more than 40,000 people die from falls globally.1 adults aged > 65 years have the highest risk of death or severe injury after falls . approximately 30% of older people fall each year and the frequency exponentially increases with age.24 falls not only profoundly impact a persons health but also bring huge economic burden . for older people , falls accounted for 10%15% of emergency visits and up to 50% of severe injury - related hospitalizations.5,6 the occurrence of falls results from a complex interaction of multiple determinants , including older age , gender , chronic illness , poor vision , lack of exercise , impaired cognition , environmental factors , and lower socioeconomic level.7 the environmental factor , responsible for 30%50% of falls for older people , might be the most crucial among these factors because it encapsulates the interaction of individual factors with the surroundings.8 different residential environments accordingly result in distinct risk of falls for older people . a previous study has reported that older adults living in rural areas had 36% higher odds of self - reported past - year fall - related injuries than those living in urban areas ( odds ratio = 1.36 , 95% confidence interval [ ci ] = 1.061.75).9 as rural and urban older people have numerous health - related disparities , leading to disproportionate incidence of health problems in rural older people , we are interested in whether the mortality after falls also varies between rural and non - rural areas.10,11 however , nonfatal falls result in considerable morbidity , including dependence , immobilization , and decreased function.12 it has been reported that the 1-year mortality rate was 22% in older people with a hip fracture after a fall and was 24.5% in those with a cervical fracture after a fall.13 therefore , to understand the potential factors predisposing the death after falls would be helpful for developing appropriate fall prevention programs . in this study , we investigated the mortality rate after falls of rural and non - rural older people and explored the risk factors of mortality after falls among older people . control study by using the data from the national health insurance research database ( nhird ) in taiwan . the nhird comprises the medical records from the single - payer national health insurance ( nhi ) program , which covers more than 99% of residents in taiwan . in this study 1 ) a rural group , was identified from the inpatient database of yilan county from 2006 to 2009 . , 3,897 older people were hospitalized due to accidental falls and , therefore , were grouped as the rural group . 2 ) a non - rural group , was extracted from a longitudinal cohort database , comprising 128,359 older inhabitants from all townships in taiwan . among these older people , 5,541 were hospitalized for accidental falls and were grouped as the non - rural group . both groups were followed up for 4 years after falls for the all - cause mortality . according to the criteria adopted by the nhird , the rurality of taiwan townships is defined by the following characteristics : population density , ratio of people with educational levels higher than college , ratio of people older than 65 years , ratio of people who are agriculture workers , and the number of physicians per 100,000 people . these criteria have led to the classification of yilan county of taiwan as a rural area.14 this study was ethically approved by the institutional review board in national yang - ming university hospital . the diagnoses of hospitalization were coded by the international classification of diseases , ninth revision , clinical modification ( icd-9-cm ) . if the number of falling episodes was more than two during the study period , only the first one would be taken as the index episode . however , due to the high and full coverage of nhi , people in taiwan only exit insurance when they die . three major variables were considered as the potential risk factors of mortality after falls , including demographic factor , comorbidity , and medications . the comorbidity was evaluated by the charlson comorbidity index to reflect the severity of disease because older people tend to have multiple chronic disorders . we coded the ambulatory prescriptions 3 months prior to falls according to the anatomical therapeutic chemical classification ( level 4 ) and calculated the number of medications . the standard of inappropriate medication use was the 2012 beers criteria , which provides the list of drugs that should be avoided in older people . it would be considered as inappropriate medication use if an older person took any drugs that are on the list 3 months before their fall . the continuous variables were presented as mean ( standard deviation ) and the categorical variables were presented as count ( percentage ) . to compare the characteristics between the two groups , a two - sampled t - test and chi - square test were used for continuous variables and categorical variables , respectively . a logistic regression model was used in a multivariate analysis for risk factors of mortality after falls . all databases were managed by microsoft sql server 2012 ( redmond , wa , usa ) , and the statistical analyses were performed using ibm spss statistics for windows , version 19.0 ( ibm corporation , armonk , ny , usa ) . control study by using the data from the national health insurance research database ( nhird ) in taiwan . the nhird comprises the medical records from the single - payer national health insurance ( nhi ) program , which covers more than 99% of residents in taiwan . in this study 1 ) a rural group , was identified from the inpatient database of yilan county from 2006 to 2009 . , 3,897 older people were hospitalized due to accidental falls and , therefore , were grouped as the rural group . 