tokens: Previously , our group reported mutations in the zink - binding domains L2 ( codons 163 - 195 ) and L3 ( codons 236 - 251 ) of p53 critical to DNA binding [ 12 ] to be associated with but not fully predictive for resistance to chemotherapy with a low - dose weekly anthracycline [ 13 ] or a mitomycin plus 5 - fluoro - uracil containing [ 14 ] regimen .