Age: 51.0
Sex: F
Vaccine: COVID19, COVID19
Symptoms: Immediate post-injection reaction, Rash, Swollen tongue, Tachycardia
Clinical narrative: High blood pressure; Tachycardia; Got really weak; Facial Edema; Very rapid breathing; Face was Flushed and red; Face was Flushed and red; she felt hot; Flushing; Swelling; Fast Heart Rate 150-160; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP) from medical information team for a Pfizer sponsored program (159558). The reporter is the patient.  A 51 year-old female patient received bnt162b2 (COMIRNATY), administered in arm, administration date 22Mar2021 14:00 (Lot number: EN6207, Expiration Date: 31Jul2021) at the age of 51 years as dose 1, single for covid-19 immunisation. Relevant medical history included: "Celiac disease" (unspecified if ongoing), notes: She has Celiac diagnosed 10 years ago, 2010-2011; "Migraine", start date: 2008 (unspecified if ongoing), notes: She had Migraines diagnosed 2008, she was on Topamax for migraines; She does not have a lot or expiration for Topamax. She went off of Topamax in 2017 or 2018; "obese" (unspecified if ongoing), notes: She is borderline obese and has perfect triglycerides and blood sugar; "Postural orthostatic tachycardia" (unspecified if ongoing), notes: She has a history of autonomic problems like Postural orthostatic tachycardia.; "sleep apnea" (unspecified if ongoing), notes: She has sleep apnea and was prescribed Modafinil, had heard it could raise heart rate and blood pressure, but she has not experienced that.; "carnitine deficiency" (unspecified if ongoing), notes: She also takes Carnitine for carnitine deficiency; "exercised" (unspecified if ongoing), notes: she had exercised very hard  before the vaccination. Family history included: "heart failure" (unspecified if ongoing), notes: Father died of heart failure; "diabetic" (unspecified if ongoing), notes: All 4 grandparents and both parents are diabetic; "autoimmune myositis" (unspecified if ongoing), notes: Dad had autoimmune myositis; "kidney failure" (unspecified if ongoing), notes: Mom has kidney failure, lymphoma and breast cancer; "lymphoma" (unspecified if ongoing), notes: Mom has kidney failure, lymphoma and breast cancer; "breast cancer" (unspecified if ongoing), notes: Mom has kidney failure, lymphoma and breast cancer. There were no concomitant medications. The following information was reported: HYPERTENSION (non-serious) with onset 22Mar2021, outcome "unknown", described as "High blood pressure"; FLUSHING (non-serious) with onset 2021, outcome "unknown", described as "Flushing"; SWELLING (non-serious) with onset 2021, outcome "unknown", described as "Swelling"; HEART RATE INCREASED (non-serious) with onset 2021, outcome "unknown", described as "Fast Heart Rate 150-160"; TACHYCARDIA (non-serious) with onset 22Mar2021, outcome "unknown", described as "Tachycardia"; ASTHENIA (non-serious) with onset 22Mar2021, outcome "recovering", described as "Got really weak"; FACE OEDEMA (non-serious) with onset 22Mar2021, outcome "recovering", described as "Facial Edema"; RESPIRATORY RATE INCREASED (non-serious) with onset 22Mar2021, outcome "unknown", described as "Very rapid breathing"; FLUSHING (non-serious), ERYTHEMA (non-serious) all with onset 22Mar2021, outcome "recovering" and all described as "Face was Flushed and red"; FEELING HOT (non-serious) with onset 22Mar2021, outcome "unknown", described as "she felt hot". The events "high blood pressure", "flushing", "swelling", "fast heart rate 150-160", "tachycardia", "got really weak", "facial edema", "very rapid breathing", "face was flushed and red", "face was flushed and red" and "she felt hot" were evaluated at the physician office visit and emergency room visit. Relevant laboratory tests and procedures are available in the appropriate section. Therapeutic measures were taken as a result of hypertension, flushing, heart rate increased, tachycardia, asthenia, face oedema, respiratory rate increased, flushing, erythema, feeling hot.  Additional information: Father died of heart failure. All 4 grandparents and both parents are diabetic. Dad had autoimmune myositis. Mom has kidney failure, lymphoma and breast cancer.    