Age: 23.0
Sex: F
Vaccine: HPV9
Symptoms: Oestradiol decreased, Ovarian failure, Pregnancy
Clinical narrative: I had 3 injections of the Gardasil Vaccine. The first dose was on 6/19/2007; second dose on 8/16/2007; third dose on 1/14/2008.  The lot number is not located on my progress notes. I do have the progress notes from my OB-GYN for proof of these injections.   Since being vaccinated with Gardasil (which was a series of 3 vaccinations), I developed irregular periods. I have suffered with infertility for several years now. Of course I did not know I was infertile until many years later when trying to conceive. My husband and I stopped using condoms in 2013. After 3 years of no success, in  2016, we decided to dig a little deeper and started testing various things. First we started with checking my husband's sperm which was fine. Then, we began testing me. During my first visit with the reproductive endocrinologist, I was told that my FSH was around 9 and my AMH was 0.065. I was told that I had a greater than 0%, but less than 5% chance of conception. The reproductive endocrinologist also told me that I had so few eggs, that I would not be a candidate for IVF. He said I had diminished ovarian reserve. He said with an AMH of 0.065, I had likely had a very low egg supply even in my mid-twenties. Shortly after, I became spontaneously pregnant (no fertility treatment), but very quickly miscarried at just a few weeks pregnant. Then I went through several years of testing, surgeries and seeing various doctors to try and figure out why I wasn't able to conceive, as I was diagnosed as having "unexplained infertility of unknown etiology".  Then in 2018, I became pregnant without fertility treatment.  I delivered my son.  Eleven months later after his delivery, I stopped having periods all together (May 2020). I notified my OB-GYN who did some bloodwork (estradiol and FSH) to determine if I was in perimenopause because I began having hot flashes, developed a bald spot on my head, mood swings, emotional, low libido.  One of my levels came back "pre-menopausal" and the other was in the menopausal range. She did a repeat bloodwork a month later  and both of my levels came back in the menopausal range. My estradiol was less than 15 and my FSH was 101 (this is at 37 years of age). She diagnosed me with primary ovarian insufficiency (POI) also known as premature ovarian failure. I then went back to see a reproductive endocrinologist to get recommendations on hormone replacement therapy. The reproductive endocrinologist tested me for Fragile X and Turner syndrome and adrenal antibodies; all of these were negative. He said the cause of my POI was "idiopathic".  I now am on hormone replacement therapy and will have to remain on it into my 50's (I am only 37 years old).  I was also just diagnosed with hypothyroidism as my hormones are a "wreck". I truly feel that the Gardasil vaccine has had an impact on my life and my ability to have children. I thank God that he blessed me with a child.  Infertility has ruined my life in so many ways and now this new diagnosis of POI is having a huge impact on my life from my energy level, mood swings, libido, hot flashes and the list goes on and on.  Add to that the financial impact of trying fertility treatments and the number of medications I have tried over the years, as well as the number of medications I will have to be on for a very long time due to the POI diagnosis.