Valproate (VPA) da valproic acid, sodium valproate, da valproate semisodium siffofin magunguna ne da farko da ake amfani da su don magance farfadiya da cututtuka na bipolar da kuma hana ciwon kai. Suna da amfani don rigakafin faɗuwar da cuta a cikin waɗanda ba su da faɗuwar rashi, faɗuwar ɓangarori, da faɗuwar gaba ɗaya. Ana iya ba su ta hanyar jini ko ta baki, kuma nau'ikan kwamfutar hannu suna wanzu a cikin tsari mai tsayi da gajere. Illolin valproate na yau da kullun sun haɗa da tashin zuciya, amai, bacci, da bushewar baki. Mummunan illa na iya haɗawa da gazawar hanta, don haka ana ba da shawarar saka idanu akai-akai na gwajin aikin hanta. Sauran manyan haɗari sun haɗa da pancreatitis da ƙara haɗarin kashe kai. An san Valproate yana haifar da mummunar rashin daidaituwa a cikin jarirai idan an sha a lokacin daukar ciki, kuma saboda haka ba a ba da shawarar ba ga matan da suka kai shekarun haihuwa waɗanda ke da migraines. Ba a san takamaiman tsarin aikin Valproate ba. Hanyoyin da aka tsara sun haɗa da rinjayar matakan GABA, toshe tashoshin sodium mai ƙarfin lantarki, da hana histone deacetylases.