cervical spondylosis is a common cause of chronic neck pain , radiculopathy and/or myelopathy resulting in significant disability . when patients do not respond to conservative therapy , anterior cervical discectomy and fusion ( acdf ) usually is used to achieve neural decompression , maintain cervical lordosis , and provide segmental stabilization . in our practice , it was often found that patients with cervical spondylosis tended to have concomitant cervical vertigo symptoms such as tinnitus , headache , blur vision , and palpitation . recent studies have indicated that cervical spondylosis patients with cervical vertigo symptoms could be managed successfully with acdf . in this study , we report 2 cases of cervical spondylosis with concomitant cervical vertigo and hypertension that were treated successfully with acdf . this study obtained the approval of the medical ethics committee of our hospital ( general hospital of armed police force , beijing , china ) . case 1 , a 49-year - old female , was admitted with 2 years of history of chronic neck pain , headache , and episodic vertigo and tinnitus . episode occurred 1 to 2 times every day , and lasted 1 to 2  h each time . she felt numbness of both upper extremities and weakness of all 4 extremities for 1 year . physical examination showed that limited neck motion , slightly diminished sensation in both arms , and brisk deep tendon reflexes . radiographic examination of the cervical spine showed mild diminution in the height of the c5/6 disc space ( figure 1 ) . magnetic resonance imaging ( mri ) scan showed cord compression by a large central herniation of c5/6 disc with signs of myelomalacia ( figure 2 ) . lateral radiograph of cervical spine before operation showed slight narrowing of the c5/6 disc space . t2-weighted sagittal magnetic resonance imaging ( mri ) revealed a large herniation of c5/6 disc before operation , with marked compression of cervical cord , resulting in myelomalacia . the patient had a 2-year history of hypertension , blood pressure was 160/100  mmhg at onset , and then controlled in the normal range ( 110130/7080  mmhg ) by oral medications ( betaloc , 100  mg , once daily ; enalapril , 10  mg , once daily ) . case 2 , a 60-year - old male , was admitted with 10 years of history of chronic neck pain and stiffness . he also experienced vertigo , palpitation , nausea and vomiting with noted numbness of upper limbs , and heaviness of 4 limbs for over 6 months before admission . radiographic examination of the cervical spine revealed large anterior and posterior spur formation at the c5/6 and c6/7 disc levels , severe diminution in the height of the c5/6 disc space , and moderate diminution in the height of the c6/7 disc space . mri scan showed cervical canal stenosis with marked cord compression secondary to spondylotic changes in c5/6 and c6/7 discs . the patient had a 1-year history of hypertension ( maximum at 180/120  mmhg ) , which was controlled within the normal range by oral medications ( irbesartan , 150  mg , once daily ; nifedipine sustained release tablets , 20  mg , once daily ; amlodiping besylate , 5  mg , once daily ) . cervical spondylotic myelopathy was diagnosed and subsequently cervical anterior surgery was recommended for the 2 patients preoperatively based on clinical findings consistent with imaging study . case 1 underwent acdf at the c5/6 disc level ( figures 3 and 4 ) . after surgery , strength in all 4 limbs was significantly recovered , and symptoms of neck pain , headache , vertigo , and tinnitus disappeared . interestingly , her blood pressure also dropped to within the normal range after surgery even without oral medications . lateral radiograph of cervical spine 3 months after operation showed anterior cervical plate fixation with cage fusion at c5/6 disc level . t2-weighted sagittal magnetic resonance imaging ( mri ) 7 days after operation showed disappearance of cord compression at c5/6 disc level . his symptoms of cervical vertigo completely disappeared , numbness of both upper limbs significantly released , and muscle strength of 4 limbs obviously increased . similarly to case 1 , her cervical vertigo never recurred , and her blood pressure remained normal without the use of antihypertensive medications . case 2 has undergone a follow - up of 14 months , the patient never had cervical vertigo anymore , and his blood pressure remained normal throughout ( 120130/7585  mmhg ) . clinical results indicated that acdf can eliminate the concomitant vertigo symptoms in the 2 patients . however , the exact mechanisms of resolution of symptoms can not be elucidated precisely . because cervical spondylosis is a common disease , vertigo occurred in patients with cervical spondylosis is of particular importance . one previous study showed that vertigo was present in 50% of patients with cervical spondylosis , whereas another study identified cervical spondylosis as the cause of dizziness in 65% of elderly patients . it has been shown that the patients with cervical spondylosis complaining of vertigo have significant lower blood flow parameters than non - vertigo patients with cervical spondylosis . insufficient blood supply to posterior circulation is called vertebrobasilar insufficiency . the most common complaint in patients with vertebrobasilar insufficiency insufficient blood supply does not necessarily cause symptoms if there is sufficient collateral circulation , whereas a full range of symptoms commonly occur as a result of an insufficient terminal vessel . the vascular supply to the vestibulocochlear organ , being an end artery , makes this organ more susceptible to vertebrobasilar insufficiency . neurons , axons , and hair cells in the vestibulocochlear system are known to respond to ischemia by depolarizing , causing transient hyperexcitability with ectopic discharges , manifesting as tinnitus , vertigo , and dizziness . it was hypothesized that vertebral artery insufficiency secondary to cervical spondylosis could result in vertigo . however , the mechanisms of vertigo caused by cervical spondylosis are not clear so far . the mechanical compression on vertebral artery from spurs of the luschka joint was considered as a main mechanism . the reduction of vertebral artery flow can be more obvious with the rotation and hyperextension of the head . in our current study in addition , mechanical compression can not explain some other symptoms such as