tourette syndrome ( ts ) is a childhood neuropsychiatric disorder characterized by motor and phonic tics . ts is often complicated by behavioral disorders such as attention - deficit hyperactivity disorder ( adhd ) , obsessive - compulsive disorder ( ocd ) , and anxiety and emotional disorders . approximately one - third of ts patients engage in self - injurious behaviors . as a self - limited disease , while ts symptoms are often controlled effectively via behavioral and drug therapies , conventional therapy does not work for a small number of patients . since 1995 , researchers have been working toward the use of stereotactic surgery in the treatment of ts . in 1999 , bilateral subthalamic deep brain stimulation ( dbs ) was first applied in the treatment of ts with substantial efficacy . subsequently , researchers have attempted the use of dbs for the treatment of ts with various targets . this study was conducted at the department of functional neurosurgery at xuanwu hospital , capital medical university . we performed globus pallidus internus ( gpi ) dbs on 25 patients with drug - resistant ts and conducted follow - up assessments of 24 of the patients for over 1 year . twenty - five patients with refractory ts were admitted to our hospital for treatment between september 2007 and august 2014 . following the electrode placement surgery , specifically , he experienced severe anxiety when the dbs stimulator was turned on . because of this side effect and the observation that dbs produced no remarkable improvement in ts symptoms , the patient requested that the stimulator to be switched off . as this patient refused to undergo a procedure to adjust the electrode position , we excluded him from our research sample . thus , the study population included 24 patients : 22 male and two female individuals aged 1841 years ( mean age : 25.3  6.4 years ) with an average medical history of ts of 14.7 years ( 821 years ) . most of the patients had comorbid disorders , including ocd ( 18 cases ) , adhd ( 16 cases ) , emotional disorder ( 15 cases ) , and self - injury behavior ( three cases ) . all patients met the diagnostic criteria for ts as per the diagnostic and statistical manual of mental disorders , 4 edition , text revision ( dsm - iv - tr ) and exhibited complex motor tics complicated with phonic tics . the diagnostic confidence index ( dci ) scores for the participant group ranged from 58 to 96 ( 77.71  12.12 ) [ table 1 ] . surgical procedures were performed according to the declaration of helsinki and were approved by the institutional review board at xuanwu hospital . baseline clinical characteristics and dbs complications of the 24 patients with tourette syndrome one patient experienced a mild sexual dysfunction , subcutaneous fluid accumulation , and infection in the ipg site . diplopia , flashing , fatigue , dizziness , and limb convulsions were observed as transient complications and disappeared following adjustment the stimulation parameters and electrode settings . dbs : deep brain stimulation ; dci : diagnostic confidence index ; ygtss : yale global tic severity scale ; adhd : attention deficit hyperactivity disorders ; ed : emotional disorder ; ocd : obsessive - compulsive disorder ; sib : selfinjury behavior ; ipg : implantable pulse generator . the surgical inclusion criteria were as follows : ( 1 ) ts diagnosis according to diagnostic and statistical manual of mental disorders , 4 edition , text revision criteria and the dci , ( 2 ) chronic and severe tic disorder with severe functional impairment , ( 3 ) the patient had not responded to adequate doses of three classes of drugs administered for at least 12 weeks each or could not tolerate medications because of side effects , and ( 4 ) the patient was over 18 years of age . our exclusion criteria barred patients whose tic disorder was attributable to another medical , psychiatric , or neurological disease , those with severe cardiovascular , pulmonary , or hematological disorders , and those with cerebral structural abnormalities from participation . we first performed magnetic resonance scanning ( 1.5 tesla , siemens , germany ) and identified the three - dimensional coordinates of the posterior ventral globus pallidus according to the schaltenbrand after placing the patient under local anesthesia with mild sedation , we created a 2.5 cm long incision in the scalp , starting 2.5 cm from the coronal suture and running parallel to the midline . after drilling a hole in the skull , we ensured that the dura mater had been coagulated before opening it via a cruciate incision . using a high - impedance microelectrode with a tip diameter of 12 m , we recorded extracellular discharges 10 mm above the target and confirmed the tissue characteristics . a dbs device ( model 3387 , medtronic , minneapolis , mn we then incised the retroauricular and subclavian regions and implanted the connecting wire and implantable pulse generator ( ipg , kinetra 7428 or soletra 7426 ) . we conducted bilateral gpi stimulation in twenty patients and unilateral gpi stimulation in four other patients who could not afford bilateral stimulation device or whose symptoms affected only one side . the dbs devices were switched on 1 week after surgery in a unipolar stimulation mode . the