Prempeh II (Otumfuo Nana Sir Osei Tutu Agyeman Prempeh II, KBE, c. 1892 - 27 May 1970), shine sha huɗu Asantehene, ko sarkin Ashanti (Mai Mulkin Asante), yana mulki daga 22 ga Yuni 1931 zuwa 27 ga Mayun 1970. An haifi Asantehene Prempeh II na Ashanti a 1892 a Kumasi babban birnin kasar. Yana ɗan shekara huɗu lokacin da kawunsa, Prempeh I (na 13 na Asantehene), kakan mahaifiyarsa, sarauniya Nana Yaa Akyaa, da sauran membobin dangi suka kama su kuma suka tura su zuwa Tsibirin Seychelles da Birtaniyya a 1896. Prempeh na dawo daga gudun hijira a 1924 kuma ya mutu a watan Mayu 1931, kuma daga baya aka zaɓi Otumfuo Prempeh II a matsayin wanda zai gaje shi; duk da haka, an zaɓe shi a matsayin Kumasihene kawai maimakon Asantehene. A cikin 1935, bayan ƙoƙari mai ƙarfi daga gare shi, hukumomin mulkin mallaka sun ba wa Prempeh II damar ɗaukar taken Asantehene. A cikin 1949 Prempeh II ya kasance mai taimakawa wajen kafa Kwalejin Prempeh, babbar makarantar yara maza da ke Kumasi, Ashanti.