Age: 32.0
Sex: F
Vaccine: COVID19
Symptoms: Dyspnoea, Echocardiogram, Electrocardiogram, Exercise tolerance decreased, Gait disturbance
Clinical narrative: Peripheral neuropathy; Developed shortness of breath; a squeezing/tightness in the chest; Substantial exercise intolerance; cannot tolerate walking; Severe injection site and left arm pain; Severe injection site and left arm pain; Pain spread to the armpit, left breast,and chest; Pain spread to the armpit, left breast,and chest; Pain spread to the armpit, left breast,and chest; Fever of 101.9; pins and needles in the feet; burning calves; abdominal pain; lightheadedness; orthostatic tachycardia; This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP).  A 32-year-old female patient (not pregnant) received bnt162b2 (BNT162B2), intramuscular, administered in arm left, administration date 15Dec2021 (Lot number: FD7218) at the age of 32 years as dose 3 (booster), single for covid-19 immunisation. Relevant medical history included: "Acid reflux" (unspecified if ongoing); "Gall bladder removal" (unspecified if ongoing); "Endometriosis" (unspecified if ongoing); "Medication: Plan B pill" (unspecified if ongoing). There were no concomitant medications. Vaccination history included: Bnt162b2 (DOSE 1, SINGLE, Batch/Lot No: EL1283, Location of injection: Arm Left, Route of Administration: Intramuscular), administration date: 2021, for COVID-19 Immunization; Bnt162b2 (DOSE 2, SINGLE, Batch/Lot No: EN5318, Location of injection: Arm Left, Route of Administration: Intramuscular), administration date: 2021, for COVID-19 Immunization. The following information was reported: PARAESTHESIA (disability), outcome "unknown", described as "pins and needles in the feet"; BURNING SENSATION (disability), outcome "unknown", described as "burning calves"; ABDOMINAL PAIN (disability), outcome "unknown", described as "abdominal pain"; DIZZINESS (disability), outcome "unknown", described as "lightheadedness"; TACHYCARDIA (disability), outcome "not recovered", described as "orthostatic tachycardia"; VACCINATION SITE PAIN (hospitalization, disability) with onset Dec2021, outcome "unknown", PAIN IN EXTREMITY (hospitalization, disability) with onset Dec2021, outcome "not recovered" and all described as "Severe injection site and left arm pain"; NEUROPATHY PERIPHERAL (hospitalization, disability, medically significant) with onset 16Dec2021 08:00, outcome "not recovered", described as "Peripheral neuropathy"; AXILLARY PAIN (hospitalization, disability), BREAST PAIN (hospitalization, disability), CHEST PAIN (hospitalization, disability) all with onset Dec2021, outcome "not recovered" and all described as "Pain spread to the armpit, left breast, and chest"; PYREXIA (hospitalization, disability) with onset Dec2021, outcome "recovered" (Dec2021), described as "Fever of 101.9"; DYSPNOEA (hospitalization, disability) with onset 16Dec2021 08:00, outcome "unknown", described as "Developed shortness of breath"; CHEST DISCOMFORT (hospitalization, disability) with onset 16Dec2021 08:00, outcome "unknown", described as "a squeezing/tightness in the chest"; EXERCISE TOLERANCE DECREASED (hospitalization, disability) with onset 16Dec2021 08:00, outcome "unknown", described as "Substantial exercise intolerance"; GAIT DISTURBANCE (hospitalization, disability) with onset 16Dec2021 08:00, outcome "unknown", described as "cannot tolerate walking". The patient was hospitalized for vaccination site pain, pain in extremity, neuropathy peripheral, axillary pain, breast pain, pyrexia, dyspnoea, chest discomfort, exercise tolerance decreased, gait disturbance (start date: 20Dec2021, discharge date: 20Dec2021, hospitalization duration: 1 day(s)); for chest pain (start date: 20Dec2021, discharge date: Dec2021, hospitalization duration: 1 day(s)). The events "pins and needles in the feet", "burning calves", "abdominal pain", "lightheadedness", "orthostatic tachycardia", "severe injection site and left arm pain", "severe injection site and left arm pain", "peripheral neuropathy", "pain spread to the armpit, left breast, and chest", "pain spread to the armpit, left breast, and chest", "pain spread to the armpit, left breast, and chest", "fever of 101.9", "developed shortness of breath", "a squeezing/tightness in the chest", "substantial exercise intolerance" and "cannot tolerate walking" were evaluated at the physician office visit and emergency room visit. The patient underwent the following laboratory tests and procedures: blood test: (Dec2021) unknown results; body temperature: (Dec2021) 101.9; cardiac monitoring: (Dec2021) unknown results; echocardiogram: (Dec2021) unknown results; electrocardiogram: (Dec2021) unknown results; heart rate: (Dec2021) 120-130, notes: bpm, upon standing; troponin: (Dec2021) unknown results. Therapeutic measures were taken as a result of chest pain, dyspnoea. The patient had not received any other vaccines within 4 weeks prior to the COVID vaccine. There were no list of any other medications the patient received within 2 weeks of vaccination. The patient experienced severe injection site and left arm pain 12 hours post vaccination.  Pain spread to the armpit, left breast, and chest by 24 hours post vaccination. The patient experienced fever of 101.9 at 24 hours post vaccination, and fever lasted about 6 hours. Chest pain increased in severity as arm, armpit, and breast pain decreased.  First Emergency room (ER) visit on 17Dec2021 with complaints of chest pain.  The patient developed shortness of breath and a squeezing/tightness in the chest in addition to sharp chest pain. The patient was admitted to the hospital on 20Dec2021 for observation. The patient developed additional symptoms following release from the hospital, including orthostatic tachycardia (120-130 bpm upon standing), lightheadedness, burning calves, abdominal pain, and pins and needles in the feet.  Chest pain and shortness of breath were controlled with colchicine 0.6 mg 2x/day and bed rest but return within hours of the medication wearing off.  Peripheral neuropathy and orthostatic tachycardia persist. The patient experienced substantial exercise intolerance and could not tolerate walking etc. Prior to vaccination, the patient was not diagnosed as COVID-19. Since the vaccination, the patient had not been tested for COVID-19.   No follow-up attempts are needed. No further information is expected.