plica neuropathica is an acquired , rare condition characterized by sudden and irreversible matting of scalp hair in otherwise healthy individuals . it was formerly supposed to be a disease peculiar to poles ( hence named as plica polonica ) and was usually the result of neglect or parasitic infestations . subsequently , other factors such as shampoos , conditioners , herbal soaps , and psychiatric morbidity were also reported to result in matting of scalp hair . a dermatology consult was sought for a 65-year - old female who developed severe matting of scalp hair for 1 week . she was admitted under medical services for the management of azathioprine ( 50 mg once daily for a month ) induced pancytopenia , which was prescribed for pulmonary sarcoidosis . she gave a history of loss of hair from frontal area of scalp , that came out in bunches , followed by spontaneous tangling of hair over the top of her head to form a stiff protuberant mass [ figure 1 ] . she had no features of scabies or lice and shampooed her hair once a week with a non medicated shampoo . there was no history of use of any chemical treatment for her hair such as streaking or straightening of hair . examination of scalp revealed diffuse non scarring loss of hair over the frontal area and a mass of solid irregular matted hair located over the vertex , approximately 10 cm in height [ figure 1 ] . investigations revealed total leucocyte count of 0.9  10/l ( reference range 4.011.0  10/l ) , hemoglobin of 7.4 g% ( reference range 1215.5 g% ) , and platelet count of 0.49  10/l ( reference range 1.54.5  10/l ) . examination revealed noncicatricial hair loss over the frontal region and elongated stiff protuberant mass of matted hair on the vertex which could not be detangled . the matting of hair in case 1 . also diffuse hair loss form the scalp can be appreciated a 30-year - old female was referred for the sudden loss of hair and severe tangling of hair that could not be combed for 3 days . her medical history was significant for the development of hydatidiform mole followed by methotrexate induced pancytopenia , severe stomatitis , and erythema multiforme over hands , feet , and upper trunk [ figure 2a ] . she was on methotrexate 25 mg once a day for 5 days , two cycles given over a period of 1 month . during her hospital stay , she found difficulty in combing her hair that became extensively tangled . over next few days , she tried to comb her hair without success and found that her hair had been irreversibly matted and also the loss of hair over frontal area of scalp [ figure 2b ] . there was no history of skin or hair disease in past , and she regularly shampooed her hair once or twice a week . pertinent investigations revealed total leucocyte count of 1  10/l ( reference range 4.011.0  10/l ) , hemoglobin of 8 g% ( reference range 1215.5 g% ) , platelet count of 0.55  10/l ( reference range 1.54.5  10/l ) and peripheral blood film predominantly normocytic normochromic . on examination , she had extensive noncicatricial alopecia involving the middle two - third of the scalp . she was managed conservatively for pancytopenia and scalp hair were shaved off as a part of treatment for plica . a dermatology consult was sought for a 65-year - old female who developed severe matting of scalp hair for 1 week . she was admitted under medical services for the management of azathioprine ( 50 mg once daily for a month ) induced pancytopenia , which was prescribed for pulmonary sarcoidosis . she gave a history of loss of hair from frontal area of scalp , that came out in bunches , followed by spontaneous tangling of hair over the top of her head to form a stiff protuberant mass [ figure 1 ] . she had no features of scabies or lice and shampooed her hair once a week with a non medicated shampoo . there was no history of use of any chemical treatment for her hair such as streaking or straightening of hair . examination of scalp revealed diffuse non scarring loss of hair over the frontal area and a mass of solid irregular matted hair located over the vertex , approximately 10 cm in height [ figure 1 ] . investigations revealed total leucocyte count of 0.9  10/l ( reference range 4.011.0  10/l ) , hemoglobin of 7.4 g% ( reference range 1215.5 g% ) , and platelet count of 0.49  10/l ( reference range 1.54.5  10/l ) . examination revealed noncicatricial hair loss over the frontal region and elongated stiff protuberant mass of matted hair on the vertex which could not be detangled . the matting of hair in case 1 . also diffuse hair loss form the scalp can be appreciated a 30-year - old female was referred for the sudden loss of hair and severe tangling of hair that could not be combed for 3 days . her medical history was significant for the development of hydatidiform mole followed by methotrexate induced pancytopenia , severe stomatitis , and erythema multiforme over hands , feet , and upper trunk [ figure 2a ] . she was on methotrexate 25 mg once a day for 5 days , two cycles given over a period of 1 month . during her hospital stay , she found difficulty in combing her hair that became extensively tangled . over next few days , she tried to comb her hair without success and found that her hair had been irreversibly matted and also the loss of hair over frontal area of scalp [ figure 2b ] . there was no history of skin or hair disease in past , and she regularly shampooed her hair once or twice a week . pertinent investigations revealed total leucocyte count of 1  10/l ( reference range 4.011.0  10/l ) , hemoglobin of 8 g% ( reference range 1215.5 g% ) , platelet count of 0.55  10/l ( reference range 1.54.5  10/l ) and peripheral blood film predominantly normocytic normochromic . on examination , she had extensive noncicatricial alopecia involving the middle two - third of the scalp . she was managed conservatively for pancytopenia and scalp hair were shaved off as a part of treatment for plica . in 1884 , when le page first described a case of acute matting of scalp hair , he referred to it as plica neuropathica as he believed it stemmed from hysterical tendencies . it was prevalent in