the management of parkinson 's disease ( pd ) is often enhanced by complementary rehabilitation strategies , such as exercise . for example , studies of resistance [ 13 ] and endurance [ 47 ] exercise training have improved balance , gait , postural stability , and physical function and reduced falling in people with pd . tai chi , a traditional chinese martial art that involves meditation and slow , graceful movements , is often recommended to reduce stress , improve mood , flexibility , physical function , and balance [ 810 ] . studies of tai chi in people with chronic disease including parkinson 's disease and old people have supported the potential for benefit , with gains in the quality of life , postural stability , gait , physical function , immune function , cardiometabolic disease risk factors , and other health - related parameters [ 4 , 1119 ] . however , research on the effectiveness of tai chi is contradictory due to inconsistencies in the implementation of the tai chi movements , limited samples , and the lack of randomized control trials . the purpose of this study is to investigate the effects of a randomized control trial of therapeutic tai chi training on improving the motor function and physical function of parkinson 's disease patients . all participants gave informed consent in accordance with the procedures of the parkinson 's disease center and the sports medicine center of the asan medical center . the participants of this study were 24 clinically stable patients with diagnosed idiopathic parkinson 's disease recruited from the parkinson 's disease center in asan medical center in seoul , republic korea . eligible participants met the following inclusion criteria : ( 1 ) hoehn - yahr stage 1 or 2 and ( 2 ) stable drug regimen . volunteers were excluded from the study if they had ( 1 ) severe cognitive impairment , ( 2 ) concomitant severe neurologic , cardiopulmonary , or orthopedic disorders , ( 3 ) specific contraindications to exercise , or ( 4 ) they had recently participated in any physiotherapy or rehabilitation program . the volunteers were screened for inclusion and exclusion criteria based upon the medical history and physical examination . participants were randomized to either a twelve - week intervention of therapeutic tai chi ( ttc ) or a non - exercise control group ( see figure 1 ) . the ttc group visited the clinic 2 times a week and performed home - based activity 1 time per week for 12 weeks . each ttc session started with a 10-minute stretching exercise warm - up , followed by 30 minutes of tai chi exercises , and ending with 10 minutes of meditation and 10 minutes of stretching exercise cool - down . the exercise was performed within the intensity ranges of 11 to 15 ( light to somewhat hard ) on the borg ratings of perceived exertion ( rpe ) scale . study outcome measures were obtained at baseline ( prerandomization ; one week prior to the start of the program ) and within one week following the end of the 12-week intervention . the outcome measures included several test of physical function ( lateral stance , agility , tandem gait , timed up and go , and six - minute walk ) and the unified parkinson 's disease rating scale ( updrs ) sections 13 . all the tests were performed in the same order , at the same time of day , and when the participant felt best . the participant stands with hands on hips with eyes closed ; when ready , the participant stands on the foot of choice for as long as possible , with the knee of the other leg flexed to 90 degrees . when a light comes on , they jump up as fast as possible in response to a single light stimulus . the tandem gait test   was used to assess balance , appendicular coordination , and gait , which involves multiple sensory and motor systems . the participant walks in a straight line while touching the heel of one foot to the toe of the other with each step . for the timed up and go test , the participant was seated in an arm chair ( 45  cm high ) with their back against the chair . on a signal , they stand up , walk 3 meters as quickly and safely as possible , turn around , walk back to the chair , and sit down with their back against the chair . the six - minute walk test   was applied as a test of cardiorespiratory endurance for daily physical activities . this test measures the distance that can be walked at a self - paced velocity on a flat hard surface over a period of six minutes . an analysis of variance ( anova ) for repeated measures with one between factor ( treatment group ; ttc versus control ) and one within factor ( time ; pre- and postintervention ) was used to evaluate the effects of the intervention . a total of 11 participants were randomized to the ttc and 11 participants to the control condition . two subjects in the control group did not complete the study for personal reasons unrelated to the study . as shown in table 3 , significant changes were observed in the mentation , behavior , and mood subscale and the motor subscale of the updrs , with no significant main effects on the activities of daily living scale ( adl ) , balance , or reaction time . however , there were significant interactions between time and intervention group on the updrs activities of daily living subscale ( figure 2 ) . however , as shown in figures 3 and 4 , there were significant ( p < 0.05 ) interaction effects for balance ( one - leg standing test ) and reaction time ( light stimulus ) . in this study , we investigated the motor and nonmotor effects of therapeutic tai chi exercise training on participants with pd . the findings of our study showed modest effectiveness of tai chi training on people with parkinson 's disease , with significant interaction effects for balance , reaction time , and adls . these findings support that tai chi is effective in improving some aspects of motor function , most notably reaction time and balance . in addition , pd participants reported an improvement in their ability to engage in their activities of daily living . exercise therapy has a major role in the rehabilitation of the patients with parkinson 's disease [ 26 , 27 ] . regular physical activity may increase the functional ability and enhance the capacity for independent living by decreasing the need for assistance with the activities of daily life . in addition , exercise may achieve the goal of neuroprotection , slow disease progression , and postpone disabilities [ 28 , 29 ] . several cohort studies have described the functional achievements of moderately affected parkinson 's disease participants who have undergone intensive standardized exercise training [ 3033 ] . however , burini et al .   