patients with graves orbitopathy have a higher probability of myasthenia gravis than the normal population.1 according to a large retrospective case series , myasthenia gravis was diagnosed in two of 150 patients with graves orbitopathy ( 1.3%).2 patients with graves orbitopathy commonly show eyelid retraction and/or hypotropia and/or esotropia , as well as exophthalmos , lagophthalmos , exposure keratopathy , and less frequently , compressive optic neuropathy.3 however , patients with myasthenia gravis often demonstrate ptosis and/or exotropia , but a consistent pattern of eye movement disturbances is usually not present.3 upper eyelid retraction in graves orbitopathy and myasthenia gravis ( go - mg ) is frequently camouflaged , and these patients may show a normal upper eyelid height . we herein report a patient with go - mg with left normal eyelid height , but in whom the upper eyelid retraction was disclosed after edrophonium chloride administration . a 46-year - old man with graves disease , well controlled by thiamazole 5 mg / day , was referred to our clinic to treat his graves orbitopathy . although both eyes had exophthalmos ( 20 mm od , 19 mm os ; normal range , < 17 mm)4 , he demonstrated a normal left eyelid height and right ptosis , ie , margin reflex distance-1 , 3.5 mm os and 0.5 mm od , respectively ( figure 1 ) . his primary eye position was exotropic , dominantly on his right side , and the upward gaze of the right eye was severely restricted ( figure 2 ) . coronal computed tomography of the orbits showed bilateral enlargement of the inferior rectus muscle , medial rectus muscle , superior oblique muscle , and superior rectus muscle - levator muscle complex ( figure 3a ) . axial computed tomography demonstrated bilateral medial and lateral recti muscle enlargement ( figure 3b ) . localization of these muscle involvements did not match the characteristics of the eye movement disorder ( figure 3c ) . because the aforementioned findings raised suspicion for the presence of both graves orbitopathy and myasthenia gravis , we performed an edrophonium chloride test.5 the margin reflex distance-1 had improved to 2.5 mm od and 8.0 mm os ( figure 4 ) , although the eye movement had not clearly improved . some days later , the result of a serum acetylcholine receptor antibody assay was positive ( 1.8 nmol / l ; normal , < 0.2 nmol / l ) . because the patient could completely close his left eye , we prescribed pyridostigmine bromide 180 mg / day,5 and the eyelid height stabilized the association between graves orbitopathy and myasthenia gravis has long been recognized.2,6 although it is not difficult to differentiate clinically between simple graves orbitopathy and myasthenia gravis , overlapping clinical features , such as upper eyelid height and/or eye movement disturbances occasionally cause diagnostic confusion , especially in patients with normal thyroid function . the most frequent sign of graves orbitopathy is upper eyelid retraction,7 which is caused by overaction of the mller s muscle because of excess catecholamines and cicatricial contraction of the levator muscles after the inflammatory process.7 for the overaction , topical guanethidine therapy is sometimes effective.8 for the contraction , steroid administration and botulinum toxin injection are indicated during the active phase , and surgical correction is necessary in the static phase.7 graves orbitopathy also shows eye movement disturbances , which have a restrictive myopathy pattern.3 the inferior and medial rectus muscles are frequently involved , and imaging discloses their hypertrophy when in the active phase . on the other hand , ptosis and diplopia are present in about 90% of patients with myasthenia gravis , and these ocular symptoms are an initial complaint in 20% of patients with myasthenia gravis.911 muscle hypertrophy does not exist on imaging in myasthenia gravis.12 no particular predilection of extraocular muscle involvement is shown in myasthenia gravis . however , solitary paresis usually occurs , in the form of an adduction deficit resulting in exotropia , which was the case in the present patient . exotropia is more common in ocular myasthenia gravis.3 in spite of the obvious differences between graves orbitopathy and myasthenia gravis , each condition shares several features , potentially making it difficult to reach a correct diagnosis . upper eyelid ptosis , typically suggestive of myasthenia gravis , may be seen with graves orbitopathy as a result of levator myopathy,13 apical compression,14,15 and pseudoptosis secondary to upper eyelid retraction in the fellow eye.16 however , if ptosis develops in a patient with graves orbitopathy , simultaneous myasthenia gravis should be considered,17 although ocular myasthenia gravis with orbital pain may imply orbital inflammation.18 in our patient , the right ptosis and exotropia suggested concomitant myasthenia gravis , which motivated us to perform an edrophonium chloride test . the left upper eyelid , appearing to have a normal height , was retracted to margin reflex distance-1 8.0 mm , and the right side , regarded as ptosis , moved to margin reflex distance-1 2.5 mm ( figure 4 ) . this examination demonstrated that the left upper eyelid originally had an upper eyelid retraction that was camouflaged by the ocular myasthenia gravis . treatment of our patient was complicated because of laterality and strabismus induced by myasthenia gravis . when the eyelid height stabilizes after medication with improvement of strabismus , a sling surgery may be performed on the right upper eyelid . however , if strabismus persists , this strategy must be abandoned . when left upper eyelid retraction is conspicuous with lagophthalmos , left upper eyelid lengthening surgery may be performed.19 in conclusion , upper eyelid retraction in patients with go - mg may be camouflaged by a myasthenia effect . the upper eyelid height must be carefully monitored in patients with graves orbitopathy to detect the presence of concomitant myasthenia gravis .
patients with graves orbitopathy have a higher probability of myasthenia gravis than does the normal population . 
 overlapping clinical features cause diagnostic confusion in such a situation . 
 we herein report a patient with graves orbitopathy and myasthenia gravis ( go - mg ) with normal left eyelid height , but in whom upper eyelid retraction was shown after edrophonium chloride administration . 
 upper eyelid retraction in go - mg is occasionally masked by a myasthenia effect . 
 the upper eyelid height must be carefully monitored in patients with graves orbitopathy to detect the presence of concomitant myasthenia gravis .