Age: 36.0
Sex: F
Vaccine: COVID19, COVID19
Symptoms: Mast cell activation syndrome, Mouth ulceration, Muscle atrophy, Myalgia, Nasal ulcer
Clinical narrative: rapid muscle mass loss; tachycardia; hypertension; anxiety; depression; palpitations; ADHD; ptsd; insomnia; shingles; rash; tremors/zaps and shocks of fingers / Shaking; internal vibrations; shob on exertion; pots; dysautonomia; head pressure; hot flashes; cold chills; tinnitus; runny nose; parenthesis; hair loss; dry eyes and mouth; dry eyes and mouth; mouth and nasal ulcers; mouth and nasal ulcers; vertigo; unable to control body temperature; swollen painful joints; gi problems; chest pains; cellulitis; mcas; neuropathy in hands and feet; dizziness; fatigue; pain in muscles and joints; pain in muscles and joints; headache; nausea; syncope / near syncope; Interchange of vaccine products; This is a spontaneous report received from contactable reporter(s) (Nurse). The reporter is the patient.  A 36-year-old female patient (not pregnant) received BNT162b2 (BNT162B2), on 29Dec2021 at 15:45 as dose 3 (booster), single (Lot number: FH8027) at the age of 36 years, in right arm for covid-19 immunisation. The patient's relevant medical history included: "Pollen allergy" (unspecified if ongoing). Concomitant medication(s) included: CLARITIN [LORATADINE]. Vaccination history included: moderna (DOSE 1, SINGLE, Batch/Lot No: 011J20A, Anatomical location: Arm Right), administration date: 23Dec2020, when the patient was 35-year-old, for COVID-19 immunization; moderna (DOSE 2, SINGLE, Batch/Lot No: 028L20A, Anatomical location: Arm Right), administration date: 25Jan2021, when the patient was 35-year-old, for COVID-19 immunization. The following information was reported: INTERCHANGE OF VACCINE PRODUCTS (medically significant) with onset 29Dec2021 at 15:45, outcome "unknown"; DIZZINESS (disability) with onset 29Dec2021 at 23:45, outcome "not recovered"; FATIGUE (disability) with onset 29Dec2021 at 23:45, outcome "not recovered"; HEADACHE (disability) with onset 29Dec2021 at 23:45, outcome "not recovered"; NAUSEA (disability) with onset 29Dec2021 at 23:45, outcome "not recovered"; MYALGIA (disability), ARTHRALGIA (disability) all with onset 29Dec2021 at 23:45, outcome "not recovered" and all described as "pain in muscles and joints"; SYNCOPE (disability, medically significant) with onset 29Dec2021 at 23:45, outcome "not recovered", described as "syncope / near syncope"; ATTENTION DEFICIT HYPERACTIVITY DISORDER (disability) with onset Jan2022, outcome "not recovered", described as "ADHD"; ANXIETY (disability) with onset Jan2022, outcome "not recovered"; CELLULITIS (disability, medically significant) with onset Jan2022, outcome "not recovered"; CHEST PAIN (disability) with onset Jan2022, outcome "not recovered", described as "chest pains"; CHILLS (disability) with onset Jan2022, outcome "not recovered", described as "cold chills"; DEPRESSION (disability) with onset Jan2022, outcome "not recovered"; DRY EYE (disability), DRY MOUTH (disability) all with onset Jan2022, outcome "not recovered" and all described as "dry eyes and mouth"; AUTONOMIC NERVOUS SYSTEM IMBALANCE (disability) with onset Jan2022, outcome "not recovered", described as "dysautonomia"; GASTROINTESTINAL DISORDER (disability) with onset Jan2022, outcome "not recovered", described as "gi problems"; ALOPECIA (disability) with onset Jan2022, outcome "not recovered", described as "hair loss"; HEAD DISCOMFORT (disability) with onset Jan2022, outcome "not recovered", described as "head pressure"; HOT FLUSH (disability) with onset Jan2022, outcome "not recovered", described as "hot flashes"; HYPERTENSION (disability) with onset Jan2022, outcome "not recovered"; INSOMNIA (disability) with onset Jan2022, outcome "not recovered"; NERVOUSNESS (disability) with onset Jan2022, outcome "not recovered", described as "internal vibrations"; MAST CELL ACTIVATION SYNDROME (disability, medically significant) with onset Jan2022, outcome "not recovered", described as "mcas"; MOUTH ULCERATION (disability), NASAL ULCER (disability) all with onset Jan2022, outcome "not recovered" and all described as "mouth and nasal ulcers"; NEUROPATHY PERIPHERAL (disability, medically significant) with onset Jan2022, outcome "not recovered", described as "neuropathy in hands and feet"; PALPITATIONS (disability) with onset Jan2022, outcome "not recovered"; PARAESTHESIA (disability) with onset Jan2022, outcome "not recovered", described as "parenthesis"; POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME (disability) with