Sex: F
Vaccine: COVID19, UNK
Symptoms: Rheumatoid arthritis
Clinical narrative: rheumatoid arthritis minor flared; rheumatoid arthritis flare up; This is a solicited report received from contactable reporter(s) (Consumer or other non HCP). The reporter is the patient. Other Case identifier(s): 22K-163-4385706-00.  A 37-year-old female patient received BNT162b2 (BNT162B2), as dose number unknown (booster), single (Batch/Lot number: unknown) intramuscular for covid-19 immunisation; upadacitinib (RINVOQ), (Batch/Lot number: unknown), oral for rheumatoid arthritis. The patient's relevant medical history and concomitant medications were not reported. Vaccination history included: Covid-19 vaccine (Primary Immunization series complete; MANUFACTURER UNKNOWN), for Covid-19 immunization. The following information was reported: RHEUMATOID ARTHRITIS (medically significant), outcome "recovering", described as "rheumatoid arthritis minor flared"; RHEUMATOID ARTHRITIS (medically significant), outcome "recovered", described as "rheumatoid arthritis flare up". The action taken for upadacitinib was unknown. The reporter considered "rheumatoid arthritis flare up" related to BNT162b2.   Clinical course: The events were non-serious Rheumatoid arthritis minor flared and Rheumatoid arthritis flare up with Rinvoq (Upadacitinib). There was no reported medical history. On unknown dates, the patient experienced Rheumatoid arthritis minor flared and Rheumatoid arthritis flare up. On unknown date, Rheumatoid arthritis flare up and covid booster was worse/patient was completely down resolved. Pfizer BioNTech Covid-19 Vaccine (Tozinameran) was also considered suspect. The patient had minor Rheumatoid arthritis flare and also she had rheumatoid arthritis flare up after received covid vaccination. It was unknown if patient was enrolled in a COVID-19 Vaccine trial.   Causality for Rinvoq (Upadacitinib): The reporter's causality for the event(s) of Rheumatoid arthritis minor flared and Rheumatoid arthritis flare up with RINVOQ (UPADACITINIB) was no reasonable possibility. Causality for Pfizer BioNTech covid-19 vaccine (Tozinameran): The reporter's causality for the event(s) rheumatoid arthritis minor flared (Rheumatoid arthritis flare up, Rheumatoid arthritis) was not reported. Causality for Pfizer BioNTech covid-19 vaccine (Tozinameran): The reporter's causality for the event(s) Rheumatoid arthritis flare up (Rheumatoid arthritis) was reported as possible.    No follow-up attempts are possible; information about lot/batch number cannot be obtained. No further information is expected.; Sender's Comments: Based on the known safety profile of the vaccine  BNT162b2, a causal relation between the reported events  Rheumatoid arthritis minor flared and Rheumatoid arthritis flare up and the administration of the vaccine cannot be excluded. The impact of this report on the benefit/risk profile of the Pfizer product is evaluated as part of Pfizer procedures for safety evaluation, including the review and analysis of aggregate data for adverse events. Any safety concern identified as part of this review, as well as any appropriate action in response, will be promptly notified to RAs, Ethics Committees, and Investigators, as appropriate.