reported in a study with a crossover design that a 7-week tai - chi and aerobic exercise training did not affect the severity of neurological signs and symptoms as assessed by the updrs or have any significant impact of training on the attendant disability . .   showed that physical therapy is mainly focused on mobility rather than various neurologic symptoms such as rigidity and tremor . reported that some aspects of the mobility and balance functions were positively affected by tai chi exercise . however , assessing the mobility and balance function by only one item , such as the walking function , is not very representative of the spectrum of the motor signs and symptoms . furthermore , there is little attention toward non - motor symptoms such as fatigue mood and health quality of life , all of which may be altered by exercise [ 27 , 3740 ] . in a recently published clinical trial , li et al .   found beneficial effects of tai chi exercise on balance , physical function , and falls , suggesting that tai chi is an appropriate physical activity for patients with parkinson 's disease and it might be useful as a therapeutic exercise . the ability to balance is related to the control of the center of gravity within the base of support . koller and huber   found that the balance impairment in older adults with a longer duration of pd does not usually respond to levodopa ; 38% of the persons with pd experience fall , 13% fall more than once per week , and some studies have reported that pd patients fall repeatedly throughout the day . persons with pd are 5 times more likely to suffer falls - related injuries such as hip fractures than healthy older adults . reaction time for agility was measured in the present study and improved with ttc training . ttc training has benefits for postural stability in elderly people , including patients with pd , likely by acting on a number of sensorimotor systems that contribute to postural control [ 12 , 43 , 44 ] . this improvement combined with the observed improved agility performance confirms the separate observations of previous studies showing that ttc training results in better balance capacity , proprioception function , and muscle strength [ 11 , 4547 ] . while our study and other studies have shown enhanced balance and agility resulting from tai chi , further work is needed to confirm that these improvements in fall risk factors actually result in fewer falls , as there are somewhat contradictory findings in the literature [ 19 , 45 , 48 ] . physical function refers to the assessment of the capability to complete a specific task rather than assessing the physiologic - derived attributes , and it is believed to reflect the ability to carry out activities of daily living . in the present study , we assessed the physical function with the timed up and go , tandem gait , and six - minute walk tests . the timed up and go test showed no significant change after training , which is in contrast to the findings of li et al . . these differences may be due to differences in the programs of tai chi , the wider range of disease severity in the study by li et al . , or the smaller numbers of participants in our study . the timed up and go test largely depends on the muscular power and strength of the quadriceps and the hip extensor muscles to arise from a chair [ 49 , 50 ] . it may be that our version of tai chi does not substantially improve lower extremity power . the results of the tandem gait test and the six - minute walk test were also not changed after 12 weeks of ttc training . poor performance on the tandem gait and six - minute walk could result from several potential factors , including poor cardiorespiratory fitness and gait or balance abnormalities [ 23 , 51 ] . many of the pd participants likely had poor cardiorespiratory fitness and inadequate levels of physical activity , as shown by garber and friedman . consistent with this finding , all of the participants in this study had below normal results on the six - minute walk test , suggesting that poor cardiorespiratory fitness , gait , and/or balance may have been an important determinant of performance . other studies of tai chi have not shown an improvement in cardiorespiratory fitness , and our results are consistent with these previous findings . this study investigated motor function and the severity of motor and non - motor symptoms and signs . these motor and nonmotor symptoms and signs were not improved after treatment , although self - reported engagement in activities of daily living was enhanced by tai chi exercise . ttc training involves splitting up complex movements into simple motor tasks and incorporating simultaneous movements , which is also beneficial for parkinson disease patients . thus , this study lends additional evidence for tai chi as a complementary treatment for people with parkinson 's disease  one that will allow them to engage more fully in their activities of daily living . further studies are needed that will consider the effects of various components of a tai chi program and also to help to identify the intensity , duration , and frequency of tai chi exercise to attain optimal benefits . further , the influence of various medication and dietary factors may moderate the effects of exercise , and this has also not been studied .
objective . 
 the purpose of the study was to investigate the effects of a 12-week program of therapeutic tai chi on the motor function and physical function of idiopathic parkinson 's disease patients ( pds ) . 
 methods . the participants were 22 clinically stable pds in hoehn - yahr stages 1 - 2 randomly assigned to a therapeutic tai chi group ( ttc , n = 11 ) or a control group ( con , n = 9 ) . 
 two subjects in control group did not complete the study for personal reasons . 
 ttc was performed three days a week ( 60  min / session ) . 
 motor symptoms by the updrs were assessed , and tests of physical function were administered before and after the 12-week trial . results . 
 the ttc group , as compared to the con group , showed changes in the mentation , behavior , mood , and motor scales of the updrs ( p < 0.05 , p < 0.01 , resp . ) , with no significant main effects on the activities of daily living scale ( adl ) . 
 however , there was a significant interaction between the time and intervention group on adl ( p < 0.05 ) . 
 there were no significant main effects for any of the physical function variables . 
 there were significant interaction effects in balance and agility ( p < 0.05 , resp . ) . conclusions . 
 this study showed that ttc training had modest positive effects on the functional status of parkinson 's disease patients .