Ten years after tracking and taking down serial killer Jame Gumb, FBI Special Agent Clarice Starling is unjustly blamed for a botched drug raid. She is later contacted by Mason Verger, the only surviving victim of the serial killer Hannibal Lecter. A wealthy child molester, Verger was paralyzed and horribly disfigured by Lecter during a therapy session. He has been pursuing an elaborate scheme to capture, torture, and kill Lecter ever since. Using his wealth and political influence, Verger has Starling reassigned to Lecter's case, hoping her involvement will draw Lecter out.
After learning of Starling's public disgrace, Lecter sends her a taunting letter. Starling detects a strange fragrance from the letter. A perfume expert later identifies a skin cream whose ingredients are only available to a few shops in the world. She contacts the police departments of the cities where the shops are located, requesting surveillance tapes. In Florence, one of said cities, Chief Inspector Rinaldo Pazzi is investigating the disappearance of a library curator. Pazzi questions Lecter, who is masquerading as Dr. Fell, the assistant curator and caretaker.
Upon recognizing Dr. Fell in the surveillance tape, Pazzi accesses the ViCAP database of wanted fugitives. He then learns of Verger's US$3 million personal bounty on Lecter. Blinded by greed, Pazzi ignores Starling's warnings and attempts to capture Lecter alone. He recruits a pickpocket to obtain Lecter's fingerprint to show Verger as proof. The pickpocket, mortally wounded by Lecter, manages to get the print and provides it to Pazzi. Lecter baits Pazzi into an isolated room of the Palazzo Vecchio, ties him up, then disembowels and hangs him. He then heads back to the United States.
Verger bribes Justice Department official Paul Krendler to accuse Starling of withholding a note from Lecter, leading to her suspension. Lecter lures Starling to Union Station. Verger's men, having trailed Starling, capture and bring Lecter to Verger. Verger means to feed Lecter alive to a herd of wild boars bred specifically for this purpose. After her superiors refuse to act, Starling infiltrates Verger's estate. After neutralizing the two guards and freeing Lecter she is shot by a third guard that was in hiding. Lecter picks up an unconscious Starling just before the boars break through the doors, they are on their way out when Verger arrives. He orders his physician Cordell Doemling to shoot Lecter, but with Lecter's suggestion, Cordell shoves his hated boss into the pen. Lecter carries Starling and watches the boars eat Verger alive.
Lecter takes Starling to Krendler's secluded lake house and treats her wounds. When Krendler arrives for the Fourth of July, Lecter subdues and drugs him. Starling, disoriented by morphine and dressed in a black velvet evening gown, awakens to find Krendler seated at the table set for an elegant dinner. Weakened by the drugs, she looks on in horror as Lecter removes part of Krendler's prefrontal cortex, sautĂŠs it, and feeds it to him.
After the meal, Starling tries to attack Lecter but he overpowers her and the two share a kiss. Starling then handcuffs his wrist to hers. Hearing the police closing in, Lecter uses a meat cleaver to sever his own wrist in order to free their cuffed hands and escapes. Lecter is later seen on a flight with his own boxed lunch. As he prepares to eat his meal, including what is assumed to be part of a cooked brain, a young boy seated next to him asks to try some of his food. Initially reluctant, Lecter then lets the boy eat some of his lunch.

Question: Why is Starling's reputation ruined?
Answer: Because of a faulty drug bust
Alternative answer: She was blamed for a drug raid that went wrong.