Kofi Abrefa Busia (11 ga Yuli 1913 - 28 ga Agusta 1978) ya kasance jagoran siyasar Ghana kuma masanin ilimi wanda ya kasance Firayim Minista na Ghana daga 1969 zuwa 1972. A matsayinsa na shugaba mai kishin ƙasa da firaminista, ya taimaka wajen dawo da gwamnatin farar hula zuwa ƙasar bayan mulkin soja. An haifi Busia a matsayin basaraken Bono a masarautar gargajiya ta Wenchi, a Yankin Brong Ahafo, ɗaya daga cikin Yankunan Gold Coast guda huɗu, sannan a ƙarƙashin mulkin Biritaniya kuma yanzu ake kira Ghana. Ya yi karatu a Makarantar Methodist, Wenchi, Makarantar Mfantsipim, Cape Coast, sannan a Kwalejin Wesley, Kumasi, daga 1931 zuwa 1932. Ya yi koyarwa a Kwalejin Wesley kuma ya bar karatu da koyarwa a Kwalejin Achimota. Ya sami digirinsa na farko tare da Daraja a Medieval da Tarihin zamani daga Jami'ar London, ta hanyar wasiƙa a wannan lokacin. Daga nan ya ci gaba da karatu a Kwalejin Jami'ar, Oxford, inda ya kasance ɗalibin ɗan Afirka na farko na kwaleji. Ya koma Gold Coast a 1942.