Context: Document [1](Title: Penicillin) Penicillin was discovered in 1928 by Scottish scientist Alexander Fleming. People began using it to treat infections in 1942. There are several enhanced penicillin families which are effective against additional bacteria; these include the antistaphylococcal penicillins, aminopenicillins and the antipseudomonal penicillins. They are derived from Penicillium fungi.

Context: Document [2](Title: History of penicillin) respond to any traditional antiseptic was then given another substance that cured her, and Lister's registrar informed her that it was called Penicillium. In 1874, the Welsh physician William Roberts, who later coined the term "enzyme", observed that bacterial contamination is generally absent in laboratory cultures of "Penicillium glaucum". John Tyndall followed up on Burdon-Sanderson's work and demonstrated to the Royal Society in 1875 the antibacterial action of the "Penicillium" fungus. By this time, "Bacillus anthracis" had been shown to cause anthrax, the first demonstration that a specific bacterium caused a specific disease. In 1877, French biologists Louis Pasteur and

Context: Document [3](Title: History of penicillin) (now Sandoz) developed the first acid-stable penicillin for oral administration, Penicillin V. American chemist John C. Sheehan of the Massachusetts Institute of Technology (MIT) subsequently completed the first chemical synthesis of penicillin in 1957. The second-generation semi-synthetic β-lactam antibiotic methicillin, designed to counter first-generation-resistant penicillinases, was introduced in the United Kingdom in 1959. Methicillin-resistant forms of "Staphylococcus aureus" likely already existed at the time. History of penicillin The history of penicillin follows a number of observations and discoveries of apparent evidence of antibiotic activity in molds before the modern isolation of the chemical penicillin in 1928. There are anecdotes about

Context: Document [4](Title: History of penicillin) History of penicillin The history of penicillin follows a number of observations and discoveries of apparent evidence of antibiotic activity in molds before the modern isolation of the chemical penicillin in 1928. There are anecdotes about ancient societies using molds to treat infections, and in the following centuries many people observed the inhibition of bacterial growth by various molds. However, it is unknown if the species involved were "Penicillium" species or if the antimicrobial substances produced were penicillin. The Scottish physician Alexander Fleming was the first to suggest that a "Penicillium" mold must secrete an antibacterial substance, and the first

Context: Document [5](Title: History of penicillin) to concentrate the active substance involved, which he named penicillin, in 1928. Penicillin was the first modern antibiotic. During the next twelve years Fleming grew, distributed, and studied the original mold, which was determined to be a rare variant of "Penicillium notatum" (now "Penicillium chrysogenum"). Many later scientists were involved in the stabilization and mass production of penicillin and in the search for more productive strains of "Penicillium". Important contributors include Ernst Chain, Howard Florey, Norman Heatley, and Edward Abraham. Shortly after the discovery of penicillin, scientists found that some disease-causing pathogens display antibiotic resistance to penicillin. Research that aims

Context: Document [6](Title: Roaring Twenties) Alexander Fleming discovered a substance that killed a number of disease-causing bacteria. In 1929, he named the new substance "penicillin". His publications were largely ignored at first, but it became a significant antibiotic in the 1930s. In 1930, Cecil George Paine, a pathologist at Sheffield Royal Infirmary, used penicillin to treat sycosis barbae, eruptions in beard follicles, but was unsuccessful. Moving on to ophthalmia neonatorum, a gonococcal infection in infants, he achieved the first recorded cure with penicillin, on November 25, 1930. He then cured four additional patients (one adult and three infants) of eye infections, but failed to cure

Context: Document [7](Title: Gladys Lounsbury Hobby) 1940 and 1941, before presenting at the American Society for Clinical Investigation. They discovered that penicillin was a powerful germ-killer that reduced the severity of infectious diseases and made procedures such as organ transplantation and open-heart surgery possible. Their findings received media coverage, which helped attract funding from the United States Government to mass-produce penicillin during World War II, saving the lives of many soldiers. At Pfizer, Hobby did extensive early work on Terramycin and Viomycin, used for the treatment of tuberculosis. Gladys Lounsbury Hobby Gladys Lounsbury Hobby (November 19, 1910 – July 4, 1993), born in New York City,

Context: Document [8](Title: Penicillin) by scientists and physicians on the antibacterial properties of the different types of moulds including the mould penicillium but they were unable to discern what process was causing the effect. The effects of penicillium mould would finally be isolated in 1928 by Scottish scientist Alexander Fleming, in work that seems to have been independent of those earlier observations. Fleming recounted that the date of his discovery of penicillin was on the morning of Friday 28 September 1928. The traditional version of this story describes the discovery as a serendipitous accident: in his laboratory in the basement of St Mary's Hospital

Context: Document [9](Title: Penicillin) November 19, 1999. In 1930, Cecil George Paine, a pathologist at the Royal Infirmary in Sheffield, attempted to use penicillin to treat sycosis barbae, eruptions in beard follicles, but was unsuccessful. Moving on to ophthalmia neonatorum, a gonococcal infection in infants, he achieved the first recorded cure with penicillin, on November 25, 1930. He then cured four additional patients (one adult and three infants) of eye infections, and failed to cure a fifth. In 1939, Australian scientist Howard Florey (later Baron Florey) and a team of researchers (Ernst Boris Chain, Edward Abraham, Arthur Duncan Gardner, Norman Heatley, M. Jennings, J.

Context: Document [10](Title: Albert Alexander (police officer)) murder, the purification invites disaster.” Nonetheless, by March 15, 1945, supplies of penicillin were not only available to American troops, but to the American public, as war-time restrictions on availability were lifted. Albert Alexander (police officer) Reserve Constable Albert Alexander (1896 – 15 March 1941) was the first patient to be treated with injections of penicillin. Albert Alexander was a constable in the police force of the County of Oxford, England. In December 1940, Constable Alexander was accidentally scratched by a rose thorn on his face. By the end of the month, the scratch was badly infected with both "Staphylococcus"

Context: Document [11](Title: La Follette-Bulwinkle Act) Cosmetic Act Penicillin Amendment on July 6, 1945. The United States public law required the U.S. Food and Drug Administration to certify and test penicillin samplings validating the effectiveness, potency, purification, and safety of the antibiotic drugs. The 1960s sexual revolution movement prompt the United States Congress to draft amendments for the Public Health Service Act authorizing control, prevention, and vaccination assistance for communicable diseases. The United States statutes were enacted into law by the 37th President of the United States Richard Nixon and the 38th President of the United States Gerald Ford. By 1914, American exploitation films were produced

Context: Document [12](Title: History of penicillin) earnest in the 1870s, in the United Kingdom. Sir John Scott Burdon-Sanderson, who started out at St. Mary's Hospital (1852–1858) and later worked there as a lecturer (1854–1862), observed that culture fluid covered with mold would produce no bacterial growth. Burdon-Sanderson's discovery prompted Joseph Lister, an English surgeon and the father of modern antisepsis, to discover in 1871 that urine samples contaminated with mold also did not permit the growth of bacteria. Lister also described the antibacterial action on human tissue of a species of mold he called "Penicillium glaucum". A nurse at King's College Hospital whose wounds did not

Context: Document [13](Title: Martin Henry Dawson) prepare it and use it in human disease. This included the successful treatment of bacterial endocarditis with penicillin, and the use of gold salts in the treatment of rheumatoid arthritis. Dawson became the first person in history to stick a needle full of an antibiotic (penicillin) into a patient, on October 16, 1940. After he had graduated Dalhousie University in Halifax with a BA in 1916 he started serving in the Canadian forces in the First World War. Pte. M. Henry Dawson was with No. 7 Stationary Hospital at La Harve, France. He became a Capt. in the Nova Scotia

Context: Document [14](Title: Vincenzo Tiberio) connection anticipated the discovery of the drug penicillin by Alexander Fleming thirty-five years later (see: Penicillin - Discovery). At the time, his work was disregarded as coincidence and received no further study. Vincenzo Tiberio Vincenzo Tiberio (May 1, 1869 – January 7, 1915) was an Italian researcher and medical officer of the Medical Corps of the Italian Navy and physician at the University of Naples. During his medical studies at the Faculty of Medicine in Naples he noticed that when the walls of a well which supplied drinking water was cleaned off, the people who drank the well’s water complained

Context: Document [15](Title: Penicillium chrysogenum) a fermenter. The mold is grown in a liquid culture containing sugar and other nutrients including a source of nitrogen. As the mold grows, it uses up the sugar and starts to make penicillin only after using up most of the nutrients for growth. Penicillin was discovered in 1928 when Alexander Fleming's lab assistant accidentally left a window open overnight and mold spores covered his "Staphylococcus" bacterial specimens in a Petri dish. At first, Fleming was very irritated at the contamination, but as he was about to throw the specimens away, he noticed something interesting. He looked under the microscope

Context: Document [16](Title: Biotechnology) – to form what we today know as penicillin. In 1940, penicillin became available for medicinal use to treat bacterial infections in humans. The field of modern biotechnology is generally thought of as having been born in 1971 when Paul Berg's (Stanford) experiments in gene splicing had early success. Herbert W. Boyer (Univ. Calif. at San Francisco) and Stanley N. Cohen (Stanford) significantly advanced the new technology in 1972 by transferring genetic material into a bacterium, such that the imported material would be reproduced. The commercial viability of a biotechnology industry was significantly expanded on June 16, 1980, when the

Context: Document [17](Title: Norman Heatley) to a PhD in 1936, and he then moved to Oxford where he became a fellow of Lincoln College at the University of Oxford and joined a team working under Howard Florey, which also included Ernst Chain. Alexander Fleming had first discovered penicillin by accident in 1928, but at that time believed it had little application. When Florey and his team recognised the potential of the discovery for combating bacterial infection, they faced the problem of how to manufacture penicillin in sufficient quantities to be of use. Heatley, although the junior member of the team, possessed a natural gift for

