. however , the real impact appears in those burns that are not fatal , and cause disability , prolonged hospital stays , psychosocial stigmas , and pain.1 the latter is a constant cause of attention because it affects quality of life.2,3 most hospitals try to integrate a multidisciplinary team for the treatment of burn pain . there are two treatment options : pharmacological and nonpharmacological therapy.4 nonpharmacological therapies include psychological techniques to reduce anxiety such as : relaxation , distraction , and cognitive behavioral therapy.46 this approach seeks to reduce the use of drugs , inpatient hospital stay , and pain as well as improve the quality of life without suffering from the side effects that often occur with the use of pharmacological therapy . there are other nonpharmacological options for pain relief from diverse etiologies710 that can complement the treatment following a burn such as transcutaneous electrical nerve stimulation ( tens ) , which is easy to use , has a low - cost , and no serious adverse effects . tens consists of the application of low voltage electric current through electrodes placed on the skin . electrical stimulation reduces pain through central and peripheral mechanisms.7,11 electrostimulation activates , in a selective form , the afferent fibers ( a ) that inhibit the nociceptive information . moreover , the afferent fibers activate the extra - segmental circuit between the spinal cord and the brain that generates the activation of central inhibitory way of pain . the symmetrical biphasic ( faradic)-pulsed currents applied continuously and interruptedly in the same session could generate analgesia and promote healing , respectively . the objective of this research was to assess the effect of continuous and intermittent electrical stimulation on the pain perception in patients with different types of burns . a pilot study was conducted in 14 adults ( 1860 years of age ) , with similar demographic and socioeconomic characteristics who had second- and/or third - degree burns of different types according to american burn association . the inclusion criteria for participation in the study included total body surface area with burns < 50% and the occurrence of the burn being within 24 hours of the beginning of the study . all participants had to be able to answer simple questions and understand the nature of the study . all patients were admitted to the burn unit of centro nacional de occidente a specialties hospital of the mexican institute of social security . patients on mechanical ventilation , without intact skin for electrode placement , pregnant women , and those with psychiatric conditions were excluded from the study . all subjects were informed about the use of electrostimulation , and informed consents were signed by each patient . the local committee of scientific research of the hospital de especialidades approved and accepted the protocol . a visual analog scale was used to assess pain . the scale was graded from 0  no pain  to 10  maximum pain  for assessing pain intensity before and after receiving the electrical stimulation therapy . additionally , a complete physical examination was performed to calculate the total body surface area burned and its depth . electrotherapy was given through a portable device , the sinapsis 4.0 ( zerta technologies , guadalajara , mxico ) that has output parameters that are different from the other available tens modalities . it generates automatically a biphasic waveform current with a continuous mode ( 15 minutes ) and an intermittent mode ( 15 minutes ) . the current intensity was 40 ma , nonpolar and frequency of 80100 hz . the specific waveform current avoids muscular contractions . the device has four channels and delivers the electrical stimulus via eight electrodes placed on the skin . rectangular ( 510 cm ) flexible electrodes with a silver and coal conductive layer were used ( pepin manufacturing , inc . , lake city , mn , usa ) . the electrotherapy sessions were performed three times per week ( monday to friday ) for 4 weeks . the position of electrodes over the skin was different in each patient according to the localization of the burn . the results of clinical characteristics are presented in mean , standard deviation , and ranges . wilcoxon s rank - sum test was used for analyzing changes in the pain visual analog scale . a significant p - value of 0.05 ( two - tailed ) was considered statistically significant . all statistical analyses were calculated using spps software 17th version ( ibm , corporation , armonk , new york , usa ) . a total of 14 hospitalized patients ( female : male , 1:13 ) were enrolled in the study and completed all the sessions . after the intervention a statistically significant reduction in pain perception ( p=0.027 ; 8.01.7 vs 1.00.5 ) was observed ( table 2 ) . the nurse team reported a long time analgesic effect on patients after the electrical intervention , but we could not measure this observation effectively . the length of hospital stay was variable for each patient , being longer for patients who had burns with greater thickness . early and efficient management of pain can have a big impact on the quality of the patient s life . the mechanism by which pain is produced in burn patients may be due to the inflammatory response generated , primary hyperalgesia , or mechanical stimulation of nociceptive receptors at the site of injury , secondary hyperalgesia.12 electrical stimulation can reduce pain through central and peripheral mechanisms . the central mechanism includes activation of the opioid , muscarinic , and serotonin receptors in the spinal cord and brainstem . peripherally , at site of tens application , the reduction of pain may be through activation of the opioid and -2 adrenergic receptors involved in analgesia.13 this mechanism of action is similar to the pharmacological treatment used for analgesia and sedation in intensive care units , but without the known side effects of these drugs.14 tens reduces pain without the presence of adverse effects . it does not involve any risk for the burn patient because electrodes are placed on the periphery of the injured skin . it also represents a low - cost option.8 in addition to the benefit of reducing pain , electrical stimulation can accelerate wound healing by promoting greater cell migration to the site of injury;12 by this means , it could reduce number of days of hospital stay and overall costs.15 the main limitations of the present study were its design , the lack of a comparison group , and the small sample size . however , despite the different types of burns , a significant decrease in pain was observed in all patients and this protocol opens up the possibility to use other therapies for pain management in burn patients . electrical stimulation could be a potential nonpharmacological therapeutic option for pain management in burn patients . however , a controlled clinical trial with a bigger sample size and the use of a stratified analysis according to the different etiologies of burns is needed .
aimthe aim of this study was to assess the effect of continuous and intermittent electrical transcutaneous nerve stimulation on the perception of pain in patients with burns of different types.materials and methodsa pilot study was conducted in 14 patients ( age 30.97.5 years ) with second- and third - degree burns of different types . 
 the burn types included electrical , fire / flame , and chemical . 
 all patients received continuous and intermittent electrical transcutaneous nerve stimulation sessions three times per week for 4 weeks . 
 each session had a duration of 30 minutes . 
 a pair of electrodes were placed around the burn . 
 the primary efficacy endpoint was the perception of pain assessed by a visual analog scale at baseline and at the 30th day.resultsa significant reduction of pain perception was reported ( 8.01.7 vs 1.00.5 ; p=0.027 ) by all patients after electrical stimulation therapy . 
 there were no reports of adverse events during the intervention period.conclusionelectrical stimulation could be a potential nonpharmacological therapeutic option for pain management in burn patients .