bowang0911/MedQuAD huggingface dataset:
Key Points
                    - Chronic myelogenous leukemia is a disease in which the bone marrow makes too many white blood cells.    - Leukemia may affect red blood cells, white blood cells, and platelets.    - Signs and symptoms of chronic myelogenous leukemia include fever, night sweats, and tiredness.     - Most people with CML have a gene mutation (change) called the Philadelphia chromosome.    - Tests that examine the blood and bone marrow are used to detect (find) and diagnose chronic myelogenous leukemia.    - Certain factors affect prognosis (chance of recovery) and treatment options.
                
                
                    Chronic myelogenous leukemia is a disease in which the bone marrow makes too many white blood cells.
                    Chronic myelogenous leukemia (also called CML or chronic granulocytic leukemia) is a slowly progressing blood and bone marrow disease that usually occurs during or after middle age, and rarely occurs in children.
                
                
                    Leukemia may affect red blood cells, white blood cells, and platelets.
                    Normally, the bone marrow makes blood stem cells (immature cells) that become mature blood cells over time. A blood stem cell may become a myeloid stem cell or a lymphoid stem cell. A lymphoid stem cell becomes a white blood cell.    A myeloid stem cell becomes one of three types of mature blood cells:         -  Red blood cells that carry oxygen and other substances to all tissues of the body.    -  Platelets that form blood clots to stop bleeding.    -  Granulocytes (white blood cells) that fight infection and disease.         In CML, too many blood stem cells become a type of white blood cell called granulocytes. These granulocytes are abnormal and do not become healthy white blood cells. They are also called leukemia cells. The leukemia cells can build up in the blood and bone marrow so there is less room for healthy white blood cells, red blood cells, and platelets. When this happens, infection, anemia, or easy bleeding may occur.   This summary is about chronic myelogenous leukemia. See the following PDQ summaries for more information about leukemia:          -  Adult Acute Lymphoblastic Leukemia Treatment     -  Childhood Acute Lymphoblastic Leukemia Treatment     -  Adult Acute Myeloid Leukemia Treatment     -  Childhood Acute Myeloid Leukemia/Other Myeloid Malignancies Treatment     -  Chronic Lymphocytic Leukemia Treatment     -  Hairy Cell Leukemia Treatment
Signs and symptoms of chronic myelogenous leukemia include fever, night sweats, and tiredness. These and other signs and symptoms may be caused by CML or by other conditions. Check with your doctor if you have any of the following:         - Feeling very tired.    - Weight loss for no known reason.    - Night sweats.    -  Fever.    - Pain or a feeling of fullness below the ribs on the left side.        Sometimes CML does not cause any symptoms at all.
Most people with CML have a gene mutation (change) called the Philadelphia chromosome. Every cell in the body contains DNA (genetic material) that determines how the cell looks and acts. DNA is contained inside chromosomes. In CML, part of the DNA from one chromosome moves to another chromosome. This change is called the  Philadelphia chromosome. It results in the bone marrow making an enzyme, called tyrosine kinase, that causes too many stem cells to become white blood cells (granulocytes or blasts).   The Philadelphia chromosome is not passed from parent to child.
Tests that examine the blood and bone marrow are used to detect (find) and diagnose chronic myelogenous leukemia.. The following tests and procedures may be used:         -   Physical exam and history : An exam of the body to check general signs of health, including checking for signs of disease such as an enlarged spleen. A history of the patients health habits and past illnesses and treatments will also be taken.    -   Complete blood count (CBC) with differential : A procedure in which a sample of blood is drawn and checked for the following:                -  The number of red blood cells and platelets.      - The number and type of white blood cells.      - The amount of hemoglobin (the protein that carries oxygen) in the red blood cells.      - The portion of the blood sample made up of red blood cells.              -   Blood chemistry studies : A procedure in which a blood sample is checked to measure the amounts of certain substances released into the blood by organs and tissues in the body. An unusual (higher or lower than normal) amount of a substance can be a sign of disease.     -   Bone marrow aspiration and biopsy : The removal of bone marrow, blood, and a small piece of bone by inserting a needle into the hipbone or breastbone. A pathologist views the bone marrow, blood, and bone under a microscope to look for abnormal cells. One of the following tests may be done on the samples of blood or bone marrow tissue that are removed:                -  Cytogenetic analysis: A test in which cells in a sample of blood or bone marrow are viewed under a microscope to look for certain changes in the chromosomes, such as the Philadelphia chromosome.      -  FISH (fluorescence in situ hybridization): A laboratory technique used to look at genes or chromosomes in cells and tissues. Pieces of DNA that contain a fluorescent dye are made in the laboratory and added to cells or tissues on a glass slide. When these pieces of DNA bind to specific genes or areas of chromosomes on the slide, they light up when viewed under a microscope with a special light.       -  Reverse transcriptionpolymerase chain reaction (RTPCR): A laboratory test in which cells in a sample of tissue are studied using chemicals to look for certain changes in the structure or function of genes.
Key Points
                    - After chronic myelogenous leukemia has been diagnosed, tests are done to find out if the cancer has spread.    - Chronic myelogenous leukemia has 3 phases.         - Chronic phase     - Accelerated phase     - Blastic phase
                
