Age: 0.18
Sex: F
Vaccine: DTAP, HBHEPB, IPV, PNC, RV5, DTAP, HBHEPB, IPV, PNC, RV5, DTAP, HBHEPB, IPV, PNC, RV5
Symptoms: Pyrexia, Red blood cells urine positive, Respiratory arrest, Specific gravity urine increased, Unresponsive to stimuli
Clinical narrative: Information has been received from a physician concerning a 9 week old female, with no medical history and no allergies, who on 27-Dec-2006 was vaccinated with a second oral dose of Rotateq vaccine (human-bovine) (Lot#655406/1114F). Concomitant vaccines administered on the same day included a second IM dose in the left leg of HIB conj-hepatitis B vaccine (Lot#654908/0999F), a second intramuscular dose in the left leg of Prevnar (lot#858849D), a second SQ dose in the right leg of IPOL (lot#41031) and a second IM dose in the right leg of Infanrix (LOT#AC14B14215A). It was reported that the patient developed a mild upper respiratory infection with a cough on 25-Dec-2006. The patient had been given Tylenol after the vaccinations. On the evening of 27-Dec-2006, at around 2:30 the patient was noted to have some difficulty breathing with increased work of breathing, and subsequently vomited one time with a mucousy/phlegm appearance. The patient then stopped breathing for about two minutes, went limp, and was noted to have significant pallor. The emergency number was called. During that two minutes, the patient had a period where she was not responding and had decreased tone. There was no seizure-like activity noted. She subsequently was aroused and her color returned to normal. She was brought to the emergency room via ambulance. She did not require any treatments or oxygen during her transport. The patient's mother reported that the patient had nasal congestion and decreased PO secondary to the nasal congestion. She also had a decreased amount of wet diapers, about 3-4 times on 28-Dec-2006, with the last being around 2:00 am. The patient had sick contacts. Her sibling had upper respiratory infection symptoms. It was noted that she had never had a similar episode in the past. A complete review of systems was obtained. The patient was positive for fever, vomiting (one time), nasal congestion, cough, and a period of apnea. The patient was negative for diarrhea, rash, and seizure activity. All other systems were otherwise negative. The differential diagnosis of the acute life-threatening event episode included bronchiolitis with apneic episode possibly secondary to a mucous plug versus central apnea versus other infectious cause versus possible cardiac cause versus reflux versus other infectious cause versus possibly secondary to a mucous plug versus other respiratory cause and seizure much less likely given no history of seizure type activity. A work-up was done that included a complete blood cell count with differential, blood culture, basal metabolic panel, urinalysis, and urine culture and chest x-ray was done. It was reported that given that the episode was likely secondary to bronchiolitis a lumbar puncture was deemed necessary at that point. A complete blood cell count was done that showed a normal white count with white blood cells of 11.6, hemoglobin of 9.6, hematocrit of 29.2, platelets of 448 with a differential of 59 polys, 3 bands, 28 lymphs, 9 mono, and 1 eosinophil. The basal metabolic panel was notable for slightly elevated glucose at 157, and was otherwise normal with a sodium of 138, potassium of 5.1, chloride of 104, bicarbonate of 24, blood urea nitrogen of 6, creatinine of 0.2, and calcium of 9.9. A urinalysis was done that showed a specific gravity of 1.026, 1+ protein, negative for glucose, negative for ketones, negative for nitrates, negative for leukocyte esterase, 20 red blood cells, 25 white blood cells, and moderate bacteria. A chest x-ray was done that showed a slightly increased streaking bilaterally, no focal infiltrates, as well as hyperinflation with slightly flattened diaphragms bilaterally. The decision was made at that point, on 28-Dec-2006, to admit the patient for bronchiolitis with an apneic episode and an apparent life-threatening event. The patient was transferred to the medical unit and required suctioning, however was relatively un-tachypneic throughout the hospitalization and was able to feed well. On the day of discharge, on 29-Dec-2006, the patient had not required suction for more than 12 hours and was feeding well. The discharge diagnosis was an acute life threatening event, bronchiolitis, and fever. The discharge plan was to continue bulb suctioning at home as needed, to follow-up with the primary care physician in three days or earlier is symptoms worsened, or to the emergency room if there was trouble breathing. The patient was reported as recovered as 29-Dec-2006. Acute life threatening event was considered to be an immediately life threatening event. A lot check has been requested. Additional information is not expected.