Age: 67.0
Sex: F
Vaccine: COVID19
Symptoms: Alanine aminotransferase, Alanine aminotransferase increased, Blood cholesterol, Hepatitis, Laboratory test
Clinical narrative: elevated ALT; This spontaneous case was reported by a patient and describes the occurrence of ALANINE AMINOTRANSFERASE INCREASED (elevated ALT) in a 67-year-old female patient who received mRNA-1273.712 (SPIKEVAX 2024-2025 PFS) for COVID-19 prophylaxis.     The patient's past medical history included COVID-19 in September 2023, Weight loss (lost 10 pounds in the last 3 months.) in June 2024, Accident (it was discovered by accident 30 years ago that patient started having elevated ALT) in 1994, ALT high and Abstains from alcohol (Quit drinking - for 3 months, hasn't had any alcohol). Previously administered products included for COVID-19 prophylaxis: moderna (dose 3), moderna (dose 2) and moderna (dose 1). Past adverse reactions to the above products included COVID-19 with moderna and moderna; and No adverse effect with moderna.    On 28-Aug-2024, the patient received fourth dose of mRNA-1273.712 (SPIKEVAX 2024-2025 PFS) (unknown route) 1 dosage form. On 17-Sep-2024,  after starting mRNA-1273.712 (SPIKEVAX 2024-2025 PFS), the patient experienced ALANINE AMINOTRANSFERASE INCREASED (elevated ALT). At the time of the report, ALANINE AMINOTRANSFERASE INCREASED (elevated ALT) had not resolved.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): In 1999, Alanine aminotransferase: 147. In June 2024, Alanine aminotransferase: 77. On 17-Sep-2024, Alanine aminotransferase: 132. On an unknown date, Alanine aminotransferase: normal, sometimes upper normal. and sometimes 50.. On an unknown date, Blood cholesterol: coming down. On an unknown date, Hepatitis: Negative. On an unknown date, Laboratory test: (Negative) Had had all of the genetic tests available at that time having to do with liver disease and everything was negative/Was tested for the typical things that can be genetic - all negative.. On an unknown date, Ultrasound scan: normal/Does not had a diagnosis of fatty liver disease..         Patient did not receive other vaccines in the 4 weeks prior to COVID-19 vaccine. No concomitant medications were provided. Suspect vaccine dosage text was reported as unknown. Patient was a retired nurse who developed elevated ALT after getting recent COVID vaccine. Patient doesn't normally run that high of an ALT. The patient had Moderna COVID vaccines at least 4 times. Hadn't got it last fall 2023, because patient had COVID in September 2023. Doesn't had a diagnosis for liver disease - it was discovered by accident 30 years ago that patient started having elevated ALT. Every year ALT was tested with annual exam. Does not had a diagnosis of fatty liver disease. Cholesterol was lowering down but ALT went up. Patient quitted drinking - for 3 months, had no alcohol. Seemed to have a good effect on cholesterol but not on the liver. Highest ALT ever had was in 1999, 2 months after having a baby. This ALT level was not her usual pattern. Patient had no side effects otherwise. Patient did not have the vaccine since she'd had the disease last September. Reporter causality was not reported. Treatment information was not provided.   This case was linked to US-MODERNATX, INC.-MOD-2022-655102 (E2B Linked Report). This case was linked to MOD-2024-774165 (Patient Link).; Sender's Comments:  US-MODERNATX, INC.-MOD-2022-655102:husband case