stimulation parameters included a pulse width of 90120 s , frequency of 65185 hz , and amplitude of 2.53.7 v. the stimulation parameters were individually adjusted according to the extent of symptomatic improvement and degree of side effects with the goal of obtaining an optimal treatment with minimal side effects . patients continued the use of any medications they had been treated with before the surgery . the follow - up data were compiled by an assessment group that was independent from the surgical group . the severity scores for motor tics , phonic tics , overall damage , and global tics were assessed based on the yale global tic severity scale ( ygtss ) . the assessments were performed 1 week before the surgery and 3 , 6 , and 12 months after the surgery . the symptoms of ocd were assessed using the yale - brown obsessive - compulsive scale ( y - bocs ) . surgical safety was evaluated by means of the wechsler adult intelligence scale - revised in china ( wais - rc ) . the postoperative improvement rate of symptoms was calculated as follows : improvement rate = ( preoperative ygtss score  postoperative ygtss score)/preoperative ygtss score  100% . all statistical analyses were performed using the statistical software package spss version 17.0 ( ibm statistics , chicago , il , usa ) . statistical differences were assessed through a one - way analysis of variance ( anova ) using the student  newman keuls test for post hoc comparisons after assessing the normality of data distribution . a criterion of p < 0.05 was used for statistical significance . twenty - five patients with refractory ts were admitted to our hospital for treatment between september 2007 and august 2014 . following the electrode placement surgery , specifically , he experienced severe anxiety when the dbs stimulator was turned on . because of this side effect and the observation that dbs produced no remarkable improvement in ts symptoms , the patient requested that the stimulator to be switched off . as this patient refused to undergo a procedure to adjust the electrode position , we excluded him from our research sample . thus , the study population included 24 patients : 22 male and two female individuals aged 1841 years ( mean age : 25.3  6.4 years ) with an average medical history of ts of 14.7 years ( 821 years ) . most of the patients had comorbid disorders , including ocd ( 18 cases ) , adhd ( 16 cases ) , emotional disorder ( 15 cases ) , and self - injury behavior ( three cases ) . all patients met the diagnostic criteria for ts as per the diagnostic and statistical manual of mental disorders , 4 edition , text revision ( dsm - iv - tr ) and exhibited complex motor tics complicated with phonic tics . the diagnostic confidence index ( dci ) scores for the participant group ranged from 58 to 96 ( 77.71  12.12 ) [ table 1 ] . surgical procedures were performed according to the declaration of helsinki and were approved by the institutional review board at xuanwu hospital . baseline clinical characteristics and dbs complications of the 24 patients with tourette syndrome one patient experienced a mild sexual dysfunction , subcutaneous fluid accumulation , and infection in the ipg site . diplopia , flashing , fatigue , dizziness , and limb convulsions were observed as transient complications and disappeared following adjustment the stimulation parameters and electrode settings . dbs : deep brain stimulation ; dci : diagnostic confidence index ; ygtss : yale global tic severity scale ; adhd : attention deficit hyperactivity disorders ; ed : emotional disorder ; ocd : obsessive - compulsive disorder ; sib : selfinjury behavior ; ipg : implantable pulse generator . the surgical inclusion criteria were as follows : ( 1 ) ts diagnosis according to diagnostic and statistical manual of mental disorders , 4 edition , text revision criteria and the dci , ( 2 ) chronic and severe tic disorder with severe functional impairment , ( 3 ) the patient had not responded to adequate doses of three classes of drugs administered for at least 12 weeks each or could not tolerate medications because of side effects , and ( 4 ) the patient was over 18 years of age . our exclusion criteria barred patients whose tic disorder was attributable to another medical , psychiatric , or neurological disease , those with severe cardiovascular , pulmonary , or hematological disorders , and those with cerebral structural abnormalities from participation . we used a crw human stereotactic instrument ( radionics inc . , usa ) for location orientating . we first performed magnetic resonance scanning ( 1.5 tesla , siemens , germany ) and identified the three - dimensional coordinates of the posterior ventral globus pallidus according to the schaltenbrand , we created a 2.5 cm long incision in the scalp , starting 2.5 cm from the coronal suture and running parallel to the midline . after drilling a hole in the skull , we ensured that the dura mater had been coagulated before opening it via a cruciate incision . using a high - impedance microelectrode with a tip diameter of 12 m , we recorded extracellular discharges 10 mm above the target and confirmed the tissue characteristics . a dbs device ( model 3387 , medtronic , minneapolis , mn , usa ) was implanted intracranially and