Context: Document [1](Title: Klaus (The Vampire Diaries)) leaves Elijah to go to Jenna. In a flashback, we see that Elijah was in love with Katherine back in 1492. Elena tries to calm Jenna down and tells her the whole truth. Then, she goes back to Elijah, asking him to tell her about the curse. Elijah tells her that his mother was unfaithful to his father and Klaus is a brother from another father, a werewolf, something that makes Klaus both a vampire and a werewolf. Klaus wants to break the curse that is upon him so he can reawaken his werewolf side and create an army of

Context: Document [2](Title: Klaus (The Vampire Diaries)) hybrids. Since Klaus is both a vampire and a werewolf, Elijah explains Elena that the dagger cannot kill him, and they have to try to do it using a witch when Klaus is on transition, a moment that makes him weak. Elena tells him that she knows a witch that can channel the power they need, and Elijah tells her that the curse needs to be broken during a full moon. Through another flashback, we see that Elijah found a way to protect the life of the doppelgänger during the sacrifice, meaning he can protect Elena's life. Katherine did not

Context: Document [3](Title: Original Vampires (The Vampire Diaries)) they became vampires, can kill Originals. Elijah then works with a witch to locate Elena. The witch is able to locate her, so he goes to Mystic Falls to confront her, where he ends up saving her from a group of vampires who also wanted to take Elena. It is revealed that those vampires wanted to hand her over to Klaus. When Elijah discovers this, he makes peace with Elena and her friends, because he wants to use Elena as bait to draw out Klaus and kill him. He thus makes a deal with Elena that if she helps him

Context: Document [4](Title: The Vampire Diaries (season 3)) premiered on Thursday, September 15, 2011. The series stars Nina Dobrev as Elena Gilbert and Katherine Pierce, Paul Wesley as Stefan Salvatore and Silas, Ian Somerhalder as Damon Salvatore, Steven R. McQueen as Jeremy Gilbert, Kat Graham as Bonnie Bennett, Candice Accola as Caroline Forbes, Zach Roerig as Matt Donovan, Michael Trevino as Tyler Lockwood, Matt Davis as Alaric Saltzman and Joseph Morgan as Klaus. 7th Heaven's David Gallagher was cast as werewolf Ray Sutton who has a run-in with Klaus in Tennessee. Australian actress, Claire Holt has been cast as Rebekah the sister of Klaus and Elijah, a beautiful

Context: Document [5](Title: Original Vampires (The Vampire Diaries)) Elijah is trapped in a room with animal heads which represent each brother of the family. To escape, Elijah discovers you must ruin the representation of each other, thus causing him to share with Klaus that he killed Tatia. When Klaus proves he is capable of forgiveness the spell is broken and they are free. Niklaus Mikaelson (more commonly called Klaus) is physically the most powerful immortal supernatural being in "The Vampire Diaries" and "The Originals" universe. He is shown to be cruel, sadistic, ruthless. He's portrayed by British actor Joseph Morgan. After the Original couple moved to the Americas,

Context: Document [6](Title: Original Vampires (The Vampire Diaries)) not trust Elijah and chose to flee. Later, he would punish her for her betrayal by compelling her to stay in a tomb until he said otherwise. Elena is rescued by the Salvatore brothers not long after Elijah kills Trevor, who had betrayed Elijah in the past by helping Katerina escape. The Salvatores attack Elijah and succeed in staking him; however, he comes back to life at the end of the episode because he is an Original Vampire who can not be killed by any wooden stake. Only wood from the ancient White Oak Tree, which his family burned when

Context: Document [7](Title: Original Vampires (The Vampire Diaries)) leaves Mystic Falls a tortured soul, ashamed of his own barbaric actions and those of his family's. He is shown to be one of the most sophisticated and peaceful of the Original siblings, alongside his older brother Finn. He is the most compromising regarding Elena and her friends. Elijah and Elena develop a sort of understanding, and Elena comes to be fond of Elijah's company. She thus feels especially betrayed when earlier Elijah threatened to allow Rebekah to kill Elena if the Salvatore brothers are not able to stop Esther Mikaelson from killing the Original Family. However, in the 18th

Context: Document [8](Title: The Vampire Diaries (season 3)) an injury. She uses vampire blood to cure people and starts dating Alaric. On November 16, 2011, it was announced that Robert Ri'chard was cast as Jamie a new love interest for resident witch Bonnie. On November 22, 2011, it was announced that Daniel Newman was cast as Daniel Warren, appearing in one episode. Australian actor Nathaniel Buzolic has been cast to play Klaus and Elijah's brother Kol and English actor Caspar Zafer has been cast as their other brother Finn. On January 13, 2012, it was announced that Cassidy Freeman was cast as Sage. On March 31, 2012, Sara

Context: Document [9](Title: Original Vampires (The Vampire Diaries)) kill Klaus, he will leave her family and her friends alone and keep them safe. However, he intends for Elena to be successfully sacrificed, as once Klaus breaks the curse and starts transforming, he will be left vulnerable enough to be killed. During a series of events, Elijah is temporarily "killed" when Elena stabs him with a mystical dagger that can kill an Original when dipped in ash from the White Oak Tree. When Klaus comes to town, Elena un-daggers Elijah because she needs his help, and he then reveals to her his family's history, and the fact that Klaus

Context: Document [10](Title: The Vampire Diaries (season 2)) by The CW for a full 22-episode season on February 16, 2010. The first episode premiered on September 9, 2010, at 8 p.m. ET. The season picks up immediately after the events of the season one finale. All the series regulars returned. Season two focuses on the return of Elena Gilbert's (Nina Dobrev) doppelgänger, Katherine Pierce, the introduction of werewolves, the sun and moon curse, and the arrival of the original vampires. Tyler Lockwood's (Michael Trevino) uncle, Mason Lockwood (Taylor Kinney), arrives in town searching for the moonstone, a family heirloom. Tyler later learns of his family's werewolf curse. Meanwhile,

Context: Document [11](Title: The Vampire Diaries (season 2)) for the moonstone, a family heirloom. Tyler later learns of his family's werewolf curse. Meanwhile, Caroline Forbes (Candice Accola) is killed by Katherine while having Damon Salvatore's (Ian Somerhalder) blood in her system, turning her into a vampire. The arrival of the original vampires, Elijah (Daniel Gillies) and Klaus Mikaelson (Joseph Morgan), also bring about complications. Klaus is a vampire-werewolf hybrid, but his werewolf side had been forced into dormancy by witches, as nature would not stand for such an imbalance in power. Therefore, Klaus arrives in town with plans to break the curse and unleash his werewolf side by

Context: Document [12](Title: The Vampire Diaries (season 2)) curse is on Klaus, who therefore wants to kill her. But Elijah says he has an elixir that can save Elena from dying. Elena believes Elijah, but Damon says that there is another way to save her life and feeds her his blood. Stefan tries to stop him, but he stabs in the chest with the wooden dagger. Elena then cries that she will be a vampire against her will. Maddox kidnaps Tyler and Caroline. Damon frees them and is bitten. Then he goes to Klaus to tell him that he does not have a werewolf and witch, as he

Context: Document [13](Title: Original Vampires (The Vampire Diaries)) episode of season 3, Elena professes that she hopes that her vampire friends are descended from Elijah's bloodline, so that he can be spared. Elijah returns to town in the season three finale episode, "The Departed", in order to make a deal with Elena and her friends. Elijah proposes that he be allowed to take Klaus's desiccated (by witch Bonnie and help from the Salvatores and Tyler) body with him and his siblings and leave town, and in exchange, he would make sure that Klaus would not be resurrected within Elena's lifetime or even that of her children, stating: "perhaps

Context: Document [14](Title: Original Vampires (The Vampire Diaries)) to kill Klaus. When Elijah awakes, he undaggers the rest of his siblings who were located in similar coffins in the same room. They begin to plot their revenge against Klaus; however, before they can make their move, their mother Esther, thought to be dead, reappears and convinces the siblings to be a family again [which later turns out to be a front for her true motives; she wants to link her children's lives together and kill one of them to kill the rest, rendering vampires extinct]. After Elijah foils his mother's plans to kill him and his siblings, he

Context: Document [15](Title: The Vampire Diaries (season 2)) tells her that Klaus will be weakened by the sacrificial ritual, meaning that Elena has to die so that Elijah can kill him and free his sister. John gives Damon the special dagger to kill Elijah. Elena finds out that if a vampire uses the dagger, that vampire will die. Stefan warns Damon and Alaric stabs Elijah, but he pulls the dagger out and tells Elena their deal is off. Elena stabs herself in the stomach, and Elijah begs her to let him heal her. She stabs him with the dagger and leaves it in him. Elijah's death means that

Context: Document [16](Title: The Dinner Party (The Vampire Diaries)) to keep her family and friends safe. Elijah does not seem to agree and Elena threatens to kill herself and become a vampire, just like Katherine did, something the will make her useless for him. Elijah calls her bluff but Elena moves on and stabs herself in the stomach. Elijah freaks out, accepts the deal and asks her to let him heal her. When he gets close enough, Elena stabs him with the dagger and Elijah falls dead. Stefan gives Elena his blood to heal her and Damon is also there reminding to not remove the dagger from the body.

