at this institution , a retrospective review was performed and 36 consecutive patients were identified with decompensated cirrhosis with refractory or large - volume ascites where indwelling peritoneal catheter placement was utilized . each patient had biopsy - proven cirrhosis , and an etiology was determined for each patient . records reviewed included complete blood count , comprehensive metabolic panel , coagulation panel , viral serologies , and biopsy reports . all patients were up to date with alpha - fetoprotein and abdominal ultrasound testing for hepatocellular carcinoma with three patients undergoing active therapy . a pigtail catheter was utilized and placed into the peritoneal cavity via the seldinger technique under sterile procedure ( 10 , 12 ) . prior to placement , the patient was evaluated with both shifting dullness and abdominal ultrasound to document large - volume ascites . a site was determined with shifting dullness or abdominal ultrasound , whichever was more appropriate . after site determination , a surgical scrub was utilized to prep the surface and a sterile drape was placed overlying the area . under sterile technique , the skin was anesthetized with 510 ml of 1% xylocaine solution . free fluid was aspirated with the small 22-gauge needle to assure adequate placement and positioning . a needle was then introduced into the peritoneal space through the anesthetized tract . the pigtail catheter a locking device was then placed on the catheter . the drain was then sutured in using a 2 - 0 prolene . ascites was removed at a rate of 3 l every 8 h. if 3 l was achieved , the nursing staff would utilize the locking device to halt additional fluid output until an 8-h shift had passed before again allowing gravity drainage to take place . albumin ( 25% , 50 g ) was infused if 3 l was removed in the 8-h shift . daily ascitic fluid cell counts were performed in addition to daily laboratory profiles with complete blood count ( cbc ) and comprehensive metabolic panel ( cmp ) . all patients signed an informed written consent for paracentesis with indwelling peritoneal drainage for up to 72 h. in addition , this retrospective study was approved by the institutional review board at university of illinois college of medicine at peoria . analysis was conducted with sas 9.4 ( by sas institute inc , cary , nc , usa ) . descriptive results were reported as meanstandard deviation for continuous variable , and percentage for categorical variable . generalized estimating equations were used to estimate and compare clinical characteristics at different time points . a two - tailed p value was calculated for all tests , and p0.05 is considered as being statistically significant . the values of serum creatinine improvement , albumin infused , plasma white blood cell count , ascitic fluid white blood cell count , and blood urea nitrogen ( bun ) are given in table 2 . the mean ascitic fluid removed on day 1 , 2 , and 3 was 6.60 , 5.72 , and 4.21 l respectively . the amount of albumin given directly correlated with the amount of fluid removed with 80.76 , 68.26 , and 60.0 g being infused on day 1 , 2 , and 3 , respectively , correlating to 12 the mean weight on day 1 was 86.5 kg ( range : 75.997.0 kg ) , and on day 3 , it was 77.8 kg ( range : 66.888.8 kg ) . serum creatinine declined statistically from 1.37 on day 1 to 1.21 on day 3 ( p<0.05 ) . predicted values ( mean , 95%ci ) of clinical characteristics based on generalized estimation equations 
 p<0.05 compared to the baseline ( day 1 ) . follow - up within 26 weeks . at a follow - up at a mean time of 17 days , serum bun values were not affected significantly throughout with mean values of 31.1 , 31 , 29 , and 25.5 mg / dl on day 1 , 2 , 3 , and follow - up , respectively . no patient required a repeat paracentesis or indwelling peritoneal drain for at least 2 weeks after the initial drain placement . no patient was noted to develop any clinical signs or laboratory evidence of infection or secondary bacterial peritonitis . the ascitic fluid white blood cell count trended upwards from 126 on day 1 to 234 on day 3 . none of the patients met the criteria for secondary bacterial peritonitis of neutrophil count > 250 cells/l . the most common complaints encountered were pain at insertion site in seven patients and minor bleeding in two patients as represented in table 3 . paracentesis is known to reduce short - term mortality and improve outcomes in patients with cirrhosis . a nationwide analysis showed in - hospital mortality reported to be lower in decompensated cirrhosis patients who underwent paracentesis within 24 h of admission ( 5.7% vs 8.1% ; p=0.49 ) ( 13 ) . traditionally , large - volume paracentesis with colloid infusion has been shown to be more effective than diuretics alone in managing ascites in hospitalized patients ( 5 ) . this often results in large - volume shifts with development of intravascular volume depletion and renal insufficiency . , we attempted to demonstrate the efficacy and safety of indwelling peritoneal catheter placement for refractory and large - volume ascites , especially its effect on renal function . patients with refractory ascites often have contraindications to the use of diuretics due to their concomitant renal dysfunction , fostering electrolyte imbalance and precipitating hepatic encephalopathy ( 14 ) . while previous studies have documented its safety , its role in maintaining renal function has not been reported . it has been shown that increased intra - abdominal pressure can cause acute renal failure in humans and animals ( 15 , 16 ) . removal of this pressure resulted in immediate improvement in renal function and resolution of anuria ( 1619 ) . in our study , a mean of 16.53 l of fluid was removed over a period of 72 h. this corresponded with a mean drop of 8.7 kg body weight between day 1 and day 3 . the removal of this volume of fluid from the patient alone could be responsible for causing a significant improvement in renal perfusion and subsequent renal function seen in our patient population , secondary to reduced intraperitoneal pressures . large - volume paracentesis supported with albumin infusion has been shown to decrease the risk of post - paracentesis related circulatory dysfunction ( ppcd ) . it has been reported that the use of albumin was associated with a significantly reduced risk of ppcd ( reducing odds by 66% ) and reduction in morbidity and mortality by 36% . while this reduction in ppcd is mainly believed to be due to albumin , the slow gravity - dependent removal of large