Ciwon daji epigenetics shine nazarin gyare-gyaren epigenetic zuwa DNA na kwayoyin cutar kansa wanda ba ya haɗa da canji a cikin jerin nucleotide, amma a maimakon haka ya haɗa da canji a yadda aka bayyana lambar kwayoyin halitta. Hanyoyin Epigenetic suna da mahimmanci don kula da jerin al'ada na takamaiman maganganun kwayoyin halitta na nama kuma suna da mahimmanci don ci gaba na al'ada. Wataƙila suna da mahimmanci, ko ma mafi mahimmanci, fiye da maye gurbin kwayoyin halitta a cikin canjin tantanin halitta zuwa kansa. Rikicin hanyoyin epigenetic a cikin cututtukan daji, na iya haifar da asarar bayyanar kwayoyin halittar da ke faruwa kusan sau 10 akai-akai ta hanyar yin shiru na rubutu (wanda ya haifar da haɓakar epigenetic hypermethylation na tsibiran CpG ) fiye da maye gurbi. Kamar yadda Vogelstein et al. nuna, a cikin ciwon daji na launin fata yawanci ana samun kusan maye gurbin direba 3 zuwa 6 da 33 zuwa 66 hitchhiker ko maye gurbin fasinja.