1621 (MDCXXI) ebile ngwaga wa go thoma ka Labohlano, ngwaga wa bobedi ngwagengsome wa 1620s, ngwaga wa bomasomepedi tee ngwagengkgolo wa Ngwagakgolo 17, le ngwaga wa bomakgolo tshela masomepedi tee ngwagengkete wa Ngwagakete 2.