Dị ka akụkụ a na-apụghị izere ezere nke ịka nká, mmepụta na ngosipụta nke homonụ n'ime ahụ na-ebelata kwa afọ, na-ebute enweghị ahaghị nhata nke homonụ. N'ihe banyere enweghị ahaghị nhata nke homonụ, akụkụ ahụ gị niile na-arụ ọrụ nke ọma na nrụgide, na-ebute oke ibu, bloating, ike ọgwụgwụ, isi ike nkwonkwo, na mfu anụ ahụ. Usoro ọgwụgwọ nnọchi homonụ bioidentical bụ ụzọ nke nwere ike ibelata mgbaàmà nke ọdịda homonụ na-ebute ma ọ bụ enweghị ahaghị nhata. N'ime usoro ọgwụgwọ a nke nwetagoro ọtụtụ nlebara anya n'oge na-adịbeghị anya, a ga-ejupụta ọkwa nke homonụ na-agwụ agwụ n'ime ahụ gị site na iji homonụ bioidentical nwere nhazi ya na homonụ nke ahụ gị na-emepụta n'onwe ya. Dịka ekwuru, homonụ bioidentical nwere usoro kemịkal ahụ dị ka homonụ nke ahụ mmadụ mere. Okwu a bu "bioidentical" na-ezo aka na nhazi nke homonụ kama isi mmalite nke homonụ. Maka homonụ agbakwunyere iji megharịa ọrụ nke homonụ endogenous nke emepụtara na nhazi ya n'ime ahụ, usoro kemịkalụ kwesịrị kwekọọ na nke mbụ ya.