advancing age is related to considerable changes in mental and physical health , including loss of muscle mass ( sarcopenia ) and muscle function . this can lead to impaired physical ability and reduced quality of life.13 after the age of 70 years , about 1.5% of muscle mass is lost per year.4 denervation , metabolic , hormonal , or immunological reasons and the reduction of physical activity , in particular , contribute to sarcopenia.5 however , muscles can maintain a high degree of plasticity in advanced age , whereas tendons lose their plasticity predisposing them to injuries.6 resistance training may reverse tendon stiffness and reduce the risk of strain injuries . furthermore , it can increase muscle strength and improve mobility as well as physical functioning in the elderly.7 several studies have investigated exercise programs for the very elderly and found moderate to very high improvements in muscle strength , balance , gait speed , and other outcomes that are indispensable for an independent life.810 however , most studies examined healthy and community dwelling elderly,1113 whereas persons with impaired physical ability as well as nursing - home residents or persons in long - term care facilities were underrepresented.14 a recent systematic review on the effects of progressive resistance training in elderly nursing - home residents showed that the intensity of the training should be vigorous and the duration at least 2 months.15 most authors describe a frequency of three training sessions per week , but the optimal frequency has not been defined.1619 therefore , the aim of this study was to investigate how much progressive strength training twice a week over a period of 8 weeks improves mobility , muscle strength , and quality of life in nursing - home residents with impaired mobility aged 75 years and older . between may and july 2009 , 34 nursing homes in berlin were contacted by phone . out of the twelve that agreed to have a personal meeting with more detailed information , seven homes were excluded due to lack of interest in participation , residents without impaired mobility , or residents were looked after by a legal guardian . nursing - home residents were included if they fulfilled all of the following criteria : ( 1 ) 75 years of age and older ; ( 2 ) mild to severely impaired mobility defined as an elderly mobility scale ( ems ) score between six and 18 points ; ( 3 ) sufficient language skills ; ( 4 ) written informed consent ; and ( 5 ) written consent by their general practitioner . exclusion criteria were : ( 1 ) moderate to severe dementia ( mini - mental state examination < 18 points;20 ( 2 ) rheumatologic , orthopedic , or any other condition that could be aggravated by sport ; ( 3 ) elevated systolic / diastolic blood pressure during exercise ( > 230/110 mmhg ) ; ( 4 ) cardiac arrhythmia ; ( 5 ) epilepsy ; or ( 6 ) legal care . the ethical review committee of the charit university medical center ( berlin , germany ) approved the study . participants underwent a progressive resistance training program twice a week for 8 weeks using the following six gym machines : chest press , rowing machine , and butterfly reverse for the upper limb , leg press and leg extension for the lower limb , and a crunch trainer for the abdominals ( gym80 international gmbh , gelsenkirchen , germany ) . training was performed in three sets of eight repetitions of the individual lifted weight . between the sets , participants had to pause for at least 1 minute . , all participants received an individual detailed introduction at each gym machine by qualified fitness trainers . the 15 participants were divided into two groups , which trained separately and were supervised by the trainers and the study investigator throughout the program . at each machine , height and angle of the seat participants who needed help to get on the seat were supported by the training staff . sitting height and position as well as velocity and range of movements at each machine the lifted weight was set by the training staff , documented , and regularly adapted to the augmented muscle strength of participants . as soon as a participant could lift the weight more than eight times in a row in all of the three sets , the weight was increased to the next level . primary outcome of the study was the change in mobility determined by the standardized and validated ems , a seven - item instrument with a good sensitivity and practicability , assessed by the study physician . the score ranges from zero ( minimal mobility ) to 20 ( maximal mobility).2123 secondary outcomes were changes in muscle strength and quality of life . muscle strength was measured indirectly by documenting the respective lifted weight . for the assessment of quality of life , the short form-36 health survey ( sf-36 ) was used.24 all participants underwent a short medical exam including a resting electrocardiogram in the department of sports medicine at the charit university medical center . in the gym , the trainers determined the individual eight - repetition maximum , defined as the