tokens: To do so , we sequenced the complete coding regions for the CHEK2 and p14 ( ARF ) genes and analyzed for p14 ( ARF ) promoter hypermetylations ; 3 ) Evaluate in vitro function of potential Chk2 and p14 ( ARF ) protein translates corresponding to identified mutations in the CHEK2 and p14 ( ARF ) genes ; 4 ) Identify potential TP53 , CHEK2 and p14 ( ARF ) mutations to be germline , explore the incidence of different cancers among affected relatives with respect to specific mutations .