he presented on multiple occasions with hematemesis , melena and/or hematochezia , associated with hemodynamic instability , and required a cumulative transfusion of more than 100 units packed red blood cells over a period of 8 years . the bleeding was typically preceded by cramping abdominal pain localized in the left upper quadrant . multiple gastrointestinal evaluations were performed , and were unrevealing for a source of the intermittent bleeding . prior to his evaluation at our institution , the patient had undergone 2 esophagoduodenoscopies , a colonoscopy , a tagged nuclear red blood cell ( rbc ) scan and an angiogram , which were within normal limits . an intra - operative enteroscopy was performed in 2000 , which was significant for blood in the 3rd and 4th portions of the duodenum , multiple arteriovenous malformations ( avms ) and a single jejunal diverticulum . the patient presented to our institution in 2001 for further evaluation . over time , repeat endoscopic and radiologic evaluations were performed including 3 upper endoscopies , a colonoscopy and 2 tagged nuclear rbc scans , which were within normal limits . catheter angiograms were performed on three different occasions , including a provocative visceral angiogram with infusion of tissue plasminogen activator , but failed to identify the site of hemorrhage . wedged hepatic vein pressure ( whvp ) was measured by the transjugular approach , and revealed an elevated portosystemic gradient of 18 mm hg , suggestive of portal hypertension . a ct angiogram was performed that showed evidence of a tortuous and prominent splenic artery , otherwise within normal limits . endoscopic retrograde cholangiopancreatography ( ercp ) showed mild dilation of the pancreatic duct , but no other significant findings were appreciated . an intra - operative enteroscopy was then performed , which revealed blood in the distal duodenum , avms and a single diverticulum in the proximal jejunum . this led to a segmental resection of 100 cm of proximal jejunum . despite the surgery however , follow - up push enteroscopy to the mid - jejunum did not reveal angioectasia . nonspecific red spots in the proximal small bowel were seen on two additional video capsule endoscopies , but no definite source for bleeding was identified . argon plasma coagulation of 23 non - bleeding avms in the gastric cardia was performed . double balloon enteroscopy ( dbe ) was performed in 2005 , with normal appearing 205 cm of the distal small bowel and 230 cm of proximal small bowel visualized on retrograde and antegrade dbe , respectively . in july 2005 , the patient developed fever , and multiple blood cultures grew mycobacterium chelonae / abscessus group . antibiotic treatment was initiated with amikacin and clarithromycin , and the porta - cath was explanted . u / l , alt 50 u / l and alkaline phosphatase 229 u / l ) , and splenomegaly ( 22.3 superior - inferior length ) was found on adominal ultrasound . a ct scan of the abdomen revealed multiple large splenic lesions , consistent with subacute or chronic infarcts , a hypodensity at the tail of the pancreas , and inflammatory changes near the splenic hilum at the tail of the pancreas , suggestive of resolving pancreatitis . an endoscopic ultrasound was performed in august 2005 , to evaluate the ct findings , and revealed a 10 mm ill - defined hyperechoic lesion at the tail of the pancreas , suggestive of a benign pancreatic neoplasm . the patient presented with recurrent hematochezia , prompting a repeat provocative visceral angiogram with heparin . , the patient 's fever recurred , prompting a fever reevaluation . a ct scan abdomen demonstrated a 1.5  1.5  1.0 cm saccular aneurysm arising from the distal splenic artery , invaginating the tail of the pancreas ( fig . 1 , fig . the main pancreatic duct was mildly enlarged to 0.6 cm within the head of the pancreas , with gradual taper towards the tail . multiple small infarcts were seen involving the lower third of the spleen . upon retrospective review , the prior angiogram was noted to show a small pseudoaneurysm of the distal third of the splenic artery , which was camouflaged by the tortuousity of the splenic artery ( fig . , images from the prior ercp showed blunting of the main pancreatic duct at the tail of the pancreas , likely due to mass effect or thrombus from the adjacent splenic artery pseudoaneurysm eroding into the pancreatic duct ( fig . the benign neoplasm noted on prior eus , was in fact the pseudoaneurysm containing mural thrombus with focal surrounding pancreatitis . fortunately , needle biopsy of this suspected pancreatic neoplasm was not attempted at the time of eus . the central venous access was explanted , and antibiotic treatment re - initiated with amikacin , clarithromycin , and gatifloxacin . despite 4 weeks of antimicrobial therapy , he experienced progressive unilateral knee , neck and lumbar pains . magnetic resonance