Title: Hemophilia care in the new millennium /
Authors: Monroe, Dougald McDougald.; Roberts, H. R.
Publisher: Kluwer Academic/Plenum Publishers,
Year: 2001
Subjects: Hemophilia B; Hemophilia A; Hemophilia A therapy; Hemophilia Congresses
Abstract: These are the proceedings of the international symposium to honor Dr. Harold R. Roberts, held in Chapel Hill, North Carolina in April of 1999. These are the proceedings of the international symposium to honor Dr. Harold R. Roberts, held in Chapel Hill, North Carolina in April of 1999.
Contents: I. Infectious disease risk -- The transfusion-transmitted viruses in blood transfusion -- II. Unexplained aspects of hemophilia and hemostasis -- Are patients with glanzmann thrombasthenia and the Bernard-Soulier syndrome protected against atherosclerosis? -- Factor V: Dr. Jackyll and Mr. Hyde -- III. Novel approaches to therapy -- Gene therapy for hemophilia B: AAV-mediated transfer of the gene for coagulation factor IX to human muscle -- Use of prophylaxis to prevent complications of hemophilia -- Factor VIII inhibitors -- Use of high dose factor VIIa in hemophilia patients -- IV. Inhibitor development in hemophilia patients -- The incidence of inhibitors in hemophilia A and the induction of immune tolerance -- Mechanisms of B-cell tolerance -- Mechanisms of unresponsiveness: T- and B-cell mediated mechanisms of anergy -- CD4+ T cells specific for factor VIII as a target for specific suppression of inhibitor production -- CD4OL pathway blockade as an approach to immunotherapy -- Abstracts.