non - small cell lung cancer ( nsclc ) can exhibit rearranged driver oncogenes , which are possible targets for therapy.1 the most frequently identified driver oncogenes in nsclc leading to targeted therapy are epidermal growth factor receptor ( egfr ) and anaplastic lymphoma kinase ( alk).1,2 the prevalence of these driver oncogenes is significantly influenced by race , smoking habits , and gender.3 the frequency of egfr - mutated nsclc in asian patients is known to be higher than in caucasian patients.3 in contrast , prevalence of alk rearrangements in nsclc is reported to be similar in caucasian and asian patients.3 in recent cohort studies with afro - americans , there is no significant difference in the prevalence of egfr mutations or alk rearrangements with caucasian americans.4,5 about other races , however , less or no data are available.6,7 for obvious reasons , little is known about africa . cancer , however , is a significant health problem in this continent , as it is estimated that there were 715,000 new cancer cases in 2008 , and additional data from southern africa and northern africa already confirm that lung cancer is the leading cause of death related to cancer.8 to our knowledge , there is no literature available about the prevalence of lung cancer and rearranged driver oncogenes in sub - saharan africans . as the latter is influenced by race and smoking habits that may differ from afro - americans ; we have studied the prevalence of egfr mutations and alk translocations in a case series of patients of sub - saharan african ethnicity with nsclc . we retrospectively studied all patients of sub saharan african ethnicity who have been treated for nsclc stage iv in our hospital ( university hospital saint pierre ) in brussels , belgium . the ethics committee of saint - pierre hospital deemed ethical approval not necessary as it was a retrospective study . investigations were performed on biopsies obtained during flexible bronchoscopy and these samplings were immediately fixed in neutral buffered formalin and embedded in paraffin.9 driver oncogenes on biopsy specimens were researched by using the truseq amplicon cancer panel ( illumina , illumina inc . , san diego , ca , usa ) . not only were egfr / alk mutations investigated , but also other mutations included in the panel , such as tumor protein p53 ( tp53 ) , proto - oncogene b - raf ( braf ) and kirsten rat sarcoma viral oncogene homolog ( kras ) . from july 2012 to november 2015 , 6 patients of sub - saharan origin with nsclc stage iv have been treated in our hospital . three patients originated from congo , an ex - belgian colony , 1 from djibouti , lfrom cameroon , and 1 from guinea . egfr mutation was present in 3/6 patients and alk rearrangement was present in 1/6 patients . two egfr mutations were common , i.e. , l858r ( exon 21 point mutation ) and deletion exon 19.10 the significance of the third egfr mutation ( t710i in exon 18 ) is unknown . all egfr mutations and both patients without egfr mutation and alk rearrangement were considered as light smokers ( < 10 pack - years ) . in our small case series , 4 out of 6 sub - saharan patients with nsclc had a driver oncogene , either egfr mutation or alk rearrangement . the prevalence of rearranged driver oncogenes in nsclc is known to be influenced by race , gender , and smoking status.3 differences in prevalence of egfr mutation status in nsclc between asian and caucasian patients have already been extensively studied since the early 2000s.2,3 egfr mutations ( exons 1822 ) are present in ~30% east asian patients with lung cancer , and more specifically in 35%47% of east asian patients with lung adenocarcinoma , whereas egfr mutations are present in ~7% of caucasian patients with lung cancer , and in 13%18% of caucasian patients with lung adenocarci - noma.3,4 even within the asian population , egfr mutation status in nsclc varies.6 the east asian population is the largest asian group studied ( japanese , korean , and chinese patients).3,4,6 in a large cohort of 907 indian patients , an egfr mutation was found in 23% of patients with nsclc and in 26% of lung adenocarcinomas.6 recently , egfr mutations in nsclc in afro - american patients have been investigated.4,5,11 there seems to be no difference in prevalence of egfr mutations in ncslc between caucasians and afro - americans . yamaguchi et al described a prevalence of egfr mutations in nsclc of 18.4% in white patients and in 18.2% of black patients in their patient cohort.4 bollig - fischer et al found a prevalence of 8% of egfr mutations in both black and white patients with nsclc.11 it is not clear whether these results for afro - american patients can be extrapolated to sub - saharan african patients with nsclc . errihani et al performed the only study , to our knowledge , on the prevalence of egfr mutation status in lung cancer patients in the african continent.7 they examined in a moroccan patient cohort the prevalence of egfr mutations in advanced lung adenocarcinoma . a prevalence of 21% egfr mutations in lung adenocarcinoma was found ( 29 out of 137 patients ) , which lies between the prevalence of egfr mutations in caucasian and asian patients with nsclc.7 it is unclear whether the results of the moroccan ( north african ) cohort also apply to sub saharan african patients with nsclc . besides race , the presence of driver oncogenes is influenced by gender and smoking history.3 in this limited series , the role of gender was impossible to assess . finally , smoking status independently influences egfr mutation status in nsclc.2,3,4 the prevalence is higher in never smokers or light smokers . in our study , 3 out of 6 patients had an egfr mutation . this incidence seems high , but interestingly , all our 6 patients were non - smokers or light smokers . in europe , the prevalence of tobacco use among adults is approximately 19% for women and 38% for men.12 in the african continent , at first sight , smoking prevalence does not seem to be different , as among males it ranges from 14% in swaziland to 40% in niger.13 however , according to a recent analysis of the american cancer society , most african countries remain in the early stages of the tobacco epidemic , with tobacco use relatively low compared to the rest of the world.14 on this basis , it is likely that the proportion of lung adenocarcinoma in non - smokers is still high and this may contribute to explaining the frequent egfr mutations in our case series . indeed , egfr mutations in nsclc have been found in 35%40% of caucasian never smokers , and in 55%70% of asian never smokers.3,4 we believe this explanation also applies for the finding of one alk translocation in our small series . the overall prevalence of alk translocation in nsclc is thought to be 3%5% , without ethnic difference , but with a higher prevalence in non - smokers.3,4 even if these results can not be extrapolated due to the small number of patients , the early stages of the tobacco epidemic in africa are probably associated with a high frequency of egfr mutation and alk rearrangement in nsclc . this will probably change with time , as africa is becoming a future epicenter of tobacco epidemic.13 in this small series , 4/6 patients of sub - saharan origin with nsclc presented driver oncogene rearrangements . this may be related to the fact that africa is still in the early stages of the tobacco epidemic , leading to suggest that the prevalence of driver oncogenes is high in this population . as the burden of lung cancer in sub - saharan countries is expected to rise in the next decennia,8 further investigations of nsclc subgroups in this racial group are required .
non - small cell lung cancer can exhibit driver oncogenes , including epidermal growth factor receptor ( egfr ) and anaplastic lymphoma kinase ( alk ) , that are possible targets for therapy . 
 the prevalence of these rearranged driver oncogenes is influenced by race , smoking habits , and gender . 
 most data come from caucasian and asian populations . to our knowledge 
 , there is no literature available about the prevalence of driver oncogenes in sub - saharan africa , where the tobacco epidemic is still in the early stage . in this small case series , 6 patients of sub - saharan african ethnicity with stage iv lung adenocarcinoma are described . 
 egfr mutation was present in 3/6 patients and alk rearrangement in 1/6 patients . 
 this incidence seems high but interestingly , all patients were non - smokers or light smokers . in this series , 
 the high prevalence of driver oncogene was probably related to low smoking habits and these initial data in sub - saharan africans suggest high prevalence of driver mutations for this reason .