Age: 74.0
Sex: F
Vaccine: COVID19
Symptoms: Anxiety, Condition aggravated, Eye irritation, Foreign body sensation in eyes, Sensory disturbance
Clinical narrative: Eyes feel gritty; It makes her tears burn her eyes and skin; It makes her tears burn her eyes and skin; 2 hours after taking it she was in worse shape than before she took it. It caused anxiety; she felt she was "sensitized; she was in worse shape than before she took it.; This spontaneous case was reported by a consumer and describes the occurrence of FOREIGN BODY SENSATION IN EYES (Eyes feel gritty), EYE IRRITATION (It makes her tears burn her eyes and skin), SKIN BURNING SENSATION (It makes her tears burn her eyes and skin), ANXIETY (2 hours after taking it she was in worse shape than before she took it. It caused anxiety) and SENSORY DISTURBANCE (she felt she was "sensitized) in a 74-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 prophylaxis. The occurrence of additional non-serious events is detailed below.    Co-suspect product included non-company product BUPROPION HYDROCHLORIDE for Depression.    The patient's past medical history included Thyroidectomy. Previously administered products included for Drug use for unknown indication: PRESERVISION, PRESERVISION, PRESERVISION, PRESERVISION and BACTRIM. Past adverse reactions to the above products included Anaphylactic reaction with BACTRIM; Eye irritation with PRESERVISION; Ocular hyperaemia with PRESERVISION; Skin burning sensation with PRESERVISION; and Skin irritation with PRESERVISION. Concurrent medical conditions included Post-traumatic stress disorder (post-traumatic stress disorder (PTSD)) and Reaction to excipient. Concomitant products included DIAZEPAM (VALIUM) for an unknown indication.   In February 2022, the patient received dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. In 2022, BUPROPION HYDROCHLORIDE (unknown route) dosage was changed to 100 milligram once a day. On an unknown date, the patient started BUPROPION HYDROCHLORIDE (unknown route) 300 milligram once a day. In 2022, the patient experienced FOREIGN BODY SENSATION IN EYES (Eyes feel gritty), EYE IRRITATION (It makes her tears burn her eyes and skin), SKIN BURNING SENSATION (It makes her tears burn her eyes and skin), ANXIETY (2 hours after taking it she was in worse shape than before she took it. It caused anxiety), SENSORY DISTURBANCE (she felt she was "sensitized) and CONDITION AGGRAVATED (she was in worse shape than before she took it.). The patient was treated with BUPROPION HYDROCHLORIDE (BUPROPION HCL XL) in 2023 at a dose of 150 milligram. At the time of the report, FOREIGN BODY SENSATION IN EYES (Eyes feel gritty), EYE IRRITATION (It makes her tears burn her eyes and skin), SKIN BURNING SENSATION (It makes her tears burn her eyes and skin) and ANXIETY (2 hours after taking it she was in worse shape than before she took it. It caused anxiety) had resolved and SENSORY DISTURBANCE (she felt she was "sensitized) and CONDITION AGGRAVATED (she was in worse shape than before she took it.) outcome was unknown.            The patient had PTSD from childhood, thyroid removed, issues with hydroxypropyl methyl cellulose (HPMCs) previously with sensitivities, and irritation, burning on face and eyes, redness of corner of her eyes, and felt sandy all the time with use of AREDS Preservation.   Concomitant products included unspecified thyroid medication. It was reported as taking for 15 to 20 years, relative to 18-JAN-2024, the patient started treatment with bupropion HCL 150 MG at 300 mg, 1x/day, via an unspecified route of administration for depression. After starting the product, the patient started to take the product situationally depending on what was happening for 2 to 3 (also reported as 3 to 6) months at a time. Then she tapered off them. In 2021, she took bupropion HCL, and it was fine. In February 2022, she started to have problems. She thought maybe the ingredients had changed. She realized they had not. The patient got Moderna vaccine which had many HPMCs. After that, she felt she was sensitized. Two hours after taking the very next prescription, she was in worse shape than before she took it. It caused anxiety. After she started having problems in 2022, the bupropion HCL dose was lowered to 100 mg, 1x/day to see if she reacted to it. Since the patient was doing okay on the 100 mg dose, on an unspecified date in probably March or April 2023, they raised the dose and she was prescribed bupropion HCl XL 150 mg, and it started bothering her again. Subsequently, the patient quit taking it. The patient tried to go back on it, but stopped taking it because she was almost worse off with anxiety after she took it than before she took it. She tried to use it a couple of times since, but she used it just briefly. As of 18-JAN-2024, treatment with bupropion HCL 150 mg and 100 mg and bupropion HCl XL were withdrawn, and the eyes feel gritty, tears burn eyes and skin, and anxiety were resolved when not taking HPMC containing products.