Sex: F
Vaccine: TYP
Symptoms: Abdominal pain upper, Decreased appetite, Diarrhoea, Dyspepsia, Nausea
Clinical narrative: Suppressed appetite; Diarrhea; Nauseous; Stomach pain; Little indigestion; Spontaneous report received 31JUL2020.  A female consumer reported that she experienced little indigestion (PT: Dyspepsia), nausea (PT: Nausea), diarrhea (PT: Diarrhoea), stomach pain (PT: Abdominal pain upper), suppressed appetite (PT: Decreased appetite), following immunization with Vivotif. The consumer took first two doses of Vivotif on 25JUL2020 and 27JUL2020. On 27JUL2020, she realized that she had a stomach pain. On 29JUL2020, she took third dose of Vivotif and on the same day, she reported that the stomach pain got worse. On 30JUL2020, she felt nauseous, her appetite was suppressed, and she didn't eat anything, and she had diarrhea. On 31JUL2020, she took last dose of Vivotif. Additionally, she stated that she just had a little indigestion left. She had no vomiting.  She stated that she did not receive any treatment for the reported events. Action taken with Vivotif with respect to the reported events was dose not changed. She had recovered from the event "nausea" and the events of "diarrhea", "stomach pain" and "suppressed appetite" were almost resolved. The outcome of the event "little indigestion" was resolving at the time of report.  Moreover, she reported that she has had acid reflux for the past couple of months.  Concomitant medication included omeprazole (20 mg; once a day)  Company Comment: A consumer had little indigestion (dyspepsia), nausea, diarrhoea, stomach pain (abdominal pain upper), suppressed appetite (decreased appetite) after taking two doses of Vivotif. In response to the events, consumer continued taking the remaining two doses of Vivotif. After a few days of completing Vivotif, nausea has resolved, abdominal pain upper, decreased appetite, diarrhoea were almost resolved and she still had little indigestion left. This consumer has a history of acid reflux for a few months before starting vivotif. Considering the case information, and potential of vivotif to cause nausea, diarrhoea, abdominal pain upper, decreased appetite, the causality of all these events is assessed as possible (confounded by underlying acid reflux condition). The causality of dyspepsia is assessed as possible (role of vivotif cannot be ruled out and confounded by underlying acid reflux condition).; Sender's Comments: A consumer had little indigestion (dyspepsia), nausea, diarrhoea, stomach pain (abdominal pain upper), suppressed appetite (decreased appetite) after taking two doses of Vivotif. In response to the events, consumer continued taking the remaining two doses of Vivotif. After a few days of completing Vivotif, nausea has resolved, abdominal pain upper, decreased appetite, diarrhoea were almost resolved and she still had little indigestion left. This consumer has a history of acid reflux for a few months before starting vivotif. Considering the case information, and potential of vivotif to cause nausea, diarrhoea, abdominal pain upper, decreased appetite, the causality of all these events is assessed as possible (confounded by underlying acid reflux). The causality of dyspepsia is assessed possible (role of vivotif cannot be ruled out and confounded by underlying acid reflux).