Age: 77.0
Sex: M
Vaccine: VARZOS, VARZOS
Symptoms: Emotional distress, Pruritus, Rash, Rash erythematous, Rash macular
Clinical narrative: rash / rash is worsening; Red raised area; Large whelps; blisters; Very itchy; Have the appearance of Shingles; can't sleep at night; Dermal Hypersensitiviy Syndrome; This case was reported by a consumer via call center representative and described the occurrence of rash in a 77-year-old male patient who received Herpes zoster (Shingrix) for prophylaxis.   Previously experienced adverse reactions included rash (mild red pimple rash). Previously administered products included Zostavax (received 3 to 4 years ago).   On 27th January 2020, the patient received the 1st dose of Shingrix. On 31st January 2020, 4 days after receiving Shingrix, the patient experienced rash, erythema, hives, blister, pruritus, shingles, difficulty sleeping and cutaneous hypersensitivity. The patient was treated with emollients and protectives (Cerave), topical steroid nos (Topical Steroid) and prednisone. On an unknown date, the outcome of the rash and pruritus were not recovered/not resolved and the outcome of the erythema, hives, blister, shingles, difficulty sleeping and cutaneous hypersensitivity were unknown.   It was unknown if the reporter considered the rash, erythema, hives, blister, pruritus, shingles, difficulty sleeping and cutaneous hypersensitivity to be related to Shingrix.  Additional details were provided as follows: After receiving Shingrix, the patient experienced a rash that was small red raised area that began on his back moved to his lower back then to chest were and at the time of reporting, large whelps and had spread to his arms, legs and ankles.  The patient states it was very itchy and when he did scratch it flared to blisters that had the appearance of Shingles.  The patient had not been told by his primary or his dermatologist that he had shingles.  The patient noted he could not sleep at night due to the itching and his life had become consumed with trying to find a cure for this as it had been going on for 4 months at the time of reporting.  The patient saw his primary physician on 11th February 2020 for itching. He was given a topical steroid, after 1 week it had not resolved. He then saw his Dermatologist on 21st January 2020 for the rash and itching. He was tried on a regimen of topical steriods, oral prednisone helped but was short lived. He was then given a prednisone injection on 06th May 2020 but noted no results with that. He had found one cream that helped, Cerave, and he noted that helped more in the beginning than it did at the time of reporting.  He believed the rash was worsening.  The patient also noted a biopsy was done by the Dermatologist on 11th March 2020 and shown not to be psoriasis, or eczema, the stitches for the biopsy were removed at the visit done on 25th March 2020. He stated he was told by his primary at the first visit this was dermal hypersensitiviy syndrome. The reporter was consented to follow up.      Lab Comments: Biopsy was done by the Dermatologist on 11th March 2020 and shown not to be psoriasis, or eczema, the stitches for the biopsy were removed at the 25th March 2020 visit.