Tarihi Daga Cherokee Land zuwa Gundumar Greenville Falls Park da McBee's Mill a cikin 1844. Ofasar Greenville ta yau ta kasance filin farauta na Cherokee, wanda aka haramta wa masu mulkin mallaka. Wani hamshakin mai kudi daga Virginia mai suna Richard Pearis ya isa South Carolina a wajajen 1754 kuma ya kulla dangantaka da Cherokee. Pearis yana da ɗa tare da matar Cherokee kuma ya karɓi eka dubu 100 (ar 40,000) daga Cherokee a kusa da 1770. Pearis ya kafa shuka a kan Kogin Reedy da ake kira Great Plains a cikin garin Greenville na yanzu. Juyin Juya Halin Amurka ya raba ƙasar Kudancin Carolina tsakanin Masu biyayya da Patan ƙasa. Pearis ya goyi bayan yalan Aminci kuma tare da ƙawayensu, Cherokee. Bayan Cherokee ya kai hari ga Patriots, Patriots sun rama ta hanyar kona gonar Pearis kuma suka kulle shi a Charleston. Pearis bai sake komawa gonarsa ba amma an kira sunan tsaunin Paris da shi.Yarjejeniyar Kusurwa ta Dewitt a cikin 1777 ta ba da kusan duk ƙasar Cherokee, gami da Greenville ta yau, zuwa South Carolina. An kirkiro gundumar Greenville ne a shekarar 1786.