Title: Emerging trends in antibacterial discovery : answering the call to arms /
Authors: Miller, Paul F.; Miller, Alita A.
Publisher: Caister Academic Press,
Year: 2011
Subjects: Antibacterial agents; Antibiosis.; Drug Discovery methods; Bacterial Infections drug therapy; Anti-Bacterial Agents
Contents: Answering the call to arms -- Answering the call to arms: introduction and overview -- Renewing investment in antibacterial research -- Novel targets and sources -- Mining bacterial cell division for new antibacterial drugs -- Efflux pumps from gram-negative bacteria: from structure and function to inhibition -- Metabolite-sensing riboswitches as antibacterial drug targets -- Targeting bacterial secretion systems for the development of novel therapeutic agents -- Recent developments in natural products: potential impact on antibacterial drug discovery -- Biosynthetic engineering of antibacterial natural products -- Microbial communities and interactions with the host -- Bacterial phenotypes refractory to antibiotic-mediated killing: mechanisms and mitigation -- Quorum-sensing inhibitors disable bacterial biofilms -- Indigenous human microbiota -- Prospects for the development of new anti-TB drugs based on novel targets related to the host-parasite relationship in tuberculosis -- Biological agents for antibacterial therapy -- Current strategies for antibacterial vaccine development -- Recent advances in vaccine adjuvants -- Host defence peptides -- Antibodies for antibacterials -- Therapeutic applications of phage biology: history, practice and recommendations -- Enabling antibacterial discovery -- Role of within-host models in target identification, compound optimization and dose selection -- Advances and applications in diagnostic microbiology and antibacterial discovery -- Changing the therapeutic paradigm in antibacterial drug therapy and discovery.