Issa Lamine ɗan siyasan Nijar ne. Ya jagoranci Toubou -based Front Democratique Revolutionnaire, ɗaya daga cikin ƙungiyoyin 'yan tawaye da dama da ke aiki a arewa mai nisa da gabashin Nijar a karshen shekarun 1990s. Lamine ya shiga gwamnati a matsayin wakilin garin N'Gourti da ke gabashin ƙasar a shekarar 2000. A matsayinsa na memba na ƙungiyar dimokuradiyya da zamantakewar jama'a (CDS-Rahama), ya kasance Mataimakin a Majalisar Dokokin Nijar sannan ya yi aiki a gwamnatin Nijar a matsayin Ministan Kiwon Lafiyar Jama'a daga 2007 zuwa 2009. Ya bar CDS-Rahama a 2009 kuma an zabe shi ga Majalisar Dokoki ta kasa a matsayin ɗan takara mai zaman kansa . A ƙarshen shekarun 1990 Lamine ya kasance "Shugaban Harkokin Harkokin Waje", daga baya kuma ya kasance jagora gaba ɗaya, na ƙungiyar 'yan tawayen Front Democratique Revolutionnaire da ke zaune a Toubou da ke aiki a kudancin yankin Kaouar . Bayan juyin mulkin 1999 da komawa mulkin farar hula, Lamine ya zama jagoran siyasa daga sansaninsa da ke N'Gourti, kuma daga 5 ga Janairun 2000 ya zama Minista a jerin gwamnatoci.