Majalisar don Nazarin Kimiyya da Masana'antu (CSIR) an kafa ta ne ta hanyar NLC Decree 293 na 10 ga Oktoba 10, 1968 wanda NLCD 329 ta 1969 ta gyara, kuma aka sake kafa ta a cikin ta ta yanzu ta Dokar CSIR 521 a ranar 26 ga Nuwamba, 1996. Tunanin farko na Majalisar, ya samo asali ne daga tsohuwar Majalisar Bincike ta Kasa (NRC), wacce gwamnati ta kafa a watan Agusta 1958 don tsarawa da daidaita binciken kimiyya a Ghana. A cikin 1963, NRC ta haɗu da tsohuwar Kwalejin Kimiyya ta Ghana, ƙungiyar ilmantarwa ta doka. Bayan wani bita da aka yi a cikin 1966, aka sake kirkiro da kwalejin a cikin, a zahiri, gaɓaɓɓun ɓangarorinta na asali, wato ƙungiyar bincike ta ƙasa ta sake fasalin CSIR da learnedungiyar Ilimin da aka ƙaddara, aka ƙaddamar da Makarantar Kwalejin Fasaha da Kimiyya ta Ghana. Abubuwan da ke cikin Dokar 1996 ita ce girmamawar da aka ba kamfanoni masu zaman kansu, da kuma gabatar da ka'idojin kasuwa cikin ayyukan Majalisar ta hanyar kasuwancin bincike.