Age: 71.0
Sex: F
Vaccine: UNK, VARZOS
Symptoms: Depression, Extensive swelling of vaccinated limb, Joint swelling, Nasal congestion, Nasal discomfort
Clinical narrative: Swelling in hands; Depressed; breaking out (rash) / 4-5 marks around left side of waist; joint swelling in hands and knuckles; Nasal Congestion; Runny Nose; Nose described as feeling thick and swollen; Nose swollen; This case was reported by a consumer via call center representative and described the occurrence of extensive swelling of vaccinated limb in a 71-year-old female patient who received Herpes zoster (Shingrix) for prophylaxis.   Co-suspect products included zoledronic acid (Reclast) for an unknown indication.   The patient's past medical history included malignant neoplasm of abdomen (Cancer survivor tumor in abdomen at age 57). Concomitant products included vitamin d and Herpes zoster (Shingrix).   On 17th February 2020, the patient received the 2nd dose of Shingrix (intramuscular) 50 µg. On 5th October 2019, the patient started Reclast at an unknown dose and frequency. In May 2020, less than 3 months after receiving Shingrix, the patient experienced extensive swelling of vaccinated limb, depression, rash, swollen joints, nasal congestion, runny nose, nasal discomfort and nasal edema. The patient was treated with benadryl (nos) (Benadryl). The action taken with Reclast was unknown. On an unknown date, the outcome of the extensive swelling of vaccinated limb, nasal discomfort and nasal edema were unknown and the outcome of the depression and rash were recovering/resolving and the outcome of the swollen joints, nasal congestion and runny nose were not recovered/not resolved.   It was unknown if the reporter considered the extensive swelling of vaccinated limb, depression, rash, swollen joints, nasal congestion, runny nose, nasal discomfort and nasal edema to be related to Shingrix.  Additional details were provided as follows: In November 2019, the patient received 1st dose. The patient received 2nd dose in left arm. Around the first week in May consumer reports developing a runny nose with nasal congestion, joint swelling in hands and knuckles, breaking out (rash) in 4-5 areas around left side of waist, and feeling depressed. Nose described as feeling thick and swollen, Nose swollen and consumer reported about taking Benadryl which to help throughout the day but still bothersome.  Swelling in hands were to point where she was unable to remove ring from finger.  The consumer reported that the swelling might be due to Reclast bone IV infusion, which her infusion, or 5 out of 5, was administered on 5th October 2019.  The reporter stated that broke with 4 to 5 marks around left side of waist area around the same time her husband a small bout of shingles with no prior history of any shingles vaccine. Lastly, the consumer reported that feeling depressed due to the events listed and also being a cancer survivor where a tumor was found on her abdomen when she had just turned 57. Caller does not want to go through fighting cancer again or any more disease states.  She reported only prescription taken was Vitamin D. The reporter did consent to follow up. This case has been linked with case US2020AMR096108, reported by the same reporter; Sender's Comments:  US-GLAXOSMITHKLINE-US2020AMR096108:Same reporter