psychiatric and psychological morbidity has been reported in patients with genital warts . even though , genital warts are generally not associated with severe symptoms , they have profound adverse impact on quality of life of patients . if patient with genital warts , complains of severe and unusual symptoms are often considered psychological . we report a case of giant genital warts where the patient complained of formication ( insect - crawling sensation ) which was subsequently found to be due to maggot infestation in the warts . a 23-year - old married woman presented with large exophytic growth arising from perineum , vulva , introitus of the vagina , and inner aspect of thighs for past 4 months [ figure 1a ] . patient developed severe itching and formication in the lesions for 1 week , though she had never seen or recovered any insect . sexual history of the patient and her husband was unremarkable . in view of giant genital wart , serum enzyme - linked immuno sorbent assay ( elisa ) for hiv and venereal disease research laboratory ( vdrl ) test for syphilis was done for both husband and the wife but were negative . ( c ) three months after complete excision using a radiofrequency device cutaneous examination revealed an approximately 10  5 cm hyperpigmented , pedunculated growth with verrucous surface over both the labial folds symmetrically , completely obliterating the introitus . on per speculum examination , a diagnosis of giant condylomata acuminata was made and it was thought that patient 's unusual complaint about the the hpv viral genotyping using linear array ( roche ) showed hpv 6 and 11 . histopathology from the warts did not show any evidence of bushke lwenstein tumor or squamous cell carcinoma . on histopathological examination hyperkeratosis , papillomatosis , koilocytosis and dilated and congested capillaries in the dermis were found . within few days of presentation , she started complaining of paroxysms of severe perineal scratching consequent to increased sensation of crawling insects . but thinking that the disease was causing immense psychological stress hence leading to the strange symptoms , serial excision of the warts with a radiofrequency device ( ellman , oceanside , ny , usa ) was planned . during the procedure , local anaesthetic ( 2% lignocaine with adrenaline ) was infiltrated in the lesion and the procedure was started . suddenly , perhaps due to irritation caused by radiofrequency current , multiple live maggots were seen coming out of verrucous masses [ figure 1b ] . the procedure was abandoned and thick white petrolatum was applied to the area . approximately 20 live maggots were then removed with the help of forceps [ figure 2 ] and few of them were sent for entomological examination . the patient was given intravenous antibiotics ( ceftriaxone and amikacin ) in view of some denuded area produced due to radiofrequency excision of few warts . a magnetic resonance imaging ( mri ) of abdomen and pelvis was done to rule out deeper soft tissue infestation and damage by the maggots which turned out to be normal . patient 's symptoms completely resolved with few more sessions of extraction of maggots over the next 2 days and subsequent examination did not reveal any maggots . some of the removed maggots later , external genital warts were completely excised with radiofrequency [ figure 1c ] . there was no recurrence of excised warts in 4-month post - operative follow - up . warts inside the vagina are being treated with imiquimod and at the time of writing this report , they have reduced substantially in size and this treatment is being continued . myiasis is a parasitic infestation of human or animal skin , necrotic tissues and natural cavities by fly larvae or pupa . human myiasis is caused by fly larvae capable of penetrating body orifices as well as healthy or necrotic tissue . patton divided myiasis - causing flies into three parasitologic categories : obligatory , facultative , and accidental . cochliomyia hominivorax , chrysomya bezziana , and wohlfahrtia magnifica are the most common flies worldwide that cause human wound myiasis . chrysomia bezziana is the most common cause of cutaneous myiasis in india but usually infests wounds and mucous membranes . predisposing factors for human wound myiasis include open wounds , poor hygiene , advanced age , psychiatric illness , diabetes , vascular occlusive disease , and physical handicap . the clinical manifestations of wound myiasis vary according to the affected body area and the extent of the infestation . patients may present with fever , pain , bleeding from the infested site or may be complicated by secondary infection and tetanus . as far as ascertained , there is only one report in literature on myiasis in genital warts from brazil in which the patient was pregnant and after removal of maggots the pregnancy ended in spontaneous abortion . myiasis in our case was unusual in view of its site and its occurrence in the absence of the usual risk factors . due to rarity of condition , and our unfamiliarity we did not consider infestation by maggots though patient complained of crawling sensation and severe itching in the genital warts . the lesson learnt is to examine and investigate the patient thoroughly before dismissing patient 's complaints as irrelevant , psychogenic or functional , however unusual and unexplainable they are for the disease . the simplest treatment for myiasis is application of an occlusive agent such as white soft paraffin , wax , glue , adhesive tape or chewing gum followed by physical removal of maggots .
a 23-year - old woman presented with large exophytic genital wart arising from perineum , vulva , introitus of the vagina , and inner aspect of thighs . 
 patient developed severe itching and formication ( insect - crawling sensation ) in the lesions for past 1 week , though careful examination did not reveal any insects . considering that the disease was causing psychological stress and physical symptoms , radiofrequency excision was planned . 
 however , during the procedure , several maggots appeared from the crypts . 
 the procedure was abandoned and maggots were removed manually . subsequently external giant warts were removed using radiofrequency device . 
 there was no recurrence of excised warts during 3 month follow - up . 
 to our knowledge , this is the second reported case of maggots in genital warts .