the prediction of a patient 's growth potential is of clinical significance because it determines the optimal timing of starting or stopping bracing and the timing of growth - guidance surgery with an expandable prosthesis.1 
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 4 many clinical and radiologic methods are available to predict a patient 's growth potential including the age at menarche , difference in body height growth and arm span , risser sign , and tanner and whitehouse ( tw3 ) digital skeletal age.5 
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 8 however , most of these measures have disadvantages in the current clinical practice.9 clinical measurements of standing height and arm span require serial measurements to determine growth trends , and its retrospective nature thus likely misses the period of peak growth spurt . the menarche age is not consistent in determining the termination of peak growth as some patients develop delayed menarche and its presence marks a stage too late for any meaningful bracing.10 similar to menarche , the risser sign has been shown by several studies to be a poor indicator of skeletal maturity , cessation of growth , and more importantly the risk of curve progression.11 
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 15 up to 75.2% of patients may have persistent growth despite capping of the iliac apophysis.13 in addition , the progression of iliac apophysis has been shown to proceed in a reverse direction ( posteromedially to anterolaterally ) or in fragments.15 the digital skeletal age assessment using the tw36 
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 8 or the greulich and pyle16 methods are more accurate in determining different growth phases , but these techniques are complex and far too difficult to apply in the clinical setting . sanders et al showed that according to the tw3 , the finger epiphysis maturation is closely related to the peak height velocity.17 the peak height velocity is noted to occur during early adolescence , and menarche and the risser sign appear after the peak growth spurt.18 
  in response to the limitations possessed by the previous methods in assessing skeletal maturity , the distal radius and ulna ( dru ) classification was created and reported by luk et al.19 this classification , which included 11 radius grades ( r1 to r11 ) and 9 ulna grades ( u1 to u9 ) , was found to accurately determine the peak height velocity ( r7 and u5 ) and cessation of growth ( r10 and u9 ) . however , the reliability of the classification has not been assessed . as such , the following study aimed to test the classification 's reliability . a prospective radiographic study assessing patients with adolescent idiopathic scoliosis ( ais ) undergoing bracing during the month of july 2014 was performed to assess the reliability of the dru classification.19 ethics approval was obtained from our institutional review board . the study was performed at the duchess of kent children 's hospital , pokfulam , hong kong , a tertiary referral center for spinal disorders . for the dru classification to be practical clinically , the reliability testing should be based on a wide range of patient ages , as commonly seen in our clinics . in addition , the aim of this classification was to correctly identify patients in the peak growth spurt so that timely interventions can be applied . thus , choosing braced patients would likely encompass a larger range of grades and avoid reliability assessment of only a certain age group or dru grade . the follow - up left - hand radiographs during the study month were obtained in all subjects , and data was extracted regarding the age at which the radiograph was taken and the sex of the patient . these anteroposterior radiographs of the hand and wrist were taken with 42 peak kilovoltage and 1.6 ma - seconds of x - ray energy . k.d .- k.l . ) , one junior and one senior consultant spine surgeon , for grading . there was no discussion between the two examiners about how to classify each grade prior to the initiation or during the study . radiographs were accessed by a dicom - based radworks 5.1 ( applicare medical imaging bv , zeist , the netherlands ) computer software program . all data was coded and entered on a spreadsheet and was blinded to the examiners until the end of reliability measurements . spss version 20 ( chicago , illinois , united states ) was utilized to perform the statistical analysis . the reliability assessment was based on intraclass correlation ( icc ) , which was an appropriate statistical tool for this analysis.20 icc could be interpreted based on the following  values : 0 to 0.29 indicated poor agreement ; 0.30 to 0.49 indicated fair agreement ; 0.50 to 0.69 indicated moderate agreement ; 0.70 to 0.80 indicated strong agreement ; and > 0.80 indicated almost perfect agreement.21 
