Age: 0.34
Sex: F
Vaccine: DTAPHEPBIP
Symptoms: Pyrexia, Retching, Screaming, Slow response to stimuli, Speech disorder developmental
Clinical narrative: Infant had high-pitched screaming all evening/night and was inconsolable. Fever spiked to 105.7 night of vaccine administration. Infant became lethargic, glassy-eyed, appeared to be starting a seizure with unblinking stare and tongue-rolling movements although no generalized seizure activity was noted. Spoke with on-call physician 3 times that night and was advised to continue routine Tylenol and cool baths and bring infant to office in AM.  The following morning, infant was seen in Dr office where blood work was done. Was told to return to office if fever did not improve. Fever then continued to be 102 or above for 10 days following. This resulted in two more office visits where blood work, nasal cultures, xrays, and catheterization for urine cultures were completed. All tests were inconclusive. At 10 days post vaccination, fever broke.  By this time, we were having trouble bottle-feeding. Infant appeared to be unable to latch properly, would become frustrated and scream for hours. Syringe fed infant for several weeks, because she was unable to latch enough to feed completely. Multiple phone calls to office resulted in advice to "just keep doing what you're doing." Infant stopped lifting her head and quit rolling over or sitting - things she had been doing well prior to vaccination. Noticed that her gaze was often directed downward, and she was slow to look towards the sound of your voice. Her facial expressions were now blank most of the time, and we could no longer get her to smile frequently. She also could no longer sit without being VERY supported, whereas prior to vaccine she was close to sitting on her own. Also, began to notice when infant was lifted, she would turn her feet inward (similar to decorticate posturing). She also started having sensory issues, in such as, she could no longer sleep during the day because every little noise and light would wake her up screaming, and she could no longer soother herself. She would scream and scream until she would vomit. I STARTED swaddling, covering the windows, and using white noise to help her sleep during the day. These issues were pointed out to physician multiple times, but nothing was every done. Was told "Sometimes, infants go through little regressions, we'll keep an eye on her." She has had delayed development and feeding issues ever since, and has currently been scored at 6 months behind her real age. She has global hypotonia and unrefined gross/fine motor skills. She did not sit or crawl until 10.5 months. She began pulling to stand around 11 months. At 16 months, she still does not stand alone, walk, talk, or feed herself. Only with much effort have we been able to keep her from the failure-to-thrive range. She gags, vomits, and has trouble swallowing her foods. We still grind most of her foods, especially meats. Standing, crawling, and cruising along the furniture are very slow and uncoordinated. At 15 months, we finally received referrals for therapy, Neurology, and Orthopedics. Ortho has prescribed braces for her legs. Therapy is providing physical therapy, occupational therapy, speech therapy, and developmental specialist. We have not yet seen Neurology to date.