chrisvoncsefalvay/vaers-narrative-generation huggingface dataset:
Age: 81.0
Sex: F
Vaccine: COVID19
Symptoms: Cyst, Cytomegalovirus test negative, Cytomegalovirus test positive, Decreased appetite, Deep vein thrombosis
Clinical narrative: On 4/7/21, she received the second dose of the Moderna COVID-19 vaccine. Then, around 5/1/21, she developed fevers to 102 with associated fatigue and poor appetite, but no other clear localizing symptoms, including no sore throat, cough, chest pain, SOB, abdominal pain, N/V/D, joint swelling/pain, rashes, or dysuria. She presented to an outside hospital ED where she had an infectious workup that included a CXR concerning for LLL pneumonia. She was prescribed doxycycline for 7 days with resolution of her fevers and subjective improvement.    In early June 2021,  the patient redeveloped fevers and chills, worst at nighttime, without localizing symptoms. Her appetite and energy level remained very poor despite several changes to antidepressants as an outpatient. She was treated with nitrofurantoin x 5 days for presumed UTI, but fevers persisted, still without associated cough, CP, or SOB. With going fevers, fatigue, and poor appetite resulting in ~18lb unintentional weight loss, she was admitted to Hospital on 6/22/21 for further evaluation.  While at Hospital, she continued to have fevers to 102+ without localizing symptoms despite empiric doxycycline. A broad infectious workup returned negative. CT chest and CTAP were also unrevealing for a cause of fevers. She was found to have an elevated ferritin, LDH, and triglycerides, as well as a low fibrinogen, concerning for HLH (high H-score). She received high-dose dexamethasone. Bone marrow biopsy was performed that was negative for malignancy. However, peripheral flow cytometry returned with a clonal B-cell population, her soluble IL-2 was elevated, and she was found to have splenic enhancement on PET-CT, all concerning for occult lymphoma as the potential driver of her HLH. She remains admitted and is critically ill with complications of DIC and bleeding that preclude a splenic biopsy to confirm the suspected diagnosis of lymphoma. Since her fevers, malaise, and fatigue started less than 1 month after her second dose of the Moderna vaccine, and the patient was insistent that she "hadn't felt right" since she received that second dose of the vaccine, we decided to report this event in the VAERS system.
Age: 81.0
Sex: F
Vaccine: COVID19
Symptoms: Disseminated intravascular coagulation, Echocardiogram, Ehrlichia test, Eosinophil count decreased, Eosinophil percentage decreased
Clinical narrative: On 4/7/21, she received the second dose of the Moderna COVID-19 vaccine. Then, around 5/1/21, she developed fevers to 102 with associated fatigue and poor appetite, but no other clear localizing symptoms, including no sore throat, cough, chest pain, SOB, abdominal pain, N/V/D, joint swelling/pain, rashes, or dysuria. She presented to an outside hospital ED where she had an infectious workup that included a CXR concerning for LLL pneumonia. She was prescribed doxycycline for 7 days with resolution of her fevers and subjective improvement.    In early June 2021,  the patient redeveloped fevers and chills, worst at nighttime, without localizing symptoms. Her appetite and energy level remained very poor despite several changes to antidepressants as an outpatient. She was treated with nitrofurantoin x 5 days for presumed UTI, but fevers persisted, still without associated cough, CP, or SOB. With going fevers, fatigue, and poor appetite resulting in ~18lb unintentional weight loss, she was admitted to Hospital on 6/22/21 for further evaluation.  While at Hospital, she continued to have fevers to 102+ without localizing symptoms despite empiric doxycycline. A broad infectious workup returned negative. CT chest and CTAP were also unrevealing for a cause of fevers. She was found to have an elevated ferritin, LDH, and triglycerides, as well as a low fibrinogen, concerning for HLH (high H-score). She received high-dose dexamethasone. Bone marrow biopsy was performed that was negative for malignancy. However, peripheral flow cytometry returned with a clonal B-cell population, her soluble IL-2 was elevated, and she was found to have splenic enhancement on PET-CT, all concerning for occult lymphoma as the potential driver of her HLH. She remains admitted and is critically ill with complications of DIC and bleeding that preclude a splenic biopsy to confirm the suspected diagnosis of lymphoma. Since her fevers, malaise, and fatigue started less than 1 month after her second dose of the Moderna vaccine, and the patient was insistent that she "hadn't felt right" since she received that second dose of the vaccine, we decided to report this event in the VAERS system.
Age: 81.0
Sex: F
Vaccine: COVID19
Symptoms: Epstein-Barr virus antibody negative, Fatigue, Feeling abnormal, Flow cytometry, Gastrooesophageal reflux disease
Clinical narrative: On 4/7/21, she received the second dose of the Moderna COVID-19 vaccine. Then, around 5/1/21, she developed fevers to 102 with associated fatigue and poor appetite, but no other clear localizing symptoms, including no sore throat, cough, chest pain, SOB, abdominal pain, N/V/D, joint swelling/pain, rashes, or dysuria. She presented to an outside hospital ED where she had an infectious workup that included a CXR concerning for LLL pneumonia. She was prescribed doxycycline for 7 days with resolution of her fevers and subjective improvement.    In early June 2021,  the patient redeveloped fevers and chills, worst at nighttime, without localizing symptoms. Her appetite and energy level remained very poor despite several changes to antidepressants as an outpatient. She was treated with nitrofurantoin x 5 days for presumed UTI, but fevers persisted, still without associated cough, CP, or SOB. With going fevers, fatigue, and poor appetite resulting in ~18lb unintentional weight loss, she was admitted to Hospital on 6/22/21 for further evaluation.  While at Hospital, she continued to have fevers to 102+ without localizing symptoms despite empiric doxycycline. A broad infectious workup returned negative. CT chest and CTAP were also unrevealing for a cause of fevers. She was found to have an elevated ferritin, LDH, and triglycerides, as well as a low fibrinogen, concerning for HLH (high H-score). She received high-dose dexamethasone. Bone marrow biopsy was performed that was negative for malignancy. However, peripheral flow cytometry returned with a clonal B-cell population, her soluble IL-2 was elevated, and she was found to have splenic enhancement on PET-CT, all concerning for occult lymphoma as the potential driver of her HLH. She remains admitted and is critically ill with complications of DIC and bleeding that preclude a splenic biopsy to confirm the suspected diagnosis of lymphoma. Since her fevers, malaise, and fatigue started less than 1 month after her second dose of the Moderna vaccine, and the patient was insistent that she "hadn't felt right" since she received that second dose of the vaccine, we decided to report this event in the VAERS system.
