Title: Neurons and the DHA principle /
Authors: Valentine, R. C. 1936-; Valentine, David L.
Publisher: CRC Press/Taylor & Francis Group,
Year: 2013
Subjects: Neurons metabolism; Cell Death; Alzheimer Disease etiology; Docosahexaenoic Acids metabolism; Docosahexaenoic acid Metabolism.; Neurons Metabolism.; Cell death
Contents: Nature of neurons and their specialized membranes -- DHA contributes both benefits and risks to mammals -- Use it or lose it concept of brain health is linked to DHA -- Evolution and DHA : redefining the DHA principle -- DHA is king omega for maximizing mental speed -- DHA improves energy efficiency in neurons -- Wild conformational dynamics of DHA might save energy by sealing stretch-induced defects as fast as they occur in membranes -- Lipid whisker model and water-wire theory of energy uncoupling in neurons -- Neurons boost their energy state by using powerful antioxidant systems to protect their membranes against damage -- Oxygen-dependent damage (lipid peroxidation) of DHA membranes of neurons is inevitable and requires novel mechanisms for long-term protection -- Revised mitochondrial theory of aging and brain span -- Development of dual energy pacemaker theory of aging : role of the membrane -- Membranes and cancer -- Parkinson's disease -- Prion diseases -- Brain trauma-induced dementia -- Alzheimer's disease.