1221 (MCCXXI) ebile ngwaga wa go thoma ka Labohlano, ngwaga wa bobedi ngwagengsome wa 1220s, ngwaga wa bomasomepedi tee ngwagengkgolo wa Ngwagakgolo 13, le ngwaga wa bomakgolo pedi masomepedi tee ngwagengkete wa Ngwagakete 2.