fixed in place . we then incised the retroauricular and subclavian regions and implanted the connecting wire and implantable pulse generator ( ipg , kinetra 7428 or soletra 7426 ) . we conducted bilateral gpi stimulation in twenty patients and unilateral gpi stimulation in four other patients who could not afford bilateral stimulation device or whose symptoms affected only one side . the dbs devices were switched on 1 week after surgery in a unipolar stimulation mode . the stimulation parameters included a pulse width of 90120 s , frequency of 65185 hz , and amplitude of 2.53.7 v. the stimulation parameters were individually adjusted according to the extent of symptomatic improvement and degree of side effects with the goal of obtaining an optimal treatment with minimal side effects . patients continued the use of any medications they had been treated with before the surgery . the follow - up data were compiled by an assessment group that was independent from the surgical group . the severity scores for motor tics , phonic tics , overall damage , and global tics were assessed based on the yale global tic severity scale ( ygtss ) . the assessments were performed 1 week before the surgery and 3 , 6 , and 12 months after the surgery . the symptoms of ocd were assessed using the yale - brown obsessive - compulsive scale ( y - bocs ) . surgical safety was evaluated by means of the wechsler adult intelligence scale - revised in china ( wais - rc ) . the postoperative improvement rate of symptoms was calculated as follows : improvement rate = ( preoperative ygtss score  postoperative ygtss score)/preoperative ygtss score  100% . all statistical analyses were performed using the statistical software package spss version 17.0 ( ibm statistics , chicago , il , usa ) . statistical differences were assessed through a one - way analysis of variance ( anova ) using the student  newman keuls test for post hoc comparisons after assessing the normality of data distribution . a criterion of p < 0.05 was used for statistical significance . among 24 cases , 18 patients experienced a lesion - like effect after the dbs surgery and exhibited varying symptomatic improvement ranging from 10% to 80% ( self - assessment ) . when the lesion - like effect disappeared 37 days later , such that the symptoms had completely reappeared , we switched the dbs on . the follow - up data were obtained over a period of more than 12 months ( ranging from 12 to 99 months ) after the operation [ table 2 ] . at the 3-month follow - up assessment , six of the patients reported that they had received no benefit from the stimulation while the remaining 18 cases exhibited varying degrees of symptom amelioration . , we found a significant improvement in four types of ygtss scores from 3 months onward . the final follow - up data ( > 12 months ) are not presented in table 2 . ygtss : yale global tic severity scale ; sd : standard deviation . at the 6-month follow - up assessment , all patients had significantly improved symptoms and 56% of patients had a significant decrease in ygtss scores compared with the baseline ( p < 0.01 ) . at the 12-month follow - up , symptom improvements tended to be stable ( ygtss scores had improved by 57.8% from baseline , p < 0.01 ) . the average improvement of motor tics , phonic tics , social impairment , and global scores were 53.7% , 48.1% , 64.8% , and 57.8% , respectively . particularly , the mean score of global impairment was reduced to 14.2 points , which suggested that the social function of the patients was significantly improved . at the 12-month follow - up assessment , self - evaluations indicated that symptoms had improved by 50%80% after the dbs surgery , with an average improvement of approximately 70% . the improvement reflected by the self - assessment was higher than that of the ygtss score . this might be because the patients felt that their active control over tics had greatly increased after operations , such that the associated symptoms , such as emotional disorders and ocd , decreased as well . the y - bocs reflected a decrease in obsessive - compulsive tendencies at the 3 and 6-month follow - up assessments . we found a statistical difference between baseline score and scores at 3 , 6 , and 12 months . at the 12-month follow - up , y - bocs scores had stabilized such that they were similar to those at 6 months , with an average improvement of 38.59% compared with baseline [ figure 1 ] . y - bocs scores before and after gpi - dbs in ts patients . compared with baseline values , y - bocs scores were statistically lower at 3 , 6 , and 12-month follow - up assessments . * p < 0.01 versus baseline . y - bocs : yale - brown obsessive - compulsive scale ; gpi : globus pallidus internus ; dbs : deep brain stimulation ; ts : tourette syndrome . the mean preoperative scores from the wais - rc were as follows : the verbal intelligence quotient ( viq ) was 98.04  7.87 , the performance - iq ( piq ) was 99.21  7.26 , and the full - iq ( fiq ) was 98.30  6.74 . at the 12-month follow - up assessment , the mean viq , piq , and fiq scores were 100.08  7.71 , 99.29  7.32 , and 99.88  7.21 , respectively . there were no significant changes before versus after the surgery in any of the patients [ figure 2 ] . we found no