Amelia picks 45 - 18 = <<45-18=27>>27 oranges.
The total number of oranges that they pick is 45 + 27 = <<45+27=72>>72.
George picks 15 + 5 = <<15+5=20>>20 apples.
The total number of apples that they pick is 20 + 15 = <<20+15=35>>35.
So, they pick 72 + 35 = <<72+35=107>>107 fruits altogether.
#### 107