Context: Document [18](Title: History of penicillin) and subsequently concentrated what he later named "penicillin". During the next twelve years, Fleming grew and distributed the original mold, which was eventually identified as "Penicillium notatum" (now known as "Penicillium chrysogenum"). He was unsuccessful in making a stable form of it for mass production. Cecil George Paine, a pathologist at the Royal Infirmary in Sheffield, attempted to treat sycosis (eruptions in beard follicles) with penicillin but was unsuccessful, probably because the drug did not penetrate deep enough. Moving on to ophthalmia neonatorum, a gonococcal infection in babies, he achieved the first cure on 25 November 1930. He cured four

Context: Document [19](Title: History of penicillin) patients (one adult, the others infants) of eye infections, although a fifth patient was not so lucky. At Oxford, Howard Walter Florey organized a large and very skilled biochemical research team, notable among them Ernst Boris Chain and Norman Heatley, to undertake clinical trials and produce a stable penicillin in quantity. In 1940, Chain and Edward Abraham reported the first indication of antibiotic resistance to penicillin, an "E. coli" strain that produced the penicillinase enzyme, which was capable of breaking down penicillin and completely negating its antibacterial effect. Between 1941 and 1943, Moyer, Coghill and Raper at the USDA Northern

Context: Document [20](Title: Grünenthal) prohibited the research and manufacture of penicillin by German companies. When the ban was lifted, Grünenthal was the first company to introduce penicillin in the postwar period into the German market. This investment achieved a big financial boost for the company. Chemie Grünenthal synthesized thalidomide in 1954 and acquired a 20-year patent. Soon after obtaining a patent in April 1954, the company started clinical trials, and as early as November 1956, marketed the drug for the treatment of respiratory infections under the trade name Grippex, a combination drug that contained thalidomide, quinine, vitamin C, phenacetin, and acetylsalicylic acid. Researchers at

Question: when was penicillin first introduced to the public?

Answer: After World War II

Answer: 1942


Context: Document [1](Title: History of penicillin) respond to any traditional antiseptic was then given another substance that cured her, and Lister's registrar informed her that it was called Penicillium. In 1874, the Welsh physician William Roberts, who later coined the term "enzyme", observed that bacterial contamination is generally absent in laboratory cultures of "Penicillium glaucum". John Tyndall followed up on Burdon-Sanderson's work and demonstrated to the Royal Society in 1875 the antibacterial action of the "Penicillium" fungus. By this time, "Bacillus anthracis" had been shown to cause anthrax, the first demonstration that a specific bacterium caused a specific disease. In 1877, French biologists Louis Pasteur and

Context: Document [2](Title: History of penicillin) (now Sandoz) developed the first acid-stable penicillin for oral administration, Penicillin V. American chemist John C. Sheehan of the Massachusetts Institute of Technology (MIT) subsequently completed the first chemical synthesis of penicillin in 1957. The second-generation semi-synthetic β-lactam antibiotic methicillin, designed to counter first-generation-resistant penicillinases, was introduced in the United Kingdom in 1959. Methicillin-resistant forms of "Staphylococcus aureus" likely already existed at the time. History of penicillin The history of penicillin follows a number of observations and discoveries of apparent evidence of antibiotic activity in molds before the modern isolation of the chemical penicillin in 1928. There are anecdotes about

Context: Document [3](Title: History of penicillin) History of penicillin The history of penicillin follows a number of observations and discoveries of apparent evidence of antibiotic activity in molds before the modern isolation of the chemical penicillin in 1928. There are anecdotes about ancient societies using molds to treat infections, and in the following centuries many people observed the inhibition of bacterial growth by various molds. However, it is unknown if the species involved were "Penicillium" species or if the antimicrobial substances produced were penicillin. The Scottish physician Alexander Fleming was the first to suggest that a "Penicillium" mold must secrete an antibacterial substance, and the first

Context: Document [4](Title: History of penicillin) to concentrate the active substance involved, which he named penicillin, in 1928. Penicillin was the first modern antibiotic. During the next twelve years Fleming grew, distributed, and studied the original mold, which was determined to be a rare variant of "Penicillium notatum" (now "Penicillium chrysogenum"). Many later scientists were involved in the stabilization and mass production of penicillin and in the search for more productive strains of "Penicillium". Important contributors include Ernst Chain, Howard Florey, Norman Heatley, and Edward Abraham. Shortly after the discovery of penicillin, scientists found that some disease-causing pathogens display antibiotic resistance to penicillin. Research that aims

Context: Document [5](Title: Penicillin) Penicillin was discovered in 1928 by Scottish scientist Alexander Fleming. People began using it to treat infections in 1942. There are several enhanced penicillin families which are effective against additional bacteria; these include the antistaphylococcal penicillins, aminopenicillins and the antipseudomonal penicillins. They are derived from Penicillium fungi.

Context: Document [6](Title: Roaring Twenties) Alexander Fleming discovered a substance that killed a number of disease-causing bacteria. In 1929, he named the new substance "penicillin". His publications were largely ignored at first, but it became a significant antibiotic in the 1930s. In 1930, Cecil George Paine, a pathologist at Sheffield Royal Infirmary, used penicillin to treat sycosis barbae, eruptions in beard follicles, but was unsuccessful. Moving on to ophthalmia neonatorum, a gonococcal infection in infants, he achieved the first recorded cure with penicillin, on November 25, 1930. He then cured four additional patients (one adult and three infants) of eye infections, but failed to cure

Context: Document [7](Title: Gladys Lounsbury Hobby) 1940 and 1941, before presenting at the American Society for Clinical Investigation. They discovered that penicillin was a powerful germ-killer that reduced the severity of infectious diseases and made procedures such as organ transplantation and open-heart surgery possible. Their findings received media coverage, which helped attract funding from the United States Government to mass-produce penicillin during World War II, saving the lives of many soldiers. At Pfizer, Hobby did extensive early work on Terramycin and Viomycin, used for the treatment of tuberculosis. Gladys Lounsbury Hobby Gladys Lounsbury Hobby (November 19, 1910 – July 4, 1993), born in New York City,

Context: Document [8](Title: Penicillin) by scientists and physicians on the antibacterial properties of the different types of moulds including the mould penicillium but they were unable to discern what process was causing the effect. The effects of penicillium mould would finally be isolated in 1928 by Scottish scientist Alexander Fleming, in work that seems to have been independent of those earlier observations. Fleming recounted that the date of his discovery of penicillin was on the morning of Friday 28 September 1928. The traditional version of this story describes the discovery as a serendipitous accident: in his laboratory in the basement of St Mary's Hospital

Context: Document [9](Title: Penicillin) November 19, 1999. In 1930, Cecil George Paine, a pathologist at the Royal Infirmary in Sheffield, attempted to use penicillin to treat sycosis barbae, eruptions in beard follicles, but was unsuccessful. Moving on to ophthalmia neonatorum, a gonococcal infection in infants, he achieved the first recorded cure with penicillin, on November 25, 1930. He then cured four additional patients (one adult and three infants) of eye infections, and failed to cure a fifth. In 1939, Australian scientist Howard Florey (later Baron Florey) and a team of researchers (Ernst Boris Chain, Edward Abraham, Arthur Duncan Gardner, Norman Heatley, M. Jennings, J.

Context: Document [10](Title: Albert Alexander (police officer)) murder, the purification invites disaster.” Nonetheless, by March 15, 1945, supplies of penicillin were not only available to American troops, but to the American public, as war-time restrictions on availability were lifted. Albert Alexander (police officer) Reserve Constable Albert Alexander (1896 – 15 March 1941) was the first patient to be treated with injections of penicillin. Albert Alexander was a constable in the police force of the County of Oxford, England. In December 1940, Constable Alexander was accidentally scratched by a rose thorn on his face. By the end of the month, the scratch was badly infected with both "Staphylococcus"

Context: Document [11](Title: La Follette-Bulwinkle Act) Cosmetic Act Penicillin Amendment on July 6, 1945. The United States public law required the U.S. Food and Drug Administration to certify and test penicillin samplings validating the effectiveness, potency, purification, and safety of the antibiotic drugs. The 1960s sexual revolution movement prompt the United States Congress to draft amendments for the Public Health Service Act authorizing control, prevention, and vaccination assistance for communicable diseases. The United States statutes were enacted into law by the 37th President of the United States Richard Nixon and the 38th President of the United States Gerald Ford. By 1914, American exploitation films were produced

Context: Document [12](Title: History of penicillin) earnest in the 1870s, in the United Kingdom. Sir John Scott Burdon-Sanderson, who started out at St. Mary's Hospital (1852–1858) and later worked there as a lecturer (1854–1862), observed that culture fluid covered with mold would produce no bacterial growth. Burdon-Sanderson's discovery prompted Joseph Lister, an English surgeon and the father of modern antisepsis, to discover in 1871 that urine samples contaminated with mold also did not permit the growth of bacteria. Lister also described the antibacterial action on human tissue of a species of mold he called "Penicillium glaucum". A nurse at King's College Hospital whose wounds did not

Context: Document [13](Title: Martin Henry Dawson) prepare it and use it in human disease. This included the successful treatment of bacterial endocarditis with penicillin, and the use of gold salts in the treatment of rheumatoid arthritis. Dawson became the first person in history to stick a needle full of an antibiotic (penicillin) into a patient, on October 16, 1940. After he had graduated Dalhousie University in Halifax with a BA in 1916 he started serving in the Canadian forces in the First World War. Pte. M. Henry Dawson was with No. 7 Stationary Hospital at La Harve, France. He became a Capt. in the Nova Scotia

Context: Document [14](Title: Vincenzo Tiberio) connection anticipated the discovery of the drug penicillin by Alexander Fleming thirty-five years later (see: Penicillin - Discovery). At the time, his work was disregarded as coincidence and received no further study. Vincenzo Tiberio Vincenzo Tiberio (May 1, 1869 – January 7, 1915) was an Italian researcher and medical officer of the Medical Corps of the Italian Navy and physician at the University of Naples. During his medical studies at the Faculty of Medicine in Naples he noticed that when the walls of a well which supplied drinking water was cleaned off, the people who drank the well’s water complained

Context: Document [15](Title: Penicillium chrysogenum) a fermenter. The mold is grown in a liquid culture containing sugar and other nutrients including a source of nitrogen. As the mold grows, it uses up the sugar and starts to make penicillin only after using up most of the nutrients for growth. Penicillin was discovered in 1928 when Alexander Fleming's lab assistant accidentally left a window open overnight and mold spores covered his "Staphylococcus" bacterial specimens in a Petri dish. At first, Fleming was very irritated at the contamination, but as he was about to throw the specimens away, he noticed something interesting. He looked under the microscope

