Itsekiri (wanda kuma ake kira Isekiri, iJekri, Itsekri, Ishekiri, ko Itsekhiri ) ɗayan rukunin Yarbawa ne na yankin Niger Delta na Najeriya, Jihar Delta . Mutanen Itsekiri a yanzu suna da sama da mutane miliyan 3 kuma galibi suna rayuwa a cikin gundumomin ƙananan hukumomin Warri South, Warri North da Warri South West da ke jihar Delta a gabar Tekun Atlantika na Najeriya . Za a iya samun mahimman al'ummomin Itsekiris a wasu sassa na jihohin Edo da Ondo da kuma a wasu biranen Nijeriya da dama da suka haɗa da Lagos, Sapele, Benin City, Port Harcourt da Abuja . Mutane da yawa daga zuriyar Itsekiri suma suna zaune a ƙasar Ingila, Amurka da Kanada. The Itsekiris suna da kusanci sosai da Yarbawa na Kudu maso Yammacin Najeriya kuma mafi yawanci ga mutanen Urhobo (musamman Okpe) da mutanen Edo. Itsekiri a al'adance suna kiran ƙasarsu kamar Masarautar Warri ko 'Iwerre' a matsayin suna mai dacewa - wanda ke da alaƙa da yankin da gundumomin ƙananan hukumomin Warri uku suka mamaye.