tokens: However , it has been well documented that Rap1p and the other transcriptional regulators usually act at relatively short distances ( less than ~ 600 bp upstream of the translation start codon ) ( 28 , 29 , 46 ) , but the binding sites for these regulators were > 800 bp from the translation start codon in most of the silencing - blocking tests in this report ( Figs 1 and 2 ) .