Age: 81.0
Sex: F
Vaccine: COVID19
Symptoms: HIV test, Haematocrit decreased, Haematoma, Haemoglobin decreased, Haemolysis
Clinical narrative: On 4/7/21, she received the second dose of the Moderna COVID-19 vaccine. Then, around 5/1/21, she developed fevers to 102 with associated fatigue and poor appetite, but no other clear localizing symptoms, including no sore throat, cough, chest pain, SOB, abdominal pain, N/V/D, joint swelling/pain, rashes, or dysuria. She presented to an outside hospital ED where she had an infectious workup that included a CXR concerning for LLL pneumonia. She was prescribed doxycycline for 7 days with resolution of her fevers and subjective improvement.    In early June 2021,  the patient redeveloped fevers and chills, worst at nighttime, without localizing symptoms. Her appetite and energy level remained very poor despite several changes to antidepressants as an outpatient. She was treated with nitrofurantoin x 5 days for presumed UTI, but fevers persisted, still without associated cough, CP, or SOB. With going fevers, fatigue, and poor appetite resulting in ~18lb unintentional weight loss, she was admitted to Hospital on 6/22/21 for further evaluation.  While at Hospital, she continued to have fevers to 102+ without localizing symptoms despite empiric doxycycline. A broad infectious workup returned negative. CT chest and CTAP were also unrevealing for a cause of fevers. She was found to have an elevated ferritin, LDH, and triglycerides, as well as a low fibrinogen, concerning for HLH (high H-score). She received high-dose dexamethasone. Bone marrow biopsy was performed that was negative for malignancy. However, peripheral flow cytometry returned with a clonal B-cell population, her soluble IL-2 was elevated, and she was found to have splenic enhancement on PET-CT, all concerning for occult lymphoma as the potential driver of her HLH. She remains admitted and is critically ill with complications of DIC and bleeding that preclude a splenic biopsy to confirm the suspected diagnosis of lymphoma. Since her fevers, malaise, and fatigue started less than 1 month after her second dose of the Moderna vaccine, and the patient was insistent that she "hadn't felt right" since she received that second dose of the vaccine, we decided to report this event in the VAERS system.
Age: 81.0
Sex: F
Vaccine: COVID19
Symptoms: Haemorrhage, Haptoglobin normal, Hepatitis A antibody positive, Hepatitis B antibody negative, Hepatitis B surface antigen negative
Clinical narrative: On 4/7/21, she received the second dose of the Moderna COVID-19 vaccine. Then, around 5/1/21, she developed fevers to 102 with associated fatigue and poor appetite, but no other clear localizing symptoms, including no sore throat, cough, chest pain, SOB, abdominal pain, N/V/D, joint swelling/pain, rashes, or dysuria. She presented to an outside hospital ED where she had an infectious workup that included a CXR concerning for LLL pneumonia. She was prescribed doxycycline for 7 days with resolution of her fevers and subjective improvement.    In early June 2021,  the patient redeveloped fevers and chills, worst at nighttime, without localizing symptoms. Her appetite and energy level remained very poor despite several changes to antidepressants as an outpatient. She was treated with nitrofurantoin x 5 days for presumed UTI, but fevers persisted, still without associated cough, CP, or SOB. With going fevers, fatigue, and poor appetite resulting in ~18lb unintentional weight loss, she was admitted to Hospital on 6/22/21 for further evaluation.  While at Hospital, she continued to have fevers to 102+ without localizing symptoms despite empiric doxycycline. A broad infectious workup returned negative. CT chest and CTAP were also unrevealing for a cause of fevers. She was found to have an elevated ferritin, LDH, and triglycerides, as well as a low fibrinogen, concerning for HLH (high H-score). She received high-dose dexamethasone. Bone marrow biopsy was performed that was negative for malignancy. However, peripheral flow cytometry returned with a clonal B-cell population, her soluble IL-2 was elevated, and she was found to have splenic enhancement on PET-CT, all concerning for occult lymphoma as the potential driver of her HLH. She remains admitted and is critically ill with complications of DIC and bleeding that preclude a splenic biopsy to confirm the suspected diagnosis of lymphoma. Since her fevers, malaise, and fatigue started less than 1 month after her second dose of the Moderna vaccine, and the patient was insistent that she "hadn't felt right" since she received that second dose of the vaccine, we decided to report this event in the VAERS system.
