Age: 55.0
Sex: F
Vaccine: COVID19
Symptoms: Chromaturia, Diarrhoea, Feeling abnormal, Hepatic steatosis, Hepatomegaly
Clinical narrative: a mild anaphylactic reaction; the next day I woke with severe swelling throughout my body; along with joint pain; stiffness; the normal of not really feeling that great; seronegative rheumatoid arthritis; extreme abdominal pain; potassium level had dropped; my liver is enlarged and extremely fatty; my liver is enlarged and extremely fatty; pancreas is mildly atrophied; I also have been having diarrhea; dark urine since the day after getting the vaccine; This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP). The reporter is the patient.  A 55-year-old female patient (not pregnant) received BNT162b2 (BNT162B2), on 19Oct2021 at 11:30 as dose 1, single (Lot number: 30145BA) at the age of 55 years, in left arm for covid-19 immunisation. The patient's relevant medical history included: "Mild hypertension" (unspecified if ongoing); "stable Hashimoto's" (unspecified if ongoing); "L SI joint" (unspecified if ongoing); "low back strain" (unspecified if ongoing); "Known allergies: bee sting" (unspecified if ongoing); "Known allergies: CT dye injection" (unspecified if ongoing); "Known allergies: latex" (unspecified if ongoing); "Known allergies: sea urchin" (unspecified if ongoing); "Known allergies: clams" (unspecified if ongoing); "Known allergies: oysters" (unspecified if ongoing). Concomitant medication(s) included: BENADRYL; LOSARTAN; METOPROLOL; CYMBALTA; CLARITIN [LORATADINE]. Past drug history included: Known allergies: norco, reaction(s): "drug allergy"; Known allergies: provera, reaction(s): "drug allergy"; Known allergies: levaquin, reaction(s): "drug allergy"; Known allergies: nortriptyline, reaction(s): "drug allergy". No other vaccine was received on 19Oct2021, no other vaccine in four weeks. The following information was reported: DIARRHOEA (disability) with onset 2021, outcome "not recovered", described as "I also have been having diarrhea"; CHROMATURIA (disability) with onset 2021, outcome "not recovered", described as "dark urine since the day after getting the vaccine"; ABDOMINAL PAIN (disability) with onset 2021, outcome "not recovered", described as "extreme abdominal pain"; HEPATOMEGALY (disability), HEPATIC STEATOSIS (disability) all with onset 2021, outcome "not recovered" and all described as "my liver is enlarged and extremely fatty"; PANCREATIC ATROPHY (disability) with onset 2021, outcome "not recovered", described as "pancreas is mildly atrophied"; BLOOD POTASSIUM DECREASED (disability) with onset 2021, outcome "not recovered", described as "potassium level had dropped"; ANAPHYLACTIC REACTION (disability) with onset 19Oct2021 at 11:45, outcome "not recovered", described as "a mild anaphylactic reaction"; ARTHRALGIA (disability) with onset 19Oct2021 at 11:45, outcome "not recovered", described as "along with joint pain"; RHEUMATOID ARTHRITIS (disability) with onset 19Oct2021 at 11:45, outcome "not recovered", described as "seronegative rheumatoid arthritis"; MUSCULOSKELETAL STIFFNESS (disability) with onset 19Oct2021 at 11:45, outcome "not recovered", described as "stiffness"; SWELLING (disability) with onset 19Oct2021 at 11:45, outcome "not recovered", described as "the next day I woke with severe swelling throughout my body"; FEELING ABNORMAL (disability) with onset 19Oct2021 at 11:45, outcome "not recovered", described as "the normal of not really feeling that great". The events "a mild anaphylactic reaction", "the next day i woke with severe swelling throughout my body", "along with joint pain", "stiffness", "the normal of not really feeling that great", "seronegative rheumatoid arthritis", "extreme abdominal pain", "potassium level had dropped", "my liver is enlarged and extremely fatty", "pancreas is mildly atrophied", "i also have been having diarrhea" and "dark urine since the day after getting the vaccine" required physician office visit and emergency room visit. The patient underwent the following laboratory tests and procedures: SARS-CoV-2 test: (Sep2022) Negative, notes: Covid test post vaccination: Nasal Swab; Blood potassium: (2021) dropped, notes: 10 days prior to receiving the vaccine her potassium level was fine per lab work. Therapeutic measures were taken as a result of anaphylactic reaction, swelling, arthralgia, musculoskeletal stiffness, feeling abnormal, rheumatoid arthritis, abdominal pain, blood potassium decreased, hepatomegaly, hepatic steatosis, pancreatic atrophy, diarrhoea, chromaturia. Clinical course: 15 minutes after receiving the vaccine she had a mild anaphylactic reaction, it was mild because she was already on a Benadryl prep. The next day she woke with severe swelling throughout her body along with joint pain, stiffness and the normal of not really feeling that great. The joint pain and stiffness have remained now for almost a year and has caused seronegative rheumatoid arthritis as well as activated her what was stable Hashimoto's (her antibodies are five times higher). Also two weeks after receiving the vaccine she was in the emergency room with extreme abdominal pain, to which it was then discovered that her potassium level had dropped (10 days prior to receiving the vaccine her potassium level was fine per lab work) and her liver is enlarged and extremely fatty and her pancreas is mildly atrophied, where as she had never had any issues with liver or pancreas prior to. She also had been having diarrhea as well as dark urine since the day after getting the vaccine. Ae treatment Rheumatology included Prednisone and Methotrexate.