Obiageli Ezekwesili (an haife ta a ranar 28 ga watan Afrilu shekarar 1963), wanda aka fi sani da Oby Ezekwesili, wata kwararriyar akawun Najeriya ce daga jihar Anambra. Ta aka haife zuwa mahaifin Benjamin Ujubuonu wanda ya mutu a shekarar 1988 da kuma mahaifiyarsa, Cecilia Nwayiaka Ujubuonu wanda ya mutu a ranar 21 ga watan Yuni, na shekarar 2020. Tana auren Fasto Chinedu Ezekwesili na Redeemed Christian Church of God (RCCG). Ta kasance wacce ta kirkiro kungiyar Transparency International, tana aiki a matsayin daya daga cikin manyan daraktocin hukumar yaki da cin hanci da rashawa ta duniya da ke zaune a Berlin, Jamus. Ta yi aiki a matsayin Ministan Tarayya na Ma'adanai masu Dadi sannan daga baya ta zama Ministan Ilimi na Tarayya a lokacin shugabancin Olusegun Obasanjo a karo na biyu. Bayan haka, ta yi aiki a matsayin Mataimakin Shugaban Bankin Duniya na Bankin Afirka daga watan Mayu shekarar 2007 zuwa watan Mayu shekara ta 2012, sannan daga baya ta maye gurbin ta da Makhtar Diop. Ezekwesili ta kasance yar takarar neman lambar yabo ta Nobel ta Duniya saboda aikinta na nuna gaskiya a bangaren hakar ma'adinai.