Age: 35.0
Sex: F
Vaccine: RAB
Symptoms: Proctalgia, Pyrexia, Somnolence, Spleen disorder, Tinnitus
Clinical narrative: The 1st dose-5/2/01-Soon after the HDCV: urticaria appeared and 6 to 8 hours later my anus had begun to burn. 5/5/01-At night: fever (37.4C) and intense asthenia. 5/2-3/01-profound asthenia. No fever. 5/5/01-I was submitted to the 2nd dose of HDCV-6 to 8 hours later: my eyes, my throat and my gum had begun to burn ver hard. 5/9/01-The 3rd dose of HDCV-All my mucous membranes (eyes, throat, ears, anus, etc) burned very hard all day long. 5/9-16/01-Weakness in the upper and lower extremities, particularly walking or holding my baby. 5/16-17/01-Sporadic paresthesias in hands and arms. 5/19/01-Tingling paresthesias in both hands (gloves), intense, all day long. 5/20/01-Intense paresthesias in both hands (gloves) and feet (boot), all day long. 5/21/01-Besides the paresthesias in hands and feet, strange sensations like fasciculations all the body, mainly in legs. 5/22/01-My right toes ache during the shower, when the water touched them. 5/23-30/01-Strange sensations like: "Thunders", "Schocks", or "flashes" coming up from my toes to my thighs, intense, all day long. Worsening at evening and when I touched something. 6/1-5/01-The sensations like thunders coming up my toes to my thighs stopped. And the paresthesias reduced to my hands (palms) and my feet (soles). 6/7-14/01-The paresthesias increased (the paresthesias spread to thighs and buttock). My left hand burned all day long and I feel like something tightening my anus. 6/15/01-The paresthesias spread to my spinal cord (thorax). One night I woke up with a intense "thunder" or "flash" ascending my spinal thoracic cord. 6/22/01-Other night I woke up with a intense "thunder" or "flash" ascending my spinal cord (cervical). My both arms burning. Tinnitus twice. 7/01-Sporadic headache (I had never felt headache before in my life)-The headache was parietal and temporal, always at the left side. 10/01-Tongue and throat fasciculations (?). Annoying sensations during swallowing that goes to the ears. 11/01-Pain like "pinch" in arms, hands, legs and feet. Cramps mainly in legs. Piloerection in all body (sometimes in chest, sometimes in head, sometimes in hands, etc). 12/01-1/02-Intense paresthesias besides spinal cord (cervical, thoracic). Moderate headache just in the middle of the head and sometimes headache (temporal and parietal only at left side). 3/02-The sweat is reduced. Constipation. Sometimes somnolence. Sometime I forget what I would do. 5/02-Paresthesias and fasciculations. Pain like "inches" mainly in the arms and legs. Constipation? flatulence Reduced sweating. Somnolence Abdominal pain (left upper quadrant) Headache (just in the middle of the head, sometimes in parietal and temporal lobes) Sometimes forgetful. Treatment: Medications used to relieve these symptoms: 6/25/01 to 8/13/01-Amitripyline-25mg-twice a day; the paresthesias relieved, but the fasciculations increased. The physical exercise gets better. Stopped Amitriptyline due to urinary retention. 8/23/01 to 9/8/01-Gabapentin 300mg twice a day-The paresthesias and fasciculations decreased, but still remain. 10/16/01-Sertraline 50mg-once a day; alprazolam 0.5mg twice a day, and flunitrazepam 1mg at night to sleep. During the first month: the symptoms were under control. Soon after they returned. 4/02-Sertraline 50mg-once a day; alprazolam 0.5mg (at morning) and 0.25mg at night. Flunitrazepam-stopped. Paresthesias, fasciculations, pain, constipation and decreased sweat until today.