the indication for tricuspid valve ( tv ) surgery is mostly considered at the time of mitral or aortic valve surgery and most often because of tricuspid regurgitation ( tr ) . concomitant tv repair in this scenario does not significantly increase cross - clamping time and may reduce the morbidity associated with reoperation for isolated tr , leading to an increase in operative correction procedures over the past decade . hence most follow - up studies are concerned with comparing the difference between tricuspid annuloplasty / repair ( tap ) and tricuspid valve replacement ( tvr ) . however , few studies have investigated the outcome in patients with the need of tricuspid surgery because of isolated tv pathology . the etiologies here for consist mostly for annular dilation , infective endocarditis ( ie ) , congenital ( structural ) pathology of the leaflets , post - interventional destruction ( e.g. , post - biopsy or pacemaker implantation ) , and rarely rheumatic disorder . severe tr is associated with poor prognosis and surgical treatment is known to provide a superior outcome than conservative medical treatment . we present our follow - up data to evaluate long - term outcomes in patients undergoing isolated tap or tvr . data analysis was handled anonymously and without additional patient contact or examinations , hence our institutional review board waived the need of informed consent . between february 1995 and june 2011 , 109 consecutive patients underwent isolated tv procedures at university hospital of heidelberg : 41 ( 37.6% ) received tricuspid valve annuloplasty / repair ( tap ) and 68 ( 62.3% ) underwent tricuspid valve replacement ( tvr ) . the majority of patients suffered from tricuspid regurgitation due to structural pathology , annular dilation , or infective endocarditis . detailed breakdown of pathologies revealed 32 patients suffered from isolated tricuspid endocarditis while 16 patients had prior pacemaker implantation causing valve defects in form of microbial vegetation , structural damage , or stenosis , 37 patients had tricuspid insufficiency ( ti ) because of annular dilation caused by right ventricular dilation or dcmp , while four patients had prior aortic or mitral valve replacements and developed severe ti in the further clinical course , whereas six patients suffered ti after cardiac transplantation . six patients had congenital anomalies such as ebstein s malformation , rvoto , or asd - ii . furthermore , four patients suffered from mechanical tk - prosthesis thrombosis , four patients had primary tricuspid stenosis and one patient developed severe insufficiency after blunt trauma causing contusio cordis . comprehensive data such as patient demographics , cardiovascular risk factors , cardiac function assessed by two - dimensional echocardiograms , intraoperative characteristics as well as the postoperative outcomes including long - term survival were compared ( tables 13 ) . in most cases the procedures were performed through median sternotomy using cardio - pulmonary bypass ( cpb ) with cardioplegic arrest and standard cannulation of ascending aorta and venae cava superior and inferior ( bicaval cannulation ) . however , some cases were performed through a transversal ( n=1 , 2% ) , parasternal ( n=1 , 2% ) , or antero - lateral ( n=3 , 7% ) access . an alternative cannulation strategy through the femoral vessels was used in three patients ( 7% ) . there were several techniques applied depending on the morphological abnormalities of the valve including standard ring annuloplasties ( n=11 ) , ring reconstructions or tightening using the devega technique ( n=6 ) , valvuloplasty with pericardial patching or bicuscpidalization ( n=20 ) , commissurotomy ( n=2 ) , papillary muscle or chordae plasty or combination of them . the procedures were performed through median sternotomy except for two cases ( 3% ) where the anterolateral access was used . all procedures were done under cpb with cardioplegic arrest and ascending aorta cannulation as well as bicaval cannulation . an alternative cannulation strategy through the femoral vessels was used in seven patients ( 10% ) . the choice of prosthesis was primarily based on patients age , hence patients up to the sixth decade received mechanical and patients in their sevenths decade received biological prosthesis . exceptions were decided in respect to patients comorbidities , such as contraindications for continued anticoagulation and prosthesis were chosen in consent with the patient . intravenous heparin infusion was started on the first postoperative day . a target activated partial thromboplastin time of 5070 seconds after removal of chest drains , warfarin medication was initiated to keep the international normalized ratio ( inr ) between 2.53.5 . patients receiving biological prosthesis or annuloplasty / repair discontinued warfarin three months after surgery , if no other reason for anticoagulation existed . patients with mechanical prosthesis needed to continue lifelong anticoagulation . all data were processed with the statistical package for social sciences ( spss inc . , continuous data were shown as mean  standard deviation and analyzed with the student t - test . data analysis was handled anonymously and without additional patient contact or examinations , hence our institutional review board waived the need of informed consent . between february 1995 and june 2011 , 109 consecutive patients underwent isolated tv procedures at university hospital of heidelberg : 41 ( 37.6% ) received tricuspid valve annuloplasty / repair ( tap ) and 68 ( 62.3% ) underwent tricuspid valve replacement ( tvr ) . the majority of patients suffered from tricuspid regurgitation due to structural pathology , annular dilation , or infective endocarditis . detailed breakdown of pathologies revealed 32 patients suffered from isolated tricuspid endocarditis while 16 patients had prior pacemaker implantation causing valve defects in form of