Age: 84.0
Sex: M
Vaccine: COVID19
Symptoms: COVID-19, SARS-CoV-2 test
Clinical narrative: Still positive for Covid after completing Paxlovid; This spontaneous case was reported by a patient family member or friend and describes the occurrence of COVID-19 (Still positive for Covid after completing Paxlovid) in an 84-year-old male patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 prophylaxis.     No Medical History information was reported.   On an unknown date, the patient received fourth dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On an unknown date, received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form, second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form and first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On an unknown date, the patient experienced COVID-19 (Still positive for Covid after completing Paxlovid). The patient was treated with NIRMATRELVIR, RITONAVIR (PAXLOVID) (oral) from 16-Aug-2022 to 20-Aug-2022 for COVID-19, at a dose of 1 dosage form twice a day. At the time of the report, COVID-19 (Still positive for Covid after completing Paxlovid) had not resolved.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On an unknown date, SARS-CoV-2 test: (Positive) Positive.         Patient ethnicity was reported as white.  No concomitant medication was reported by reporter.  Patient dose of paxlovid was double the dose that caller received which was 150 mg. Caller was unable to confirm patient exact dose. Patient was taking paxlovid in morning and evening twice a day, 5 day supply.  Company comment: This spontaneous case report concerns an 84-year-old male patient with no medical history provided, who experienced non-serious unexpected event of special interest - COVID-19. Reportedly, the patient developed COVID-19 after he had received a total of four doses of the mRNA-1273 vaccine (first, second and two booster doses), however, the exact temporal relationship between last vaccination and event occurrence cannot be determined, since date of vaccination and event start date were not provided. The patient was treated with Paxlovid for five days, however, after completing therapy, the patient was still positive for COVID-19. No further details were available for medical assessment. The patient's elderly age remains a significant confounding factor, having in mind that among elderly population clinical course of COVID-19 infection, as well as recovery,  are often prolonged. The benefit-risk relationship of mRNA 1273 vaccine is not affected by this report.   This case was linked to US-MODERNATX, INC.-MOD-2022-640719 (E2B Linked Report).; Sender's Comments: This spontaneous case report concerns an 84-year-old male patient with no medical history provided, who experienced non-serious unexpected event of special interest - COVID-19. Reportedly, the patient developed COVID-19 after he had received a total of four doses of the mRNA-1273 vaccine (first, second and two booster doses), however, the exact temporal relationship between last vaccination and event occurrence cannot be determined, since date of vaccination and event start date were not provided. The patient was treated with Paxlovid for five days, however, after completing therapy, the patient was still positive for COVID-19. No further details were available for medical assessment. The patient's elderly age remains a significant confounding factor, having in mind that among elderly population clinical course of COVID-19 infection, as well as recovery,  are often prolonged. The benefit-risk relationship of mRNA 1273 vaccine is not affected by this report. US-MODERNATX, INC.-MOD-2022-640719:Wife's case