Title: The molecular immunology of complex carbohydrates-3 /
Authors: Wu, Albert M.
Publisher: Springer Science+Business Media ,
Year: 2011
Subjects: Lectins; Glycoconjugates; Carbohydrates immunology; Carbohydrates Immunology Congresses.; Glycoproteins Immunology Congresses.; Glycolipids Immunology Congresses.; Lectins Immunology Congresses.; Glycoconjugates Immunology Congresses.
Abstract: "Based on the proceedings of the third international symposium on "Molecular Immunology of Complex Carbohydrates," this text is the latest in a series dedicated to glycotopes, structures and functions of complex carbohydrates, recognition factors of lectins, biomolecular interactions and other glycosciences. Section I of the book pays tribute to three pioneers in the field--Walter T.J. Morgan, Elvin A. Kabat and especially Winifred M. Watkins; it presents advanced concepts concerning the structure and functions of Blood group ABH/Le-related antigens, offering a comprehensive review on human blood group ABH/Ii, Lea, b, x, y and siayl Lea, x glycotopes of human ovarian cyst glycoproteins. Section II covers the interactions of plant, bacterial and animal lectins with carbohydrates and proteins. Section III describes the structures and functions of gangliosides and microbial glycolipids. Section IV covers the physiological roles of other clycocunjugates in humans, animals, sponges and bacteria as well as aging-related alterations of glycosylation profile in humans. Section V discusses the role of carbohydrates as antigens and regulators of the immune response. Section VI addresses some aspects of the glycobiology of cancer. And section VII details new methodologies in glycol-synthesis and lectin-carbohydrate binding assays and strategies for treatment as crucial applications."--Publisher's website.
Contents: pt. 1. Introduction to glyco-experiences. Serendipity in scientific discoveries: some examples in glycosciences / Yuan-Chuan Lee -- My 30-year devotion to the N-linked oligosaccharaide structures / Noriko Takahashi -- pt. 2. Blood group ABH/Le-related antigens. Human blood group ABH/Le, Le[a], [b], [x], [y], and Sialyl Le[a], [x] glycotopes: internal structures; and immunochemical roles of human ovarian cyst glycoproteins / Albert M. Wu -- Lewis glyco-epitopes: structures, biosynthesis, and function / Hui-Li Chen -- A unique endo-[Beta]-galactosidase that cleaves both blood group A and B glycotopes / Su-Chen Li, Kimberly M. Anderson, and Yu-Teh Li -- pt. 3. Lectins. Recognition roles of mammalian structural units and polyvalency in lectin-glycan interactions / Albert M. Wu [and others] -- Adhesian/growth-regulatory galectins: insights into their ligand selectivity using natural glycoproteins and glycotopes / Albert M. Wu [and others] --^