Lalla Malika Issoufou (an haife tane a ranar 14 ga watan Fabrairun shekarar 1975) likita ce yar asalin ƙasar Nijar, kuma majiɓinci da yawa na agaji. Ta yi aiki a matsayin Uwargidan Shugaban ƙasar Nijar, tare da Aatassata Issoufou Mahamadou, daga 7 ga Afrilu 2011 zuwa 2 Afrilu 2021 a matsayin matar shugaban Mahamadou Issoufou ta biyu . An haifi Lalla Malika Issoufou a ranar 14 ga Fabrairu 1975 a Niamey, Nijar. Ta yi digirin digirgir a fannin likitanci daga Jami’ar Abdou Moumouni kuma ta yi aiki a Asibitin Kasa da ke Yamai daga Janairun 2001 zuwa Satumba 2003. Issoufou ta yi karatu a jami’ar Paris Diderot a 2004-05 kuma an ba ta difloma a fannin kula da cutar kanjamau da sauran cututtukan da ake yadawa ta hanyar jima’i, ta kuma yi karatu a jami’ar Pierre da Marie Curie a 2005-06 kuma ta samu difloma a fannin ilimin wurare masu zafi . A watan Oktoba na 2011 aka nada ta shugabar Gidauniyar Tattali Iyali, wata kungiya mai zaman kanta da ke kula da cututtukan da ke yaduwa a Nijar.