highest weight that a participant can lift a maximum of eight times in a row . it is comparable to 80% of the one - repetition maximum ( the highest weight a person can lift only once ) . the latter was not used due to a higher risk of causing blood pressure peaks in comparison to the eight - repetition maximum . during this introductory exercise , blood pressure was measured after every weightlifting series at each machine to detect potential blood pressure peaks . all participants received a free 3-monthly membership for the gym including insurance , which covered possible accidents occurring during the stay at the gym . during transportation from the nursing home to the gym , they were insured by a private transportation company . a pre  post comparison of assessed outcomes ( mean  standard deviation ) was carried out by the wilcoxon signed - rank test for paired samples . the alpha - type error was set at 0.05 , with a power of 80% . data analysis was conducted with spss 12.0.0 ( spss inc , chicago , il , usa ) . the outcome variables mobility and muscle strength were assessed as continuous variables from zero ( minimum ) to 20 ( maximum ems score ) and lifted weight in kilograms , respectively . between may and july 2009 , 34 nursing homes in berlin were contacted by phone . out of the twelve that agreed to have a personal meeting with more detailed information , seven homes were excluded due to lack of interest in participation , residents without impaired mobility , or residents were looked after by a legal guardian . nursing - home residents were included if they fulfilled all of the following criteria : ( 1 ) 75 years of age and older ; ( 2 ) mild to severely impaired mobility defined as an elderly mobility scale ( ems ) score between six and 18 points ; ( 3 ) sufficient language skills ; ( 4 ) written informed consent ; and ( 5 ) written consent by their general practitioner . exclusion criteria were : ( 1 ) moderate to severe dementia ( mini - mental state examination < 18 points;20 ( 2 ) rheumatologic , orthopedic , or any other condition that could be aggravated by sport ; ( 3 ) elevated systolic / diastolic blood pressure during exercise ( > 230/110 mmhg ) ; ( 4 ) cardiac arrhythmia ; ( 5 ) epilepsy ; or ( 6 ) legal care . the ethical review committee of the charit university medical center ( berlin , germany ) approved the study . participants underwent a progressive resistance training program twice a week for 8 weeks using the following six gym machines : chest press , rowing machine , and butterfly reverse for the upper limb , leg press and leg extension for the lower limb , and a crunch trainer for the abdominals ( gym80 international gmbh , gelsenkirchen , germany ) . training was performed in three sets of eight repetitions of the individual lifted weight . between the sets , participants had to pause for at least 1 minute . , all participants received an individual detailed introduction at each gym machine by qualified fitness trainers . the 15 participants were divided into two groups , which trained separately and were supervised by the trainers and the study investigator throughout the program . at each machine , height and angle of the seat participants who needed help to get on the seat were supported by the training staff . sitting height and position as well as velocity and range of movements at each machine the lifted weight was set by the training staff , documented , and regularly adapted to the augmented muscle strength of participants . as soon as a participant could lift the weight more than eight times in a row in all of the three sets , the weight was increased to the next level . primary outcome of the study was the change in mobility determined by the standardized and validated ems , a seven - item instrument with a good sensitivity and practicability , assessed by the study physician . the score ranges from zero ( minimal mobility ) to 20 ( maximal mobility).2123 secondary outcomes were changes in muscle strength and quality of life . muscle strength was measured indirectly by documenting the respective lifted weight . for the assessment of quality of life , the short form-36 health survey ( sf-36 ) was used.24 all participants underwent a short medical exam including a resting electrocardiogram in the department of sports medicine at the charit university medical center . in the gym , the trainers determined the individual eight - repetition maximum , defined as the highest weight that a participant can lift a maximum of eight times in a row . it is comparable to 80% of the one - repetition maximum ( the highest weight a person can lift only once ) . the latter was not used due to a higher risk of causing blood pressure peaks in comparison to the eight - repetition maximum . during this introductory exercise , blood pressure was measured after every weightlifting series at each machine to detect potential blood pressure peaks . all participants received a free 3-monthly membership for the gym including insurance , which covered possible accidents occurring during the stay at the gym . during