Age: 11.0
Sex: F
Vaccine: HPV4
Symptoms: Hypersomnia, Hypoacusis, Hypoaesthesia, Immunoglobulin therapy, Loss of personal independence in daily activities
Clinical narrative: sensitivy to light; trouble hearing; short term memory loss; dark circles under eyes; altered sense of taste; fever; Autoimmune Autonomic Neuropathy; Autoimmune Autonomic Neuropathy; Neurocardiogenic Syncope; Postural Orthostatic Tachycardia Syndrome; Orthostatic Hypotension; Dysautonomia; small fiber neuropathy; This initial spontaneous report was received from a lawyer regarding a case in litigation and refers to a 11 years old female patient. Information regarding the patient's medical history, concurrent conditions and concomitant medications was not provided.  On 25-SEP-2013, the patient was vaccinated with quadrivalent human papillomavirus (types 6,11,16,18) recomb. vaccine(GARDASIL)(strength, dose, frequancy, lot # and expiration date were not provided) for preventing cervical cáncer.  Two days after receiving the human papillomavirus (types 6,11,16,18) recomb. vaccine(GARDASIL) shot, the patient began to experience vomiting and headaches. One week later, on 03-OCT-2013, she began to experience severe body aches to go along with the vomiting and headaches from the week prior. She son(17-OCT-2013-18-OCT-2018) had fevers and began excessively sleeping, reporting extreme fatigue while awake. She was also dizzy, weak, and pale within a month after the shot she was bedridden, and wheel-chair bound if she had to be transported.   As weeks became months, the patient's symptoms and injuries continued to worsen, she was seen by multiple physicians and specialists to treat her growing list of symptoms, including daily migraines, severe body aches and pain, sensitive to light, dizziness and lightheadeness, nausea and fainting, pallor, dark circles under her eyes, constant abdominal pain, constant stomach upset, decreased appetite, severe joint muscle and bone pain, leg weakness, tingling, numbness, legs givin out, visión impairment and ocasional blurry visión , cognitive preocessing where she shouldbecome easily confused, problems with concentration, short memory los, chest pain, shortness of breath, occasional lower back pain, extreme fatigue, alterd sense of taste; pins and needles in the extremities, always feeling cold and having chills, low grade fevers, troble hearing and tinnitus, generalized weakness, becomen easily agitated and hipersomnia among other issues. With little to no relief from her symptoms, the patient was unable to engage in the activities she had enjoyed before receiving the vaccine.   From September 2016, the patient was tested with serum samples and the result was positive for the anti-beta 1 adrenergic antibodies, antimuscarinic cholinergic receptor 3, receptor 4 antibodies and an "at risk" result for anti beta 2 adrenergic antibodies. After undergoing testing to assess her post-Gardasil symptoms and adverse events, the patient was diagnosed with various medical conditions, including Neurocardiogenic Syncope (NCS), Postural Orthostatic Tachycardia (POTS), a form of Orthostatic Intolerance called Orthostatic Hypotension (OH), Small Fiber Neuropathy, and severe Autoimmune Autonomic Neuropathy.   At the time of the report the patient took 14 prescription medications. She also received a very expensive Intravenous Immune Globulin (IVIG) treatment at home every three weeks through a central line in her chest. If the IVIG treatment ceased to be administered at these regular intervals, she experienced a dramatic decline in her health to the point of becoming severely disabled again.  The reporter considered the aforementioned events to be related to human papillomavirus (types 6,11,16,18) recomb. vaccine(GARDASIL).  The reporter considered all the aforemntioned events to be disabling.  Upon internal review, the events of autonomic neuropathy, autoimmune neuropathy and Neurocardiogenic Syncope were considered to be medically significant.