Title: New targets in inflammation : inhibitors of COX-2 or adhesion molecules : proceedings of a conference held on April 15-16, 1996, in New Orleans, USA, supported by an educational grant from Boehringer Ingelheim /
Authors: Bazán, Nicolás G.; Botting, Jack H.; Vane, John R.; Bazán, Nicolás G.
Publisher: Kluwer Academic Publishers : William Harvey Press,
Year: 1996
Subjects: Inflammation Mediators; Cell Adhesion Molecules; Cyclooxygenase Inhibitors; Anti-Inflammatory Agents, Non-Steroidal; Inflammation Mediators.; Cell Adhesion Molecules.; Cell adhesion molecules Congresses.; Cyclooxygenases Inhibitors Congresses.; Inflammation Mediators Congresses; Nonsteroidal anti-inflammatory agents Congresses.; Anti-Inflammatory Agents, Non-Steroidal Congresses.; Cyclooxygenase Inhibitors Congresses.
Contents: The history of anti-inflammatory drugs and their mechanism of action / J.R. Vane -- Structure of prostaglandin H2 synthase-1 (COX-1) and its NSAID binding sites / P.J. Loll -- Differential inhibition of cyclooxygenases 1 and 2 by NSAIDs / M. Pairet -- Blockade of inflammatory hyperalgesia and cyclooxygenase-2 / S.H. Ferreira -- Brain COX-2 in experimental models of epilepsy and stroke: signalling pathways leading to enhanced expression / N.G. Bazan -- New highly selective cyclooxygenase-2 inhibitors / A.W. Ford-Hutchinson -- Characteristics of cyclooxygenase-1 and cyclooxygenase-2-deficient mice / S.G. Morham -- X-raycrystal structure of human cyclooxygenase-2 / M. Browner -- Risk of gastrointestinal side effects caused by non-steroid anti-inflammatory drugs (NSAIDs) / H. Jick -- Expression and regulation of cyclooxygenase-2 in synovial tissues of arthritic patients / L.J. Crofford -- Differential target tissue presentation and COX-1/COX-2 inhibitors by non-steroid anti-inflammatory drugs: a rationale for a new classification / H. Fenner -- Clinical experience with meloxicam, a selective COX-2 inhibitor / W. Bolten -- Enzymatic regulation of the prostaglandin response in a human model of inflammation / B.F. Adam -- Cyclooxygenase-2 and intestinal cancer / R.N. DuBois -- Cytokines and adhesion molecules in the lung inflammatory response / P.A. Ward -- Adhesion molecules as targets for therapy in rheumatoid arthritis / P.E. Lipsky.