Sex: F
Vaccine: VARZOS
Symptoms: Burning sensation, Condition aggravated, Herpes zoster, Impaired quality of life, Nerve compression
Clinical narrative: since being vaccinated my outbreaks have been back-to-back/suspected vaccination failure; outbreaks have been back-to-back, occur on my butt; I currently have several lesions; clothing is unbearable due to the oozing, Making my life come to a near stop.; experiencing burning in parts of my body; experiencing itching in parts of my body; pinched nerve sensation in my left hip joint that radiates on right side; zapping me awake at night; Making my life come to a near stop; This case was reported by a consumer and described the occurrence of suspected vaccination failure in a 54-year-old female patient who received Herpes zoster (Shingrix) for prophylaxis.   The patient's past medical history included shingles (experienced shingles outbreaks since her early 20's), burning sensation, pruritus, pinched nerve (in left side of body), migraine (antivirals trigger migraines) and sleep disturbance.   In December 2021, the patient received Shingrix. On an unknown date, less than 4 months after receiving Shingrix, the patient experienced vaccination failure (serious criteria GSK medically significant), shingles, skin lesion, skin oozing, burning sensation, pruritus, pinched nerve, sleep disturbance and impaired quality of life. On an unknown date, the outcome of the vaccination failure, shingles, skin oozing, burning sensation, pruritus, pinched nerve, sleep disturbance and impaired quality of life were unknown and the outcome of the skin lesion was recovering/resolving.   It was unknown if the reporter considered the vaccination failure, shingles, skin lesion, skin oozing, burning sensation, pruritus, pinched nerve, sleep disturbance and impaired quality of life to be related to Shingrix.  Additional details were provided as follows: The case was reported by the patient. The age at vaccination was unknown. The patient had experienced shingles outbreaks since her early 20's.  The patient was vaccinated with Shingrix as of December 2021. Before being vaccinated, she would go two to three years without an outbreak. However, since being vaccinated for only two months, her outbreaks have been back-to-back.  The patient currently had several lesions in various stages of healing. The patient had attached a few photos herewith. Here outbreaks occur on the left cheek of her butt. Even clothing was unbearable at times due to the oozing, etc. Making her life come to a near stop.  The patient was unable to take antivirals because they trigger migraines. The patient had also noticed that she was experiencing the same burning and itching in other parts of her body.  Until being vaccinated, she only experienced those sensations, along with the pinched nerve sensation in her left hip joint, which radiated down the left side of her body (zapping her awake at night), had now started happening on her right side.  This always occurred just before a lesion appears. It lasts for two or three days, at times a week, before an outbreak. When her physician authorized her vaccine, even with the knowledge that she already experienced shingles outbreaks, she was perfectly comfortable, if not excited, to finally had this available to her .  The patient was very curious to know if that was a common issue, under the same circumstances. This case was considered as suspected vaccination failure as details regarding completion of primary vaccination schedule and laboratory test confirming shingles were unknown at the time of reporting.