Title: The biology of cancer /
Authors: Weinberg, Robert A. 1942-
Year: 2014
Subjects: Cancer Molecular aspects; Cancer Genetic aspects; Cancer cells; Cancer Aspect moléculaire.; Cancer Aspect génétique.; Cellules cancéreuses.; Cancer cells; Cancer Genetic aspects; Cancer Molecular aspects; Neoplasms genetics; Cell Transformation, Neoplastic; Genes, Neoplasm; Krebs.; Carcinogenese.; Maligne Transformation.
Abstract: Thoroughly updated and incorporating the most important advances in the fast-growing field of cancer biology, This book is a textbook for students studying the molecular and cellular bases of cancer at the undergraduate, graduate, and medical school levels. The principles of cancer biology are presented in an organized, cogent, and in-depth manner. The clarity of writing, supported by an extensive full-color art program and numerous pedagogical features, makes the book accessible and engaging. The information unfolds through the presentation of key experiments that give readers a sense of discovery and provide insights into the conceptual foundation underlying modern cancer biology. Besides its value as a textbook, this book is a useful reference for individuals working in biomedical laboratories and for clinical professionals. Every copy of the book comes with an updated DVD-ROM containing the book's art program, a selection of movies, audio file mini-lectures, Supplementary Sidebars, and a Media Guide.
Contents: The biology and genetics of cells and organisms -- The nature of cancer -- Tumor viruses -- Cellular oncogenes -- Growth factors, receptors, and cancer -- Cytoplasmic signaling circuitry programs many of the traits of cancer -- Tumor suppressor genes -- Prb and control of the cell cycle clock -- P53 and apoptosis: master guardian and executioner -- Eternal life : cell immortalization and tumorigenesis -- Multi-step tumorigenesis -- Maintenance of genomic integrity and the development of cancer -- Dialogue replaces monologue : heterotypic interactions and the biology of angiogenesis -- Moving out : invasion and metastasis -- Crowd control : tumor immunology and immunotherapy -- The rational treatment of cancer.