Patient detailed her whole day, what Patient ate, and everything just in case there was some contextual information or whatever. Patient has a history of autonomic problems like Postural orthostatic tachycardia. Patient gets these attacks periodically, like Patient was on Topamax for migraines and it would sometimes cause that. Patient's not allergic to anything. Patient has not taken it in years. Patient does not have a lot or expiration for Topamax. Patient went off of Topamax in 2017 or 2018. Patient was a librarian in a healthcare consulting firm. Patient thinks was 189 pounds at the time of the vaccine, Patient thinks she is currently 195 pounds. Patient is in the process of getting a new primary care. Patient does not have a complete address, phone or email for them. Patient knew immediately that something was not right. As soon as the shot went in, she felt hot and then they had them walk to observation room. Patient felt like she was walking a mile. It was a standard hallway and she felt it was forever. Patient got really weak and plopped down in first chair she could find. Regarding the Tachycardia, she was sitting in first chair and the lady observer was handing out literature and she looked at her and asked her if she was feeling ok. Patient said not really, she was blood red and flushed. The tachycardia lasted in total 3 days. Patient had another attack of tachycardia in Jun2021 It resolved 27Mar2021, and showed it's head again in Jun2021. Patient had to go to the ER and has not had an attack since then. Caller states the tachycardia improved. Hypertension persisted for the same amount of time and then went away and went back to baseline. Facial Edema was more in her tongue and fingers. Patient had sausage fingers. It was like flash edema. They called the medic and they put her on a gurney and took vitals. Patient had extreme rapid breathing. It was pretty high and she does not know the number. They tried the Valsalva to get her breathing down and it did not work. Kept for 12 hours approximately and released. They gave her mostly IV fluid, saline. The paramedics were ready to push EpiPen, and because her blood pressure was so high, she did not want it. The EPI would have given her a stroke, she feared. She said this is not a anaphylactic response. They wanted to push antihistamine in the ER, and she refused that. It was just a neuro cardiac response she felt.  Patient was discharged at midnight and admitted at 3pm. It was around 12 hours. Patient talked it to her doctor and he said it could have been stress or anxiety and she said she knows what a panic attack feels like and this was not it. When she has an anxious reaction or intense, she is able to breathe through it and get rid of sweaty palms. It is also worth mentioning, she had exercised very hard before the vaccination. Patient had heard that you are laid up after the vaccine and knew that she would be fatigued. Patient could have been loaded with histamines before that and should have been hydrated and rested for the shot. 2nd dose Pfizer COVID 19 vaccine was given on 27Nov2021, Lot FJ1611, Expiration 31May2022, Injected in right arm. Patient has sleep apnea and was prescribed Modafinil, had heard it could raise heart rate rate and blood pressure, but Patient has not experienced that. Patient was not taking it, it was just prescribed. Patient also takes Carnitine for carnitine deficiency. Both were diagnosed prior. No further details provided. the patient took 2nd dose of Pfizer COVID 19 vaccine Lot Number/Expiry Date: Lot FJ1611, Expiration 31May2022 on right arm. She had primary care visit and advised allergy testing. She consulted with her first and said not to get second dose until she had allergy test and she saw allergist/immunologist and she tested for polyethylene glycol, polysorbate and both of those were negative. She saw her cardiologist. She did an ECG and it had some artifacts on it. One was possible left atrial enlargement. She thinks the enlargement was there before. The second artifact could not rule out prior infarction and she said that was new. Otherwise, it was a normal ECG with sinus rhythm. Patient did not have any prior vaccinations within 4 weeks.   Follow-up attempts completed. No further information expected.