significant difference between viq , piq , and fiq scores at baseline , 3 , 6 , and 12-month assessments . wais - rc : wechsler adult intelligence scale - revised in china ; gpi : globus pallidus internus ; dbs : deep brain stimulation ; ts : tourette syndrome ; viq : verbal intelligence quotient ; piq : performance - iq ; fiq : full - iq . at the early stage of dbs - on ( immediately after the stimulator had been turned on ) , temporary complications included diplopia , flashing , fatigue , dizziness , and limb convulsions . by adjusting the stimulation parameters and electrode settings , we found that these transient complications could be eliminated . one patient reported mild sexual dysfunction 3 months after the dbs had been switched on , and his dbs device was removed because of infection in the ipg site happening at 23 months after the operation . another patient also experienced postoperative subcutaneous fluid accumulation in the ipg pocket , which , although improved by puncture and aspiration at 12 months , finally resulted in infection 22 months postoperation and subsequent removal of the implanted device . a similar incident occurred in a third patient 26 months after the surgery whose tics began to mildly deteriorate following the removal of his ipg and electrode . among 24 cases , 18 patients experienced a lesion - like effect after the dbs surgery and exhibited varying symptomatic improvement ranging from 10% to 80% ( self - assessment ) . when the lesion - like effect disappeared 37 days later , such that the symptoms had completely reappeared , we switched the dbs on . the follow - up data were obtained over a period of more than 12 months ( ranging from 12 to 99 months ) after the operation [ table 2 ] . at the 3-month follow - up assessment , six of the patients reported that they had received no benefit from the stimulation while the remaining 18 cases exhibited varying degrees of symptom amelioration . , we found a significant improvement in four types of ygtss scores from 3 months onward . the final follow - up data ( > 12 months ) are not presented in table 2 . ygtss : yale global tic severity scale ; sd : standard deviation . at the 6-month follow - up assessment , all patients had significantly improved symptoms and 56% of patients had a significant decrease in ygtss scores compared with the baseline ( p < 0.01 ) . at the 12-month follow - up , symptom improvements tended to be stable ( ygtss scores had improved by 57.8% from baseline , p < 0.01 ) . the average improvement of motor tics , phonic tics , social impairment , and global scores were 53.7% , 48.1% , 64.8% , and 57.8% , respectively . particularly , the mean score of global impairment was reduced to 14.2 points , which suggested that the social function of the patients was significantly improved . at the 12-month follow - up assessment , self - evaluations indicated that symptoms had improved by 50%80% after the dbs surgery , with an average improvement of approximately 70% . the improvement reflected by the self - assessment was higher than that of the ygtss score . this might be because the patients felt that their active control over tics had greatly increased after operations , such that the associated symptoms , such as emotional disorders and ocd , decreased as well . the y - bocs reflected a decrease in obsessive - compulsive tendencies at the 3 and 6-month follow - up assessments . we found a statistical difference between baseline score and scores at 3 , 6 , and 12 months . at the 12-month follow - up , y - bocs scores had stabilized such that they were similar to those at 6 months , with an average improvement of 38.59% compared with baseline [ figure 1 ] . y - bocs scores before and after gpi - dbs in ts patients . compared with baseline values , y - bocs scores were statistically lower at 3 , 6 , and 12-month follow - up assessments . * p < 0.01 versus baseline . y - bocs : yale - brown obsessive - compulsive scale ; gpi : globus pallidus internus ; dbs : deep brain stimulation ; ts : tourette syndrome . the mean preoperative scores from the wais - rc were as follows : the verbal intelligence quotient ( viq ) was 98.04  7.87 , the performance - iq ( piq ) was 99.21  7.26 , and the full - iq ( fiq ) was 98.30  6.74 . at the 12-month follow - up assessment , the mean viq , piq , and fiq scores were 100.08  7.71 , 99.29  7.32 , and 99.88  7.21 , respectively . there were no significant changes before versus after the surgery in any of the patients [ figure 2 ] . we found no significant difference between viq , piq , and fiq scores at baseline , 3 , 6 , and 12-month assessments . wais - rc : wechsler adult intelligence scale - revised in china ; gpi : globus pallidus internus ; dbs : deep brain stimulation ; ts : tourette syndrome ; viq : verbal intelligence quotient ; piq : performance - iq ; fiq : full - iq . at the early stage of dbs - on ( immediately after the stimulator had been turned on ) , temporary complications included diplopia , flashing , fatigue , dizziness , and limb convulsions . by adjusting the stimulation parameters and electrode settings , we found that these transient complications could be eliminated . one patient reported mild sexual dysfunction 3 months after the dbs had been switched on , and his