worked for 10 sessions to help manage the pain and then the 11th session it created the symptoms.  I was treated with Pamelor for 6 weeks until I lost my vision (for 15 minutes) and my vertigo worsened.  What has helped with the ovewheming fatigue has been the diet and vitamins suggested by the Nutritionist:  this is a very expensive and time consuming treatment, not to mention controversial.  I have been unable to eat eggs since 3/06 and anything that is sweet aggravates the neuropathy.  I was treated with Steroids and Muscle Relaxants for a week after my last significant episode in November of 2007.  I am currently on Gabapentin to manage the Neuropathy symptoms and so far it has just increased my fatigue, dizziness and constipation and I still have all the other symptoms.  I see the massage therapist every other week to deal with the pain.  None of the Neurologists have been able to give me a prognosis since they have never seen a relapsing remitting neuropathy before.  If I have one more episode my Neurologist will send me back for more MS tests.  02/25/2008 MR received for multiple OVs 1/29/07 to 8/21/07 from PCP with DX: Paresthesias (verified by RN). 03/25/2008 MR received for OVs 11/26/07 and 3/4/08 with DX: Neuropathic pain. Pt reports dx: of Raynaud's  of the L hand beginning 3/2006 following MMR. Heaviness in limbs and weakness noted, difficulty standing and ambulating. Electric shocks and buzzing sensations reported. Neuro exam WNL.  Motor exam WNL.  Sensation intact. 02/03/2010 Neuropathic pain, muscles spams, and constriction, overwhelming fatigue and limited physical ability. Occasional bladder and bowel issues as well.