Title: Inborn errors of development : the molecular basis of clinical disorders of morphogenesis /
Authors: Epstein, Charles J.; Erickson, Robert P., 1939-; Wynshaw-Boris, Anthony Joseph.
Publisher: Oxford University Press,
Year: 2008
Subjects: Genetic disorders.; Developmental disabilities Genetic aspects.; Genetic disorders in children.; Developmental genetics.; Genetic Diseases, Inborn genetics; Congenital Abnormalities genetics; Human Development
Abstract: "The new edition of this book addresses the range of advances in the study of genetically caused abnormalities of human development. This edition features a wealth of color illustrations. The operating principle for organizing the clinical chapters remains one that is based on the notion of developmental pathways, analogous to the biochemical pathways that are involved in the inborn errors of metabolism." "This book will be a resource for physicians, dentists, genetic counselors, and other health professionals interested in going beyond clinical descriptions of multiple malformation syndromes to gain an understanding of their genetic basis and pathogenesis. It is also intended for the increasing number of basic scientists and students interested in developmental processes and in the human disorders that result from genetic perturbations that affect them."--BOOK JACKET.
Contents: I GENERAL CONCEPTS -- 1. Human Malformations and Their Genetic Basis / Charles J. Epstein -- 2. Principles of Differentiation and Morphogenesis / Scott F. Gilbert -- 3. Model Organisms in the Study of Development and Disease / Ethan Bier and William McGinnis -- 4. Consequences of the Genome Project for Understanding Development / Leena Peltonen -- II PATTERNS OF DEVELOPMENT -- 5. Developmental Origins of the Mammalian Body Plan / Angela J. Villar and Stephanie M. Ware -- 6. Neural Crest Formation and Craniofacial Development / Kurt A. Engleka, Deborah Lang, Christopher B. Brown, Nicole B. Antonucci, and Jonathan A. Epstein -- 7. Development of the Nervous System / John L.R. Rubenstein and Luis Puelles -- 8. Development of the Eye / Joe Rainger, Veronica van Heyningen, and David R. FitzPatrick -- 9. Development of the Ear / Donna M. Fekete -- 10. Molecular Regulation of Cardiogenesis / Vishal Nigam and Deepak Srivastava --^