Is Ciliopathy as a genetypic cause of phenotypical obesity worth mentioning in the article A few edits ago I added a single sentence to the obesity article Obesity is one symptom reported in a newly discovered class of genetic diseases known as ciliopathies which I sourced from this journal article My edit was removed perhaps because I wrote poorly What I was trying to say is that there is now as of some fairly recent developments in the genetics literature at least a plausible hypothesis that one potential cause underlying molecular cause or underlying genetic cause for some particular cases of clinically observed obesities is ciliopathy Perhaps my use of the word symptom was a mistake but I thought that saying one potential genotype for the obesity phenotype is ciliopathy to be rather too esoteric Perhaps the entire sentence needs to be rewritten But I do think it is an appropriate addition to the Obesity article I am in no way saying that all ciliopathies result in obesity They obviously do not From the last ten years of work in molecular genetics with animals that have the cilia organelle one thing that is obvious is that ciliopathies manifest in an extremely pleiotropic manner But there is a plausible hypothesis that has been put forward in the academic literature relating to a ciliopathic underlying cause for some clinically observed obesities it has to do with a dysfunction in the molecular signaling pathway along the cilia and or basal bodies that signals fullness and or taste and or time to move food onward in the large and or small bowell etc To date most of the specific ciliopathic genes that have been related to obesity have been studied only in relation to more pleiotropic genetic syndromes such as Alstrom s MKKS and BBS But the ciliopathic root cause identified in some and implied in others is encyclopedically interesting In my view this newly discovered connection is worthy of mention in the obesity article But I am not well read on Obesity so I will let those editors who frequent this article hash it out Cheers