hepatitis c virus ( hcv ) is a major public health problem all over the world ; it is currently estimated that about 85% of those infected with hepatitis c virus will become a chronic carrier and may develop severe end stage liver diseases including cirrhosis and hepatocellular carcinoma . currently , the most important risk factor for infecting by hepatitis c is intravenous drug use ( idu ) which is the most associated with the sharing of drug injection equipments especially needles , syringes and other paraphernalia . infection with hcv among prison inmates is usually higher than that among the general population mainly because of past history of intravenous drug use and possibly high risk addiction - related behaviors in prison . during the last few years , much attention has been given to the prevalence of blood born diseases including hepatitis c among prisoners . according to limited research studies in iran , prevalence of hcv infection among prisoners with a history of drug injecting varies between 31.5% to 47% in different parts of the country.[68 ] however , a study in a local prison in fars province revealed 78% prevalence rates of hcv infection among incarcerated drug users . to address the often hidden phenomenon of hcv infection in prisons , considering the limited data on the epidemiology of hcv infection and related risk behaviors in our region , in this study we have focused on this infection and transmission risk factors among prisoners with history of idu in isfahan that could potentially be incorporated into current and future harm reduction initiatives us in iran . in a cross - sectional study , according to self - report and confirm by head of prison 's healthcare , the prison inmates who had intravenous drug history or current idus entered into study at march 2009 . since the most of our enrollees had sclerosis in peripheral vessels , blood sampling was mostly taken from the femoral vein by the health personnel of the prison setting . blood samples were then sent to the laboratory of infectious diseases research center during 3 hours in cold box to be tested by eilsa ( diapro - italy ) for the presence of hcv antibody . incarcerated with idu histories were also asked about their demographic characteristics and hcv - related risk behaviors with an interviewer assisted questionnaire . face and content validity of the questionnaire were evaluated by specialists and its reliability was confirmed by chronbach alpha = 0.74 . the research protocol was approved by the ethical committee of isfahan university of medical sciences in iran . all available means were used to guarantee privacy during interviews and confidentiality . instead of a block for the patient 's name , each questionnaire and test tube had an anonymous identification code , which was used for reporting laboratory results , too . statistical analysis was performed using spss for windows ( version 16.0 , 2007 , spss inc , chicago , il , usa ) . univariate analysis was used to assess association between being hcv positive and related risk factors . the variables that were significant in the univariate analysis ( p - value < 0.05 ) were included in the multiple logistic regression to estimate adjusted odds ratio ( aor ) and 95% confidence intervals ( ci ) . a total of 943 incarcerated idus ( 938 male and 5 female ) participated in the study . the median age of participants was 32.6 years ( range : 18 - 67 ) . the majority of participants ( 98.6% ) were iranian and 523 ( 55.5% ) had ever been married . among the married persons 451 ( 92% ) had been married once , 35 ( 7% ) had been married twice and 5 ( 1% ) had been married more . 143 ( 15.1% ) cases mentioned a history of traveling to another countries . the socio - demographic characteristics of participants overall , the prevalence of hcv - ab seropositivity was 41.6% [ table 1 ] . the median frequency of iv injections was 30 times per month ( range 1500 ) , the median duration of addiction was 12 years ( range 0.5 - 57 ) , the median frequency of incarceration was 3 times ( range 1 - 37 ) , and the median of total duration of incarceration was 3.66 years ( range 0.08 - 35 ) . frequency of hcv transmission related factors within study population 71.76% of the participants had illegal sex ( contact with other than spouse ) . among whom , 43% of men had history of having sex with another man ( msm ) , 64.2% had an intercourse with commercial sex workers and 30.9% of them had idu sexual partner . according to self reports , only 31% of them had ever used a condom during sex . within all studied samples with idu history , 13.3% had a single sexual partner and the others had 2 or more , in their lifetime . table 3 shows the odds ratio for some risk characteristics of idus using the logistic regression model . the results of this study indicated that overall prevalence of hcv ab seropositivity among idu inmates in isfahan province is 41.6% . in similar studies in iran , similar results were observed . in zakizad study , the seroprevalence of hepatitis c infection in sari addict prisoners has been reported as 30.8% . in another study by khani et al . the prevalence of hcv was 47.7% among drug addict prisoners in zanjan . in a study which was done in 3 provinces in iran ( isfahan , chahamahal bakhtiary and lorestan ) in 2003 , 34.7% of male prisoners who had been imprisoned for various drug - related offenses including purchase or sale and consumption , were hcv ab positive . in mashhad , the seroprevalence of hcv in incarcerated idus had been reported as 59.4% . in mohammad alizadeh study , the hcv antibody positivity among drug abusers in the central prison of hamedan was 30% . in a study on drug abusers admitted to prison in guilan province , of 460 inmates , 45.4% were hcv antibody positive which in intravenous drug abusers the prevalence reached to 88.9% . the prominent aspect of our study in comparison with other similar studies in iran , is the high number of participants whom all of them had history of intravenous addiction . as a matter of fact , this is one of the first large prevalence studies of blood- born infections among incarcerated idus in iran . in this study , the history of shared drug injection inside prison was one of the main incarceration - related risk factors . this association , has also been reported in other studies in the world.