Title: Quality of life : assessment, analysis, and interpretation /
Authors: Fayers, Peter M.; Machin, David, 1939-
Publisher: John Wiley,
Year: 2000
Subjects: Outcome Assessment, Health Care; Research Design; Quality of Life; Quality of life Research.; Outcome assessment (Medical care); Health Research Methodology.; Research Design.
Abstract: It is limited gains in survival or cure as an end result of the treatment of terminal illness that has led to an increasing interest in the importance of Quality of Life elements of clinical research.
Contents: Introduction. Introduction -- Principles of measurement scales. Developing and testing questionnaires. Scores and measurements: validity, reliability, sensitivity-- Multi-item scales -- Factor analysis -- Item response theory and differential item functioning -- Questionnaire development and scoring. Analysis of QoL data. Cross-sectional analysis -- Exploring longitudinal data -- Modelling longitudinal data -- Missing data -- Quality-adjusted survival. Practical aspects and clinical interpretation. Clinical trials -- Sample sizes -- Practical and reporting issues -- Clinical interpretation. Appendix: Examples of instruments. Generic instruments : Sickness Impact Profile (SIP) ; Nottingham Health Profile (NHP) ; Medical Outcomes Study 36-item short form-36 (SF-36) ; EuroQol (EQ-5D) ; Patient Generated Index (PGI) -- Disease-specific instruments : European Organization for Research and Treatment of Cancer (EORTC QLQ-C30) ; EORTC Head and Neck Module (EORTC H & N35) ; Functional Assessment of Cancer--General Version (FACT-G) ; Rotterdam Symptom Checklist (RSCL) ; Quality of Life in Epilepsy (QOLIE-89) ; Paediatric Asthma Quality of Life Questionnaire (PAQLQ) -- Domain-specific instruments : Hospital Anxiety and Depression Scale (HADS) ; Short Form McGill Pain Questionnaire (SF-MPQ) ; Multidimensional Fatigue Inventory (MFI-20) -- ADL and disability : Barthel Index of Disability (modified) (BI) -- Statistical tables : Normal distribution ; Probability points of Normal distribution ; The t-distribution ; The x² distribution ; The F-distribution.