 22 the 95% confidence interval ( ci ) bounds were assessed for precision . a p value of < 0.05 was considered significant . all data was coded and entered on a spreadsheet and was blinded to the examiners until the end of reliability measurements . spss version 20 ( chicago , illinois , united states ) was utilized to perform the statistical analysis . the reliability assessment was based on intraclass correlation ( icc ) , which was an appropriate statistical tool for this analysis.20 icc could be interpreted based on the following  values : 0 to 0.29 indicated poor agreement ; 0.30 to 0.49 indicated fair agreement ; 0.50 to 0.69 indicated moderate agreement ; 0.70 to 0.80 indicated strong agreement ; and > 0.80 indicated almost perfect agreement.21 
 22 the 95% confidence interval ( ci ) bounds were assessed for precision . a p value of < 0.05 was considered significant . one hundred sixty - one subjects ( 124 females and 37 males ) satisfied our inclusion criteria and were recruited for this study . the mean age was 13.3 ( standard deviation : 1.5 ; range : 8 to 18 ) . the interobserver reliability was icc  =  0.97 ( 95% ci : 0.96 to 0.98 ) and icc  =  0.97 ( 95% ci : 0.96 to 0.98 ) for the radius and ulna , respectively . was icc  =  0.93 ( 95% ci : 0.91 to 0.95 ) for the radius and icc  =  0.95 ( 95% ci : 0.930.96 ) for the ulna ; for k.d .- k.l . , icc  =  0.94 ( 95% ci : 0.91 to 0.95 ) for the radius and icc  =  0.95 ( 95% ci : 0.93 to 0.96 ) for the ulna . , there were 18 one - grade disagreements ( 11.1% ) and 1 two - grade disagreement ( 0.6% ) . for the ulna , there were 39 one - grade disagreements ( 24.1% ) and 1 two - grade disagreement ( 0.6% ) . was as follows : for the radius , there were 28 one - grade disagreements ( 17.3% ) and 5 two - grade disagreements ( 3.1% ) . for the ulna , there were 42 one - grade disagreements ( 25.9% ) and 2 two - grade disagreements ( 1.2% ) . the intraobserver disagreement for k.d .- k.l . was as follows : for the radius , there were 26 one - grade disagreements ( 16.0% ) and 4 two - grade disagreements ( 2.5% ) . for the ulna , there were 40 one - grade disagreements ( 24.7% ) and 5 two - grade disagreements ( 3.1% ) . for the radius , there were 18 one - grade disagreements ( 11.1% ) and 1 two - grade disagreement ( 0.6% ) . for the ulna , there were 39 one - grade disagreements ( 24.1% ) and 1 two - grade disagreement ( 0.6% ) . the intraobserver disagreement for j.p.y.c . was as follows : for the radius , there were 28 one - grade disagreements ( 17.3% ) and 5 two - grade disagreements ( 3.1% ) . for the ulna , there were 42 one - grade disagreements ( 25.9% ) and 2 two - grade disagreements ( 1.2% ) . the intraobserver disagreement for k.d .- k.l . was as follows : for the radius , there were 26 one - grade disagreements ( 16.0% ) and 4 two - grade disagreements ( 2.5% ) . for the ulna , there were 40 one - grade disagreements ( 24.7% ) and 5 two - grade disagreements ( 3.1% ) . from this study , we found that the dru classification had excellent reliability among a wide range of radius and ulna grades.19 although we did not have patients young enough to present with radius stages r1 to r4 , interventions for ais such as bracing are only applicable during the peak growth spurt . the r6 to r9 and u5 to u8 were important grades because they represented the period of peak growth spurt , and these grades were well represented in our testing . after all measurements were made through this vigorous process of testing , the two examiners thoroughly discussed each grade description and were able to form a consensus about which aspects of the classification were more representative and easier to apply during reading . the difficulties encountered by both readers during testing mainly arose from the grading of r7 to r9 and u5 to u8 . both reviewers agreed that the grading of r7 to r9 and u5 to u8 were the most difficult because they were based on descriptions of multiple parameters . each clinician might focus on something different , such as the appearance of the physis narrowing , the definition of capping , and when the epiphysis acquired the same width as the metaphysis , among others . disagreements in the ulna grades appear larger than the radius grades , likely due to a larger range of ulna grades measured as compared with the radius . for the radius , the main identifying factor between r7 and r8 was the appearance of capping over the medial side in r7 ( fig . 1 ) and over the lateral side in r8 ( fig . 2 ) . both readers agreed that capping was defined as a hornlike structure at the ends of the epiphysis like a sharp bony outgrowth . a simple step to confirm this observation on the radius was to trace the proximal border of the epiphysis to find any dipping of the line toward the metaphysis at the medial or lateral ends . for r9 ( fig . 3 ) , strong capping was not always a consistent finding , thus narrowing of the physis was the main determinant description for this grade . examiners should focus on the medial side capping and the absence of lateral side capping ( red arrow ) . note the hooklike structure / sharp outgrowth at the medial physis facing the metaphysis that deviates from the physeal line . this radiograph also represents the u6 grade with the appearance of an epiphysis and metaphysis of the same width but no narrowing of the medial physeal plate ( white arrow ) . examiners should focus on the lateral side capping ( red arrow ) . note the hooklike structure / sharp outgrowth at the lateral physis facing the metaphysis that deviates from the physeal line . , the ulna is graded u7 as there is narrowing of the medial physeal plate ( black arrow ) but incomplete fusion . generally , grading of u1 to u4 was not difficult due to some distinct features such as the size of the epiphysis for u3 and the appearance of the styloid for u4 . the difficulties were noted for descriptions in u5 to u8 . for u5 ( fig . 