Age: 67.0
Sex: F
Vaccine: VARZOS
Symptoms: Chills, Dizziness, Dyspnoea, Fall, Feeling abnormal
Clinical narrative: Dizzy / Dizziness; Nauseous; Vomit; Fell in bathroom a few times; Feeling hot; Muscle aches; Sore arm/feet hurt; Severe flu like symptoms; Headache; Chills; Feeling off center; vertido; hyperventilating; not able to catch her breath; feel thristy; breathing more deeply and through her mouth; This case was reported by a physician via call center representative and described the occurrence of pain in arm in a 67-year-old female patient who received Herpes zoster (Shingrix) for prophylaxis.   The patient's past medical history included breast cancer. Previously administered products included Shingrix (received 1st dose 2 months ago,refer case US2019AMR168728).   In September 2019, the patient received the 2nd dose of Shingrix. On 12th September 2019, less than a day after receiving Shingrix, the patient experienced pain in arm, influenza-like symptoms, headache, chills, muscle pain and feeling hot. On 13th September 2019, the patient experienced dizziness, nausea, vomiting and fall. In September 2019, the patient experienced feeling abnormal, vertigo, hyperventilation, shortness of breath, thirst and mouth breathing. The patient was treated with ranitidine, antiinflammatory/antirheumatic products (Anti-Inflammatory), non-drug therapy (Heating Pad (Nos)) and non-drug therapy (Ice Pack (No Medication)). Rechallenge with Shingrix was positive. On an unknown date, the outcome of the pain in arm, chills, nausea, vomiting, muscle pain, fall, feeling hot, feeling abnormal, vertigo, hyperventilation and shortness of breath were recovered/resolved and the outcome of the influenza-like symptoms, thirst and mouth breathing were unknown and the outcome of the headache and dizziness were not recovered/not resolved.   It was unknown if the reporter considered the pain in arm, influenza-like symptoms, headache, chills, dizziness, nausea, vomiting, muscle pain, fall, feeling hot, feeling abnormal, vertigo, hyperventilation, shortness of breath, thirst and mouth breathing to be related to Shingrix.  Additional details were provided as follows: The patient had injections in her right arm.  The patient received Shingrix and had sore arm and experienced severe flu like symptoms. All the symptoms she experienced are listed in this report under adverse events.  The patient felt so dizzy that she fell in her bathroom a few times. The dizziness caused her to be nauseous and vomit. She has been taking Ranitidine and anti-inflammatories and they have helped with the nausea and muscle aches. All symptoms have resolved except for headache, dizziness and nausea which are still present on and off. She described it as still feeling off center. She used a heating pad and ice packs for the muscle aches. She said her feet also hurt but they always hurt. The reporter stated that the dizziness has gotten better and was more like vertigo at the time of reporting. She states she has been drinking alot and feels thirsty since receiving Shingrix. It could be that she was breathing more deeply and through her mouth, hyperventilating, not able to catch her breath when she was vomiting. The reporter consented to follow up.