Sex: F
Vaccine: COVID19
Symptoms: Autonomic nervous system imbalance, Eye disorder, Full blood count, Guillain-Barre syndrome, Metabolic function test
Clinical narrative: flareup of her guillain-barre; Her eyes, she had the miller fisher variant and her eyes got really wonky again after the first vaccine, her reflexes went away and that was it, balance was off; Has autonomic dysfunction and had an increase of that as well; Her eyes, she had the miller fisher variant and her eyes got really wonky again; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP) from medical information team. The reporter is the patient.  A 54-year-old female patient received BNT162b2 (BNT162B2), in Apr2021 as dose 1, single (Batch/Lot number: unknown) for covid-19 immunisation. The patient's relevant medical history included: "Guillen Guillain-Barre syndrome" (unspecified if ongoing); "Myasthenia Gravis" (unspecified if ongoing); "Hashimoto disease" (unspecified if ongoing); "overweight" (unspecified if ongoing); "Covid", start date: Mar2020 (unspecified if ongoing), notes: Had first symptoms of Covid Mar2020. Concomitant medication(s) included: METHYLPREDNISOLONE taken for guillain-barre syndrome, myasthenia gravis. The following information was reported: GUILLAIN-BARRE SYNDROME (medically significant), outcome "unknown", described as "flareup of her guillain-barre"; MILLER FISHER SYNDROME (medically significant), outcome "unknown", described as "Her eyes, she had the miller fisher variant and her eyes got really wonky again after the first vaccine, her reflexes went away and that was it, balance was off"; AUTONOMIC NERVOUS SYSTEM IMBALANCE (non-serious), outcome "unknown", described as "Has autonomic dysfunction and had an increase of that as well"; EYE DISORDER (non-serious), outcome "unknown", described as "Her eyes, she had the miller fisher variant and her eyes got really wonky again". The patient underwent the following laboratory tests and procedures: Full blood count: good, notes: Tests: Had a CBC and CMP panel that came back good, everything was good; Metabolic function test: good, notes: Tests: Had a CBC and CMP panel that came back good, everything was good.  Clinical course: Flareup of Guillain-Barre: Clarified that caller had flare up with each dose of Covid vaccine she received. The Bivalent vaccine was the most minimal reaction of them all. Each reaction lasted a good month or 2. The first experience was the worst. Even her reflexes went out on her. Reflexes reduced and her balance was off. Her eyes, she had the miller fisher variant and her eyes got really wonky again. That hadn't happened in almost 30 years. Clarified that after the first vaccine, her reflexes went away and that was it. That was the only time she lost her reflexes. With the other shots, her reflexes stayed stable. Her eyes are wonky and her balance is wonky. Has autonomic dysfunction and had an increase of that as well. It was the only the first shot, where her reflexes went away, along with the other symptoms. Had first symptoms of Covid Mar2020. Was having a Myasthenia flare up and also getting Guillain-Barre symptoms with it.   The information on the batch/lot number for BNT162b2 has been requested and will be submitted if and when received.