Sex: F
Vaccine: VARZOS
Symptoms: Neuralgia, Pain, Rash
Clinical narrative: Broke out in a Shingles rash 2 days following both injections / Shingles rash on my hip and back; Broke out in a Shingles rash 2 days following both injections / Shingles rash on my hip and back; Mild muscle aches in neck and back/Deep muscle pain; Unbearably painful; shivering intensely; Nerve pain in my ears and spine; Intense nausea; Unable to stand steady or move; injury; Old injuty flareups; General debilitating exhaustion and weakness.; Exhaustion- fatigue; This case was reported by a consumer and described the occurrence of shingles in a 65-year-old female patient who received Herpes zoster (Shingrix) for prophylaxis.   The patient's past medical history included chickenpox (recurring monthly for 25 year), post-traumatic stress disorder, shingles (20 years ago) and cytomegalovirus infection. Previously administered products included Shingrix with an associated reaction of discomfort (after 1st dose patient experienced discomfort, pain, aches, tiredness, and nausea refer case US2020AMR211677) and antiviral (took a few monthly doses of an antiviral to manage breakouts of post-traumatic stress disorder (PTSD)).   On an unknown date, the patient received the 2nd dose of Shingrix. On an unknown date, 2 days after receiving Shingrix, the patient experienced shingles, rash, muscle pain, pain, chills, nerve pain, nausea, mobility decreased, injury, condition aggravated, weakness and exhaustion. The patient was treated with acyclovir. Rechallenge with Shingrix was positive. On an unknown date, the outcome of the shingles, rash, muscle pain, pain, chills, nerve pain, nausea, mobility decreased, injury, condition aggravated, weakness and exhaustion were unknown.   It was unknown if the reporter considered the shingles, rash, muscle pain, pain, chills, nerve pain, nausea, mobility decreased, injury, condition aggravated, weakness and exhaustion to be related to Shingrix.  .  Additional details were provided as follows: The age at vaccination was not reported. The reporter wanted to report what she believed to be an adverse event.  Mild muscle aches in neck and back. The patient went back for the 2nd dose of Shingrix two months later from 1st dose and the reactions were unbearably painful, shivering intensely, deep muscle pain, nerve pain in ears and spine, intense nausea, unable to stand steady or move about without severe discomfort.  The patient had old injury flare-ups and a general debilitating exhaustion and weakness.  The patient just thought reported of severe reaction after 2nd shot.  Pharmacist did not show her the box, and there was some deliberation on whether he had it available and that some had to be sent back which depleted his inventory but he was able to administer. The patient mother had Rheumatoid arthritis (RA) the patient also had the factor but it's not active.  The patient had been battling recurring monthly trunk located chicken pox for 25 years after an initial stressful PTSD event for which I take a few monthly doses of an antiviral to manage breakouts.  May be due to stress or one physician said they happen in some women around their cycles. This was just a report; symptoms were lifting with medication for pain. Again reported that after receiving 2nd doses of the Shingrix the patient broke out in a Shingles rash 2 days following the injections. She had recurrent viral attacks (Shingles) on right hip from a stressful event 20 years ago.  The patient was taking acyclovir to manage the outbreak as done for 20 years.  It was her hope the vaccine would prevent future breakouts since the acyclovir in her case seems like a life long medication.  It's odd, in her case it's almost a monthly occurrence about 30 days apart and also in between with added stress of any kind both physical and emotional. Most doctors were sort of baffled, her original diagnosis was cytomegalovirus for which the patient was told there was no cure. Following up with a specialist, she just looked at me and said he did not have that.  Her family Doctor prescribed acyclovir as a prophylaxis for breakouts but she only take it until symptoms disappear and until the next occurrence. She just thought it odd the vaccine, being recombant, through the severity of side effects (she had the g3 level of all the side effects for 48 hours and then fortunately bounced back with the usual Shingles rash on her hip and back to taking acyclovir to manage as usual. It was her hope and prayer she never get a full blown event like the symptoms from the shot again after receiving the full vaccine or the actual severity of the classic Shingles, the type that wraps around the torso and effects the whole body.  The patient just hope that whatever she have eventually goes always completely.; Sender's Comments:  US-GLAXOSMITHKLINE-US2020AMR211677:same patient, 1st dose