Age: 24.0
Sex: F
Vaccine: COVID19
Symptoms: Urticaria
Clinical narrative: she never had problem till covid shot and each time it got worse/rash were worse; it is eczema but never had problems till covid shot caused me to itch mostly daily.; causes me pain from bruising myself; bruising myself and making purple small dots on me from itching; By the 3rd dose in April 2022 the wheals and rash were worse; By the 3rd dose in April 2022 the wheals and rash were worse; This spontaneous case was reported by a patient and describes the occurrence of CONDITION AGGRAVATED (she never had problem till covid shot and each time it got worse/rash were worse), ECZEMA (it is eczema but never had problems till covid shot caused me to itch mostly daily.), PAIN (causes me pain from bruising myself), CONTUSION (bruising myself and making purple small dots on me from itching) and RASH (By the 3rd dose in April 2022 the wheals and rash were worse) in an adult female patient who received mRNA-1273 (Spikevax) (batch no. 046C21A) for COVID-19 prophylaxis. The occurrence of additional non-serious events is detailed below.     Concurrent medical conditions included Itch, Pneumocystis pneumonia, Interstitial plasma cell pneumonia and Pneumocystis jiroveci pneumonia.   On 24-Mar-2022, the patient received third dose of mRNA-1273 (Spikevax) (Intramuscular use) 1 dosage form. In April 2022, received fourth dose of mRNA-1273 (Spikevax) (Intramuscular use) dosage was changed to 1 dosage form. On an unknown date, the patient experienced CONDITION AGGRAVATED (she never had problem till covid shot and each time it got worse/rash were worse), ECZEMA (it is eczema but never had problems till covid shot caused me to itch mostly daily.), PAIN (causes me pain from bruising myself), CONTUSION (bruising myself and making purple small dots on me from itching), RASH (By the 3rd dose in April 2022 the wheals and rash were worse) and URTICARIA (By the 3rd dose in April 2022 the wheals and rash were worse). The patient was treated with Cetirizine hydrochloride (Zyrtec) at an unspecified dose and frequency; Loratadine (Claritin) at a dose of UNK UNK, qd; Fexofenadine hydrochloride (Allegra) (oral use) at a dose of UNK, qd; Diphenhydramine hydrochloride (Benadryl) at an unspecified dose and frequency and Clotrimazole (Itch) at a dose of UNK, qd. At the time of the report, CONDITION AGGRAVATED (she never had problem till covid shot and each time it got worse/rash were worse), ECZEMA (it is eczema but never had problems till covid shot caused me to itch mostly daily.), PAIN (causes me pain from bruising myself), CONTUSION (bruising myself and making purple small dots on me from itching), RASH (By the 3rd dose in April 2022 the wheals and rash were worse) and URTICARIA (By the 3rd dose in April 2022 the wheals and rash were worse) outcome was unknown.        For mRNA-1273 (Spikevax) (Intramuscular use), the reporter did not provide any causality assessments.   No concomitant medication was reported.  It was prescribed some medication as well. Tried and still using itch creams over the counter and by daily. Was told by allergist that it would eventually work its way out of body and nothing can be done for unless my throat was closing up or  couldn't breathe and was having a "more urgent" issue pretty much. Dermatologist unable to relieved symptoms with oral antihistamines or topicals. Started off April 2021 with hives/rash and red all over and itchy but went away. Went for 2nd dose May of 2021 wheals got worse and more redness on skin and itchy lasting longer. By the 3rd dose in April 2022 the wheals and rash were worse and was told it would go away by allergist over time but it never fully went away and been itching in agony with a rash, could not always see eventually. Still itching and developed by 2023 still itching on and off till October-November 2023 a rash that then temporarily gave patient short on and off relief till it turned into what she thought was dry skin at her lower legs then went onto thighs, arm, nipples, mouth. Dermatologist thinks it was eczema but never had problems till covid shot caused her to itch mostly daily. One Topical given helped with getting rid of red around mouth and the worse of the plaque like skin growth on lip and body but it's still very itchy and won't go away fully so tried other topicals and with use of oral medication as well but it was not seem to go away and find herself itching every day since she started receiving the Covid shot but never has reactions directly after the shot would develop later by end of day after shot or within a day. Can't stop itching which was causing her to badly bruise her legs and scratch till she rip her skin open and bleed then end up itching of scabs because the area still remains itchy which made it harder to heal and caused her pain from bruising herself and making purple small dots on her from itching and breaking capillaries or vessels.   Patient had Skin gets flakey and builds a plaque and rash that cannot always be seen. her lips peels and no lotion, topical or chapstick can permanently cure it so far. she still now and that get a raised red wheal or rash like appearance on the which are red and become itchy. The itching keeps her from sleeping properly and getting through each day was difficult because she constantly find herself itching. she never had problem till covid shot and each time it got worse. she only received the shots because her job claimed to require and worked in healthcare and going to school for healthcare. She was tired of feeling miserable and hurting myself unintentionally and feel embarrassed by it. It was unknown if the patient experienced any additional symptoms/events. This case was linked to US-MODERNATX, INC.-MOD-2024-776069 (E2B Linked Report).; Sender's Comments:  US-MODERNATX, INC.-MOD-2024-776069:Same patient with different product