Title: Deoxynucleoside analogs in cancer therapy /
Authors: Peters, Godefridus Johannes, 1952-
Publisher: Humana Press,
Year: 2006
Subjects: Deoxyribonucleotides Therapeutic use.; Antineoplastic agents; Cancer Chemotherapy; Deoxyribonucleotides therapeutic use; Antineoplastic Agents therapeutic use; Neoplasms drug therapy
Contents: Ch. 1. Nucleoside Transport into Cells: The Role of Nucleoside Transporters SLC28 and SLC29 in Cancer Chemotherapy -- Ch. 2. The Role of Deoxycytidine Kinase in DNA Synthesis and Nucleoside Analog Activation -- Ch. 3. Deoxynucleoside Kinases and Their Potential Role in Deoxynucleoside Cytotoxicity -- Ch. 4. Nucleotidases and Nucleoside Analog Cytotoxicity -- Ch. 5. Pumping Out Drugs: The Potential Impact of ABC Transporters on Resistance to Base, Nucleoside, and Nucleotide Analogs -- Ch. 6. Cytosine Arabinoside: Metabolism, Mechanisms of Resistance, and Clinical Pharmacology -- Ch. 7. Clofarabine: Mechanisms of Action, Pharmacology, and Clinical Investigation -- Ch. 8. L-Nucleosides as Chemotherapeutic Agents -- Ch. 9. Troxacitabine: A Deoxycytidine Nucleoside Analogue With Potent Antitumor Activity -- Ch. 10. 9-[beta]-D-arabinofuranosylguanine -- Ch. 11. Gemcitabine: Mechanism of Action and Resistance -- Ch. 12. Clinical Activity of Gemcitabine as a Single Agent and in Combination -- Ch. 13. Nucleoside Radiosensitizers -- Ch. 14. NONMEM Population Models of Cytosine Arabinoside and Flubaradine Phosphate in Pediatric Patients with Leukemia -- Ch. 15. The cycloSal-Nucleotide Delivery System: Development of Chemical Trojan Horses as Antiviral Agents -- Ch. 16. Purine and Pyrimidine Based Analogs and Suicide Gene Therapy -- Ch. 17. 3'-deoxy-3'- Fluorothymidine as a Tracer if Proliferation in Positron Emission Tomography.