Age: 65.0
Sex: F
Vaccine: VARZOS, VARZOS
Symptoms: Blood test, Computerised tomogram, Injection site pruritus, Lymphadenopathy, Magnetic resonance imaging
Clinical narrative: Swollen lymph nodes in her armpits, groin, and neck area/Supraclavicular swelling; Lungs were hyperinflated; Painful lymph nodes in her armpits, groin, and neck area; Itching; Achiness all over; Exhausted; Feeling crummy; Pain at injection site; This case was reported by a consumer via call center representative and described the occurrence of enlargement of lymph nodes in a 65-year-old female patient who received Herpes zoster (Shingrix) for prophylaxis.   On 12th February 2022, the patient received the 2nd dose of Shingrix (intramuscular) 50 µg. On 13th February 2022, 1 days after receiving Shingrix, the patient experienced feeling bad and injection site pain. On 19th February 2022, the patient experienced pruritus, general body pain and exhaustion. On 1st March 2022, the patient experienced enlargement of lymph nodes, lung hyperinflation and lymph node pain. On 14th February 2022, the outcome of the feeling bad was recovered/resolved. On an unknown date, the outcome of the enlargement of lymph nodes, pruritus, general body pain, exhaustion, lung hyperinflation and lymph node pain were not recovered/not resolved and the outcome of the injection site pain was recovered/resolved.   The reporter considered the enlargement of lymph nodes, feeling bad, pruritus, general body pain, exhaustion, lung hyperinflation and lymph node pain to be possibly related to Shingrix. The reporter considered the injection site pain to be related to Shingrix.  Additional details reported were as follows: The patient self-reported this case. The patient received Shingrix into her right arm at her pharmacy. The reporter could not provide the lot or expiration date of the vaccine  The day after receiving the vaccine, patient feeling crummy and had pain at the injection site. After 1 day patient felt better, but then one week later on 19th February 2022, the pain in her arm at the injection site, transitioned into an itching that was not resolved. On 19th February 2022, 7 days after vaccination, the patient also began to feel achiness all over and exhausted.  The reporter stated that, she had been to her general practitioner, a pulmonologist, and an ENT for her symptoms. The patient had a chest x-ray and CT scan of her lungs which showed they were hyperinflated. Around 1st March 2022, ten days after the exhaustion began, the reporter stated patient been to had painful, swollen lymph nodes in her armpits, groin, and neck area and was diagnosed with supraclavicular swelling which was unresolved. The reporter's ENT had ordered a MRI. The reported stated that she feels these event could all potentially be due to the Shingrix vaccine she received. The reporter did not give consented to contact her HCP but stated s, herself, would like a call from the safety department to discuss. GSK note- there is descripancy in the reported onset date of painful, swollen lymph nodes as in structured field date is mentioned as 1st Mar 2022 and in narrative it is 10th March 2022. The onset date for these events captured as per structured field.