Age: 70.0
Sex: F
Vaccine: TDAP, TDAP
Symptoms: Musculoskeletal pain, Oropharyngeal pain, Pain, Paralysis, Paranasal sinus discomfort
Clinical narrative: muscle tightening / muscles were so tense; Swelling all over her body; Nose started running; sore throat; headache; terrible sinus pressure; terrible sinus pressure and pain; chills; Could not move her arms up / lost mobility of her shoulders, arms, wrist, hands and fingers; Mostly sleep all the time; extreme fatigue; can't lift her cooking pots because her wrist are still weak; Hands get inflamed; Hands get inflamed and start pulsing; pain when trying to lift her shoulders; trouble climbing stairs; could not do her daily activities; was in terrible pain; totally paralyzed; This case was reported by a consumer via call center representative and described the occurrence of paralysis in a 70-year-old female patient who received DTPa (Reduced antigen) (Boostrix) (batch number HT479, expiry date 31st August 2021) for prophylaxis.   On 23rd February 2020, the patient received Boostrix. In February 2020, 1 week after receiving Boostrix, the patient experienced paralysis (serious criteria GSK medically significant), mobility decreased, somnolence, fatigue, weakness, inflammation localized, muscle cramp, shoulder pain, walking difficulty, activities of daily living impaired and pain. On 23rd February 2020, the patient experienced muscle tightness, swelling, runny nose, sore throat, headache, sinus pressure, sinus pain and chills. The patient was treated with prednisone and ibuprofen. On an unknown date, the outcome of the paralysis, muscle tightness, swelling, runny nose, sore throat, chills, mobility decreased, somnolence, activities of daily living impaired and pain were unknown and the outcome of the headache, sinus pressure, sinus pain, fatigue, weakness, inflammation localized, muscle cramp, shoulder pain and walking difficulty were not recovered/not resolved.   It was unknown if the reporter considered the paralysis, muscle tightness, swelling, runny nose, sore throat, headache, sinus pressure, sinus pain, chills, mobility decreased, somnolence, fatigue, weakness, inflammation localized, muscle cramp, shoulder pain, walking difficulty, activities of daily living impaired and pain to be related to Boostrix.  Additional information was provided as follows: The patient after receiving vaccine immediately experienced muscle tightening and swelling all over her body, her nose started running like a faucet, she developed a sore throat, headache, terrible sinus pressure and pain, and chills. A week later she became totally paralyzed, she could not move her arms up, was in terrible pain and would mostly sleep all the time. She could not move around her bed, she had to lay on her back because her muscles were so tense. She lost mobility of her shoulders, arms, wrist, hands and fingers. She experienced extreme fatigue and could not do her daily activities. She went to her doctor and was told she had a reaction to the Boostrix and was placed on a five week tapering dose of prednisone and then she started on buprofen. Till the time of reporting, the patient was still experiencing extreme fatigue, headaches, sinus pressure/pain, has trouble climbing stairs, can't lift her cooking pots because her wrist are still weak, still has pain when trying to lift her shoulders and when she walks her hands get inflamed and start pulsing. The patient was regaining movement in her fingers. She had seen a neurologist, rheumatologist and was currently receiving physical therapy. The reporter did not consent to follow up.