Title: Emerging targets in antibacterial and antifungal chemotherapy /
Authors: Sutcliffe, Joyce A.; Georgopapadakou, Nafsika H., 1950-
Publisher: Chapman and Hall,
Year: 1992
Subjects: Antifungal Agents; Anti-Bacterial Agents; Pharmaceutical microbiology; Antibiotics; Microbial sensitivity tests; Microbiology; Drug Therapy
Contents: Machine derived contents note: Contributors; Preface; Part I: Antibacterial chemotherapy: Historical perspectives of approaches to antibiotics discovery Akira Imada and Kunimoto Hotta; Bacterial pathogens for the 90's: a case for new drug development George L. Drusano; DNA synthesis Charles S. McHenry; RNA synthesis in bacteria: mechanism and regulation of discrete biochemical events at initiation and termination Asis Das, Joseph DeVito, Jason Sparkowski and Frederick Warren; Bacterial cell division Joe Lutkenhaus; Fatty acid biosynthesis Suzanne Jackowski; Protein secretion in bacteria: a chemotherapeutic target? Rajeev Misra and Thomas J. Silhavy; Cytosolic enzymes in peptidoglycan biosynthesis as potential antibacterial targets W. Stephen Faraci; Strategies in Beta-lactam design Frank Neuhaus and Nafsika H. Georgopapadakou; Lipid A biosynthesis Jack Coleman; Compromising the protective barrier of the Gram-negative bacterial cell surface Catherine P. Reese and Joanna Clancy; Bacterial virulence factors as targets for chemotherapy Sarah H. Highlander and George M. Weinstock; Part II: Antifungal chemotherapy: Invasive fungal infections: problems and challenges for developing new antifungal compounds Thomas J. Walsh; Topoisomerase II inhibitors: prospects for new antifungal agents D.E. Jackson, D.P. Figgitt and S.P. Denyer; Functions for sterols in yeast membranes Leo W. Parks, R. Todd Lorenz and Warren M. Casey; Biochemical aspects of ergosterol biosynthesis inhibition Keith Barrett-Bee and Neil Ryder; Rationally designed inhibitors of sterol biosynthesis A.C. Oehlschlager and E. Czyzewska; Chitin synthase as a chemotherapeutic target Nafsika H. Georgopapadakou; Glucan biosynthesis in fungi and its inhibition Jan S. Tkacz; Virulence-associated mannoproteins in Candida albicans Richard A. Calderone and Makiko Fukayama; Screening for antifungal activity John F. Ryley and Keith J. Barrett-Bee; Chemotherapeutic targets in Pneumocystis carinii Gregg Y. Lipschik and Joseph A. Kovacs; Index.