Age: 33.0
Sex: M
Vaccine: COVID19, COVID19, COVID19
Symptoms: Headache, Hepatic enzyme increased, Multiple organ dysfunction syndrome, Night sweats, Pyrexia
Clinical narrative: Autoimmune Disease; stills disease; HLH with multi organ failure; adult onset HLH disease; fatigue; blood counts were not what they should be; fever; night sweats; uncontrollable shivers; elevated liver enzymes; Abnormal labs with extremely high ferritin; thrombocytopenia; Intense headache; This is a spontaneous report received from contactable reporter(s) (Consumer or other non HCP) for a Pfizer sponsored program (001774). Other Case identifier(s): US-PFIZER INC-202200197237 (Pfizer Inc.).  A 33 year-old male patient received bnt162b2 (BNT162B2), administration date 25Aug2021 (Lot number: 39308A) at the age of 33 years as dose 2, single for covid-19 immunisation. Relevant medical history included: "Childhood asthma" (unspecified if ongoing). There were no concomitant medications. Vaccination history included: Bnt162b2 (Prev dose product: COVID 19, Prev dose brand: Pfizer, Prev dose brand name unknown: False, Prev dose lot number: EW0217, Prev dose Lot unknown: false, Prev dose dose number: 1), administration date: 04Aug2021, when the patient was 33 years old, for Covid-19 Immunization. The following information was reported: AUTOIMMUNE DISORDER (death, hospitalization, medically significant, life threatening), outcome "fatal", described as "Autoimmune Disease"; STILL'S DISEASE (death, hospitalization, life threatening), outcome "fatal", described as "stills disease"; MULTIPLE ORGAN DYSFUNCTION SYNDROME (death, hospitalization, medically significant, life threatening), outcome "fatal", described as "HLH with multi organ failure"; HAEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS (death, hospitalization, medically significant, life threatening), outcome "fatal", described as "adult onset HLH disease"; THROMBOCYTOPENIA (hospitalization, medically significant, life threatening) with onset 30Aug2021, outcome "unknown", described as "thrombocytopenia"; HEADACHE (hospitalization, life threatening) with onset 25Aug2021, outcome "unknown", described as "Intense headache"; PYREXIA (hospitalization, life threatening) with onset 30Aug2021, outcome "unknown", described as "fever"; FATIGUE (hospitalization, life threatening), outcome "unknown", described as "fatigue"; NIGHT SWEATS (hospitalization, life threatening) with onset 30Aug2021, outcome "unknown", described as "night sweats"; CHILLS (hospitalization, life threatening) with onset 30Aug2021, outcome "unknown", described as "uncontrollable shivers"; HEPATIC ENZYME INCREASED (hospitalization, life threatening) with onset 30Aug2021, outcome "unknown", described as "elevated liver enzymes"; SERUM FERRITIN INCREASED (hospitalization, life threatening) with onset 30Aug2021, outcome "unknown", described as "Abnormal labs with extremely high ferritin"; FULL BLOOD COUNT ABNORMAL (hospitalization, life threatening), outcome "unknown", described as "blood counts were not what they should be". The patient was hospitalized for autoimmune disorder, still's disease, multiple organ dysfunction syndrome, haemophagocytic lymphohistiocytosis, thrombocytopenia, pyrexia, fatigue, night sweats, chills, hepatic enzyme increased, serum ferritin increased, full blood count abnormal (hospitalization duration: 60 day(s)); the patient was hospitalized for headache (hospitalization duration: 60 day(s)). The events "thrombocytopenia", "intense headache", "fever", "fatigue", "night sweats", "uncontrollable shivers", "elevated liver enzymes", "abnormal labs with extremely high ferritin" and "blood counts were not what they should be" were evaluated at the physician office visit and emergency room visit. The patient underwent the following laboratory tests and procedures: full blood count abnormal: (unspecified date) abnormal; hepatic enzyme increased: (30Aug2021) elevated; pyrexia: (unspecified date) 103 Fahrenheit; serum ferritin increased: (30Aug2021) high. Therapeutic measures were taken as a result of haemophagocytic lymphohistiocytosis, thrombocytopenia, headache, pyrexia, fatigue, night sweats, chills, hepatic enzyme increased, serum ferritin increased. The patient date of death was 28Jan2022. The reported cause of death was autoimmune disorder, "Death", haemophagocytic lymphohistiocytosis, multiple organ dysfunction syndrome, still's disease. No autopsy was performed.  Clinical course: It was stated that, patient experienced Headache almost immediately, right away after vaccine. Fever started 48 hours after a few days later. Intermittent fever up to 103 F. Patient passed away on Friday, 28Jan. His first hospitalization was from 21Oct to 7Nov. Second resulted in 17-day hospitalization in October. Patient was diagnosed with a rare autoimmune disease called Still's Disease. After discharge, went home for about a month and was then re-hospitalized 14Dec. said it was later in December when was officially diagnosed with HLH. He received the HLH protocol treatment, which included chemotherapy. Unfortunately, none of the usual treatments worked. Diagnosed with HLH that was treatment resistant to 2004 HLH protocol, died 28Jan2022 due to multi organ failure AT 33-years-old. The doctors have agreed that the (Pfizer) COVID vaccine caused an immune response that led to the development of the autoimmune disease and HLH. Facility type vaccine: Pharmacy or Drug Store. No other vaccine in four weeks. No Other medications in two weeks.  No follow-up attempts are possible. No further information is expected.; Reported Cause(s) of Death: Autoimmune Disease; Death; HLH with multi organ failure; HLH with multi organ failure; Still's disease