volume of fluid could play a further role in preventing this complication ( 20 ) . moreover , slow gravidity - dependent removal of ascites along with albumin infusion not only helps in effective removal of ascitic fluid but also facilitates fluid movement from the interstitium into the vascular space due to the increased oncotic effect of albumin in the plasma . this also plays a role in preventing the rapid re - accumulation of fluid as well as improved renal perfusion ( 10 ) . in this study g on days 1 , 2 , and 3 , respectively , with albumin infusion directly correlating with the amount of fluid evacuated . it has already been demonstrated that albumin infusion helps in the resolution of hepatorenal syndrome ( 21 ) . we believe that this slow gravity - dependent removal of ascites along with albumin infusion could have a further beneficial role in preventing renal dysfunction and subsequent development of hepatorenal syndrome , but more prospective studies are needed to validate such findings . overall there is a paucity of literature regarding the efficacy and side effects of an indwelling catheter in the management of non - malignant refractory ascites 1012 . in addition , concerns have been raised regarding the risk of bacterial peritonitis with the use of indwelling peritoneal catheters ( 11 , 12 , 15 ) . recently , a retrospective observational study reported the risk of secondary bacterial peritonitis as high as 10% in patients with indwelling peritoneal catheters . this was based solely of neutrophilic criterion of fluid analysis and did not correlate with cultures or known clinical decompensation after drain removal ( 11 , 22 ) . in our study , none of our 36 patients developed bacterial peritonitis in the 72-h time frame of indwelling peritoneal catheter . our ascitic fluid white blood cell count trended from a mean value of 126/mm on day 1 to 234/mm on day 3 . this trend likely represents several pathophysiologic processes occurring in patients with an indwelling peritoneal catheter . the first is a concentration of the ascitic fluid volume within the peritoneal cavity , thereby increasing all cellular material per unit of measurement . the second is mild abdominal wall irritation from the drain catheter with a resulting mild inflammatory response . in addition , over a 4-week follow - up period , no patients presented to the hospital with clinical findings or laboratory evaluation consistent with bacterial peritonitis . the most common side effects encountered in our study were pain at insertion site in seven patients ( 19.4% ) and minor bleeding from the drain site in two patients ( 5.6% ) . both cases of minor bleeding responded to local pressure for 10 min to the insertion site with no recurrence . the mortality also did not seem to be affected by drain placement with average survival being around 22 months after drain placement varying in different patients according to the severity of their respective meld scores ( 11 ) . our results are consistent with a previous study done by van thiel and colleagues . in their study the duration of indwelling drain placement was up to a maximum of 72 h similar to our study . the most common complaint accompanied in their study was abdominal wall discomfort in 63% of the patients and abdominal wall hematoma in 5% of the patients ( 10 , 22 ) . another study by nadir and colleagues showed the risk of spontaneous bacterial peritonitis ( sbp ) to be more only in those patients in whom the drain was left in for more than 3 days ( 12 ) . in addition , previous studies have shown increased risk of concurrent proton pump inhibitor ( ppi ) therapy and development of sbp ( 23 , 24 ) . this risk is greater with a ppi therapy ( n=3,815 ; or 3.15 , 95% ci 2.094.74 ) as compared with those on h2 therapy ( n=562 ; or 1.71 , 95% ci 0.973.01 ) ( 25 ) . in our study 30 ( ~75% ) patients were on some form of ppis while the indwelling catheter was placed in and none had clinical sbp , thus suggesting that ppis did not enhance the risk of developing sbp . in conclusion , continuous paracentesis with an indwelling peritoneal catheter represents an important modality in the evacuation of ascites in selected patients . this technique when used for less than 72 h and with albumin infusion can be a safe and effective means to manage patients in the hospital with large - volume tense ascites . sw , za , and kr collected the data ; rj analyzed the data ; and dm and sd reviewed the literature and made critical revisions related to the content of the article . the authors have not received any funding or benefits from industry or elsewhere to conduct this study .
backgroundthe management of ascites can be problematic . 
 this is especially true in patients with diuretic refractory ascites who develop a tense abdomen . 
 this often results in hypotension and decreased venous return with resulting renal failure . in this paper 
 , we further examine the risks and benefits of utilizing an indwelling peritoneal catheter to remove large - volume ascites over a 72-h period while maintaining intravascular volume and preventing renal failure.methodswe retrospectively reviewed charts and identified 36 consecutive patients undergoing continuous large - volume paracentesis with an indwelling peritoneal catheter . at the time of drain placement , no patients had signs or laboratory parameters suggestive of spontaneous bacterial peritonitis . 
 the patients underwent ascitic fluid removal through an indwelling peritoneal catheter and were supported with scheduled albumin throughout the duration . 
 the catheter was used to remove up to 3 l every 8 h for a maximum of 72 h. regular laboratory and ascitic fluid testing was performed . 
 all patients had a clinical follow - up within 3 months after the drain placement.resultsan average of 16.5 l was removed over the 72-h time frame of indwelling peritoneal catheter maintenance . 
 the albumin infusion utilized correlated to 12 mg / l removed . 
 the average creatinine trend improved in a statistically significant manner from 1.37 on the day of admission to 1.21 on the day of drain removal . 
 no patients developed renal failure during the hospital course . 
 there were no documented episodes of neutrocytic ascites or bacterial peritonitis throughout the study review.conclusionlarge-volume peritoneal drainage with an indwelling peritoneal catheter is safe and effective for patients with tense ascites . 
 concomitant albumin infusion allows for maintenance of renal function , and no increase in infectious complications was noted .