Safiyyah bint Huyayy (Larabci: صفية بنت حيي, c. 612–670) tana daya daga cikin matan Annabi Muhammadu. Ta kasance tare da dukkan sauran matan Muhammadu, mai suna Umm-ul-Mu'mineen ko kuma "Uwar Muminai". Bayan rasuwar Muhammadu, ta shiga cikin siyasar ikon al'ummar musulmin farko, kuma ta sami babban tasiri a lokacin rasuwarta. An haifi Safiyya a Madina ga Huyayy ibn Akhtab, shugaban kabilar Yahudawa Banu Nadir. Mahaifiyarta, Barra bint Samawal, ta fito daga kabilar Banu Qurayza. Ita jikar Samaw'al bn Adiya ce daga kabilar Banu Harith. A cewar wata majiya, an aurar da ita ga Sallam ibn Mishkam, wanda daga baya ya sake ta. Lokacin da aka kori Banu Nadir daga Madina a shekara ta 625, iyalinta suka zauna a Khaybar, wani wurin ruwa kusa da Madina. Mahaifinta da ɗan'uwanta sun tafi daga Khaybar don shiga cikin sojojin Makka da na Badawiyya da suka kewaye Muhammad a Madina a lokacin Yaƙin gwalalo. Lokacin da mutanen Makka suka janye Muhammad suka kewaye Banu Qurayza. Bayan shan kayen Banu Qurayza a shekara ta 627 mahaifin Safiyya, wanda ya dade yana adawa da Muhammad, Musulmai sun kama shi suka kashe shi.