Sex: U
Vaccine: UNK
Symptoms: Vaccination failure
Clinical narrative: This case was reported in a literature article and described the occurrence of suspected vaccination failure in a adult subject who received inactivated trivalent influenza vaccine for prophylaxis. On an unknown date, unknown after receiving inactivated trivalent influenza vaccine, the subject developed vaccination failure. Serious criteria included hospitalization and GSK medically significant. Additional event(s) included influenza with serious criteria of hospitalization. The outcome of vaccination failure was unknown. The outcome(s) of the additional event(s) included influenza (unknown). The investigator considered that there was a reasonable possibility that the vaccination failure and influenza may have been caused by inactivated trivalent influenza vaccine. Relevant Tests: Laboratory tests were performed on unspecified dates between 2012 and 2015. The patient's nasopharyngeal swab was collected, and reverse transcriptase polymerase chain reaction was performed (rRT-PCR) for the detection of influenza. The patient was found to be positive with influenza infection (unspecified). Diagnostic results (unless otherwise stated, normal values were not provided):  On an unknown date, Influenza virus test result was positive. On an unknown date, Polymerase chain reaction result was see text unknown. Additional information was provided. This case was reported in a literature article and described the suspected vaccination failure in a patient aged between 18 and 80 years of unspecified gender who was vaccinated with unspecified inactivated trivalent influenza vaccine (IIV3) (manufacturer unknown) for prophylaxis. This case corresponds to supplementary table C reported in this literature article. The patient was part of the study that estimated influenza vaccine effectiveness (IVE) against intensive care unit (ICU) influenza and examined other indicators of severe outcomes among vaccinated and unvaccinated influenza positive patients as part of the Influenza and Vaccine Effectiveness Research and Surveillance (IVERS) project, which prospectively enrolled hospitalized adults from 2012 to 2015. The patient had no chronic conditions. No information on patient's family history or concomitant condition was provided. On an unspecified date, the patient had received unspecified inactivated trivalent influenza vaccine (IIV3) (administration route and site unspecified, dosage unknown; batch number not provided). The age of vaccination was not provided. On an unspecified date between 2012 and 2015, an unknown period after vaccination, the patient was admitted to intensive care unit and diagnosed with acute respiratory infection (ARI). The patient's nasopharyngeal swab was collected, and reverse transcriptase polymerase chain reaction was performed (rRT-PCR) for the detection of influenza. The patient was found to be positive with influenza infection (unspecified). This case has been considered as suspected vaccination failure being time to onset was unknown. This case has been considered serious due to suspected vaccination failure/hospitalisation. Treatment was unknown. The outcome of the event was not provided. The author did not comment on relationship between the event of influenza infection and unspecified inactivated trivalent influenza vaccine (IIV3). The author concluded "This study found that influenza vaccines offer significant protection against influenza-associated ICU admission and, among hospitalized patients, significantly reduced the odds of ICU admission among those infected. If future research confirms that influenza vaccines can attenuate severe influenza disease and/or that IVE is indeed higher against ICU in?uenza than is observed in most ambulatory or general wards (GW) hospital settings, these findings could enhance the perceived value of influenza vaccination for the public and substantially improve the cost-effectiveness of influenza vaccine programs given the high costs of ICU care". Lab Comments: Laboratory tests were performed on unspecified dates between 2012 and 2015. The patient's nasopharyngeal swab was collected, and reverse transcriptase polymerase chain reaction was performed (rRT-PCR) for the detection of influenza. The patient was found to be positive with influenza infection (unspecified).