dbs device was removed because of infection in the ipg site happening at 23 months after the operation . another patient also experienced postoperative subcutaneous fluid accumulation in the ipg pocket , which , although improved by puncture and aspiration at 12 months , finally resulted in infection 22 months postoperation and subsequent removal of the implanted device . a similar incident occurred in a third patient 26 months after the surgery whose tics began to mildly deteriorate following the removal of his ipg and electrode . approximately 30%40% of ts patients experience complete remission after puberty whereas another 30% experience further deterioration with aging . some ts patients do not respond to treatment with systematic drugs or behavioral therapy and , thus , search for alternative treatments . indeed , some symptoms might last into adulthood , making ts a life - long disease . the management of patients with malignant ts can be very challenging , to the extent that some individuals might opt for surgical treatments . since then , a variety of surgical methods have been tested , leading to a large body of literature concerning possible ts mechanisms and treatments . in 1999 , vandewalle et al . described the first use of dbs for the treatment of ts . according to the literature , the thalamus and globus pallidus were selected as stimulation targets in the vast majority of patients . the average amount of tic improvement following dbs is generally 60%70% while a few studies have reported rates as high as 90%100% . there does not appear to be a significant therapeutic difference between stimulation of the thalamus or globus pallidus although stimulation of the anterior limb of the internal capsule and nucleus accumbens seems to be less effective ( 25%50% ) for treating ts . however , these sites might impact emotion ( stimulating different regions can cause feelings of depression or anxiety ) . thus , these regions might be useful targets in the treatment of severe affective disorders . a large number of studies have suggested that the basal ganglia play an important role in the pathophysiology of ts . according to the basal ganglia - thalamus - cortex loop theory described by mink , dysfunction of this loop leads to ts symptoms . therefore , dbs stimulation of the globus pallidus or thalamus , which are positioned in this loop , could bidirectionally regulate abnormal impulses in the striatum and thalamus . dysfunctions in the limbic striatal loop and orbitofrontal cortex - medial thalamic nuclei loop are associated with the onset of ts and ocd . as projections from the frontal thalamus and frontal striatum pass through the anterior limb of the internal capsule , dbs of this region might have therapeutic benefit . in this study , we treated 24 ts patients with gpi - dbs and conducted follow - up assessments for over 12 months . before the surgery , our patients responded poorly to conventional medication and psychological - behavioral treatment . at the 12-month follow - up assessment , we found that the motor and phonic tics had significantly improved in all 24 patients . specifically , gpi - dbs was effective for rapid and transient motor tics ( clonic tics ) , phonic tics , and slow and sustained movements ( dystonic tics ) . the impulse to move ( sensory tics or premonitory urge ) was also significantly alleviated by the surgery in this patient group . social impairment scores were reduced by 64.8% , indicating restored social function in the patient population . in addition , we found varying degrees of improvement in comorbid disorders , such as ocd , self - injury behavior , and emotional disorders ( testiness and irritability ) , after the surgery . a study investigating quality of life in ts patients after gpi - dbs obtained similar findings and concluded that symptomatic improvement might lead to unexpected major psychosocial changes . in our study , we observed an improvement in both tic and ocd symptoms in our patient population . the improvement in ocd symptoms that we found is similar to the outcome reported for the use of ventral capsule / ventral striatum as dbs targets for treatment of ocd . since it can be difficult to completely distinguish ocd symptoms from tics in ts patients with comorbid ocd , it might be difficult to discern the mechanisms underlying the observed improvement . therefore , it still needs more evidence for concluding that gpi is an appropriate target for ocd treatment based on this study . overall , our data indicate that bilateral gpi - dbs can be used to effectively regulate abnormal nerve impulses in the basal ganglia - related loop , thereby ameliorating tics and various accompanying symptoms in patients with ts , and improve patients quality of life with no significant changes in their intelligence or personality . the incidence of complications associated with dbs generally exceeds 25% , and 4%6% of these complications are permanent . in our study , a total of three patients encountered long - term postoperative surgical complications , which correspond to 12.5% of the participant group . the case of mild sexual dysfunction ( reduced sexual drive ) in one patient requires further investigation . two patients demonstrated skin erosion and subsequent infection