Age: 59.0
Sex: F
Vaccine: COVID19
Symptoms: Investigation, Parosmia, Sensitisation, Sleep disorder
Clinical narrative: Super sensitive to smell; Have a persistent cough at night; So miserable; Can smell everything a mile ahead; Mostly cannot sleep; Severe drain; Allergies; Can't continuous breathe; This is a spontaneous report received from contactable reporter(s) (Nurse) from medical information team. The reporter is the patient.  A 60-year-old female patient received BNT162b2 (BNT162B2), in Aug2021 as dose number unknown (booster), single (Batch/Lot number: unknown) at the age of 59 years, in right arm for covid-19 immunisation. The patient had no relevant medical history. The patient took concomitant medications. Vaccination history included: BNT162b2 (DOSE 1, SINGLE, LOT: EL9267), administration date: 11Feb2021, when the patient was 59-year-old, for COVID-19 immunization; BNT162b2 (DOSE 2, SINGLE, LOT: EN6205), administration date: 04Mar2021, when the patient was 59-year-old, for COVID-19 immunization.  The following information was reported: DRUG HYPERSENSITIVITY (intervention required) with onset 2021, outcome "unknown", described as "Allergies"; PAROSMIA (non-serious) with onset 2021, outcome "unknown", described as "Can smell everything a mile ahead"; DYSPNOEA (intervention required) with onset 2021, outcome "unknown", described as "Can't continuous breathe"; SLEEP DISORDER (non-serious) with onset 2021, outcome "unknown", described as "Mostly cannot sleep"; ASTHENIA (non-serious) with onset 2021, outcome "unknown", described as "Severe drain"; FEELING ABNORMAL (non-serious) with onset 2021, outcome "unknown", described as "So miserable"; COUGH (non-serious) with onset Sep2021, outcome "unknown", described as "Have a persistent cough at night"; SENSITISATION (non-serious), outcome "unknown", described as "Super sensitive to smell". The patient underwent the following laboratory tests and procedures: scratch test: allergic to everything but cottonwool. Therapeutic measures were taken as a result of drug hypersensitivity, cough, asthenia.  Clinical course: Patient struggled with allergies since receiving Covid vaccine booster shot at the end of August 2021. Patient stated that 2-3 weeks after receiving booster shot, she began to have a persistent cough at night, although she has never had allergies. Her HCP suggested she see an ENT for a scratch test, which revealed her to be allergic to everything but cottonwool. Caller states she was currently taking four prescription medications and "cannot catch a break", is looking for online support group or suggestions, she is "so miserable", "can smell everything a mile ahead", mostly cannot sleep. Patient working with a vaccination clinic and she did working since the beginning and had vaccination with the Pfizer vaccine. Patient was allergic to everything it's not severe allergies but she just can't continuous breathe. Patient had taken the four anti-histamine (Further not clarified, hence captured as Unspecified Medication) and she can't sleep at night, patient did scratch test which showed that she was basically allergic to everything they tested her to and she never had in her life allergies. So, patient was just trying to figure out I she can get some kind of help she was just struggling her daily life. Patient was 60 years old and healthy, patient did nursing for 40 years and she just can't manage her allergies, patient can't sleep at night because as soon as she laid down she just severe drain and severe coughing and she just can't do it. she couldn't tell when exactly the cough began because at first she couldn't figure out what happened, and thought it could be a touch of the flu. She said the cough started in the beginning or middle of September 2021. Patient was taking Allegra, Singulair, Zyrtec, Benadryl and two nasal spray Nasocom and Nasacort (Treatment Drug). It was reported that patient took Lipidemic and she denied for having any health problem. Patient didn't have any lab test in two weeks. She stated at first she took Nyquil since she thought it was just a touch of flu, but it didn't work. She said 2-3 weeks after having symptoms started her primary care provider suggested she have an immunologist see her, but they don't have one, and she went to an ENT. She said they gave her prescriptions for Allegra and Singulair and then she went to the ENT for scheduled scratch allergy test they put her on Prednisone and took her off Allegra and Singulair. No further details provided about Prednisone. She said when she had the allergy test it came back that she was basically allergic to everything but cottonwood; a lot of foods and environmental that she didn't have prior allergies for in her life. She said the Allegra she is still taking, it is Allegra 180mg in the morning, and she is taking Singulair 10mg at bedtime, and taking Zyrtec 10mg over the counter in the middle of the day. She said she was taking two nasal sprays: Cromolyn 5.2mg spray and Flonase spray which is generic for Fluticasone propionate. She said she takes that during the night. Patient stated she never had any allergies, she always put down no known allergies to drugs or food, and now she is allergic to all. She says they tried 35-40 different things and nothing was severely react but all was reactive. When asked for seriousness, patient said significant, because it needed intervention because she needed four prescription medications. She says she hadn't mentioned the last, which she takes Benadryl if she wakes up in the middle of the night. She said not severe, but definitely a serious condition since it affects her daily life, she can't breathe. She says she just wanted it to be addressed and she hopes she can still have a few good years in her and wants to do what she can do with the stuffiness. She said she would like first of all to have her information documented, and second of all, wanted to see if Pfizer would recommend what to do. She said with all of the prescriptions she is on, her liver is not doing well, so she wants to get that under control, and get the amount of medications under control. She said maybe in the future someone will get to her incidence and see cases like hers and recommend something needs to be done. She said she was not asking for something, and they probably have data similar for this side effect, as it was obviously some kind of autoimmune response.  The information on the batch/lot number for BNT162b2 has been requested and will be submitted if and when received.; Sender's Comments: Based on the information currently available, a possible contributory role of the suspect drug to  all the reported events cannot be completely excluded based on temporal association and known drug safety profile The impact of this report on the benefit/risk profile of the Pfizer product is evaluated as part of Pfizer procedures for safety evaluation, including the review and analysis of aggregate data for adverse events. Any safety concern identified as part of this review, as well as any appropriate action in response, will be promptly notified to regulatory authorities, Ethics Committees, and Investigators, as appropriate