sexuality in women is a complex issue with physiological , psychological , and cultural components . determination of sexual partner involvement , intimate relationships , and past abusive relationships is crucial in female sexual dysfunction ( fsd ) ( 1 , 2 ) . sexual dysfunction is more prevalent among women compared to men ( 43% vs. 31% ) ( 3 - 5 ) . in 1960 , masters and johnson studied and reported both on healthy sexual function and sexual dysfunction for the first time . they described four phases of the human sexual response cycle , as follows : excitement , plateau , orgasm , and resolution . nowadays , the accepted classification of fsd consists of disturbances in desire , including hypoactive sexual desire disorders ( hsdd ) , sexual aversion disorders , sexual arousal disorders , orgasmic disorders , and sexual pain disorders , including dyspareunia and vaginismus ( 3 , 6 - 9 ) . fsd can further be classified as primary or secondary and persistent or situational ( 10 ) . intimate sexual function is one of the best predictors of quality of life , and sexual dysfunction causes many problems for couples . some researchers have found that the frequency of sexual relationship and sexual satisfaction are positively associated with marital satisfaction ( 11 , 12 ) . among other factors , illicit drug dependency changes . moreover , opioids act on a variety of neurotransmitters in the brain , including endorphins . furthermore , morphine has been found to inhibit sexual behavior in a dose - dependent manner through a complex pharmacological domain ( 13 , 14 ) . , most studies on drug abuse and sexual performance have focused on addicted populations , and have usually considered men . although many studies have looked at the frequency of sexual dysfunction in women , limited research has focused on the impact of addiction on spouse sexual function . to the best of our knowledge , few studies have been conducted on the effect of males opium dependency on their wives sexuality . thus , the present cross - sectional study aimed to assess the prevalence of fsd among women with addicted partners . we hypothesized that substance dependency in males would affect their wives sexual function . this cross - sectional controlled study was conducted on 340 women of reproductive age ( 25 - 50 years old ) selected through convenience sampling . the case group included 160 women whose husbands were opioid dependent . some of them were the wives of opioid - dependent males hospitalized in the addiction treatment units of teaching hospitals affiliated with the shiraz university of medical sciences , shiraz , iran . other women were encountered in centers where opioid - dependent males spouses were referred for group therapies . in contrast , the control group ( n = 160 ) included women whose spouses were not opioid dependent ; they were selected from the general population referring to the clinics of the shiraz university of medical sciences . after giving informed consent , the participants were interviewed privately according to the dsm - iv - tr criteria by a senior female medical student who was one of the researchers and had been properly trained regarding the nature of the study . the interview focused on hsdd , sexual arousal disorder , orgasmic disorder , and sexual pain disorder . in addition , the subjects demographic information , such as age , level of education , marital status , and duration of marriage , was obtained using a self - constructed questionnaire designed by the authors . to include the women in the study the exclusion criteria of the study were a history of substance use disorders , gynecological disorders ( gyn ) , and chronic medical disease that has been shown to affect sexual functioning ( e.g. hypertension , diabetes mellitus , chronic kidney disease , cancer , spinal cord injury , lupus , fibromyalgia , chronic pain and chronic depression ) . it should be noted that the questionnaires were anonymous and participation in the study was voluntary . the chi - square test was used for categorical data , while the t - test was utilized for continuous data . the protocol for this study was approved by the ethics committee of the shiraz university of medical sciences , shiraz , iran . out of the 340 women who were selected , 5 in the case group and 15 in the control group were excluded due to missing data . the mean ages of the case and the control group were 36.35 and 33.2 years , respectively . in this study , statistical significance was defined as p < 0.05 . it should be noted that in terms of demographic characteristics , there was no significant difference between the case and the control group ( p > 0.05 ) , so , we could use further statistical methods on the data . table 2 shows the frequency of sexual dysfunction in the two study groups . according to the results , approximately more than 50% of the participants had problems in at least one domain of sexual function . moreover , the main fsd observed in the case women was hsdd ( 75.46.9% ) followed by sexual aversion disorder ( 73.46.2% ) , sexual arousal disorder ( 65 .40.9% ) , orgasmic disorder ( 59.37.1% ) , and sexual pain disorder ( 45.28.5% ) . furthermore , 75 out of the 155 women in the case group ( 46.9% ) and 16 out of the 145 women in the control group ( 10% ) had hsdd , and the difference between the two groups was statistically significant ( p < 0.05 ) . in addition , 73 women in the case group ( 46.2% ) and 20 in the control group ( 12.6% ) had sexual aversion disorder , with a significant difference between the two groups ( p < 0.05 ) . in this study , this disorder was a significant problem affecting a considerable number of women in both the case and control groups ( table 2 ) . this high prevalence may have resulted from various causes . although studies have shown that many factors , such as age and level of education , affect sexual function ( 15 - 17 ) , the findings of