Context: Document [17](Title: The Vampire Diaries (season 3)) daughter has become a monster, but later accepts her. Alice Evans joined the cast as the original witch Esther, Klaus' mother. She was first seen in a flashback in episode eight. Daniel Gillies will also return first appearing in a flashback during episode eight as Klaus' brother, Elijah. Persia White has been cast as Bonnie's mother, Abby Bennett. On November 10, 2011, it was announced that Paul Wesley's wife Torrey DeVitto was cast as Meredith Fell (based off Meredith Sulez from the source novel), a young doctor who is fascinated by Alaric, when she notices how quickly he recovers from

Context: Document [18](Title: All My Children (The Vampire Diaries)) All My Children (The Vampire Diaries) "All My Children" is the fifteenth episode of the third season of The CW television series, "The Vampire Diaries" and the 59th episode of the series overall. It originally aired on February 16, 2012. The episode was written by Evan Bleiweiss & Michael Narducci and directed by Pascal Verschooris. Elijah (Daniel Gillies) finds evidence that Esther (Alice Evans) was casting a spell during the ball and he believes that Elena (Nina Dobrev) lied to him. He kidnaps Elena who tells him that Esther wants to kill them all. Elijah takes Elena into the tunnels

Context: Document [19](Title: The Vampire Diaries (season 5)) Ian Somerhalder as Damon Salvatore; Steven R. McQueen as Jeremy Gilbert; Candice Accola as Caroline Forbes; Zach Roerig as Matt Donovan; Kat Graham as Bonnie Bennett and Michael Trevino as Tyler Lockwood, who is still under contract. Within the first three episodes, four new characters were introduced: Nadia, a girl with a mission of revenge who has traveled around the world, Jesse, an upper-class boy who goes to college, Actors Olga Fonda and Kendrick Sampson were cast in the roles of Nadia and Jesse, respectively. On August 2, 2013, it was announced that Janina Gavankar will play Tessa. The Vampire

Context: Document [20](Title: Crying Wolf (The Vampire Diaries)) for a romantic weekend at her parents' house near the lake. When they get there, Elena remembers her parents and memories of them at the house come back to her mind. Stefan is there for her and they later find out a secret place where Elena's parents were hiding vampire weapons as well as other Gilbert journals. Damon (Ian Somerhalder) meets Elijah (Daniel Gillies) at the tea party Carol (Susan Walters) is organizing and tries to find out his plans and why he wants to keep Elena safe at the moment but Elijah does not seem willing to share his

Question: when does elijah first appear in vampire diaries?

Answer: Rose

Answer: "Rose"

Answer: Season two


Context: Document [1](Title: Klaus (The Vampire Diaries)) leaves Elijah to go to Jenna. In a flashback, we see that Elijah was in love with Katherine back in 1492. Elena tries to calm Jenna down and tells her the whole truth. Then, she goes back to Elijah, asking him to tell her about the curse. Elijah tells her that his mother was unfaithful to his father and Klaus is a brother from another father, a werewolf, something that makes Klaus both a vampire and a werewolf. Klaus wants to break the curse that is upon him so he can reawaken his werewolf side and create an army of

Context: Document [2](Title: Klaus (The Vampire Diaries)) hybrids. Since Klaus is both a vampire and a werewolf, Elijah explains Elena that the dagger cannot kill him, and they have to try to do it using a witch when Klaus is on transition, a moment that makes him weak. Elena tells him that she knows a witch that can channel the power they need, and Elijah tells her that the curse needs to be broken during a full moon. Through another flashback, we see that Elijah found a way to protect the life of the doppelgänger during the sacrifice, meaning he can protect Elena's life. Katherine did not

Context: Document [3](Title: Original Vampires (The Vampire Diaries)) they became vampires, can kill Originals. Elijah then works with a witch to locate Elena. The witch is able to locate her, so he goes to Mystic Falls to confront her, where he ends up saving her from a group of vampires who also wanted to take Elena. It is revealed that those vampires wanted to hand her over to Klaus. When Elijah discovers this, he makes peace with Elena and her friends, because he wants to use Elena as bait to draw out Klaus and kill him. He thus makes a deal with Elena that if she helps him

Context: Document [4](Title: The Vampire Diaries (season 3)) premiered on Thursday, September 15, 2011. The series stars Nina Dobrev as Elena Gilbert and Katherine Pierce, Paul Wesley as Stefan Salvatore and Silas, Ian Somerhalder as Damon Salvatore, Steven R. McQueen as Jeremy Gilbert, Kat Graham as Bonnie Bennett, Candice Accola as Caroline Forbes, Zach Roerig as Matt Donovan, Michael Trevino as Tyler Lockwood, Matt Davis as Alaric Saltzman and Joseph Morgan as Klaus. 7th Heaven's David Gallagher was cast as werewolf Ray Sutton who has a run-in with Klaus in Tennessee. Australian actress, Claire Holt has been cast as Rebekah the sister of Klaus and Elijah, a beautiful

Context: Document [5](Title: Original Vampires (The Vampire Diaries)) Elijah is trapped in a room with animal heads which represent each brother of the family. To escape, Elijah discovers you must ruin the representation of each other, thus causing him to share with Klaus that he killed Tatia. When Klaus proves he is capable of forgiveness the spell is broken and they are free. Niklaus Mikaelson (more commonly called Klaus) is physically the most powerful immortal supernatural being in "The Vampire Diaries" and "The Originals" universe. He is shown to be cruel, sadistic, ruthless. He's portrayed by British actor Joseph Morgan. After the Original couple moved to the Americas,

Context: Document [6](Title: Original Vampires (The Vampire Diaries)) not trust Elijah and chose to flee. Later, he would punish her for her betrayal by compelling her to stay in a tomb until he said otherwise. Elena is rescued by the Salvatore brothers not long after Elijah kills Trevor, who had betrayed Elijah in the past by helping Katerina escape. The Salvatores attack Elijah and succeed in staking him; however, he comes back to life at the end of the episode because he is an Original Vampire who can not be killed by any wooden stake. Only wood from the ancient White Oak Tree, which his family burned when

Context: Document [7](Title: Original Vampires (The Vampire Diaries)) leaves Mystic Falls a tortured soul, ashamed of his own barbaric actions and those of his family's. He is shown to be one of the most sophisticated and peaceful of the Original siblings, alongside his older brother Finn. He is the most compromising regarding Elena and her friends. Elijah and Elena develop a sort of understanding, and Elena comes to be fond of Elijah's company. She thus feels especially betrayed when earlier Elijah threatened to allow Rebekah to kill Elena if the Salvatore brothers are not able to stop Esther Mikaelson from killing the Original Family. However, in the 18th

Context: Document [8](Title: The Vampire Diaries (season 3)) an injury. She uses vampire blood to cure people and starts dating Alaric. On November 16, 2011, it was announced that Robert Ri'chard was cast as Jamie a new love interest for resident witch Bonnie. On November 22, 2011, it was announced that Daniel Newman was cast as Daniel Warren, appearing in one episode. Australian actor Nathaniel Buzolic has been cast to play Klaus and Elijah's brother Kol and English actor Caspar Zafer has been cast as their other brother Finn. On January 13, 2012, it was announced that Cassidy Freeman was cast as Sage. On March 31, 2012, Sara

Context: Document [9](Title: Original Vampires (The Vampire Diaries)) kill Klaus, he will leave her family and her friends alone and keep them safe. However, he intends for Elena to be successfully sacrificed, as once Klaus breaks the curse and starts transforming, he will be left vulnerable enough to be killed. During a series of events, Elijah is temporarily "killed" when Elena stabs him with a mystical dagger that can kill an Original when dipped in ash from the White Oak Tree. When Klaus comes to town, Elena un-daggers Elijah because she needs his help, and he then reveals to her his family's history, and the fact that Klaus

Context: Document [10](Title: The Vampire Diaries (season 2)) for the moonstone, a family heirloom. Tyler later learns of his family's werewolf curse. Meanwhile, Caroline Forbes (Candice Accola) is killed by Katherine while having Damon Salvatore's (Ian Somerhalder) blood in her system, turning her into a vampire. The arrival of the original vampires, Elijah (Daniel Gillies) and Klaus Mikaelson (Joseph Morgan), also bring about complications. Klaus is a vampire-werewolf hybrid, but his werewolf side had been forced into dormancy by witches, as nature would not stand for such an imbalance in power. Therefore, Klaus arrives in town with plans to break the curse and unleash his werewolf side by

Context: Document [11](Title: The Vampire Diaries (season 2)) curse is on Klaus, who therefore wants to kill her. But Elijah says he has an elixir that can save Elena from dying. Elena believes Elijah, but Damon says that there is another way to save her life and feeds her his blood. Stefan tries to stop him, but he stabs in the chest with the wooden dagger. Elena then cries that she will be a vampire against her will. Maddox kidnaps Tyler and Caroline. Damon frees them and is bitten. Then he goes to Klaus to tell him that he does not have a werewolf and witch, as he

Context: Document [12](Title: Original Vampires (The Vampire Diaries)) episode of season 3, Elena professes that she hopes that her vampire friends are descended from Elijah's bloodline, so that he can be spared. Elijah returns to town in the season three finale episode, "The Departed", in order to make a deal with Elena and her friends. Elijah proposes that he be allowed to take Klaus's desiccated (by witch Bonnie and help from the Salvatores and Tyler) body with him and his siblings and leave town, and in exchange, he would make sure that Klaus would not be resurrected within Elena's lifetime or even that of her children, stating: "perhaps

Context: Document [13](Title: Original Vampires (The Vampire Diaries)) to kill Klaus. When Elijah awakes, he undaggers the rest of his siblings who were located in similar coffins in the same room. They begin to plot their revenge against Klaus; however, before they can make their move, their mother Esther, thought to be dead, reappears and convinces the siblings to be a family again [which later turns out to be a front for her true motives; she wants to link her children's lives together and kill one of them to kill the rest, rendering vampires extinct]. After Elijah foils his mother's plans to kill him and his siblings, he

Context: Document [14](Title: The Vampire Diaries (season 2)) tells her that Klaus will be weakened by the sacrificial ritual, meaning that Elena has to die so that Elijah can kill him and free his sister. John gives Damon the special dagger to kill Elijah. Elena finds out that if a vampire uses the dagger, that vampire will die. Stefan warns Damon and Alaric stabs Elijah, but he pulls the dagger out and tells Elena their deal is off. Elena stabs herself in the stomach, and Elijah begs her to let him heal her. She stabs him with the dagger and leaves it in him. Elijah's death means that

Context: Document [15](Title: The Vampire Diaries (season 2)) by The CW for a full 22-episode season on February 16, 2010. The first episode premiered on September 9, 2010, at 8 p.m. ET. The season picks up immediately after the events of the season one finale. All the series regulars returned. Season two focuses on the return of Elena Gilbert's (Nina Dobrev) doppelgänger, Katherine Pierce, the introduction of werewolves, the sun and moon curse, and the arrival of the original vampires. Tyler Lockwood's (Michael Trevino) uncle, Mason Lockwood (Taylor Kinney), arrives in town searching for the moonstone, a family heirloom. Tyler later learns of his family's werewolf curse. Meanwhile,

Context: Document [16](Title: The Dinner Party (The Vampire Diaries)) to keep her family and friends safe. Elijah does not seem to agree and Elena threatens to kill herself and become a vampire, just like Katherine did, something the will make her useless for him. Elijah calls her bluff but Elena moves on and stabs herself in the stomach. Elijah freaks out, accepts the deal and asks her to let him heal her. When he gets close enough, Elena stabs him with the dagger and Elijah falls dead. Stefan gives Elena his blood to heal her and Damon is also there reminding to not remove the dagger from the body.

