Sex: F
Vaccine: COVID19
Symptoms: C-reactive protein, Chillblains, HLA marker study, Heart rate, Investigation
Clinical narrative: pernio-like lesions many months after being vaccinated/COVID Toes; This is a literature report.  A 56-year-old female patient received BNT162b2 (BNT162B2), as dose 2, single (Batch/Lot number: unknown) for covid-19 immunisation. The patient's relevant medical history included: "tobacco use disorder" (unspecified if ongoing); "hyperlipidemia" (unspecified if ongoing); "myocardial infarction" (unspecified if ongoing); "coronary artery disease" (unspecified if ongoing). The patient's concomitant medications were not reported. Vaccination history included: Bnt162b2 (DOSE 1, SINGLE), for covid-19 immunisation. The following information was reported: CHILLBLAINS (medically significant), outcome "recovered", described as "pernio-like lesions many months after being vaccinated/COVID Toes". The patient underwent the following laboratory tests and procedures: Ankle brachial index: normal, notes: Resting; normal, notes: exercise; Antineutrophil cytoplasmic antibody: negative; negative; Antinuclear antibody: negative; Auscultation: lungs were clear; unremarkable; Blood test: There was neither anemia nor leukocytosis; C-reactive protein: 21.4 mg/l, notes: Elevated; Heart rate: normal, notes: of the upper and lower extremities with absence of truncal rash, live doreticularis, and vesicular lesions; HLA marker study: negative; negative; heart tones: normal, notes: without murmurs, gallop rhythm, or rubs; unremarkable; physical examination: normal; Red blood cell sedimentation rate: negative; SARS-CoV-2 antibody test: 612.5, notes: elevated Unit- AU/ml; Vital signs measurement: normal. Therapeutic measures were taken as a result of chillblains.  Case report: The development of acral skin lesions resembling pernio was one example and was dubbed COVID toes in this patient population. The case of a COVID-19-vaccinated patient with a likely case of COVID-19 who developed pernio-like skin lesions that resolved after treatment with cilostazol. COVID-19, caused by the severe acute respiratory syndrome coronavirus2(SARS-CoV-2),has been associated with certain dermatologic manifestations. The development of acral skin lesions resembling pernio is one example,  and is dubbed COVID toes''in this patient population. We report the case of a COVID-19-vaccinated patient with a likely case of COVID-19 who developed pernio-like skin lesions that resolved after treatment with cilostazol.; Sender's Comments: Based on available information causal association between the reported event Chillblains cannot be totally excluded, the case will be reassessed once new information becomes available.   The impact of this report on the benefit/risk profile of the Pfizer drug is evaluated as part of Pfizer procedures for safety evaluation, including the review and analysis of aggregate data for adverse events. Any safety concern identified as part of this review, as well as any appropriate action in response, will be promptly notified to Regulatory Authorities, Ethics Committees, and Investigators, as appropriate.,Linked Report(s) : US-PFIZER INC-202300148229 Same article/patient/drug and different event;