Age: 63.0
Sex: F
Vaccine: COVID19, UNK
Symptoms: Chills, Pyrexia, Rheumatoid arthritis
Clinical narrative: Rheumatoid arthritis flare up; Fever; Chills; This spontaneous case was reported by a consumer and describes the occurrence of RHEUMATOID ARTHRITIS (Rheumatoid arthritis flare up) in a 63-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.    Co-suspect product included non-company product UPADACITINIB (RINVOQ) for Rheumatoid arthritis.    Concurrent medical conditions included Rheumatoid arthritis.   In 2021, the patient received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. In 2021, received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. On 22-Dec-2021, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. On an unknown date, the patient started UPADACITINIB (RINVOQ) (Oral) at an unspecified dose. In 2021, the patient experienced PYREXIA (Fever) and CHILLS (Chills). On an unknown date, the patient experienced RHEUMATOID ARTHRITIS (Rheumatoid arthritis flare up) (seriousness criterion medically significant). At the time of the report, RHEUMATOID ARTHRITIS (Rheumatoid arthritis flare up), PYREXIA (Fever) and CHILLS (Chills) outcome was unknown.            Relevant concomitant medication was not reported.  On an unknown date of 2021, patient received first and second dose of Moderna COVID-19 vaccine and on 22-Dec-2021, patient received booster dose of Moderna COVID-19 vaccine.  On an unknown date, the patient experienced rheumatoid arthritis flare. On an unknown date of 2021, she had Moderna COVID-19 vaccine and experienced fever and chills.  Treatment information was not provided.  It was unknown if patient was enrolled in a COVID-19 vaccine Trial.  The reporter causality for the event of triggered rheumatoid arthritis flare, fever and chills with RINVOQ was not provided.  CC: This spontaneous case concerns a 63year old female patient, with a relevant history of rheumatoid arthritis, who experienced the unexpected, serious (medically significant) adverse event of special interest Rheumatoid arthritis flare up, which occurred unknown days after the third dose of mRNA-1273 vaccine administration. The outcome was reported as unknown. No diagnostic results or treatment information were not provided. Underlying  history of rheumatoid arthritis could be a confounder for the event. The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report.; Sender's Comments: This spontaneous case concerns a 63year old female patient, with a relevant history of rheumatoid arthritis, who experienced the unexpected, serious (medically significant) adverse event of special interest Rheumatoid arthritis flare up, which occurred unknown days after the third dose of mRNA-1273 vaccine administration. The outcome was reported as unknown. No diagnostic results or treatment information were not provided. Underlying  history of rheumatoid arthritis could be a confounder for the event. The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report.