Antoinette Sassou Nguesso (an haife ta a ranar 7 ga Mayu, 1945 a Brazzaville) malami ce 'yar Kwango mai ritaya kuma jigo a cikin jama'a wacce ta rike mukamin uwargidan shugaban kasar Jamhuriyar Kongo tun 1997 a matsayin matar Shugaba Denis Sassou Nguesso. Ta kuma rike mukamin uwargidan shugaban kasa daga shekarar 1979 zuwa 1992 a lokacin mulkin mijinta na farko na shugaban kasa. An haifi Sassou Nguesso Antoinette Loemba Tchibota a ranar 7 ga Mayu, 1945, a Brazzaville ga Pascal Loemba Tchibota da Marie-Louise Djembo. Iyayenta waɗanda ’yan asalin Kakamoéka ne, sun sake aurenta sa’ad da take ƙarama. Mahaifiyarta daga baya ta sake yin aure da mijinta na biyu, François Gallo Poto, kani ga Antoinette Gbetigbia Gogbe Yetene (d. 1977), matar farko ga Mobutu Sese Seko, Shugaban Zaire. Mahaifiyar Sassou Nguesso, wacce aka fi sani da Mama Poto Galo, ta rasu ne a watan Janairun 2005, kuma an binne ta a makabartar Gombe dake Kinshasa a makwabciyar kasar Kongo. Bayan rabuwar iyayenta, Sassou Nguesso ta girma a duka Pointe-Noire da Brazzaville.