Age: 52.0
Sex: F
Vaccine: VARZOS, VARZOS
Symptoms: Cerebrospinal fluid leakage, Guillain-Barre syndrome, Immunoglobulin therapy, Impaired work ability, Infectious mononucleosis
Clinical narrative: GBS, life turned upside down, hospitalized; Got home in really bad shape due to leaking of CSF; Brain was inflamed; Got mononucleosis; Had ulcers in mouth and private area; Had ulcers in mouth and private area; Still can't function, can barely live life; Unable to work; This case was reported by a other health professional and described the occurrence of guillain barre syndrome in a 52-year-old female patient who received Herpes zoster (Shingrix) (batch number KK3JM, expiry date unknown) for prophylaxis.   Concurrent medical conditions included systemic lupus erythematosus.   On 14th October 2022, the patient received the 1st dose of Shingrix (intramuscular). On an unknown date, 3 weeks after receiving Shingrix, the patient experienced guillain barre syndrome (serious criteria hospitalization and GSK medically significant), leakage of cerebrospinal fluid (serious criteria GSK medically significant), brain inflammation (serious criteria GSK medically significant), mononucleosis, mouth ulcer, ulcer, activities of daily living impaired and inability to work. The patient was treated with immunoglobulins nos (Ivig). On an unknown date, the outcome of the guillain barre syndrome was unknown and the outcome of the leakage of cerebrospinal fluid, brain inflammation, mononucleosis, mouth ulcer, ulcer, activities of daily living impaired and inability to work were not recovered/not resolved.   The reporter considered the guillain barre syndrome, leakage of cerebrospinal fluid, brain inflammation, mononucleosis, mouth ulcer, ulcer, activities of daily living impaired and inability to work to be related to Shingrix.     Additional Information: GSK Receipt Date: 10-DEC-2022 and 12-DEC-2022 Reporter's Comment: The reporter had reported that she had received the Shingrix vaccine at the right deltoid region. She had lost work time and pay due to the Shingrix vaccine. She was a full-time university student, and worker also. This vaccine was not part of the vaccine injury program. Her symptoms had persisted and she was diagnosed with Guillain Barre Syndrome, a little over three weeks after vaccine administration.  Her life had turned upside down, it does not matter to her, if she was the 1 in 100,000 this was her life, and the only body she could work with.  She stated that, it was recommended to get this shot because she was over age 50. She was advised not to get the second Shingrix shot. On 8 November 2022, she had went to the emergency room. She was admitted to the hospital. She was hospitalized and had received IVIG treatments. She said that the IVIG had helped a little. When she got home from the hospital, she was in really bad shape due to leaking of (Cerebra Spinal Fluid (CSF).  She stated that her brain was inflamed. She also stated that she had mononucleosis. She said she had ulcers all in her mouth and in her private area. She stated that, she still could not function. She was a contract worker and a student and could not do her jobs. She stated that, she could barely live her life and wondered how she was going to pay her bills. The reporter had consented to follow-up. Additional supportive information: Less than 2 months, after receiving Shingrix, the patient experienced leakage of cerebrospinal fluid, brain inflammation, mononucleosis, mouth ulcer, ulcer, activities of daily living impaired and inability to work.