at the ipg site who both engaged in robust athletic exercise after the operation . it is possible that the long - term and high - intensity friction from physical activity led to broken skin and infection in this area . compared with the disabling symptoms and refractory nature of ts , milder complications such as fatigue , a mild decrease in sex drive , and focal dystonia might be seen as acceptable . therefore , the application of dbs to the treatment of ts seems appropriate and efficacious . the application of dbs in the treatment of refractory ts has gained increasing attention in the academic community . in addition to the anterior limb of the internal capsule and the nucleus accumbens , all further surgery targets have been found to have good efficacy . recently , a double - blind , randomized , crossover trial provided additional evidence that dbs in the gpi can significantly improve tics . however , the study had a small number of patients , a short follow - up period , and inconsistent assessment criteria , making it difficult to ascertain the optimal therapeutic approach . indeed , the use of standard treatment criteria and assessment measures , as well as complete follow - up data , is essential for identifying new targets and improving surgical efficacy . in addition , since dbs is a reversible ( i.e. , patients return to the preoperative state a few hours after switching off the stimulator ) procedure , the combination of dbs with modern imaging techniques such as functional magnetic resonance imaging , positron emission computed tomography , and single photon emission computed tomography might greatly contribute to investigations of the pathophysiological basis of ts ( such as dopamine metabolism in the cortex - striatum - thalamus - cortex loop in the basal nucleus and dopamine receptor abnormality ) . first , this study as an open research project lacks randomized , double - blind , safety / efficacy study design and thus can not exclude the possibility of placebo effect . second , the follow - up study lasted for only 1 year , and longer - term effect was not available . in addition , this study is limited by the lack of a comparison target of stimulation , and it is insufficient to conclude that gpi serves as the optimal stimulation target . postoperative neuroimaging study would be helpful in future research to further delineate the relationship between actual stimulation area and treatment effect . this project was supported by a grant from national natural science foundation of china ( no . first , this study as an open research project lacks randomized , double - blind , safety / efficacy study design and thus can not exclude the possibility of placebo effect . second , the follow - up study lasted for only 1 year , and longer - term effect was not available . in addition , this study is limited by the lack of a comparison target of stimulation , and it is insufficient to conclude that gpi serves as the optimal stimulation target . postoperative neuroimaging study would be helpful in future research to further delineate the relationship between actual stimulation area and treatment effect . this project was supported by a grant from national natural science foundation of china ( no .
background : deep brain stimulation ( dbs ) has been a promising treatment for patients with refractory tourette syndrome ( ts ) for more than a decade . despite successful dbs treatment of ts in more than 100 patients worldwide , studies with a large patient sample and long - term follow - up 
 assessments are still scarce . 
 accordingly , we investigated the clinical efficacy and safety of globus pallidus internus ( gpi ) dbs in the treatment of intractable ts in 24 patients with a 1-year follow - up assessment.methods:bilateral/unilateral gpi - dbs was performed in 24 patients with ts . 
 we evaluated symptoms of tics and obsessive - compulsive disorder ( ocd ) through the yale global tic severity scale ( ygtss ) and yale - brown obsessive - compulsive scale ( y - bocs ) . 
 we used the wechsler adult intelligence scale - revised in china ( wais - rc ) to evaluate the safety of the treatment . 
 we conducted follow - up assessments of all patients for at least 12 months ( 1299 months).results : symptoms of tics and ocd were significantly relieved at a 12-month follow - up assessment . 
 the mean ygtss score was 74.04  11.52 , 49.83  10.91 , 32.58  7.97 , and 31.21  8.87 at baseline , 3 , 6 , and 12 months , respectively . 
 the mean ygtss scores obtained at the follow - up assessments were significantly different from the baseline ( p < 0.05 ) . 
 the improvement in motor tics was superior to that in phonic tics . 
 the mean y - bocs scores were 21.61  4.97 , 18  4.58 , 14.39  3.99 , and 13.78  4.56 at baseline , 3 , 6 , and 12 months , respectively ( p < 0.05 ) . 
 we observed a remarkable improvement in psychiatric comorbidities , such as ocd and attention - deficit hyperactivity disorder , after the procedure . 
 wais - rc scores were comparable before and after the operation . 
 there were no severe postoperative complications.conclusion:gpi-dbs appears to comprehensively alleviate tic symptoms and psychiatric comorbidities in patients with ts , thus significantly improving patients quality of life .