Context: Document [17](Title: The Vampire Diaries (season 3)) daughter has become a monster, but later accepts her. Alice Evans joined the cast as the original witch Esther, Klaus' mother. She was first seen in a flashback in episode eight. Daniel Gillies will also return first appearing in a flashback during episode eight as Klaus' brother, Elijah. Persia White has been cast as Bonnie's mother, Abby Bennett. On November 10, 2011, it was announced that Paul Wesley's wife Torrey DeVitto was cast as Meredith Fell (based off Meredith Sulez from the source novel), a young doctor who is fascinated by Alaric, when she notices how quickly he recovers from

Context: Document [18](Title: All My Children (The Vampire Diaries)) All My Children (The Vampire Diaries) "All My Children" is the fifteenth episode of the third season of The CW television series, "The Vampire Diaries" and the 59th episode of the series overall. It originally aired on February 16, 2012. The episode was written by Evan Bleiweiss & Michael Narducci and directed by Pascal Verschooris. Elijah (Daniel Gillies) finds evidence that Esther (Alice Evans) was casting a spell during the ball and he believes that Elena (Nina Dobrev) lied to him. He kidnaps Elena who tells him that Esther wants to kill them all. Elijah takes Elena into the tunnels

Context: Document [19](Title: The Vampire Diaries (season 5)) Ian Somerhalder as Damon Salvatore; Steven R. McQueen as Jeremy Gilbert; Candice Accola as Caroline Forbes; Zach Roerig as Matt Donovan; Kat Graham as Bonnie Bennett and Michael Trevino as Tyler Lockwood, who is still under contract. Within the first three episodes, four new characters were introduced: Nadia, a girl with a mission of revenge who has traveled around the world, Jesse, an upper-class boy who goes to college, Actors Olga Fonda and Kendrick Sampson were cast in the roles of Nadia and Jesse, respectively. On August 2, 2013, it was announced that Janina Gavankar will play Tessa. The Vampire

Context: Document [20](Title: Crying Wolf (The Vampire Diaries)) for a romantic weekend at her parents' house near the lake. When they get there, Elena remembers her parents and memories of them at the house come back to her mind. Stefan is there for her and they later find out a secret place where Elena's parents were hiding vampire weapons as well as other Gilbert journals. Damon (Ian Somerhalder) meets Elijah (Daniel Gillies) at the tea party Carol (Susan Walters) is organizing and tries to find out his plans and why he wants to keep Elena safe at the moment but Elijah does not seem willing to share his

Question: when does elijah first appear in vampire diaries?

Answer: Rose

Answer: "Rose"

Answer: Season two


Context: Document [1](Title: Klaus (The Vampire Diaries)) leaves Elijah to go to Jenna. In a flashback, we see that Elijah was in love with Katherine back in 1492. Elena tries to calm Jenna down and tells her the whole truth. Then, she goes back to Elijah, asking him to tell her about the curse. Elijah tells her that his mother was unfaithful to his father and Klaus is a brother from another father, a werewolf, something that makes Klaus both a vampire and a werewolf. Klaus wants to break the curse that is upon him so he can reawaken his werewolf side and create an army of

Context: Document [2](Title: Klaus (The Vampire Diaries)) hybrids. Since Klaus is both a vampire and a werewolf, Elijah explains Elena that the dagger cannot kill him, and they have to try to do it using a witch when Klaus is on transition, a moment that makes him weak. Elena tells him that she knows a witch that can channel the power they need, and Elijah tells her that the curse needs to be broken during a full moon. Through another flashback, we see that Elijah found a way to protect the life of the doppelgänger during the sacrifice, meaning he can protect Elena's life. Katherine did not

Context: Document [3](Title: Original Vampires (The Vampire Diaries)) they became vampires, can kill Originals. Elijah then works with a witch to locate Elena. The witch is able to locate her, so he goes to Mystic Falls to confront her, where he ends up saving her from a group of vampires who also wanted to take Elena. It is revealed that those vampires wanted to hand her over to Klaus. When Elijah discovers this, he makes peace with Elena and her friends, because he wants to use Elena as bait to draw out Klaus and kill him. He thus makes a deal with Elena that if she helps him

Context: Document [4](Title: The Vampire Diaries (season 3)) premiered on Thursday, September 15, 2011. The series stars Nina Dobrev as Elena Gilbert and Katherine Pierce, Paul Wesley as Stefan Salvatore and Silas, Ian Somerhalder as Damon Salvatore, Steven R. McQueen as Jeremy Gilbert, Kat Graham as Bonnie Bennett, Candice Accola as Caroline Forbes, Zach Roerig as Matt Donovan, Michael Trevino as Tyler Lockwood, Matt Davis as Alaric Saltzman and Joseph Morgan as Klaus. 7th Heaven's David Gallagher was cast as werewolf Ray Sutton who has a run-in with Klaus in Tennessee. Australian actress, Claire Holt has been cast as Rebekah the sister of Klaus and Elijah, a beautiful

Context: Document [5](Title: Original Vampires (The Vampire Diaries)) Elijah is trapped in a room with animal heads which represent each brother of the family. To escape, Elijah discovers you must ruin the representation of each other, thus causing him to share with Klaus that he killed Tatia. When Klaus proves he is capable of forgiveness the spell is broken and they are free. Niklaus Mikaelson (more commonly called Klaus) is physically the most powerful immortal supernatural being in "The Vampire Diaries" and "The Originals" universe. He is shown to be cruel, sadistic, ruthless. He's portrayed by British actor Joseph Morgan. After the Original couple moved to the Americas,

Context: Document [6](Title: Original Vampires (The Vampire Diaries)) not trust Elijah and chose to flee. Later, he would punish her for her betrayal by compelling her to stay in a tomb until he said otherwise. Elena is rescued by the Salvatore brothers not long after Elijah kills Trevor, who had betrayed Elijah in the past by helping Katerina escape. The Salvatores attack Elijah and succeed in staking him; however, he comes back to life at the end of the episode because he is an Original Vampire who can not be killed by any wooden stake. Only wood from the ancient White Oak Tree, which his family burned when

Context: Document [7](Title: Original Vampires (The Vampire Diaries)) leaves Mystic Falls a tortured soul, ashamed of his own barbaric actions and those of his family's. He is shown to be one of the most sophisticated and peaceful of the Original siblings, alongside his older brother Finn. He is the most compromising regarding Elena and her friends. Elijah and Elena develop a sort of understanding, and Elena comes to be fond of Elijah's company. She thus feels especially betrayed when earlier Elijah threatened to allow Rebekah to kill Elena if the Salvatore brothers are not able to stop Esther Mikaelson from killing the Original Family. However, in the 18th

Context: Document [8](Title: The Vampire Diaries (season 3)) an injury. She uses vampire blood to cure people and starts dating Alaric. On November 16, 2011, it was announced that Robert Ri'chard was cast as Jamie a new love interest for resident witch Bonnie. On November 22, 2011, it was announced that Daniel Newman was cast as Daniel Warren, appearing in one episode. Australian actor Nathaniel Buzolic has been cast to play Klaus and Elijah's brother Kol and English actor Caspar Zafer has been cast as their other brother Finn. On January 13, 2012, it was announced that Cassidy Freeman was cast as Sage. On March 31, 2012, Sara

Context: Document [9](Title: Original Vampires (The Vampire Diaries)) kill Klaus, he will leave her family and her friends alone and keep them safe. However, he intends for Elena to be successfully sacrificed, as once Klaus breaks the curse and starts transforming, he will be left vulnerable enough to be killed. During a series of events, Elijah is temporarily "killed" when Elena stabs him with a mystical dagger that can kill an Original when dipped in ash from the White Oak Tree. When Klaus comes to town, Elena un-daggers Elijah because she needs his help, and he then reveals to her his family's history, and the fact that Klaus

Context: Document [10](Title: The Vampire Diaries (season 2)) for the moonstone, a family heirloom. Tyler later learns of his family's werewolf curse. Meanwhile, Caroline Forbes (Candice Accola) is killed by Katherine while having Damon Salvatore's (Ian Somerhalder) blood in her system, turning her into a vampire. The arrival of the original vampires, Elijah (Daniel Gillies) and Klaus Mikaelson (Joseph Morgan), also bring about complications. Klaus is a vampire-werewolf hybrid, but his werewolf side had been forced into dormancy by witches, as nature would not stand for such an imbalance in power. Therefore, Klaus arrives in town with plans to break the curse and unleash his werewolf side by

Context: Document [11](Title: The Vampire Diaries (season 2)) curse is on Klaus, who therefore wants to kill her. But Elijah says he has an elixir that can save Elena from dying. Elena believes Elijah, but Damon says that there is another way to save her life and feeds her his blood. Stefan tries to stop him, but he stabs in the chest with the wooden dagger. Elena then cries that she will be a vampire against her will. Maddox kidnaps Tyler and Caroline. Damon frees them and is bitten. Then he goes to Klaus to tell him that he does not have a werewolf and witch, as he

Context: Document [12](Title: Original Vampires (The Vampire Diaries)) episode of season 3, Elena professes that she hopes that her vampire friends are descended from Elijah's bloodline, so that he can be spared. Elijah returns to town in the season three finale episode, "The Departed", in order to make a deal with Elena and her friends. Elijah proposes that he be allowed to take Klaus's desiccated (by witch Bonnie and help from the Salvatores and Tyler) body with him and his siblings and leave town, and in exchange, he would make sure that Klaus would not be resurrected within Elena's lifetime or even that of her children, stating: "perhaps

