\begin{table}
\centering
\caption{Donor and Recipient Demographics}
\label{table_1}
\begin{tabular}{llll}
Variable & CDCHR (n=50) & Non-HR (n=125) & P Value \\
\hline
Donors & & & \\
Demographics & & & \\
Age, mean (SD), y & 35 (11) & 43 (18) & .01 \\
Female sex, \% & 34.0 & 46.4 & .10 \\
BMI, mean (SD) & 25.2 (4.1) & 26.9 (6.8) & .10 \\
Race/Ethnicity, \% & & & .60 \\
\quad White & 74.0 & 67.2 & \\
\quad Black & 16.0 & 22.4 & \\
\quad Other & 10.0 & 10.4 & \\
Cause of death, \% & & & .20 \\
\quad Head trauma & 36.0 & 28.8 & \\
\quad Anoxia & 34.0 & 24.8 & \\
\quad Cerebrovascular accident & 30.0 & 44.8 & \\
\quad Other & 0.0 & 1.6 & \\
Share type, \% & & & .005 \\
\quad Local & 22.0 & 47.2 & \\
\quad Regional & 4.0 & 5.6 & \\
\quad National & 74.0 & 47.2 & \\
Cold ischemia time, mean (SD), h & 25.5 (12.0) & 21.9 (12.7) & .10 \\
Expanded criteria donor, \% & 2.0 & 24.8 & $<$.001 \\
Donor after cardiac death, \% & 10.0 & 20.0 & .10 \\
HBV core antibody positive, \% & 16.7 & 9.6 & .20 \\
HCV positive, \% & 18.0 & 7.2 & .03 \\
Terminal creatinine level & & & \\
\quad Median (range), mg/dL & 0.9 (0.8-1.1) & 0.9 (0.6-1.2) & .50 \\
\quad $>$2.5 mg/dL, \% & 4.0 & 8.8 & .002 \\
Recipients & & & \\
Demographics & & & \\
Age, mean (SD), y & 60 (12) & 56 (13) & .02 \\
Female sex, \% & 34.0 & 37.6 & .70 \\
Race/Ethnicity, \% & & & $>$.99 \\
\quad White & 38.0 & 40.0 & \\
\quad Black & 54.0 & 52.0 & \\
\quad Other & 8.0 & 8.0 & \\
ABO blood group, \% & & & .80 \\
\quad A & 36.0 & 36.0 & \\
\quad B & 14.0 & 19.2 & \\
\quad O & 40.0 & 40.0 & \\
\quad AB & 10.0 & 4.8 & \\
Diabetes mellitus, \% & 34.0 & 29.6 & .10 \\
BMI, mean (SD) & 29.0 (5.0) & 27.3 (5.2) & .04 \\
Peak panel reactive antibody, mean (SD), \% & 12.3 (30.3) & 16.1 (31.3) & .50 \\
Previous kidney transplantation, \% & 10.0 & 9.6 & .90 \\
Preemptive kidney transplantation, \% & 25.0 & 13.7 & .10 \\
HCV positive, \% & 21.3 & 11.2 & .10 \\
HIV positive, \% & 8.0 & 0.0 & .001 \\
Waiting list time, median (range), d & 274 (11-1855) & 736 (325-1806) & $<$.001 \\
\end{tabular}
\end{table}

Abbreviations: BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); CDCHR, Centers for Disease Control and Prevention high risk; HBV, hepatitis B virus; HCV, hepatitis C virus; HIV, human immunodeficiency virus; Non-HR, non–high risk.

SI conversion factor: To convert creatinine to micromoles per liter, multiply by 88.4.

\begin{figure}
\centering
\includegraphics{figure_1.pdf}
\caption{High-risk behaviors among donors. CSW indicates career sex worker; IVDA, intravenous drug abuse; and MSM, men who have had sex with men.}
\label{figure_1}
\end{figure}

donors (44.8\%). Most CDCHR donors were imported through national OPO sharing (74.0\% vs 47.2\% of non-HR donors, P=.005). Because our center routinely imports non-HR donor kidneys with lengthy cold ischemia times, the mean (SD) cold ischemia times were not significantly different between cohorts (25.5 [12.0] vs 21.9 [12.7] hours, P=.1), despite a higher percentage of nationally imported kidneys in the CDCHR group. The proportion of donors after cardiac death tended to be greater among non-HR donors (20.0\% vs 10.0\% of CDCHR donors, P=.1), and the proportion of expanded criteria donors was significantly greater among non-HR donors (24.8\% vs 2.0\% of CDCHR donors, P$<$.001).

All donors tested negative for HIV by NAT. Among CDCHR donors, 18.0\% were HCV positive compared with 7.2\% of non-HR donors (P=.03) (Table~\ref{table_1}). All HCV-positive organs were transplanted into HCV-positive recipients who specifically gave consent to accept an HCV-positive kidney. Among CDCHR donors, 16.7\% were HBV core antibody positive compared with 9.6\% of non-HR donors (P=.2). All recipients of kidneys from HBV core antibody–positive donors specifically consented to accept these organs. Overall, the median terminal creatinine level did not differ between CDCHR and non-HR donors (0.9 mg/dL for both groups) (to convert creatinine to micromoles per liter, multiply by 88.4). However, a greater proportion of non-HR donors had a high terminal creatinine level exceeding 2.5 mg/dL (8.8\% vs 4.0\% of CDCHR donors, P=.002).

The distribution of high-risk behaviors among CDCHR donors is shown in Figure~\ref{figure_1}. Intravenous drug abuse was the most common high-risk behavior among these donors and was reported in 26 of 50 donors. Thirteen donors were inmates of correctional facilities at the time of death, 10 had a history of having had sex with a high-risk partner, 6 were career sex workers, 3 were men with a history of having had sex with other men, 1 was characterized as high risk for a history of massive transfusion and hemodilution at the time of death and at the time of NAT, and 1 was characterized as high risk be-