Age: 75.0
Sex: F
Vaccine: COVID19, FLUX, COVID19, FLUX
Symptoms: Therapy non-responder
Clinical narrative: Brain tumor; brain cancer; brain lymphoma; No changes in symptoms or breathing overall, however their physical therapy exertion causes pt shortness of breath; fatigued; Intermittent diarrhea; No changes in symptoms or breathing overall, however their physical therapy exertion causes pt shortness of breath; Initial information received on 28-Dec-2023 regarding an unsolicited valid  serious Courtesy case received from a consumer/non-hcp.  This case involves a 75 years old female patient who experienced brain tumor; brain cancer; brain lymphoma, no changes in symptoms or breathing overall, however their physical therapy exertion causes pt shortness of breath, fatigued, intermittent diarrhea and no changes in symptoms or breathing overall, however their physical therapy exertion causes pt shortness of breath after receiving COVID-19 VACCINE and INFLUENZA VACCINE and while treated with TREPROSTINIL SODIUM.  The patient's past medical history, medical treatment(s), vaccination(s) and family history were not provided. At the time of the event, the patient had ongoing Pulmonary arterial hypertension.   On an unknown date, the patient started taking TREPROSTINIL SODIUM Injection at a dose of 0.2 ug/kg subcutaneous (with an unknown expiry date, batch number) for Pulmonary arterial hypertension. On an unknown date, the patient received a unknown dose of suspect INFLUENZA VACCINE produced by unknown manufacturer (formulation, strength, expiry date, lot number not reported) via unknown route in unknown administration site for prophylactic vaccination (Immunization). On an unknown date, the patient received a  dose of suspect COVID-19 VACCINE not produced by Sanofi Pasteur lot number not reported via unknown route in unknown administration site for COVID-19 immunization.  In 2023 the patient developed a serious brain tumor; brain cancer; brain lymphoma (central nervous system lymphoma), no changes in symptoms or breathing overall, however their physical therapy exertion causes pt shortness of breath (dyspnoea exertional) , fatigued (fatigue) and diarrhea (diarrhoea) and  no changes in symptoms or breathing overall, however their physical therapy exertion causes pt shortness of breath (therapy non-responder) (unknown latency) following the first dose intake and (unknown latency) following the last dose intake of TREPROSTINIL SODIUM and following the administration of INFLUENZA VACCINE and (unknown latency) following the administration of COVID-19 VACCINE.   Relevant laboratory test results included: Echocardiogram - On an unknown date:  [Cardiac and other pressure issues are doing better and pressure looked like it was holding in the 60's, not worsening]  Action taken with TREPROSTINIL SODIUM (TREPROSTINIL SODIUM) was unknown. Action taken with INFLUENZA VACCINE (INFLUENZA VACCINE) and COVID-19 VACCINE (COVID-19 VACCINE) was not applicable.  It was not reported if the patient received a corrective treatment for the events (Brain tumor; brain cancer; brain lymphoma, No changes in symptoms or breathing overall, however their physical therapy exertion causes pt shortness of breath, No changes in symptoms or breathing overall, however their physical therapy exertion causes pt shortness of breath, fatigued, Intermittent diarrhea).  At time of reporting, the outcome was Unknown for all the events.  Seriousness Criteria : Medically significant and hospitalization for all the events.; Sender's Comments: Sanofi Company Comment dated 05-Jan -2024 : This case involves a 75 years old female patient who experienced brain tumor; brain cancer; brain lymphoma, no changes in symptoms or breathing overall, however their physical therapy exertion causes pt shortness of breath, fatigued, intermittent diarrhea and no changes in symptoms or breathing overall, however their physical therapy exertion causes pt shortness of breath after receiving COVID-19 VACCINE and INFLUENZA VACCINE and while treated with TREPROSTINIL SODIUM.Further information regarding allergic history excluding alternative etiologies for the reported events are needed to fully assess this case. Based upon the reported information, the role of a vaccine cannot be assessed. Further, the patient medical history would be cofounding factor for this events.