lung cancer is the second most common cancer in both men and women with an estimated 224,210 cases expected to be diagnosed in 2014 in the united states ( us ) . it is also the leading cause of cancer related deaths in the us accounting for 27% of all cancer related deaths . the majority of lung cancer cases fall under the category of non - small - cell lung cancer ( nsclc ) . figure 1 shows the selection of the non - small - cell lung cancer cases included in the study . racial / ethnic disparities have been shown to influence survival outcomes in nsclc [ 24 ] . disparities in survival outcomes among racial / ethnic groups may be attributed to a complex interaction between genetic and lifestyle factors [ 4 , 5 ] . compared to non - hispanic whites ( nhw ) , blacks have a higher incidence of lung cancer and more advanced disease at diagnosis with worse survival outcomes [ 68 ] . despite a lower incidence , hispanics are more likely to be diagnosed with advanced disease with poor outcomes compared to nhw [ 2 , 9 ] . asian / pacific islanders ( api ) have a lower incidence of nsclc compared to nhw . interestingly , previous literature has shown that cancer related mortality is favorable in api compared to other racial / ethnic groups for early stage ( stages ia and ib ) nsclc [ 11 , 12 ] . however , survival outcomes in api and other racial / ethnic groups based on the recently published american joint committee on cancer ( ajcc ) 7th edition have not been evaluated in detail . in this study , our primary objective was to utilize an established large nationwide cancer registry to ascertain racial / ethnic disparities in nsclc clinicopathologic features and survival outcomes . we used the national cancer institute ( nci ) surveillance , epidemiology , and end result ( seer ) cancer registry that collects large observational data across 18 cancer registry sites . the database was accessed using the seerstat 8.1.5 , http://seer.cancer.gov/seerstat , assessed may 01 , 2014 . to be eligible , we identified patients diagnosed between 01/01/2004 to 31/12/2010 with nsclc ( icd - o-3 site c34.0c34.9 ) based on the selected histology codes : squamous and transitional cell : 8051 - 8052 , 80708084 , and 81208131 , adenocarcinoma in situ [ ais ] : 82508255 , nonadenocarcinoma in situ [ non - ais ] : 8050 , 81408149 , 81608162 , 81908221 , 82568263 , 82708280 , 82908337 , 83508390 , 84008560 , 85708576 , and 8940 - 8941 , large cell : 80118015 , and  others  : 8010 , 80208022 , 80308040 , 8046 , 80908110 , 81508156 , 81708175 , 8180 , 8230 - 8231 , 82408249 , 83408347 , 8561 - 8562 , and 85808671 . we utilized the time period stated , due to the ability to restage the tumors to the latest ajcc 7th edition using data from the collaborative stage variables . to investigate any existing treatment or tumor racial / ethnic disparities and disease - specific survival ( dss ) , racial / ethnic groups were categorized as nhw , hispanics , blacks , and api . clinicopathologic characteristics included age at diagnosis , gender , birth country , marital status , tumor grade , tumor size , ajcc stage , and histology . decade long time intervals  < 30 years ,   3039 ,   4049 ,   5059 ,   6069 ,   7079 , others ,  a term that is inclusive of divorced , widowed , or separated individuals . birth within the us or outside was used to monitor  the immigration effect . the variable  tumor size  reflected the size of the tumor mass and was classified categorically to < 30  mm  ,  3050  mm  ,  5070  mm  , > 70  mm  or in cases with no recorded tumor mass to  no mass was found  . all forms of radiation were collectively grouped as  radiation received ,  while all forms of cancer directed surgeries were coded collectively as cases after 2010 were excluded to allow a minimum of 12 months of follow - up period . the kruskall - wallis nonparametric test was employed to examine the differences that may exist among various racial / ethnic groups and tumor characteristics . the difference between the racial / ethnic groups and the reasons for no surgery was measured using fisher 's exact test . the end point was dss which was measured in months from the date of diagnosis to death due to lung cancer or censoring , which included either being alive , lost to follow - up , or died due to other causes . multivariate cox proportional hazard models were used to establish the weight of different characteristics ( grade , age at diagnoses , tumor size , histology , marital status , race / ethnicity , gender , radiation , surgery , and radiation / surgery sequence ) on prognostic significance contributing to the survival in each respective ajcc stage . the z test was employed to examine the proportional differences that may exist between the referent nhw and other race / ethnic groups . the models were