Title: Modern synthetic methods in carbohydrate chemistry : from monosaccharides to complex glycoconjugates /
Authors: Vidal, Sébastien,; Werz, Daniel B., 1975-; Werz, Daniel B., 1975-; Vidal, Sébastien,
Year: 2014
Subjects: Carbohydrates Synthesis.
Abstract: The fields of glycochemistry and glycoscience are rich and varied and where much can be learned from Nature. As Nature is not always able to produce carbohydrates in quantities useful for not only in research but also as therapeutic agents, new ways need to be found to optimize the yield. This book presents an overview of the latest developments in the field of carbohydrates, ranging from de-novo approaches via cyclodextrin chemistry to the synthesis of such highly complex glycoconjugates as glycosphingolipids and GPI anchors. The main emphasis remains on the synthetic aspects making the book an excellent source of information for those already involved in carbohydrate chemistry, as well as for those organic chemists who are beginners in this field. Equally of interest to synthetic chemists, as well as medicinal chemists and biochemists.
Contents: De Novo approaches to monosaccharides and complex glycans / Michael F. Cuccarese, Jiazhen J. Li, and George A. O'Doherty -- 2. Synthetic methodologies toward aldoheptoses and their applications to the synthesis of biochemical probes and LPS fragments -- 3. Protecting-group-free clycoconjugate synthesis: hydrazide and oxyamine derivatives in N-glycoside formation / Yoshiuyki A. Kwase, Melissa Cochran and Mark Nitz -- 4. Recent developments in the construction of cis-glycosidic linkages / Alphert E. Christina, Gijsbert A. van der Marel and Jeroen D.C. Codée -- 5. Stereocontrol of 1,2-cis-glycosylation by remote O-acyl protecting groups / Bozhena S. Komarova, Nadezhda E. Ustyuzhanina, Yury E. Tsvetkov and Nikolay E. Nifantiev -- 6. Synthesis of aminoglycosides / Yifat Berkov-Zrihen and Micha Fridman -- 7. Synthesis of natural and nonnatural heparin fragments: optimizations and applications toward modulation of FGF2-mediated FGFR signaling / Pierre-Alexandre Driguez -- 8. Light fluorous-tag-assisted synthesis of oligosaccharides / Rajarshi Roychoudhury and Nicola L.B. Pohl -- 9. Advances in cyclodextrin chemistry / Samuel Guieu and Matthieu Sollogoub -- 10. Design and synthesis of GM1 clycomimetics as cholera toxin ligands / José J. Feina and Anna Bernardi -- 11. Novel approaches to complex glycosphingolipids / Hiromune Ando, Rita Pal, Hideharu Ishida and Makoto Kiso -- 12. Chemical synthesis of GPI anchors and GPI-snvhotrf molecules / Ivan Vilotijevic, Sebastian Götze, Peter H. Seeberger and Daniel Varón Silva.