Context: Document [13](Title: Original Vampires (The Vampire Diaries)) to kill Klaus. When Elijah awakes, he undaggers the rest of his siblings who were located in similar coffins in the same room. They begin to plot their revenge against Klaus; however, before they can make their move, their mother Esther, thought to be dead, reappears and convinces the siblings to be a family again [which later turns out to be a front for her true motives; she wants to link her children's lives together and kill one of them to kill the rest, rendering vampires extinct]. After Elijah foils his mother's plans to kill him and his siblings, he

Context: Document [14](Title: The Vampire Diaries (season 2)) tells her that Klaus will be weakened by the sacrificial ritual, meaning that Elena has to die so that Elijah can kill him and free his sister. John gives Damon the special dagger to kill Elijah. Elena finds out that if a vampire uses the dagger, that vampire will die. Stefan warns Damon and Alaric stabs Elijah, but he pulls the dagger out and tells Elena their deal is off. Elena stabs herself in the stomach, and Elijah begs her to let him heal her. She stabs him with the dagger and leaves it in him. Elijah's death means that

Context: Document [15](Title: The Dinner Party (The Vampire Diaries)) to keep her family and friends safe. Elijah does not seem to agree and Elena threatens to kill herself and become a vampire, just like Katherine did, something the will make her useless for him. Elijah calls her bluff but Elena moves on and stabs herself in the stomach. Elijah freaks out, accepts the deal and asks her to let him heal her. When he gets close enough, Elena stabs him with the dagger and Elijah falls dead. Stefan gives Elena his blood to heal her and Damon is also there reminding to not remove the dagger from the body.

Context: Document [16](Title: The Vampire Diaries (season 3)) daughter has become a monster, but later accepts her. Alice Evans joined the cast as the original witch Esther, Klaus' mother. She was first seen in a flashback in episode eight. Daniel Gillies will also return first appearing in a flashback during episode eight as Klaus' brother, Elijah. Persia White has been cast as Bonnie's mother, Abby Bennett. On November 10, 2011, it was announced that Paul Wesley's wife Torrey DeVitto was cast as Meredith Fell (based off Meredith Sulez from the source novel), a young doctor who is fascinated by Alaric, when she notices how quickly he recovers from

Context: Document [17](Title: All My Children (The Vampire Diaries)) All My Children (The Vampire Diaries) "All My Children" is the fifteenth episode of the third season of The CW television series, "The Vampire Diaries" and the 59th episode of the series overall. It originally aired on February 16, 2012. The episode was written by Evan Bleiweiss & Michael Narducci and directed by Pascal Verschooris. Elijah (Daniel Gillies) finds evidence that Esther (Alice Evans) was casting a spell during the ball and he believes that Elena (Nina Dobrev) lied to him. He kidnaps Elena who tells him that Esther wants to kill them all. Elijah takes Elena into the tunnels

Context: Document [18](Title: The Vampire Diaries (season 5)) Ian Somerhalder as Damon Salvatore; Steven R. McQueen as Jeremy Gilbert; Candice Accola as Caroline Forbes; Zach Roerig as Matt Donovan; Kat Graham as Bonnie Bennett and Michael Trevino as Tyler Lockwood, who is still under contract. Within the first three episodes, four new characters were introduced: Nadia, a girl with a mission of revenge who has traveled around the world, Jesse, an upper-class boy who goes to college, Actors Olga Fonda and Kendrick Sampson were cast in the roles of Nadia and Jesse, respectively. On August 2, 2013, it was announced that Janina Gavankar will play Tessa. The Vampire

Context: Document [19](Title: Crying Wolf (The Vampire Diaries)) for a romantic weekend at her parents' house near the lake. When they get there, Elena remembers her parents and memories of them at the house come back to her mind. Stefan is there for her and they later find out a secret place where Elena's parents were hiding vampire weapons as well as other Gilbert journals. Damon (Ian Somerhalder) meets Elijah (Daniel Gillies) at the tea party Carol (Susan Walters) is organizing and tries to find out his plans and why he wants to keep Elena safe at the moment but Elijah does not seem willing to share his

Context: Document [20](Title: The Vampire Diaries (season 2)) by The CW for a full 22-episode season on February 16, 2010. The first episode premiered on September 9, 2010, at 8 p.m. ET. The season picks up immediately after the events of the season one finale. All the series regulars returned. Season two focuses on the return of Elena Gilbert's (Nina Dobrev) doppelgänger, Katherine Pierce, the introduction of werewolves, the sun and moon curse, and the arrival of the original vampires. Tyler Lockwood's (Michael Trevino) uncle, Mason Lockwood (Taylor Kinney), arrives in town searching for the moonstone, a family heirloom. Tyler later learns of his family's werewolf curse. Meanwhile,

Question: when does elijah first appear in vampire diaries?

Answer: Rose

Answer: "Rose"

Answer: Season two


Context: Document [1](Title: Retina) In section, the retina is no more than 0.5 mm thick. It has three layers of nerve cells and two of synapses, including the unique ribbon synapse. The optic nerve carries the ganglion cell axons to the brain, and the blood vessels that supply the retina. The ganglion cells lie innermost in the eye while the photoreceptive cells lie beyond. Because of this counter-intuitive arrangement, light must first pass through and around the ganglion cells and through the thickness of the retina, (including its capillary vessels, not shown) before reaching the rods and cones. Light is absorbed by the retinal

Context: Document [2](Title: Retina) is "wired wrongly" or "badly designed"; but in fact, the retina could not function if it were not inverted. The photoreceptor layer must be embedded in the retinal pigment epithelium (RPE), which performs at least seven vital functions, one of the most obvious being to supply oxygen and other necessary nutrients needed for the photoreceptors to function. These nutrients include glucose, fatty acids, and retinal. The mammalian photoreceptor amplification process uses large quantities energy for vision in photopic conditions (requiring less under scotopic conditions) and, thus, requires the large supply nutrients supplied by the blood vessels in the choroid, which

Context: Document [3](Title: Retina) of the forkhead transcription factors FOXD1 and FOXG1. Additional gradients are formed within the retina that aid in proper targeting of RGC axons that function to establish the retinotopic map. The retina is stratified into distinct layers, each containing specific cell types or cellular compartments that have metabolisms with different nutritional requirements. To satisfy these requirements, the ophthalmic artery bifurcates and supplies the retina via two distinct vascular networks: the choroidal network, which supplies the choroid and the outer retina, and the retinal network, which supplies the retina's inner layer. At first glance, one may think that the vertebrate retina

Context: Document [4](Title: Retina) lies beyond the RPE. The choroid supplies about 75% of these nutrients to the retina and the retinal vasculature only 25%. When light strikes 11-cis-retinal (in the disks in the rods and cones), 11-cis-retinal changes to all-trans-retinal which then triggers changes in the opsins. Now, the outer segments do not regenerate the retinal back into the cis- form once it has been changed by light. Instead the retinal is pumped out to the surrounding RPE where it is regenerated and transported back into the outer segments of the photoreceptors. This recycling function of the RPE protects the photoreceptors against photo-oxidative

Context: Document [5](Title: Conjunctiva) Conjunctiva The conjunctiva lines the inside of the eyelids and covers the sclera (the white of the eye). It is composed of non-keratinized, stratified squamous epithelium with goblet cells, and also stratified columnar epithelium. The conjunctiva is highly vascularised, with many microvessels easily accessible for imaging studies. The conjunctiva is typically divided into three parts: Blood to the bulbar conjunctiva is primarily derived from the ophthalmic artery. The blood supply to the palpebral conjunctiva (the eyelid) is derived from the external carotid artery. However, the circulation of the bulbar conjunctiva and palpebral conjunctiva are linked, so both bulbar conjunctival and

Context: Document [6](Title: Eye) pigment epithelium, and constitutes the cells of the dilator muscle. The vitreous is the transparent, colourless, gelatinous mass that fills the space between the lens of the eye and the retina lining the back of the eye. It is produced by certain retinal cells. It is of rather similar composition to the cornea, but contains very few cells (mostly phagocytes which remove unwanted cellular debris in the visual field, as well as the hyalocytes of Balazs of the surface of the vitreous, which reprocess the hyaluronic acid), no blood vessels, and 98–99% of its volume is water (as opposed to

Context: Document [7](Title: Retina) Retina The retina is the innermost, light-sensitive layer, or "coat", of shell tissue of the eye of most vertebrates and some molluscs. The optics of the eye create a focused two-dimensional image of the visual world on the retina, which translates that image into electrical neural impulses to the brain to create visual perception, the retina serving much the same function as film or a CCD in a camera. The retina consists of several layers of neurons interconnected by synapses. The neural retina refers to the three layers of neural cells (photo receptor cells, bipolar cells, and ganglion cells) within

Context: Document [8](Title: Retinylidene protein) of retinal at the ground state that photoisomerizes to an all-"trans" retinal upon light activation. They are commonly found in the light-sensing organs, for example in the photoreceptor cells of vertebrate retina where they facilitate eyesight. Animal opsins can also be found in the skin of amphibians, the pineal glands of lizards and birds, the hypothalamus of toads, and the human brain. They can be categorized into several distinct classes including: The "visual purple" rhodopsin (opsin-2) of the rod cells in the vertebrate retina absorbs green-blue light. The photopsins of the cone cells of the retina differ in a few

Context: Document [9](Title: Sclera) pass. The thickness of the sclera varies from 1mm at the posterior pole to 0.3 mm just behind the rectus muscle insertions. The sclera's blood vessels are mainly on the surface. Along with the vessels of the conjunctiva (which is a thin layer covering the sclera), those in the episclera render the inflamed eye bright red. In many vertebrates, the sclera is reinforced with plates of cartilage or bone, together forming a circular structure called the sclerotic ring. In primitive fish, this ring consists of four plates, but the number is lower in many living ray-finned fishes, and much higher

