Age: 71.0
Sex: M
Vaccine: COVID19
Symptoms: Insomnia, Joint swelling, Magnetic resonance imaging, Malaise, Pain in extremity
Clinical narrative: Dizzy; I was anemic; malaise; benign paroxysmol positional vertigo bppv; foot pain; I quickly lost weight, from 170-lbs down to 157-lbs.; Low vitamin D; paronchia; ankle problems began/ankle pain continued,Ankle and foot problems into May,ankles pain; low grade fever; not sleeping through the night; couldn't walk/ limited walking,Pain still lingered with walking. Some days, I could walk alittle, but most days off my feet; arthritis,March 26 severe bilateral ankle arthritis begins; deep fatigue; headache he around base of neck and head; On March 26-27 my ankles started to swell (slightly redened) and it was painful to walk.; coughing more than normal; what everybody else is experiencing/experiencing symptoms; feeling off/"a little punk; This spontaneous case was reported by a consumer and describes the occurrence of GAIT DISTURBANCE (couldn't walk/ limited walking,Pain still lingered with walking. Some days, I could walk alittle, but most days off my feet), DIZZINESS (Dizzy), ANAEMIA (I was anemic), PARONYCHIA (paronchia) and MALAISE (malaise) in a 71-year-old male patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 024M20A and 041L20A) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     The patient's past medical history included Pneumonia (pneumonia he had encountered 20 years ago.), Joint inflammation (He has a history of ankle inflammation in one side), Lymphoma (small lymphoma in his lip), Lymphatic disorder (He had a "lymph fluid bag" around his left ankle with that which resolved over time.) and Radiation therapy (small lymphoma in his lip which he received radiation for about 4-5 years ago.). Concurrent medical conditions included Lipids abnormal. Concomitant products included SIMVASTATIN from 03-Jul-2012 to an unknown date for Lipids abnormal.   On 22-Jan-2021 at 4:05 AM, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On 22-Feb-2021 at 7:30 AM, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. On 23-Feb-2021, the patient experienced VACCINATION COMPLICATION (what everybody else is experiencing/experiencing symptoms) and FEELING ABNORMAL (feeling off/"a little punk). On 06-Mar-2021, the patient experienced FATIGUE (deep fatigue) and HEADACHE (headache he around base of neck and head). In March 2021, the patient experienced JOINT SWELLING (On March 26-27 my ankles started to swell (slightly redened) and it was painful to walk.) and COUGH (coughing more than normal). On 26-Mar-2021, the patient experienced GAIT DISTURBANCE (couldn't walk/ limited walking,Pain still lingered with walking. Some days, I could walk alittle, but most days off my feet) and ARTHRITIS (arthritis,March 26 severe bilateral ankle arthritis begins). On 09-Apr-2021, the patient experienced INSOMNIA (not sleeping through the night), ARTHRALGIA (ankle problems began/ankle pain continued,Ankle and foot problems into May,ankles pain) and PYREXIA (low grade fever). On 01-May-2021, the patient experienced PARONYCHIA (paronchia). On an unknown date, the patient experienced DIZZINESS (Dizzy), ANAEMIA (I was anemic), MALAISE (malaise), VERTIGO POSITIONAL (benign paroxysmol positional vertigo bppv), PAIN IN EXTREMITY (foot pain), WEIGHT DECREASED (I quickly lost weight, from 170-lbs down to 157-lbs.) and VITAMIN D DECREASED (Low vitamin D). The patient was treated with PREDNISONE from 02-Apr-2021 to 08-Apr-2021 for Pain, at an unspecified dose and frequency; MONTELUKAST for Cough, at a dose of 10 milligram; CEPHALEXIN [CEFALEXIN] for Paronychia, at a dose of 500 mg twice a day; IBUPROFEN (ADVIL [IBUPROFEN]) for Adverse event, at a dose of 600 mg twice a day; PARACETAMOL (TYLENOL [PARACETAMOL]) for Adverse event, at an unspecified dose and frequency; IRON for Iron deficiency, at an unspecified dose and frequency and VITAMIN D [VITAMIN D NOS] for Vitamin D supplementation, at an unspecified dose and frequency. On 24-Feb-2021, VACCINATION COMPLICATION (what everybody else is experiencing/experiencing symptoms) and FEELING ABNORMAL (feeling off/"a little punk) had resolved. On 30-Apr-2021, ARTHRITIS (arthritis,March 26 severe bilateral ankle arthritis begins), INSOMNIA (not sleeping through the night) and PYREXIA (low grade fever) had resolved. On 01-Jun-2021, COUGH (coughing more