Title: Applied biopharmaceutics & pharmacokinetics /
Authors: Shargel, Leon, 1941-; Yu, Andrew B. C., 1945-; Wu-Pong, Susanna.
Publisher: McGraw-Hill Medical,
Year: 2012
Subjects: Pharmacokinetics; Models, Chemical; Biopharmaceutics; Biopharmaceutics.; Pharmacokinetics.
Contents: Introduction to biopharmaceutics and pharmacokinetics -- Mathematic fundamentals in pharmacokinetics -- One-compartment open model: intravenous bolus administration -- Multicompartmental models : intravenous bolus administration -- Intravenous infusion -- Drug elimination and clearance -- Pharmacokinetics of oral absorption -- Multiple-dosage regimens -- Nonlinear pharmacokinetics -- Physiologic drug distribution and protein binding -- Drug elimination and hepatic clearance -- Pharmacogenetics -- Physiologic factors related to drug absorption -- Biopharmaceutic considerations in drug product design and in vitro drug product performance -- Drug product performance, in vivo : bioavailability and bioequivalence -- Impact of drug product quality and biopharmaceutics on clinical efficacy -- Modified-release drug products -- Targeted drug delivery systems and biotechnology products -- Relationship between pharmacokinetics and pharmacodynamics -- Application of pharmacokinetics to clinical situations -- Dosage adjustment in renal and hepatic disease -- Physiologic pharmacokinetic models, mean residence time, and statistical moment theory.