imaging identified enhancement and fluid at the l4 - 5 and c4 - 5 interspaces . percutaneous aspiration of the fluid and open knee debridement were performed , with cultures positive for m. chelonae / abscessus . progressive clinical improvement was noted at monthly follow - up appointments , and his knee and spine symptoms resolved . laparotomy was performed , which confirmed the presence of a splenic artery pseudoaneurysm at the tail of the pancreas . pathology was consistent with a 2.5 cm splenic artery pseudoaneurysm , with organized blood clot in the lumen , extending into an epithelial - lined cavity consistent with the pancreatic duct adjacent to the splenic arterial wall , suggestive of previous rupture into the tail of the pancreas ( fig . avvg ( voerhoff vangeesen ) stain showed disruption of the internal elastic lamina of the aneurysm , confirming a fistula from the splenic aneurysm into a dilated section of pancreatic duct . the patient 's post - operative course was complicated by a minor pancreatic duct leak , successfully treated by ercp with a 7 cm , 7 f stent placement . follow - up ercp after 2 months showed resolution of leak and the stent was removed . his hemoglobin , which had been in the range of 89 g / dl , was noted to be improved to 12.7 g / dl , with mcv increased from 75 fl to 89 fl at 6 months follow - up . hemosuccus pancreaticus is defined as bleeding from the pancreatic duct , and was first reported by lower and farrell in 1931 . the term . there are at least 160 cases of hemosuccus pancreatitis reported in the english literature since 1931 . the most common etiology of this relatively rare entity is communication of a splanchnic artery aneurysm with the pancreatic duct , either due to erosion or fistula formation . aneurysms originating from the splenic , hepatic and pancreaticoduodenal arteries have been described in association with hemosuccus pancreaticus . these are usually pseudoaneurysms that occur as a result of pancreatitis or abdominal trauma to the left upper quadrant [ 4 , 6 ] . pseudoaneurysms of the splanchnic arteries presenting as hemosuccus have been reported to involve the splenic artery most commonly ( 6065% ) , followed by the gastroduodenal ( 2025% ) , pancreaticoduodenal ( 1015% ) and hepatic artery ( 510% ) . splanchnic artery pseudoaneurysms have been found to be present in about 10% of patients with chronic pancreatitis . in addition to fistulization into the pancreatic duct , they can present with intraperitoneal hemorrhage and hypotensive shock . clay et al . postulated that hemosuccus pancreaticus is usually preceded by an episode of pancreatitis , which may occur several years prior to the episode of bleeding . the rapid ductal distension that occurs as blood enters the pancreatic duct leads to herald pain prior to onset of clinical bleeding . this increased pressure in the pancreatic duct allows the leak to seal by clot formation . hence , in order to diagnose hemosuccus pancreaticus , visceral angiogram should ideally be performed at the onset of epigastric pain , when extravasation of contrast from the splanchnic artery into the pancreatic duct can be observed . if the angiogram is delayed until onset of clinical bleeding , the diagnosis may be missed . other etiologies for hemosuccus pancreaticus include erosion of a pseudocyst into a peripancreatic artery in patients with chronic pancreatitis , direct bleeding from the pancreatic duct as a result of pancreatic duct stones , primary aneurysm of a splenic artery , blunt or penetrating abdominal trauma , mycotic aneurysms , and rarely pancreatic malignancy . clinical presentation includes recurrent episodes of herald pain localized in the epigastric region , followed by gastrointestinal bleeding , presenting as hematemesis , melena or hematochezia [ 4 , 12 ] . patients can present with hemodynamic instability and require multiple units of packed red cell transfusion . the diagnosis may often be delayed several years after initial presentation due to the intermittent nature of bleeding and failure to consider hemosuccus pancreaticus in the differential diagnosis of obscure gastrointestinal bleeding [ 4 , 10 ] . the overall mortality rate has been reported to be as high as 28% . in the era of video capsule endoscopy and double balloon enteroscopy , it is common to identify incidental findings in the small bowel , which in turn may lead to unnecessary endoscopic and surgical interventions , with their associated risk . video capsule endoscopy has been shown to identify abnormalities in up to 23% of healthy subjects . data from studies evaluating double balloon enteroscopy have noted inconsistent verification of video capsule findings in 1935% of patients and detection of incidental findings [ 17 , 18 ] . similarly , laparotomy without a precise diagnosis can lead to unnecessary small bowel resections , with a high rate of recurrent bleeding in up to 52% of patients . it is hence extremely important to consider extraluminal etiologies in the differential diagnosis of obscure gastrointestinal bleeding , and to maintain a high index of suspicion in order to establish a diagnosis of hemosuccus pancreaticus . visceral angiography is useful to confirm the site of bleeding and demonstrate a fistula between the pancreatic duct and peripancreatic vessels , with a sensitivity of 67100% [ 20 , 21 ] . sentinel clot sign , characterized by presence of blood clots in the pancreatic duct on ct scan , may also provide a clue to the diagnosis . three - dimensional ct angiography in addition to establishing the diagnosis allows evaluation of details including size of the aneurysm and surrounding viscera , and is hence useful in determining the appropriate therapeutic intervention [ 12 , 23 ] . however , ct interpretation by a radiologist with expertise in vascular radiology is extremely important to avoid missing subtle vascular findings . there have been isolated case reports of the diagnosis being made on endoscopy   or endoscopic retrograde cholangiopancreaticography , when blood is seen emanating from the ampulla of vater . in addition , the diagnosis may be established in hemodynamically unstable patients at the time of exploratory laparotomy . conventional treatment of hemosuccus pancreaticus secondary to a splenic artery pseudoaneurysm involves distal pancreatectomy and splenectomy , with no reported failure rate . in comparison , ligation of the splenic artery alone provides adequate treatment without vascular compromise , but has a reported failure rate of 43% [ 9 , 12 ] . transcatheter embolization by interventional radiology is a less invasive technique that involves embolization of the aneurysm using gelfoam or platinum spirals . this method of treatment is highly operator dependent , and may rarely be complicated by rebleed , splenic infarction , splenic or pancreatic abscess [ 9 , 15 ] . surgical resection may be more effective in the management of splenic artery pseudoaneurysms with associated pseudocysts , due to difficulty in embolization of large pseudocyst cavities . mycobacteria chelonae / abscessus group are ubiquitous , rapidly growing mycobacteria , and are associated with infections in both the immunocompromised and the immunocompetent patient . skin and soft tissue infections , infections complicating intravascular catheters , medical procedures or trauma , and less commonly this patient likely relapsed due to persistent intravascular infection , as suggested by a rapid relapse of the catheter - associated bacteremia and dissemination to multiple musculoskeletal sites , the negative echocardiogram notwithstanding . optimal treatment of m. chelonae / abscessus infections is difficult and ill defined , since these organisms are resistant to first line antituberculous and other antibacterial medications . successful treatment may require the administration of multiple antimicrobial agents to which the organism is susceptible , since single drug therapy has been associated with the emergence of resistance . tigecycline is a new glycylcycline agent with good activity against the rapidly growing mycobacteria , especially m. chelonae / abscessus group , and may be a useful component of a multiple drug regimen . although mycotic aneurysms have been reported to occur secondary to mycobacterium tuberculosis , there are no reports of aneurysms secondary to the rapid growing mycobacteria , including mycobacterium chelonae / abscessus . in our patient , fite stain of the splenic artery aneurysm was negative for acid fast organisms , confirming that the aneurysm was not related to the co - existent mycobacterial infection . it is important to consider the diagnosis of hemosuccus pancreaticus in patients with obscure gastrointestinal bleeding . angiography should ideally be performed at the onset of herald pain in order to detect extravasation of contrast from the splanchnic vessel into the pancreatic duct . a high index of suspicion should be maintained for extraluminal etiologies of obscure bleeding in order to avoid misdiagnosis and unnecessary endoscopic and surgical interventions in the era of video capsule endoscopy and double balloon enteroscopy .
hemosuccus pancreaticus is a rare etiology of obscure gastrointestinal bleeding characterized by bleeding into the pancreatic duct . 
 the diagnosis may be delayed for months to years , due to the episodic nature of bleeding and failure to consider the diagnosis . 
 patients often undergo multiple endoscopies and radiologic evaluations prior to diagnosis . 
 incidental gastrointestinal findings may lead to unnecessary endoscopic and surgical interventions . 
 this report describes a patient with hemosuccus pancreaticus diagnosed in the era of video capsule endoscopy and double balloon enteroscopy , whose management was complicated by multifocal mycobacteria chelonae / abscessus infection .