Title: The hERG cardiac potassium channel : structure, function, and long QT syndrome /
Authors: Chadwick, Derek; Goode, Jamie; Novartis Foundation
Publisher: J. Wiley,
Year: 2005
Subjects: Heart physiology; Long QT Syndrome; Potassium Channels; Long QT Syndrome physiopathology; Potassium Channels, Voltage-Gated physiology; Potassium Channels, Voltage-Gated chemistry; Potassium Channels, Voltage-Gated physiology.; Potassium Channels, Voltage-Gated chemistry.; Long QT Syndrome.; Heart Pathophysiology Congresses.; Heart Physiology Congresses.; Long QT syndrome Congresses.; Potassium channels Congresses.
Abstract: This book draws together contributions from basic, pharmaceutical and clinical sciences and regulatory authority perspectives aimed at a better understanding of the structure and function of hERG, the molecular basis for compound binding and preferred preclinical test systems. Topics include hERG channel gating, regulation of functional expression, pharmacological properties of hERG/IKr channels, drug-induced long QT syndrome and preclinical evaluation and regulatory recommendations for assessing QT prolongation risks.
Contents: Gating and assembly of heteromeric hERG1a/1b channels underlying IKr in the heart / Gail A. Robertson, Eugenia M.C. Jones and Jinling Wang -- Structure-function studies of the outer mouth and voltage sensor domain of hERG / Gea-Ny Tseng and H. Robert Guy -- Voltage sensor movement in the hERG K channel / David R. Piper, Michael C. Sanguinetti and Martin Tristani-Firouzi -- hERG channel trafficking / Eckhard Ficker, Adrienne Dennis, Yuri Kuryshev, Barbara A. Wible and Arthur M. Brown -- Dynamic control of hERG/IKr by PKA-mediated interactions with 14-3-3 / Anna Kagan and Thomas V. McDonald -- Does hERG coassemble with a [beta] subunit? Evidence for roles of MinK and MiRP1 / Arun Anantharam and Geoffrey W. Abbott -- hERG block, QT liability and sudden cardiac death / Arthur M. Brown -- Structural determinants for high-affinity block of hERG potassium channels / John Mitcheson, Matthew Perry, Phillip Stansfeld, Michael C. Sanguinetti, Harry Witchel and Jules Hancox -- Physicochemical basis for binding and voltage-dependent block of hERG channels by structurally diverse drugs / Michael C. Sanguinetti, Jun Chen, David Fernandez, Kaichiro Kamiya, John Mitcheson and Još A. Sanchez-Chapula -- In silico modelling : pharmacophores and hERG channel models / Maurizio Recanatini, Andrea Cavalli and Matteo Masetti -- The long QT syndrome : a clinical counterpart of hERG mutations / Peter J. Schwartz -- Cellular mechanisms of Torsade de Pointes / Steven Poelzing and David S. Rosenbaum -- Expression and role of hERG channels in cancer cells / Annarosa Arcangeli -- TRIad, foundation for proarrhythmia (triangulation, reverse use dependence and instability) / Luc M. Hondeghem -- Drug-induced QT interval prolongation : regulatory guidance and perspectives on hERG channel studies / Rashmi R Shah.