Age: 60.0
Sex: M
Vaccine: COVID19
Symptoms: Interchange of vaccine products, Secondary immunodeficiency, Transplant
Clinical narrative: transplant that wiped his entire immune system; Interchange of vaccine products; Revaccination with different COVID-19 vaccine; This spontaneous case was reported by a pharmacist and describes the occurrence of SECONDARY IMMUNODEFICIENCY (transplant that wiped his entire immune system) in a 60-year-old male patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 prophylaxis. The occurrence of additional non-serious events is detailed below.     It was unknown if the patient received any other vaccines in the 4 weeks prior to COVID-19 vaccine.  Concomitant products included TOZINAMERAN (PFIZER BIONTECH COVID-19 VACCINE) for an unknown indication.   On 18-Aug-2021, the patient received first dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 15-Sep-2021, received second dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 02-Sep-2022, received fourth dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. On 12-Jan-2022, the patient experienced INTERCHANGE OF VACCINE PRODUCTS (Interchange of vaccine products) and COVID-19 IMMUNISATION (Revaccination with different COVID-19 vaccine). On an unknown date, the patient experienced SECONDARY IMMUNODEFICIENCY (transplant that wiped his entire immune system) (seriousness criterion medically significant). At the time of the report, SECONDARY IMMUNODEFICIENCY (transplant that wiped his entire immune system), INTERCHANGE OF VACCINE PRODUCTS (Interchange of vaccine products) and COVID-19 IMMUNISATION (Revaccination with different COVID-19 vaccine) outcome was unknown.        For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown), the reporter did not provide any causality assessments.   Concomitant medication was not provided.  On-12-Jan-2022 the patient received Pfizer booster and patient had transplant that wiped entire immune system. Treatment information was not provided. Company comment-This spontaneous case concerns a male patient aged 60 years with no medical history reported, who experienced the unexpected serious (Medically significant) event of Secondary immunodeficiency that occurred in the context of mRNA-1273 vaccination in covid -19 vaccination series. Latency cannot be assessed since onset date of event was not disclosed. Patient had received initial two doses with mRNA-1273 at an interval of 28 days, third dose of Tozinameran vaccine about 4 months later, followed by fourth dose of mRNA-1273 about 9 months later. So Interchange of vaccine products/ Covid-19 immunization was also noted. It was reported that patient got the primary series with Moderna. But then patient had a transplant that wiped patient's entire immune system, patient's doctor wanted patient to repeat the series. They initiated it and gave patient another first dose of Moderna. No further information was available for medical review. The benefit-risk relationship of mRNA-1273 vaccine is not affected by this report.   This case was linked to MOD-2023-715987 (Patient Link).