Sam, SAM or variants may refer to:

Places
 SAM, IATA airport code for Salamo Airport in Papua, New Guinea
 SAM, IOC and FIFA country code for American Samoa
 Sam, Benin
 Sam, Boulkiemdé, Burkina Faso
 Sam, Bourzanga, Burkina Faso
 Sam, Iran
 Sam, Kongoussi, Burkina Faso
 Sam, Teton County, Idaho, a populated place located in Idaho

People and language
 Sam (given name), a list of people with the given name
 Sam (surname), a list of people with the surname
 Cen (surname) (岑), romanized "Sam" in Cantonese
 Shen (surname) (沈), often romanized "Sam" in Cantonese
 Sam languages, comprising Somali, Rendille and Boni
 Sam language of New Guinea
 Sam (Book of Mormon), elder brother of Nephi
 Sām, a Persian folk hero

Animals
 Sam (army dog) (died 2000)
 Sam (horse) (b 1815), British Thoroughbred
 Sam (koala) (died 2009), rescued after 2009 bush fires in Victoria, Australia
 Sam (orangutan), in the movie Dunston Checks In
 Sam (ugly dog) (1990–2005), voted the world's ugliest dog in 2003, 2004, and 2005
 Unsinkable Sam (died 1955), cat, survived the sinking of 3 ships during WWII

Art, entertainment, and media

 Sam (1967 film), a 1976 film directed by Larry Buchanan
 Sam (1986 film), a 1986 documentary film
 Sam (Osvajači album), 1995
 Sam (Škabo album), 2003
 "Sam" (Olivia Newton-John song), 1977
 Sam (1973 TV series), British drama
 Sam (1978 TV series), US crime drama
 S.A.M. (comics), a French comic book
 SAM Awards, for South Australian Music Awards given by Music SA

Business

Brands and enterprises
 SAM (vehicles), a Greek truck manufacturer
 S.A.M.: Simply About Music, a satellite-driven radio network
 SAM, stock ticker of Boston Beer Company, the brewers of Samuel Adams beer
 SAM Colombia, a Colombian airline
 SAM Records, an American disco/post-disco record company
 Società Aerea Mediterranea, an Italian airline 1926-1934 and 1959-1981

Business terminology
 Serviceable available market
 Shared appreciation mortgage
 Social accounting matrix of transactions in an economy
 System for Award Management (SAM), U.S. Government supplier database

Museums
 Seattle Art Museum
 SAM, museum code for the South Australian Museum

Organizations
 Scientific Advice Mechanism of the European Commission
 Serve America Movement, an American political party
 Snowmobile Association of Massachusetts
 Society of American Magicians

Science and technology

Biology, chemistry and medicine
 Phytelephas seemannii, known in Cuna as ''
 S-Adenosyl methionine, a common co-substrate involved in methyl group transfers
 SAM, a candidate phylum of bacteria
 SAMtools (for Sequence Alignment Map), a data storage format for DNA sequencing 
 Self-assembled monolayer of amphiphilic molecules 
 Shoot apical meristem, a plant tissue
 Significance analysis of microarrays, in DNA microanalysis
 Spore photoproduct lyase, an enzyme
 Sorting and assembly machinery, a protein complex in the outer mitochondrial membrane
 Segmental arterial mediolysis, a medical condition affecting the arteries

Physics and astronomy
 Southern Annular Mode of southern hemisphere atmospheric variability
 Swinging Atwood's machine
 SAm, an unbarred Magellanic spiral galaxy

Software and computing
 SAM (file format) or Sequence Alignment Map, a data format used in bioinformatics.
 SAM (chatbot)
 Sam (text editor)
 Microsoft Sam, a voice for the screen reader in Windows 2000 and XP
 SAM Broadcaster, an Internet radio broadcasting application
 SAM Coupé, an 8-bit British home computer
 SAM Lock Tool, better known as Syskey
 Sequential access memory
 Simple Anonymous Messaging, a protocol specification used in the I2P network layer
 Simulation for Automatic Machinery, two minicomputers
 Software asset management
 Software Automatic Mouth, speech synthesis program
 SAM (Synchronous Address Multiplexer), a chip in some 8-bit computers
 Syriac Abbreviation Mark, a Unicode control character

Security 
 SAM card (Security Authentication Module card), holding cryptographic keys
 Secure access module
 Security Account Manager in Microsoft Windows

Other
 Scanning acoustic microscope
 Sample Analysis at Mars, on the Curiosity rover
 Scanning Auger microscope in Auger electron spectroscopy
 Small article monitor, screening for radioactive contamination
 Sparse antimagic square, in mathematics
 Stop action magnet in a pipe organ
 Surface-to-air missile, an anti-aircraft missile

Sports
 Sam (mascot), 1984 Summer Olympics
 Strongside linebacker, gridiron football nickname

Other uses
 Sandy Area Metro, Oregon, US
 Special administrative measures, in US law
 Uncle Sam, a personification of the US government
 Synodically Authorized Minister, often used in parentheses after an officiator's name

Related pages
 Sam and the Womp, a British band
 Sam FM (disambiguation)
 Samantha, Samhita, Samskruthi, female given names often shortened to "Sam"
 Sammy (disambiguation), an informal variation on the name "Sam"
 Samsø, earlier Samsey, literally "Sam's island"
 Samuel (name)
 Son of Sam