                
                    After chronic myelogenous leukemia has been diagnosed, tests are done to find out if the cancer has spread.
                    Staging is the process used to find out how far the cancer has spread. There is no standard staging system for chronic myelogenous leukemia (CML). Instead, the disease is classified by phase: chronic phase, accelerated phase, or blastic phase. It is important to know the phase in order to plan treatment. The information from tests and procedures done to detect (find) and diagnose chronic myelogenous leukemia is also used to plan treatment.
                
                
                    Chronic myelogenous leukemia has 3 phases.
                    As the amount of blast cells increases in the blood and bone marrow, there is less room for healthy white blood cells, red blood cells, and platelets. This may result in infections, anemia, and easy bleeding, as well as bone pain and pain or a feeling of fullness below the ribs on the left side. The number of blast cells in the blood and bone marrow and the severity of signs or symptoms determine the phase of the disease.     Chronic phase    In chronic phase CML, fewer than 10% of the cells in the blood and bone marrow are blast cells.       Accelerated phase    In accelerated phase CML, 10% to 19% of the cells in the blood and bone marrow are blast cells.       Blastic phase    In blastic phase CML, 20% or more of the cells in the blood or bone marrow are blast cells. When tiredness, fever, and an enlarged spleen occur during the blastic phase, it is called blast crisis.
Key Points
                    - Primary myelofibrosis is a disease in which abnormal blood cells and fibers build up inside the bone marrow.    - Symptoms of primary myelofibrosis include pain below the ribs on the left side and feeling very tired.    - Certain factors affect prognosis (chance of recovery) and treatment options for primary myelofibrosis.
                
                
                    Primary myelofibrosis is a disease in which abnormal blood cells and fibers build up inside the bone marrow.
                    The bone marrow is made of tissues that make blood cells (red blood cells, white blood cells, and platelets) and a web of fibers that support the blood-forming tissues. In primary myelofibrosis (also called chronic idiopathic myelofibrosis), large numbers of blood stem cells become blood cells that do not mature properly (blasts). The web of fibers inside the bone marrow also becomes very thick (like scar tissue) and slows the blood-forming tissues ability to make blood cells. This causes the blood-forming tissues to make fewer and fewer blood cells. In order to make up for the low number of blood cells made in the bone marrow, the liver and spleen begin to make the blood cells.
Symptoms of primary myelofibrosis include pain below the ribs on the left side and feeling very tired. Primary myelofibrosis often does not cause early signs or symptoms. It may be found during a routine blood test. Signs and symptoms may be caused by primary myelofibrosis or by other conditions. Check with your doctor if you have any of the following:         - Feeling pain or fullness below the ribs on the left side.    - Feeling full sooner than normal when eating.    - Feeling very tired.    - Shortness of breath.    - Easy bruising or bleeding.    -  Petechiae (flat, red, pinpoint spots under the skin that are caused by bleeding).    -  Fever.    - Night sweats.    - Weight loss.
Certain factors affect prognosis (chance of recovery) and treatment options for primary myelofibrosis. Prognosis (chance of recovery) depends on the following:         - The age of the patient.    - The number of abnormal red blood cells and white blood cells.    - The number of blasts in the blood.    - Whether there are certain changes in the chromosomes.    - Whether the patient has signs such as fever, night sweats, or weight loss.
Treatment of primary myelofibrosis in patients without signs or symptoms is usually watchful waiting.    Patients with primary myelofibrosis may have signs or symptoms of anemia. Anemia is usually treated with transfusion of red blood cells to relieve symptoms and improve quality of life. In addition, anemia may be treated with:             -  Erythropoietic growth factors.     -  Prednisone.     -  Danazol.     -  Thalidomide, lenalidomide, or pomalidomide, with or without prednisone.            Treatment of primary myelofibrosis in patients with other signs or symptoms may include the following:            -  Targeted therapy with ruxolitinib.     -  Chemotherapy.     -  Donor stem cell transplant.     - Thalidomide, lenalidomide, or pomalidomide.     -  Splenectomy.     -  Radiation therapy to the spleen, lymph nodes, or other areas outside the bone marrow where blood cells are forming.     -  Biologic therapy using interferon alfa or erythropoietic growth factors.     - A clinical trial of other targeted therapy drugs.            Check the list of NCI-supported cancer clinical trials that are now accepting patients with primary myelofibrosis. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your doctor about clinical trials that may be right for you. General information about clinical trials is available from the NCI website.
Age can affect the risk of plasma cell neoplasms. Anything that increases your risk of getting a disease is called a risk factor. Having a risk factor does not mean that you will get cancer; not having risk factors doesn't mean that you will not get cancer. Talk with your doctor if you think you may be at risk.    Plasma cell neoplasms are most common in people who are middle aged or older. For multiple myeloma and plasmacytoma, other risk factors include the following:          - Being black.    - Being male.    - Having a personal history of MGUS or plasmacytoma.    - Being exposed to radiation or certain chemicals.
Certain factors affect prognosis (chance of recovery) and treatment options. The prognosis (chance of recovery) depends on the following:         - The type of plasma cell neoplasm.    - The stage of the disease.    - Whether a certain immunoglobulin (antibody) is present.    - Whether there are certain genetic changes.    - Whether the kidney is damaged.    - Whether the cancer responds to initial treatment or recurs (comes back).        Treatment options depend on the following:         - The type of plasma cell neoplasm.    - The age and general health of the patient.    - Whether there are signs, symptoms, or health problems, such as kidney failure or infection, related to the disease.    - Whether the cancer responds to initial treatment or recurs (comes back).
Key Points
                    - A pituitary tumor is a growth of abnormal cells in the tissues of the pituitary gland.    - The pituitary gland hormones control many other glands in the body.    - Having certain genetic conditions increases the risk of developing a pituitary tumor.    - Signs of a pituitary tumor include problems with vision and certain physical changes.    - Imaging studies and tests that examine the blood and urine are used to detect (find) and diagnose a pituitary tumor.    - Certain factors affect prognosis (chance of recovery) and treatment options.
                
