Weston as a surname may refer to:

 Weston family, Canadian and United Kingdom business family:
Alannah Weston, daughter of Galen Weston and creative director of Selfridges 
George Weston, founder of Weston Bakeries
Galen Weston, Canadian businessman, son of W.G. Weston
Galen Weston, Jr., son of Galen Weston and head of Loblaws
Garry Weston, Canadian born British businessman, son of W.G. Weston
Guy Weston, British businessman, son of Garry Weston
George G. Weston, British businessman, son of Garry Weston
W. Garfield Weston, Canadian businessman and former British MP
 Aylmer Hunter-Weston (1864–1940), British general and politician
 Bob Weston, American musician
 Bob Weston (guitarist) (born 1947), English guitarist
 Brett Weston (1911–1993), American photographer
 Charles Weston, 3rd Earl of Portland (c.1639–1665), English nobleman
 Chris Weston, British comics artist
 Curtis Weston (born 1987), English footballer
 Doug Weston (c.1926/27–1999), American nightclub owner
 Edward Henry Weston (1886–1958), American photographer
 Dr Edward Weston (chemist) (1850–1936), English chemist, industrialist and founder of the Weston Electric Light Company and Weston Electrical Instrument Corporation
 Edward Faraday Weston (1878–1971), son of Edward Weston (chemist) and designer of the Weston exposure meter, which established the Weston film speed ratings
 Edward Payson Weston (1839–1929), American walker
 Sir Francis Weston (1513?–1536), English royal attendant
 Harold Weston (1894–1972), American modernist painter 
 Hilary Weston (born 1942), Irish-born Canadian businesswoman and politician 
 Jack Weston (1924–1996), American actor
 James A. Weston (1827–1895), American politician
 Jerome Weston, 2nd Earl of Portland (c.1605–1662), English nobleman
 Jessie Weston (1850–1928), British writer on Arthurian legend
 Joan Weston (1935–1997), American roller derby athlete
 Sir John Weston (born 1938), British diplomat and poet
 Joseph H. Weston (1911–1983), Arkansas newspaper editor and politician
 Kathy Weston (born 1958), American middle distance runner
 Kim Weston (born 1939), American soul singer
 Kris Weston (born 1972), British electronic musician
 Dame Margaret Weston (born 1926), British museum director
 Maria Weston Chapman (1806–1885), American abolitionist 
 Michael Weston (born 1973), American actor
 Neville Weston (born 1936), English Australian artist and art historian
 Paul Weston (1912–1996), American music arranger
 Percy Weston, played football for England in 1871 and 1872
 Phil Weston (born 1973), English cricketer
 Professor Weston, fictional C.S. Lewis character 
 Randy Weston (born 1926), American jazz pianist 
 Rhys Weston (born 1980), Welsh footballer
 Richard Weston, several people
 Riley Weston (born 1967), American actress
 Roz Weston, Canadian television personality
 Russell Eugene Weston Jr. (born 1956), American murderer
 Simon Weston (born 1961), Welsh soldier and Falkland Islands veteran
 Sir Weston, the 21st ghost Luigi encounters in Luigi's Mansion
 Steve Weston (died 1985), Canadian actor
 Thomas Weston (horticulturalist) (1866–1935), Australian horticulturalist and afforestation pioneer
 Thomas Weston (actor) (1737–1776), English actor
 Thomas Weston, 4th Earl of Portland (c.1609–1688), English nobleman 
 Tim Weston (born 1982), New Zealand cricketer
 Tommy Weston (1895–1952), English footballer who played for Aston Villa and Stoke City
 Walter Weston (1861–1940), English clergyman and mountaineer
 William Weston (Early English Navigator) (15th Century), English Navigator 
 William Weston (1804–1888), Australian politician
 William Basil Weston (c.1924–1945), British Army officer, awarded the Victoria Cross