Sex: U
Vaccine: MMR
Symptoms: Measles antibody, Vaccination failure
Clinical narrative: death; suspected vaccination failure; measles; This serious case was reported in a literature article and described the occurrence of death in a patient who received MMR (MMR vaccine) for prophylaxis.    The patient received the 1st dose of MMR vaccine on an unknown date, for prophylaxis. On an unknown date, an unknown time after receiving MMR vaccine, the patient experienced death (Verbatim: death) (serious criteria death and GSK medically significant), vaccination failure (Verbatim: suspected vaccination failure) (serious criteria GSK medically significant) and measles (Verbatim: measles). The outcome of the vaccination failure and measles were not reported. The reported cause of death was death.   Diagnostic results (reference ranges are provided in parenthesis if available):  Blood immunoglobulin G- not reported. Blood test- not reported. Measles antibody- not reported.                                                                                                     The reporter considered the death, vaccination failure and measles to be related to MMR vaccine.   The company considered the death and vaccination failure to be unrelated to MMR vaccine. The company considered the measles to be related to MMR vaccine.   Additional Information: GSK Receipt Date: 16-SEP-2024  This case corresponds to a one dose vaccinated patient whose death was reported.  The aim of the article was for 2001-2022.  Author included measles cases reported from 2001-2022. Breakthrough measles was defined as cases with more than or equal to 1 documented dose of measles-containing vaccine, classic measles as the presence of rash, fever, and more than or equal to 1 symptoms (cough, coryza, or conjunctivitis), and severe disease as the presence of pneumonia, encephalitis, hospitalization, or death. Vaccinated cases with low and high avidity IgG were classified as primary (PVF) and secondary (SVF) vaccine failures, respectively. A total of 4,056 confirmed measles cases were reported during 2001-2022, among whom 2,799 (69percent) were unvaccinated, 258 (6percent) had received 1-dose of a measles-containing vaccine, 217 (5percent) had received more than or equal to2 doses, and 782 (19percent) had unknown vaccination status; the median age for these four groups was 5 (interquartile (IQR): 1-14), 11 (IQR: 2-34), 23 (IQR: 18-30), and 34 (IQR: 24-45) years, respectively. Among case-patients aged less than or equal to15 months, 16 months-19 years, and more than or equal to20 years, 2percent, 11percent and 18percent had received more than or equal to1 doses of a measles-containing vaccine, respectively.  There was 3 deaths were reported in which one patient was 1-dose vaccinated and had experienced measles.  This case was considered to be a suspected vaccination failure case, as time to onset and laboratory test was unknown.; Sender's Comments: Vaccination failure is an listed event which due to the following criteria (insufficient information provided about the clinical description, details regarding completion of primary vaccination schedule, time to onset and laboratory confirmation of disease.) is considered unrelated to GSK MMR vaccine. Death is an unlisted event which is considered unrelated to GSK MMR vaccine.; Reported Cause(s) of Death: death