Cryotherapy may not SEEM to be as effective as it might be because of the way different clinicians apply it A liquid nitrogen cold burn which goes sufficiently deep enough to kill all the infected cells is very painful akin to a cigarette burn When a doctor applied this technique to a wart on my hand the surface layers of the wart did die off and flake away after a few days but the wart recurred in a couple of months I found by treating myself that a very painful burn with repeat applications of liquid nitrogen on one occassion seemed to get rid of the wart permanently It could be that doctors are being too gentle