An sanar da bullar COVID-19 ta farko a Afirka a Masar a ranar 14 ga Fabrairu, 2020. An aiwatar da matakan rigakafi da yawa a cikin ƙasashe daban-daban a Afirka, gami da hana tafiye-tafiye, soke jirgin sama, soke taron, rufe makarantu, da rufe kan iyaka. Sauran matakan da za a dauka da takaita yaduwar cutar sun hada da dokar hana fita, kulle-kulle, da kuma tilasta sanya abin rufe fuska . Kwayar cutar ta bazu ko'ina cikin nahiyar. Lesotho, kasa ta karshe mai cin gashin kanta ta Afirka da ta kasance ba ta da kwayar cutar, ta ba da rahoton bullar cutar a ranar 13 ga Mayu 2020. Eritrea ta ba da sanarwar dakatar da makonni uku, wanda ya fara a ranar 2 ga Afrilu don yakar yaduwar COVID-19. Saliyo ta ba da sanarwar cewa dokar hana fita ta kwanaki uku za ta fara aiki a ranar Asabar (4 ga Afrilu). Hukumar Kula da Ilimi ta Ghana da Zoomlion Ghana Limited sun hada karfi da karfe don kaddamar da wani shiri na fatattakar dukkan manyan makarantu na musamman da na fasaha a kasar don dakile yaduwar cutar.