The Simpson family
 Homer J. Simpson, the father, who is overweight, lazy and works at a nuclear power plant and likes doughnuts:)
 Marge Simpson (née Bouvier), the mother, a housewife, who is very tolerant (understanding) of her family.
 Bart Simpson, the 10-year-old son, who gets in trouble.
 Lisa Simpson, the 8-year-old daughter, who is very smart.
 Maggie Simpson, the baby girl, who can not talk. She talks once and never speaks again. She is always doing mischief.
 "Grandpa" Abe Simpson, the father of Homer Simpson. He lives in an old folk's home.
 Patty and Selma Bouvier, Marge's sisters, who have rough voices and often smoke cigarettes. Note that in one episode, Patty is revealed to be a lesbian. Selma has been married several times.
 Mona Simpson, the deceased mother of Homer Simpson; wife of Abe Simpson.
 Santa's Little Helper, the family dog, a former racing greyhound.
 Snowballs (I-V) and Coltrane, pet cats. All have died at one point in the series. The current cat is Snowball V (though she is called Snowball II)
 Ling Bouvier, The adopted daughter of Patty and Selma
 Amos Simpson, He is the oldest Simpsons relative known he is probably born in the 1500s or 1600s.
 Jacqueline Bouvier, Marge's mother.
 Clancy Bouvier, Marge's deceased father.

Other characters 
Some of the many different characters who appeared on the show include:
 Montgomery Burns, Homer's greedy, evil boss
 Waylon Smithers, Montgomery Burns' assistant
 Moe Szyslak, a grumpy bartender
 Barney Gumble, one of Homer's friends, a gifted alcoholic
 Kent Brockman, a television news journalist
 Mayor Quimby, the corrupt mayor of Springfield
 Lenny Leonard and Carl Carlson, two of Homer's coworkers.
 Krusty The Clown, TV star and host of a popular Children's/Comedy/Variety show who smokes and drinks a lot
 Doctor Hibbert, the Simpsons' family doctor
 Ned Flanders, the Simpsons' religious devout neighbor he has two shy children and his wife Maude died in season 11.
 Rod and Todd Flanders, Ned's children.
 Maude, Ned's dead wife.
 Kang and Kodos, two aliens that appear in every treehouse of horror their other sibling roger doesn't appear in any other treehouse of horror except the first
 Milhouse Van Houten, Bart's nerdy best friend his parents are Kirk and Luann
 Sherri and Terri, they’re two twins there's not munch known about them
 Nelson Muntz, school bully
 Comic Book Guy, comic book store owner
 Apu Nahasapeemapetilon, convenience store owner his wife is Manjula he has eight infant children. There have been protests that he is a racist stereotype of South Asian people.
 Martin Prince, he is the bully's target besides Milhouse and he is also very smart.
 Seymour Skinner, principal of the school
 Chief Wiggum, incompetent chief of police who's son is Ralph.
 Ralph Wiggum, the weird son of Chief Wiggum.
 Jasper Beardly, friend of Grandpa's.
 Captain McCallister, sea captain.
 Otto Mann, bus driver.