[1315 ] it seems that , the lack of access new needle / syringe in prisons and consequently needle sharing practice is the main reason of the hepatitis c epidemic in prisoners . our data , highlight for comprehensive and integrated interventions for incarcerated idus to prevent hcv transmission among idu population and community . effectiveness of needle programs in reducing needle sharing among idus has been shown in many countries . in our country , an outreach program for blood born infections prevention was supported by the united nation and the ministry of health of iran in 2003 . multiple incarcerations was the another independent risk factor in our subjects which show that the high rates of arrests and incarcerations lead to drug - related offences or other confounding factors inside prison , such as violence . our findings suggest that preventive interventions are compelling now for idus to ensure their safe passage throughout incarceration . in our study , other important modes of transmission were frequency and length of drug injection . according to these results , harm reduction strategies need to be expanded to prevent new hcv infections , particularly among young injectors.[1920 ] in our study , history of marriage was a protective factor for hcv - infection in the subjects after controlling for all other variables in the logistic - regression model . sexual transmission could play a role in sporadic or community - acquired hcv infections . however , there is contradictory finding regarding the association between marriage and hcv infection in the world . vandelli and colleagues indicated that the risk of sexual transmission of hcv within heterosexual monogamous couples is extremely low or even null . it is shown that , those who have multiple sexual partners , including female sex workers , men having sex with men , and attendees of sexually - transmitted diseases ( stds ) clinics are the main risk groups for hepatitis c. in the acute hepatitis surveillance study in usa , 18% of newly infected individuals reported sexual contact with an hcv - infected person or multiple sexual partners as their only risk factor for hcv acquisition . for the individual with chronic hcv infection , the estimated risk of sexual transmission of virus was 0% to 0.6% per year for those in monogamous relationships , and 1% per year for those with multiple sexual partners . so , it will be useful to encourage young people to get married to prevent sexually transmitted diseases in our society . in conclusion , according to progressive reported prevalence rates of hcv in the world and the importance of the current and potential burden of hcv - related complications , it is important to primary prevention of hcv infection that will be addressed through implementation of safe injection practices . the mortality associated with hepatitis c is expected to double in the next 10 - 20 years . it is conservatively estimated that the direct costs related to hepatitis c will be $ 10.3 billion during the years 2010 - 2020 . the indirect costs of hepatitis c ( eg , the loss of productivity during that era ) are estimated to total another $ 54.3 billion due to premature death and $ 20.6 billion due to disability . in addition , the total cost of therapy for hepatitis c is estimated to be $ 10,000-$12,000 . so , primary prevention will be more cost - effective than secondary prevention of morbidity and mortality from hcv infection through provision of interferon - based therapy . it is good opportunities in prison to have large number of idus over longer period to do specific preventive activities such as needle / syringe exchange and counsel imprisoned idus .
objectives : hepatitis c virus ( hcv ) infection is a major public health problem worldwide with serious complications . according to the importance of intravenous drug use ( idu ) as the main risk factor for hcv infection and transmission and prison as the main source of risky behaviors , this study conducted to define hcv infection and related risk factors in prison inmates with history of idu in isfahan province , 
 iran.methods:this is a cross sectional study which the prison inmates with idu history in voluntary basis were enrolled . 
 a validated questionnaire was asked and blood sample was obtained from each subject for the presence of hcv antibody . 
 odds ratio and logistic regression were used for data analysis and p - value < 0.05 considered significant.results:i943 inmates with history of idu participated in the study . 
 the overall prevalence of hcv antibody was 41.6% . 
 the main independent risk factors were number of injection in the month [ or : 1.006 ( 1.002- 1.011 ) ] , length of drug addiction [ or : 1.05 ( 1.004 - 1.098 ) ] , multiple incarceration [ or : 1.15 ( 1.05 - 1.23 ) ] and use of needle / syringe share inside prison [ or : 4.19 ( 2.22 - 7.9 ) ] . in our study , 
 marriage was a protective factor for hcv infection [ or : 0.34 ( 0.18 - 0.64 ) ] as well.conclusions:according to relatively high prevalence of hcv infection and associated risk factors which observed in this study it is important to primary prevention in prisons through syringe / needle exchange and counsel with imprisoned idus .