Sex: F
Vaccine: COVID19, COVID19, COVID19, COVID19
Symptoms: Headache, Influenza, Metabolic function test, Pyrexia, Renal pain
Clinical narrative: flare up of her guillain-barre; flare up of her guillain-barre; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP) from medical information team. The reporter is the patient.  A 54-year-old female patient received BNT162b2 (BNT162B2), as dose 3 (booster), single (Batch/Lot number: unknown) for covid-19 immunisation. The patient's relevant medical history included: "Myasthenia Gravis" (ongoing), notes: Comments: Myasthenia Gravis, Also reports hx of Myasthenia Gravis; "Hashimoto's disease" (unspecified if ongoing), notes: Comments: Hashimoto's disease; "Guillain Barre syndrome" (ongoing), notes: Comments: Guillain Barre syndrome; "COVID", start date: Mar2020 (unspecified if ongoing), notes: Had first symptoms of Covid Mar2020.; "over weight" (unspecified if ongoing). Concomitant medication(s) included: METHYLPREDNISOLONE taken for guillain-barre syndrome, myasthenia gravis (ongoing). Vaccination history included: Bnt162b2 (First Dose: Apr2021, she thinks, when they came out), administration date: Apr2021, when the patient was 52 years old, for COVID-19 Immunization, reaction(s): "Has autonomic dysfunction and had an increase of that as well", "balance was off", "Her eyes, she had the miller fisher variant and her eyes got really wonky again", "flareup of her guillain-barre", "after the first vaccine, her reflexes went away and that was it"; Bnt162b2 (Dose 2), for COVID-19 Immunization, reaction(s): "flare up of her guillain-barre". The following information was reported: GUILLAIN-BARRE SYNDROME (medically significant), CONDITION AGGRAVATED (medically significant), outcome "recovered" and all described as "flare up of her guillain-barre". The event "flare up of her guillain-barre" required physician office visit. The patient underwent the following laboratory tests and procedures: Full blood count: that came back good, everything was good; Metabolic function test: that came back good, everything was good. Therapeutic measures were taken as a result of guillain-barre syndrome, condition aggravated. Clinical course: Patient had first symptoms of Covid Mar2020. Was having a Myasthenia flare up and also getting Guillain-Barre symptoms with it. Then, was on a low dose, 2mg for and with the Covid, they bumped it up to 4mg and has stayed at 4mg since then. Now, because of what is going on, they will bump it up for just a week to 10mg. Will start the 10mg dose today. Just talked to doctor about it. Had physician appointment after the first time, for sure. went again this May2022 and was symptomatic then, as well. Then, had surgery in Jun2022 and had more symptoms then. Hard to know which caused the symptoms. Got a flareup of Guillain-Barre and hadn't had a flareup for 30 years. They did an IVIG, intravenous immunoglobulin treatment. She just finished the series last week. Clarified this treatment as the Gamma Gard infusion which was previously mentioned that she believes she had a reaction to.   The information on the batch/lot number for BNT162b2 has been requested and will be submitted if and when received.