Title: Targeted interference with signal transduction events /
Authors: Groner, B.
Publisher: Springer,
Year: 2007
Subjects: Signal Transduction physiology; Neoplasms physiopathology; Drug Delivery Systems; Cell Communication physiology; Neoplasms drug therapy; Cancer Chemotherapy; Cancer Gene therapy
Contents: Introduction: the rationale for the development of targeted drugs in cancer therapy -- Identifying critical signaling molecules for the treatment of cancer -- Tyrosine kinase inhibitors and cancer therapy -- Targeting ERBB receptors in cancer -- Inhibition of the IGF-I receptor for treatment of cancer. Kinase inhibitors and monoclonal anitbodies as alternative approaches -- Inhibition of the TGF-B signaling pathway in tumor cells -- The mammalian target of rapamycin kinase and tumor growth inhibtition -- The ras signalling pathway as a target in cancer therapy -- The mitogen-activated protein kinase pathway for molecular-targeted cancer treatment -- Clinical relevance of tareted interference with Src-mediated signal transduction events.