Title: Hypocretins : integrators of physiological functions /
Authors: Lecea, Luis de; Sutcliffe, J. Gregor 1948-
Publisher: Springer,
Year: 2005
Subjects: Orexins; Neuropeptides physiology; Orexins
Abstract: The hypocretins (orexins) are a newly identified (1998) peptide family comprised of two peptides, hypocretin-1 and hypocretin-2. Recent observations suggest an involvement of these peptides, located primarily in the hypothalmus, in the regulation of behavioral state. They are involved in circadian rhythms, metabolism, hormone secretion, body temperature, appetite, cardiovascular functions (e.g., blood pressure), and sleep abnormalities (e.g., narcolepsy and cataplexy).
Contents: Foreword -- Preface -- The Discovery Of The Hypocretins / L. de Lecea and J. G. Sutcliffe -- Orexin And Orexin Receptors / T. Sakurai -- Rodent Models Of Human Narcolepsy-Cataplexy / T. Sakurai, M. Mieda, M. Yanagisawa -- The Canine Model Of Narcolepsy / S. Nishino -- Anatomy Of The Hypocretin System / T. L. Steininger and T. S. Kilduff -- The Anatomy Of Hypocretin Neurons / T. L. Horvath -- Transmitter-Identified Neurons And Afferent Innervation Of The Lateral Hypothalamic Area / C. Broberger and T. Hökfelt -- Physiological Characteristics Of Hypocretin/Orexin Neurons / A. N. van den Pol -- The Ne System As A Target For Hypocretin Neurons: Implications For Regulation Of Arousal / G. Aston-Jones et al. -- Hypocretin/Orexin Actions On Mesopontine Cholinergic Systems Controling Behavioral State / C. S. Leonard et al. -- The Aminergic Systems And The Hypocretins / O. Selbach and H. L. Haas --^