Sex: F
Vaccine: COVID19
Symptoms: HIV test, Haematuria, Hepatitis B virus test, Hepatitis C virus test, Immunology test
Clinical narrative: Anti-GBM nephritis with mesangial IgA deposits; acute kidney injury; gross hematuria; anorexia; fevers; nausea; This literature-non-study case was reported in a literature article and describes the occurrence of ANTI-GLOMERULAR BASEMENT MEMBRANE DISEASE (Anti-GBM nephritis with mesangial IgA deposits) and ACUTE KIDNEY INJURY (acute kidney injury) in a female patient of an unknown age who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.   LITERATURE REFERENCE: .. Anti-GBM nephritis with mesangial IgA deposits after SARS-CoV-2 mRNA vaccination. Kidney Int. 2021     No Medical History information was reported.   On an unknown date, the patient received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) 1 dosage form. On an unknown date, received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. On an unknown date, the patient experienced ANTI-GLOMERULAR BASEMENT MEMBRANE DISEASE (Anti-GBM nephritis with mesangial IgA deposits) (seriousness criteria hospitalization and medically significant), ACUTE KIDNEY INJURY (acute kidney injury) (seriousness criteria hospitalization and medically significant), HAEMATURIA (gross hematuria), DECREASED APPETITE (anorexia), PYREXIA (fevers) and NAUSEA (nausea). The patient was treated with METHYLPREDNISOLONE for Adverse event, at an unspecified dose and frequency and CYCLOPHOSPHAMIDE (CYTOXAN) for Adverse event, at an unspecified dose and frequency. At the time of the report, ANTI-GLOMERULAR BASEMENT MEMBRANE DISEASE (Anti-GBM nephritis with mesangial IgA deposits), ACUTE KIDNEY INJURY (acute kidney injury), HAEMATURIA (gross hematuria), DECREASED APPETITE (anorexia), PYREXIA (fevers) and NAUSEA (nausea) outcome was unknown.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On an unknown date, Biopsy kidney: crescentic glomerulonephritis (abnormal) a diffusely crescentic glomerulonephritis, with 100% active cellular crescents and no significant chronic injury. On an unknown date, Blood creatinine: 7.8 mg/dl (High) 7.8 mg/dl. On an unknown date, HIV test: negative (Negative) Negative. On an unknown date, Hepatitis B virus test: negative (Negative) negative. On an unknown date, Hepatitis C virus test: negative (Negative) negative. On an unknown date, Immunology test: linear staining of gbms for igg (3+) (abnormal) linear staining of GBMs for IgG (3+), and granular mesangial staining for IgA (23+), with associated rare mesangial deposits by electron microscopy. On an unknown date, Protein urine: negative (Negative) negative. On an unknown date, Serology test: negative (Negative) anti-neutrophil cytoplasmic autoantibody (ANCA), anti-nuclear antibody (ANA), antidouble-stranded DNA, complements, serum protein electrophoresis were negative. On an unknown date, Urine protein/creatinine ratio: 1.9 g/g (abnormal) 1.9 g/g.     For mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular), the reporter considered ANTI-GLOMERULAR BASEMENT MEMBRANE DISEASE (Anti-GBM nephritis with mesangial IgA deposits), ACUTE KIDNEY INJURY (acute kidney injury), HAEMATURIA (gross hematuria), DECREASED APPETITE (anorexia), PYREXIA (fevers) and NAUSEA (nausea) to be possibly related.    Reportedly patient had no past medical history of  coronavirus disease 2019 (COVID-19) infection or medication use.  No concomitant medication was reported.  Additional treatment included plasmapheresis and hemodialysis. Patient remained dialysis dependent.  Very limited information regarding these events has been provided at this time. Additional information required. A causal relationship cannot be excluded for the events of nausea and pyrexia.   Most recent FOLLOW-UP information incorporated above includes: On 23-Jun-2021: Email with Agreement received from team, Initiative ; Sender's Comments: Very limited information regarding these events has been provided at this time. Additional information required.A causal relationship cannot be excluded for the events of nausea and pyrexia.