                
                    A pituitary tumor is a growth of abnormal cells in the tissues of the pituitary gland.
                    Pituitary tumors form in the pituitary gland, a pea-sized organ in the center of the brain, just above the back of the nose. The pituitary gland is sometimes called the "master endocrine gland" because it makes hormones that affect the way many parts of the body work. It also controls hormones made by many other glands in the body.      Pituitary tumors are divided into three groups:         -  Benign pituitary adenomas: Tumors that are not cancer. These tumors grow very slowly and do not spread from the pituitary gland to other parts of the body.     - Invasive pituitary adenomas: Benign tumors that may spread to bones of the skull or the sinus cavity below the pituitary gland.    - Pituitary carcinomas: Tumors that are malignant (cancer). These pituitary tumors spread into other areas of the central nervous system (brain and spinal cord) or outside of the central nervous system. Very few pituitary tumors are malignant.        Pituitary tumors may be either non-functioning or functioning.          - Non-functioning pituitary tumors do not make extra amounts of hormones.    - Functioning pituitary tumors make more than the normal amount of one or more hormones. Most pituitary tumors are functioning tumors. The extra hormones made by pituitary tumors may cause certain signs or symptoms of disease.
                
                
                    The pituitary gland hormones control many other glands in the body.
                    Hormones made by the pituitary gland include:         -  Prolactin: A hormone that causes a womans breasts to make milk during and after pregnancy.     -  Adrenocorticotropic hormone (ACTH): A hormone that causes the adrenal glands to make a hormone called cortisol. Cortisol helps control the use of sugar, protein, and fats in the body and helps the body deal with stress.    -  Growth hormone: A hormone that helps control body growth and the use of sugar and fat in the body. Growth hormone is also called somatotropin.    -  Thyroid-stimulating hormone: A hormone that causes the thyroid gland to make other hormones that control growth, body temperature, and heart rate. Thyroid-stimulating hormone is also called thyrotropin.     -  Luteinizing hormone (LH) and follicle-stimulating hormone (FSH): Hormones that control the menstrual cycle in women and the making of sperm in men.
Having certain genetic conditions increases the risk of developing a pituitary tumor.Anything that increases your risk of getting a disease is called a risk factor. Having a risk factor does not mean that you will get cancer; not having risk factors doesnt mean that you will not get cancer. Talk with your doctor if you think you may be at risk. Risk factors for pituitary tumors include having the following hereditary diseases:         -  Multiple endocrine neoplasia type 1 (MEN1) syndrome.    -  Carney complex.    - Isolated familial acromegaly.
Signs of a pituitary tumor include problems with vision and certain physical changes. Signs and symptoms can be caused by the growth of the tumor and/or by hormones the tumor makes or by other conditions. Some tumors may not cause signs or symptoms. Check with your doctor if you have any of these problems.     Signs and symptoms of a non-functioning pituitary tumor    Sometimes, a pituitary tumor may press on or damage parts of the pituitary gland, causing it to stop making one or more hormones. Too little of a certain hormone will affect the work of the gland or organ that the hormone controls. The following signs and symptoms may occur:         - Headache.    - Some loss of vision.    - Loss of body hair.    - In women, less frequent or no menstrual periods or no milk from the breasts.     - In men, loss of facial hair, growth of breast tissue, and impotence.    - In women and men, lower sex drive.    -  In children, slowed growth and sexual development.        Most of the tumors that make LH and FSH do not make enough extra hormone to cause signs and symptoms. These tumors are considered to be non-functioning tumors.    