Context: Document [10](Title: Retinal haemorrhage) Retinal haemorrhage Retinal haemorrhage is a disorder of the eye in which bleeding occurs in the retina, the light sensitive tissue, located on the back wall of the eye. There are photoreceptor cells in the retina called rods and cones, which transduce light energy into nerve signals that can be processed by the brain to form visual images. Retinal hemorrhage can affect adults, and newborn babies and infants may also suffer from this disorder. A retinal hemorrhage can be caused by several medical conditions such as hypertension, retinal vein occlusion (a blockage of a retinal vein), anemia, leukemia or diabetes

Context: Document [11](Title: Retinopathy) blood to sludge, or thicken and flow slowly, through the retinal arteries. Other disorders that cause hyperviscosity syndrome may also cause blood sludging. Lastly, clots or central artery thrombosis directly blocks flow to the retina causing the cells to die. Proliferative retinopathy is the result of aberrant blood flow to the retina due to blood vessel overgrowth, or neovascularization. These pathologically overgrown blood vessels are often fragile, weak, and ineffective at perfusing the retinal tissues. These weak, fragile vessels are also often leaky, allowing fluids, protein, and other debris to leech out into the retina. They are also prone to

Context: Document [12](Title: Retina) entire retina contains about 7 million cones and 75 to 150 million rods. The optic disc, a part of the retina sometimes called "the blind spot" because it lacks photoreceptors, is located at the optic papilla, where the optic-nerve fibres leave the eye. It appears as an oval white area of 3 mm². Temporal (in the direction of the temples) to this disc is the macula, at whose centre is the fovea, a pit that is responsible for our sharp central vision but is actually less sensitive to light because of its lack of rods. Human and non-human primates possess

Context: Document [13](Title: Diabetic retinopathy) show areas of retinal thickening due to fluid accumulation from macular edema. In the second stage, abnormal new blood vessels (neovascularisation) form at the back of the eye as part of "proliferative diabetic retinopathy" (PDR); these can burst and bleed (vitreous hemorrhage) and blur the vision, because these new blood vessels are fragile. The first time this bleeding occurs, it may not be very severe. In most cases, it will leave just a few specks of blood, or spots floating in a person's visual field, though the spots often go away after a few hours. These spots are often followed

Context: Document [14](Title: Epiretinal membrane) field dependent aniseikonia that cannot be fully corrected optically with glasses. Partial correction often improves the binocular vision considerably though. In the young (under 50 years of age), these cells occasionally pull free and disintegrate on their own; but in the majority of sufferers (over 60 years of age) the condition is permanent. The underlying photoreceptor cells, rod cells and cone cells, are usually not damaged unless the membrane becomes quite thick and hard; so usually there is no macular degeneration. The source of the cells in epiretinal membranes (ERM) has been found to comprise glial cells, retinal pigment epithelial

Context: Document [15](Title: Special senses) light from its surroundings onto a light-sensitive membrane in the back of the eye, called the retina. The retina is actually part of the brain that is isolated to serve as a transducer for the conversion of light into neuronal signals. Based on feedback from the visual system, the lens of the eye adjusts its thickness to focus light on the photoreceptive cells of the retina, also known as the rods and cones, which detect the photons of light and respond by producing neural impulses. These signals are processed via complex feedforward and feedback processes by different parts of the

Context: Document [16](Title: Conjunctiva) palpebral conjunctival vessels will be supplied by both the ophthalmic artery and the external carotid artery, to varying extents. Sensory innervation of the conjunctiva is divided into four parts: The conjunctiva consists of non-keratinized, both stratified squamous and stratified columnar epithelium, with interspersed goblet cells. The epithelial layer contains blood vessels, fibrous tissue, and lymphatic channels. Accessory lacrimal glands in the conjunctiva constantly produce the aqueous portion of tears. Additional cells present in the conjunctival epithelium include melanocytes, T and B cell lymphocytes. The conjunctiva helps lubricate the eye by producing mucus and tears, although a smaller volume of tears

Context: Document [17](Title: Rubeosis iridis) VEGF. These factors stimulate the formation of new blood vessels (angiogenesis). Unfortunately, these new vessels do not have the same characteristics as the blood vessels originally formed in the eye. In addition, new blood vessels can form in areas that do not have them. Specifically, new blood vessels can be observed on the iris. In addition to the blood vessels in the iris, they can grow into the angle of the eye. These blood vessels eventually go through a process called fibrosis which closes the normal physiologic anatomy of the angle. The closing of the angle prevents fluid from leaving

Context: Document [18](Title: Retinol) (three forms/colors in humans), responsible for color vision and sensing relatively high light intensities (day vision), are less impaired at early stages of the vitamin A deficiency. All these protein-pigment complexes are located in the light-sensing cells in eye's retina. When stimulated by light, rhodopsin splits into a protein and a cofactor: opsin and all-"trans"-retinal (a form of vitamin A). The regeneration of active rhodopsin requires opsin and 11-"cis"-retinal. The regeneration of 11-"cis"-retinal occurs in vertebrates via a sequence of chemical transformations that constitute "the visual cycle" and which occurs primarily in the retinal pigmented epithelial cells. Without adequate amounts

Context: Document [19](Title: Blood–retinal barrier) Blood–retinal barrier The blood–retinal barrier, or the BRB, is part of the blood–ocular barrier that consists of cells that are joined tightly together to prevent certain substances from entering the tissue of the retina. It consists of non-fenestrated capillaries of the retinal circulation and tight-junctions between retinal epithelial cells preventing passage of large molecules from choriocapillaris into the retina. The blood retinal barrier has two components: the retinal vascular endothelium and the retinal pigment epithelium. Retinal blood vessels that are similar to cerebral blood vessels maintain the inner blood-ocular barrier. This physiological barrier comprises a single layer of non-fenestrated endothelial

Context: Document [20](Title: Optics and vision) called the retina. The retina converts patterns of light into neuronal signals. The lens of the eye focuses light on the photoreceptive cells of the retina, which detect the photons of light and respond by producing neural impulses. These signals are processed in a hierarchical fashion by different parts of the brain, from the retina to the lateral geniculate nucleus, to the primary and secondary visual cortex of the brain. Signals from the retina can also travel directly from the retina to the Superior colliculus. The human eye is an organ which reacts to light for several purposes. As a

Question: where do the blood vessels that supply the retinal cells lie?

Answer: optic nerve

Answer: The optic nerve


Context: Document [1](Title: Retina) is "wired wrongly" or "badly designed"; but in fact, the retina could not function if it were not inverted. The photoreceptor layer must be embedded in the retinal pigment epithelium (RPE), which performs at least seven vital functions, one of the most obvious being to supply oxygen and other necessary nutrients needed for the photoreceptors to function. These nutrients include glucose, fatty acids, and retinal. The mammalian photoreceptor amplification process uses large quantities energy for vision in photopic conditions (requiring less under scotopic conditions) and, thus, requires the large supply nutrients supplied by the blood vessels in the choroid, which

Context: Document [2](Title: Retina) of the forkhead transcription factors FOXD1 and FOXG1. Additional gradients are formed within the retina that aid in proper targeting of RGC axons that function to establish the retinotopic map. The retina is stratified into distinct layers, each containing specific cell types or cellular compartments that have metabolisms with different nutritional requirements. To satisfy these requirements, the ophthalmic artery bifurcates and supplies the retina via two distinct vascular networks: the choroidal network, which supplies the choroid and the outer retina, and the retinal network, which supplies the retina's inner layer. At first glance, one may think that the vertebrate retina

Context: Document [3](Title: Retina) lies beyond the RPE. The choroid supplies about 75% of these nutrients to the retina and the retinal vasculature only 25%. When light strikes 11-cis-retinal (in the disks in the rods and cones), 11-cis-retinal changes to all-trans-retinal which then triggers changes in the opsins. Now, the outer segments do not regenerate the retinal back into the cis- form once it has been changed by light. Instead the retinal is pumped out to the surrounding RPE where it is regenerated and transported back into the outer segments of the photoreceptors. This recycling function of the RPE protects the photoreceptors against photo-oxidative

Context: Document [4](Title: Conjunctiva) Conjunctiva The conjunctiva lines the inside of the eyelids and covers the sclera (the white of the eye). It is composed of non-keratinized, stratified squamous epithelium with goblet cells, and also stratified columnar epithelium. The conjunctiva is highly vascularised, with many microvessels easily accessible for imaging studies. The conjunctiva is typically divided into three parts: Blood to the bulbar conjunctiva is primarily derived from the ophthalmic artery. The blood supply to the palpebral conjunctiva (the eyelid) is derived from the external carotid artery. However, the circulation of the bulbar conjunctiva and palpebral conjunctiva are linked, so both bulbar conjunctival and

Context: Document [5](Title: Retina) In section, the retina is no more than 0.5 mm thick. It has three layers of nerve cells and two of synapses, including the unique ribbon synapse. The optic nerve carries the ganglion cell axons to the brain, and the blood vessels that supply the retina. The ganglion cells lie innermost in the eye while the photoreceptive cells lie beyond. Because of this counter-intuitive arrangement, light must first pass through and around the ganglion cells and through the thickness of the retina, (including its capillary vessels, not shown) before reaching the rods and cones. Light is absorbed by the retinal

Context: Document [6](Title: Eye) pigment epithelium, and constitutes the cells of the dilator muscle. The vitreous is the transparent, colourless, gelatinous mass that fills the space between the lens of the eye and the retina lining the back of the eye. It is produced by certain retinal cells. It is of rather similar composition to the cornea, but contains very few cells (mostly phagocytes which remove unwanted cellular debris in the visual field, as well as the hyalocytes of Balazs of the surface of the vitreous, which reprocess the hyaluronic acid), no blood vessels, and 98–99% of its volume is water (as opposed to

Context: Document [7](Title: Retina) Retina The retina is the innermost, light-sensitive layer, or "coat", of shell tissue of the eye of most vertebrates and some molluscs. The optics of the eye create a focused two-dimensional image of the visual world on the retina, which translates that image into electrical neural impulses to the brain to create visual perception, the retina serving much the same function as film or a CCD in a camera. The retina consists of several layers of neurons interconnected by synapses. The neural retina refers to the three layers of neural cells (photo receptor cells, bipolar cells, and ganglion cells) within

