Age: 14.0
Sex: F
Vaccine: HPV4, MNQ, HPV4
Symptoms: Hypoaesthesia, Neuropathy peripheral, Paraesthesia, Vaccine positive rechallenge
Clinical narrative: Tingling of hands, legs and feet. Occasional headache. Had these symptoms after receiving each Gardasil injection , worse right after injection, improved with time, but not completely resolved.  5/29/2008 MR received from PCP In for 14yr WCC on 8/28/07.   Recently seen in ER for chest pain/heart racing and slowing. EKG reportedly normal.    Menactra and Gardasil given. Seen again 9/17/07 with N, V & D, body aches and pains and tingling everywhere. C/O h/a, fatigue and cough.  DX:  Headache, Sinusitis, Arthralgias. Gardasil # 3 given 3/11/08. Pt seen 4/16/08 with c/o tingling of hands and feet and headaches which began after Gardasil vax. DX:  Peripheral neuropathy.  Pt referred to neurology but did not go as symptoms were resolving somewhat although not completely gone as off 8/8/08. This is in follow-up to report(s) previously submitted on 5/14/2008. Information has been received from a physician, concerning a 14 year old female patient, who on an unknown date was vaccinated with the first dose of GARDASIL, and subsequently developed tingling and numbness in her arm. Following the vaccination with the second dose (date not specified), the patient again developed numbness and tingling in her arm, as well as peripheral neuropathy. Following the vaccination with the third dose (date not specified), she again developed peripheral neuropathy. The physician sent her to a neurologist (details not provided). At the time of this report, the patient had not recovered from peripheral neuropathy. Follow up information was received on 30-MAY-2008. The registered nurse reported that the patient was vaccinated with the first dose of GARDASIL lot 658556/1060U on 28-AUG-2007. She received the second dose of GARDASIL lot 658563/1063U on 30-OCT-2007. She received the third dose of GARDASIL lot 668387/1967U on 11-MAR-2008. The registered nurse reported that on 16-APR-2008 the patient was seen by the physician. The patient's mother stated that after the first dose of GARDASIL lot 658556/1060U she had headaches sometimes and that she developed tingling and numbness in her arm. It was reported that after the patient received the second and third dose of GARDASIL lot 658563/1063U and lot 660387/1067U, the patient again developed tingling and numbness in her arm and peripheral neuropathy. The registered nurse stated that the patient's "lab work" was normal. On 19-APR-2008, the patient was referred to a pediatric neurologist. The patient was scheduled to see the neurologist on 08-JUL-2008. The registered nurse did not know if the patient had recovered. Additional information has been requested. Follow-up information was received on 20-JUN-2008. The registered nurse reported that the patient also recovered on 28-AUG-2007 the first dose of menigococcal ACTW conj vaccine (dip toxoid) lot U2395BA via IM in the right arm (deltoid). Other concomitant vaccination included the third dose via IM in the right arm (deltoid) of FLUZONE lot U2451AA on 10-OCT-2007. It was also reported that the patient has a history of obesity, acne, dysmenorrhoea, scoliosis and chest pain. The patient also had laboratory work done including BMP, Ca+, folate, B12, magnesium, all within normal limits. The patient is being treated for face with "benzaclin CaCl topically." The patient's outcome is unknown. Additional information has been requested.