First find the number of pups in the first generation: 8 mice * 6 pups/mouse = <<8*6=48>>48 pups
Then add the number of adult mice to find the total number of mice: 48 pups + 8 mice = <<48+8=56>>56 mice
Then find the number of pups per mouse that survive from the second generation: 6 pups/mouse - 2 pups/mouse = <<6-2=4>>4 pups/mouse
Then multiply that number by the number of adult mice to find the number of pups in the second generation: 56 mice * 4 pups/mouse = <<56*4=224>>224 mice
Then add the number of adult mice to the number of second-generation pups to find the total number of mice: 224 mice + 56 mice = <<224+56=280>>280 mice
#### 280