Sex: M
Vaccine: COVID19
Symptoms: Full blood count abnormal, Headache, Interchange of vaccine products, Mobility decreased, Muscular weakness
Clinical narrative: Death; Cerebral venous sinus thrombosis; Thrombocytopenia; Platelet count decreased; Cerebral Haemorrhage; Cerebrovascular accident; Pupil fixed; Mobility decreased; Dysarthria; Muscular weakness; Headache; Angiogram cerebral abnormal; Computerised tomogram head abnormal; Full blood count abnormal; Interchange of vaccine products; This is a spontaneous report received from contactable reporter(s) (Other HCP) from Regulatory Authority VAERS. Other Case identifier(s): 20211240996(0).  A 48 year-old male patient received bnt162b2 (BNT162B2), administration date 28Feb2021 (Lot number: EL9266) as dose 2, single for covid-19 immunisation; janssen covid-19 vaccine (JANSSEN COVID-19 VACCINE), intramuscular, administered in arm left, administration date 04Aug2021 (Lot number: 041A22A) for covid-19 immunisation. Relevant medical history included: "Hypertension" (ongoing); "Dyslipidemia" (ongoing). Concomitant medication(s) included: VALSARTAN; ROSUVASTATIN. Patient didn't have any allergies. Vaccination history included: Bnt162b2 (First Dose, Lot number: EL8982), administration date: 20Jan2021, for COVID-19 Immunization.  On 16Aug2021 in morning, the patient had headache, then over hours of couple hours developed hand weakness (muscular weakness) then 1-2 hours later developed slurred speech and could not lift arm. This was highly suspicious for a side effect of the vaccine and the patient needed higher level of care and the facility was unable to take patient. The patient was sent via helicopter. The was awake and responsive at time of transfer. Helikopter transfer patient for neurosurgery and was consulted and had posturing in route and fixed dilated pupil intubated in route. Patient was admitted to emergency room. The patient was hospitalized for 1 day. Venous phase images demonstrate thrombus within superior sagittal sinus. There was contrast extravasation on the venous images within the areas of right frontal hemorrhage. There was a 26 x 13 cm right frontal parenchymal hemorrhage. More superiorly there was a 9mm right frontal parenchymal hemorrhage with similar sized left frontal parenchymal hemorrhage. This was consistent with active hemorrhage within the areas of venous infarct and stroke cerebral venous sinus thrombosis was diagnosed at facility on arrival (Cerebral hemorrhage, cerebrovascular accident) with thrombocytopenia, patient's mobility was decreased, had dyasthria, endotracheal intubation, pupil fixed and angiogram cerebral was abnormal. Computorised tomogram head showed multiple small bleeds(CVST), computed tomography angiography was done and no aneyusm but patient did have a cavernous sinus thrombosis and subsequent bleeding, full blood count was abnormal (showing thrombocytopenia), platelet count was decreased to 48, sars-cov-2 test was negative. On 17Aug2021, the patient died from unspecified cause of death at facility. It was unknown whether autopsy was performed. The patient died of unknown cause of cerebral hemorrhage, cerebrovascular accident, thrombocytopenia, mobility decreased, dysarthria, endotracheal incubation, pupil fixed, angiogram cerebral abnormal, computorised tomogram head abnormal, full blood count abnormal, interchange of vaccine products, platelet count decreased, sars-cov-2 test negative, cerebral venous sinus thrombosis, muscular weakness and headache on 17Aug2021 (as reported). This report was serious (Death and hospitalization caused/Prolonged). Covid-19 vaccine with cerebral venous sinus thrombosis, thrombocytopenia, platelet count decreased: This event (s) is per reporter is therefore considered potentially related. Covid-19 vaccine with Death, cerebral haemorrhage, cerebrovascular accident, mobility decreased, dysarthria, endotracheal intubation, pupil fixed, angiogram cerebral abnormal, computerised tomogram head abnormal, full blood count abnormal, interchange of vaccine products,  muscular weakness and headache: This event(s) is considered unassessable. The event(s) has a compatible/suggestive temporal relationship, is unlabeled, and has unknown scientific plausibiIity. There is no on any other factors potentially assaciated with the event (s). Causality per reporter and per Manufature for all events was possible.; Reported Cause(s) of Death: Cerebral venous sinus thrombosis; Thrombocytopenia; Platelet count decreased; Cerebral haemorrahge; Cerebrovascular accident; Pupil fixed; Mobility decreased; Dysarthria; Muscular weakness; Headache; Angiogram cerebral abnormal; Comuterised tomogram