Helen U. Esuene (an haife ta a 23 ga Nuwamba 1949) tsohuwar ma’aikaciyar Nijeriya ce wacce aka nada ta Karamar Ministar Lafiya, sannan daga baya ta zama Ministar Muhalli da Gidaje a Majalisar Shugaba Olusegun Obasanjo tsakanin 2005 da 2007. Tarhinta Helen Esuene ta yi kwasa-kwasan a Sirrin Sirri da Gudanar da Ofishi a Cibiyar Horar da Tarayya da ke Kaduna kuma ta fara aikin gwamnati a matsayin sakatariyar sirri. Daga baya ta yi kwasa-kwasan nesa daga Jami'ar Leicester kuma ta sami Msc a Kudi. Jim kaɗan bayan ta auri tsohon gwamnan soja na tsohuwar Jihar Kuros Riba, Cif Udokaha Esuene, wanda ya mutu a 1996. Sun haifi ’yan mata biyu da maza uku. Ta shiga harkar kasuwanci, inda ta fara da sarrafa albarkatun mutane don samar da Mobil. Daga baya ta fara abin da ya zama Villa Marina Hotel a Eket, wanda aka buɗe a 2000. Helen Essuene ta kasance ƴar takarar kujerar sanata mai wakiltar Akwa Ibom ta Kudu a zaɓen watan Afrilun 2011, tana tafiya ne a karkashin jam’iyyar PDP. https://allafrica.com/stories/200912140759.html