Age: 81.0
Sex: F
Vaccine: COVID19
Symptoms: Hepatitis C core antibody negative, Herpes simplex test negative, Leptospira test, Lung opacity, Lymphocyte count decreased
Clinical narrative: On 4/7/21, she received the second dose of the Moderna COVID-19 vaccine. Then, around 5/1/21, she developed fevers to 102 with associated fatigue and poor appetite, but no other clear localizing symptoms, including no sore throat, cough, chest pain, SOB, abdominal pain, N/V/D, joint swelling/pain, rashes, or dysuria. She presented to an outside hospital ED where she had an infectious workup that included a CXR concerning for LLL pneumonia. She was prescribed doxycycline for 7 days with resolution of her fevers and subjective improvement.    In early June 2021,  the patient redeveloped fevers and chills, worst at nighttime, without localizing symptoms. Her appetite and energy level remained very poor despite several changes to antidepressants as an outpatient. She was treated with nitrofurantoin x 5 days for presumed UTI, but fevers persisted, still without associated cough, CP, or SOB. With going fevers, fatigue, and poor appetite resulting in ~18lb unintentional weight loss, she was admitted to Hospital on 6/22/21 for further evaluation.  While at Hospital, she continued to have fevers to 102+ without localizing symptoms despite empiric doxycycline. A broad infectious workup returned negative. CT chest and CTAP were also unrevealing for a cause of fevers. She was found to have an elevated ferritin, LDH, and triglycerides, as well as a low fibrinogen, concerning for HLH (high H-score). She received high-dose dexamethasone. Bone marrow biopsy was performed that was negative for malignancy. However, peripheral flow cytometry returned with a clonal B-cell population, her soluble IL-2 was elevated, and she was found to have splenic enhancement on PET-CT, all concerning for occult lymphoma as the potential driver of her HLH. She remains admitted and is critically ill with complications of DIC and bleeding that preclude a splenic biopsy to confirm the suspected diagnosis of lymphoma. Since her fevers, malaise, and fatigue started less than 1 month after her second dose of the Moderna vaccine, and the patient was insistent that she "hadn't felt right" since she received that second dose of the vaccine, we decided to report this event in the VAERS system.
Age: 81.0
Sex: F
Vaccine: COVID19
Symptoms: Lymphocyte percentage decreased, Lymphoma, Magnetic resonance imaging abdominal abnormal, Malaise, Mitral valve calcification
Clinical narrative: On 4/7/21, she received the second dose of the Moderna COVID-19 vaccine. Then, around 5/1/21, she developed fevers to 102 with associated fatigue and poor appetite, but no other clear localizing symptoms, including no sore throat, cough, chest pain, SOB, abdominal pain, N/V/D, joint swelling/pain, rashes, or dysuria. She presented to an outside hospital ED where she had an infectious workup that included a CXR concerning for LLL pneumonia. She was prescribed doxycycline for 7 days with resolution of her fevers and subjective improvement.    In early June 2021,  the patient redeveloped fevers and chills, worst at nighttime, without localizing symptoms. Her appetite and energy level remained very poor despite several changes to antidepressants as an outpatient. She was treated with nitrofurantoin x 5 days for presumed UTI, but fevers persisted, still without associated cough, CP, or SOB. With going fevers, fatigue, and poor appetite resulting in ~18lb unintentional weight loss, she was admitted to Hospital on 6/22/21 for further evaluation.  While at Hospital, she continued to have fevers to 102+ without localizing symptoms despite empiric doxycycline. A broad infectious workup returned negative. CT chest and CTAP were also unrevealing for a cause of fevers. She was found to have an elevated ferritin, LDH, and triglycerides, as well as a low fibrinogen, concerning for HLH (high H-score). She received high-dose dexamethasone. Bone marrow biopsy was performed that was negative for malignancy. However, peripheral flow cytometry returned with a clonal B-cell population, her soluble IL-2 was elevated, and she was found to have splenic enhancement on PET-CT, all concerning for occult lymphoma as the potential driver of her HLH. She remains admitted and is critically ill with complications of DIC and bleeding that preclude a splenic biopsy to confirm the suspected diagnosis of lymphoma. Since her fevers, malaise, and fatigue started less than 1 month after her second dose of the Moderna vaccine, and the patient was insistent that she "hadn't felt right" since she received that second dose of the vaccine, we decided to report this event in the VAERS system.
Age: 81.0
Sex: F
Vaccine: COVID19
Symptoms: Monocyte count decreased, Monocyte percentage abnormal, Mycobacterium tuberculosis complex test negative, Mycoplasma test, Neutrophil count decreased
Clinical narrative: On 4/7/21, she received the second dose of the Moderna COVID-19 vaccine. Then, around 5/1/21, she developed fevers to 102 with associated fatigue and poor appetite, but no other clear localizing symptoms, including no sore throat, cough, chest pain, SOB, abdominal pain, N/V/D, joint swelling/pain, rashes, or dysuria. She presented to an outside hospital ED where she had an infectious workup that included a CXR concerning for LLL pneumonia. She was prescribed doxycycline for 7 days with resolution of her fevers and subjective improvement.    In early June 2021,  the patient redeveloped fevers and chills, worst at nighttime, without localizing symptoms. Her appetite and energy level remained very poor despite several changes to antidepressants as an outpatient. She was treated with nitrofurantoin x 5 days for presumed UTI, but fevers persisted, still without associated cough, CP, or SOB. With going fevers, fatigue, and poor appetite resulting in ~18lb unintentional weight loss, she was admitted to Hospital on 6/22/21 for further evaluation.  While at Hospital, she continued to have fevers to 102+ without localizing symptoms despite empiric doxycycline. A broad infectious workup returned negative. CT chest and CTAP were also unrevealing for a cause of fevers. She was found to have an elevated ferritin, LDH, and triglycerides, as well as a low fibrinogen, concerning for HLH (high H-score). She received high-dose dexamethasone. Bone marrow biopsy was performed that was negative for malignancy. However, peripheral flow cytometry returned with a clonal B-cell population, her soluble IL-2 was elevated, and she was found to have splenic enhancement on PET-CT, all concerning for occult lymphoma as the potential driver of her HLH. She remains admitted and is critically ill with complications of DIC and bleeding that preclude a splenic biopsy to confirm the suspected diagnosis of lymphoma. Since her fevers, malaise, and fatigue started less than 1 month after her second dose of the Moderna vaccine, and the patient was insistent that she "hadn't felt right" since she received that second dose of the vaccine, we decided to report this event in the VAERS system.
