tokens: We used stored plasma samples from 409 patients in the National Institute of Neurological Diseases and Stroke ( NINDS ) tissue plasminogen activator ( t - PA ) Stroke Trial to examine the relationship between an apolipoprotein ( Apo ) E2 or an Apo E4 phenotype and a favorable outcome 3 months after stroke , the risk of intracerebral hemorrhage , and the response to intravenous t - PA therapy .