Age: 61.0
Sex: F
Vaccine: VARZOS
Symptoms: Injected limb mobility decreased, Injection site pain, Joint stiffness, Muscular weakness, Musculoskeletal discomfort
Clinical narrative: soreness/adverse reactions occurred on her shoulder; soreness/ adverse reactions occurred on her neck/dull ache in neck area; decreased range of motion in arm of injection; weakness extended; numbness in left side of body/ in shoulder/neck numbness; discomfort; Shoulder weakness/ neck weakness; Shoulder Discomfort/ Neck discomfort; Elbow pain; Elbow stiffness; Elbow weakness/ Elbow discomfort; soreness/sore arm/ sore arm on upper area of arm/dull ach in upper arm of injection site; dull ache in deltoid and upper arm of injection site; stiffness/ stiffness occurred on her upper arm, shoulder, neck and elbow; This case was reported by a pharmacist via call center representative and described the occurrence of injection site pain in a 61-year-old female patient who received Herpes zoster (Shingrix) (batch number KB99G, expiry date 15th November 2021) for prophylaxis.   On 29th November 2018, the patient received the 1st dose of Shingrix (intramuscular) .5 ml. On 29th November 2018, immediately after receiving Shingrix, the patient experienced injection site pain, localized muscle pain and limbs stiffness. On an unknown date, the patient experienced shoulder pain, neck pain, injected limb mobility decreased, weakness, body numbness, discomfort, muscle weakness, musculoskeletal discomfort, arthralgia, stiff joint and arthropathy. The patient was treated with non-drug therapy (Physical Therapy (Nos)). On an unknown date, the outcome of the injection site pain, localized muscle pain, limbs stiffness, shoulder pain, neck pain, injected limb mobility decreased, weakness, body numbness, discomfort, muscle weakness, musculoskeletal discomfort, arthralgia, stiff joint and arthropathy were not recovered/not resolved.   It was unknown if the reporter considered the injection site pain, localized muscle pain, limbs stiffness, shoulder pain, neck pain, injected limb mobility decreased, weakness, body numbness, discomfort, muscle weakness, musculoskeletal discomfort, arthralgia, stiff joint and arthropathy to be related to Shingrix.  Additional details were provided as follows: The patient received her 1st dose of Shingrix in her left arm. Within 12 hours following administration, the patient immediately experienced a sore stiff arm at the injection site. The patient had dull ache in deltoid and upper arm of injection site.   She later experienced numbness on the left side of her body which had not dissipated.   The patient also reported extended weakness and discomfort.  These adverse reactions occurred on her upper arm and shoulder and in her neck and elbow on the left side of her body. The patient reported of having decreased range of motion for over 6 months. The patient had an MRI of her neck and shoulder to rule out any injection site error which was negative.   She also had a radial nerve test to verify any nerve damage which was negative as well.   The patient resumed physical therapy. The reporter consented to follow up. The case US2019115933 was found to be duplicate of case US2019115937. Hence case US2019115937 would be deleted and all the information of this case will be added in case US2019115933 which is case of record for this patient.      Lab Comments: on an unknown date, MRI of neck and shoulder and radial nerve test was performed.