Age: 0.35
Sex: F
Vaccine: DTPHIB
Symptoms: Lethargy, Lumbar puncture, Mental retardation severity unspecified, Metabolic function test, Muscle spasms
Clinical narrative: pt recv vax 20JAN97 & leg swollen twice size & cried for 5hr;pt would not sleep & pulled legs to stomach;crying spell;on 3FEB97 jerking, to ER;6FEB99 to hosp Dx sz;pt cannot talk or feed herself, has balance problems,gets infections easily  Annual follow-up received on 9/22/00 states that the pt continues to have over 100 seizures per day. She does not talk and understands very little. All medication has failed. Follow-up information received 12-JUL-2002 identified and further described the patient's adverse events. Followiing clarification of the source documents, the primary suspect vaccine was changed from Tri-Immunol to Tetramune. A mother reported that her 4-month-old daughter who had developed a respiratory syncytial viral infection (following immunization with "RSV" (manufacturer unknown vaccine) and was treated with an unspecified medication at the end of December 1996, received her second doses of Tatramune and IPV vaccines on 20-JAN-1997. According to the patient's grandmother, the patient was seen by the physician for persistent RSV symptoms that day. The patient was afebrile and immunization were administered. Shortly therafter, the patient was taken to her grandmother's home where she reportedly experienced inconsolable, high-pitched screamint. Her legs had "doubled in size" and she pulled her legs up, as if in pain. Her crying resolved 5 hours later, she slept. Following these events, the patient had sleep disturbances and her sleeping pattern was "horrible". The patient now cried inconsolably for long periods of time and her eyes seemed "totally different, like someone scared." She was lethargic and id not "respond as before." Her mother reported that she did not recognize anyone; her personality slight jerking movements. A physician's appointment was made. That night, her jerking and crying worsened and she was taken to the emergency room. A diagnosis of colic was made. The physician's appointment was canceled; however, a short time later, the patient was requested to be seen in the office as soon as possible. Unspecified blood work was performed and the patient was admitted to the hosptial on 03-FEB-1997. An EEG was performed and a diagnosis of infantile spasms was made. The patient was treated with adrenocortiotropic hormone following her recovery from RSV. Numerous procedures and tests were performed including an MRI scan, "Spec" scan, lumbar puncture, CAT scan and metabolic and genetic testing. Results were not provided. According to the patient's grandmother, "nothing shows up". She was prescribed a ketogenic diet and has had a vague nerve stimulator inserted. She has been treted with unspecified medications. As of 24-APR-2001, the patient can walk and sit up. She cannot talk, and cognitively, she is 6 months of age. The patient is incontinent and cannot feed herself with a spoon. The patient has 20 to 100 seizures per day. The grandmother indicated that the treating physician did not think the patient would progress any further than she has. The patient's "eyes and brain do not work correctly." Her daughter was "braindamaged." This report was directly submitted to VAERS by the reporter. A copy of this report has been forwarded to Aventis Pasteur, manufacturer of IPV. See NCN: HQ0118425APR2001.