Age: 80.0
Sex: F
Vaccine: VARZOS, VARZOS, VARZOS, VARZOS
Symptoms: Ophthalmic herpes zoster, Pain in extremity, Walking aid user
Clinical narrative: Difficulty walking; caused the eye epithelia to go off; had to use her cane; Suspected vaccination failure / Herpes Zoster in her left eye; Herpes Zoster in her left eye; Awful pain in left eye; This serious case was reported by a consumer via call center representative and described the occurrence of vaccination failure in a 80-year-old female patient who received Herpes zoster (Shingrix) for prophylaxis.   Co-suspect products included Herpes zoster (Shingrix) for prophylaxis.   The patient's past medical history included cancer. Concurrent medical conditions included graft versus host disease (diagnosed a year ago before the Shingrix vaccination. This disease affected patient's left eyes, and it was under control).   On 03-DEC-2023, the patient received the 2nd dose of Shingrix. On an unknown date, the patient received the 1st dose of Shingrix. On 15-JAN-2024, 43 days after receiving Shingrix and an unknown time after receiving Shingrix, the patient experienced vaccination failure (Verbatim: Suspected vaccination failure / Herpes Zoster in her left eye) (serious criteria GSK medically significant), ophthalmic herpes zoster (Verbatim: Herpes Zoster in her left eye) (serious criteria GSK medically significant) and eye pain (Verbatim: Awful pain in left eye). On an unknown date, the patient experienced walking difficulty (Verbatim: Difficulty walking), corneal erosion (Verbatim: caused the eye epithelia to go off) and cane user (Verbatim: had to use her cane). The outcome of the vaccination failure, ophthalmic herpes zoster, walking difficulty and corneal erosion were unknown and the outcome of the eye pain was not resolved and the outcome of the cane user was not reported.   The reporter considered the vaccination failure and ophthalmic herpes zoster to be possibly related to Shingrix and Shingrix. It was unknown if the reporter considered the eye pain, walking difficulty, corneal erosion and cane user to be related to Shingrix and Shingrix.     The company considered the vaccination failure and ophthalmic herpes zoster to be possibly related to Shingrix and Shingrix. It was unknown if the company considered the eye pain, walking difficulty, corneal erosion and cane user to be related to Shingrix and Shingrix.   Additional Information: GSK Receipt Date: 22-FEB-2024 The patient self-reported this case. The patient received her second shot of Shingrix and started having an awful pain in her left eye. The patient initially thought that the pain was related to the Graft Versus Host Disease (GVHD) condition. The patient visited doctor who stated she had Herpes Zoster in her left eye that was causing the awful pain. The patient reported days after the pain started and she could not walk and had to use her cane the pain got worse. The patient was put on antivirals and antibiotic medications for 10 days and was advised to stop the medications for Graft Versus Host Disease which aggravated the pain in the eye. The patient strongly believed the Herpes Zoster was caused by the Shingrix vaccination. According to the patient, the Herpes Zoster in her left eye caused the eye epithelia to go off. This case was considered as suspected vaccination failure since the details regarding laboratory test confirming shingles were unknown at the time of reporting.  The reporter did not consent to follow-up.