Title: Genetic effects on environmental vulnerability to disease /
Authors: Rutter, Michael, 1933-; Novartis Foundation
Publisher: Wiley-Blackwell (an imprint of John Wiley & Sons Ltd),
Year: 2008
Subjects: Disease Susceptibility etiology; Genetic Predisposition to Disease genetics; Environmental Exposure adverse effects; Disease Susceptibility etiology.; Disease susceptibility Genetic aspects Congresses.; Environmentally induced diseases Genetic aspects Congresses.; Environmental Exposure adverse effects Congresses.; Genetic Predisposition to Disease genetics Congresses.
Abstract: "Genetic Effects on Environmental Vulnerability to Disease is based on the final meeting of the Novartis Foundation Symposium Series (#293 Understanding How Gene Environment Interactions Work to Predict Disorder). Interwoven with transcripts of the lively discussions among researchers, the book offers a cutting-edge review of the methodological issues prevailing in this complex, multi-disciplinary field. A glossary is included to facilitate inter-disciplinary understanding, and Sir Michael Rutter's introduction and concluding remarks contribute to presenting scientific issues in an interesting, easily accessible manner." "This book will be of interest to epidemiologists, geneticists, developmental biologists, and researchers in psychiatric disorders, obesity, diabetes, cancer, respiratory diseases and cardiovascular disease."--BOOK JACKET.
Contents: Introduction : whither gene-environment interactions? ? Michael Rutter -- Gene-environment interaction : overcoming methodological challenges / Rudolf Uher -- Gene-environment interaction and behavioral disorders : a developmental perspective based on endophenotypes / Marco Battaglia, Cecilia Marino, Michel Maziade, Massimo Molteni and Francesca D'Amato -- Use of monozygotic twins to investigate the relationship between 5HTTLPR genotype, depression and stressful life events : an application of item response theory / Naomi R. Wray, William L. Coventry, Michael R. James, Grant W. Montgomery, Lindon J. Eaves and Nicholas G. Martin.