Cleopatra Koheirwe ƴar wasan kwaikwayo ce, marubuci, mawaƙa kuma ƴar jarida ƴar ƙasar Uganda. Ta fara fitowa akan allo a matsayin Joy in The Last King of Scotland a cikin 2006. Tun daga wannan lokacin ta sami matsayi da yawa akan ayyukan fina-finai da talabijin daban-daban a cikin gida da na duniya ciki har da rawar kan Netflix's Sense8 a matsayin Uwa a cikin kakar 2. Cleopatra tana wasa Ebony a cikin sabon Nana Kagga wanda ya ba da umarni kuma ya samar da jerin Tunani tare da sauran mashahuran Uganda Malaika Nnyanzi, Housen Mushema, Andrew Kyamagero, Prynce Joel Okuyo da Gladys Oyenbot. Koheirwe ya shiga StarTimes Uganda a watan Yuni 2019 a matsayin sabon Manajan Hulɗa da Jama'a. A shekara ta 2001, ta shiga cikin shahararriyar ƙungiyar kiɗa, raye-raye da wasan kwaikwayo da ake kira Obsessions (yanzu Obsessions Africa) har zuwa Maris 2007 lokacin da ta yi murabus daga ƙungiyar don ci gaba a kan hanyarta. A cikin 2010, ta fara aiki a kan aikinta na rera waƙa bayan abokai da magoya bayanta sun ƙarfafa ta ta sake yin wasan.