Sex: U
Vaccine: VARZOS, VARZOS
Symptoms: Blister, Herpes zoster, Post herpetic neuralgia, Rash, Scab
Clinical narrative: Post herpetic neuralgia; Suspected vaccination failure; Diagnosed with shingles/the blister and scabbing finally cleared up /the rash and blistering clears up and goes away; This serious case was reported by a consumer via interactive digital media and described the occurrence of vaccination failure in a patient who received Herpes zoster (Shingrix) for prophylaxis.   Co-suspect products included Herpes zoster (Shingrix) for prophylaxis.   On an unknown date, the patient received the 2nd dose of Shingrix and the 1st dose of Shingrix. On 24-AUG-2024, more than 2 years after receiving Shingrix and Shingrix, the patient experienced vaccination failure (Verbatim: Suspected vaccination failure) (serious criteria GSK medically significant) and shingles (Verbatim: Diagnosed with shingles/the blister and scabbing finally cleared up /the rash and blistering clears up and goes away). On an unknown date, the patient experienced post herpetic neuralgia (Verbatim: Post herpetic neuralgia). The patient was treated with gabapentin, ibuprofen (Advil Liqui Gels) and paracetamol (Tylenol). The outcome of the vaccination failure was not reported and the outcome of the shingles was resolved and the outcome of the post herpetic neuralgia was not resolved.   It was unknown if the reporter considered the vaccination failure, shingles and post herpetic neuralgia to be related to Shingrix and Shingrix.     The company considered the vaccination failure, shingles and post herpetic neuralgia to be unrelated to Shingrix and Shingrix.   Additional Information: GSK Receipt Date: 06-JAN-2025 and 09-JAN-2025  This case was reported by a patient via interactive digital media. The patient got the second dose Shingrix vaccine in 2019 and was diagnosed with shingles on 24 August 2024. The blisters and scabbing finally cleared up in about 2 and a half to 3 weeks and had the post herpetic neuralgia.  The patient went to primary care physician and he prescribed gabapentin for the nerve pain.  It helps some but not for very long at a time. The patient was currently living on Advil liquigels and Tylenol rapid release.  Hopefully yours and the patient's would finally went away.  The patient had been told that the nerve pain could last for months even years after the rash/blistering clears up and goes away.  The commercials the patient had seen said that the vaccine was only effective in about 90 percent of people who get the vaccine, so he/she guess that he/she was in that 10 percent out of 100 percent who it did not help, since he/she got the 2 doses of Shingrix vaccine. This case was considered as suspected vaccination failure as details regarding time laboratory confirmation regarding shingles were unknown at the time of reporting.; Sender's Comments: Vaccination failure is a listed event which, due to the following criteria (insufficient information provided about laboratory confirmation of disease) is considered unrelated to GSK vaccine Shingrix.  Herpes zoster and Post herpetic neuralgia are unlisted events which are considered unrelated to GSK vaccine Shingrix.