tokens: The observed phenotypes may be explained by ( i ) a selective disruption of very - low - density lipoprotein secretion due to decreased expression of genes encoding apolipoprotein B and microsomal triglyceride transfer protein , ( ii ) an increase in hepatic cholesterol uptake due to increased expression of the major high - density lipoprotein receptor , scavenger receptor BI , and ( iii ) a decrease in bile acid uptake to the liver due to down - regulation of the major basolateral bile acid transporters sodium taurocholate cotransporter protein and organic anion transporter protein 1 .