 Bumblebee Man, Spanish-speaking TV actor.
 Itchy and Scratchy, cartoon cat and mouse who are a different more violent version of Tom and Jerry.
 Jimbo Jones, leader of the bullies when Nelson is not around and strongest of the bullies.
 Snake (Jailbird), robber and criminal.
 Old Gil Gunderson, a salesman who has bad luck.
 Sideshow Bob (Robert Terwilliger), was Krusty the Clown's assistant before he was jailed after framing Krusty for armed robbery.
 He was married to Selma once, has tried to kill Bart several times, and has gone to prison.
 Fat Tony, the town's chief gangster who has a group of mobsters, including Legs and Louie, and occasionally Icepick and Johnny Tightlips. He died in Season 22 and was replaced by his slimmer cousin.
 Sideshow Cecil (Cecil Terwilliger), Sideshow Bob's somewhat evil brother, who was also once a clown.
 Janey, Lisa's best friend.
 Ranier Wolfcastle, The Arnold Schwarzenegger-like Hollywood action hero of Springfield who is in a lot of movies in Springfield.
 Mr. Largo, the Springfield Elementary music teacher.
 Tobias, the stereotypical Australian boy telephoned by Bart in the "Simpson's in Australia" episode.
 Superintendent Chalmers, The superintendent of all Springfield elementary schools who does not like Principal Skinner.
 Agnes Skinner, The mean mother of Principal Skinner.
 Mrs. Krabappel and Ms. Hoover, Bart and Lisa's teachers, who both do not want to teach because they do not have relationships.
 Groundskeeper Willie, janitor at Springfield Elementary School.
 Cletus, the hillbilly of Springfield, has a wife named Brandine and have about 30 children.
 Hans Moleman, a man who drinks and says he's only 31 years old, while he looks old.
 Sideshow Mel, Krusty's second assistant who replaced Bob after going to prison for trying to frame Krusty for armed robbery. He does not say much on the Krusty show (talks with a whistle) and once tried to get gum out of his hair with a bone ....it just made matters worse.
 Dolph Starbeam youngest of the bully trio
 Professor Frink He is the nerd of the show.
 Kearney Zzyzwick Toughest of the bullies.
 Yes Guy Recurring character that answers everything with a strung out Y-y-y-y-e-e-e-e-s-s-s?
 Squeaky Voice Teen, recurring character that has a squeaky voice and is known to have a job advertising burgers.
 Wendell Borton, a kid that usually would throw up.
 Troy McClure, an actor in TV, Radio and films he once almost married Selma.
 Lionel Hutz, an incompetent lawyer.
 Judge Roy Snyder, the main judge in Springfield's court.
 Lou and Eddie, police cops of Springfield.
 Legs and Louie, Mafia members.
 Reverend Lovejoy, reverend of the church.
 Helen Lovejoy, wife of the reverend.
 Uter, German exchange student who eats chocolate.
 Database, smartest of all the children in school.
 Manjula, Apu's wife.
 Kirk and Luann, Milhouse's parents.
 Old Jewish man, one of Abe's friends.
 Allison Taylor, one of Lisa's only friends.
 Arnie Pye, Brockman's rival.
 Blue Haired Lawyer, Burns lawyer.
 Richard and Lewis, one of Bart's friends.
 Marvin Monroe, psychologist.
 Rich Texan, crazy Texan.
 Drederick Tatum, boxer.
 Wiseguy, has jobs everywhere.
 Sanjay, Apu's brother.
 Sam and Larry, barflies at Moe's.
 Bernice, Hibbert's wife.
 Mrs. Glick, Retirement castle resident.
 Disco Stu, loves disco.
 Hyman Krustofski, Krusty's father.
 Lindsey Naegle, business woman.
Sophie Krustofsky, Krusty's daughter.
 Martin Prince Sr., Martin's dad.
 Martha Prince, Martin's mom.
 Brandine Spuckler, Cletus's wife.
 Luigi, Italian chef.
 Radioactive man, Comic book character.
 Duffman, mascot of duff.
 Doris Freedman, Lunchlady and mother of Squeaky Voiced Teen.
 Cookie Kwan, one of Marge's friend.
 Benjamin, Doug and Gary, nerds at Springfield University.
 Akira, Asian guy who works at the Happy Sumo.
 Artie Ziff, Marge's prom date.
 Arthur Crandall and Gabbo, ventriloquist and puppet.
 Gerald, Maggie's enemy.
 Bill and Marty, radio hosts of KBBL.
 Billy, Troy McClure's assistant.
 Birch Barlow, works at the radio.
 Bleeding Gums Murphy, Lisa's saxophone teacher and idol.
 Blinky, mutated fish with three eyes.
 Booberella, vampire actor of children's television.
 Brunella Pommelhorst, gym teacher.
 Capitol City Goofball, mascot of Capitol City.
 Lance Murdock, daredevil.
 Charlie, works at the Nuclear Plant.
 Kumiko, married wife of Comic Book Guy.
 Chase/Pyro, Luann's boyfriend.
 Lugash, gym teacher.
 Corporal Punishment, character in The Krusty The Clown show. H e never speaks.
 Crazy Cat Lady, old lady who owns a lot of cats.
 Crusher and Lowblow, Burn's goons.
 Dave Shutton, reporter.
 Declan Desmond, documentary maker.
 Doctor Colossus, blue, evil, crazy guy.
 Fallout boy, Radioactive man's sidekick.
 Francesca Terwilliger, Sideshow Bob's wife.
 Frankie The Squealer, target of the mafia.
 Gino, Sideshow Bob's son.
 Gloria, Snake's girlfriend.
 God, the all mighty.
 Grady and Julio, two gay men.
 Greta, Wolfcastle's daughter.
 Gunter and Ernst, two tiger tamers.
 Anastasia, tiger pet of Gunter and Ernst.
 Happy Little Elves, one of Lisa's favorite cartoons.
 Jack Marley, former Nuclear Plant worker.
 Jay Sherman, film critic.
 Jebediah Springfield, founder of Springfield.
 Johnny Tightlips, mafia member.
 Joey, another mafia member who temporarily joined the Callibricis goons then appears in the mafia again.
 Jub - Jub, Selma's pet.
 Constance Harm, strict judge.
 Just Stamp the Ticket man, angry and sarcastic man.
 J. Loren Pryor, psychologist.
 Kearney Zzyzwicz Jr., Kearney's son.
 Leopold, Chalmer's assistant.
 Lois Pennycandy, Krusty's attractive assistant.
 Lucius Sweet, Tatum's boxing manager.
 Lurleen Lumpkin, country singer.
 Martha Prince, Mayor's wife.
 Mary Bailey, governor.
 Mary Spuckler, Bart's ex.
 Mayor Quimby's Body Guards, Body Guards.
 Ms. Albright, Sunday school teacher.
 Miss Springfield, Mayor's girlfriend.
 Mr. Costington, owner of Costington's.
 Mr. Teeny, Krusty's monkey.
 Mrs. Muntz, Nelson's mom.
 Octuplets, Apu and Manjula's babies.
 Jake, barber.
 Opal, TV star of the Opal Show.
 Patches and Poor Violet, orphans.
 Plopper, Homer's pet pig.
 Poochie, former dog character in the Itchy and Scratchy Show.
 Princess Kashmir, belly dancer.
 Principal Dondelinger, Homer and Marge's former principal.
 Rachel Jordan, Christian singer.
 Roger Meyers Jr., boss of the Itchy and Scratchy crew.
 Ruth Powers, Marge's criminal and drunken friend.
 Sarah Wiggum, Wiggum's wife.
 Scott Christian, former news reporter.
 Shauna, Jimbo's ex.
 Stampy, Bart's former elephant pet.
 State Comptroller Atkins, State Comptroller.
 Tina Ballerina, character in the Krusty The Clown show.
 The Warden, warden of Juvie.
 Vanderbilts, rich couple.
 Weasels, Nelson two twin cronies.
 Mr. Winfield, former neighbor of The Simpsons.
 Sylvia Winfield, former neighbor of The Simpsons.
 Hank Scorpio, evil guy who befriends Homer.
 Frank Grimes, former employee of the Nuclear Plant
 Frank Grimes Jr., Frank Grime's son.
 Shary Bobbins, Magic babysitter.
 Trent Steel, Business man that inspires Homer to change his name to "Max Power"

Other websites
 Characters index on the WikiSimpsons fan site

Lists of television characters