Age: 81.0
Sex: F
Vaccine: COVID19
Symptoms: Neutrophil percentage increased, Parvovirus B19 test negative, Platelet count decreased, Pleural effusion, Polymerase chain reaction
Clinical narrative: On 4/7/21, she received the second dose of the Moderna COVID-19 vaccine. Then, around 5/1/21, she developed fevers to 102 with associated fatigue and poor appetite, but no other clear localizing symptoms, including no sore throat, cough, chest pain, SOB, abdominal pain, N/V/D, joint swelling/pain, rashes, or dysuria. She presented to an outside hospital ED where she had an infectious workup that included a CXR concerning for LLL pneumonia. She was prescribed doxycycline for 7 days with resolution of her fevers and subjective improvement.    In early June 2021,  the patient redeveloped fevers and chills, worst at nighttime, without localizing symptoms. Her appetite and energy level remained very poor despite several changes to antidepressants as an outpatient. She was treated with nitrofurantoin x 5 days for presumed UTI, but fevers persisted, still without associated cough, CP, or SOB. With going fevers, fatigue, and poor appetite resulting in ~18lb unintentional weight loss, she was admitted to Hospital on 6/22/21 for further evaluation.  While at Hospital, she continued to have fevers to 102+ without localizing symptoms despite empiric doxycycline. A broad infectious workup returned negative. CT chest and CTAP were also unrevealing for a cause of fevers. She was found to have an elevated ferritin, LDH, and triglycerides, as well as a low fibrinogen, concerning for HLH (high H-score). She received high-dose dexamethasone. Bone marrow biopsy was performed that was negative for malignancy. However, peripheral flow cytometry returned with a clonal B-cell population, her soluble IL-2 was elevated, and she was found to have splenic enhancement on PET-CT, all concerning for occult lymphoma as the potential driver of her HLH. She remains admitted and is critically ill with complications of DIC and bleeding that preclude a splenic biopsy to confirm the suspected diagnosis of lymphoma. Since her fevers, malaise, and fatigue started less than 1 month after her second dose of the Moderna vaccine, and the patient was insistent that she "hadn't felt right" since she received that second dose of the vaccine, we decided to report this event in the VAERS system.
Age: 81.0
Sex: F
Vaccine: COVID19
Symptoms: Positron emission tomogram abnormal, Protein total abnormal, Pulmonary embolism, Pulmonary mass, Pyrexia
Clinical narrative: On 4/7/21, she received the second dose of the Moderna COVID-19 vaccine. Then, around 5/1/21, she developed fevers to 102 with associated fatigue and poor appetite, but no other clear localizing symptoms, including no sore throat, cough, chest pain, SOB, abdominal pain, N/V/D, joint swelling/pain, rashes, or dysuria. She presented to an outside hospital ED where she had an infectious workup that included a CXR concerning for LLL pneumonia. She was prescribed doxycycline for 7 days with resolution of her fevers and subjective improvement.    In early June 2021,  the patient redeveloped fevers and chills, worst at nighttime, without localizing symptoms. Her appetite and energy level remained very poor despite several changes to antidepressants as an outpatient. She was treated with nitrofurantoin x 5 days for presumed UTI, but fevers persisted, still without associated cough, CP, or SOB. With going fevers, fatigue, and poor appetite resulting in ~18lb unintentional weight loss, she was admitted to Hospital on 6/22/21 for further evaluation.  While at Hospital, she continued to have fevers to 102+ without localizing symptoms despite empiric doxycycline. A broad infectious workup returned negative. CT chest and CTAP were also unrevealing for a cause of fevers. She was found to have an elevated ferritin, LDH, and triglycerides, as well as a low fibrinogen, concerning for HLH (high H-score). She received high-dose dexamethasone. Bone marrow biopsy was performed that was negative for malignancy. However, peripheral flow cytometry returned with a clonal B-cell population, her soluble IL-2 was elevated, and she was found to have splenic enhancement on PET-CT, all concerning for occult lymphoma as the potential driver of her HLH. She remains admitted and is critically ill with complications of DIC and bleeding that preclude a splenic biopsy to confirm the suspected diagnosis of lymphoma. Since her fevers, malaise, and fatigue started less than 1 month after her second dose of the Moderna vaccine, and the patient was insistent that she "hadn't felt right" since she received that second dose of the vaccine, we decided to report this event in the VAERS system.