Context: Document [8](Title: Retinylidene protein) of retinal at the ground state that photoisomerizes to an all-"trans" retinal upon light activation. They are commonly found in the light-sensing organs, for example in the photoreceptor cells of vertebrate retina where they facilitate eyesight. Animal opsins can also be found in the skin of amphibians, the pineal glands of lizards and birds, the hypothalamus of toads, and the human brain. They can be categorized into several distinct classes including: The "visual purple" rhodopsin (opsin-2) of the rod cells in the vertebrate retina absorbs green-blue light. The photopsins of the cone cells of the retina differ in a few

Context: Document [9](Title: Sclera) pass. The thickness of the sclera varies from 1mm at the posterior pole to 0.3 mm just behind the rectus muscle insertions. The sclera's blood vessels are mainly on the surface. Along with the vessels of the conjunctiva (which is a thin layer covering the sclera), those in the episclera render the inflamed eye bright red. In many vertebrates, the sclera is reinforced with plates of cartilage or bone, together forming a circular structure called the sclerotic ring. In primitive fish, this ring consists of four plates, but the number is lower in many living ray-finned fishes, and much higher

Context: Document [10](Title: Retinal haemorrhage) Retinal haemorrhage Retinal haemorrhage is a disorder of the eye in which bleeding occurs in the retina, the light sensitive tissue, located on the back wall of the eye. There are photoreceptor cells in the retina called rods and cones, which transduce light energy into nerve signals that can be processed by the brain to form visual images. Retinal hemorrhage can affect adults, and newborn babies and infants may also suffer from this disorder. A retinal hemorrhage can be caused by several medical conditions such as hypertension, retinal vein occlusion (a blockage of a retinal vein), anemia, leukemia or diabetes

Context: Document [11](Title: Retinopathy) blood to sludge, or thicken and flow slowly, through the retinal arteries. Other disorders that cause hyperviscosity syndrome may also cause blood sludging. Lastly, clots or central artery thrombosis directly blocks flow to the retina causing the cells to die. Proliferative retinopathy is the result of aberrant blood flow to the retina due to blood vessel overgrowth, or neovascularization. These pathologically overgrown blood vessels are often fragile, weak, and ineffective at perfusing the retinal tissues. These weak, fragile vessels are also often leaky, allowing fluids, protein, and other debris to leech out into the retina. They are also prone to

Context: Document [12](Title: Retina) entire retina contains about 7 million cones and 75 to 150 million rods. The optic disc, a part of the retina sometimes called "the blind spot" because it lacks photoreceptors, is located at the optic papilla, where the optic-nerve fibres leave the eye. It appears as an oval white area of 3 mm². Temporal (in the direction of the temples) to this disc is the macula, at whose centre is the fovea, a pit that is responsible for our sharp central vision but is actually less sensitive to light because of its lack of rods. Human and non-human primates possess

Context: Document [13](Title: Diabetic retinopathy) show areas of retinal thickening due to fluid accumulation from macular edema. In the second stage, abnormal new blood vessels (neovascularisation) form at the back of the eye as part of "proliferative diabetic retinopathy" (PDR); these can burst and bleed (vitreous hemorrhage) and blur the vision, because these new blood vessels are fragile. The first time this bleeding occurs, it may not be very severe. In most cases, it will leave just a few specks of blood, or spots floating in a person's visual field, though the spots often go away after a few hours. These spots are often followed

Context: Document [14](Title: Epiretinal membrane) field dependent aniseikonia that cannot be fully corrected optically with glasses. Partial correction often improves the binocular vision considerably though. In the young (under 50 years of age), these cells occasionally pull free and disintegrate on their own; but in the majority of sufferers (over 60 years of age) the condition is permanent. The underlying photoreceptor cells, rod cells and cone cells, are usually not damaged unless the membrane becomes quite thick and hard; so usually there is no macular degeneration. The source of the cells in epiretinal membranes (ERM) has been found to comprise glial cells, retinal pigment epithelial

Context: Document [15](Title: Special senses) light from its surroundings onto a light-sensitive membrane in the back of the eye, called the retina. The retina is actually part of the brain that is isolated to serve as a transducer for the conversion of light into neuronal signals. Based on feedback from the visual system, the lens of the eye adjusts its thickness to focus light on the photoreceptive cells of the retina, also known as the rods and cones, which detect the photons of light and respond by producing neural impulses. These signals are processed via complex feedforward and feedback processes by different parts of the

Context: Document [16](Title: Conjunctiva) palpebral conjunctival vessels will be supplied by both the ophthalmic artery and the external carotid artery, to varying extents. Sensory innervation of the conjunctiva is divided into four parts: The conjunctiva consists of non-keratinized, both stratified squamous and stratified columnar epithelium, with interspersed goblet cells. The epithelial layer contains blood vessels, fibrous tissue, and lymphatic channels. Accessory lacrimal glands in the conjunctiva constantly produce the aqueous portion of tears. Additional cells present in the conjunctival epithelium include melanocytes, T and B cell lymphocytes. The conjunctiva helps lubricate the eye by producing mucus and tears, although a smaller volume of tears

Context: Document [17](Title: Rubeosis iridis) VEGF. These factors stimulate the formation of new blood vessels (angiogenesis). Unfortunately, these new vessels do not have the same characteristics as the blood vessels originally formed in the eye. In addition, new blood vessels can form in areas that do not have them. Specifically, new blood vessels can be observed on the iris. In addition to the blood vessels in the iris, they can grow into the angle of the eye. These blood vessels eventually go through a process called fibrosis which closes the normal physiologic anatomy of the angle. The closing of the angle prevents fluid from leaving

Context: Document [18](Title: Retinol) (three forms/colors in humans), responsible for color vision and sensing relatively high light intensities (day vision), are less impaired at early stages of the vitamin A deficiency. All these protein-pigment complexes are located in the light-sensing cells in eye's retina. When stimulated by light, rhodopsin splits into a protein and a cofactor: opsin and all-"trans"-retinal (a form of vitamin A). The regeneration of active rhodopsin requires opsin and 11-"cis"-retinal. The regeneration of 11-"cis"-retinal occurs in vertebrates via a sequence of chemical transformations that constitute "the visual cycle" and which occurs primarily in the retinal pigmented epithelial cells. Without adequate amounts

Context: Document [19](Title: Blood–retinal barrier) Blood–retinal barrier The blood–retinal barrier, or the BRB, is part of the blood–ocular barrier that consists of cells that are joined tightly together to prevent certain substances from entering the tissue of the retina. It consists of non-fenestrated capillaries of the retinal circulation and tight-junctions between retinal epithelial cells preventing passage of large molecules from choriocapillaris into the retina. The blood retinal barrier has two components: the retinal vascular endothelium and the retinal pigment epithelium. Retinal blood vessels that are similar to cerebral blood vessels maintain the inner blood-ocular barrier. This physiological barrier comprises a single layer of non-fenestrated endothelial

Context: Document [20](Title: Optics and vision) called the retina. The retina converts patterns of light into neuronal signals. The lens of the eye focuses light on the photoreceptive cells of the retina, which detect the photons of light and respond by producing neural impulses. These signals are processed in a hierarchical fashion by different parts of the brain, from the retina to the lateral geniculate nucleus, to the primary and secondary visual cortex of the brain. Signals from the retina can also travel directly from the retina to the Superior colliculus. The human eye is an organ which reacts to light for several purposes. As a

Question: where do the blood vessels that supply the retinal cells lie?

Answer: optic nerve

Answer: The optic nerve


Context: Document [1](Title: Retina) is "wired wrongly" or "badly designed"; but in fact, the retina could not function if it were not inverted. The photoreceptor layer must be embedded in the retinal pigment epithelium (RPE), which performs at least seven vital functions, one of the most obvious being to supply oxygen and other necessary nutrients needed for the photoreceptors to function. These nutrients include glucose, fatty acids, and retinal. The mammalian photoreceptor amplification process uses large quantities energy for vision in photopic conditions (requiring less under scotopic conditions) and, thus, requires the large supply nutrients supplied by the blood vessels in the choroid, which

Context: Document [2](Title: Retina) of the forkhead transcription factors FOXD1 and FOXG1. Additional gradients are formed within the retina that aid in proper targeting of RGC axons that function to establish the retinotopic map. The retina is stratified into distinct layers, each containing specific cell types or cellular compartments that have metabolisms with different nutritional requirements. To satisfy these requirements, the ophthalmic artery bifurcates and supplies the retina via two distinct vascular networks: the choroidal network, which supplies the choroid and the outer retina, and the retinal network, which supplies the retina's inner layer. At first glance, one may think that the vertebrate retina

Context: Document [3](Title: Retina) lies beyond the RPE. The choroid supplies about 75% of these nutrients to the retina and the retinal vasculature only 25%. When light strikes 11-cis-retinal (in the disks in the rods and cones), 11-cis-retinal changes to all-trans-retinal which then triggers changes in the opsins. Now, the outer segments do not regenerate the retinal back into the cis- form once it has been changed by light. Instead the retinal is pumped out to the surrounding RPE where it is regenerated and transported back into the outer segments of the photoreceptors. This recycling function of the RPE protects the photoreceptors against photo-oxidative

Context: Document [4](Title: Conjunctiva) Conjunctiva The conjunctiva lines the inside of the eyelids and covers the sclera (the white of the eye). It is composed of non-keratinized, stratified squamous epithelium with goblet cells, and also stratified columnar epithelium. The conjunctiva is highly vascularised, with many microvessels easily accessible for imaging studies. The conjunctiva is typically divided into three parts: Blood to the bulbar conjunctiva is primarily derived from the ophthalmic artery. The blood supply to the palpebral conjunctiva (the eyelid) is derived from the external carotid artery. However, the circulation of the bulbar conjunctiva and palpebral conjunctiva are linked, so both bulbar conjunctival and

