Age: 46.0
Sex: F
Vaccine: COVID19, COVID19
Symptoms: Chest discomfort, Depression, Dizziness, Dyspnoea, Headache
Clinical narrative: depressed thinking she; chest tighten; my heart raced; I couldn't breathe and had to remove my mask and try to deep breathe; I stood and felt dizzy, then sat and continued deep breathing; neck swelled at thyroid that night; my throat was itchy/sore; my throat was itchy/sore; headache; quite a few allergies; This is a spontaneous report from a contactable healthcare professional (patient). A 46-year-old non-pregnant female patient received BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE, lot number: ER8735) at the age of 46-years-old, via an unspecified route of administration in right arm on 01May2021 at 1st dose, single for COVID-19 immunization. Medical history included Ehlers Danlos, a connective tissue disorder. It is genetic but it also impacts one part of the immune system. The patient has not been diagnosed with this additional part because they did not think it was useful to go for a million tests for something that they have, then not going to treat them any differently. This goes with mast cell activation disorder and a lot of people with Ehlers Danlos have mast cell activation disorder. It causes a lot of allergic reactions to a lot of things. The patient then clarified that she has not been diagnosed with mast cell activation because it was not useful to go for a million tests. If the patient takes a medication, she gets an anaphylactic-like reaction. She has a lot of history with allergies to drugs. For family history, mast cell activation disorder, if people looked at concomitant conditions that go with mast cell activation disorder, her family history has every single one of those. This includes rheumatoid arthritis, Ehlers Danlos, bladder frequent urination issues, and they all have that. Also, multiple sclerosis. Also, gives like just getting hives. Her sister gets hives and reacts to the sun - she breaks out in hives. The list goes on with mast cell activation disorder and goes with Ehlers Danlos together with all of these big huge lists. Everyone in her family was represented on the whole list. Prior to vaccination, the patient was not diagnosed with COVID-19. Concomitant medications included levothyroxine, famotidine, cyanocobalamin (B12), ascorbic acid (C VITAMIN), colecalciferol (D3 VITAMIN), magnesium, and thiamine hydrochloride (B1 VITAMIN). She did not receive any other vaccines within 4 weeks prior to the COVID vaccine. The patient has a lot of history with allergies to drugs and she has had reactions following previous vaccinations: in 2009, for the H1N1 pandemic, she got the vaccine for immunization and then she had Bell's Palsy. After that, she got an autoimmune disease which may or may not have been due to the vaccine. She did not remember what year it was she got the varicella vaccine for immunization and she experienced a racing heart and could not breathe, and she had to sit in the emergency room. A year ago (2020), she got the tetanus vaccine for immunization and had no reaction. She has had multiple other vaccinations too where nothing happened, and she has had lots of vaccines, so she was not scared of them. The facility where the most recent COVID-19 vaccine was administered was at a pharmacy or drug store. Since the vaccination, the patient has not been tested for COVID-19. On 01May2021 at 15:30 (also reported as within 30 seconds of receiving the dose), the patient felt her chest tighten, heart raced, and couldn't breathe; she had to remove her mask and tried to breathe deeply. When she stood up, she felt dizzy, then she sat and continued deep breathing. She mentioned that this scary part lasted for 5 minutes then diminished over the next half hour. She was offered antihistamine and they were ready with the epi-pen, but she didn't need it. She mentioned that on 01May2021, yer neck swelled at thyroid that night, and her throat was itchy/sore. The patient took two BENADRYL. She still has headache, but everything else mostly resolved. She had quite a few allergies after vaccination which was non-serious.  Her sister had the same reaction and they have the same conditions. Her sister's reaction was different in that her sister's face swelled. The patient's reaction was that her heart raced, and she could not breathe. Both she and her sister were fine, but she did not think she could get the second vaccine unless she could get it in a more supervised state. The patient and her sister have Ehlers Danlos, which was a connective tissue disorder. It is genetic but it also impacts one part of the immune system. A lot of people with Ehlers Danlos have mast cell activation disorder. It causes a lot of allergic reactions to a lot of things. She was thinking if she could take a mast cell inhibitor, she could take the second vaccine dose to see if she does not have the reaction. She understood that they did not want people to do that, because they will have a diminished response. But, if it was between her not getting the second dose or maybe other people could get it and have lesser response and still get the second vaccine, it just seemed like something easy if Pfizer could just come up with a plan where she will get the second dose and see if she does not have that reaction. Yesterday, she was depressed thinking she could not get the second vaccine. The CDC said do not get the second dose if someone had a reaction. The patient mentioned that her heart rate was still a little weird the entire time. After five minutes, she thought okay maybe she will be fine. The first minutes or so, she thought maybe they will have to call 911 but it worked out. You never know with that allergic reaction stuff. She mentioned that her previous reaction with varicella vaccine was worse, the same thing as this was, but lasted longer than the COVID vaccine. She felt like the racing was longer and she could not breathe for a longer time, but it was similar. It was the live virus, she guessed she let it go because it was a live virus. She did not visit an emergency room of physician's office because she had these things happen to her before. Because she has experienced these things before, she did not get panicky and she just tried to breathe it out and see what happened. The kid that was attending her asked if she wanted him to call an ambulance and she said no, she was just going to wait and see if the breathing thing goes away and it did. Deep breathing helped it go away, she did not know why, but it just does. Her second dose was due for 22May2021. The outcome of the event "headache" was not recovered, recovered on May2021 for "neck swelled at thyroid that night", "my throat was itchy/sore", and "quite a few allergies", and recovered on 01May2021 for all other events.