Sex: M
Vaccine: VARZOS, VARZOS
Symptoms: Herpes zoster, Neuralgia, Pain in extremity, Post herpetic neuralgia, Skin lesion
Clinical narrative: Still has nerve pain goes down both legs to toes; Two lesions on one thigh and one lesion on the other thigh; 2 shots in 2019, then shingles a month ago/suspected vaccination failure; Developed shingles; This serious case was reported by a consumer via call center representative and described the occurrence of vaccination failure in a 58-year-old male patient who received Herpes zoster (Shingrix) for prophylaxis.   Co-suspect products included Herpes zoster (Shingrix) for prophylaxis.   The patient's past medical history included shingles (patient had history of several cases of internal shingles prior to Shingrix vaccine). Concurrent medical conditions included diabetes and immunocompromised.   In APR-2019, the patient received the 2nd dose of Shingrix (left arm). In FEB-2019, the patient received the 1st dose of Shingrix (left arm). In MAR-2023, more than 2 years after receiving Shingrix and Shingrix, the patient experienced vaccination failure (Verbatim: 2 shots in 2019, then shingles a month ago/suspected vaccination failure) (serious criteria GSK medically significant), shingles (Verbatim: Developed shingles) and skin lesion (Verbatim: Two lesions on one thigh and one lesion on the other thigh). On an unknown date, the patient experienced post herpetic neuralgia (Verbatim: Still has nerve pain goes down both legs to toes). The outcome of the vaccination failure was unknown and the outcome of the shingles was not reported and the outcome of the post herpetic neuralgia was not resolved and the outcome of the skin lesion was resolved.   It was unknown if the reporter considered the vaccination failure, shingles, post herpetic neuralgia and skin lesion to be related to Shingrix and Shingrix.     It was unknown if the company considered the vaccination failure, shingles, post herpetic neuralgia and skin lesion to be related to Shingrix and Shingrix.   Additional Information: GSK receipt date: 20-Apr-2023 and 21-Apr-2023 The reporter reported that the patient is diabetic and had a history of several cases of internal shingles prior to receiving both Shingrix vaccines. The patient received two doses of Shingrix on left arm. The patient had no issue since second dose and no flair ups of shingles until my wedding 1 month ago. The reporter reported that the patient developed a case of shingles about 1 month ago in March 2023. The reporter reported that patient had two lesions on one thigh and one lesion on the other thigh. The lesion had resolved now and still had a nerve pain that goes down to both legs to toes. The patient was reading about vaccine lifespan, as patient was diabetic. The patient was wondering about effectiveness of the vaccine for diabetic and the immune compromised. The patient would like to get a third shot, but my pharmacy had issue with this and they quote CDC guidelines. The patient found online comment about the vaccine being 89 percent effective for healthy adults 70 and older after 4 years. The patient would love to have on this and the chance or renewing my vaccine. This case was considered as vaccination failure since the details regarding laboratory confirmation of shingles were unknown at the time of reporting.