Title: The cholesterol wars : the skeptics vs. the preponderance of evidence /
Authors: Steinberg, Daniel, 1922-2015
Publisher: Elsevier Academic Press,
Year: 2007
Subjects: Atherosclerosis; Anticholesteremic agents; Statins (Cardiovascular agents); Cholesterol history; Atherosclerosis history; Hypercholesterolemia history; Hydroxymethylglutaryl-CoA Reductase Inhibitors history
Abstract: Today, in the era of the statins (cholesterol lowering drugs), there is no longer any doubt about the value of lowering blood cholesterol levels. This book chronicles the controversy that swirled around the 'lipid hypothesis' of atherosclerosis for so many years. In fact, 'the lower the better' is the position of many clinicians. However, getting to this point has been a long uphill battle marked by heated debate and sometimes violent disagreement. The history of this controversy is told here for its own sake and because remembering it may help us avoid similar mistakes in the future. * Dr. Steinberg and his colleagues have published over 400 papers relating to lipid and lipoprotein metabolism and atherosclerosis reflecting the prominence these authors have in the community. * Chronicles the miraculous power of the statins to prevent heart attacks and save lives, of great interest to the many manufacturers of these drugs * Discusses new targets for intervention based on a better understanding of the molecular basis of atherosclerosis.
Contents: Animal models of atherosclerosis -- Hypercholesterolemia and atherosclerosis in humans : casually related? -- Building the basic science foundation -- In search of a pathogenesis -- The seach for cholesterol-lowering drugs -- The 1984 coronary primary prevention trial -- Inhibition of cholesterol bio-synthesis, the discovery of the statins, and a revolution in preventive cardiology -- Summing up.