transportation from the nursing home to the gym , a pre  post comparison of assessed outcomes ( mean  standard deviation ) was carried out by the wilcoxon signed - rank test for paired samples . the alpha - type error was set at 0.05 , with a power of 80% . data analysis was conducted with spss 12.0.0 ( spss inc , chicago , il , usa ) . the outcome variables mobility and muscle strength were assessed as continuous variables from zero ( minimum ) to 20 ( maximum ems score ) and lifted weight in kilograms , respectively . fifteen nursing - home residents aged 7797 years ( mean age 84 years ) were recruited . in the current analysis , ten participants who completed the 8-week program were included : four men ( mean age 88 years , range 8095 years ) and six women ( mean age 81 years , range 7787 years ) . during the course of the 8 weeks , three men and two women dropped out of the study for the following reasons : back pain , which was not related to the intervention ; depression ; insufficient adjustment of insulin therapy to the exercise program ; broken foot ( at the nursing home ) ; ripped catheter during changing of clothes before the training . the five participants who dropped out were comparable in age , sex , and body mass index to the ten participants who completed the 8 weeks of intervention , with an average of 15/16 completed sessions ( table 1 ) . after the 8-week intervention , mobility improved by 24% ( p = 0.005 ; table 2 ) . the effect was larger in men compared to women ( 27% versus 21% ) : baseline ems scores of 14 versus 18 and 15 versus 18 after 8 weeks for men and women , respectively . muscle strength ( eight - repetition maximum ) increased at every machine ( table 2 ) . at the rowing machine and the leg extension machine , the number of sit - up repetitions increased fourfold ( pre 10.5  3.1 , post 41.7  12.1 repetitions ; p = 0.027 ) . women showed a higher improvement in the eight - repetition maximum , particularly at the rowing machine and leg extension ( figure 2 ) . after the 8-week training program , quality of life did not change considerably regarding both the physical and emotional sum scales of the sf-36 : pre 30/100 , post 30/100 and pre 59/100 , post 56/100 ( p = 0.29 ) , respectively . there were also no relevant improvements regarding the subscales of the sf-36 except for the subscale of physical functioning , which slightly improved ( pre 27/100 , post 32/100 ; p = 0.54 ) . fifteen nursing - home residents aged 7797 years ( mean age 84 years ) were recruited . in the current analysis , ten participants who completed the 8-week program were included : four men ( mean age 88 years , range 8095 years ) and six women ( mean age 81 years , range 7787 years ) . during the course of the 8 weeks , three men and two women dropped out of the study for the following reasons : back pain , which was not related to the intervention ; depression ; insufficient adjustment of insulin therapy to the exercise program ; broken foot ( at the nursing home ) ; ripped catheter during changing of clothes before the training . the five participants who dropped out were comparable in age , sex , and body mass index to the ten participants who completed the 8 weeks of intervention , with an average of 15/16 completed sessions ( table 1 ) . after the 8-week intervention , mobility improved by 24% ( p = 0.005 ; table 2 ) . the effect was larger in men compared to women ( 27% versus 21% ) : baseline ems scores of 14 versus 18 and 15 versus 18 after 8 weeks for men and women , respectively . muscle strength ( eight - repetition maximum ) increased at every machine ( table 2 ) . at the rowing machine and the leg extension machine , the number of sit - up repetitions increased fourfold ( pre 10.5  3.1 , post 41.7  12.1 repetitions ; p = 0.027 ) . women showed a higher improvement in the eight - repetition maximum , particularly at the rowing machine and leg extension ( figure 2 ) . after the 8-week training program , quality of life did not change considerably regarding both the physical and emotional sum scales of the sf-36 : pre 30/100 , post 30/100 and pre 59/100 , post 56/100 ( p = 0.29 ) , respectively . there were also no relevant improvements regarding the subscales of the sf-36 except for the subscale of physical functioning , which slightly improved ( pre 27/100 , post 32/100 ; p = 0.54 ) . this pilot study represents an approach to the development of an exercise program focused on the elderly . the progressive resistance program with two sessions per week over a period of 8 weeks improved mobility and muscle strength in nursing - home residents over 75 years of age with impaired mobility . this study showing that progressive resistance training increases muscle strength confirmed results from previous studies such as the randomized controlled trial by ferri et al who trained participants aged 6581 years at 80% of the one - repetition maximum with knee extension machines . the one - repetition maximum increased as well as the cross - sectional muscle area.25 rosendahl et al showed positive effects of 3 months resistance