Title: Untangling the double helix : DNA entanglement and the action of the DNA topoisomerases /
Authors: Wang, James C.
Publisher: Cold Spring Harbor Laboratory Press,
Year: 2009
Subjects: DNA Topoisomerases; DNA topoisomerases Popular works.; DNA Topoisomerases.
Contents: An insuperable problem -- Nature's solutions: the DNA topoisomerases -- Breaking a DNA strand and holding onto -- The broken ends -- A magic swivel -- Moving one DNA double helix through another -- Real-time viewing of the DNA topoisomerases in action -- Manifestations of DNA entanglement: replication and recombination -- Manifestations of DNA entanglement: gene expression -- Beyond DNA untanglement: new twists on an old theme -- From nature's battlefields to the clinical wards -- Appendix 1: identification of the covalent intermediates in topoisomerase-catalyzed reactions -- Appendix 2: catalysis of DNA breakage and rejoining by DNA topoisomerases.