Best of 2Pac ni albamu vibao vikali vilivyotolewa baada ya kufa kwa msanii wa muziki wa hip hop Tupac Shakur. Kompilesheni hii imetolewa katika sehemu mbili: Thug na Life. Albamu zote mbili zilitolewa mnamo tar. 4 Desemba katika mwaka wa 2007 huko nchini Marekani na 10 Desemba 2007 nchini Uingereza, ikaja kuvuja mnamo tar. 30 Novemba. Kwa mwezi wa Mei 2008, zaidi ya nakala 121,000 za Thug zimeuzwa nchini Marekani, wakati Life imeuza zaidi ya nakala 90,550. "2 of Amerikaz Most Wanted" (akishirikiana na Snoop Doggy Dogg) "California Love" (Original) (akishirikiana na Dr. Dre, Roger Troutman) "So Many Tears" "I Ainot Mad at Cha" (akishirikiana na Danny Boy) "How Do U Want It?" (akishirikiana na K-Ci na JoJo) "Trapped" "Changes" (akishirikiana na Talent) "Hail Mary" (akishirikiana na Outlawz) "Unconditional Love" "Dear Mama" (Remix) (akishirikiana na Anthony Hamilton) "Resist the Temptation" (akishirikiana na Amel Larrieux) "Definition of a Thug Nigga" "Still Ballin'" (Nitty Remix) (akishirikiana na Trick Daddy)