Age: 22.0
Sex: F
Vaccine: COVID19, COVID19
Symptoms: Anaphylactic reaction, Anaphylactic shock, Asthma, Blood count abnormal, Body height
Clinical narrative: face and neck swells; face and neck swells; Tachycardia; feels like she is having an asthma attack.; blotch; blood counts continue to become worse; asthma worse; White blood cell counts are all elevated; A lot of bone pain; some trouble breathing; chest pain; dark purple on face; Ginormous welts/Rash or welt 1.5 inches by 1 inch on cheek; Itching in back of throat; anaphylactic reaction; anaphylactic shock; ginormous rash on her daughter's face that comes and goes and then it will be on her chest , face, neck and shoulders and migrates wherever; throat feels tight; This is a spontaneous report from a contactable consumer (patient's mother) and consumer (patient) via a Pfizer-Sponsored Program, . A 22-year-old female patient received the first dose of BNT162B2 (PFIZER-BIONTECH COVID-19 MRNA VACCINE; solution for injection) via an unspecified route of administration on 17Apr2021 at 09:10 (at the age of 22-years-old) as a single dose in the right arm for COVID-19 immunization. Medical history included penicillin allergy from an unspecified date and unspecified if ongoing, asthma from an unspecified date (diagnosed at 4 years old and it is usually controlled with medications) and ongoing and Ehlers-Danlos syndrome from 2019 and ongoing. Concomitant medications were reported as none. The patient did not receive any additional vaccines on the same date as the COVID-19 vaccination and did not receive any vaccinations within 4 weeks prior to the COVID-19 vaccination. The patient previously received the flu shot on an unspecified date for immunization and experienced allergic to flu shot preservative and the patient previously received Biaxin on an unspecified date for an unspecified indication and experienced allergy. On 17Apr2021 at 09:12 the patient experienced anaphylactic reaction and anaphylactic shock; on 17Apr2021 the patient experienced throat feels tight, ginormous rash on her daughter's face that comes and goes and then it will be on her chest , face, neck and shoulders and migrates wherever; on 18Apr2021 the patient experienced ginormous welts/rash or welt 1.5 inches by 1 inch on cheek, itching in back of throat; on 20Apr2021 the patient experienced dark purple on face; on 24Apr2021 the patient experienced some trouble breathing and chest pain; on 25Apr2021 the patient experienced a lot of bone pain; on 26Apr2021 the patient experienced white blood cell counts are all elevated and on unspecified dates the patient experienced face and neck swells, tachycardia, feels like she is having an asthma attack, blotch, blood counts continue to become worse and asthma worse. The reporter called to report that her daughter received the first dose of the COVID-19 vaccine on 17Apr2021 and that her side effects started two minutes later (also reported as 4 minutes later). The patient experienced anaphylaxis and anaphylactic shock. She stated that her daughter continued to have anaphylactic reactions and had to go to the hospital every day since then. The clinical course was reported as follows: her daughter and her husband went to get the vaccine together on 17Apr2021. They went to a facility giving the Pfizer vaccine, and the reporter stated that her daughter was asked, and she did tell them, that she could not receive the flu vaccine that had the additives in it because she was allergic to it. The reporter stated that her daughter was not taking the flu shot for years. She stated that her daughter was allergic to Biaxin but could take Zithromax because of the different additives. They had no idea what the preservative was, but it was obviously in the flu shot so they stopped getting the flu shot until they stopped putting the preservative in the vaccine. The reporter stated that her daughter received the COVID-19 vaccine and within two minutes her daughter told her dad that she was having a hard time breathing. Her daughter walked over to the city EMS who were on site and told them that she was having a hard time breathing. They treated her and then took her to hospital via ambulance. She was treated at the hospital and they were hesitant to discharge her because they were worried about her bounce back. This was exactly what has happened. Every night since the vaccine she has had to take her daughter into the hospital. Every day was a nightmare of either EpiPen injections, Tagamet, Benadryl or prednisone and ended up in the ER every day, where they give her IV Benadryl and send her home. The caller stated that her daughter's symptoms start with ginormous welts and then an itching to the back of the throat. She had seen a ginormous rash on her daughter's face that came and went and then it would be on her chest, face, neck and shoulders and migrated wherever. She saw dark purple on her daughter's face yesterday before she went to the ER. Her skin will blotch, and she will say that her throat feels tight like when she had a reaction to penicillin. She stated that her daughter used to get this when she they would give her penicillin; she would have that reaction every time she got penicillin and they finally said she was allergic to it. The caller states that after those symptoms started, she called EMS and they took her to a hospital. The caller stated she took her daughter to another hospital and they medicated her with IV Benadryl and fluids. Her primary care doctor told the emergency room staff to discharge the patient and that he would give her specific medications to go home with. He called in the medications, but they did not work. He gave her specific medication that did not work, half of her face was turning purple. The purple face was then replaced by an area approximately 1 inch wide on cheek between temple and the jaw. It was 1.5 inches long and was red and looked like a rash or welt. The patient would take an inhaler when she started to have breathing difficulties. That was when the reporter was like "here she goes again". It felt like it almost made her asthma worse and had to treat that as well. There was a little oddity when they did blood work on her daughter and her white blood count was high and was probably her body reacting to the COVID-19 vaccine. So, she went back to the hospital. The nurses said there was nothing they could do for her, and she needed to find an allergist. The reporter stated that she was tired of the ER visits and wanted her daughter to get better. She stated that she doubled the dose of her daughter's Tagamet. She stated that the patient's face and neck swells and she would get tachycardia. The reporter stated that she would not take her daughter to the hospital anymore. The hospital did not think it could be related to the vaccine, but she had not done anything else. The reporter wanted to report this event because she did not think people were taking this seriously. She stated that no one believed it was related to the vaccine, so they were not getting help. She wanted to know if this was a side effect and what could she do about it. She also inquired on whether her daughter should get the second shot. She stated that her daughter would not get the second shot. She had heard that if you had any reaction to the vaccine, then you should not receive the second dose. Her daughter's doctors have told her to receive the second vaccine. The reporter also stated that she wondered if this was some mast cell activation due to Ehlers-Danlos syndrome. The reporter also asked if Pizer made a preservative free vaccine. Upon follow-up received on 27Apr2021, the patient called to report that she was still experiencing side effects from the anaphylactic reaction and it had been 10 days since administration. She was told it would last about 4-10 days and then be gone, but it had continued, and it had been over 10 days. She had no new symptoms, other than a lot of bone pain. The bone pain made it feel like her bones were shattering. She went to the ER yesterday where they did blood work and said that all of her white blood cell counts were elevated. The anaphylaxis lasted from 17Apr2021 and subsided in that sense on 24Apr2021.  Since then she still had the chest pain, some trouble breathing, and felt like she was having an asthma attack. She had been back and forth to the ER several times since 17Apr2021. The ER kept ruling her symptoms as a reaction to the vaccine. She had been using epinephrine as needed. The patient stated that she was not planning on receiving the second dose due to her reaction. She wanted to know where she should go from here. She wanted to know if this would last forever and how much longer could her symptoms last. The clinical outcomes of the events ginormous welts/rash or welt 1.5 inches by 1 inch on cheek, itching in back of throat and a lot of bone pain were not recovered/not resolved; dark purple on face was recovered/resolved on 21Apr2021; outcomes of all other events were unknown.