Sex: M
Vaccine: TYP
Symptoms: Lymphadenopathy, Peripheral swelling, Rash, Wheezing
Clinical narrative: UNABLE TO PALPATE A LYMPH NODE UNDER HIS ARMS, BUT IT WAS PRETTY SWOLLEN; LITTLE BIT OF WHEEZING BEFORE ARRIVAL; REMARKABLE RASH ALL OVER HIS WHOLE BODY / BOTH OF HIS ARMS HAD A DIFFERENT TYPE OF RASH AND WERE VERY ERYTHEMATOUS; HAD SHORTNESS OF BREATH, AND HE HAD SOME HEAVINESS; RED SKIN/ HIS ARMPITS WERE VERY RED/ HE HAD REDNESS ALL OVER HIS WHOLE BODY; UNDERSIDE OF BOTH OF HIS ARMS WERE EXTREMELY SWOLLEN; This spontaneous case report (PVX2019-2092) was received from a physician on 13-Aug-2019. It described a 48-year-old adult male consumer who had "red skin/ his armpits were very red/ he had redness all over his whole body" (PT: Generalised erythema), "underside of both of his arms were extremely swollen" (PT: local swelling), "remarkable rash all over his whole body / both of his arms had a different type of rash and were very erythematous" (PT: Rash), "unable to palpate a lymph node under his arms, but it was pretty swollen" (PT: Lymphadenopathy), "shortness of breath, and he had some heaviness" (PT: Dyspnoea), and "little bit of wheezing" (PT: Wheezing), after the administration of Vivotif for an unknown indication.  Case report: The consumer took the Vivotif doses on 08-Aug-2019, 10-Aug-219, and 12-Aug-2019, respectively. He reported that after administration of doses, he had allergic reactions. On 10-Aug-2019, after administration of second dose, he had red skin, underside of both of his arm were extremely swollen, his armpits were very red, and had redness all over his whole body along with shortness of breath, and some heaviness. Then, he took the third dose on 12-Aug-2019 after which the adverse events got worse.   On 13-Aug-2019, he had visited to urgent care and was prescribed him Benadryl (Diphenhydramine) for allergic reaction. At a time of visit, he had a remarkable rash all over his whole body. Both of his arms had a different type of rash and were very erythematous. It was reported that she was unable to palpate a lymph node under his arm, but it was swollen.  It was reported that his lungs were clear, but he had a little bit of wheezing before arrival, but there was no wheezing on exam. She stated that it was difficult to determine if the Benadryl helped the patient. Since it was given on 13-Aug-2019, there had not been much time for it to work.  The consumer had no medical history and no known drug allergies.  The past medication included hepatitis A and yellow fever vaccine, which was taken on 05-Aug-2019.  Action taken with Vivotif was unknown.  The clinical outcome of the events "red skin/ his armpits were very red/ he had redness all over his whole body" and "underside of both of his arms were extremely swollen" was not resolved, while the clinical outcome of the events "remarkable rash all over his whole body / both of his arms had a different type of rash and were very erythematous", "unable to palpate a lymph node under his arms, but it was pretty swollen", "shortness of breath, and he had some heaviness", and "little bit of wheezing before arrival" was unknown.  The reporter considered the reported events was related to vaccine.  Company's Comment: In this case, it was reported that the consumer had "red skin/ his armpits were very red/ he had redness all over his whole body", "underside of both of his arms were extremely swollen", "remarkable rash all over his whole body / both of his arms had a different type of rash and were very erythematous", "unable to palpate a lymph node under his arms, but it was pretty swollen", "shortness of breath, and he had some heaviness", and "little bit of wheezing" following administration of Vivotif. There is a significant temporal association between the intake of the vaccine and the events. Also, the events got worse after the intake of third dose. Hence, the causality of the events with Vivotif is assessed as possible.; Sender's Comments: Company's Comment: In this case, it was reported that the consumer had "red skin/ his armpits were very red/ he had redness all over his whole body", "underside of both of his arms were extremely swollen", "remarkable rash all over his whole body / both of his arms had a different type of rash and were very erythematous", "unable to palpate a lymph node under his arms, but it was pretty swollen", "shortness of breath, and he had some heaviness", and "little bit of wheezing" following administration of Vivotif. There is a significant temporal association between the intake of the vaccine and the events. Also, the events got worse after the intake of third dose. Hence, the causality of the events with Vivotif is assessed as possible.