poland in the 19 century , hence was named plica polonica or polish plait . it presents as a compact mass of scalp hair with irregular twists and irreversibly entangled plaits which are firm to hard impenetrable mass of keratin cemented together with dirt and exudates . the process of matting is essentially similar to the phenomenon of  felting  which occurs in wool and textile industries in which there is compacting of contiguous fibers exposed to surface damage and friction . it occurs when fibers are stirred together in a liquid medium and are subsequently exposed to increased functional forces . if the hair is rubbed along its shaft , it gets electrically charged with positive polarity if the friction is toward the root and negative if friction is toward the free end . probably matting of hair does not occur either from electrostatic attractions or from liquid crystal formation but from the combination of the two . the exact mechanism for matting is not well - understood but both physical and chemical factors that damage hair shafts may play a role [ figure 3 ] . plausible mechanisms of pathogenesis of plica neuropathica various etiologies have been propounded from time to time . a thorough review of the available literature has led to a plethora of causes [ table 1 ] . the various etiological factors of plica neuropathica temporary hair loss ( alopecia ) is a common side effect of chemotherapy . hair follicles ( hf ) are  hair shaft - producing miniorgans  showing during postnatal life a unique pattern of cyclic activity with periods of active growth ( anagen ) , relative resting ( telogen ) , and apoptosis driven involution ( catagen ) . hf 's are strongly affected by many chemotherapeutic agents because of the rapid proliferative rate of hair matrix keratinocytes during anagen . immunosuppressive drugs commonly lead to anagen effluvium due to abrupt cessation of mitotic activity in the rapidly dividing hair matrix cells so that either no hair is produced , or a narrowed and defective hair shaft is produced and the hair loss is evident within days to weeks of drug administration . however , azathioprine is not normally known to be a cause of anagen effluvium and it is possible that the sudden pancytopenia results in hair shaft damage leading to hair loss and hair shaft cuticular damage resulting in matting of hair . plica neuropathica generally affects healthy persons but has been described in a 54 years and a 14-year - old chronically ill female with azathioprine - induced pancytopenia , without any history of neglect , parasitic infestation , and shampooing . on the other hand , methotrexate has not been reported to cause matting of hair though it can lead to hair fall . antimitotic chemotherapeutic agents such as methotrexate induce arrest of the anagen phase and present a toxic insult to the rapidly dividing hair matrix . hair loss usually begins 12 weeks after chemotherapy is started and is most noticeable by 12 months . these antimetabolite drugs induce dystrophic changes in the new follicles as well as in the already growing hf . they also lead to premature regression as a result of massive apoptosis in the entire proximal hair bulb leading to subsequent hair shedding . when functional forces are applied to the already damage cuticle of the long and old hair , proximity of shafts increases , and tangling occurs leading to plica . furthermore the unfruitful efforts by the patient to comb the unruly hair lead to electrostatic attraction and increase the chances of matting of the long and old hair . the chemotherapy - induced hair loss and the effects on the growing hf , and the resultant cuticular damage is much more complex than previously appreciated and may require distinct molecular studies to further collaborate these theories . both of our patients agreed to the manual removal of hair as a part of treatment . however , it can still be prevented from developing by adequate hair care and washing habits . prevention measures that can be adopted are : 
 regular cleaning of hair with mild cleansers or shampoosgentle oiling and combing to avoid entanglingregular hair trimmingavoid hair piling over vertex while washing and backcombingavoid rotatory rubbing of hairlong hair should be given a backwash or be washed in the sink . regular cleaning of hair with mild cleansers or shampoos gentle oiling and combing to avoid entangling regular hair trimming avoid hair piling over vertex while washing and backcombing avoid rotatory rubbing of hair long hair should be given a backwash or be washed in the sink . matting of hair in two patients on azathioprine and in a patient on chemotherapy ( doxorubicin , cyclophosphamide and cisplatin after surgery for papillary cystadenoma ovary ) following washing of hair with a soap containing acacia concinna , have been reported previously . the current report is probably only the third case of plica neuropathica associated with azathioprine - induced pancytopenia and first with methotrexate in literature and unusual in that it occurred not because of neglect and poor hair care or overzealous shampooing of hair but due to cuticular damage of hair shaft secondary to the immunosuppressive drug induced pancytopenia . we consider that matting of hair is not truly a hair disorder , rather a reaction resulting from the interplay of great motley of factors . moreover , the role of myriad factors such as chronic illness , hospital stay , pancytopenia , and drug induced cuticular damage is still debatable .
plica neuropathica also known as  birds nest  is irreversible matting of hair seen in otherwise healthy individuals and is usually associated with use of ionic / herbal soaps , shampoos , parasitic infestations , psychiatric alterations , or neglect . 
 anagen effluvium is a known side effect of many immunosuppressive drugs . 
 rarely matting of hair has been reported following azathioprine . 
 we report plica neuropathica in two chronically ill patients on immunosuppressive drugs , that is , azathioprine and methotrexate along with a review of literature of its etiological factors and pathogenesis .