Context: Document [16](Title: Biotechnology) – to form what we today know as penicillin. In 1940, penicillin became available for medicinal use to treat bacterial infections in humans. The field of modern biotechnology is generally thought of as having been born in 1971 when Paul Berg's (Stanford) experiments in gene splicing had early success. Herbert W. Boyer (Univ. Calif. at San Francisco) and Stanley N. Cohen (Stanford) significantly advanced the new technology in 1972 by transferring genetic material into a bacterium, such that the imported material would be reproduced. The commercial viability of a biotechnology industry was significantly expanded on June 16, 1980, when the

Context: Document [17](Title: Norman Heatley) to a PhD in 1936, and he then moved to Oxford where he became a fellow of Lincoln College at the University of Oxford and joined a team working under Howard Florey, which also included Ernst Chain. Alexander Fleming had first discovered penicillin by accident in 1928, but at that time believed it had little application. When Florey and his team recognised the potential of the discovery for combating bacterial infection, they faced the problem of how to manufacture penicillin in sufficient quantities to be of use. Heatley, although the junior member of the team, possessed a natural gift for

Context: Document [18](Title: History of penicillin) and subsequently concentrated what he later named "penicillin". During the next twelve years, Fleming grew and distributed the original mold, which was eventually identified as "Penicillium notatum" (now known as "Penicillium chrysogenum"). He was unsuccessful in making a stable form of it for mass production. Cecil George Paine, a pathologist at the Royal Infirmary in Sheffield, attempted to treat sycosis (eruptions in beard follicles) with penicillin but was unsuccessful, probably because the drug did not penetrate deep enough. Moving on to ophthalmia neonatorum, a gonococcal infection in babies, he achieved the first cure on 25 November 1930. He cured four

Context: Document [19](Title: History of penicillin) patients (one adult, the others infants) of eye infections, although a fifth patient was not so lucky. At Oxford, Howard Walter Florey organized a large and very skilled biochemical research team, notable among them Ernst Boris Chain and Norman Heatley, to undertake clinical trials and produce a stable penicillin in quantity. In 1940, Chain and Edward Abraham reported the first indication of antibiotic resistance to penicillin, an "E. coli" strain that produced the penicillinase enzyme, which was capable of breaking down penicillin and completely negating its antibacterial effect. Between 1941 and 1943, Moyer, Coghill and Raper at the USDA Northern

Context: Document [20](Title: Grünenthal) prohibited the research and manufacture of penicillin by German companies. When the ban was lifted, Grünenthal was the first company to introduce penicillin in the postwar period into the German market. This investment achieved a big financial boost for the company. Chemie Grünenthal synthesized thalidomide in 1954 and acquired a 20-year patent. Soon after obtaining a patent in April 1954, the company started clinical trials, and as early as November 1956, marketed the drug for the treatment of respiratory infections under the trade name Grippex, a combination drug that contained thalidomide, quinine, vitamin C, phenacetin, and acetylsalicylic acid. Researchers at

Question: when was penicillin first introduced to the public?

Answer: After World War II

Answer: 1942


Context: Document [1](Title: History of penicillin) respond to any traditional antiseptic was then given another substance that cured her, and Lister's registrar informed her that it was called Penicillium. In 1874, the Welsh physician William Roberts, who later coined the term "enzyme", observed that bacterial contamination is generally absent in laboratory cultures of "Penicillium glaucum". John Tyndall followed up on Burdon-Sanderson's work and demonstrated to the Royal Society in 1875 the antibacterial action of the "Penicillium" fungus. By this time, "Bacillus anthracis" had been shown to cause anthrax, the first demonstration that a specific bacterium caused a specific disease. In 1877, French biologists Louis Pasteur and

Context: Document [2](Title: History of penicillin) (now Sandoz) developed the first acid-stable penicillin for oral administration, Penicillin V. American chemist John C. Sheehan of the Massachusetts Institute of Technology (MIT) subsequently completed the first chemical synthesis of penicillin in 1957. The second-generation semi-synthetic β-lactam antibiotic methicillin, designed to counter first-generation-resistant penicillinases, was introduced in the United Kingdom in 1959. Methicillin-resistant forms of "Staphylococcus aureus" likely already existed at the time. History of penicillin The history of penicillin follows a number of observations and discoveries of apparent evidence of antibiotic activity in molds before the modern isolation of the chemical penicillin in 1928. There are anecdotes about

Context: Document [3](Title: History of penicillin) History of penicillin The history of penicillin follows a number of observations and discoveries of apparent evidence of antibiotic activity in molds before the modern isolation of the chemical penicillin in 1928. There are anecdotes about ancient societies using molds to treat infections, and in the following centuries many people observed the inhibition of bacterial growth by various molds. However, it is unknown if the species involved were "Penicillium" species or if the antimicrobial substances produced were penicillin. The Scottish physician Alexander Fleming was the first to suggest that a "Penicillium" mold must secrete an antibacterial substance, and the first

Context: Document [4](Title: History of penicillin) to concentrate the active substance involved, which he named penicillin, in 1928. Penicillin was the first modern antibiotic. During the next twelve years Fleming grew, distributed, and studied the original mold, which was determined to be a rare variant of "Penicillium notatum" (now "Penicillium chrysogenum"). Many later scientists were involved in the stabilization and mass production of penicillin and in the search for more productive strains of "Penicillium". Important contributors include Ernst Chain, Howard Florey, Norman Heatley, and Edward Abraham. Shortly after the discovery of penicillin, scientists found that some disease-causing pathogens display antibiotic resistance to penicillin. Research that aims

Context: Document [5](Title: Roaring Twenties) Alexander Fleming discovered a substance that killed a number of disease-causing bacteria. In 1929, he named the new substance "penicillin". His publications were largely ignored at first, but it became a significant antibiotic in the 1930s. In 1930, Cecil George Paine, a pathologist at Sheffield Royal Infirmary, used penicillin to treat sycosis barbae, eruptions in beard follicles, but was unsuccessful. Moving on to ophthalmia neonatorum, a gonococcal infection in infants, he achieved the first recorded cure with penicillin, on November 25, 1930. He then cured four additional patients (one adult and three infants) of eye infections, but failed to cure

Context: Document [6](Title: Gladys Lounsbury Hobby) 1940 and 1941, before presenting at the American Society for Clinical Investigation. They discovered that penicillin was a powerful germ-killer that reduced the severity of infectious diseases and made procedures such as organ transplantation and open-heart surgery possible. Their findings received media coverage, which helped attract funding from the United States Government to mass-produce penicillin during World War II, saving the lives of many soldiers. At Pfizer, Hobby did extensive early work on Terramycin and Viomycin, used for the treatment of tuberculosis. Gladys Lounsbury Hobby Gladys Lounsbury Hobby (November 19, 1910 – July 4, 1993), born in New York City,

Context: Document [7](Title: Penicillin) by scientists and physicians on the antibacterial properties of the different types of moulds including the mould penicillium but they were unable to discern what process was causing the effect. The effects of penicillium mould would finally be isolated in 1928 by Scottish scientist Alexander Fleming, in work that seems to have been independent of those earlier observations. Fleming recounted that the date of his discovery of penicillin was on the morning of Friday 28 September 1928. The traditional version of this story describes the discovery as a serendipitous accident: in his laboratory in the basement of St Mary's Hospital

Context: Document [8](Title: Penicillin) November 19, 1999. In 1930, Cecil George Paine, a pathologist at the Royal Infirmary in Sheffield, attempted to use penicillin to treat sycosis barbae, eruptions in beard follicles, but was unsuccessful. Moving on to ophthalmia neonatorum, a gonococcal infection in infants, he achieved the first recorded cure with penicillin, on November 25, 1930. He then cured four additional patients (one adult and three infants) of eye infections, and failed to cure a fifth. In 1939, Australian scientist Howard Florey (later Baron Florey) and a team of researchers (Ernst Boris Chain, Edward Abraham, Arthur Duncan Gardner, Norman Heatley, M. Jennings, J.

Context: Document [9](Title: Albert Alexander (police officer)) murder, the purification invites disaster.” Nonetheless, by March 15, 1945, supplies of penicillin were not only available to American troops, but to the American public, as war-time restrictions on availability were lifted. Albert Alexander (police officer) Reserve Constable Albert Alexander (1896 – 15 March 1941) was the first patient to be treated with injections of penicillin. Albert Alexander was a constable in the police force of the County of Oxford, England. In December 1940, Constable Alexander was accidentally scratched by a rose thorn on his face. By the end of the month, the scratch was badly infected with both "Staphylococcus"

Context: Document [10](Title: Penicillin) Penicillin was discovered in 1928 by Scottish scientist Alexander Fleming. People began using it to treat infections in 1942. There are several enhanced penicillin families which are effective against additional bacteria; these include the antistaphylococcal penicillins, aminopenicillins and the antipseudomonal penicillins. They are derived from Penicillium fungi.