Context: Document [5](Title: Eye) pigment epithelium, and constitutes the cells of the dilator muscle. The vitreous is the transparent, colourless, gelatinous mass that fills the space between the lens of the eye and the retina lining the back of the eye. It is produced by certain retinal cells. It is of rather similar composition to the cornea, but contains very few cells (mostly phagocytes which remove unwanted cellular debris in the visual field, as well as the hyalocytes of Balazs of the surface of the vitreous, which reprocess the hyaluronic acid), no blood vessels, and 98–99% of its volume is water (as opposed to

Context: Document [6](Title: Retina) Retina The retina is the innermost, light-sensitive layer, or "coat", of shell tissue of the eye of most vertebrates and some molluscs. The optics of the eye create a focused two-dimensional image of the visual world on the retina, which translates that image into electrical neural impulses to the brain to create visual perception, the retina serving much the same function as film or a CCD in a camera. The retina consists of several layers of neurons interconnected by synapses. The neural retina refers to the three layers of neural cells (photo receptor cells, bipolar cells, and ganglion cells) within

Context: Document [7](Title: Retinylidene protein) of retinal at the ground state that photoisomerizes to an all-"trans" retinal upon light activation. They are commonly found in the light-sensing organs, for example in the photoreceptor cells of vertebrate retina where they facilitate eyesight. Animal opsins can also be found in the skin of amphibians, the pineal glands of lizards and birds, the hypothalamus of toads, and the human brain. They can be categorized into several distinct classes including: The "visual purple" rhodopsin (opsin-2) of the rod cells in the vertebrate retina absorbs green-blue light. The photopsins of the cone cells of the retina differ in a few

Context: Document [8](Title: Sclera) pass. The thickness of the sclera varies from 1mm at the posterior pole to 0.3 mm just behind the rectus muscle insertions. The sclera's blood vessels are mainly on the surface. Along with the vessels of the conjunctiva (which is a thin layer covering the sclera), those in the episclera render the inflamed eye bright red. In many vertebrates, the sclera is reinforced with plates of cartilage or bone, together forming a circular structure called the sclerotic ring. In primitive fish, this ring consists of four plates, but the number is lower in many living ray-finned fishes, and much higher

Context: Document [9](Title: Retinal haemorrhage) Retinal haemorrhage Retinal haemorrhage is a disorder of the eye in which bleeding occurs in the retina, the light sensitive tissue, located on the back wall of the eye. There are photoreceptor cells in the retina called rods and cones, which transduce light energy into nerve signals that can be processed by the brain to form visual images. Retinal hemorrhage can affect adults, and newborn babies and infants may also suffer from this disorder. A retinal hemorrhage can be caused by several medical conditions such as hypertension, retinal vein occlusion (a blockage of a retinal vein), anemia, leukemia or diabetes

Context: Document [10](Title: Retina) In section, the retina is no more than 0.5 mm thick. It has three layers of nerve cells and two of synapses, including the unique ribbon synapse. The optic nerve carries the ganglion cell axons to the brain, and the blood vessels that supply the retina. The ganglion cells lie innermost in the eye while the photoreceptive cells lie beyond. Because of this counter-intuitive arrangement, light must first pass through and around the ganglion cells and through the thickness of the retina, (including its capillary vessels, not shown) before reaching the rods and cones. Light is absorbed by the retinal

Context: Document [11](Title: Retinopathy) blood to sludge, or thicken and flow slowly, through the retinal arteries. Other disorders that cause hyperviscosity syndrome may also cause blood sludging. Lastly, clots or central artery thrombosis directly blocks flow to the retina causing the cells to die. Proliferative retinopathy is the result of aberrant blood flow to the retina due to blood vessel overgrowth, or neovascularization. These pathologically overgrown blood vessels are often fragile, weak, and ineffective at perfusing the retinal tissues. These weak, fragile vessels are also often leaky, allowing fluids, protein, and other debris to leech out into the retina. They are also prone to

Context: Document [12](Title: Retina) entire retina contains about 7 million cones and 75 to 150 million rods. The optic disc, a part of the retina sometimes called "the blind spot" because it lacks photoreceptors, is located at the optic papilla, where the optic-nerve fibres leave the eye. It appears as an oval white area of 3 mm². Temporal (in the direction of the temples) to this disc is the macula, at whose centre is the fovea, a pit that is responsible for our sharp central vision but is actually less sensitive to light because of its lack of rods. Human and non-human primates possess

Context: Document [13](Title: Diabetic retinopathy) show areas of retinal thickening due to fluid accumulation from macular edema. In the second stage, abnormal new blood vessels (neovascularisation) form at the back of the eye as part of "proliferative diabetic retinopathy" (PDR); these can burst and bleed (vitreous hemorrhage) and blur the vision, because these new blood vessels are fragile. The first time this bleeding occurs, it may not be very severe. In most cases, it will leave just a few specks of blood, or spots floating in a person's visual field, though the spots often go away after a few hours. These spots are often followed

Context: Document [14](Title: Epiretinal membrane) field dependent aniseikonia that cannot be fully corrected optically with glasses. Partial correction often improves the binocular vision considerably though. In the young (under 50 years of age), these cells occasionally pull free and disintegrate on their own; but in the majority of sufferers (over 60 years of age) the condition is permanent. The underlying photoreceptor cells, rod cells and cone cells, are usually not damaged unless the membrane becomes quite thick and hard; so usually there is no macular degeneration. The source of the cells in epiretinal membranes (ERM) has been found to comprise glial cells, retinal pigment epithelial

Context: Document [15](Title: Special senses) light from its surroundings onto a light-sensitive membrane in the back of the eye, called the retina. The retina is actually part of the brain that is isolated to serve as a transducer for the conversion of light into neuronal signals. Based on feedback from the visual system, the lens of the eye adjusts its thickness to focus light on the photoreceptive cells of the retina, also known as the rods and cones, which detect the photons of light and respond by producing neural impulses. These signals are processed via complex feedforward and feedback processes by different parts of the

Context: Document [16](Title: Conjunctiva) palpebral conjunctival vessels will be supplied by both the ophthalmic artery and the external carotid artery, to varying extents. Sensory innervation of the conjunctiva is divided into four parts: The conjunctiva consists of non-keratinized, both stratified squamous and stratified columnar epithelium, with interspersed goblet cells. The epithelial layer contains blood vessels, fibrous tissue, and lymphatic channels. Accessory lacrimal glands in the conjunctiva constantly produce the aqueous portion of tears. Additional cells present in the conjunctival epithelium include melanocytes, T and B cell lymphocytes. The conjunctiva helps lubricate the eye by producing mucus and tears, although a smaller volume of tears

Context: Document [17](Title: Rubeosis iridis) VEGF. These factors stimulate the formation of new blood vessels (angiogenesis). Unfortunately, these new vessels do not have the same characteristics as the blood vessels originally formed in the eye. In addition, new blood vessels can form in areas that do not have them. Specifically, new blood vessels can be observed on the iris. In addition to the blood vessels in the iris, they can grow into the angle of the eye. These blood vessels eventually go through a process called fibrosis which closes the normal physiologic anatomy of the angle. The closing of the angle prevents fluid from leaving

Context: Document [18](Title: Retinol) (three forms/colors in humans), responsible for color vision and sensing relatively high light intensities (day vision), are less impaired at early stages of the vitamin A deficiency. All these protein-pigment complexes are located in the light-sensing cells in eye's retina. When stimulated by light, rhodopsin splits into a protein and a cofactor: opsin and all-"trans"-retinal (a form of vitamin A). The regeneration of active rhodopsin requires opsin and 11-"cis"-retinal. The regeneration of 11-"cis"-retinal occurs in vertebrates via a sequence of chemical transformations that constitute "the visual cycle" and which occurs primarily in the retinal pigmented epithelial cells. Without adequate amounts

Context: Document [19](Title: Blood–retinal barrier) Blood–retinal barrier The blood–retinal barrier, or the BRB, is part of the blood–ocular barrier that consists of cells that are joined tightly together to prevent certain substances from entering the tissue of the retina. It consists of non-fenestrated capillaries of the retinal circulation and tight-junctions between retinal epithelial cells preventing passage of large molecules from choriocapillaris into the retina. The blood retinal barrier has two components: the retinal vascular endothelium and the retinal pigment epithelium. Retinal blood vessels that are similar to cerebral blood vessels maintain the inner blood-ocular barrier. This physiological barrier comprises a single layer of non-fenestrated endothelial

Context: Document [20](Title: Optics and vision) called the retina. The retina converts patterns of light into neuronal signals. The lens of the eye focuses light on the photoreceptive cells of the retina, which detect the photons of light and respond by producing neural impulses. These signals are processed in a hierarchical fashion by different parts of the brain, from the retina to the lateral geniculate nucleus, to the primary and secondary visual cortex of the brain. Signals from the retina can also travel directly from the retina to the Superior colliculus. The human eye is an organ which reacts to light for several purposes. As a

Question: where do the blood vessels that supply the retinal cells lie?