palpitation , nausea , vomiting , etc . recent clinical studies by hong et al and li et al demonstrated that the stimulation of the sympathetic nerve fibers other than the compression of the vertebral artery induces these symptoms such as vertigo , tinnitus , nausea , and vomiting . current study clearly indicates that hypertension can be associated with cervical spondylosis , as a secondary condition . we speculate that the mechanisms of hypertension induced by cervical spondylosis could be the same as that of cervical vertigo . it is well known that cervical disc , dura mater , and posterior longitudinal ligament are rich in sympathetic fibers . sympathetic nerve fibers distributed around the vertebral artery have been implicated in the autoregulation of vertebrobasilar artery blood flow and cerebral blood flow . it has been evidenced that sympathetic nerve activity withdraws the blood flow , whereas sympathectomy can increase it . a previous study investigated sympathetic and parasympathetic changes incited by the stimulation of nerves around the proximal vertebral artery in cat model and found subsequent papillary changes , pulse and blood pressure changes . elevation in levels of inflammatory cytokines has been detected in painful discs of humans , and thought to be related to degeneration and pain . the pathogenic change in the painful disc is featured with the formation of zones of vascularized granulation tissue and extensive innervation extending from the outer layer of the annulus fibrosus into the nucleus pulposus . degenerative changes in the disc , such as loss of the normal structure and a mechanical load , can lead to abnormal motion , which can provoke mechanical stimulation . mechanical stimuli , which are normally innocuous to disc nociceptors can , in certain circumstances such as inflammation , generate an amplified response termed peripheral sensitization . the vertebral arteries are mainly innervated by nerve fibers from the cervical sympathetic ganglia ( 13 ) . innervation in cervical disc is analogous to that in the lumbar spine , receiving innervation posteriorly from the sinuvetebral nerves , laterally from the vertebral nerve , and anteriorly from the sympathetic trunks . recently , an animal study   revealed a reciprocal neural connection between cervical spinal and sympathetic ganglia . it seems likely that stimulation of sympathetic nerve fibers in the pathologically degenerative disc and surrounding tissues produce sympathetic excitation , and induce a sympathetic reflex to cause vertebrobasilar insufficiency and hypertension . improvement of neurological function , resolution of vertigo , and recovery of blood pressure following surgery could be attributed to the excision of degenerative and herniated cervical disc , the decompression of the dura mater and posterior longitudinal ligament , and the stabilization of degenerated segment . chronic neck pain is one of the major symptoms in patients with cervical spondylosis , whereas some studies have indicated that resting blood pressure levels may be elevated in patients with persistent pain . in healthy individuals , these interactions are believed to reflect a homeostatic feedback loop that helps restore arousal levels in the presence of acutely painful stimuli . a role for baroreceptors in this feedback loop appears likely , with pain triggering sympathetically driven blood pressure increases , resulting in increased stimulation of baroreceptors , which in turn activates descending pain inhibitory pathways . previous studies suggested that blood pressure / pain regulatory relationship may be substantially altered in chronic pain conditions . a retrospective study by bruehl et al suggested that chronic pain could be associated with increased risk of hypertension . their study found that over 39% of patients with chronic pain were diagnosed with clinical hypertension , compared with only 21% of pain - free internal medicine patients . they thought that chronic pain - related impairments in overlapping systems modulating both pain and blood pressure would result in a higher prevalence of clinically diagnosed hypertension in patients with chronic pain than in comparable pain - free patients . our study indicates a possible relation between chronic neck pain and hypertension . if chronic neck pain could lead to hypertension through sympathetic arousal and failure of normal homeostatic pain regulatory mechanisms , early treatment for resolution of chronic neck pain may have a beneficial impact on cardiovascular disease risk in patients with cervical spondylosis we report here 2 patients of cervical spondylosis with concomitant cervical vertigo and hypertension that were treated successfully with anterior cervical discectomy and fusion . stimulation of sympathetic nerve fibers in pathologically degenerative disc could produce sympathetic excitation , and induce a sympathetic reflex to cause cervical vertigo and hypertension . in addition , chronic neck pain could contribute to hypertension development through sympathetic arousal and failure of normal homeostatic pain regulatory mechanisms . early treatment for resolution of symptoms of cervical spondylosis may have a beneficial impact on cardiovascular disease risk in patients with cervical spondylosis .
abstractcervical spondylosis and hypertension are all common diseases , but the relationship between them has never been studied . 
 patients with cervical spondylosis are often accompanied with vertigo . 
 anterior cervical discectomy and fusion is an effective method of treatment for cervical spondylosis with cervical vertigo that is unresponsive to conservative therapy . 
 we report 2 patients of cervical spondylosis with concomitant cervical vertigo and hypertension who were treated successfully with anterior cervical discectomy and fusion . 
 stimulation of sympathetic nerve fibers in pathologically degenerative disc could produce sympathetic excitation , and induce a sympathetic reflex to cause cervical vertigo and hypertension . 
 in addition , chronic neck pain could contribute to hypertension development through sympathetic arousal and failure of normal homeostatic pain regulatory mechanisms.cervical spondylosis may be one of the causes of secondary hypertension . 
 early treatment for resolution of symptoms of cervical spondylosis may have a beneficial impact on cardiovascular disease risk in patients with cervical spondylosis .