Age: 54.0
Sex: M
Vaccine: COVID19, COVID19, COVID19, COVID19
Symptoms: Deep vein thrombosis, Headache, Hypertension, Laboratory test abnormal, Pain
Clinical narrative: BILATERAL CLOTS IN THE LEFT AND PROXIMAL MAIN PORTAL VEIN/ MULTIPLE BILATERAL CLOTS IN THE LUNGS; CLOTS IN SPLENIC VEIN; BOWEL LINING COMPROMISED BY THE BLOOD CLOT; BLEEDING (SLOUGHING OFF); MULTIPLE DVTS RIGHT LEG; MULTIPLE BILATERAL CLOTS IN LUNGS/ BILATERAL PULMONARY EMBOLISM; SMALL CLOTS WITHIN THE SMV (SUPERIOR MESENTERIC VEIN); ABDOMINAL MESENTERIC ISCHEMIA; PLATELET COUNT DECREASED 37 000; POST THROMBOTIC SYNDROME; BLOOD PRESSURE INCREASED; WEIGHT LOSS (15 LBS); CHILLS/ SHAKING; VOMITING/THREW UP; LETHARGIC; FELT SICK; FEVER OF 99.2; SEVERE HEADACHE; EXTREMELY TIRED; APPETITE IMPAIRED (NEVER ATE, COULD NOT KEEP ANYTHING DOWN); This spontaneous report received from a consumer concerned a 54 year old male. The patient's height, and weight were not reported. The patient's concurrent conditions included hypertension. The patient was previously treated with lisinopril for hypertension. The patient received covid-19 vaccine ad26.cov2.s (suspension for injection, route of admin not reported, batch number: 201A21A, expiry: unknown) dose was not reported, 1 total administered on 23-JUL-2021 for prophylactic vaccination. No concomitant medications were reported.  On 30-JUL-2021 around 05:30 a:m, the patient experienced severe shaking/chills, felt terrible and sick, vomiting/threw up, lower back pain, fever of 99.2 F, blood pressure increased, lethargic, severe headache, appetite impaired (never ate, could not keep anything down), extremely tired, felt sick. Laboratory data included: Blood pressure (NR: not provided) 170/110 mmHg. On 31-JUL-2021, the patient felt horrible and saw a teledoc. Teledoc said to get the antibodies done, Laboratory data included: COVID-19 virus test (NR: not provided) Negative, Antiphospholipid antibodies (NR: not provided) Positive. On 03-AUG-2021, the patient experienced platelet count decreased 37000 unspecified units.  On AUG-2021, the patient experienced post thrombotic syndrome. On 09-AUG-2021, the patient experienced abdominal mesenteric ischemia, multiple bilateral clots in lungs/ bilateral pulmonary embolism, small clots within the SMV (superior mesenteric vein), thrombosis pulmonary, severe abdominal pain and for that visited emergency department, flank pain, dry heaves in ICU (Intensive Care Units). The patient was hospitalized. On 10-AUG-2021, the patient experienced multiple deep vein thrombosis right leg and bleeding (sloughing off).  On 13-AUG-2021, the patient experienced bowel lining compromised by the blood clot. Would take 2-3 weeks to heal. Laboratory data included: Nuclear magnetic resonance imaging (NR: not provided) The bowel lining was compromised by the blood clot and was sloughing. On 16-AUG-2021, Laboratory data included: Computed tomography (CT) scan (NR: not provided) Various locations of clots as per report. His clots were still there but some had improved. On 17-AUG-2021, the patient experienced bilateral clots in the left and proximal main portal vein/ multiple bilateral clots in the lungs and clots in splenic vein.  On 19-AUG-2021, the patient experienced weight loss (15 lbs.). Laboratory data included: Platelet count (NR: not provided) 230, 000 unspecified units. Laboratory data (dates unspecified) included: Diagnostic ultrasound (NR: not provided) not reported, and X-ray (NR: not provided) unspecified. Other diagnostic data included PT and PTT. On 20-AUG-2021, the patient was still hospitalized. Blood pressure was still not under control and had fluctuated in hospital due to pain. At the time of report patient was on blood thinners which his wife indicated he would  likely be on for the rest of his life. He was being followed by hematology. The action taken with covid-19 vaccine ad26.cov2.s was not reported. The patient recovered from dry heaves in ICU, and chills/ shaking, and fever of 99.2 on 30-JUL-2021, was recovering from vomiting/threw up, feels terrible/felt horrible, lethargic, severe headache, flank pain, extremely tired, bowel lining compromised by the blood clot, small clots within the SMV (superior mesenteric vein), bilateral clots in the left and proximal main portal vein/ multiple bilateral clots in the lungs, clots in splenic vein, multiple bilateral clots in lungs/ bilateral pulmonary embolism, severe abdominal pain, low back pain, blood pressure increased, and platelet count decreased 37000, had not recovered from appetite impaired (never ate, could not keep anything down), multiple DVTS right leg, and felt sick, and the outcome of weight loss (15 lbs.), bleeding (sloughing off), post thrombotic syndrome and abdominal mesenteric ischemia was not reported. This report was serious (Hospitalization Caused / Prolonged).; Sender's Comments: V0: This spontaneous report received from a consumer concerned a 54-year-old man who experienced thrombocytopenia (day 11) and multiple sites of thrombosis in pulmonary, intra-abdominal, and peripheral sites (day 17) after vaccine. Medical history included hypertension treated with lisinopril. On day 7, the patient experienced severe shaking/chills, felt terrible and sick, vomiting, lower back pain, blood pressure increased, lethargic, severe headache, appetite, extremely tired.  On day 8: COVID-19 virus test Negative, Antiphospholipid antibodies Positive. On day 11, platelets were 37,000. On day 17, the patient experienced abdominal mesenteric ischemia, multiple bilateral pulmonary emboli, small clots within the SMV (superior mesenteric vein), thrombosis pulmonary, severe abdominal pain and was admitted to intensive care. On day 18, the patient experienced multiple deep vein thrombosis right leg and bleeding.  On day 21, the patient experienced bowel lining compromised by the blood clot with sloughing. On day 22, CT scan confirmed many clots. On day 23, the patient experienced bilateral clots in the left and proximal main portal vein/ multiple bilateral clots in the lungs and clots in splenic vein. On day 24, the patient experienced weight loss (15 lbs.). Laboratory data included: Platelet count improved to 230,000. On day 25, the patient was still hospitalized. Blood pressure was still not under control and had fluctuated in hospital due to pain. At the time of report patient was on blood thinners which his wife indicated he would likely be on for the rest of his life and he was being followed by hematology. Based on evolving knowledge of Thrombosis with Thrombocytopenia Syndrome (TTS, per definition from-BC), the low platelet count and temporal relationship to vaccination, the events are assessed to have a plausible relationship with vaccination. Additional information is requested.