2 ) a non - rural group , was extracted from a longitudinal cohort database , comprising 128,359 older inhabitants from all townships in taiwan . among these older people , 5,541 were hospitalized for accidental falls and were grouped as the non - rural group . both groups were followed up for 4 years after falls for the all - cause mortality . according to the criteria adopted by the nhird , the rurality of taiwan townships is defined by the following characteristics : population density , ratio of people with educational levels higher than college , ratio of people older than 65 years , ratio of people who are agriculture workers , and the number of physicians per 100,000 people . these criteria have led to the classification of yilan county of taiwan as a rural area.14 this study was ethically approved by the institutional review board in national yang - ming university hospital . the diagnoses of hospitalization were coded by the international classification of diseases , ninth revision , clinical modification ( icd-9-cm ) . if the number of falling episodes was more than two during the study period , only the first one would be taken as the index episode . however , due to the high and full coverage of nhi , people in taiwan only exit insurance when they die . three major variables were considered as the potential risk factors of mortality after falls , including demographic factor , comorbidity , and medications . the comorbidity was evaluated by the charlson comorbidity index to reflect the severity of disease because older people tend to have multiple chronic disorders . we coded the ambulatory prescriptions 3 months prior to falls according to the anatomical therapeutic chemical classification ( level 4 ) and calculated the number of medications . the standard of inappropriate medication use was the 2012 beers criteria , which provides the list of drugs that should be avoided in older people . it would be considered as inappropriate medication use if an older person took any drugs that are on the list 3 months before their fall . the continuous variables were presented as mean ( standard deviation ) and the categorical variables were presented as count ( percentage ) . to compare the characteristics between the two groups , a two - sampled t - test and chi - square test were used for continuous variables and categorical variables , respectively . a logistic regression model was used in a multivariate analysis for risk factors of mortality after falls . all databases were managed by microsoft sql server 2012 ( redmond , wa , usa ) , and the statistical analyses were performed using ibm spss statistics for windows , version 19.0 ( ibm corporation , armonk , ny , usa ) . among the 52,544 older inhabitants of a rural area in taiwan , 3,897 people experienced at least one hospitalization due to an accidental fall during 20062009 . the frequency in the rural area was significantly higher than that in the non - rural area ( 7.4% [ 3,897 of 52,544 ] vs 4.3% [ 5,541 of 128,359 ] , p<0.001 ) . the comparison of the rural group and the non - rural group was presented in table 1 . the rural group was significantly younger ( 76.4 years vs 77.8 years , p<0.001 ) , had a greater charlson comorbidity index ( 2.2 vs 2.1 , p<0.001 ) , and took more medications ( 13.7% vs 12.5% , p<0.001 ) than the non - rural group . the proportion of inappropriate medication use was also higher in the rural group ( 38.7% vs 36.6% , p=0.07 ) , but the difference did not achieve statistical significance . by further analyzing the hospitalization of older people in the rural area , although the causes of fall - related hospitalization differed between the rural and non - rural groups , it did not achieve a statistically significant difference . the most frequent complication in the rural area was femur fracture ( 23.8% ) , followed by head injury ( 14.1% ) and upper extremity fracture ( 13.0% ) . the most frequent cause of fall - related hospitalizations in a non - rural area was a hip fracture ( 24.9% ) , followed by upper extremity fracture ( 15.7% ) and other fractures ( 15.5% ) . the 4-year cumulative all - cause mortality rate after a fall in the non - rural group was 23.4% ( 95% ci = 22.124.7 ) , which was significantly higher than that of the rural group ( 8.8% ) ( 95% ci = 7.99.8 ) . the independent risk factors of mortality after falls included male , older age , non - rural area , severer comorbidity , higher number of medications taken , and presence of inappropriate medication use . after adjusting for age , gender , comorbidity , number of medications , and inappropriate medication use , the rural group had a significantly lower risk of mortality after falls than the non - rural group ( adjusted odds ratio = 0.32 , 95% ci = 0.280.37 , p<0.001 ) ( table 2 ) . rural and non - rural areas are distinct in terms of socioeconomic condition , surrounding environment , and the accessibility to health services.15 the urban  rural difference also leads to some health - related disparities.10,11,16 it has been noted that rural older people fall more frequently than urban older people . but seldom have studies compared the mortality after falls for older people between different places of residence . additionally , as the risk factors of falls have been analyzed thoroughly , it would be helpful to further understand the potential factors predisposing the mortality after falls.1,8,9,1719 in this study , we found that the rural older people had a significantly lower mortality , even after more frequent falls . the first was the lower incidence of fractures in the