Sex: M
Vaccine: COVID19
Symptoms: C-reactive protein, Cough, Ejection fraction, Electrocardiogram, Magnetic resonance imaging
Clinical narrative: acute myocarditis 3 days after 2nd dose; Fever on day +1; Cough on day +1; This is a literature report from License Party for the following literature source(s).  A 26-year-old male patient received bnt162b2 (BNT162B2), as dose 2, single (Batch/Lot number: unknown) for covid-19 immunisation. The patient's relevant medical history and concomitant medications were not reported. Vaccination history included: Covid-19 vaccine (DOSE 1, SINGLE), for COVID-19 immunization. The following information was reported: MYOCARDITIS (hospitalization, medically significant), 3 days after the suspect product(s) administration, outcome "recovered", described as "acute myocarditis 3 days after 2nd dose"; PYREXIA (non-serious), 1 day after the suspect product(s) administration, outcome "unknown", described as "Fever on day +1"; COUGH (non-serious), 1 day after the suspect product(s) administration, outcome "unknown", described as "Cough on day +1". The patient underwent the following laboratory tests and procedures: C-reactive protein: 1; Ejection fraction: 60 %, notes: inferior wall hypokinesia; Electrocardiogram: results below, notes: Inferolateral ST elevation; Magnetic resonance imaging: results below, notes: Edema, delayed enhancement, pericardial effusion; SARS-CoV-2 test: negative; Troponin: 11; 100. Therapeutic measures were taken as a result of myocarditis, pyrexia, cough.  Clinical course: Clinical course: The article describes 8 patients who were hospitalized with chest pain and who were diagnosed with myocarditis by laboratory and cardiac magnetic resonance imaging within 2 to 4 days of receiving either the BNT162b2 or mRNA-1273 vaccine. Patients provided written informed consent, and the collection of clinical cases followed local Institutional Review Board requirements. The data that support the findings of this study are available from the corresponding author on reasonable request. Two of the patients (patients 3 and 4) had previously been infected by SARS-CoV-2 without need for hospitalization. All individuals were otherwise healthy males between the ages of 21 and 56 years. All but 1 patient developed symptoms after their second dose. Systemic symptoms began within 24 hours after vaccine administration in 5 out of 8 patients, with chest pain presenting between 48 and 96 hours later. Chest pain was most commonly described as constant, nonpositional, and nonpleuritic (only patient 7 reported pericardial pain), consistent with acute myocarditis mainly without pericardial involvement. Troponin values were elevated in all individuals and appeared to peak the day after admission, whereas no patient had eosinophilia. All patients were tested and were negative for SARS-CoV-2. Left ventricular ejection fraction was reduced (<50%) in 2 of 8 (25%) patients with a median left ventricular ejection fraction of 51.5% (first to third quartile, 48% to 59%). All patients had resolution of their chest pain, were discharged from the hospital in stable condition, and were alive with preserved left ventricular ejection fraction at last contact. The patient was days in intensive care; no inotropes or mechanical circulatory support; discharged stable. Therapeutic measures included colchicine.  SUSPECT PRODUCT is under agreement with BIONTECH SE.; Sender's Comments: Based on the information available, a possible contributory role of BNT162B2 cannot be excluded for the reported event Myocarditis.  The impact of this report on the benefit/risk profile of the Pfizer product is evaluated as part of Pfizer procedures for safety evaluation, including the review and analysis of aggregate data for adverse events. Any safety concern identified as part of this review, as well as any appropriate action in response, will be promptly notified to Regulatory Authorities, Ethics Committees and Investigators, as appropriate.