Age: 1.0
Sex: F
Vaccine: MMR
Symptoms: Pyrexia, Seizure, Staring, Unresponsive to stimuli, Viral test negative
Clinical narrative: croup; hada febrile seizure; fever of 101.1; she wasn't moving; in a staring state; unresponsive; loses half her brain; Complex partial seizures; Tonic-clonic (TC) seizures; suddenly began to seize / she had seizures about every month, and they began to get worse; acting strangely; low-grade fever; normal fussy period; she began to seem a little off, not as responsive; she began to seem a little off; This spontaneous report was received from a consumer, who was the patient's mother and who shared a story of her 2-year-old daughter via an online article published on a website. It was reported that the patient developed just like all children in her age and hit her milestones on or before the target age. Her historical vaccines included diphtheria toxoid (+) hepatitis B virus vaccine rHBsAg (yeast) (PEDIARIX) (reported as PEDIAX), diphtheria toxoid (+) pertussis acellular vaccine (unspecified) (+) tetanus toxoid (reported as DTaP) and another unspecified combination of vaccines. Diphtheria toxoid (+) pertussis acellular vaccine (unspecified) (+) tetanus toxoid vaccine caused fussy period (reported as normal) in the patient's behaviour. The patient's parents decided to do vaccines one at a time on a delayed schedule.  On 12-JUN-2012, the patient was vaccinated with the first dose of measles, mumps, and rubella (wistar ra 27-3) virus vaccine, live (M-M-R II) injection (dose, route of administration, lot number and expiration date were not reported). On an unknown date in June 2012, after the vaccination, she had the normal fussy period, but after a week, she began to seem a little off, not as responsive and she continued to be fussy. On 27-JUN-2012, she experienced low-grade fever. On 28-JUN-2012, the parent noticed that she was not moving and was in a staring state, unresponsive. The patient was taken to the emergency room (ER), where, after 30 minutes, the doctor confirmed she was having a seizure and had a fever of 101.1 (units not provided). The patient had unspecified tests performed, which did not show viral or bacterial infection. The patient was transferred to the Hospital, where she spent the night for observation. The doctor said that she had a febrile seizure. On 01-NOV-2012, the patient woke up acting strangely and then suddenly began to seize. She was administered diazepam (DIASTAT) as treatment. She woke up an hour later and got another seizure. The parents took her to the Hospital, where she was diagnosed with croup. Beginning on an unknown date in December 2012, the patient had seizures about every month and they began to get worse. Instead of having partial complex seizures, she began to have partial complex that generalized and tonic-clonic seizures. By unknown date in April 2013, she was having seizures every week, and in the middle of April 2013, had three major tonic-clonic seizures within a week's time. On an unknown date, she experienced brain damage (reported as "loses half a brain").   The outcome of the events and relatedness between the events and measles, mumps, and rubella (wistar ra 27-3) virus vaccine, live (M-M-R II) were not reported.   Upon internal review, the events of unresponsive to stimuli, croup, seizure, generalised tonic-clonic seizure, complex partial seizures and brain damage were determined to be medically significant.  This is one of two reports from the same source.; Sender's Comments:  US-009507513-1910USA014612: