Age: 37.0
Sex: M
Vaccine: COVID19, COVID19, COVID19
Symptoms: Blood test, COVID-19 immunisation, Giant cell myocarditis, Immunisation reaction, Interchange of vaccine products
Clinical narrative: Syncopal episodes while exercising 6 and 10 weeks after last vaccine dose; Patient died on 19Jul2022. Autopsy showed granulomatous myocarditis; Multiple findings in other organs consistent with sarcoidosis.; This is a spontaneous report received from a contactable reporter(s) (Consumer or other non HCP). The reporter is the parent.  A 38-year-old male patient received BNT162b2 (BNT162B2), on 22Nov2021 as dose 3 (booster), single (Batch/Lot number: unknown) at the age of 37 years for covid-19 immunisation. The patient's relevant medical history included: "Mild hypertension" (unspecified if ongoing); "Asthma" (unspecified if ongoing). Patient had no known allergies. Concomitant medication(s) included: LISINOPRIL; MONTELUKAST; ZYRTEC [CETIRIZINE HYDROCHLORIDE]; PROVENTIL [SALBUTAMOL]. Vaccination history included: moderna coviD-19 (DOSE 2, SINGLE, lot number: 026L20A), administration date: 26Jan2021, when the patient was 36-year-old, for Covid-19 Immunization, reaction(s): "Had relatively severe reaction to all three doses"; moderna coviD-19 (DOSE 1, SINGLE, lot number: 039K20A), administration date: 29Dec2020, when the patient was 36-year-old, for Covid-19 Immunization, reaction(s): "Had relatively severe reaction to all three doses". Patient had no other vaccine in four weeks. The following information was reported: SARCOIDOSIS (death) with onset 19Jul2022 at 18:30, outcome "fatal", described as "Multiple findings in other organs consistent with sarcoidosis."; MYOCARDITIS (death) with onset 19Jul2022 at 18:30, outcome "fatal", described as "Patient died on 19Jul2022. Autopsy showed granulomatous myocarditis"; SYNCOPE (medically significant), outcome "unknown", described as "Syncopal episodes while exercising 6 and 10 weeks after last vaccine dose". The events "syncopal episodes while exercising 6 and 10 weeks after last vaccine dose" required physician office visit. Patient saw cardiologist who did ECG, Cardiac Echo, and Cardiac MRI. No treatment or further studies were recommended by cardiologist. Patient was advised follow up in 6 months. The patient underwent the following laboratory tests and procedures: Echocardiogram: (unspecified date) Unknown Results; Electrocardiogram: (unspecified date) Unknown Results; Magnetic resonance imaging heart: (unspecified date) Unknown Results; SARS-CoV-2 test: (20Jul2022) Negative, notes: Blood test, post mortem. Therapeutic measures were not taken as a result of myocarditis, sarcoidosis, syncope. The patient date of death was 19Jul2022. Reported cause of death: "Sudden adult death due to granulomatous myocarditis", "Multiple findings in other organs consistent with sarcoidosis.". The autopsy revealed "sudden adult death due to granulomatous myocarditis" (myocarditis); "multiple findings in other organs consistent with sarcoidosis." (sarcoidosis). The information on the batch/lot number for BNT162b2 has been requested and will be submitted if and when received.; Reported Cause(s) of Death: Sudden adult death due to granulomatous myocarditis; Multiple findings in other organs consistent with sarcoidosis.; Autopsy-determined Cause(s) of Death: Sudden adult death due to granulomatous myocarditis; Multiple findings in other organs consistent with sarcoidosis.