Context: Document [11](Title: La Follette-Bulwinkle Act) Cosmetic Act Penicillin Amendment on July 6, 1945. The United States public law required the U.S. Food and Drug Administration to certify and test penicillin samplings validating the effectiveness, potency, purification, and safety of the antibiotic drugs. The 1960s sexual revolution movement prompt the United States Congress to draft amendments for the Public Health Service Act authorizing control, prevention, and vaccination assistance for communicable diseases. The United States statutes were enacted into law by the 37th President of the United States Richard Nixon and the 38th President of the United States Gerald Ford. By 1914, American exploitation films were produced

Context: Document [12](Title: History of penicillin) earnest in the 1870s, in the United Kingdom. Sir John Scott Burdon-Sanderson, who started out at St. Mary's Hospital (1852–1858) and later worked there as a lecturer (1854–1862), observed that culture fluid covered with mold would produce no bacterial growth. Burdon-Sanderson's discovery prompted Joseph Lister, an English surgeon and the father of modern antisepsis, to discover in 1871 that urine samples contaminated with mold also did not permit the growth of bacteria. Lister also described the antibacterial action on human tissue of a species of mold he called "Penicillium glaucum". A nurse at King's College Hospital whose wounds did not

Context: Document [13](Title: Martin Henry Dawson) prepare it and use it in human disease. This included the successful treatment of bacterial endocarditis with penicillin, and the use of gold salts in the treatment of rheumatoid arthritis. Dawson became the first person in history to stick a needle full of an antibiotic (penicillin) into a patient, on October 16, 1940. After he had graduated Dalhousie University in Halifax with a BA in 1916 he started serving in the Canadian forces in the First World War. Pte. M. Henry Dawson was with No. 7 Stationary Hospital at La Harve, France. He became a Capt. in the Nova Scotia

Context: Document [14](Title: Vincenzo Tiberio) connection anticipated the discovery of the drug penicillin by Alexander Fleming thirty-five years later (see: Penicillin - Discovery). At the time, his work was disregarded as coincidence and received no further study. Vincenzo Tiberio Vincenzo Tiberio (May 1, 1869 – January 7, 1915) was an Italian researcher and medical officer of the Medical Corps of the Italian Navy and physician at the University of Naples. During his medical studies at the Faculty of Medicine in Naples he noticed that when the walls of a well which supplied drinking water was cleaned off, the people who drank the well’s water complained

Context: Document [15](Title: Penicillium chrysogenum) a fermenter. The mold is grown in a liquid culture containing sugar and other nutrients including a source of nitrogen. As the mold grows, it uses up the sugar and starts to make penicillin only after using up most of the nutrients for growth. Penicillin was discovered in 1928 when Alexander Fleming's lab assistant accidentally left a window open overnight and mold spores covered his "Staphylococcus" bacterial specimens in a Petri dish. At first, Fleming was very irritated at the contamination, but as he was about to throw the specimens away, he noticed something interesting. He looked under the microscope

Context: Document [16](Title: Biotechnology) – to form what we today know as penicillin. In 1940, penicillin became available for medicinal use to treat bacterial infections in humans. The field of modern biotechnology is generally thought of as having been born in 1971 when Paul Berg's (Stanford) experiments in gene splicing had early success. Herbert W. Boyer (Univ. Calif. at San Francisco) and Stanley N. Cohen (Stanford) significantly advanced the new technology in 1972 by transferring genetic material into a bacterium, such that the imported material would be reproduced. The commercial viability of a biotechnology industry was significantly expanded on June 16, 1980, when the

Context: Document [17](Title: Norman Heatley) to a PhD in 1936, and he then moved to Oxford where he became a fellow of Lincoln College at the University of Oxford and joined a team working under Howard Florey, which also included Ernst Chain. Alexander Fleming had first discovered penicillin by accident in 1928, but at that time believed it had little application. When Florey and his team recognised the potential of the discovery for combating bacterial infection, they faced the problem of how to manufacture penicillin in sufficient quantities to be of use. Heatley, although the junior member of the team, possessed a natural gift for

Context: Document [18](Title: History of penicillin) and subsequently concentrated what he later named "penicillin". During the next twelve years, Fleming grew and distributed the original mold, which was eventually identified as "Penicillium notatum" (now known as "Penicillium chrysogenum"). He was unsuccessful in making a stable form of it for mass production. Cecil George Paine, a pathologist at the Royal Infirmary in Sheffield, attempted to treat sycosis (eruptions in beard follicles) with penicillin but was unsuccessful, probably because the drug did not penetrate deep enough. Moving on to ophthalmia neonatorum, a gonococcal infection in babies, he achieved the first cure on 25 November 1930. He cured four

Context: Document [19](Title: History of penicillin) patients (one adult, the others infants) of eye infections, although a fifth patient was not so lucky. At Oxford, Howard Walter Florey organized a large and very skilled biochemical research team, notable among them Ernst Boris Chain and Norman Heatley, to undertake clinical trials and produce a stable penicillin in quantity. In 1940, Chain and Edward Abraham reported the first indication of antibiotic resistance to penicillin, an "E. coli" strain that produced the penicillinase enzyme, which was capable of breaking down penicillin and completely negating its antibacterial effect. Between 1941 and 1943, Moyer, Coghill and Raper at the USDA Northern

Context: Document [20](Title: Grünenthal) prohibited the research and manufacture of penicillin by German companies. When the ban was lifted, Grünenthal was the first company to introduce penicillin in the postwar period into the German market. This investment achieved a big financial boost for the company. Chemie Grünenthal synthesized thalidomide in 1954 and acquired a 20-year patent. Soon after obtaining a patent in April 1954, the company started clinical trials, and as early as November 1956, marketed the drug for the treatment of respiratory infections under the trade name Grippex, a combination drug that contained thalidomide, quinine, vitamin C, phenacetin, and acetylsalicylic acid. Researchers at

Question: when was penicillin first introduced to the public?

Answer: After World War II

Answer: 1942


Context: Document [1](Title: History of penicillin) respond to any traditional antiseptic was then given another substance that cured her, and Lister's registrar informed her that it was called Penicillium. In 1874, the Welsh physician William Roberts, who later coined the term "enzyme", observed that bacterial contamination is generally absent in laboratory cultures of "Penicillium glaucum". John Tyndall followed up on Burdon-Sanderson's work and demonstrated to the Royal Society in 1875 the antibacterial action of the "Penicillium" fungus. By this time, "Bacillus anthracis" had been shown to cause anthrax, the first demonstration that a specific bacterium caused a specific disease. In 1877, French biologists Louis Pasteur and

Context: Document [2](Title: History of penicillin) (now Sandoz) developed the first acid-stable penicillin for oral administration, Penicillin V. American chemist John C. Sheehan of the Massachusetts Institute of Technology (MIT) subsequently completed the first chemical synthesis of penicillin in 1957. The second-generation semi-synthetic β-lactam antibiotic methicillin, designed to counter first-generation-resistant penicillinases, was introduced in the United Kingdom in 1959. Methicillin-resistant forms of "Staphylococcus aureus" likely already existed at the time. History of penicillin The history of penicillin follows a number of observations and discoveries of apparent evidence of antibiotic activity in molds before the modern isolation of the chemical penicillin in 1928. There are anecdotes about

Context: Document [3](Title: History of penicillin) History of penicillin The history of penicillin follows a number of observations and discoveries of apparent evidence of antibiotic activity in molds before the modern isolation of the chemical penicillin in 1928. There are anecdotes about ancient societies using molds to treat infections, and in the following centuries many people observed the inhibition of bacterial growth by various molds. However, it is unknown if the species involved were "Penicillium" species or if the antimicrobial substances produced were penicillin. The Scottish physician Alexander Fleming was the first to suggest that a "Penicillium" mold must secrete an antibacterial substance, and the first

Context: Document [4](Title: History of penicillin) to concentrate the active substance involved, which he named penicillin, in 1928. Penicillin was the first modern antibiotic. During the next twelve years Fleming grew, distributed, and studied the original mold, which was determined to be a rare variant of "Penicillium notatum" (now "Penicillium chrysogenum"). Many later scientists were involved in the stabilization and mass production of penicillin and in the search for more productive strains of "Penicillium". Important contributors include Ernst Chain, Howard Florey, Norman Heatley, and Edward Abraham. Shortly after the discovery of penicillin, scientists found that some disease-causing pathogens display antibiotic resistance to penicillin. Research that aims

Context: Document [5](Title: Roaring Twenties) Alexander Fleming discovered a substance that killed a number of disease-causing bacteria. In 1929, he named the new substance "penicillin". His publications were largely ignored at first, but it became a significant antibiotic in the 1930s. In 1930, Cecil George Paine, a pathologist at Sheffield Royal Infirmary, used penicillin to treat sycosis barbae, eruptions in beard follicles, but was unsuccessful. Moving on to ophthalmia neonatorum, a gonococcal infection in infants, he achieved the first recorded cure with penicillin, on November 25, 1930. He then cured four additional patients (one adult and three infants) of eye infections, but failed to cure

Context: Document [6](Title: Gladys Lounsbury Hobby) 1940 and 1941, before presenting at the American Society for Clinical Investigation. They discovered that penicillin was a powerful germ-killer that reduced the severity of infectious diseases and made procedures such as organ transplantation and open-heart surgery possible. Their findings received media coverage, which helped attract funding from the United States Government to mass-produce penicillin during World War II, saving the lives of many soldiers. At Pfizer, Hobby did extensive early work on Terramycin and Viomycin, used for the treatment of tuberculosis. Gladys Lounsbury Hobby Gladys Lounsbury Hobby (November 19, 1910 – July 4, 1993), born in New York City,

Context: Document [7](Title: Penicillin) by scientists and physicians on the antibacterial properties of the different types of moulds including the mould penicillium but they were unable to discern what process was causing the effect. The effects of penicillium mould would finally be isolated in 1928 by Scottish scientist Alexander Fleming, in work that seems to have been independent of those earlier observations. Fleming recounted that the date of his discovery of penicillin was on the morning of Friday 28 September 1928. The traditional version of this story describes the discovery as a serendipitous accident: in his laboratory in the basement of St Mary's Hospital

Context: Document [8](Title: Penicillin) November 19, 1999. In 1930, Cecil George Paine, a pathologist at the Royal Infirmary in Sheffield, attempted to use penicillin to treat sycosis barbae, eruptions in beard follicles, but was unsuccessful. Moving on to ophthalmia neonatorum, a gonococcal infection in infants, he achieved the first recorded cure with penicillin, on November 25, 1930. He then cured four additional patients (one adult and three infants) of eye infections, and failed to cure a fifth. In 1939, Australian scientist Howard Florey (later Baron Florey) and a team of researchers (Ernst Boris Chain, Edward Abraham, Arthur Duncan Gardner, Norman Heatley, M. Jennings, J.

