Title: Oral drug absorption : prediction and assessment /
Authors: Dressman, J. B.; Lennernäs, Hans.
Publisher: Marcel Dekker,
Year: 2000
Subjects: Pharmaceutical Preparations metabolism; Administration, Oral; Biological Availability; Solubility
Contents: I. Gastrointestinal variables -- Gastrointestinal transit and drug absorption -- Permeability in the gastrointestinal tract -- Gastrointestinal disease and dosage form performance -- II. Membrane permeability -- Intestinal permeability: prediction from theory -- In vitro methods for the assessment of permeability -- Animal perfusion studies -- Human perfusion studies -- The role of permeability studies in preclinical evaluation -- III. Solubility and drug dissolution -- Solubility as a limiting factor to drug absorption -- Dissolution testing of immediate-release products -- Dissolution testing in the development or oral drug products -- Analysis of drug dissolution data -- IV. In vivo-in vitro correlations -- Convolution and deconvolution methods -- The correlation of in vitro and in vivo drug dissolution -- IVIVC: a perspective from the workbench.