Sex: M
Vaccine: COVID19
Symptoms: Neutrophil count, Physical examination, Red blood cell sedimentation rate, Rheumatoid arthritis, Rheumatoid factor
Clinical narrative: developed an acute flare of his rheumatoid arthritis 12 h after the second BNT162b2 vaccination; This is a literature report from the Lancet Rheumatol, 2021, DOI: 10.1016/S2665-9913(21)00108-9 entitled Flare of rheumatoid arthritis after COVID-19 vaccination.  The authors present a case of a male, aged 55 years, with non-erosive, seropositive rheumatoid arthritis (positive for rheumatoid factor, anticyclic citrullinated peptide antibodies, antinuclear antibodies, and anti-Ro antibodies) who had been in sustained clinical remission for more than 2 years and developed an acute flare of his rheumatoid arthritis 12 h after the second BNT162b2 vaccination. The patient had been in clinical remission on upadacitinib monotherapy since July, 2018. At his last clinic visit in September, 2020, his physical exam showed no active synovitis or joint effusions, and his disease activity scores were consistent with remission (clinical disease activity index=0; disease activity score of 28 joints with C-reactive protein=1.21). The patient had no known exposures to SARS-CoV-2 and had tested negative for SARS-CoV-2 by PCR in April, 2020, when screened for work. He received the first BNT162b2 vaccine on Dec 23, 2020, after which he developed minor arthralgias that resolved within 1 day. He received the second vaccine dose on Jan 13, 2021, and within 12 h developed clinically significant pain and swelling in the right knee. He had no other joint pain, swelling, or stiffness. He took ibuprofen and prednisone 5 mg soon after the pain and swelling began, but his symptoms persisted, so he contacted the authors' office the next day and the authors advised him to increase his prednisone to 10 mg daily. Despite the increased medication, he continued to have clinically significant symptoms, so the authors asked him to come to the authors' clinic for an ultrasound evaluation. He had continued on his usual rheumatoid arthritis treatment between the two vaccinations. The patient came to the authors' clinic on Jan 22, 2021- 30 days after receiving the first BNT162b2 vaccination, and 9 days after the second vaccination-he had clinically significant swelling and warmth over the right knee with pain on flexion and extension of the knee. There was no tenderness, swelling, or erythema of any other joints. Ultrasound evaluation of the right knee showed a moderate to large compressible hypoechoic effusion in the suprapatellar recess that extended from the suprapatellar bursa proximally 5.2 cm deep to the quadriceps tendon and involved the medial and lateral gutter (appendix). There was increased power Doppler signal in the effusion in the lateral gutter. Additionally, there was a large effusion in the posterior knee deep to the semimembranosus tendon, consistent with a popliteal cyst. Arthrocentesis of the right knee showed 24 mL of inflammatory-appearing effusion (appendix). Synovial fluid studies showed a cell count of 24 385 cells per uL, of which 62% were neutrophils, 30% were monocytes, 8% were lymphocyte, and none were eosinophils. Crystal exam was negative, and no organisms were identified on bacterial or fungal cultures. He had a normal complete metabolic panel and complete blood count, elevated C-reactive protein (8.0 mg/L; increased from 0.3 mg/L on Sept 9, 2020), and erythrocyte sedimentation rate 39 mm/h (28 mm/h on June 10, 2020). The patient tested negative for SARS-CoV-2 IgG antibody on day 30, but subsequently tested positive on Feb 3, 2021 (42 days after his first vaccination). His rheumatoid arthritis was well controlled before the vaccination, and there were no other inciting events, so the authors believe that this flare might have been triggered by his immune response to a component of the BNT162b2 vaccine. BNT162b2 contains mRNA encoding for the SARS-CoV-2 spike protein encapsulated in lipid nanoparticles, in addition to other components that stabilise the vaccine in the circulation and promote its uptake into cells by endocytosis. Although the mechanism of flare is not known, one could speculate that one of these components might have had nonspecific adjuvant effect, or there could have been molecular mimicry between the viral spike peptides and the patients self-peptides, activating a flare. However, the authors cannot exclude the possibility that the timing of the flare with regard to vaccination was coincidental. The patient was treated with intra-articular steroids with rapid improvement, and he is once again in clinical remission.; Sender's Comments: Based on the temporal association, the causal relation between that the reported event Rheumatoid arthritis flare up considered related to BNT162B2 (COVID-19 mRNA VACCINE).