Answer: optic nerve

Answer: The optic nerve


Context: Document [1](Title: Retina) is "wired wrongly" or "badly designed"; but in fact, the retina could not function if it were not inverted. The photoreceptor layer must be embedded in the retinal pigment epithelium (RPE), which performs at least seven vital functions, one of the most obvious being to supply oxygen and other necessary nutrients needed for the photoreceptors to function. These nutrients include glucose, fatty acids, and retinal. The mammalian photoreceptor amplification process uses large quantities energy for vision in photopic conditions (requiring less under scotopic conditions) and, thus, requires the large supply nutrients supplied by the blood vessels in the choroid, which

Context: Document [2](Title: Retina) of the forkhead transcription factors FOXD1 and FOXG1. Additional gradients are formed within the retina that aid in proper targeting of RGC axons that function to establish the retinotopic map. The retina is stratified into distinct layers, each containing specific cell types or cellular compartments that have metabolisms with different nutritional requirements. To satisfy these requirements, the ophthalmic artery bifurcates and supplies the retina via two distinct vascular networks: the choroidal network, which supplies the choroid and the outer retina, and the retinal network, which supplies the retina's inner layer. At first glance, one may think that the vertebrate retina

Context: Document [3](Title: Retina) lies beyond the RPE. The choroid supplies about 75% of these nutrients to the retina and the retinal vasculature only 25%. When light strikes 11-cis-retinal (in the disks in the rods and cones), 11-cis-retinal changes to all-trans-retinal which then triggers changes in the opsins. Now, the outer segments do not regenerate the retinal back into the cis- form once it has been changed by light. Instead the retinal is pumped out to the surrounding RPE where it is regenerated and transported back into the outer segments of the photoreceptors. This recycling function of the RPE protects the photoreceptors against photo-oxidative

Context: Document [4](Title: Conjunctiva) Conjunctiva The conjunctiva lines the inside of the eyelids and covers the sclera (the white of the eye). It is composed of non-keratinized, stratified squamous epithelium with goblet cells, and also stratified columnar epithelium. The conjunctiva is highly vascularised, with many microvessels easily accessible for imaging studies. The conjunctiva is typically divided into three parts: Blood to the bulbar conjunctiva is primarily derived from the ophthalmic artery. The blood supply to the palpebral conjunctiva (the eyelid) is derived from the external carotid artery. However, the circulation of the bulbar conjunctiva and palpebral conjunctiva are linked, so both bulbar conjunctival and

Context: Document [5](Title: Eye) pigment epithelium, and constitutes the cells of the dilator muscle. The vitreous is the transparent, colourless, gelatinous mass that fills the space between the lens of the eye and the retina lining the back of the eye. It is produced by certain retinal cells. It is of rather similar composition to the cornea, but contains very few cells (mostly phagocytes which remove unwanted cellular debris in the visual field, as well as the hyalocytes of Balazs of the surface of the vitreous, which reprocess the hyaluronic acid), no blood vessels, and 98–99% of its volume is water (as opposed to

Context: Document [6](Title: Retina) Retina The retina is the innermost, light-sensitive layer, or "coat", of shell tissue of the eye of most vertebrates and some molluscs. The optics of the eye create a focused two-dimensional image of the visual world on the retina, which translates that image into electrical neural impulses to the brain to create visual perception, the retina serving much the same function as film or a CCD in a camera. The retina consists of several layers of neurons interconnected by synapses. The neural retina refers to the three layers of neural cells (photo receptor cells, bipolar cells, and ganglion cells) within

Context: Document [7](Title: Retinylidene protein) of retinal at the ground state that photoisomerizes to an all-"trans" retinal upon light activation. They are commonly found in the light-sensing organs, for example in the photoreceptor cells of vertebrate retina where they facilitate eyesight. Animal opsins can also be found in the skin of amphibians, the pineal glands of lizards and birds, the hypothalamus of toads, and the human brain. They can be categorized into several distinct classes including: The "visual purple" rhodopsin (opsin-2) of the rod cells in the vertebrate retina absorbs green-blue light. The photopsins of the cone cells of the retina differ in a few

Context: Document [8](Title: Sclera) pass. The thickness of the sclera varies from 1mm at the posterior pole to 0.3 mm just behind the rectus muscle insertions. The sclera's blood vessels are mainly on the surface. Along with the vessels of the conjunctiva (which is a thin layer covering the sclera), those in the episclera render the inflamed eye bright red. In many vertebrates, the sclera is reinforced with plates of cartilage or bone, together forming a circular structure called the sclerotic ring. In primitive fish, this ring consists of four plates, but the number is lower in many living ray-finned fishes, and much higher

Context: Document [9](Title: Retinal haemorrhage) Retinal haemorrhage Retinal haemorrhage is a disorder of the eye in which bleeding occurs in the retina, the light sensitive tissue, located on the back wall of the eye. There are photoreceptor cells in the retina called rods and cones, which transduce light energy into nerve signals that can be processed by the brain to form visual images. Retinal hemorrhage can affect adults, and newborn babies and infants may also suffer from this disorder. A retinal hemorrhage can be caused by several medical conditions such as hypertension, retinal vein occlusion (a blockage of a retinal vein), anemia, leukemia or diabetes

Context: Document [10](Title: Retinopathy) blood to sludge, or thicken and flow slowly, through the retinal arteries. Other disorders that cause hyperviscosity syndrome may also cause blood sludging. Lastly, clots or central artery thrombosis directly blocks flow to the retina causing the cells to die. Proliferative retinopathy is the result of aberrant blood flow to the retina due to blood vessel overgrowth, or neovascularization. These pathologically overgrown blood vessels are often fragile, weak, and ineffective at perfusing the retinal tissues. These weak, fragile vessels are also often leaky, allowing fluids, protein, and other debris to leech out into the retina. They are also prone to

Context: Document [11](Title: Retina) entire retina contains about 7 million cones and 75 to 150 million rods. The optic disc, a part of the retina sometimes called "the blind spot" because it lacks photoreceptors, is located at the optic papilla, where the optic-nerve fibres leave the eye. It appears as an oval white area of 3 mm². Temporal (in the direction of the temples) to this disc is the macula, at whose centre is the fovea, a pit that is responsible for our sharp central vision but is actually less sensitive to light because of its lack of rods. Human and non-human primates possess

Context: Document [12](Title: Diabetic retinopathy) show areas of retinal thickening due to fluid accumulation from macular edema. In the second stage, abnormal new blood vessels (neovascularisation) form at the back of the eye as part of "proliferative diabetic retinopathy" (PDR); these can burst and bleed (vitreous hemorrhage) and blur the vision, because these new blood vessels are fragile. The first time this bleeding occurs, it may not be very severe. In most cases, it will leave just a few specks of blood, or spots floating in a person's visual field, though the spots often go away after a few hours. These spots are often followed

Context: Document [13](Title: Epiretinal membrane) field dependent aniseikonia that cannot be fully corrected optically with glasses. Partial correction often improves the binocular vision considerably though. In the young (under 50 years of age), these cells occasionally pull free and disintegrate on their own; but in the majority of sufferers (over 60 years of age) the condition is permanent. The underlying photoreceptor cells, rod cells and cone cells, are usually not damaged unless the membrane becomes quite thick and hard; so usually there is no macular degeneration. The source of the cells in epiretinal membranes (ERM) has been found to comprise glial cells, retinal pigment epithelial

Context: Document [14](Title: Special senses) light from its surroundings onto a light-sensitive membrane in the back of the eye, called the retina. The retina is actually part of the brain that is isolated to serve as a transducer for the conversion of light into neuronal signals. Based on feedback from the visual system, the lens of the eye adjusts its thickness to focus light on the photoreceptive cells of the retina, also known as the rods and cones, which detect the photons of light and respond by producing neural impulses. These signals are processed via complex feedforward and feedback processes by different parts of the

Context: Document [15](Title: Retina) In section, the retina is no more than 0.5 mm thick. It has three layers of nerve cells and two of synapses, including the unique ribbon synapse. The optic nerve carries the ganglion cell axons to the brain, and the blood vessels that supply the retina. The ganglion cells lie innermost in the eye while the photoreceptive cells lie beyond. Because of this counter-intuitive arrangement, light must first pass through and around the ganglion cells and through the thickness of the retina, (including its capillary vessels, not shown) before reaching the rods and cones. Light is absorbed by the retinal

Context: Document [16](Title: Conjunctiva) palpebral conjunctival vessels will be supplied by both the ophthalmic artery and the external carotid artery, to varying extents. Sensory innervation of the conjunctiva is divided into four parts: The conjunctiva consists of non-keratinized, both stratified squamous and stratified columnar epithelium, with interspersed goblet cells. The epithelial layer contains blood vessels, fibrous tissue, and lymphatic channels. Accessory lacrimal glands in the conjunctiva constantly produce the aqueous portion of tears. Additional cells present in the conjunctival epithelium include melanocytes, T and B cell lymphocytes. The conjunctiva helps lubricate the eye by producing mucus and tears, although a smaller volume of tears

Context: Document [17](Title: Rubeosis iridis) VEGF. These factors stimulate the formation of new blood vessels (angiogenesis). Unfortunately, these new vessels do not have the same characteristics as the blood vessels originally formed in the eye. In addition, new blood vessels can form in areas that do not have them. Specifically, new blood vessels can be observed on the iris. In addition to the blood vessels in the iris, they can grow into the angle of the eye. These blood vessels eventually go through a process called fibrosis which closes the normal physiologic anatomy of the angle. The closing of the angle prevents fluid from leaving

Context: Document [18](Title: Retinol) (three forms/colors in humans), responsible for color vision and sensing relatively high light intensities (day vision), are less impaired at early stages of the vitamin A deficiency. All these protein-pigment complexes are located in the light-sensing cells in eye's retina. When stimulated by light, rhodopsin splits into a protein and a cofactor: opsin and all-"trans"-retinal (a form of vitamin A). The regeneration of active rhodopsin requires opsin and 11-"cis"-retinal. The regeneration of 11-"cis"-retinal occurs in vertebrates via a sequence of chemical transformations that constitute "the visual cycle" and which occurs primarily in the retinal pigmented epithelial cells. Without adequate amounts

Context: Document [19](Title: Blood–retinal barrier) Blood–retinal barrier The blood–retinal barrier, or the BRB, is part of the blood–ocular barrier that consists of cells that are joined tightly together to prevent certain substances from entering the tissue of the retina. It consists of non-fenestrated capillaries of the retinal circulation and tight-junctions between retinal epithelial cells preventing passage of large molecules from choriocapillaris into the retina. The blood retinal barrier has two components: the retinal vascular endothelium and the retinal pigment epithelium. Retinal blood vessels that are similar to cerebral blood vessels maintain the inner blood-ocular barrier. This physiological barrier comprises a single layer of non-fenestrated endothelial

Context: Document [20](Title: Optics and vision) called the retina. The retina converts patterns of light into neuronal signals. The lens of the eye focuses light on the photoreceptive cells of the retina, which detect the photons of light and respond by producing neural impulses. These signals are processed in a hierarchical fashion by different parts of the brain, from the retina to the lateral geniculate nucleus, to the primary and secondary visual cortex of the brain. Signals from the retina can also travel directly from the retina to the Superior colliculus. The human eye is an organ which reacts to light for several purposes. As a

Question: where do the blood vessels that supply the retinal cells lie?

Answer: optic nerve

Answer: The optic nerve