Age: 81.0
Sex: F
Vaccine: COVID19
Symptoms: Renal cyst, SARS-CoV-2 test negative, Scan with contrast abnormal, Scoliosis, Serum ferritin increased
Clinical narrative: On 4/7/21, she received the second dose of the Moderna COVID-19 vaccine. Then, around 5/1/21, she developed fevers to 102 with associated fatigue and poor appetite, but no other clear localizing symptoms, including no sore throat, cough, chest pain, SOB, abdominal pain, N/V/D, joint swelling/pain, rashes, or dysuria. She presented to an outside hospital ED where she had an infectious workup that included a CXR concerning for LLL pneumonia. She was prescribed doxycycline for 7 days with resolution of her fevers and subjective improvement.    In early June 2021,  the patient redeveloped fevers and chills, worst at nighttime, without localizing symptoms. Her appetite and energy level remained very poor despite several changes to antidepressants as an outpatient. She was treated with nitrofurantoin x 5 days for presumed UTI, but fevers persisted, still without associated cough, CP, or SOB. With going fevers, fatigue, and poor appetite resulting in ~18lb unintentional weight loss, she was admitted to Hospital on 6/22/21 for further evaluation.  While at Hospital, she continued to have fevers to 102+ without localizing symptoms despite empiric doxycycline. A broad infectious workup returned negative. CT chest and CTAP were also unrevealing for a cause of fevers. She was found to have an elevated ferritin, LDH, and triglycerides, as well as a low fibrinogen, concerning for HLH (high H-score). She received high-dose dexamethasone. Bone marrow biopsy was performed that was negative for malignancy. However, peripheral flow cytometry returned with a clonal B-cell population, her soluble IL-2 was elevated, and she was found to have splenic enhancement on PET-CT, all concerning for occult lymphoma as the potential driver of her HLH. She remains admitted and is critically ill with complications of DIC and bleeding that preclude a splenic biopsy to confirm the suspected diagnosis of lymphoma. Since her fevers, malaise, and fatigue started less than 1 month after her second dose of the Moderna vaccine, and the patient was insistent that she "hadn't felt right" since she received that second dose of the vaccine, we decided to report this event in the VAERS system.
Age: 81.0
Sex: F
Vaccine: COVID19
Symptoms: Splenomegaly, Thyroxine, Treponema test negative, Ultrasound Doppler, Ultrasound pelvis abnormal
Clinical narrative: On 4/7/21, she received the second dose of the Moderna COVID-19 vaccine. Then, around 5/1/21, she developed fevers to 102 with associated fatigue and poor appetite, but no other clear localizing symptoms, including no sore throat, cough, chest pain, SOB, abdominal pain, N/V/D, joint swelling/pain, rashes, or dysuria. She presented to an outside hospital ED where she had an infectious workup that included a CXR concerning for LLL pneumonia. She was prescribed doxycycline for 7 days with resolution of her fevers and subjective improvement.    In early June 2021,  the patient redeveloped fevers and chills, worst at nighttime, without localizing symptoms. Her appetite and energy level remained very poor despite several changes to antidepressants as an outpatient. She was treated with nitrofurantoin x 5 days for presumed UTI, but fevers persisted, still without associated cough, CP, or SOB. With going fevers, fatigue, and poor appetite resulting in ~18lb unintentional weight loss, she was admitted to Hospital on 6/22/21 for further evaluation.  While at Hospital, she continued to have fevers to 102+ without localizing symptoms despite empiric doxycycline. A broad infectious workup returned negative. CT chest and CTAP were also unrevealing for a cause of fevers. She was found to have an elevated ferritin, LDH, and triglycerides, as well as a low fibrinogen, concerning for HLH (high H-score). She received high-dose dexamethasone. Bone marrow biopsy was performed that was negative for malignancy. However, peripheral flow cytometry returned with a clonal B-cell population, her soluble IL-2 was elevated, and she was found to have splenic enhancement on PET-CT, all concerning for occult lymphoma as the potential driver of her HLH. She remains admitted and is critically ill with complications of DIC and bleeding that preclude a splenic biopsy to confirm the suspected diagnosis of lymphoma. Since her fevers, malaise, and fatigue started less than 1 month after her second dose of the Moderna vaccine, and the patient was insistent that she "hadn't felt right" since she received that second dose of the vaccine, we decided to report this event in the VAERS system.
Age: 81.0
Sex: F
Vaccine: COVID19
Symptoms: Urinary tract infection, Urine analysis abnormal, Weight decreased, White blood cell count decreased
Clinical narrative: On 4/7/21, she received the second dose of the Moderna COVID-19 vaccine. Then, around 5/1/21, she developed fevers to 102 with associated fatigue and poor appetite, but no other clear localizing symptoms, including no sore throat, cough, chest pain, SOB, abdominal pain, N/V/D, joint swelling/pain, rashes, or dysuria. She presented to an outside hospital ED where she had an infectious workup that included a CXR concerning for LLL pneumonia. She was prescribed doxycycline for 7 days with resolution of her fevers and subjective improvement.    In early June 2021,  the patient redeveloped fevers and chills, worst at nighttime, without localizing symptoms. Her appetite and energy level remained very poor despite several changes to antidepressants as an outpatient. She was treated with nitrofurantoin x 5 days for presumed UTI, but fevers persisted, still without associated cough, CP, or SOB. With going fevers, fatigue, and poor appetite resulting in ~18lb unintentional weight loss, she was admitted to Hospital on 6/22/21 for further evaluation.  While at Hospital, she continued to have fevers to 102+ without localizing symptoms despite empiric doxycycline. A broad infectious workup returned negative. CT chest and CTAP were also unrevealing for a cause of fevers. She was found to have an elevated ferritin, LDH, and triglycerides, as well as a low fibrinogen, concerning for HLH (high H-score). She received high-dose dexamethasone. Bone marrow biopsy was performed that was negative for malignancy. However, peripheral flow cytometry returned with a clonal B-cell population, her soluble IL-2 was elevated, and she was found to have splenic enhancement on PET-CT, all concerning for occult lymphoma as the potential driver of her HLH. She remains admitted and is critically ill with complications of DIC and bleeding that preclude a splenic biopsy to confirm the suspected diagnosis of lymphoma. Since her fevers, malaise, and fatigue started less than 1 month after her second dose of the Moderna vaccine, and the patient was insistent that she "hadn't felt right" since she received that second dose of the vaccine, we decided to report this event in the VAERS system.
