tokens: Three genes ( MAP2K1 , VEGF , PDGFA ) were altered two - fold or more after MUC1 siRNA in both MDA - MB - 468 and BT - 20 cells ( Figure 2 ) ; two genes ( ITGAV , MMP2 ) changed only in 468 . siMUC1 ; and five genes ( TIMP3 , RAF1 , JUN , TNF , CDC25A ) only in BT . siMUC1 .