Title: Pulmonary arterial hypertension : diagnosis and evidence-based treatment /
Authors: Barst, Robyn.; Barst, Robyn J. 1950-
Publisher: John Wiley & Sons,
Year: 2008
Subjects: Pulmonary Artery pathology; Evidence-Based Medicine methods; Hypertension, Pulmonary therapy; Hypertension, Pulmonary diagnosis; Pulmonary hypertension; Evidence-based medicine
Abstract: Pulmonary hypertension is frequently misdiagnosed and has often progressed to a late stage by the time it is accurately diagnosed. It has therefore long been considered untreatable and incurable with an overall very poor survival rate. However, new treatments are now available which have significantly improved prognosis. Recent data demonstrate survival is continuing to improve, with patients living for fifteen to twenty years or longer after diagnosis with an overall good quality of life. In this work, each chapter will discuss therapeutic options with reference to the pre-clinical studies which provided the rationale for their clinical development. The book also includes evidence-based treatment algorithms based on the 2007 update of the ACCP Guidelines for Medical Treatment of Pulmonary Hypertension.
Contents: Diagnosis and assessment of pulmonary arterial hypertension / Michael D. McGoon, Adam Torbicki, and Ronald J. Oudiz -- Conventional therapy in pulmonary arterial hypertension / Richard N. Channick -- Prostanoid treatment for pulmonary arterial hypertension / Olivier Sitbon and Gerald Simonneau -- Endothelin receptor antagonists in pulmonary arterial hypertension / David B. Badesch and Marc Humbert -- Phosphodiesterase-5 inhibitors in pulmonary arterial hypertension / Hossein A. Ghofrani, Werner Seeger, and Friedrich Grimminger --