constructed using ibm spss statistical software , version 21.0 ( ibm corp . released 2012 , ibm spss statistics for windows , version 21.0 , armonk , ny : ibm corp . ) . our database yielded 190,046 patients with nsclc : 145646 ( 76.6% ) nhw , 10350 ( 5.4% ) hispanics , 22525 ( 11.9% ) blacks , and 11525 ( 6.1% ) api ( table 1 ) . compared to nhw stage i diagnosis ( 17.8% ) , blacks had the least proportion ( 12.4% ) preceded by hispanics ( 13.5% ) and api ( 14.3% ) ( p < 0.05 ) . nhw had the most stage ii diagnosis ( 13.1% ) , followed by blacks ( 12.7% ) , api ( 11.7% ) , and hispanics ( 11.4% ) ( p < 0.05 ) . blacks had the highest stage iii diagnoses ( 20.5% ) , followed by the referent nhw ( 18.5% ) , hispanics ( 17.7% ) , and api ( 17.2% ) ( p < 0.05 ) . api had the highest stage iv diagnoses ( 49.3% ) , followed by hispanics ( 47.7% ) , blacks ( 47.4% ) , and the referent nhw ( 42.6% ) , respectively . compared to the referent nhw 's grades 1 ( 5.0% ) and 2 ( 16.5% ) statuses , blacks had the least amount of grade 1 ( 3.3% ) and grade 2 ( 14.8% ) tumors , while hispanics ( 5.4% ) and api ( 5.7% ) both had relatively greater grade 1 representations , respectively ( p < 0.05 ) . regarding high grade tumors , api had significantly the lowest proportions of both grade 3 ( 25.7% ) and grade 4 ( 1.8% ) cases , compared to nhw . hispanics also had lower grade 3 ( 26.8% ) diagnoses , compared to nhw , while blacks had greater proportions ( 28.2% ) . squamous and transitional cell diagnoses were significantly less common in api ( 15.8% ) and hispanics ( 19.2% ) compared to nhw ( 23.6% ) ( p < 0.05 ) . although blacks had greater shares ( 24.1% ) , this was nonsignificant . compared to nhws ' ais ( 4.1% ) and non - ais ( 38.3% ) histological diagnoses , hispanics had greater proportions ( 5.0% and 41.9% ) , with api having the greatest representation ( 6.3% and 49.6% ) . alternatively , blacks yielded the fewest ais ( 2.8% ) cases in our study ( p < 0.05 ) . for large cell carcinoma in the referent group ( 3.4% ) , both api ( 2.5% ) and hispanics ( 3.0% ) ranked lower , while a greater share was found among blacks ( 4.1% ) ( p < 0.05 ) . compared to nhw 's later mean age at diagnosis of 68.86 years  11.239 , an earlier onset was observed among api ( 68.05  12.315 years ) , hispanics ( 67.40  12.395 years ) , and blacks ( 64.65  11.467 years ) ( p < 0.05 ) . greater than 50% of cases among blacks were seen in the 5th ( 25.4% ) and 6th ( 31.3% ) decades , respectively , compared to the majority of the cases that presented later in the 6th and 7th decades among other ethnicities ( p < 0.05 ) . in our study , blacks ( 29.2% ) had the highest status , followed by hispanics ( 15.4% ) , and nhw ( 10.5% ) , with lowest observations noted among api ( 9.5% ) . blacks ( 32.9% ) and nhw ( 33.0% ) had higher  others  status , with relative lower proportions observed amongst hispanics ( 29.3% ) and api ( 22.5% ) ( p < 0.05 ) . finally , married individuals were significantly more common among aip ( 64.9% ) and less common among blacks ( 33.6% ) compared to nhw ( 33.0% ) . significant majority of the api ( 58.2% ) were born outside the united states ( us ) . a greater proportion of hispanics ( 34.9% ) , compared to nhw ( 4.1% ) , and blacks ( 1.5% ) are born outside ( p < 0.05 ) . no tumor was found  in 0.3% of the black population , compared to ( 0.4% ) nhw ( p < 0.05 ) . both nhw ( 31.0% ) and api ( 27.8% ) had the greater proportion of tumor 30  mm , compared to blacks ( 25.1% ) and hispanics ( 26.7 ) , respectively . a similar trend of proportionality was observed in tumors greater than 30  mm but not more than 50  mm , with api ( 23.7% ) and nhw ( 22.6% ) being higher , compared to blacks ( 22.0% ) and hispanics ( 21.0% ) ( p < 0.05 ) . alternatively , blacks had relatively greater proportion of tumors greater than 50  mm , followed by hispanics , nhw , and api , respectively . with regard to stage i nsclc cases , radiation was less frequently utilized in both api ( 11.0% ) and hispanics ( 12.2% ) compared to nhw ( 16.3% ) whereas greater proportions of blacks ( 18.9% ) were treated with radiation ( p < 0.01 ) . this trend was also observed in stage ii cases , with relatively more nhw ( 33.9% ) and blacks ( 36.9% ) than api ( 26.5% ) and hispanics ( 28.6% ) receiving radiation as part of their treatment ( p < 0.01 ) . higher rates of blacks ( 57.3% ) had radiation as part of the treatment in stage iii followed by nhw ( 55.3% ) , api ( 50.5% ) , and hispanics ( 48.2% ) ( p < 0.01 ) . similarly , blacks ( 44.9% ) had the highest proportions of radiation utilization compared to nhw ( 44.1% ) , api ( 41.0% ) , and hispanics ( 39.1% ) in the stage iv cohort ( p < 0.01 ) . for ajcc stage i cases , a greater proportion of api ( 80.4% ) were treated with cancer directed surgery compared