rural area , which has been similarly reported in many countries.2026 most investigators suggested that the difference of fracture incidence could be explained by the higher bone mineral density ( bmd ) of a rural population.2123,2730 a population - based 15-year cohort study of females aged 50 years in sweden reported that the rural population had significantly higher bmd , lower prevalence of osteoporosis , and lower incidence of hip fractures.21 a study in norway , which included 7,333 females aged 65 years , found that urban females had a higher rate of forearm fractures , and the authors commented that this was due to the lower forearm bmd of urban females than that of rural females.22 therefore , as fracture is the major cause of fatal falls , the rural population might have less morbidity and less mortality even after more frequent falls because of their higher bmd and their lower incidence of fractures.3133 the second was the rural  urban difference of industrial distribution . according to the government statistics in taiwan , the percentage of the agricultural population in yilan county at the end of 2009 was approximately 25% , which was almost twice than that in all of taiwan ( 13%).34,35 the rural group in this study consequently comprised of farmers who usually spend the majority of their time undertaking outdoor physical activity even after falls . previous studies have revealed that early mobilization in older people after fractures could enhance functional recovery and reduce mortality , and mobility function was the independent risk factor for recurrence falls.3638 therefore , the rural older people might recover earlier after falls and have less morbidity and mortality than the non - rural older people . previous studies report that environment - related factors and weather could impact the occurrence of falls in older people.8,39 according to government statistics in taiwan , there were more single storied houses but less buildings with elevators in yilan county.15 additionally , the area of a house is larger and the weather is more wet and humid in yilan county.15,40 the different home surroundings , environments , and weather between the rural and urban areas consequently lead to different etiologies of falls . for example , rural older people might have more chance of slipping outdoors or falling from indoor stairs , but less chance of stumbling inside their home or on a street . these different etiologies of falls , which usually result in diverse types of injuries , could explain the rural  urban difference of mortality after falls . in addition to the place of residence , this study also noted that males , comorbidity , number of medications taken , and the use of inappropriate medication were also the independent risk factors of mortality after falls . the results were concordant with the reported predictors of death after a hip fracture in older people.4143 as hip fractures accounted for the major cause of death after falls , it is reasonable to find similar risk factors of mortality between falls and hip fractures . 1 ) the fall episode was identified by fall - related hospitalization and fall - related outpatient care was included . therefore , selection bias might not be avoided and the incidence of falls would be underestimated . 2 ) some fall - related variables were not taken into consideration , for example , the reasons of falls and the place of falls . several individual factors , which might impact on the prognosis of falls , were also not included , such as education level , body mass index , and bmd . 3 ) due to the limitation of the claim database , we did not calculate the frequency of multiple injuries . rural older people had a higher frequency of fall - related hospitalizations but lower mortality after falls than non - rural older people . the place of residence is an independent risk factor of death after falls for older people .
objectivethis study aimed to investigate the mortality rate after falls of rural and non - rural older people and to explore the risk factors of mortality after falls among older people.patients and methodsthis population - based case 
 control study identified two groups from a nationwide claim database ( national health insurance research database in taiwan ) : a rural group and a non - rural group , which included 3,897 and 5,541 older people , respectively , who were hospitalized for accidental falls ( the international classification of diseases , ninth revision , clinical modification : e880e888 ) during 20062009 . 
 both groups were followed up for 4 years after falls . 
 four - year cumulative all - cause mortality rate after falls was calculated , and the demographic factor , comorbidity , and medications were considered as the potential risk factors of mortality after falls.resultsthe rural group had a significantly higher frequency of fall - related hospitalizations ( 7.4% vs 4.3% , p<0.001 ) , but a lower 4-year cumulative all - cause mortality rate after falls than the non - rural group ( 8.8% vs 23.4% , p<0.001 ) . after adjusting for age , gender , comorbidity , and medication use , 
 the rural group had a significantly lower risk of mortality after falls than the non - rural group ( adjusted odds ratio = 0.32 , 95% confidence interval = 0.280.37 , p<0.001 ) . 
 age , gender , place of residence , comorbidity , number of medications , and inappropriate medication use were independent risk factors of mortality after falls.conclusionthe rural older people had a higher frequency of fall - related hospitalizations but lower mortality after falls than the non - rural older people . 
 fall prevention programs should be adjusted for difference in place of residence .