Signs and symptoms of a functioning pituitary tumor    When a functioning pituitary tumor makes extra hormones, the signs and symptoms will depend on the type of hormone being made.    Too much prolactin may cause:          - Headache.    - Some loss of vision.    - Less frequent or no menstrual periods or menstrual periods with a very light flow.     - Trouble becoming pregnant or an inability to become pregnant.    - Impotence in men.    - Lower sex drive.    - Flow of breast milk in a woman who is not pregnant or breast-feeding.         Too much ACTH may cause:          - Headache.    - Some loss of vision.    - Weight gain in the face, neck, and trunk of the body, and thin arms and legs.     - A lump of fat on the back of the neck.    - Thin skin that may have purple or pink stretch marks on the chest or abdomen.    - Easy bruising.    - Growth of fine hair on the face, upper back, or arms.    - Bones that break easily.    -  Anxiety, irritability, and depression.         Too much growth hormone may cause:          - Headache.    - Some loss of vision.    - In adults, acromegaly (growth of the bones in the face, hands, and feet). In children, the whole body may grow much taller and larger than normal.    - Tingling or numbness in the hands and fingers.    - Snoring or pauses in breathing during sleep.    -  Joint pain.    - Sweating more than usual.    - Dysmorphophobia (extreme dislike of or concern about one or more parts of the body).         Too much thyroid-stimulating hormone may cause:          - Irregular heartbeat.    - Shakiness.    - Weight loss.     - Trouble sleeping.    - Frequent bowel movements.    - Sweating.         Other general signs and symptoms of pituitary tumors:          -  Nausea and vomiting.    -  Confusion.    - Dizziness.    -  Seizures.    - Runny or "drippy" nose (cerebrospinal fluid that surrounds the brain and spinal cord leaks into the nose).
Certain factors affect prognosis (chance of recovery) and treatment options. The prognosis (chance of recovery) depends on the type of tumor and whether the tumor has spread into other areas of the central nervous system (brain and spinal cord) or outside of the central nervous system to other parts of the body.   Treatment options depend on the following:         - The type and size of the tumor.    - Whether the tumor is making hormones.    - Whether the tumor is causing problems with vision or other signs or symptoms.    - Whether the tumor has spread into the brain around the pituitary gland or to other parts of the body.    - Whether the tumor has just been diagnosed or has recurred (come back).
Key Points
                    - Once a pituitary tumor has been diagnosed, tests are done to find out if it has spread within the central nervous system (brain and spinal cord) or to other parts of the body.     - Pituitary tumors are described in several ways.
                
                
                    Once a pituitary tumor has been diagnosed, tests are done to find out if it has spread within the central nervous system (brain and spinal cord) or to other parts of the body.
                    The extent or spread of cancer is usually described as stages. There is no standard staging system for pituitary tumors. Once a pituitary tumor is found, tests are done to find out if the tumor has spread into the brain or to other parts of the body. The following test may be used:          -   MRI (magnetic resonance imaging): A procedure that uses a magnet, radio waves, and a computer to make a series of detailed pictures of areas inside the body. This procedure is also called nuclear magnetic resonance imaging (NMRI).
                
                
                    Pituitary tumors are described in several ways.
                    Pituitary tumors are described by their size and grade, whether or not they make extra hormones, and whether the tumor has spread to other parts of the body.   The following sizes are used:         - Microadenoma: The tumor is smaller than 1 centimeter.    - Macroadenoma: The tumor is 1 centimeter or larger.        Most pituitary adenomas are microadenomas.    The grade of a pituitary tumor is based on how far it has grown into the surrounding area of the brain, including the sella (the bone at the base of the skull, where the pituitary gland sits).