Age: 81.0
Sex: M
Vaccine: COVID19
Symptoms: Pyrexia
Clinical narrative: feeling poorly and got progressively worse; he currently has a cold; had a fever a couple days ago; myasthenia gravis; Inappropriate schedule of product administration; This spontaneous case was reported by a consumer and describes the occurrence of MYASTHENIA GRAVIS (myasthenia gravis) in an 81-year-old male patient who received mRNA-1273.815 (SPIKEVAX 2023-2024) (batch nos. 3031203 and 3030949) for COVID-19 prophylaxis. The occurrence of additional non-serious events is detailed below.     Question:Describe relevant medical history/conditions, allergy, concomitant diseases and risk factor. Answer: Stenosis in spinal column. Age related arthritis.  The patient's past medical history included COVID-19. Previously administered products included for Product used for unknown indication: Covid-19 vaccine (Dose 1), Covid-19 vaccine (Dose 2), Covid-19 vaccine (Dose 3), Covid-19 vaccine (Dose 7), Covid-19 vaccine (Dose 5), Covid-19 vaccine (Dose 6) and Covid-19 vaccine (Dose 4). Past adverse reactions to the above products included No adverse effect with Covid-19 vaccine, Covid-19 vaccine, Covid-19 vaccine, Covid-19 vaccine, Covid-19 vaccine, Covid-19 vaccine and Covid-19 vaccine. Concurrent medical conditions included Spinal stenosis (Stenosis in spinal column) and Arthritis (Age related arthritis.).   On 08-Nov-2023, the patient received eighth dose of mRNA-1273.815 (SPIKEVAX 2023-2024) (unknown route) 1 dosage form. On 22-Nov-2023, received ninth dose of mRNA-1273.815 (SPIKEVAX 2023-2024) (unknown route) dosage was changed to 1 dosage form. On 22-Nov-2023,  after starting mRNA-1273.815 (SPIKEVAX 2023-2024), the patient experienced INAPPROPRIATE SCHEDULE OF PRODUCT ADMINISTRATION (Inappropriate schedule of product administration). On 04-Nov-2024, the patient experienced MYASTHENIA GRAVIS (myasthenia gravis) (seriousness criterion medically significant). On an unknown date, the patient experienced FEELING ABNORMAL (feeling poorly and got progressively worse), NASOPHARYNGITIS (he currently has a cold) and PYREXIA (had a fever a couple days ago). At the time of the report, MYASTHENIA GRAVIS (myasthenia gravis), FEELING ABNORMAL (feeling poorly and got progressively worse), NASOPHARYNGITIS (he currently has a cold) and PYREXIA (had a fever a couple days ago) had not resolved and INAPPROPRIATE SCHEDULE OF PRODUCT ADMINISTRATION (Inappropriate schedule of product administration) outcome was unknown.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On 01-Oct-2024, Blood test: LRP4 antibodies.         Concomitant product use was not provided by the reporter.  Suspect vaccine dosage text was reported as unknown.  It was reported that a couple weeks after those vaccines, patient started feeling poorly and got progressively worse. Patient figured it was old age however he could hardly walk. The reporter states that patient would wake up feeling ok, but the more he moved, the more pain he experienced. Patient currently had cold and had a fever a couple days ago. Patient asked his neurosurgeon if he could have gotten this diagnosis from the vaccine and the neurosurgeon said that there was a possibility.  Treatment information was not provided.; Reporter's Comments: Patient's advanced age and Stenosis in spinal column remains as confounding factors for Myasthenia gravis. The benefit-risk relationship of the product is not affected by this report.