4 ) , the appearance of a denser ulna head was not easily observed and so flattening of the radial half of the ulnar epiphysis was the main determinant . for u6 ( fig . 1 ) , we found that the overlapping of the metaphysis with the epiphysis at the center third was inconsistent in most radiographs , and thus we often relied on the appearance of the epiphysis being as wide as the metaphysis . to differentiate u7 ( fig . 5 ) , we usually used narrowing of the medial ulnar physis ( u7 ) and fusion of the medial ulnar physis ( u8 ) as the determining factor . the descriptions of the smooth curve line articulation in u7 might not be very easily understood . examiners should focus on the flattening of the radial epiphysis ( white arrow ) and should note that the epiphysis is not as wide as the metaphysis , indicated by the vertical white line touching the metaphysis but not the epiphysis . interestingly , the interobserver reliability was somewhat better than the intraobserver reliability , which suggests that the readers may become more competent in the measuring skills with increased grading experience from measuring these 161 radiographs , demonstrating a learning curve effect . hence , this classification scheme should be useful as a guide for decision making and as a communication tool between clinicians . despite not having any prior discussions or training into how each grade should be correctly assessed , the results showed that both examiners used similar grading methods in approaching each radiograph . thus , the difficulties and suggestions raised during the consensus meeting were important to help less experienced examiners with this classification scheme . the dru has been shown to be strongly associated with the peak growth phase and growth cessation,19 which can help clinicians decide between bracing and surgery . the results from this study suggested that the dru classification was a reliable method to assess skeletal growth . although the most appropriate time to get these radiographs still requires further investigation , the authors suggest a yearly radiograph with consideration of radiographs every 6 to 9 months during the period of peak growth spurt . in the future , prospective studies are being developed to apply this classification scheme on patients with ais to determine its sensitivity and specificity in identifying the peak growth spurt , predicting curve deterioration , as well as detecting skeletal maturity . in addition , it can be used to help decide the appropriate timing for initiation and cessation of bracing , when to use growth guidance surgery , and when to recommend fusion . by more accurately predicting a child 's remaining growth potential , we can potentially narrow the duration of effective bracing without jeopardizing the deformity control , thereby reducing any unnecessary psychological burden.23 this knowledge could also guide the duration and interval of follow - up and the number of x - rays needed , thus reducing radiation exposure . additional studies are needed to validate this dru classification in other ethnicities and populations and to further directly compare it with other new and established skeletal maturity schemes.24 
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  this study has shown that the dru classification is a reliable tool for measuring skeletal growth . further prospective studies are required to test its predictability of peak growth spurt and growth cessation and to compare it with other skeletal growth measures such as the risser sign , tw3 grading , and age of menarche .
study design  prospective radiographic study . 
 objective  to test the reliability of the distal radius and ulna classification ( dru ) . 
 methods  this single - center study included prospectively recruited subjects with adolescent idiopathic scoliosis managed with bracing . 
 the left - hand radiographs were measured using the dru classification by two examiners . 
 intra- and interobserver reliability analysis were performed using intraclass correlation ( icc ) analysis . 
 results  from these clinics , 161 patients ( 124 females and 37 males ) with left - hand radiographs were included in the study . the mean age was 13.3 years ( standard deviation : 1.5 ) . 
 there was excellent intra- ( icc : 0.93 to 0.95 ) and interobserver ( icc : 0.97 ) reliability . 
 conclusions  the dru classification scheme has been shown to be accurate in determining the peak growth phase and growth cessation . it has now been confirmed to be a reliable tool . 
 future prospective studies should be performed to investigate its application in deciding when to apply bracing or operative treatment .