Title: Cardiac mechano-electric coupling and arrhythmias /
Authors: Kohl, Peter,; Sachs, Frederick.; Franz, M. R. 1949-; Kohl, Peter,
Publisher: Oxford University Press,
Year: 2011
Subjects: Heart Contraction; Arrhythmia.; Heart conduction system.; Biological control systems; Myocardium; Heart Conduction System physiopathology; Heart Conduction System physiology; Arrhythmias, Cardiac
Contents: Basic science, section I: sub-cellular mechanisms of cardiac mechano-electric coupling -- Evolutionary origins of stretch-activated ion channels -- Stretch-activated channels in the heart -- The mechano-gated K2P channel TREK-1 in the cardiovascular system -- Cell volume-sensitive ion channels and transporters in cardiac myocytes -- The response of cardiac muscle to stretch: calcium and force -- Stretch effects on second messengers -- Functional implications of myocyte architecture -- Mechanical modulation of pacemaker electrophysiology -- Mechano-electric coupling in working cardiomyocytes: diastolic and systolic effects -- Mechano-sensitivity of pulmonary vein cells: implications for atrial arrhythmogenesis -- Heterogeneity of sarcomere length and function as a cause of arrhythmogenic calcium waves -- Cellular mechanisms of arrhythmogenic cardiac alternans --^