Age: 67.0
Sex: M
Vaccine: VARZOS
Symptoms: Asthma, Erythema, Fatigue, Hyperhidrosis, Hypertension
Clinical narrative: his leg started to itch; a big rash the size of a hand,; "raised bumps/raised area; exhaustion; asthma got worse; soaked in sweat; itching and it was completely red; high blood preasure; This case was reported by a consumer via call center representative and described the occurrence of blood pressure high in a 67-year-old male patient who received Herpes zoster (Shingrix) for prophylaxis.   Co-suspect products included mepolizumab (Nucala) powder for solution for injection for an unknown indication and cefuroxime unknown for an unknown indication.   Concurrent medical conditions included asthma. Concomitant products included prednisone.   On 1st April 2019, the patient received Shingrix and Nucala at an unknown dose and frequency. On an unknown date, the patient started cefuroxime at an unknown dose and frequency. On 1st April 2019, less than a day after receiving Shingrix, immediately after starting Nucala and not applicable after starting cefuroxime, the patient experienced blood pressure high. On an unknown date, the patient experienced itchy legs, rash, papular rash, exhaustion, asthma aggravated, hyperhidrosis and erythema. On an unknown date, the outcome of the blood pressure high, exhaustion, hyperhidrosis and erythema were unknown and the outcome of the itchy legs, rash and papular rash were recovering/resolving and the outcome of the asthma aggravated was not recovered/not resolved.   It was unknown if the reporter considered the blood pressure high, itchy legs, rash, papular rash, exhaustion, asthma aggravated, hyperhidrosis and erythema to be related to Shingrix and Nucala. It was unknown if the reporter considered the itchy legs, rash and papular rash to be related to cefuroxime.  Additional details were provided as follows: The age at vaccination was not reported. The patient reported that he had CBID (patient did not define acronym), and chronic asthma.  The patient reports that he has been taking Prednisone, and Cefuroxime off and on for five years. The patient was prescribed the medication Nucala subcutaneous injection once monthly. On 1st April 2019, the patient received Shingrix vaccination while taking Nucala. He reported immediate high blood pressure after the Nucala injection, but it passed. He also reported that about two weeks after Nucala he was sitting at the piano and all of a sudden, his leg started to itch. He looked down and soaked in sweat. he looked at leg where it was itching and it was completely red, a big rash the size of a hand, and a raised area. The patient reports that a rash, raised bumps, was developing on his arms as well. He also reported exhaustion directly after the Nucala injection. He reported that the rashes had not resolved, he stated the rash started at a 10, it was 2.5 now. It was getting better. The patient reported that he had been taking Prednisone, and Cefuroxime off and on for five years. He reported his doctor discontinued his Cefuroxime due to his current reactions. As a result of discontinuance, the patient stated the rash was half gone. The patient reported that stopping the Cefuroxime had resulted in his rash getting better. The patient stated, as got older by asthma got worse