microbial vegetation , structural damage , or stenosis , 37 patients had tricuspid insufficiency ( ti ) because of annular dilation caused by right ventricular dilation or dcmp , while four patients had prior aortic or mitral valve replacements and developed severe ti in the further clinical course , whereas six patients suffered ti after cardiac transplantation . six patients had congenital anomalies such as ebstein s malformation , rvoto , or asd - ii . furthermore , four patients suffered from mechanical tk - prosthesis thrombosis , four patients had primary tricuspid stenosis and one patient developed severe insufficiency after blunt trauma causing contusio cordis . comprehensive data such as patient demographics , cardiovascular risk factors , cardiac function assessed by two - dimensional echocardiograms , intraoperative characteristics as well as the postoperative outcomes including long - term survival were compared ( tables 13 ) . in most cases the procedures were performed through median sternotomy using cardio - pulmonary bypass ( cpb ) with cardioplegic arrest and standard cannulation of ascending aorta and venae cava superior and inferior ( bicaval cannulation ) . however , some cases were performed through a transversal ( n=1 , 2% ) , parasternal ( n=1 , 2% ) , or antero - lateral ( n=3 , 7% ) access . an alternative cannulation strategy through the femoral vessels was used in three patients ( 7% ) . there were several techniques applied depending on the morphological abnormalities of the valve including standard ring annuloplasties ( n=11 ) , ring reconstructions or tightening using the devega technique ( n=6 ) , valvuloplasty with pericardial patching or bicuscpidalization ( n=20 ) , commissurotomy ( n=2 ) , papillary muscle or chordae plasty or combination of them . in most cases the procedures were performed through median sternotomy except for two cases ( 3% ) where the anterolateral access was used . all procedures were done under cpb with cardioplegic arrest and ascending aorta cannulation as well as bicaval cannulation . an alternative cannulation strategy through the femoral vessels was used in seven patients ( 10% ) . the choice of prosthesis was primarily based on patients age , hence patients up to the sixth decade received mechanical and patients in their sevenths decade received biological prosthesis . exceptions were decided in respect to patients comorbidities , such as contraindications for continued anticoagulation and prosthesis were chosen in consent with the patient . intravenous heparin infusion was started on the first postoperative day . a target activated partial thromboplastin time of 5070 seconds after removal of chest drains , warfarin medication was initiated to keep the international normalized ratio ( inr ) between 2.53.5 . patients receiving biological prosthesis or annuloplasty / repair discontinued warfarin three months after surgery , if no other reason for anticoagulation existed . patients with mechanical prosthesis needed to continue lifelong anticoagulation . all data were processed with the statistical package for social sciences ( spss inc . , continuous data were shown as mean  standard deviation and analyzed with the student t - test . there were no statistically significant differences between the two groups regarding age ( 50.719.4 years in the tap group vs. 55.715.9 years in the tvr group , p=0.163 ) , gender distribution ( 43.9% vs. 54.4% female patients in the tap and tvr groups , respectively , p=0.305 ) , and body mass index ( bmi ) ( 24.55.2 in the tap group vs. 24.96.9 in the tvr group , p=0.713 ) . moreover , there were no significant differences regarding preoperative angina or dyspnea status , liver , renal and pulmonary function , infections , hemodynamic status , and cardiovascular risk factors ( table 1 ) . furthermore , the differences between the two groups in terms of previous coronary ( p=0.481 ) , aortic valve ( p=1.000 ) , mitral valve ( p=0.530 ) , or pulmonary valve surgery ( p=1.000 ) was not statistically significant , whereas patients in the tvr group had a significantly higher rate of previous tricuspid valve repair ( p=0.013 ) . preoperative cardiac function assessed by transesophageal echocardiography was also similar and the severity of the disease reflected by pulmonary hypertension and right ventricular function did not differ significantly in both groups ( table 2 ) . additionally , there was no significant difference in the intraoperative characteristics in terms of cross clamping time or urgency of the procedure ( table 3 ) . postoperatively , patients from both groups had similar left ventricular and right ventricular function assessed by two - dimensional echocardiography . there were no statistically significant differences in terms of postoperative arrhythmias , the need for intra - aortic balloon pump or ventricular assist device implantations . both groups were comparable in terms of inotropic support requirement , postoperatively , except for noradrenaline support which was needed more frequently in the replacement group ( 50.0% in the tvr group vs. 24.4% in the tap group , p=0.014 ) . the distribution of postoperative complications such as renal failure requiring conservative treatment , dialysis / hemofiltration , pleural effusions requiring negative balance , or drainage was similar in both groups ( table 4 ) . early survival at 30 days after surgery was 97.6% in the tap group and 91.1% in the tvr group . after 6 months , 89.1% in the tap group and 87.8% in the tvr group were alive . in terms of long - term survival , there was no further mortality observed after one year post - surgery in both groups ( log rank p=0.919 , breslow p=0.834 , tarone - ware p=0.880 ) in the kaplan - meier survival analysis . the 1- , 5- , and 8-year survival rates were 85.8% for tap and 87.8% for tvr group ( figure 1 ) . significant tricuspid disease requiring surgical correction is a challenging pathology , demanding