Context: Document [9](Title: Albert Alexander (police officer)) murder, the purification invites disaster.” Nonetheless, by March 15, 1945, supplies of penicillin were not only available to American troops, but to the American public, as war-time restrictions on availability were lifted. Albert Alexander (police officer) Reserve Constable Albert Alexander (1896 – 15 March 1941) was the first patient to be treated with injections of penicillin. Albert Alexander was a constable in the police force of the County of Oxford, England. In December 1940, Constable Alexander was accidentally scratched by a rose thorn on his face. By the end of the month, the scratch was badly infected with both "Staphylococcus"

Context: Document [10](Title: La Follette-Bulwinkle Act) Cosmetic Act Penicillin Amendment on July 6, 1945. The United States public law required the U.S. Food and Drug Administration to certify and test penicillin samplings validating the effectiveness, potency, purification, and safety of the antibiotic drugs. The 1960s sexual revolution movement prompt the United States Congress to draft amendments for the Public Health Service Act authorizing control, prevention, and vaccination assistance for communicable diseases. The United States statutes were enacted into law by the 37th President of the United States Richard Nixon and the 38th President of the United States Gerald Ford. By 1914, American exploitation films were produced

Context: Document [11](Title: History of penicillin) earnest in the 1870s, in the United Kingdom. Sir John Scott Burdon-Sanderson, who started out at St. Mary's Hospital (1852–1858) and later worked there as a lecturer (1854–1862), observed that culture fluid covered with mold would produce no bacterial growth. Burdon-Sanderson's discovery prompted Joseph Lister, an English surgeon and the father of modern antisepsis, to discover in 1871 that urine samples contaminated with mold also did not permit the growth of bacteria. Lister also described the antibacterial action on human tissue of a species of mold he called "Penicillium glaucum". A nurse at King's College Hospital whose wounds did not

Context: Document [12](Title: Martin Henry Dawson) prepare it and use it in human disease. This included the successful treatment of bacterial endocarditis with penicillin, and the use of gold salts in the treatment of rheumatoid arthritis. Dawson became the first person in history to stick a needle full of an antibiotic (penicillin) into a patient, on October 16, 1940. After he had graduated Dalhousie University in Halifax with a BA in 1916 he started serving in the Canadian forces in the First World War. Pte. M. Henry Dawson was with No. 7 Stationary Hospital at La Harve, France. He became a Capt. in the Nova Scotia

Context: Document [13](Title: Vincenzo Tiberio) connection anticipated the discovery of the drug penicillin by Alexander Fleming thirty-five years later (see: Penicillin - Discovery). At the time, his work was disregarded as coincidence and received no further study. Vincenzo Tiberio Vincenzo Tiberio (May 1, 1869 – January 7, 1915) was an Italian researcher and medical officer of the Medical Corps of the Italian Navy and physician at the University of Naples. During his medical studies at the Faculty of Medicine in Naples he noticed that when the walls of a well which supplied drinking water was cleaned off, the people who drank the well’s water complained

Context: Document [14](Title: Penicillium chrysogenum) a fermenter. The mold is grown in a liquid culture containing sugar and other nutrients including a source of nitrogen. As the mold grows, it uses up the sugar and starts to make penicillin only after using up most of the nutrients for growth. Penicillin was discovered in 1928 when Alexander Fleming's lab assistant accidentally left a window open overnight and mold spores covered his "Staphylococcus" bacterial specimens in a Petri dish. At first, Fleming was very irritated at the contamination, but as he was about to throw the specimens away, he noticed something interesting. He looked under the microscope

Context: Document [15](Title: Penicillin) Penicillin was discovered in 1928 by Scottish scientist Alexander Fleming. People began using it to treat infections in 1942. There are several enhanced penicillin families which are effective against additional bacteria; these include the antistaphylococcal penicillins, aminopenicillins and the antipseudomonal penicillins. They are derived from Penicillium fungi.

Context: Document [16](Title: Biotechnology) – to form what we today know as penicillin. In 1940, penicillin became available for medicinal use to treat bacterial infections in humans. The field of modern biotechnology is generally thought of as having been born in 1971 when Paul Berg's (Stanford) experiments in gene splicing had early success. Herbert W. Boyer (Univ. Calif. at San Francisco) and Stanley N. Cohen (Stanford) significantly advanced the new technology in 1972 by transferring genetic material into a bacterium, such that the imported material would be reproduced. The commercial viability of a biotechnology industry was significantly expanded on June 16, 1980, when the

Context: Document [17](Title: Norman Heatley) to a PhD in 1936, and he then moved to Oxford where he became a fellow of Lincoln College at the University of Oxford and joined a team working under Howard Florey, which also included Ernst Chain. Alexander Fleming had first discovered penicillin by accident in 1928, but at that time believed it had little application. When Florey and his team recognised the potential of the discovery for combating bacterial infection, they faced the problem of how to manufacture penicillin in sufficient quantities to be of use. Heatley, although the junior member of the team, possessed a natural gift for

Context: Document [18](Title: History of penicillin) and subsequently concentrated what he later named "penicillin". During the next twelve years, Fleming grew and distributed the original mold, which was eventually identified as "Penicillium notatum" (now known as "Penicillium chrysogenum"). He was unsuccessful in making a stable form of it for mass production. Cecil George Paine, a pathologist at the Royal Infirmary in Sheffield, attempted to treat sycosis (eruptions in beard follicles) with penicillin but was unsuccessful, probably because the drug did not penetrate deep enough. Moving on to ophthalmia neonatorum, a gonococcal infection in babies, he achieved the first cure on 25 November 1930. He cured four

Context: Document [19](Title: History of penicillin) patients (one adult, the others infants) of eye infections, although a fifth patient was not so lucky. At Oxford, Howard Walter Florey organized a large and very skilled biochemical research team, notable among them Ernst Boris Chain and Norman Heatley, to undertake clinical trials and produce a stable penicillin in quantity. In 1940, Chain and Edward Abraham reported the first indication of antibiotic resistance to penicillin, an "E. coli" strain that produced the penicillinase enzyme, which was capable of breaking down penicillin and completely negating its antibacterial effect. Between 1941 and 1943, Moyer, Coghill and Raper at the USDA Northern

Context: Document [20](Title: Grünenthal) prohibited the research and manufacture of penicillin by German companies. When the ban was lifted, Grünenthal was the first company to introduce penicillin in the postwar period into the German market. This investment achieved a big financial boost for the company. Chemie Grünenthal synthesized thalidomide in 1954 and acquired a 20-year patent. Soon after obtaining a patent in April 1954, the company started clinical trials, and as early as November 1956, marketed the drug for the treatment of respiratory infections under the trade name Grippex, a combination drug that contained thalidomide, quinine, vitamin C, phenacetin, and acetylsalicylic acid. Researchers at

Question: when was penicillin first introduced to the public?

Answer: After World War II

Answer: 1942


Context: Document [1](Title: History of penicillin) respond to any traditional antiseptic was then given another substance that cured her, and Lister's registrar informed her that it was called Penicillium. In 1874, the Welsh physician William Roberts, who later coined the term "enzyme", observed that bacterial contamination is generally absent in laboratory cultures of "Penicillium glaucum". John Tyndall followed up on Burdon-Sanderson's work and demonstrated to the Royal Society in 1875 the antibacterial action of the "Penicillium" fungus. By this time, "Bacillus anthracis" had been shown to cause anthrax, the first demonstration that a specific bacterium caused a specific disease. In 1877, French biologists Louis Pasteur and

Context: Document [2](Title: History of penicillin) (now Sandoz) developed the first acid-stable penicillin for oral administration, Penicillin V. American chemist John C. Sheehan of the Massachusetts Institute of Technology (MIT) subsequently completed the first chemical synthesis of penicillin in 1957. The second-generation semi-synthetic β-lactam antibiotic methicillin, designed to counter first-generation-resistant penicillinases, was introduced in the United Kingdom in 1959. Methicillin-resistant forms of "Staphylococcus aureus" likely already existed at the time. History of penicillin The history of penicillin follows a number of observations and discoveries of apparent evidence of antibiotic activity in molds before the modern isolation of the chemical penicillin in 1928. There are anecdotes about

Context: Document [3](Title: History of penicillin) History of penicillin The history of penicillin follows a number of observations and discoveries of apparent evidence of antibiotic activity in molds before the modern isolation of the chemical penicillin in 1928. There are anecdotes about ancient societies using molds to treat infections, and in the following centuries many people observed the inhibition of bacterial growth by various molds. However, it is unknown if the species involved were "Penicillium" species or if the antimicrobial substances produced were penicillin. The Scottish physician Alexander Fleming was the first to suggest that a "Penicillium" mold must secrete an antibacterial substance, and the first

Context: Document [4](Title: History of penicillin) to concentrate the active substance involved, which he named penicillin, in 1928. Penicillin was the first modern antibiotic. During the next twelve years Fleming grew, distributed, and studied the original mold, which was determined to be a rare variant of "Penicillium notatum" (now "Penicillium chrysogenum"). Many later scientists were involved in the stabilization and mass production of penicillin and in the search for more productive strains of "Penicillium". Important contributors include Ernst Chain, Howard Florey, Norman Heatley, and Edward Abraham. Shortly after the discovery of penicillin, scientists found that some disease-causing pathogens display antibiotic resistance to penicillin. Research that aims

Context: Document [5](Title: Roaring Twenties) Alexander Fleming discovered a substance that killed a number of disease-causing bacteria. In 1929, he named the new substance "penicillin". His publications were largely ignored at first, but it became a significant antibiotic in the 1930s. In 1930, Cecil George Paine, a pathologist at Sheffield Royal Infirmary, used penicillin to treat sycosis barbae, eruptions in beard follicles, but was unsuccessful. Moving on to ophthalmia neonatorum, a gonococcal infection in infants, he achieved the first recorded cure with penicillin, on November 25, 1930. He then cured four additional patients (one adult and three infants) of eye infections, but failed to cure

Context: Document [6](Title: Gladys Lounsbury Hobby) 1940 and 1941, before presenting at the American Society for Clinical Investigation. They discovered that penicillin was a powerful germ-killer that reduced the severity of infectious diseases and made procedures such as organ transplantation and open-heart surgery possible. Their findings received media coverage, which helped attract funding from the United States Government to mass-produce penicillin during World War II, saving the lives of many soldiers. At Pfizer, Hobby did extensive early work on Terramycin and Viomycin, used for the treatment of tuberculosis. Gladys Lounsbury Hobby Gladys Lounsbury Hobby (November 19, 1910 – July 4, 1993), born in New York City,

Context: Document [7](Title: Penicillin) by scientists and physicians on the antibacterial properties of the different types of moulds including the mould penicillium but they were unable to discern what process was causing the effect. The effects of penicillium mould would finally be isolated in 1928 by Scottish scientist Alexander Fleming, in work that seems to have been independent of those earlier observations. Fleming recounted that the date of his discovery of penicillin was on the morning of Friday 28 September 1928. The traditional version of this story describes the discovery as a serendipitous accident: in his laboratory in the basement of St Mary's Hospital

Context: Document [8](Title: Penicillin) November 19, 1999. In 1930, Cecil George Paine, a pathologist at the Royal Infirmary in Sheffield, attempted to use penicillin to treat sycosis barbae, eruptions in beard follicles, but was unsuccessful. Moving on to ophthalmia neonatorum, a gonococcal infection in infants, he achieved the first recorded cure with penicillin, on November 25, 1930. He then cured four additional patients (one adult and three infants) of eye infections, and failed to cure a fifth. In 1939, Australian scientist Howard Florey (later Baron Florey) and a team of researchers (Ernst Boris Chain, Edward Abraham, Arthur Duncan Gardner, Norman Heatley, M. Jennings, J.