training ( eight to twelve - repetition maximum ) in participants with a mean age of 84 years , which were still present after 6 months.26 resistance training programs for nursing - home residents with a high - intensity program ( eight - repetition maximum or 80% of the one - repetition maximum ) , as used in the current study , seem to be the most effective method to increase muscle strength.15,1719,26,27 however , the strong positive effect in muscle strength improvement shown in the current study was in accordance with only one of these studies,17 whereas the other studies showed smaller effects on muscle strength.18,19,26 regarding training frequency , sessions offered three times a week were used most often in studies focusing on the elderly.14,15 in contrast to this approach , the current study examined a training program with only two sessions per week and was able to show even stronger effects than in comparable studies.27,28 training duration did not seem to have a comparable influence as training intensity . latham et al showed an effect size difference of 0.15 between short ( 12 weeks ) and long training duration ( > 12 weeks ) in 41 trials with 1955 participants aged 60 years and over.14 as in the current study , most interventions had a duration of 812 weeks.18,19,27,29 progressive resistance training improves not only muscle strength and mobility but also physical abilities , including simple and more complex daily activities in the elderly . however , there is insufficient evidence on long - term effects as concluded by the authors of a cochrane review.30 overall quality of life , shown with the physical and emotional sum scale of the sf-36 , did not improve in the current study . it is assumed that the 8-week duration of the intervention was too short to detect considerable changes in quality of life . furthermore , the structure of the sf-36 may have been too complex for this age group ( eg , heterogeneity of answering categories ) . interviews had to be conducted with some participants who were not able to read the questionnaire by themselves . a shorter questionnaire with simpler answering categories such as the sf-12 may be an alternative to assess quality of life in future studies with the elderly.31 a particular feature of this study was the investigation of very elderly nursing - home residents with impaired mobility who have hardly been included in intervention studies as shown by the review of valenzuela.15 a strength of this study was the use of validated instruments like the ems and the sf-36.22,24 several potential limitations have to be considered when interpreting the results of this pilot study . due to the lack of a control group , the possibility that other factors in addition to the resistance program contributed to the improved mobility and muscle strength can not be ruled out . furthermore , familiarization with the gym equipment may have contributed to the training effect , since most participants were not used to resistance training in a gym . the small study population of this investigation can not be considered as representative for nursing - home residents in berlin . . for safety and legal considerations , several inclusion and exclusion criteria had to be defined in order not to put participants at risk and aggravate preexisting diseases . persons under legal care ( about 80% of nursing - home residents ) were not eligible and were therefore not included in the study . although several study participants dropped out , two - thirds completed the 8-week intervention , showing the feasibility of this resistance program in persons up to almost 100 years of age with impaired mobility . this pilot study represents an approach to the development of an exercise program focused on the elderly . the progressive resistance program with two sessions per week over a period of 8 weeks improved mobility and muscle strength in nursing - home residents over 75 years of age with impaired mobility . this study showing that progressive resistance training increases muscle strength confirmed results from previous studies such as the randomized controlled trial by ferri et al who trained participants aged 6581 years at 80% of the one - repetition maximum with knee extension machines . the one - repetition maximum increased as well as the cross - sectional muscle area.25 rosendahl et al showed positive effects of 3 months resistance training ( eight to twelve - repetition maximum ) in participants with a mean age of 84 years , which were still present after 6 months.26 resistance training programs for nursing - home residents with a high - intensity program ( eight - repetition maximum or 80% of the one - repetition maximum ) , as used in the current study , seem to be the most effective method to increase muscle strength.15,1719,26,27 however , the strong positive effect in muscle strength improvement shown in the current study was in accordance with only one of these studies,17 whereas the other studies showed smaller effects on muscle strength.18,19,26 regarding training frequency , sessions offered