Age: 80.0
Sex: F
Vaccine: COVID19
Symptoms: Inflammatory marker increased, Infusion, Iron deficiency, Irritable bowel syndrome, Knee arthroplasty
Clinical narrative: She got her vaccine, and that went OK.  Then what appeared to her on 3/18/21 she felt a lump on the left side of the back of her neck.  Then on 3/20/21 after her shower her face was red and puffy and had diarrhea.  On 3/25/21 she called her PCP and told her that her BP was very high.  On 3/26/21 she had blood work done and the bump on her neck started to disappear on 3/27/21.  She had an apt with her PCP on 3/29/21 and she told them on 3/31/21 the bump had gone.  on 4/7/21 she was extremely exhausted, and on 4/8/21 she slept all day.  On 4/14/21 she had diarrhea again.  Her GI was acting up and she never associated it with the shot and she continued taking the vaccines.  Her PCP checked her out and she did not know what was going on with her.  She thinks she was given Pepto which did not help.  She continued taking her shots.  She completed 5 of them, and the last was 11/1/2022.  She is lactose intolerant, and she is assuming that she may have had something that she should not have eaten and that's the way she was treating it.  When her stomach got so very bad, and knew that things were not going well with her, the doctor said that she needed to see a gastroenterologist.  she suffered for a year with her GI symptoms, and then had a colonoscopy on 9/12/22 and that revealed that she had ulcerated pancolitis.  Her symptoms were diarrhea, progressed to bleeding, incontinence, chills.  She had to have an 4 iron infusion as she had iron deficiency, she had a calprotectin test and it was 962, when the normal is 50 or less, it is now 8000.   She was started with budesanine steroids for IBS, then she was given Mudecinine both of them worked for a little while, but not very long.  This is the go to drug for this particular disease but it did not work for her.  They kept giving her that and she continued to have enemas, and then she was started on Prednisone, which did help and she is on it still.  She was at Hospital 2 weeks ago as her condition was getting worse and she was given an IV and that helped her somewhat.  She was admitted on 10/17/23, and discharged on 10/21/2023.  She had a flex-sigmoidoscopy and showed that it was moderate in the sigmoid and severe chronic colitis in the rectum.  She has received 3 infusions of Remicade and the last one was on 10/18/23.  She is on a tapering dose of Prednisone now and goes for her next infusion on 11/15/23.  Her CRP and her ESR are now in the normal range where they were not.    On 3/17/23 she was on Intebio and that worked for her for 3 months and then it stopped working, which was very unfortunate, and she felt like she was normal again with that.    11/14/21 she had a total knee replacement and when she went back to her surgeon for her check up on her knee they checked the inflammation rate and it was high.  This was an indicator that something was wrong with her knee.  He aspirated them, it was not the knee that had inflammation and this is how this all started to come together.    Gastroelternolgist is Dr.   Her mother had lupus and her sister had rheumatoid arthritis, and she is thinking that there could have been something in her immune system that she had a tendency for something like this to happen and thinks it was triggered by this vaccine that happened to her.  She had never had a problem with anything like this prior to the vaccine.