to hispanics ( 75.4% ) , nhw ( 75.6% ) , and blacks ( 65.7% ) ( p < 0.01 ) . blacks ( 35.1% ) had the lowest rate of surgical treatment in stage ii while nhw ( 47.3% ) had the highest rate followed by api ( 44.7% ) and hispanics ( 44.7% ) ( p < 0.01 ) . compared to nhw ( 17.0% ) , lower rates of surgical treatment in blacks ( 12.0% ) were observed while api ( 20.4% ) and hispanics ( 19.4% ) had greater proportions that underwent surgery ( p < 0.01 ) . nhw ( 4.5% ) had the highest proportion of cancer directed surgery compared to hispanics ( 3.8% ) , api ( 3.6% ) , and blacks ( 3.5% ) in stage iv nsclc ( p < 0.01 ) . the most common reason for no surgery for all ethnicities was because it was  not recommended . this reason was proportionally more common among api and least among blacks ( p < 0.05 ) for all ajcc stages except stage i ( p < 0.05 ) . in contrast , api had the highest proportion of refusal for surgical treatment in early stage nsclc patients ( p < 0.05 ) . multivariate cox proportional models were utilized to analyze the variables contributing to the dss among different ajcc stage . demographic variables that had improved survival at each ajcc stage were ; female gender , and being married , ( p < 0.05 ) . immigrants born outside the us had significant improved survival outcome in comparison to us born patients . patients with stage ii diagnosed at age 7079 ( hazard ratio [ hr ] : 4.077 , p < 0.05 ) and > 80 ( hr : 5.14 , p < 0.05 ) had poor outcomes ; patients > 80 years had worsened survival among stage iv ( hr : 1.626 , p < 0.05 ) . api had a significantly improved survival in stage i ( hr : 0.775 , p < 0.05 ) , stage ii ( hr : 0.791 , p < 0.05 ) , and stage iv ( hr : 0.858 , p < 0.05 ) . this improvement was not observed in stage iii ( hr : 0.966 , p > 0.1 ) . unlike api , both hispanics and blacks did not have impact on the survival favorably compared to nhw ( table 3 ) . higher grade was uniformly associated with poor prognosis across all the stages ( p < 0.05 ) . however both ais and non - ais diagnoses ( with the exception of stage ii , hr : 0.966 , p > 0.05 ) were both associated with improved survival compared to the referent squamous and transitional diagnosis , with ais being the more favorable diagnosis ( table 2 ) . iii hr : 0.60 , and stage iv : 0.917 , p < 0.01 ) . surgical treatment favorably impacted stage i ( hr : 0.231 ) , and stage ii ( hr : 0.282 ) survival respectively , ( p < 0.01 ) . this study utilized the seer database to examine racial / ethnic disparities in nsclc clinicopathologic features and stage - based survival outcomes . api were more likely to be diagnosed with ais histology but yet presented with late stage disease . our analysis showed that cancer directed surgery and radiation therapy were significantly less likely to be offered to api compared to nhw . despite this , compared to nhw , api had increased disease - specific survival for early stage ( i and ii ) and stage iv nsclc . this analysis determined that survival disparities are also seen in api based on the recent ajcc 7th edition staging system . previous retrospective analyses have shown api to have decreased mortality compared to nhw for stage i disease , with an overall survival advantage regardless of smoking status which is consistent with our results [ 79 ] . our analysis also found increased survival in api with stage ii disease compared to nhw . stage iv disease was seen more frequently in api than in nhw with lower rates of cancer directed surgery and radiation therapy . despite this , there was a survival advantage for api compared to nhw in stage iv nsclc which is consistent with prior studies . improved outcomes in api may be attributed to favorable demographic and clinicopathologic features demonstrated in our analysis including being married , birth outside of the us , ais histology , and earlier age at diagnosis . regarding treatment modalities in stage iv , despite improved survival , the api cohort was less likely to receive cancer directed surgery compared to nhw . pertinently , there was greater proportion of surgery which was not part of the treatment plan . according to chang et al . , api as a group had better overall survival after nsclc diagnosis compared to nhw , and single marital status was associated with decreased survival in the api population , which is consistent with our results . nsclc is a heterogeneous disease that is influenced by genetic , lifestyle , and socioeconomic elements . these elements are likely major factors in the disparate presentations and outcomes among different racial / ethnic groups . smoking status is an important prognostic indicator , with an improvement in overall and disease - specific survival in never smokers compared to patients with a smoking history [ 9 , 11 ] . response to therapy