Age: 43.0
Sex: F
Vaccine: COVID19, UNK
Symptoms: Joint swelling, Loss of personal independence in daily activities, Myalgia, Pain, Pyrexia
Clinical narrative: body ache; Fever; Arthralgia, stiffness in more than four joints in knees, hands, feet and knukles; swollen joints in knees, hands and knuckles; Walking difficulty/some problem with usual activity; health score was 70/100/Reduced general condition; Generalized aching/pain/tender; Activities of daily living impaired; Stiffness joints; vocal cord dysfunction; This spontaneous case was reported by a physician and describes the occurrence of VOCAL CORD DYSFUNCTION (vocal cord dysfunction), JOINT SWELLING (swollen joints in knees, hands and knuckles), GAIT DISTURBANCE (Walking difficulty/some problem with usual activity), GENERAL PHYSICAL HEALTH DETERIORATION (health score was 70/100/Reduced general condition) and PAIN (Generalized aching/pain/tender) in a 43-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.    Co-suspect product included non-company product ADALIMUMAB (HUMIRA) for Psoriatic arthritis.    The patient's past medical history included Arthralgia (STIFFNESS IN MORE THAN FOUR JOINTS IN KNEES, HANDS, FEET AND KNUCKLES). Concurrent medical conditions included Allergy, Asthma, Shortness of breath, Sinus infection, Jaw pain and Psoriatic arthritis.   On 09-Mar-2021, the patient started ADALIMUMAB (HUMIRA) (Subcutaneous) 40 mg twice a day. On 23-Apr-2021, the patient received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. In 2021, received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. In March 2021, the patient experienced JOINT SWELLING (swollen joints in knees, hands and knuckles), GAIT DISTURBANCE (Walking difficulty/some problem with usual activity), GENERAL PHYSICAL HEALTH DETERIORATION (health score was 70/100/Reduced general condition), PAIN (Generalized aching/pain/tender), LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (Activities of daily living impaired), JOINT STIFFNESS (Stiffness joints) and ARTHRALGIA (Arthralgia, stiffness in more than four joints in knees, hands, feet and knukles). In April 2021, the patient experienced PYREXIA (Fever). In 2021, the patient experienced VOCAL CORD DYSFUNCTION (vocal cord dysfunction). On an unknown date, the patient experienced MYALGIA (body ache). The patient was treated with IBUPROFEN for Adverse event, at an unspecified dose and frequency and AMOXICILLIN, CLAVULANIC ACID (AUGMENTIN [AMOXICILLIN;CLAVULANIC ACID]) for Adverse event, at an unspecified dose and frequency. At the time of the report, VOCAL CORD DYSFUNCTION (vocal cord dysfunction), PYREXIA (Fever) and MYALGIA (body ache) outcome was unknown and JOINT SWELLING (swollen joints in knees, hands and knuckles), GAIT DISTURBANCE (Walking difficulty/some problem with usual activity), GENERAL PHYSICAL HEALTH DETERIORATION (health score was 70/100/Reduced general condition), PAIN (Generalized aching/pain/tender), LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES (Activities of daily living impaired), JOINT STIFFNESS (Stiffness joints) and ARTHRALGIA (Arthralgia, stiffness in more than four joints in knees, hands, feet and knukles) had not resolved.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): In 2021, Computerised tomogram: normal (normal) normal.     For mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular), the reporter did not provide any causality assessments.   No concomitant medications were provided by the reporter.  Patient reported multiple adverse events after receiving the vaccine. The pain has worsened. In Mar 2021, she got Health Score of 70/100.  Based on the current available information and temporal association between the use of the product and the start date of the events, a causal relationship cannot be excluded.  Concomitant medical conditions/medications could be potentially confounders/co-suspects for the events; Sender's Comments: Based on the current available information and temporal association between the use of the product and the start date of the events, a causal relationship cannot be excluded.  Concomitant medical conditions/medications could be potentially confounders/co-suspects for the events.