tokens: In this series of studies , we sought to address the impact of depletion of the major effector lymphoid cell populations ( B220 + B cells , CD4 + or CD8 + T cells ) and key pro - inflammatory / Type 1 cytokines ( IFN - gamma or TNF - alpha ) on survival in BALB / c mice vaccinated with heat killed ( HK ) bacilli followed by an intraperitoneal ( i . p . ) challenge with live organism .