Title: Hereditary effects of radiation : UNSCEAR 2001 report to the General Assembly, with scientific annex /
Authors: United Nations.
Publisher: United Nations,
Year: 2001
Subjects: United Nations.; Radiation injuries; Radiogenetics; Radiation carcinogenesis Genetic aspects; Radiation Physiological effect; Radiation Effects; Radiation Genetics
Abstract: The United Nations Scientific Committee on the Effects of Atomic Radiation performed a comprehensive review of the hereditary risks to offspring following parental exposure to radiation. This report includes an evaluation of those diseases, which have both hereditary and environmental components, the so-called multifactor diseases. The information presented in this report suggests that radiation is less likely to have adverse genetic effects than had been assumed. This report provides a scientific basis for estimating radiation risk, establishing radiation protection and safety standards and regulating radiation sources for governments and organizations throughout the world.--Publisher's description.
Contents: Report of the United Nations Scientific Committee on the Effects of Atomic Radiation -- Scientific annex, "Hereditary effects of radiation". Introduction -- The human genome -- Mendelian diseases: Molecular nature of mutations ; Mutational specificities ; Genotype-phenotype relationships ; Baseline frequencies of Mendelian diseases ; Spontaneous mutation rates -- Multifactorial diseases: Congenital abnormalities ; Models of inheritance ; Common multifactorial diseases ; Mechanisms of maintenance of multifactorial traits in the population -- The mutation component for genetic diseases: Background ; Definition of mutation component ; Mutation component for autosomal dominant diseases -- Cancer predisposition, radiosensitivity, and the risk of radiation-induced cancers: Familial cancer genes ; Radiation sensitivity of cancer-predisposed individuals ; Computational modelling to estimate radiation risk in a heterogeneous population -- Other relevant studies: Human studies ; Animal studies ; Mosaic mutations and mutation clusters -- Concepts, data and analyses used for the estimation of genetic risks: Frequencies of genetic diseases in humans ; The doubling dose ; Mutation component ; The concept of potential recoverability correction factor ; Multisystem developmental abnormalities as manifestations of radiation-induced genetic damage in humans -- Risk estimates: Input parameter values ; Risk estimates ; Comparison of the present risk estimates with those of other approaches ; Genetic studies on survivors of the atomic bombings in Japan in the light of the present risk estimates -- Summary and conclusions.