Age: 64.0
Sex: F
Vaccine: COVID19, COVID19
Symptoms: Blood pressure measurement, COVID-19, Investigation, Vaccination failure
Clinical narrative: Her glaucoma eye pressure was elevated too/eye pressure was so high; she experienced elevated blood pressure (BP); experienced breaking her teeth and also cavities/one of my left real molars just the inside wall of my molar just shear glide of the tooth/had 4 more teeth cracked, the root had cracked; experienced breaking her teeth and also cavities; This is a spontaneous report received from a contactable reporter(s) (Nurse) from medical information team. The reporter is the patient.  A 64-year-old female patient received bnt162b2 (BNT162B2), on 18Dec2021 as dose 3 (booster), single (Lot number: FL3197, Expiration Date: 31Dec2022) at the age of 64 years intramuscular, in left deltoid for covid-19 immunisation. The patient's relevant medical history included: "Hypertension" (unspecified if ongoing); "glaucoma" (unspecified if ongoing). Concomitant medication(s) included: LOSARTAN taken for hypertension. Vaccination history included: bnt162b2 (DOSE 2, SINGLE, Pfizer COVID-19 Vaccine Second Dose:, Date: 08Mar2021, LOT#: EN6206, Expiration Date: 30Jun2021), administration date: 08Mar2021, when the patient was 64-year-old, for COVID-19 immunization; bnt162b2 (DOSE 1, SINGLE, Pfizer COVID-19 Vaccine First Dose :  , Date: 12Feb2021, LOT#: EL9261, Expiration Date: 31May2021), administration date: 12Feb2021, when the patient was 64-year-old, for COVID-19 immunization. The following information was reported: TOOTH FRACTURE (medically significant) with onset Dec2021, outcome "unknown", described as "experienced breaking her teeth and also cavities/one of my left real molars just the inside wall of my molar just shear glide of the tooth/had 4 more teeth cracked, the root had cracked"; GLAUCOMA (medically significant) with onset Jan2022, outcome "unknown", described as "Her glaucoma eye pressure was elevated too/eye pressure was so high"; DENTAL CARIES (non-serious) with onset Dec2021, outcome "unknown", described as "experienced breaking her teeth and also cavities"; BLOOD PRESSURE INCREASED (non-serious) with onset Jan2022, outcome "unknown", described as "she experienced elevated blood pressure (BP)". The events "her glaucoma eye pressure was elevated too/eye pressure was so high", "experienced breaking her teeth and also cavities/one of my left real molars just the inside wall of my molar just shear glide of the tooth/had 4 more teeth cracked, the root had cracked", "experienced breaking her teeth and also cavities" and "she experienced elevated blood pressure (bp)" required physician office visit. The patient underwent the following laboratory tests and procedures: Blood pressure measurement: elevated; Ophthalmological examination: elevated. Therapeutic measures were taken as a result of glaucoma, tooth fracture, dental caries, blood pressure increased.  Clinical course: A nurse practitioner called in as a patient. She has concerns about the Pfizer booster shot she received. Her 1st two doses of Pfizer Covid vaccines, she has no issues at all, she did not experience any adverse reactions. Her 3rd shot is a Pfizer Covid vaccine booster on 18Dec2021. She was not told if it was Bivalent or not. Her 4th shot was a Moderna Bivalent in Nov2022, she got no issues with that too. With regards to the booster though, after 3 weeks of getting it, she experienced elevated blood pressure (BP). Her glaucoma eye pressure was elevated too. Her specialist recommended surgery for the eye. After 1 week she experienced breaking her teeth and also cavities. She just wants to know if these are common side effects or related to the booster or not. She added that her medical condition was stable for 10 years with the medication she was taking, her BP was normal for 7 years with the medication she was taking as well. A specialist told her she can have laser treatment for her eyes to bring the pressure down. The last 18 months the same week the BP and eye press were up. She had put a crown on her left rear molar tooth the same week sheared the tooth. Since then, 5 teeth have cracked, and she never had that before. The consumer (Nurse Practitioner) further stated, "I have had a question about the Pfizer booster shot, I was able to get the first two Pfizer COVID-19 Vaccines without any reactions or side effect at all and I got the Bivalent without any reaction at all but when I got the COVID, the Pfizer COVID Booster shot and this was on 18Dec2021, three week after I got that shot, I was at my Cardiologist office and she noted that my blood pressure was very high and my blood pressure is not stable for several years, so she had to change blood pressure medication and increases, 5 weeks later  I was at my glaucoma specialist office and they noted that my eye pressure was so high they wanted to do surgery on my eyes and my glaucoma pressure had been stable for about 10 years at that point and that same week I also one of my left real molars just the inside wall of my molar just shear glide of the tooth and I had to have the tooth cleaned and a crown put on it since then I have had 4 more teeth cracked, the root had cracked, the front teeth which never had cavity in gum ever, one chipped this summer and then about a month the other one chipped and so I am trying to figure out, have you heard of this happening to anyone else after a COVID booster or Pfizer Booster because I am an Oncology Nurse I know sometimes things can happen that are totally unrelated but I am just asking a question specially where you are at adverse reaction division have you heard of this happening to anyone else?". The consumer further stated, "the first and second Pfizer COVID-19 Vaccines were in Feb2021 and Mar2021 and then in Dec2021, I had the Pfizer Booster COVID-19 Vaccine and that was the one that I had the reaction right, everything seems to be changed after I had, three weeks after I had that shot, my blood pressure was very high, my eye pressure was very high, I started cracking teeth and still things to be happening over 18 months I have cracked 5 teeth, it never happened before and then Sep2022, I had the COVID Bivalent had no problem with that at all the first, second vaccines and the bivalent I was perfect after them but it was after the booster that is when I started, three weeks after that I started having all of these problems. Has anybody else reported these symptoms after getting the Bivalent because it did not happen right away like 3 weeks after the booster and all the problems started". Regarding the treatment, consumer stated, "the other thing I have is Glaucoma and my glaucoma pressure have been stable for 10 years and 3 weeks after the shot the booster, my eye pressure was so high they wanted to do surgery on my eye and I got a second opinion and I went to a specialist in and she said that I could do a laser treatment rather than a surgery which I was very happy about and so that is what I get and they added on another glaucoma medication, so I was taking 2 eye drops, one is Vyzulta and that is 1 drop in each eye at bed time and then the other one that they added on was Rhopressa and I do 1 drop in each eye at bed time".; Sender's Comments: Based on available information, the reported events are assessed as unrelated to BNT162B2: glaucoma aggravated and elevated blood pressure can be attributed to the course of the underlying glaucoma and hypertension, respectively; broken teeth and tooth cavity are intercurrent conditions. Case will be reassessed if additional information becomes available   The impact of this report on the benefit/risk profile of the Pfizer product is evaluated as part of Pfizer procedures for safety evaluation, including the review and analysis of aggregate data for adverse events. Any safety concern identified as part of this review, as well as any appropriate action in response, will be promptly notified to regulatory authorities, Ethics Committees, and Investigators, as appropriate.