the current study revealed no relationship between the demographic characteristics , that is , age , duration of marriage , and level of education , and sexual dysfunction . as can be seen in table 2 , the frequency of hsdd and aversive sexual desire disorder was more common in the case group than the control group , and the difference was statistically significant ( p < 0.05 ) . the high frequency of hsdd among the addicts spouses exhibited in this study was in line with the study performed by noori et al . however , noori et al . included no control groups in their study , and consequently , it was not possible to compare the characteristics of the subjects with those of women whose husbands were not addicted . the findings of the present study showed that the addicts spouses suffered from hsdd significantly more than the control group . another finding was the higher frequency of orgasmic disorder in the case group ; however , this difference was not statistically significant . the higher rate of orgasmic disorder among the addicts spouses obtained in this research was in line with the study by noori et al . in contrast to our research , in one study conducted on 2626 women in iran in 2006 , 31.5% of the subjects ( 759 ) suffered from sexual disorder , and the most prevalent disorder was orgasmic disorder , followed by desire disorder ( 19 ) . in the dsm - iv - tr , sexual desire disorders are divided into two classes , as follows : 1 ) hsdd characterized by a deficiency or lack of sexual fantasies and desire for sexual activity and 2 ) sexual aversion disorder characterized by an aversion to and avoidance of genital contact with a sexual partner . no single cause of hsdd has been defined ; however , physiological , psychological , and sociocultural factors that contribute to female sexual desire may all be important in its development ( 20 , 21 ) . master and johnson s linear model of sexual response does not always work for females . some factors , such as emotional intimacy and relationship satisfaction , may change this model . studies have shown that the motivating factors for female sexual desire are very complicated . sexual desire and the presence or absence of orgasm could result from multiple cultural and environmental factors , as well as from interpersonal and intrapersonal distresses , and are greatly affected by emotional intimacy ( 2 ) . since addiction in the family could be the origin of many stressors and disputes , such stresses and interpersonal turmoil could have a decisive role in decreasing females sexual desire toward their addicted husbands . researchers have found that sexual response phases in women are a combination of mental and physical responses which overlap with one another ( 2 , 3 ) . in general , women have diverse reasons to initiate or agree to have sex with their partners . sexual motivation in females is far more complicated than just the presence or absence of sexual desire and is characterized by thinking or fantasizing about sex and longing to have sex . moreover , the decision to be sexual may originate from a conscious wish for emotional closeness or result from seduction or a suggestion from a partner . addicted couples often have conflicts over money and drugs ; so that love gradually flies out of the window , and most often these couples relationships end at a sad , bitter point ( 11 , 22 , 23 ) . hence , this kind of relationship is expected to have a negative impact on sexuality . of course , further studies are needed in order for better characterization and understanding of fsd epidemiology . one of the limitations of this study was the difficulty of gaining access to the case group sample and persuading them to cooperate with the researchers . in addition , when they agreed to take part in the study , the interviewer had to meet them out of their group . moreover , the subjects might have answered the questions conservatively due to the particular nature of the study subject , that is , sexual behavior , in iranian culture . another limitation of the study was a lack of control of other contributing factors , such as the economic status of the family and sexual disorders and duration of opioid dependency in addicted husbands , which are assumed to have an effect on their wives sexual dysfunctions .
backgroundopiate abuse in males has significant effects on their sexual functions . 
 in contrast , sexuality in females is a multidimensional issue that can strongly be affected by several factors in their partners . 
 however , only a limited number of studies have assessed the role of males opioid dependency in their female partners sexual function.objectivesthe present study aimed to evaluate the effect of males opioid dependency on their wives sexual function compared to the sexual function of the females whose husbands were not opioid dependent.patients and methodsthis study included 340 women who were selected through convenience sampling and divided into a control ( females whose husbands were not opioid dependent ) and a case group ( women whose husbands were opioid dependent ) . 
 the data were collected through an interview according to the dsm - iv - r criteria for female sexual dysfunctions by a senior female medical student who was one of the researchers . 
 finally , the data were entered into the spss statistical software ( v. 15 ) and analyzed using the t - test and chi - square test.resultsaccording to the results , the frequency of hypoactive sexual desire disorder and sexual aversion disorder in the control group was significantly higher than that of the case group ( p < 0.05).conclusionsthe results showed that having an addicted husband could strongly affect some sexual domains in women . 
 it could change the pattern of desire and motivation for sexual contact in females and alter their attitude toward the sexual relationship , thereby causing disturbances in the females normal sexual function .