malignant tumors which originated from mesenchymal tissue , has occurred very rarely in the breast . the metaplastic carcinomas which have characterized by a combination of mesenchymal and epithelial components would be uncommon malignancies of the breast . the chondrosarcoma has been a typical example of these rarest tumors of the mesenchymal tissue . a 65 years old man has presented in our department with a complaint of a right sided breast mass which has rapidly grown for 5 months . breast palpation has revealed a painless , less mobile , and firm to hard mass of 1010 cm with regular margins in area of right breast . contrast enhanced mri ( figures 1a and b ) of breasts has revealed huge mixed signal intensity multi lobulated cystic - solid extra - pulmonary mass lesion involving the right anterior chest wall extending from infra clavicular region to the level of xiphisternum measuring 10.4 cm ( si )  10.3 cm ( ap )  9.9 cm ( trans ) appearing predominantly hyper intense on t2w and hypo intense on t1w . heterogeneous predominantly peripheral solid tumoral enhancement has observed with multiple large loculated central areas of necrosis and intensely enhancing septae . histopathology has revealed the overall appearances of low - grade chondrosarcoma with a tumor composed of lobules of cartilage of varying size separated by fibrous tissue . immunohistochemical studies have performed by standard revealed that chondrosarcomatous elements were positive for s-100 and vimentin , but negative for cytokeratin and also for estrogen and progesterone receptors . this paper has discussed one of the rarest mesenchymal malignancies of the breast , primary chondrosarcoma . as a primary breast tumor , chondrosarcoma might occur in three different forms : as a pure neoplasm ( pure chondrosarcoma ) , as the stromal component of a histologically malignant phyllodes tumor , or as chondrosarcomatous differentiation in a metaplastic carcinoma . in this report prognosis of chondrosarcomatous breast tumors has not fully known , because many of the reported cases were difficult to analyze ( owing to lack of detailed clinical or morphologic information ) . these tumors were usually large - sized that have occurred in more than 40 year old woman . axillary lymph nodes have found in 14 - 29% of the cases , most of which were reactive hyperplasia . the present case substantiates the clinical findings of previously reported cases . to diagnose a primary chondrosarcoma of the breast , other types of pure sarcoma , such as spindle cell sarcoma , neuroectodermal tumor , angiosarcoma etc , have also been reported [ 6 , 7 ] . the history of the patient had an important feature as the mass had grown rapidly without systemic and deleterious effect on the patient s health status . these tumors have tended to grow rapidly and present themselves as a mass for a short duration [ 2 , 3 , 7 ] . a large multilobular mass with regular margins and without a sign of regional invasion has detected by palpation . previous reports have also pointed out that these large tumors have not generally invaded skin and regional lymph nodes despite their locally advanced nature [ 2 - 4 , 7 ] . a relatively circumscribed , well demarcated mass , as in our patient , was an imaging characteristic of a pure mesenchymal or a metaplastic carcinoma with sarcomatoid differentiation . it has been redported that imaging studies seldom led to the diagnosis of sarcoma in a suspected benign lesion . the mass was complex echoic on ultrasound and has shown round hyperdense opacity on mammography [ 4 , 7 , 8 ] . the very limited number of such cases has not permitted us to establish an appropriate therapeutic approach . chondrosarcoma in common locations has generally known as refractory to all types of conventional chemotherapy and radiotherapy . pure chondrosarcoma and metaplastic cancer of the breast has rarely invaded axillary lymph nodes and would be generally hormone receptor - negative [ 1 , 2 , 4 , 11 ] . this extremely rare tumor has tended to grow rapidly , and it was usually large at first physical examination . a large , hyper dense and complex echoic mass with regular margins has given the impression of a benign tumor on mammography and ultrasound . despite its large size , it has not invaded local and regional structures . regarding systemic management , there was no standard treatment protocol , and a large variety of chemotherapy protocols have been employed in treating this disease . systemic therapy principles have been derived from small retrospective case reviews of primary breast chondrosarcomas and extrapolated from studies of non - breast chondrosarcomas , since the clinical behavior and histology were similar . this fact has been supported the theory that adjuvant therapy with estrogen antagonists and other hormone manipulations had no role in treatment of mammary sarcomas . the adjuvant treatment could decrease the rates of local and systematic recurrences , but the results were not significant because of the rarity of this pathological entity and the small numbers of cases have reported , which made the evaluation of the role of the chemotherapy and the radiotherapy in the primary breast chondrosarcoma more difficult . it has seemed to be very important to identify the mammary primary sarcomas as entity separated from the carcinomas of the breast . the primitive chondrosarcoma has remained a rare pathology , among which the therapeutic modalities and the forecast were credibly identical to those of the sarcomas of the same type arising in the other localizations . it has seemed to be very important to identify the mammary primary sarcomas as entity separated from the carcinomas of the breast . the primitive chondrosarcoma has remained a rare pathology , among which the therapeutic modalities and the forecast were credibly identical to those of the sarcomas of the same type arising in the other localizations .
breast sarcomas have relatively been rare and accounted for 1% of all primary malignant tumors of the breast . 
 pure and primary chondrosarcoma of the male breast would be an extremely rare tumor . 
 it might arise either from the breast stroma itself , or from underlying bone or cartilage . 
 a 65-year - old man has presented with a rapidly growing breast mass since 5 months . 
 physical examination has established a large firm to hard mass with regular margins in the region of right breast . 
 there was no axillary lymphadenopathy . 
 contrast enhanced mri of breasts has shown a mixed - signal intensity multi lobulated cystic - solid mass ( 10.4 cm  10.3 cm 9.9 cm ) appearing predominantly hyper intense on t2w and hypo intense on t1w . 
 the tumor has diagnosed as a low - grade chondrosarcoma of the breast by histopathological and immunohistochemistry analysis . 
 right sided radical mastectomy with grafting has done . 
 it has seemed to be very important to identify the mammary primary sarcomas as entity separated from the carcinomas of the breast .