Sex: F
Vaccine: COVID19, FLUX
Symptoms: Muscle spasms, Neck pain, Pain in extremity, Rash pruritic, Sleep disorder due to general medical condition, insomnia type
Clinical narrative: Fungal infection/Yeast infection; abdominal pain upper/severe pain after the dupixent injection in stomach); muscle spasms/cramping in hands; eczema/minor eczema breakouts on her back; pain in extremity/Pain in hands; Rash pruritic/she had a patch on the back of her neck that itched; neck pain/neck pain that travel down her neck; urinary tract infection; insomnia/unable to sleep because of dental procedure; Dental operation/Dental procedure; Injection site pain/has experienced pain at the injection site after her last two doses; This is a spontaneous report received from a Consumer or other non HCP. Other Case identifier(s): 2022SA520984.  An 85-year-old female patient (not pregnant) received BNT162b2 (BNT162B2 NOS), as dose number unknown, single (Batch/Lot number: unknown) for covid-19 immunisation; dupilumab (DUPIXENT), first regimen since Feb2022) at 300 mg (300 mg (first dose)), subcutaneous and second regimen) at unk (second dose) for dermatitis atopic; influenza vaccine (INFLUENZA VACCINE), as dose number unknown, single) for immunisation. The patient's relevant medical history and concomitant medications were not reported. The following information was reported: INJECTION SITE PAIN (non-serious) with onset 2022, outcome "unknown", described as "Injection site pain/has experienced pain at the injection site after her last two doses"; DENTAL OPERATION (non-serious) with onset 19Aug2023, outcome "unknown", described as "Dental operation/Dental procedure"; SLEEP DISORDER DUE TO GENERAL MEDICAL CONDITION, INSOMNIA TYPE (non-serious) with onset 21Aug2023, outcome "unknown", described as "insomnia/unable to sleep because of dental procedure"; NECK PAIN (non-serious) with onset 21Aug2023, outcome "unknown", described as "neck pain/neck pain that travel down her neck"; URINARY TRACT INFECTION (non-serious) with onset 21Aug2023, outcome "unknown"; RASH PRURITIC (non-serious) with onset Aug2024, outcome "unknown", described as "Rash pruritic/she had a patch on the back of her neck that itched"; FUNGAL INFECTION (non-serious), outcome "unknown", described as "Fungal infection/Yeast infection"; ABDOMINAL PAIN UPPER (non-serious), outcome "unknown", described as "abdominal pain upper/severe pain after the dupixent injection in stomach)"; MUSCLE SPASMS (non-serious), outcome "unknown", described as "muscle spasms/cramping in hands"; ECZEMA (non-serious), outcome "recovered" (2024), described as "eczema/minor eczema breakouts on her back"; PAIN IN EXTREMITY (non-serious), outcome "unknown", described as "pain in extremity/Pain in hands". The action taken for dupilumab was unknown. Therapeutic measures were taken as a result of fungal infection, urinary tract infection.  Additional information: On an unknown date in 2022 the patient developed a non-serious event has experienced pain at the injection site after her last two doses unknown latency following the first dose intake of Dupilumab. On an unknown date the patient developed non-serious events Injection site pain (unknown latency), Yeast infection (unknown latency), Abdominal pain upper (unknown latency), Hand pain (unknown latency), Cramp in hand (unknown latency), Eczema (unknown latency), on 21Aug2023 Neck pain (latency 1 year 6 months approximately), on 21Aug2023 Urinary tract infection (latency 1 year 6 months approximately), on 21Aug2023 Insomnia (latency 1 year 6 months approximately), on 19Aug2023 Dental operation (latency 1 year 6 months approximately) following the first dose intake of Dupilumab. On an unknown date in Aug2024, the patient developed a non-serious event 'reported having a flare of her eczema. She also reported 1 small flare up on her arm about 6 weeks ago (eczema)' and she had a patch on the back of her neck that itched (rash pruritic) (latency 2 years 6 months approximately) following the first dose intake (unknown batch number and expiry date) of dupilumab, COVID-19 vaccine and influenza vaccine. It was reported the patient reported that she has experienced pain at the injection site after two doses. Patient developed yeast infection and had severe pain after the Dupixent injection in her stomach, also reported pain in the hands. The patient will miss one dose of Dupixent due to the weather outside and when she was able to get into the doctor's office to have them administer her dose. It was unknown if there were lab data/results available. On follow-up, it was reported she was currently using nystatin cream for infection but reported that symptoms were minor. Patient reported neck pain that travels down her neck that started yesterday after her dental procedure 2 days ago. She stated she never experienced this pain before and she thought it could be the dental procedure, stated she was unable to sleep because of it. She then stated she was diagnosed with a UTI on Monday and was finishing her abx (antibiotics). Patient also stated she has on and off yeast infections and she used Monostat. Patient reported having a flare of her eczema after receiving the COVID and fly shots. She had a patch on the back of her neck that itched. She also reported 1 small flare up on her arm about 6 weeks ago. Both flares have resolved. Action taken with all suspects was unknown for all events. Corrective treatment: The patient was treated with Nystatin and Monostat for yeast infection; Antibiotics for UTI and not reported for other events. Outcome: recovered/resolved on an unknown date in 2024 for event eczema and unknown for other events. Case was non-serious. Case listedness: Unlisted. Case outcome: Unknown.  No follow-up attempts are possible. Batch/lot number is not provided, and it cannot be obtained.