Age: 30.0
Sex: F
Vaccine: COVID19, COVID19
Symptoms: Blood creatine, Blood magnesium normal, Blood potassium normal, Blood test normal, Blood thyroid stimulating hormone normal
Clinical narrative: I had a fever the day after having the vaccine, after the fever on 05/18/21 I started experiencing heart palpitations and what felt like an elevated heart rate. I felt heart palpitations (a heavy heartbeat sometimes followed by a racing heart) every 1-5 minutes for the first week. My heart rate was in the normal range, but it still felt fast. I was not able to sleep well the week after getting the vaccine.  The heart palpitations decreased over the next weeks, and appeared to go away completely at approximately 1 month (06/18/21).
Age: 30.0
Sex: F
Vaccine: COVID19, COVID19
Symptoms: Full blood count normal, Heart rate increased, Palpitations, Pyrexia, Sleep disorder
Clinical narrative: I had a fever the day after having the vaccine, after the fever on 05/18/21 I started experiencing heart palpitations and what felt like an elevated heart rate. I felt heart palpitations (a heavy heartbeat sometimes followed by a racing heart) every 1-5 minutes for the first week. My heart rate was in the normal range, but it still felt fast. I was not able to sleep well the week after getting the vaccine.  The heart palpitations decreased over the next weeks, and appeared to go away completely at approximately 1 month (06/18/21).
Age: 27.0
Sex: F
Vaccine: COVID19
Symptoms: Contusion, Musculoskeletal discomfort
Clinical narrative: Two days after patient's second dose, she discovered large areas of bruising on left leg (from groin to knee) and on left hip.
Age: 16.0
Sex: M
Vaccine: COVID19
Symptoms: Drug screen, Full blood count, Magnetic resonance imaging head, Metabolic function test, New daily persistent headache
Clinical narrative: New Daily Persistent Headache (G44.52)
Age: 16.0
Sex: M
Vaccine: COVID19
Symptoms: Venogram
Clinical narrative: New Daily Persistent Headache (G44.52)
Age: 18.0
Sex: M
Vaccine: COVID19
Symptoms: Pruritus, Urticaria
Clinical narrative: MOTHER CALLED IN STATING SON HAD HIVES AND WAS VERY ITCHY. HIVES WERE NOT LOCALIZED TO SITE OF ADMINISTRATION AND SPREAD ONTO TORSO. RECOMMENDED BENADRYL, MONITORING AND IF IT PROGRESSED OR NOTICED TROUBLE BREATHING TO PROCEED TO THE EMERGENCY DEPARTMENT.
Age: 14.0
Sex: F
Vaccine: COVID19
Symptoms: Asthenia, Full blood count, Lethargy, Metabolic function test, Respiratory viral panel
Clinical narrative: Fainting, weakness, lethargy
Age: 14.0
Sex: F
Vaccine: COVID19
Symptoms: Syncope, Urine analysis
Clinical narrative: Fainting, weakness, lethargy
Age: 53.0
Sex: F
Vaccine: COVID19
Symptoms: Injection site induration, Injection site nodule, Pyrexia, Rash erythematous, Rash pruritic
Clinical narrative: Fever around 101  for 3 days, hard/swollen knot at injection site, rash that broke out on right side of neck going down straight line to into my breast that was red/ itchy and eventually scabbed over and still have scars in placed
Age: 53.0
Sex: F
Vaccine: COVID19
Symptoms: Scab
Clinical narrative: Fever around 101  for 3 days, hard/swollen knot at injection site, rash that broke out on right side of neck going down straight line to into my breast that was red/ itchy and eventually scabbed over and still have scars in placed
Age: 20.0
Sex: M
Vaccine: COVID19
Symptoms: Fall, Syncope
Clinical narrative: Approximately 5 minutes after vaccination, patient fainted and fell out of chair she was waiting in for post-vaccine observation. She fell on her right said on to the floor. I conducted a physical assessment for bruises, bleeding, broken bones, etc. as well as assessment for breathing and pulse. She was responsive to commands. We followed our emergency protocol and called EMS, who arrived within 5 minutes to further assess the patient. They obtained BP, pulse, and blood sugar readings (I am not aware of the results of those readings). Patient denied emergency transport to hospital, and left the facility about 30 minutes after vaccination with her mother to drive her.
Age: 45.0
Sex: F
Vaccine: COVID19
Symptoms: Injection site erythema, Injection site pruritus, Injection site rash
Clinical narrative: patient stated had redness around injection site for 1 to 2 days after administration. redness went away and then redness/rash returned 1 week later, approximately 2 to 3 inches in diameter. patient stated area had mild itching, but denied warm to touch. Patient stated itching was brief, did not last long.
Age: 16.0
Sex: M
Vaccine: COVID19
Symptoms: Product preparation issue
Clinical narrative: Vial of vaccine reconstituted improperly and administered on 07/08/2021. Patient's mother notified on 07/09/2021 and home visit was conducted on 07/10/2021 to re-vaccinate with appropriate dose of 0.3ml.
Age: 49.0
Sex: M
Vaccine: COVID19
Symptoms: Dyspnoea, Pruritus
Clinical narrative: severe allergic reaction within 10 minutes of the shot being administered.  severe itchiness, some shortness of breath.  Was able to be calmed down by Benadryl
Age: 18.0
Sex: F
Vaccine: COVID19
Symptoms: Throat tightness, Urticaria
Clinical narrative: Patient experienced a hive under her right eye and said her throat felt a little tight but had no difficulty with breathing. two doses of 25mg liquid diphenhydramine was administered at 11:40 am and 11:50 am
Age: 70.0
Sex: F
Vaccine: COVID19
Symptoms: Arthropathy, Pain in extremity
Clinical narrative: Patient called to report on going arm pain, possible inflammation with involvement of rotator cuff.  Patient has seen primary provider who suggested involvement of rotator cuff. Patient and provider are in monitoring mode to see if issue resolves.
