As people are enjoying drinks in a bar, a man covered in blood—identified onscreen as "Hero" (Eric Dane)—enters through the door and warns them all of impending danger. No one heeds his warning, so he shows the bar patrons the head of a repulsive creature to make them take him seriously. He is soon pulled through a window and decapitated by one of the monsters. After the carnage, a woman—"Heroine" (Navi Rawat)—bursts through the door and reveals herself to be the recently deceased man's wife. After a brief sentimental moment between the wife and her late husband, the bar patrons begin boarding up the windows in the bar. Despite their efforts, a young monster bursts through an uncovered window and begins attacking. A monster outside bursts its hand through Vet (Anthony "Treach" Criss), Edgy Cat/Jason Mewes has his face torn off and is accidentally shot dead, and the little monster dismembers one of the women—"Harley Mom" (Diane Goldner)—who is initially assumed to have died from massive blood loss.
The monster disappears for some time, then is found attempting to sexually penetrate one of the deer heads nailed to the wall. A shotgun blast removes the deer head and monster. The monster drops into a freezer which is then sealed shut, trapping it inside. Following this, the remaining windows are boarded up and the bar patrons are given a moment of peace. Trying to call for help, they learn that the only phone in the bar has been hit by a stray shotgun blast and rendered useless. One of the women—"Tuffy" (Krista Allen)—suddenly realizes that her son Cody (Tyler Patrick Jones) is still upstairs and runs to get him. Once she finds her child the group rejoices until the boy is pulled through a window and eaten by one of the monsters, leaving only his sneaker behind. Tuffy is incapacitated by grief, while the monster vomits a stream of slime at one of the group—"Beer Guy" (Judah Friedlander). As the remaining people regroup downstairs, they realize that the slime has a decomposing effect and that Beer Guy is being slowly overcome by its effects.
The group kills the young monster in the freezer and hangs it outside. The monster's parents quickly eat the child, have sex and produce two offspring in a matter of seconds, all of whom begin to attack the pub with renewed fury. Meanwhile, one of the women—"Honey Pie" (Jenny Wade)—begins washing off the blood and has to take off her clothes, much to the amusement of the others. The patrons regroup and enact various attempts to escape or drive off the monsters, including using Harley Mom's body as bait while the Heroine and the "Coach" (Henry Rollins) attempt to escape. Upon discovering she's still alive, "Bossman" (Duane Whitaker) continues to sacrifice her to the creatures. The distraction fails, leading to the accidental death of the Heroine at the hands of another character, "Bozo" (Balthazar Getty). Driven by rage over the death of her child, Tuffy aggressively takes charge of the remaining survivors, which results in the audience seeing her nickname change from "Tuffy" to "Heroine 2". After "Coach" and "Bossman" are killed, "Honey Pie" successfully makes it to a truck, giving the other characters brief cause for hope (until they realize she is speeding off by herself).
A fight to the death between the last remaining humans and monsters ensues, resulting in the deaths of "Beer Guy" and supposedly the "Bartender" (Clu Gulager). Bozo, his brother Hot Wheels (Josh Zuckerman), and Tuffy (Heroine 2) survive, and drive off to retrieve the Heroine and Hero's daughter. One person—"Grandma" (Eileen Ryan)—seems to survive but is attacked by one of the remaining monsters.

Question: Who is Hero's wife?
Answer: Heroine.
Alternative answer: Heroine.