Sex: F
Vaccine: COVID19
Symptoms: Oropharyngeal discomfort, Paraesthesia oral, Pharyngeal swelling, Throat irritation, Throat tightness
Clinical narrative: flushing/ facial flushing; Hives; felt warm; short of breath/ audibly gasping for air; wheeze; throat tightening; throat got so swollen and itchy; throat got so swollen and itchy; could not swallow; This is a spontaneous report from a Pfizer-sponsored program Corporate (Pfizer) Social Media Platforms. A non-contactable consumer reported that a 40-year-old female patient received BNT162B2 (PFIZER-BIONTECH COVID-19 VACCINE; lot number and expiry date were not reported), via an unspecified route of administration on an unspecified date at a single dose for COVID-19 immunisation. Medical history included food severe allergic reaction to influenza vaccine with eggs preservative. Concomitant medications were not reported. The patient previously took influenza vaccine and experienced severe allergic reaction to the eggs preservative. The patient received BNT162B2 vaccine and informed of prior history of severe allergic reaction to influenza vaccine with eggs preservative. She has previously received flu vaccine without egg without problem. Due to her prior history of severe allergic reaction/ anaphylaxis to another vaccine, in this case flu vaccine with eggs, it was noted to proceed with caution. She was told that the vaccination could be differed until more information became available but opted to proceed with receiving the vaccine and be observed for 30 minutes. The patient developed throat tightening approximately 20 minutes after vaccination. She received EpiPen within one minute of symptoms and was sent to the emergency room immediately in a wheel chair by Nursing staff. She was evaluated in the emergency department and was hemodynamically stable. She was given IV Benadryl and was stable throughout observation. The patient then reported that 40 minutes after injection, her throat and tongue started to feel weird and tight. The pharmacy at her work hospital gave her 25 mg Benadryl and 650mg Tylenol. At about 1 hour 45 minute after injection, her throat got so swollen and itchy to the point that she could not swallow. She went to the nearest emergency room hospital and they administered decadron and Pepcid orally, and Toradol intramuscularly. On an unspecified date, the patient also reported that 5 minutes after the vaccine administration, she developed flushing, hives, felt warm and eventually short of breath. She started to wheeze and was wheeled into the emergency room with complaint of "cannot breathe, while holding throat and thrashing with facial flushness noted." She took two Benadryl and had several epinephrine shots. She was discharged from the emergency room but later that day, she started to feel short of breath again. In the emergency department, she was audibly gasping for air, however had no wheezing, had a normal saturation and normal blood pressure. She had taken another dose of her EpiPen intramuscularly and diphenhydramine 50mg by mouth prior to coming. She was then admitted to the hospital for further observation. While on the floor, she started to feel short of breath again (about 9am on 18Dec2020), which required an "RRT." The patient received another dose of diphenhydramine IV, methylprednisolone 125mg IV and several doses of IM epinephrine and also required oxygen. She was than transferred to an ICU for further care. Outcome of the events was unknown.   No follow-up attempts are possible, information about batch number cannot be obtained.