Sex: U
Vaccine: RVX
Symptoms: Death, Diarrhoea, Human bocavirus infection, Rotavirus test positive
Clinical narrative: This case was reported in a literature article and described the occurrence of human bocavirus infection in a infant subject who received Rotavirus vaccine for prophylaxis. Concurrent medical conditions included ipex syndrome (Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome). On an unknown date, unknown after receiving Rotavirus vaccine, the subject developed human bocavirus infection. Serious criteria included death and hospitalization. Additional event(s) included diarrhea with serious criteria of hospitalization. The outcome of human bocavirus infection was fatal. The outcome(s) of the additional event(s) included diarrhea (unknown). The reported cause of death was human bocavirus infection. The investigator considered that there was a reasonable possibility that the human bocavirus infection and diarrhea may have been caused by Rotavirus vaccine. Relevant Tests: Lab tests were performed on unspecified date between Feb 2006 to Dec 2015. Patient's stool sample tested for detection of rotavirus. Patient was found positive for rotavirus vaccine strain. Diagnostic results (unless otherwise stated, normal values were not provided):  On an unknown date, Stool analysis result was see text. Additional information was provided. This case was reported in a literature article and described the occurrence diarrhea and human bocavirus infection of in an infant of unspecified age and gender who was vaccinated with unspecified rotavirus vaccine (manufacturer unknown) for prophylaxis. This case corresponds to table 1 reported in this literature article. The patient was part of the study that characterize adverse events (AE) after rotavirus (RV) in infants with immunocompromising conditions (IC) reported to the Vaccine Adverse Event Reporting System (VAERS) from February 2006 to December 2015. The patient had Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome. No information on patient's medical or family history or concomitant medication were provided. On an unspecified date, the patient received unspecified rotavirus virus vaccine (administration route and site unspecified, dosage unknown; batch number not provided). The age of vaccination was not provided. On an unspecified date, an unknown period after vaccination, the patient developed diarrhea and subsequently, hospitalised. Patient's stool sample tested for detection of rotavirus. Patient was found positive for rotavirus vaccine strain. On an unspecified date, the patient died due to human bocavirus infection. It was unknown if an autopsy was performed. This case has been considered as serious due to death/hospitalisation. The treatment was unknown. The author stated and concluded, "Adverse event (AE) after RV in immunocompromised infants are rarely reported to VAERS, but most are clinically serious events. Additional data would be helpful in assessing the safety of RV in non-SCID IC including in-utero exposure to monoclonal antibodies MAB" This is 1 of the 11 valid cases reported in this literature article. Lab Comments: Lab tests were performed on unspecified date between Feb 2006 to Dec 2015. Patient's stool sample tested for detection of rotavirus. Patient was found positive for rotavirus vaccine strain.; Reported Cause(s) of Death: Human bocavirus infection.