Hypercholesterolemia, wanda kuma ake kira high cholesterol, shine kasancewar yawan matakan cholesterol a cikin jini. Yana da nau'in lipids na jini mara kyau, tare da high triglycerides da low HDL cholesterol. Gabaɗaya babu alamun bayyanar. A lokuta masu tsanani xanthomas na iya faruwa. Matsalolin na iya haɗawa da cututtukan zuciya, bugun jini, da cututtukan jijiyoyin jini. Dalilan na iya haɗawa da cututtukan ƙwayoyin cuta kamar hypercholesterolemia na iyali. Yawancin lokuta; duk da haka, sun kasance saboda haɗuwa da abubuwan da ke tattare da kwayoyin halitta tare da abinci, rashin aiki, kiba da shan taba. Sauran abubuwan haɗari sun haɗa da ƙananan thyroid, ciwon nephrotic, cholestasis, barasa, ciwon sukari, da wasu magunguna kamar HCTZ. Bincike ya dogara ne akan gwaje-gwajen jini don gano babban adadin cholesterol ko LDL cholesterol. Jiyya yawanci ya ƙunshi canje-canjen salon rayuwa da magunguna. Canje-canjen salon rayuwa sun haɗa da motsa jiki da abinci mai kyau. Idan canje-canjen salon rayuwa bai wadatar ba, ana ba da shawarar magungunan statin sau da yawa. Sauran magungunan da za a iya amfani da su sun haɗa da ezetimibe, niacin, da masu hana PCSK9.