Age: 75.0
Sex: M
Vaccine: COVID19
Symptoms: Angina pectoris, Arterial occlusive disease, Chest pain, Vasoconstriction
Clinical narrative: Angina; Blocked artery; Vasoconstriction in heart vessels; Chest pain; This spontaneous case was reported by a patient family member or friend and describes the occurrence of ANGINA PECTORIS (Angina) in a 75-year-old male patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.     The patient's past medical history included Stent placement in 2020. Concurrent medical conditions included Hypercholesterolemia. Concomitant products included VITAMINS NOS for an unknown indication.   On 02-Mar-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 31-Mar-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. In April 2021, the patient experienced CHEST PAIN (Chest pain). On an unknown date, the patient experienced ANGINA PECTORIS (Angina) (seriousness criterion medically significant), ARTERIAL OCCLUSIVE DISEASE (Blocked artery) and VASOCONSTRICTION (Vasoconstriction in heart vessels). At the time of the report, ANGINA PECTORIS (Angina), ARTERIAL OCCLUSIVE DISEASE (Blocked artery), CHEST PAIN (Chest pain) and VASOCONSTRICTION (Vasoconstriction in heart vessels) outcome was unknown.            Patient's concomitant medications are cholesterol medications, statins, proton pump inhibitors. Treatment for the event included beta blockers and nitrates. Laboratory investigations performed on an unknown date included stress test whose result was not provided. On 31March2021 he received the second dose, and a few days after the vaccine he started having chest pain, had it for a while, didn't consult right away, and he finally went to the Emergency room on 8April2021 or 10April2021.  Company comment- Based on the current available information and temporal association between the use of the product mRNA-1273 and the start date of the serious unexpected events of Angina pectoris and Arteria occlusive disease, a causal relationship cannot be completely excluded; however case causality is confounded by the increased risk of cardiovascular complications due to the patient's history of stent placement and hypercholesterolemia complicated by the advanced age. Non-serious events of Chest pain and Vasoconstrictions are possible manifestations of Angina pectoris and Arteria occlusive disease,   Reporter did not allow further contact; Sender's Comments: Based on the current available information and temporal association between the use of the product mRNA-1273 and the start date of the serious unexpected events of Angina pectoris and Arteria occlusive disease, a causal relationship cannot be completely excluded; however case causality is confounded by the increased risk of cardiovascular complications due to the patient's history of stent placement and hypercholesterolemia complicated by the advanced age. Non-serious events of Chest pain and Vasoconstrictions are possible manifestations of Angina pectoris and Arteria occlusive disease,