Age: 18.0
Sex: M
Vaccine: HPV4, MEN
Symptoms: Arthralgia, Deafness, Ear infection, Ear pain, Electroencephalogram
Clinical narrative: Information has been received from a female consumer referring to her son, a 18 year old male patient with scoliosis at a 16 degree angle. On 27-NOV-2012, the patient was vaccinated with the first dose of GARDASIL injection (lot # K004205) 0.5 ml (expiration date and route were not available) injection in the arm. After the first dose there was no adverse event. On 13-OCT-2014, the patient was vaccinated with the second dose of GARDASIL injection (lot # K004205) (incorrect schedule of vaccine administration). The patient also received a meningococcal vaccine (unspecified) concomitantly with the GARDASIL and a influenza virus vaccine (unspecified) on 16-OCT-2014 (incorrect schedule of vaccine administration). On an unknown date in 2014 (reported as "within a few weeks" after receiving the second dose), the patient started experiencing joint and muscle pain. The patient also got sick and started running a fever. When the patient wasn't getting better, the patient's mother brought him to the doctor on 18-NOV-2014 and he was given an ZITHROMAX Z-PAK. The fever went away, but when the patient finished the ZITHROMAX Z-PAK, the fever came back and he had ear pain and couldn't hear. The doctor determined this to be an ear infection and prescribed another ZITHROMAX Z-PAK. On an unknown date in November 2014, the patient's doctor was concerned about his lymph nodes so the patient was sent to a head and neck surgeon who did x-rays but didn't see anything that concerned him. The patient had been occasionally experiencing the following additional adverse events that began at unspecified time periods after the second shot: "abnormal sensations" (burning sensation in the skin, numbness in the arms, tingling, a "wet sensation" and headaches), a rash in his armpits that lasted a few months and weight loss (the patient was presently 6 feet tall and weighed 108 pounds). On 03-FEB-2015, the patient was vaccinated with the third dose of GARDASIL injection (lot # K006960) (incorrect schedule of vaccine administration). After the third shot, the patient started to need a cane to walk. On 14-FEB-2015 the doctor referred the patient to a rheumatologist who was "totally stumped" and who referred him to a geneticist who had "no idea" what it could be. The doctor then referred him to a neurologist who did an electroencephalogram (EEG) and detected neuropathy in his legs. The neurologist did a spinal tap in October or November of 2015 and he saw inflammation of the cerebral B cells which could have been related to an inflammation of the immune system. The neurologist thought it could be cancer so he referred the patient to a hematologist/oncologist who determined that it wasn't cancer, but there were "markers from the spinal tap", but the yields weren't high. The doctor also referred the patient to an acupuncturist who referred him to a physical therapist, but the physical therapist didn't want to start any therapy until it could be determined what the problem was to be sure that he didn't do anything that could worsen the patient's condition. On an unknown date in February 2016 (reported as "last week"), the patient visited another neurologist who stated that the all this occurred because he wasn't exercising. The patient had also been to gastroenterologist and a nutritionist. The patient had also had to quit his job because he was no longer physically able to do it. The patient received nortriptyline, nabumetone, cyclobenzaprine hydrochloride, anti-inflammatory supplements and acupuncture as treatment. At the time of the report, the patient did not recover from the events. Upon internal review, the events of ear infection and inflammation of the cerebral B cells were considered to be medically significant. Additional information has been requested.