than normal) was resolving. On 05-Aug-2021, WEIGHT DECREASED (I quickly lost weight, from 170-lbs down to 157-lbs.) had resolved. On 11-Oct-2021, VITAMIN D DECREASED (Low vitamin D) had resolved. At the time of the report, GAIT DISTURBANCE (couldn't walk/ limited walking,Pain still lingered with walking. Some days, I could walk alittle, but most days off my feet), DIZZINESS (Dizzy), ANAEMIA (I was anemic), MALAISE (malaise), JOINT SWELLING (On March 26-27 my ankles started to swell (slightly redened) and it was painful to walk.), VERTIGO POSITIONAL (benign paroxysmol positional vertigo bppv) and PAIN IN EXTREMITY (foot pain) outcome was unknown, PARONYCHIA (paronchia) had resolved and FATIGUE (deep fatigue), HEADACHE (headache he around base of neck and head) and ARTHRALGIA (ankle problems began/ankle pain continued,Ankle and foot problems into May,ankles pain) had not resolved.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): In March 2021, Blood test: normal (normal) normal. In March 2021, Chest X-ray: negative (Negative) chest x ray was negative. On 02-Jun-2021, C-reactive protein: high (High) High. On 02-Jun-2021, Haematocrit: 36.5 (Low) 36.5 %. On 02-Jun-2021, Red blood cell sedimentation rate: high (High) High. On 02-Jun-2021, Serum ferritin: high (High) High. On 02-Jun-2021, Weight: 159 (abnormal) 159 lbs. On 03-Jun-2021, Haematocrit: low (Low) Low. On 03-Jun-2021, Vitamin D: 39 (abnormal) mg/ml. On 02-Aug-2021, Weight: 157 (abnormal) 157 lbs. On 05-Aug-2021, Magnetic resonance imaging: abnormal (abnormal) cervical narrowing causing neck pain. On 11-Oct-2021, Weight: 165 (normal) normal. On 03-Nov-2021, C-reactive protein: normal (normal) normal. On 03-Nov-2021, Haematocrit: normal (normal) normal. On 03-Nov-2021, Red blood cell sedimentation rate: normal (normal) normal. On 03-Nov-2021, Serum ferritin: normal (normal) normal. On 03-Nov-2021, Vitamin D: normal (normal) normal. On an unknown date, Blood iron: low (Low) Low around March  then normal in late October. On an unknown date, Blood test: abnormal (abnormal) very high inflammatory factors: ESR, ferritin, c-reactive protein.. On an unknown date, Body temperature: high (High) he had some low grade fever 99 deg F. On an unknown date, C-reactive protein: abnormal (abnormal) slowly returned to normal.. On an unknown date, Red blood cell sedimentation rate: abnormal (abnormal) slowly returned to normal..     For mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular), the reporter did not provide any causality assessments.   The patient experienced symptoms he would put in the category of normal. The patient also took antibiotics as treatment.   This case concerns a 71-year-old male/female patient with a relevant medical history of Ankle Arthritis, who experienced the unexpected non serious event/AESI of Arthritis (ankle arthritis) after mRNA- 1273 Moderna vaccine (Moderna COVID-19 Vaccine / Spikevax). The event occurred approximately 2 month and 5 days after the second dose of mRNA- 1273 vaccine. Treatment with prednisone was prescribed. The rechallenge is not applicable, since the event was reported exclusively after the second dose. Previous history of ankle arthritis remains a confounder. The benefit-risk relationship of mRNA- 1273 vaccine / Moderna COVID-19 Vaccine is not affected by this report   Most recent FOLLOW-UP information incorporated above includes: On 10-Nov-2021: Follow-up received on 10-NOV-2021 included, lab investigation data, vaccination anatomical location, concomitant medications, treatment medications, new events and event outcomes.; Sender's Comments: This spontaneous case concerns a 71-year-old male patient with a relevant medical history of Ankle Arthritis, lymphoma and rasioteraphy, who experienced the unexpected non serious event (AESI) of Arthritis (ankle arthritis) after mRNA- 1273 Moderna vaccine (Moderna COVID-19 Vaccine). The event occurred approximately 1 month and 4 days after the second dose of mRNA- 1273 vaccine. He was also discovered to be anemic but despict that all other lab workup were normal. Treatment with prednisone was prescribed. The rechallenge is not applicable, since the event was reported exclusively after the second dose. Previous history of ankle arthritis remains a confounder. The benefit-risk relationship of mRNA- 1273 vaccine / Moderna COVID-19 Vaccine is not affected by this report.