In the year 2274, the remnants of human civilization live in a sealed city contained beneath a cluster of geodesic domes, a utopia run by a computer that takes care of all aspects of their life, including reproduction. The citizens live a hedonistic life but, to maintain the city, everyone must undergo the ritual of "Carrousel" [sic] when they reach the age of 30. There, they are vaporized and ostensibly "renewed". To track this, each person is implanted at birth with a "life-clock" crystal in the palm of their hand that changes color as they get older and begins blinking as they approach their "Last Day". Most residents accept this promise of rebirth, but those who do not and attempt to flee the city are known as "Runners". An elite team of policemen known as "Sandmen", outfitted in predominantly black uniforms and serving in an agency of the city called "Deep Sleep", are assigned to pursue and terminate Runners as they try to escape.
Logan 5 and Francis 7 are both Sandmen. After terminating a Runner, to whose presence they were alerted during a Carrousel ritual, Logan finds an ankh among his possessions. Later that evening, he meets Jessica 6, a young woman also wearing an ankh pendant. Logan takes the ankh to the computer, which tells him that it is a symbol for a secret group whose members help the Runners find "Sanctuary", a mythical place where they will be safe to live out the rest of their lives; it points out that the Sandmen have lost one thousand and fifty-six (1056) Runners that way. The computer instructs Logan to find Sanctuary and destroy it, a mission he has to keep secret from the other Sandmen of Deep Sleep, which it code-names "Assignment 033-03". It then (by a procedure it calls a "retrogram") changes the color of his life-clock to flashing red, making him technically and suddenly four years older. In order to escape Carrousel, Logan is now forced to become a Runner. Logan meets Jessica and explains his situation. They meet with the underground group that leads them to the periphery of the city. Logan finds that the ankh symbol is actually a key that unlocks an exit from the city. They come out into a frozen cave, with Francis following closely behind. In the cave, they meet Box, a robot designed to capture food for the city from the outside. Logan discovers to his horror that Box also captures escaped Runners and freezes them. Before he (Box) can freeze Logan and Jessica, they escape, causing the cave to collapse on Box.
Once outside, Logan and Jessica notice that their life-clocks are no longer operational. They discover that the remains of human civilization have become a wilderness. They explore an old, seemingly abandoned city, which was once Washington D.C.. In the ruins of the United States Senate chamber, they discover an elderly man. His appearance is a shock to them since neither has seen anyone over the age of 30. The old man explains what he remembers of what happened to humanity outside of the city, and Logan realizes that Sanctuary is a myth and had been all along. However, Francis has followed them and he and Logan fight. Logan fatally wounds Francis and as he dies, he sees that Logan's life-clock is now clear and assumes that Logan has renewed. Logan and Jessica convince the old man to return to the city with them as proof that life exists outside the domed city. Leaving the man outside, the two enter and try to convince everyone that Carrousel is a lie and unnecessary. The two are captured by other Sandmen and taken to the computer. The computer interrogates Logan about Assignment 033-03 and asks if he completed his mission. But Logan insists, "There is no Sanctuary." What he had found was "old ruins, exposed", "an old man", and that the missing Runners were "all frozen". These answers, however, are not accepted by the computer, even after scanning Logan's mind, and the computer inexplicably overloads, causing the city's systems to fail violently and release the exterior seals. Logan, Jessica, and the other citizens flee the ruined city. Once outside, the citizens see the old man, the first human they have met who is older than 30, proving that they can indeed live their lives much longer.

Question: What does it mean when a human's hand begins to blink?
Answer: They are approaching their last day.
Alternative answer: They are approaching death