Title: Environmental chemicals, enzyme function, and human disease.
Authors: Evered, David.; Collins, Geralyn M.; Ciba Foundation.
Publisher: Excerpta medica ; Elsevier/North-Holland,
Year: 1980
Subjects: Enzymes metabolism; Pharmaceutical Preparations metabolism; Neoplasms etiology; Carcinogens, Environmental; Toxicology Congresses; Drugs Metabolism Congresses.; Enzyme induction Congresses.; Biotransformation (Metabolism) Congresses.
Contents: The role of the drug-metabolizing enzymes / James W. Bridges -- The influence of inducers on drug-metabolizing enzyme activity and on formation of reactive drug metabolites in the liver / Sten Orrenius, Hjordis Thor, Bengt Jernstrom -- Effects of inducers and inhibitors on drug-metabolizing enzymes and on drug toxicity in extrahepatic tissues / Michael R. Boyd -- Induction of enzymes involved in DNA repair and mutagenesis / B.A. Bridges -- Induction of drug-metabolizing enzymes by polycyclic aromatic hydrocarbons: mechanisms, and some implications in environmental health research / John R. Bend -- Induction of drug-metabolizing enzymes by phenobarbitone: structural and biochemical aspects / Urs A. Meyer, Peter J. Meier, Hans Hirsiger, Urs Giger, Felix R. Althaus -- Substrate-dependent irreversible inactivation of cytochrome P-450 : conversion of its haem moiety into modified porphyrins / Francesco De Matteis, Anthony H. Gibbs, Lavinia Cantoni, Jean Francis --^