Age: 68.0
Sex: M
Vaccine: COVID19, COVID19, COVID19, COVID19
Symptoms: Amnesia, COVID-19, Electroencephalogram, Magnetic resonance imaging, SARS-CoV-2 test
Clinical narrative: Patient tested positive for COVID-19; In the middle of Feb2022 all of a sudden one day caller couldn't remember anything back to 01Nov2021/memory is still affected; This spontaneous case was reported by a patient and describes the occurrence of COVID-19 (Patient tested positive for COVID-19) and AMNESIA (In the middle of Feb2022 all of a sudden one day caller couldn't remember anything back to 01Nov2021/memory is still affected) in a 68-year-old male patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 005M21A, 036A21A and 010M20A) for COVID-19 vaccination.    Co-suspect product included non-company product TOZINAMERAN (PFIZER BIONTECH COVID-19 VACCINE) for an unknown indication.    Previously administered products included for Product used for unknown indication: Flu vaccine (Patient thought it was Flucelvax and was given on left arm) in September 2021. Past adverse reactions to the above products included No adverse event with Flu vaccine. Concurrent medical conditions included Smoker.   On 03-Feb-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 03-Mar-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 28-Oct-2021, the patient received third dose of TOZINAMERAN (PFIZER BIONTECH COVID-19 VACCINE) (unknown route) 1 dosage form. On 12-Apr-2022, received fourth dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 22-Feb-2022, the patient experienced AMNESIA (In the middle of Feb2022 all of a sudden one day caller couldn't remember anything back to 01Nov2021/memory is still affected). On 27-Mar-2022, the patient experienced COVID-19 (Patient tested positive for COVID-19). The patient was treated with MEMANTINE on 15-Apr-2022 for COVID-19 treatment, at a dose of 1 pill for first week; MEMANTINE for COVID-19 treatment, at a dose of 2 pills for second week; MEMANTINE for COVID-19 treatment, at a dose of 3 pills for third week and MEMANTINE for COVID-19 treatment, at a dose of 4 pills for fourth week. At the time of the report, COVID-19 (Patient tested positive for COVID-19) outcome was unknown and AMNESIA (In the middle of Feb2022 all of a sudden one day caller couldn't remember anything back to 01Nov2021/memory is still affected) had not resolved.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On 15-Mar-2022, Electroencephalogram: caller was clear Caller was clear. On 15-Mar-2022, Magnetic resonance imaging: caller was clear Caller was clear. On 27-Mar-2022, SARS-CoV-2 test: positive (Positive) Positive.         Patient had Memantine for Covid fog.Patient took a 4 week course of that drug and had no good effects from that drug, The drug just made patient more sleepy.Patient took Doses as 1 pill the first week, 2 pills the second week, 3 pills the third week, 4 pills the fourth  week, 70 pills total that the patient was prescribed,patient thought the dose was  0.5mg but not sure.  Patient received Pfizer vaccine as first booster dose with Moderna vaccine. Batch number for Pfizer was reported as 32030BD or WAGS17885.  Patient received second booster dose of Moderna on 12 Apr 2022.  Patient had tested negative for COVID-19 periodically until 27Mar-2022, even when caller lost his memory in Feb2022, he was still negative. Patient reported in the middle of Feb2022 all of a sudden one day, patient couldn't remember anything back to 01-Nov-2021. Had to rebuild his life, went back and read all of his texts and emails to catch up on things caller couldn't remember. Patient got lost like a mile from where patient lives and he has lived in the area for 30 years. Getting lost was the tip off that something was wrong. Patient had problem when he got lost in his neighborhood driving and couldn't remember where he was. In the middle of Feb2022 all of a sudden one day, Got lost in the car 22Feb2022, doesn't remember how many days before getting lost in the car that caller realized he couldn't remember anything. Getting lost in the car is when caller realized he needed to escalate this. Memory was still affected.   Company Comment : This spontaneous case concerns a 68 year-old male patient, with no relevant medical history reported, who experienced the unexpected, non-serious Adverse Event of Special Interest of COVID-19,  which occurred 16 days before a dose of mRNA-1273 vaccine administration, given as the second booster dose. The event occurred 150 days after a dose of Comirnaty, given as the first booster dose (Interchange of vaccine products). Patient was previously vaccinated with 2 doses of mRNA-1273 vaccine as primary series. The ongoing COVID-19 pandemic could be a confounder for the event. The outcome of the event was reported as unknown. The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report.; Sender's Comments: This spontaneous case concerns a 68 year-old male patient, with no relevant medical history reported, who experienced the unexpected, non-serious Adverse Event of Special Interest of COVID-19,  which occurred 16 days before a dose of mRNA-1273 vaccine administration, given as the second booster dose. The event occurred 150 days after a dose of Comirnaty, given as the first booster dose (Interchange of vaccine products). Patient was previously vaccinated with 2 doses of mRNA-1273 vaccine as primary series. The ongoing COVID-19 pandemic could be a confounder for the event. The outcome of the event was reported as unknown. The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report.