Age: 55.0
Sex: F
Vaccine: VARZOS
Symptoms: Back pain, Dysstasia, Fatigue, Headache, Hyperaesthesia
Clinical narrative: exhaustion; pain in legs; pain in legs, back; pain in legs, back, and back of neck; wave of malaise / feels like she was run over by a truck; nausea; skin is sensitive to the touch described as pain when husband caressed her and pain when water from shower touches skin.; feels like she has the flu but does not; headache in front of head; overall body pain; Sick; difficulty standing up in shower; feels hypersensitive; pain and suggests it may be nerve pain; This case was reported by a consumer via call center representative and described the occurrence of exhaustion in a 55-year-old female patient who received Herpes zoster (Shingrix) for prophylaxis.   Previously administered products included Shingrix with an associated reaction of pain in extremity, Shingrix with an associated reaction of somnolence and Shingrix with an associated reaction of fatigue (1st dose received on unknown date, refer case US2020AMR224531).   On 8th November 2020, the patient received the 2nd dose of Shingrix (intramuscular). On 8th November 2020, less than a day after receiving Shingrix, the patient experienced exhaustion, leg pain, back pain, neck pain and malaise. In November 2020, the patient experienced nausea, touch sensitivity increased, influenza like illness, headache, general body pain, sickness, difficulty in standing, hypersensitivity and nerve pain. Rechallenge with Shingrix was positive. On an unknown date, the outcome of the exhaustion, leg pain, back pain, neck pain, malaise, nausea, touch sensitivity increased, influenza like illness, headache, general body pain, sickness, difficulty in standing and hypersensitivity were not recovered/not resolved and the outcome of the nerve pain was unknown.   It was unknown if the reporter considered the exhaustion, leg pain, back pain, neck pain, malaise, nausea, touch sensitivity increased, influenza like illness, headache, general body pain, sickness, difficulty in standing, hypersensitivity and nerve pain to be related to Shingrix.  Additional details were provided as follows: The patient received the 2nd dose of Shingrix in left deltoid and once home was fine. The patient reported after laying down for a few minutes and all of a sudden she experienced a wave of malaise, exhaustion, and pain in legs, back and back of neck. The patient reported that her skin was sensitive to the touch described as pain when husband caressed her and pain when water from shower touches skin. The patient reported difficulty in describing pain and suggested it may be nerve pain. The patient also complained of headache in front of head, nausea and overall body pain resulting in difficulty standing up in shower. The patient felt like she had the flu but did not, felt like she was run over by a truck, felt hypersensitive, and imagined this must be what shingles felt like.  The patient was not having a rash. The patient suggested she might go to emergency room due to not having a primary care physician at the time of reporting. The reporter did not consent to follow up.; Sender's Comments:  US-GLAXOSMITHKLINE-US2020AMR224531:1st dose, same patient