Sex: M
Vaccine: COVID19
Symptoms: Body temperature, COVID-19, Crohn's disease, Diaphragmatic disorder, Lung disorder
Clinical narrative: Two Flare ups of Crohns disease; DIAPHRAGM DIED AND THAT ONLY HAD HALF OF A LUNG; RHEUMATOID ARTHRITIS WORSENED; COVID-19; DIAPHRAGM DIED AND THAT ONLY HAD HALF OF A LUNG; This spontaneous case was reported by a consumer and describes the occurrence of CROHN'S DISEASE (Two Flare ups of Crohns disease), DIAPHRAGMATIC DISORDER (DIAPHRAGM DIED AND THAT ONLY HAD HALF OF A LUNG) and RHEUMATOID ARTHRITIS (RHEUMATOID ARTHRITIS WORSENED) in an elderly male patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.    Co-suspect product included non-company product UPADACITINIB (RINVOQ) for Rheumatoid arthritis.    Concurrent medical conditions included Crohn's disease and Rheumatoid arthritis.   On an unknown date, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form On an unknown date, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form and third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. and UPADACITINIB (RINVOQ) (Oral) at an unspecified dose. On an unknown date, the patient experienced CROHN'S DISEASE (Two Flare ups of Crohns disease) (seriousness criteria hospitalization and medically significant), DIAPHRAGMATIC DISORDER (DIAPHRAGM DIED AND THAT ONLY HAD HALF OF A LUNG) (seriousness criteria hospitalization and medically significant), RHEUMATOID ARTHRITIS (RHEUMATOID ARTHRITIS WORSENED) (seriousness criterion medically significant), COVID-19 (COVID-19) and LUNG DISORDER (DIAPHRAGM DIED AND THAT ONLY HAD HALF OF A LUNG). At the time of the report, CROHN'S DISEASE (Two Flare ups of Crohns disease), DIAPHRAGMATIC DISORDER (DIAPHRAGM DIED AND THAT ONLY HAD HALF OF A LUNG) and LUNG DISORDER (DIAPHRAGM DIED AND THAT ONLY HAD HALF OF A LUNG) outcome was unknown and RHEUMATOID ARTHRITIS (RHEUMATOID ARTHRITIS WORSENED) and COVID-19 (COVID-19) had resolved.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On an unknown date, Body temperature: 103 to 104 fahrenheit 103 to 104 Fahrenheit.         No concomitant medication information was reported. Patient reported that he was diagnosed with COVID. He had a really bad cough, had a fever of 103 to 104 Fahrenheit, chills and was sneezing. Bad cough, fever, chills, sneezing were subsumed under COVID. Also, the patient had sweating, lost his voice for one week, and  he had a reaction to his second Moderna vaccine. He did not see any change in his rheumatoid arthritis while on Rinvoq for two years. He had no benefit and that his rheumatoid arthritis got worse . He had two flare ups of crohn's disease that put him in the hospital both times. It was unknown if patient was enrolled in a COVID-19 Vaccine Trial. No treatment medication was reported.  Company Comment: This is a Spontaneous case concerning a 71-year-old male patient, with relevant medical conditions of Chron´s disease and Rheumatoid arthritis, who experienced the unexpected and serious (due to hospitalization and medically significant) events of Chron´s disease and Diaphragmatic disorder, the unexpected and serious (due to medically significant) AESI of Rheumatoid arthritis, and the unexpected and non-serious AESI of COVID-19,  which occurred on an unknown date after a dose of mRNA-1273 vaccine. Patient reported he experienced two flare ups of Crohn´s disease, his diaphragm died and only had half of a lung. He was also diagnosed with COVID-19. He had a really bad cough, pyrexia, sweating, lost his voice for one week and was sneezing. He also reported he did not see any change in his rheumatoid arthritis and it got worse while on treatment with Upadacitinib (Rinvoq) for 2 years, non-company product that remains co-suspect. No information disclosed about diagnostic tests performed or treatment received. Underlying Chron´s disease and rheumatoid arthritis can present relapses as part of the natural history of disease, so that confounds the case. The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report.; Sender's Comments: This is a Spontaneous case concerning a 71-year-old male patient, with relevant medical conditions of Chron´s disease and Rheumatoid arthritis, who experienced the unexpected and serious (due to hospitalization and medically significant) events of Chron´s disease and Diaphragmatic disorder, the unexpected and serious (due to medically significant) AESI of Rheumatoid arthritis, and the unexpected and non-serious AESI of COVID-19,  which occurred on an unknown date after a dose of mRNA-1273 vaccine. Patient reported he experienced two flare ups of Crohn´s disease, his diaphragm died and only had half of a lung. He was also diagnosed with COVID-19. He had a really bad cough, pyrexia, sweating, lost his voice for one week and was sneezing. He also reported he did not see any change in his rheumatoid arthritis and it got worse while on treatment with Upadacitinib (Rinvoq) for 2 years, non-company product that remains co-suspect. No information disclosed about diagnostic tests performed or treatment received. Underlying Chron´s disease and rheumatoid arthritis can present relapses as part of the natural history of disease, so that confounds the case. The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report.