U.S. Route 59 (US 59) is a north–south interstate highway in the United States. It goes parallel to U.S. Route 75 for almost its entire road, and it is never much more than  away for most of it.

The highway's northern terminus is  north of Lancaster, Minnesota, at the Canada–US border. From there, it continues as Manitoba Highway 59. Its southern terminus is at the Mexico–US border in Laredo, Texas. From there, it continues as Mexican Federal Highway 85D.

Major intersections
Texas
 World Trade International Bridge at the Mexico–US border
  in Laredo. The highways travel concurrently through the city.
  in Laredo
  in George West
  east of George West
  in Beeville
  in Goliad
  southwest of Victoria. I-69/US 59 will travel concurrently to Houston. US 59/US 77 travels concurrently to south-southwest of Victoria.
  in Victoria
  in Houston
  in Houston
  in Houston
  in Houston. I-69/US 59 will travel concurrently to Tenaha.
  in Livingston
  in Corrigan
  in Lufkin. The highways travel concurrently through the city.
  in Redfield
  in Timpson. The highways travel concurrently to Tenaha.
  in Tenaha. I-369/US 59 will travel concurrently to Texarkana.
  in Carthage. The highways travel concurrently to north of Carthage.
  in Marshall
  in Marshall
  in Texarkana. I-369/US 59 travels concurrently to I-30.
  in Texarkana
  in Texarkana
  in Texarkana. I-30/US 59 travels concurrently to the Arkansas state line.
Arkansas
  in Texarkana. US 59/US 71 travels concurrently to Acorn.
Texas
  north of Texarkana
Arkansas
  in Lockesburg. The highways travel concurrently to De Queen.
  in Saline Township. The highways travel concurrently to De Queen.
  in Wickes
  in Acorn. US 59/US 270 travels concurrently to Heavener, Oklahoma.
Oklahoma
  west-northwest of Page
  in Poteau. The highways travel concurrently to west of Spiro.
  in Sallisaw
  in Sallisaw. The highways travel concurrently through the city.
  in Westville
  in West Siloam Springs. The highways travel concurrently to Kansas.
  east-northeast of Afton. US 59/US 60 travels concurrently for approximately . US 59/US 69 travels concurrently to north of Dotyville.
  east-northeast of Afton
Kansas
  in Chetopa. The highways travel concurrently through the city.
  in Oswego. The highways travel concurrently to the Mount Pleasant–Fairview township line.
  in Parsons
  in Moran
  in Welda Township. The highways travel concurrently to Washington Township.
  in Ottawa. The highways travel concurrently to Ottawa Township.
  in Willow Springs Township
  in Lawrence. The highways travel concurrently through the city.
  in Lawrence
  in Lawrence. US 24/US 59 travels concurrently to Williamstown.
  in Shannon Township. The highways travel concurrently to Atchison.
Missouri
  in St. Joseph. The highways travel concurrently through the city.
  in St. Joseph
  in Jefferson Township
  in Nodaway Township
  in Jackson Township. The highways travel concurrently to Nodaway Township.
  in Hickory Township
  in Hickory Township
  in Union Township
  in Tarkio Township. The highways travel concurrently to Tarkio.
Iowa
  in Indian Creek Township
  in Belknap Township. The highways travel concurrently to Oakland.
  in Avoca
  in Denison. The highways travel concurrently through the city.
  on the Logan–Griggs township line. The highways travel concurrently to Holstein.
  on the Franklin–Lincoln township line. The highways travel concurrently to Sanborn.
Minnesota
  in Worthington
  in Custer Township
  in Camp Release Township. The highways travel concurrently to Montevideo.
  in Moyer Township
  on the Buse–Dane Prairie township line. The highways travel concurrently to Fergus Falls Township.
  in Detroit Lakes
  in Knute Township
  at the Canada–US border on the Richardville–St. Joseph township line

References

Other websites

Endpoints of US 59

U.S. Highways