including surgery , chemotherapy , and radiation is also improved in never smokers even in advanced disease . unlike nhw and black patients diagnosed with nsclc , a relatively high percentage of never smokers are seen in the api us population . however , besides smoking status , additional factors may account for improved outcomes because asian ethnicity independently is a favorable prognostic indicator for overall survival in both smokers and never smokers . in addition to a higher prevalence of smoking in lower ses groups , they are unlikely to receive adequate health care . in prior observational studies , blacks were less likely to receive surgery , chemotherapy , or radiation for stage iii disease and were less likely to receive chemotherapy for stage iv disease in comparison to nhw [ 1618 ] . in our study , cancer directed surgery was less likely to be offered to blacks compared to nhw . however , our study is unique in that it demonstrates that radiation is more significantly likely to be administered to blacks diagnosed with nsclc . poor access to quality health care is a major factor in racial / ethnic disparities , which have shown that when equivalent health care access is provided , survival outcomes become comparable [ 3 , 13 , 19 , 20 ] . further research is necessary to determine whether lung cancer treatment is suboptimal in api residing in the us . overexpression of the epidermal growth factor receptor ( egfr ) leading to aberrant tyrosine kinase mediated signaling is implicated in approximately 70% of nsclc cases and is associated with a poor prognosis ; egfr tyrosine kinase inhibitors ( tki ) were developed as a potential therapeutic option to improve outcomes . a greater understanding of the activity of tki has led to the discovery that the efficacy of these inhibitors is dependent on the presence of egfr activating mutations instead of the degree of egfr overexpression . egfr activating mutations are seen more commonly in females , ais histology , never or light smokers , and east asians [ 22 , 23 ] . the prevalence of egfr activating mutations in other racial / ethnic groups such as blacks and nhw appears to be highly variable [ 2426 ] . improved survival in api potentially could be due to the presence of these mutations ; however , randomized controlled trials have not shown an overall survival benefit with tki therapy in the adjuvant , stage iii maintenance , first - line metastatic , and second - line treatment settings [ 2731 ] . this could have led to incorrect classification of race / ethnicity and tumor classification . in our analysis however , we found the number of missing cases to be proportional among different racial / ethnic groups . in addition , we were not able to account for both genetic and lifestyle factors linked to nsclc including testing for egfr , kras , and alk mutations , familial history , smoking history , and occupational exposure to carcinogens . this is the first seer analysis to utilize the recent ajcc 7th edition to determine survival outcomes in api compared to nhw . interestingly , in all stages , except for stage iii , there was a significant survival benefit . this may be due to an insufficient sample size but also may be due to disparities in tumor biology and lifestyle factors specific for this stage . further research is necessary to gain a better understanding of the nsclc outcomes in the api population residing in the us .
background . 
 the objective of our study was to ascertain racial / ethnic disparities in asian / pacific islanders ( api ) for non - small - cell lung cancer ( nsclc ) clinicopathologic features and survival outcomes based on various tumor characteristics and treatment modalities . 
 method . 
 seer database identified invasive nsclc cases from 2004 to 2010 . 
 variables included american joint committee on cancer ( ajcc ) stage 7 , tumor grade , tumor size , histology , age , marital status , radiation , surgery , and reason for no surgery . 
 the kruskall - wallis test and the z test were used to examine differences between races / ethnicities and the referent , non - hispanic white ( nhw ) . 
 multivariate cox proportional analyses were used to establish the weight of the prognostic significance contributing to disease - specific survival ( dss ) in each ajcc stage . result . 
 improved dss was seen in api across stage i ( hr : 0.78 ) , stage ii ( hr : 0.79 ) , and stage iv ( hr : 0.86 ) , respectively , compared to the referent nhw ( p < 0.01 ) . 
 prognosis was improved by being married , being female gender , ais histology , and birth outside the us ( p < 0.01 ) . conclusion . 
 we have demonstrated improved survival among api in early stage and stage iv nsclc . 
 further research is necessary to clarify the role of lifestyle and tumor biology for these differences .