Age: 52.0
Sex: M
Vaccine: COVID19
Symptoms: Lumbar puncture, Quadriplegia
Clinical narrative: He is 95% paralyzed in his arms and legs / At present, his left lower leg is paralyzed / It started as loss of feeling on his right leg and left foot and went up to his back / he has limited sensation on the left arm; This spontaneous case was reported by a consumer and describes the occurrence of QUADRIPLEGIA (He is 95% paralyzed in his arms and legs / At present, his left lower leg is paralyzed / It started as loss of feeling on his right leg and left foot and went up to his back / he has limited sensation on the left arm) in a 52-year-old male patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 047B21A and 017B21A) for COVID-19 vaccination.     Previously administered products included for Product used for unknown indication: Flu shot (Patient received last flu shot in 2019) in 2019. Past adverse reactions to the above products included No adverse event with Flu shot. Concurrent medical conditions included Hypertension (He had high blood pressure but is not taking any medications) and Hepatitis C (He had Hepatitis C but is not taking any medications).   On 06-Apr-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 04-May-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On an unknown date, the patient experienced QUADRIPLEGIA (He is 95% paralyzed in his arms and legs / At present, his left lower leg is paralyzed / It started as loss of feeling on his right leg and left foot and went up to his back / he has limited sensation on the left arm) (seriousness criteria hospitalization and medically significant). The patient was hospitalized from 27-Jul-2021 to 18-Aug-2021 due to QUADRIPLEGIA. At the time of the report, QUADRIPLEGIA (He is 95% paralyzed in his arms and legs / At present, his left lower leg is paralyzed / It started as loss of feeling on his right leg and left foot and went up to his back / he has limited sensation on the left arm) had not resolved.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On 27-Jul-2021, Lumbar puncture: r/o guillain barre, west nile, multiple sclerosis He had 3 lumbar punctures; 2 were successful and one was unsuccessful. These helped his doctors determine his condition. They were able to rule out Guillain Barre Syndrome, West Nile virus and Multiple Sclerosis.     For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown), the reporter did not provide any causality assessments.   He is 5'10".He had no history of allergies. He did not have any history of COVID-19 prior to or after getting the vaccine.He did not receive any concomitant vaccination with the COVID-19 vaccine.On 27-Jul-2021, several tests were done. He was sent to rehab for 2 weeks before being sent home. He had a number of steroid shots, plasma exchange and IVIG treatment which were unsuccessful.He had a suprapubic catheter.  COMPANY COMMENT : This spontaneous case concerns 52-year-old patient, with concurrent medical history of Hypertension (He had high blood pressure but is not taking any medications) is reported, who experienced unexpected serious event of quadriplegia (seriousness criteria hospitalization and medically significant) which occurred unspecified days after a dose (dose number not specified) of mRNA-1273 vaccine. It is reported that on patient got hospitalized and he had 3 lumbar punctures; 2 were successful and one was unsuccessful, they were able to rule out Guillain Barre Syndrome, West Nile virus and Multiple Sclerosis and treated with number of steroid shots, plasma exchange and IVIG treatment which were unsuccessful. Patient is on suprapubic catheter. Patient was sent to rehabilitation center for 2 weeks before being sent home. Concurrent medical history Hypertension (He had high blood pressure but is not taking any medications) remains as confounding for the events. The benefit-risk relationship of mRNA-1273 is not affected by this report.; Sender's Comments: This spontaneous case concerns 52-year-old patient, with concurrent medical history of Hypertension (He had high blood pressure but is not taking any medications) is reported, who experienced unexpected serious event of quadriplegia (seriousness criteria hospitalization and medically significant) which occurred unspecified days after a dose (dose number not specified) of mRNA-1273 vaccine. It is reported that on patient got hospitalized and he had 3 lumbar punctures; 2 were successful and one was unsuccessful, they were able to rule out Guillain Barre Syndrome, West Nile virus and Multiple Sclerosis and treated with number of steroid shots, plasma exchange and IVIG treatment which were unsuccessful. Patient is on suprapubic catheter. Patient was sent to rehabilitation center for 2 weeks before being sent home. Concurrent medical history Hypertension (He had high blood pressure but is not taking any medications) remains as confounding for the events. The benefit-risk relationship of mRNA-1273 is not affected by this report.