Age: 63.0
Sex: F
Vaccine: COVID19, COVID19
Symptoms: Computerised tomogram, Coordination abnormal, Fall, Fatigue, Fibrin D dimer increased
Clinical narrative: I have had neurological symptoms where I lost coordination, tripped, fell, dropped things.  Incredible pain in both legs.  Shooting pain throughout my body.  Extreme fatigue for past 6 weeks,  Tachycardia. Numbness in feet and toes, My whole body has been affected.  My sister in law got her shot at the same time, same lot number, and has almost an identical illness as has her friend, another nurse at The Hospital. She and I were treated similarly.  Steroids and Gabapentin.  I have a diary of all my symptoms that I have documented for about the past 6 weeks.  I went from being a fit, healthy person to a frail woman who can barely walk.
Age: 63.0
Sex: F
Vaccine: COVID19, COVID19
Symptoms: Gait disturbance, Hepatic enzyme abnormal, Hypoaesthesia, Laboratory test, Neurological symptom
Clinical narrative: I have had neurological symptoms where I lost coordination, tripped, fell, dropped things.  Incredible pain in both legs.  Shooting pain throughout my body.  Extreme fatigue for past 6 weeks,  Tachycardia. Numbness in feet and toes, My whole body has been affected.  My sister in law got her shot at the same time, same lot number, and has almost an identical illness as has her friend, another nurse at The Hospital. She and I were treated similarly.  Steroids and Gabapentin.  I have a diary of all my symptoms that I have documented for about the past 6 weeks.  I went from being a fit, healthy person to a frail woman who can barely walk.
Age: 63.0
Sex: F
Vaccine: COVID19, COVID19
Symptoms: Pain, Pain in extremity, Tachycardia
Clinical narrative: I have had neurological symptoms where I lost coordination, tripped, fell, dropped things.  Incredible pain in both legs.  Shooting pain throughout my body.  Extreme fatigue for past 6 weeks,  Tachycardia. Numbness in feet and toes, My whole body has been affected.  My sister in law got her shot at the same time, same lot number, and has almost an identical illness as has her friend, another nurse at The Hospital. She and I were treated similarly.  Steroids and Gabapentin.  I have a diary of all my symptoms that I have documented for about the past 6 weeks.  I went from being a fit, healthy person to a frail woman who can barely walk.
Age: 42.0
Sex: M
Vaccine: COVID19
Symptoms: Arthralgia, Blood pressure increased, Disturbance in attention, Fatigue, Headache
Clinical narrative: Rather intense headache and fatigue night of vaccination, but that was expected.  Since then (from day 2 up till now), persistent headache (dull at the back of the head), neck and shoulder ache.  Very annoying and makes it difficult to think and/or concentrate.   Also having strange inflammation (both in the head and cardiac) and erratic heartbeat, likely contributing to increased blood pressure.
Age: 42.0
Sex: M
Vaccine: COVID19
Symptoms: Heart rate irregular, Inflammation, Neck pain
Clinical narrative: Rather intense headache and fatigue night of vaccination, but that was expected.  Since then (from day 2 up till now), persistent headache (dull at the back of the head), neck and shoulder ache.  Very annoying and makes it difficult to think and/or concentrate.   Also having strange inflammation (both in the head and cardiac) and erratic heartbeat, likely contributing to increased blood pressure.
Age: 73.0
Sex: M
Vaccine: COVID19
Symptoms: Interchange of vaccine products, Pain in extremity
Clinical narrative: Pfizer BioNTech Covid-19 Vaccine Adverse Effect. Upon submitting the completion of his Pfizer vaccine series to the state registry, the Pharmacist on Duty checked to ensure the administration was properly reported.  At this time, he realized the patient had received the Janssen Covid-19 Vaccine on 3/5/21 Lot #1805025. When asked prior to administration if he had received a previous COVID-19 vaccine, the patient denied previously receiving any doses of Covid-19 vaccines.  When the pharmacy manager called to follow up with the patient and inquire about the J&J vaccine, the patient's daughter stated her father didn't speak English and she would have to look for the paperwork and get back to the pharmacy about whether or not he received the J&J vaccine. She stated he was not experiencing any additional side effects beyond a sore arm at this time.
Age: 41.0
Sex: F
Vaccine: COVID19
Symptoms: Immune thrombocytopenia, Platelet count decreased
Clinical narrative: Admitted tp hospital for ITP diagnosed on 7/10/21
Age: 37.0
Sex: F
Vaccine: COVID19
Symptoms: Immunisation, Product preparation issue
Clinical narrative: Vial of vaccine improperly reconstituted and administered on 07/08/2021. Patient contacted on 07/09/2021. Home visit conducted on 07/10/2021 and correct dose of 0.3ml administered.
Age: 75.0
Sex: F
Vaccine: COVID19, COVID19
Symptoms: Deep vein thrombosis, Pain, Ultrasound Doppler abnormal
Clinical narrative: blood clot --dvt---found on april  28 2021-------throbbing in leg....placed on Eliquis  5mg. as of july 10 2021 still taking eliguis ....follow up with doctor on july 21 2021
Age: 46.0
Sex: M
Vaccine: COVID19
Symptoms: Cyanosis, Hypotonia, Immediate post-injection reaction, Loss of consciousness, Mydriasis
Clinical narrative: Patient received the first COVID Pfizer vaccine, left the immunization room, walked to a chair, and sat down. Less than a minute later, patient lost consciousness (not sure if just passed out or had seizure), lips turned blue, was gurgling, pupils were dilated, and went limp. His companion helped me get him to the floor, where he was breathing. He remained unconscious for less than a minute longer. We called 911, who instructed us to leave him on the floor until help arrived. His blood pressure was normal when they arrived and patient refused to be further evaluated in the ambulance and refused to go to the hospital. Patient walked out of the store.
