Luke's parents gave him 1 + 4 = <<1+4=5>>5 $50 bills.
These $50 bills amount to $50 x 5 = $<<50*5=250>>250.
His parents gave him 2 + 1 = <<2+1=3>>3 $20 bills.
These $20 bills amount to $20 x 3 = $<<20*3=60>>60.
His parents gave him 3 + 1 = <<3+1=4>>4 $10 bills.
These $10 bills amount to $10 x 4 = $<<10*4=40>>40.
Therefore, Luke's school fee is $250 + $60 + $40 = $<<250+60+40=350>>350.
#### 350