Kwalejin Prempeh makarantar kwana ce ta jama'a ga yara maza da ke Kumasi, babban birnin yankin Ashanti, Ghana. An kafa makarantar a cikin 1949 ta ikon gargajiya na Asanteman, Gwamnatin Mulkin Mallaka ta Burtaniya, Cocin Methodist Ghana da Cocin Presbyterian na Ghana. Sunan makarantar ne bayan Sarkin Ashanti, (Asantehene) Sir Osei Tutu Agyeman Prempeh II, wanda ya ba da kyautar filin da aka gina makarantar. kuma an tsara shi akan Kwalejin Eton a Ingila. Makarantar ta sami digiri na farko a Jami'ar Kimiyya da Fasaha ta Kwame Nkrumah a 2004 tare da dalibai 441 da kuma a 2012, tare da dalibai 296 daga kwalejin, kuma ana daukar su daya daga cikin mafi kyawun makarantun sakandare a Ghana. Makarantar ta lashe Gasar Robotics ta Kasa sau biyar a tsakanin 2013 da 2021. A shekarar 2016 Kwalejin Prempeh ta lashe lambar yabo ta Toyota Innovation Award a gasar cin kofin duniya ta Robofest na duniya da aka gudanar a Michigan, Amurka.