Age: 64.0
Sex: F
Vaccine: VARZOS
Symptoms: Arthritis, Condition aggravated, Dry skin, Musculoskeletal stiffness, Pain
Clinical narrative: She had stiff neck; It bleeds; very very itchy/ itchy back; Her lower back is weeps; lesions; itchy rash on lower back; Dry skin; Painful; pustules; when scratching it, it bleeds; crusted; Arthritis; This non-serious case was reported by a pharmacist via call center representative and described the occurrence of stiff neck in a 64-year-old female patient who received Herpes zoster (Shingrix) for prophylaxis.   The patient's past medical history included herpes simplex (had herpes simplex (cold sore) in the past and they used to occurred when she was out in the sun or sick), cold sores (had cold sore in the past was occurred when she was out in the sun or sick) and sickness. Previously administered products included Pneumococcal vaccine (received a pneumococcal vaccine in the past over a year ago and had no reaction). Concomitant products included aciclovir (Zovirax).   On 04-DEC-2023, the patient received the 1st dose of Shingrix (intramuscular, unknown arm). In DEC-2023, 1 week after receiving Shingrix, the patient experienced stiff neck (Verbatim: She had stiff neck), hemorrhage (Verbatim: It bleeds), pruritus (Verbatim: very very itchy/ itchy back), skin weeping (Verbatim: Her lower back is weeps), skin lesion (Verbatim: lesions), itchy rash (Verbatim: itchy rash on lower back), dry skin (Verbatim: Dry skin), pain (Verbatim: Painful), pustule (Verbatim: pustules), scratch (Verbatim: when scratching it, it bleeds), crust (Verbatim: crusted) and arthritis (Verbatim: Arthritis). The outcome of the stiff neck and skin lesion were not resolved and the outcome of the hemorrhage, pruritus, skin weeping, dry skin, pain, pustule, scratch, crust and arthritis were not reported and the outcome of the itchy rash was unknown.   It was unknown if the reporter considered the stiff neck, hemorrhage, pruritus, skin weeping, skin lesion, itchy rash, dry skin, pain, pustule, scratch, crust and arthritis to be related to Shingrix.     It was unknown if the company considered the stiff neck, hemorrhage, pruritus, skin weeping, skin lesion, itchy rash, dry skin, pain, pustule, scratch, crust and arthritis to be related to Shingrix.   Additional Information: GSK receipt date: 29-JAN-2024 and 30-JAN-2024 The patient stated that she had herpes simplex (cold sore) in the past but had not had an outbreak in a very long time and used to occur when she was out in the sun or sick and would take zovirax. The patient had 1st Shingrix vaccine and ended up with a reaction. The patient did not see that under any of the side effects, seem to weep and very very itchy only on my lower back. Upon callback to address medical information inquiry, pharmacist stated that the symptoms she experienced did not start immediately following vaccination.  Her symptoms started about a week later.  She was still having flare ups then they calm down and then start back up.  She went to a dermatologist, and they thought it was dry skin and prescribed triamcinolone.  At the time she did not even consider the fact she received Shingrix and then went to her doctor of medicine who suggested she get the lesions biopsied since it looked more like pustules.  She normally had very good smooth skin and never experienced this before. The flare up on her lower back was itchy and weeps. When scratching it, it bleeds.  The weepy lesions flare up went away then flare up then went away.  On 31st January 2024, she had an appointment with another dermatologist this week (Wednesday) and would ask if they would biopsy the lesion to verify if it was herpes zoster or another type of rash.  She stated that she was sometimes an over responder. She stated that when she was administered Shingrix it was painful.  She received it intramuscularly but was not sure which arm she received it in.  She also stated that she went to the doctor recently because her neck was killing her. She had stiff neck before but now it was severe but thought it might be arthritis; however, it was gotten really bad recently.  The reporter consented to follow-up.