Mahamadou Issoufou (wuxuu dhashay Janaayo 1, 1951) waa siyaasi reer Niger ah oo isagu ahaa Madaxweynaha Niger ilaa 7dii Abril 2011. Issoufou wuxuu ahaa Raiisel Wasaaraha Niger intii u dhaxeysay 1993 ilaa 1994, Madaxweynaha Golaha Qaranka 1995 ilaa 1996, wuxuuna leeyahay Wuxuu ahaa musharrax doorasha kasta oo madaxweye ilaa iyo 1993. Wuxuu hogaaminayay Xisbiga Niger ee Dimuqraadiyada iyo Soshiyaaldiyada (PNDS-Tarayya), oo ah xisbi dimuqraadiyadeed bulsheed, laga soo aasaasay 1990 ilaa loo doortey inuu noqdo madaxweynaha 2011. Xilligii Madaxweynihii Mamadou Tandja ( 1999–2010), Issoufou wuxuu ahaa hogaamiyaha ugu weyn mucaaradka.