Age: 42.0
Sex: M
Vaccine: COVID19
Symptoms: Dyspnoea, Echocardiogram, Electrocardiogram, Myocarditis, Pyrexia
Clinical narrative: Cardiogenic shock; biventricular myocarditis; Global biventricular dysfunction; tachycardia; chest pain; dyspnea; Fever; This literature-non-study case was reported in a literature article and describes the occurrence of CARDIOGENIC SHOCK (Cardiogenic shock), MYOCARDITIS (biventricular myocarditis) and VENTRICULAR DYSFUNCTION (Global biventricular dysfunction) in a 42-year-old male patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 vaccination. The occurrence of additional non-serious events is detailed below.      No Medical History information was reported.   On an unknown date, the patient received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On an unknown date, received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular) dosage was changed to 1 dosage form. On an unknown date, the patient experienced CARDIOGENIC SHOCK (Cardiogenic shock) (seriousness criteria death and medically significant), MYOCARDITIS (biventricular myocarditis) (seriousness criteria death and medically significant), VENTRICULAR DYSFUNCTION (Global biventricular dysfunction) (seriousness criterion death), TACHYCARDIA (tachycardia), CHEST PAIN (chest pain), DYSPNOEA (dyspnea) and PYREXIA (Fever). The patient died on an unknown date. The reported cause of death was biventricular myocarditis, Cardiogenic shock and global biventricular dysfunction. An autopsy was performed. At the time of death, TACHYCARDIA (tachycardia), CHEST PAIN (chest pain), DYSPNOEA (dyspnea) and PYREXIA (Fever) outcome was unknown.      DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): In 2021, Angiocardiogram: normal (normal) revealed no coronary artery disease.. In 2021, Angiogram: normal (normal) revealed no coronary artery disease.. In 2021, Autopsy: biventricular myocarditis (abnormal) An inflammatory infiltrate admixed with macrophages, T-cells, eosinophils, and B cells was observed. In 2021, Echocardiogram: abnormal (abnormal) global biventricular dysfunction (ejection fraction, 15%), normal ventricular dimensions, and left ventricular hypertrophy. In 2021, Electrocardiogram: abnormal (abnormal) showed diffuse ST-segment elevation. In 2021, SARS-CoV-2 test: negative (Negative) Negative for SARS-CoV-2 and no other causes were identified.. In 2021, Serology test: abnormal (abnormal) no other causes were identified..     For mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular), the reporter did not provide any causality assessments.   Patient had not reported a viral prodrome  The letter stated that a direct causal relationship could not be definitively established because they did not perform testing for viral genomes or autoantibodies in the tissue specimens. However, no other causes were identified by PCR assay or serologic examination.  Concomitant product use was not provided by the reporter.   ? No treatment information was provided.  Very limited information regarding this event/s has been provided at this time.  Further information has been requested. Further information is not expected.; Sender's Comments: Very limited information regarding this event/s has been provided at this time.  Further information has been requested. Further information is not expected.; Reported Cause(s) of Death: biventricular myocarditis; Cardiogenic shock; Global biventricular dysfunction