Sex: F
Vaccine: UNK, VARZOS
Symptoms: Pruritus genital, Rash, Rash pruritic, Skin discolouration, Urticaria
Clinical narrative: rash that went from her back halfway down to her tailbone / It was itchy; red mark went to her stomach; itchy hives around the belt area; triangular mark on her arm; had been eating a lot of nuts/food allergy; got a triangular mark on her arm and could not lift it up; eyes looked like they had conjunctivitis but they cleared up; had genital itching; This case was reported by a consumer and described the occurrence of mobility decreased in a 62-year-old female patient who received Herpes zoster (Shingrix) for prophylaxis.   Co-suspect products included hydrocortisone for genital itching.   The patient's past medical history included conjunctivitis. Previously administered products included tdap with an associated reaction of headache (number of years ago she had a tdap shot and experienced headache refer case US2021AMR060204). Concurrent medical conditions included pre-diabetes and house dust mite allergy (allergic to dust mites and pet danger).   On 17th July 2020, the patient received the 1st dose of Shingrix. On an unknown date, the patient started hydrocortisone (topical) at an unknown dose and frequency. In September 2020, between 1 and 3 months after receiving Shingrix and an unknown time after starting hydrocortisone and Zyrtec, the patient experienced genital itching. On an unknown date, the patient experienced mobility decreased, conjunctivitis, itchy rash, erythema, hives, skin discoloration and food allergy. The patient was treated with cetirizine hydrochloride (Zyrtec) and famotidine (Pepcid). The action taken with hydrocortisone was unknown. On an unknown date, the outcome of the mobility decreased, conjunctivitis, genital itching, erythema and hives were recovered/resolved and the outcome of the itchy rash was not recovered/not resolved and the outcome of the skin discoloration and food allergy were unknown.   The reporter considered the mobility decreased, conjunctivitis, genital itching and skin discoloration to be related to Shingrix. It was unknown if the reporter considered the itchy rash, erythema, hives and food allergy to be related to Shingrix.   Additional details were provided as follows: Age at vaccination was not reported but it could be 61 or 62 years. The case was reported by the patient for herself. The reporter provided her email address and age but did not want to provide her street address or her date of birth. The patient got Shingrix shot and got a triangular mark on her arm and could not lift it up. The patient did not probe to confirm it was the injected arm however that was the impression she got. Also her eyes looked like she had conjunctivitis but they cleared up. In September 2020 she went to the OB/GYN (Gynecologist) because she had genital itching.  Gynecologist advised to use hydrocortisone topical ointment, she used it for a brief time but it was not working.  The itching went to her shoulders near her bra (brassiere) strap and had a rash that went from her back halfway down to her tailbone. It was itchy and red mark went to her stomach, it was across the stomach and it itched.  The patient thought it was important to mention that it was not just half of her body because she did not think it was a shingles rash because shingles rashes often were on one side of the body only and they may be painful.  The patient said her issue was not just on one half and was not painful. The patient continued to have genital itching and then itchy hives around the belt area.  In November 2020 the patient went back to the doctor (allergist) as the itching had not resolved.  The patient had used a different detergent but that it was a detergent that she had previously used in the past.  But to be cautious she re washed all of those clothes in the original detergent.  The patient had been eating a lot of nuts and asked her doctor if the rash/hives/itching could have been due to a food allergy.  The doctor prescribed Zyrtec, Pepcid, and a different ointment. (She cannot recall the name of the ointment). She was told to use these products for 2 weeks.  After 2 weeks her symptoms had not cleared so she took them for another 2 weeks. For tolerance in 2nd dose refer case US2021AMR060203.; Sender's Comments:  US-GLAXOSMITHKLINE-US2021AMR060203:Same reporter, Shingrix 1st dose US-GLAXOSMITHKLINE-US2021AMR061311:Same reporter