Title: Computational biomedicine : modelling the human body /
Authors: Coveney, Peter; Díaz-Zuccarini, Vanessa, 1975- ,; Hunter, Peter, 1948-; Viceconti, Marco,
Year: 2014
Subjects: Models, Anatomic; Models, Biological; Computer Simulation; Biomedical Engineering; Computational Biology; Biomedical Technology; Medical technology; Biomedical engineering; Medical sciences Computer simulation.; Biological models Computer simulation.
Abstract: "By the end of the twenty-first century, computer-based modelling and simulation will be integral to the way clinical decisions are taken. Drugs will be selected on the basis of an individual patient's "digital profile", while clinical treatments will be tailor-made for the individual in question. For this to come to pass, however, we must prepare for a future where we can simulate our own bodies with precision, drawing upon remarkable advances in information technology, computer, mathematical, physical and engineering science, data management, and high performance computing. Computational Biomedicine lays the foundations for a new approach to the subject - one that unifies the different strands of a broad-ranging subject, and demonstrates how computational biomedicine is a powerful tool with the potential to revolutionise our understanding of the human body, and the therapeutic strategies available to maintain and protect it. Written by a team of world-leading experts in the field, it explores the modelling of physiological systems at different scales - cells, tissues, organs - before considering the issues around biomedical computing, and data collection and analysis. It emphasises how a theoretical understanding of computational biomedicine translates into practice, with illustrative examples and case studies used throughout. Computational Biomedicine is the perfect introduction to the subject for anyone new to the field, from student to researcher."--Publisher's website.
Contents: Machine generated contents note: 1.Introduction -- 1.1.Introduction -- 1.2.Systems Biology -- 1.3.Initiatives for Modelling Human Physiology -- 1.4.Book Synopsis -- References -- 2.Molecular Foundations of Computational Bioscience -- 2.1.Introduction -- 2.2.DNA and its Data Formats -- 2.3.RNA and its Data Formats -- 2.4.Proteins and their Data Formats -- 2.5.Metabolism, Metabolites, and their Databases -- 2.6.Integrating Different Data Types and Sources -- 2.7.Management of Omics Data Types -- Box 2.1 Example of the Use of Multiple Databases to Answer a Specific Research Question -- 2.8.Software Systems: Security and Interoperability -- 2.9.Conclusions -- Recommended Reading -- References -- 3.From Genotype to Phenotype -- 3.1.Introduction -- 3.2.Quantitative Genetics: A Brief Introduction -- 3.3.Systems Genetics -- Box 3.1 AcGP Model of the Action Potential of a Heart Muscle Cell --