Context: Document [9](Title: Albert Alexander (police officer)) murder, the purification invites disaster.” Nonetheless, by March 15, 1945, supplies of penicillin were not only available to American troops, but to the American public, as war-time restrictions on availability were lifted. Albert Alexander (police officer) Reserve Constable Albert Alexander (1896 – 15 March 1941) was the first patient to be treated with injections of penicillin. Albert Alexander was a constable in the police force of the County of Oxford, England. In December 1940, Constable Alexander was accidentally scratched by a rose thorn on his face. By the end of the month, the scratch was badly infected with both "Staphylococcus"

Context: Document [10](Title: La Follette-Bulwinkle Act) Cosmetic Act Penicillin Amendment on July 6, 1945. The United States public law required the U.S. Food and Drug Administration to certify and test penicillin samplings validating the effectiveness, potency, purification, and safety of the antibiotic drugs. The 1960s sexual revolution movement prompt the United States Congress to draft amendments for the Public Health Service Act authorizing control, prevention, and vaccination assistance for communicable diseases. The United States statutes were enacted into law by the 37th President of the United States Richard Nixon and the 38th President of the United States Gerald Ford. By 1914, American exploitation films were produced

Context: Document [11](Title: History of penicillin) earnest in the 1870s, in the United Kingdom. Sir John Scott Burdon-Sanderson, who started out at St. Mary's Hospital (1852–1858) and later worked there as a lecturer (1854–1862), observed that culture fluid covered with mold would produce no bacterial growth. Burdon-Sanderson's discovery prompted Joseph Lister, an English surgeon and the father of modern antisepsis, to discover in 1871 that urine samples contaminated with mold also did not permit the growth of bacteria. Lister also described the antibacterial action on human tissue of a species of mold he called "Penicillium glaucum". A nurse at King's College Hospital whose wounds did not

Context: Document [12](Title: Martin Henry Dawson) prepare it and use it in human disease. This included the successful treatment of bacterial endocarditis with penicillin, and the use of gold salts in the treatment of rheumatoid arthritis. Dawson became the first person in history to stick a needle full of an antibiotic (penicillin) into a patient, on October 16, 1940. After he had graduated Dalhousie University in Halifax with a BA in 1916 he started serving in the Canadian forces in the First World War. Pte. M. Henry Dawson was with No. 7 Stationary Hospital at La Harve, France. He became a Capt. in the Nova Scotia

Context: Document [13](Title: Vincenzo Tiberio) connection anticipated the discovery of the drug penicillin by Alexander Fleming thirty-five years later (see: Penicillin - Discovery). At the time, his work was disregarded as coincidence and received no further study. Vincenzo Tiberio Vincenzo Tiberio (May 1, 1869 – January 7, 1915) was an Italian researcher and medical officer of the Medical Corps of the Italian Navy and physician at the University of Naples. During his medical studies at the Faculty of Medicine in Naples he noticed that when the walls of a well which supplied drinking water was cleaned off, the people who drank the well’s water complained

Context: Document [14](Title: Penicillium chrysogenum) a fermenter. The mold is grown in a liquid culture containing sugar and other nutrients including a source of nitrogen. As the mold grows, it uses up the sugar and starts to make penicillin only after using up most of the nutrients for growth. Penicillin was discovered in 1928 when Alexander Fleming's lab assistant accidentally left a window open overnight and mold spores covered his "Staphylococcus" bacterial specimens in a Petri dish. At first, Fleming was very irritated at the contamination, but as he was about to throw the specimens away, he noticed something interesting. He looked under the microscope

Context: Document [15](Title: Biotechnology) – to form what we today know as penicillin. In 1940, penicillin became available for medicinal use to treat bacterial infections in humans. The field of modern biotechnology is generally thought of as having been born in 1971 when Paul Berg's (Stanford) experiments in gene splicing had early success. Herbert W. Boyer (Univ. Calif. at San Francisco) and Stanley N. Cohen (Stanford) significantly advanced the new technology in 1972 by transferring genetic material into a bacterium, such that the imported material would be reproduced. The commercial viability of a biotechnology industry was significantly expanded on June 16, 1980, when the

Context: Document [16](Title: Norman Heatley) to a PhD in 1936, and he then moved to Oxford where he became a fellow of Lincoln College at the University of Oxford and joined a team working under Howard Florey, which also included Ernst Chain. Alexander Fleming had first discovered penicillin by accident in 1928, but at that time believed it had little application. When Florey and his team recognised the potential of the discovery for combating bacterial infection, they faced the problem of how to manufacture penicillin in sufficient quantities to be of use. Heatley, although the junior member of the team, possessed a natural gift for

Context: Document [17](Title: History of penicillin) and subsequently concentrated what he later named "penicillin". During the next twelve years, Fleming grew and distributed the original mold, which was eventually identified as "Penicillium notatum" (now known as "Penicillium chrysogenum"). He was unsuccessful in making a stable form of it for mass production. Cecil George Paine, a pathologist at the Royal Infirmary in Sheffield, attempted to treat sycosis (eruptions in beard follicles) with penicillin but was unsuccessful, probably because the drug did not penetrate deep enough. Moving on to ophthalmia neonatorum, a gonococcal infection in babies, he achieved the first cure on 25 November 1930. He cured four

Context: Document [18](Title: History of penicillin) patients (one adult, the others infants) of eye infections, although a fifth patient was not so lucky. At Oxford, Howard Walter Florey organized a large and very skilled biochemical research team, notable among them Ernst Boris Chain and Norman Heatley, to undertake clinical trials and produce a stable penicillin in quantity. In 1940, Chain and Edward Abraham reported the first indication of antibiotic resistance to penicillin, an "E. coli" strain that produced the penicillinase enzyme, which was capable of breaking down penicillin and completely negating its antibacterial effect. Between 1941 and 1943, Moyer, Coghill and Raper at the USDA Northern

Context: Document [19](Title: Grünenthal) prohibited the research and manufacture of penicillin by German companies. When the ban was lifted, Grünenthal was the first company to introduce penicillin in the postwar period into the German market. This investment achieved a big financial boost for the company. Chemie Grünenthal synthesized thalidomide in 1954 and acquired a 20-year patent. Soon after obtaining a patent in April 1954, the company started clinical trials, and as early as November 1956, marketed the drug for the treatment of respiratory infections under the trade name Grippex, a combination drug that contained thalidomide, quinine, vitamin C, phenacetin, and acetylsalicylic acid. Researchers at

Context: Document [20](Title: Penicillin) Penicillin was discovered in 1928 by Scottish scientist Alexander Fleming. People began using it to treat infections in 1942. There are several enhanced penicillin families which are effective against additional bacteria; these include the antistaphylococcal penicillins, aminopenicillins and the antipseudomonal penicillins. They are derived from Penicillium fungi.

Question: when was penicillin first introduced to the public?

Answer: After World War II

Answer: 1942


Context: Document [1](Title: IP Multimedia Subsystem) To ease the integration with the Internet, IMS uses IETF protocols wherever possible, e.g., SIP (Session Initiation Protocol). According to the 3GPP, IMS is not intended to standardize applications, but rather to aid the access of multimedia and voice applications from wireless and wireline terminals, i.e., to create a form of fixed-mobile convergence (FMC). This is done by having a horizontal control layer that isolates the access network from the service layer. From a logical architecture perspective, services need not have their own control functions, as the control layer is a common horizontal layer. However, in implementation this does not

Context: Document [2](Title: Session Initiation Protocol) permanent element of the IP Multimedia Subsystem (IMS) architecture for IP-based streaming multimedia services in cellular networks. In June 2002 the specification was revised in and various extensions and clarifications have been published since. SIP was designed to provide a signaling and call setup protocol for IP-based communications supporting the call processing functions and features present in the public switched telephone network (PSTN) with a vision of supporting new multimedia applications. It has been extended for video conferencing, streaming media distribution, instant messaging, presence information, file transfer, Internet fax and online games. SIP is distinguished by its proponents for having

Context: Document [3](Title: UMTS security) calls, video conferences, streaming and chat. SIP is specified by the Internet Engineering Task Force (IETF)27. IMS also uses the IETF Session Description Protocol (SDP)28 to specify the session parameters and to negotiate the codecs to be used. SIP runs on top of different IP transport protocols such as the User Datagram Protocol (UDP) and the Transmission Control Protocol (TCP). A 3G IMS subscriber has one IP multimedia private identity (IMPI) and at least one IP multimedia public identity (IMPU). To participate in multimedia sessions, an IMS subscriber must register at least one IMPU with the IMS. The private identity

Context: Document [4](Title: SIP extensions for the IP Multimedia Subsystem) extensions is not restricted to the IMS framework. The 3GPP has stated several general requirements stated for operation of the IMS. These include an efficient use of the radio interface by minimizing the exchange of signaling messages between the mobile terminal and the network, a minimum session setup time by performing tasks prior to session establishment instead of during session establishment, a minimum support required in the terminal, the support for roaming and non-roaming scenarios with terminal mobility management (supported by the access network, not SIP), and support for IPv6 addressing. Other requirements involve protocol extensions, such as SIP header

