This is a list of notable people born in, residents of, or otherwise closely associated with the city of Springfield, Missouri and its surrounding metropolitan area.

Politics
 John Ashcroft, former U.S. attorney general
 Matt Blunt, former governor of Missouri
 Melanie Blunt, former first lady of Missouri
 Roy Blunt, U.S. Senator
 Sempronius H. Boyd, former U.S. representative and ambassador to Siam
 Charlie Brown, former U.S. representative
 Jim Keet (born 1949), former member of both houses of the Arkansas legislature; the 2010 Republican gubernatorial nominee in Arkansas
Billy Long, U.S. Representative
 Roscoe Patterson, former U.S. senator and representative

Arts, literature, humanities and entertainment
 Lennie Aleshire, vaudeville and country music performer
 Bob Barker, former host of The Price Is Right
 Julie Blackmon, photographer
 Aaron Buerge, star of ABC's The Bachelor, season 2
 Kim Crosby, Broadway performer
 Ian Eskelin, lead singer of All Star United
 Ralph D. Foster, broadcasting pioneer
 William Garwood, actor
 John Goodman, actor (born in Affton and attended Missouri State University)
 Lucas Grabeel, actor, singer (High School Musical, HSM2, and HSM 3: Senior Year)
 Sara Groves, Christian contemporary recording artist
 Speedy Haworth, guitarist and singer
 Joe Haymes, swing era bandleader-arranger (born in Marshfield; grew up and began his band in Springfield)
 Tess Harper, actress (graduated from Missouri State University)
 Josh Heinrichs, reggae singer
 Jah Roots, reggae band
 Jay Kenneth Johnson, actor
 The Jordanaires, singing group
 King's X, musical group
 Chandler Lawson, beauty pageant titleholder, Miss Tennessee 2012
 Brenda Lee, singer (moved to Springfield in 1956 at age 11)
 Shelby Lindrose, Miss USA contender
 Jim Lowe, country music singer
 Robin Luke, musician
 The Marksmen, singing quartet (originally The Foggy River Boys)
 The Ozark Mountain Daredevils, musical group
 The Philharmonics, singing quintet
 Brad Pitt, actor
 Dana Powell, actress, Modern Family, The Office, Arrested Development, Suburgatory, Bridesmaids
 Ronnie Self, singer/songwriter
 Brittany Sicard, artist
 Scott Siman, music producer and executive
 Si Siman, music producer and broadcast executive
 Someone Still Loves You Boris Yeltsin, musical group
 Speakeasy, rock and roll band
 Patti Suarez newscaster, TV host, film and stage actress
 Terre Thaemlitz, musician, cultural producer
 Tony Tost, poet
 Kathleen Turner, actress
 Speedy West, steel guitarist and record producer
 Robert Westenberg, Broadway performer
 Adrienne Wilkinson, actress (graduated from Kickapoo High School)
 Slim Wilson, musician, radio and TV personality
 Daniel Woodrell, author

Sports

 Scott Bailes, former American League pitcher in the 1980s and 1990s; now the color commentator for the Springfield Cardinals baseball franchise
 Tyler Blaylock, NFL wide receiver
 Lori Endicott, 1996 Olympic volleyball player
 Gracie Gold, Olympic figure skater
 Ryan Howard, current MLB player, 2005 NL Rookie of the Year, 2006 Home Run Derby Champion, 2006 NL Most Valuable Player
 Jack Jewsbury, MLS player for the Portland Timbers
 Josh Kinney, first Springfield Cardinal (AA) to make the St. Louis Cardinals major league roster
 Stan Musial, Hall of Fame baseball player for the St. Louis Cardinals, played for the original Springfield Cardinals minor league baseball team in the late 1930s
 Larry Nemmers, NFL referee
 Steve Rogers, former MLB starting pitcher with Montréal Expos; most successful pitcher in  Expos history
Emily Scott, Olympian speed skater
 Payne Stewart, professional golfer
 Jackie Stiles, NCAA all-time leading scorer in women's basketball
 Anthony Tolliver, NBA basketball player for the Minnesota Timberwolves
 Paul Walker, football player

Business
John Morris, founder and majority owner, Bass Pro Shops
 Jack Gentry, World War II and Korean War veteran; founder of Positronic
David Glass, former CEO of Wal-Mart; owner of the Kansas City Royals
John Q. Hammons, founder of John Q. Hammons Hotels & Resorts
 Ryan Handy, 2010 Mr. Universe contestant; Playgirl magazine centerfold
 Charles F. O'Reilly (father) and Charles H. O'Reilly (son), founders of O'Reilly Auto Parts in 1957
 Jack Stack, founder of SRC Holdings
 Roy E. Winegardner, former CEO of Holiday Inns, partner with John Q. Hammons in Winegardner and Hammons

Other
 Jimmie Angel, aviator, discoverer of Angel Falls, the  ighest free-falling waterfall in the world
 J. Alan Groves, Biblical Hebrew scholar; editor of Groves-Wheeler Hebrew morphology database
 Edwin P. Hubble, of Hubble Space Telescope fame (born in Marshfield)
Virginia E. Johnson, sexologist; junior member of the Masters and Johnson sexuality research team
 Janet Kavandi, NASA astronaut
 Ryan P. Walsh, founder and Chief Technology Officer of the Walsh Foundations

Notes 

Lists of people from Missouri