three times a week were used most often in studies focusing on the elderly.14,15 in contrast to this approach , the current study examined a training program with only two sessions per week and was able to show even stronger effects than in comparable studies.27,28 training duration did not seem to have a comparable influence as training intensity . latham et al showed an effect size difference of 0.15 between short ( 12 weeks ) and long training duration ( > 12 weeks ) in 41 trials with 1955 participants aged 60 years and over.14 as in the current study , most interventions had a duration of 812 weeks.18,19,27,29 progressive resistance training improves not only muscle strength and mobility but also physical abilities , including simple and more complex daily activities in the elderly . however , there is insufficient evidence on long - term effects as concluded by the authors of a cochrane review.30 overall quality of life , shown with the physical and emotional sum scale of the sf-36 , did not improve in the current study . it is assumed that the 8-week duration of the intervention was too short to detect considerable changes in quality of life . furthermore , the structure of the sf-36 may have been too complex for this age group ( eg , heterogeneity of answering categories ) . interviews had to be conducted with some participants who were not able to read the questionnaire by themselves . a shorter questionnaire with simpler answering categories such as the sf-12 may be an alternative to assess quality of life in future studies with the elderly.31 a particular feature of this study was the investigation of very elderly nursing - home residents with impaired mobility who have hardly been included in intervention studies as shown by the review of valenzuela.15 a strength of this study was the use of validated instruments like the ems and the sf-36.22,24 several potential limitations have to be considered when interpreting the results of this pilot study . due to the lack of a control group , the possibility that other factors in addition to the resistance program contributed to the improved mobility and muscle strength can not be ruled out . furthermore , familiarization with the gym equipment may have contributed to the training effect , since most participants were not used to resistance training in a gym . the small study population of this investigation can not be considered as representative for nursing - home residents in berlin . . for safety and legal considerations , several inclusion and exclusion criteria had to be defined in order not to put participants at risk and aggravate preexisting diseases . persons under legal care ( about 80% of nursing - home residents ) were not eligible and were therefore not included in the study . although several study participants dropped out , two - thirds completed the 8-week intervention , showing the feasibility of this resistance program in persons up to almost 100 years of age with impaired mobility . a progressive resistance training program only twice a week over a period of 8 weeks seems to be a beneficial intervention to improve mobility and muscle strength in nursing - home residents with impaired mobility aged up to 97 years . the intervention did not seem to influence quality of life as assessed by the sf-36 over the 2-month study period ; however , it can not be excluded that a longer intervention may have beneficial effects on quality of life as well . randomized controlled trials evaluating the benefits of resistance training in frail nursing - home residents are urgently needed . in these trials , the setting should be adapted and implementable in the daily routine of the elderly regarding intensity , duration , and frequency of the training ; special attention should be paid to a presumably high dropout rate due to multimorbidity .
purposeto determine the effects of progressive resistance training on mobility , muscle strength , and quality of life in nursing - home residents with impaired mobility.methodsnursing-home residents aged 77 years and older with impaired mobility were recruited in berlin , germany . 
 the eight - week exercise program consisted of progressive resistance training twice a week . 
 mobility ( primary outcome ) was assessed with the elderly mobility scale ( zero = worst , 20 = best ) at baseline and after 8 weeks . 
 muscle strength ( secondary outcome ) was determined by the eight - repetition maximum . 
 the short form-36 health survey was used to assess quality of life.resultsof the 15 participants ( mean age 84 years , range 7797 years ) , ten completed the 8-week program . 
 mobility ( elderly mobility scale mean  standard deviation pre 14.1  3.2 and post 17.5  3.6 ; p = 0.005 ) as well as muscle strength of upper and lower limbs improved ( from 62% at chest press up to 108% at leg extension machine ) , whereas most quality of life subscales did not show considerable change.conclusionresistance training twice a week over 2 months seemed to considerably improve mobility and muscle strength in persons aged 7797 years with impaired mobility .