Context: Document [5](Title: SIP extensions for the IP Multimedia Subsystem) functionality. These extensions are based on Request for Comments (RFC) protocol recommendations by the IETF. The 3GPP, which is a collaboration between groups of telecommunications associations aimed at developing and maintaining the IMS, stated a series of requirements for SIP to be successfully used in the IMS. Some of them could be addressed by using existing capabilities and extensions in SIP while, in other cases, the 3GPP had to collaborate with the IETF to standardize new SIP extensions to meet the new requirements. In any case, the IETF evolves SIP in a generic basis, so that the use of its

Context: Document [6](Title: SIP extensions for the IP Multimedia Subsystem) configured to relay messages across both networks according to these recommendations, user agents will need to implement extensions so that they can directly exchange media streams. These extensions are related to the Session Description Protocol offer/answer initial exchange, that will be used to gather the IPv4 and IPv6 addresses of both ends so that they can establish a direct communication. Apart from all the explained extensions to SIP that make it possible for the IMS to work successfully, it is also necessary that the IMS framework interworks and exchanges services with existing network infrastructures, mainly the Public switched telephone network

Context: Document [7](Title: SIP extensions for the IP Multimedia Subsystem) to negotiate and allocate the call resources before the called party is alerted. In the IMS framework, it is required that once the callee is alerted, the chances of a session failure are minimum. An important source of failure is the inability to reserve network resources to support the session, so these resources should be allocated before the phone rings. However, in the IMS, to reserve resources the network needs to know the callee's IP address, port and session parameters and therefore it is necessary that the initial offer/answer exchange to establish a session has started (INVITE request). In basic

Context: Document [8](Title: SIP extensions for the IP Multimedia Subsystem) resource reservation on its side. Subsequent UPDATE requests are sent to inform about the reservation progress, and they are answered by 2XX response codes. In a typical offer/answer exchange, one UPDATE will be sent by the calling party when its reservation is completed, then the called party will respond and eventually finish allocating the resources. It is then, when all the resources for the call are in place, when the caller is alerted. In the IMS framework it is fundamental to handle user identities for authentication, authorization and accounting purposes. The IMS is meant to provide multimedia services over IP

Context: Document [9](Title: SIP trunking) applications such as desktop sharing, web conferencing, and shared whiteboard. The architecture of SIP trunking provides a partitioning of the unified communications network into two different domains of expertise: The interconnection between the two domains must occur through a SIP trunk. The interconnection between the two domains, created by transport via the Internet Protocol (IP), involves setting specific rules and regulations as well as the ability to handle some services and protocols that fall under the name of SIP trunking. The ITSP is responsible to the applicable regulatory authority regarding all the following law obligations of the public domain: The

Context: Document [10](Title: Telecoms & Internet converged Services & Protocols for Advanced Networks) networking. In 2011, TISPAN published the specification of a functional architecture for Content Delivery Networks (CDN) and is now working on the specification of the protocols applicable to the reference points identified in this architecture (See ETSI TS 182 019) The ETSI website on Next Generation Networking states: ""Standards for fixed NGN were developed by the now closed ETSI technical committee TISPAN. The TC has adopted the 3GPP™ core IMS specifications using Internet (SIP) protocols to allow features such as Presence, IPTV, Messaging, and Conferencing to be delivered irrespective of the network in use. Maintenance of NGN standards are now

Context: Document [11](Title: SIP extensions for the IP Multimedia Subsystem) a format used to describe streaming media initialization parameters, carried in the body of SIP messages. The new SDP attributes are meant to describe the "current status" of the resource reservation, the "desired status" of the reservation to proceed with session establishment, and the "confirmation status", to indicate when the reservation status should be confirmed. In the IMS, the initial session parameter negotiation can be done by using the provisional responses and session description updating extensions, along with SDP in the body of the messages. The first offer, described by means of SDP, can be carried by the INVITE request

Context: Document [12](Title: IP Multimedia Subsystem) in a single network, for dimensioning, load balancing or organizational issues. The user can connect to IMS in various ways, most of which use the standard IP. IMS terminals (such as mobile phones, personal digital assistants (PDAs) and computers) can register directly on IMS, even when they are roaming in another network or country (the visited network). The only requirement is that they can use IP and run SIP user agents. Fixed access (e.g., Digital Subscriber Line (DSL), cable modems, Ethernet), mobile access (e.g. W-CDMA, CDMA2000, GSM, GPRS) and wireless access (e.g., WLAN, WiMAX) are all supported. Other phone systems

Context: Document [13](Title: SIP extensions for the IP Multimedia Subsystem) to the user agent. This extension is only applicable within administrative domains with trust relationships. It was particularly designed for specialized SIP networks like the IMS, and not for the general Internet. Source routing is the mechanism that allows the sender of a message to specify partially or completely the route the message traverses. In SIP, the "route" header field, filled by the sender, supports this functionality by listing a set of proxies the message will visit. In the IMS context, there are certain network entities (i.e. certain CSCFs) that must be traversed by requests from or to a user,

Context: Document [14](Title: Telecoms & Internet converged Services & Protocols for Advanced Networks) it ensures mobility of users, terminals and services as much as possible, even across administrative boundaries. A key subsystem is based on the architectures of 3rd Generation Partnership Project (3GPP) IP Multimedia Subsystem (IMS). TISPAN has been working with 3GPP to extend the IMS architecture with capabilities required in support of wire-line access. TISPAN NGN Release 2 was finalized early 2008, and added support for IPTV services and Business Communications over the IMS. Since early 2008, TISPAN has begun work on the third release of its NGN specifications with prime focus on IPTV enhancements, Content Delivery Networks (CDN) and home

Context: Document [15](Title: SIP extensions for the IP Multimedia Subsystem) SIP instance, and the registrar (i.e. S-CSCF) builds the GRUU, associates it to the registered identity and SIP instance and sends it back to the user agent in the response. When the S-CSCF receives a request for that GRUU, it will be able to route the request to the registered SIP instance. The efficient use of network resources, which may include a radio interface or other low-bandwidth access, is essential in the IMS in order to provide the user with an acceptable experience in terms of latency. To achieve this goal, SIP messages can be compressed using the mechanism known

Context: Document [16](Title: Service layer) IP multimedia Subsystem Service Control Interface (ISC). The ISC interface uses the SIP signalling protocol. The network elements contained within the service layer are generically referred to as 'service platforms' however the 3GPP specification (3GPP TS 23.228 V8.7.0) defines several types of service platforms: The SIP Application Server (AS) performs the same function as a Telephony Application Server in a pre-IMS network, however it is specifically tailored to support the SIP signalling protocol for use in an IMS network. An OSA Service Capability Server acts as a secure gateway between the IMS network and an application which runs upon the

Context: Document [17](Title: SIP extensions for the IP Multimedia Subsystem) user agents (terminals) can describe themselves when they register so that others can search for them according to their caller preferences extension headers. For this purpose, they list their capabilities in the "Contact" header field of the REGISTER message. The aim of event notification is to obtain the status of a given resource (e.g. a user, one's voicemail service) and to receive updates of that status when it changes. Event notification is necessary in the IMS framework to inform about the "presence" of a user (i.e. "online" or "offline") to others that may be waiting to contact them, or to

Context: Document [18](Title: Session Initiation Protocol) corporate information system infrastructure by sharing Internet access for voice and data, and removing the cost for Basic Rate Interface (BRI) or Primary Rate Interface (PRI) telephone circuits. "SIP trunking" is a similar marketing term preferred for when the service is used to simplify a telecom infrastructure by sharing the carrier access circuit for voice, data, and Internet traffic while removing the need for Primary Rate Interface (PRI) circuits. SIP-enabled video surveillance cameras can initiate calls to alert the operator of events, such as motion of objects in a protected area. SIP is used in audio over IP for broadcasting

Context: Document [19](Title: Femtocell) up a connection between the femtocell and a femtocell convergence server (FCS). Voice calls are routed through the FCS which emulates an MSC. SIP is not required or used by the mobile device itself. In the SIP architecture, the femtocell connects to a core network of the mobile operator that is based on the SIP/IMS architecture. This is achieved by having the femtocells behave toward the SIP/IMS network like a SIP/IMS client by converting the circuit-switched 3G signaling to SIP/IMS signaling, and by transporting the voice traffic over RTP as defined in the IETF standards. Although much of the commercial

Context: Document [20](Title: Multimedia telephony) Multimedia telephony The 3GPP/NGN IP Multimedia Subsystem (IMS) multimedia telephony service (MMTel) is a global standard based on the IMS, offering converged, fixed and mobile real-time multimedia communication using the media capabilities such as voice, real-time video, text, file transfer and sharing of pictures, audio and video clips. With MMTel, users have the capability to add and drop media during a session. You can start with chat, add voice (for instance Mobile VoIP), add another caller, add video, share media and transfer files, and drop any of these without losing or having to end the session. MMTel is one of

Question: what does sip stand for in the ngn / ims context?

