Sex: F
Vaccine: VARZOS
Symptoms: Oral mucosal blistering, Oral mucosal erythema, Oral pain, Sinusitis
Clinical narrative: Redness around mouth; painful mouth; burning mouth syndrome/ Burning mouth; Blisters in mouth; blisters on upper lip; completely exhausting; Shingles/ Shingles on butt; Sinus infection/ something affected mouth nerves; Sinus infection/ something affected mouth nerves; This case was reported by a consumer via call center representative and described the occurrence of shingles in a 75-year-old female patient who received Herpes zoster (Shingrix) for prophylaxis.   The patient's past medical history included shingles.   In January 2019, the patient received the 1st dose of Shingrix. In February 2019, 28 days after receiving Shingrix, the patient experienced sinus infection and oral discomfort. On an unknown date, the patient experienced shingles, oral redness, oral pain, burning mouth syndrome, blistering of mouth, lip blister and exhaustion. The patient was treated with amoxicillin trihydrate, potassium clavulanate (Augmentin Bid), ceftriaxone sodium (Rocephin), acyclovir and medication unknown (Nerve Medication). On an unknown date, the outcome of the shingles was not recovered/not resolved and the outcome of the sinus infection and oral discomfort were recovered/resolved and the outcome of the oral redness, oral pain, burning mouth syndrome, blistering of mouth, lip blister and exhaustion were unknown.   It was unknown if the reporter considered the shingles, sinus infection, oral discomfort, oral redness, oral pain, burning mouth syndrome, blistering of mouth, lip blister and exhaustion to be related to Shingrix.  Additional details were provided as follows: The age at vaccination was not reported but it could be 74 years or 75 years. Sometime in January 2019, the patient got the 1st injection. The exact date or information regarding the vaccine was unknown. 6 weeks after the 1st dose, the patient experienced first episode of shingles. She took Acyclovir and it dried up within about three days. The patient again had shingles and it was on her butt.  The patient stated, she had shingles before but never like this. But since from receiving Shingrix, the patient had shingles and something affecting the nerves around her mouth. In February 2019, the patient had a sinus infection and it was really bad. The patient needed two Rocephin shots and took Augmentin twice. About the 4th or 5th week following the dose of Shingrix, the patient had redness around her mouth and was extremely painful. Her mouth burned. She thought, what around her mouth was shingles. The patient also went to the dermatologist because of the redness around her mouth and was told it was something with her nerve and she had burning mouth syndrome. The patient also developed blisters in her mouth and upper lip.  She never had fever blisters in her life. It was extreme but they were recovering because she was taking Nerve Renew, which had alphaliphic acid antioxidant support. The patient would felt like it was healing one day but she supposed that due to her mood, she would get a new blister. Since from the past 6 months, the patient had been completely exhausting.