A cikin likitanci, tunanin tsabtace jiki yana nuna cewa bayyanar yara da yara zuwa wasu ƙananan ƙwayoyin cuta kamar (gut flora da helminth parasites) yana kariya daga cututtukan rashin lafiyan ta hanyar ba da gudummawa ga ci gaban tsarin garkuwar jiki. Musamman, ana tsammanin rashin ɗaukar hotuna yana haifar da lahani a cikin kafa haƙuri da garkuwar jiki. Lokacin ɗaukar hoto zai fara ne daga utero kuma ya ƙare tun yana makaranta. Kalmar "Azamcin tsabtace azancin" an bayyana ta a matsayin mara ma'ana saboda mutane suna fassara shi da kuskure cewa yana nufin tsabtar mutum. An fara ba da shawarar alaƙar da ke tsakanin kamuwa da ƙwayoyin cuta da cututtukan rigakafi a shekarar 1968. Asalin asalin kirkirar tsabtar kiwon lafiya ya samo asali ne daga 1989, lokacin da David Strachan ya ba da shawarar cewa ƙananan kamuwa da cuta a ƙuruciya na iya zama bayani game da hauhawar cututtukan rashin lafiyan kamar asma da zazzaɓi a cikin ƙarni na 20. Stiemsma, Leah; Reynolds, Lisa; Turvey, Stuart; Finlay, Brett (July 2015). "The hygiene hypothesis: Current perspectives and future therapies". ImmunoTargets and Therapy.