Title: Structure and function in cell signalling /
Authors: Nelson, John, 1953 February 27-
Publisher: John Wiley & Sons,
Year: 2008
Subjects: Cellular signal transduction; Signal Transduction physiology; Amino Acid Sequence physiology; Intercellular Signaling Peptides and Proteins physiology; Intracellular Signaling Peptides and Proteins physiology
Abstract: This text is an introduction to the dynamic but complex field of signal transduction. Rather than simply cataloguing all signalling molecules and delineating every known pathway, this book aims to break signalling down into common elements and activities, the 'nuts and bolts' of cellular information exchange. It teaches the basic principles focusing on a mature core of knowledge, providing students with a foundation of learning in this complex and potentially confusing subject. It also addresses the issue of variation in the numbering of key amino acids as well as featuring interaction with RasMol software, and exercises to aid understanding.
Contents: Components and foundations of signalling -- Enzymes and receptors: quantitative aspects -- Modules and motifs in transduction -- Protein kinase enzymes: activation and auto-inhibition -- 7-pass receptors and the catabolic response -- Single pass growth factor receptors -- G-proteins (I): monomeric G proteins -- G proteins (II): heterotrimeric G proteins -- The insulin receptor and the anabolic response -- Mitogens and cell cycle progression.