onset Jan2022, outcome "not recovered", described as "pots"; POST-TRAUMATIC STRESS DISORDER (disability) with onset Jan2022, outcome "not recovered", described as "ptsd"; MUSCLE ATROPHY (disability) with onset Jan2022, outcome "not recovered", described as "rapid muscle mass loss"; RASH (disability) with onset Jan2022, outcome "not recovered"; RHINORRHOEA (disability) with onset Jan2022, outcome "not recovered", described as "runny nose"; HERPES ZOSTER (disability) with onset Jan2022, outcome "not recovered", described as "shingles"; DYSPNOEA (disability) with onset Jan2022, outcome "not recovered", described as "shob on exertion"; JOINT SWELLING (disability) with onset Jan2022, outcome "not recovered", described as "swollen painful joints"; TACHYCARDIA (disability) with onset Jan2022, outcome "not recovered"; TINNITUS (disability) with onset Jan2022, outcome "not recovered"; TREMOR (disability) with onset Jan2022, outcome "not recovered", described as "tremors/zaps and shocks of fingers / Shaking"; BODY TEMPERATURE ABNORMAL (disability) with onset Jan2022, outcome "not recovered", described as "unable to control body temperature"; VERTIGO (disability) with onset Jan2022, outcome "not recovered". The event "shob on exertion" required emergency room visit. The events "syncope / near syncope", "cellulitis", "mcas", "neuropathy in hands and feet", "dizziness", "fatigue", "pain in muscles and joints", "headache", "nausea", "rapid muscle mass loss", "tachycardia", "hypertension", "anxiety", "depression", "palpitations", "adhd", "ptsd", "insomnia", "shingles", "rash", "tremors/zaps and shocks of fingers / shaking", "internal vibrations", "pots", "dysautonomia", "head pressure", "hot flashes", "cold chills", "tinnitus", "runny nose", "parenthesis", "hair loss", "dry eyes and mouth", "mouth and nasal ulcers", "vertigo", "unable to control body temperature", "swollen painful joints", "gi problems" and "chest pains" required physician office visit and emergency room visit. The patient underwent the following laboratory tests and procedures: Body temperature: (Jan2022) unable to control body temperature. Therapeutic measures were taken as a result of syncope, cellulitis, mast cell activation syndrome, neuropathy peripheral, dizziness, fatigue, myalgia, arthralgia, headache, nausea, muscle atrophy, tachycardia, hypertension, anxiety, depression, palpitations, attention deficit hyperactivity disorder, post-traumatic stress disorder, insomnia, herpes zoster, rash, tremor, nervousness, dyspnoea, postural orthostatic tachycardia syndrome, autonomic nervous system imbalance, head discomfort, hot flush, chills, tinnitus, rhinorrhoea, paraesthesia, alopecia, dry eye, dry mouth, mouth ulceration, nasal ulcer, vertigo, body temperature abnormal, joint swelling, gastrointestinal disorder, chest pain.  Clinical course: The patient was not pregnant at the time of vaccination. The patient had no known allergies. No other vaccine in four weeks. No covid prior vaccination and covid not tested post vaccination. Facility type vaccine: Hospital. Stated that, 8 hours post vaccination, the patient experienced dizziness, fatigue, pain in muscles and joints, headache, nausea and syncope. Two weeks later rapid muscle mass loss, tachycardia, hypertension, anxiety, depression, near syncope, palpitations, adhd, ptsd, insomnia each month new symptoms appeared including shingles, cellulitis, rash, tremors, internal vibrations, zaps and shocks of fingers, shob on exertion, pots, mcas, dysautonomia, head pressure, hot flashes, cold chills, shaking, tinnitus, runny nose, neuropathy in hands and feet, parenthesis, hair loss, dry eyes and mouth, mouth and nasal ulcers, vertigo, unable to control body temperature, swollen painful joints, GI problems and chest pains. All new onset of symptoms and diagnosis. AE resulted in: (Doctor or other healthcare professional office clinic visit, Emergency Room department or urgent care, Disability or permanent damage).; Sender's Comments: Based on the available information in the case, an association between the reported events and The suspected drug cannot be ruled out.  The impact of this report on the benefit/risk profile of the Pfizer product is evaluated as part of Pfizer procedures for safety evaluation, including the review and analysis of aggregate data for adverse events. Any safety concern identified as part of this review, as well as any appropriate action in response, will be promptly notified to regulatory authorities, Ethics Committees, and Investigators, as appropriate.