Age: 56.0
Sex: M
Vaccine: VARZOS
Symptoms: Compartment syndrome, Fatigue, Induration, Injection site erythema, Injection site rash
Clinical narrative: Rash and swelling at the injection site; Rash and swelling at the injection site; little tired; bullseye rash on the injected arm; swelling; warm to touch; pain on mobility /pain; rock hard; erythema 12 inches long x 6 inches wide from above elbow up to supraclavicular; above elbow up to8 supraclavicular with pain and swelling; above elbow up to supraclavicular with pain and swelling; supraclavicular with pain and swelling; Impending Compartment Syndrome; This serious case was reported by a physician via call center representative and described the occurrence of compartment syndrome in a 56-year-old male patient who received Herpes zoster (Shingrix) for prophylaxis.   On 13-JAN-2024, the patient received the 2nd dose of Shingrix (left arm). On 14-JAN-2024, 1 days after receiving Shingrix, the patient experienced injection site rash (Verbatim: Rash and swelling at the injection site) and injection site swelling (Verbatim: Rash and swelling at the injection site). In JAN-2024, the patient experienced compartment syndrome (Verbatim: Impending Compartment Syndrome) (serious criteria GSK medically significant), tiredness (Verbatim: little tired), rash (Verbatim: bullseye rash on the injected arm), swelling arm (Verbatim: swelling), skin warm (Verbatim: warm to touch), pain in arm (Verbatim: pain on mobility /pain), induration (Verbatim: rock hard), erythema of extremities (Verbatim: erythema 12 inches long x 6 inches wide from above elbow up to supraclavicular), pain in elbow (Verbatim: above elbow up to8 supraclavicular with pain and swelling), swelling of elbows (Verbatim: above elbow up to supraclavicular with pain and swelling) and local swelling (Verbatim: supraclavicular with pain and swelling). The outcome of the compartment syndrome, injection site rash, injection site swelling, tiredness, rash, swelling arm, skin warm, pain in arm and induration were not resolved and the outcome of the erythema of extremities, pain in elbow, swelling of elbows and local swelling were not reported.   It was unknown if the reporter considered the compartment syndrome, injection site rash, injection site swelling, tiredness, rash, swelling arm, skin warm, pain in arm, induration, erythema of extremities, pain in elbow, swelling of elbows and local swelling to be related to Shingrix.     It was unknown if the company considered the compartment syndrome, injection site rash, injection site swelling, tiredness, rash, swelling arm, skin warm, pain in arm, induration, erythema of extremities, pain in elbow, swelling of elbows and local swelling to be related to Shingrix.   Additional Information: GSK Receipt Date: 16-JAN-2024, 17-JAN-2024 and 18-JAN-2024 The reporter was a patient. The reporter reported that he received the Shingrix vaccine and started having swelling and rash at the injection site 2 days ago from the reporting day. According to the reporter he had impending compartment syndrome. Doctor of medicine stated that he was a little tired but no fever, chills or malaise or anything like that. Reporter stated that he did had a temperature in the 99s and had the bullseye rash on the injected arm (left upper arm). Reporter stated that it was 3 days out and the rash was expanding. Reporter reported that the area was about 6 into 5 inches and started at the upper shoulder and goes down to mid arm. There was swelling warm to touch, had a pain on mobility, was rock hard and was concerned about compartment syndrome due to how hard the area was. Reporter mentioned that he would give himself a steroid injection. Upon call back to the reporter, he stated that the things had started to stabilize. The progression seems to had stopped. During conversation reporter mentioned that he had erythema 12 inches long into 6 inches wide from above elbow up to supraclavicular with pain and swelling in probably the node there that covers the area. The reporter did not consent to follow-up.