Title: Sepsis : new insights, new therapies.
Authors: Novartis Foundation.
Publisher: John Wiley & Sons,
Year: 2007
Subjects: Sepsis; Septicemia Congresses.; Sepsis Congresses.
Abstract: Brings together contributions from an international group of experts in diverse fields to consider how the various pathways implicated in early and late sepsis interact, with a particular emphasis on novel concepts and potential new therapeutic approaches. Topics covered include adaptive immunity, inflammation, neuroendocrinology, bioenergetics and metabolism. Several chapters in the latter half of the book are particularly concerned with treatment strategies involving modulation of the neuroendocrine response.
Contents: Strategies to modulate cellular energetic metabolism during sepsis / Alessandro Protti and Mervyn Singer -- Immunostimulation is a rational therapeutic strategy in sepsis / Jérôme Pugin -- Blockade of apoptosis as a rational therapeutic strategy for the treatment of sepsis / Alfred Ayala, Doreen E. Wesche-Soldato, Mario Perl, Joanne L. Lomas-Neira, Ryan Swan and Chun-Shiang Chung -- Modulating neutrophil apoptosis / John C. Marshall, Zeenat Malam and Songhui Jia -- HMGB1 as a potential therapeutic target / Haichao Wang, Wei Li, Richard Goldstein, Kevin J. Tracey and Andrew E. Sama -- Poly (ADP-ribose) polymerase activation and circulatory shock / Csaba Szabó -- Choosing the right substrate / Xavier Leverve, Cécile Batandier and Eric Fontaine -- Inhibiting glycogen synthase kinase 3[beta] in sepsis / Laura Dugo, Marika Collin, David A. Allen, Nimesh S.A. Patel, Inge Bauer, Eero M.A. Mervaala, Marjut Louhelainen, Simon J. Foster, Muhammad M. Yaqoob and Christoph Thiemermann -- Ethyl pyruvate, a novel treatment for sepsis / Mitchell P. Fink -- Cytoprotective and anti-inflammatory actions of carbon monoxide in organ injury and sepsis models / Stefan W. Ryter and Augustine M. K. Choi -- The hypothalamic pituitary adrenal axis in sepsis / Andrea Polito, Jérôme Aboab and Djillali Annane -- Modulating the endocrine response in sepsis : insulin and blood glucose control / Ilse Vanhorebeek, Lies Langouche and Greet Van den Berghe -- The neuronal strategy for inflammation / Luis Ulloa and Ping Wang -- Beta-blockade in burns / C.T. Pereira, M.G. Jeschke and D.N. Herndon -- System interactions / Mervyn Singer -- Protecting the permeability pore and mitochondrial biogenesis / C.A. Piantadosi, M.S. Carraway, D.W. Haden and H.B. Suliman.