Sex: F
Vaccine: COVID19
Symptoms: Autoantibody test, C-reactive protein, Full blood count, Magnetic resonance imaging head, Red blood cell sedimentation rate
Clinical narrative: TRANSIENT THROMBOCYTOPENIA WITH GLYCOPROTEIN SPECIFIC PLATELET AUTOANTIBODIES; DENTAL PAIN; This spontaneous report was received from literature. This report concerned a 71 year old female. The patient's height, and weight were not reported. The patient's past medical history included: polymyalgia rheumatica, and acute right ear infection, and other pre-existing medical conditions included: The heparinplatelet factor 4 antibody enzyme-linked immunosorbent assay, both of which had unremarkable findings (the assay optical density was 0.057; reference, <0.400). The patient was previously treated with prednisone for polymyalgia rheumatica. The patient received covid-19 vaccine ad26.cov2.s (suspension for injection, route of admin not reported, batch number: Unknown, expiry: unknown ) one total dose, start therapy date were not reported for prophylactic vaccination. The batch number not reported has been requested. No concomitant medications were reported.  The 35 days after vaccination she developed headaches in the left temporal region, prompting evaluation by her rheumatologist for possible giant cell arteritis given her history of polymyalgia rheumatica. She did not report recurrence of polymyalgia rheumatic symptoms, and giant cell arteritis. The patient's headaches were ultimately attributed to referred dental pain due to occlusal trauma from a temporary dental bridge, and they resolved after dental intervention. The patient results were positive for platelet autoantibodies directed against all 3 glycoproteins at optical densities (transient thrombocytopenia with glycoprotein specific platelet autoantibodies). Laboratory data (dates unspecified) included: Autoantibody test (NR: not provided) Positive (units unspecified), negative, C-reactive protein (NR: not provided) 1.0 mg/L, Complete blood count (NR: not provided) Not reported, Erythrocyte sedimentation rate (NR: 0 - 22) 8 mm/h, Nuclear magnetic resonance angiography brain (NR: not provided) unremarkable findings, and Platelet count (NR: not provided) 143 X 10 9 cells/L, 429 x109 cells/L, 96 X 10 9 cells/L, 76 X 10 9 cells/L, 248 X 10 9 cells/L, 67 X 10 9 cells/L, 56 X 10 9 cells/L, 115 x 10 9 cells/L, 55 to 110 X 10 9 cells/L, 59 X 10 9 cells/L. The action taken with covid-19 vaccine ad26.cov2.s was not applicable. The patient recovered from dental pain, and was recovering from transient thrombocytopenia with glycoprotein specific platelet autoantibodies. This report was serious (Other Medically Important Condition).  The author emphasized if antiviral spike protein antibodies cross-reactive with platelet glycoproteins resulted in this clinical presentation, thrombocytopenia due to this mechanism could occur with other SARS-CoV-2 vaccines.; Sender's Comments: V0;20210929329-covid-19 vaccine ad26.cov2. s-Thrombocytopenia with glycoprotein specific platelet autoantibodies. This event is considered unassessable. The event has a compatible/suggestive temporal relationship, is unlabeled, and has unknown scientific plausibility. There is no information on any other factors potentially associated with the event.