Answer: Session Initiation Protocol


Context: Document [1](Title: Session Initiation Protocol) permanent element of the IP Multimedia Subsystem (IMS) architecture for IP-based streaming multimedia services in cellular networks. In June 2002 the specification was revised in and various extensions and clarifications have been published since. SIP was designed to provide a signaling and call setup protocol for IP-based communications supporting the call processing functions and features present in the public switched telephone network (PSTN) with a vision of supporting new multimedia applications. It has been extended for video conferencing, streaming media distribution, instant messaging, presence information, file transfer, Internet fax and online games. SIP is distinguished by its proponents for having

Context: Document [2](Title: UMTS security) calls, video conferences, streaming and chat. SIP is specified by the Internet Engineering Task Force (IETF)27. IMS also uses the IETF Session Description Protocol (SDP)28 to specify the session parameters and to negotiate the codecs to be used. SIP runs on top of different IP transport protocols such as the User Datagram Protocol (UDP) and the Transmission Control Protocol (TCP). A 3G IMS subscriber has one IP multimedia private identity (IMPI) and at least one IP multimedia public identity (IMPU). To participate in multimedia sessions, an IMS subscriber must register at least one IMPU with the IMS. The private identity

Context: Document [3](Title: SIP extensions for the IP Multimedia Subsystem) extensions is not restricted to the IMS framework. The 3GPP has stated several general requirements stated for operation of the IMS. These include an efficient use of the radio interface by minimizing the exchange of signaling messages between the mobile terminal and the network, a minimum session setup time by performing tasks prior to session establishment instead of during session establishment, a minimum support required in the terminal, the support for roaming and non-roaming scenarios with terminal mobility management (supported by the access network, not SIP), and support for IPv6 addressing. Other requirements involve protocol extensions, such as SIP header

Context: Document [4](Title: SIP extensions for the IP Multimedia Subsystem) functionality. These extensions are based on Request for Comments (RFC) protocol recommendations by the IETF. The 3GPP, which is a collaboration between groups of telecommunications associations aimed at developing and maintaining the IMS, stated a series of requirements for SIP to be successfully used in the IMS. Some of them could be addressed by using existing capabilities and extensions in SIP while, in other cases, the 3GPP had to collaborate with the IETF to standardize new SIP extensions to meet the new requirements. In any case, the IETF evolves SIP in a generic basis, so that the use of its

Context: Document [5](Title: IP Multimedia Subsystem) To ease the integration with the Internet, IMS uses IETF protocols wherever possible, e.g., SIP (Session Initiation Protocol). According to the 3GPP, IMS is not intended to standardize applications, but rather to aid the access of multimedia and voice applications from wireless and wireline terminals, i.e., to create a form of fixed-mobile convergence (FMC). This is done by having a horizontal control layer that isolates the access network from the service layer. From a logical architecture perspective, services need not have their own control functions, as the control layer is a common horizontal layer. However, in implementation this does not

Context: Document [6](Title: SIP extensions for the IP Multimedia Subsystem) configured to relay messages across both networks according to these recommendations, user agents will need to implement extensions so that they can directly exchange media streams. These extensions are related to the Session Description Protocol offer/answer initial exchange, that will be used to gather the IPv4 and IPv6 addresses of both ends so that they can establish a direct communication. Apart from all the explained extensions to SIP that make it possible for the IMS to work successfully, it is also necessary that the IMS framework interworks and exchanges services with existing network infrastructures, mainly the Public switched telephone network

Context: Document [7](Title: SIP extensions for the IP Multimedia Subsystem) to negotiate and allocate the call resources before the called party is alerted. In the IMS framework, it is required that once the callee is alerted, the chances of a session failure are minimum. An important source of failure is the inability to reserve network resources to support the session, so these resources should be allocated before the phone rings. However, in the IMS, to reserve resources the network needs to know the callee's IP address, port and session parameters and therefore it is necessary that the initial offer/answer exchange to establish a session has started (INVITE request). In basic

Context: Document [8](Title: SIP extensions for the IP Multimedia Subsystem) resource reservation on its side. Subsequent UPDATE requests are sent to inform about the reservation progress, and they are answered by 2XX response codes. In a typical offer/answer exchange, one UPDATE will be sent by the calling party when its reservation is completed, then the called party will respond and eventually finish allocating the resources. It is then, when all the resources for the call are in place, when the caller is alerted. In the IMS framework it is fundamental to handle user identities for authentication, authorization and accounting purposes. The IMS is meant to provide multimedia services over IP

Context: Document [9](Title: SIP trunking) applications such as desktop sharing, web conferencing, and shared whiteboard. The architecture of SIP trunking provides a partitioning of the unified communications network into two different domains of expertise: The interconnection between the two domains must occur through a SIP trunk. The interconnection between the two domains, created by transport via the Internet Protocol (IP), involves setting specific rules and regulations as well as the ability to handle some services and protocols that fall under the name of SIP trunking. The ITSP is responsible to the applicable regulatory authority regarding all the following law obligations of the public domain: The

Context: Document [10](Title: Telecoms & Internet converged Services & Protocols for Advanced Networks) networking. In 2011, TISPAN published the specification of a functional architecture for Content Delivery Networks (CDN) and is now working on the specification of the protocols applicable to the reference points identified in this architecture (See ETSI TS 182 019) The ETSI website on Next Generation Networking states: ""Standards for fixed NGN were developed by the now closed ETSI technical committee TISPAN. The TC has adopted the 3GPP™ core IMS specifications using Internet (SIP) protocols to allow features such as Presence, IPTV, Messaging, and Conferencing to be delivered irrespective of the network in use. Maintenance of NGN standards are now

Context: Document [11](Title: SIP extensions for the IP Multimedia Subsystem) a format used to describe streaming media initialization parameters, carried in the body of SIP messages. The new SDP attributes are meant to describe the "current status" of the resource reservation, the "desired status" of the reservation to proceed with session establishment, and the "confirmation status", to indicate when the reservation status should be confirmed. In the IMS, the initial session parameter negotiation can be done by using the provisional responses and session description updating extensions, along with SDP in the body of the messages. The first offer, described by means of SDP, can be carried by the INVITE request

Context: Document [12](Title: IP Multimedia Subsystem) in a single network, for dimensioning, load balancing or organizational issues. The user can connect to IMS in various ways, most of which use the standard IP. IMS terminals (such as mobile phones, personal digital assistants (PDAs) and computers) can register directly on IMS, even when they are roaming in another network or country (the visited network). The only requirement is that they can use IP and run SIP user agents. Fixed access (e.g., Digital Subscriber Line (DSL), cable modems, Ethernet), mobile access (e.g. W-CDMA, CDMA2000, GSM, GPRS) and wireless access (e.g., WLAN, WiMAX) are all supported. Other phone systems

Context: Document [13](Title: SIP extensions for the IP Multimedia Subsystem) to the user agent. This extension is only applicable within administrative domains with trust relationships. It was particularly designed for specialized SIP networks like the IMS, and not for the general Internet. Source routing is the mechanism that allows the sender of a message to specify partially or completely the route the message traverses. In SIP, the "route" header field, filled by the sender, supports this functionality by listing a set of proxies the message will visit. In the IMS context, there are certain network entities (i.e. certain CSCFs) that must be traversed by requests from or to a user,

Context: Document [14](Title: Telecoms & Internet converged Services & Protocols for Advanced Networks) it ensures mobility of users, terminals and services as much as possible, even across administrative boundaries. A key subsystem is based on the architectures of 3rd Generation Partnership Project (3GPP) IP Multimedia Subsystem (IMS). TISPAN has been working with 3GPP to extend the IMS architecture with capabilities required in support of wire-line access. TISPAN NGN Release 2 was finalized early 2008, and added support for IPTV services and Business Communications over the IMS. Since early 2008, TISPAN has begun work on the third release of its NGN specifications with prime focus on IPTV enhancements, Content Delivery Networks (CDN) and home

Context: Document [15](Title: SIP extensions for the IP Multimedia Subsystem) SIP instance, and the registrar (i.e. S-CSCF) builds the GRUU, associates it to the registered identity and SIP instance and sends it back to the user agent in the response. When the S-CSCF receives a request for that GRUU, it will be able to route the request to the registered SIP instance. The efficient use of network resources, which may include a radio interface or other low-bandwidth access, is essential in the IMS in order to provide the user with an acceptable experience in terms of latency. To achieve this goal, SIP messages can be compressed using the mechanism known

Context: Document [16](Title: Service layer) IP multimedia Subsystem Service Control Interface (ISC). The ISC interface uses the SIP signalling protocol. The network elements contained within the service layer are generically referred to as 'service platforms' however the 3GPP specification (3GPP TS 23.228 V8.7.0) defines several types of service platforms: The SIP Application Server (AS) performs the same function as a Telephony Application Server in a pre-IMS network, however it is specifically tailored to support the SIP signalling protocol for use in an IMS network. An OSA Service Capability Server acts as a secure gateway between the IMS network and an application which runs upon the

Context: Document [17](Title: SIP extensions for the IP Multimedia Subsystem) user agents (terminals) can describe themselves when they register so that others can search for them according to their caller preferences extension headers. For this purpose, they list their capabilities in the "Contact" header field of the REGISTER message. The aim of event notification is to obtain the status of a given resource (e.g. a user, one's voicemail service) and to receive updates of that status when it changes. Event notification is necessary in the IMS framework to inform about the "presence" of a user (i.e. "online" or "offline") to others that may be waiting to contact them, or to

Context: Document [18](Title: Session Initiation Protocol) corporate information system infrastructure by sharing Internet access for voice and data, and removing the cost for Basic Rate Interface (BRI) or Primary Rate Interface (PRI) telephone circuits. "SIP trunking" is a similar marketing term preferred for when the service is used to simplify a telecom infrastructure by sharing the carrier access circuit for voice, data, and Internet traffic while removing the need for Primary Rate Interface (PRI) circuits. SIP-enabled video surveillance cameras can initiate calls to alert the operator of events, such as motion of objects in a protected area. SIP is used in audio over IP for broadcasting

Context: Document [19](Title: Femtocell) up a connection between the femtocell and a femtocell convergence server (FCS). Voice calls are routed through the FCS which emulates an MSC. SIP is not required or used by the mobile device itself. In the SIP architecture, the femtocell connects to a core network of the mobile operator that is based on the SIP/IMS architecture. This is achieved by having the femtocells behave toward the SIP/IMS network like a SIP/IMS client by converting the circuit-switched 3G signaling to SIP/IMS signaling, and by transporting the voice traffic over RTP as defined in the IETF standards. Although much of the commercial

Context: Document [20](Title: Multimedia telephony) Multimedia telephony The 3GPP/NGN IP Multimedia Subsystem (IMS) multimedia telephony service (MMTel) is a global standard based on the IMS, offering converged, fixed and mobile real-time multimedia communication using the media capabilities such as voice, real-time video, text, file transfer and sharing of pictures, audio and video clips. With MMTel, users have the capability to add and drop media during a session. You can start with chat, add voice (for instance Mobile VoIP), add another caller, add video, share media and transfer files, and drop any of these without losing or having to end the session. MMTel is one of

Question: what does sip stand for in the ngn / ims context?

Answer: Session Initiation Protocol