tokens: The patients were divided into 3 subgroups : 1 ) 13 N + patients with multiple hot spots ( greater than 2 ) ( N + IM ) ; 2 ) 24 N + patients with single hot spots ( less than or equal to 2 ) ( N + IS ) ; 3 ) 12 N - patients with single hot spots ( less than or equal to 2 ) ( N - IS ) .