Sex: M
Vaccine: COVID19
Symptoms: Biopsy, Diffuse large B-cell lymphoma, Fatigue, Investigation, Lymphadenopathy
Clinical narrative: swelling of lymph nodes; fatigue; vomiting; large diffuse B-cell lymphoma; This is a spontaneous report received from a Consumer or other non HCP from medical information team.  A 66-year-old male patient received BNT162b2 omicron (kp.2) (COMIRNATY (2024-2025 FORMULA)), on 05Sep2024 as dose 1, single (Batch/Lot number: unknown) for covid-19 immunisation. The patient's relevant medical history included: "asthmatic" (unspecified if ongoing); "Chronic lymphocytic leukemia" (unspecified if ongoing). The patient's concomitant medications were not reported. Vaccination history included: comirnaty (2023-2024 formula) (DOSE 6 (BOOSTER), SINGLE), administration date: 08Jun2024, for COVID-19 immunization, reaction(s): "large diffuse B-cell lymphoma", "swelling of lymph nodes", "fatigue", "vomiting"; Bnt162b2 (DOSE 5 (BOOSTER), SINGLE), for Covid-19 immunization; Bnt162b2 (DOSE 4 (BOOSTER), SINGLE), for Covid-19 immunization; Bnt162b2 (DOSE 3 (BOOSTER), SINGLE), for Covid-19 immunization; Bnt162b2 (DOSE 2, SINGLE), for COVID-19 immunization; Bnt162b2 (DOSE 1, SINGLE), for COVID-19 immunization. The patient had booster doses of Pfizer COVID-19 Vaccines on 08Jun2024 and 05Sep2024 the new formulation 2024-2025 reported that after the booster shot her husband experienced swelling of lymph nodes, fatigue and vomiting (Sep2024). The patient who is 66 years old and is asthmatic with CLL (Medical history), as he has been taking the boosters (Pfizer COVID-19 Vaccine), including one that he took on 08Jun2024 and another one on 05Sep2024, the new one just came out, as he is taking these, his lymph nodes are swelling. The reported called to find out. The patient was having such strong reactions to the booster that he will need to be in bed and can be vomiting, too fatigued to function for about 36 hours or so at a time. Patient has recently been to a doctor, and they had him do a booster that just came out and they are concerned that his CLL (Chronic lymphocytic leukemia) maybe transforming into diffused B-cell lymphoma but his tests keep coming back as inconclusive including a biopsy of one of his very swollen lymph nodes but it turned out were three matted lymph nodes upon the biopsy. Even a PET scan came back is inconclusive for a true lymphoma diagnosis. The patient had multiple diagnostic tests these tests were inconclusive to confirm diagnosis and wanted to confirm if her husband's response to covid-19 vaccine may be a factor. Husband was recommended for chemotherapy.  The patient got Pfizer COVID-19 Vaccines ever since and it was his 7th booster, patient is an immunocompromised patient. Reporter would like to know if the vaccine maybe contributing to patient symptoms because it has been transforming. The outcome for the events large diffuse B-cell lymphoma, swelling of lymph nodes, fatigue and vomiting was unknown.  The information on the batch/lot number for BNT162b2 omicron (kp.2) will be requested and submitted if and when received.; Sender's Comments: Linked Report(s) : US-PFIZER INC-202400256707 same patient/reporter/drug/events, different dose number;