first - line procedural investigations for non - specific epigastric pain include endoscopy and endosonography , combined with biopsy of suspicious areas in the upper gastrointestinal tract . despite high sensitivity and specifity , obtaining a definite histopathologic differentiation is sometimes unsuccessful , particularly if biopsy is not representative , e.g. because of tumor bleeding into the affected tissue . in such a case , the single remaining diagnostic option is a curative laparoscopic endoscopically - assisted wedge - resection of the stomach . we present an interdisciplinary case report in which a tumor of the stomach , suspicious for gist , was removed surgically and was found to be a benign glomus tumor by definitive histology . a 44-year old patient presented with relapsing epigastric pain of variable intensity and tarry stool , beginning three days earlier . there were no clinical or laboratory findings to suggest an acute posthemorrhagic anemia ( hemoglobin 14.7 g / dl , hematocrit 43.2% , pt 118% , aptt 27 s ) . upper endoscopy and endosonography were performed , revealing a spherical , submucosal , solid tumor approximately 50 mm in diameter located in the pyloric antrum ( fig . overlying ulceration was considered the likely source of bleeding , and fine needle biopsy of the lesion ( 19 g ) was performed , followed by preventive clip - application . an endosonographic picture with a poorly reflective , non - homogeneous pattern and echo - free areas was compatible with a 35  30 mm gist ( fig . investigations thus far were inadequate to exclude a malignant process , and surgery ( endoscopically - assisted laparoscopic wedge - resection of the stomach ) was indicated . histological section of the surgical specimen revealed a rare benign glomus tumor ( positive reaction on markers specific for glomus tumor ( vimentin / actin ) , fig . glomus tumor is a ( quite ) rare neoplasm and despite local invasion of vessels is mostly benign . it is often found in the skin ( particularly in the dermis / subcutaneous tissues of the limbs ) , but can also be found in the gastrointestinal tract ( usually intramurally in the mucosa / submucosa and serosa ) as well as other solid organs . the present assumption that the first glomus tumor of the stomach was identified in 1948 and described with another two cases in 1951 smol'iannikov wrote that the first glomus tumor of the stomach was clearly described in a 64-year old man in 1928 by talijeva . furthermore , the first malignant glomus tumor of the stomach was diagnosed in 1939 by kirschbaum et al . in a 40-year old man . there are case reports of malignant glomus tumors of the stomach in girls aged 1214 years , published by yannopoulos et al . . in addition , there have been a number of reports pertaining to glomus tumors of solid abdominal / retroperitoneal organs and of the colon [ 6 , 7 , 8 ] . there is no gender bias in the incidence of glomus tumors but their peak incidence occurs between the fourth and sixth decade of life . immunohistochemically , most glomus tumors show a positive expression of vimentin / actin without expressing chromogranin a , neuronspecific enolase ( nse ) , carcinoembryonic antigen ( cea ) or epithelial membrane antigen ( ema ) . the rarity of glomus tumor , its variable organ involvement , its non - specific symptoms at presentation and the often equivocal results of standard first line investigations all contribute to diagnostic difficulty . endoscopic and endosonographic images in glomus tumors of the stomach show a solid , submucosal tumor with or without ulceration and do not differentiate it from other important diagnoses , e.g. gist , neuro - endocrine neoplasia ( carcinoid ) , angiomyoma or lymphoma . hence , presurgical diagnostic confirmation is often impossible . only immunohistochemical analysis of representative biopsies ( gist : positive reaction with cd-117 antibodies and missing expression of glomus tumor typical actin / vimentin ) can confirm the diagnosis , and hence aid the clinician in determining appropriate therapy and prognosis [ 9 , 10 , 11 ] . compounding pre - surgical diagnostic difficulties , there have also been reports of malignant transformation of glomus tumor . therefore , surgery or en bloc endoscopic enucleation is in most cases the remaining diagnostic and therapeutic option [ 12 , 13 ] . a definite immunohistochemical confirmation of the diagnosis is essential , because the prognosis of a potentially malignant lesion is otherwise unpredictable . in the case presented , a patient with recurring epigastric pain and melaena , there was an endoscopic and endosonographic finding of a submucosal tumor of the gastric antrum . given the non - diagnostic biopsy result and the ongoing risk of gastrointestinal bleeding , endoscopically assisted laparoscopic wedge - resection of the stomach was performed as a combined diagnostic and therapeutic procedure . histological and immunohistochemical analysis of the resected tissue showed an entirely removed ( ro ) glomus tumor . unlike gist , if complete removal of a benign glomus tumor ( ro ) is verified histologically , there is no indication for further specific therapy [ 14 , 15 ] . sonographic ( for solid organs ) and endoscopic follow - up for early detection of recurrence or metastasis constitutes the most reasonable postoperative follow - up .
glomus tumor is an infrequent and in most cases benign mesenchymal neoplasia which affects subcutaneous / submucosal tissue and occurs in the gastrointestinal tract , solid organs ( e.g. liver , kidney ) and the extremities . 
 visceral glomus tumor of the stomach generally presents with non - specific epigastric pain , loss of appetite and gi bleeding ( melaena ) , often without haemodynamic instability . 
 macroscopic appearances on upper gi endoscopy are non - diagnostic . 
 endosonographic appearances are generally heterogenous and poorly - reflective , hence fail to differentiate glomus tumor from other potential diagnoses . 
 histological confirmation of the diagnosis is only possible when a fine needle biopsy is inclusive of abnormal tissue . 
 these difficulties in diagnosis mean that in many cases , only immunohistochemical analysis of surgically resected tissue can distinguish glomus tumor from several possible differentials . 
 therefore , endoscopically - assisted laparoscopic curative wedge - resection of a lesion suspicious for glomus tumor of the upper gastrointestinal tract must be considered first - line in terms of a combined investigative and curative approach .