Age: 46.0
Sex: M
Vaccine: COVID19
Symptoms: Speech disorder
Clinical narrative: Patient received the first COVID Pfizer vaccine, left the immunization room, walked to a chair, and sat down. Less than a minute later, patient lost consciousness (not sure if just passed out or had seizure), lips turned blue, was gurgling, pupils were dilated, and went limp. His companion helped me get him to the floor, where he was breathing. He remained unconscious for less than a minute longer. We called 911, who instructed us to leave him on the floor until help arrived. His blood pressure was normal when they arrived and patient refused to be further evaluated in the ambulance and refused to go to the hospital. Patient walked out of the store.
Age: 20.0
Sex: F
Vaccine: COVID19
Symptoms: Immunisation, Product preparation issue
Clinical narrative: Vial of vaccine improperly reconstituted and administered on 07/08/2021. Patient contacted on 07/09/2021. Home visit conducted on 07/10/2021 and correct dose of 0.3ml administered.
Age: 54.0
Sex: F
Vaccine: COVID19
Symptoms: Mobility decreased, Pain in extremity
Clinical narrative: Severe and constant pain in left arm. Extreme loss of motion and use of left arm.
Age: 53.0
Sex: F
Vaccine: COVID19
Symptoms: Autoscopy, Fatigue, Feeling abnormal, Pain
Clinical narrative: (Note: this only pertains to my second shot) In addition to the typical symptoms of feeling tired and achy, I also felt very spacey and out-of-it. I am so thankful that my friend had offered to go with me because I would not have felt safe driving home! The feeling started a few minutes into the standard 15-minute post-shot wait time in the office. At the time, I'd assumed it was just from being anxious about getting the shot, but the feeling lasted the rest of the afternoon. It might sound odd, but at times, I felt like I was having an out-of-body experience. I remember washing the dishes and my arms didn't seem like they belonged to me. The feeling gradually faded away towards the evening, but I still had that spacey feeling occasionally through the next day. Apparently, I am not the only one who's experienced this feeling; when I'd asked a friend about their vaccine experience (also Pfizer, but from a different location), they described the exact same strange feeling. So, I just wanted to make sure I logged my experience.
Age: 32.0
Sex: F
Vaccine: COVID19
Symptoms: Dizziness, Pallor, Syncope, Vomiting
Clinical narrative: Patient became lightheaded, pale, and dizzy several minutes after vaccine. She vomited into a trash can and had fainted into her chair during the minutes following the husband alerting the pharmacy team she was having a reaction (we were there to witness and aid the patient.) After vomiting and having water, the patient recovered quickly.  We monitored her one on one in the vaccine room for about 10 to 15 additional minutes and also took her blood pressure and temperature (both normal.) Patient remarked that she felt completely fine thereafter.
Age: 13.0
Sex: F
Vaccine: COVID19
Symptoms: Interchange of vaccine products
Clinical narrative: THE PATIENT CAME IN TO THE CLINIC ON 07/10/2021 TO RECEIVE THE BOOSTER DOSE OF PFIZER. WHEN DOCUMENTING THE VACCINE, WE NOTICED THAT A MISTAKE ON DOCUMENTING THE FIRST DOSE OF PFIZER WAS DONE. ON THE SYSTEM WAS DISPLAYED THAT THE PATIENT RECEIVED A DOSE OF J&J ON 06/20/2021 INSTEAD OF THE DOSE OF PFIZER THAT SHE ACTUALLY RECEIVED ON THAT DATE.
Age: 32.0
Sex: F
Vaccine: COVID19
Symptoms: Fatigue, Headache, Heavy menstrual bleeding, Myalgia, Oligomenorrhoea
Clinical narrative: Period heavy and lasted 3 weeks, arm pain, muscle soreness all over, headache, tired
Age: 32.0
Sex: F
Vaccine: COVID19
Symptoms: Pain in extremity
Clinical narrative: Period heavy and lasted 3 weeks, arm pain, muscle soreness all over, headache, tired
Age: 55.0
Sex: M
Vaccine: COVID19
Symptoms: Rash
Clinical narrative: Rash on both arms starting about a week after vaccine. Patient went to urgent care and was prescribed antibiotics and prednisone.
Age: 47.0
Sex: M
Vaccine: COVID19
Symptoms: Anxiety, Blood thyroid stimulating hormone, Electrocardiogram normal, Full blood count normal, Injection site pain
Clinical narrative: Received first Covid shot April 6 (same location as the data entered for this one, Pfizer Lot EW0153).   April 10 had uncontrollable muscle spasms in both legs for 5 minutes. Did not seek treatment.  Received second Covid shot April 27.   April 30 had muscle spasms increasing throughout day and anxiety. Did not seek treatment.  Anxiety increased through May 5 when I went to the hospital around 2AM due to muscle spasms, muscle pain, anxiety. In hospital I experienced over 1 hour of constant full body muscle spasms/seizures where all my muscles would tense up uncontrollably over and over. This eventually subsided and I was released. Diagnosis absent any other cause was anxiety.  From May 5 through ~June 11, experienced frequent random muscle spasms and tics mostly in left leg but also encompassing abdominal, lower back, chest and rib pain. Experienced feeling of left arm heaviness through July 3. Arm pain in shot area recurred since the time of the second shot at least six separate times (last July 3).  Was stared on Gabapentin for nerve pain, muscle spasms, anxiety, which eased symptoms. As of July 10 feeling mostly normal, no longer experiencing muscle spasms with any frequency.