critical decision - making regarding reconstruction versus replacement and timing of the procedure . the reasons here for are the reported high mortality and the fact that tr is relatively well tolerated , even if severe . hence patients present with complex morbidity such as manifest congestive heart failure , severe cardiac dilation , pulmonary hypertension or endocarditis . the presence of these serious preoperative conditions present highly confounding factors altering postoperative outcomes significantly and probably accounting for previously reported poor outcomes . currently the indication for surgical correction vs. replacement remains at the surgeon s discretion , although recently there is a growing tendency towards reconstructive strategies . theoretical benefits are the avoidance of inserting a rigid prosthesis into the thin - walled , low - pressure right ventricle , which can result further deterioration of right - ventricular dysfunction [ 911 ] . however , early and long - term outcomes after tap show high rates of recurrent tr despite the use of annuloplasty rings . in a large series reported by the toronto group and the cleveland clinic group the recurrence of moderate to this can account for diminished survival because deteriorating right ventricular function and redo tricuspid valve surgery in that case is associated with higher morbidity and mortality . however , most studies include a variety of patients in their analysis , especially those in need of multiple cardiac interventions . in this study however , only isolated tricuspid valve pathologies were analyzed , thus our patient cohort was more uniform concerning preoperative characteristics and direct comparison between the test groups is feasible without the need for statistical alterations such as pair - matched analysis or propensity score matching . age , gender , bmi , and the severity of the disease were comparable in both groups . known preoperative risk factors like right ventricular function and pulmonary hypertension were also similar , as well as known operative confounding factors like cross clamping time or the urgency of the procedure . the overall results of this study show that the outcome after tricuspid surgery is acceptable with 30-day survival of 97.6% in the tap group and 91.1% in the tvr group and long - term survival of 85.8% in the tap and 87.8% in the tvr group . these rates are in accordance with , if not better , than in previous published studies . however , our promising results might be overestimated by a relatively small number of patients and therefore lower statistical power . nonetheless the outcomes are somewhat disappointing when compared with survival after left sided valve replacement operations , even after exclusion of patients with complex cardiac pathologies needing multiple surgical corrections . with survival rates at 1- , 5- , and 10 years of 80% , 72% , and 66% for repair and 85% , 79% , and 49% respectively for the replacement group , without statistical significance . the incidence of major adverse cardiac events was also similar in both groups , as were clinical surrogate parameters , except for the use of noradrenaline : which was significantly more needed in the tricuspid replacement group . this may be due to the fact that this patient group had a longer cpb time and thus suffered more vasoplegia in the early postoperative period . thus the main finding of this study is that there is no clear benefit when comparing tricuspid repair to replacement . hence the growing enthusiasm towards corrective procedures needs to be put into perspective and focus needs to be shifted towards the timing of the procedure to maintain right ventricular function . current guidelines recommend surgical intervention when patients become symptomatic , which might lead to significant progression of the disease and further deterioration of right ventricular function . however , it has been shown that tr reduces exercise capacity and negatively affects long - term outcome , irrespective of pulmonary hypertension or left ventricular function [ 1619 ] . echocardiographic parameters of right ventricular function could be consulted when determining optimal timing of surgical intervention . the decision should lean towards valve replacement in patients with reasonable suspicion of recurrent regurgitation .
backgroundlong - term follow - up data concerning isolated tricuspid valve pathology after replacement or reconstruction is limited . 
 current american heart association guidelines equally recommend repair and replacement when surgical intervention is indicated . 
 our aim was to investigate and compare operative mortality and long - term survival in patients undergoing isolated tricuspid valve repair surgery versus replacement.material/methodsbetween 1995 and 2011 , 109 consecutive patients underwent surgical correction of tricuspid valve pathology at our institution for varying structural pathologies . 
 a total of 41 ( 37.6% ) patients underwent tricuspid annuloplasty / repair ( tap ) with or without ring implantation , while 68 ( 62.3% ) patients received tricuspid valve replacement ( tvr ) of whom 36 ( 53% ) were mechanical and 32 ( 47% ) were biological prostheses.resultsearly survival at 30 days after surgery was 97.6% in the tap group and 91.1% in the tvr group . 
 after 6 months , 89.1% in the tap group and 87.8% in the tvr group were alive . in terms of long - term survival 
 , there was no further mortality observed after one year post surgery in both groups ( log rank p=0.919 , breslow p=0.834 , tarone - ware p=0.880 ) in the kaplan - meier survival analysis . 
 the 1- , 5- , and 8-year survival rates were 85.8% for tap and 87.8% for tvr group.conclusionssurgical repair of the tricuspid valve does not show survival benefit when compared to replacement . 
 hence valve replacement should be considered generously in patients with reasonable suspicion that regurgitation after repair will reoccur .